Science.gov

Sample records for das formas indirectas

  1. Massa do gás e das estrelas em aglomerados: eficiência da formação estelar

    NASA Astrophysics Data System (ADS)

    Laganá, T. F.; Lima Neto, G. B.

    2003-08-01

    Os aglomerados de galáxias apresentam um interesse especial para a cosmologia observacional. Eles são as maiores estruturas ligadas pela gravitação no Universo e relaxadas na região central. A comparação entre a massa do gás intra-aglomerado (responsável por ~25% da massa total, inferida a partir de observações em raios-X), a massa contida nas estrelas (i.e., nas galáxias) e a massa total (incluindo a matéria escura não bariônica), nos dá informações importantes sobre os processos de formação e evolução de aglomerados. Por exemplo, a razão entre a massa do gás e a massa total é uma medida da fração de bárions no Universo (razão entre a matéria bariônica e matéria escura) e, utilizando a densidade de bárions predita pela nucleosíntese primordial, podemos deduzir a densidade de matéria escura no Universo (cf. White et al. 1993). O objetivo deste trabalho é obter as razões entre as massas do gás, estelar (contida nas galáxias), e a total (massa dinâmica). As massas do gás e total são obtidas a partir das análises fotométrica e espectroscópica em raios-X enquanto que a massa estelar é obtida pela análise fotométrica das galáxias. Esta análise foi aplicada ao aglomerado Abell 496 observado pelo satélite XMM-Newton. A massa contida nas galáxias foi estimada a partir da função de luminosidade obtida por Durret et al. (2002). Para determinar as massas dinâmica e do gás nos precisamos determinar os perfis radiais de densidade e temperatura. Nós apresentaremos aqui estes resultados e suas implicações na eficiência da formação estelar em Abell 496.

  2. Rotação do jato em DG tau próximo à região de sua formação: análise comparativa das velocidades radiais simuladas e observadas

    NASA Astrophysics Data System (ADS)

    Cerqueira, A. H.; de Gouveia dal Pino, E. M.

    2003-08-01

    Os modelos magneto-centrífugos utilizados para explicar a formação dos jatos Herbig-Haro assumem a presença de um disco de acresção em rotação kepleriana na base de lançamento do jato. Neste cenário, o jato transmite a informação da rotação do disco para regiões distantes da fonte central, além da superfície de Alfvén, na região de colimação inicial do jato. Recentemente, Bacciotti et al. (2002, ApJ, 537, L49) obtiveram pela primeira vez uma evidência observacional de rotação em um jato HH, o jato em DG Tau, em regiões próximas da fonte central, compatível (qualitativa e quantitativamente) com o esperado a partir dos modelos magneto-centrífugos para a produção e colimação inicial de jatos HH. No presente trabalho, apresentamos mapas de velocidade radial, obtidos através de simulações numéricas tri-dimensionais SPH, para um jato com características semelhantes ao jato em DG Tau, objetivando uma comparação com os mapas de velocidade radiais obtidos por Bacciotti et al.. Nossos resultados, embora preliminares, indicam que a inclusão de efeitos como a precessão, evidenciada em DG Tau (Dougados et al. 2000, A&A, 357, L61) devem ser levadas em consideração na análise da presença de rotação não só em DG Tau mas em qualquer sistema, com o uso das velocidades radias observadas. A ausência de um grau elevado de simetria axial (quebrada, por exemplo, pela precessão do eixo do jato; ou pela presença de uma superfície interna de trabalho, ou seja, um bow shock interno), implica também em uma maior complexidade nos mapas, com conseqüências relevantes para suas interpretações.

  3. High School Student's Alternative Conceptions About the Phenomenon of the Formation of the Moon Phases. (Spanish Title: Concepciones Alternativas de Alumnos de Educación Media Sobre el Fenómeno de Formación de las Fases de La Luna.) Concepções Alternativas de Alunos do Ensino Médio Sobre o Fenômeno de Formação das Fases da Lua

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Langhi, Rodolfo; Fernandes Scalvi, Rosa Maria

    2008-07-01

    Forty students, at ages between 14 and 18 years old, from three schools in Bauru city, were questioned about their alternative conceptions concerning the phenomenon of formation of the Moon Phases. It was observed that some of the pupils confound the phenomenon of the formation of the Moon Phases with the phenomenon of the formation of the lunar eclipses, others are unaware of the reason of the phenomenon, they present incoherent alternative conceptions of the reality or incomplete conceptions. The results found here are aimed at the teachers of Elementary Education and can be used as a subsidy for future development of new pedagogical methods. Cuarenta estudiantes, con edad entre 14 y 18 años, pertenecientes a tres escuelas de la ciudad de Bauru, fueron cuestionados sobre sus concepciones alternativas acerca del fenómeno de la formación de las fases de la Luna. Fue observado que algunos alumnos confunden el fenómeno de formación de las fases de la Luna con el fenómeno de formación de los eclipses lunares, otros desconocen el motivo delfenómeno, presentan concepciones alternativas incoherentes con la realidad o bien presentan concepciones incompletas. Los resultados aquí encontrados son destinados a los profesores de la Enseñanza Básica y podrán ser usados como ayuda para el futuro desarrollo de nuevos métodos pedagógicos. Quarenta estudantes, com idades entre 14 e 18 anos, pertencentes a três escolas da cidade de Bauru, foram questionados sobre suas concepções alternativas acerca do fenômeno de formação das fases da Lua. Foi observado que alguns dos alunos confundem o fenômeno da formação das fases da Lua com o fenômeno da formação dos eclipses lunares, outros desconhecem o motivo do fenômeno, apresentam concepções alternativas incoerentes com a realidade ou então concepções incompletas. Os resultados aqui encontrados são destinados aos professores do Ensino Básico e poderão ser usados como subsídio parafuturo desenvolvimento de

  4. DAS performance analysis

    SciTech Connect

    Bates, G.; Bodine, S.; Carroll, T.; Keller, M.

    1984-02-01

    This report begins with an overview of the Data Acquisition System (DAS), which supports several of PPPL's experimental devices. Performance measurements which were taken on DAS and the tools used to make them are then described.

  5. DAS User Manual

    NASA Astrophysics Data System (ADS)

    Østensen, Roy

    2008-10-01

    The HELAS Database for AsteroSeismology (DAS) is one of the deliverables of the Work Package NA5: Asteroseismology of the European Coordination Action in Helio- and Asteroseismology (HELAS). The DAS aims to provide easy access to publicly available asteroseismological timeseries data, both photometric and spectroscopic. In particular, the DAS and the HELAS software package FAMIAS are ideally suited to train Master and PhD students in asteroseismic data analysis and to build longterm datasets. The number of stars in the system is still limited and reflects the willingness of data owners to provide their data after publication. Work continues to populate the database with contributions from the community, and at present the number of stars in the database is 82

  6. Ambiente e formação estelar em galáxias

    NASA Astrophysics Data System (ADS)

    Mateus, A., Jr.; Sodré, L., Jr.

    2003-08-01

    Estudamos o ambiente de galáxias com formação estelar inicialmente a partir de uma amostra limitada em volume proveniente do 2dF Galaxy Redshift Survey. Discriminamos as galáxias com formação estelar com base em distintas classes espectrais, utilizando para esta classificação as larguras equivalentes das linhas [OII]l3727 e Hd. O ambiente é caracterizado pela densidade espacial local de galáxias. Mostramos que a fração de galáxias com formação estelar é bastante reduzida em ambientes densos, enquanto a de galáxias passivas aumenta nestas regiões. Por outro lado, quando analisamos a fração de galáxias que apresentam um surto recente de formação estelar, notamos que ela independe do ambiente, sendo que em regiões mais densas alguns destes objetos apresentam distorções em sua morfologia. Estes resultados são confrontados com a análise da dependência ambiental da taxa de formação estelar, estimada pela emissão em Ha, de uma amostra extraída do Sloan Digital Sky Survey. Um declínio gradual da formação estelar também é observado nesta análise, sugerindo que as interações por efeitos de maré sejam responsáveis pela redução da formação estelar em ambientes densos através da remoção do reservatório de gás das galáxias. No entanto, estas interações também podem induzir surtos de formação estelar nas galáxias, além de peculiaridades morfológicas observadas nos objetos que habitam regiões mais densas.

  7. Das DNA-Puzzle

    NASA Astrophysics Data System (ADS)

    Kirchner, Stefan

    Im Jahre 1953 wurde von James Watson und Francis Crick erstmalig der strukturelle Aufbau der sogenannten DNA (Desoxyribonukleinsäure) beschrieben, welche das Erbgut jedes Lebewesens enthält. Der wesentliche Teil des Erbguts wird dabei durch eine sehr lange Folge der vier Basen Adenin (A), Cytosin (C), Guanin (G) und Thymin (T) codiert. Seit einigen Jahren ist es möglich, die Folge der vier Basen zu einer gegebenen DNA zu bestimmen. Biologen bezeichnen diesen Vorgang als Sequenzierung.

  8. 19 CFR 141.85 - Pro forma invoice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Pro forma invoice. 141.85 Section 141.85 Customs... (CONTINUED) ENTRY OF MERCHANDISE Invoices § 141.85 Pro forma invoice. A pro forma invoice submitted in accordance with any provision of this chapter shall be in substantially the following form: Pro Forma Invoice...

  9. Das Zwillingsparadoxon: Gedankenexperimente

    NASA Astrophysics Data System (ADS)

    Genz, Henning

    2002-09-01

    Das vermeintliche Zwillingsparadoxon ist ein Gedankenexperiment mit einem Zwillingspaar: Ein Zwilling reist mit hoher Geschwindigkeit von der Erde weg und kehrt nach einiger Zeit zurück, sein Partner bleibt auf der Erde. Dabei altert der Reisende langsamer als der Ruhende - warum nicht umgekehrt? Ein Vergleich von Uhren, die sich mit konstanter Geschwindigkeit bewegen, zeigt: Der Effekt hängt nur von Geschwindigkeiten und nicht von Beschleunigungen ab. Er beruht also allein auf der Speziellen Relativitätstheorie. Tauschen die Zwillinge in regelmäßigen Abständen Lichtsignale aus, können sie ihr asymmetrisches Altern sogar in Zeitschritten mitprotokollieren.

  10. Das Allgemeine Statistische Archiv

    NASA Astrophysics Data System (ADS)

    Rinne, Horst

    Das Allgemeine Statistische Archiv1, nachfolgend kurz Archiv genannt, ist die älteste, ausschließlich der Statistik gewidmete deutschsprachige wissenschaftliche Fachzeitschrift. Sie ist gut zwanzig Jahre älter als die Deutsche Statistische Gesellschaft, zu deren Publikationsorgan sie mit der Gründung der Gesellschaft im Jahre 1911 wurde. Zeitschrift und Gesellschaft blicken auf eine sehr wechselvolle, aber erfolgreiche gemeinsame Geschichte zurück. Die wissenschaftliche Arbeit der Gesellschaft ist im Archiv und seinen Sonderheften für nachfolgende Generationen dokumentiert.

  11. The utility of Pro Forma Income Statements.

    PubMed

    Reiboldt, Max; Reiboldt, John

    2002-01-01

    Recent headlines surrounding the financial demise of the nation's seventh largest company, Enron, and its subsequent entanglements with its accounting and consulting firm, Arthur Andersen, have placed a cloud of suspicion upon many reasonable business practices that otherwise are considered standard procedure. The proforma income statement is one of those practices. An oft-used tool in financial management, pro formas play a useful role for projecting financial performance based on predictable forecasts or assumptions. Regardless of the current scrutiny, there is still a valid use for accurately prepared statements.

  12. Connecting the Dots in DAS

    ERIC Educational Resources Information Center

    Ford, Tracy

    2012-01-01

    Many institutions implement a distributed antenna system (DAS) as part of a holistic approach to providing better wireless coverage and capacity on campus. A DAS provides wireless service within a particular area or structure via a network of separate antenna nodes that are connected to a common source through fiber or coaxial cable. Because DAS…

  13. Connecting the Dots in DAS

    ERIC Educational Resources Information Center

    Ford, Tracy

    2012-01-01

    Many institutions implement a distributed antenna system (DAS) as part of a holistic approach to providing better wireless coverage and capacity on campus. A DAS provides wireless service within a particular area or structure via a network of separate antenna nodes that are connected to a common source through fiber or coaxial cable. Because DAS…

  14. MyDas, an extensible Java DAS server.

    PubMed

    Salazar, Gustavo A; García, Leyla J; Jones, Philip; Jimenez, Rafael C; Quinn, Antony F; Jenkinson, Andrew M; Mulder, Nicola; Martin, Maria; Hunter, Sarah; Hermjakob, Henning

    2012-01-01

    A large number of diverse, complex, and distributed data resources are currently available in the Bioinformatics domain. The pace of discovery and the diversity of information means that centralised reference databases like UniProt and Ensembl cannot integrate all potentially relevant information sources. From a user perspective however, centralised access to all relevant information concerning a specific query is essential. The Distributed Annotation System (DAS) defines a communication protocol to exchange annotations on genomic and protein sequences; this standardisation enables clients to retrieve data from a myriad of sources, thus offering centralised access to end-users.We introduce MyDas, a web server that facilitates the publishing of biological annotations according to the DAS specification. It deals with the common functionality requirements of making data available, while also providing an extension mechanism in order to implement the specifics of data store interaction. MyDas allows the user to define where the required information is located along with its structure, and is then responsible for the communication protocol details.

  15. Expansion and improvement of the FORMA system for response and load analysis. Volume 2B: Listings, sparse FORMA subroutines

    NASA Technical Reports Server (NTRS)

    Wohlen, R. L.

    1976-01-01

    A listing of the source deck of each sparse FORMA subroutine is given to remove the 'black-box' aura of the subroutines so that the analyst may better understand the detailed operations of each subroutine. The format of a sparse matrix on a utility tape is also presented. The FORTRAN 4 programming language is used in all sparse FORMA subroutines.

  16. Expansion and improvement of the FORMA system for response and load analysis. Volume 2C: Listings, finite element FORMA subroutines

    NASA Technical Reports Server (NTRS)

    Wohlen, R. L.

    1976-01-01

    A listing of the source deck of each finite element FORMA subroutine is given to remove the 'black-box' aura of the subroutines so that the analyst may better understand the detailed operations of each subroutine. The FORTRAN 4 programming language is used in all finite element FORMA subroutines.

  17. A eficiência de formação estelar em Musca

    NASA Astrophysics Data System (ADS)

    Hickel, G. R.; Vilas-Boas, J. W. S.; Roberto, A. J.., Jr.; Khan, R. P.

    2003-08-01

    Apresentamos os resultados de um survey no infravermelho próximo (bandas J e H), executado no Laboratório Nacional de Astrofísica, na direção da nuvem escura em forma de filamento de Musca (observamos ao longo de todo o filamento, além de todas as fontes pontuais IRAS e/ou fontes ROSAT brilhantes a uma distância de 2o da nuvem). Nosso objetivo é determinar a eficiência de formação estelar para esta nuvem escura (massa de estrelas formadas/massa da nuvem), procurando por objetos estelares jovens de pequena massa no seu interior e/ou evoluídos o suficiente para estarem afastados do local de nascimento, mas ainda mostrando características de objetos pré-seqüência principal como emissão de raios-X e excesso de emissão no infravermelho próximo. Este survey não estabeleceu nenhum viés na seleção de fontes pontuais IRAS ou fontes ROSAT, uma vez que a imensa maioria das fontes pontuais IRAS nesta região têm qualidade de fluxo ruim. Os candidatos a objetos estelares jovens foram selecionados pelo excesso no índice de cor (J-H), descontados os efeitos da extinção interestelar na linha de visada, determinada através da emissão estendida no infravermelho distante (IRAS). Estimativas de massa foram feitas para estes candidatos, através da relação massa-luminosidade, para calcular a eficiência de formação estelar de Musca.

  18. Comparison of the DAS28-CRP and DAS28-ESR in patients with rheumatoid arthritis.

    PubMed

    Sengul, Ilker; Akcay-Yalbuzdag, Seniz; Ince, Bugra; Goksel-Karatepe, Altinay; Kaya, Taciser

    2015-07-01

    To compare the Disease Activity Score with 28 joint (DAS28) using erythrocyte sedimentation rate (ESR) (DAS28-ESR) and DAS28 using C-reactive protein (CRP) (DAS28-CRP) with thresholds validated for DAS28-ESR in Turkish patients with rheumatoid arthritis. The DAS28 data of 112 patients with rheumatoid arthritis followed in a local outpatient clinic were used. First, the correlation between DAS28-CRP and DAS28-ESR and the correlation between their unique components ([0.36 × In (CRP + 1) + 0.96] and [0.70 × In (ESR)]) were analyzed. Second, a Bland-Altman plot was constructed for the evaluation of the level of agreement between DAS28-CRP and DAS28-ESR. Lastly, the agreement between these two methods was analyzed by κ coefficient. Although there was a strong correlation between DAS28-CRP and DAS28-ESR, the correlation between their unique components was fair. Although more than 95% of the point data fall between the upper and lower bounds of the limit of agreement, the percentage error (46%) was higher than the acceptable proportion of 30%. The κ coefficient of agreement between DAS28- ESR and DAS28-CRP with validated thresholds for DAS28-ESR was 0.42, which was close to the lower boundary for moderate agreement. The results of this study demonstrated that there is discordance between DAS28-ESR and DAS28-CRP with the validated thresholds for DAS28-ESR. Using the DAS28-CRP with threshold values validated for DAS28-ESR may lead to errors in the determination of disease activity and therefore may lead to errors in the management of patients with rheumatoid arthritis. © 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  19. Effector profiles distinguish formae speciales of Fusarium oxysporum

    USDA-ARS?s Scientific Manuscript database

    Formae speciales (ff. spp.) of the fungus Fusarium oxysporum are often polyphyletic in their origin, meaning that strains that infect a particular plant species are not necessarily more closely related to each other than to strains that cause disease in another host. Nevertheless, since strains of t...

  20. Affordance, Learning Opportunities, and the Lesson Plan Pro Forma

    ERIC Educational Resources Information Center

    Anderson, Jason

    2015-01-01

    This article argues that the most commonly used lesson plan pro formas in language teacher education are inappropriately premised on an outcomes-based approach to teaching, one that is in conflict with what we know about how languages are learnt and how experienced teachers teach. It proposes an alternative, affordance-based approach to lesson…

  1. 19 CFR 122.74 - Incomplete (pro forma) manifest.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Incomplete (pro forma) manifest. 122.74 Section 122.74 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT...; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  2. 17 CFR 210.8-05 - Pro forma financial information.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975 Article 8 Financial... consummated during the most recent fiscal year or subsequent interim period, pro forma statements of income... (2) If consummation of the transaction has occurred or is probable after the date of the most recent...

  3. Effector profiles distinguish formae speciales of Fusarium oxysporum.

    PubMed

    van Dam, Peter; Fokkens, Like; Schmidt, Sarah M; Linmans, Jasper H J; Kistler, H Corby; Ma, Li-Jun; Rep, Martijn

    2016-11-01

    Formae speciales (ff.spp.) of the fungus Fusarium oxysporum are often polyphyletic within the species complex, making it impossible to identify them on the basis of conserved genes. However, sequences that determine host-specific pathogenicity may be expected to be similar between strains within the same forma specialis. Whole genome sequencing was performed on strains from five different ff.spp. (cucumerinum, niveum, melonis, radicis-cucumerinum and lycopersici). In each genome, genes for putative effectors were identified based on small size, secretion signal, and vicinity to a "miniature impala" transposable element. The candidate effector genes of all genomes were collected and the presence/absence patterns in each individual genome were clustered. Members of the same forma specialis turned out to group together, with cucurbit-infecting strains forming a supercluster separate from other ff.spp. Moreover, strains from different clonal lineages within the same forma specialis harbour identical effector gene sequences, supporting horizontal transfer of genetic material. These data offer new insight into the genetic basis of host specificity in the F. oxysporum species complex and show that (putative) effectors can be used to predict host specificity in F. oxysporum. © 2016 Society for Applied Microbiology and John Wiley & Sons Ltd.

  4. Affordance, Learning Opportunities, and the Lesson Plan Pro Forma

    ERIC Educational Resources Information Center

    Anderson, Jason

    2015-01-01

    This article argues that the most commonly used lesson plan pro formas in language teacher education are inappropriately premised on an outcomes-based approach to teaching, one that is in conflict with what we know about how languages are learnt and how experienced teachers teach. It proposes an alternative, affordance-based approach to lesson…

  5. Expansion and improvement of the FORMA system for response and load analysis. Volume 2A: Listings, dense FORMA subroutines

    NASA Technical Reports Server (NTRS)

    Wohlen, R. L.

    1976-01-01

    A listing of the source deck of each dense FORMA subroutine is given to remove the 'black-box' aura of the subroutines so that the analyst may better understand the detail operations of each subroutine. The FORTRAN 4 programming language is used throughout.

  6. Data Acquisition System(DAS) Sustaining Engineering

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This paper presents general information describing the Data Acquisition System contract, a summary of objectives, tasks performed and completed. The hardware deliverables which are comprised of: 1) Two ground DAS units; 2) Two flight DAS units; 3) Logistic spares; and 4) Shipping containers are described. Also included are the data requirements and scope of the contract.

  7. DAS28-CRP and DAS28-ESR cut-offs for high disease activity in rheumatoid arthritis are not interchangeable

    PubMed Central

    Fleischmann, Roy M; van der Heijde, Désirée; Gardiner, Philip V; Szumski, Annette; Marshall, Lisa; Bananis, Eustratios

    2017-01-01

    Background In most patients with rheumatoid arthritis (RA), Disease Activity Score 28-joint count C reactive protein (DAS28-CRP) is lower than DAS28 erythrocyte sedimentation rate (DAS28-ESR), suggesting that use of the DAS28-ESR cut-off to assess high disease activity (HDA) with DAS28-CRP may underestimate the number of patients with HDA. We determined the DAS28-CRP value corresponding to the validated DAS28-ESR cut-off for HDA. Methods Baseline data were pooled from 2 clinical studies evaluating etanercept (ETN) plus methotrexate (MTX) or MTX in early RA; DAS28-CRP and DAS28-ESR were obtained, allowing the determination of the DAS28-CRP HDA value best corresponding to the DAS28-ESR cut-off of >5.1. Results At baseline, as expected, fewer patients had HDA by DAS28-CRP than DAS28-ESR; DAS28-CRP>5.1 and DAS28-ESR>5.1 had only modest agreement (κ coefficients 0.45–0.54). Mean DAS28-CRP and DAS28-ESR were 5.7 and 6.2, respectively, in the ETN+MTX group (n=571), and 6.0 and 6.5 in the MTX group (n=262). A DAS28-CRP cut-off of 4.6 corresponded to a DAS28-ESR cut-off of 5.1. Conclusions We have shown that a DAS28-CRP of 4.6 corresponds to 5.1 for DAS28-ESR. Since this is substantially lower than the DAS28-ESR cut-off of 5.1, using 5.1 as the cut-off for DAS28-CRP underestimates disease activity in RA. Trial registration number NCT00195494; NCT00913458. PMID:28255449

  8. Captura de satélites durante a formação de Júpiter

    NASA Astrophysics Data System (ADS)

    Winter, O. C.; Vieira Neto, E.; Yokoyama, T.

    2003-08-01

    O planeta Jupiter apresenta um grande número de satélites irregulares. As características das órbitas destes objetos indicam que os mesmos não teriam se formado ao redor do planeta que se encontram. As teorias existentes são de que estes objetos teriam se formado em uma região distante do planeta e sua evolução dinâmica os teria levado a uma captura gravitacional pelo planeta. Tendo em vista que o processo de captura gravitacional sem efeitos dissipativos não produz uma captura permanente, estudamos o processo de captura durante o estágio de formação do planeta. Realizamos simulações numéricas para os casos de satélites prógrados e retrógrados que inicialmente se encontram ao redor de Jupiter com sua massa atual e então, evoluimos a integração voltando no tempo de modo que o planeta sofra uma redução em sua massa (de 100% para 10% de sua massa atual) e verificamos o instante em que o satélites escapa do planeta (quando sua energia do problema de dois corpos se torna positiva). Assim, analisando o problema inverso no tempo, obtivemos em qual estágio de formação de Jupiter aquele hipotético satélite teria sido capturado. Os resultados mostram que os satélites retrógrados são capturados assim que entram na região delimitada pela esfera de Hill do planeta, enquanto que os satélites prógrados só são capturados quando entram numa região bem mais próxima ao planeta, uma fração da esfera de Hill.

  9. Dasty3, a WEB framework for DAS

    PubMed Central

    Villaveces, Jose M.; Jimenez, Rafael C.; Garcia, Leyla J.; Salazar, Gustavo A.; Gel, Bernat; Mulder, Nicola; Martin, Maria; Garcia, Alexander; Hermjakob, Henning

    2011-01-01

    Motivation: Dasty3 is a highly interactive and extensible Web-based framework. It provides a rich Application Programming Interface upon which it is possible to develop specialized clients capable of retrieving information from DAS sources as well as from data providers not using the DAS protocol. Dasty3 provides significant improvements on previous Web-based frameworks and is implemented using the 1.6 DAS specification. Availability: Dasty3 is an open-source tool freely available at http://www.ebi.ac.uk/dasty/ under the terms of the GNU General public license. Source and documentation can be found at http://code.google.com/p/dasty/. Contact: hhe@ebi.ac.uk PMID:21798964

  10. GHRSST-14 DAS-TAG Report

    NASA Technical Reports Server (NTRS)

    Armstrong, Edward; Piolle, Jean Francois

    2013-01-01

    The DAS-TAG provides the informatics and data management expertise in emerging information technologies for the GHRSST community. It provides expertise in data and metadata formats and standards, fosters improvements for GHRSST data curation, experiments with new data processing paradigms, and evaluates services and tools for data usage. It provides a forum for producer and distributor data management issues and coordination.

  11. Physik gestern und heute Das Eiskalorimeter

    NASA Astrophysics Data System (ADS)

    Heering, P.

    2003-07-01

    Kalorimetrische Messungen gehören heute zum experimentellen Standardrepertoire im Bereich der Thermodynamik und der physikalischen Chemie. Das erste Gerät für derartige Messungen entwickelten Ende des 18. Jahrhunderts die französischen Wissenschaftler Antoine Laurent Lavoisier und Pierre Simon de Laplace.

  12. GHRSST-14 DAS-TAG Report

    NASA Technical Reports Server (NTRS)

    Armstrong, Edward; Piolle, Jean Francois

    2013-01-01

    The DAS-TAG provides the informatics and data management expertise in emerging information technologies for the GHRSST community. It provides expertise in data and metadata formats and standards, fosters improvements for GHRSST data curation, experiments with new data processing paradigms, and evaluates services and tools for data usage. It provides a forum for producer and distributor data management issues and coordination.

  13. The Science Teachers and Their way of Thinking about Astronomy. (Spanish Title: Los Profesores de Ciencias y Sus Formas de Pensar la Astronomía.) Os Professores de Ciências e Suas Formas de Pensar a Astronomia

    NASA Astrophysics Data System (ADS)

    Leite, Cristina; Hosoume, Yassuko

    2007-12-01

    ómicos y la estructura espacial del montaje del Universo son características fundamentales. Muchos indican Sol y estrellas como cosas distintas: el Sol es un objeto caliente y las estrellas son frías. Esos resultados nos preocupan y ciertamente señalan una urgencia de programas de formación continuada para profesores en el contenido de astronomía, pues los PCN's (Parámetros Curriculares Nacionales) recomiendan con énfasis la enseñanza de este contenido. O modo de pensar dos professores de Ciências do ensino fundamental sobre os elementos da Astronomia é o objeto de pesquisa presente neste artigo, cuja metodologia consiste em entrevistas semiestruturadas, filmadas em vídeo e centradas numa perspectiva tridimensional dos elementos astronômicos, possibilitando um mapeamento das concepções das formas e das dimensões da Terra, do Sol, da Lua, dos planetas e das estrelas, bem como da concepção de céu e de Universo como um todo. Os resultados indicam um Universo contendo: Sol, estrelas, planetas e Lua, onde o Sistema Solar é parte do todo. Algumas vezes o Universo é concebido como o próprio Sistema Solar. Os objetos estão no céu ou no Universo o qual, para muitos, se restringe ao espaço que está acima da Terra. A forma plana dos objetos astronômicos e a estrutura espacial da montagem do Universo são características marcantes. Muitos indicam Sol e estrelas como coisas diferentes: Sol é um objeto quente e as estrelas são frias. Esses resultados nos preocupam e certamente sinalizam uma urgência de programas de formação continuada para professores no conteúdo de astronomia, uma vez que os PCN's indicam fortemente o ensino desse conteúdo.

  14. Control of Oxidative Sulfur Metabolism of Chlorobium limicola forma thiosulfatophilum

    PubMed Central

    Cork, Douglas; Mathers, Jeremy; Maka, Andrea; Srnak, Anna

    1985-01-01

    A metered blend of anaerobic-grade N2, CO2, and H2S gases was introduced into an illuminated, 800-ml liquid volume, continuously stirred tank reactor. The system, described as an anaerobic gas-to-liquid phase fed-batch reactor, was used to investigate the effects of H2S flow rate and light energy on the accumulation of oxidized sulfur compounds formed by the photoautotroph Chlorobium limicola forma thiosulfatophilum during growth. Elemental sulfur was formed and accumulated in stoichiometric quantities when light energy and H2S molar flow rate levels were optimally adjusted in the presence of nonlimiting CO2. Deviation from the optimal H2S and light energy levels resulted in either oxidation of sulfur or complete inhibition of sulfide oxidation. Based on these observations, a model of sulfide and sulfur oxidases electrochemically coupled to the photosynthetic reaction center of Chlorobium spp. is presented. The dynamic deregulation of oxidative pathways may be a mechanism for supplying the photosynthetic reaction center with a continuous source of electrons during periods of varying light and substrate availability, as in pond ecosystems where Chlorobium spp. are found. Possible applications for a sulfide gas removal process are discussed. PMID:16346713

  15. Moisture Forecast Bias Correction in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D.

    1999-01-01

    Data assimilation methods rely on numerous assumptions about the errors involved in measuring and forecasting atmospheric fields. One of the more disturbing of these is that short-term model forecasts are assumed to be unbiased. In case of atmospheric moisture, for example, observational evidence shows that the systematic component of errors in forecasts and analyses is often of the same order of magnitude as the random component. we have implemented a sequential algorithm for estimating forecast moisture bias from rawinsonde data in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The algorithm is designed to remove the systematic component of analysis errors and can be easily incorporated in an existing statistical data assimilation system. We will present results of initial experiments that show a significant reduction of bias in the GEOS DAS moisture analyses.

  16. [Effect of the school health promotion strategy "Forma Joven"].

    PubMed

    Lima-Serrano, Marta; Lima-Rodríguez, Joaquín Salvador

    2017-02-22

    To evaluate the impact of the Youth Form Strategy (EFJ, Estrategia Forma Joven) on the attitudes and behaviours of students in the fourth year of compulsory secondary school in Seville, Spain. A longitudinal observational design was used with two groups; one received the EFJ (EFJ group) and other did not (non-EFJ group). In the initial evaluation, 402 participants were randomly selected and, in the follow-up at 6 months, 322 participants were evaluated (161 per group). Validated data collection tools were used, and 2×2 tables, odds ratio (OR) and general ANOVA for 2×2 mixed factorial design (p<0.05) were calculated. Favourable effects of the EFJ were found: in the area of sexuality, the percentage of participants who had sexual intercourse in the final assessment was lower in the EFJ group (14.9% vs 23.4%; OR=0.57), as were counter-effects: start of tobacco use was higher in the EFJ group (19.5% vs 9.1%; OR=2.43). However, these differences were not statistically significant. The similarities in the school health promotion programme in centres with and without EFJ may have influenced the lack of conclusive results. Individual and/or group counselling at schools, a distinguishing feature of the EFJ, could have delayed sexual intercourse in the EFJ group. Based on the studies on school health promotion activities, good practices that could help to improve the effectiveness of the EFJ are recommended. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. 17 CFR 240.15c1-9 - Use of pro forma balance sheets.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Use of pro forma balance sheets. 240.15c1-9 Section 240.15c1-9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... pro forma balance sheets. The term manipulative, deceptive, or other fraudulent device or contrivance...

  18. 17 CFR 240.15c1-9 - Use of pro forma balance sheets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Use of pro forma balance sheets. 240.15c1-9 Section 240.15c1-9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... pro forma balance sheets. The term manipulative, deceptive, or other fraudulent device or contrivance...

  19. 17 CFR 240.15c1-9 - Use of pro forma balance sheets.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Use of pro forma balance sheets. 240.15c1-9 Section 240.15c1-9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... pro forma balance sheets. The term manipulative, deceptive, or other fraudulent device or contrivance...

  20. 17 CFR 240.15c1-9 - Use of pro forma balance sheets.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Use of pro forma balance sheets. 240.15c1-9 Section 240.15c1-9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... pro forma balance sheets. The term manipulative, deceptive, or other fraudulent device or contrivance...

  1. 17 CFR 240.15c1-9 - Use of pro forma balance sheets.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Use of pro forma balance sheets. 240.15c1-9 Section 240.15c1-9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... pro forma balance sheets. The term manipulative, deceptive, or other fraudulent device or contrivance...

  2. PoroTomo: DAS Vibroseis Data

    DOE Data Explorer

    Kurt Feigl

    2016-03-25

    The submitted data correspond to the monitored vibrations caused by a vibroseis seismically exciting the ground in the vertical direction and captured by the DAS horizontal and vertical arrays during the PoroTomo Experiment. The data also include a file with the acceleration record at the Vibroseis. Vibroseis Sweep Details: Sweep on location T84 Stage 4 (Mode P 60 s long record ) Time: 2016-03-25 14:01:15 (UTC) Location: 39.80476089N, -119.0027625W Elevation: 1272.0M (on ground surface at the site) Sweep length: 20 seconds Frequencies: 5 Hz to 20 Hz

  3. Das CARNOTsche Paradigma und seine erkenntnistheoretischen Implikationen

    NASA Astrophysics Data System (ADS)

    Schöpf, Hans-Georg

    Der vorliegende historisch-kritische Essay führt die Eigentümlichkeiten der klassischen phänomenologischen Thermodynamik auf das von CARNOT geschaffene Paradigma zurück und greift einige damit zusammenhängende Fragen auf.Translated AbstractCARNOT's Paradigm and its Epistemological ImplicationsThe present historic-critical essay traces the pecularities of classical phenomenological thermodynamics back to the paradigm, created by CARNOT, and takes up some questions to which this paradigm gives rise.

  4. Histochemistry of Centroorhynchus falconis (Das, 1950).

    PubMed

    Rengaraju, V; Das, E N

    1976-01-01

    With a view to augment the understanding of the animal mucosubstances in general and Acanthocephalan mucosubstances in particular, Acanthocephalan worms of (Centrorhynchus falconis, Das, 1950) were investigated histochemically by employing recent techniques. Variations in the intensity of histochemical reactions in different tissues revealed a heterogenous distribution of mucosubstances. The cuticle contained a mixture of periodate reactive neutral mucosubstances and sulfomucins, whereas the subcuticle contained only glycogen. Retractor muscles contained glycogen together with some acidic mucosubstances which exhibited alcianophilia only at high pH. Cement glands elaborated a mixture of glycogen and galactogen. Histochemical methods revealed two types of acanthors: Some contained only glycogen, whereas others contained glycogen and galactogen.

  5. PoroTomo Project - Subatask 6.2: Deploy and Operate DAS and DTS arrays - DAS Earthquake Data

    DOE Data Explorer

    Kurt Feigl

    2016-03-21

    The submitted data correspond to the vibration caused by a 3.4 M earthquake and captured by the DAS horizontal and vertical arrays during the PoroTomo Experiment. Earthquake information : M 4.3 - 23km ESE of Hawthorne, Nevada Time: 2016-03-21 07:37:10 (UTC) Location: 38.479°N 118.366°W Depth: 9.9 km Files for horizontal DAS array (each file is 30 s long and contain 8700 channels): PoroTomo_iDAS16043_160321073721.sgy PoroTomo_iDAS16043_160321073751.sgy Files for vertical DAS Array (each file is 30 s long and contain 380 channels): PoroTomo_iDAS025_160321073717.sgy PoroTomo_iDAS025_160321073747.sgy

  6. Análise da cinemática interna das regiões HII gigantes e das galáxias HII

    NASA Astrophysics Data System (ADS)

    Plana, H.; Telles, E.; Maíz-Apellániz, J.

    2003-08-01

    Neste trabalho nós mostramos os primeiros resultados de um estudo sobre a cinemática das Regiões HII Gigantes (GHIIRs) em galáxias próximas. Essas regiões HII têm um diâmetro médio entre 100 pc e 1000 pc e uma taxa de formação estelar de 106 M¤ / ano sendo equivalente à observada em galáxias de tipo tardio correspondendo a uma taxa de formação estelar por unidade de volume uma ordem de magnitude maior que a observada em regiões HII normais. Usando espectros de fenda longas em várias posições, nós construímos mapas de velocidades, de dispersão e de intensidade para várias linhas de emissão como Ha, Hb, [NII]6584 Å, [OIII]5007 Å e o doublet de [SII], para cinco regiões gigantes: NGC 2403 II e IV, NGC 595, NGC 5461, NGC 5471, NGC 5455. O estudo da cinemática (mapas de velocidades e da dispersão) mostrou, por exemplo, a presença de cascas em expansão em NGC 595 ou perfis de emissão com várias componentes em NGC 5461. Os perfis de emissão também mostram velocidades supersônicas. Os resultados são discutidos em comparação com os de estudos anteriores realizados.

  7. "Das Konkrete ist das Abstrakte, an das man sich schließlich gewöhnt hat." (Laurent Schwartz) Über den Ablauf des mathematischen Verstehens

    NASA Astrophysics Data System (ADS)

    Lowsky, Martin

    Die im Titel genannte Aussage findet sich in den Lebenserinnerungen von Laurent Schwartz (1915-2002), einem der fruchtbarsten Mathematiker, Mitglied der Gruppe Bourbaki. Im Original lautet die Aussage: "un objet concret est un objet abstrait auquel on a fini par s'habituer." Schwartz erläutert sie am Beispiel des Integrals über {e^{-1/2{x^2}}} , das den Wert Wurzel aus 2π hat und in dem sich also die Zahlen e und π verknüpfen. Was Schwartz aber vor allem ausdrücken will, ist dies: Das mathematische Verständnisd geht langsam vor sich und es bedarf der Anstrengung. "Es ist eine Frage der Zeit und der Energie", sagt Schwartz, und gerade dies mache es so schwer, die höhere Mathematik unter das Volk zu bringen. Das Lernen und Lehren von Mathematik laufe eben mühevoll und langsam ab.

  8. Pedagogical Basis of DAS Formalism in Engineering Education

    ERIC Educational Resources Information Center

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-01-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other…

  9. Evidence of Motor Programming Deficits in Children Diagnosed with DAS.

    ERIC Educational Resources Information Center

    Nijland, Lian; Maassen, Ben; van der Meulen, Sjoeke

    2003-01-01

    Five children with developmental apraxia of speech (DAS), 5 controls (ages 5-6), and 6 adults produced utterances in a normal condition and in a bite-block condition in which the mandible was in a fixed position. In children with DAS, the bite-block had large effects on coarticulatory patterns and vowel quality. (Contains references.) (Author/CR)

  10. Pedagogical Basis of DAS Formalism in Engineering Education

    ERIC Educational Resources Information Center

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-01-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other…

  11. On ambiente de binárias de pequena massa em formação: o caso do glóbulo cometário CG30 e IRAS08076-3556

    NASA Astrophysics Data System (ADS)

    Hickel, G. R.; Vilas-Boas, J. W. S.

    2003-08-01

    Neste trabalho, combinamos observações de polarização linear no óptico (banda R), dados no infravermelho distante (IRAS) e observações de transições moleculares em radiofreqüências (CO e espécies isotópicas, HCN e HCO+) para analisar o glóbulo cometário (GC) CG30 (na região da IRAS Vela Shell), que apresenta objetos Herbig-Haro e ejeções de matéria, além de uma fonte pontual IRAS em seu interior. Os objetivos deste estudo são: determinar a eficiência de formação estelar nos glóbulos cometários, através da relação entre a massa total do GC e da massa das estrelas em formação; determinar como o campo magnético influencia na formação de estrelas no interior destes objetos; e analisar as modificações que ejeções de matéria de estrelas em formação causam no gás e no campo magnético dos GCs. Combinando nossos dados com trabalhos já publicados, mostramos que CG30 tem uma eficiência de formação estelar em torno de 3%; que o campo magnético é importante na manutenção da estrutura global do GC e demonstra sinais de torção e compressão; e que a ejeção bipolar de matéria das estrelas do par formam uma ejeção quadripolar, a qual influencia na densidade e temperatura do gás e no grau de polarização dos grãos de poeira associados ao gás do GC.

  12. Código para imageamento indireto de estrelas em sistemas binarios: simulação de variações elipsoidais e do perfil das linhas

    NASA Astrophysics Data System (ADS)

    Souza, T. R.; Baptista, R.

    2003-08-01

    As estrelas secundárias em variáveis cataclí smicas (VCs) e binárias-x de baixa massa (BXBMs) são cruciais para o entendimento da origem, evolução e comportamento destas binárias interagentes. Elas são estrelas magneticamente ativas submetidas a condições ambientais extremas [e.g., estão muito próximas de uma fonte quente e irradiante; têm rotação extremamente rápida e forma distorcida; estão perdendo massa a taxas de 10-8-10-10 M¤/ano] que contribuem para que suas propriedades sejam distintas das de estrelas de mesma massa na seqüência principal. Por outro lado, o padrão de irradiação na face da secundária fornece informação sobre a geometria das estruturas de acréscimo em torno da estrela primária. Assim, a obtenção de imagens da superfície destas estrelas é de grande interesse astrofísico. A Tomografia Roche usa as variações no perfil das linhas de emissão/absorção da estrela secundária em função da fase orbital para mapear a distribuição de brilho em sua superfície. Neste trabalho apresentamos os resultados iniciais do desenvolvimento de um programa para o mapeamento da distribuição de brilho na superfí cie das estrelas secundárias em VCs e BXBMs com técnicas de astro-tomografia. Presentemente temos em operação um código que simula as variações no perfil das linhas em conseqüência de efeito Doppler resultante da combinação de rotação e translação de uma estrela em forma de lobo de Roche em torno do centro de massa da binária, em função da distribuição de brilho na superfície desta estrela. O código igualmente produz a curva de luz resultante das variações de aspecto da estrela em função da fase orbital (variações elipsoidais).

  13. Twenty‐eight‐joint counts invalidate the DAS28 remission definition owing to the omission of the lower extremity joints: a comparison with the original DAS remission

    PubMed Central

    Landewé, R; van der Heijde, D; van der Linden, S; Boers, M

    2006-01-01

    Objective To compare 28 joint disease activity score (DAS28) remission with comprehensive joint count DAS remission in rheumatoid arthritis. Methods 620 actually measured paired observations of DAS28 and DAS were analysed in 155 patients. Discordant observations (either DAS or DAS28 below remission cut off level: 1.6 for DAS and 2.6 for DAS28) and concordant observations (both DAS and DAS28 below their remission cut off level) were analysed separately. Results 91 of 620 paired DAS observations (15%) were discordant; 87 (in 53 patients) comprised observations in which the DAS28 remission criterion, but not the DAS remission criterion, was met. The reverse was found in only four observations, which were therefore omitted. With the original DAS as standard, DAS28 sensitivity was 95% and specificity 84%. Probability plots showed a swollen joint count >0 in 75% of discordant pairs v 48% of concordant pairs. The same was found for total joint count (TJC >0 in 90% v 40%; median TJC, 0 v 6) and patient global assessment, but not for ESR. Individual joint analysis showed that 51% of discordant v 18% of concordant observations (p<0.0005) had involvement of lower extremity joints that are not included in the DAS28. Conclusions DAS remission is more conservative than DAS28 remission. Activity (tenderness and swelling) in joints not included in the reduced joint counts (ankles, feet) mainly account for the discrepancy between the two assessments. DAS28 remission at a cut off level of 2.6 has insufficient construct validity and should be used with caution in clinical practice and clinical trials. PMID:16219709

  14. Authoring Multiple "Formas de ser": Three Bilingual Latino/a Fifth Graders Navigating School

    ERIC Educational Resources Information Center

    Cuero, Kimberley K.

    2009-01-01

    Drawing from sociocultural and anthropological perspectives, I present 3 case examples of bilingual, Mexican-origin students enrolled in a transitional bilingual educational program in an urban elementary school. By using the theoretical constructs of figured worlds, authoring, and "formas de ser" (ways of being), I examine how student identities…

  15. El Sistema de Formas en Colores for Teaching Grammar in Spanish

    ERIC Educational Resources Information Center

    Nailon, James

    2010-01-01

    Sistema de formas en colores (SFC) is a symbols-based system for teaching Spanish grammatical structures and concepts within a communicative context in the elementary school. The (ACTFL) Standards for Foreign Language Learning: Preparing for the 21st Century states that, "While grammar and vocabulary are essential tools for communication, it is…

  16. El Sistema de Formas en Colores for Teaching Grammar in Spanish

    ERIC Educational Resources Information Center

    Nailon, James

    2010-01-01

    Sistema de formas en colores (SFC) is a symbols-based system for teaching Spanish grammatical structures and concepts within a communicative context in the elementary school. The (ACTFL) Standards for Foreign Language Learning: Preparing for the 21st Century states that, "While grammar and vocabulary are essential tools for communication, it is…

  17. 47 CFR 1.224 - Motion to proceed in forma pauperis.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... is not seeking personal financial gain. (b) In the case of a licensee, the motion to proceed in forma.... Personal financial information may be submitted to the presiding officer in confidence. (c)(1) In the case... dedicated financial resources to sustain his participation which are reasonable in light of his...

  18. 47 CFR 1.224 - Motion to proceed in forma pauperis.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... is not seeking personal financial gain. (b) In the case of a licensee, the motion to proceed in forma.... Personal financial information may be submitted to the presiding officer in confidence. (c)(1) In the case... dedicated financial resources to sustain his participation which are reasonable in light of his...

  19. 47 CFR 1.224 - Motion to proceed in forma pauperis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... is not seeking personal financial gain. (b) In the case of a licensee, the motion to proceed in forma.... Personal financial information may be submitted to the presiding officer in confidence. (c)(1) In the case... dedicated financial resources to sustain his participation which are reasonable in light of his...

  20. 47 CFR 1.224 - Motion to proceed in forma pauperis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Motion to proceed in forma pauperis. 1.224 Section 1.224 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Hearing... importance, which cannot, or apparently will not, be introduced by other parties to the proceeding, and who...

  1. DAS: A Data Management System for Instrument Tests and Operations

    NASA Astrophysics Data System (ADS)

    Frailis, M.; Sartor, S.; Zacchei, A.; Lodi, M.; Cirami, R.; Pasian, F.; Trifoglio, M.; Bulgarelli, A.; Gianotti, F.; Franceschi, E.; Nicastro, L.; Conforti, V.; Zoli, A.; Smart, R.; Morbidelli, R.; Dadina, M.

    2014-05-01

    The Data Access System (DAS) is a and data management software system, providing a reusable solution for the storage of data acquired both from telescopes and auxiliary data sources during the instrument development phases and operations. It is part of the Customizable Instrument WorkStation system (CIWS-FW), a framework for the storage, processing and quick-look at the data acquired from scientific instruments. The DAS provides a data access layer mainly targeted to software applications: quick-look displays, pre-processing pipelines and scientific workflows. It is logically organized in three main components: an intuitive and compact Data Definition Language (DAS DDL) in XML format, aimed for user-defined data types; an Application Programming Interface (DAS API), automatically adding classes and methods supporting the DDL data types, and providing an object-oriented query language; a data management component, which maps the metadata of the DDL data types in a relational Data Base Management System (DBMS), and stores the data in a shared (network) file system. With the DAS DDL, developers define the data model for a particular project, specifying for each data type the metadata attributes, the data format and layout (if applicable), and named references to related or aggregated data types. Together with the DDL user-defined data types, the DAS API acts as the only interface to store, query and retrieve the metadata and data in the DAS system, providing both an abstract interface and a data model specific one in C, C++ and Python. The mapping of metadata in the back-end database is automatic and supports several relational DBMSs, including MySQL, Oracle and PostgreSQL.

  2. Pedagogical basis of DAS formalism in engineering education

    NASA Astrophysics Data System (ADS)

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-03-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other engineering fields. The motivation for this new curriculum structure originates from the urge to solve the problems that engineering education has faced during the past decades, e.g. student recruitment problems and dissatisfactory learning outcomes. The focus of this paper is on the structure of the curriculum but the content is also discussed when it has an effect on the structure and its implementation. The presented structure, i.e. DAS formalism, builds upon the ideas of some classical pedagogical theories, which have regularly been applied at course level but seldom used to solve curriculum-level issues.

  3. Vallabhaneni Sita Rama Das, 1933-2010: teacher and mentor.

    PubMed

    Elchuri, Sailaja V; Govindjee

    2016-05-01

    We present here the life and research of V. S. Rama Das, a distinguished Indian botanist who specialized in photosynthesis. He was the first to purify chloroplasts that were free of mitochondrial contamination. He then studied C4, C3-C4 intermediate and CAM pathways, as well as their taxonomic distribution in tropical climates. His most valuable legacy is that he, as a philosopher, inspired and guided many students to pursue their research career in India. Also see Narayana and Pullaiah (Eminent Indian Botanists: Past and present: Biographies and contributions, pp 394-401, 2010) and Raghavendra and Reddy (Curr Sci 101:798-799, 2011) for further information on Rama Das.

  4. The development of the disease activity score (DAS) and the disease activity score using 28 joint counts (DAS28).

    PubMed

    van Riel, P L C M

    2014-01-01

    In rheumatoid arthritis, disease activity cannot be measured using a single variable. The Disease Activity Score (DAS) has been developed as a quantitative index to be able to measure, study and manage disease activity in RA in daily clinical practice, clinical trials, and long term observational studies. The DAS is a continuous measure of RA disease activity that combines information from swollen joints, tender joints, acute phase response and patient self-report of general health. Cut points were developed to classify patients in remission, as well as low, moderate, and severe disease activity in the 1990s. DAS-based EULAR response criteria were primarily developed to be used in clinical trials to classify individual patients as non-, moderate, or good responders, depending on the magnitude of change and absolute level of disease activity at the conclusion of the test.

  5. ProServer: a simple, extensible Perl DAS server.

    PubMed

    Finn, Robert D; Stalker, James W; Jackson, David K; Kulesha, Eugene; Clements, Jody; Pettett, Roger

    2007-06-15

    The increasing size and complexity of biological databases has led to a growing trend to federate rather than duplicate them. In order to share data between federated databases, protocols for the exchange mechanism must be developed. One such data exchange protocol that is widely used is the Distributed Annotation System (DAS). For example, DAS has enabled small experimental groups to integrate their data into the Ensembl genome browser. We have developed ProServer, a simple, lightweight, Perl-based DAS server that does not depend on a separate HTTP server. The ProServer package is easily extensible, allowing data to be served from almost any underlying data model. Recent additions to the DAS protocol have enabled both structure and alignment (sequence and structural) data to be exchanged. ProServer allows both of these data types to be served. ProServer can be downloaded from http://www.sanger.ac.uk/proserver/ or CPAN http://search.cpan.org/~rpettett/. Details on the system requirements and installation of ProServer can be found at http://www.sanger.ac.uk/proserver/.

  6. On the Law of Inertia. Translation of: Ueber das Beharrungsgesetz

    NASA Astrophysics Data System (ADS)

    Lange, Ludwig

    2014-04-01

    This article is a translation of Ludwig Lange: "Ueber das Beharrungsgesetz" in: Berichte ueber Verhandlungen der Koenigl. Saechsischen Gesellschaft der Wissenschaften, math.-physik. Klasse (Leipzig, 1885), SS. 333-351. Translated by Herbert Pfister, Institut für Theoretische Physik, Universität Tübingen, Auf der Morgenstelle 14, 72076 Tübingen, Germany; herbert.pfister@uni-tuebingen.de. Kind assistance by Julian Barbour is acknowledged.

  7. Disease Activity Score 28 (DAS28) using C-reactive protein underestimates disease activity and overestimates EULAR response criteria compared with DAS28 using erythrocyte sedimentation rate in a large observational cohort of rheumatoid arthritis patients in Japan.

    PubMed

    Matsui, Toshihiro; Kuga, Yoshiaki; Kaneko, Atsushi; Nishino, Jinju; Eto, Yoshito; Chiba, Noriyuki; Yasuda, Masayuki; Saisho, Koichiro; Shimada, Kota; Tohma, Shigeto

    2007-09-01

    To compare disease activity and the improvement of disease activity evaluated between by Disease Activity Score 28 using erythrocyte sedimentation rate (DAS28-ESR) and by DAS28 using C-reactive protein (DAS28-CRP) in Japanese patients with rheumatoid arthritis (RA). Data from 3073 RA patients registered in the large cohort database (NinJa: National Database of Rheumatic Diseases by iR-net in Japan) of 2003 was used to calculate DAS28-ESR and DAS28-CRP and disease activities were evaluated. Improvements in disease activities were also evaluated according to the European League Against Rheumatism (EULAR) response criteria in 1482 RA patients whose DAS28-ESR and DAS28-CRP could be calculated from data for both 2002 and 2003. The mean value of DAS28-CRP (3.59, SD 1.25) was significantly smaller than that of mean DAS28-ESR (4.31, SD 1.32) (p < 0.0001). The number of patients who satisfied the criteria of remission was 297 (9.7%) in DAS28-ESR versus 705 (22.9%) in DAS28-CRP and the number of patients with high disease activity was 842 (27.4%) versus 357 (11.6%) for DAS28-ESR and DAS28-CRP, respectively; there was a significant difference between the two (p < 0.0001). Change of respective DAS28 was significantly correlated (DeltaDAS28-ESR -0.05, SD 1.14 versus DeltaDAS28-CRP -0.10, SD 1.10) (p < 0.0001); however, the number of "good response" patients was significantly different (p < 0.03) between DAS28-ESR (97 patients, 6.5%) and DAS28-CRP (136 patients, 9.2%). DAS28-CRP significantly underestimated disease activity and overestimated the improvement in disease activity compared with DAS28-ESR. DAS28-CRP should be evaluated using different criteria from that for DAS28-ESR.

  8. Host perception of jasmonates promotes infection by Fusarium oxysporum formae speciales that produce isoleucine- and leucine-conjugated jasmonates

    PubMed Central

    Cole, Stephanie J.; Yoon, Alexander J.; Faull, Kym F.; Diener, Andrew C.

    2014-01-01

    Summary Three pathogenic forms, or formae speciales, of Fusarium oxysporum infect the roots of Arabidopsis thaliana belowground, instigating symptoms of wilt disease in leaves aboveground. In prior reports, Arabidopsis mutants that are deficient in the biosynthesis of abscisic acid or salicylic acid or insensitive to ethylene or jasmonates exhibit more or less wilt disease than wild type, implicating the involvement of hormones in the normal host response to F. oxysporum. Our analysis of hormone-related mutants finds no evidence that endogenous hormones contribute to infection in roots. Mutants that are deficient in abscisic acid and insensitive to ethylene have no less infection than wild type, though they exhibit less disease. Whether a mutant that is insensitive to jasmonates affects infection depends on which forma specialis is infecting roots. Insensitivity to jasmonates suppresses infection by F. oxysporum forma specialis conglutinans and F. oxysporum forma specialis matthioli, which produce isoleucine- and leucine-conjugated jasmonate (JA-Ile/Leu) in culture filtrates; whereas, insensitivity to jasmonates has no effect on infection by F. oxysporum forma specialis raphani, which produces no detectable JA-Ile/Leu. Furthermore, insensitivity to jasmonates has no effect on wilt disease of tomato, and the tomato pathogen F. oxysporum forma specialis lycopersici produces no detectable jasmonates. Thus, some but not all F. oxysporum pathogens appear to utilize jasmonates as effectors, promoting infection in roots and/or development of symptoms in shoots. Only when infection of roots is promoted by jasmonates is wilt disease enhanced in a mutant deficient in salicylic acid biosynthesis. PMID:24387225

  9. Statistical Quality Control of Moisture Data in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D. P.; Rukhovets, L.; Todling, R.

    1999-01-01

    A new statistical quality control algorithm was recently implemented in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The final step in the algorithm consists of an adaptive buddy check that either accepts or rejects outlier observations based on a local statistical analysis of nearby data. A basic assumption in any such test is that the observed field is spatially coherent, in the sense that nearby data can be expected to confirm each other. However, the buddy check resulted in excessive rejection of moisture data, especially during the Northern Hemisphere summer. The analysis moisture variable in GEOS DAS is water vapor mixing ratio. Observational evidence shows that the distribution of mixing ratio errors is far from normal. Furthermore, spatial correlations among mixing ratio errors are highly anisotropic and difficult to identify. Both factors contribute to the poor performance of the statistical quality control algorithm. To alleviate the problem, we applied the buddy check to relative humidity data instead. This variable explicitly depends on temperature and therefore exhibits a much greater spatial coherence. As a result, reject rates of moisture data are much more reasonable and homogeneous in time and space.

  10. Statistical Quality Control of Moisture Data in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D. P.; Rukhovets, L.; Todling, R.

    1999-01-01

    A new statistical quality control algorithm was recently implemented in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The final step in the algorithm consists of an adaptive buddy check that either accepts or rejects outlier observations based on a local statistical analysis of nearby data. A basic assumption in any such test is that the observed field is spatially coherent, in the sense that nearby data can be expected to confirm each other. However, the buddy check resulted in excessive rejection of moisture data, especially during the Northern Hemisphere summer. The analysis moisture variable in GEOS DAS is water vapor mixing ratio. Observational evidence shows that the distribution of mixing ratio errors is far from normal. Furthermore, spatial correlations among mixing ratio errors are highly anisotropic and difficult to identify. Both factors contribute to the poor performance of the statistical quality control algorithm. To alleviate the problem, we applied the buddy check to relative humidity data instead. This variable explicitly depends on temperature and therefore exhibits a much greater spatial coherence. As a result, reject rates of moisture data are much more reasonable and homogeneous in time and space.

  11. Einfluss des Internets auf das Informations-, Einkaufs- und Verkehrsverhalten

    NASA Astrophysics Data System (ADS)

    Nerlich, Mark R.; Schiffner, Felix; Vogt, Walter

    Mit Daten aus eigenen Erhebungen können das einkaufsbezogene Informations- und Einkaufsverhalten im Zusammenhang mit den verkehrlichen Aspekten (Distanzen, Verkehrsmittel, Wegekopplungen) dargestellt werden. Die Differenzierung in die drei Produktkategorien des täglichen, mittelfristigen und des langfristigen Bedarfs berücksichtigt in erster Linie die Wertigkeit eines Gutes, die seine Erwerbshäufigkeit unmittelbar bestimmt. Der Einsatz moderner IKT wie das Internet eröffnet dem Endverbraucher neue Möglichkeiten bei Information und Einkauf. Die verkehrliche Relevanz von Online-Shopping wird deutlich, wenn man berücksichtigt, dass im Mittel rund 17% aller Online-Einkäufe, die die Probanden durchgeführt haben, Einkäufe in Ladengeschäften ersetzen. Dies gilt in verstärktem Maße für Online-Informationen: etwa die Hälfte hätte alternativ im stationären Einzelhandel stattgefunden. Da der Erwerb von Gütern des täglichen Bedarfs häufig nahräumlich und in relevantem Anteil nicht-motorisiert erfolgen kann, sind in diesem Segment - im Gegensatz zum mittel- und langfristigen Bedarf - nur geringe Substitutionseffekte zu beobachten.

  12. Influence of abscisic acid and sucrose on somatic embryogenesis in Cactus Copiapoa tenuissima Ritt. forma mostruosa.

    PubMed

    Lema-Rumińska, J; Goncerzewicz, K; Gabriel, M

    2013-01-01

    Having produced the embryos of cactus Copiapoa tenuissima Ritt. forma monstruosa at the globular stage and callus, we investigated the effect of abscisic acid (ABA) in the following concentrations: 0, 0.1, 1, 10, and 100  μ M on successive stages of direct (DSE) and indirect somatic embryogenesis (ISE). In the indirect somatic embryogenesis process we also investigated a combined effect of ABA (0, 0.1, 1  μ M) and sucrose (1, 3, 5%). The results showed that a low concentration of ABA (0-1  μ M) stimulates the elongation of embryos at the globular stage and the number of correct embryos in direct somatic embryogenesis, while a high ABA concentration (10-100  μ M) results in growth inhibition and turgor pressure loss of somatic embryos. The indirect somatic embryogenesis study in this cactus suggests that lower ABA concentrations enhance the increase in calli fresh weight, while a high concentration of 10  μ M ABA or more changes calli color and decreases its proliferation rate. However, in the case of indirect somatic embryogenesis, ABA had no effect on the number of somatic embryos and their maturation. Nevertheless, we found a positive effect of sucrose concentration for both the number of somatic embryos and the increase in calli fresh weight.

  13. Influence of Abscisic Acid and Sucrose on Somatic Embryogenesis in Cactus Copiapoa tenuissima Ritt. forma mostruosa

    PubMed Central

    Lema-Rumińska, J.; Goncerzewicz, K.; Gabriel, M.

    2013-01-01

    Having produced the embryos of cactus Copiapoa tenuissima Ritt. forma monstruosa at the globular stage and callus, we investigated the effect of abscisic acid (ABA) in the following concentrations: 0, 0.1, 1, 10, and 100 μM on successive stages of direct (DSE) and indirect somatic embryogenesis (ISE). In the indirect somatic embryogenesis process we also investigated a combined effect of ABA (0, 0.1, 1 μM) and sucrose (1, 3, 5%). The results showed that a low concentration of ABA (0-1 μM) stimulates the elongation of embryos at the globular stage and the number of correct embryos in direct somatic embryogenesis, while a high ABA concentration (10–100 μM) results in growth inhibition and turgor pressure loss of somatic embryos. The indirect somatic embryogenesis study in this cactus suggests that lower ABA concentrations enhance the increase in calli fresh weight, while a high concentration of 10 μM ABA or more changes calli color and decreases its proliferation rate. However, in the case of indirect somatic embryogenesis, ABA had no effect on the number of somatic embryos and their maturation. Nevertheless, we found a positive effect of sucrose concentration for both the number of somatic embryos and the increase in calli fresh weight. PMID:23843737

  14. Cytotoxic and ACAT-inhibitory sesquiterpene lactones from the root of Ixeris dentata forma albiflora.

    PubMed

    Ahn, Eun-Mi; Bang, Myun-Ho; Song, Myoung-Chong; Park, Mi-Hyun; Kim, Hwa-Young; Kwon, Byoung-Mog; Baek, Nam-In

    2006-11-01

    Ixeris dentata forma albiflora was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O. Eight sesquiterpenes were isolated through repeated silica gel and octadecyl silica gel (C18, ODS) column chromatography of the EtOAc and n-BuOH fractions. Physicochemical analysis using NMR, MS and IR revealed the chemical structures of the sesquiterpenes, which were zaluzanin (1), 9a-hydroxyguaian-4(15),10(14),11(13)-triene-6,12-olide (2), 3beta-O-beta-D-glucopyranosyl-8beta-hydroxyguaian-4(15),10(14)-diene-6,12-olide (3), 3-O-beta-D-glucopyranosyl-8beta-hydroxyguauan-10(14)-ene-6,12-olide (4), ixerin M (5), glucozaluzanin C (6), crepiside I (7), and ixerin D (8). This is the first time that these sesquiterpene lactones have been isolated from this plant. Compounds 1, 2 and 7 revealed relatively high cytotoxicities on human colon carcinoma cell and lung adenocarcinoma cell, while compounds 5 and 7 showed acyl-CoA: cholesterol acyltransferase (ACAT) inhibitory activity.

  15. M-DAS: System for multispectral data analysis. [in Saginaw Bay, Michigan

    NASA Technical Reports Server (NTRS)

    Johnson, R. H.

    1975-01-01

    M-DAS is a ground data processing system designed for analysis of multispectral data. M-DAS operates on multispectral data from LANDSAT, S-192, M2S and other sources in CCT form. Interactive training by operator-investigators using a variable cursor on a color display was used to derive optimum processing coefficients and data on cluster separability. An advanced multivariate normal-maximum likelihood processing algorithm was used to produce output in various formats: color-coded film images, geometrically corrected map overlays, moving displays of scene sections, coverage tabulations and categorized CCTs. The analysis procedure for M-DAS involves three phases: (1) screening and training, (2) analysis of training data to compute performance predictions and processing coefficients, and (3) processing of multichannel input data into categorized results. Typical M-DAS applications involve iteration between each of these phases. A series of photographs of the M-DAS display are used to illustrate M-DAS operation.

  16. M-DAS: System for multispectral data analysis. [in Saginaw Bay, Michigan

    NASA Technical Reports Server (NTRS)

    Johnson, R. H.

    1975-01-01

    M-DAS is a ground data processing system designed for analysis of multispectral data. M-DAS operates on multispectral data from LANDSAT, S-192, M2S and other sources in CCT form. Interactive training by operator-investigators using a variable cursor on a color display was used to derive optimum processing coefficients and data on cluster separability. An advanced multivariate normal-maximum likelihood processing algorithm was used to produce output in various formats: color-coded film images, geometrically corrected map overlays, moving displays of scene sections, coverage tabulations and categorized CCTs. The analysis procedure for M-DAS involves three phases: (1) screening and training, (2) analysis of training data to compute performance predictions and processing coefficients, and (3) processing of multichannel input data into categorized results. Typical M-DAS applications involve iteration between each of these phases. A series of photographs of the M-DAS display are used to illustrate M-DAS operation.

  17. Das Assessment von Vulnerabilitäten, Risiken und Unsicherheiten

    NASA Astrophysics Data System (ADS)

    Birkmann, Jörn; Greiving, Stefan; Serdeczny, Olivia Maria

    Die Risiken und möglichen Folgen des Klimawandels für Menschen, Produktions- und Ökosysteme sind eng mit sozioökonomischen Entwicklungen und Rahmenbedingungen verflochten. Die Schlüsselbegriffe "Vulnerabilität", "Risiko" und "Unsicherheit" werden näher beleuchtet, um u. a. deutlich zu machen, wie sie im neueren Risikoansatz des Fünften Sachstandsberichts (AR5) des Weltklimarats (IPCC) genutzt werden. Das Risikokonzept wird vom Vulnerabilitätskonzept unterschieden. In den Fokus rückt die Betrachtung von Gefahr und Exposition. Auch die Frage, was unter Unsicherheit und Bandbreiten möglicher Entwicklungen des Klimas und sogenannter sozioökonomischer Entwicklungspfade zu verstehen ist, spielt dabei eine wichtige Rolle. Bisherige Untersuchungsmethoden zu Risiken im Kontext des Klimawandels und darauf aufbauende Entscheidungsprozesse werden im Hinblick auf künftige Anpassungsmaßnahmen diskutiert.

  18. Das Semantic Web als Werkzeug in der biomedizinischen Forschung

    NASA Astrophysics Data System (ADS)

    Stenzhorn, Holger; Samwald, Matthias

    In der biomedizinischen Forschung werden besonders in den letzten Jahren vermehrt enorme Mengen an neuen Daten produziert und diese in Folge verstärkt per Internet veröffentlicht. Viele Experten sehen in dieser Vorgehensweise die Chance zur Entdeckung bisher unbekannter biomedizinischer Erkenntnisse. Um dies jedoch zu ermöglichen, müssen neue Wege gefunden werden, die gewonnenen Daten effizient zu verarbeiten und zu verwalten. In dem vorliegenden Artikel werden die Möglichkeiten betrachtet, die das Semantic Web hierzu anbieten kann. Hierfür werden die relevanten Technologien des Semantic Web im speziellen Kontext der biomedizinischen Forschung betrachtet. Ein Fokus liegt auf der Anwendung von Ontologien in der Biomedizin: Es wird auf deren Vorteile eingegangen, aber auch auf möglichen Probleme, die deren Einsatz in einem erweiterten wissenschaftlichen Umfeld mit sich bringen können.

  19. Ensino de astronomia e óptica: é possível fazê-lo de forma contextualizada no nível médio?

    NASA Astrophysics Data System (ADS)

    Sobrinho, A. A.; Jafelice, L. C.

    2003-08-01

    Discutimos nossa participação em um curso de treinamento para professores de diversas disciplinas do ensino médio. Nossa preocupação básica foi desenvolver instrumentos educacionais adequados para levar à sala de aula, nesse nível de ensino, de forma contextualizada, questionamentos freqüentes dos alunos sobre astronomia e sua relação com tecnologia e sociedade. Encaminhamos questões como: a evolução da astronomia, suas relações com outros ramos do conhecimento humano e conseqüentes aplicações; avanços na tecnologia dos instrumentos ópticos versus a importância da observação do céu a olho nu; a relação entre olho humano, luneta e telescópio; e desenvolvimento da tecnologia espacial e sua influência em nosso cotidiano. Objetivamos com isto fazer um resgate histórico e pedagógico das aplicações e observações do céu no cenário escolar, destacando a relação entre eventos astronômicos, olho humano, instrumentos mediadores e suas contextualizações históricas e sociais. Produtos desta abordagem foram o desenvolvimento e a adaptação de práticas e materiais instrucionais diversos (e.g., "espelhos" de isopor e "raios luminosos" de bolinhas de gude; montagens envolvendo velas, lasers, lentes e espelhos; desmonte e análise de peças de um telescópio; etc.). Além disto, como outro resultado deste trabalho, elaboramos textos sobre história da astronomia e da óptica para atividades em classe. Com estas ações visamos facilitar a concretização de conceitos físicos envolvidos, exemplificar um ensino contextualizado e interdisciplinar motivado por temas astronômicos e favorecer que práticas e discussões feitas com os treinandos possam ser transpostas para a sala de aula. A reação dos professores às práticas propostas foi bastante positiva. Todos esses aspectos são discutidos em detalhe neste trabalho. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP)

  20. The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis.

    PubMed

    van Riel, Piet L C M; Renskers, Lisanne

    2016-01-01

    In rheumatoid arthritis (RA), disease activity cannot be measured in all individual patients according to a single variable. The Disease Activity Score (DAS) and the DAS28 have been developed to measure disease activity in RA both in daily clinical practice as well as in clinical trials on a group as well as individual level. The DAS/DAS28 is a continuous measure of RA disease activity that combines information from swollen joints, tender joints, acute phase response and general health. The DAS-based EULAR response criteria were primarily developed to be used in clinical trials. The EULAR response criteria classify individual patients as non-, moderate, or good responders, dependent on the magnitude of change and level of disease activity reached. In addition, already in the early nineties, cut points were developed to categorise patients in remission. The DAS28 is incorporated in several electronic patient records and web-based systems for monitoring purposes in daily clinical practice. In addition to this, it is being used in combination with patient-reported outcome measures (PROMs) to facilitate self-monitoring.

  1. Detecting Changes Following the Provision of Assistive Devices: Utility of the WHO-DAS II

    ERIC Educational Resources Information Center

    Raggi, Alberto

    2010-01-01

    The World Health Organization Disability Assessment Schedule II (WHO-DAS II) is a non-disease-specific International Classification of Functioning, Disability, and Health-based disability assessment instrument developed to measure activity limitations and restrictions to participation. The aim of this pilot study is to evaluate WHO-DAS II…

  2. Psychometric Properties of the Disability Assessment Schedule (DAS) for Behavior Problems: An Independent Investigation

    ERIC Educational Resources Information Center

    Tsakanikos, Elias; Underwood, Lisa; Sturmey, Peter; Bouras, Nick; McCarthy, Jane

    2011-01-01

    The present study employed the Disability Assessment Schedule (DAS) to assess problem behaviors in a large sample of adults with ID (N = 568) and evaluate the psychometric properties of this instrument. Although the DAS problem behaviors were found to be internally consistent (Cronbach's [alpha] = 0.87), item analysis revealed one weak item…

  3. Detecting Changes Following the Provision of Assistive Devices: Utility of the WHO-DAS II

    ERIC Educational Resources Information Center

    Raggi, Alberto

    2010-01-01

    The World Health Organization Disability Assessment Schedule II (WHO-DAS II) is a non-disease-specific International Classification of Functioning, Disability, and Health-based disability assessment instrument developed to measure activity limitations and restrictions to participation. The aim of this pilot study is to evaluate WHO-DAS II…

  4. Psychometric Properties of the Disability Assessment Schedule (DAS) for Behavior Problems: An Independent Investigation

    ERIC Educational Resources Information Center

    Tsakanikos, Elias; Underwood, Lisa; Sturmey, Peter; Bouras, Nick; McCarthy, Jane

    2011-01-01

    The present study employed the Disability Assessment Schedule (DAS) to assess problem behaviors in a large sample of adults with ID (N = 568) and evaluate the psychometric properties of this instrument. Although the DAS problem behaviors were found to be internally consistent (Cronbach's [alpha] = 0.87), item analysis revealed one weak item…

  5. Das Programm Oder 2006. Hochwasserschutz in Polen im Zuge der EU-Osterweiterung

    NASA Astrophysics Data System (ADS)

    Kühne, Olaf

    Hochwasser ist ein natürliches Ereignis: Seit jeher sind die Menschen mit Hochwasser und seinen Auswirkungen konfrontiert. Das Ausmaß von Hochwasser reicht dabei von Straßenüberschwemmungen bis zur Überflutung ganzer Landesteile. Auch im Oderflußsystem waren und sind Überschwemmungen keine Seltenheit, in den letzten 200 Jahren ereigneten sie sich in den Jahren 1813, 1838, 1854, 1870, 1903, 1958, 1965, 1970, 1972, 1977, 1981, 1985 und 1997. Das Hochwasser von 1997 war jedoch das schwerste im genannten Zeitraum. Als Reaktion auf das Hochwasser von 1997 wurde in der betroffenen Region das Programm 〝Oder 2006`` entwickelt. Mit seiner Hilfe sollen die Auswirkungen künftiger Hochwasserereignisse abgeschwächt werden.

  6. Disease Activity Score 28 (DAS28) using C‐reactive protein underestimates disease activity and overestimates EULAR response criteria compared with DAS28 using erythrocyte sedimentation rate in a large observational cohort of rheumatoid arthritis patients in Japan

    PubMed Central

    Matsui, Toshihiro; Kuga, Yoshiaki; Kaneko, Atsushi; Nishino, Jinju; Eto, Yoshito; Chiba, Noriyuki; Yasuda, Masayuki; Saisho, Koichiro; Shimada, Kota; Tohma, Shigeto

    2007-01-01

    Objectives To compare disease activity and the improvement of disease activity evaluated between by Disease Activity Score 28 using erythrocyte sedimentation rate (DAS28‐ESR) and by DAS28 using C‐reactive protein (DAS28‐CRP) in Japanese patients with rheumatoid arthritis (RA). Methods Data from 3073 RA patients registered in the large cohort database (NinJa: National Database of Rheumatic Diseases by iR‐net in Japan) of 2003 was used to calculate DAS28‐ESR and DAS28‐CRP and disease activities were evaluated. Improvements in disease activities were also evaluated according to the European League Against Rheumatism (EULAR) response criteria in 1482 RA patients whose DAS28‐ESR and DAS28‐CRP could be calculated from data for both 2002 and 2003. Results The mean value of DAS28‐CRP (3.59, SD 1.25) was significantly smaller than that of mean DAS28‐ESR (4.31, SD 1.32) (p < 0.0001). The number of patients who satisfied the criteria of remission was 297 (9.7%) in DAS28‐ESR versus 705 (22.9%) in DAS28‐CRP and the number of patients with high disease activity was 842 (27.4%) versus 357 (11.6%) for DAS28‐ESR and DAS28‐CRP, respectively; there was a significant difference between the two (p < 0.0001). Change of respective DAS28 was significantly correlated (ΔDAS28‐ESR −0.05, SD 1.14 versus ΔDAS28‐CRP −0.10, SD 1.10) (p < 0.0001); however, the number of “good response” patients was significantly different (p < 0.03) between DAS28‐ESR (97 patients, 6.5%) and DAS28‐CRP (136 patients, 9.2%). Conclusions DAS28‐CRP significantly underestimated disease activity and overestimated the improvement in disease activity compared with DAS28‐ESR. DAS28‐CRP should be evaluated using different criteria from that for DAS28‐ESR. PMID:17369281

  7. How to specify and measure sensitivity in Distributed Acoustic Sensing (DAS)?

    NASA Astrophysics Data System (ADS)

    Gabai, Haniel; Eyal, Avishay

    2017-04-01

    In Rayleigh-scattering-based Distributed Acoustic Sensing (DAS) an optical fiber is transformed into an array of thousands of 'virtual microphones'. This approach has gained tremendous popularity in recent years and is one of the most successful examples of a fiber-optic sensing method which made its way from the academia to the market. Despite the great amount of work done in this field, sensitivity, which is ones of the most critical parameters of any sensing technique, was rarely investigated in this context. In particular, little attention was given to its random characteristics. Without careful consideration of the random aspects of DAS, any attempt to specify its sensitivity or to compare between different DAS modalities is of limited value. Recently we introduced a new statistical parameter which defines DAS sensitivity and enables comparison between the performances of different DAS systems. In this paper we generalize the previous parameter and give a broader, simple and intuitive definition to DAS sensitivity. An important attribute of these parameters is that they can be easily extracted from the static backscatter profile of the sensing fiber. In the paper we derive the relation between DAS sensitivity and the static backscatter profile and present an experimental verification of this relation.

  8. DasR positively controls monensin production at two-level regulation in Streptomyces cinnamonensis.

    PubMed

    Zhang, Yue; Lin, Chun-Yan; Li, Xiao-Mei; Tang, Zheng-Kun; Qiao, Jianjun; Zhao, Guang-Rong

    2016-12-01

    The polyether ionophore antibiotic monensin is produced by Streptomyces cinnamonensis and is used as a coccidiostat for chickens and growth-promoting agent for cattle. Monensin biosynthetic gene cluster has been cloned and partially characterized. The GntR-family transcription factor DasR regulates antibiotic production and morphological development in Streptomyces coelicolor and Saccharopolyspora erythraea. In this study, we identified and characterized the two-level regulatory cascade of DasR to monensin production in S. cinnamonensis. Forward and reverse genetics by overexpression and antisense RNA silence of dasR revealed that DasR positively controls monensin production under nutrient-rich condition. Electrophoresis mobility shift assay (EMSA) showed that DasR protein specifically binds to the promoter regions of both pathway-specific regulatory gene monRII and biosynthetic genes monAIX, monE and monT. Semi-quantitative RT-PCR further confirmed that DasR upregulates the transcriptional levels of these genes during monensin fermentation. Subsequently, co-overexpressed dasR with pathway-specific regulatory genes monRI, monRII or monH greatly improved monensin production.

  9. Crosslinking effect of dialdehyde starch (DAS) on decellularized porcine aortas for tissue engineering.

    PubMed

    Wang, Xu; Gu, Zhipeng; Qin, Huanhuan; Li, Li; Yang, Xu; Yu, Xixun

    2015-08-01

    Biological tissue-derived biomaterials must be chemically modified to avoid immediate degradation and immune response before being implanted in human body to replace malfunctioning organs. DAS with active aldehyde groups was employed to replace glutaraldehyde (GA), a most common synthetic crosslinking reagent in clinical practice, to fix bioprostheses for lower cytotoxicity. The aim of this research was to evaluate fixation effect of DAS. The tensile strength, crosslinking stability, cytotoxicity especially the anti-calcification capability of DAS-fixed tissues were investigated. The tensile strength and resistance to enzymatic degradation of samples were increased after DAS fixation, the values maintained stably in D-Hanks solution for several days. Meanwhile, ultrastructure of samples preserved well and the anti-calcification capability of samples were improved, the amount of positive staining points in the whole visual field of 15% DAS-fixed samples was only 0.576 times to GA-fixed ones. Moreover, both unreacted DAS and its hydrolytic products were nontoxic in cytotoxicity study. The results demonstrated DAS might be an effective crosslinking reagent to fix biological tissue-derived biomaterials in tissue engineering. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Compositional safety of herbicide-tolerant DAS-81910-7 cotton.

    PubMed

    Herman, Rod A; Fast, Brandon J; Johnson, Tempest Y; Sabbatini, Jane; Rudgers, Gary W

    2013-11-27

    DAS-81910-7 cotton is a transgenic event that was transformed to contain the aad-12 and pat genes. These genes code for the AAD-12 and PAT proteins, which confer tolerance to the herbicides 2,4-D and glufosinate, respectively. Crop composition studies were conducted with DAS-81910-7 cotton (both nonsprayed and sprayed with 2,4-D and glufosinate) to comply with requirements of regulatory authorities responsible for evaluating crop safety. Results indicate compositional equivalence between DAS-81910-7 cottonseed and nontransgenic cottonseed and between sprayed and nonsprayed DAS-81910-7 cottonseed. This study builds on the results from many prior studies which support the conclusion that transgenesis is less likely to unexpectedly alter the composition of crops as compared with traditional breeding.

  11. Phase 1 Clinical Trials of DAS181, an Inhaled Sialidase, in Healthy Adults

    PubMed Central

    Zenilman, Jonathan M.; Fuchs, Edward J.; Hendrix, Craig W.; Radebaugh, Christine; Jurao, Robert; Nayak, Seema U.; Hamilton, Robert G.; Griffiss, J. McLeod

    2015-01-01

    DAS181, (study drug, Fludase®) was developed for treatment of influenza and parainfluenza infections. Delivered by inhalation, DAS181 cleaves sialic acid receptors from respiratory epithelial cells. Treatment of influenza for three days with DAS181 reduced viral shedding. To increase deposition in the upper airways and decrease systemic absorption, the particle size was increased to 10 microns. We conducted two Phase I trials with three cohorts, randomized 2:1, active drug to placebo. The initial cohort got a single 20 mg dose of DAS181, or placebo; the second, 20 mg DAS181 or placebo for 10 days, and the third got 20 mg of DAS181or placebo for 3 days. Formulations differed slightly in their excipients. Subjects in the 1- and 3-day cohorts completed dosing without serious adverse events. Two subjects in the 10-day cohort stopped at Day 9 after developing respiratory and systemic symptoms, and a third experienced a decrease in FEV1 (Forced Expiratory Volume in 1 second) after the 9th dose and a further decline after the 10th dose. Plasma DAS181, in the 10-day cohort, peaked and began falling before the last dose. Antibodies, predominately IgG with neutralizing activity, were detected in 15/18 subjects by Day 30. The highest IgG concentrations were in the 10-day cohort. The respiratory adverse events occurring after seven days and rapid drug clearance during continued dosing are consistent with the induction of DAS181 antibodies. This could preclude use of this medication for longer than seven days or for repeated courses. (These studies have been registered at ClinicalTrials.gov under registration nos. NCT 00527865 and NCT 01651494.) PMID:26391974

  12. Phase 1 clinical trials of DAS181, an inhaled sialidase, in healthy adults.

    PubMed

    Zenilman, Jonathan M; Fuchs, Edward J; Hendrix, Craig W; Radebaugh, Christine; Jurao, Robert; Nayak, Seema U; Hamilton, Robert G; McLeod Griffiss, J

    2015-11-01

    DAS181, (study drug, Fludase®) was developed for treatment of influenza and parainfluenza infections. Delivered by inhalation, DAS181 cleaves sialic acid receptors from respiratory epithelial cells. Treatment of influenza for three days with DAS181 reduced viral shedding. To increase deposition in the upper airways and decrease systemic absorption, the particle size was increased to 10μm. We conducted two Phase I trials with three cohorts, randomized 2:1, active drug to placebo. The initial cohort got a single 20mg dose of DAS181, or placebo; the second, 20mg DAS181 or placebo for 10days, and the third got 20mg of DAS181 or placebo for 3days. Formulations differed slightly in their excipients. Subjects in the 1- and 3-day cohorts completed dosing without serious adverse events. Two subjects in the 10-day cohort stopped at Day 9 after developing respiratory and systemic symptoms, and a third experienced a decrease in FEV1 (Forced Expiratory Volume in 1s) after the 9th dose and a further decline after the 10th dose. Plasma DAS181, in the 10-day cohort, peaked and began falling before the last dose. Antibodies, predominately IgG with neutralizing activity, were detected in 15/18 subjects by Day 30. The highest IgG concentrations were in the 10-day cohort. The respiratory adverse events occurring after seven days and rapid drug clearance during continued dosing are consistent with the induction of DAS181 antibodies. This could preclude use of this medication for longer than seven days or for repeated courses. (These studies have been registered at ClinicalTrials.gov under registration Nos. NCT 00527865 and NCT 01651494.).

  13. Development of a Driver Alert System (DAS) for the Bradley Fighting Vehicle

    DTIC Science & Technology

    1988-07-01

    FIGHTING VEHICLE The survivability of a Bradley Fighting Vehicle (BFV) depends, in large part, on rapid response and movement in changing battle conditions...ARI Research Note 88-73 I6 0 Development of aDriver AertSystem CO (DAS) for the Bradley Fighting Vehicle * David F. Champion, Paul R. Roberson, and...System (DAS) Final Report for the Bradley Fighting Vehicle September 85 - September 87 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(s) 6. CONTRACT OR GRANT

  14. Método numérico das diferenças finitas no domínio do tempo aplicado a ondas Alfvén em plasma astrofísico

    NASA Astrophysics Data System (ADS)

    Dos Santos, L. C.; Kintopp, J. A.; Jatenco-Pereira, V.; Opher, R.

    2003-08-01

    Ondas Alfvén em plasma astrofísico têm sido objeto de intenso estudo nas últimas décadas pelo fato de apresentarem papel importante em muitas áreas de pesquisa na astrofísica. Particularmente são importantes no mecanismo de aquecimento da coroa solar; em ventos estelares; em jatos galácticos e extragalácticos; em discos protoestelares, etc. A formulação para diferenças finitas no domínio do tempo (FDTD), aplicada a plasma magnetizado é desenvolvida para estudo das propriedades de ondas Alfvén em três dimensões (3D-FDTD). O método é aplicado inicialmente a um plasma homogêneo e isotérmico imerso em uma região com campo magnético externo B0, que sofre uma pequena perturbação. Uma vez gerada a onda, esta perturbação é retirada e, então analisamos a evolução temporal das ondas, bem como a forma de seu amortecimento.

  15. VIIRS ocean color data visualization and processing with IDL-based NOAA-SeaDAS

    NASA Astrophysics Data System (ADS)

    Wang, Xiaolong; Liu, Xiaoming; Jiang, Lide; Wang, Menghua; Sun, Junqiang

    2014-11-01

    The NOAA Sea-viewing Data Analysis System (NOAA-SeaDAS) is an Interactive Data Language (IDL)-based satellite data visualization, analysis, and processing system based on the version 6.4 of the NASA's Sea-viewing Wide Field-ofview (SeaWiFS) Data Analysis System (SeaDAS) released in 2012. NOAA-SeaDAS inherited all the original functionalities of SeaDAS 6.4 and was upgraded with many new functions and new sensor supports, particularly the support of the Visible Infrared Imaging Radiometer Suite (VIIRS) onboard the Suomi National Polar-Orbiting Partnership (SNPP). The main goal of the NOAA-SeaDAS development is primarily in support of NOAA ocean color team's calibration and validation activities. The current version of NOAA-SeaDAS can visualize, analyze, and process VIIRS Sensor Data Records (SDR or Level-1B data) produced by the NOAA Interface Data Processing System (IDPS), ocean color Environmental Data Records (EDR or Level-2 data) produced by the NOAA Multi-Sensor Level-1 to Level- 2 (MSL12) ocean color data processing system, and Level-3 data binned or mapped from Level-2 data produced by NOAA-MSL12. NOAA-SeaDAS is currently serving an active IDL user group at NOAA and will serve other institutions and universities in the future. The goal is to allow various scientific users to visualize, analyze, and process VIIRS data from Level-1B through Level-2 and Level-3. In addition, NOAA-SeaDAS can also visualize satellite images from the Korean Geostationary Ocean Color Imager (GOCI), as well as many other satellite ocean color sensors, e.g., SeaWiFS, the Moderate Resolution Imaging Spectroradiometer (MODIS), etc. NOAA-SeaDAS is under constant development to create new system functionalities and enhance user experience. With constantly increasing volume in the global ocean color data archive, NOAA-SeaDAS will play an important role in support of global marine environment data analysis and various scientific applications.

  16. Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein.

    PubMed

    Triana-Baltzer, Gallen B; Gubareva, Larisa V; Klimov, Alexander I; Wurtman, David F; Moss, Ronald B; Hedlund, Maria; Larson, Jeffrey L; Belshe, Robert B; Fang, Fang

    2009-11-06

    Antiviral drug resistance for influenza therapies remains a concern due to the high prevalence of H1N1 2009 seasonal influenza isolates which display H274Y associated oseltamivir-resistance. Furthermore, the emergence of novel H1N1 raises the potential that additional reassortments can occur, resulting in drug resistant virus. Thus, additional antiviral approaches are urgently needed. DAS181 (Fludase), a sialidase fusion protein, has been shown to have inhibitory activity against a large number of seasonal influenza strains and a highly pathogenic avian influenza (HPAI) strain (H5N1). Here, we examine the in vitro activity of DAS181 against a panel of 2009 oseltamivir-resistant seasonal H1N1 clinical isolates. The activity of DAS181 against nine 2009, two 2007, and two 2004 clinical isolates of seasonal IFV H1N1 was examined using plaque number reduction assay on MDCK cells. DAS181 strongly inhibited all tested isolates. EC50 values remained constant against isolates from 2004, 2007, and 2009, suggesting that there was no change in DAS181 sensitivity over time. As expected, all 2007 and 2009 isolates were resistant to oseltamivir, consistent with the identification of the H274Y mutation in the NA gene of all these isolates. Interestingly, several of the 2007 and 2009 isolates also exhibited reduced sensitivity to zanamivir, and accompanying HA mutations near the sialic acid binding site were observed. DAS181 inhibits IFV that is resistant to NAIs. Thus, DAS181 may offer an alternative therapeutic option for seasonal or pandemic IFVs that become resistant to currently available antiviral drugs.

  17. Two new steroidal saponins from dried fermented residues of leaf-juices of Agave sisalana forma Dong No. 1.

    PubMed

    Ding, Y; Tian, R H; Yang, C R; Chen, Y Y; Nohara, T

    1993-03-01

    In a previous paper, we reported the isolation and structure determination of three new steroidal saponins, dongnosides C (3), D (2) and E (1) from the dried fermented residues of leaf-juices of Agave sisalana forma Dong No. 1. In a continuing study on this plant, two additional new major steroidal saponins, named dongnosides B (4) and A (5), were obtained. Their structures were characterized respectively as tigogenin 3-O-alpha-L-rhamonpyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->2)- [beta-D- glucopyranosyl-(1-->3)]-beta-D-glucopyranosyl-(1-->4)-beta-D-galactop yranoside and 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->2)-[beta- D- xylopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->3)]-beta-D- glucopyranosyl-(1-->4)-beta-D-galactopyranoside on the basis of chemical and physicochemical evidence.

  18. BOOK REVIEW: Geheimnisvolles Universum - Europas Astronomen entschleiern das Weltall

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Lorenzen, D. H.

    2002-12-01

    The 25th birthday of ESO, in 1987, was celebrated by the publication of an illustrated popular book, "Exploring the Southern Sky" (Springer-Verlag 1987), which also saw editions in Danish, English, French, German, and Spanish. Written and illustrated by the ESO staff members Svend Laustsen, Claus Madsen and Richard M. West, its many pictures were mainly taken with the ESO 3.6m and Schmidt telescopes. The structure of the book - perhaps at that time somewhat unusual - started with things far away (Universe and galaxies), zoomed in to the Milky Way, and finally reached the Solar System (with a concluding chapter dealing with the La Silla observatory). Now, with the 4 units of the Very Large Telescope in full operation, and on the occasion of ESO's 40th birthday, another jubilee book has appeared: "Geheimnisvolles Universum: Europas Astronomen entschleiern das Weltall", written by the science journalist Dirk H. Lorenzen, of Hamburg, Germany, and prefaced by Catherine Cesarsky, Director General of ESO. Presumably, this book will also soon become available in more languages spoken in ESO member countries. Thus it may be worthwhile to review the first edition, although some readers may like to wait for more easily accessible editions. Before going into details, let me first mention that I find this a very impressing book, great to look at and refreshing to read. With ESO seen through the eyes of a visitor, things gain a perspective that is quite different from that of the previous book, and at least as attractive. It comes as no surprise that the book starts with a visit of ESO's showcase, the Paranal Observatory, and the writer not only notes down his own impressions, but also cites statements of some of the many people that keep Paranal going - technicians and staff astronomers. This mixture of texts provides a good impression of the operations at a large observatory for the general reader. The two more 'astronomical' parts that follow deal with star and planet

  19. Host perception of jasmonates promotes infection by Fusarium oxysporum formae speciales that produce isoleucine- and leucine-conjugated jasmonates.

    PubMed

    Cole, Stephanie J; Yoon, Alexander J; Faull, Kym F; Diener, Andrew C

    2014-08-01

    Three pathogenic forms, or formae speciales (f. spp.), of Fusarium oxysporum infect the roots of Arabidopsis thaliana below ground, instigating symptoms of wilt disease in leaves above ground. In previous reports, Arabidopsis mutants that are deficient in the biosynthesis of abscisic acid or salicylic acid or insensitive to ethylene or jasmonates exhibited either more or less wilt disease, than the wild-type, implicating the involvement of hormones in the normal host response to F. oxysporum. Our analysis of hormone-related mutants finds no evidence that endogenous hormones contribute to infection in roots. Mutants that are deficient in abscisic acid and insensitive to ethylene show no less infection than the wild-type, although they exhibit less disease. Whether a mutant that is insensitive to jasmonates affects infection depends on which forma specialis (f. sp.) is infecting the roots. Insensitivity to jasmonates suppresses infection by F. oxysporum f. sp. conglutinans and F. oxysporum f. sp. matthioli, which produce isoleucine- and leucine-conjugated jasmonate (JA-Ile/Leu), respectively, in culture filtrates, whereas insensitivity to jasmonates has no effect on infection by F. oxysporum f. sp. raphani, which produces no detectable JA-Ile/Leu. Furthermore, insensitivity to jasmonates has no effect on wilt disease of tomato, and the tomato pathogen F. oxysporum f. sp. lycopersici produces no detectable jasmonates. Thus, some, but not all, F. oxysporum pathogens appear to utilize jasmonates as effectors, promoting infection in roots and/or the development of symptoms in shoots. Only when the infection of roots is promoted by jasmonates is wilt disease enhanced in a mutant deficient in salicylic acid biosynthesis. © 2014 BSPP AND JOHN WILEY & SONS LTD.

  20. Global Gridded Data from the Goddard Earth Observing System Data Assimilation System (GEOS-DAS)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The Goddard Earth Observing System Data Assimilation System (GEOS-DAS) timeseries is a globally gridded atmospheric data set for use in climate research. This near real-time data set is produced by the Data Assimilation Office (DAO) at the NASA Goddard Space Flight Center in direct support of the operational EOS instrument product generation from the Terra (12/1999 launch), Aqua (05/2002 launch) and Aura (01/2004 launch) spacecrafts. The data is archived in the EOS Core System (ECS) at the Goddard Earth Sciences Data and Information Services Center/Distributed Active Archive Center (GES DISC DAAC). The data is only a selection of the products available from the GEOS-DAS. The data is organized chronologically in timeseries format to facilitate the computation of statistics. GEOS-DAS data will be available for the time period January 1, 2000, through present.

  1. Amerikas Einschätzung der deutschen Atomforschung: Das deutsche Uranprojekt

    NASA Astrophysics Data System (ADS)

    Walker, Mark

    2002-07-01

    Die amerikanischen Wissenschaftler und ihre emigrierten Kollegen, die am Bau der Atombombe beteiligt waren, verfügten über sehr widersprüchliche und großteils falsche Informationen über den Fortschritt des deutschen Uranprogramms. Noch nach Kriegsende lässt sich dies an Aussagen des Leiters der amerikanischen Alsos-Mission, Samuel Goudsmit, festmachen. Tatsächlich war das deutsche Programm hinsichtlich seiner wissenschaftlichen Grundlagen und des Managements nicht so unterlegen, wie vielfach behauptet wurde. Aber die deutschen Behörden waren nicht in der Lage, Geld und Ressourcen in gleichem Maße in das Uranprojekt zu investieren, wie etwa in das Peenemünder Raketenprojekt.

  2. DasR is a pleiotropic regulator required for antibiotic production, pigment biosynthesis, and morphological development in Saccharopolyspora erythraea.

    PubMed

    Liao, Cheng-Heng; Xu, Ya; Rigali, Sébastien; Ye, Bang-Ce

    2015-12-01

    The GntR-family transcription regulator, DasR, was previously identified as pleiotropic, controlling the primary amino sugar N-acetylglucosamine (GlcNAc) and chitin metabolism in Saccharopolyspora erythraea and Streptomyces coelicolor. Due to the remarkable regulatory impact of DasR on antibiotic production and development in the model strain of S. coelicolor, we here identified and characterized the role of DasR to secondary metabolite production and morphological development in industrial erythromycin-producing S. erythraea. The physiological studies have shown that a constructed deletion of dasR in S. erythraea resulted in antibiotic, pigment, and aerial hyphae production deficit in a nutrient-rich condition. DNA microarray assay, combined with quantitative real-time reverse transcription PCR (qRT-PCR), confirmed these results by showing the downregulation of the genes relating to secondary metabolite production in the dasR null mutant. Notably, electrophoretic mobility shift assays (EMSA) showed DasR as being the first identified regulator that directly regulates the pigment biosynthesis rpp gene cluster. In addition, further studies indicated that GlcNAc, the major nutrient signal of DasR-responsed regulation, blocked secondary metabolite production and morphological development. The effects of GlcNAc were shown to be caused by DasR mediation. These findings demonstrated that DasR is an important pleiotropic regulator for both secondary metabolism and morphological development in S. erythraea, providing new insights for the genetic engineering of S. erythraea with increased erythromycin production.

  3. Psychometric properties of the Death Anxiety Scale (DAS) among terminally ill cancer patients.

    PubMed

    Royal, Kenneth D; Elahi, Fereshte

    2011-01-01

    Research conducted with the terminally ill population in relation to death anxiety is rare and mostly outdated. The purpose of this study was to evaluate the psychometric properties of the widely used Death Anxiety Scale (DAS) on a sample of terminal cancer patients.Additionally, validation studies of the DAS have exclusively used traditional statistical methods for analysis. The current study utilized an item response theory technique (IRT), namely the Rasch Rating Scale model for data analysis. The methodology employed may be useful for other researchers conducting validation studies from an IRT perspective.

  4. PoroTomo: Map of DAS, Nodal, Vibroseis and Reftek Station Deployment

    SciTech Connect

    Kurt Feigl

    2016-10-15

    Map of DAS, nodal, vibroseis and Reftek stations during March 2016 deployment. The plot on the left has nodal stations labeled; the plot on the right has vibroseis observations labeled. Stations are shown in map-view using Brady's rotated X-Y coordinates with side plots denoting elevation with respect to the WGS84 ellipsoid. Blue circles denote vibroseis data, x symbols denote DAS (cyan for horizontal and magenta for vertical), black asterisks denote Reftek data, and red plus signs denote nodal data. This map can be found on UW-Madison's askja server at /PoroTomo/DATA/MAPS/Deployment_Stations.pdf

  5. The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

    PubMed Central

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales, and construct validity was established by demonstrating that the DAS could discriminate groups based on parental hearing status, school background, and use of self-labels. Construct validity was further demonstrated through factorial analyses, and findings resulted in a final 58-item measure. Directions for future research are discussed. PMID:21263041

  6. Das Lob der Sternkunst. Astronomie in der deutschen Aufklärung.

    NASA Astrophysics Data System (ADS)

    Baasner, R.

    Contents: 1. Einleitung. 2. Die Astronomie im Rahmen der Aufklärungs-Physik. 3. Das Lob der Sternkunst. 4. Ein Blick auf die Sternwarten. 5. Allgemeine Darstellungen der Sternkunde. 6. Schleppende Rezeption: Das kopernikanische Weltbild. 7. Himmelsphysik: Die Debatte um die causa gravitatis. 8. Theorie der Himmelskörper. 9. Die Erde als Gegenstand der Astronomie. 10. Die Sonne. 11. Der Mond. 12. Die Planeten. 13. Die Kometen. 14. Die Fixsterne. 15. Die Entstehung der Welt. 16. Beiträge der Astrotheologie. 17. Der Kampf gegen die Astrologen.

  7. An exploratory analysis of the factor structure of the Dysfunctional Attitude Scale-Form A (DAS).

    PubMed

    Moore, Michael T; Fresco, David M; Segal, Zindel V; Brown, Timothy A

    2014-10-01

    A number of studies have attempted to identify the factor structure of the Dysfunctional Attitude Scale (DAS). However, no studies have done so using a clinical sample of outpatients likely to generalize to the clinical trials in which the DAS is commonly used. The current investigation utilized exploratory structural equation modeling in an outpatient sample (N = 982) and found support for a one-factor solution (composed of 19 items). This solution was largely confirmed in a second outpatient sample (N = 301). Construct validity was demonstrated in correlations with measures of depression, social interaction anxiety, and symptoms of obsessive-compulsive disorder. © The Author(s) 2014.

  8. Das Prinzip Bewegung - Herz und Gehirn als Metaphern des menschlichen Lebens

    NASA Astrophysics Data System (ADS)

    Otis, Laura

    In diesem Jahr, in dem wir Charles Darwins gedenken, möchte ich etwas riskieren und eine Frage erörtern, die für die Literatur ebenso wie für die Biologie zentral ist: Was ist das Leben? Die Antwort auf diese Frage finden wir nicht in der Bibliothek und nicht im Labor, zumindest nicht an diesen erkenntnisproduzierenden Stellen allein. Als Literaturwissenschaftlerin und ehemalige Naturwissenschaftlerin glaube ich, dass wir das Leben nur verstehen werden, wenn wir seinen Wirkungen überall nachforschen, inklusive in der Literatur.

  9. The Deaf Acculturation Scale (DAS): development and validation of a 58-item measure.

    PubMed

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales, and construct validity was established by demonstrating that the DAS could discriminate groups based on parental hearing status, school background, and use of self-labels. Construct validity was further demonstrated through factorial analyses, and findings resulted in a final 58-item measure. Directions for future research are discussed.

  10. Anbindung des SISIS-SunRise-Bibliothekssystems an das zentrale Identitätsmanagement

    NASA Astrophysics Data System (ADS)

    Ebner, Ralf; Pretz, Edwin

    Wir berichten über Konzepte und Implementierungen zur Datenprovisionierung aus den Personenverwaltungssystemen der Technischen Universität München (TUM) über das zentrale Metadirectory am Leibniz-Rechenzentrum (LRZ) in das SISIS-SunRise-Bibliothekssystem der Universitätsbibliothek der TUM (TUB). Es werden drei Implementierungsvarianten diskutiert, angefangen von der Generierung und Übertragung einfacher CSV-Dateien über ein OpenLDAP-basiertes Konzept als Backend für die SISIS-Datenbank bis zur endgültigen Implementierung mit dem OCLC IDM Connector.

  11. Isospora serinuse n. sp. (Apicomplexa: Eimeriidae) from a domestic canary (Serinus canaria forma domestica) (Passeriformes: Fringillidae) in Western Australia.

    PubMed

    Yang, Rongchang; Brice, Belinda; Elliot, Aileen; Ryan, Una

    2015-12-01

    A new species, Isospora serinuse n. sp., (Apicomplexa:Eimeriidae) is described from a single domestic canary (Serinus canaria forma domestica) (subspecies S. c. domestica) in Western Australia. Sporulated oocysts of Isospora serinuse n. sp. are spherical or subspherical, 25.5 (24.4-27.0) × 23.5 (22.0-24.8) μm, with a shape index (length/width) of 1.09; and a smooth bilayered oocyst wall, 1.2 μm thick (outer layer 0.9 μm, inner 0.3 μm). A polar granule is present, but a micropyle and oocyst residuum are absent. The sporocysts are lemon-shaped, 18.9 (17.8-20.2) × 11.8 (10.6-13.0) μm, with a shape index of 1.6. Stieda and substieda bodies are present, the Stieda body being a small crescent shape and the substieda being indistinct. Each sporocyst with four vermiform sporozoites arranged head to tail. A sporocyst residuum is present and composed of numerous granules of different sizes that are scattered among the sporozoites. Morphologically, the oocysts of Isospora serinuse n. sp. were different from those of all known valid Isospora spp. Molecular analysis was conducted at 3 loci: the 18S and 28S ribosomal RNA and two separate regions of subunit I of the mitochondrial cytochrome oxidase (COI) gene (designated COIa and COIb). At the 18S locus, Isospora serinuse n. sp. exhibited 97.5% similarity to Isospora sp. Tokyo from a domestic pigeon (Columba livia domestica) in Japan. At the 28S locus, I. serinuse n. sp. exhibited 94.9% similarity to Isospora anthochaerae n. sp. from a red wattlebird (Anthochaera carunculata) in Australia. At the COIa locus, I. serinuse n. sp. exhibited 95.7% similarity to Isospora sospora sp. ex Apodemus flavicollis from a yellow-necked mouse and Isospora gryphoni from an American goldfinch (Carduelis tristis) respectively. At the COIb locus, I. serinuse n. sp. exhibited 96.7% similarity to an Isospora (iSAT4) from a European pied flycatcher (Ficedula hypoleuca). Based on morphological and molecular data, this isolate is a new

  12. Landsat 8's atmospheric correction in SeaDAS: comparison with AERONET-OC (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Concha, Javier A.

    2016-09-01

    There is a growing interest in high spatial resolution imagery for the retrieval of biogeochemical components over water to study the processes involved in inland and coastal waters as well as in the open ocean. High spatial resolution satellite presents a kind of different problems to the ones for coarse spatial resolution satellites (i.e. MODIS) for deriving ocean color products (i.e. chlorophyll-a or colored dissolved organic matter at a specific wavelength). The SeaDAS package has recently added the capability to handle Landsat 8 data and to produce ocean color standard products, but validation of the atmospheric correction with in situ data is needed. In this work, different schemes for atmospheric correction within SeaDAS are applied. These schemes include the use of the NIR-SWIR 2, SWIR 1-SWIR 2 combinations, with and without spatial averaging to account for the low signal-to-noise ratio (SNR) in the SWIR bands. The products from the atmospheric correction in SeaDAS, i.e. remote-sensing reflectance (Rrs) at four different wavelengths, are compared with in situ data. This is the first attempt to compare in situ Rrs with the output from SeaDAS/l2gen.

  13. PoroTomo Project - Subatask 6.2: Deploy and Operate DAS and DTS arrays

    SciTech Connect

    Dante Fratta

    2016-03-31

    This metadata submission includes the coordinates of the DAS and DTS surface and borehole arrays, the list of file names, and the list of recorded files during testing at the PoroTomo Natural Laboratory at Brady Hot Spring in Nevada. Testing was completed during March 2016.

  14. The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

    ERIC Educational Resources Information Center

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales,…

  15. I/O Parallelization for the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Lucchesi, Rob; Sawyer, W.; Takacs, L. L.; Lyster, P.; Zero, J.

    1998-01-01

    The National Aeronautics and Space Administration (NASA) Data Assimilation Office (DAO) at the Goddard Space Flight Center (GSFC) has developed the GEOS DAS, a data assimilation system that provides production support for NASA missions and will support NASA's Earth Observing System (EOS) in the coming years. The GEOS DAS will be used to provide background fields of meteorological quantities to EOS satellite instrument teams for use in their data algorithms as well as providing assimilated data sets for climate studies on decadal time scales. The DAO has been involved in prototyping parallel implementations of the GEOS DAS for a number of years and is now embarking on an effort to convert the production version from shared-memory parallelism to distributed-memory parallelism using the portable Message-Passing Interface (MPI). The GEOS DAS consists of two main components, an atmospheric General Circulation Model (GCM) and a Physical-space Statistical Analysis System (PSAS). The GCM operates on data that are stored on a regular grid while PSAS works with observational data that are scattered irregularly throughout the atmosphere. As a result, the two components have different data decompositions. The GCM is decomposed horizontally as a checkerboard with all vertical levels of each box existing on the same processing element(PE). The dynamical core of the GCM can also operate on a rotated grid, which requires communication-intensive grid transformations during GCM integration. PSAS groups observations on PEs in a more irregular and dynamic fashion.

  16. The Great War and Remembrance in Jose Leon Machado's "Memoria das Estrelas sem Brilho"

    ERIC Educational Resources Information Center

    Azevedo, Milton M.

    2011-01-01

    This article analyzes Jose Leon Machado's novel, "Memoria das Estrelas sem Brilho," as a multilayered historical novel in which a war story provides a background for comments on aspects of early twentieth-century Portuguese society, such as male bonding, religion, sexual mores, and social stratification. (Contains 11 notes.)

  17. Psychometric properties of the Disability Assessment Schedule (DAS) for behavior problems: an independent investigation.

    PubMed

    Tsakanikos, Elias; Underwood, Lisa; Sturmey, Peter; Bouras, Nick; McCarthy, Jane

    2011-01-01

    The present study employed the Disability Assessment Schedule (DAS) to assess problem behaviors in a large sample of adults with ID (N=568) and evaluate the psychometric properties of this instrument. Although the DAS problem behaviors were found to be internally consistent (Cronbach's α=.87), item analysis revealed one weak item ('Objectional habits') with item-total biserial correlation of only .20. An exploratory factor analysis revealed two main factors. The first factor consisted of items relating to disruptive/distractive problems. The second factor consisted of items relating to antisocial/delinquent problems. Disruptive/distractive problems were specifically associated with low ID level. Antisocial/delinquent behaviors were specifically associated with male gender, schizophrenia, hospital admission and troubles with police. For patients who had both disruptive/distractive problems and antisocial/delinquent behaviors, personality disorders and autism were more frequent, where as anxiety and depression were less frequent. On the basis of the obtained results, two new DAS subscales for assessing challenging behavior were proposed. Both subscales had good levels of internal consistency, as well as face and criterion validity. Overall, the new DAS subscales were shown to have acceptable psychometric properties and have therefore potential for use in both research and clinical practice. Copyright © 2010 Elsevier Ltd. All rights reserved.

  18. The Great War and Remembrance in Jose Leon Machado's "Memoria das Estrelas sem Brilho"

    ERIC Educational Resources Information Center

    Azevedo, Milton M.

    2011-01-01

    This article analyzes Jose Leon Machado's novel, "Memoria das Estrelas sem Brilho," as a multilayered historical novel in which a war story provides a background for comments on aspects of early twentieth-century Portuguese society, such as male bonding, religion, sexual mores, and social stratification. (Contains 11 notes.)

  19. The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

    ERIC Educational Resources Information Center

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales,…

  20. MiDAS: the field guide to the microbes of activated sludge

    PubMed Central

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes—knowledge that will be an invaluable resource for the optimal design and operation of these systems. Database URL: http://www.midasfieldguide.org PMID:26120139

  1. Incorporating Parallel Computing into the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Larson, Jay W.

    1998-01-01

    Atmospheric data assimilation is a method of combining actual observations with model forecasts to produce a more accurate description of the earth system than the observations or forecast alone can provide. The output of data assimilation, sometimes called the analysis, are regular, gridded datasets of observed and unobserved variables. Analysis plays a key role in numerical weather prediction and is becoming increasingly important for climate research. These applications, and the need for timely validation of scientific enhancements to the data assimilation system pose computational demands that are best met by distributed parallel software. The mission of the NASA Data Assimilation Office (DAO) is to provide datasets for climate research and to support NASA satellite and aircraft missions. The system used to create these datasets is the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The core components of the the GEOS DAS are: the GEOS General Circulation Model (GCM), the Physical-space Statistical Analysis System (PSAS), the Observer, the on-line Quality Control (QC) system, the Coupler (which feeds analysis increments back to the GCM), and an I/O package for processing the large amounts of data the system produces (which will be described in another presentation in this session). The discussion will center on the following issues: the computational complexity for the whole GEOS DAS, assessment of the performance of the individual elements of GEOS DAS, and parallelization strategy for some of the components of the system.

  2. A Brief History of the J.P. Das Developmental Disabilities Centre

    ERIC Educational Resources Information Center

    Sobsey, Dick

    2008-01-01

    The J.P. Das Developmental Disabilities Centre celebrated its 40th anniversary on September 1, 2007, followed by The University of Alberta's 100th anniversary in 2008. The year 2008 also brought the appointment of a new Director for the Centre. As the immediate past Director of the Centre, the author recounts some of the history of the J.P. Das…

  3. Abpfiff für das Fußball-Universum

    NASA Astrophysics Data System (ADS)

    Bartelmann, Matthias

    2005-03-01

    Aus Beobachtungen der kosmischen Hintergrundstrahlung lassen sich zwar Rückschlüsse auf die Größe und die Topologie des Universums ziehen. Die Behauptung, aus den Daten des Satelliten WMap würde folgen, dass das Universum endlich groß sei und die Topologie eines Dodekaeders aufweise, wurde jedoch widerlegt.

  4. MiDAS: the field guide to the microbes of activated sludge.

    PubMed

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes--knowledge that will be an invaluable resource for the optimal design and operation of these systems. © The Author(s) 2015. Published by Oxford University Press.

  5. Reisen im freien Fall - Teil 2: Das Zwillingsparadoxon aus dem Blickwinkel der ART

    NASA Astrophysics Data System (ADS)

    Sonne, Bernd; Weiß, Reinhard

    2013-07-01

    Nachdem wir uns mit den Prinzipien der ART und einigen Beispielen vertraut gemacht haben, kommen wir nun zur Berechnung des Zwillingsparadoxons aus Sicht des reisenden Zwillings. Dabei spielt das Äquivalenzprinzip eine große Rolle. Deshalb wird die Bewegungssituation noch einmal erläutert, diesmal aus Sicht von Katrin. Sie befindet sich in ihrem System S'in Ruhe. In ihrem System läuft die Zeit t'ab. Nach dem Start fühlt Katrin jedoch eine Kraft, die sie als Gravitationskraft interpretieren kann. Sie merkt es daran, dass sie in den Sitz gedrückt wird. Nach einiger Zeit werden die Triebwerke abgeschaltet, und das Raumschiff fliegt mit konstanter Geschwindigkeit weiter, Phase 2. Anschließend wird der Schub der Triebwerke solange umgekehrt, bis das Raumschiff irgendwo mit der Geschwindigkeit null am Umkehrpunkt U landet, Phase 3 (Abb. 15.1). Die Erde, auf der sich Michael befindet, bewegt sich mit x'(t') aus Sicht von Katrin im freien Fall von ihr weg, s. das Experiment mit dem steigenden Fahrstuhl in Abschn. 13.2.1.

  6. Biochemical characterization of two cloned resistance determinants encoding a paromomycin acetyltransferase and a paromomycin phosphotransferase from Streptomyces rimosus forma paromomycinus.

    PubMed Central

    Pérez-González, J A; López-Cabrera, M; Pardo, J M; Jiménez, A

    1989-01-01

    The mechanism conferring resistance to paromomycin in Streptomyces rimosus forma paromomycinus, the producing organism, was studied at the level of both protein synthesis and drug-inactivating enzymes. Ribosomes prepared from this organism grown in either production or nonproduction medium were fully sensitive to paromomycin. A paromomycin acetyltransferase and a paromomycin phosphotransferase, both characteristic of the producer, were highly purified from extracts prepared from two Streptomyces lividans transformants harboring the relevant genes inserted in pIJ702-derived plasmids. In vitro, paromomycin was inactivated by either activity. In vivo, however, S. lividans clones containing the gene for either enzyme inserted in the low-copy-number plasmid pIJ41 were resistant to only low levels of paromomycin. In contrast, an S. lividans transformant containing both genes inserted in the same pIJ41-derived plasmid displayed high levels of resistance to paromomycin. These results indicate that both genes are required to determine the high levels of resistance to this drug in the producing organism. Paromomycin is doubly modified by the enzymes. However, whereas acetylparomomycin was a poorer substrate than paromomycin for the phosphotransferase, phosphorylparomomycin was modified more actively than was the intact drug by the acetyltransferase. These findings are discussed in terms of both a permeability barrier to paromomycin and the possible role(s) of the two enzymes in the biosynthetic pathway of this antibiotic. PMID:2536659

  7. Caecal abnormality in a layer hen (Gallus gallus forma domestica) without deficits in digestive performance or egg productivity.

    PubMed

    Courtney Jones, Stephanie K; Munn, Adam J

    2013-01-01

    We report a case of a layer hen (Gallus gallus forma domestica) with deviation in the morphology of the caecum, and unique opportunity to investigate the digestive performance of the animal compared with normal hens. In a study investigating digestive and reproductive performance, an atypical caecal arrangement was found in a hen that was unremarkable in regards to body mass, digestive performance and egg productivity in comparison to other hens fed a similar diet. Examination of the gastrointestinal tract revealed a singular tubular outgrowth from the ileo-caecal junction, rather than the typical paired outgrowths. The single caecal duct bifurcated into two separate blind-ended sacs. Similar caecal deviations have been described in adult and juveniles, but no indications of animal performance were reported in these cases. We conclude that if the presence of an abnormal caecal arrangement reduces digestive abilities they were not obvious, and some compensatory mechanism/s may exist. Alternatively, the abnormal caecal arrangement of our hen might function adequately, such that no compensation in feed intakes or reduced egg productivity was required or observed. © 2012 Japanese Society of Animal Science.

  8. No contact transmission of avian bornavirus in experimentally infected cockatiels (Nymphicus hollandicus) and domestic canaries (Serinus canaria forma domestica).

    PubMed

    Rubbenstroth, Dennis; Brosinski, Katrin; Rinder, Monika; Olbert, Marita; Kaspers, Bernd; Korbel, Rüdiger; Staeheli, Peter

    2014-08-06

    Avian bornaviruses (ABV) are the causative agents of proventricular dilatation disease (PDD), a widely distributed disease of parrots. Distinct ABV lineages were also found in various non-psittacine avian species, such as canaries, but the pathogenic role of ABV in these species is less clear. Despite the wide distribution of ABV in captive parrots and canaries, its mode of transmission is poorly understood: both horizontal transmission via the urofaecal-oral route and vertical transmission are discussed to play a role. In this study we investigated pathology and horizontal transmission of ABV in domestic canaries (Serinus canaria forma domestica) and cockatiels (Nymphicus hollandicus), two natural host species commonly used for experimental ABV infections. ABV inoculation resulted in persistent infection of all inoculated animals from both species. ABV-infected cockatiels exhibited PDD-like symptoms, such as neurologic signs or shedding of undigested seeds. In contrast, infected domestic canaries did not develop clinical disease. Interestingly, we did not detect viral RNA in cloacal swabs and organ samples or ABV-specific antibodies in serum samples of contact-exposed sentinel birds from either species at any time during a four months observation period. Our results strongly indicate that horizontal transmission of ABV by direct contact is inefficient in immunocompetent fully fledged domestic canaries and cockatiels. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Performance of broiler chickens fed diets containing DAS-68416-4 soybean meal.

    PubMed

    Herman, Rod A; Dunville, Christina M; Juberg, Daland R; Fletcher, Dale W; Cromwell, Gary L

    2011-01-01

    Broiler chickens are a fast growing monogastric animal commonly used to evaluate the equivalence between transgenic and non-transgenic grains as part of the human safety assessment process. While commonly viewed like other livestock feeding trials, such studies are performed with transgenic crops with input traits (that are not designed to improve nutrition) to aid regulatory authorities in evaluating safety. Studies of this type are actually more similar to toxicology studies in purpose, with sensitive endpoints like growth used to detect metabolic perturbations. DAS-68416-4 soybean expresses the aryloxyalkanoate dioxygenase-12 (AAD-12) enzyme which inactivates 2,4-diclorophenoxyacetic acid (2,4-D) and provides DAS-68416-4 soybeans tolerance to this herbicide. DAS-68416-4 also expresses the phosphinothricin acetyltransferase (PAT) enzyme from Streptomyces viridochromogenes which confers tolerance to glufosinate-ammonium herbicides. A 6-week broiler study was conducted with diets containing toasted DAS-68416-4 soybean meal (40, 36, and 32% in starter, grower and finisher diets, respectively) to evaluate nutritional wholesomeness and safety compared with conventional comparators. Toasting soybean meal is required to inactivate endogenous antinutrients making soybean suitable for consumption by monogastric animals like broiler chickens. Toasting was found to denature both the AAD-12 and PAT proteins rendering them non-detectable by enzyme linked immunosorbent assays. Broiler growth and performance parameters were measured over a 6-week period of exposure to diets containing different sources of toasted soybean meal, and results indicate that DAS-68416-4 soybean is nutritionally equivalent to non-transgenic soybean.

  10. Detecting changes following the provision of assistive devices: utility of the WHO-DAS II.

    PubMed

    Raggi, Alberto; Albanesi, Francesca; Gatti, Valeria; Andrich, Renzo; Leonardi, Matilde

    2010-12-01

    The World Health Organization Disability Assessment Schedule II (WHO-DAS II) is a non-disease-specific International Classification of Functioning, Disability, and Health-based disability assessment instrument developed to measure activity limitations and restrictions to participation. The aim of this pilot study is to evaluate WHO-DAS II responsiveness in detecting short-time changes following the provision of an Assistive Technology,which is important to define its utility in performing daily activities. Adult inpatients with a diagnosis of Disease of the Nervous System (included in Chapter VI of the ICD-10),who were prescribed an Assistive Technology to be used in the household settings, were enrolled. The WHO-DAS II was administered in individual interview at baseline and at a 2 months follow-up: in this period patients were transitioning from the hospital to home. Changes in disability profiles were detected by calculating the effect size (ES) for each WHO-DAS II domain. Ten patients with different neurological diseases were enrolled. Few longitudinal changes in disability level are reported: mild improvement is observed in the household activities (ES0.28), whereas mild worsening is reported in self-care and participation in society domains (ES – 0.27 and – 0.26,respectively). Our study shows that the WHO-DAS II is responsive in detecting domain-specific changes over a short-term period and provides preliminary encouraging evidence for the utility of its utilization in clinical settings.However, changes in setting between baseline and follow up could have an impact on the findings and interpretation of this study.

  11. A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

    PubMed Central

    2012-01-01

    Background The herbal preparation DAS-77, used for the treatment of various ailments in Nigeria, contains the milled bark of Mangifera indica L. and root of Carica papaya L. Toxicological assessment of the preparation was carried out in this study. Methods In the acute toxicity study, DAS-77 was administered to mice p.o. up to 20 g/kg in divided doses and i.p. at 250–3000 mg/kg. Mortality within 24 h was recorded. In the chronic toxicity study, rats were treated p.o. for 90 days at doses of 80, 400 (therapeutic dose, TD) and 2000 mg/kg. By 90 days, animals were sacrificed and blood samples collected for hematological and biochemical analysis. Organs were harvested for weight determination, antioxidants and histopathological assessments. Results DAS-77 did not produce any lethality administered p.o. up to 20 g/kg in divided doses but the i.p. LD50 was 1122.0 mg/kg. At TD, DAS-77 produced significant (p < 0.05) reductions in body weight, food intake and K+, and increases in ovary weight, neutrophils and HDL, which were reversible. Histopathological presentations were generally normal. Effects at the other doses were comparable to those at TD except for reversible increases in antioxidants in the liver, kidney and testes, and sperm abnormality, and reductions in liver enzymes, sperm motility and count. Conclusions Findings in this study revealed that DAS-77 is relatively safe with the potential for enhancing in vivo antioxidant activity. However, possibly reversible side-effects include electrolyte imbalance and sterility in males. PMID:22892317

  12. DAS steered therapy in clinical practice; cross-sectional results from the METEOR database.

    PubMed

    Gvozdenović, Emilia; Wolterbeek, Ron; van der Heijde, Désirée; Huizinga, Tom; Allaart, Cornelia; Landewé, Robert

    2016-01-16

    Little is known on how well targeted treatment, for instance targeting towards low DAS, is implemented in clinical practice. Our aim was to evaluate treatment adjustments in response to DAS in RA patients in clinical practice. We used data from one referral centre, multiple rheumatologists, from the METEOR database. Generalized Estimating Equations (GEE) were used to assess whether in case of non-low disease activity (DAS > 2.4) treatment intensifications in DMARD therapy occurred ((change or increase in dose or number of DMARDs, including synthetic (s)DMARDs, biologic (b)DMARDs and corticosteroids compared to the visit before)). Determinants of not intensifying the treatment when DAS > 2.4 were investigated using GEE. Five thousand one hundred fifty-seven registered visits of 1202 patients were available for the analyses. A DAS > 2.4 was weakly (OR: 1.19; 95% CI 1.07-1.33) associated with a treatment intensification. In 69% (n = 3577) of the visits patients were in low disease activity. In 66% (n = 1028) of the visits with DAS > 2.4 treatment was not intensified. These patients had a higher tender joint count and received more often methotrexate plus a bDMARD, or csDMARD monotherapy, as compared to patients that received treatment intensification. In the majority of visits in the METEOR database patients were already in a state of low disease activity, reflecting appropriate treatment intensity. When DAS was greater than 2.4, treatment was often not intensified due to high tender joint count or specific treatment combinations. This data suggest that while aiming for low DAS, physicians per patient weigh whether all DAS elements indicate disease activity or will respond to DMARD adjustment or not, and make treatment decisions accordingly.

  13. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... catch limits (ACL), annual catch targets (ACT), DAS allocations, and individual fishing quotas (IFQ... limits (ACL), annual catch targets (ACT), DAS allocations, and individual fishing quotas (IFQ). (a... limited access scallop fishery shall be allocated 94.5 percent of the ACL specified in paragraph (a)(1)...

  14. A Letter to the Parent(s) of a Child with Developmental Apraxia of Speech. Part IV: Treatment of DAS.

    ERIC Educational Resources Information Center

    Hall, Penelope K.

    2000-01-01

    One of a series of letters to parents of children with developmental apraxia of speech (DAS), this letter discusses the treatment of DAS including linguistic approaches, motor-programming approaches, a combination of linguistic and motor-programming approaches, and treatment approaches that include specific sensory and gestural cueing techniques.…

  15. A Letter to the Parent(s) of a Child with Developmental Apraxia of Speech. Part IV: Treatment of DAS.

    ERIC Educational Resources Information Center

    Hall, Penelope K.

    2000-01-01

    One of a series of letters to parents of children with developmental apraxia of speech (DAS), this letter discusses the treatment of DAS including linguistic approaches, motor-programming approaches, a combination of linguistic and motor-programming approaches, and treatment approaches that include specific sensory and gestural cueing techniques.…

  16. dnaA suppressor (dasF) mutants of Escherichia coli are stable DNA replication (sdrA/rnh) mutants.

    PubMed

    Torrey, T A; Atlung, T; Kogoma, T

    1984-01-01

    The possible allelic relationship between dasF (dnaA suppressor) and sdrA/rnh (stable DNA replication/RNase H) mutations was examined. dasF mutations could not only suppress various dnaA(ts) mutations, but also the insertional inactivation of the dnaA gene or deletion of the oriC sequence, as could sdrA mutations. dasF mutants were found to exhibit the stable DNA replication phenotype, and the sensitivity to rich media, of sdrA mutants. The dasF and sdrA mutations were mapped very closely between metD and proA on the E. coli genetic map. The mutations were recessive to the wild-type allele for all the above phenotypes. It was concluded that dasF is allelic to sdrA/mh.

  17. Annotation and visualization of endogenous retroviral sequences using the Distributed Annotation System (DAS) and eBioX

    PubMed Central

    Martínez Barrio, Álvaro; Lagercrantz, Erik; Sperber, Göran O; Blomberg, Jonas; Bongcam-Rudloff, Erik

    2009-01-01

    Background The Distributed Annotation System (DAS) is a widely used network protocol for sharing biological information. The distributed aspects of the protocol enable the use of various reference and annotation servers for connecting biological sequence data to pertinent annotations in order to depict an integrated view of the data for the final user. Results An annotation server has been devised to provide information about the endogenous retroviruses detected and annotated by a specialized in silico tool called RetroTector. We describe the procedure to implement the DAS 1.5 protocol commands necessary for constructing the DAS annotation server. We use our server to exemplify those steps. Data distribution is kept separated from visualization which is carried out by eBioX, an easy to use open source program incorporating multiple bioinformatics utilities. Some well characterized endogenous retroviruses are shown in two different DAS clients. A rapid analysis of areas free from retroviral insertions could be facilitated by our annotations. Conclusion The DAS protocol has shown to be advantageous in the distribution of endogenous retrovirus data. The distributed nature of the protocol is also found to aid in combining annotation and visualization along a genome in order to enhance the understanding of ERV contribution to its evolution. Reference and annotation servers are conjointly used by eBioX to provide visualization of ERV annotations as well as other data sources. Our DAS data source can be found in the central public DAS service repository, , or at . PMID:19534743

  18. Clinical potential of DAS181 for treatment of parainfluenza-3 infections in transplant recipients.

    PubMed

    Guzmán-Suarez, B B; Buckley, M W; Gilmore, E T; Vocca, E; Moss, R; Marty, F M; Sanders, R; Baden, L R; Wurtman, D; Issa, N C; Fang, F; Koo, S

    2012-08-01

    Parainfluenza virus (PIV) infections can cause serious respiratory infections and death in immunocompromised patients. No antiviral agents have proven efficacy against PIV, and therapy generally consists of supportive care. DAS181, a novel sialidase fusion protein that temporarily disables airway epithelial PIV receptors by enzymatic removal of sialic acid moieties, has been shown to inhibit infection with PIV strains in vitro and in an animal model. We describe here the clinical course of 2 immunocompromised patients with PIV-3 infection, one with a history of lung transplantation and the other neutropenic after autologous hematopoietic stem cell transplantation for multiple myeloma. Both patients had substantial clinical improvement in respiratory and systemic symptoms after a 5-day DAS181 treatment course, although the clinical improvement in the autologous stem cell transplantation patient also paralleled neutrophil engraftment.

  19. Smart Home, Smart Grid, Smart Meter - digitale Konzepte und das Recht an Daten

    NASA Astrophysics Data System (ADS)

    Spiecker genannt Döhmann, Indra

    Modernes Energiemanagement setzt auf ein intelligent gesteuertes Energieinformationsnetz, das Smart Grid. In diesem ist der Smart Meter, die intelligente Messstelle beim Nutzer, ein zentrales Instrument für den wechselseitigen Austausch von Informationen. Allerdings werfen die über diverse Gesetze forcierten Informationsströme erhebliche datenschutzrechtliche Fragen auf. Der Beitrag stellt zentrale datenschutzrechtliche Leitlinien und Probleme vor und behandelt auch offene Fragestellungen.

  20. DAS Boot!

    ERIC Educational Resources Information Center

    Chretien, Wendy

    2007-01-01

    The residential services group is lobbying to dump its aging hard-wired phone system because students don't use it. The town and campus public safety officials are demanding that their portable two-way radios operate well not only outdoors, but within campus buildings. Students are now expecting text messaging and WiFi service to work everywhere…

  1. DAS Boot!

    ERIC Educational Resources Information Center

    Chretien, Wendy

    2007-01-01

    The residential services group is lobbying to dump its aging hard-wired phone system because students don't use it. The town and campus public safety officials are demanding that their portable two-way radios operate well not only outdoors, but within campus buildings. Students are now expecting text messaging and WiFi service to work everywhere…

  2. Inhibition of cyclooxygenase-2 by diallyl sulfides (DAS) in HEK 293T cells.

    PubMed

    Elango, Erode M; Asita, Hag; Nidhi, Gunapalan; Seema, Parvathy; Banerji, Asoke; Kuriakose, Moni A

    2004-01-01

    Cyclooxygenase (COX) is involved in modulating inflammatory response through the synthesis of prostaglandins. The inducible isoform of the enzyme, COX-2, is overexpressed in some malignant and premalignant lesions. Several preclinical and clinical studies have reported COX-2 inhibition as an effective strategy for chemoprevention. Nonsteroidal anitinflammatory drugs (NASIDs) such as celecoxib, are the most widely investigated COX-2 inhibitors. The oil-soluble diallyl sulfides (DAS) include monosulfides (DAMS), disulfides (DADS) and trisulfides (DATS). They were found to be effective against canine and human tumors, the mechanism of which remains unresolved. We attempted a comparative evaluation of the antiproliferative effect of DAS in HEK 293T cells. The cells were treated with increasing concentrations of DAMS, DADS and DATS. There were significant differences between the IC50 values of DAMS, DADS and DATS. RT-PCR was performed and the expression of COX-2 was compared with that of b actin. DATS inhibited COX-2 gene expression significantly stronger than DAMS and DADS. The data are suggestive of antineoplastic effect of DAS, mediated by controlling COX-2 expression.

  3. pH modulates arsenic toxicity in Bacillus licheniformis DAS-2.

    PubMed

    Tripti, K; Shardendu

    2016-08-01

    The toxic characteristics of arsenic species, As(V) and As(III) result in ecological risks. Arsenic tolerant bacterium was isolated and identified as the Bacillus licheniformis DAS-2 through 16SrDNA sequencing. B. licheniformis DAS-2 was efficient to tolerate and remove both the As(V)[MIC 8mM] and As(III)[MIC 6mM] from the growth medium. The potential for the removal/uptake of arsenic from the 3, 5 and 7mM As(V) enriched growth media was 100%, 60% and 35% respectively and from the 1, 3 and 5mM As(III) enrichment it was 100%, 99% and 58% respectively at neutral pH. 80% of uptake As(V) was reduced to As(III) in 3mM As(V) enrichment which was gradually decreased to only 17% at 7mM As(V) enrichment at neutral pH. The arsenic toxicity in B. licheniformis DAS-2 was found modulated by pH and was examined through alteration in growth, uptake/removal, reduction and measurement of chemical toxicity.

  4. Assimilation of SBUV Version 8 Radiances into the GEOS Ozone DAS

    NASA Technical Reports Server (NTRS)

    Mueller, Martin D.; Stajner, Ivanka; Bhartia, Pawan K.

    2004-01-01

    In operational weather forecasting, the assimilation of brightness temperatures from satellite sounders, instead of assimilation of 1D-retrievals has become increasingly common practice over the last two decades. Compared to these systems, assimilation of trace gases is still at a relatively early stage of development, and efforts to directly assimilate radiances instead of retrieved products have just begun a few years ago, partially because it requires much more computation power due to the employment of a radiative transport forward model (FM). This paper will focus on a method to assimilate SBUV/2 radiances (albedos) into the Global Earth Observation System Ozone Data Assimilation Scheme (GEOS-03DAS). While SBUV-type instruments cannot compete with newer sensors in terms of spectral and horizontal resolution, they feature a continuous data record back to 1978, which makes them very valuable for trend studies. Assimilation can help spreading their ground coverage over the whole globe, as has been previously demonstrated with the GEOS-03DAS using SBUV Version 6 ozone profiles. Now, the DAS has been updated to use the newly released SBUV Version 8 data. We will compare pre]lmlnarv results of SBUV radiance assimilation with the assimilation of retrieved ozone profiles, discuss methods to deal with the increased computational load, and try to assess the error characteristics and future potential of the new approach.

  5. Performance of broiler chickens fed event DAS-40278-9 maize containing the aryloxyalkanoate dioxygenase-1 protein.

    PubMed

    Herman, Rod A; Dunville, Christina M; Juberg, Daland R; Fletcher, Dale W; Cromwell, Gary L

    2011-08-01

    Event DAS-40278-9 maize grain (containing the aryloxyalkanoate dioxygenase-1 protein), a non-transgenic near-isogenic maize grain, or one of three commercial maize grains were included in the diets of broiler chickens for six weeks. Growth, feed conversion, and carcass measurements indicated no significant difference between the groups fed the diets containing the DAS-40278-9 maize grain and those fed diets containing the matched control grain. The absence of adverse effects in this study supports the dietary safety of the AAD-1 protein expressed in event DAS-40278-9 maize. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Infection of Brachypodium distachyon by formae speciales of Puccinia graminis: early infection events and host-pathogen incompatibility.

    PubMed

    Figueroa, Melania; Alderman, Stephen; Garvin, David F; Pfender, William F

    2013-01-01

    Puccinia graminis causes stem rust, a serious disease of cereals and forage grasses. Important formae speciales of P. graminis and their typical hosts are P. graminis f. sp. tritici (Pg-tr) in wheat and barley, P. graminis f. sp. lolii (Pg-lo) in perennial ryegrass and tall fescue, and P. graminis f. sp. phlei-pratensis (Pg-pp) in timothy grass. Brachypodium distachyon is an emerging genetic model to study fungal disease resistance in cereals and temperate grasses. We characterized the P. graminis-Brachypodium pathosystem to evaluate its potential for investigating incompatibility and non-host resistance to P. graminis. Inoculation of eight Brachypodium inbred lines with Pg-tr, Pg-lo or Pg-pp resulted in sporulating lesions later accompanied by necrosis. Histological analysis of early infection events in one Brachypodium inbred line (Bd1-1) indicated that Pg-lo and Pg-pp were markedly more efficient than Pg-tr at establishing a biotrophic interaction. Formation of appressoria was completed (60-70% of germinated spores) by 12 h post-inoculation (hpi) under dark and wet conditions, and after 4 h of subsequent light exposure fungal penetration structures (penetration peg, substomatal vesicle and primary infection hyphae) had developed. Brachypodium Bd1-1 exhibited pre-haustorial resistance to Pg-tr, i.e. infection usually stopped at appressorial formation. By 68 hpi, only 0.3% and 0.7% of the Pg-tr urediniospores developed haustoria and colonies, respectively. In contrast, development of advanced infection structures by Pg-lo and Pg-pp was significantly more common; however, Brachypodium displayed post-haustorial resistance to these isolates. By 68 hpi the percentage of urediniospores that only develop a haustorium mother cell or haustorium in Pg-lo and Pg-pp reached 8% and 5%, respectively. The formation of colonies reached 14% and 13%, respectively. We conclude that Brachypodium is an apt grass model to study the molecular and genetic components of incompatiblity

  7. I/O Parallelization for the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Lucchesi, R.; Sawyer, W.; Takacs, L. L.; Lyster, P.; Zero, J.

    1999-01-01

    The National Aeronautics and Space Administration (NASA) Data Assimilation Office (DAO) at the Goddard Space Flight Center (GSFC) has developed the GEOS DAS, a data assimilation system that provides production support for NASA missions and will support NASA's Earth Observing System (EOS) in the coming years. The DAO's support of the EOS project along with the requirement of producing long-term reanalysis datasets with an unvarying system levy a large I/O burden on the future system. The DAO has been involved in prototyping parallel implementations of the GEOS DAS for a number of years and is now converting the production version from shared-memory parallelism to distributed-memory parallelism using the portable Message-Passing Interface (MPI). If the MPI-based GEOS DAS is to meet these production requirements, we must make I/O from the parallel system efficient. We have designed a scheme that allows efficient I/O processing while retaining portability, reducing the need for post-processing, and producing data formats that are required by our users, both internal and external. The first phase of the GEOS DAS Parallel I/O System (GPIOS) will expand upon the common method of gathering global data to a Single PE for output. Instead of using a PE also tasked with primary computation, a number of PEs will be dedicated to I/O and its related tasks. This allows the data transformations and formatting required prior to output to take place asynchronously with respect to the GEOS DAS assimilation cycle, improving performance and generating output data sets in a format convenient for our users. I/O PEs can be added as needed to handle larger data volumes or to meet user file specifications. We will show I/O performance results from a prototype MPI GCM integrated with GPIOS. Phase two of GPIOS development will examine ways of integrating new software technologies to further improve performance and build scalability into the system. The maturing of MPI-IO implementations and

  8. I/O Parallelization for the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Lucchesi, R.; Sawyer, W.; Takacs, L. L.; Lyster, P.; Zero, J.

    1999-01-01

    The National Aeronautics and Space Administration (NASA) Data Assimilation Office (DAO) at the Goddard Space Flight Center (GSFC) has developed the GEOS DAS, a data assimilation system that provides production support for NASA missions and will support NASA's Earth Observing System (EOS) in the coming years. The DAO's support of the EOS project along with the requirement of producing long-term reanalysis datasets with an unvarying system levy a large I/O burden on the future system. The DAO has been involved in prototyping parallel implementations of the GEOS DAS for a number of years and is now converting the production version from shared-memory parallelism to distributed-memory parallelism using the portable Message-Passing Interface (MPI). If the MPI-based GEOS DAS is to meet these production requirements, we must make I/O from the parallel system efficient. We have designed a scheme that allows efficient I/O processing while retaining portability, reducing the need for post-processing, and producing data formats that are required by our users, both internal and external. The first phase of the GEOS DAS Parallel I/O System (GPIOS) will expand upon the common method of gathering global data to a Single PE for output. Instead of using a PE also tasked with primary computation, a number of PEs will be dedicated to I/O and its related tasks. This allows the data transformations and formatting required prior to output to take place asynchronously with respect to the GEOS DAS assimilation cycle, improving performance and generating output data sets in a format convenient for our users. I/O PEs can be added as needed to handle larger data volumes or to meet user file specifications. We will show I/O performance results from a prototype MPI GCM integrated with GPIOS. Phase two of GPIOS development will examine ways of integrating new software technologies to further improve performance and build scalability into the system. The maturing of MPI-IO implementations and

  9. How to assess appearance distress and motivation in plastic surgery candidates: Italian validation of Derriford Appearance Scale 59 (DAS 59).

    PubMed

    Cogliandro, A; Persichetti, P; Ghilardi, G; Moss, T P; Barone, M; Piccinocchi, G; Ricci, G; Vitali, M; Giuliani, A; Tambone, V

    2016-09-01

    The Derriford Appearance Scale (DAS) 59 was specifically designed to measure psychosocial adjustment in patients with appearance problems. Previous studies using the DAS59 have proven it to be a reliable method of assessing the appearance-related quality of life after plastic surgery procedures. The aim of this study was to develop a valid and reliable Italian version of the DAS59. The first Italian translation of this questionnaire was conducted according to the DAS59 protocol that was designed by the original authors of the questionnaire. Eight hundred patients participated in this study and filled out three questionnaires (DAS59, General Health Questionnaire (GHQ)12 and Beck's Depression Inventory (BDI)-II). There were 400 adult patients with a history of previous plastic surgeries and 400 adult patients without any personal history of previous plastic surgery procedures. A total of 50 patients were selected randomly for test-retest analysis. The overall internal consistency was excellent (α = 0.95) and equal to that of the original article that first described the scale. There was a good correlation between all the items. Domains demonstrated good internal consistency (Cronbach's alpha) and correlation within themselves. The construct validity of the Italian DAS59 was assessed under convergent validity that confirmed the correlation with scales related to other psychological conditions. GHQ12 showed relevant correlation with DAS59, while BDI-II did not. A valid and reliable Italian DAS59 version was developed that can be used for research and clinical assessment of patients with appearance problems and concerns, especially before and after plastic surgery procedures.

  10. Annotation and visualization of endogenous retroviral sequences using the Distributed Annotation System (DAS) and eBioX.

    PubMed

    Barrio, Alvaro Martínez; Lagercrantz, Erik; Sperber, Göran O; Blomberg, Jonas; Bongcam-Rudloff, Erik

    2009-06-16

    The Distributed Annotation System (DAS) is a widely used network protocol for sharing biological information. The distributed aspects of the protocol enable the use of various reference and annotation servers for connecting biological sequence data to pertinent annotations in order to depict an integrated view of the data for the final user. An annotation server has been devised to provide information about the endogenous retroviruses detected and annotated by a specialized in silico tool called RetroTector. We describe the procedure to implement the DAS 1.5 protocol commands necessary for constructing the DAS annotation server. We use our server to exemplify those steps. Data distribution is kept separated from visualization which is carried out by eBioX, an easy to use open source program incorporating multiple bioinformatics utilities. Some well characterized endogenous retroviruses are shown in two different DAS clients. A rapid analysis of areas free from retroviral insertions could be facilitated by our annotations. The DAS protocol has shown to be advantageous in the distribution of endogenous retrovirus data. The distributed nature of the protocol is also found to aid in combining annotation and visualization along a genome in order to enhance the understanding of ERV contribution to its evolution. Reference and annotation servers are conjointly used by eBioX to provide visualization of ERV annotations as well as other data sources. Our DAS data source can be found in the central public DAS service repository, http://www.dasregistry.org, or at http://loka.bmc.uu.se/das/sources.

  11. Validation of Land-Surface Mosaic Heterogeneity in the GEOS DAS

    NASA Technical Reports Server (NTRS)

    Bosilovich, Michael G.; Molod, Andrea; Houser, Paul R.; Schubert, Siegfried

    1999-01-01

    The Mosaic Land-surface Model (LSM) has been included into the current GEOS Data Assimilation System (DAS). The LSM uses a more advanced representation of physical processes than previous versions of the GEOS DAS, including the representation of sub-grid heterogeneity of the land-surface through the Mosaic approach. As a first approximation, Mosaic assumes that all similar surface types within a grid-cell can be lumped together as a single'tile'. Within one GCM grid-cell, there might be 1 - 5 different tiles or surface types. All tiles are subjected to the grid-scale forcing (radiation, air temperature and specific humidity, and precipitation), and the sub-grid variability is a function of the tile characteristics. In this paper, we validate the LSM sub-grid scale variability (tiles) using a variety of surface observing stations from the Southern Great Plains (SGP) site of the Atmospheric Radiation Measurement (ARM) Program. One of the primary goals of SGP ARM is to study the variability of atmospheric radiation within a G,CM grid-cell. Enough surface data has been collected by ARM to extend this goal to sub-grid variability of the land-surface energy and water budgets. The time period of this study is the Summer of 1998 (June I - September 1). The ARM site data consists of surface meteorology, energy flux (eddy correlation and bowen ratio), soil water observations spread over an area similar to the size of a G-CM grid-cell. Various ARM stations are described as wheat and alfalfa crops, pasture and range land. The LSM tiles considered at the grid-space (2 x 2.5) nearest the ARM site include, grassland, deciduous forests, bare soil and dwarf trees. Surface energy and water balances for each tile type are compared with observations. Furthermore, we will discuss the land-surface sub-grid variability of both the ARM observations and the DAS.

  12. Validation of Land-Surface Mosaic Heterogeneity in the GEOS DAS

    NASA Technical Reports Server (NTRS)

    Bosilovich, Michael G.; Molod, Andrea; Houser, Paul R.; Schubert, Siegfried

    1999-01-01

    The Mosaic Land-surface Model (LSM) has been included into the current GEOS Data Assimilation System (DAS). The LSM uses a more advanced representation of physical processes than previous versions of the GEOS DAS, including the representation of sub-grid heterogeneity of the land-surface through the Mosaic approach. As a first approximation, Mosaic assumes that all similar surface types within a grid-cell can be lumped together as a single'tile'. Within one GCM grid-cell, there might be 1 - 5 different tiles or surface types. All tiles are subjected to the grid-scale forcing (radiation, air temperature and specific humidity, and precipitation), and the sub-grid variability is a function of the tile characteristics. In this paper, we validate the LSM sub-grid scale variability (tiles) using a variety of surface observing stations from the Southern Great Plains (SGP) site of the Atmospheric Radiation Measurement (ARM) Program. One of the primary goals of SGP ARM is to study the variability of atmospheric radiation within a G,CM grid-cell. Enough surface data has been collected by ARM to extend this goal to sub-grid variability of the land-surface energy and water budgets. The time period of this study is the Summer of 1998 (June I - September 1). The ARM site data consists of surface meteorology, energy flux (eddy correlation and bowen ratio), soil water observations spread over an area similar to the size of a G-CM grid-cell. Various ARM stations are described as wheat and alfalfa crops, pasture and range land. The LSM tiles considered at the grid-space (2 x 2.5) nearest the ARM site include, grassland, deciduous forests, bare soil and dwarf trees. Surface energy and water balances for each tile type are compared with observations. Furthermore, we will discuss the land-surface sub-grid variability of both the ARM observations and the DAS.

  13. High resolution DAS via sinusoidal frequency scan OFDR (SFS-OFDR).

    PubMed

    Leviatan, Eyal; Eyal, Avishay

    2015-12-28

    There are many advantages to using direct frequency modulation for OFDR based DAS. However, achieving sufficiently linear scan via direct frequency modulation is challenging and poses limits on the scan parameters. A novel method for analyzing sinusoidal frequency modulated light is presented and demonstrated for both static and dynamic sensing. SFS-OFDR projects the measured signal onto appropriate sinusoidal phase terms to obtain spatial information. Thus, by using SFS-OFDR on sinusoidal modulated light it is possible to make use of the many advantages offered by direct frequency modulation without the limitations posed by the linearity requirement.

  14. [An example of partnership cooperation. Cantonal League against Tuberculosis and Lung Diseases/Association "Das Band"].

    PubMed

    Michaelis, E

    1984-01-01

    Together with the Cantonal League against Tuberculosis and Lung Diseases of Zurich, the Association "Das Band" has organized a first course for parents of children with asthma. The course is a component of the associations new "Prophylaxis Program for Children with Asthma and Their Parents". By exchanging ideas, the parents should become able to reflect their situation, characterized by excessive protectionism, aggressiveness, and guiltiness, and they also should learn to accept the disease as a part of their daily life. The first course, which meanwhile is followed by a second one, provided a first base for the solution of the many problems.

  15. GenExp: An Interactive Web-Based Genomic DAS Client with Client-Side Data Rendering

    PubMed Central

    Gel Moreno, Bernat; Messeguer Peypoch, Xavier

    2011-01-01

    Background The Distributed Annotation System (DAS) offers a standard protocol for sharing and integrating annotations on biological sequences. There are more than 1000 DAS sources available and the number is steadily increasing. Clients are an essential part of the DAS system and integrate data from several independent sources in order to create a useful representation to the user. While web-based DAS clients exist, most of them do not have direct interaction capabilities such as dragging and zooming with the mouse. Results Here we present GenExp, a web based and fully interactive visual DAS client. GenExp is a genome oriented DAS client capable of creating informative representations of genomic data zooming out from base level to complete chromosomes. It proposes a novel approach to genomic data rendering and uses the latest HTML5 web technologies to create the data representation inside the client browser. Thanks to client-side rendering most position changes do not need a network request to the server and so responses to zooming and panning are almost immediate. In GenExp it is possible to explore the genome intuitively moving it with the mouse just like geographical map applications. Additionally, in GenExp it is possible to have more than one data viewer at the same time and to save the current state of the application to revisit it later on. Conclusions GenExp is a new interactive web-based client for DAS and addresses some of the short-comings of the existing clients. It uses client-side data rendering techniques resulting in easier genome browsing and exploration. GenExp is open source under the GPL license and it is freely available at http://gralggen.lsi.upc.edu/recerca/genexp. PMID:21750706

  16. Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation.

    PubMed

    Kondo, Ayano; Nonaka, Aya; Shimamura, Teppei; Yamamoto, Shogo; Yoshida, Tetsuo; Kodama, Tatsuhiko; Aburatani, Hiroyuki; Osawa, Tsuyoshi

    2017-09-15

    Long noncoding RNAs play a pivotal role in tumor progression, but their role in cancer cells in the nutrient-starved tumor microenvironment remains unknown. Here, we show that a nutrient starvation-responsive long noncoding RNA, JHDM1D antisense 1 (JHDM1D-AS1), promotes tumorigenesis by regulating angiogenesis in response to nutrient starvation. Expression of JHDM1D-AS1 was increased in cancer cells. In addition, expression of JHDM1D-AS1 was increased in clinical tumor samples compared to that in normal tissue. Stable expression of JHDM1D-AS1 in human pancreatic cancer (PANC-1 and AsPC-1) cells promoted cell growth in vitro Remarkably, these JHDM1D-AS1-expressing cells showed a significant increase in tumor growth in vivo that was associated with increased formation of CD31(+) blood vessels and elevated infiltration of CD11b(+) macrophage lineage cells into tumor tissues. Genome-wide analysis of tumor xenografts revealed that expression of genes for tumor-derived angiogenic factors such as hHGF and hFGF1 concomitant with host-derived inflammation-responsive genes such as mMmp3, mMmp9, mS100a8, and mS100a9 was increased in tumor xenografts of JHDM1D-AS1-expressing pancreatic cancer cells, leading to a poor prognosis. Our results provide evidence that increased JHDM1D-AS1 expression under nutrient starvation accelerates tumor growth by upregulating angiogenesis, thus laying the foundation for improved therapeutic strategies. Copyright © 2017 Kondo et al.

  17. Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation

    PubMed Central

    Kondo, Ayano; Nonaka, Aya; Shimamura, Teppei; Yamamoto, Shogo; Yoshida, Tetsuo; Kodama, Tatsuhiko; Aburatani, Hiroyuki

    2017-01-01

    ABSTRACT Long noncoding RNAs play a pivotal role in tumor progression, but their role in cancer cells in the nutrient-starved tumor microenvironment remains unknown. Here, we show that a nutrient starvation-responsive long noncoding RNA, JHDM1D antisense 1 (JHDM1D-AS1), promotes tumorigenesis by regulating angiogenesis in response to nutrient starvation. Expression of JHDM1D-AS1 was increased in cancer cells. In addition, expression of JHDM1D-AS1 was increased in clinical tumor samples compared to that in normal tissue. Stable expression of JHDM1D-AS1 in human pancreatic cancer (PANC-1 and AsPC-1) cells promoted cell growth in vitro. Remarkably, these JHDM1D-AS1-expressing cells showed a significant increase in tumor growth in vivo that was associated with increased formation of CD31+ blood vessels and elevated infiltration of CD11b+ macrophage lineage cells into tumor tissues. Genome-wide analysis of tumor xenografts revealed that expression of genes for tumor-derived angiogenic factors such as hHGF and hFGF1 concomitant with host-derived inflammation-responsive genes such as mMmp3, mMmp9, mS100a8, and mS100a9 was increased in tumor xenografts of JHDM1D-AS1-expressing pancreatic cancer cells, leading to a poor prognosis. Our results provide evidence that increased JHDM1D-AS1 expression under nutrient starvation accelerates tumor growth by upregulating angiogenesis, thus laying the foundation for improved therapeutic strategies. PMID:28652266

  18. Ocean Color Measurements from Landsat-8 OLI using SeaDAS

    NASA Technical Reports Server (NTRS)

    Franz, Bryan Alden; Bailey, Sean W.; Kuring, Norman; Werdell, P. Jeremy

    2014-01-01

    The Operational Land Imager (OLI) is a multi-spectral radiometer hosted on the recently launched Landsat-8 satellite. OLI includes a suite of relatively narrow spectral bands at 30-meter spatial resolution in the visible to shortwave infrared that make it a potential tool for ocean color radiometry: measurement of the reflected spectral radiance upwelling from beneath the ocean surface that carries information on the biogeochemical constituents of the upper ocean euphotic zone. To evaluate the potential of OLI to measure ocean color, processing support was implemented in SeaDAS, which is an open-source software package distributed by NASA for processing, analysis, and display of ocean remote sensing measurements from a variety of satellite-based multi-spectral radiometers. Here we describe the implementation of OLI processing capabilities within SeaDAS, including support for various methods of atmospheric correction to remove the effects of atmospheric scattering and absorption and retrieve the spectral remote-sensing reflectance (Rrs; sr exp 1). The quality of the retrieved Rrs imagery will be assessed, as will the derived water column constituents such as the concentration of the phytoplankton pigment chlorophyll a.

  19. The development of Music in Dementia Assessment Scales (MiDAS).

    PubMed

    McDermott, Orii; Orrell, Martin; Ridder, Hanne Mette

    2015-07-03

    There is a need to develop an outcome measure specific to music therapy in dementia that reflects a holistic picture of the therapy process and outcome. This study aimed to develop a clinically relevant and scientifically robust music therapy outcome measure incorporating the values and views of people with dementia. Focus groups and interviews were conducted to obtain qualitative data on what music meant to people with dementia and the observed effects of music. Expert and peer consultations were conducted at each stage of the measure development to maximise its content validity. The new measure was field-tested by clinicians in a care home. Feedback from the clinicians and music therapy experts were incorporated during the review and refinement process of the measure. A review of the existing literature, the experiential results and the consensus process enabled the development of the new outcome measure "Music in Dementia Assessment Scales (MiDAS)". Analysis of the qualitative data identified five key areas of the impact of music on people with dementia and they were transformed as the five Visual Analogue Scale (VAS) items: levels of Interest, Response, Initiation, Involvement and Enjoyment. MiDAS comprises the five VAS items and a supplementary checklist of notable positive and negative reactions from the individual. This study demonstrates that it is possible to design and develop an easy to apply and rigorous quantitative outcome measure which has a high level of clinical relevance for people with dementia, care home staff and music therapists.

  20. Trends and variability of climate and river flow in the region of Costa das Baleias, Brazil.

    PubMed

    Genz, F; Tanajura, C A S

    2013-01-01

    There is an ongoing effort by the scientific community to regionalize climate studies to support local development plans. The area of interest is the Costa das Baleias on the east coast of northeast Brazil. It is located in a transition region of precipitation trends, and so assessing the local signal and magnitude is necessary. A series of annual anomalies of surface air temperature, precipitation and river discharge were analyzed from 1946 to 2010. The modified Mann-Kendall test was applied to detect trends. Temperature anomalies showed a consistent positive trend since 1950. Precipitation anomalies tended to decrease, though not significantly. River discharge rates showed a consistent positive trend. However, from the 1980s onwards, both the precipitation and the river discharge anomalies had the same decreasing tendency. The precipitation and discharge behavior are likely due to the combined effect of human interventions in the river basins including local, synoptic and global climate effects. The inter-annual variability was characterized by spectral analysis. Cycles were identified for the precipitation and the river discharge with periods of 2-3 years, 3-4 years, 7-8 years and 11-12 years. The decadal frequency is consistent with the South Atlantic and El Niño indices. This work strongly indicates that climate is changing in Costa das Baleias and further work is needed to investigate the mechanisms that link local to large-scale variability.

  1. The development of Music in Dementia Assessment Scales (MiDAS)

    PubMed Central

    McDermott, Orii; Orrell, Martin; Ridder, Hanne Mette

    2015-01-01

    There is a need to develop an outcome measure specific to music therapy in dementia that reflects a holistic picture of the therapy process and outcome. This study aimed to develop a clinically relevant and scientifically robust music therapy outcome measure incorporating the values and views of people with dementia. Focus groups and interviews were conducted to obtain qualitative data on what music meant to people with dementia and the observed effects of music. Expert and peer consultations were conducted at each stage of the measure development to maximise its content validity. The new measure was field-tested by clinicians in a care home. Feedback from the clinicians and music therapy experts were incorporated during the review and refinement process of the measure. A review of the existing literature, the experiential results and the consensus process enabled the development of the new outcome measure “Music in Dementia Assessment Scales (MiDAS)”. Analysis of the qualitative data identified five key areas of the impact of music on people with dementia and they were transformed as the five Visual Analogue Scale (VAS) items: levels of Interest, Response, Initiation, Involvement and Enjoyment. MiDAS comprises the five VAS items and a supplementary checklist of notable positive and negative reactions from the individual. This study demonstrates that it is possible to design and develop an easy to apply and rigorous quantitative outcome measure which has a high level of clinical relevance for people with dementia, care home staff and music therapists. PMID:26246670

  2. Genome-wide analysis of in vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets.

    PubMed

    Świątek-Połatyńska, Magdalena A; Bucca, Giselda; Laing, Emma; Gubbens, Jacob; Titgemeyer, Fritz; Smith, Colin P; Rigali, Sébastien; van Wezel, Gilles P

    2015-01-01

    Streptomycetes produce a wealth of natural products, including over half of all known antibiotics. It was previously demonstrated that N-acetylglucosamine and secondary metabolism are closely entwined in streptomycetes. Here we show that DNA recognition by the N-acetylglucosamine-responsive regulator DasR is growth-phase dependent, and that DasR can bind to sites in the S. coelicolor genome that have no obvious resemblance to previously identified DasR-responsive elements. Thus, the regulon of DasR extends well beyond what was previously predicted and includes a large number of genes with functions far removed from N-acetylglucosamine metabolism, such as genes for small RNAs and DNA transposases. Conversely, the DasR regulon during vegetative growth largely correlates to the presence of canonical DasR-responsive elements. The changes in DasR binding in vivo following N-acetylglucosamine induction were studied in detail and a possible molecular mechanism by which the influence of DasR is extended is discussed. Discussion of DasR binding was further informed by a parallel transcriptome analysis of the respective cultures. Evidence is provided that DasR binds directly to the promoters of all genes encoding pathway-specific regulators of antibiotic production in S. coelicolor, thereby providing an exquisitely simple link between nutritional control and secondary metabolism.

  3. Comparative genomics and prediction of conditionally dispensable sequences in legume-infecting Fusarium oxysporum formae speciales facilitates identification of candidate effectors.

    PubMed

    Williams, Angela H; Sharma, Mamta; Thatcher, Louise F; Azam, Sarwar; Hane, James K; Sperschneider, Jana; Kidd, Brendan N; Anderson, Jonathan P; Ghosh, Raju; Garg, Gagan; Lichtenzveig, Judith; Kistler, H Corby; Shea, Terrance; Young, Sarah; Buck, Sally-Anne G; Kamphuis, Lars G; Saxena, Rachit; Pande, Suresh; Ma, Li-Jun; Varshney, Rajeev K; Singh, Karam B

    2016-03-05

    Soil-borne fungi of the Fusarium oxysporum species complex cause devastating wilt disease on many crops including legumes that supply human dietary protein needs across many parts of the globe. We present and compare draft genome assemblies for three legume-infecting formae speciales (ff. spp.): F. oxysporum f. sp. ciceris (Foc-38-1) and f. sp. pisi (Fop-37622), significant pathogens of chickpea and pea respectively, the world's second and third most important grain legumes, and lastly f. sp. medicaginis (Fom-5190a) for which we developed a model legume pathosystem utilising Medicago truncatula. Focusing on the identification of pathogenicity gene content, we leveraged the reference genomes of Fusarium pathogens F. oxysporum f. sp. lycopersici (tomato-infecting) and F. solani (pea-infecting) and their well-characterised core and dispensable chromosomes to predict genomic organisation in the newly sequenced legume-infecting isolates. Dispensable chromosomes are not essential for growth and in Fusarium species are known to be enriched in host-specificity and pathogenicity-associated genes. Comparative genomics of the publicly available Fusarium species revealed differential patterns of sequence conservation across F. oxysporum formae speciales, with legume-pathogenic formae speciales not exhibiting greater sequence conservation between them relative to non-legume-infecting formae speciales, possibly indicating the lack of a common ancestral source for legume pathogenicity. Combining predicted dispensable gene content with in planta expression in the model legume-infecting isolate, we identified small conserved regions and candidate effectors, four of which shared greatest similarity to proteins from another legume-infecting ff. spp. We demonstrate that distinction of core and potential dispensable genomic regions of novel F. oxysporum genomes is an effective tool to facilitate effector discovery and the identification of gene content possibly linked to host

  4. A causa das estações do ano: modelos mentais

    NASA Astrophysics Data System (ADS)

    de Campos, J. A. S.; de Araujo, J. F. S.

    2003-08-01

    A década de 70 do século passado foi marcada pelo estudo das concepções alternativas que os alunos trazem para a sala de aula. A identificação destas concepções foi o ponto de partida para promover a mudança conceitual, onde as pré-concepções seriam trocadas pelas concepções científicas. Na década seguinte, surgiram muitas propostas de estratégias educacionais para facilitar esta troca, na sua maioria baseadas na idéia do conflito cognitivo, proposta por Piaget. Entretanto, os resultados pouco animadores conduziram à percepção de que a mudança conceitual é um processo mais complexo. Pelas idéias da Ciência Cognitiva, a mudança conceitual é uma mudança progressiva dos modelos mentais que o aluno tem sobre o mundo físico, através de enriquecimento e revisão. A causa das Estações do Ano é um tópico sobre o qual a maioria dos estudantes apresenta concepções alternativas. Os autores fizeram um levantamento sobre as pré-concepções encontradas em trabalhos sobre o tema (16 referências), procurando encontrar elementos comuns que indicassem a presença de modelos mentais específicos. As pré-concepções encontradas na literatura foram obtidas usando-se diversas metodologias (desde entrevistas clínicas até questionários de múltipla escolha) e envolvendo alunos e professores de diferentes regiões geográficas. A partir de uma análise aprofundada de cada trabalho, e utilizando-se a técnica das Redes Sistêmicas, chegou-se a conclusão que as diversas pré-concepções identificadas (em torno de 50), poderiam ser representadas por 6 modelos mentais, onde a explicação da causa das estações do ano tem um mecanismo causal responsável. Os mecanismos causais identificados foram: a dependência da distância, a dependência da orientação, a dependência conjunta da distância e orientação, a dependência da obstrução, a dependência da velocidade e a dependência da inclinação dos raios solares. Foram ainda identificadas

  5. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene

    PubMed Central

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J.; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R.; Kim, Jeong Beom

    2016-01-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC. PMID:26846167

  6. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene

    NASA Astrophysics Data System (ADS)

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J.; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R.; Kim, Jeong Beom

    2016-02-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC.

  7. Measuring Primary Teachers' Attitudes Toward Teaching Science: Development of the Dimensions of Attitude Toward Science (DAS) Instrument

    NASA Astrophysics Data System (ADS)

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-03-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the professionalization of these teachers in the field of primary science education. With the development of this instrument, we sought to fulfill the need for a statistically and theoretically valid and reliable instrument to measure pre-service and in-service teachers' attitudes. The DAS Instrument is based on a comprehensive theoretical framework for attitude toward (teaching) science. After pilot testing, the DAS was revised and subsequently validated using a large group of respondents (pre-service and in-service primary teachers) (N = 556). The theoretical underpinning of the DAS combined with the statistical data indicate that the DAS possesses good construct validity and that it proves to be a promising instrument that can be utilized for research purposes, and also as a teacher training and coaching tool. This instrument can therefore make a valuable contribution to progress within the field of science education.

  8. A distância e o conteúdo estelar da região HII gigante G333.1-0.4 - vínculos para a taxa de formação estelar da galáxia

    NASA Astrophysics Data System (ADS)

    Figuerêdo, E.; Damineli, A.; Blum, R.; Conti, P.

    2003-08-01

    Neste trabalho apresentamos imagens de alta resolução angular da região HII gigante G333.1-0.4 obtidas através dos filtros J, H e K no telescópio de 4-m do CTIO. Este trabalho faz parte de um estudo de regiões HII gigantes no infravermelho próximo que tem por objetivo estudar a natureza da formação de estrelas massivas e traçar a estrutura espiral de nossa galáxia. Nossa determinação da distância é baseada no método da paralaxe espectroscópica de estrelas OB localizadas na seqüência principal de idade zero (ZAMS) do Diagrama HR. No caso de G333.1-0.4, a magnitude aparente das estrelas localizadas na ZAMS indica que a distância não pode ser maior do que o limite inferior determinado por técnica rádio (2,8 kpc). Resultados semelhantes foram encontrados para regiões estudadas anteriormente, reforçando a idéia de que a taxa de formação estelar na Via Láctea é menor do que o determinado a partir de dados rádio. Nossos resultados mais recentes sobre o conteúdo estelar de G333.1-0.4 revelaram vários objetos que possuem cores bastante avermelhadas (H-K > 2,0). Nós identificamos estes objetos usando os diagramas cor-cor e cor-magnitude dos aglomerados. Estes objetos apresentam um forte excesso em emissão na banda K e possivelmente se tratam de estrelas do tipo OB envolvidas por um disco/envelope circumestelar espesso. O estudo da função de massa inical desta região, em conjunto com resultados de nossos trabalhos anteriores, aponta para uma IMF independente da posição galática. A contagem de estrelas nos fornece um valor para o número de fótons no contínuo de Lyman que corrobora com a afirmação de que G333.1-0.4 se encontra mais próxima da menor distância determinada por rádio.

  9. Subchronic feeding study with genetically modified stacked trait lepidopteran and coleopteran resistant (DAS-Ø15Ø7-1xDAS-59122-7) maize grain in Sprague-Dawley rats.

    PubMed

    Appenzeller, Laura M; Malley, Linda; Mackenzie, Susan A; Hoban, Denise; Delaney, Bryan

    2009-07-01

    DAS-Ø15Ø7-1xDAS-59122-7 (1507x59122) is a genetically modified (GM) maize hybrid that was produced by crossing of two GM maize inbreds; DAS-Ø15Ø7-1 and DAS-59122-7. This hybrid cross expresses four transgenic proteins: Cry1F and PAT (from DAS-Ø15Ø7-1) and Cry34Ab1/Cry35Ab1 and PAT (from DAS-59122-7) that confer resistance to lepidopteran and coleopteran pests and tolerance to the herbicidal active ingredient glufosinate-ammonium. The current subchronic feeding study was conducted in Sprague-Dawley rats to evaluate the potential health effects of long-term consumption of a rodent diet containing 1507x59122 maize grain compared with a diet containing maize grain from its near-isogenic control (091). Diets formulated with three unrelated non-GM commercial hybrids (3573, 35P12, 36G12) were also included for within study reference data. All diets contained 34% (w/wt) maize grain and were prepared according to the specifications of PMI((R)) Nutrition International, LLC Certified Rodent LabDiet((R)) 5002 (PMI((R)) 5002). Diets were fed ad libitum to rats for at least 92days. OECD 408 response variables from rats fed the 1507x59122 diet were compared with those from rats fed the 091 control diet. No toxicologically significant differences were observed in nutritional performance variables, clinical and neurobehavioral signs, ophthalmology, clinical pathology (hematology, clinical chemistry, coagulation, and urinalysis), organ weights, and gross and microscopic pathology between rats in the 091 and 1507x59122 treatment groups. The results from this study demonstrate that 1507x59122 maize grain is as safe and nutritious as non-GM maize grain and support the concept that crossing of two safe GM maize events results in production of a safe stacked GM event.

  10. DasPy – Open Source Multivariate Land Data Assimilation Framework with High Performance Computing

    NASA Astrophysics Data System (ADS)

    Han, Xujun; Li, Xin; Montzka, Carsten; Kollet, Stefan; Vereecken, Harry; Hendricks Franssen, Harrie-Jan

    2015-04-01

    Data assimilation has become a popular method to integrate observations from multiple sources with land surface models to improve predictions of the water and energy cycles of the soil-vegetation-atmosphere continuum. In recent years, several land data assimilation systems have been developed in different research agencies. Because of the software availability or adaptability, these systems are not easy to apply for the purpose of multivariate land data assimilation research. Multivariate data assimilation refers to the simultaneous assimilation of observation data for multiple model state variables into a simulation model. Our main motivation was to develop an open source multivariate land data assimilation framework (DasPy) which is implemented using the Python script language mixed with C++ and Fortran language. This system has been evaluated in several soil moisture, L-band brightness temperature and land surface temperature assimilation studies. The implementation allows also parameter estimation (soil properties and/or leaf area index) on the basis of the joint state and parameter estimation approach. LETKF (Local Ensemble Transform Kalman Filter) is implemented as the main data assimilation algorithm, and uncertainties in the data assimilation can be represented by perturbed atmospheric forcings, perturbed soil and vegetation properties and model initial conditions. The CLM4.5 (Community Land Model) was integrated as the model operator. The CMEM (Community Microwave Emission Modelling Platform), COSMIC (COsmic-ray Soil Moisture Interaction Code) and the two source formulation were integrated as observation operators for assimilation of L-band passive microwave, cosmic-ray soil moisture probe and land surface temperature measurements, respectively. DasPy is parallelized using the hybrid MPI (Message Passing Interface) and OpenMP (Open Multi-Processing) techniques. All the input and output data flow is organized efficiently using the commonly used NetCDF file

  11. Integriertes Informationsmanagement an der Westfälischen Wilhelms-Universität Münster - Das Projekt MIRO

    NASA Astrophysics Data System (ADS)

    Vogl, Raimund; Gildhorn, Antje; Labitzke, Jörg; Wibberg, Michael

    An der Westfälischen Wilhelms-Universität Münster (WWU) wurde bereits 1996 ein tragfähiges, kooperativ ausgerichtetes System der IT-Governance im Zusammenspiel zentraler und dezentraler IT-Leistungserbringer etabliert. Um den Anforderungen an ein integriertes Informationsmanagement im Überlappungsfeld von Information, Kommunikation und Medien (IKM) durch das Zusammenspiel der zentralen Einrichtungen Universitätsverwaltung (UniV), Universitäts- und Landesbibliothek (ULB) und Zentrum für Informationsverarbeitung (ZIV) gerecht zu werden, wurde 2003 der IKM-Service institutionalisiert. In diesem Rahmen wurde das Projekt Münster Information System for Research and Organization (MIRO) entwickelt, das als Leistungszentrum für Forschungsinformation von der DFG gefördert wird. Die bisherigen Projekterfahrungen, erreichten Ziele und verbleibenden Aufgaben werden dargestellt. Im Projektverlauf haben sich insbesondere die etablierten IT-Governance und Versorgungs-Strukturen sowie die Unterstützung der Hochschulleitung als essentielle Erfolgskriterien erwiesen.

  12. Viscous dissipation effects on unsteady mixed convective stagnation point flow using Tiwari-Das nanofluid model

    NASA Astrophysics Data System (ADS)

    Mabood, F.; Ibrahim, S. M.; Kumar, P. V.; Khan, W. A.

    A mathematical model has been developed using Tiwari-Das model to study the MHD stagnation-point flow and heat transfer characteristics of an electrically conducting nanofluid over a vertical permeable shrinking/stretching sheet in the presence of viscous dissipation. Formulated partial differential equations are converted into a set of ordinary differential equations using suitable similarity transformation. Runge-Kutta-Fehlberg method with shooting technique is applied to solve the resulting coupled ordinary differential equations. The profiles for velocity, temperature, skin friction coefficient and local Nusselt number for various parameters are displayed through graphs and tabular forms. In this problem, we considered two types of nanoparticles, namely, copper (Cu) and Alumina (Al2O3) with water as base fluid.

  13. Event DAS-444Ø6-6 soybean grown in Brazil is compositionally equivalent to non-transgenic soybean.

    PubMed

    Fast, Brandon J; Galan, Maria P; Schafer, Ariane C

    2016-04-02

    Soybean event DAS-444Ø6-6 is tolerant to the herbicides 2,4-D, glyphosate, and glufosinate. An investigation of potential unintended adverse compositional changes in a genetically modified crop is required to meet government regulatory requirements in various geographies. A study to meet these requirements in Brazil was completed demonstrating compositional equivalency between DAS-444Ø6-6 and non-transgenic soybean. This study supplements the extensive literature supporting transgenesis as less disruptive of crop composition compared with traditional breeding methods.

  14. Event DAS-444Ø6-6 soybean grown in Brazil is compositionally equivalent to non-transgenic soybean

    PubMed Central

    Fast, Brandon J.; Galan, Maria P.; Schafer, Ariane C.

    2016-01-01

    ABSTRACT Soybean event DAS-444Ø6-6 is tolerant to the herbicides 2,4-D, glyphosate, and glufosinate. An investigation of potential unintended adverse compositional changes in a genetically modified crop is required to meet government regulatory requirements in various geographies. A study to meet these requirements in Brazil was completed demonstrating compositional equivalency between DAS-444Ø6-6 and non-transgenic soybean. This study supplements the extensive literature supporting transgenesis as less disruptive of crop composition compared with traditional breeding methods. PMID:27248569

  15. Sobre o uso das séries de Puiseux em mecanica celeste

    NASA Astrophysics Data System (ADS)

    Miloni, O. I.

    2003-08-01

    Neste trabalho é apresentada uma demonstração do uso dos diferentes desenvolvimentos em séries para as equações de perturbação em Mecânica Celeste no marco Hamiltoniano. Em trabalhos clássicos como os de Poincaré (Poincaré, 1893) por exemplo, já esta planteado o uso de potências não inteiras no pequeno parâmetro, o que evidencia a não analiticidade das funções quando uma ressonância ocorre. Nestes trabalhos os desenvolvimentos são na raíz quadrada da massa de Júpiter (o pequeno parâmetro). Mais recentemente (Ferraz-Mello, 1985) outros tipos de desenvolvimentos foram aplicados modificando substancialmente as ordens de grandeza e a velocidade de convergência das séries. Com esta abordagem, os desenvolvimentos foram expressados em termos da raíz cúbica do pequeno parâmetro. Neste trabalho apresentamos um enfoque geral, onde os diferentes tipos de desenvolvimentos em séries de Puiseux (Valiron, 1950) são obtidos a partir da aplicação de Teorema de Preparação de Weierstrass (Goursat, 1916) considerando a equação de Hamilton-Jacobi como uma equação algébrica. Os resultados são aplicados ao problema restrito dos três corpos em ressonância de primeira ordem e, dependendo da grandeza da excentricidade do asteróide em relação à de Júpiter, obtemos os diferentes desenvolvimentos, em raíz quadrada ou raíz cúbica da massa de Júpiter.

  16. O Universo das Sociedades Numa Perspectiva Relativa: Exercícios de Etnoastronomia

    NASA Astrophysics Data System (ADS)

    Fares, Érika Akel; Pessoa Martins, Karla; Maciel Araujo, Lidiane; Sauma Filho, Michel

    2004-12-01

    This work developed at the Planetarium of Pará employing workshops designed for visitor schools (public, private, specials groups), promotes the popularization of the Ethnoastronomy with the aim of diffusing values based on a cultural diversity tolerance and the need of harmonic interplay between people and environment. Using stories and debates, the relationship between humans and the Cosmos is traced from antiquity until today, with the help of slides as a didactic resource. Thus, many conceptions about the origin of the Universe are shown; as well as some constellations created along the History, ending with the present scientific manner of know and explain the World. We then demonstrate the links between space, time and culture with the Cosmos vision. The need to think the World within a plural context to create respect for other different persons is emphasized. Este trabalho, desenvolvido no Planetário do Pará através de oficinas com escolas visitantes (públicas, privadas e grupos especiais), promove a popularização da Etnoastronomia, com o objetivo de difundir valores pautados na tolerância à diversidade cultural e na necessidade da convivência harmônica entre o ser humano e o meio ambiente. Através da contação de histórias e promoção de debate, é tratada a relação dos humanos com o céu desde a antiguidade até os dias atuais, tendo como apoio didático o uso de slides. Assim, são mostradas diversas concepções de origem do Universo; algumas constelações criadas no decorrer da História; e a atual forma científica de conhecer e explicar o mundo. Demonstrando-se, então, a interligação entre espaço, tempo e cultura com a visão do Cosmo. Enfatiza-se a necessidade de se pensar o mundo numa perspectiva relativa ou plural, de forma a propiciar o respeito ao ser diferente.

  17. Cometa Hyakutake (C/1996 B2): análise do gás e características físicas das partículas de poeira

    NASA Astrophysics Data System (ADS)

    Sanzovo, G. C.; de Almeida, A. A.; Boczko, R.

    2003-08-01

    A completa caracterização e compreensão do núcleo de um cometa novo é de fundamental importância para a elucidação dos processos físicos e químicos atuantes na época da formação do Sistema Solar. O Cometa Hyakutake, conjuntamente com o Cometa Hale-Bopp representam os objetos mais brilhantes que visitaram o Sistema Solar Interno nos últimos 20 anos. Neste Trabalho, nós aplicamos o Método Semi-Empírico das Magnitudes Visuais (MSEMV) à aproximadamente 4000 dados observacionais que correlacionam a magnitude visual absoluta com a distância heliocêntrica para o Cometa Hyakutake nas fases pré- e pós-periélicas. Como produto da aplicação desse método, conseguimos caracterizar dimensionalmente seu núcleo e área ativa efetiva. As taxas de produção dos radicais CN, C2 e C3, obtidos a partir de dados disponíveis na literatura, revelam que, além de muito brilhante, o Hyakutake é um cometa "normal" no sentido de Cochran (1986). Desse modo, deduzimos as taxas de perdas de água (em moléculas/s) a partir da análise de sua magnitude visual aparente, e as convertemos em taxas de perdas de gás (em g/s), despreendido pelo nucleo cometário. Com o auxílio do modelo fotométrico clássico da poeira, realizamos uma análise sistemática e uniforme dessa componente cometária, a partir dos fluxos observacionais no contínuo, para os comprimentos de onda 365,0 e 484,5 nm, assumindo que esses fluxos são o resultado da radiação solar espalhada por grãos de partículas micrométricos presentes na coma. Com isso, pudemos obter as taxas de produção (em g/s), cores (relativas à cor neutra solar), e as dimensões efetivas médias das partículas de poeira, bem como as razões poeira-gás.

  18. Chlorobium limicola forma thiosulfatophilum: Biocatalyst in the Production of Sulfur and Organic Carbon from a Gas Stream Containing H2S and CO2

    PubMed Central

    Cork, Douglas J.; Garunas, Ruta; Sajjad, Ashfaq

    1983-01-01

    Chlorobium limicola forma thiosulfatophilum (ATCC 17092) was grown in a 1-liter continuously stirred tank reactor (800-ml liquid volume) at pH 6.8, 30°C, saturated light intensity, and a gas flow rate of 23.6 ml/min from a gas cylinder blend consisting of 3.9 mol% H2S, 9.2 mol% CO2, 86.4 mol% N2, and 0.5 mol% H2. This is the first demonstration of photoautotrophic growth of a Chlorobium sp. on a continuous inorganic gas feed. A significant potential exists for applying this photoautotrophic process to desulfurization and CO2 fixation of gases containing acidic components (H2S and CO2). PMID:16346255

  19. Chlorobium limicola forma thiosulfatophilum: biocatalyst in the production of sulfur and organic carbon from a gas stream containing H/sub 2/O and CO/sub 2/

    SciTech Connect

    Cork, D.J.; Garunas, R.; Sajjad, A.

    1983-03-01

    Chlorobium limicola forma thiosulfatophilum (ATCC 17092) was grown in a 1-liter continuously stirred tank reactor (800-ml liquid volume) at pH 6.8, 30/sup 0/C, saturated light intensity, and gas flow rate of 23.6 ml/min from a gas cylinder blend consisting of 3.9 mol% H/sub 2/S, 9.2 mol% CO/sub 2/, 86.4 mol% N/sub 2/, and 0.5 mol% H/sub 2/. This is the first demonstration of photoautotrophic growth of a Chlorobium sp. on a continuous inorganic gas feed. A significant potential exists for applying this photoautotrophic process to desulfurization and CO/sub 2/ fixation of gases containing acidic components (H/sub 2/S and CO/sub 2/).

  20. Membrane-associated c-type cytochromes from the green sulfur bacterium Chlorobium limicola forma thiosulfatophilum: purification and characterization of cytochrome c553.

    PubMed

    Albouy, D; Sturgis, J N; Feiler, U; Nitschke, W; Robert, B

    1997-02-18

    Tetraheme cytochromes involved in photosynthetic electron transport have previously been described associated with the reaction centers of purple photosynthetic bacteria; however, similar heme proteins have not until now been characterized in the phylogenetically distinct green sulfur bacteria. In this paper we describe the first isolation and characterization of a multitheme, membrane-associated cytochrome from a green sulfur bacterium, Chlorobium limicola forma thiosulfatophilum. We show that this cytochrome contains a single polypeptide of 32 kDa apparent molecular mass on SDS-PAGE and has a characteristic broad alpha-band absorption at 553 nm. By both low-temperature absorption and electron paramagnetic resonance spectroscopy, we demonstrate that there are at least four distinct heme groups.

  1. Test Review: Naglieri, J. A., Das, J. P., & Goldstein, S. (2014). Cognitive Assessment System-Second Edition (2nd Ed.)

    ERIC Educational Resources Information Center

    McGill, Ryan J.

    2015-01-01

    The Cognitive Assessment System-Second Edition (CAS2) is an individually administered measure of cognitive ability designed for children and adolescents ages 5 through 18 years. The measure, authored by Jack A. Naglieri, J. P. Das, and Sam Goldstein, was published by Pro-Ed in 2014 and is the first revision of the Cognitive Assessment System (CAS;…

  2. Latent Factor Structure of the Das-Naglieri Cognitive Assessment System: A Confirmatory Factor Analysis in a Chinese Setting

    ERIC Educational Resources Information Center

    Deng, Ci-ping; Liu, Ming; Wei, Wei; Chan, Raymond C. K.; Das, J. P.

    2011-01-01

    This study aims to measure the psychometric properties of the Das-Naglieri Cognitive Assessment System (D-N CAS) and to determine its clinical utility in a Chinese context. Confirmatory factor analysis (CFA) was conducted to examine the construct validity of the Chinese version of the D-N CAS among a group of 567, normally developed children.…

  3. Processing data for a spatial watershed model to evaluate hydrological responses of the Ribeirão das Posses, Brazil

    USDA-ARS?s Scientific Manuscript database

    Southeastern Brazil has experienced drought conditions that have impacted the conservation of watersheds and the management of water quality and quantity for agricultural and urban demands. The Ribeirão das Posses watershed is being monitored as a headwater of the Jaguarí River, which is one of the ...

  4. Concurrent Validity of the WISC-IV and DAS-II in Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Kuriakose, Sarah

    2014-01-01

    Cognitive assessments are used for a variety of research and clinical purposes in children with autism spectrum disorder (ASD). This study establishes concurrent validity of the Wechsler Intelligence Scales for Children-fourth edition (WISC-IV) and Differential Ability Scales-second edition (DAS-II) in a sample of children with ASD with a broad…

  5. OntoDas – a tool for facilitating the construction of complex queries to the Gene Ontology

    PubMed Central

    O'Neill, Kieran; Garcia, Alexander; Schwegmann, Anita; Jimenez, Rafael C; Jacobson, Dan; Hermjakob, Henning

    2008-01-01

    Background Ontologies such as the Gene Ontology can enable the construction of complex queries over biological information in a conceptual way, however existing systems to do this are too technical. Within the biological domain there is an increasing need for software that facilitates the flexible retrieval of information. OntoDas aims to fulfil this need by allowing the definition of queries by selecting valid ontology terms. Results OntoDas is a web-based tool that uses information visualisation techniques to provide an intuitive, interactive environment for constructing ontology-based queries against the Gene Ontology Database. Both a comprehensive use case and the interface itself were designed in a participatory manner by working with biologists to ensure that the interface matches the way biologists work. OntoDas was further tested with a separate group of biologists and refined based on their suggestions. Conclusion OntoDas provides a visual and intuitive means for constructing complex queries against the Gene Ontology. It was designed with the participation of biologists and compares favourably with similar tools. It is available at PMID:18925933

  6. Measuring Primary Teachers' Attitudes toward Teaching Science: Development of the Dimensions of Attitude toward Science (DAS) Instrument

    ERIC Educational Resources Information Center

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-01-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the…

  7. Test Review: Naglieri, J. A., Das, J. P., & Goldstein, S. (2014). Cognitive Assessment System-Second Edition (2nd Ed.)

    ERIC Educational Resources Information Center

    McGill, Ryan J.

    2015-01-01

    The Cognitive Assessment System-Second Edition (CAS2) is an individually administered measure of cognitive ability designed for children and adolescents ages 5 through 18 years. The measure, authored by Jack A. Naglieri, J. P. Das, and Sam Goldstein, was published by Pro-Ed in 2014 and is the first revision of the Cognitive Assessment System (CAS;…

  8. Concurrent Validity of the WISC-IV and DAS-II in Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Kuriakose, Sarah

    2014-01-01

    Cognitive assessments are used for a variety of research and clinical purposes in children with autism spectrum disorder (ASD). This study establishes concurrent validity of the Wechsler Intelligence Scales for Children-fourth edition (WISC-IV) and Differential Ability Scales-second edition (DAS-II) in a sample of children with ASD with a broad…

  9. Measuring Primary Teachers' Attitudes toward Teaching Science: Development of the Dimensions of Attitude toward Science (DAS) Instrument

    ERIC Educational Resources Information Center

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-01-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the…

  10. Expression of Das-1, Ki67 and sulfuric proteins in gastric cardia adenocarcinoma and intestinal metaplasia lesions

    PubMed Central

    FENG, XIAO-SHAN; WANG, YU-FENG; HAO, SHU-GUANG; RU, YI; GAO, SHE-GAN; WANG, LI-DONG

    2013-01-01

    The aim of this study was to characterize histo-chemical patterns and Das-1 and Ki67 protein expression in gastric cardia adenocarcinoma (GCA) and intestinal metaplasia (IM) lesions adjacent to GCA. Histochemical techniques, including Alcian blue/periodic acid-Schiff (AB/PAS), high iron diamine/Alcian blue (HID/AB) and avidin-biotin-peroxidase complex (ABC) immunohistochemistry were applied to GCA and IM samples from patients (n=200) in Linzhou, Henan, China, a high incidence area for GCA and esophageal squamous cell carcinoma (SCC). The detection rate of IM lesions in resected tissues adjacent to GCA was 32.5% (65/200). GCA and IM lesions presented a high frequency of Das-1 and Ki67-positive staining with statistical significance (P<0.01). The expression of sulfuric proteins did not show co-expression with Das-1 and Ki67 in GCA and surrounding IM lesions (P>0.05) from the same GCA patient. The high frequency of co-expression of Das-1 and Ki67 in GCA and adjacent IM lesions indicates that IM adjacent to GCA may undergo similar molecular changes to GCA, which may be one of the mechanisms for malignant transformation of IM in the population studied. PMID:23837030

  11. Planning Ability across Ranges of Intellectual Ability: An Examination of the Luria-Das Information-Processing Model.

    ERIC Educational Resources Information Center

    McCallum, R. Steve; And Others

    1988-01-01

    Based on Luria-Das information processing theory, hypothesized that 26 educable mentally retarded children would score significantly less well on relatively pure measures of planning ability than would 13 younger average ability students after students were matched on cognitive processing ability. Hypothesis was not supported by study. (Author/NB)

  12. Latent Factor Structure of the Das-Naglieri Cognitive Assessment System: A Confirmatory Factor Analysis in a Chinese Setting

    ERIC Educational Resources Information Center

    Deng, Ci-ping; Liu, Ming; Wei, Wei; Chan, Raymond C. K.; Das, J. P.

    2011-01-01

    This study aims to measure the psychometric properties of the Das-Naglieri Cognitive Assessment System (D-N CAS) and to determine its clinical utility in a Chinese context. Confirmatory factor analysis (CFA) was conducted to examine the construct validity of the Chinese version of the D-N CAS among a group of 567, normally developed children.…

  13. Impaired Left Ventricular Diastolic Functions and Thickened Epicardial Adipose Tissue in Rheumatoid Arthritis Patients is Correlated with DAS-28 Score

    PubMed Central

    Alpaydın, Sertac; Buyukterzi, Zafer; Akkurt, Halil Ekrem; Yılmaz, Halim

    2017-01-01

    Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that is known to be associated with high cardiovascular (CV) morbidity and mortality. In this study, we aimed to demonstrate whether RA disease activity reflected with disease activity score-28 (DAS-28) had an impact on left ventricular diastolic functions and epicardial adipose tissue (EAT) thickness in RA patients with no traditional CV risk factors. Methods In this retrospective study, 41 patients newly diagnosed with RA were included. In addition to medical history, detailed physical examination findings and laboratory tests, left ventricular systolic and diastolic functions, chamber dimensions, and EAT thickness were evaluated with transthoracic echocardiography in the study population. Results This study included 41 subjects with a median age of 45 years (38.00-55.50), of which 29.27% were male. In the binomial logistic regression analysis, DAS-28 score was found to be an independent associate of diastolic dysfunction, Additionally, DAS-28 was found to be independently associated with EAT thickness. Conclusions Patients with high DAS-28 score should be evaluated thoroughly for CV disease, and patients should undergo advanced diagnostic studies as required and receive appropriate treatment. PMID:28344422

  14. Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study.

    PubMed

    Lee, Yvonne C; Cui, Jing; Lu, Bing; Frits, Michelle L; Iannaccone, Christine K; Shadick, Nancy A; Weinblatt, Michael E; Solomon, Daniel H

    2011-06-08

    Disease remission has become a feasible goal for most rheumatoid arthritis (RA) patients; however, patient-reported symptoms, such as pain, may persist despite remission. We assessed the prevalence of pain in RA patients in remission according to the Disease Activity Score (DAS28-CRP4) and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria. Data were analyzed from RA patients in the Brigham Rheumatoid Arthritis Sequential Study with data at baseline and 1 year. DAS28 remission was defined as DAS28-CRP4 <2.6. The ACR/EULAR remission criteria included (a) one or more swollen joints, (b) one or more tender joints, (c) C-reactive protein ≤1 mg/dl, and (d) patient global assessment score ≤1. Pain severity was measured by using the pain score from the Multi-Dimensional Health Assessment Questionnaire (MDHAQ). The associations between baseline clinical predictors and MDHAQ pain at baseline and 1 year were assessed by using multivariable linear regression. Among the 865 patients with data at baseline and 1 year, 157 (18.2%) met DAS28-CRP4 remission criteria at both time points. Thirty-seven (4.3%) met the ACR/EULAR remission criteria at baseline and 1 year. The prevalence of clinically significant pain (MDHAQ pain ≥4) at baseline ranged from 11.9% among patients meeting DAS28-CRP4 remission criteria to none among patients meeting ACR/EULAR remission criteria. Patient global assessment, MDHAQ function, MDHAQ fatigue, MDHAQ sleep, and arthritis self-efficacy were significantly associated with MDHAQ pain in cross-sectional (P ≤ 0.0005) and longitudinal analyses (P ≤ 0.03). Low swollen-joint counts were associated with high MDHAQ pain in longitudinal analyses (P = 0.02) but not cross-sectional analyses. Other measures of inflammatory disease activity and joint damage were not significantly associated with MDHAQ pain at baseline or at 1 year. Clinically significant pain continues among a substantial proportion of

  15. Phase Velocity and Full-Waveform Analysis of Co-located Distributed Acoustic Sensing (DAS) Channels and Geophone Sensor

    NASA Astrophysics Data System (ADS)

    Parker, L.; Mellors, R. J.; Thurber, C. H.; Wang, H. F.; Zeng, X.

    2015-12-01

    A 762-meter Distributed Acoustic Sensing (DAS) array with a channel spacing of one meter was deployed at the Garner Valley Downhole Array in Southern California. The array was approximately rectangular with dimensions of 180 meters by 80 meters. The array also included two subdiagonals within the rectangle along which three-component geophones were co-located. Several active sources were deployed, including a 45-kN, swept-frequency, shear-mass shaker, which produced strong Rayleigh waves across the array. Both DAS and geophone traces were filtered in 2-Hz steps between 4 and 20 Hz to obtain phase velocities as a function of frequency from fitting the moveout of travel times over distances of 35 meters or longer. As an alternative to this traditional means of finding phase velocity, it is theoretically possible to find the Rayleigh-wave phase velocity at each point of co-location as the ratio of DAS and geophone responses, because DAS is sensitive to ground strain and geophones are sensitive to ground velocity, after suitable corrections for instrument response (Mikumo & Aki, 1964). The concept was tested in WPP, a seismic wave propagation program, by first validating and then using a 3D synthetic, full-waveform seismic model to simulate the effect of increased levels of noise and uncertainty as data go from ideal to more realistic. The results obtained from this study provide a better understanding of the DAS response and its potential for being combined with traditional seismometers for obtaining phase velocity at a single location. This analysis is part of the PoroTomo project (Poroelastic Tomography by Adjoint Inverse Modeling of Data from Seismology, Geodesy, and Hydrology, http://geoscience.wisc.edu/feigl/porotomo).

  16. DAS181 for Treatment of Parainfluenza Virus Infections in Hematopoietic Stem Cell Transplant Recipients at a Single Center.

    PubMed

    Salvatore, Mirella; Satlin, Michael J; Jacobs, Samantha E; Jenkins, Stephen G; Schuetz, Audrey N; Moss, Ronald B; Van Besien, Koen; Shore, Tsiporah; Soave, Rosemary

    2016-05-01

    Parainfluenza virus (PIV) causes severe respiratory infections in hematopoietic stem cell transplant (HSCT) recipients. Currently, no effective therapies are available. DAS181 is a novel antiviral agent that inhibits attachment of PIV to respiratory cells, but clinical data on the use of DAS181 for PIV infection are limited to case reports. We report the clinical manifestations and outcomes of 16 HSCT recipients who received DAS181 daily for the treatment of PIV infection through a compassionate-use protocol or a single-arm clinical trial. Of the 16 patients (clinical trial: 9; compassionate use: 7), 13 were allogeneic HSCT recipients and 8 had graft-versus-host disease. PIV types were 3 (n = 7), 4 (n = 5), 1 (n = 3), and type 3 and 4 coinfection (n = 1). Fourteen patients had pneumonia. All patients presented with cough, 14 had dyspnea, 11 had hypoxia, and 8 had a fever. Patients received 5 to 10 days of treatment. Nine patients (56%) had a complete clinical response after DAS181 therapy and 4 (25%) had a partial response. The 3 patients without a clinical response had coinfections with other pathogens. Of the 7 patients with virologic and spirometric data, 5 had >1-log reduction in nasopharyngeal swab PIV viral load and 4 had improved forced expiratory volumes by the end of treatment. Three patients (19%) died within 30 days and 2 of these deaths were related to PIV infection. Our data suggest that DAS181 may be an effective therapy for PIV pneumonia in HSCT recipients. Randomized placebo-controlled trials are needed to better evaluate its efficacy.

  17. (Re)locating (I)dentity With(in) Politicized (Re)presentation of Fe/Male Body in Kamala Das' Poetry

    ERIC Educational Resources Information Center

    Sultana, Sharmin; Sarwar, Nadia

    2016-01-01

    This paper is going to argue that the selected poems of renowned Indian poet Kamala Das are inclined to relocate both feminine and masculine identity through the politicized representation of body. Kamala Das' representation of body in her poems has always been viewed as a medium of re-historicizing the pain, sufferings, and psychological trauma…

  18. Crystal Structures of the Global Regulator DasR from Streptomyces coelicolor: Implications for the Allosteric Regulation of GntR/HutC Repressors

    PubMed Central

    Fillenberg, Simon B.; Friess, Mario D.; Körner, Samuel; Böckmann, Rainer A.; Muller, Yves A.

    2016-01-01

    Small molecule effectors regulate gene transcription in bacteria by altering the DNA-binding affinities of specific repressor proteins. Although the GntR proteins represent a large family of bacterial repressors, only little is known about the allosteric mechanism that enables their function. DasR from Streptomyces coelicolor belongs to the GntR/HutC subfamily and specifically recognises operators termed DasR-responsive elements (dre-sites). Its DNA-binding properties are modulated by phosphorylated sugars. Here, we present several crystal structures of DasR, namely of dimeric full-length DasR in the absence of any effector and of only the effector-binding domain (EBD) of DasR without effector or in complex with glucosamine-6-phosphate (GlcN-6-P) and N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Together with molecular dynamics (MD) simulations and a comparison with other GntR/HutC family members these data allowed for a structural characterisation of the different functional states of DasR. Allostery in DasR and possibly in many other GntR/HutC family members is best described by a conformational selection model. In ligand-free DasR, an increased flexibility in the EBDs enables the attached DNA-binding domains (DBD) to sample a variety of different orientations and among these also a DNA-binding competent conformation. Effector binding to the EBDs of DasR significantly reorganises the atomic structure of the latter. However, rather than locking the orientation of the DBDs, the effector-induced formation of β-strand β* in the DBD-EBD-linker segment merely appears to take the DBDs ‘on a shorter leash’ thereby impeding the ‘downwards’ positioning of the DBDs that is necessary for a concerted binding of two DBDs of DasR to operator DNA. PMID:27337024

  19. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Hughes, Mark S.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition systems (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis development and deployment.

  20. Proving the Orbits of the Galilean Moons Through Astrophotography. (Spanish Title: Comprobando Las Órbitas de Las Lunas Galileanas a Través de la Astrofotografía.) Evidenciando as Órbitas das Luas Galileanas Atravéd da Astrofotografia

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo

    2009-12-01

    An activity related to the observation of the Galilean moons and to amateur astrophotography is presented in this work. Through the reading of excerpts of the book Sidereus Nuncius (Sidereal Messenger), by Galileo, it is possible to trace a methodology to observe the planet and its natural satellites and, with the aid of the astrophotography, to analyze the field recordings. Moreover, it is possible to compare the images obtained after plotting the relative positions of these moons to prove their orbits. This activity can be conducted by teachers, students and amateur astronomers, in order to develop their capabilities of observation of astronomical phenomena. Se presenta en este trabajo una actividad relacionada a la observación de las lunas Galileanas y a la astrofotografía amateur. A través de la lectura de tramos de la obra Sidereus Nuncius (El Mensajero Sideral) de Galileo, es posible trazar una metodología para la observación del planeta y de sus satélites naturales y, con el auxilio de la astrofotografía, analizar las anotaciones de campo. Además, es posible comparar las imágenes obtenidas con el gráfico de las posiciones relativas de estas lunas para comprobar sus órbitas. Esa actividad puede ser realizada por maestros, estudiantes y astrónomos amateurs, de forma a desarrollar sus capacidades de observación de los fenómenos astronómicos. Uma atividade relacionada à observação das luas Galileanas e à astrofotografia amadora é apresentada neste trabalho. Através da leitura de trechos da obra Sidereus Nuncius (Mensageiro Sideral), de Galileu, é possível traçar uma metodologia para a observação do planeta e de seus satélites naturais e, com o auxílio da astrofotografia, analisar as anotações de campo. Além disso, é possível comparar as imagens obtidas com o gráfico das posições relativas destas luas para evidenciar suas órbitas. Essa atividade pode ser realizada por professores, estudantes e astrônomos amadores, de forma a

  1. The Trigger and Data Acquisition System (TriDAS) of the KM3NeT experiment

    NASA Astrophysics Data System (ADS)

    Pellegrino, C.; KM3NeT Collaboration

    2016-01-01

    Starting from 2015, the new generation underwater high energy neutrino telescope, KM3NeT, is being installed in the Mediterranean Sea. During Phase 1, 32 Detection Units (8 tower-like and 24 string-like) will be deployed in the Ionian Sea, about 100km offshore Portopalo di Capo Passero, Sicily, and 7 string-like DUs will be deployed in the MEUST site, offshore Toulon in France. During Phase 2, several hundreds of DUs will be added to the Phase 1 detector, reaching an effective detection volume of some cubic kilometres. In this contribution the Trigger and Data Acquisition System (TriDAS) of the string-based detector is described. The TriDAS is designed to scale with the detector size, allowing the read-out and the on-line trigger of data from both Phase 1 and Phase 2, whose continuous throughputs are expected to be about 10Gbps and more than 250Gbps, respectively.

  2. Sensitivity of Global Modeling Initiative CTM predictions of Antarctic ozone recovery to GCM and DAS generated meteorological fields

    SciTech Connect

    Rotman, D; Bergmann, D

    2003-12-04

    We use the Global Modeling Initiative chemistry and transport model to simulate the evolution of stratospheric ozone between 1995 and 2030, using boundary conditions consistent with the recent World Meteorological Organization ozone assessment. We compare the Antarctic ozone recovery predictions of two simulations, one driven by meteorological data from a general circulation model (GCM), the other using the output of a data assimilation system (DAS), to examine the sensitivity of Antarctic ozone recovery predictions to the characteristic dynamical differences between GCM and DAS-generated meteorological data. Although the age of air in the Antarctic lower stratosphere differs by a factor of 2 between the simulations, we find little sensitivity of the 1995-2030 Antarctic ozone recovery between 350 K and 650 K to the differing meteorological fields, particularly when the recovery is specified in mixing ratio units. Relative changes are smaller in the DAS-driven simulation compared to the GCM-driven simulation due to a surplus of Antarctic ozone in the DAS-driven simulation which is not consistent with observations. The peak ozone change between 1995 and 2030 in both simulations is {approx}20% lower than photochemical expectations, indicating that changes in ozone transport at 450 K between 1995 and 2030 constitute a small negative feedback. Total winter/spring ozone loss during the base year (1995) of both simulations and the rate of ozone loss during August and September is somewhat weaker than observed. This appears to be due to underestimates of Antarctic Cl{sub y} at the 450 K potential temperature level.

  3. Correlation between DAS-28 and neopterin as a biochemical marker of immune system activation in early rheumatoid arthritis.

    PubMed

    D'agostino, Liliana Elena; Ventimiglia, Fernando; Verna, Juan Antonio; Colina, Amelia De La; Aguirre, Yanina; Arturi, Alfredo; Capparelli, Alberto

    2013-02-01

    The objective of this study was to evaluate neopterin plasma concentrations in patients with early Rheumatoid Arthritis (RA) and correlate them with disease activity. This is a 28-month prospective study carried out on 65 individuals. There were 27 patients with early RA and 38 healthy volunteers as control group. Enzyme immunoassay was used to measure concentrations of neopterin and anti-cyclic citrullinated peptide (CCP) antibodies. Rheumatoid factor (RF) and C-reactive protein (CRP) were measured turbidimetrically, and antinuclear antibodies (ANA) were detected by immunofluorescence. Patients with early RA disease activity were divided into 4 groups according to DAS-28 criteria. Neopterin concentrations in RA patients were compared to conventional RA diagnostic serological markers. Healthy volunteers had a mean neopterin concentration of 5.63 ± 0.38 [1.36-9.93] nmol. L(- 1). A statistically significant elevation of neopterin mean concentration was found on early RA patients: mean value of 8.92 ± 0.93 [3.94-28.3] nmol. L(- 1) (p < 0.001). Pearson product moment correlation suggests a correlation between neopterin concentrations and DAS-28 (r = 0.208, p = 0.065). The analysis of the mean values grouped according with the DAS-28 criteria showed a correspondence between these means, with a Pearson correlation coefficient r = 0.979, p = 0.021. CRP concentrations also showed a similar trend. Anti-CCP antibodies and RF revealed a positive relationship with RA activity. Such a correlation was not found with ANA results. The elevation of plasma neopterin concentrations in early RA patients may indicate stimulation of immune response. Good correlation between neopterin concentrations and DAS-28 may facilitate assessing disease activity.

  4. Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients.

    PubMed

    Bıyıkoğlu, Başak; Buduneli, Nurcan; Aksu, Kenan; Nalbantsoy, Ayşe; Lappin, David F; Evrenosoğlu, Evren; Kinane, Denis F

    2013-10-01

    To evaluate clinical outcomes and effects of non-surgical periodontal therapy on serum, gingival crevicular fluid (GCF) interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels in chronic periodontitis patients with/without rheumatoid arthritis (RA), fifteen RA patients with chronic periodontitis (RA-P) and 15 systemically healthy non-RA chronic periodontitis patients (H-P) were recruited. Clinical periodontal recordings, GCF, and blood samples were obtained at baseline, 1, 3, and 6 months after periodontal treatment. GCF, serum IL-1β, TNF-α levels were analyzed by ELISA. Disease activity score 28 (DAS28) was used to assess RA clinical morbidity. Study groups were compared by Mann-Whitney U test. Wilcoxon test was used to compare the data at baseline, 1, 3, and 6 months after periodontal therapy within the same group. DAS28 decreased significantly after periodontal therapy in RA-P group (p < 0.01). Serum TNF-α concentrations of H-P group were significantly higher than those of RA-P group (p < 0.01), whereas IL-1β levels were similar. No significant change was observed in serum levels of these cytokines after periodontal therapy. GCF IL-1β amounts decreased significantly in both groups following treatment (p < 0.01). At 6-months, H-P GCF IL-1β concentrations were significantly lower than baseline. DAS28 and GCF IL-1β correlated with clinical periodontal indices (p < 0.01). Significant decreases in DAS28 and GCF IL-1β amounts after periodontal treatment suggest that periodontal therapy synergizes with systemic RA therapy to improve RA status.

  5. MiDas: automatic extraction of a common domain of discourse in sleep medicine for multi-center data integration.

    PubMed

    Sahoo, Satya S; Ogbuji, Chimezie; Luo, Lingyun; Dong, Xiao; Cui, Licong; Redline, Susan S; Zhang, Guo-Qiang

    2011-01-01

    Clinical studies often use data dictionaries with controlled sets of terms to facilitate data collection, limited interoperability and sharing at a local site. Multi-center retrospective clinical studies require that these data dictionaries, originating from individual participating centers, be harmonized in preparation for the integration of the corresponding clinical research data. Domain ontologies are often used to facilitate multi-center data integration by modeling terms from data dictionaries in a logic-based language, but interoperability among domain ontologies (using automated techniques) is an unresolved issue. Although many upper-level reference ontologies have been proposed to address this challenge, our experience in integrating multi-center sleep medicine data highlights the need for an upper level ontology that models a common set of terms at multiple-levels of abstraction, which is not covered by the existing upper-level ontologies. We introduce a methodology underpinned by a Minimal Domain of Discourse (MiDas) algorithm to automatically extract a minimal common domain of discourse (upper-domain ontology) from an existing domain ontology. Using the Multi-Modality, Multi-Resource Environment for Physiological and Clinical Research (Physio-MIMI) multi-center project in sleep medicine as a use case, we demonstrate the use of MiDas in extracting a minimal domain of discourse for sleep medicine, from Physio-MIMI's Sleep Domain Ontology (SDO). We then extend the resulting domain of discourse with terms from the data dictionary of the Sleep Heart and Health Study (SHHS) to validate MiDas. To illustrate the wider applicability of MiDas, we automatically extract the respective domains of discourse from 6 sample domain ontologies from the National Center for Biomedical Ontologies (NCBO) and the OBO Foundry.

  6. MoSST DAS: The First Working Geomagnetic Data Assimilation System

    NASA Technical Reports Server (NTRS)

    Kuang, Weijia; Wei, Zigang; Tangborn, Andrew

    2011-01-01

    The Earth possesses an internal magnetic field (geomagnetic field) generated by convection in the outer core (geodynamo). Previous efforts have been focused along two distinct paths: (1) numerical geodynamo modeling to understand the origin of the geomagnetic field, and the mechanisms of geomagnetic secular variations (SV); and (2) geomagnetic field modeling to map the spatial/temporal variations of the field from geomagnetic data, and to derive core properties, e.g. inversion of core flow near the core-mantle boundary (CMB). Geomagnetic data assimilation is a new approach emerged over the past 5 years: surface observations are assimilated with geodynamo models for better understanding of the core dynamical state, and accurately prediction of SV. In collaboration with several geomagnetic research groups, we have developed the first working geomagnetic data assimilation system, Modular, Scalable, Self-consistent, and Three-dimensional (MoSST) DAS, that includes the MoSST numerical dynamo model; 7000 years of geomagnetic field maps from several field models utilizing satellite and ground observatory data, historical magnetic records and archeo/paleo magnetic data; and an ensemble based optimal interpolation (01) assimilation algorithm. With this system, we have demonstrated clearly that the assimilated core dynamical state is substantially different from those of pure geodynamo simulations. Ensemble assimilation runs also show the convergence of the assimilated solutions inside the core, suggesting that the simulation state is pulled closer to the truth via data assimilation. The forecasts from this system are also very accurate: the 5-year forecast of the geomagnetic field agrees very well with the observations; and the 5-year secular variation forecast is more accurate than the IGRF SV forecast models in the past. Using geomagnetic records up to 2009, we have made an SV forecast for the period from 2010-2015, and is a candidate SV model for IGRF-11.

  7. A novel abundant family of retroposed elements (DAS-SINEs) in the nine-banded armadillo (Dasypus novemcinctus).

    PubMed

    Churakov, Gennady; Smit, Arian F A; Brosius, Jürgen; Schmitz, Jürgen

    2005-04-01

    About half of the mammalian genome is composed of retroposons. Long interspersed elements (LINEs) and short interspersed elements (SINEs) are the most abundant repetitive elements and account for about 21% and 13% of the human genome, respectively. SINEs have been detected in all major mammalian lineages, except for the South American order Xenarthra, also termed Edentata (armadillos, anteaters, and sloths). Investigating this order, we discovered a novel high-copy-number family of tRNA derived SINEs in the nine-banded armadillo Dasypus novemcinctus, a species that successfully crossed the Central American land bridge to North America in the Pliocene. A specific computer algorithm was developed, and we detected and extracted 687 specific SINEs from databases. Termed DAS-SINEs, we further divided them into six distinct subfamilies. We extracted tRNA(Ala)-derived monomers, two types of dimers, and three subfamilies of chimeric fusion products of a tRNA(Ala) domain and an approximately 180-nt sequence of thus far unidentified origin. Comparisons of secondary structures of the DAS-SINEs' tRNA domains suggest selective pressure to maintain a tRNA-like D-arm structure in the respective founder RNAs, as shown by compensatory mutations. By analysis of subfamily-specific genetic variability, comparison of the proportion of direct repeats, and analysis of self-integrations as well as key events of dimerization and deletions or insertions, we were able to delineate the evolutionary history of the DAS-SINE subfamilies.

  8. Grazing behaviour and dry matter intake of llamas (Lama glama) and German black- head mutton sheep (Ovis orientalis forma aries) under Central European conditions.

    PubMed

    Stölzl, Anna Maria; Lambertz, Christian; Gauly, Matthias

    2015-01-01

    The aim of the present study was to assess the behaviour of llamas (Lama glama) and German blackhead mutton sheep (Ovis orientalis forma aries) when kept under Central European grazing conditions. In total, six adult female sheep and six adult female llamas were observed by direct observation during one week, in which each group was observed for a total time of 24 h. The animals were kept on the same pasture, but the species were raised in separate plots. Forage height before and after the experimental period were determined using a rising plate meter to calculate the average daily dry matter intake (DMI). Llamas had a daily DMI of 0.85%/BW and sheep of 1.04%/BW, respectively. The following behaviours were recorded by direct observation: grazing standing up, grazing lying down, ruminating standing up, ruminating lying down, lying down, lying down lateral and standing. Both species grazed for more than 50% of the time. Ruminating was predominantly performed while standing and lying by sheep (about 50% of the night and 12% of the day) and while lying by llamas (54% of the night and 10% of the day). In conclusion, sheep and llamas differed in grazing behaviour and daily biorhythm. These differences indicate that sheep and llamas may not synchronize their behaviour when co-grazed, though particularly in co-grazing studies the observation period should be extended.

  9. Determining the Shape of the Orbit of Mars in the High School. (Spanish Title: Determinación de la Forma de la Órbita de Marte en la Escuela Secundaria.) Determinando a Forma da Órbita de Marte no Ensino Médio

    NASA Astrophysics Data System (ADS)

    Dutra, Carlos Maximiliano; Rossini Goulart, Andressa

    2014-12-01

    In the present work, in order to supply the lacks of practical activities related to the content of Kepler's Laws in high school physics textbooks, we present a practical activity to determine the shape of the orbit of Mars. In this activity the student can experience the discovery the shape of the orbit of Mars in a way similar to that realized by Johannes Kepler combining the physical concepts with geometry. We applied the activity to eighteen high school teachers participating in a Postgraduate Course in Science Education. After two hours of work the group obtained the shape of the orbit of Mars and estimated its orbital parameters with a relative error less than 14%. En el presente trabajo y con el objetivo de reducir la escasez de actividades prácticas relacionadas con el contenido de las leyes de Kepler en libros de texto de física de la escuela secundaria, se presenta una actividad práctica para determinar la forma de la órbita de Marte. En esta actividad el estudiante puede vivir la experiencia de descubrir la forma de la órbita de Marte de una manera similar a la realizada por Johannes Kepler combinando los conceptos físicos con la geometría. Aplicamos la actividad a dieciocho maestros de escuelas secundarias en un Curso de Especialización en Enseñanza de las Ciencias. Después de dos horas de trabajo el grupo obtuvo la forma de la órbita de Marte com error inferior al 14% en los parámetros orbitales. No presente trabalho, visando suprir a deficiência de atividades práticas relacionadas ao conteúdo de Leis de Kepler nos livros-textos de Física do 1º ano do Ensino Médio, apresentamos uma atividade prática de determinação da órbita de Marte. O aluno, combinando conceitos físicos com a geometria poderá vivenciar a experiência da descoberta da forma da órbita de Marte de modo similar ao realizado por Johannes Kepler. Aplicamos a metodologia proposta junto a dezoito professores do Curso de Especialização em Educação em Ciências e

  10. Restructuring of Epibacterial Communities on Fucus vesiculosus forma mytili in Response to Elevated pCO2 and Increased Temperature Levels.

    PubMed

    Mensch, Birte; Neulinger, Sven C; Graiff, Angelika; Pansch, Andreas; Künzel, Sven; Fischer, Martin A; Schmitz, Ruth A

    2016-01-01

    Marine multicellular organisms in composition with their associated microbiota-representing metaorganisms-are confronted with constantly changing environmental conditions. In 2110, the seawater temperature is predicted to be increased by ~5°C, and the atmospheric carbon dioxide partial pressure (pCO2) is expected to reach approximately 1000 ppm. In order to assess the response of marine metaorganisms to global changes, e.g., by effects on host-microbe interactions, we evaluated the response of epibacterial communities associated with Fucus vesiculosus forma mytili (F. mytili) to future climate conditions. During an 11-week lasting mesocosm experiment on the island of Sylt (Germany) in spring 2014, North Sea F. mytili individuals were exposed to elevated pCO2 (1000 ppm) and increased temperature levels (Δ+5°C). Both abiotic factors were tested for single and combined effects on the epibacterial community composition over time, with three replicates per treatment. The respective community structures of bacterial consortia associated to the surface of F. mytili were analyzed by Illumina MiSeq 16S rDNA amplicon sequencing after 0, 4, 8, and 11 weeks of treatment (in total 96 samples). The results demonstrated that the epibacterial community structure was strongly affected by temperature, but only weakly by elevated pCO2. No interaction effect of both factors was observed in the combined treatment. We identified several indicator operational taxonomic units (iOTUs) that were strongly influenced by the respective experimental factors. An OTU association network analysis revealed that relationships between OTUs were mainly governed by habitat. Overall, this study contributes to a better understanding of how epibacterial communities associated with F. mytili may adapt to future changes in seawater acidity and temperature, ultimately with potential consequences for host-microbe interactions.

  11. Restructuring of Epibacterial Communities on Fucus vesiculosus forma mytili in Response to Elevated pCO2 and Increased Temperature Levels

    PubMed Central

    Mensch, Birte; Neulinger, Sven C.; Graiff, Angelika; Pansch, Andreas; Künzel, Sven; Fischer, Martin A.; Schmitz, Ruth A.

    2016-01-01

    Marine multicellular organisms in composition with their associated microbiota—representing metaorganisms—are confronted with constantly changing environmental conditions. In 2110, the seawater temperature is predicted to be increased by ~5°C, and the atmospheric carbon dioxide partial pressure (pCO2) is expected to reach approximately 1000 ppm. In order to assess the response of marine metaorganisms to global changes, e.g., by effects on host-microbe interactions, we evaluated the response of epibacterial communities associated with Fucus vesiculosus forma mytili (F. mytili) to future climate conditions. During an 11-week lasting mesocosm experiment on the island of Sylt (Germany) in spring 2014, North Sea F. mytili individuals were exposed to elevated pCO2 (1000 ppm) and increased temperature levels (Δ+5°C). Both abiotic factors were tested for single and combined effects on the epibacterial community composition over time, with three replicates per treatment. The respective community structures of bacterial consortia associated to the surface of F. mytili were analyzed by Illumina MiSeq 16S rDNA amplicon sequencing after 0, 4, 8, and 11 weeks of treatment (in total 96 samples). The results demonstrated that the epibacterial community structure was strongly affected by temperature, but only weakly by elevated pCO2. No interaction effect of both factors was observed in the combined treatment. We identified several indicator operational taxonomic units (iOTUs) that were strongly influenced by the respective experimental factors. An OTU association network analysis revealed that relationships between OTUs were mainly governed by habitat. Overall, this study contributes to a better understanding of how epibacterial communities associated with F. mytili may adapt to future changes in seawater acidity and temperature, ultimately with potential consequences for host-microbe interactions. PMID:27065988

  12. Forms of Appropriation of Tools for the Astronomy Education in Continuous Training of Teachers. (Spanish Title: Formas de Apropriación de Herramientas Para la Enseñanza de la Astronomía en la Formación Docente Continua.) Formas de Apropriação de Instrumentos Para o Ensino de Astronomia na Formação Continuada de Professores

    NASA Astrophysics Data System (ADS)

    Marques Soares, Leonardo; Sousa Nascimento, Silvania

    2012-07-01

    siete relatos. O objetivo principal desse artigo é apresentar algumas reflexões sobre a maneira como um grupo de professores se apropriaram dos instrumentos do KIT PARA O ENSINO DE ASTRONOMIA (KITPEA). Os sujeitos dessa pesquisa participaram do curso de especialização em ensino de astronomia oferecido pelo Projeto de Formação Continuada (Foco) no Centro de Ensino de Ciências e Matemática (CECIMIG) da Faculdade de Educação da Universidade Federal de Minas Gerais (FaE/UFMG). Coletamos as informações por meio de um questionário e de uma entrevista, aplicados a esses professores. Estruturamos a análise dessas informações com a ajuda da Teoria da Atividade e da Teoria da Ação Mediada. Interpretamos as falas dos professores usando como dispositivo analítico os elementos constituintes do sistema de atividade e os conceitos de apropriação e domínio. Dentre os 11 sujeitos que participaram da pesquisa, foi possível identificar a apropriação dos instrumentos em 7 narrativas.

  13. Predictors of European League Against Rheumatism (EULAR) good response, DAS-28 remission and sustained responses to TNF-inhibitors in rheumatoid arthritis: a prospective study in refractory disease.

    PubMed

    Mohammed, Reem Hamdy A; Farahat, Faisal; Kewan, Hanady H; Bukhari, Mohammed A

    2015-01-01

    The aim of this study was to survey factors related to EULAR good response, the DAS-28 definition of remission, ACR 50 response, sustained response to tumor necrosis factor inhibitors (TNF-I) therapy in biologic naïve patients with refractory rheumatoid arthritis. This was a single center observational clinical prospective 2 years' study, EULAR response criteria, DAS 28, HAQ and radiographic changes were recorded. Eighty patients included (64 females and 16 males, mean age was 48.4 + -17.9 years, mean disease duration 7.3 + -5.9 years). At 6 months 70% achieved EULAR good response, 51.8% achieved DAS-28 remission. Good response/sustained responses inversely correlated with baseline DAS-28 and radiographic erosions P <0.05. EULAR good response/remission by 6 months, sustained response at 2 years positively correlated with the decline in RF titers (r = 0.33, P < 0.05 & r = 0.30, P < 0.03 respectively), negatively correlated with the baseline HAQ. Regression analysis identified higher serum hemoglobin concentration, lower baseline HAQ scores, and the absence of radiographic erosions as significant predictors of good as well as sustained responses after adjustment for potential covariates. Methotrexate was associated with favorable responses and remission at 6 months (ORs = 1.13, 1.30 respectively). The study concluded that a lower baseline DAS-28 and HAQ scores, the lack of radiographic erosions favored EULAR good response and were significant predictors of sustained response to TNF-I.

  14. Properties of Noise Cross Correlation Functions Obtained from a Distributed Acoustic Sensing (DAS) Array at Garner Valley, California

    NASA Astrophysics Data System (ADS)

    Zeng, X.; Lancelle, C.; Thurber, C. H.; Fratta, D.; Wang, H. F.; Chalari, A.; Clarke, A.

    2015-12-01

    The field test of Distributed Acoustic Sensing (DAS) conducted at Garner Valley, California on September 11-12, 2013 provided a continuous overnight record of ambient noise. The DAS array recorded ground motions every one meter of optical cable that was arranged approximately in the shape of a rectangle with dimensions of 160 m by 80 m. The long dimension of the array was adjacent to a state highway. Three hours of record were used to compute noise cross-correlation functions (NCFs) in one-minute windows. The trace from each sensor channel was pre-processed by downsampling to 200 Hz, followed by normalization in the time-domain and bandpass filtering between 2 and 20 Hz (Bensen et al., 2007). The one-minute NCFs were then stacked using the time-frequency domain phase-weighted stacking method (Schimmel & Gallart, 2007). The NCFs between channels were asymmetrical reflecting the direction of traffic noise. The group velocities were found using the frequency-time analysis method. The energy was concentrated between 5 and 15 Hz, which falls into the typical traffic noise frequency band. The resulting velocities were between 100 and 300 m/s for frequencies between 10 and 20 Hz, which are in the same range as described in the results for surface-wave dispersion obtained using an active source for the same site (Lancelle et al., 2015). The group velocity starts to decrease for frequencies greater than ~10 Hz, which was expected on the basis of a previous shear-wave velocity model (Steidl et al., 1996). Then, the phase velocity was calculated using the multichannel analysis of surface wave technique (MASW - Park et al., 1999) with 114 NCFs spaced one meter apart. The resulting dispersion curve between 5 and 15 Hz gave phase velocities that ranged from approximately 170 m/s at 15 Hz to 250 m/s at 5 Hz. These results are consistent with other results of active-source DAS and seismometer records obtained at the Garner Valley site (e.g., Stokoe et al. 2004). This analysis is

  15. Antimicrobial activity of plants used as medicinals on an indigenous reserve in Rio das Cobras, Paraná, Brazil.

    PubMed

    Moura-Costa, Gislaine F; Nocchi, Samara R; Ceole, Ligia F; de Mello, João Carlos P; Nakamura, Celso Vataru; Dias Filho, Benedito Prado; Temponi, Livia G; Ueda-Nakamura, Tania

    2012-09-28

    A considerable percentage of global biodiversity is located in Brazil, a country that also has rich cultural and ethnic diversity. In the community of Rio das Cobras, Paraná, plants are still widely used in the health care not only by indigenous people but also by the non-indigenous population that inhabits the region. The investigation of the efficacy and safety of these plants in the treatment of infectious diseases provides insights for future studies of these species allowing the appropriated use by the indigenous people, since few or none study has been conducted so far. Evaluate the antimicrobial activity and cytotoxicity of some plants used as medicinal on an indigenous reserve in Rio das Cobras, Paraná, Brazil. The aqueous extracts were obtained by decoction and the 50% and 70% hydroalcoholic extracts by turbo extraction. The extracts were tested against strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Candida albicans, Candida parapsilosis, Candida tropicalis, Leishmania amazonensis, Poliovirus and HSV-1. Cytotoxicity assay using VERO cells were also performed. None of the extracts had a selectivity index (SI)>1 for any of the tested bacteria. Only Campomanesia eugenioides and Schinus terebinthifolius had an SI>1.0 for all of the tested Candida species. The best anti-Leishmania activity was obtained with Zanthoxylum rhoifolium and Schinus terebinthifolius. Extracts of Cordia americana were the most effective against herpes simplex virus type 1. Zanthoxylum rhoifolium was the most effective against Poliovirus, and Ocimum gratissimum was effective against both Poliovirus and Herpes Simplex virus. Among the plants investigated in the present study, Zanthoxylum rhoifolium had the fewest cytotoxic effect. The plants investigated in the present study exhibited potential for future pharmacological uses, but additional studies, especially with regard to in vivo toxicity, must be conducted. The results of this

  16. Insect-Protected Event DAS-81419-2 Soybean (Glycine max L.) Grown in the United States and Brazil Is Compositionally Equivalent to Nontransgenic Soybean

    PubMed Central

    2015-01-01

    The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated. PMID:25641393

  17. Insect-protected event DAS-81419-2 soybean (Glycine max L.) grown in the United States and Brazil is compositionally equivalent to nontransgenic soybean.

    PubMed

    Fast, Brandon J; Schafer, Ariane C; Johnson, Tempest Y; Potts, Brian L; Herman, Rod A

    2015-02-25

    The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated.

  18. Priming index of the Spanish word fragments from the Dasí, Soler, and Ruiz (2004) database.

    PubMed

    Dasí, Carmen; Soler, María José; Ruiz, Juan Carlos

    2007-08-01

    Word-fragment completion is a frequently used test in implicit memory research. A database of 196 Spanish fragments was recently published (Dasí, Soler, & Ruiz, 2004) in which the fragments were described for indices, such as difficulty, familiarity, frequency, number of meanings, and so on (www.psychonomic.org/archive). In this work, a new index, the priming index, is described for the same 196 fragments. This index is calculated for each fragment by subtracting the difficulty index (the proportion of correct completion when the fragment is not studied) from the proportion of correct completion when the fragment is studied, and it means the capacity of an item to be primed. In order to determine whether the new index performs well, we have replicated some important experimental effects, such as priming, frequency, and difficulty. We consider that this index can help researchers to better select stimuli for fragment-completion tasks.

  19. Das Märchen vom Zauberer im weißen Kittel: Mythen um berühmte Experimente und Experimentatoren

    NASA Astrophysics Data System (ADS)

    Hentschel, Klaus

    2003-09-01

    Um berühmte Experimentatoren und Experimente ranken sich ebenso Mythen wie um geniale Theoretiker. Sie sind in populärwissenschaftlichen Büchern, Lehrbüchern und sogar in wissenschaftshistorischen Texten verbreitet. Die durch die Aufklärung etablierte Kultur des eleganten Schauexperiments vermittelt ein schiefes Bild vom mühsamen Weg vieler Experimentatoren zum dargestellten Ergebnis. Auch der Mythos des einsamen, genialen Experimentators ohne Helfer widerspricht dem historischen Befund. Gleiches gilt für das experimentum crucis, das eine Theorie als entscheidendes Experiment belegen soll. Die historische Forschung zeigt, dass es eine lange, eigenständige Tradition der experimentellen und instrumentellen Arbeit gibt.

  20. Development of a surface-wave imaging system for geotechnical applications based on distributed acoustic sensing (DAS) and ambient noise interferometry

    NASA Astrophysics Data System (ADS)

    Ajo Franklin, J. B.; Daley, T. M.; Freifeld, B. M.; Tang, D. G.; Zhang, R.; Wagner, A. M.; Dou, S.; Lindsey, N.; Bjella, K.; Pevzner, R.

    2014-12-01

    Distributed fiber-optic sensing methods have been used since the 1980's for continuous monitoring of near-surface soil properties, typically exploiting Raman scattering to measure temperature (DTS) or stimulated Brillouin scattering to measure strain (DSS). Recent advances in high speed measurement of Rayleigh scattering has enabled distributed recording of seismic waves over long sections of fiber; this approach, referred to as distributed acoustic sensing (DAS) has the potential to allow nearly continuous monitoring of near-surface mechanical properties, a crucial target for geotechnical management of infrastructure dependent on soil strength. We present initial results from our effort to build a real-time soil property monitoring system based on DAS; our approach employs seismic interferometry and dispersion analysis of ambient noise generated by infrastructure to provide a continuously updated model of shear modulus. Our preliminary results include an in-depth investigation of DAS fiber response in the context of active sources; this component of our study verifies classical models for the azimuthal response of straight fibers to propagating surface waves. We also explore the "noisescape" of linear infrastructure and show a usable seismic signal band of 8-40 hz at a series of sites, primarily consisting of Rayleigh waves. Finally, we present preliminary results from a DAS monitoring array installed at the Richmond Field Station near a heavily used road and compare interferometric processing of the acquired data to that generated by surface deployment of geophones.

  1. Inhibition of Primary Clinical Isolates of Human Parainfluenza Virus by DAS181 in Cell Culture and in a Cotton Rat Model

    PubMed Central

    Jones, B. G.; Hayden, R.T.; Hurwitz, J. L.

    2013-01-01

    DAS181 is a novel drug in development for the treatment of influenza as well as human parainfluenza viruses (hPIV). Previous studies demonstrated that DAS181 inhibited laboratory strains of hPIV, but no tests were conducted with primary clinical isolates of hPIV. To fill this gap, we studied six primary isolates including hPIV-2 and hPIV-3. First tests showed that the amplification of all viruses in vitro was reproducibly inhibited with DAS181 drug concentrations ranging between 0.1 and 1 nM. An hPIV-3 primary clinical isolate was then tested in a cotton rat model for sensitivity to 0.3-1 mg/kg drug treatments. Results showed that virus amplification in the lower respiratory tract was significantly and reproducibly inhibited by drug. Together, experiments demonstrated that DAS181 inhibited primary clinical isolates of hPIV in vitro and in vivo at doses similar to those previously described for inhibition of laboratory hPIV and influenza virus isolates. PMID:24076357

  2. Novas determinações dos parâmetros atmosféricos das estrelas anãs brancas DA

    NASA Astrophysics Data System (ADS)

    Giovannini, O.; Costa, A. F. M.; Kepler, S. O.

    2003-08-01

    Nós temos selecionado uma amostra de estrelas anãs brancas DA (atmosfera de hidrogênio) a partir dos índices de Strömgren cujos valores estão próximos a região de instabilidade das estrelas anãs brancas DA variáveis, as chamadas estrelas DAV ou ZZ Ceti. O objetivo é determinar os parâmetros fundamentais (temperatura efetiva, Teff, aceleração da gravidade, log g, e massa) destas estrelas para verificar quais os parâmetros estelares estão envolvidos com o mecanismo de pulsação das estrelas DAV. Nós obtemos, até agora, mais de 120 espectros óticos de estrelas DA. Entre as estrelas selecionadas há 20 estrelas variáveis (DAV). Assim, podemos verificar se existem ou não estrelas não variáveis dentro da faixa de instabilidade das estrelas ZZ Ceti. Neste trabalho nós apresentamos a determinação dos parâmetros atmosféricos (temperatura efetiva, Teff, e aceleração da gravidade, log g) das estrelas anãs brancas DA usando os novos modelos de atmosfera ML2/a = 0.6. Estes modelos têm sido utilizados recentemente por fornecerem uma excelente consistência interna na determinação das temperaturas nas regiões do ultra-violeta e ótico. Os parâmetros atmosféricos são determinados espectroscopicamente através da comparação do fluxo de energia das linhas de Balmer (Hb à H9) entre os espectros observados e sintéticos (gerados pelos modelos de atmosfera). As temperaturas obtidas com os novos modelos são, em geral, menores (~ 1000 K menos) que as temperaturas determinadas anteriormente, com modelos ML1. Os valores de log g não mudaram significativamente (menos de 10%). A faixa de instabilidade das DAVs está entre 11000 e 13000 K, consistente com dados de outros autores.

  3. Three genes encoding citrate synthases in Saccharopolyspora erythraea are regulated by the global nutrient-sensing regulators GlnR, DasR, and CRP.

    PubMed

    Liao, Cheng-Heng; Yao, Li-Li; Ye, Bang-Ce

    2014-10-08

    Saccharopolyspora erythraea has three citrate synthases encoded by gltA-2, citA, and citA4. Here, we characterized and identified the expression and regulatory properties of these synthases. Three pleiotropic global regulatory proteins of S. erythraea - CRP, GlnR, and DasR - are involved in carbon metabolism, nitrogen metabolism, and amino-sugar (chitin and GlcNAc) metabolism. Using electrophoretic mobility shift assays (EMSAs), we identified these regulators as proteins that bind directly to the promoter regions of all citrate synthase genes (gltA-2, citA, and citA4). Footprinting assays indicated the exact protect sequences of CRP, GlnR, and DasR on the promoter region of gltA-2, revealing binding competition between GlnR and DasR. Moreover, by comparing the transcription levels of citrate synthase genes between parental and glnR mutant or dasR mutant strains, or by comparing the transcription response of citrate synthases under various nutrient conditions, we found that GlnR and DasR negatively regulated citA and citA4 transcription but had no regulatory effects on the gltA-2 gene. Although no CRP mutant was available, the results indicated that CRP was a cAMP-binding receptor affecting gltA-2 transcription when the intracellular cAMP concentration increased. Thus, an overall model of CS regulation by C and/or N metabolism regulators and cAMP receptor protein was proposed.

  4. Simulation of the single-vibronic-level emission spectra of HAsO and DAsO

    NASA Astrophysics Data System (ADS)

    Mok, Daniel K. W.; Lee, Edmond P. F.; Dyke, John M.

    2016-05-01

    The single-vibronic-level (SVL) emission spectra of HAsO and DAsO have been simulated by electronic structure/Franck-Condon factor calculations to confirm the spectral molecular carrier and to investigate the electronic states involved. Various multi-reference (MR) methods, namely, NEVPT2 (n-electron valence state second order perturbation theory), RSPT2-F12 (explicitly correlated Rayleigh-Schrodinger second order perturbation theory), and MRCI-F12 (explicitly correlated multi-reference configuration interaction) were employed to compute the geometries and relative electronic energies for the X ˜ 1 A ' and A ˜ 1 A ″ states of HAsO. These are the highest level calculations on these states yet reported. The MRCI-F12 method gives computed T0 (adiabatic transition energy including zero-point energy correction) values, which agree well with the available experimental T0 value much better than previously computed values and values computed with other MR methods in this work. In addition, the potential energy surfaces of the X ˜ 1 A ' and A ˜ 1 A ″ states of HAsO were computed using the MRCI-F12 method. Franck-Condon factors between the two states, which include anharmonicity and Duschinsky rotation, were then computed and used to simulate the recently reported SVL emission spectra of HAsO and DAsO [R. Grimminger and D. J. Clouthier, J. Chem. Phys. 135, 184308 (2011)]. Our simulated SVL emission spectra confirm the assignments of the molecular carrier, the electronic states involved, and the vibrational structures observed in the SVL emission spectra but suggest a loss of intensity in the reported experimental spectra at the low emission energy region almost certainly due to a loss of responsivity near the cutoff region (˜800 nm) of the detector used. Computed and experimentally derived re (equilibrium) and/or r0 {the (0,0,0) vibrational level} geometries of the two states of HAsO are discussed.

  5. Simulation of the single-vibronic-level emission spectra of HAsO and DAsO.

    PubMed

    Mok, Daniel K W; Lee, Edmond P F; Dyke, John M

    2016-05-14

    The single-vibronic-level (SVL) emission spectra of HAsO and DAsO have been simulated by electronic structure/Franck-Condon factor calculations to confirm the spectral molecular carrier and to investigate the electronic states involved. Various multi-reference (MR) methods, namely, NEVPT2 (n-electron valence state second order perturbation theory), RSPT2-F12 (explicitly correlated Rayleigh-Schrodinger second order perturbation theory), and MRCI-F12 (explicitly correlated multi-reference configuration interaction) were employed to compute the geometries and relative electronic energies for the X̃(1)A(') and Ã(1)A(″) states of HAsO. These are the highest level calculations on these states yet reported. The MRCI-F12 method gives computed T0 (adiabatic transition energy including zero-point energy correction) values, which agree well with the available experimental T0 value much better than previously computed values and values computed with other MR methods in this work. In addition, the potential energy surfaces of the X̃(1)A(') and Ã(1)A(″) states of HAsO were computed using the MRCI-F12 method. Franck-Condon factors between the two states, which include anharmonicity and Duschinsky rotation, were then computed and used to simulate the recently reported SVL emission spectra of HAsO and DAsO [R. Grimminger and D. J. Clouthier, J. Chem. Phys. 135, 184308 (2011)]. Our simulated SVL emission spectra confirm the assignments of the molecular carrier, the electronic states involved, and the vibrational structures observed in the SVL emission spectra but suggest a loss of intensity in the reported experimental spectra at the low emission energy region almost certainly due to a loss of responsivity near the cutoff region (∼800 nm) of the detector used. Computed and experimentally derived re (equilibrium) and/or r0 {the (0,0,0) vibrational level} geometries of the two states of HAsO are discussed.

  6. Entomological fauna from Reserva Biológica do Atol das Rocas, RN, Brazil: I. Morphospecies composition.

    PubMed

    Almeida; Marchon-Silva; Ribeiro; Serpa-Filho; Almeida; Costa

    2000-05-01

    Atol das Rocas, the unique atoll in the South-western Atlantic, is located 144 nautical miles (266 Km) northeast from the city of Natal, NE Brazil and 80 nautical miles from Arquipélago de Fernando de Noronha, with geographic co-ordinates 3 masculine51'S and 33 masculine49"W. It's of volcanic origin and coralline formation. The reef is ellipsoid, its largest axis (E-W) is approximately 3.7 km long, and the shortest (N-S) is 2.5 km. Inside the lagoon, there are two islands: the Ilha do Farol and Ilha do Cemitério, which comprehend 7.2 Km2 of emerged area. The Atol das Rocas lodges 143,000 birds, mainly by Sula dactilatra, S. leucogaster, Anous stolidus, A. minuta and Sterna fuscata. Due to their remote location, the islands remain largely undisturbed by the human activities. Aiming to a first characterization of the entomological diversity and the general trophic niches of atoll's entomofauna, three collects were made (1994, 1995 and 1996) utilizing several methods for a wide sample. One thousand six hundred and six insect specimens were collected belonging to eight orders: 1. Coleoptera - 333 individuals of Dermestidae (Dermestes cadaverinus); Tenebrionidae (Phaleria testacea and morphospecies) and Curculionidae (one morphospecies); 2. Dermaptera - 50 individuals of Carcinophoridae (Anisolabis maritima); 3. Diptera - 281 individuals of Ephydridae (Scatella sp. and Hecamede sp.) and Hippoboscidae (one morphospecies); 4. Hymenoptera - 45 individuals of Formicidae (Brachymyrmex sp.); 5. Lepidoptera - 111 individuals of Microlepidoptera (one morphospecies); 6. Mallophaga - 18 individuals in birds (two morphospecies); 7. Orthoptera - 237 individuals of Acrididae (Schistocerca cancellata), Tridactylidae (one morphospecies) and Blattidae (three morphospecies); 8. Thysanoptera -531 individuals (one morphospecies). Also were collected 112 individuals of Arachnida. The taxa of the Order Araneae were represented by the families: 1. Miturgidae (Cheiracanthium inclusum); 2

  7. Evaluation of corn grain with the genetically modified input trait DAS-59122-7 fed to growing-finishing pigs.

    PubMed

    Stein, H H; Rice, D W; Smith, B L; Hinds, M A; Sauber, T E; Pedersen, C; Wulf, D M; Peters, D N

    2009-04-01

    A growth performance experiment was conducted to assess the feeding value of a double-stacked transgenic corn grain for growing-finishing pigs. The genetically modified corn grain contained event DAS-59122-7, which expresses the Cry34/35Ab1 binary insecticidal protein for the control of corn rootworm. This modified transgenic grain is resistant to western corn rootworm and is also tolerant to herbicides containing the active ingredient glufosinate-ammonium. The modified grain (59122), a nontransgenic near-isoline grain (control corn), and a commercial corn (Pioneer brand hybrid 35P12) were grown in a 2005 production trial in individually isolated plots that were located 201 m apart. A total of 108 pigs were allotted to corn-soybean meal diets containing 1 of the 3 grains as the sole source of corn. There were 3 pigs per pen and 12 replicate pens per treatment. Pigs were fed grower diets from 37 to 60 kg, early finisher diets from 60 to 90 kg, and late finisher diets from 90 to 127 kg. Within each phase, data for ADG, ADFI, and G:F were calculated. At the conclusion of the experiment, pigs were slaughtered and data for carcass quality were collected. Differences between 59122 and the control corn were evaluated, with statistical significance at P<0.05. No differences in ADG, ADFI, or G:F between pigs fed the control corn and pigs fed the modified corn were observed during the grower, early finisher, or late finisher phases. For the entire experimental period, no difference between pigs fed the control and the 59122 corn were observed for final BW (128.9 vs. 127.1 kg), ADG (1.02 vs. 1.00 kg), ADFI (2.88 vs. 2.80 kg), or G:F (0.356 vs. 0.345 kg/kg). Likewise, no differences in dressing percentage (76.48 vs. 76.30%), LM area (49.8 vs. 50.4 cm(2)), 10th-rib back fat (2.20 vs. 2.12 cm), and carcass lean content (52.9 vs. 53.4%) were observed between pigs fed the control and the 59122 corn grain. It was concluded that the nutritional value of the modified transgenic corn

  8. Wood anatomy of Mollinedia glabra (Spreng.) Perkins (Monimiaceae) in two Restinga Vegetation Formations at Rio das Ostras, RJ, Brazil.

    PubMed

    Novaes, Fernanda da S; Callado, Cátia H; Pereira-Moura, Maria Verônica L; Lima, Helena R P

    2010-12-01

    This paper aimed to characterize the anatomical structure of the wood of specimens of Mollinedia glabra (Spreng.) Perkins growing in two contiguous formations of restinga vegetation at Praia Virgem, in the municipality of Rio das Ostras, RJ. Both the Open Palmae (OPS) and the Sandy Strip Closed Shrub (SSCS) formations are found in coastal regions that receive between 1,100 and 1,300 mm of rainfall per year. Sapwood samples were collected in both formations. Typical anatomical features for this species include: solitary vessels, radial multiples or clusters elements, that are circular to angular in outline, 5-15 barred scalariform perforation plates, wood parenchyma scanty, septate fiber-tracheids, and wide multiseriate rays with prismatic crystals. Statistical analyses indicated a significant increase in the frequency of vessel elements and an increase in fiber-tracheid diameters in OPS individuals. These characteristics are considered structural adaptations to increased water needs caused by a greater exposure to sunlight. Continuous pruning may be responsible for the tyloses observed in OPS plants. The greater lengths and higher frequencies of the rays in SSCS trees may be due to the greater diameters of their branches. Our results suggest that M. glabra develops structural adaptations to the restinga micro-environmental variations during its development.

  9. Von neuen Geschäftsideen zur gelebten Digitalisierung in Utility 4.0 - das Integrierte Geschäftsmodell

    NASA Astrophysics Data System (ADS)

    Doleski, Oliver D.

    Die Energiewirtschaft benötigt neue, digitale Geschäftsmodelle. Gegenwärtig folgt auf Liberalisierung und Energiewende die nächste Stufe einer weitreichenden Bereinigung des Versorgungsmarktes. Digitalisierung und Dezentralisierung sind heute in aller Munde und verlangen nach neuen Produkten und Dienstleistungen. Dabei wirken die immensen Herausforderungen einer digitalen Energiewelt wie Beschleuniger für die Transformation im Versorgungssektor und tragen damit zur breiten Etablierung von Utilities 4.0 bei. Dieser Entwicklungsprozess vollzieht sich mithilfe unterschiedlicher Methoden zur Realisierung neuer Geschäftsideen. Allerdings greifen die gängigen Konzepte zur Entwicklung von Geschäftsmodellen gerade im Hinblick auf die Berücksichtigung komplexer, unbeständiger Rahmenbedingungen und spezifischer Anforderungen der digitalen Energiewelt mitunter zu kurz. Vor diesem Hintergrund wird das auf dem ganzheitlichen St. Galler Management-Konzept beruhende Integrierte Geschäftsmodell iOcTen als geeignetes Instrumentarium zur Geschäftsmodellentwicklung vorgestellt. Neben der Modellbeschreibung unterstützt ein intuitiv verständlicher Leitfaden den Praktiker bei der Transformation vom klassischen Versorgungsunternehmen zum digitalen Energiedienstleistungsunternehmen.

  10. Das Lektin aus der Erbse Pisum sativum : Bindungsstudien, Monomer-Dimer-Gleichgewicht und Rückfaltung aus Fragmenten

    NASA Astrophysics Data System (ADS)

    Küster, Frank

    2002-11-01

    Das Lektin aus Pisum sativum, der Gartenerbse, ist Teil der Familie der Leguminosenlektine. Diese Proteine haben untereinander eine hohe Sequenzhomologie, und die Struktur ihrer Monomere, ein all-ß-Motiv, ist hoch konserviert. Dagegen gibt es innerhalb der Familie eine große Vielfalt an unterschiedlichen Quartärstrukturen, die Gegenstand kristallographischer und theoretischer Arbeiten waren. Das Erbsenlektin ist ein dimeres Leguminosenlektin mit einer Besonderheit in seiner Struktur: Nach der Faltung in der Zelle wird aus einem Loop eine kurze Aminosäuresequenz herausgeschnitten, so dass sich in jeder Untereinheit zwei unabhängige Polypeptidketten befinden. Beide Ketten sind aber stark miteinander verschränkt und bilden eine gemeinsame strukturelle Domäne. Wie alle Lektine bindet Erbsenlektin komplexe Oligosaccharide, doch sind seine physiologische Rolle und der natürliche Ligand unbekannt. In dieser Arbeit wurden Versuche zur Entwicklung eines Funktionstests für Erbsenlektin durchgeführt und seine Faltung, Stabilität und Monomer-Dimer-Gleichgewicht charakterisiert. Um die spezifische Rolle der Prozessierung für Stabilität und Faltung zu untersuchen, wurde ein unprozessiertes Konstrukt in E. coli exprimiert und mit der prozessierten Form verglichen. Beide Proteine zeigen die gleiche kinetische Stabilität gegenüber chemischer Denaturierung. Sie denaturieren extrem langsam, weil nur die isolierten Untereinheiten entfalten können und das Monomer-Dimer-Gleichgewicht bei mittleren Konzentrationen an Denaturierungsmittel auf der Seite der Dimere liegt. Durch die extrem langsame Entfaltung zeigen beide Proteine eine apparente Hysterese im Gleichgewichtsübergang, und es ist nicht möglich, die thermodynamische Stabilität zu bestimmen. Die Stabilität und die Geschwindigkeit der Assoziation und Dissoziation in die prozessierten bzw. nichtprozessierten Untereinheiten sind für beide Proteine gleich. Darüber hinaus konnte gezeigt werden, dass auch unter

  11. Free convection in a parallelogrammic porous cavity filled with a nanofluid using Tiwari and Das' nanofluid model.

    PubMed

    Ghalambaz, Mohammad; Sheremet, Mikhail A; Pop, Ioan

    2015-01-01

    The free convection heat transfer of Cu-water nanofluids in a parallelogrammic enclosure filled with porous media is numerically analyzed. The bottom and top of the enclosure are insulated while the sidewalls are subject to limited temperature difference. The Darcy flow and the Tiwari and Das' nanofluid models are considered. The governing dimensionless partial differential equations are numerically solved using a finite difference code. The results are reported for isotherms and streamlines as well as Nusselt number as a function of the volume fraction of nanoparticles, porosity, types of the porous matrix, inclination angle, aspect ratio and different Rayleigh numbers. It is found that the presence of the nanoparticles inside the enclosure deteriorates the heat transfer rate, which is caused due to the increase of dynamic viscosity by the presence of nanoparticles. Therefore, in applications in which the nanofluids are used for their advantages, such as enhanced dielectric properties or antibacterial properties, more caution for the heat transfer design of the enclosure is necessary.

  12. Nutrient budgets (C, N and P) and trophic dynamics of a Brazilian tropical estuary: Barra das Jangadas.

    PubMed

    Noriega, Carlos E D; Araujo, Moacyr

    2011-06-01

    This paper focuses on the nutrient dynamics of a tropical estuary on the northeastern Brazilian coast, studied using the LOICZ biogeochemical budgeting protocol. We describe the methodology and assumptions underlying this model. Input data (monthly for rainfall, evaporation, river discharge, and concentrations of salt, phosphorus and nitrogen) were obtained during field campaigns in the Barra das Jangadas Estuary (BJE) over a 5 years period (1999 to 2003). Mass balance results indicate large inputs of nutrients to the system. The model shows that the seasonal variation of the Net Ecosystem Metabolism (NEM) indicates that the system passes from a stage of organic matter liquid production and mineralization during the dry season (-0.5 mmoles C m(-2) d(-1)) to liquid mineralization during the rainy season (-19 mmoles C m(-2) d(-1)). We suggest that the system varies slightly between autotrophy and heterotrophy during the year due to the rainfall regime, human activities in the basin (density population and sugarcane plantations), and associated DIP riverine loads. High per capita loads of N and P indicate a high population density and high runoff. The application of flux balance modeling was useful to understand the nutrient dynamics of this typical small tropical estuary.

  13. Stacking transgenic event DAS-Ø15Ø7-1 alters maize composition less than traditional breeding.

    PubMed

    Herman, Rod A; Fast, Brandon J; Scherer, Peter N; Brune, Alyssa M; de Cerqueira, Denise T; Schafer, Barry W; Ekmay, Ricardo D; Harrigan, George G; Bradfisch, Greg A

    2017-10-01

    The impact of crossing ('stacking') genetically modified (GM) events on maize-grain biochemical composition was compared with the impact of generating nonGM hybrids. The compositional similarity of seven GM stacks containing event DAS-Ø15Ø7-1, and their matched nonGM near-isogenic hybrids (iso-hybrids) was compared with the compositional similarity of concurrently grown nonGM hybrids and these same iso-hybrids. Scatter plots were used to visualize comparisons among hybrids and a coefficient of identity (per cent of variation explained by line of identity) was calculated to quantify the relationships within analyte profiles. The composition of GM breeding stacks was more similar to the composition of iso-hybrids than was the composition of nonGM hybrids. NonGM breeding more strongly influenced crop composition than did transgenesis or stacking of GM events. These findings call into question the value of uniquely requiring composition studies for GM crops, especially for breeding stacks composed of GM events previously found to be compositionally normal. © 2017 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  14. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities - A General Overview

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.; Hughes, Mark S.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Marshall, PeggL.; Duncan, Michael E.; Morris, Jon A.; Franzl, Richard W.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition system (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis' development and deployment.

  15. Acute postsurgical suppurative parotitis: current prevalence at Hospital das Clínicas, São Paulo University Medical School.

    PubMed

    Belczak, Sergio Quilici; Cleva, Roberto D E; Utiyama, Edivaldo M; Cecconello, Ivan; Rasslan, Samir; Parreira, José Gustavo

    2008-01-01

    Postsurgical acute suppurative parotitis is a bacterial gland infection that occurs from a few days up to some weeks after abdominal surgical procedures. In this study, the authors analyze the prevalence of this complication in Hospital das Clínicas/São Paulo University Medical School by prospectively reviewing the charts of patients who underwent surgeries performed by the gastroenterological and general surgery staff from 1980 to 2005. Diagnosis of parotitis or sialoadenitis was analyzed. Sialolithiasis and chronic parotitis previous to hospitalization were exclusion criteria. In a total of 100,679 surgeries, 256 patients were diagnosed with parotitis or sialoadenitis. Nevertheless, only three cases of acute postsurgical suppurative parotitis associated with the surgery were identified giving an incidence of 0.0028%. All patients presented with risk factors such as malnutrition, immunosuppression, prolonged immobilization and dehydration. In the past, acute postsurgical suppurative parotitis was a relatively common complication after major abdominal surgeries. Its incidence decreased as a consequence of the improvement of perioperative antibiotic therapy and postoperative support. In spite of the current low incidence, we believe it is important to identify risks and diagnose as quick as possible, in order to introduce prompt and appropriate therapeutic measures and avoid potentially fatal complications with the evolution of the disease.

  16. Astronomy Teaching and Teachers Continuing Education: the Interdisciplinarity during a Total Lunar Eclipse. (Spanish Title: Enseñanza de la Astronomía y la Formación Continua de Profesores: la Interdisciplinariedad Durante un Eclipse Total de Luna.) Educação EM Astronomia E Formação Continuada de Professores: a Interdisciplinaridade Durante um Eclipse Lunar TOTAL

    NASA Astrophysics Data System (ADS)

    Langhi, Rodolfo

    2009-07-01

    This paper describes how 67 teachers from 23 cities, could awaken, in students, the scientific interest, using a natural astronomical phenomenon: a total lunar eclipse. Before and after of eclipse, meetings for continuing education were characterized by interdisciplinarity of astronomy and the importance of these observations. Working groups were formed by teachers and students, who organized the survey data, mobilizing the people in their cities. The results point ways about how to provide the scientific culture and the motivation to learn science in students, using approaches between the following communities: scientific, amateur and school. En este artículo se describe cómo 67 profesores de 23 ciudades, despertó el interés científico en los estudiantes mediante un fenómeno astronómico: un eclipse total de Luna. Antes y después del eclipse, reuniones para la formación continua se centraron en la interdisciplinariedad de la astronomía, y la importancia de las observaciones de este tipo de fenómeno. Profesores y estudiantes formaron grupos de trabajo para investigar datos durante el eclipse, con el participación de la comunidad en sus ciudades. Los resultados apuntan a las opciones que conducen a la cultura científica y la motivación para aprender la ciencia, utilizando las relaciones de los siguientes grupos: científicos, aficionados y la escuela. Este texto relata como 67 professores, provenientes de 23 cidades, puderam despertar, nos alunos, o interesse científico utilizando um fenômeno natural astronômico: um eclipse lunar total. O evento foi precedido e procedido por encontros de formação continuada, onde se caracterizou a interdisciplinaridade da astronomia e a importância das observações de fenômenos como estes. Grupos de trabalho foram formados por professores e alunos, que se organizaram para o levantamento conjunto de dados durante o fenômeno, além do envolvimento da comunidade em suas respectivas cidades. Os resultados apontam

  17. Variation of the anthropic vulnerability in Ribeirão das Pedras watershed in Campinas/SP - Brazil.

    NASA Astrophysics Data System (ADS)

    Damame, Desirée; Longo, Regina; Ribeiro, Admilson; Fengler, Felipe

    2015-04-01

    The human actions has caused over the years profound changes in environmental quality in urban ecosystems suffering losses in the quality of air, soil , water and vegetation also the quality of life of the population that inhabit these areas . The study area is characterized by being a highly urbanized watershed, with about 43 % of its area covered by buildings, houses , and commercial and industrial establishments . Called the Ribeirão das Pedras Basin, located in Campinas / SP - Brazil and is bounded by coordinates 22˚47'10 '' and 22˚52'20 '' S , and 47˚ 07'15 '' and 46˚ 02 ' 15' ' . Has an average temperature of 22.4 ° C and average annual rainfall of 1424.5 mm . It has an area of about 42 km² . This is located two universities and a large mall. It also demands a strong agriculture , which occupies about 30 % of the area . It has also been part of two major forest reserves of the municipality, the Forest Santa Geneva and the Forest of Quilombo , both added to other small fragments overlying only about 6% of the total basin area . Avalição to environmental quality , the analysis of the vulnerability of urban watershed becomes an important environmental management tool. The vulnerability can be defined by susceptibility to changes of environment in its initial state , a current tax status by human intervention , and is almost always associated with risk , and the intensity at which such projects in one place, person or structure. In this context , this study aimed to assess environmental vulnerability in an urban watershed coming under increasing human pressures , especially in recent years . For this analysis were prepared soil graphics, slope , elevation and land use and land cover for the years 2009 and 2014 , generating with these , comparative anthropic vulnerability maps of the past five years. Crafting vulnerability maps is a sensitivity in order to enable appropriate management of biotic systems. With the results can be seen that the variation of

  18. Bottom Characterization with High Resolution Sonar Data and Geochemical Analyses of an Uninvestigated Cone in Lagoa das Furnas on São Miguel Island, Azores Archipelago

    NASA Astrophysics Data System (ADS)

    Andersson, T.

    2015-12-01

    Lagoa das Furnas is a crater lake located in an area exposed to geohazards from earthquakes and volcanic activity on the island São Miguel in the Azores Archipelago. The Furnas volcanic center has a long history of earthquakes and volcanic activity. The area is relatively well studied except for the lake floor. Therefore, a high resolution geophysical and geological mapping survey was conducted at Lagoa das Furnas. Sidescan sonar was used to map the surface of the lake floor and single beam sonar was used to acquire sub-bottom profiles. In addition to the geophysical mapping, sediment surface sampling and core drilling were carried out followed by geochemical analyses of the retrieved material. The mapped data permitted a characterization of the floor of Lagoa das Furnas and revealed several volcanic features including fumarolic activity and a previously uninvestigated volcanic cone in the southern part of the lake. In order to unravel the origin of this cone several methods were applied, including analyses of tephra and minerals collected from the cone itself and from nearby deposits of two known eruptions, Furnas I and Furnas 1630. Sedimentological, petrological, geochemical and geochronological studies of pyroclastic deposits from the cone suggest a subaqueous eruption linked to the Furnas 1630 eruption. The chemistry of glass and crystal fragments sampled from the cone suggests that it is composed of more evolved magma than that of the main Furnas 1630, implying that the lake cone is likely a product of the last eruptional phase. According to historical records, two of three lakes were lost due the Furnas 1630 eruption. The results of this study show that the remaining lake is most likely Lagoa das Furnas, which consequently must have existed before the 1630 eruption.

  19. Comparative morphology of the reproductive system of seven species of ostariophysan fishes from the upper Das Velhas River, Brazil.

    PubMed

    Melo, Rafael Magno Costa; Gomes, Débora Diniz; Moreira, Davidson Peruci; Gomes, Maysa Regina; Bazzoli, Nilo; Rizzo, Elizete

    2017-02-01

    The success of fishes in different environments is related with the variation of reproductive strategies developed by the systematic group, which is reflected in the morphology of the reproductive system and can have ecological and evolutionary implications. This study comparatively analyzed the morphological characteristics of the male and female reproductive systems of ostariophysan fish species from the upper Das Velhas River in the São Francisco River basin, Brazil. In order to accomplish this, 393 specimens belonging to seven fish species were sampled between April 2010 and June 2015 for histological, ultrastructural, histochemical, and morphometric analyses. All the species examined have anastomosing tubular testes with unrestricted distribution of spermatogonia. Astyanax bimaculatus, A. fasciatus, A. scabripinnis, and Harttia torrenticola had their spermatozoa embedded in a glycoprotein secretion within the tubule lumen. Most species had type I spermiogenesis, whereas Rhamdia quelen had type III spermiogenesis. While all females examined had asynchronous oocyte development, there were remarkable morphological, histochemical, and morphometric differences in the ovarian follicles and enveloping layers. Hoplias malabaricus and H. torrenticola, which exhibit parental care behaviour, had a significantly larger diameter of vitellogenic oocytes and larger spermatozoa nuclei. Apareiodon ibitiensis, H. torrenticola, and A. scabripinnis, species that have rheophilic preferences, exhibited a thicker zona radiata than the other species examined. The follicular cells of R. quelen and H. torrenticola were columnar and produced a jelly coat and mucosubstances, respectively. The females of the seven fish species studied show a correlation of the reproductive strategies with the reproductive system morphology, while males retained more similar morphological characteristics between species. J. Morphol. 278:170-181, 2017. © 2016 Wiley Periodicals,Inc. © 2016 Wiley

  20. Ventos em supergigantes B[e] das nuvens de Magalhães e da Galáxia

    NASA Astrophysics Data System (ADS)

    de Araújo, F. X.; Pilling, D. A.; Pereira, C. B.; Fernandes, M. B.

    2003-08-01

    As Supergigantes B[e] apresentam as seguintes características: (i) alta luminosidade; (ii) espectro típico de estrelas de tipo B; (iii) linhas permitidas e proibidas em emissão de metais de baixa ionização, especialmente FeII; (iv) linhas de Balmer, e por vêzes também dos ions HeI e FeII, com perfis tipo P Cygni indicativos de altas taxas de perda de massa. Atualmente estamos desenvolvendo um projeto que visa comparar as propriedades fisicas (principalmente e v¥) dos ventos destes objetos nas Nuvens de Magalhães e na Galaxia. O objetivo é estudar a influência da metalicidade. No presente painel apresentamos uma determinação das velocidades terminais de 11 estrelas, sendo 4 na GNM (Hen S111, 66, R126 e Hen S93), 4 na PNM (Hen S18, S23, S65 e R4) e 3 na Galaxia (CPD-529243, MWC 300 e GG Car). Nossos dados são espectros de alta resolução obtidos no telescópio 1.52m do ESO com o espectrógrafo FEROS. Para determinar as velocidades terminais usamos as linhas Hd e HeI 3888 Å cujas componentes em absorção costumam estar livres de "blends" e estruturas. Nossos resultados sugerem que as velocidades de expansão na GNM são maiores (ainda que apenas ligeiramente) do que aquelas da PNM, como esperado. No entanto, os objetos da Galaxia não parecem seguir a mesma tendência.

  1. Das wissenschaftliche Handbuch

    NASA Astrophysics Data System (ADS)

    Luckenbach, Reiner; Sunkel, Josef

    1981-02-01

    The 100th anniversary of Beilstein's Handbook of Organic Chemistry, founded in 1881, merits a brief description of the principal concepts and goals of the literary genre “scientific handbook” in general. Systematic arrangement, critical data and fact evaluation, thoroughness and reliability are among these goals, thus providing the handbook user with a concise compilation of carefully checked and cross-referenced information in his particular field of interest.

  2. Desenvolvimento das câmeras de raios-X duros do satélite MIRAX

    NASA Astrophysics Data System (ADS)

    Braga, J.; Rothschild, R.; Staubert, R.; Heise, J.; Remillard, R.; D'Amico, F.; Jablonski, F.; Mejía, J.; Carvalho, H.; Heindl, B.; Matteson, J.; Kendziorra, E.; Wilms, J.; in't Zand, J.; Kuulkers, E.

    2003-08-01

    O MIRAX (Monitor e Imageador de RAios-X) é um projeto de desenvolvimento de um pequeno satélite astronômico de raios-X (~200 kg, ~240 W). A estratégia básica da missão será observar continuamente (~9 meses por ano) a região central (~1000 graus2) do plano Galáctico e realizar estudos espectroscópicos de banda larga (2-200 keV) e alta sensibilidade de um grande conjunto de fontes através de imagens com resolução de ~6'. Isso proporcionará uma cobertura inédita do "espaço de descobertas" através da detecção, localização, identificação e estudo detalhado de fenômenos imprevisíveis, tais como transientes fracos de raios-X, novas rápidas de raios-X e bursts de raios gama, assim como o estudo de fontes com emissão persistente. Neste trabalho apresentamos o projeto das duas câmeras de raios-X duros (CXDs) do MIRAX, que irão operar na faixa de 10 a 200 keV. Cada CXD consistirá de um plano de detectores CZT (Cd0,9Zn0,1Te) de 0,5 mm de resolução espacial e 370 cm2 de área total, e de uma máscara codificada com elementos quadrados de 1,3 mm de lado e 0,5 cm de espessura. A máscara terá dimensões de 315 cm ´ 275 cm e será montada a 700 cm de distância dos detectores. Com essa configuração as CXDs terão 6' de resolução angular e, quando colocadas a um ângulo de 29° entre si, as duas câmeras propiciam um campo totalmente codificado de 39° ´ 6°12' e um campo total de 76° ´ 44°. Serão apresentadas simulações de observações da região do plano Galáctico com o conjunto formado pelas duas CXDs.

  3. Soil gas Rn monitoring at Chã das Caldeiras prior the 2014-15 Fogo eruption, Cape Verde

    NASA Astrophysics Data System (ADS)

    Padilla, Germán; Barrancos, José; Dionis, Samara; Fernandes, Paulo; Pérez, Nemesio M.; Sagiya, Takeshi; Padrón, Eleazar; Melián, Gladys V.; Hernández, Pedro A.; Silva, Sónia; Pereira, José Manuel; Rodríguez, Fátima; Asensio-Ramos, María; Calvo, David; Semedo, Helio

    2015-04-01

    Since 2007 the ITER-INVOLCAN/UNICV-OVCV/SNPC research team has implemented a geochemical program for the volcanic surveillance of Fogo volcano by means of applying different geochemical methods in a regularly basis (diffuse degassing surveys, fumarole gas sampling, etc.). This program was improved by setting up a geochemical permanent station (CHA01) to perform continuous measurements of soil gas radon (222Rn) and thoron (220Rn) activities at Chã das Caldeiras, more specific in Portela village, since April 20, 2013. Both gases are characterized to ascend towards the surface mainly through cracks or faults via diffusion and/or advection mechanisms dependent of both soil porosity and permeability, which in turn vary as a function of the stress/strain changes at depth. Measurements of 222Rn and 220Rn activities were performed by an alpha-spectrometer after pumping the soil gas from a thermally isolated PVC pipe inserted 1m in the ground. Even though during the study period the recorded data did not show high 222Rn activity values, a change in the temporal evolution of soil gas 222Rn activity was observed. During the first six months, from April to October, 2013, recorded time series of 222Rn and 220Rn activities showed normal background levels with values of 80.5 and 55.2 Bqm-3, respectively. However, from October, 2013, to February, 2014, 222Rn time series showed an increase trend reaching peak values of 396 Bqm-3 and having an average activity of 134 Bqm-3 until the removal of the station on November 25, 2014 due to the potential danger of being destroyed by the lava flows. The observed increase in the soil gas 222Rn activity from October 2013 to February 2014 occurs almost at the same time of slight observed changes in the vertical displacements detected by the geodetic network installed at the Fogo Island by the ITER-INVOLCAN/UNICV-OVCV/SNPC/Nagoya University research team. Since seismic data are not available, we cannot conclude if the observed changes in soil

  4. Geochemistry of komatiites and basalts from the Rio das Velhas and Pitangui greenstone belts, São Francisco Craton, Brazil: Implications for the origin, evolution, and tectonic setting

    NASA Astrophysics Data System (ADS)

    Verma, Sanjeet K.; Oliveira, Elson P.; Silva, Paola M.; Moreno, Juan A.; Amaral, Wagner S.

    2017-07-01

    The Neoarchean Rio das Velhas and Pitangui greenstone belts are situated in the southern São Francisco Craton, Minas Gerais, Brazil. These greenstone belts were formed between ca. 2.79-2.73 Ga, and consist mostly of mafic to ultramafic volcanics and clastic sediments, with minor chemical sediments and felsic volcanics that were metamorphosed under greenschist facies. Komatiites are found only in the Rio das Velhas greenstone belt, which is composed of high-MgO volcanic rocks that have been identified as komatiites and high-Mg basalts, based on their distinctive geochemical characteristics. The Rio das Velhas komatiites are composed of tremolite + actinolite + serpentine + albite with a relict spinifex-texture. The Rio das Velhas komatiites have a high magnesium content ((MgO)adj ≥ 28 wt.%), an Al-undepleted Munro-type [(Al2O3/TiO2)adj and (CaO/Al2O3)adj] ratio ranging from 27 to 47 and 0.48 to 0.89, relatively low abundances of incompatible elements, a depletion of light rare earth elements (LREE), a pattern of non-fractionated heavy rare- earth elements (HREE), and a low (Gd/Yb)PM ratio (≤ 1.0). Negative Ce anomalies suggest that alteration occurred during greenschist facies metamorphism for the komatiites and high-Mg basalts. The low [(Gd/Yb)PM < 1.0] and [(CaO/Al2O3)adj < 0.9)], high [(Al2O3/TiO2)adj > 18] and high HREE, Y, and Zr content suggest that the Rio das Velhas komatiites were derived from the shallow upper mantle without garnet involvement in the residue. The chemical compositions [(Al2O3/TiO2)adj, (FeO)adj, (MgO)adj, (CaO/Al2O3)adj, Na, Th, Ta, Ni, Cr, Zr, Y, Hf, and REE] indicate that the formation of the komatiites, high-Mg basalts and basalts occurred at different depths and temperatures in a heterogeneous mantle. The komatiites and high-Mg basalts melted at liquidus temperatures of 1450-1550 °C. The Pitangui basalts are enriched in the highly incompatible LILE (large-ion lithophile elements) relative to the moderately incompatible HFS (high

  5. Challenges for bathing in rivers in terms of compliance with coliform standards. Case study in a large urbanized basin (das Velhas River, Brazil).

    PubMed

    von Sperling, Marcos; von Sperling, Eduardo

    2013-01-01

    This paper presents a case study on the prospects of bathing in a large water course (das Velhas River, Brazil), which crosses the important metropolitan region of Belo Horizonte (25 municipalities), receiving several point and diffuse discharges. The studies were carried out based on a mathematical simulation of thermotolerant coliforms over 227 km of the river, using an adaptation of the Qual2E model (model Qual-UFMG). Simulations of intervention scenarios were made for the current conditions, with three reference flows for the das Velhas River, tributaries and direct contribution: Q7,10 (representative of low-flow conditions), Q50 (average conditions) and Q10 (rainy season). The intervention scenarios simulated were: (a) current conditions without intervention; (b) scenario with effluent disinfection in the two largest wastewater treatment plants in the basin (around 2.4 million inhabitants); (c) scenario with 95% sewage collection and treatment, with disinfection in all municipalities of the study area; (d) scenario with the calculation of values required for the coverage of sewage treatment and coliform removal efficiencies based on a mathematical optimization process. The monitoring data and results of all simulations indicated improvement in coliform concentration as the river flows downstream. However, results suggested that disinfection per se is not enough. Even under hypothetical conditions of excellent sanitary infrastructure for a developing country, coverage of collection and treatment of 95% of the generated sewage, and treatment with disinfection at all wastewater treatment plants, concentrations of thermotolerant coliforms in das Velhas River are likely to be above the maximum allowable of 1,000 MPN/100 mL for bathing purposes. The mathematical optimization indicated the need for very high percentages of sewage treatment coverage (near 100%, i.e. universality of collection and treatment) and implementation of disinfection in most treatment plants

  6. Data Integration Acquired from Micro-Uav and Terrestrial Laser Scanner for the 3d Mapping of Jesuit Ruins of São Miguel das Missões

    NASA Astrophysics Data System (ADS)

    Reiss, M. L. L.; da Rocha, R. S.; Ferraz, R. S.; Cruz, V. C.; Morador, L. Q.; Yamawaki, M. K.; Rodrigues, E. L. S.; Cole, J. O.; Mezzomo, W.

    2016-06-01

    The Jesuit Missions the Guaranis were one of the great examples of cultural, social, and scientific of the eighteenth century, which had its decline from successive wars that followed the exchange of territories domain occupied by Portugal and Spain with the Madrid Treaty of January 13, 1750. One of the great examples of this development is materialized in the ruins of 30 churches and villages that remain in a territory that now comprises part of Brazil, Argentina and Paraguay. These Churches, São Miguel das Missões is among the Brazilian ruins, the best preserved. The ruins of São Miguel das Missões were declared a UNESCO World Cultural Heritage in 1983 and the Institute of National Historical Heritage (IPHAN) is the Brazilian Federal agency that manages and maintains this heritage. In order to produce a geographic database to assist the IPHAN in the management of the Ruins of São Miguel das Missões it was proposed a three-dimensional mapping of these ruins never performed in this location before. The proposal is integrated data acquired from multiple sensors: two micro-UAV, an Asctec Falcon 8 (rotary wing) and a Sensefly e-Bee (fixed wing); photos from terrestrial cameras; two terrestrial LIDAR sensors, one Faro Focus 3D S-120 and Optec 3D-HD ILRIS. With this abundance of sensors has been possible to perform comparisons and integration of the acquired data, and produce a 3D reconstruction of the church with high completeness and accuracy (better than 25 mm), as can be seen in the presentation of this work.

  7. Seismic Monitoring of Permafrost During Controlled Thaw: An Active-Source Experiment Using a Surface Orbital Vibrator and Fiber-Optic DAS Arrays

    NASA Astrophysics Data System (ADS)

    Dou, S.; Wood, T.; Lindsey, N.; Ajo Franklin, J. B.; Freifeld, B. M.; Gelvin, A.; Morales, A.; Saari, S.; Ekblaw, I.; Wagner, A. M.; Daley, T. M.; Robertson, M.; Martin, E. R.; Ulrich, C.; Bjella, K.

    2016-12-01

    Thawing of permafrost can cause ground deformations that threaten the integrity of civil infrastructure. It is essential to develop early warning systems that can identify critically warmed permafrost and issue warnings for hazard prevention and control. Seismic methods can play a pivotal role in such systems for at least two reasons: First, seismic velocities are indicative of mechanical strength of the subsurface and thus are directly relevant to engineering properties; Second, seismic velocities in permafrost systems are sensitive to pre-thaw warming, which makes it possible to issue early warnings before the occurrence of hazardous subsidence events. However, several questions remain: What are the seismic signatures that can be effectively used for early warning of permafrost thaw? Can seismic methods provide enough warning times for hazard prevention and control? In this study, we investigate the feasibility of using permanently installed seismic networks for early warnings of permafrost thaw. We conducted continuous active-source seismic monitoring of permafrost that was under controlled heating at CRREL's Fairbanks permafrost experiment station. We used a permanently installed surface orbital vibrator (SOV) as source and surface-trenched DAS arrays as receivers. The SOV is characterized by its excellent repeatability, automated operation, high energy level, and the rich frequency content (10-100 Hz) of the generated wavefields. The fiber-optic DAS arrays allow continuous recording of seismic data with dense spatial sampling (1-meter channel spacing), low cost, and low maintenance. This combination of SOV-DAS provides unique seismic datasets for observing time-lapse changes of warming permafrost at the field scale, hence providing an observational basis for design and development of early warning systems for permafrost thaw.

  8. ACR/EULAR Definitions of Remission Are Associated with Lower Residual Inflammatory Activity Compared with DAS28 Remission on Hand MRI in Rheumatoid Arthritis.

    PubMed

    Lisbona, Maria Pilar; Solano, Albert; Ares, Jesús; Almirall, Miriam; Salman-Monte, Tarek Carlos; Maymó, Joan

    2016-09-01

    To determine the level of residual inflammation [synovitis, bone marrow edema (BME), tenosynovitis, and total inflammation] quantified by hand magnetic resonance imaging (h-MRI) in patients with rheumatoid arthritis (RA) in remission according to 3 different definitions of clinical remission, and to compare these remission definitions. A cross-sectional study. To assess the level of residual MRI inflammation in remission, cutoff levels associated to remission and median scores of MRI residual inflammatory lesions were calculated. Data from an MRI register of patients with RA who have various levels of disease activity were used. These were used for the analyses: synovitis, BME according to the Rheumatoid Arthritis Magnetic Resonance Imaging Scoring system, tenosynovitis, total inflammation, and disease activity composite measures recorded at the time of MRI. Receiver-operating characteristic analysis was used to identify the best cutoffs associated with remission for each inflammatory lesion on h-MRI. Median values of each inflammatory lesion for each definition of remission were also calculated. A total of 388 h-MRI sets of patients with RA with different levels of disease activity, 130 in remission, were included. Cutoff values associated with remission according to the Simplified Disease Activity Index (SDAI) ≤ 3.3 and the Boolean American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) definitions for BME and tenosynovitis (1 and 3, respectively) were lower than BME and tenosynovitis (2 and 5, respectively) for the Disease Activity Score on 28 joints (DAS28) ≤ 2.6. Median scores for synovitis, BME, and total inflammation were also lower for the SDAI and Boolean ACR/EULAR remission criteria compared with DAS28. Patients with RA in remission according to the SDAI and Boolean ACR/EULAR definitions showed lower levels of MRI-detected residual inflammation compared with DAS28.

  9. Comment on the use of self-reporting instruments to assess patients with rheumatoid arthritis: the longitudinal association between the DAS28 and the VAS general health.

    PubMed

    Kievit, W; Welsing, P M J; Adang, E M M; Eijsbouts, A M; Krabbe, P F M; van Riel, P L C M

    2006-10-15

    Recently, the use of patient self-reporting instruments instead of clinical, objective measurements to assess rheumatoid arthritis (RA) patients was proposed. This assumes a constant association between disease activity and the self-reporting instruments. The objective was to explore the association (in time) between disease activity and patient perception of general health, disease activity, pain, and functional disability in patients with RA. Data of 624 newly diagnosed RA patients who completed 3 years of followup were analyzed. Cross-sectional linear regression models and longitudinal regression models were estimated, with a visual analog scale (VAS) measuring general health (VAS-GH; 0 = best, 100 = worst) as a dependent variable and the Disease Activity Score (DAS28) without the VAS-GH as an independent variable. Other dependent variables were VAS disease activity, pain, and the Health Assessment Questionnaire. The DAS28 and VAS-GH were significantly associated in RA patients (P < 0.001). However, the explained variance was low (6.7%). From diagnosis to 3 years after the diagnosis, the intercept decreased given the same regression coefficient. The longitudinal regression model showed that the VAS-GH improved during disease course independent of a change in DAS28. Analyses on the other outcome parameters showed similar results. Patients' perception of health can be different with equal disease activity, depending on the moment in the disease course. Furthermore, our results indicate that self-reported measures on functionality, disease activity, and general health cannot substitute for objective measures of disease activity in RA in longitudinal studies; subsequently, both need to be measured.

  10. [Spanish version of the new World Health Organization Disability Assessment Schedule II (WHO-DAS-II): initial phase of development and pilot study. Cantabria disability work group].

    PubMed

    Vázquez-Barquero, J L; Vázquez Bourgón, E; Herrera Castanedo, S; Saiz, J; Uriarte, M; Morales, F; Gaite, L; Herrán, A; Ustün, T B

    2000-01-01

    The aim of the present paper is to present the initial phases of the development of the Spanish version of the "World Health Organization Disablement Assessment Schedule II" WHO-DAS-II and also to describe the quantitative and qualitative methodological strategies used in the elaboration process of an instrument: i) compatible with the new International Classification of Functioning and Disability -ICIDH-2- of the World Health Organisation; ii) with criteria of cross-cultural applicability and; iii) to allow us to assess the disability in all its dimensions.

  11. DasPy 1.0 - the Open Source Multivariate Land Data Assimilation Framework in combination with the Community Land Model 4.5

    NASA Astrophysics Data System (ADS)

    Han, X.; Li, X.; He, G.; Kumbhar, P.; Montzka, C.; Kollet, S.; Miyoshi, T.; Rosolem, R.; Zhang, Y.; Vereecken, H.; Franssen, H.-J. H.

    2015-08-01

    Data assimilation has become a popular method to integrate observations from multiple sources with land surface models to improve predictions of the water and energy cycles of the soil-vegetation-atmosphere continuum. Multivariate data assimilation refers to the simultaneous assimilation of observation data from multiple model state variables into a simulation model. In recent years, several land data assimilation systems have been developed in different research agencies. Because of the software availability or adaptability, these systems are not easy to apply for the purpose of multivariate land data assimilation research. We developed an open source multivariate land data assimilation framework (DasPy) which is implemented using the Python script language mixed with the C++ and Fortran programming languages. LETKF (Local Ensemble Transform Kalman Filter) is implemented as the main data assimilation algorithm, and uncertainties in the data assimilation can be introduced by perturbed atmospheric forcing data, and represented by perturbed soil and vegetation parameters and model initial conditions. The Community Land Model (CLM) was integrated as the model operator. The implementation allows also parameter estimation (soil properties and/or leaf area index) on the basis of the joint state and parameter estimation approach. The Community Microwave Emission Modelling platform (CMEM), COsmic-ray Soil Moisture Interaction Code (COSMIC) and the Two-Source Formulation (TSF) were integrated as observation operators for the assimilation of L-band passive microwave, cosmic-ray soil moisture probe and land surface temperature measurements, respectively. DasPy has been evaluated in several assimilation studies of neutron count intensity (soil moisture), L-band brightness temperature and land surface temperature. DasPy is parallelized using the hybrid Message Passing Interface and Open Multi-Processing techniques. All the input and output data flows are organized efficiently

  12. Agronomic performance of insect-protected and herbicide-tolerant MON 89034 × TC1507 × NK603 × DAS-40278-9 corn is equivalent to that of conventional corn.

    PubMed

    Cerqueira, Denise T Rezende de; Schafer, Ariane C; Fast, Brandon J; Herman, Rod A

    2017-03-31

    Agronomic characteristics of genetically modified (GM) MON 89034 × TC1507 × NK603 × DAS-40278-9 (PowerCore™ Enlist™), MON 89034 × TC1507 × NK603 (PowerCore™), and DAS-40278-9 (Enlist™) corn, a non-GM near-isogenic hybrid, and two commercial non-GM hybrids were assessed in a field study to determine if the agronomic performance of the GM corn hybrids is equivalent to that of non-transgenic hybrid corn. The MON 89034 × TC1507 × NK603 × DAS-40278-9 hybrid corn was developed through stacking of four individual transgenic events, MON 89034, TC1507, NK603, and DAS-40278-9 by traditional breeding and contains the cry1A.105 and cry2Ab2 (MON 89034), cry1F and pat (TC1507), cp4 epsps (NK603) and aad-1 (DAS-40278-9) transgenes. These transgenes encode the proteins Cry1A.105, Cry2Ab2, and Cry1F, which confer insect resistance, PAT, CP4 EPSPS, and AAD-1, which confer herbicide tolerance. The following agronomic characteristics were assessed in the study: initial and final stand count, seedling vigor, time to silk, time to pollen shed, pollen viability, plant height, ear height, stalk lodging, root lodging, days to maturity, stay green, disease incidence, insect damage, herbicide injury, and yield. The agronomic assessment was conducted in two regions of Brazil (Indianopolis-MG; Cravinhos-SP). The agronomic attributes for all GM entries were statistically indistinguishable from the non-GM near-isogenic hybrid. In addition, most of the agronomic assessments fell within the range of the commercial varieties included in the study. Taken together, MON 89034 × TC1507 × NK603 × DAS-40278, MON 89034 × TC1507 × NK603, and DAS-40278-9 were found to be agronomically equivalent to non-GM corn.

  13. Alterations in the immunohistochemical expression of Das-1 and CG-3 in colonic mucosal biopsy specimens helps distinguish ulcerative colitis from Crohn disease and from other forms of colitis.

    PubMed

    Yantiss, Rhonda K; Das, Kiron M; Farraye, Francis A; Odze, Robert D

    2008-06-01

    Distinction between ulcerative colitis (UC) and Crohn disease (CD) in mucosal biopsies is often difficult. Das-1 and CG-3 are monoclonal antibodies directed against an unknown colonic epithelial protein and human tropomyosin isoform-5, respectively, both show altered expression in patients with UC. In this study, we evaluated the utility of Das-1 and CG-3 in distinguishing UC from CD and from other types of colitis. One colonic biopsy specimen from each of 85 patients with confirmed UC (n=25), CD (n=15), lymphocytic (n=15), collagenous (n=15), and ischemic (n=15) colitis, and also 10 samples from normal controls, were stained for Das-1 and CG-3 using standard techniques. Reactivity for Das-1 and CG-3 was noted to be absent or present, and the location (ie, surface+/-crypt epithelium) and degree (weak or strong) of CG-3 staining was recorded. Loss of Das-1 staining occurred more frequently in UC (96%) compared with CD (20%), lymphocytic (20%), collagenous (13%), and ischemic colitis (0%) cases, as well as controls (10%, P<0.001 for all comparisons). CG-3 positivity in crypt epithelium was significantly more common in UC (52%) compared with the other groups (P< or =0.02 for all comparisons). The combination of strong crypt CG-3 staining and loss of Das-1 staining was noted in 44% of UC cases, but not in any other type of colitis (P=0.003 for all comparisons). We conclude that the patterns of Das-1 and CG-3 staining in colonic mucosal biopsies may be clinically useful in distinguishing UC from CD and from other colitidies.

  14. [Maternal mortality in the Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto (USP) from 1957 to 1977. Pt. 1: Incidence (Author's transl)].

    PubMed

    Parente, J V; Martinez, A R; Franco Jg; De Carvalho, R L; Carravazzo, N C; Meirelles, R S

    1979-08-01

    A study was carried out from 1957-1977 which investigated the incidence of maternal mortality in the Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto. The yearly distribution of these deaths related to the resolution of pregnancy always showed predominance of the abortion group over the others (pregnant patients, normal delivery, and surgical delivery), with increased evidence starting at the beginning of the 1970's. When the deaths were distributed by relating pregnancy resolution to marital status, absolute predominance of married over single patients was observed, including the abortion group. When the site of the 21st obstetrical aid was considered, it was observed that in 17 of 68 cases studied, the patients were directed to another hospital or delivered at home assisted by a midwife. The mortality rate for the entire period studied was 22.04%. When the cases receiving 1st obstetrical aid outside the Hospital das Clinicas are subtracted, the rate drops to 16.53% and to 8.1% when the abortion group is also excluded. On the basis of these data, it was concluded that abortion is the greatest medical-social problem detected in this study.

  15. Development of multiplex PCR method for simultaneous detection of four events of genetically modified maize: DAS-59122-7, MIR604, MON863 and MON88017.

    PubMed

    Oguchi, Taichi; Onishi, Mari; Mano, Junichi; Akiyama, Hiroshi; Teshima, Reiko; Futo, Satoshi; Furui, Satoshi; Kitta, Kazumi

    2010-01-01

    A novel multiplex PCR method was developed for simultaneous event-specific detection of four events of GM maize, i.e., DAS-59122-7, MIR604, MON88017, and MON863. The single laboratory examination of analytical performance using simulated DNA mixtures containing GM DNA at various concentrations in non-GM DNA suggested that the limits of detection (LOD) of the multiplex PCR method were 0.16% for MON863, MIR604, and MON88017, and 0.078% for DAS-59122-7. We previously developed a nonaplex (9plex) PCR method for eight events of GM maize, i.e., Bt11, Bt176, GA21, MON810, MON863, NK603, T25, and TC1507. Together with the nonaplex PCR method, the newly developed method enabled the detection and identification of eleven GM maize events that are frequently included in commercial GM seed used in Japan. In addition, this combinational analysis may be useful for the identification of combined event products of GM maize.

  16. Metabolism and Residues of 2,4-Dichlorophenoxyacetic Acid in DAS-40278-9 Maize (Zea mays) Transformed with Aryloxyalkanoate Dioxygenase-1 Gene.

    PubMed

    Zhou, Xiao; Rotondaro, Sandra L; Ma, Mingming; Rosser, Steve W; Olberding, Ed L; Wendelburg, Brian M; Adelfinskaya, Yelena A; Balcer, Jesse L; Blewett, T Craig; Clements, Bruce

    2016-10-12

    DAS-40278-9 maize, which is developed by Dow AgroSciences, has been genetically modified to express the aryloxyalkanoate dioxygenase-1 (AAD-1) protein and is tolerant to phenoxy auxin herbicides, such as 2,4-dichlorophenoxyacetic acid (2,4-D). To understand the metabolic route and residue distribution of 2,4-D in DAS-40278-9 maize, a metabolism study was conducted with (14)C-radiolabeled 2,4-D applied at the maximum seasonal rate. Plants were grown in boxes outdoors. Forage and mature grain, cobs, and stover were collected for analysis. The metabolism study showed that 2,4-D was metabolized to 2,4-dichlorophenol (2,4-DCP), which was then rapidly conjugated with glucose. Field-scale residue studies with 2,4-D applied at the maximum seasonal rate were conducted at 25 sites in the U.S. and Canada to measure the residues of 2,4-D and free and conjugated 2,4-DCP in mature forage, grain, and stover. Residues of 2,4-D were not detectable in the majority of the grain samples and averaged <1.0 and <1.5 μg/g in forage and stover, respectively. Free plus conjugated 2,4-DCP was not observed in grain and averaged <1.0 μg/g in forage and stover.

  17. Brazil's premier gold province. Part I: The tectonic, magmatic, and structural setting of the Archean Rio das Velhas greenstone belt, Quadrilátero Ferrífero

    NASA Astrophysics Data System (ADS)

    Lobato, Lydia; Ribeiro-Rodrigues, Luiz; Zucchetti, Márcia; Noce, Carlos; Baltazar, Orivaldo; da Silva, Luiz; Pinto, Claiton

    2001-07-01

    Rocks of the Rio das Velhas Supergroup comprise one of the most significant Archean greenstone-belt successions in Brazil, in both their appreciable mineral productivity and extensive mineral potential. A large part of this greenstone belt is contained within the Quadrilátero Ferrífero (Iron Quadrangle) region, Minas Gerais state, southeastern Brazil, which occupies the southernmost portion of the São Francisco craton. The Nova Lima Group rocks, at the base of the Rio das Velhas greenstone belt, host important orogenic gold deposits. The group contains lithological associations from bottom to top as follows: (1) mafic-ultramafic volcanic, (2) volcanic-chemical, (3) clastic-chemical, (4) volcaniclastic, and (5) resedimented rocks. Rocks of the resedimented, volcanic-chemical, and mafic-ultramafic volcanic associations mainly host the most important gold deposits. An early compressional deformation occurs in the rocks of the Rio das Velhas greenstone belt and basement gneisses, with tangential thrusting from the north to the south or southwest. Structures generated during a second, compressional deformation, encompass NW-striking thrust faults and SW-vergent, tight to isoclinal folds, inferring a general southwest transport direction. In the central portion of the Quadrilátero Ferrífero, the Paciência lineament, which strikes northwest and dips to the northeast in the south, or strikes northeast and dips to the southeast in the north, is a thrust-related, oblique ramp fault that hosts important gold deposits. The convergence of these two trends in the Nova Lima region is accommodated by roughly E-W-striking transcurrent faults, which are the most favored sites for large gold concentrations. Intracratonic extension in Late Archean to early Paleoproterozoic times and NW-vergent, Trans-Amazonian compressional deformation post-date gold deposition. Late extension during the Paleoproterozoic led to basin formation and the prominent dome-and-keel architecture of the

  18. Feeling Normal? Long-Term Follow-up of Patients with a Cleft Lip-Palate after Rhinoplasty with the Derriford Appearance Scale (DAS-59).

    PubMed

    Albers, Andreas E; Reichelt, Andreas C; Nolst-Trenité, Gilbert J; Menger, Dirk Jan

    2016-04-01

    The stigma of nasal deformity due to a congenital cleft lip-palate has an undeniable influence on the affected patient's life. It is therefore of interest to investigate if efforts to reduce esthetic and functional impairments by rhinoplasty (single or multiple) can result in an increased satisfaction with appearance and a self-perception similar to the noncleft population. Retrospective scoring before and after rhinoplasty using the validated Derriford Appearance Scale (DAS-59) and subsequent statistical evaluation and comparison to datasets available in the literature for further classification was used. Of the 61 patients who underwent at least one rhinoplasty, 26 responded to all questions. The mean age of responders was approximately 30 years of age and the male:female ratio was 1:1.2. The scale showed a significant overall improvement after surgery. The full scale and all subscale scores of the DAS-59 were significantly reduced after surgery demonstrating an improvement in the respective categories. Most importantly, if postoperative results were compared with a population concerned and unconcerned about appearance, no difference "facial self-consciousness" of appearance was apparent. Also postoperative subscores for "general self-consciousness" (GSC) and "social self-consciousness" of appearance (SSC) showed no difference from those obtained from the population concerned about appearance. The postoperative subscore for "sexual and bodily self-consciousness" of appearance (SBSC) indicated improvement beyond the level found in the concerned control population. Due to only a low improvement in the difference compared with the subscore representing a "negative self-concept," a statistically significant difference to the concerned population remained, possibly indicating that therapy beyond surgery is needed for improvement. After rhinoplasty, the investigated group of cleft lip-palate patients with nasal deformities showed an improvement in their self

  19. Relationship between time-integrated disease activity estimated by DAS28-CRP and radiographic progression of anatomical damage in patients with early rheumatoid arthritis

    PubMed Central

    2011-01-01

    Background The main aim of the study was to investigate the relationship between persistent disease activity and radiographic progression of joint damage in early rheumatoid arthritis (ERA). Methods Forty-eight patients with active ERA was assessed every 3 months for disease activity for 3 years. Radiographic damage was measured by the Sharp/van der Heijde method (SHS). The cumulative inflammatory burden was estimated by the time-integrated values (area under the curve-AUC) of Disease Activity Score 28 joint based on C-reactive protein (DAS28-CRP) in rapid progressors versus non-progressors. Bland and Altman's 95% limits of agreement method were used to estimate the smallest detectable difference (SDD) of radiographic progression. The relationship between clinical and laboratory predictors of radiographic progression and their interactions with time was analysed by logistic regression model. Results After 3-years of follow-up, radiographic progression was observed in 54.2% (95%CI: 39.8% to 67.5%) of patients and SDD was 9.5 for total SHS. The percentage of patients with erosive disease increased from 33.3% at baseline to 76% at 36 months. The total SHS of the progressors worsened from a median (interquartile range) of 18.5 (15-20) at baseline to 38.5 (34-42) after 3 years (p < 0.0001) whereas non-progressors worsened from a median of 14.5 (13-20) at baseline to 22.5 (20-30) after 3 years (p < 0.001). In the regression model, time-integrated values of DAS28-CRP and anti-CCP positivity have the highest positive predictive value for progression (both at level of p < 0.0001). Radiographic progression was also predicted by a positive IgM-RF (p0.0009), and a high baseline joint damage (p = 0.0044). Conclusions These data indicate that the level of disease activity, as measured by time-integrated DAS28-CRP, anti-CCP and IgM-RF positivity and a high baseline joint damage, affects subsequent progression of radiographic damage in ERA. PMID:21624120

  20. Short-term monitoring of a gas seep field in the Katakolo bay (Western Greece) using Raman spectra DTS and DAS fibre-optic methods

    NASA Astrophysics Data System (ADS)

    Chalari, A.; Mondanos, M.; Finfer, D.; Christodoulou, D.; Kordella, S.; Papatheodorou, G.; Geraga, M.; Ferentinos, G.

    2012-12-01

    A wide submarine seep of thermogenic gas in the Katakolo bay, Western Greece, was monitored passively using the intelligent Distributed Acoustic Sensor (iDAS) and Ultima Raman spectra Distributed Temperature Sensor (DTS), in order to study the thermal and noise signal of the bubble plumes released from the seafloor. Katakolo is one one of the most prolific thermogenic gas seepage zones in Europe and the biggest methane seep ever reported in Greece. Very detailed repetitive offshore gas surveys, including marine remote sensing (sub-bottom profiling, side scan sonar), underwater exploration by a towed instrumented system (MEDUSA), long-term monitoring benthic station (GMM), compositional and isotopic analyses, and flux measurements of gas, showed that: (a) gas seepage takes place over an extended area in the Katakolo harbour and along two main normal faults off the harbour; (b) at least 823 gas bubble ( 10-20 cm in diameter) plumes escaping over an area of 94,200 m2, at depths ranging from 5.5 to 16 m; (c) the gas consists mainly of methane and has H2S levels of hundreds to thousands ppmv, and shows significant amounts of other light hydrocarbons like ethane, propane, iso-butane and C6 alkanes, (d) offshore and onshore seeps release the same type of thermogenic gas; (e) due to the shallow depth, more than 90 % of CH4 released at the seabed enters the atmosphere, and (f) the gas seeps may produce severe geohazards for people, buildings and construction facilities due to the explosive and toxicological properties of methane and hydrogen sulfide, respectively. For the short-term monitoring, the deployment took place on a site located inside the harbour of Katakolo within a thermogenic gas seepage area where active faults are intersected. The iDAS system makes it possible to observe the acoustical signal along the entire length of an unmodified optical cable without introducing any form of point sensors such as Bragg gratings. When the bubble plumes are released by the

  1. Dating human occupation at Toca do Serrote das Moendas, São Raimundo Nonato, Piauí-Brasil by electron spin resonance and optically stimulated luminescence.

    PubMed

    Kinoshita, Angela; Skinner, Anne R; Guidon, Niede; Ignacio, Elaine; Felice, Gisele Daltrini; Buco, Cristiane de A; Tatumi, Sonia; Yee, Márcio; Figueiredo, Ana Maria Graciano; Baffa, Oswaldo

    2014-12-01

    Excavation of Toca do Serrote das Moendas, in Piauí state, Brazil revealed a great quantity of fossil wild fauna associated with human remains. In particular, fossils of a cervid (Blastocerus dichotomus) were found, an animal frequently pictured in ancient rock wall paintings. In a well-defined stratum, two loose teeth of this species were found in close proximity to human bones. The teeth were independently dated by electron spin resonance (ESR) in two laboratories. The ages obtained for the teeth were 29 ± 3 ka (thousands of years) and 24 ± 1 ka. The concretion layer capping this stratum was dated by optically stimulated luminescence (OSL) of the quartz grains to 21 ± 3 ka. As these values were derived independently in three different laboratories, using different methods and equipment, these results are compelling evidence of early habitation in this area.

  2. Registry of Hospital Das Clínicas of the University of São Paulo Medical School: First Official Solid Organ and Tissue Transplantation Report – 2008

    PubMed Central

    Azeka, Estela; Auler Júnior, José Otavio Costa; Fernandes, Paulo Manuel Pego; Nahas, Willian Carlos; Fiorelli, Alfredo Inácio; Tannuri, Uenis; Cristofani, Lílian Maria; Caiero, Marcelo Tadeu; Dulley, Frederico Luiz; de Oliveira Paggiaro, André; Bacchella, Telesforo

    2009-01-01

    OBJECTIVE: The aim of this study was to report a single center experience of organ and tissue transplantation INTRODUCTION: This is the first report of organ and tissue transplantation at the Hospital das Clínicas of the University of Sao Paulo Medical School. METHODS: We collected data from each type of organ transplantation from 2002 to 2007. The data collected were patient characteristics and actuarial survival Kaplan-Meier curves at 30 days, one year, and five years RESULTS: There were a total of 3,321 transplants at our institution and the 5-year survival curve ranged from 53% to 88%. CONCLUSION: This report shows that solid organ and tissue transplants are feasible within the institution and allow us to expect that the quality of transplantation will improve in the future. PMID:19219318

  3. Application of a Fibre Optic Distributed Acoustic Sensor (DAS) for Shallow Seismic Investigations of a Fractured Dolostone Aquifer in Guelph, Ontario.

    NASA Astrophysics Data System (ADS)

    Munn, J. D.; Parker, B. L.; Coleman, T. I.; Mondanos, M.; Chalari, A.

    2014-12-01

    Understanding groundwater flow and contaminant transport in fractured bedrock aquifers requires detailed characterization of the discrete features that control flow, as well as the properties of the rock matrix. This requires multiple, high-resolution, depth discrete datasets that provide different, but complementary information. Distributed fibre optic sensing is a relatively new technology used to continuously monitor properties along the entire length of an optical fibre. Technological advances over the past few years have brought the sensitivity and spatial resolution to the point where shallow (<200m) borehole applications are practicable. Recent studies using fibre optic distributed temperature sensors (DTS) have shown excellent application of DTS for characterizing groundwater flow in both continuously sealed and open boreholes. This presentation highlights the results of a field trial at the Bedrock Aquifer Research Station on the University of Guelph campus (Ontario, Canada) where a single fibre optic cable was interrogated by both a DTS (Ultima-DTS) and a Distributed Acoustic Sensor (iDAS). DAS is a relatively recent development that allows an optical fibre to be used as a receiver for seismic imaging. These seismic images are produced by sending an optical pulse down the fibre and analyzing the effects of seismic waves on the propagating light. Numerous vertical seismic profiles were collected and the effects of different fibre optic cable structures and coupling techniques were examined. The seismic profiles will help delineate structural features and lithological contacts away from the borehole wall, and will assist in correlating other geophysical, hydraulic, or geological logs collected in the boreholes across the site. Preliminary results show promise for shallow seismic imaging and continued field trials will allow refinement of the technique.

  4. Evaluation of two evidence-based knowledge transfer interventions for physicians. A cluster randomized controlled factorial design trial: the CardioDAS Study.

    PubMed

    Amsallem, Emmanuel; Kasparian, Christelle; Cucherat, Michel; Chabaud, Sylvie; Haugh, Margaret; Boissel, Jean-Pierre; Nony, Patrice

    2007-12-01

    To investigate the potential benefits of two modes of evidence-based knowledge transfer ('active' and 'passive' modes) in terms of improvement of intention of prescription, knowledge, and real prescription in practice, we performed an open randomized controlled trial (CardioDAS) using a factorial design (two tested interventions: 'active' and 'passive' knowledge transfer) and a hierarchical structure (cluster of physicians for each department level). The participants were cardiologists working in French public hospitals. In the 'passive' transfer group, cardiologists received evidence-based knowledge material (available on Internet) every week for a duration of 1 year. In the 'active' transfer group, two knowledge brokers (EA, PN) visited the participating departments (every 2 months for 1 year, 2 h per visit). The primary outcome consisted in the adjusted absolute mean variation of score (difference between post- and pre-study session) of answers to simulated cases assessing the intention to prescribe. Secondary outcomes were the variation of answers to a multiple-choice questionnaire (MCQ) assessing knowledge and of the conformity of real prescriptions to evidence-based reference assessing the behavioral change. Twenty-two French units (departments) of cardiology were randomized (72 participating cardiologists). In the 'active' transfer group, the primary outcome was more improved than that in the control (P = 0.031 at the department level, absolute mean improvement of 5 points/100). The change in knowledge transfer (MCQ) was also significant (P = 0.039 at the department level, absolute mean improvement of 6 points/100). However, no benefit was shown in terms of prescription conformity to evidence. For the 'passive' mode of knowledge transfer and for the three outcomes considered, no improvement was identified. CardioDAS findings confirm that 'active' knowledge transfer has some impact on participants' intent to prescribe and knowledge, but no effect on

  5. Medicina integrativa en América: De qué forma se está practicando la medicina integrativa en los centros clínicos en los Estados Unidos

    PubMed Central

    Horrigan, Bonnie; Lewis, Sheldon; Abrams, Donald I.; Pechura, Constance

    2012-01-01

    RESUMEN EJECUTIVO El impulso para desarrollar e implementar estrategias de medicina integrativa está enraizado en el deseo de mejorar la atención al paciente. The Bravewell Collaborative, una organización sin ánimo de lucro dedicada a la mejora de la atención sanitaria, define la medicina integrativa como “un enfoque de la medicina que coloca al paciente en el centro y se dirige al conjunto completo de influencias físicas, emocionales, mentales, sociales, espirituales y ambientales que afectan a la salud de la persona. Con una estrategia personalizada que considera las condiciones, necesidades y circunstancias únicas del paciente, utiliza las intervenciones más apropiadas de una variedad de disciplinas científicas para curar la afección y la enfermedad y ayudar a las personas a recobrar y mantener una salud óptima”. En las pasadas dos décadas, se ha documentado un número creciente de centros clínicos que proporcionan medicina integrativa, el número de facultades y escuelas médicas que enseñan estrategias integrativas, el número de investigadores que estudian intervenciones integrativas, y el número de pacientes que solicitan cuidados integrativos. Pero se desconocía si la medicina integrativa se estaba ofreciendo de manera igual, similar, o dispar. Además, mientras que los estudios anteriores se centraban en la prevalencia y el uso de la medicina complementaria o alternativa (MCA) por parte de los pacientes1,2 o de los médicos en hospitales3, enumerando la utilización de terapias MCA individuales, se había recogido muy poca información con respecto a la práctica real de la medicina integrativa que, por definición, trata a la persona en su conjunto. En 2011, The Bravewell Collaborative encargó una encuesta para determinar la forma en que la medicina integrativa se estaba practicando en los Estados Unidos: (1) describiendo las poblaciones de pacientes y las afecciones sanitarias tratadas más habitualmente; (2) definiendo las pr

  6. Simultaneous functions of the installed DAS/DAK formaldehyde-assimilation pathway and the original formaldehyde metabolic pathways enhance the ability of transgenic geranium to purify gaseous formaldehyde polluted environment.

    PubMed

    Zhou, Shengen; Xiao, Sunqin; Xuan, Xiuxia; Sun, Zhen; Li, Kunzhi; Chen, Limei

    2015-04-01

    The overexpression of dihydroxyacetone synthase (DAS) and dihydroxyacetone kinase (DAK) from methylotrophic yeasts in chloroplasts created a photosynthetic formaldehyde (HCHO)-assimilation pathway (DAS/DAK pathway) in transgenic tobacco. Geranium has abilities to absorb and metabolize HCHO. Results of this study showed that the installed DAS/DAK pathway functioning in chloroplasts greatly enhanced the role of the Calvin cycle in transgenic geranium under high concentrations of gaseous HCHO stress. Consequently, the yield of sugars from HCHO-assimilation increased approximately 6-fold in transgenic geranium leaves, and concomitantly, the role of three original HCHO metabolic pathways reduced, leading to a significant decrease in formic acid, citrate and glycine production from HCHO metabolism. Although the role of three metabolic pathways reduced in transgenic plants under high concentrations of gaseous HCHO stress, the installed DAS/DAK pathway could still function together with the original HCHO metabolic pathways. Consequently, the gaseous HCHO-resistance of transgenic plants was significantly improved, and the generation of H2O2 in the transgenic geranium leaves was significantly less than that in the wild type (WT) leaves. Under environmental-polluted gaseous HCHO stress for a long duration, the stomata conductance of transgenic plants remained approximately 2-fold higher than that of the WT, thereby increasing its ability to purify gaseous HCHO polluted environment.

  7. Multispectral Analysis of Surface Wave (MASW) Analysis of Near-Surface Structure at Brady Hot Springs from Active Source and Ambient Noise Using a 8700-meter Distributed Acoustic Sensing (DAS) Array

    NASA Astrophysics Data System (ADS)

    Wang, H. F.; Lord, N. E.; Zeng, X.; Fratta, D.; Feigl, K. L.; Team, P.

    2016-12-01

    The Porotomo research team deployed 8700-meters of Distributed Acoustic Sensing (DAS) cable in a shallow trench on the surface and 400 meters down a borehole at Brady Hot Springs, Nevada in March 2016. The goal of the experiment was to detect changes in geophysical properties associated with hydrologic changes. The DAS cable occupied a natural laboratory of 1500-by-500-by-400-meters overlying a commercial, geothermal field operated by Ormat Technologies. The DAS cable was laid out in three parallel zig-zag lines with line segments approximately 120-meters in length. A large Vibroseis truck (T-Rex) provided the seismic source with a sweep frequency between 5 and 80 Hz over 20 seconds. Over the 15 days of the experiment, the Vibroseis truck re-occupied approximately 250 locations outside and within the array days while changes were made in water reinjection from the power plant into wells in the field. At each source location, one vertical and two orthogonal horizontal modes were excited. Dispersion curves were constructed using MASW and a Vibroseis source location approximately in line with each DAS cable segment or from ambient noise correlation functions. Representative fence diagrams of S-wave profiles were constructed by inverting the dispersion curves obtained for several different line segments.

  8. Tão perto de casa, tão longe de nós: etnografia das novas margens no centro da urbe

    PubMed Central

    Fernandes, Por Luís

    2011-01-01

    Philippe Bourgois é, desde 2007, “Richard Perry University professor” no Departamento de Antropologia e de Medicina Familiar e de Práticas Comunitárias na Universidade da Pensilvânia. Esteve durante largos anos ligado ao Departamento de Antropologia, História e Medicina Social da Universidade da Califórnia, São Francisco. A publicação, em 1995, de In Search of Respect: Selling Crack in El Barrio1 projectaria o seu nome muito para além dos Estados Unidos: uma etnografia no coração porto-riquenho do Harlem, em torno dos actores e dos ambientes da venda de crack. Seguir-se-ia um longo trabalho de terreno em acampamentos de dependentes de heroína em São Francisco, orientando o seu trabalho para as formas mais radicais da pobreza e da marginalidade nos EUA. É deste trabalho de terreno que sai o seu último livro, Righteous Dopefiend2. Em Junho de 2007 esteve em Lisboa para participar na 3.a edição do “Ethnografeast”. Foi então que aproveitámos a oportunidade para ouvir um percurso invulgar contado pelo próprio: uma longa conversa no Hotel Zurique, cujo nome só vem ao caso por evocar o país onde passou uma parte da infância. PMID:22013286

  9. Further evidence of 777 Ma subduction-related continental arc magmatism in Eastern Dom Feliciano Belt, southern Brazil: The Chácara das Pedras Orthogneiss

    NASA Astrophysics Data System (ADS)

    Koester, E.; Porcher, C. C.; Pimentel, M. M.; Fernandes, L. A. D.; Vignol-Lelarge, M. L.; Oliveira, L. D.; Ramos, R. C.

    2016-07-01

    In this study new SHRIMP U-Pb zircon data for the Chácara das Pedras Gneiss in Porto Alegre, southern Brazil are presented. They represent a small exposure of the crust which was intruded by a large volume of orogenic to anorogenic granitoids at ca. 618-562 m.y. in the Eastern Domain of the Dom Feliciano Belt. The Chácara das Pedras tonalitic orthogneiss has geochemical similarities with subduction-related magmatic rocks of continental arcs. They present high Sr initial ratios (∼0.712), negative ɛNd(t = 777) values (∼-6), TDM varying from 1.8 to 2.0 Ga. The igneous protoliths of these orthogneisses were previously considered to be Paleoproterozoic based on an upper intercept age of discordant zircon analyses. In the present study these orthogneisses were re-sampled and re-analyzed in an attempt to obtain more concordant analytical data. The U-Pb zircon analyses were carried out using the SHRIMP IIe at the Laboratório de Geocronologia de Alta Resolução of the Universidade de São Paulo. The U-Pb concordia age obtained for igneous textural domains of the zircon grains is 777 ± 4 Ma. A few analyses on zircon overgrowths give poorly defined late Cryogenian ages of ca. 650 Ma. Older ages, mostly discordant, were obtained in a few zircon cores, showing an upper intercept age of ca. 1.9 Ga. One sample of the Três Figueiras Granodiorite, which crosscut the orthogneiss in the same outcrop, was also investigated. The zircons of this granodiorite are, however, mostly metamitic, preventing the determination of a reliable age. Some concordant analyses from a few grains define ages ranging in the interval between ca. 603 and 1022 Ma. The youngest (ca. 603 Ma) may represent a maximum age for the granodiorite crystallization. Older ages, with discordance <10%, are of 745, 777, 836 and 1022 Ma. The 777 ± 4 Ma age obtained for the Chácara das Pedras orthogneiss is the first Early Cryogenian magmatic age determined for granitoids in the Porto Alegre region, although

  10. Water Quality-Quantity Evaluation of the Ribeirão das Posses Watershed, Brazil, applying the AgES-W model.

    NASA Astrophysics Data System (ADS)

    Green, T. R.; Cruz, P. P. N. D.; Figueiredo, R. D. O.; Camargo, P. B. D.; Santos, C. P.

    2015-12-01

    Southeastern Brazil is under a period of drought that has impacted the conservation of watersheds and the management of water quality and quantity for agricultural and urban demands. In this context agro-hydrological modeling tools can generate information of water response over time in response to climate and landuse changes. A 12-km2 watershed which has suffered from anthropogenic activities is the Ribeirão das Posses watershed that is located in the extreme south of Minas Gerais State and is a headwater catchment of the Jaguari river, one of the contributing rivers of the Cantareira Reservoir Complex in the state of São Paulo. This watershed had its landscape changed over the last century from native forests to more homogeneous vegetation for pastures and small crops and some forest plantations fragments with eucalyptus. Currently, the Conservative Waters project has planted some small areas with vegetation of native species, especially where there are springs and at the top of the hills, in order to recover degraded areas and improve the hydrogeochemistry in this study basin. In this context, the AgroEcoSystem-Watershed (AgES-W) model is presented to simulate the water movement and storage in agricultural watersheds with different spatial resolutions of land areas or hydrological responses units. The objectives are to evaluate the quality and quantity of water in Ribeirão das Posses Basin using measured data, then simulate these responses in space and time to test the AgES-W model. The period chosen for research was from 2011 to 2015, because the water quality data were collected during this period. The answers that we hope to find out are: How well does the AgES-W model simulate this Brazilian watershed in the tropics? What are the future prospects of the quality and quantity of water in this basin? The results will help to guide hydrological simulations in similar tropical environments in Brazil in this and other agricultural watersheds with AgES-W.

  11. Simulation of sampling error of average rainfall rates in space and time by five satellites using radar-AMeDAS composites

    NASA Astrophysics Data System (ADS)

    Iida, Yasuhisa; Okamoto, Ken'ichi; Ushio, Tomoo; Oki, Riko

    2006-01-01

    Sampling error has long been an important issue in satellite-based rainfall measuring mission planning such as for TRMM and GPM (Global Precipitation Measurement), and in evaluating global maps of space-time average rain rate from multi-satellite rainfall data. Sampling errors due to sparse space-time rainfall observations from five currently operated low-earth-orbiting satellites (Aqua, DMSP-F13, F14, F15, TRMM (Tropical Rainfall Measuring Mission)) were evaluated using 3-year radar-AMeDAS composite data around Japan. We simulate realistic observational patterns for the satellite-borne microwave radiometers. Root-mean-square sampling error is expressed as a fraction of true average rain rate. We formulate sampling error as a function of space scale ranging from 0.1° to 5.0°, time scale from 1 to 30 (day), and true average rain rate from 0.001 to 15 (mm/h) for five different combinations of these five satellites.

  12. Dating of fossil human teeth and shells from Toca do Enoque site at Serra das Confusões National Park, Brazil.

    PubMed

    Kinoshita, Angela; Sullasi, Henry L; Asfora, Viviane K; Azevedo, Renata L; Guzzo, Pedro; Guidon, Niede; Figueiredo, Ana Maria G; Khoury, Helen; Pessis, Anne-Marie; Baffa, Oswaldo

    2016-06-07

    This work reports the dating of a fossil human tooth and shell found at the archaeological site Toca do Enoque located in Serra das Confusões National Park (Piauí, Brazil). Many prehistoric paintings have been found at this site. An archaeological excavation unearthed three sepulchers with human skeletons and some shells. Two Brazilian laboratories, in Ribeirão Preto (USP) and Recife (UFPE), independently performed Electron Spin Resonance (ESR) measurements to date the tooth and the shell and obtain the equivalent dose received by each sample. The laboratories determined similar ages for the tooth and the shell (~4.8 kyBP). The results agreed with C-14 dating of the shell and other samples (charcoal) collected in the same sepulcher. Therefore, this work provides a valid inter-comparison of results by two independent ESR-dating laboratories and between two dating methods; i.e., C-14 and ESR, showing the validity of ESR dating for this range of ages.

  13. Using a multi-user desktop-based virtual reality system to recreate the São Miguel das Missões ruins.

    PubMed

    dos Santos, Selan R; Fraga, Letícia S

    2002-10-01

    This paper presents a project initiated back in 1999, in which Virtual Reality is applied in order to create a virtual community over the Internet. The desktop-based multi-user virtual reality system recreates a three-dimensional environment based on photogrammetric maps from the São Miguel das Missões church ruins. The ruins correspond to one of the Jesuit Mission (settlement) which was active in the south of Brazil in the 17th and 18th centuries. It has a great importance to the local region in terms of cultural, historic, and tourist aspects. It has also been inscribed in the UNESCO's world heritage list since 1983. This electronic mock-up allows several interactive operations such as community chats, electronic message exchanging, message boards, walking-through, discussion groups, and embedding of other media such as movies, sound, and html pages. The only requirement necessary to access the community is a web browser powered with any Virtual Reality Modeling Language (VRML) plug-in freely available over the Internet. It is expected that such a solution improves the conservation and dissemination of the Brazilian historic patrimony, congregating history, art, and tourist information in one place on the Internet.

  14. A prospective study of dentoalveolar trauma at the Hospital das Clínicas, São Paulo University Medical School.

    PubMed

    Rezende, Fernanda Mendes do Carmo; Gaujac, Cristiano; Rocha, André Caroli; Peres, Maria Paula Siqueira de Melo

    2007-04-01

    This prospective study evaluated the profile of patients with dentoalveolar trauma assisted at the emergency room of the Oral and Maxillofacial Trauma and Surgery Service at the Hospital das Clínicas, São Paulo University Medical School (Brazil). A prospective study by a questionnaire applied during the first attendance of those patients, in a period of eight months. The collected data were statistically analyzed. It was observed that 4.7% of the patients that sought treatment at the Service had sustained dentoalveolar trauma and among these 74% were male. The most affected individuals were children aged 0 to 5 years and fall was the most prevalent etiologic factor. Avulsion and coronal/crown-root fractures were the most common types of dentoalveolar traumatic injures. As the age increases, the most common etiologic factors are traffic accidents and physical assault. The incidence of dentoalveolar trauma decreased with age and the main etiologic factors in adult patients were traffic accidents and physical assault.

  15. The Serra das Araras Batholith: An example of Ediacaran syntectonic peraluminous granitic magmatism in the southwestern Paraíba do Sul Domain

    NASA Astrophysics Data System (ADS)

    Retamal, Iuri; Machado, Rômulo; Philipp, Ruy Paulo; Lana, Cristiano; Gonçalves, Guilherme O.

    2017-10-01

    The Serra das Araras Batholith (SAB), located at the southwest portion of the Paraíba do Sul Domain, Central Ribeira Belt, is composed of orthogneisses with peraluminous character. Combined LA-ICP-MS U-Pb and Lu-Hf isotopic analyses have been performed in zircon grains for a representative sample (SA-3H) of SAB. Data point to Rhyacian to Orosirian (ca. 2.1-1.8 Ga) inherited zircon cores with positive ɛHf(t) values and Ediacaran U-Pb crystallization age (595 ± 8 Ma). A leucogranite dyke (SA-3D), 15-25 cm thick, which crosscuts SAB and a biotite-hornblende quartz diorite enclave (SA-06) have been analyzed. Crystallization ages for the three samples (ca. 600-590 Ma) and ɛHf(t) values, ranging from -5.6 to -29.4 for Neoproterozoic zircon grains, indicate an Ediacaran crustal magmatism involving mid to lower crust anatexis and the reworking of Paleoproterozoic juvenile and crustal rocks.

  16. [Nutritional status of patients with breast cancer attended in the Mastology Service of Belo Horizonte's Hospital das Clínicas in the state of Minas Gerais, Brazil].

    PubMed

    de Oliveira, Dirce Ribeiro; Carvalho, Erika Simone Coelho; Campos, Liliane Cunha; Leal, José Adalberto; Sampaio, Estela Viana; Cassali, Geovanni Dantas

    2014-05-01

    The scope of this article is to evaluate the nutritional status, body composition and tumor characteristics of 31 patients with breast cancer attended at the Mastology Service of Hospital das Clínicas of the Federal University of Minas Gerais. Dietary data were obtained from the 24-hour dietary recall in the pre-operative state and analyzed by the DietWin Professional 2008 Nutrition Software. Body composition was assessed by bioelectrical impedance analysis. The tumor characterization data were collected from medical records. The mean age of patients was 50.75 ± 14.34 years. Excess body weight was found in 58% and waist circumference greater than 80 cm in 64.5% of patients Excessive consumption of oils and sugars was observed in 90.3% and 83.8%, respectively. Most had low intakes of calcium and vitamins B6, B12 and A. The predominant diagnosis was type II histological grade invasive ductal carcinoma in stage II or III. The prevalence of overweight and inadequate dietary intake demonstrate the need for individualized nutritional guidance and monitoring to improve the prognosis and quality of the life of patients.

  17. [Travelers' vaccinations: experience from the Travelers' Clinic of Hospital das Clínicas, University of São Paulo School of Medicine].

    PubMed

    Chinwa Lo, Simone; Mascheretti, Melissa; Chaves, Tânia do Socorro Souza; Lopes, Marta Heloisa

    2008-01-01

    The profile and vaccination status of travelers seeking pre-travel medical advice at the Travelers' Clinic of Hospital das Clínicas, University of São Paulo School of Medicine, and the vaccines recommended for them, were analyzed in the present study. Among the 445 travelers who were studied, 51% were women, the median age was 33.5 years, 51% were traveling on business and 39.5% were traveling for leisure purposes. The destinations most sought were Africa (47%), Asia (31.7%) and South America (21.4%). Vaccination before traveling was recommended for 385 (86.5%) of the travelers. The main vaccines recommended were against typhoid fever (55.7%), diphtheria-tetanus (54.1%), hepatitis A (46.1%), hepatitis B (44.2%) and yellow fever (24.7%). The pre-travel guidance was shown to be important not only for indicating the vaccines recommended for the trip, but also as an opportunity to update routine vaccinations.

  18. [Voice disorder clinic in the speech therapy outpatient unit at "Hospital das Clínicas da Universidade Federal de Minas Gerais"].

    PubMed

    Menezes, Letícia Neiva de; Behlau, Mara; Gama, Ana Cristina Côrtes; Teixeira, Letícia Caldas

    2011-07-01

    This study set out to describe the profile of the patients with voice complaints and/or alterations who were attended between July 2003 and December 2006 at the speech therapy outpatient unit of "Hospital das Clínicas da Universidade Federal de Minas Gerais." This was analyzed according to age, sex, profession, schooling, origin, treatment performed and factors that interfere in medical care evolution. This was a retrospective study based on the analysis of the recorded data of the individuals according to a specifically prepared Protocol. The results showed that the individuals included in this study were predominantly young women, referred by a specialist from Belo Horizonte, who do not work and also have incomplete elementary school education. Attendance of those patients was on an individual basis, and almost half of them were discharged by the speech therapist. The elderly patients, who have functional or psychogenic dysphonia and a neutral or wheezy type of voice, showed a close correlation with the discharge rate by speech therapist. The younger individuals with organo-functional dysphonia bore a statistical correlation with abandoning treatment. The individuals who eventually abandoned treatment did not bear any correlation with the crossed variables.

  19. Relation among anti-rheumatic drug therapy, CD14(+)CD16(+) blood monocytes and disease activity markers (DAS28 and US7 scores) in rheumatoid arthritis: A pilot study.

    PubMed

    Amoruso, Angela; Sola, Daniele; Rossi, Luca; Obeng, Joyce Afrakoma; Fresu, Luigia Grazia; Sainaghi, Pier Paolo; Pirisi, Mario; Brunelleschi, Sandra

    2016-05-01

    Circulating human monocytes, a functionally and phenotypically heterogeneous population, are emerging as fundamental cell types in rheumatoid arthritis (RA). The aim of this pilot study was to assess the correlation, if any, among anti-rheumatic drug therapy, circulating CD14(+)CD16(+) monocytes and validated clinical scales (e.g., DAS28 score and ultrasonography US7 score) of disease severity in RA. Thirty consecutive RA patients, either naïve or under disease-modifying anti-rheumatic drugs (DMARDs) or biological therapy, and 10 age-matched healthy volunteers, were enrolled. Monocytes were prepared from heparinized blood samples; surface expression of CD14 and CD16 was determined by flow cytometry. RA patients presented a significantly higher percentage of CD14(+)CD16(+) monocytes, as compared to healthy subjects. There was a good correlation between DAS28 clinical score and the ultrasound composite score US7 (r=0.66), as well as between both scores and the percentage of CD14(+)CD16(+) monocytes (r=0.43 and 0.47, respectively). Naïve RA patients had the highest expression (19.2±3.2%) of CD14(+)CD16(+) monocytes and elevated DAS28 score; patients on DMARDs presented a 7-fold increased expression of CD14(+)CD16(+) monocytes, relatively to healthy volunteers (2.1±1.4%), and an intermediate disease severity. The RA patients treated with biological therapy had a low percentage of CD14(+)CD16(+) monocytes (5.1±3.6%; p<0.01 vs naïve and DMARDs groups), similar to the one detected in healthy controls, and reduced US7 and DAS28 scores. Interestingly, for the same DAS28 score, monocytes isolated from RA patients on biological therapy had a lower CD16 expression than patients on DMARDs. Therefore, CD14(+)CD16(+) circulating blood monocytes may represent an appropriate biomarker to assess RA disease activity along with DAS28 and US7 scores. Together, these three parameters may represent a better indicator for evaluating therapy efficacy.

  20. Guidelines on management of human infection with the novel virus influenza A (H1N1)--a report from the Hospital das Clínicas of the University of São Paulo.

    PubMed

    Hajjar, Ludhmila Abrahao; Schout, Denise; Galas, Filomena Regina Barbosa Gomes; Uip, David Everson; Levin, Anna Sara Shafferman; Caiaffa Filho, Helio Hehl; Sakane, Pedro Takanori; Suslik, Carlos Alberto; Teixeira, Jose Manoel de Camargo; Bonfa, Eloisa; Barone, Antonio Alci; Martins, Milton de Arruda; Boulos, Marcos; Auler, Jose Otavio Costa

    2009-01-01

    The pandemic novel influenza A (H1N1) infection was considered widespread in Brazil on July, 2009. Since then, 9.249 cases were confirmed in Brazil, most of them concentrated in São Paulo. The Hospital das Clínicas of the University of São Paulo is a reference center for H1N1 cases in São Paulo. The purpose of this review is to analyze the evidence concerning diagnosis, prevention, and treatment of novel influenza A (H1N1) infection. In addition, we propose guidelines for the management of this pandemic emphasizing Hospital das Clínicas "bundles" for the control of the pandemic novel influenza A (H1N1).

  1. The geology of the Morro Velho gold deposit in the Archean Rio das Velhas greenstone belt, Quadrilátero Ferrífero, Brazil

    USGS Publications Warehouse

    Vial, Diogenes Scipioni; DeWitt, Ed; Lobato, Lydia Maria; Thorman, Charles H.

    2007-01-01

    The Morro Velho gold deposit, Quadrilátero Ferrífero region, Minas Gerais, Brazil, is hosted by rocks at the base of the Archean Rio das Velhas greenstone belt. The deposit occurs within a thick carbonaceous phyllite package, containing intercalations of felsic and intermediate volcaniclastic rocks and dolomites. Considering the temporal and spatial association of the deposit with the Rio das Velhas orogeny, and location in close proximity to a major NNW-trending fault zone, it can be classified as an orogenic gold deposit. Hydrothermal activity was characterized by intense enrichment in alteration zones of carbonates, sulfides, chlorite, white mica±biotite, albite and quartz, as described in other Archean lode-type gold ores. Two types of ore occur in the deposit: dark gray quartz veins and sulfide-rich gold orebodies. The sulfide-rich orebodies range from disseminated concentrations of sulfide minerals to massive sulfide bodies. The sulfide assemblage comprises (by volume), on average, 74% pyrrhotite, 17% arsenopyrite, 8% pyrite and 1% chalcopyrite. The orebodies have a long axis parallel to the local stretching lineation, with continuity down the plunge of fold axis for at least 4.8 km. The group of rocks hosting the Morro Velho gold mineralization is locally referred to as lapa seca. These were isoclinally folded and metamorphosed prior to gold mineralization. The lapa seca and the orebodies it hosts are distributed in five main tight folds related to F1 (the best examples are the X, Main and South orebodies, in level 25), which are disrupted by NE- to E-striking shear zones. Textural features indicate that the sulfide mineralization postdated regional peak metamorphism, and that the massive sulfide ore has subsequently been neither metamorphosed nor deformed. Lead isotope ratios indicate a model age of 2.82 ± 0.05 Ga for both sulfide and gold mineralization. The lapa seca are interpreted as the results of a pre-gold alteration process and may be

  2. Imaging Fractures Through Relative Velocity Change Using Ambient Seismic Noise And Distributed Acoustic Sensing (DAS): A SUBTER Pilot Study At Blue Canyon Dome, Socorro NM

    NASA Astrophysics Data System (ADS)

    James, S. R.; Knox, H. A.; Ajo Franklin, J. B.; Johnson, T. C.; Morris, J.; Grubelich, M. C.; King, D. K.

    2016-12-01

    Knowledge of fracture systems, including locations, morphology, and evolution, is critical for groundwater management, contaminant transport, and energy applications such as reservoir development (i.e. tight shale and geothermal) and reservoir management (i.e. carbon sequestration and wastewater injection). It has long been understood that the presence of fractures reduces bulk seismic velocity, with waves traveling perpendicular to fracture planes experiencing the strongest velocity reduction. We present results from seismic interferometry using ambient seismic noise to detect velocity changes following fracture emplacement from two energetic stimulations. Distributed Acoustic Sensing (DAS) using fiber optic cables was used to record seismic arrivals at high spatial resolution ( 3 ft). Cables were grouted in the annulus of four cased monitoring boreholes surrounding the stimulation borehole at a radius of 4 feet. Ambient noise was recorded before and after each stimulation for 12-hour time periods. We used the Python package MSNoise to compute cross-correlations of all near-horizontal (less than 60°) channel pairs between boreholes and calculated the velocity change of each time period relative to initial conditions prior to stimulation. Results show an average velocity decrease of approximately 6% following the first fracturing event. Variations between channel pairs suggest some are more strongly affected than others, which is supported by evaluation of other geophysical data. These results show promise for locating fractures based on spatial variation in velocity changes. Unsurprisingly, results following the second stimulation are generally more scattered. Some velocities are further reduced compared to those after the first stimulation while others show a relative velocity increase. These results are roughly consistent with time-lapse seismic measurements conducted using active sources and classical sensors (e.g. hydrophones). Sandia National Laboratories is

  3. Using the DAS-ELISA Test to Establish an Effective Distance Between Bait Stations for Control of Linepithema humile (Hymenoptera: Formicidae) in Natural Areas.

    PubMed

    Song, Jinbo; Benson, Eric P; Zungoli, Patricia A; Gerard, Patrick; Scott, Simon W

    2015-08-01

    Linepithema humile (Mayr), the Argentine ant, is an invasive pest that has spread throughout the United States and is a problem in natural and managed habitats in South Carolina. Foraging patterns and the effectiveness of liquid baits for control of this pest have been studied in urban areas. However, similar studies have not been conducted in natural areas such as parks, picnic grounds, or campsites. L. humile populations can be large and widespread, making them a major nuisance pest for visitors to these natural areas. The primary objective of this study was to determine an effective distance between bait stations for control of L. humile in a natural area. A double antibody-sandwich enzyme-linked immunosorbent assay (DAS-ELISA) procedure was used to detect individual ants that consumed rabbit immunoglobin (IgG) protein for marking and tracking. In both lab and field conditions, there was a significant difference in the detection of IgG in ants fed protein marker mixed with sugar water compared with ants only fed sugar water. Additional field studies revealed that an individual ant could retain detectable levels of protein marker for 3 d and that an ant feeding on IgG containing bait could be detected over 15 m from the original bait source. Overall, we found that using liquid ant baits, with a placement of 20 m between stations, was effective in reducing L. humile numbers between April to October, 2012 in a natural park area of Lake Greenwood State Park, SC.

  4. Cometas: Das Lendas aos Fatos

    NASA Astrophysics Data System (ADS)

    Voelzke, M. R.

    O descobrimento de cometas, devido ao seu aparecimento espetacular, tem registro nas mais antigas culturas humanas. A primeira referência situa-se no ano de 1095 antes de Cristo [a.C.; HO; HO, 1962]. A quantidade de registros de descobrimentos cometários, principalmente provenientes do território chinês em particular e do oriente em geral, aumentou gradualmente a partir do quarto século depois de Cristo (d.C.). É de origem chinesa a primeira referência ao cometa P/Halley no ano de 240 a.C. [VOELZKE, 1993]. Com o desenvolvimento da astronomia relativamente às técnicas observacionais os descobrimentos bem como as observações cometárias aumentaram sensivelmente a partir do século XVII, sendo que a partir do século XIX um novo incremento ocorreu devido ao emprego da fotografia e a resultante melhora de sensibilidade na observação.

  5. Synthetic generation of spatially high resolution extreme rainfall in Japan using Monte Carlo simulation with AMeDAS analyzed rainfall data sets

    NASA Astrophysics Data System (ADS)

    Haruki, W.; Iseri, Y.; Takegawa, S.; Sasaki, O.; Yoshikawa, S.; Kanae, S.

    2016-12-01

    Natural disasters caused by heavy rainfall occur every year in Japan. Effective countermeasures against such events are important. In 2015, a catastrophic flood occurred in Kinu river basin, which locates in the northern part of Kanto region. The remarkable feature of this flood event was not only in the intensity of rainfall but also in the spatial characteristics of heavy rainfall area. The flood was caused by continuous overlapping of heavy rainfall area over the Kinu river basin, suggesting consideration of spatial extent is quite important to assess impacts of heavy rainfall events. However, the spatial extent of heavy rainfall events cannot be properly measured through rainfall measurement by rain gauges at observation points. On the other hand, rainfall measurements by radar observations provide spatially and temporarily high resolution rainfall data which would be useful to catch the characteristics of heavy rainfall events. For long term effective countermeasure, extreme heavy rainfall scenario considering rainfall area and distribution is required. In this study, a new method for generating extreme heavy rainfall events using Monte Carlo Simulation has been developed in order to produce extreme heavy rainfall scenario. This study used AMeDAS analyzed precipitation data which is high resolution grid precipitation data made by Japan Meteorological Agency. Depth area duration (DAD) analysis has been conducted to extract extreme rainfall events in the past, considering time and spatial scale. In the Monte Carlo Simulation, extreme rainfall event is generated based on events extracted by DAD analysis. Extreme heavy rainfall events are generated in specific region in Japan and the types of generated extreme heavy rainfall events can be changed by varying the parameter. For application of this method, we focused on Kanto region in Japan. As a result, 3000 years rainfall data are generated. 100 -year probable rainfall and return period of flood in Kinu River

  6. Brazil's premier gold province. Part II: geology and genesis of gold deposits in the Archean Rio das Velhas greenstone belt, Quadrilátero Ferrífero

    NASA Astrophysics Data System (ADS)

    Lobato, Lydia; Ribeiro-Rodrigues, Luiz; Vieira, Frederico

    2001-07-01

    Orogenic, gold deposits are hosted by rocks of the Archean Rio das Velhas greenstone belt in the Quadrilátero Ferrífero region, Minas Gerais state, Brazil, one of the major gold provinces in the world. The gold deposits occur at the base of the mafic-ultramafic succession, with the most important orebodies controlled by E-W-striking, strike-slip faults. The main mineralization styles are (1) structurally controlled, sulfide replacement zones in banded iron formation (BIF); (2) disseminated sulfide minerals and gold in hydrothermally altered rocks along shear zones; and (3) auriferous quartz-carbonate-sulfide veins and veinlets in mafic, ultramafic, and felsic volcanic rocks, and also in clastic sedimentary rocks. The most common host rocks for ore are metamorphosed oxide- and carbonate-facies banded iron (± iron-rich metachert) formations (e.g., the Cuiabá, São Bento and Raposos deposits) and the lapa seca unit, which is a local term for intensely carbonatized rock (e.g., the giant Morro Velho mine with >450 t of contained gold). Metabasalts host most of the remaining gold deposits. Mineralogical characteristics and fluid inclusion studies suggest variations in the H2O/CO2 ratio of a low-salinity, near-neutral, reducing, sulfur-bearing, ore fluid. The presence of abundant CH4-rich inclusions is related to reduction of the original H2O-CO2 fluid via interaction with carbonaceous matter in the wallrocks. Oxygen fugacity was close to that of graphite saturation, with variations likely to have been influenced by reaction with the carbonaceous matter. Carbon-rich phyllites and schists, which commonly bound ore-bearing horizons, seem to have played both a physical and chemical role in localizing hydrothermal mineral deposition. Microtextural studies indicate that gold deposition was mainly related to desulfidation reactions, and was paragenetically coeval with precipitation of arsenic-rich iron sulfide minerals. Carbon isotope data are compatible with dissolution of

  7. Diagnostische Präzision der komponentenbasierten vs. der extraktbasierten In-vitro-Diagnostik von Insektengift-Allergien: Auswirkungen auf das klinische Management.

    PubMed

    Seyfarth, Florian; Miguel, Diana; Schliemann, Sibylle; Hipler, Uta-Christina

    2017-05-01

    Die Bestimmung von spezifischen IgE-Antikörpern spielt eine zentrale Bedeutung bei der Diagnostik von Bienen- und Wespengiftallergien. In den letzten Jahren wurden die komponentenbasierte Diagnostik (CRD) eingeführt, die die Bestimmung spezifischer IgE-Antikörper gegen die Allergene Api m 1, Ves v 1, Ves v 5 und Pol d 5 sowie kreuzreaktive Kohlenhydratdeterminanten (CCDs) erlaubt. Hierdurch soll vor allem bei Probanden mit Doppelsensibilisierungen die klinische Relevanz der einzelnen Sensibilisierungen besser beurteilt werden können. Die spezifischen IgE-Antikörper-Bestimmungen an 143 Probanden mit Bienen- und/oder Wespengiftallergie erfolgten mit den extraktbasierten ImmunoCAP®-Allergenen i1 und i3 sowie den ImmunoCAP®-Allergenkomponenten i208-211 und o214 (Api m 1, Ves v 1, Ves v 5, Pol d 5, CCD). Bei Doppelsensibilisierten wurde zusätzlich ein Inhibitionstest durchgeführt. An einem Teilkollektiv der Studienpopulation erfolgten sIgE-Bestimmungen gegen Api m 1, Api m 4, Pol d 5 und Ves v 5 mittels Allergiechip (ISAC®, n  =  44). Die Sensitivität von Ves v 5 bei isolierten Wespengiftallergikern betrug 78,5 %, gemeinsam mit Ves v 1 stieg diese auf 92,3 %. Die Sensitivität von Api m 1 bei isolierten Bienengiftallergikern betrug 25 %. Die komponentenbasierte Diagnostik und Inhibitionstests bei Doppelsensibilisierten lieferten divergente Ergebnisse. Die CRD mittels ISAC®-Allergiechip erbrachte deutliche Unterschiede vor allem im Hinblick auf die Diagnostik von Api m 1 und CCDs. Die CRD bereichert das diagnostische Spektrum, sofern sie nicht allein sondern zusätzlich zu den etablierten Verfahren eingesetzt wird. Sie sollte neben Ves v 5 stets die Bestimmung der IgE-Antikörper gegen Ves v 1 umfassen. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  8. Evaluation of the activity of rheumatoid arthritis in clinical practice. Agreement between self-rated clinimetric evaluation and clinical evaluation with activity indexes: DAS28, CDAI and SDAI.

    PubMed

    Horta-Baas, Gabriel; Pérez Bolde-Hernández, Arturo; Hernández-Cabrera, María Fernanda; Vergara-Sánchez, Imelda; Romero-Figueroa, María Del Socorro

    2017-10-11

    To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with laboratory studies (DAS28 and SDAI) or without them (CDAI). The objective was to analyze the concordance between self-rated clinimetric evaluation and clinimetric evaluation performed by the physician. Analytical cross-sectional study in 126 patients with RA. The agreement was evaluated through the weighted κ coefficient and the Krippendorff's α coefficient. The PAS-II and RAPID-3 significantly correlated with all variables included in the core set of measures recommended by the ACR/EULAR. The agreement between PAS-II and CDAI-SDAI was good (κ: 0.6, α: 0.61-0.62), and moderate with DAS28-ESR (κ: 0.53, α: 0.56). The concordance between RAPID-3 and CDAI-SDAI was moderate (κ: 0.55-0.57, α: 0.50-0.51), and moderate with DAS28-ESR (κ: 0.55, α: 0.53). When categorizing the activity in remission/low activity vs. moderate/severe activity, the agreement was greater with the PAS-II (0.59 vs. 0.34; P=.012). The good concordance between PAS-II and SDAI supports their use in clinical practice, especially if biomarkers of inflammation or the possibility of joint count are not available. However, in order to recommend its routine application in clinical practice, it is necessary to perform longitudinal studies that assess its responsiveness. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  9. Epidemiology of human infection with the novel virus influenza A (H1N1) in the Hospital das Clínicas, São Paulo, Brazil--June-September 2009.

    PubMed

    Schout, Denise; Hajjar, Ludhmila Abrahao; Galas, Filomena Regina Barbosa Gomes; Uip, David Everson; Levin, Anna Sara Shafferman; Caiaffa Filho, Helio Hehl; Sakane, Pedro Takanori; Suslik, Carlos Alberto; Teixeira, Jose Manoel de Camargo; Bonfa, Eloisa; Barone, Antonio Alci; Martins, Milton de Arruda; Boulos, Marcos; Auler, Jose Otavio Costa

    2009-01-01

    The pandemic novel influenza A (H1N1) infection was considered widespread in Brazil on July 16, 2009. Since then, 46,810 cases of acute respiratory syndrome have been reported in Brazil, most of them concentrated in São Paulo. Through September 16, we have confirmed 9,249 cases of novel influenza A H1N1in Brazil, including 699 deaths. The mortality rate observed in Brazil is 0.47/100,000 inhabitants and varies according to region. In this period, São Paulo registered 3733 cases (40.3% of the total) of novel influenza A (H1N1) infection and 327 deaths, reflecting a mortality rate of 0.79/100,000 inhabitants. The Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC) is a reference center for H1N1 cases in São Paulo. During the winter of 2009, 472 patients in this hospital were diagnosed with H1N1 infection; of these, 210 were admitted, and 16 died. To control this pandemic and to provide adequate care for these patients, the Hospital das Clínicas implemented "bundles" including prevention strategies, an epidemiologic surveillance service, availability of fast diagnosis, antiviral treatment and training of staff. The purpose of this manuscript is to describe the epidemiologic features of novel human influenza A (H1N1) infection in the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo during the winter period of the 2009 pandemic.

  10. The Effect of Direct and Indirect Corrective Feedback on Students' Spelling Errors (El efecto de la retroalimentación directa e indirecta sobre los errores de ortografía de los estudiantes)

    ERIC Educational Resources Information Center

    Baleghizadeh, Sasan; Dadashi, Mehdi

    2011-01-01

    The study presented here is an attempt to examine the role of indirect feedback in promoting junior high school students' spelling accuracy in English. It compares the effect of direct feedback with indirect feedback on students' written work dictated by their teacher from their textbooks. Two classes were selected from the Zanjanrood District in…

  11. Assessment of the validity of the 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR) as a disease activity index of rheumatoid arthritis in the efficacy evaluation of 24-week treatment with tocilizumab: subanalysis of the SATORI study.

    PubMed

    Nishimoto, Norihiro; Takagi, Nobuhiro

    2010-12-01

    As tocilizumab (TCZ) greatly inhibits inflammatory markers, methods of evaluating rheumatoid arthritis (RA) disease activity that include inflammatory markers may overestimate the effect of TCZ treatment. We have evaluated the impact of inflammatory markers on the efficacy of TCZ by comparing the efficacy indicated by the 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR) with that indicated by the clinical and simplified disease activity indexes (CDAI and SDAI, respectively) and the American College of Rheumatology (ACR) core set criteria in a double-blind study of TCZ-the SATORI study. The Spearman correlation coefficient between DAS28-ESR and CDAI was comparable between that at week 24 and that at baseline [correlation coefficient at baseline and week 24 was 0.823 (p < 0.0001) and 0.818 (p < 0.0001), respectively]. A large difference between the DAS28 remission rate and CDAI remission rate was observed at week 24. However, these results are comparable to those of a previous study conducted with non-TCZ-treated patients. Moreover, the same results were obtained in the comparison between the DAS28-ESR and SDAI, even though the SDAI includes an inflammatory parameter as a component. These results confirm that the DAS28-ESR has a validity comparable to that of other methods in terms of evaluating the RA treatment efficacy of TCZ, despite its strong inflammatory marker-inhibiting effects.

  12. [Causes of maternal mortality in the Instituto Mexicano del Seguro Social, period 2009-2012].

    PubMed

    Ruíz-Rosas, Roberto Aguli; Cruz-Cruz, Polita Rocío

    2014-01-01

    Introducción: la razón de muerte materna (RMM) ha disminuido lentamente, no obstante que la OMS se propuso reducirla en un 75 % en el período de 1990 a 2015. Por esto es necesario continuar con el análisis de las causas para reforzar e innovar líneas de acción y así disminuir las muertes maternas en nuestro país. Métodos: estudio retrospectivo en el que se incluyeron casos de muerte materna que ocurrieron de 2009 a 2012, por causa directa e indirecta. La información se obtuvo del expediente de muerte materna, el cual es un documento oficial del IMSS. La definición de muerte materna utilizada fue la emitida por la OMS. Las muertes indirectas se agruparon según la décima revisión de la Clasificación Internacional de Enfermedades (CIE-10). Se utilizó estadística descriptiva. Resultados: la RMM en el IMSS ha disminuido en forma lenta pero constante, pues en el 2012 se obtuvo la RMM más baja en la institución (26.4). Sin embargo, la preeclampsia severa-eclampsia y la hemorragia obstétrica ocuparon el primero y segundo lugar. Como causa indirecta, las enfermedades del sistema cardiovascular, y las neoplasias malignas ocuparon los primeros lugares sin subestimar las cifras de las patologías respiratorias, digestivas y endocrinas. Conclusiones: es necesario proseguir con los esfuerzos para disminuir la RMM en todos los niveles de atención médica. Es prioritario continuar con la educación y consejería preconcepcional a mujeres en edad fértil y fortalecer las acciones en la planificación familiar.

  13. 19 CFR 122.74 - Incomplete (pro forma) manifest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OF THE TREASURY AIR COMMERCE REGULATIONS Documents Required for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial...

  14. 17 CFR 210.8-05 - Pro forma financial information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... reflecting the combined operations of the entities for the latest fiscal year and interim period, if any; or... reflecting the combined operations of the entities for the latest fiscal year and interim period, if any, are...

  15. Utilice en forma segura los productos con cebo para roedores

    EPA Pesticide Factsheets

    Si se usan de manera inadecuada, los productos con veneno para ratas y ratones podrían hacerle daño a usted, a sus hijos o a sus mascotas. Siempre que use pesticidas lea la etiqueta del producto y siga todas las indicaciones.

  16. Alternaria section Alternaria: Species, formae speciales or pathotypes?

    PubMed Central

    Woudenberg, J.H.C.; Seidl, M.F.; Groenewald, J.Z.; de Vries, M.; Stielow, J.B.; Thomma, B.P.H.J.; Crous, P.W.

    2015-01-01

    The cosmopolitan fungal genus Alternaria consists of multiple saprophytic and pathogenic species. Based on phylogenetic and morphological studies, the genus is currently divided into 26 sections. Alternaria sect. Alternaria contains most of the small-spored Alternaria species with concatenated conidia, including important plant, human and postharvest pathogens. Species within sect. Alternaria have been mostly described based on morphology and / or host-specificity, yet molecular variation between them is minimal. To investigate whether the described morphospecies within sect. Alternaria are supported by molecular data, whole-genome sequencing of nine Alternaria morphospecies supplemented with transcriptome sequencing of 12 Alternaria morphospecies as well as multi-gene sequencing of 168 Alternaria isolates was performed. The assembled genomes ranged in size from 33.3–35.2 Mb within sect. Alternaria and from 32.0–39.1 Mb for all Alternaria genomes. The number of repetitive sequences differed significantly between the different Alternaria genomes; ranging from 1.4–16.5 %. The repeat content within sect. Alternaria was relatively low with only 1.4–2.7 % of repeats. Whole-genome alignments revealed 96.7–98.2 % genome identity between sect. Alternaria isolates, compared to 85.1–89.3 % genome identity for isolates from other sections to the A. alternata reference genome. Similarly, 1.4–2.8 % and 0.8–1.8 % single nucleotide polymorphisms (SNPs) were observed in genomic and transcriptomic sequences, respectively, between isolates from sect. Alternaria, while the percentage of SNPs found in isolates from different sections compared to the A. alternata reference genome was considerably higher; 8.0–10.3 % and 6.1–8.5 %. The topology of a phylogenetic tree based on the whole-genome and transcriptome reads was congruent with multi-gene phylogenies based on commonly used gene regions. Based on the genome and transcriptome data, a set of core proteins was extracted, and primers were designed on two gene regions with a relatively low degree of conservation within sect. Alternaria (96.8 and 97.3 % conservation). Their potential discriminatory power within sect. Alternaria was tested next to nine commonly used gene regions in sect. Alternaria, namely the SSU, LSU, ITS, gapdh, rpb2, tef1, Alt a 1, endoPG and OPA10-2 gene regions. The phylogenies from the two gene regions with a relatively low conservation, KOG1058 and KOG1077, could not distinguish the described morphospecies within sect. Alternaria more effectively than the phylogenies based on the commonly used gene regions for Alternaria. Based on genome and transcriptome comparisons and molecular phylogenies, Alternaria sect. Alternaria consists of only 11 phylogenetic species and one species complex. Thirty-five morphospecies, which cannot be distinguished based on the multi-gene phylogeny, are synonymised under A. alternata. By providing guidelines for the naming and identification of phylogenetic species in Alternaria sect. Alternaria, this manuscript provides a clear and stable species classification in this section. PMID:26951037

  17. 17 CFR 210.8-05 - Pro forma financial information.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... AND CONSERVATION ACT OF 1975 Article 8 Financial Statements of Smaller Reporting Companies § 210.8-05..., and should include the following: (1) If the transaction was consummated during the most recent fiscal... transaction has occurred or is probable after the date of the most recent balance sheet required by § 210.8-02...

  18. 17 CFR 210.8-05 - Pro forma financial information.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... AND CONSERVATION ACT OF 1975 Article 8 Financial Statements of Smaller Reporting Companies § 210.8-05..., and should include the following: (1) If the transaction was consummated during the most recent fiscal... transaction has occurred or is probable after the date of the most recent balance sheet required by § 210.8-02...

  19. 17 CFR 210.8-05 - Pro forma financial information.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... AND CONSERVATION ACT OF 1975 Article 8 Financial Statements of Smaller Reporting Companies § 210.8-05..., and should include the following: (1) If the transaction was consummated during the most recent fiscal... transaction has occurred or is probable after the date of the most recent balance sheet required by § 210.8-02...

  20. Evaluation of the Uniform Field Distortions Produced by a Toroidal Dielectric Body / Novērtējums Viendabīga Elektriskā Lauka Izkropļojumiem, Kurus Rada Toroīda Formas Dielektrisks Ķermenis

    NASA Astrophysics Data System (ADS)

    Krasnitsky, Y. A.; Popov, A. E.; Kalnacs, A.

    2015-08-01

    Distortions of the structure of a uniform electric field when a dielectric body with a toroidal shape is placed in it are considered in the quasi-static approximation. The rate of distortion is proposed to estimate through the effective permittivity of toroid determined by solving the corresponding boundary value problem. Some numerical estimates obtained using specially developed software in the language of Matlab are given. Darbā apskatīts kvazi-statisks tuvinājums viendabīga elektriskā lauka izkropļojumiem gadījumos, kad tajā tiek ievietots dielektrisks toroīda formas ķermenis. Izkropļojumu apmēru tiek piedāvāts novērtēt ar toroīda efektīvo caurlaidību, kas tiek noteikta, atrisinot atbilstošo robežvērtību uzdevumu. Tiek doti skaitliski novērtējumi, kas iegūti, lietojot speciāli valodā Matlab izstrādātu programmatūru.

  1. Vernetztes Lernen: Eine Unterrichtseinheit mit Heinrich von Kleists Erzahlung "Das Erdbeben in Chili" und Crista Wolfs Roman "Kein Ort. Nirgends" (Networked Learning: An Instructional Unit with Heinrich von Kleist's Story "The Earthquake in Chile" and Christa Wolf's Novel "No Place, No Where").

    ERIC Educational Resources Information Center

    Eidecker, Martina Elisabeth

    1999-01-01

    Presents an instructional model, using Kleist's story "Das Erdbeben in Chili" and Christa Wolf's novel Kei Ort. Nirgends" as a basis. The model clearly distinguishes itself from quantitative models and mediates solid literary knowledge through an inductive approach. Learning takes place in a multidimensional space that makes possible multiple…

  2. The Astronomy Club of Araranguá: Educating Science Teachers as Science Communicators. (Breton Title: Clube de Astronomia de AraranguÁ: a Formação de Professores de Ciências Como Divulgadores Científicos. ) Club de Astronomía de Araranguá: la Formación del Profesorado Como Comunicadores de la Ciencia

    NASA Astrophysics Data System (ADS)

    Damasio, Felipe; Allain, Olivier; Antunes Rodrigues, Adriano

    2013-07-01

    The study reported in this work takes place since 2009 at the Federal Institute of Education, Science and Technology of Santa Catarina, Campus Araranguá. Our main goal is to help form teachers, training undergraduate students in Natural Sciences with specialization in Physics as science communicators, as well as to promote actions of broader scientific popularization in the region of the town of Araranguá through an Astronomy Club called CA2. Among the actions of scientific popularization that the students promote are: video production, radio broadcasts, lectures, nightly observations, preparation and exhibition of posters, physics teaching for children, continuing education activities for teachers and regular physics teaching using Astronomy as a theme. The Club's teacher education and scientific dissemination work is based on the Theory of Meaningful Learning, always trying to reach the student's predisposition to learn and produce potentially meaningful material, the two essential conditions for meaningful learning to occur. O estudo que este trabalho relata ocorre desde 2009 no Instituto Federal de Educação, Ciência e Tecnologia de Santa Catarina, campus Araranguá. Nele procura-se formar divulgadores científicos durante a formação inicial de docentes do curso de Licenciatura em Ciências da Natureza com habilitação em Física, além de promover ações de divulgação científica para o público geral da região da cidade de Araranguá por meio de um Clube de Astronomia chamado CA² (Clube de Astronomia de Araranguá). Entre as ações de divulgação científica que os licenciandos promovem estão: produção de vídeos, programas de rádio, palestras, observações noturnas, confecção e exposição de pôsteres, ensino de física para crianças, formação continuada de professores em atividades e ensino de Física regular utilizando a Astronomia como tema gerador. O trabalho de formação docente e divulgação científica do Clube fundamenta

  3. Mapping health assessment questionnaire disability index (HAQ-DI) score, pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) onto the EuroQol-5D (EQ-5D) utility score with the KORean Observational study Network for Arthritis (KORONA) registry data.

    PubMed

    Kim, Hye-Lin; Kim, Dam; Jang, Eun Jin; Lee, Min-Young; Song, Hyun Jin; Park, Sun-Young; Cho, Soo-Kyung; Sung, Yoon-Kyoung; Choi, Chan-Bum; Won, Soyoung; Bang, So-Young; Cha, Hoon-Suk; Choe, Jung-Yoon; Chung, Won Tae; Hong, Seung-Jae; Jun, Jae-Bum; Kim, Jinseok; Kim, Seong-Kyu; Kim, Tae-Hwan; Kim, Tae-Jong; Koh, Eunmi; Lee, Hwajeong; Lee, Hye-Soon; Lee, Jisoo; Lee, Shin-Seok; Lee, Sung Won; Park, Sung-Hoon; Shim, Seung-Cheol; Yoo, Dae-Hyun; Yoon, Bo Young; Bae, Sang-Cheol; Lee, Eui-Kyung

    2016-04-01

    The aim of this study was to estimate the mapping model for EuroQol-5D (EQ-5D) utility values using the health assessment questionnaire disability index (HAQ-DI), pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) in a large, nationwide cohort of rheumatoid arthritis (RA) patients in Korea. The KORean Observational study Network for Arthritis (KORONA) registry data on 3557 patients with RA were used. Data were randomly divided into a modeling set (80 % of the data) and a validation set (20 % of the data). The ordinary least squares (OLS), Tobit, and two-part model methods were employed to construct a model to map to the EQ-5D index. Using a combination of HAQ-DI, pain VAS, and DAS28, four model versions were examined. To evaluate the predictive accuracy of the models, the root-mean-square error (RMSE) and mean absolute error (MAE) were calculated using the validation dataset. A model that included HAQ-DI, pain VAS, and DAS28 produced the highest adjusted R (2) as well as the lowest Akaike information criterion, RMSE, and MAE, regardless of the statistical methods used in modeling set. The mapping equation of the OLS method is given as EQ-5D = 0.95-0.21 × HAQ-DI-0.24 × pain VAS/100-0.01 × DAS28 (adjusted R (2) = 57.6 %, RMSE = 0.1654 and MAE = 0.1222). Also in the validation set, the RMSE and MAE were shown to be the smallest. The model with HAQ-DI, pain VAS, and DAS28 showed the best performance, and this mapping model enabled the estimation of an EQ-5D value for RA patients in whom utility values have not been measured.

  4. Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery: combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds

    PubMed Central

    Nikiphorou, Elena; Norton, Sam; Young, Adam; Carpenter, Lewis; Dixey, Josh; Walsh, David Andrew; Kiely, Patrick

    2016-01-01

    Objectives To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Methods Health Assessment Questionnaire (HAQ) disability scores were collected from two longitudinal early RA inception cohorts in routine care; Early Rheumatoid Arthritis Study and Early Rheumatoid Arthritis Network from 1986 to 2012. The incidence of major and intermediate orthopaedic surgical episodes over 25 years was collected from national data sets. Disease activity was categorised by mean disease activity score (DAS28) annually between years 1 and 5; remission (RDAS≤2.6), low (LDAS>2.6–3.2), low-moderate (LMDAS≥3.2–4.19), high-moderate (HMDAS 4.2–5.1) and high (HDAS>5.1). Results Data from 2045 patients were analysed. Patients in RDAS showed no HAQ progression over 5 years, whereas there was a significant relationship between rising DAS28 category and HAQ at 1 year, and the rate of HAQ progression between years 1 and 5. During 27 986 person-years follow-up, 392 intermediate and 591 major surgeries were observed. Compared with the RDAS category, there was a significantly increased cumulative incidence of intermediate surgery in HDAS (OR 2.59 CI 1.49 to 4.52) and HMDAS (OR 1.8 CI 1.05 to 3.11) categories, and for major surgery in HDAS (OR 2.48 CI 1.5 to 4.11), HMDAS (OR 2.16 CI 1.32 to 3.52) and LMDAS (OR 2.07 CI 1.28 to 3.33) categories. There was no significant difference in HAQ progression or orthopaedic episodes between RDAS and LDAS categories. Conclusions There is an association between disease activity and both poor function and long-term orthopaedic episodes. This illustrates the far from benign consequences of persistent moderate disease activity, and supports European League Against Rheumatism treat to target recommendations to secure low disease activity or remission in all patients. PMID:26979104

  5. Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery: combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds.

    PubMed

    Nikiphorou, Elena; Norton, Sam; Young, Adam; Carpenter, Lewis; Dixey, Josh; Walsh, David Andrew; Kiely, Patrick

    2016-12-01

    To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Health Assessment Questionnaire (HAQ) disability scores were collected from two longitudinal early RA inception cohorts in routine care; Early Rheumatoid Arthritis Study and Early Rheumatoid Arthritis Network from 1986 to 2012. The incidence of major and intermediate orthopaedic surgical episodes over 25 years was collected from national data sets. Disease activity was categorised by mean disease activity score (DAS28) annually between years 1 and 5; remission (RDAS≤2.6), low (LDAS>2.6-3.2), low-moderate (LMDAS≥3.2-4.19), high-moderate (HMDAS 4.2-5.1) and high (HDAS>5.1). Data from 2045 patients were analysed. Patients in RDAS showed no HAQ progression over 5 years, whereas there was a significant relationship between rising DAS28 category and HAQ at 1 year, and the rate of HAQ progression between years 1 and 5. During 27 986 person-years follow-up, 392 intermediate and 591 major surgeries were observed. Compared with the RDAS category, there was a significantly increased cumulative incidence of intermediate surgery in HDAS (OR 2.59 CI 1.49 to 4.52) and HMDAS (OR 1.8 CI 1.05 to 3.11) categories, and for major surgery in HDAS (OR 2.48 CI 1.5 to 4.11), HMDAS (OR 2.16 CI 1.32 to 3.52) and LMDAS (OR 2.07 CI 1.28 to 3.33) categories. There was no significant difference in HAQ progression or orthopaedic episodes between RDAS and LDAS categories. There is an association between disease activity and both poor function and long-term orthopaedic episodes. This illustrates the far from benign consequences of persistent moderate disease activity, and supports European League Against Rheumatism treat to target recommendations to secure low disease activity or remission in all patients. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  6. Composition of grain and forage from insect-protected and herbicide-tolerant corn, MON 89034 × TC1507 × MON 88017 × DAS-59122-7 (SmartStax), is equivalent to that of conventional corn (Zea mays L.).

    PubMed

    Lundry, Denise R; Burns, J Austin; Nemeth, Margaret A; Riordan, Susan G

    2013-02-27

    Monsanto Company and Dow AgroSciences LLC have developed the combined-trait corn product MON 89034 × TC1507 × MON 88017 × DAS-59122-7 (SmartStax, a registered trademark of Monsanto Technology LLC). The combination of four biotechnology-derived events into a single corn product (stacking) through conventional breeding provides broad protection against lepidopteran and corn rootworm insect pests as well as tolerance to the glyphosate and glufosinate-ammonium herbicide families. The purpose of the work described here was to assess whether the nutrient, antinutrient, and secondary metabolite levels in grain and forage tissues of the combined-trait product are comparable to those in conventional corn. Compositional analyses were conducted on grain and forage from SmartStax, a near-isogenic conventional corn hybrid (XE6001), and 14 conventional reference hybrids, grown at multiple locations across the United States. No statistically significant differences between SmartStax and conventional corn were observed for the 8 components analyzed in forage and for 46 of the 52 components analyzed in grain. The six significant differences observed in grain components (p < 0.05) were assessed in context of the natural variability for that component. These results demonstrate that the stacked product, SmartStax, produced through conventional breeding of four single-event products containing eight proteins, is compositionally equivalent to conventional corn, as previously demonstrated for the single-event products.

  7. Lactic acid microbiota identification in water, raw milk, endogenous starter culture, and fresh Minas artisanal cheese from the Campo das Vertentes region of Brazil during the dry and rainy seasons.

    PubMed

    Castro, R D; Oliveira, L G; Sant'Anna, F M; Luiz, L M P; Sandes, S H C; Silva, C I F; Silva, A M; Nunes, A C; Penna, C F A M; Souza, M R

    2016-08-01

    Minas artisanal cheese, produced in the Campo das Vertentes region of Brazil, is made from raw milk and endogenous starter cultures. Although this cheese is of great historical and socioeconomic importance, little information is available about its microbiological and physical-chemical qualities, or about its beneficial microbiota. This work was aimed at evaluating the qualities of the cheese and the components used for its production, comparing samples collected during the dry and rainy seasons. We also conducted molecular identification and isolated 50 samples of lactic acid bacteria from cheese (n=21), water (n=3), raw milk (n=9), and endogenous starter culture (n=17). The microbiological quality of the cheese, water, raw milk, and endogenous starter culture was lower during the rainy period, given the higher counts of coagulase-positive Staphylococcus and total and thermotolerant coliforms. Enterococcus faecalis was the lactic acid bacteria isolated most frequently (42.86%) in cheese samples, followed by Lactococcus lactis (28.57%) and Lactobacillus plantarum (14.29%). Lactobacillus brevis (5.88%), Enterococcus pseudoavium (5.88%), Enterococcus durans (5.88%), and Aerococcus viridans (5.88%) were isolated from endogenous starter cultures and are described for the first time in the literature. The lactic acid bacteria identified in the analyzed cheeses may inhibit undesirable microbiota and contribute to the safety and flavor of the cheese, but this needs to be evaluated in future research.

  8. Comparison of grain from corn rootworm resistant transgenic DAS-59122-7 maize with non-transgenic maize grain in a 90-day feeding study in Sprague-Dawley rats.

    PubMed

    He, X Y; Huang, K L; Li, X; Qin, W; Delaney, B; Luo, Y B

    2008-06-01

    DAS-59122-7 (59122) is a transgenic maize (Zea mays L.) that contains genes encoding Cry34Ab1 and Cry35Ab1 proteins from Bacillus thuringiensis Berliner strain 149B1 and phosphinothricin acetyltransferase (PAT) protein from Streptomyces viridochromogenes. Expression of these proteins in planta confers resistance to corn rootworms and other Coleopteran parasites and tolerance to herbicides containing glufosinate ammonium, respectively. In the current study, processed flours from 59122 maize grain or its near isogenic control line (091) were used at two concentrations (50% and 70% wt/wt) to produce diets that were fed to rats for 90 days in accordance with Chinese toxicology guidelines (GB15193.13-2003). A commercial AIN93G diet was used as an additional negative control. No significant differences in body weight and feed utilization were observed between rats consuming diets formulated with 59122 and 091 Control corn. Statistical differences (p<0.05) were observed in certain hematology and serum chemistry response variables between rats consuming diets formulated with 59122 or 091 Control flour compared to AIN93G diet. However, the mean value of these response variables in the 59122 groups were not statistically different from those observed in diets formulated with corresponding high and low concentrations of the flour from the 091 Control maize grain. Therefore, the statistical differences were considered to be related to consumption of diets containing high concentrations of maize flour (compared to AIN93G diets) regardless of source rather than to consumption of flour from 59122 maize grain. The results from this study demonstrated that 59122 maize grain is as safe as non-transgenic maize grain.

  9. Das deutsche Adverbialsystem (The German Adverbial System)

    ERIC Educational Resources Information Center

    Droescher, W. O.

    1974-01-01

    Describes the surface structure of German adverbs proceeding from the standpoint of dependence-valence grammar. On the basis of their meaning, adverbs are classified as modal, temporal and locational. (Text is in German.) (IFS/WGA)

  10. Kanban - der Weg ist das Ziel

    NASA Astrophysics Data System (ADS)

    Aull, Florian; Berlak, Joachim; Dickmann, Eva; Dickmann, Philipp; Fischäder, Holm; Gerlach, Joachim; Henneberg, Jens; Kapalla, Klaus; Kress, Oliver; Kuttler, Robert; Schneider, Herfried M.; Schürle, Philipp; Stellpflug, Franz-Josef; Wannenwetsch, Ralph; Wulz, Johannes; Zäh, Michael F.

    Wenn man aktuell Produktionsbereiche in Deutschland und Europa besucht, fallen im Zusammenhang mit modernen Produktionsmethoden immer öfter die Begriffe Kanban (jap. Karte, Signal) und Pull-Produktion, und dies nicht ohne Stolz, da diese mit dem schillernden Vorbild des Toyota Produktionssystems in Zusammenhang stehen. Tatsächlich ist Kanban ein integraler Bestandteil moderner Produktionssysteme. Blickt man aber im Rahmen von Prozessanalysen hinter die Fassaden", d. h. in die tägliche Praxis der Arbeitsprozesse, wird man schnell desillusioniert - die viel gepriesenen klassischen Kanban-Regeln werden im Tagesgeschäft nicht eingehalten.

  11. Physikgeschichte Das Rätsel bleibt

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    2002-05-01

    Die jüngst erfolgte Veröffentlichung von Dokumenten aus dem Privatarchiv der Familie Bohr [1] über den geheimnisumwitterten Besuch von Werner Heisenberg in Kopenhagen im September 1941 hat in den deutschen Medien große Resonanz gefunden [2]. Tatsächlich verraten uns die jetzt veröffentlichten Dokumente sehr viel mehr über die Zeit ihres Entstehens als über den Besuch selbst.

  12. Das Gluck des Kindes (The Child's Happiness).

    ERIC Educational Resources Information Center

    Fuhr, Thomas

    2002-01-01

    Examines the pedagogical discourse on the child's happiness, the structure of happiness, empirical findings on a child's happiness. Addresses the problems of research on children's needs. Concludes that happiness also includes feelings of joy or sorrow and that pedagogical judgments should take into account these feelings. (CAJ)

  13. Das Gluck des Lehrers (The Teacher's Happiness).

    ERIC Educational Resources Information Center

    Higgins, Christopher

    2002-01-01

    Argues that the ethics of teaching concerns the relationship between the teaching and the good life. Uses Bernard Williams' ethics/morality distinction. Connects the question of "why teach?" with the question "how should I live?" Asks why the practice of teaching is worth it in terms of self growth and monetary gains. (CAJ)

  14. Internationale Schulreformtendenzen und das Problem der Lehrerausbildung

    NASA Astrophysics Data System (ADS)

    Kupisiewicz, Czeslaw

    1982-09-01

    The main theme of this article is that the socio-economic and educational changes which have occurred in industrialized countries in the past 20 to 25 years necessitate a thorough reform of the present system of teacher education. The first group of such changes includes the information explosion, greater occupational mobility, the growing significance and increasing role of the sciences, the development of the mass media, higher educational aspirations, technical development, the acceleration of the psycho-physical development of children and youth, and the injurious effects of the uncontrolled development of the constantly changing civilisation (deterioration of the human environment, diseases caused by the effects of civilisation, etc.). In the face of these changes, teachers must not remain indifferent and teacher education systems have to take them into account. Within the second group of changes influencing the content and methods of teacher education, the most important is the generalisation of education at the pre-school, primary and secondary school levels and also at the university level. As a result, education in many types of school and at ever higher levels has lost the elitist character it still had, not so long ago, and has become a mass activity. This has considerably affected teachers' work and, necessarily, also the work of the teacher education systems. In present-day schools it is necessary to emphasize not only the transmission of knowledge of the `know that' type, as was done in the past, but also problem-solving, independent individual and group work, etc., which will enable children and young people to acquire `know-how' and `know-why'. This must also be reflected in teacher education. In order to adapt the teacher education systems to the requirements of the changing society, a reform of the goals, contents and methods of the system will have to be prepared and implemented as a prerequisite and starting point for a global reform of the entire education system.

  15. Determinação da massa de júpiter a partir das órbitas de seus satélites: um experimento didático

    NASA Astrophysics Data System (ADS)

    Schlickmann, M. S.; Saito, R. K.; Becker, D. A.; Rezende, M. F., Jr.; Cid Fernandes, R.

    2003-08-01

    Este trabalho apresenta o roteiro piloto de uma prática observacional em astronomia, junto com os primeiros resultados obtidos nesta fase de implementacão. O projeto, que será executado em duas etapas, visa introduzir noções de Astronomia a alunos do Ensino Médio e iniciantes nos cursos de Física. O experimento consiste em medir as órbitas dos satélites Galileanos e, a partir da análise dos dados coletados, verificar a validade da Lei das órbitas de Kepler, determinando a massa do planeta Júpiter. Em uma primeira etapa, as observações serão feitas utilizando um telescópio Meade LX200 10" e câmera CCD para obter uma seqüência de imagens do planeta, que possibilitará medir o movimento de seus satélites. A segunda etapa terá início a partir do funcionamento do telescópio em modo robótico, com a possibilidade de observações via internet por instituições de ensino. Para o desenvolvimento deste experimento foram inicialmente coletadas várias imagens de Júpiter obtidas com os instrumentos citados acima. Estas imagens serviram como base para confecção dos roteiros para a experiência no nível médio e superior. Os roteiros serão inicialmente apresentados em uma home-page. Nela também se buscará uma contextualização histórica da experiência bem como o estabelecimento de relações com professores e alunos, propostas metodológicas e a disponibilização dos programas computacionais necessários para a utilização "on-line" pelos usuários. O projeto conta com apoio da Fundação VITAE.

  16. Importance of land use update during the calibration period and simulation of water balance response to land use change in the upper Rio das Mortes Catchment (Cerrado Biome, Central-Western Brazil)

    NASA Astrophysics Data System (ADS)

    Lamparter, Gabriele; Kovacs, Kristof; Nobrega, Rodolfo; Gerold, Gerhard

    2015-04-01

    Changes in the hydrological balance and following degradation of the water ecosystem services due to large scale land use changes are reported from agricultural frontiers all over the world. Traditionally, hydrological models including vegetation and land use as a part of the hydrological cycle use a fixed distribution of land use for the calibration period. We believe that a meaningful calibration - especially when investigating the effects of land use change on hydrology - demands the inclusion of land use change during the calibration period into the calibration procedure. The SWAT (Soil and Water Assessment Tool) model is a process-based, semi-distributed model calculating the different components of the water balance. The model bases on the definition of hydrological response units (HRUs) which are based on soil, vegetation and slope distribution. It specifically emphasises the role of land use and land management on the water balance. The Central-Western region of Brazil is one of the leading agricultural frontiers, which experienced rapid and radical deforestation and agricultural intensification in the last 40 years (from natural Cerrado savannah to cattle grazing to intensive corn and soya cropland). The land use history of the upper Rio das Mortes catchment (with 17500 km²) is reasonably well documented since the 1970th. At the same time there are almost continuous climate and runoff data available for the period between 1988 and 2011. Therefore, the work presented here shows the model calibration and validation of the SWAT model with the land use update function for three different periods (1988 to 1998, 1998 to 2007 and 2007 to 2011) in comparison with the same calibration periods using a steady state land use distribution. The use of the land use update function allows a clearer identification which changes in the discharge are due to climatic variability and which are due to changes in the vegetation cover. With land use update included into the

  17. Performance of lactating dairy cows fed corn as whole plant silage and grain produced from genetically modified corn containing event DAS-59122-7 compared to a nontransgenic, near-isogenic control.

    PubMed

    Brouk, M J; Cvetkovic, B; Rice, D W; Smith, B L; Hinds, M A; Owens, F N; Iiams, C; Sauber, T E

    2011-04-01

    The nutritional equivalency of grain plus whole plant silage from genetically modified corn plants containing the DAS-59122-7 (59122) event expressing the Cry34Ab1 and Cry35Ab1 proteins to grain and silage from a near-isogenic corn hybrid without this trait (control) was assessed using lactating dairy cows. Corn plants with event 59122 are resistant to western corn rootworm and tolerant to the herbicide active ingredient glufosinate-ammonium. Effects on feed intake, milk production, and milk composition were determined. The 59122 grain and the control grain were produced in 2005 from isolated plots in Richland, Iowa. Whole plant corn silage for the 59122 and control treatments were grown in isolated plots at the Kansas State University Dairy Center and ensiled in Ag-Bags. Thirty lactating Holstein cows blocked by lactation number, day of lactation, and previous energy-corrected milk production were used in a switchback design. All cows were fed diets that contained 22.7% grain plus 21.3% whole plant silage from either the 59122 or the control hybrid, in addition to 21% wet corn gluten feed, 12.3% protein mix, 8.0% whole cottonseed, and 14.7% alfalfa hay. Each period of the switchback trial included 2 wk for diet adjustment followed by 4 wk for data and sample collection. Milk samples (a.m. and p.m.) collected from 2 consecutive milkings of each collection wk were analyzed for fat, protein, lactose, solids-not-fat, milk urea nitrogen, and somatic cell count. Percentages of milk fat, protein, lactose, and solids-not-fat were not affected by dietary treatment. Yields of milk, 4% fat-corrected milk, energy-corrected milk, solids-corrected milk, and the concentrations and yields of milk fat, milk protein, milk solids, and milk lactose were not significantly different between treatments. Efficiencies of milk, fat-corrected milk, energy-corrected milk, and solids-corrected milk production also were not different when cows were fed crops from 59122 than when they were fed

  18. Screening for pulmonary tuberculosis in Teresópolis, RJ, Brazil: the search for respiratory symptomatic patients in emergency service of "Hospital das Clínicas de Teresópolis Costantino Ottaviano, Fundação Educacional Serra dos Orgãos".

    PubMed

    Siqueira-Batista, Rodrigo; Gomes, Andréia Patrícia; Bisaglia, Joana B; Borlot, Paulo Estevão W; D'avila Junior, Heraldo X; Faria, Carolina Gonçalves P P de; Braga, Bernardo D; Bezerra, Tiago S; Cedrola, Juan Pedro V; Almeida, Guilherme C; Couto, Lílian S; Nacif, Marcelo; Crivano, Elvira

    2005-01-01

    The aim of the present study was to investigate the detection percentage of tuberculosis among patients that are respiratory symptomatic (TB suspects). In this work, we present the preliminary results of research carried out at "Hospital das Clínicas de Teresópolis Costantino Ottaviano da Fundacao Educacional Serra dos Orgãos (FESO)" from November 2003 to April 2004. Among the 40 respiratory symptomatic individuals identified and referred to the Tuberculosis Control Program in Teresópolis , two (5.0%) were characterized as smear-positive. These results confirm reports in the literature and underscore the need for and importance of this strategy.

  19. The Universe in a Box: Introduction to the Study of Astronomy in the Initial Formation of Physics Teachers. (Spanish Title: El Universo Representado en Una Caja: Introducción al Estudio de la Astronomía en la Formación Inicial de Profesores de Física.) O Universo Representado em Uma Caixa: Introdução ao Estudo da Astronomia NA Formação Inicial de Professores de Física

    NASA Astrophysics Data System (ADS)

    Longhini, Marcos Daniel

    2009-07-01

    modelos de universo que os participantes possuíam. Os resultados, que foram categorizados em universo miscelânea, geocêntrico, heliocêntrico e acêntrico, foram analisados qualitativamente. São apontadas as análises da atividade na ótica dos participantes, além de tecidas considerações sobre seu emprego como recurso ao ensino de Astronomia e na formação docente.

  20. Amelia/ectromelia in association with scoliosis in three commercial layer hens (Gallus gallus forma domestica).

    PubMed

    Ruble, Randall; Silverman, Sam; Pisenti, Jacqueline; Wakenell, Patricia

    2002-10-01

    Three wingless "healthy" pullet hens were serendipitously discovered at a grow-out facility for an egg-production ranch. Two of the birds were amelic and one was ectromelic. The defect in these chickens differs from the previously reported wingless mutations in that all three affected birds also had scoliosis. The birds also differed from previously reported scolitic mutant chickens in that they were wingless. Although the combination of amelia and scoliosis has been reported in humans, this is the first report of the combination in an animal species.

  1. Molecular Characterization of FT and FD Homologs from Eriobotrya deflexa Nakai forma koshunensis

    PubMed Central

    Zhang, Ling; Yu, Hao; Lin, Shunquan; Gao, Yongshun

    2016-01-01

    In angiosperms, regulation of flowering is a vital process for successful reproduction. To date, the molecular mechanism of flowering is well-studied in the model plant, Arabidopsis, in which key genes such as FLOWERING LOCUST (FT) or FD have been identified to regulate flowering. However, the flowering mechanisms are still largely unknown in fruit trees like loquat. To this end, we first cloned one FT- and two FD-like genes from the loquat (Eriobotrya deflexa Nakai f. koshunensis) and referred to as EdFT, EdFD1, and EdFD2, respectively. Phylogenetic analysis has shown that EdFT, EdFD1, and EdFD2 are conserved during the evolution process. EdFT is mainly expressed in reproductive tissues (e.g., flower buds, flowers, and fruits), while EdFD1 and EdFD2 are mainly expressed in apical buds including leaf buds and flower buds. EdFT is localized in the whole cell, while EdFD1 or EdFD2 is localized in the nucleus. Ectopic expression of EdFT, EdFD1, and EdFD2 in Arabidopsis results in early flowering. In addition, we have also revealed that the EdFT interacts with both EdFD1 and EdFD2. Overall, these data suggest that the EdFT, EdFD1, and EdFD2 are the functional homologs of FT and FD, respectively, which might act together to regulate loquat flowering through a similar mechanism found in Arabidopsis. PMID:26834775

  2. 17 CFR 229.914 - (Item 914) Pro forma financial statements: selected financial data.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the information required by Item 301 of Regulation S-K, Selected Financial Data (§ 229.301), and Item... to be included in a roll-up transaction provide: Ratio of earnings to fixed charges, cash and cash... Supplementary Financial Information are required to be provided. Additional or other information should...

  3. 17 CFR 229.914 - (Item 914) Pro forma financial statements: selected financial data.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... the later of the end of the most recent fiscal year or the latest interim period; (2) Statement of... fiscal year and the latest interim period; (3) Statement of cash flows for the most recent fiscal year and the latest interim period; and (4) Book value per share as of the later of the end of the most...

  4. Companion Guides for Lesson Planning: A Planning Template and the Lesson Plan Pro Forma

    ERIC Educational Resources Information Center

    Pang, May

    2016-01-01

    Jason Anderson's proposal, in "ELT Journal" (2015), for an affordance-based approach to lesson planning raises important issues in teacher education. However, his arguments against the role of planned outcomes in favour of an affordance-based focus using learning opportunities as units of planning fail to acknowledge the complexities…

  5. Companion Guides for Lesson Planning: A Planning Template and the Lesson Plan Pro Forma

    ERIC Educational Resources Information Center

    Pang, May

    2016-01-01

    Jason Anderson's proposal, in "ELT Journal" (2015), for an affordance-based approach to lesson planning raises important issues in teacher education. However, his arguments against the role of planned outcomes in favour of an affordance-based focus using learning opportunities as units of planning fail to acknowledge the complexities…

  6. 47 CFR 1.224 - Motion to proceed in forma pauperis.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Section 1.224 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Hearing... at stake in the proceeding; or (2) An intervenor in a hearing proceeding who is in a position to... activities and purposes of the organization; a current balance sheet and profit and loss statement; facts...

  7. Literatura chicana: Vida en busca de forma (Chicano Literature: Life in Search of Form).

    ERIC Educational Resources Information Center

    Rivera, Tomas

    The Chicano culture is searching for appropriate expression in art forms and literature. The Chicano novel and essay, often written in English, seem directed toward the North American public. The short story is the most varied in viewpoint and most versatile in form. Poetry captures the Chicano sensitivity. It is almost impossible to note the…

  8. Common Geometry Shapes/Formas Geometricas: An Introductory-English Lesson & Introductory Spanish Lesson.

    ERIC Educational Resources Information Center

    Jaramillo, James A.; Solano, Angele

    A lesson plan for first-grade children beginning to learn English describes an activity using manipulatives and visual aids to develop recognition of three geometric shapes (circle, square, rectangle), their names, and a few additional words in English (e.g., "bag,""table,""door"). Students are grouped at tables of four to six and provided with…

  9. Astronomy in High School: Using a Mini-Planetarium to Understand Details of the Apparent Movement of Stars. (Spanish Title: Astronomía en la Escuela Secundaria: Comprendiendo los Detalles del Movimiento Aparente de Las Estrellas con un Miniplanetario.) Astronomia no Ensino Médio: Compreendendo Detalhes do Movimento Aparente das Estrelas com um Miniplanetário

    NASA Astrophysics Data System (ADS)

    dos Santos Leão, Demetrius

    2013-07-01

    en la comprensión de estas cuestiones y demostraron un gran interés por esta metodología. O objetivo deste artigo é apresentar parte dos resultados obtidos com a intervenção feita como projeto da dissertação de mestrado do autor, que consistiu no desenvolvimento de um conjunto de aulas de Astronomia, com alunos do 1º Ano do Ensino Médio de uma escola da rede privada do Distrito Federal (Brasília, Brasil), empregando como recurso principal um material didático chamado miniplanetário (MP). Utilizando como pressuposto teórico norteador dessas aulas as ideias de contextualização e dialogicidade de Paulo Freire, foi proposta aos estudantes a montagem e utilização desse recurso em uma sessão de planetário. Durante o projeto, enfatizaram-se assuntos como a trajetória aparente das estrelas para o céu de Brasília, a localização dos pontos cardeais a partir da constelação do Cruzeiro do Sul, as cores das estrelas e as estrelas vistas de uma determinada localidade. Apurou-se que os alunos apresentaram melhoria na compreensão desses assuntos, bem como demonstraram expressiva empolgação com essa metodologia desenvolvida.

  10. Excising das All: Evolving Maxwell waves beyond Scri

    NASA Technical Reports Server (NTRS)

    vanMeter, James R.; Fiske, David R.; Misner, Charles W.

    2006-01-01

    We study the numerical propagation of waves through future null infinity in a conformally compactified spacetime. We introduce an artificial cosmological constant, which allows us some control over the causal structure near null infinity. We exploit this freedom to ensure that all light cones are tilted outward in a region near null infinity, which allows us to impose excision-style boundary conditions in our finite difference code. In this preliminary study we consider electromagnetic waves propagating in a static, conformally compactified spacetime.

  11. Das Deutschlandspiegelvideo (The View-of-Germany-Videos).

    ERIC Educational Resources Information Center

    Pentecost, Gislind E.

    1993-01-01

    Describes View-of-Germany-Videos, published by the Goethe Institute. The videos are authentic, entertaining, and very versatile in usefulness. In addition they are short, thus easily incorporated into a lesson plan, and free of charge, making them accessible to any educational establishment. (AB)

  12. Erfolgsfaktoren von Lehrstellenmarketing in der dualen berufsbildung: das beispiel Schweiz

    NASA Astrophysics Data System (ADS)

    Sager, Fritz

    2006-09-01

    SUCCESS FACTORS OF APPRENTICESHIP MARKETING IN A SYSTEM OF DUAL VOCATIONAL TRAINING: THE CASE OF SWITZERLAND - The dual system of vocational training, utilizing both company training and vocational school, is generally acknowledged to be a successful model, but a decreasing number of trainee posts in Switzerland poses a crisis for the approach. One strategy for overcoming the problem involves offering incentives for companies to create new trainee posts. The present study explores the necessary conditions for successfully influencing the number of trainee posts through apprenticeship marketing. A comparision of qualitative case studies of six marketing projects demonstrates that while context, in the sense of basic structural conditions and political sensibility for the problematic, plays a role in the success of a project, what is central is above all the form of the trainee-post marketing project itself. This has to do with the behaviour of the actors involved as well as the choice of the mode of governance and project organization. The latter has to do with making available requisite technical and personal resources, coordination on the part of the project direction, and giving those responsible the necessary room to act in implementing the project.

  13. Demokratie lernen am gymnasium: das projekt "schule als staat"

    NASA Astrophysics Data System (ADS)

    Sajak, Clauß Peter

    2002-09-01

    (Learning Democracy in High School: the "School as State" Project) - The disquieting social developments in the German Federal Republic are leading to intense discussions about the possibilities of instilling values and democratic attitudes within the context of secondary education. The interdisciplinary educational project "School as State" has been running for some time in various schools in Baden-Württemberg. This article describes the goals and processes of this project and examines the didactic approaches from which it emerged.

  14. Der Forschungsflughafen und das Institut fuer Luft- und Raumfahrtsysteme

    DTIC Science & Technology

    2007-11-02

    Forschungsflughafen Aerodata Deutsches Zentrum für Luft- und Raumfahrt DLR VW Air Services TU Braunschweig Luftfahrt-Bundesamt LBA Deutscher Aeroclub... Aerodata - Weltmarktführer für Flight Inspection Systeme Flight Inspection - Flugvermessung

  15. Identifizierung der Eintragsquellen von Antibiotika in das Grundwasser viehstarker Regionen

    NASA Astrophysics Data System (ADS)

    Hannappel, Stephan; Köpp, Claudia; Zühlke, Sebastian; Balzer, Frederike; Schulz, Dietrich

    2016-11-01

    Only few sulfonamide antibiotics were detected in near-surface groundwater in areas with a high stocking rate in northwestern Germany. Intensive sampling with a high resolution in time and space was applied in order to illuminate the findings. As some pharmaceuticals can be of both human and animal origin, they may enter the environment via application of manure/digestate to arable land or via domestic waste water. In addition to existing monitoring wells, non-permanent wells were sampled to obtain information regarding pathways into the ground water. Interviews with farmers and chemical analyses show that application of manure leads to low concentrations (<100 ng/l) of Sulfadimidin and Sulfadiazin in most of the investigated samples. Sulfamethoxazol was found above 100 ng/l and likely originated from sewage of nearby small scale wastewater treatment plants. Sulfamethoxazole and its main metabolite could be detected within the plants; additionally, the sewage tracer acesulfam-K was detected in the groundwater.

  16. Das Deutschlandspiegelvideo (The View-of-Germany-Videos).

    ERIC Educational Resources Information Center

    Pentecost, Gislind E.

    1993-01-01

    Describes View-of-Germany-Videos, published by the Goethe Institute. The videos are authentic, entertaining, and very versatile in usefulness. In addition they are short, thus easily incorporated into a lesson plan, and free of charge, making them accessible to any educational establishment. (AB)

  17. Entwicklungsarbeit am Spurendetektor fur das CDF Experiment am Tevatron

    SciTech Connect

    Hartmann, Frank

    2000-02-01

    Silicon, the element, which revolutionized the development of electronics, is known as an important and multiusable material, dominating todays electronic technology. It's properties are well investigated and today well known. Silicon is used in solar cells, computers and telecommunications. Since the Sixties semiconductors have been used as particle detectors. Initially they were operated in fixed- target experiments as calorimeters and as detectors with a high precision track reconstruction. Since the Eighties they are widely used in collider experiments as silicon microstrip or silicon pixel detectors near the primary vertex. Silicon sensors have a very good intrinsic energy resolution: for every 3.6 eV released by a particle crossing the medium, one electron-hole pair is produced. Compared to 30 eV required to ionize a gas molecule in a gaseous detector, one gets 10 times the number of particles. The average energy loss and high ionized particle number with 390 e V / μm ~ 108 (electron - hole pairs)/ μm is effectively high due to the high density of silicon. These detectors allow a high precision reconstruction of tracks, primary and secondary vertices, which are especially important for b flavour tagging. The Tevatron and its detectors are being upgraded for the next data taking run starting in 2001 (RUN II). The Collider Detector at Fermilab (CDF) [2] for the upcoming Run II and its upgraded components are described in chapter 2. The main upgrade project is the design and construction of a completely new inner tracking system.

  18. Facetten der Reurbanisierung. Das Beispiel Mönchengladbach

    NASA Astrophysics Data System (ADS)

    Hamm, Rüdiger; Jäger, Angelika; Keggenhoff, Katja

    2017-06-01

    In the light of an increasing importance of the discussion on reurbanization, the article analyses the current socioeconomical and structural development of the city of Moenchengladbach. City development processes are marked by a high degree of dynamic individualization - an increasing number of cities have achieved a stage of reurbanization, whereas others have not completeley reached that stage of urban renewal. An analysis of Moenchengladbach indicates that quantative aspects of reurbanization are fulfilled, whereas qualitative reurbanisation processes as an increasing attractiveness, urban revaluation, and gentrification of innercity areas remain a future potential.

  19. Das andere Zuhause. Ortsbezüge hochqualifizierter Migranten

    NASA Astrophysics Data System (ADS)

    Plöger, Jörg; Günther, Florian

    2016-12-01

    Cities are increasingly addressing high-skilled migrants. Our contribution examines the factors that shape how this group relates to places and why cities provide different conditions for this. We draw on empirical data from an explorative case study with highly qualified migrants in the university city of Münster. First, we look at the place ties at the new place of residence and thereby focus on their local social networks and their sense of belonging. Second, we turn to the place-specific characteristics, in particular the role of "connections" and "urban opportunity structures". Based on our findings we discuss how urban policy-making may influence the place attachment of this desired group.

  20. Das Isotopenthermometer im ewigen Eis: Mechanismen globaler Klimaschwankungen

    NASA Astrophysics Data System (ADS)

    Stauffer, Bernhard

    Die Analysen von zwei Bohrkernen im grönländischen Eis haben unser Wissen über Klimaschwankungen und deren mögliche Ursachen stark erweitert. Die 18 O-Messreihe zeigt, dass der Übergang von der letzten Eiszeit zur Nacheiszeit in drastischen Sprüngen erfolgte und dass es auch während der Eiszeit schnelle, drastische Klimaänderungen, so genannte Dansgaard-Oeschger -Ereignisse gab. Basierend auf der heute gültigen Beziehung zwischen mittlerer Jahrestemperatur und 18 O-Wert nahm man an, dass der Temperaturanstieg zwischen Eiszeitmaximum und Nacheiszeit rund 12°C und zu Beginn eines Dansgaard-Oeschge-Ereignisses rund 8°C betrugen. Neue Kalibrationsmethoden haben gezeigt, dass die Temperatursprünge praktisch doppelt so groß waren, wie die mit der Dansgaard-Beziehung ermittelten. Erstaunlich sind vor allem die schnellen Temperaturanstiege. Ein Temperaturanstieg von mehr als 10°C e folgte oft in wenigen Jahrzehnten. Die Methanmessreihe ergab, dass die Dansgaard-Oeschger -Ereignisse kein auf Grönland beschränktes Phänomen sind. Es sind Klimaschwankungen von globaler Bedeutung. Die zeitliche Synchronisation von Messreihen auf Grönland und der Antarktis mithilfe von Methanvariationen ergab, dass einer abrupten Erwärmung in Grönland oft eine Erwärmung in der Antarktis vorausging. Von zwei Kernbohrungen im Rahmen des European Project for Ice Coring in Antarctica erwartet man vor allem neue Erkenntnisse über Klimawechselwirkungen zwischen den beiden Hemisphären und über die Ursachen der Variationen von Treibhausgaskonzentrationen parallel zu globalen Klimaschwankungen.

  1. Das modale Hilfsverb "will" (The Modal Auxiliary Verb "Will")

    ERIC Educational Resources Information Center

    Kunsmann, Peter W.

    1975-01-01

    That "will" and "shall" are modal, not temporal, verbs is shown by their syntactic similarity to the modals and by the fact that they follow the same transformational rules as the modals. This example demonstrates the usefulness of transformational grammar in explaining grammatical relationships to students. (Text is in…

  2. [Effect of training intensity on the fat oxidation rate].

    PubMed

    Ulloa, David; Feriche, Belén; Barboza, Paola; Padial, Paulino

    2014-01-01

    Introducción: El ejercicio físico es un importante modulador de la máxima tasa de oxidación de grasas (MFO). Sin embargo, en la relación MFO-ejercicio, las zonas de transición metabólica en la prescripción del ejercicio no son consideradas. Objetivo: Conocer el efecto del entrenamiento en diferentes zonas de transición metabólica sobre la cinética de la MFO y su localización (Fatmax) en jóvenes varones activos. Método: 97 varones fueron distribuidos en 4 grupos homogéneos, 3 experimentales y un grupo control (GC). Cada grupo experimental participó en 8 semanas de entrenamiento administrado de forma continua a intensidad de umbral aeróbico o VT1 (CCVT1), interválica en umbral anaeróbico o VT2 (ITVT2), y en potencia aeróbica máxima o VO2max (ITVO2max). Antes y después del tratamiento los sujetos fueron testados en sendas pruebas con control de gases espirados para determinar el VO2max, VT1 y VT2, y la MFO (calorimetría indirecta) y Fatmax. Resultados: Los resultados muestran un incremento (entre 16,49 y 18,51%; p.

  3. On the Formation of a Study Group to the Realization of Workshops for Teachers: Astronomy in Basic Education in Umuarama-Pr (Spanish Title: De la Formación de un Grupo de Estudios a la Realización de los Talleres Para los Profesores: la Astronomía en la Educación Básica en Umuarama-Pr ) Da Formação de um Grupo de Estudos À Realização de Oficinas Para Professores: a Astronomia na Educação Básica em Umuarama-Pr

    NASA Astrophysics Data System (ADS)

    Belusso, Diane; Akira Sakai, Otávio

    2013-12-01

    execução da pesquisa e das oficinas promoveu o contato direto do grupo de estudos com a comunidade; os resultados serviram de diagnóstico do ensino-aprendizagem de astronomia, na educação básica, em Umuarama-PR.

  4. Disciplines and Professors of Astronomy in Undergraduate Physics Teachers Formation Courses in Brazilian Universities. (Spanish Title: Disciplinas y Profesores de Astronomia en los Cursos de Licenciatura en Física en Las Universidades Brasileñas.) Disciplinas e Professores de Astronomia Nos Cursos de Licenciatura em Física das Universidades Brasileiras

    NASA Astrophysics Data System (ADS)

    Roberto, Artur Justiniano, Jr.; Reis, Thiago Henrique; dos Reis Germinaro, Daniel

    2014-12-01

    formación. Aparte de eso, los datos levantados en este trabajo apuntan para un número bajo de afiliados a la SAB (Sociedade Astronômica Brasileira) en los cursos investigados. Se verificó que tener astrónomos en una institución no implica tener una disciplina obligatoria de Astronomía en el curso de licenciatura en Física. Este artigo é o resultado de uma pesquisa sobre a formação básica em Astronomia nos cursos de Licenciatura em Física que fizeram o exame nacional ENADE 2011. O objetivo do trabalho foi identificar se há disciplinas de Astronomia nesses cursos, se ela é obrigatória ou optativa/eletiva, qual a sua carga horária e o período em que é oferecida. Pesquisou-se também a relação entre astrônomos, cursos de Licenciatura em Física e disciplinas de Astronomia. Para realizar essa pesquisa utilizamos os dados do ENADE 2011 e também do censo da Astronomia brasileira. Como resultado, se observa que em apenas 15% dos cursos existe uma disciplina obrigatória de Astronomia e que há uma grande probabilidade de que 85% dos professores de Física formados em 2011 não cursaram nenhuma disciplina de Astronomia durante a graduação. Além disso, os dados levantados nesse trabalho apontam um baixo número de filiados à SAB nos cursos pesquisados. Identifica-se que ter astrônomos na instituição não implica em disciplina obrigatória de Astronomia no curso de Licenciatura em Física.

  5. Memories of Astronomy Education in Brazil: Clippings from the Discourses of Interviewed Researchers on the Subject. (Spanish Title: Memorias de la Educación en Astronomía en Brasil: Recortes de los Discursos de Investigadores Entrevistados Acerca del Tema ) Memórias da Educação em Astronomia no Brasil: Recortes a Partir das Falas de Pesquisadores Entrevistados sobre o Tema

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Nardi, Roberto

    2014-12-01

    This paper presents a historical retrospective concerning data from a research in Astronomy Education in Brazil, after 1973. It was organized on the basis of the speech analysis of national researchers considered references in this field by their peers. Furthermore, it was elaborated on the basis of other studies from the areas of Science Education, Physics and Astronomy. This historical overview was developed in order to facilitate understanding of the contexts in which the interviewed researchers have developed professionally. Moreover, we attempted to recover the memory of the growing field of research in Astronomy Education in the country. We believe that the history presented can help those trying to understand the past in an attempt to resolve current and future demands. Se presenta en este artículo una retrospectiva histórica referente a datos provenientes de la investigación en enseñanza de la astronomía en el Brasil, después de 1973, organizada sobre la base del análisis de los discursos de los investigadores nacionales considerados referencias en este campo, y también en la lectura de las publicaciones en las áreas de Enseñanza de las Ciencias, Física y Astronomía. Este repaso histórico se desarrolló con el fin de facilitar la comprensión de los contextos en los que los investigadores entrevistados se han desarrollado profesionalmente. Por otra parte, se intentó recuperar la memoria del creciente campo de la investigación en Educación en Astronomía en el país. Creemos que el relato presentado puede contribuir a quien trata de comprender el pasado, en un intento de resolver las demandas actuales y futuras. Relata-se neste artigo uma retrospectiva histórica referente a dados provenientes de pesquisa em Educação em Astronomia no país, pós 1973, organizada com base na análise das falas de pesquisadores considerados referências nacionais nesse campo, como também na leitura de publicações das áreas de ensino de Ciências, F

  6. A confirmatory factor analysis of the "Autoconcepto Forma 5" questionnaire in young adults from Spain and Chile.

    PubMed

    García, José Fernando; Musitu, Gonzalo; Riquelme, Enrique; Riquelme, Paula

    2011-11-01

    The aim of this work is to examine the pentafactorial validity of the AF5 Self-Concept Questionnaire in Spanish and Chilean young adults. From the responses of a total of 4,383 young adults aged 17 to 22 years (1,918 Spanish, 44%, and 2,465 Chilean, 56%) it was analyzed the reliability of the instrument, the compared validity of the 5 oblique factor model proposed by the authors versus the unifactorial and the orthogonal alternative models, and was studied the invariance of one Chilean sample. The results of confirmatory factor analyses supported the authors' pentafactorial model. The multi-group factorial invariance showed that Chilean sample of the AF5 does not change neither the Spanish factor weights, nor the variances and covariances of the factors, or the error variances of items. Finally, the internal consistency of the five scales was good in the samples of both countries.

  7. Estudio de la influencia de la refrigeracion con aire de forma natural e inducida en el comportamiento de instalaciones fotovoltaicas

    NASA Astrophysics Data System (ADS)

    Mazon Hernandez, Rocio

    The aim is to analyse the negative influence of high panel temperatures on electrical production when they are placed on steel roofs of industrial buildings and greenhouse roofs. Different configurations have been tested in order to allow cooling of photovoltaic panels to decrease panel temperature and improve electrical performance. To research this problem two experimental facilities have been built. The first facility includes two panels fixed on a structure. A panel is integrated on a parallel steel plate which does not allow sufficient cooling. Between both surfaces, there is an open air channel in which an air flow is created by the chimney effect thus cooling the panel by natural convection or inducing air, using a fan, by forced convection. The other panel has not any plate underneath it and is used as a referent. The electrical behaviour of the integrated panel has been studied for different air gaps and induced velocities, being also compared with the reference panel. An experimental model was developed to establish correlations which allow determine the panel temperature depending on the influential variables on the cooling ability. This research also analyses the data of a working solar plant, with the same panel model, obtaining the correlations between electrical variables and panel temperature. A comparison with the electrical behaviour in the experimental facility and the solar plant is also presented. The second experimental facility is a replica of a photovoltaic greenhouse. It consists of four photovoltaic panels placed on the plastic roof, providing an open and divergent channel between both surfaces thus creating an air flow by natural convection. This research studies the effect of high temperatures within the greenhouse which is transferred by the roof and thus affects the electrical production. In addition, two air gaps were used and the effect of adding insulating material to the plastic roof was studied. The electrical variables of the panels are analysed to compare and select the best configuration. The presented research provides a deep knowledge of how they work as well as information and results for an improvement in future designs of building integrated photovoltaic systems. Este estudio se centra en analizar la influencia negativa de la temperatura en la produccion electrica de paneles fotovoltaicos al estar emplazados sobre cubierta de acero, como sucede en naves industriales y sobre un invernadero. Se estudian diferentes configuraciones que permitan refrigerar los paneles, reduciendo su temperatura y mejorar su rendimiento. Para abordar este problema, se han construido dos instalaciones experimentales, fieles a plantas solares en funcionamiento. Una instalacion engloba dos paneles fotovoltaicos sobre estructura fija al suelo. Uno de los paneles esta integrado sobre una superficie paralela y metalica. Entre ambas superficies existe un espacio que posibilita circular aire, permitiendo refrigerar el panel por conveccion natural, o conveccion forzada impulsando el aire con un ventilador. El otro panel, libre por su cara posterior y se ha considerado de referencia. Se ha estudiado el comportamiento del panel integrado sobre cubierta para diferentes secciones de aire y velocidades inducidas, comparandolo con el panel de referencia. Se ha desarrollado un modelo experimental que nos permite determinar la temperatura del panel en funcion de las variables que influyen en su refrigeracion. Adicionalmente, se han analizado los datos de una planta solar en funcionamiento, con paneles de igual caracteristicas, obteniendo correlaciones entre la temperatura del panel y las variables electricas y comparandolos con las obtenidas en la instalacion experimental. La segunda instalacion experimental reproduce parte de una instalacion solar sobre un invernadero, formada por cuatro paneles fotovoltaicos colocados sobre el plastico del invernadero, existiendo un canal divergente entre ambas superficies. Se estudia la influencia de las altas temperaturas en el interior del invernadero sobre la produccion electrica de los paneles, decido a la transferencia de calor del interior del invernadero. Ademas, se han ensayado dos separaciones diferentes y para cada una se ha comparado con la misma, utilizando un aislante sobre la cubierta. El estudio realizado sobre ambas instalaciones ha proporcionado un conocimiento profundo del funcionamiento de cada una de ellas, asi como informacion valida para una mejora de futuros disenos de instalaciones fotovoltaicas sobre cubiertas.

  8. Relevance and treatment of coccidiosis in domestic pigeons (Columba livia forma domestica) with particular emphasis on toltrazuril.

    PubMed

    Krautwald-Junghanns, Maria-Elisabeth; Zebisch, Ralph; Schmidt, Volker

    2009-03-01

    Coccidia are common pathogenic parasites in pigeons (Columba livia). Coccidiosis is most commonly seen in young pigeons and only rarely in adult birds. Infections in domestic pigeons are typically mixed and commonly include Eimeria columbarum and Eimeria labbeana. The reported prevalence of infection is 5.1%-71.9%, and worldwide mortality in juvenile pigeons varies from 5% to 70%, with most deaths occurring in the third and fourth month of life. This article summarizes the life cycle of E. columbarum and E. labbeana, the route of transmission, and the common clinical and pathologic signs of coccidiosis. Chemotherapeutic options discussed include amprolium, sulfonamides, clazuril, and toltrazuril. Reasons to use toltrazuril include the growing resistance against other drugs, such as sulfonamides and amprolium, the extended effectiveness compared with other substances, for example, clazuril, and the ability of pigeons to develop immunity during treatment.

  9. Thomas Kuhn is alive and well: the evolutionary relationships of simple life form--a paradigm under siege ?

    PubMed

    Lyons, Sherrie Lynne

    2002-01-01

    A Kuhnian framework is used to analyze the current controversy over whether two or three fundamental types of life forms exist. Until the 1980s, all life was classified into two primary forms: eukaryotes and prokaryotes. Using molecular sequencing data, Carl Woese suggested the archaebacteria constituted a third domain. In the mid-1990s, Radhey S. Gupta challenged the three-domain hypothesis. While this dispute may seem to be a purely technical debate over the analysis of protein and nucleic acid sequence data, the controversy encompasses broader issues such as the aims of classification and the role of microorganisms in the biosphere. At the heart of this dispute is what kinds of data are relevant to constructing an overall taxonomy. The prestige of molecular biology played a large role in why the three-domain hypothesis was accepted so readily, but supporters of the two-domain hypothesis argue that the fossil record, morphology, and cell physiology should all play a role in taxonomy. This case study provides a good example of a paradigm shift in the making, demonstrating that issues beyond the raw data will be significant factors in deciding whether the three-domain hypothesis will prevail or a new classificatory scheme will emerge.

  10. Infection of Brachypodium distachyon by formae speciales of Puccinia graminis: early infection events and host-pathogen incompatibility

    USDA-ARS?s Scientific Manuscript database

    Brachypodium distachyon is an emerging model to study fungal disease resistance in cereals and grasses. We characterized the stem rust-Brachypodium pathosystem to evaluate its potential for investigating molecular and genetic aspects of resistance to P. graminis, the pathogen that causes stem rust. ...

  11. Estudio general de la region del Lago Titicaca evaluando en forma preliminar un sistema de analisis interactivo de imagenes multiespectrales

    USGS Publications Warehouse

    Brockmann, C.E.; Carter, William D.

    1976-01-01

    ERTS-1 digital data in the form of computer compatible tapes provide the geoscientist with an unusual opportunity to test the maximum flexibility of the satellite system using interactive computers, such as the General Electric Image 100 System. Approximately 9 hours of computer and operator time were used to analyze the Lake Titicaca image, 1443-14073, acquired 9 October 1973. The total area of the lake and associate wetlands was calculated and found to be within 3 percent of previous measurements. The area was subdivided by reflectance characteristics employing cluster analysis of all 4 bands and later compared with density values of band 4. Reflectance variations may be attributed to surface roughness, water depth and bottom characteristics, turbidity, and floating matter. Wetland marsh vegetation, vegetation related to ground-water effluents, natural grasses, and farm crops were separated by cluster analysis. Sandstone, limestone, sand dunes, and several volcanic rock types were similarly separated and displayed by assigned colors and extended through the entire scene. Waste dumps of the Matilde Zinc Mine and smaller mine workings were tentatively identified by signature analysis. Histograms of reflectance values and map printouts were automatically obtained as a record of each of the principal themes. These themes were also stored on a work tape for later display and photographic record as well as to serve in training. The Image 100 System is rapid, extremely flexible and very useful to the investigator in identifying subtle features that may not be noticed by conventional image analysis. The entire scene, which covers 34,225 km2, was analyzed at a scale of 1:600,000, and portions at 1:98,000 and 1:25,000, during a 9-hour period at a rental cost of $250 per hour. Costs to the user can be reduced by restricting its uses to specific areas, objectives, and procedures, rather than undertaking a complete analysis of a total scene.

  12. Propriedades físicas de condensações densas no Escorpião

    NASA Astrophysics Data System (ADS)

    Vilas-Boas, J. W. S.; Barbosa, P. R., Jr.; Hickel, G. R.

    2003-08-01

    O conhecimento das propriedade físicas das condensações das nuvens escuras e sua relação com a dinâmica das núvens é um dos caminhos para o entendimento dos mecanismos de formação de estrelas de massas pequenas. Nesse trabalho, 8 condensações da nuvem escura do Escorpião foram observadas através de transições das moléculas de 13CO, C18O e NH3, utilizando-se os radiotelescopios de 15 m do SEST e 64 m de PARKES. Embora localizadas na superfície de uma bolha com velocidade de expansão entre 12 km/s e 15 km/s (Vilas-Boas et al), as linhas de monóxido de carbono apresentaram características típicas daquelas observadas em nuvens escuras. Em apenas uma condensação, contendo um objeto Pre-Sequência Principal (PMS), foi detectada emissão da molécula de amônia. A comparação direta entre as propriedades dessas condensações densas (núcleos) e aquelas identificadas na Musca, que se caracteriza por ser uma núvem de baixa atividade de formação estelar, mostra que elas têm propriedades idênticas e que as eficiências de formação estelar nos núcleos de ambas as nuvens são similares.

  13. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... scallop vessel issued an Occasional limited access permit when fishing under the Sea Scallop Area Access... Atlantic sea scallop limited access permit, the vessel owner signs out of the VMS program for a minimum..., or while the vessel was not at sea. (e) VMS notifications—(1) VMS installation notification. (i)...

  14. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... scallop vessel issued an Occasional limited access permit when fishing under the Sea Scallop Area Access... Atlantic sea scallop limited access permit, the vessel owner signs out of the VMS program for a minimum..., or while the vessel was not at sea. (e) VMS notifications—(1) VMS installation notification. (i)...

  15. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... scallop vessel issued an Occasional limited access permit when fishing under the Sea Scallop Area Access... Atlantic sea scallop limited access permit, the vessel owner signs out of the VMS program for a minimum..., or while the vessel was not at sea. (e) VMS notifications—(1) VMS installation notification. (i)...

  16. Kepler, Galilei, the telescope and the consequences. (German Title: Kepler, Galilei, das Fernrohr und die Folgen)

    NASA Astrophysics Data System (ADS)

    Gaulke, Karsten; Hamel, Jürgen

    The papers of this volume are dedicated to Johannes Kepler, the astronomy of his time, and the consequences of his researches. They deal with the reception on the Copernican system of the world at the court of landgrave William IV in Kassel and the use of astronomy at a princely court in the 16th century, exemplified by the Kassel residence. Two contributions discuss a text fragment in Kepler's Astronomia Nova and the dimensions of the geo- and heliocentric systems of the world in Kepler's Mysterium Cosmographicum. Other contributions deal with mathematical aspects un Kepler's exchange of letters, the biography of Kepler's discussion partner Ph. Feselius, as well as the early reception of the Tabulae Rudolphinae in the calendar literature, telescopes in Kepler's time, Chr. Scheiner's optical theory of the eye, and finally in the continuation of the heliocentric world system by Otto von Guericke's natural philosophy and science. In conclusion, the documents of the planned call of Kepler to Rostock university, as well as the first publication of a recently found, hitherto unknown letter by Kepler.

  17. Story II: Kommerzialisierung innovativer Technologien - das Beispiel der WoodWelding SA

    NASA Astrophysics Data System (ADS)

    Mayer, Jörg; Plasonig, Gerhard

    Technologische Innovation war und ist der prinzipielle Grund der Erhöhung der Wertschöpfung von Produkten, Produktionsprozessen und Dienstleistungen in zumindest den letzten 100 Jahren. Die BoneWelding® Technologie ist - wie viele andere Plattformtechnologien auch - im universitären Umfeld entstanden. Um den Prozess, den die Gründer des Unternehmens WoodWelding SA erfolgreich durchlaufen haben, besser zu verstehen, folgen ein paar grundlegenden Ausführungen, die zu erfolgreicher Technologieentwicklung, -transfer und Unternehmens-Start-up führten.

  18. Das Studium: Vom Start zum Ziel: Lei(d)tfaden für Studierende

    NASA Astrophysics Data System (ADS)

    Messing, Barbara

    Wer studieren will, hat viele Fragen und muss viele Entscheidungen treffen. Dieser Leitfaden hilft, eine Wahl zutreffen, sich an der Hochschule zurecht zu finden und Hürden rechtzeitig zu erkennen und zu bewältigen. Es geht um Fragen wie: Wer unterstützt mich finanziell? Studentenwohnheim oder WG? Was bringt eine Vorlesung? Wie komme ich an eine Abschlussarbeit - und wie schreibe ich sie? Weitere Themen sind: Struktur der Hochschule, Lebensabschnitt Studium, Motivation beim Lernen, Zeitmanagement im Studium, Recherchieren und Lesen, Verstehen und Entwickeln, Mathematik im Studium, Vorträge halten und Prüfungen bestehen.

  19. Das baden-württembergische Innovationssystem im Wandel:. Akteure vor neuen Herausforderungen

    NASA Astrophysics Data System (ADS)

    Stahlecker, Thomas; Zenker, Andrea

    2017-09-01

    Recently, new forms of innovation, new actors and actor constellations can be observed, especially in "mature" innovation systems like Baden-Wuerttemberg, that are flanked by new instruments of innovation support. Against the backdrop of an evolved innovation system heuristics, this paper outlines these new developments in Baden-Wuerttemberg. It uses examples to describe characteristic innovation actors, actors from the research landscape, education and the intermediary function of mediators, social actors as well as the aspect of innovation financing and to reveal current tendencies and trends. It becomes clear that the innovation system in Baden-Wuerttemberg has continuously evolved and become more differentiated. Its industries' research efforts and modernization activities as well as innovation-friendly policies contribute to the adaptability of the system and are major influencing factors for the ongoing success of the innovation system. This is supplemented by diverse innovations at the level of actors, institutions and measures. The question concerns the governance and capacity of this complex system given dynamic changing global circumstances.

  20. The Electron Microscope as an Aid in Colloid Research (Das Elektronenmikroskop als Hilfsmittel der Kolloidforschung),

    DTIC Science & Technology

    1978-03-09

    selected as an example. Because gold dispersions in borax glass are easier to prepare than those in silicate glass, we studied a borax pyrosol. The...mean gold particle size in borax melts prepared in various ways have been calculated by EHRINGHAUS and WINTGEN (7) from the gold concentration and the...number of particles estimated with the ultramicroscope. For example , in a light blue gold borax glass with 0.0127. gold content they find a mean part

  1. Kindern das Wort Geben ein interkulturell-kreativer Arbeitsansatz, aufgezeigt an der Arbeit mit tibetischen Migrantenkindern

    NASA Astrophysics Data System (ADS)

    Rabkin, Gabriele

    2001-03-01

    Promotion of creativity in the cause of peace and international understanding is a fundamental part of the UNESCO programme to build a culture of peace. A central aspect of this undertaking consists in encouraging children to express themselves freely on this subject in writing and art. An approach has been developed to stimulate children's creativity and to create a link between creative expression and education for intercultural understanding. This article is divided into two parts. The first explains the pedagogical and psychological concepts behind this approach. The second describes a project in which these concepts were applied. It focuses on a minority dispersed over many parts of the world, namely children of Tibetan families. The description is accompanied by commentaries of the Fourteenth Dalai Lama, arising from a personal audience granted to the author in 1999.

  2. Vehicle DAS Considerations for the Iron Gorget Threats: Analysis, Modelling and Comments to Operations Researchers

    DTIC Science & Technology

    2007-02-01

    10 Figure 8. RPG -7 radiance image ... imaging infrared, to detect and home in on targets. – BAT (Brilliant Anti-Tank) is an acoustic and infrared guided submunition that searches, tracks and...CO2 2.056×10−1 H2 2.076×10−1 14 DRDC Valcartier TM 2004–356 Figure 8. A radiance image from the RPG -7, the image is 0.4 m wide and 0.2 m high. DRDC

  3. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Point Gong Buoy “1AHP” 42°42.0′ 70°37.5′ 12. Connecting reference point 42°40′ 70°30′ 13. Whistle Buoy...′ 71°32.1′ 34. Shinnecock Inlet Lighted Whistle Buoy “SH” 40°49.0′ 72°28.6′ 35. Scotland Horn Buoy “S”, off Sandy Hook (NJ) 40°26.5′ 73°55.0′ 36. Barnegat Lighted Gong Buoy “2” 39°45.5′ 73°59.5′ 37. A...

  4. Das Gymnasium Zwischen Tradition und Modernen Bildungsanspruchen (The Gymnasium between Tradition and Modern Educational Requirements).

    ERIC Educational Resources Information Center

    Heller, Kurt A.

    2003-01-01

    Provides brief history of the German Gymnasium as a traditional European secondary school system with a preparatory function for higher education. Reviews the main goals of the gymnasium. Asks what role the gymnasium plays as a learning environment for gifted students. Discusses the politico-educational consequences and demands on the gymnasium.…

  5. Das Ende der Nacht [The End of the Night (2nd enlarged ed.)

    NASA Astrophysics Data System (ADS)

    Posch, Thomas; Hölker, Franz; Uhlmann, Thomas; Freyhoff, Anja

    2013-09-01

    We provide provide an overview of the history of lighting and of the problems arising from artificial lighting. The book covers the following topics: A brief history of light (ch. 1); night and light in cultural history (ch. 2); light pollution in central Europe (ch. 3); Moths and artificial lights (ch. 4); Artificial lighting and birds (ch. 5); Ocean turtles as victims of beach lighting (ch. 6); Moon light as a zeitgeber for the marine fauna (ch. 7); the influence of artificial light at night on freshwater ecology (ch. 8); artificial light and human health (ch. 9); the loss of the night in a 24 hours society (ch. 10).

  6. A Data Acquisition System (DAS) for marine and ecological research from aerospace technology

    NASA Technical Reports Server (NTRS)

    Johnson, R. A.

    1972-01-01

    The efforts of researchers at Mississippi State University to utilize space-age technology in the development of a self-contained, portable data acquisition system for use in marine and ecological research are presented. The compact, lightweight data acquisition system is capable of recording 14 variables in its present configuration and is suitable for use in either a boat, pickup truck, or light aircraft. This system will provide the acquisition of reliable data on the structure of the environment and the effect of man-made and natural activities on the observed phenomenon. Utilizing both self-contained analog recording and a telemetry transmitter for real-time digital readout and recording, the prototype system has undergone extensive testing.

  7. Consideracoes Extemporaneas acerca das Metodologias Qualitativas (Extemporaneous Considerations about Qualitative Methodology).

    ERIC Educational Resources Information Center

    Pucci, Bruno

    2000-01-01

    Considers the differences between quantitative and qualitative research. Cites some essays by Adorno when he was living in New York which led to the conclusion that empirical data has much to say and discusses the theoretical-methodological contributions in a recent master's thesis in education. (BT)

  8. Joint Confirmatory Factor Analyses of the DAS and WISC-R.

    ERIC Educational Resources Information Center

    Stone, Brian J.

    1992-01-01

    Investigated joint factor structure of Differential Abilities Scale and Wechsler Intelligence Scale for Children-Revised for 115 children. Compared theoretically supportable models (Spearman's General factor; Wechsler's Verbal, Performance, and Freedom from Distractibility factors; Elliott's verbal, nonverbal, spatial, and diagnostic perspective)…

  9. [Dementia in patients of Hospital das Clínicas da UNICAMP].

    PubMed

    Silva, David W; Damasceno, Benito P

    2002-12-01

    To report the relative frequencies of the causes of dementia in patients seen at UNICAMP Hospital. From 1989 to 1998, 261 dementia patients were admitted (89.7% studied retrospectively, and 10.3%, prospectively); mean age 63.5 years (+/-13.2), and education 3.6 years +/- 3.9; 25% illiterate). Diagnosis of dementia and its subtypes was based on DSM-IV criteria, CAMDEX, NINCDS-ADRDA, NINDS AIREN/ADDTC, Lund-Manchester, besides tap-test, including laboratory and neuroimaging examinations. Sixty five patients (24.9%) had vascular dementia, 62 ( 23.7%) Alzheimer's, 29 (11.1%) depressive pseudodementia, 28 (10.9%) normal pressure hydrocephalus, 14(5.4%) mixed, 12 (4.6%) post-traumatic, 9 (3.4%) frontotemporal and 38 (14.5%) had diverse or unknown causes. Dementia was minimal or mild in 123 (47.1%), moderate in 95 (36.4%), and severe in 43 (16.5%). Frequency of vascular dementia was 24.9%, Alzheimer's 23.7%, and normal pressure hydrocephalus 10.7%, in disagreement with that found in the neurological literature (20-30%, 50%, and 1-4%, respectively), probably because we are dealing with cases admitted to a tertiary university hospital. Epidemiological studies are needed to disclose the true proportion of these dementia syndromes in the population.

  10. Deutsch als Fremdsprachenphilologie: Das Heidelberger Modell (German as a Foreign Language Philology: The Heidelberg Model)

    ERIC Educational Resources Information Center

    Dietrich, Rainer; Heuer, Fritz

    1975-01-01

    German as a Foreign Language Philology is a new subject developed at the New Philology Faculty of the University of Heidelberg. Students whose native language is not German can earn a Master of Arts in this field. The study plan, educational goals, and the content and organization of the curriculum are described. (Text is in German.) (TL)

  11. Das Sprachlabor und der Audiovisuelle Unterricht (The Language Laboratory and Audiovisual Instruction).

    ERIC Educational Resources Information Center

    Freudenstein, Reinhold, Ed.

    Four articles, written in German, discuss such aspects of the language laboratory as: teaching pronunciation in the laboratory (Heinrich Schrand), the dummy-element in transformational grammar (Helmut Heuer), testing in the language laboratory (Kenneth S. Leigh), and language laboratory work in Finland (Roland Freihoff). Nine book reviews on…

  12. Das Werden des Kosmos. Von der Erfahrung der zeitlichen Dimension astronomischer Objekte im 18. Jahrhundert.

    NASA Astrophysics Data System (ADS)

    Krafft, F.

    This paper deals with two of the initial stages through which the dimension of time, in the sense of an irreversible development, found its way into astronomical-cosmological thinking. The one resulted from the first consequential application of Newtonian principles and laws to cosmic entities outside of our solar system found in the "General Natural History or Theory of the Heavens" by Immanuel Kant. The other initial stage is found in the classification of 'nebulae' by William Herschel who introduced the historical time factor as a principle of order in addition to the outward shape, which had become common for all the different elements in natural history during the second half of the 18th century.

  13. Renewing information infrastructure at Hospital das Clínicas.

    PubMed Central

    Moura, L.; do Amaral, M. B.; Lira, A.; Tachinardi, U.; Teixeira, A. C.; Yamamoto, J.

    1998-01-01

    In this paper we describe the process of renewing the Informatics infrastructure of Sao Paulo University Medical School Hospital, a very complex environment. Our proposal consists of a change in the paradigm of Informatics and the use of Information Technology in the hospital. That change aims at making information available to the hospital, its managers, health care workers and patients. The paradigm change is reflected in every aspect of the new infrastructure: human resources, methods, and organizational structure, as we intend to demonstrate in this paper. This process is expected to be concluded by the end of this year, yielding benefits regarding costs, efficiency, and better patient care. PMID:9929210

  14. Bring Back "Das Kapital" Punishment! Credit Crunch and the Fall of the "Knowledge Economy"

    ERIC Educational Resources Information Center

    Stronach, Ian; Clarke, John

    2010-01-01

    This article contrasts the collapse of the twin political certainties of the 20th century--"scientific socialism" (1989) and "scientific capitalism" (2008). Such a collapse restores Uncertainty to her throne, and brings back the need to radically rethink political possibilities for the future. (Contains 1 note.)

  15. 50 CFR 648.53 - Target total allowable catch, DAS allocations, and individual fishing quotas.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... a Confirmation of Permit History as described in § 648.4(a)(1)(i)(J) for the entire fishing year... confirmation of permit history shall not be issued more than 2 percent of the TAC allocated to the IFQ scallop... permit history, or issued or renewed a limited access scallop permit or confirmation of permit...

  16. Bring Back "Das Kapital" Punishment! Credit Crunch and the Fall of the "Knowledge Economy"

    ERIC Educational Resources Information Center

    Stronach, Ian; Clarke, John

    2010-01-01

    This article contrasts the collapse of the twin political certainties of the 20th century--"scientific socialism" (1989) and "scientific capitalism" (2008). Such a collapse restores Uncertainty to her throne, and brings back the need to radically rethink political possibilities for the future. (Contains 1 note.)

  17. Diskrepanzen und Kongruenzen: Das Dilemma des afrikanischen Kindes zwischen Familie und Schule

    NASA Astrophysics Data System (ADS)

    Bauer, Annemarie

    1986-03-01

    This article expounds the theory that the failure of school is due to the incompatibility of the educational goals of school and traditional upbringing in Africa. The thesis is put forward by adherents of the psychoanalytical model of child development and seeks to emphasize the discrepancies between the childhood where children are not frustrated and where their needs are cared for and the school education which represses the drives and its socialization of children. Finding a number of anthropological studies are discussed and reinterpretations of the ethno-psychoanalytical materials attempted. Neither the evaluation of childhood in Africa nor the theory that with school come wholly new expectations of behaviour (e.g., a performance requirement) can no longer be maintained. In conclusion, other explanations for the difficulties encountered by school in Africa are offered.

  18. Das Schwimmen der Talitridae (Crustacea, Amphipoda): Funktionsmorphologie, Phänomenologie und Energetik

    NASA Astrophysics Data System (ADS)

    Vogel, Friedhelm

    1985-09-01

    The Talitridae, well-known for their jumping behaviour, swim with help of the tail-flip. This movement of the abdomen is also known from other amphipods like the Gammaridae which are normally not able to move by jerks outside the water. The suspected homology between the tail-flip when swimming and the jerky movement of the abdomen when jumping gave rise to this investigation, mainly based on high frequency film recordings, on the swimming of Hyale nilssonii, Orchestia cavimana, and Talitrus saltator (family Talitridae) as well as three related species of the families Gammaridae and Corophiidae. Comparative morphometrical and SEM-studies on the habitus of the species and the build of the involved limbs reveal the rather uniform construction of the Gammaridea; functional adaptation to the environment and to the way of living become apparent in minor alterations. The joints of the pleopods and uropods show a clear structural adaptation to the mechanical strain during swimming. The pleopods are moved metachronally in all examined species; angular velocity and rate of beating indicate the efficiency of the swimming movement. In the Talitridae, the metachronal beat of the pleopods is nearly always coupled with the tail-flip while in the Gammaridae and Corophiidae the tail-flip, in addition to the beat of the pleopods, is mostly used for a start from the subsoil or for a change in swimming direction. H. nilssonii, Gammarus locusta, and Corophium volutator, all inhabitants of the tidal zone in the North Sea shallows, turned out to be the “best” swimmers while the (semi-) terrestrially living species, O. cavimana and T. saltator, proved to be rather “poor” swimmers. This clearly indicates the ecological significance of swimming for the different species. Furthermore, the tailflip is found to be of rather subordinate importance. It contributes to a higher velocity if used moderately but is rather obstructive if a large angle is covered while extending and flexing the abdomen. The efficiency of swimming is inversely proportional to the efficiency of jumping in the three talitridean species. Thus, better adaptation to terrestrial life is accompanied by loss of swimming efficiency. Examined under the aspect of locomotional homology, it is concluded that the tail-flip used while swimming is homologous to the jerky movement of the abdomen used for jumping. The comparison of the swimming performance of the examined species with other crustaceans and some fishes illustrates the over-all good results of the Gammaridea.

  19. Das Bild der Aufklarungspadagogik im Spiegel Deutschsprachiger Padagogischer Lexika Des 19. und 20. Jahrhunderts.

    ERIC Educational Resources Information Center

    Luth, Christoph

    1990-01-01

    Examines the educational lexicons of the nineteenth and twentieth centuries in order to investigate the influence of educational theories of the Enlightenment on Germany. Expounds on the educational theories of the Enlightenment. (RW)

  20. Das Smart Meter Gateway - Der kritische Erfolgsfaktor für die Digitalisierung der Energiewende

    NASA Astrophysics Data System (ADS)

    Abs, Paul-Vincent

    Der kritische Erfolgsfaktor der Digitalisierung in der Energiewirtschaft liegt im bevorstehenden hohen Investitionsvolumen und der Beherrschung der neuen Technik. Ein Weg zur Kostenminimierung liegt im Zusammenschluss der einzelnen Akteure, um gemeinsame Skalenvorteile zu heben. Auch bieten neue Geschäftsmodelle die Möglichkeit, zusätzliche Erlöse zu generieren.

  1. Ein Mensch ist ein Tier, das Schuhe tragt: Communication not Manipulation

    ERIC Educational Resources Information Center

    Sanders, Ruth H.

    1978-01-01

    A technique is described for eliciting true communication in the elementary German classroom which is also applicable to more advanced study. Students define simple words in German and are encouraged to help one another build a cumulative definition. The instructor reinforces the concept of language as a social activity. (SW)

  2. Consideracoes Extemporaneas acerca das Metodologias Qualitativas (Extemporaneous Considerations about Qualitative Methodology).

    ERIC Educational Resources Information Center

    Pucci, Bruno

    2000-01-01

    Considers the differences between quantitative and qualitative research. Cites some essays by Adorno when he was living in New York which led to the conclusion that empirical data has much to say and discusses the theoretical-methodological contributions in a recent master's thesis in education. (BT)

  3. ModSAF-Based Development of DAS for Light Armoured Vehicles

    DTIC Science & Technology

    2002-08-01

    Target Modeling and Validation Conference [13th] Held in Houghton, MI on 5-8 August 2002 To order the complete compilation report, use: ADA459530 The...produce accurate effects of attenuation over distance, scattering by smoke and dust and insolation. Spectral effects in the atmosphere, such Ground Target ... targeting information supplied by the UAV. Active armour is used to counter kinetic energy threats more effectively. The Radar system mentioned aboveis an

  4. A Integracao de Ensino das Ciencias da Saude (An Integrated Medical Education Program [in Brazil]).

    ERIC Educational Resources Information Center

    Pourchet-Campos, M. A.; Guimaraes Junior, Paulino

    At the Sixth Annual Reunion of the Brazilian Association of Medical Schools (VI Reuniao Anual da Associacao Brasileira de Escolas Medicas) leaders in the Brazilian medical profession proposed an integrated educational program for training students in the fields of medicine and public health. Under Brazil's present system of education, all…

  5. Kepler, Galilei, the telescope and the consequences. (German Title: Kepler, Galilei, das Fernrohr und die Folgen)

    NASA Astrophysics Data System (ADS)

    Hamel, Jürgen

    In the beginning Copernicus' system of the world did not have empirical confirmation. In this situation, Kepler's research, as well as the astronomical observations with the telescope, invented in 1608, played a decisive role. Under the assumption of the central position of the Sun, Kepler discovered the elliptical orbital motion of the planets as a base of the computation of noticeably improved ephemerides. The first telescopic observations - Jupiter's moons, phases of Venus, sunspots, surface features of the moon -, gave important arguments for Copernicus' system. Galilei was one of the first who used the telescope for astronomical research.

  6. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... trip via VMS. (9) Vessels issued a Tier 1, Tier 2, or Tier 3 limited access Atlantic mackerel permit... mackerel VMS notification requirements. (1) A vessel issued a limited access Atlantic mackerel permit intending to declare into the mackerel fishery must notify NMFS by declaring a mackerel trip prior...

  7. The Shadow of a Gnomon Along a Year: Routine Observations and Teaching of Apparent Motion of the Sun and the Four Seasons. (Spanish Title: La Sombra de un Gnomon lo Largo de un Año: Observaciones de Rutina y la Enseñanza del Movimiento Aparente del Sol y Las Cuatro Estaciones.) A Sombra de um Gnômon ao Longo de um Ano: Observações Rotineiras e o Ensino do Movimento Aparente do Sol E das Quatro Estações

    NASA Astrophysics Data System (ADS)

    Trogello, Anderson Giovani; Danhoni Neves, Marcos Cesar; de Carvalho Rutz da Silva, Sani

    2013-12-01

    , al solsticio de junio, al equinoccio de septiembre y al solsticio de diciembre. Además, se dictaron clases teóricas en la sala de aula. Estos métodos buscaron construir conceptos en torno al movimiento aparente del Sol y la sucesión de las estaciones. Teniendo en cuenta los resultados de las actividades se aplicó una evaluación cuyos datos demuestran la existencia de un aprendizaje deseado por los estudiantes en cuanto a: el reconocimiento de los puntos cardinales, la descripción del movimiento solar aparente y la aparición de las estaciones y su alternancia a partir de observaciones astronómicas visuales sin instrumentos. Muitas concepções alternativas são reconhecidas entre os diversos grupos de estudantes, em especial nos da educação básica. Dentre elas, o movimento aparente do Sol, por mais quotidiano que seja, proporciona variadas interpretações. Deste modo, observar e registrar o movimento dos astros na abóboda celeste é uma tarefa necessária ao ensino de Astronomia. O trabalho que ora se apresenta propõe a apresentação dos resultados da observação do movimento aparente do Sol por intermédio da marcação da sombra de um gnômon vertical por alunos de uma turma do sexto ano do ensino fundamental de uma escola do campo do Paraná. O projeto em si ocorreu em quatro etapas, em datas próximas do equinócio de março, do solstício de junho, do equinócio de setembro e do solstício de dezembro. Além disso, foram desenvolvidas aulas teóricas em sala de aula. Tais métodos buscaram construir conceitos em torno da movimentação aparente do Sol e da alternância das estações do ano. Diante dos resultados provenientes das atividades desenvolvidas foi aplicada uma avaliação e os dados demonstraram um aprendizado desejado dos alunos quanto: ao reconhecimento dos pontos cardeais; à descrição do movimento solar aparente e a ocorrência das estações do ano e sua alternância a partir de observações astronômicas a olho nu.

  8. Form--a matter of generation: the relation of generation, form, and function in the epigenetic theory of Caspar F. Wolff.

    PubMed

    Witt, Elke

    2008-12-01

    The question, how organisms obtain their specific complex and functional forms, was widely discussed during the eighteenth century. The theory of preformation, which was the dominant theory of generation, was challenged by different alternative epigenetic theories. By the end of the century it was the vitalist approach most famously advocated by Johann Friedrich Blumenbach that prevailed. Yet the alternative theory of generation brought forward by Caspar Friedrich Wolff was an important contribution to the treatment of this question. He turned his attention from the properties of matter and the forces acting on it towards the level of the processes of generation in order to explain the constitution of organismic forms. By regarding organic structures and forms to be the result of the lawfulness of ongoing processes, he opened up the possibility of a functional but non-teleological explanation of generation, and thereby provided an important complement to materialist and vitalist approaches.

  9. Forma y acción de la liberación de energía en la atmósfera solar

    NASA Astrophysics Data System (ADS)

    Mandrini, C. H.

    2016-08-01

    We briefly describe the lines of work developed over more than twenty years and their relevant results. Our scope is essentially that of active events that occur in the solar atmosphere covering wide temporal and spatial scales and energy range. We present results derived from the comparative analysis of active events and their interplanetary counterparts, as well as of aspects related to the quiet solar atmosphere, such as the heating of the corona and the origin of the slow solar wind.

  10. "O Ensaio como Forma" ou Um Ensaio acerca da Teoria Critica da Sociedade ("The Essay as Form" or An Essay about the Critical Theory of Society).

    ERIC Educational Resources Information Center

    Giordano, Rosely

    2000-01-01

    Illuminates the critical theory project, with themes permeating the theoretical constructions of Frankfurt (Germany). Debates the predominance of positivism in the production of knowledge. Speculates that "the essay as form" constitutes itself as a representation of the concept of the Enlightenment. Concludes with a dialogue between…

  11. Efecto del tamaño finito de la abertura del sistema optico que forma la imagen en la prueba de la navaja de fase.

    NASA Astrophysics Data System (ADS)

    Berriel-Valdos, L. R.

    The spatial filtering formalism is applied to optical testing techniques. As example the irradiance distribution of a diffraction limited system is calculated and focal errors and spherical and coma aberrations are discussed.

  12. Formas De Produccion Agricola E Intervenciones Educativas En A. Latina Y El Caribe. [Methods of Agricultural Production and Educational Intervention in Latin America and in the Caribbean].

    ERIC Educational Resources Information Center

    Mohor, S.

    This paper, one of a series of Unesco technical reports, discusses agricultural production in Latin America and the Caribbean and examines the role played by education in the region. Written in Spanish, the paper consists of four parts. Part I deals with the different types of agricultural production and examines the historic origins and…

  13. Identification of genes in Puccinia striiformis and use of gene-specific PCR primers to differentiate rust species, formae speciales, and isolates

    USDA-ARS?s Scientific Manuscript database

    Stripe rust, caused by Puccinia striiformis (P. s.), is an important disease on wheat, barley, and grasses. To study functional genomics, we have constructed a full-length cDNA library from urediniospores of P. s. f. sp. tritici. Of 196 sequenced cDNA clones, 37.8% had significant homology to the s...

  14. Early experience and domestication affect auditory discrimination learning, open field behaviour and brain size in wild Mongolian gerbils and domesticated laboratory gerbils (Meriones unguiculatus forma domestica).

    PubMed

    Stuermer, Ingo W; Wetzel, Wolfram

    2006-10-02

    The influence of early experience and strain differences on auditory discrimination learning, open field behaviour and brain size was investigated in wild-type Mongolian gerbils (strain Ugoe:MU95) raised in the wild (wild F-0) or in the laboratory (wild F-1) and in domesticated Laboratory Gerbils (LAB). Adult males were conditioned for 10 days in a shuttle box go/no-go paradigm to discriminate two frequency-modulated tones. Significant learning was established within 5 days in wild F-0 and within 3 days in wild F-1 and LAB. Spontaneous jumps in the shuttle box (inter-trial crossings) were frequently seen in wild F-0 and F-1, but rarely in LAB. All groups exhibited nearly the same ability to remember after 2 weeks without training. In the open field test applied on 5 consecutive days, no differences in locomotion patterns and inner field preferences were found. Rearing frequency decreased over 5 days in wild gerbils. Running distances (4-6m/min) were similar in wild F-0 and LAB, but higher in wild F-1. The ratio of brain size to body weight did not differ between wild F-0 and F-1, but was 17.1% lower in LAB. Correspondingly high brain weights in wild F-1 and F-0 support our domestication hypothesis and negate any serious effect of early experience or captivity on brain size in Mongolian gerbils. In contrast, wild F-1 raised in the laboratory show a rapid improvement in learning performance, indicating that early experience rather that genetic differences between strains affect shuttle box discrimination learning in gerbils.

  15. Fusarium oxysporum f. sp. palmarum, a Novel Forma Specialis Causing a Lethal Disease of Syagrus romanzoffiana and Washingtonia robusta in Florida

    USDA-ARS?s Scientific Manuscript database

    A new disease of Syagrus romanzoffiana (queen palm) and Washingtonia robusta (Mexican fan palm) has spread across the southern half of Florida during the past 5 years. The initial foliar symptom is a one-sided chlorosis or necrosis of older leaf blades, with a distinct reddish-brown stripe along th...

  16. Formas de Ampliar os Recursos Internacionales Para la Educacion en la America Latina (Recommendations for Extending International Assistance for Education in Latin America).

    ERIC Educational Resources Information Center

    Correa, Arlindo Lopes

    This report sets forth the commitment toward improving the over-all quality of education in Latin America as first announced at the Punta del Este Conference in 1967. Recognizing that education is a universal right and its implementation must not depend on socio-economic affluence or political motives of any region, members of the Organization of…

  17. Epidemiological multicentre study on the education provided to patients with type 2 diabetes mellitus in the Spanish Health Care System. The Forma2 study.

    PubMed

    García-Donaire, J A; Franch-Nadal, J; Rodríguez-Fortúnez, P; Labrador-Barba, E; Orera-Peña, M L; Rodríguez de Miguel, M

    2017-05-13

    The purpose of the present study was to characterize the education that patients with type 2 diabetes mellitus receive, and to identify differences as regards the presence of insulin therapy or not. This crossover, multicentre and descriptive study involved 1066 Spanish physicians who completed a questionnaire on Internet. The physicians that responded had a mean of 26.0 years of experience in healthcare, and mainly worked in a walk-in clinic in an urban area. Physicians rated the level of patient knowledge about their disease on a 5.0 point-scale. Fifty percent of them indicated that they spent between 15 and 30min in educating patients at the time of diagnosis. Previous control with HbA1c>9%, presence of microvascular complications, and a low socio-cultural level, were factors associated with spending more time in education. This is the first study designed to evaluate the education provided to patients with type 2 diabetes mellitus from Spain. The time spent and the individualization of the education are important factors associated with better long-term control of the disease, and thus with the effectiveness of the clinical management. Copyright © 2017 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  18. Formas De Produccion Agricola E Intervenciones Educativas En A. Latina Y El Caribe. [Methods of Agricultural Production and Educational Intervention in Latin America and in the Caribbean].

    ERIC Educational Resources Information Center

    Mohor, S.

    This paper, one of a series of Unesco technical reports, discusses agricultural production in Latin America and the Caribbean and examines the role played by education in the region. Written in Spanish, the paper consists of four parts. Part I deals with the different types of agricultural production and examines the historic origins and…

  19. "O Ensaio como Forma" ou Um Ensaio acerca da Teoria Critica da Sociedade ("The Essay as Form" or An Essay about the Critical Theory of Society).

    ERIC Educational Resources Information Center

    Giordano, Rosely

    2000-01-01

    Illuminates the critical theory project, with themes permeating the theoretical constructions of Frankfurt (Germany). Debates the predominance of positivism in the production of knowledge. Speculates that "the essay as form" constitutes itself as a representation of the concept of the Enlightenment. Concludes with a dialogue between…

  20. Comparative genomics and prediction of conditionally dispensable sequences in legume-infecting Fusarium oxysporum formae speciales facilitates identification of candidate effectors

    USDA-ARS?s Scientific Manuscript database

    Focusing on the identification of pathogenicity gene content, we leveraged the reference genomes of Fusarium pathogens F. oxysporum f. sp. lycopersici (tomato-infecting) and F. solani (pea-infecting) and their well-characterised core and dispensable chromosomes to predict genomic organisation in the...

  1. Understanding the curriculum the light of training guiding health in Brazil.

    PubMed

    Moraes, Bibiana Arantes; Costa, Nilce Maria da Silva

    2016-06-01

    To analyze Pedagogical Projects Courses (PPCs) from the healthcare field in light of the National Curriculum Standards (NCS) policies on healthcare training. Exploratory descriptive study of qualitative approach, in which were carried out analyzes of PPPs of Nursing, Pharmacy, Medicine, Nutrition and Dentistry of a federal university in the Midwest region of Brazil. As technical analysis of documentary sources, adopted the content analysis in the thematic mode. The analysis of PPC showed the general aspects of PPC as the course features the historical percursso and construction, professional skills and competences required for professional performance and the guiding principles of formation characterized by technical, professional practice, articulation theory/ practice, interdisciplinarity and ethical / social training. PPC presented is consistent with the proposals set out in DCN and carry training policies in health in Brazil, providing adequate training for health professionals, the demands of the population and the National Health System. Analisar os Projetos Pedagógicos de Cursos (PPC) da área da saúde à luz das Diretrizes Curriculares Nacionais (DCN) e das políticas indutoras de formação em saúde do Brasil. Pesquisa descritiva exploratória de abordagem qualitativa, na qual foram realizadas análises dos PPC dos cursos de Enfermagem, Farmácia, Medicina, Nutrição e Odontologia de uma instituição federal de ensino superior da região Centro-Oeste do Brasil. Como técnica de análises das fontes documentais, adotou-se a análise de conteúdo, na modalidade temática. As análises dos PPC evidenciaram os aspectos gerais dos PPC como as características do curso, o percursso histórico e sua construção, habilidades e competências profissionais requeridas para o desempenho profissional e os princípios norteadores da formação caracterizados pela técnica, prática profissional, articulação teoria/prática, interdisciplinaridade e formação

  2. [Assessing food acceptance in scholar children; qualitative visual record versus food waste analysis].

    PubMed

    Rodriguez Tadeo, Alejandra; Patiño Villena, Begoña; Periago Castón, María Jesús; Ros Berruezo, Gaspar; González Martínez-Lacuesta, Eduardo

    2014-05-01

    Introducción: Los comedores escolares cuentan con normativa de gestión y supervisión de menús, sin embargo no se ha valorado si son consumidos en su totalidad. Objetivo: Valorar la aceptación de alimentos mediante pesado de restos y validación de una metodología visual para su estimación en comedores escolares de Murcia. Metodología: Participaron escolares de segundo y tercer ciclo de educación primaria, de 8-12 años. La estimación de restos se realizó mediante pesado de alimentos de 765 bandejas. La valoración visual (300 bandejas) se realizó con escala categórica: 1 = 0-25%; 2 = 26-50%; 3 = 51- 75% y 4 = 76-100%, por dos dietistas y se valoró la fiabilidad con respecto al pesado de alimentos. La concordancia entre ambos métodos fue evaluada en dos muestras estratificadas por la presencia/ausencia de cocina en la escuela. Resultados: Los primeros platos con más restos fueron pasta, arroz y purés de verduras siendo mayor en aquellos colegios sin cocina en el centro (p < 0,05). También los segundos platos a base de legumbres, ave y pescado y ensaladas de guarnición. Las frutas y el total de restos son superiores en colegios sin cocina (p < 0,05). La concordancia entre evaluadoras fue alta en platos a base de carnes y en ensaladas, y considerable en legumbres, precocinados, tortilla de huevo, pasta, pescado y arroz. Conclusiones: Los restos son elevados y existieron diferencias en la aceptación de ciertos alimentos acorde al tipo de menú ofertado. La escala visual es una herramienta confiable para medir la aceptación de forma indirecta, pero necesita capacitación y entrenamiento del personal implicado.

  3. Rapid Diagnosis of Arbovirus and Arenavirus Infections by Immunofluorescence.

    DTIC Science & Technology

    1981-01-01

    and Barrera Oro, J.G. 1975. Serologia do a fiebre hemorragica Argentina. II. Comparacion de Is prueba indirecta de anticuerpos fluorescentes con Is... prueba de fijacion de complemento. Acts - - lioquimica Clinica Latinoamericana, 9: 141-146. Hotchin, J., and Kinch, W. 1975. Microplaque reduction: New

  4. Das Problem der Ubersetzbarkeit von Phraseologismen am Beispiel von Isabel Allendes Roman "Das Geisterhaus" (The Problem of the Translatability of Idioms using the Example of Isabel Allende's novel "The House of the Spirits").

    ERIC Educational Resources Information Center

    Cox, Luz

    1996-01-01

    Using the translation of Isabel Allende's novel "The House of the Spirits," this essay demonstrates that the mastery of a foreign language does not guarantee a translation true to the original. The Spanish of the Latin American countries exhibits numerous differences and does not always share a uniform vocabulary. Concrete measures are…

  5. Das Problem der Ubersetzbarkeit von Phraseologismen am Beispiel von Isabel Allendes Roman "Das Geisterhaus" (The Problem of the Translatability of Idioms using the Example of Isabel Allende's novel "The House of the Spirits").

    ERIC Educational Resources Information Center

    Cox, Luz

    1996-01-01

    Using the translation of Isabel Allende's novel "The House of the Spirits," this essay demonstrates that the mastery of a foreign language does not guarantee a translation true to the original. The Spanish of the Latin American countries exhibits numerous differences and does not always share a uniform vocabulary. Concrete measures are…

  6. População estelar jovem em galáxias irregulares próximas

    NASA Astrophysics Data System (ADS)

    Guimarães, T. A.; Telles, E.

    2003-08-01

    A análise do conteúdo estelar de galáxias próximas através da fotometria das suas estrelas resolvidas nos fornece informações importantes sobre a história de formação estelar e os processos de formação estelar em galáxias, que estão diretamente ligados ao estudo de evolução de galáxias. Quando nenhuma estrela puder ser resolvida o método mais poderoso consiste na análise do conteúdo estelar integrado das galáxias através das suas cores integradas em conjunto com informação espectroscópica que combinados com modelos de síntese evolutiva podem restringir simultaneamente a função de massa inicial (IMF) e a taxa de formação estelar (SFR). Nesse contexto, galáxias do tipo tardio, em particular, irregulares, são relevantes por várias razões: elas são objetos relativamente simples, com alta atividade de formação estelar e são objetos relativamente jovens (geralmente apresentam baixas abundâncias de elementos pesados e grande quantidade de gás). Apresentamos uma análise fotométrica de uma amostra de 7 galáxias do tipo tardio do universo local (NGC 2366, NGC 4395, NGC 4656, NGC 4214, NGC 4236, HOII, IC2574) que foram observadas com uma boa resolução espacial nas bandas B, V e R no telescópio Isaac Newton de 2.5m de Roque de los Muchachos nas Ilhas Canárias, Espanha. A distribuição espacial da população estelar jovem dessas galáxias é discutida sobre os pontos de vista dos íindices de cor integrados e dos seus diagramas cor magnitude, que comparados com isócronas teóricas, nos fornecem informações sobre os eventos de formação estelar, como por exemplo, indicações sobre a idade dos mesmos. As principais conclusões do trabalho podem ser resumidas em: (i) As galáxias irregulares possuem formação estelar recente (FE) espalhada ocorrendo nos últimos 50 Manos; (ii) A formação estelar em galáxias irregulares não é auto-propagante em escalas globais ( > 100 pc) ; (iii) A FE pode ser auto-regulável em escalas

  7. Neues "Francais fondamental?" Das Europa-Projekt "Un niveau seuil." (A New "Francais fondamental?" The European Project "A Threshold Level").

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The project "Threshold Level," initiated by the Council of Europe in 1976, is compared with "Francais fondamental," comparing their aims and their differences. Offered as an interim statement, the article leaves open the question of whether Francais fondamental should be replaced by the the Threshold Level. (IFS/WGA)

  8. Die physikalischen Umweltwissenschaften und das Militär Zur Erforschung Grönlands im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Heymann, Matthias

    Die modernen Umweltwissenschaften stehen heute im Mittelpunkt von Forschungsförderung und öffentlicher Aufmerksamkeit. Im Zuge des seit den 1970er Jahren erwachten Interesses am globalen Wandel der Umwelt und den damit verknüpften Problemen, ist ihre Bedeutung rasch gestiegen. Viele Wurzeln der modernen Umweltwissenschaften liegen jedoch im Kalten Krieg.

  9. Dermatomyositis: analysis of 109 patients surveyed at the Hospital das Clínicas (HCFMUSP), São Paulo, Brazil*

    PubMed Central

    Ortigosa, Luciena Cegatto Martins; dos Reis, Vitor Manuel Silva

    2014-01-01

    BACKGROUND Dermatomyositis affects striated muscles, skin and other organs. OBJECTIVE To characterize the disease from January 1992 to December 2002, assessing its classification, cutaneous and systemic manifestations, and also laboratory results, therapeutic and prognostic findings compared to those in the literature. METHODS Data were obtained from medical records of 109 patients who were classified into five groups: 23 juvenile dermatomyositis; 59 primary idiopathic dermatomyositis; 6 amyopathic dermatomyositis; 7 dermatomyositis associated with neoplasms and 14 dermatomyositis associated with other connective tissue diseases. RESULTS Sixty patients were classified as "definite" diagnosis; 33 as "possible"; four as "probable" and 12 and as amyopathic. The average age at diagnosis was 36 years. Cutaneous manifestations occurred in all patients; the most frequent symptom was loss of proximal muscle strength; the most common pulmonary disorder was interstitial lung disease, and gastritis was the most prevalent digestive manifestation. Tumors were documented in 6.42% of cases. Lactate dehydrogenase was the muscle enzyme most frequently elevated in the majority of cases. Skin biopsies were performed in 68 patients; muscle biopsies in 53; and electroneuromyographies in 58 patients. The most commonly used treatment was corticotherapy and the mortality rate was 14.7%. CONCLUSION in this sample, the disease appeared in younger individuals, was more frequent in women and the association with cancer was small. PMID:25184910

  10. Dermatomyositis: analysis of 109 patients surveyed at the Hospital das Clínicas (HCFMUSP), São Paulo, Brazil.

    PubMed

    Ortigosa, Luciena Cegatto Martins; Reis, Vitor Manuel Silva dos

    2014-01-01

    Dermatomyositis affects striated muscles, skin and other organs. To characterize the disease from January 1992 to December 2002, assessing its classification, cutaneous and systemic manifestations, and also laboratory results, therapeutic and prognostic findings compared to those in the literature. Data were obtained from medical records of 109 patients who were classified into five groups: 23 juvenile dermatomyositis; 59 primary idiopathic dermatomyositis; 6 amyopathic dermatomyositis; 7 dermatomyositis associated with neoplasms and 14 dermatomyositis associated with other connective tissue diseases. Sixty patients were classified as "definite" diagnosis; 33 as "possible"; four as "probable" and 12 and as amyopathic. The average age at diagnosis was 36 years. Cutaneous manifestations occurred in all patients; the most frequent symptom was loss of proximal muscle strength; the most common pulmonary disorder was interstitial lung disease, and gastritis was the most prevalent digestive manifestation. Tumors were documented in 6.42% of cases. Lactate dehydrogenase was the muscle enzyme most frequently elevated in the majority of cases. Skin biopsies were performed in 68 patients; muscle biopsies in 53; and electroneuromyographies in 58 patients. The most commonly used treatment was corticotherapy and the mortality rate was 14.7%. in this sample, the disease appeared in younger individuals, was more frequent in women and the association with cancer was small.

  11. Neues "Francais fondamental?" Das Europa-Projekt "Un niveau seuil." (A New "Francais fondamental?" The European Project "A Threshold Level").

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The project "Threshold Level," initiated by the Council of Europe in 1976, is compared with "Francais fondamental," comparing their aims and their differences. Offered as an interim statement, the article leaves open the question of whether Francais fondamental should be replaced by the the Threshold Level. (IFS/WGA)

  12. ExactDAS: an exact test procedure for the detection of differential alternative splicing in microarray experiments.

    PubMed

    Mary-Huard, Tristan; Jaffrezic, Florence; Robin, Stéphane

    2012-11-06

    The aim of this paper is to propose a test procedure for the detection of differential alternative splicing across conditions for tiling array or exon chip data. While developed in a mixed model framework, the test procedure is exact (avoiding computational burden) and applicable to a large variety of contrasts, including several previously published ones. A simulation study is presented to evaluate the robustness and performance of the method. It is found to have a good detection power of genes under differential alternative splicing, even for five biological replicates and four probes per exon. The methodology also enables the comparison of various experimental designs through exact power curves. This is illustrated with the comparison of paired and unpaired experiments. The test procedure was applied to two publicly available cancer data sets based on exon arrays, and showed promising results.

  13. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... divided as sub-ACLs between limited access vessels, limited access vessels that are fishing under a... limited access fishery sub-ACLs for fishing years 2011 through 2013 are: (A) 2011: 24,954 mt. (B) 2012: 26... catch, observer set-aside, and research set-aside, as specified in this paragraph (a). The LAGC ACLs...

  14. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... divided as sub-ACLs between limited access vessels, limited access vessels that are fishing under a LAGC... adjustment. (i) The limited access fishery sub-ACLs for fishing years 2014 and 2015 are: (A) 2014: 18,885 mt...). (i) The ACLs for fishing years 2014 and 2015 for LAGC IFQ vessels without a limited access...

  15. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... divided as sub-ACLs between limited access vessels, limited access vessels that are fishing under a LAGC... adjustment. (i) The limited access fishery sub-ACLs for fishing years 2013 and 2014 are: (A) 2013: 19,093 mt... paragraph (a). (i) The ACLs for fishing years 2013 and 2014 for LAGC IFQ vessels without a limited...

  16. The First Time/Das Erstes Mal: Approaches to Virginity Loss in U.S. and German Teen Magazines.

    ERIC Educational Resources Information Center

    Carpenter, Laura M.

    2001-01-01

    Examined 76 stories about virginity loss, using ethnographic content analysis, from German and U.S. teen magazines. A substantial proportion of all sexuality-related material in the magazines concerned virginity. Both publications depicted virginity loss as a unique, salient sexual turning point and made similar recommendations for virginity loss.…

  17. Das Konstanzer Trainingsmodell (KTM) - Grundlagen und neue Entwicklungen (The Konstanz Training Model (KTM) -- Fundamental Principles and Recent Developments).

    ERIC Educational Resources Information Center

    Dann, Hanns-Dietrich; Humpert, Winfried

    2002-01-01

    Summarizes the Konstanz Training Model (KTM), a German primary and secondary preventive program that increases teacher self-competence and social competence in dealing with aggressive and disruptive student behaviors. Emphasizes KTM's focus on systemic aspects, cognitive level, and behavioral level approaches. Describes KTM Compact, a short term…

  18. Ökophysik: Plaudereien über das Leben auf dem Land, im Wasser und in der Luft

    NASA Astrophysics Data System (ADS)

    Nachtigall, W.

    Prof. em. Dr. rer. nat. Werner Nachtigall, geb. 1934, war als Zoophysiologe und Biophysiker Leiter des Zoologischen Instituts der Universität des Saarlandes in Saarbrücken. In Forschung und Ausbildung hat er sich insbesondere mit Aspekten der Technischen Biologie und Bionik befasst und mit seinen Forschergruppen viele Basisdaten insbesondere zur Ökologie, Physiologie und Physik des Fliegens und Schwimmens aber auch zur Stabilität beispielsweise der Gräser erarbeitet. Lebewesen überraschen immer wieder durch ihre "Biodiversität", ihre hochspezifischen Ausgestaltungen und Anpassungen.

  19. Hepatologie Neuere Forschungsergebnisse in ihrer Bedeutung für das Verständnis von Leberkrankheiten

    NASA Astrophysics Data System (ADS)

    Gerok, W.; Blum, H. E.; Offensperger, W.; Offensperger, S.; Andus, T.; Groß, V.; Heinrich, P. C.

    1991-06-01

    By two exemplary clinical situations — acute viral hepatitis, acute-phase reaction of the liver — the significance of basic research for the understanding of clinical phenomena and for the development of new diagnostic and therapeutic procedures is demonstrated. The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. The proteins confine the local injury and establish the homeostasis of the organism.

  20. Das Pinealorgan der Wirbeltiere: ein Modell für Untersuchungen von Rezeptor-und Effektormechanismen in neuronalen Systemen

    NASA Astrophysics Data System (ADS)

    Korf, Horst-W.; Wicht, Helmut

    1991-10-01

    Cell and molecular biological investigations have greatly contributed to our understanding of receptor and effector mechanisms in sensory, neuronal, and endocrine cells. A fascinating aspect of this line of research is how such mechanisms have evolved and how they interact with each other. As shown in this contribution, the vertebrate pineal organ is an interesting model to study these problems, because it undergoes a conspicuous transformation during phylogeny, comprises two well-chraracterized receptor mechanisms (photoreception and adrenoreception), and acts upon its targets via neuronal and neuroendocrine signals.

  1. Werbung im Englischunterricht: Das Beispiel Einhorn - Onehorn - Unicorn (Advertising Material in English Teaching: The Example "Einhorn-Onehorn-Unicorn")

    ERIC Educational Resources Information Center

    Ruettgens, Hannelore

    1976-01-01

    Presents an advertisement from "Der Spiegel," composed in English that is saturated with Germanisms. Teaching procedures based on this are suggested: finding and classifying errors, composing alternative versions, translating into German, retranslating into English. Suggestions are given for further work based on the students' own…

  2. Eventorientierte Veranstaltungen und Lebensqualität innenstädtischer Wohnbevölkerung. Das Beispiel Bamberg

    NASA Astrophysics Data System (ADS)

    Redepenning, Marc; Rhein, Niklas; Sauerwald, David

    2016-09-01

    Events do have, in addition to economic effects, impact on the quality of life of the affected population. Using a case study from the city of Bamberg this article addresses the subjective contentment with larger events. The results show variation in the range of contentment depending on age and time of residency in the city. Furthermore, it becomes obvious that the particular expectation on "life in the inner city" shapes the contentment. Cities should pay attention to this social heterogeneity when deploying strategies of revitalisation through festivals and events. They should take it seriously by using tools of collaborative planning to preserve the multi-functionality of inner cities.

  3. Cloning and characterization of the DAS gene encoding the major methanol assimilatory enzyme from the methylotrophic yeast Hansenula polymorpha.

    PubMed

    Janowicz, Z A; Eckart, M R; Drewke, C; Roggenkamp, R O; Hollenberg, C P; Maat, J; Ledeboer, A M; Visser, C; Verrips, C T

    1985-05-10

    A gene library from the methanol utilizing yeast Hansenula polymorpha, constructed in a lambda Charon4A vector, was used to clone the gene encoding a key methanol assimilating enzyme, dihydroxyacetone synthase (DHAS) by differential plaque hybridization. The nucleotide sequence of the 2106 bp structural gene and the 5' and 3' non-coding regions was determined. The deduced amino acid sequence of the protein is in agreement with the apparent molecular weight and amino acid composition of the purified protein. The codon bias is not so pronounced as in some Saccharomyces cerevisiae genes.

  4. DAsHER CD: Developing a Data-Oriented Human-Centric Enterprise Architecture for EarthCube

    NASA Astrophysics Data System (ADS)

    Yang, C. P.; Yu, M.; Sun, M.; Qin, H.; Robinson, E.

    2015-12-01

    One of the biggest challenges that face Earth scientists is the resource discovery, access, and sharing in a desired fashion. EarthCube is targeted to enable geoscientists to address the challenges by fostering community-governed efforts that develop a common cyberinfrastructure for the purpose of collecting, accessing, analyzing, sharing and visualizing all forms of data and related resources, through the use of advanced technological and computational capabilities. Here we design an Enterprise Architecture (EA) for EarthCube to facilitate the knowledge management, communication and human collaboration in pursuit of the unprecedented data sharing across the geosciences. The design results will provide EarthCube a reference framework for developing geoscience cyberinfrastructure collaborated by different stakeholders, and identifying topics which should invoke high interest in the community. The development of this EarthCube EA framework leverages popular frameworks, such as Zachman, Gartner, DoDAF, and FEAF. The science driver of this design is the needs from EarthCube community, including the analyzed user requirements from EarthCube End User Workshop reports and EarthCube working group roadmaps, and feedbacks or comments from scientists obtained by organizing workshops. The final product of this Enterprise Architecture is a four-volume reference document: 1) Volume one is this document and comprises an executive summary of the EarthCube architecture, serving as an overview in the initial phases of architecture development; 2) Volume two is the major body of the design product. It outlines all the architectural design components or viewpoints; 3) Volume three provides taxonomy of the EarthCube enterprise augmented with semantics relations; 4) Volume four describes an example of utilizing this architecture for a geoscience project.

  5. Unternehmerische Verantwortung in der Stadt- und Regionalentwicklung. Einführung in das Themenheft "Corporate Regional Responsibility"

    NASA Astrophysics Data System (ADS)

    Kiese, Matthias; Schiek, Meike

    2016-03-01

    Firms assume increasing importance within co-operative modes of regional and urban governance. Further to just filling gaps left by the retreat of the welfare state, firms recognise the impact of their regional and local business environment on their performance, especially when it comes to attracting and retaining highly-skilled personnel. As an introduction to this issue, this contribution introduces the basic concept of corporate social responsibility and its regional variation, corporate regional responsibility.

  6. Fehler begehen - Mathematik verstehen Über die Bedeutung von Fehlern für das Verstehen

    NASA Astrophysics Data System (ADS)

    Käser, Udo

    Auch wenn eine historisch oder systematisch umfassende Darstellung zur Fehlerthematik bislang nicht vorliegt, ist die Idee, einer Fehleranalyse unter der Leitfrage, welche Fehler von Schülerinnen und Schülern aufgrund welcher epistemologischen Überzeugungen begangen werden, zentralen Raum für die Betrachtung von Verstehensprozessen einzuräumen, nicht neu. So ist es geradezu ein Charakteristikum einer modernen konstruktivistischen Didaktik, die eigenen Fehler von Lernenden als ihre individuellen Lerngelegenheiten zu begreifen, die einen wichtigen Motor für den subjektiven Lernfortschritt bilden. Diese Sichtweise wurzelt aus psychologischer Perspektive in Analysen in der Tradition Piagets, der in Abkehr von einer quantitativen, psychometrischen Beschreibung kognitiver Prozesse, wie sie sich zum Beispiel in Intelligenztheorien nach Binet findet, qualitativ zu beschreiben versuchte, in welcher Weise Kinder und Jugendliche denken und urteilen. Doch auch schon in der klassischen Philosophie sind entsprechende Ansätze zu finden. Prominente Beispiele hierfür sind die Idolenlehre Bacons und die Ideenlehre Platons.

  7. Bedeutung kleinräumiger Daten für die Evaluation von Bildungsprojekten. Das Beispiel der Junior Uni Wuppertal

    NASA Astrophysics Data System (ADS)

    Makles, Anna

    2016-12-01

    The Junior University, a University for children and youth in the city of Wuppertal, offers science courses that target children and youth from all socioeconomic backgrounds. The first evaluation study done by the University of Wuppertal in 2013 aimed at examining whether the Junior University has achieved this goal. The main challenge of our analysis was to approximate missing individual information on socioeconomic status by using spatial data. Therefore, we georeferenced address information of the Junior University students and linked those results to different characteristics available for about 2800 city blocks in the city of Wuppertal. We found out that indeed the Junior University succeeds in attracting children and youth from all socioeconomic backgrounds. The results show that many of the students live in poor neighborhoods or in neighborhoods with a high share of immigrants.

  8. A Utilização da Astronomia como Tema Interdisciplinar e Aplicações de Objetos de Aprendizagem

    NASA Astrophysics Data System (ADS)

    da Silva, L. A.; Voelzke, M. R.

    2008-09-01

    Este trabalho visa analisar a possibilidade de relacionar conteúdos aplicados no ensino fundamental e médio de forma interdisciplinar por intermédio da astronomia, com a intervenção de objetos de aprendizagem que possam integrar as disciplinas e a utilização de recursos tecnológicos. Em uma pesquisa prévia com 20 professores de uma escola estadual situada na cidade de Guarulhos foi observado que apenas 25% dos professores utilizam algum recurso tecnológico para o desenvolvimento de conteúdos pertinentes à sua disciplina, tais como sites e softwares educativos, sendo que a maioria absoluta continua ensinando apenas com livros didáticos. A maior parte dos professores apresenta dificuldades em trabalhar sua disciplina de forma interdisciplinar, ou seja, 75% dos professores preferem aplicar os conteúdos seguindo uma hierarquia linear de tópicos, evitando a discussão de temas que de alguma forma estão relacionados. A astronomia pode vir à fascinar o ser humano e despertar sua curiosidade promovendo um maior interesse no aprendizado, podendo favorecer análises interdisciplinares de forma lógica e objetiva, desta forma colocar a astronomia como tema motivador interdisciplinar, pode ser relevante no que se refere ao distanciamento da fragmentação dos conteúdos. No Estado de São Paulo, a implantação da proposta curricular no ensino fundamental e médio mostra claramente a inserção da astronomia na maior parte das séries, principalmente na 6ª série em que todo o bimestre se fala de astronomia.

  9. [Career Satisfaction of Medical Residents in Portugal].

    PubMed

    Martins, Maria João; Laíns, Inês; Brochado, Bruno; Oliveira-Santos, Manuel; Teixeira, Pedro Pinto; Brandão, Mariana; Cerqueira, Rui João; Castro-Ferreira, Ricardo; Bernardes, Carlos; Menezes, Miguel Nobre; Baptista, Bernardo Soares; Ladeiras-Lopes, Ricardo; Rei, Mariana Cruz; Rosa, Gilberto Pires da; Martins, José Luís; Mendonça Sanches, Maria; Ferreira-Pinto, Manuel J; Rato, Margarida; Costa e Silva, Miguel; Policiano, Catarina; Beato, João; Barbosa-Breda, João; Torres, João Pimentel; Leal, Inês; Rosa, Sílvia Aguiar; Ribeiro, Bárbara Carvalho; Costa, Francisco Rego; Palmela, Carolina; Gonçalves, Tiago Cúrdia; Morais, Luis; Marques, Tiago Reis

    2015-01-01

    Introdução: A satisfação com a profissão médica tem sido apontada como um fator essencial para a qualidade assistencial, o bemestar dos doentes e a estabilidade dos sistemas de saúde. Estudos recentes têm vindo a enfatizar um crescente descontentamento dos médicos, principalmente como consequência das alterações das relações laborais.Objetivos: Avaliar a perceção dos médicos de formação específica em Portugal, sobre as expectativas e grau de satisfação com a profissão, especialidade e local de formação; razões da insatisfação e intenção de emigrar.Material e Métodos: Estudo transversal. A colheita de dados foi efetuada entre Maio e Agosto de 2014 através de um Inquérito online sobre a âÄúSatisfação com a EspecialidadeâÄù.Resultados: De uma população total de 5788 médicos, foram obtidas 804 respostas (12,25% do total de médicos internos). Desta amostra, 77% das respostas correspondem a internos dos três primeiros anos de formação. Verificou-se que 90% dos médicos se encontram satisfeitos com a especialidade, tendo-se encontrado também níveis elevados de satisfação com a profissão (85%) e local de formação (86%). Por outro lado, constatou-se que estes diminuíam com a progressão ao longo dos anos de internato. A avaliação global sobre o panorama da prática médica foi negativa e 65% dos médicos responderam que consideram emigrar após conclusão do internato.Conclusão: Os médicos internos em Portugal apresentam níveis positivos de satisfação com a sua profissão. No entanto, a sua opinião sobre o panorama da Medicina e os resultados relativos à intenção de emigrar alertam para a necessidade de tomada de medidas para inverter este cenário.

  10. Evolução química de galáxias HII anãs

    NASA Astrophysics Data System (ADS)

    Ferraresi, M., Jr.; Cuisinier, F.; Telles, E.

    2003-08-01

    Galáxias HII anãs são galáxias de baixa massa, com alto conteúdo de gás, e se encontram em uma fase intensa de formação estelar. A taxa de formação estelar está tão alta nestas galáxias que não pode ter se mantido durante sua vida inteira. O tempo máximo de duração do episódio atual de formação estelar deve ser no máximo de algumas dezenas de milhões de anos, bem inferior à idade destas galáxias. Isto leva naturalmente a idéia de que já aconteceram surtos anteriores. Abundâncias químicas oferecem uma ferramenta poderosa para investigar a história evolutiva destas galáxias, porque aumentam de geração em geração estelar. O hidrogênio, o oxigênio, o nitrogênio produzem algumas das linhas mais importantes em um gás foto-ionizado, permitindo a determinação das abundâncias destes elementos facilmente. A dispersão das abundâncias em oxigênio e nitrogênio é significativa, sendo maior que os erros observacionais. O oxigênio é produzido em estrelas massivas, que explodem quase instâneamente, enquanto o nitrogênio é produzido em estrelas de massa intermediária, que só o liberam depois de um atraso de @ 500 mihões de anos. Construímos um modelo de evolução química semi-analítico, utilizando rendimentos empíricos baseados nas abundâncias observadas destes dois elementos. Conseguimos através deste modelo rudimentar explicar nas galáxias de mais baixas metalicidades as abundâncias de oxigênio e de nitrogênio, assim como a dispersão dos dados observacionais devida a formação estelar descontínua, e isto com um número baixo de surtos (1 ou 2, no máximo 3).

  11. Diferentes Metodologias Aplicadas ao Ensino de Astronomia

    NASA Astrophysics Data System (ADS)

    Albrecht, E.; Voelzke, M. R.

    2007-08-01

    Espera-se que o educando ao final da educação básica, adquira uma compreensão atualizada das hipóteses, modelos e formas de investigação sobre a origem e evolução do Universo em que vive. O presente trabalho tem como principal objetivo compreender dentre três práticas pedagógicas adotadas no Ensino de Astronomia, na terceira série do Ensino Médio, da Escola Estadual Colônia dos Pescadores, qual melhor cumpre o papel de formação e aprendizagem para vida. A pesquisa preliminar foi através de um questionário onde o intuito foi diagnosticar o conhecimento já existente acerca do tema em questão. O questionário é composto de vinte questões dissertativas e objetivas, onde os educandos das três turmas envolvidas o responderam. Este trabalho utiliza as seguintes metodologias: a tradicional, onde o professor é um repassador de informações, fazendo uso exclusivo de lousa e giz; a segunda também de forma tradicional, porém com auxílio de multimídia para desenvolvimento das aulas e aterceira sob forma de seminários, elaborados e apresentados pelos educandos, no qual o educador faz apenas as intervenções necessárias. Ao final do trabalho os alunos responderão novamente o questionário inicial para diagnosticar dentre as três metodologias utilizadas qual apresentou melhor resultado. Os resultados preliminares obtidos, já podem ser observados e, dos 119 alunos entrevistados, as respostas obtidas são as mais diversas e evidenciam que a grande maioria nunca teve em sua vida escolar o tema Astronomia. Ao serem questionados se já haviam estudado Astronomia as respostas foram: turma A: sim 43%; turma B: sim: 21%; turma C: sim: 24%. Porém quando questionados a respeito do significado de Astronomia observou-se que: turma A: 100% de acertos; turma B: 64% acertos; turma C: 84% de acertos, demonstrando claramente a aprendizagem em diferentes esferas, não dependendo unicamente da escola. Até o presente momento, verificou-se que há interesse em

  12. Condições físicas em galáxias HII

    NASA Astrophysics Data System (ADS)

    Kehrig, C.; Telles, E.; Cuisinier, F.

    2003-08-01

    Galáxias HII são galáxias anãs de baixa luminosidade que apresentam alta taxa de formação estelar. Seus espectros são dominados por intensas linhas de emissão devido à fotoionização pela presença de um grande número de estrelas do tipo O e B. Nós apresentamos um catálogo espectrofotométrico de 111 galáxias HII observadas no telescópio 1.52m do ESO com o espectrógrafo Boller & Chivens. Determinamos propriedades estatísticas da amostra e derivamos condições físicas (temperatura eletrônica, densidade eletrônica) e abundâncias químicas. Para algumas galáxias, fomos também capazes de resolver espacialmente regiões de formação estelar individuais e determinar propriedades espectroscópicas para estas regiões separadamente, o que nos permitiu avaliar as flutuações das condições físico-químicas dentro das galáxias HII. Em particular, vimos que apesar das galáxias HII apresentarem formação estelar espalhada ao longo do corpo da galáxia, são objetos quimicamente homogêneos. A fim de estudar a evolução temporal dos objetos durante o tempo de vida das estrelas ionizantes construimos também alguns diagramas relacionando razões de linhas de emissão com a largura equivalente de Hb (EW(Hb)). Para interpretar tais diagramas utilizamos modelos de fotoionização para populações estelares integradas. Concluímos que as galáxias HII não correspondem a simples idéia de um burst instantâneo envolvido por um gás opaco aos fótons ionizantes e com densidade constante. As relações observadas entre razões de linhas e EW(Hb) podem ser melhor compreendidas se as galáxias HII apresentarem populações estelares mais velhas, que contribuem para o contínuo óptico observado.

  13. Writing Using Blogs: A Way to Engage Colombian Adolescents in Meaningful Communication (La escritura a través de bitácoras o "blogs": una forma de involucrar a adolescentes colombianos en comunicación significativa)

    ERIC Educational Resources Information Center

    Rojas Álvarez, Gloria

    2011-01-01

    We report an action research project developed with ninth grade students of a public school in Bogotá, Colombia, and which focused on innovating English communication through writing blogs. The project took into account the implementation of a specific blog that proposes activities, suggestions, strategies and links, among other things, to…

  14. Ingestion Reiterada de Cuerpos Extranos. Forma Inusual de Presentacion del Sindrome de Munchausen por Poderes (Reiterated Ingestion of Foreign Bodies. Unusual Form of Presentation of Munchausen Syndrome by Proxy).

    ERIC Educational Resources Information Center

    Terreros, I. Gomez de; And Others

    1996-01-01

    An unusual case of Munchausen syndrome by proxy is reported. A mother with a psychiatric record of behavior disorders and family dysfunction perpetrated the ingestion of foreign bodies (for example, earrings, a screw, sewing needles) on a 10-month-old infant with a history of prematurity, repeated visits to emergency rooms, and nonjustified…

  15. Ingestion Reiterada de Cuerpos Extranos. Forma Inusual de Presentacion del Sindrome de Munchausen por Poderes (Reiterated Ingestion of Foreign Bodies. Unusual Form of Presentation of Munchausen Syndrome by Proxy).

    ERIC Educational Resources Information Center

    Terreros, I. Gomez de; And Others

    1996-01-01

    An unusual case of Munchausen syndrome by proxy is reported. A mother with a psychiatric record of behavior disorders and family dysfunction perpetrated the ingestion of foreign bodies (for example, earrings, a screw, sewing needles) on a 10-month-old infant with a history of prematurity, repeated visits to emergency rooms, and nonjustified…

  16. Situação da Mulher na Astronomia Brasileira

    NASA Astrophysics Data System (ADS)

    Silva, Adriana V. R.

    2007-07-01

    O conteúdo desse texto surgiu de uma apresentação de mesmo título que fiz na XXXI Reunião Anual da Sociedade Astronômica Brasileira (SAB) em 2005. Esse tema foi inspirado originalmente pela minha participação no "2nd UIPAP International Conference on Women in Physics" realizado entre 23 e 25 de maio de 2005 no Rio de Janeiro. Essa é uma conferência internacional que acontece de três em três anos, sendo que a primeira ocorreu em 2002 na cidade de Paris, França. Participei dessa conferência como membro da delegação da Sociedade Brasileira de Física e um dos trabalhos que apresentei versava sobre a situação das mulheres na Astronomia brasileira, cujos resultados principais discorro a seguir. A situação das astrônomas, baseada nos dados dos sócios da SAB coletados no final de 2004, é comparada com a das físicas brasileiras e também com as nossas colegas americanas. Os dados identificam ainda uma maior evasão da carreira por parte das mulheres do que os homens. Alguns dos possíveis motivos da evasão são discutidos, como o desejo de constituir família e/ou isolamento. Resultados um tanto preocupantes com relação à distribuição de bolsas de produtividade do CNPq também são apresentados. As principais discussões e estratégias recomendadas nesse congresso são mencionadas de forma resumida ao final.

  17. Estudo exaustivo e sistemático de erros nas provas da olimpíada brasileira de astronomia - resultados preliminares

    NASA Astrophysics Data System (ADS)

    Oliveira, F. S.; Canalle, J. B. G.; Villas da Rocha, J. F.

    2003-08-01

    A Olimpíada Brasileira de Astronomia (OBA) contou, em sua quinta edição, com a participação de mais de 60 mil alunos dos ensinos fundamental e médio de praticamente todo o território nacional. Uma das formas de controle que a sua coordenação nacional possui sobre a correção, levada a cabo pelos professores que as aplicaram, é a do envio, por parte destes professores, das 10 melhores provas de cada um dos três níveis nos quais a Olimpíada é realizada. Assim, e dado ao caráter discursivo das provas da Olimpíada, a sua coordenação nacional dispõe de um vasto acervo sobre as concepções, certas ou erradas, dos alunos que dela participaram. Este conjunto de dados jamais fora explorado até o presente trabalho que pretende ser, neste sentido, inaugural. Nas provas dos níveis I e II da V OBA, que abrangem todo o conjunto do ensino fundamental, uma das questões versava sobre a noção que os alunos tinham sobre como os habitantes da Terra situam-se sobre sua superfície. Fizemos um estudo sistemático das respostas a esta questão. Primeiramente, todas as modalidades de erros foram levantadas; em seguida, realizamos uma distribuição por idade tanto do índice de acerto como da ocorrência e da distribuição de cada erro. Como resultado, obtivemos que, em ambos os níveis: 1) as concepções errôneas não se apresentam distribuídas aleatoriamente; 2) há uma concentração no tipo de erro apresentado; 3) há uma tendência de progressivo acerto com relação à idade quando os dados são considerados em termos nacionais; 4) esta tendência nacional é fraca ou mesmo não é verificada em alguns dos estados com maior patamar de acerto.

  18. Axisymmetric rotational stagnation point flow impinging radially a permeable stretching/shrinking surface in a nanofluid using Tiwari and Das model.

    PubMed

    Roşca, Natalia C; Pop, Ioan

    2017-01-12

    In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters. From the stability analysis, it is found that the upper branch solution is stable, while the lower branch solution is unstable. Sample velocity and temperature profiles along both solution branches are graphically presented.

  19. Grüne Infrastruktur in den Städten Nordrhein-Westfalens. Bedeutung als Standortfaktor und Einfluss auf das Standortmarketing

    NASA Astrophysics Data System (ADS)

    Schäffer, Ina

    2016-06-01

    Hardly any other city in North Rhine-Westphalia has such a green image as the city of Münster. It embodies the image of a livable city in Germany. Other North Rhine-Westphalian cities also work on their external perception and are approaching the task of getting a greener image for themselves in many ways. A central question is how it is done precisely and whether urban green infrastructure can be a locational factor to affect location-based marketing. This article deals with the strategies of various cities in North Rhine-Westphalia.

  20. An analysis of seasonal changes in STE using measurements from the TOPSE campaign and the Beryllium-7 distribution from a calculation driven by the GEOS-3 DAS.

    NASA Astrophysics Data System (ADS)

    Allen, D. J.; Dibb, J. E.; Ridley, B.; Pickering, K. E.

    2002-05-01

    Measurements of tropospheric ozone (O3) between 30\\deg and 70\\deg N show springtime maxima at remote locations. The contribution of seasonal changes in stratosphere-troposphere exchange (STE) to these maxima was investigated using measurements from the Tropospheric Ozone Production about the Spring Equinox Experiment (TOPSE) campaign and the Beryllium-7 (7Be) distribution from a calculation driven by fields from the Goddard Earth Observing System Data Assimilation System. Comparison with TOPSE measurements revealed that upper tropospheric model-calculated 7Be mixing ratios were reasonable (a change from previous calculations) but that lower tropospheric mixing ratios were too low most likely due to an overestimation of scavenging. Temporal fluctuations were well captured although their amplitudes were often underestimated. Analysis of O3 measurements indicated that mixing ratios increased by 5-10% per month for θ < 300 K (the underworld) and by 10-15% per month for θ > 300 K (the tropospheric middleworld). 7Be mixing ratios decreased with time for θ < 290 K and increased with time for θ > 300 K. Model-calculated middleworld increases of 7Be were a factor of 2 less than measured increases. 7Be with a stratospheric source (strat-7Be) increased by 4.6-8.8% along TOPSE flight paths within the tropospheric middleworld. Increases in strat-7Be were not seen along TOPSE flight paths in the underworld. Assuming changes in O3 with a stratospheric source are the same as changes in strat-7Be and that 50% of O3 is produced in the stratosphere, changes in STE explain 20-60% of O3 increases in the tropospheric middleworld and less than 30% of O3 increases in the underworld.

  1. Mājsaimniecību Ietekme uz Klimatu Latvijā: Oglekļa Pēdas Rādītājs

    NASA Astrophysics Data System (ADS)

    Brizga, J.; Kudreņickis, I.

    2009-01-01

    People more and more recognize climate change as one of the main environmental problems and the term `carbon footprint' (CF) has become popular and is now in widespread use. In this paper, the CF concept has been applied to analyse average per capita household Greenhouse Gas (GHG) emissions in Latvia. We explore household CF in housing (heating and electricity consumption), transport, food and goods and service sectors, which are the main household environmental pressure areas. This paper provides an understanding of both direct and indirect (embodied) GHG emissions. Results from the study suggest that the average Latvian exceeds its global fair share of GHG emissions - the average per capita GHG in 2006 was 4.35 t CO2e. The highest household emissions arise from housing (37%), mobility (26%) and food consumption (25%), goods and services together account only for 12% of total household GHG emissions. This study, however, does not cover capital investments in infrastructure (roads, public buildings etc.) which could increase total emission by almost a ton. The study emphasizes that attention must be paid to the lifestyles, infrastructure and institutions that result in considerable amounts of carbon being locked up in the household activities through which people meet their everyday needs. The findings also indicate that policies should be targeted at the segments in society responsible for the highest carbon footprints, ie. housing, food and mobility.

  2. Efeitos dos sais na planta e tolerância das culturas à salinidade (Salinity effects on plants and tolerance of crops to salinity)

    USDA-ARS?s Scientific Manuscript database

    The major challenge for world agriculture today is to maintain food and water supplies that can meet the demands of a growing world population. The shortage of fresh water, and its use mainly for human consumption, leaves the farmers with the choice of using reclycled city water, or underground sali...

  3. Mobilitätslösungen für den ländlichen Raum. Das Beispiel VSB Verkehrsverbund Schwarzwald-Baar in Baden-Württemberg

    NASA Astrophysics Data System (ADS)

    Mager, Thomas J.

    2017-09-01

    The current public transport situation in rural areas is characterized by strong changes in legal, economic, demographic and above all political influence factors. In Baden-Württemberg, student transportation funding has changed as part of the municipalization of compensation payments pursuant to § 45a of the Public Transportation Act. This will affect public transportation in rural areas, especially in the southern Baden region, which accounts for 80% of all rural public transportation. In order to maintain public transportation in rural areas, new models of long-term financing independent of student numbers should be developed and applied in combination with alternative and less traditional service offerings. This article discusses the example of the VSB transport association Schwarzwald-Baar, which offers mobility solutions in rural areas.

  4. Lemaître, the expanding universe, and the cosmological constant (German Title: Lemaître, das expandierende Universum und die kosmologische Konstante )

    NASA Astrophysics Data System (ADS)

    Roessler, Kurt

    The scientific and human relations of Albert Einstein and Georges Lemaître are discussed. In 1927 the later had interpreted the general theory of relativity for a model of an expanding cosmos using a positive value of the cosmological constant. In the three open questions between them: expansion of cosmos, primordial state of a quantum vacuum (``primeval atom''), importance of the cosmological constant for vacuum energy, Lemaître finally won over the heavily opposing Einstein. The philosophical and ontological tendency of Einstein's thinking was contrasted with the strict epistemological line of the catholic priest Lemaître. The dramatic changes between friendship and controversy finally led to a diminution of Lemaître's reputation as ``Darwin of Cosmology''. In that case, the late Einstein proved to be a hindrance rather than a promoter of evolution in cosmology.

  5. Axisymmetric rotational stagnation point flow impinging radially a permeable stretching/shrinking surface in a nanofluid using Tiwari and Das model

    NASA Astrophysics Data System (ADS)

    Roşca, Natalia C.; Pop, Ioan

    2017-01-01

    In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters. From the stability analysis, it is found that the upper branch solution is stable, while the lower branch solution is unstable. Sample velocity and temperature profiles along both solution branches are graphically presented.

  6. [Hospital bacteremia at the "Instituto do Coração do Hospital das Clínicas da FMUSP": a four-year retrospective study].

    PubMed

    Camargo, L F; Strabelli, T M; Ribeiro, F G; Mendes, C M; Uip, D E; Bellotti, G M; Pileggi, F J

    1994-01-01

    We conducted a retrospective study to establish mortality rates and prevalence of nosocomial bacteremias at our institute. We found 1.21 nosocomial bacteremias per 100 hospital discharges with an overall Mortality rate of 29.5%. Primary bacteremias increased during the four-year-study-period from 31 to 41%. Staphylococcus, both coagulase-positive and coagulase-negative, was the bacteria most frequently isolated. An abrupt increase in the isolation of P.aeruginosa occurred in 1992. We concluded that a blood-culture surveillance program is required for determining an endemic rate.

  7. Die regionalökonomische Bedeutung der Wissenschaft für das Ruhrgebiet. Hochschulen und außeruniversitäre Forschungseinrichtungen als Motor der regionalen Entwicklung

    NASA Astrophysics Data System (ADS)

    Kriegesmann, Bernd; Böttcher, Matthias; Lippmann, Torben

    2016-09-01

    The Ruhr area has advanced to the largest university region in Germany - often unnoticed within and outside. At the same time scientific institutions have become a major economic factor. Because of the higher and extra-university research institutions about 2.5 billion euros are effective as a demand potential in the region. 1.7 billion euros of this amount are directly associated with investments and operating expenditures of the scientific institutions as well as consumptions of employees and students. Additional 770 million euros result in revenues of many branches such as trade, housing, gastronomy sector, handcraft industry etc. It should not be underestimated that higher and extra-university research institutions generate with their research activities particular funding from the European Union or the rest of Germany for benefit of the region. Each euro spent by the state government for basic funding creates 39 cents third-party funding. These regional-economic effects result in noticeable employment impacts within the region. Around 25,000 people are directly employed in higher and extra-university research institutes or student unions (Studierendenwerke), about 22,000 jobs in other economic sectors are ensured or created by the induced demand. Science has thus become an important economic factor and represents an essential counterbalance to employment decline in shrinking industries of the region. The specific inclusion of science in a regional development strategy and targeted relining with appropriate measures to strengthen the science creates therefore an effective starting point for the design of structural change.

  8. Längengrad. Die wahre Geschichte eines einsamen Genies, welches das größte wissenschaftliche Problem seiner Zeit löste.

    NASA Astrophysics Data System (ADS)

    Sobel, D.

    This book is a German translation, by M. Fienbork, from the American original "Longitude", published in 1995. It tells the story of John Harrison (1693 - 1776), the inventor of a chronometer for precise time determination onboard of ships.

  9. Conceptual design of the CZMIL data acquisition system (DAS): integrating a new bathymetric lidar with a commercial spectrometer and metric camera for coastal mapping applications

    NASA Astrophysics Data System (ADS)

    Fuchs, Eran; Tuell, Grady

    2010-04-01

    The CZMIL system is a new generation airborne bathymetric and topographic remote sensing platform composed of an active lidar, passive hyperspectral imager, high resolution frame camera, navigation system, and storage media running on a linux-based Gigabit Ethernet network. The lidar is a hybrid scanned-flash system employing a 10 KHz green laser and novel circular scanner, with a large aperture receiver (0.20m) having multiple channels. A PMT-based segmented detector is used on one channel to support simultaneous topographic and bathymetric data collection, and multiple fields-of- view are measured to support bathymetric measurements. The measured laser returns are digitized at 1 GHz to produce the waveforms required for ranging measurements, and unique data compression and storage techniques are used to address the large data volume. Simulated results demonstrate CZMIL's capability to discriminate bottom and surface returns in very shallow water conditions without compromising performance in deep water. Simulated waveforms are compared with measured data from the SHOALS system and show promising expected results. The system's prototype is expected to be completed by end of 2010, and ready for initial calibration tests in the spring of 2010.

  10. Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) – short version

    PubMed Central

    Baron, Ralf; Binder, Andreas; Biniek, Rolf; Braune, Stephan; Buerkle, Hartmut; Dall, Peter; Demirakca, Sueha; Eckardt, Rahel; Eggers, Verena; Eichler, Ingolf; Fietze, Ingo; Freys, Stephan; Fründ, Andreas; Garten, Lars; Gohrbandt, Bernhard; Harth, Irene; Hartl, Wolfgang; Heppner, Hans-Jürgen; Horter, Johannes; Huth, Ralf; Janssens, Uwe; Jungk, Christine; Kaeuper, Kristin Maria; Kessler, Paul; Kleinschmidt, Stefan; Kochanek, Matthias; Kumpf, Matthias; Meiser, Andreas; Mueller, Anika; Orth, Maritta; Putensen, Christian; Roth, Bernd; Schaefer, Michael; Schaefers, Rainhild; Schellongowski, Peter; Schindler, Monika; Schmitt, Reinhard; Scholz, Jens; Schroeder, Stefan; Schwarzmann, Gerhard; Spies, Claudia; Stingele, Robert; Tonner, Peter; Trieschmann, Uwe; Tryba, Michael; Wappler, Frank; Waydhas, Christian; Weiss, Bjoern; Weisshaar, Guido

    2015-01-01

    In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published the “Evidence- and Consensus-based Guidelines on the Management of Analgesia, Sedation and Delirium in Intensive Care”. Since then, several new studies and publications have considerably increased the body of evidence, including the new recommendations from the American College of Critical Care Medicine (ACCM) in conjunction with Society of Critical Care Medicine (SCCM) and American Society of Health-System Pharmacists (ASHP) from 2013. For this update, a major restructuring and extension of the guidelines were needed in order to cover new aspects of treatment, such as sleep and anxiety management. The literature was systematically searched and evaluated using the criteria of the Oxford Center of Evidence Based Medicine. The body of evidence used to formulate these recommendations was reviewed and approved by representatives of 17 national societies. Three grades of recommendation were used as follows: Grade “A” (strong recommendation), Grade “B” (recommendation) and Grade “0” (open recommendation). The result is a comprehensive, interdisciplinary, evidence and consensus-based set of level 3 guidelines. This publication was designed for all ICU professionals, and takes into account all critically ill patient populations. It represents a guide to symptom-oriented prevention, diagnosis, and treatment of delirium, anxiety, stress, and protocol-based analgesia, sedation, and sleep-management in intensive care medicine. PMID:26609286

  11. [Hospitalizations at Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, USP, 1996-2003].

    PubMed

    Chaves, Lucieli Dias Pedreschi; Laus, Ana Maria; Anselmi, Maria Luiza

    2009-03-01

    Hospitalizations represent an important share of healthcare, due to both the complexity of actions and the financial volume applied. This descriptive-exploratory investigation had the purpose to identify and describing the physical and financial production of hospitalizations performed in a school hospital in the state of São Paulo, from 1996 to 2003, focusing the specialties of surgical clinic, medical clinic, pediatrics and obstetrics. Data collection was performed by searching the official databanks of the studied institution. In that period, a global 8.5% reduction in the frequency of admittances and a 78.4% increase in the financial resources were observed. Surgical clinic, with more expensive procedures, increased its admittances; the production in obstetrics showed the lowest variation. The increasing incorporation of technology, the demands from regional users and the migration of users from the supplementary system to the SUS may justify the variation of production in the different specialties.

  12. Coronary artery disease treatment in dialysis patients at the Hospital das Clínicas da Faculdade de Medicina de Botucatu--UNESP.

    PubMed

    Vieira, Paula Ferreiro; Garcia, Paula Dalsoglio; Bregagnollo, Edson Antonio; Carvalho, Fábio Cardoso; Kochi, Ana Cláudia; Martins, Antonio Sérgio; Caramori, Jaqueline Costa Teixeira; Franco, Roberto Jorge da Silva; Barretti, Pasqual; Martin, Luis Cuadrado

    2007-05-01

    Interventional treatment of coronary insufficiency is underemployed among dialysis patients. Studies confirming its efficacy in this set of patients are scarce. To assess the results of interventional treatment of coronary artery disease in patients undergoing dialysis. A total of 34 dialysis patients submitted to coronary angiography between September 1995 and October 2004 were divided according to presence or absence of coronary lesion, type of treatment and presence or absence of diabetes mellitus. The groups were compared according to their clinical and survival characteristics. Survival of patients undergoing interventional treatment was compared to overall survival of 146 dialysis patients at the institution in the same period. Interventional treatment was indicated to the same clinical conditions in the general population. Thirteen patients with no angiography coronary lesions presented a survival rate of 100% in 48 months as compared to 35% of 21 patients with coronary artery disease. Diabetic patients had a lower survival rate compared with non-diabetics. Angioplasty had a worse prognosis compared to surgery; however, 80% of patients undergoing angioplasty were diabetic. Seventeen patients submitted to interventional procedures presented a survival rate similar to that of the others 146 hemodialysis patients without clinical evidence of coronary disease. This small series shows that myocardial revascularization, whenever indicated, can be performed in dialysis patients. This conclusion is corroborated by similar mortality rates in two groups of patients: coronary patients submitted to revascularization and overall dialysis patients.

  13. Das Blüte-Bestäuber-Netz auf Brachflächen : biozönologische Untersuchung zur Bedeutung von Brachen in einer intensiv genutzten Agrarlandschaft

    NASA Astrophysics Data System (ADS)

    Hahn, Robert

    2002-11-01

    In der vorliegenden Dissertation wird die Bedeutung von Brachen für Artenvielfalt und Stabilität von Blüte-Bestäuber-Nahrungsnetzen in agrarisch genutzten Landschaften anhand ausgewählter blütenbesuchender Insektengruppen (Syrphidae, Lepidoptera) untersucht. Die Freilandarbeiten fanden von 1998-2000 im Raum der Feldberger Seenlandschaft, Mecklenburg-Vorpommern, statt. Es werden die beiden Hauptnahrungsquellen Nektar und Pollen betrachtet, dabei fanden Untersuchungen zur Intensität der Blüte-Bestäuber-Interaktion auf Stilllegungsflächen, zum flächenbezogenen quantitativen Nektarangebot im Jahresverlauf, zur individuellen Pollennutzung bei Syrphiden und zur Breite und Überlappung der Nahrungsnischen bei den dominanten Arten Episyrphus balteatus, Metasyrphus corollae, Syritta pipiens und Sphaerophoria scripta statt. Im Ergebnis zeigt sich eine hohe Bedeutung der Brachflächen für die Stabilität des Blüte-Bestäuber-Netzes, während die Diversität von anderen, eher landschaftsbezogenen Faktoren abhängig ist. This dissertation examines the importance of fallow land for the diversity and stability of pollination webs in agricultural landscapes as exemplified by selected groups of anthophilous insects (syrphidae and lepidoptera). The field studies were carried out between 1998 and 2000 in the Feldberg lakeland area in the north-east German State of Mecklenburg-Western Pomerania. Observations were made of nectar and pollen as the two main sources of food. Studies were conducted into the intensity of plant-pollinator interaction in set-aside areas, the site-specific quantity of nectar available during the vegetation period and the individual pollen intake of syrphid flies. Different methods were employed to establish the breadth of the trophic niches among the predominant species (Episyrphus balteatus, Metasyrphus corollae, Syritta pipiens and Sphaerophoria scripta) and the extent to which they overlapped. The studies showed that, while fallow land is very important for the stability of plant-pollinator food webs, their diversity depends on other factors that are more closely related to the landscape.

  14. X Marks the Spot--Not: Pirate Treasure Maps in "Treasure Island" and "Käpt'n Sharky und das Geheimnis der Schatzinsel"

    ERIC Educational Resources Information Center

    Zähringer, Raphael

    2017-01-01

    This article explores the functions of paratextual and intra-textual pirate treasure maps in works of literature for children and young adults. Based on an examination of how the indexical X that "marks the spot" operates as the focal point of the semiotic endeavours of treasure maps, the article outlines the fragile stance of maps…

  15. Elektroninės cigaretės: naujas būdas mesti rūkyti ar nauja grėsmė?

    PubMed Central

    Aistė, Aleknaitė; Monika, Andrijauskaitė; Justė, Latauskienė; Viktorija, Andrejevaitė

    2016-01-01

    Nuo 2010 m. tarp suaugusiųjų ir paauglių išaugo elektroninių cigarečių vartojimas. Dauguma el. cigarečių vartotojų anksčiau yra rūkę tradicinius tabako gaminius. Didžioji dalis žmonių el. cigaretes suvokia kaip priemonę, padėsiančią mesti rūkyti ar sumažinti surūkomų įprastinių cigarečių kiekį. Elektroninės cigaretės yra prietaisas, susidedantis iš skysčiu užpildytos kasetės, kaitiklio bei baterijos. Nuspaudus mygtuką įjungiamas kaitiklis, kuris šildo skystį, o, šiam tapus garais, jie įkvepiami. Visų rūšių el. skysčių pagrindinės sudedamosios dalys yra glicerolis arba propileno glikolis, papildomai gali būti pridedama nikotino ir / ar aromatų. Skysčiuose taip pat nustatyta įvairių kitų cheminių medžiagų. Ilgalaikio el. cigarečių vartojimo pasekmės sveikatai nėra išaiškintos, manoma, kad jos turėtų būti saugesnės nei rūkyti įprastines cigaretes. Nėra pakankamai ištirtas el. cigarečių skysčiuose esančių medžiagų toksiškumas. Trūksta duomenų apie el. cigarečių, kaip pagalbinės priemonės norint mesti rūkyti, veiksmingumą ir saugumą. Gydytojas norinčiam mesti rūkyti pacientui pirmiausia turėtų pasiūlyti patvirtintas pakaitinės nikotino terapijos ar kitas pagalbines priemones ir užtikrinti, kad pacientas gautų informaciją apie naujausius medikamentus, galinčius jam padėti. Jei pacientas atsisako šių priemonių ir renkasi el. cigaretes, gydytojas turėtų informuoti apie abejotiną jų saugumą ir veiksmingumą. Visuomenėje kyla susirūpinimas, kad el. cigarečių rūkymas gali paskatinti priklausomybę nikotinui ir padidinti norą išbandyti įprastines cigaretes. Nerimą kelia ir neapribotas el. cigarečių vartojimas viešosiose vietose. Nėra žinoma, kokią įtaką aplinkinių sveikatai gali turėti pasyvus garinimas. El. cigarečių reglamentavimas visame pasaulyje skiriasi ir laikui bėgant kinta. PMID:28356791

  16. Axisymmetric rotational stagnation point flow impinging radially a permeable stretching/shrinking surface in a nanofluid using Tiwari and Das model

    PubMed Central

    Roşca, Natalia C.; Pop, Ioan

    2017-01-01

    In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters. From the stability analysis, it is found that the upper branch solution is stable, while the lower branch solution is unstable. Sample velocity and temperature profiles along both solution branches are graphically presented. PMID:28079124

  17. Comment on `Magnitude conversion problem using general orthogonal regression' by H. R. Wason, Ranjit Das and M. L. Sharma, (Geophys. J. Int., 190, 1091-1096)

    NASA Astrophysics Data System (ADS)

    Gasperini, Paolo; Lolli, Barbara

    2014-01-01

    The argument proposed by Wason et al. that the conversion of magnitudes from a scale (e.g. Ms or mb) to another (e.g. Mw), using the coefficients computed by the general orthogonal regression method (Fuller) is biased if the observed values of the predictor (independent) variable are used in the equation as well as the methodology they suggest to estimate the supposedly true values of the predictor variable are wrong for a number of theoretical and empirical reasons. Hence, we advise against the use of such methodology for magnitude conversions.

  18. Folgen des Globalen Wandels für das Grundwasser in Süddeutschland - Teil 2: Sozioökonomische Aspekte

    NASA Astrophysics Data System (ADS)

    Barthel, Roland; Krimly, Tatjana; Elbers, Michael; Soboll, Anja; Wackerbauer, Johann; Hennicker, Rolf; Janisch, Stephan; Reichenau, Tim G.; Dabbert, Stephan; Schmude, Jürgen; Ernst, Andreas; Mauser, Wolfram

    2011-12-01

    In order to account for complex interactions between humans climate and the water cycle, the research consortium GLOWA-Danube (www.glowa-danube.de) has developed the simulation system DANUBIA which consists of 17 coupled models. DANUBIA was applied to investigate various impacts of global-change between 2011 and 2060 in the Upper Danube Catchment. This article describes part 2 of an article series with investigations of socio-economic aspects, while part 1 (Barthel et al. in Grundwasser 16(4), doi:10.1007/s007-011-01794, 2011) deals with natural-spatial aspects. The principles of socio-economic actor-modeling and interactions between socio-economic and natural science model components are described here. We present selected simulations that show impacts on groundwater from changes in agriculture, tourism, economy, domestic water users and water supply. Despite decreases in water consumption, the scenario simulations show significant decreases in groundwater quantity. On the other hand, groundwater quality will likely be influenced more severely by land use changes compared to direct climatic causes. However, overall changes will not be dramatic.

  19. Folgen des Globalen Wandels für das Grundwasser in Süddeutschland - Teil 1: Naturräumliche Aspekte

    NASA Astrophysics Data System (ADS)

    Barthel, Roland; Reichenau, Tim G.; Muerth, Markus; Heinzeller, Christoph; Schneider, Karl; Hennicker, Rolf; Mauser, Wolfram

    2011-12-01

    In order to account for complex interactions between humans climate and the water cycle, the research consortium GLOWA-Danube (www.glowa-danube.de) has developed the simulation system DANUBIA which consists of 17 coupled models. DANUBIA was applied to investigate various impacts of global-change between 2011 and 2060 in the Upper Danube Catchment. This article represents part 1 of an article series and describes groundwater and natural aspects of the investigations, while part 2 describes socio-economic aspects (Barthel et al. in Grundwaser 16(4), doi:10.1007/s00767-011-0180-y, 2011). Here we describe concepts of GLOWA-Danube and DANUBIA as well as groundwater-related model components. This leads to selected simulation results for water balance, groundwater quantity and quality. The chosen scenarios show decreasing precipitation, increasing temperatures, and changes in the annual distribution that lead to significant decreases in groundwater recharge. Regional predictions of groundwater quality were difficult to achieve because of complex soil and groundwater processes. However, climatic change will probably have little impact.

  20. "Der Andere" und "Das Andere" als Problem und Aufgabe von Erziehung und Bildung ("The Other Individual" and "The Other" as a Problem and a Task of Education).

    ERIC Educational Resources Information Center

    Benner, Dietrich

    1999-01-01

    Examines the common division in pedagogical discourse of the other as either (1) male or female individual or (2) the world beyond the subject. Proposes an approach that examines both forms of otherness in relation to each other. Addresses the significance for pedagogical theory and practice. (CMK)

  1. Proceedings of the NATO Advanced Study Institute on Atmospheric Ozone: Its Variation and Human Influences, Aldeia das Acoteias, Algarve, Portugal, October 1-13, 1979,

    DTIC Science & Technology

    1980-05-01

    conditions, J. Geophys. Res., 82, 5923-5927, 1977. Hameed, S., J. P. Pinto and R. W. Stewart, Sensitivity of the predicted CO-OH-CH4 perturba- tion to...Systems of the World, Cambridge University Press, 1974. Hameed, S., J.P. Pinto , R.W. Stewart, Sensitivity of the Predicted CO-OH-CH4 Perturbation to...sensitized decomposition of 03: The reactions of CIO and 0CZO with 031 J. Photochem. 10, 163-186, 1979. 465 WATSON Yung, Y. L., P. J. Pinto , R. T

  2. "About the Telescope" and other manuscripts of lectures by Christoph Scheiner. (German Title: "Über das Fernrohr" und weitere Mitschriften von Vorlesungen Christoph Scheiners)

    NASA Astrophysics Data System (ADS)

    Daxecker, Franz

    "About the Telescope" is a manuscript of a lecture which was held by Christoph Scheiner in Ingolstadt around 1615. It has been translated from Latin. The manuscript gives an account of the invention, the construction, the manufacture and the use of the telescope. There is also a reference to 3 more manuscripts (19 topics about astronomy and physics) of his lectures.

  3. Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version.

    PubMed

    Baron, Ralf; Binder, Andreas; Biniek, Rolf; Braune, Stephan; Buerkle, Hartmut; Dall, Peter; Demirakca, Sueha; Eckardt, Rahel; Eggers, Verena; Eichler, Ingolf; Fietze, Ingo; Freys, Stephan; Fründ, Andreas; Garten, Lars; Gohrbandt, Bernhard; Harth, Irene; Hartl, Wolfgang; Heppner, Hans-Jürgen; Horter, Johannes; Huth, Ralf; Janssens, Uwe; Jungk, Christine; Kaeuper, Kristin Maria; Kessler, Paul; Kleinschmidt, Stefan; Kochanek, Matthias; Kumpf, Matthias; Meiser, Andreas; Mueller, Anika; Orth, Maritta; Putensen, Christian; Roth, Bernd; Schaefer, Michael; Schaefers, Rainhild; Schellongowski, Peter; Schindler, Monika; Schmitt, Reinhard; Scholz, Jens; Schroeder, Stefan; Schwarzmann, Gerhard; Spies, Claudia; Stingele, Robert; Tonner, Peter; Trieschmann, Uwe; Tryba, Michael; Wappler, Frank; Waydhas, Christian; Weiss, Bjoern; Weisshaar, Guido

    2015-01-01

    In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published the "Evidence- and Consensus-based Guidelines on the Management of Analgesia, Sedation and Delirium in Intensive Care". Since then, several new studies and publications have considerably increased the body of evidence, including the new recommendations from the American College of Critical Care Medicine (ACCM) in conjunction with Society of Critical Care Medicine (SCCM) and American Society of Health-System Pharmacists (ASHP) from 2013. For this update, a major restructuring and extension of the guidelines were needed in order to cover new aspects of treatment, such as sleep and anxiety management. The literature was systematically searched and evaluated using the criteria of the Oxford Center of Evidence Based Medicine. The body of evidence used to formulate these recommendations was reviewed and approved by representatives of 17 national societies. Three grades of recommendation were used as follows: Grade "A" (strong recommendation), Grade "B" (recommendation) and Grade "0" (open recommendation). The result is a comprehensive, interdisciplinary, evidence and consensus-based set of level 3 guidelines. This publication was designed for all ICU professionals, and takes into account all critically ill patient populations. It represents a guide to symptom-oriented prevention, diagnosis, and treatment of delirium, anxiety, stress, and protocol-based analgesia, sedation, and sleep-management in intensive care medicine.

  4. Das Bin Ich. Ein Buch von mir uber mich (It's Me! A Book By and About Myself). Communicative Activities for German Immersion and Second Language Classes.

    ERIC Educational Resources Information Center

    Wicke, Mariele; Wicke, Rainer

    This workbook is intended as a text for the learner of German as a foreign language. The workbook is complete with exercises that require students to provide information about themselves. Students provide information by reading questions and filling in the blanks. Questions are asked about families, friends, likes and dislikes, hobbies, and even…

  5. Kooperatives Lernen lernen? Zur Diskussion uber das Bildungswesen in Japan (Learning Cooperative Learning? On the Discussion of the Japanese Educational System).

    ERIC Educational Resources Information Center

    Schubert, Volker

    1998-01-01

    Suggests a reconsideration of the criticism of Japanese competition against the background of the Japanese educational system's highly developed learning culture. Considers some of the basic aspects of group-oriented communal learning in school, while also cautioning against a "monocausal" culturalism. (Author/CMK)

  6. Das Bin Ich. Ein Buch von mir uber mich (It's Me! A Book By and About Myself). Communicative Activities for German Immersion and Second Language Classes.

    ERIC Educational Resources Information Center

    Wicke, Mariele; Wicke, Rainer

    This workbook is intended as a text for the learner of German as a foreign language. The workbook is complete with exercises that require students to provide information about themselves. Students provide information by reading questions and filling in the blanks. Questions are asked about families, friends, likes and dislikes, hobbies, and even…

  7. Kooperatives Lernen lernen? Zur Diskussion uber das Bildungswesen in Japan (Learning Cooperative Learning? On the Discussion of the Japanese Educational System).

    ERIC Educational Resources Information Center

    Schubert, Volker

    1998-01-01

    Suggests a reconsideration of the criticism of Japanese competition against the background of the Japanese educational system's highly developed learning culture. Considers some of the basic aspects of group-oriented communal learning in school, while also cautioning against a "monocausal" culturalism. (Author/CMK)

  8. Our Day-Care Centers Respect Children: Quality Criteria for Day-Care = Criterios para um Atendimento em Creches que Respeite os Direitos Fundamentais das Criancas.

    ERIC Educational Resources Information Center

    Campos, Maria Malta; Rosemberg, Fulvia

    Prepared as part of an effort to attain minimum quality standards for Brazilian day care centers, this document focuses on day-to-day provision of day care services for children from birth to 6 years old as well as broader day care administrative concerns. The first version of this document was prepared as part of a training project for day care…

  9. Immunodetection of Triticum mosaic virus by DAS- and DAC-ELISA using antibodies produced against coat protein expressed in Escherichia coli: potential for high-throughput diagnostic methods.

    PubMed

    Tatineni, Satyanarayana; Sarath, Gautam; Seifers, Dallas; French, Roy

    2013-04-01

    Triticum mosaic virus (TriMV), an economically important virus infecting wheat in the Great Plains region of the USA, is the type species of the Poacevirus genus in the family Potyviridae. Sensitive and high-throughput serology-based detection methods are crucial for the management of TriMV and germplasm screening in wheat breeding programs. In this study, TriMV coat protein (CP) was expressed in Escherichia coli, and polyclonal antibodies were generated against purified soluble native form recombinant CP (rCP) in rabbits. Specificity and sensitivity of resulting antibodies were tested in Western immuno-blot and enzyme-linked immunosorbent assays (ELISA). In direct antigen coating (DAC)-ELISA, antibodies reacted specifically, beyond 1:20,000 dilution with TriMV in crude sap, but not with healthy extracts, and antiserum at a 1:10,000 dilution detected TriMV in crude sap up to 1:4860 dilution. Notably, rabbit anti-TriMV IgG and anti-TriMV IgG-alkaline phosphatase conjugate reacted positively with native virions in crude sap in a double antibody sandwich-ELISA, suggesting that these antibodies can be used as coating antibodies which is crucial for any 'sandwich' type of assays. Finally, the recombinant antibodies reacted positively in ELISA with representative TriMV isolates collected from fields, suggesting that antibodies generated against rCP can be used for sensitive, large-scale, and broad-spectrum detection of TriMV.

  10. Molecular characterization of van genes found in vancomycin-resistant Enterococcus spp. isolated from the Hospital das Clínicas, FMUSP, São Paulo, Brazil.

    PubMed

    Caiaffa Filho, H H; Almeida, G D; Oliveira, G A; Sarahyba, L; Mamizuka, E M; Burattini, M N

    2003-06-01

    Vancomycin-resistant enterococci strains (VRE) is an important pathogen related with hospital infections in many countries, presenting limited or no therapeutic options for treating serious infections. VRE has presented some different genotypes been VanA and VanB considered to be the most important in hospital environments. In the present study the authors investigated the prevalence of van genes (A, B an C) among clinical isolates of VRE in a five month period at a large tertiary hospital in Sao Paulo, Brazil. The results showed the presence of vanA, but not vanB or vanC in all 43 strains of E. faecalis and five E. faecium studied. The results bring an important issue, due to the possibility of resistance spread of vanA genes, to be monitored and solved by the hospital infection control team and the microbiology and molecular biology laboratories at tertiary Hospitals.

  11. Educational Planning and Management in Small States [and] De la viabilite au developpement durable: role et perpectives de la planification de l'education das les petits Etates.

    ERIC Educational Resources Information Center

    Bray, Mark; Atchoarena, David

    Part of Round Table IV, this document consists of two articles presented at an international congress in Mexico. Each deals with planning and management of education in small countries. The purpose of the congress was to review the evolution of educational planning and management since a previous conference held in 1968. The participants hoped to…

  12. Antarktis: Das CCAMLR-Übereinkommen (Convention on the Conservation of Antarctic Marine Living Resources) und die illegale Überfischung der südlichen Ozeane

    NASA Astrophysics Data System (ADS)

    Siegel, Volker

    1999-12-01

    The Convention for the Conservation of Antarctic Marine Living Resources (CCAMLR) was ratified in 1982. This Convention was established in the light of a rapidly developing krill fishery in the 1970’s. The objectives of the Convention are the rational use of marine living resources as well as the conservation of the resources and the marine ecosystem. Establishing the principle of the ecosystem approach has been rather progressive in fisheries conventions. From the bery beginning CCAMLR had to deal with problems of over-exploited fish stock from the unregulated fishery of pre-CCAMLR times. Antarctic cod and icefish stock were already heavily harvested or even showed signs of overfishing. Conservation measures and the closure of subareas for several years did not always lead to satisfactorily results. While some stock of icefish recovered to the extent, that a new fishery on a low level could be re-opened, other icefish stocks and especially Antarctic cod stocks have not recovered from this early depletion. A new dimension in the fishery developed in the mid 1990’s, when very conservative conservation measures were introduced for the Dissostichus (toothfish), but due to the high commercial value a large illegal fishery developed rapidly in the Convention area. One additional problem of managing the longline fishery for toothfish is the by-catch and incidental mortality of sea-birds, for which special measures were established to avoid sea-bird mortality. The compliance with the measures and the elimination of the illegal fishery require strong actions of the Commission, the political decision-making body of CCAMLR. A future challange for CCAMLR could be the potentially expanding krill fishery. In the understanding of a precautionary approach, the scientific body of CCAMLR has already started to collect biological data and develop management and monitoring models for this fishery.

  13. Populações estelares do bojo galáctico

    NASA Astrophysics Data System (ADS)

    Escudero, A. V.; Costa, R. D. D.; Maciel, W. J.

    2003-08-01

    Os estudos mais recentes do bojo galáctico têm enfocado essencialmente as abundâncias químicas de elementos pesados, como o ferro, obtidos a partir das estrelas nas regiões centrais da galáxia. Elementos leves, como hélio, nitrogênio, oxigênio e argônio ainda são pouco estudados nestas regiões, devido à difícil determinação de suas abundâncias a partir de estrelas. Nestas condições as nebulosas planetárias desempenham um importante papel, pois permitem a determinação de abundâncias destes elementos usando técnicas de espectroscopia nebular. Neste trabalho, reportamos a análise das abundâncias químicas de uma nova amostra de nebulosas planetárias do bojo, bem como os resultados preliminares de um código numérico destinado a modelar a evolução química desta região. Usamos como vínculos observacionais os resultados obtidos das nebulosas planetárias, bem como de abundâncias estelares da região do bojo, obtidas da literatura. A partir deste modelo da evolução química e dos vínculos observacionais foi possível fazer um diagnóstico mais preciso das populações que constituem o bojo galáctico. O estudo destas populações que compõem a região central de nossa galáxia é de extrema importância para o maior entendimento da evolução química e dinâmica da galáxia como um todo. Por isto, verificamos a importância dos modelos de formação simples e mista utilizados para explicar características da população da região central da galáxia. Algumas destas características são: uma grande dispersão nos valores das abundâncias químicas e um grande espalhamento nas correlações entre as abundâcias de nitrogênio e oxigênio. Estas peculiaridades são dificilmente reproduzidas por modelos de formação simples, e portanto são importantes indícios da validade dos modelos de formação mista, tais como um rápido colapso do bojo seguido de uma evolução secular. (FAPESP, CNPq)

  14. Discos de acresção em sistemas Be-X

    NASA Astrophysics Data System (ADS)

    Lopes de Oliveira, R.; Janot-Pacheco, E.

    2003-08-01

    Alguns fenômenos de outbursts em Be-X sugerem a existência, mesmo que temporária, de um disco de acresção quando da passagem do objeto compacto pelo periastro orbital. Neste trabalho avaliamos a possibilidade de formação do disco de acresção em sistemas Be+estrela de neutrons e Be+anã branca, e a influência da excentricidade orbital na ocorrência deste fenômeno. Utilizamos a expressão analítica para o momento angular específico da matéria constituinte de um meio em expansão lenta, como é o caso do disco circunstelar das estrelas Be, proposta por Wang(1981), sob a condição básica de que o raio de circularização deva ser maior do que o raio de Alfvén. Concluímos que existe um limite para o período orbital do sistema acima do qual não é possível a formação do disco de acresção, e que este valor aumenta para sistemas com excentricidade orbital maior.

  15. Las propiedades de las estrellas extrañas en el marco de una nueva ecuación de estado para la materia extraña

    NASA Astrophysics Data System (ADS)

    Lugones, G.; Benvenuto, O. G.

    Se estudian las propiedades generales de las estrellas constituídas por materia extraña (ME) en el marco de una nueva ecuación de estado (EOS) en la que consideramos la masa de los quarks como dependiente del número medio de bariones por unidad de volumen. Se asume esta dependencia de forma que los quarks sean livianos (pesados) a densidades altas (bajas). En esta aproximación, la EOS de la ME es similar a la predicha por el modelo de la Bolsa del MIT, pero es significativamente mas dura a bajas densidades. Esta propiedad modifica las propiedades de las estrellas extrañas en forma notable. Encontramos que, con esta nueva EOS, los objetos pueden ser más masivos que en el caso de la EOS de la bolsa del MIT y que, además, pueden presentar mayores redshifts gravitatorios en hasta un 10%. En el caso de las oscilaciones radiales de estos objetos, calculamos la relación período vs. redshift gravitacional y encontramos una expresión analítica simple para el caso de las oscilaciones de objetos de baja masa. Encontramos que, aún con hipótesis muy diferentes en cuanto a la ecuación de estado de la materia extraña, las propiedades generales de estos objetos no se ve afectada en forma fundamental, y, por lo tanto, no deberían ser muy diferentes de las aquí expuestas.

  16. Fotometria de grupos compactos de galáxias no infravermelho próximo

    NASA Astrophysics Data System (ADS)

    Brasileiro, F.; Mendes de Oliveira, C.

    2003-08-01

    Apresentamos medidas nas bandas J, H e K de cerca de 90 galáxias em 34 grupos compactos. Através da combinação dos novos dados, com dados obtidos na literatura para a banda B, investigamos como as luminosidades, cores, tamanhos e massas das galáxias em grupos compactos foram afetadas por processos dinâmicos, e como essas diferem de galáxias em ambientes menos densos. Uma comparação dos novos valores obtidos com aqueles listados no catálogo 2MASS, mostram que para 50 galáxias estudadas em comum, as diferenças nas magnitudes J, H e K estão dentro dos erros fotométricos. Através da construção dos diagramas de cor (J-H x H-K e B-H x J-K), percebemos que as galáxias em grupos compactos ocupam posições no diagrama diferentes das posições de galáxias em campo ou em aglomerados, sendo mais parecidas com as posições ocupadas por galáxias HII, ou com excesso de poeira, acreditamos que tal deslocamento é derivado do aumento da taxa de formação estelar.

  17. Questões mais freqüentes na área de astronomia

    NASA Astrophysics Data System (ADS)

    Segundo, H. A. S.; Garcia, G. C.; Caretta, C. A.; Lima, F. P.

    2003-08-01

    É amplamente reconhecido que as pessoas em geral têm grande fascínio e interesse pela Astronomia. Por outro lado, o conteúdo dessa área incluído no ensino formal está longe de ser abrangente e suficiente para suprir a demanda. Esse interesse permite otimizar a divulgação e o ensino não formal de Astronomia aliando a adequação do conteúdo à expectativa das pessoas. Nesse intuito, nosso trabalho busca mapear que assuntos da Astronomia despertam mais a atenção e o interesse das pessoas e o quanto disso é estimulado pela mídia, que freqüentemente aproveita-se desse interesse de forma sensacionalista, trazendo contribuições positivas e negativas. Para esta avaliação, utilizamos as pesquisas específicas e de caracterização do público que freqüentou o MAst nos anos de 2001 a 2003, pesquisa das matérias de Astronomia veiculadas na mídia escrita da cidade do Rio de Janeiro no mesmo período, além da base de dados do programa Pergunte a um astrônomo, realizado no Observatório Nacional nos anos de 1997 a 1999. Para a análise dos dados, dividimos as perguntas em dez categorias, cada uma com suas subcategorias, tomando como referência as divisões, comissões e grupos de trabalho da IAU. Apresentamos neste trabalho os resultados dessa pesquisa, que incluem, entre outros, a predominância de questões nas categorias Observação do Céu e Sistemas Planetários enquanto nos jornais dominam as notícias de Sistemas Planetários e Espaço & Astronáutica. Outro resultado interessante indicou que as dúvidas de crianças do ensino fundamental se concentram em algumas categorias enquanto as questões de adultos são mais distribuídas por todas as categorias. Os resultados dessa pesquisa serão aplicados diretamente no aperfeiçoamento das atividades do Programa de Observação de Céu, bem como na elaboração de novos projetos e eventos realizados no MAst.

  18. A distribuição de velocidades na linha de visada em galáxias barradas vistas de face

    NASA Astrophysics Data System (ADS)

    Gadotti, D. A.; de Souza, R. E.

    2003-08-01

    Com o objetivo de realizar um estudo cinemático da componente vertical de barras em galáxias, obtivemos espectros de fenda longa de alta razão S/N ao longo dos eixos maior e menor de 14 galáxias barradas vistas de face, nos telescópios de 1.52m do ESO em La Silla, Chile, e de 2.3m do Steward Observatory em Kitt Peak, Arizona. Estes dados nos permitiram determinar a distribuição de velocidades das estrelas ao longo do eixo vertical das barras e discos destes sistemas, tanto no centro como em pontos que distam cerca de 5 e 20 segundos de arco do núcleo, correspondendo a distâncias de cerca de 0.7 e 2.8 kpc, respectivamente. Desta forma, a variação radial da distribuição de velocidades também pôde ser avaliada. Este tipo de análise tem raros exemplos na literatura por ser caro em termos de tempo de telescópio. Entretanto, é de fácil justificativa, considerando que traz novas informações que podem ser utilizadas para aperfeiçoar modelos teóricos acerca da formação e evolução de galáxias. Um algoritmo por nós desenvolvido foi utilizado para obter as distribuições de velocidades como Gaussianas generalizadas (polinômios de Gauss-Hermite), o que traz um ingrediente a mais neste tipo de estudo que, tradicionalmente, se utiliza de Gaussianas puras, uma hipótese nem sempre razoável. Apresentaremos os resultados deste trabalho, que incluem um diagnóstico para a identificação de barras recém formadas, e testes para o modelo isotérmico de discos. Mostraremos que: (i) a escolha das estrelas padrão em velocidade, e dos parâmetros da Gaussiana, deve ser muito bem justificada já que tem influência significativa nos resultados; (ii) muitas galáxias apresentam uma depressão na dispersão de velocidades na região central, que pode estar associada a um disco interno; e (iii) a dispersão de velocidades é constante ao longo da barra, nos eixos maior e menor, mas cai substancialmente quando se passa da barra para o disco.

  19. On Ensino da Astronomia no Ensino Médio sob Diferentes Abordagens Metodológicas

    NASA Astrophysics Data System (ADS)

    Voelzke, Marcos Rincon; Albrecht, Evonir

    2011-12-01

    O presente trabalho, sobre a intervenção de metodologias de ensino, foi desenvolvido na Escola Estadual Colônia dos Pescadores, na cidade de Caraguatatuba - SP, em três turmas do terceiro ano do Ensino Médio, perfazendo um total de 119 educandos, entre 16 e 19 anos. Antes de iniciar-se a intervenção, um questionário de vinte perguntas objetivas e dissertativas foi desenvolvido, aplicado pelo professor da classe, que ministrou as aulas correspondentes. Este questionário foi o mesmo em todas as três classes com o objetivo de diagnosticar o conhecimento prévio dos alunos sobre Astronomia. Começando a intervenção nas turmas, o professor envolvido usou três diferentes metodologias de ensino: (A) em forma de seminários, elaborados e apresentados pelos alunos, nos quais o professor fazia apenas as intervenções necessárias, (B) na forma tradicional, com a ajuda de multimídia para o desenvolvimento das aulas e a terceira (C) a tradicional, fazendo uso exclusivo de lousa e giz. No final do trabalho os alunos responderam o mesmo questionário novamente, de modo que os três métodos utilizados puderam ser comparados. Os resultados apresentados após a intervenção foram melhores que os resultados iniciais indicando a ocorrência de uma aprendizagem significativa. Quando os estudantes foram inicialmente questionados sobre quantos planetas existem no nosso sistema solar, a classe A obteve 39% de respostas certas, a classe B 48% e a classe C 46%, mas após o desenvolvimento das atividades, as classes obtiveram respectivamente 94%, 97 % e 90% de aproveitamento. No término do bimestre, foi sugerido aos educandos que elaborassem uma história em quadrinhos, a qual serviu para averiguar se os conceitos inicialmente observados foram alterados e se novos foram agregados. A análise das histórias foi dividida em três partes: Criatividade; Temas abordados; Emprego correto dos conceitos estudados. Ao final quatorze histórias foram confeccionadas. O aprendizado

  20. Off-Label and Unlicensed Drug Use in Neonatology: Reality in a Portuguese University Hospital.

    PubMed

    Silva, Joana; Flor-de-Lima, Filipa; Soares, Henrique; Guimarães, Hercília

    2015-01-01

    Introdução: Este estudo pretende caracterizar os medicamentos usados numa Unidade de Cuidados Intensivos Neonatais portuguesa, avaliar a frequência do uso de fármacos off-label ou não licenciados de acordo com a informação disponível no Resumo das Caraterísticas do Medicamento e comparar resultados entre recém-nascidos prematuros e de termo.Material e Métodos: Um estudo retrospetivo transversal foi conduzido na nossa Unidade de Cuidados Intensivos Neonatais no primeiro semestre de 2013. Os dados das prescrições realizadas foram comparados com a informação pediátrica contida nos Resumos das Caraterísticas do Medicamento.Resultados: Analisámos 1011 prescrições respeitantes a 84 substâncias ativas, feitas em 218 admissões. Em 42,9% dos casos, os fármacos foram usados de acordo com a informação do Resumo das Caraterísticas do Medicamento; 27,9% dos fármacos eram aprovados para o período neonatal mas usados de forma off-label; medicamentos off-label para a idade neonatal foram usados em 10,1%, enquanto aqueles com estado de aprovação indeterminado ou contraindicados foram usados em 6,0% e 8,7% dos casos, respetivamente. As prescrições não licenciadas representaram 4,4% do total. Os recém-nascidos pré-termo receberam uma taxa superiorde fármacos usados de acordo com o Resumo das Caraterísticas do Medicamento (p < 0,0001), enquanto os de termo receberam mais fármacos off-label para dose/frequência (p < 0,0001) e contraindicados para recém-nascidos (p < 0,012).Discussão: Os prematuros receberam um número mediano de fármacos superior, o que se relaciona com o seu internamento mais prolongado. A principal razão para prescrições off-label foi a utilização de doses/frequências de administração diferentes das referidas no Resumo das Caraterísticas do Medicamento, reforçando a necessidade de atualização destes documentos. A manipulação dosmedicamentos é uma das causas para o seu uso não licenciado, enfatizando a falta de

  1. [Congenital Anomalies Detected at Birth in Newborns of Adolescent Women].

    PubMed

    dos Reis, Leandro Valim; Araujo Júnior, Edward; Guazzelli, Cristina Aparecida Falbo; Cernach, Mirlene Cecilia Soares Pinho; Torloni, Maria Regina; Moron, Antonio Fernandes

    2015-01-01

    Introdução: Analisar a prevalência das anomalias congénitas, detetadas no nascimento, entre filhos de gestantes adolescentes, enfatizando os tipos mais comuns e a época do diagnóstico. Material e Métodos: Estudo retrospetivo do tipo censo, no qual foram analisados todos recém-nascidos, vivos ou mortos, com peso superior a 500 g, de mulheres que tiveram o parto no Hospital São Paulo num período de seis anos. Os produtos da conceção portadores de anomalias foram identificados no período pré-natal ou através do exame físico pós-natal, segundo os critérios do Estudo Colaborativo Latino-Americano das Malformações Congênitas. Os resultados são apresentados de forma descritiva através de valores absolutos e relativos, calcula-se a prevalência das anomalias e comparam-se os diferentes grupos recorrendo a testes não paramétricos. Resultados: Foram analisadas 6 257 gestações, das quais 577 resultaram em recém-nascidos com alguma anomalia congénita identificada no nascimento (prevalência de 9,2%). Do total de gestações, 907 eram de adolescentes (idade inferior a 20 anos), para as quais se verificou uma prevalência de anomalias nos recém-nascidos de 9,9%. Comparando os recém-nascidos de adolescentes com os das mulheres com idade superior a 20 anos, apenas se encontrou diferença estatisticamente significativa para a prevalência dos defeitos do tubo neural (p = 0,027). Discussão: Observamos uma alta taxa de partos em adolescentes, acima das taxas dos países desenvolvidos. Observamos também alta frequência de anomalias congénitas em recém-nascidos, provavelmente por sermos um serviço terciário de referência. A elevada prevalência dos defeitos do tubo neural entre grávidas jovens pode ser explicada pela não suplementação pré-concecional de ácido fólico em gravidezes não planeadas, como é característico nas adolescentes.Conclusão: A prevalência e momento do diagnóstico das anomalias congénitas em rec

  2. Gradiente radial de [Mg/Fe] em duas galáxias elípticas

    NASA Astrophysics Data System (ADS)

    Milone, A.; Capelato, H.

    2003-08-01

    Basicamente, são propostos dois cenários de evolução quí mio-dinâmico para os sistemas esferoidais: (i) o hierárquico através da fusão e/ou acresção de sub-sistemas com ou sem surtos de formação estelar, e (ii) o colapso monolí tico dissipativo com formação estelar interrompida por um vento galáctico. Ambos, dentro de certos limites, conseguem explicar os gradientes internos de metalicidade estelar presentes nas galáxias elí pticas bem como a relação observada entre a metalicidade central e a massa (Mg20 vs. log sv0). No entanto, nenhum prevê uma variação interna para a razão de abundâncias Mg/Fe que indiretamente define a escala temporal da formação estelar. Empregamos a espectroscopia óptica de fenda longa com a finalidade de recuperar as histórias de formação estelar, de enriquecimento quí mico e da dinâmica dentro de determinadas regiões das galáxias. Os espectros de média resolução (FWHM = 7,1 Å) e escala angular de 1,092 arcsec/pixel foram coletados com o telescópio 1,60m do OPD/LNA. Comparamos nossas medidas de linhas de absorção com resultados espectrofotométricos de modelos de populações estelares simples - mais especificamente os í ndices do Sistema Lick como Mg2, Mg b, < Fe > e Hb - a fim de se investigar as variações internas de [Fe/H], [Mg/Fe] e idade. Para duas galáxias elí pticas, NGC 1052 e NGC 7796, pertencentes a ambientes de baixa densidade, encontramos uma variação radial da razão Mg/Fe decrescente do centro para fora em regiões de 0,6 e 1 raio efetivo respectivamente. Discutimos alguns cenários de enriquecimento quí mico para estas duas galáxias.

  3. [Energy expenditure prediction equations in burn patients; bibliographic review].

    PubMed

    Núñez-Villaveirán, Teresa; Sánchez, Manuel; Millán, Pablo; Martínez-Méndez, Jose Ramón; Iglesias, Carmen; Casado-Pérez, César; García-de-Lorenzo, Abelardo

    2014-06-01

    Introducción: La valoración de las necesidades calóricas del paciente quemado se ha basado en la medición del gasto energético en reposo (GER) mediante calorimetría indirecta, no siempre disponible en las unidades de quemados, o en su estimación mediante el uso de ecuaciones predictivas. Objetivos: analizar la historia y estado del arte del uso de las ecuaciones predictivas de GER en el paciente quemado crítico, y determinar su validez. Métodos: revisión bibliográfica de estudios y revisiones en español y en inglés entre 1989 y 2013. Resultados: Se han diseñado más de 190 ecuaciones para estimar el gasto energético que pueden ser imprecisas por estar basadas en mediciones con metodología heterogénea y en grupos heterogéneos. Describimos los distintos parámetros que aplican las distintas fórmulas predictivas (factores de estrés y de actividad, superficie corporal quemada, tiempo desde la lesión, masa corporal magra), la influencia de la edad en el cálculo de las necesidades calóricas y las fórmulas más utilizadas en el momento actual. También describimos los artículos que evalúan exactitud de las fórmulas cuando se comparan con mediciones mediante calorimetría indirecta. Conclusiones: Las ecuaciones predictivas son poco precisas en general en el paciente quemado. Hasta que se desarrollen ecuaciones predictivas más precisas, recomendamos calcular los requerimientos nutricionales de los pacientes quemados basándose en la medición del gasto energético por calorimetría indirecta.

  4. Augmentation mastopexy after bariatric surgery: evaluation of patient satisfaction and surgical results.

    PubMed

    Junior, Wilson Cintra; Modolin, Miguel Luiz Antonio; Rocha, Rodrigo Itocazo; Gemperli, Rolf

    2016-01-01

    : forma da mama, volume da mama, simetria entre as mamas, posicionamento do complexo aréolo-papilar e qualidade e extensão das cicatrizes. dezenove pacientes (95%) referiram satisfação com o resultado cirúrgico obtido (p<0,001). A média das somatórias das notas atribuídas pelos três cirurgiões, referentes a cada paciente, variou entre 4,7 e 10, sendo a média geral de 7,28. Os resultados foram considerados bons ou ótimos para 65% da amostra e pobres para 8,4%. houve satisfação de 95% das pacientes com os resultados obtidos pela mastopexia de aumento. A análise fotográfica dos resultados obteve nota média de 7,28, caracterizado como bom resultado, apesar da fraca concordância entre os avaliadores.

  5. Física e Arte nas Estações do Ano

    NASA Astrophysics Data System (ADS)

    Pessôa Queiroz, Glória; da Conceição Barbosa Lima, Maria; Navarro Vasconcellos das Mercês, Maria

    2004-12-01

    The paper deals with the subject of the Four Seasons, exploring elements of Science and the Art in order to motivate students or public of museums of science and technology to understand it from their current cultural experiences and of old times. Physics joins to Astronomy to explain the phenomenon, while the use of Music and Painting make possible the immersion in the subject in way to many trips to the imagination capable to awake emotions.A proposal didactic is presented and justified for some consensus of the research in the area of teaching-learning of science, since that related to the persistent alternative conceptions concerning the causes of the changes observed at the different times of the year until the qualitative modelling of phenomena that appeals three-dimensional pedagogical models. Such proposal was developed in the activity named " Hiper interesting Talk: The Four Seasons, Science and Art" in the first Sunday of August/2003 in the Museum of Astronomy, MAST. O artigo trata do tema das Estações do Ano, explorando elementos da Ciência e da Arte como forma de motivar estudantes ou público de museus de ciência e tecnologia a compreendê-lo a partir de vivências culturais atuais e de outras épocas. A Física se junta à Astronomia para explicar o fenômeno, enquanto a Música e a Pintura possibilitam a imersão no tema em meio a muitas viagens à imaginação capazes de despertar emoções.Uma proposta didática é apresentada e justificada por consensos das muitas pesquisas na área de ensino-aprendizagem de ciências, desde os que se referem às persistentes concepções alternativas acerca das causas das mudanças observadas nas diferentes épocas do ano até à modelagem qualitativa de fenômenos que recorre a modelos pedagógicos tridimensionais. Tal proposta foi desenvolvida na atividade "Bate papo Hiperinteressante: As Quatro Estações, Ciência e Arte" realizada no primeiro domingo do mês de agosto de 2003 no Museu de Astronomia.

  6. Health technology assessment (HTA) organizations: dimensions of the institutional and political framework.

    PubMed

    Novaes, Hillegonda Maria Dutilh; Soárez, Patrícia Coelho de

    2016-11-03

    Health technology assessment (HTA) is consolidated as a scientific and technological practice. The aim of this study is to identify HTA organizations from different settings and analyze their relevant dimensions in terms of effectiveness/impact, in order to address the challenges they face in Brazil. Narrative literature review based on data and websites of HTA organizations. There are well-established activity development processes in all organizations. These activities have specific features in their profile, in the process of technology assessment, decision and implementation of technologies that influence their potential impact on health systems. Agencies share in common the challenges of ranking the technologies to be assessed, and the implementation of their recommendations. Technical and political strengthening of the institutionalization of HTA in Brazil may foster scientific, technological and innovation policies, effectively impacting health policies. Resumo: A avaliação de tecnologias em saúde (ATS) está consolidada enquanto prática científica e tecnológica. O objetivo do estudo é identificar organizações de ATS de diferentes contextos e analisá-las de acordo com dimensões relevantes na avaliação de sua efetividade/impacto, buscando contribuir com os desafios enfrentados no contexto nacional. Revisão narrativa da literatura, realizada em bases de dados e web sites de organizações de ATS. Existem processos de desenvolvimento das atividades bem estabelecidos em todas as organizações. Elas apresentam particularidades no seu perfil, nos processos de avaliação, decisão e implementação das tecnologias que influenciam o seu impacto potencial sobre os sistemas de saúde. As agências compartilham os desafios de priorização das tecnologias a serem avaliadas e implementação das suas recomendações. O fortalecimento técnico e político do processo de institucionalização da ATS no contexto nacional poderá contribuir com as pol

  7. [Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: genotype-phenotype correlation].

    PubMed

    Mendes, Catarina; Vaz Matos, Inês; Ribeiro, Luís; Oliveira, Maria João; Cardoso, Helena; Borges, Teresa

    2015-01-01

    Introdução: A hiperplasia congénita da suprarrenal por deficiência de 21-hidroxílase constitui uma das doenças hereditárias mais comuns. Resulta de diferentes mutações no gene CYP21A2 e, na maioria dos casos, a gravidade da doença correlaciona-se com a variação alélica do CYP21A2. O objetivo deste estudo foi descrever o espectro mutacional do CYP21A2 e avaliar a correlação genótipo-fenótipo numa coorte de doentes portugueses com deficiência de 21-hidroxílase. Material e Métodos: Estudo retrospetivo de 22 doentes com diagnóstico clínico de deficiência de 21-hidroxílase. Foi feita análise molecular do CYP21A2 e estabelecida a correlação genótipo-fenótipo. Resultados: Foi realizada genotipagem em 22 doentes não relacionados: 5 com a forma clássica perdedora de sal (idade média ao diagnóstico de 10,2 dias; mínimo 1, máximo 20 dias), 7 com a forma clássica virilizante simples (idade média ao diagnóstico de 3,5 anos; mínimo 0 dias, máximo 7 anos) e 10 com a forma não clássica (idade média ao diagnóstico de 5,7 anos; mínimo 4 anos, máximo 8 anos). Os defeitos genéticos mais frequentes nas formas clássicas foram o I2 splice (24%) e I172N (24%), seguindo-se o Q318X (16%) e deleções de genes (16%) e, na forma não clássica, o V281L (80%). Verificou-se uma concordância genótipo-fenótipo global de 81,8%. O genótipo permitiu prever adequadamente o fenótipo em 83,3%, 100% e 90% dos doentes com mutações compatíveis com a forma clássica perdedora de sal, clássica virilizante simples e não clássica, respectivamente. Discussão: A frequência de defeitos genéticos observados nos nossos doentes é comparável a estudos semelhantes. Observou-se, na maioria dos casos, uma boa correlação genótipo-fenótipo. Conclusões: A análise molecular do CYP21A2 fornece informação importante relativamente à gravidade da doença e no aconselhamento genético e pré-natal.

  8. Effectiveness of prediction equations in estimating energy expenditure sample of Brazilian and Spanish women with excess body weight.

    PubMed

    Lopes Rosado, Eliane; Santiago de Brito, Roberta; Bressan, Josefina; Martínez Hernández, José Alfredo

    2014-03-01

    Objetivo: Evaluar la adecuación de las ecuaciones de predicción para la estimación del gasto energético (GE), en comparación con el GE medido por calorimetría indirecta en una muestra de mujeres brasileñas y españolas con exceso de peso corporal. Métodos: Se trata de un estudio transversal con 92 mujeres adultas obesas [26 brasileñas —G1— y 66 españolas —G2— (20-50 años)]. Se evaluó el peso y la talla durante el ayuno para el cálculo del índice de masa corporal y las ecuaciones de predicción. Se evaluó el GE usando la calorimetría indirecta de circuito abierto con campana respiratoria. Resultados: En G1 y G2, se encontró que las estimaciones obtenidas por Harris-Benedict, Shofield, FAO/OMS/ ONU y Henry y Rees no difieren del GE estimado por calorimetría indirecta, la cual presentó valores más altos que las ecuaciones propuestas por Owen Mifflin -St Jeor y Oxford. Para G1 y G2 la ecuación predictiva que presentó valores más cercanos al valor obtenido por la calorimetría indirecta fue la FAO/OMS/ONU (7,9% y 0,46% subestimación, respectivamente), seguido por Harris-Benedict (8,6% y 1,5% subestimación, respectivamente). Conclusión: Las ecuaciones propuestas por la FAO/ OMS/ONU, Harris-Benedict, Shofield y Henry & Rees fueron adecuadas para estimar el GE en una muestra de mujeres brasileñas y españolas con exceso de peso corporal. Las otras ecuaciones subestimaron el GE.

  9. Datação do disco galáctico pela nucleocosmocronologia do [Th/Eu

    NASA Astrophysics Data System (ADS)

    del Peloso, E. F.; da Silva, L.; Arany-Prado, L. I.

    2003-08-01

    A nucleocosmocronologia emprega abundâncias de nuclídeos radioativos na datação de escalas de tempo astrofísicas. O 232Th é um nuclídeo radioativo com meia-vida de 14 Gano, enquanto que os dois isótopos mais abundantes do Eu são estáveis. O decaimento radioativo do Th modifica as razões de abundâncias [Th/Eu], fornecendo assim um meio de sondar a escala de formação das populações estelares. O objetivo deste trabalho é averiguar a possibilidade de estimar uma idade para o disco Galáctico através da nucleocosmocronologia do [Th/Eu] e investigar o nível de incerteza associado a esta estimativa. Para tanto, foi selecionada uma amostra de 20 estrelas anãs ou subgigantes de tipos espectrais F5 a G9, com -1,00 £ [Fe/H] £ +0,30 e idade(Gano) £ 13. As abundâncias de Th e Eu foram obtidas por síntese espectral das linhas localizadas em 4019,1 Å e 4129,7 Å, respectivamente. Uma comparação destas abundâncias com outros resultados da literatura demonstra que nossos valores apresentam dispersão 2 a 3 vezes menor que qualquer trabalho anterior. Os parâmetros atmosféricos e abundâncias dos elementos que contaminam as regiões espectrais destas linhas foram determinados por nós, de maneira totalmente autoconsistente, através de análise espectral detalhada diferencial em relação ao Sol. As idades estelares individuais foram determinadas através de curvas isócronas teóricas no diagrama HR. Foi realizada, então, uma análise cronológica dos gráficos [Th/Eu] vs. [Fe/H] e [Th/Eu] vs. idade. Os dados estelares foram comparados a curvas calculadas para 3 idades do disco Galáctico - 9, 12, 15 Gano - e foi estudada a sensibilidade à idade assumida no cálculo do ajuste destas curvas aos dados. Estas curvas foram calculadas com base num modelo analítico de evolução química da Galáxia que leva em consideração a formação de refugos, que são compostos pelos remanescentes da evolução estelar, pelos resíduos da formação de estrelas de

  10. Autobiographies: A Way to Explore Student-Teachers' Beliefs in a Teacher Education Program (Autobiografías: una forma de explorar las creencias de docentes en formación en un programa de Licenciatura en Inglés)

    ERIC Educational Resources Information Center

    Durán Narváez, Norma Constanza; Lastra Ramírez, Sandra Patricia; Morales Vasco, Adriana María

    2013-01-01

    Autobiographies depict with words life stories, personal experiences, and perceptions that allow researchers to deeply understand the way people see life, reflect, and construct meaning out of experiences. This article aims at describing the contributions of autobiographies as valuable resources in qualitative research when exploring people's…

  11. Skype™ Conference Calls: A Way to Promote Speaking Skills in the Teaching and Learning of English (Llamadas para conferencia en Skype™: una forma de promover la habilidad de habla en la enseñanza y aprendizaje del inglés)

    ERIC Educational Resources Information Center

    Romaña Correa, Yeferson

    2015-01-01

    This article presents the results of a research project on the teaching and learning of English through the use of Skype™ conference calls. The research was carried out with a group of 12 English as a foreign language adult learners in the language institute of Universidad Distrital Francisco José de Caldas, Bogotá, Colombia. The findings of this…

  12. Teaching English through Stories: A Meaningful and Fun Way for Children to Learn the Language (La enseñanza del inglés a través de historias: una forma divertida y significativa para que los niños aprendan el idioma)

    ERIC Educational Resources Information Center

    Porras González, Nohora Inés

    2010-01-01

    This article presents the results of a study on utilizing stories for teaching English as a foreign language to children in first, second and third grades. It was carried out in a Colombian public elementary school in Bucaramanga, Colombia. The proposal was initiated by a group of student-teachers at Universidad Cooperativa de Colombia, Seccional…

  13. ...And That's How It All Began: Putting Information about Your Child's Growth, Health and Safety All within Your Reach...Because the First Years Last Forever! = ...Y asi es como empezo todo: Ponemos a su alcance en forma conjunta la informacion sobre el crecimiento, la salud y la seguridad de su hijo...Porque los primeros anos duran para siempre!

    ERIC Educational Resources Information Center

    North Carolina Partnership for Children, Raleigh.

    Smart Start is North Carolina's model early childhood initiative to help all North Carolina children enter school healthy and prepared for success. This resource guide, in Spanish and English versions, is designed to provide parents with information on infant and child development, health care, and resources for further assistance. Presented in an…

  14. ...And That's How It All Began: Putting Information about Your Child's Growth, Health and Safety All within Your Reach...Because the First Years Last Forever! = ...Y asi es como empezo todo: Ponemos a su alcance en forma conjunta la informacion sobre el crecimiento, la salud y la seguridad de su hijo...Porque los primeros anos duran para siempre!

    ERIC Educational Resources Information Center

    North Carolina Partnership for Children, Raleigh.

    Smart Start is North Carolina's model early childhood initiative to help all North Carolina children enter school healthy and prepared for success. This resource guide, in Spanish and English versions, is designed to provide parents with information on infant and child development, health care, and resources for further assistance. Presented in an…

  15. Detecção inesperada de efeitos de lentes fracas em grupos de galáxias pouco luminosos em raios-X

    NASA Astrophysics Data System (ADS)

    Carrasco, R.; Mendes de Oliveira, C.; Sodrã©, L., Jr.; Lima Neto, G. B.; Cypriano, E. S.; Lengruber, L. L.; Cuevas, H.; Ramirez, A.

    2003-08-01

    Obtivemos, como parte do programa de verificação científica do GMOS Sul, imagens profundas de três grupos de galáxias: G97 e G102 (z~0,4) e G124 (z = 0,17). Esses alvos foram selecionados a partir do catálogo de fontes extensas de Vikhlinin (1998), por terem luminosidades em raios X menores que 3´1043 ergs s-1, valor cerca de uma ou duas ordens de grandeza inferior ao de aglomerados de galáxias. O objetivo primário dessas observações é o estudo da evolução de galáxias em grupos. Grupos são ambientes menos densos que aglomerados, contêm a grande maioria das galáxias do Universo mas que, até o momento, foram estudados detalhadamente apenas no Universo local (z~0). Com esses dados efetuamos uma análise estatística da distorção na forma das galáxias de fundo (lentes gravitacionais fracas) como forma de inferir o conteúdo e a distribuição de massa nesses grupos apesar de que, em princípio, esse efeito não deveria ser detectado uma vez que os critérios de seleção adotados previlegiam sistemas de baixa massa. De fato, para G124 obtivemos apenas um limite superior para sua massa que é compatível com sua luminosidade em raios X. De modo contrário e surpreendente, os objetos G102 e G097, aparentam ter massas que resultariam em dispersões de velocidade maiores que 1000 km s-1, muito maiores do que se espera para grupos de galáxias. Com efeito, para G097 obtivemos, a partir de dados do satélite XMM, uma estimativa para a temperatura do gás intragrupo de kT = 2,6 keV, que é tipica de sistemas com dispersões de velocidade de ~ 600 km s-1, bem característica de grupos. Essas contradições aparentes entre lentes fracas e raios X podem ser explicadas de dois modos: i) a massa obtida por lentes estaria sobreestimada devido à superposição de estruturas massivas ao longo da linha de visada ou ii) a temperatura do gás do meio intra-grupo reflete o potencial gravitacional de estruturas menores que estariam se fundindo para formar uma

  16. A preliminary inventory of the catfishes of the lower Rio Nhamundá, Brazil (Ostariophysi, Siluriformes).

    PubMed

    Collins, Rupert A; Duarte Ribeiro, Emanuell; Nogueira Machado, Valéria; Hrbek, Tomas; Farias, Izeni Pires

    2015-01-01

    The Rio Nhamundá is a poorly-known clearwater river draining the southern Guiana Shield of Brazil. In this study we report the findings of a preliminary ichthyological survey, focusing on catfishes (Siluriformes). We identify a total of 36 species (31 genera, seven families) from the Nhamundá, including 11 species already recorded from the river. Overall, our survey results show that even rapid surveys can provide important information on Amazon fish biodiversity, suggesting potential new species, providing range extensions for nominal species, and additionally highlighting taxa in need of taxonomic revision and genetic study. As well as the traditional forms of data collected on biodiversity surveys (i.e. preserved specimen vouchers), our study also provides "new" types of data in the form of DNA barcodes and images of fishes exhibiting colouration in life, information that will be invaluable in future work addressing difficult groups. O Rio Nhamundá é um rio de água clara, pouco conhecido, que drena parte do Escudo das Guianas em território brasileiro. Nesse estudo, nós reportamos os resultados de um levantamento ictiofaunístico preliminar dessa área, tendo como foco os bagres (Siluriformes). Nós identificamos um total de 36 espécies (31 gêneros, sete famílias) provenientes de nossa coleta, e adicionamos 11 espécies já conhecidas para o rio. De maneira geral, os resultados de nossa pesquisa mostram que mesmo levantamentos rápidos podem gerar informações importantes sobre a biodiversidade de peixes amazônicos, sugerindo potenciais espécies novas, ampliando a área de distribuição de espécies, além de apontar a necessidade de revisões taxonômicas e estudos genéticos para alguns taxa. Para além das formas tradicionais de dados coletados em pesquisas de biodiversidade (i.e. espécimes preservados), nosso estudo fornece "novas" formas de dados, como DNA barcodes e imagens com o padrão de coloração dos espécimes vivos, informa

  17. A preliminary inventory of the catfishes of the lower Rio Nhamundá, Brazil (Ostariophysi, Siluriformes)

    PubMed Central

    Duarte Ribeiro, Emanuell; Nogueira Machado, Valéria; Hrbek, Tomas; Farias, Izeni Pires

    2015-01-01

    Abstract The Rio Nhamundá is a poorly-known clearwater river draining the southern Guiana Shield of Brazil. In this study we report the findings of a preliminary ichthyological survey, focusing on catfishes (Siluriformes). We identify a total of 36 species (31 genera, seven families) from the Nhamundá, including 11 species already recorded from the river. Overall, our survey results show that even rapid surveys can provide important information on Amazon fish biodiversity, suggesting potential new species, providing range extensions for nominal species, and additionally highlighting taxa in need of taxonomic revision and genetic study. As well as the traditional forms of data collected on biodiversity surveys (i.e. preserved specimen vouchers), our study also provides "new" types of data in the form of DNA barcodes and images of fishes exhibiting colouration in life, information that will be invaluable in future work addressing difficult groups. O Rio Nhamundá é um rio de água clara, pouco conhecido, que drena parte do Escudo das Guianas em território brasileiro. Nesse estudo, nós reportamos os resultados de um levantamento ictiofaunístico preliminar dessa área, tendo como foco os bagres (Siluriformes). Nós identificamos um total de 36 espécies (31 gêneros, sete famílias) provenientes de nossa coleta, e adicionamos 11 espécies já conhecidas para o rio. De maneira geral, os resultados de nossa pesquisa mostram que mesmo levantamentos rápidos podem gerar informações importantes sobre a biodiversidade de peixes amazônicos, sugerindo potenciais espécies novas, ampliando a área de distribuição de espécies, além de apontar a necessidade de revisões taxonômicas e estudos genéticos para alguns taxa. Para além das formas tradicionais de dados coletados em pesquisas de biodiversidade (i.e. espécimes preservados), nosso estudo fornece "novas" formas de dados, como DNA barcodes e imagens com o padrão de coloração dos espécimes vivos, informa

  18. Diferentes metodologias aplicadas ao ensino de astronomia no Ensino Médio

    NASA Astrophysics Data System (ADS)

    Albrecht, E.; Voelzke, M. R.

    2009-03-01

    O presente trabalho de intervenção foi realizado junto à Escola Estadual Colònia dos Pescadores na cidade de Caraguatatuba, com très turmas do terceiro ano do Ensino Médio, envolvendo 119 alunos com idades entre 16 e 19 anos. A fase inicial foi composta de um questionário de vinte questíes dissertativas e objetivas, aplicado pelo professor titular da sala, que era o mesmo nas très turmas, para diagnosticar nos educandos os conceitos prévios sobre Astronomia e, partindo destes realizar um trabalho de intervenção nas classes envolvidas utilizando, em cada uma, metodologias diferentes: (A) sob forma de seminários, elaborados e apresentados pelos educandos, no qual o educador faz apenas as intervençíes necessárias; (B) de forma tradicional, com auxílio de multimídias para desenvolvimento das aulas e a terceira (C) tradicional, fazendo uso exclusivo de lousa e giz. Ao final do trabalho os alunos responderam novamente o questionário inicial para diagnosticar dentre as très metodologias utilizadas qual apresentou melhores aplicaçíes, os resultados iniciais foram comparados com os finais. Quando questionados a respeito do significado de Astronomia observou-se inicialmente que os acertos na turma A foram de 100%, turma B: 64%, turma C: 84%, após a intervenção os acertos foram: 100%, 97% e 85% respectivamente, demonstrando que houve um avanço significativo na turma B, a turma A manteve seu índice e a turma C evoluiu, porém não tanto quanto a B. Quando interrogados sobre quantos planetas vocè acha que existem em nosso Sistema Solar? os acertos foram: turma A: 39%, turma B: 48% e turma C: 46%, após o desenvolvimento do trabalho os acertos foram 94%, 97% e 90% respectivamente. Dentro das respostas obtidas observa-se que a metodologia tradicional com o auxílio de multimeios, aplicada na turma B, demonstrou melhores resultados, sendo a mais significativa. Outra conclusão muito importante é que apesar de o tema Astronomia ser amplamente

  19. Ensino de Astronomia no Ensino Médio

    NASA Astrophysics Data System (ADS)

    Albrecht, E.; Voelzke, M. R.

    2008-09-01

    O presente trabalho de intervenção foi realizado junto a Escola Estadual Colônia dos Pescadores na cidade de Caraguatatuba, com três turmas do terceiro ano do Ensino Médio, envolvendo 119 alunos, 40 na turma A, 40 na turma B e 39 na turma C. A fase inicial foi composta de um questionário de vinte questões dissertativas e objetivas para diagnosticar nos educandos os conceitos prévios sobre Astronomia e, partindo destes realizar uma interferência nas classes envolvidas utilizando metodologias diferentes sendo elas: a tradicional, onde o professor é um repassador de informações, fazendo uso exclusivo de lousa e giz; a segunda também de forma tradicional, porém com auxílio de multimídia para desenvolvimento das aulas e a terceira sob forma de seminários, elaborados e apresentados pelos educandos, no qual o educador faz apenas as intervenções necessárias. Ao final do trabalho as mesmas turmas da fase inicial orientadas pelo mesmo professor responderam novamente ao questionário proposto para diagnosticar dentre as três metodologias utilizadas qual apresentou melhores resultados, sendo os iniciais comparados com os finais. Quando questionados a respeito do significado de Astronomia observou-se inicialmente que os acertos na turma A foram de 100%,turma B: 64%, turma C: 84%, após a intervenção os acertos foram: 100%, 97% e 85% respectivamente, demonstrando claramente uma absorção de conhecimentos. Quando interrogados sobre quantos planetas você acha que existem em nosso Sistema Solar? os acertos foram: turma A: 39%, turma B: 48% e turma C: 46%, após o desenvolvimento do trabalho os acertos foram 94%, 97% e 90% respectivamente.Dentro das respostas obtidas observa-se que a metodologia tradicional com o auxílio de multimeios, aplicada na turma B, demonstrou melhores resultados, foi a mais significativa.

  20. [Etiopathogenesis and treatment of breast capsular contracture].

    PubMed

    Pereira Leite, Luis; Correia Sá, Inês; Marques, Marisa

    2013-01-01

    Introdução: A contractura capsular é a complicação crónica mais frequente da mamoplastia de aumento com próteses mamárias e a principal causa de insatisfação da doente e do cirurgião plástico. A cápsula mamária consiste num tecido fibroso que circunda a prótese e que pode contrair, alterando a forma e a consistência da mama. No estádio mais avançado é acompanhada de deformidade acentuada, rigidez e dor, tendo indicação para tratamento cirúrgico.Material e Métodos: Foram revistos todos os artigos indexados na PubMed através da pesquisa ‘capsular contracture’ (2000 - Janeiro 2012), dos quais foram inseridos os artigos de maior interesse em termos de etiologia, profilaxia e tratamento. Artigos referenciados em publicações relevantes foram também analisados.Resultados: Tudo indica que a sua etiologia é multifactorial; a etiopatogenia da contractura capsular mamária continua a ser alvo de múltipla investigação pré-clínica. Vários são os estudos realizados de forma a prevenir a ocorrência de contractura capsular e, embora os resultados sejam promissores, pouco está definido em termos da sua aplicação na prática clínica. Relativamente ao tratamento a capsulectomia/capsulotomia continua a ser o gold-standard, no entanto o futuro poderá passar por técnicas não invasivas, pelo menos em estádios mais leves da doença.Conclusão: Apesar das técnicas cirúrgicas e a qualidade das próteses mamárias terem vindo a melhorar drasticamente nos últimos anos, a contractura capsular mamária mantém-se uma complicação real, com incidência elevada e que continua a afectar milhares de mulheres no mundo.