78 FR 46322 - Endangered and Threatened Species; 90-Day Finding on Petition To Delist the Southern Oregon...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-31

..., August 15, 2011). As part of each review, we fully considered the effects of ocean productivity on coho... ocean productivity was considered, including consideration of Mantua et al., 1997. We published our... adverse effects of natural environmental variability caused by drought, flooding and ocean productivity...

The effect of days since last concussion and number of concussions on cognitive functioning in Division I athletes.

PubMed

Thoma, Robert J; Cook, Julia A; McGrew, Christopher; King, John H; Mayer, Andrew R; Lewine, Jeffrey D; Yeo, Ronald A; Campbell, Richard

2015-01-01

Cognitive recovery from sports concussion may be incomplete after resolution of other symptoms. It was hypothesized that independent effects of the number of days since last concussion (Days) and total number of concussions (Number) would predict poorer cognitive functioning. Cognition was assessed in an NCAA Division I student-athlete population (n = 87) using the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) battery. In a MANOVA, the five ImPACT Composite scores were dependent variables, with Group (Concussion, Unaffected) as the independent variable and prior number of concussions (Number) and days since last concussion (Days; 68-2495 days) entered as covariates. The hypothesis that Days and Number would each independently affect cognitive functioning (as assessed by ImPACT Composite scores) was only partly supported. A significant, multivariate, main effect of Days (p = 0.01) indicated that more Days predicted better cognitive functioning overall (p = 0.01). Univariate effects emerged such that more Days specifically predicted better visual memory (p = 0.004) and faster reaction times (p = 0.02). A trend toward a Group*Days*Number three-way interaction for reaction time emerged (p = 0.06), such that smaller Number and more Days each predicted slower reaction time. Cognitive recovery following sports concussion may take far longer than was previously thought, the aetiology of cognitive reductions may be very complex and the ImPACT appears to be sensitive to subtle changes in cognition across time.

Variability and reliability study of overall physical activity and activity intensity levels using 24 h-accelerometry-assessed data.

PubMed

Jaeschke, Lina; Steinbrecher, Astrid; Jeran, Stephanie; Konigorski, Stefan; Pischon, Tobias

2018-04-20

24 h-accelerometry is now used to objectively assess physical activity (PA) in many observational studies like the German National Cohort; however, PA variability, observational time needed to estimate habitual PA, and reliability are unclear. We assessed 24 h-PA of 50 participants using triaxial accelerometers (ActiGraph GT3X+) over 2 weeks. Variability of overall PA and different PA intensities (time in inactivity and in low intensity, moderate, vigorous, and very vigorous PA) between days of assessment or days of the week was quantified using linear mixed-effects and random effects models. We calculated the required number of days to estimate PA, and calculated PA reliability using intraclass correlation coefficients. Between- and within-person variance accounted for 34.4-45.5% and 54.5-65.6%, respectively, of total variance in overall PA and PA intensities over the 2 weeks. Overall PA and times in low intensity, moderate, and vigorous PA decreased slightly over the first 3 days of assessment. Overall PA (p = 0.03), time in inactivity (p = 0.003), in low intensity PA (p = 0.001), in moderate PA (p = 0.02), and in vigorous PA (p = 0.04) slightly differed between days of the week, being highest on Wednesday and Friday and lowest on Sunday and Monday, with apparent differences between Saturday and Sunday. In nested random models, the day of the week accounted for < 19% of total variance in the PA parameters. On average, the required number of days to estimate habitual PA was around 1 week, being 7 for overall PA and ranging from 6 to 9 for the PA intensities. Week-to-week reliability was good (intraclass correlation coefficients, range, 0.68-0.82). Individual PA, as assessed using 24 h-accelerometry, is highly variable between days, but the day of assessment or the day of the week explain only small parts of this variance. Our data indicate that 1 week of assessment is necessary for reliable estimation of habitual PA.

Variation in children’s classroom engagement throughout a day in preschool: Relations to classroom and child factors

PubMed Central

Vitiello, Virginia E.; Booren, Leslie M.; Downer, Jason T.; Williford, Amanda

2014-01-01

This study examined sources of variability in preschool children’s positive and negative engagement with teachers, peers, and tasks, and how that variability was related to both classroom activity settings (e.g., teacher-structured time, outdoor time, transitions) and child factors (age, gender). Participants were 283 socioeconomically and linguistically diverse children drawn from 84 classrooms, 34 to 63 months old (M = 50.8, SD = 6.5). Each child’s engagement was observed and rated multiple times within a single day. Results suggested that children’s engagement varied significantly across the preschool day. Activity settings that provided children with a greater degree of choice (free choice and outdoor time) were associated with more positive engagement with peers and tasks, while teacher-structured activities were associated with more positive engagement with teachers. Transitions emerged as a difficult part of the day, associated with less positive engagement with teachers and tasks. Older children were rated higher on peer and task engagement. These findings, together with previous research, suggest that both characteristics of the classroom setting and child factors are associated with children’s classroom engagement throughout a day in preschool. PMID:25717218

VizieR Online Data Catalog: Photometric observations of PMS objects (Fernandez, 1995)

NASA Astrophysics Data System (ADS)

Fernandez, M.

1995-05-01

We present the observational data of a photometric monitoring of 24 pre-main sequence objects: T Tauri stars, Ae/Be Herbig stars and some unclassified objects. Observations were carried out from July 1988 to August 1992, using the UBV(RI)_c system. Variability with time scales from days to years and amplitudes in the V band larger than 0.1 mag is found for a part of this sample. The analysis of the possible causes of this variability are discussed in separate papers (Fernandez & Eiroa 1995a,b). (24 data files).

Forgotten Children: A Program for the Multihandicapped.

ERIC Educational Resources Information Center

Frampton, Merle E.; And Others

In a cerebral palsy-blind experimental school unit for day and residential care, a staff of 13 served 30 children in 6 years with 12 to 17 children each year. All but six children who were found to be nontrainable progressed: eight became trainable, eight trainable and partly educable, and eight educable. Variable progress was found characteristic…

Accidents in the greenhouse-construction industry of SE Spain.

PubMed

Pérez-Alonso, José; Carreño-Ortega, Angel; Vázquez-Cabrera, Fernando J; Callejón-Ferre, Angel Jesús

2012-01-01

This work analyses the labour accidents in the greenhouse-construction industry of SE Spain for the period 1999-2007 through a sample of 180 accident reports. The accidents were characterised by studying 5 variables in order to know the day of the week in which the accident occurred, the hour of the day of the accident, type of accident, the region of Spain in which the accident happened, and the resulting injury. The data characterising the accidents were submitted to a descriptive multiple-correspondence analysis. The incidence of accidents in the greenhouse-construction industry presented a high mean value of 15133.7 per 100,000 workers per year. The days with the greatest incidence of accidents were Thursday and Monday, while the period of greatest number of accidents occurred in the first 4h of the workday. No significant correspondence was found between the day of the week, the hour of the day, or any of the other 3 variables studied. The types of accidents with most frequency were: cuts, punctures, contact with hard or rough material, overexertion, and falls from one level to another. The most affected parts of the anatomy were the eyes, thorax, back, sides, lower legs, and feet. The most common types of injury were bone fractures, twists and sprains, distended muscles, contusions, and being crushed. The study calls attention to the high number of accidents at work, which needs to be corrected by fulfilment of safety regulations at work, on the part of the company. Finally, recommendations are made to correct this situation of high number of accidents at work. Copyright © 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Investigation of the Short-Time Variability of Tropical Tropospheric Ozone

NASA Technical Reports Server (NTRS)

Randriambelo, Tantely; Baray, Jean-Luc; Baldy, Serge; Thompson, Anne M.; Oltmans, Samuel; Keckhut, Philippe

2003-01-01

Since 1998, a ground based tropospheric ozone lidar has been running at Reunion Island and has been involved with a daily measurement campaign that was performed in the latter part of the biomass burning season, during November-December 1999. The averaged ozone profile obtained during November-December 1 999 agrees well with averaged ozone profile obtained from ozonesondes launch at Reunion during November-December (1992- 2001). Comparing weekly sonde launches (part of the Southern Hemisphere Additional Ozonesondes: SHADOZ program) with the daily ground-based lidar observations shows that some striking features of the day to day variability profiles are not observed in the sonde measurements. Ozone profiles respond to the nature of disturbances which vary from the one day to the next. The vertical ozone distribution at Reunion is examined as a function of prevailing atmospheric circulation. Backtrajectories show that most of the enhanced ozone crossed over biomass burning and convectively active regions in Madagascar and the southern African continent. The analyses of the meteorological data show that ozone stratification profiles are in agreement with the movement of the synoptical situations in November-December 1999. Three different sequences of transport are explained using wind fields. The first sequence from 23 to 25 November is characterized by Northerly transport, the second sequence from 26 to 30 November, the air masses are influenced by meridional transport. The third sequence from 2 to 6 December is characterized by westerly transport associated with the subtropical jet stream. The large standard deviations of lidar profiles in the middle and upper troposphere are in agreement with the upper wind variabilities which evidence passing ridge and trough disturbances. During the transition period between the dry season and the wet season, multiple ozone sources including stratosphere-troposphere exchanges, convection and biomass burning contribute to tropospheric ozone at Reunion Island through sporadic events characterized by a large spatial and temporal variability.

Indoor noise exposure at home: a field study in the family of urban schoolchildren.

PubMed

Pujol, S; Berthillier, M; Defrance, J; Lardies, J; Levain, J-P; Petit, R; Houot, H; Mauny, F

2014-10-01

This article aims at evaluating indoor noise levels at home and investigating the factors that may influence their variability. An 8-day noise measurement campaign was conducted in the homes of 44 schoolchildren attending the public primary schools of Besançon (France). The presence of the inhabitants in the dwelling and the noisy events occurring indoors and outdoors was daily collected using a time-location-activity diary (TLAD); 902 time periods were analyzed. The indoor noise level increased significantly with the outdoor noise level, along with the duration of the presence or level of activity of the inhabitants at home. However, this effect may vary according to the period of day and the day of the week. Moreover, a significant part of the day and evening indoor noise level variability was explained when considering the TLAD variables: 46% and 45% in the bedroom, 54% and 39% in the main room, respectively. Our results highlight the complexity of the indoor environment in the dwellings of children living in an urban area. Combining the inhabitant presence and indoor noise source descriptors with outdoor noise levels and other dwelling or inhabitant characteristics could improve large-scale epidemiological studies. However, additional efforts are still needed, particularly during the night period. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Towards multi-resolution global climate modeling with ECHAM6-FESOM. Part II: climate variability

NASA Astrophysics Data System (ADS)

Rackow, T.; Goessling, H. F.; Jung, T.; Sidorenko, D.; Semmler, T.; Barbi, D.; Handorf, D.

2018-04-01

This study forms part II of two papers describing ECHAM6-FESOM, a newly established global climate model with a unique multi-resolution sea ice-ocean component. While part I deals with the model description and the mean climate state, here we examine the internal climate variability of the model under constant present-day (1990) conditions. We (1) assess the internal variations in the model in terms of objective variability performance indices, (2) analyze variations in global mean surface temperature and put them in context to variations in the observed record, with particular emphasis on the recent warming slowdown, (3) analyze and validate the most common atmospheric and oceanic variability patterns, (4) diagnose the potential predictability of various climate indices, and (5) put the multi-resolution approach to the test by comparing two setups that differ only in oceanic resolution in the equatorial belt, where one ocean mesh keeps the coarse 1° resolution applied in the adjacent open-ocean regions and the other mesh is gradually refined to 0.25°. Objective variability performance indices show that, in the considered setups, ECHAM6-FESOM performs overall favourably compared to five well-established climate models. Internal variations of the global mean surface temperature in the model are consistent with observed fluctuations and suggest that the recent warming slowdown can be explained as a once-in-one-hundred-years event caused by internal climate variability; periods of strong cooling in the model (`hiatus' analogs) are mainly associated with ENSO-related variability and to a lesser degree also to PDO shifts, with the AMO playing a minor role. Common atmospheric and oceanic variability patterns are simulated largely consistent with their real counterparts. Typical deficits also found in other models at similar resolutions remain, in particular too weak non-seasonal variability of SSTs over large parts of the ocean and episodic periods of almost absent deep-water formation in the Labrador Sea, resulting in overestimated North Atlantic SST variability. Concerning the influence of locally (isotropically) increased resolution, the ENSO pattern and index statistics improve significantly with higher resolution around the equator, illustrating the potential of the novel unstructured-mesh method for global climate modeling.

Predictors of Nightly Subjective-Objective Sleep Discrepancy in Poor Sleepers over a Seven-Day Period

PubMed Central

Herbert, Vanessa; Pratt, Daniel; Emsley, Richard; Kyle, Simon D.

2017-01-01

This study sought to examine predictors of subjective/objective sleep discrepancy in poor sleepers. Forty-two individuals with insomnia symptoms (mean age = 36.2 years, 81% female) were recruited to take part in a prospective study which combined seven days of actigraphy with daily assessment of sleep perceptions, self-reported arousal, sleep effort, and mood upon awakening. A high level of intra-individual variability in measures of sleep discrepancy was observed. Multilevel modelling revealed that higher levels of pre-sleep cognitive activity and lower mood upon awakening were significantly and independently predictive of the underestimation of total sleep time. Greater levels of sleep effort predicted overestimation of sleep onset latency. These results indicate that psychophysiological variables are related to subjective/objective sleep discrepancy and may be important therapeutic targets in the management of insomnia. PMID:28282912

Modeling the hydrologic effects of land and water development interventions: a case study of the upper Blue Nile river basin

NASA Astrophysics Data System (ADS)

Haregeweyn, Nigussie; Tsunekawa, Atsushi; Tsubo, Mitsuru; Meshesha, Derege; Adgo, Enyew; Poesen, Jean; Schütt, Brigitta

2014-05-01

Over 67% of the Ethiopian landmass has been identified as very vulnerable to climate variability and land degradation. These problems are more prevalent in the Upper Blue Nile (UBN, often called Abay) river basin covering a drainage area of about 199,800 km2. The UBN River runs from Lake Tana (NW Ethiopia) to the Ethiopia-Sudan border. To enhance the adaptive capacity to the high climate variability and land degradation in the basin, different land and water management measures (stone/soil bunds, runoff collector trenches, exclosures) have been extensively implemented, especially since recent years. Moreover, multipurpose water harvesting schemes including the Grand Ethiopian Renaissance Dam (GERD, reservoir area of ca. 4000 km2) and 17 other similar projects are being or to be implemented by 2025. However, impact studies on land and water management aspects rarely include detailed hydrological components especially at river basin scale, although it is generally regarded as a major determinant of hydrological processes. The main aim of this study is therefore to model the significance of land and water management interventions in surface runoff response at scale of UBN river basin and to suggest some recommendations. Spatially-distributed annual surface runoff was simulated for both present-day and future (2025) land and water management conditions using calibrated values of the proportional loss model in ArcGIS environment. Average annual rainfall map (1998-2012) was produced from calibrated TRMM satellite source and shows high spatial variability of rainfall ranging between ca. 1000 mm in the Eastern part of the basin to ca. 2000 mm in the southern part of the basin. Present-day land use day condition was obtained from Abay Basin Master Plan study. The future land use map was created taking into account the land and water development interventions to be implemented by 2025. Under present-day conditions, high spatial variability of annual runoff depth was observed in the basin ranging from 80 mm in the central part of the basin to over 1700 mm in water bodies. This variation is mainly controlled by variation in surface conditions and areal-extent of each land use type, and rainfall depth. For a specific land use type, runoff depth is found to increase with elevation as this in turn directly influences the rainfall distribution. By 2025, due to the land and water management interventions, total runoff depth in the basin could decrease by up to 40%. Following the conversion of other land use types to water bodies due to the medium to large-scale water harvesting schemes such as GERD reservoir, runoff response in those specific parts of the basin could increase by over 200%. Sub-basins have been prioritized for future land and water management interventions. Further study remains necessary to understand the downstream impacts of those interventions on runoff and sediment discharges. Keywords: Land and water management; Upper Blue Nile; Grand Ethiopian Renaissance Dam; Spatial variability of runoff; Downstream impact.

Impact of motor fluctuations on real-life gait in Parkinson's patients.

PubMed

Silva de Lima, Ana Lígia; Evers, Luc J W; Hahn, Tim; de Vries, Nienke M; Daeschler, Margaret; Boroojerdi, Babak; Terricabras, Dolors; Little, Max A; Bloem, Bastiaan R; Faber, Marjan J

2018-05-01

People with PD (PWP) have an increased risk of becoming inactive. Wearable sensors can provide insights into daily physical activity and walking patterns. (1) Is the severity of motor fluctuations associated with sensor-derived average daily walking quantity? (2) Is the severity of motor fluctuations associated with the amount of change in sensor-derived walking quantity after levodopa intake? 304 Dutch PWP from the Parkinson@Home study were included. At baseline, all participants received a clinical examination. During the follow-up period (median: 97 days; 25-Interquartile range-IQR: 91 days, 75-IQR: 188 days), participants used the Fox Wearable Companion app and streamed smartwatch accelerometer data to a cloud platform. The first research question was assessed by linear regression on the sensor-derived mean time spent walking/day with the severity of fluctuations (MDS-UPDRS item 4.4) as independent variable, controlled for age and MDS-UPDRS part-III score. The second research question was assessed by linear regression on the sensor-derived mean post-levodopa walking quantity, with the sensor-derived mean pre-levodopa walking quantity and severity of fluctuations as independent variables, controlled for mean time spent walking per day, age and MDS-UPDRS part-III score. PWP spent most time walking between 8am and 1pm, summing up to 72 ± 39 (mean ± standard deviation) minutes of walking/day. The severity of motor fluctuations did not influence the mean time spent walking (B = 2.4 ± 1.9, p = 0.20), but higher age (B = -1.3 ± 0.3, p = < 0.001) and greater severity of motor symptoms (B = -0.6 ± 0.2, p < 0.001) was associated with less time spent walking (F(3216) = 14.6, p < .001, R 2  = .17). The severity of fluctuations was not associated with the amount of change in time spent walking in relation to levodopa intake in any part of the day. Analysis of sensor-derived gait quantity suggests that the severity of motor fluctuations is not associated with changes in real-life walking patterns in mildly to moderate affected PWP. Copyright © 2018 Elsevier B.V. All rights reserved.

DETERMINING THE INFLUENCE OF LANDSCAPE AND RESEARCH-SPECIFIC HABITAT VARIABLES ON VARIATION OF THERMAL CHARACTERISTICS OF STREAMS WITHIN WESTERN LAKE SUPERIOR WATERSHEDS

EPA Science Inventory

As part of a study to develop and test a framework for predicting sensitivity of watersheds to land-use activities, temperatures were monitored in 48 second- and third- order streams on the north and south shores of western Lake Superior. Maximun 21-day average temperatures, whic...

Comparison of Two Stochastic Daily Rainfall Models and their Ability to Preserve Multi-year Rainfall Variability

NASA Astrophysics Data System (ADS)

Kamal Chowdhury, AFM; Lockart, Natalie; Willgoose, Garry; Kuczera, George; Kiem, Anthony; Parana Manage, Nadeeka

2016-04-01

Stochastic simulation of rainfall is often required in the simulation of streamflow and reservoir levels for water security assessment. As reservoir water levels generally vary on monthly to multi-year timescales, it is important that these rainfall series accurately simulate the multi-year variability. However, the underestimation of multi-year variability is a well-known issue in daily rainfall simulation. Focusing on this issue, we developed a hierarchical Markov Chain (MC) model in a traditional two-part MC-Gamma Distribution modelling structure, but with a new parameterization technique. We used two parameters of first-order MC process (transition probabilities of wet-to-wet and dry-to-dry days) to simulate the wet and dry days, and two parameters of Gamma distribution (mean and standard deviation of wet day rainfall) to simulate wet day rainfall depths. We found that use of deterministic Gamma parameter values results in underestimation of multi-year variability of rainfall depths. Therefore, we calculated the Gamma parameters for each month of each year from the observed data. Then, for each month, we fitted a multi-variate normal distribution to the calculated Gamma parameter values. In the model, we stochastically sampled these two Gamma parameters from the multi-variate normal distribution for each month of each year and used them to generate rainfall depth in wet days using the Gamma distribution. In another study, Mehrotra and Sharma (2007) proposed a semi-parametric Markov model. They also used a first-order MC process for rainfall occurrence simulation. But, the MC parameters were modified by using an additional factor to incorporate the multi-year variability. Generally, the additional factor is analytically derived from the rainfall over a pre-specified past periods (e.g. last 30, 180, or 360 days). They used a non-parametric kernel density process to simulate the wet day rainfall depths. In this study, we have compared the performance of our hierarchical MC model with the semi-parametric model in preserving rainfall variability in daily, monthly, and multi-year scales. To calibrate the parameters of both models and assess their ability to preserve observed statistics, we have used ground based data from 15 raingauge stations around Australia, which consist a wide range of climate zones including coastal, monsoonal, and arid climate characteristics. In preliminary results, both models show comparative performances in preserving the multi-year variability of rainfall depth and occurrence. However, the semi-parametric model shows a tendency of overestimating the mean rainfall depth, while our model shows a tendency of overestimating the number of wet days. We will discuss further the relative merits of the both models for hydrology simulation in the presentation.

Individual differences in the day-to-day variability of pain, fatigue, and well-being in patients with rheumatic disease: Associations with psychological variables

PubMed Central

Schneider, Stefan; Junghaenel, Doerte U.; Keefe, Francis J.; Schwartz, Joseph E.; Stone, Arthur A.; Broderick, Joan E.

2012-01-01

This paper examines day-to-day variability in rheumatology patients' ratings of pain and related quality-of-life variables as well as predictors of that variability. Data from two studies were used. The hypothesis was that greater psychological distress (i.e., depression and anxiety) and poorer coping appraisals (i.e., higher pain catastrophizing and lower self-efficacy) are associated with more variability. Electronic daily diary ratings were collected from 106 patients from a community rheumatology practice across 28 days (Study 1), and from 194 osteoarthritis patients across 7 days (Study 2). In multilevel modeling analyses, substantial day-to-day variability was evident for all variables in both studies, andindividual patients differed considerably and somewhat reliably in the magnitude of their variability. Higher levels of depression significantly predicted greater variability in pain, as well as in happiness and frustration (Study 1). Lower self-efficacy was associated with more variability in patients' daily satisfaction with accomplishments and in the quality of their day (Study 2). Greater pain catastrophizing and higher depression predicted more variability in interference with social relationships (Study 2). Anxiety was not significantly associated with day-to-day variability. The results of these studies suggest that individual differences in the magnitude of symptom fluctuation may play a vital role in understanding patients' adjustment to pain. Future research will be needed to examine the clinical utility of measuring variability in patients' pain and well being, and to understand whether reducing variability may be an important treatment target. PMID:22349917

High stimulus variability in nonnative speech learning supports formation of abstract categories: evidence from Japanese geminates.

PubMed

Sadakata, Makiko; McQueen, James M

2013-08-01

This study reports effects of a high-variability training procedure on nonnative learning of a Japanese geminate-singleton fricative contrast. Thirty native speakers of Dutch took part in a 5-day training procedure in which they identified geminate and singleton variants of the Japanese fricative /s/. Participants were trained with either many repetitions of a limited set of words recorded by a single speaker (low-variability training) or with fewer repetitions of a more variable set of words recorded by multiple speakers (high-variability training). Both types of training enhanced identification of speech but not of nonspeech materials, indicating that learning was domain specific. High-variability training led to superior performance in identification but not in discrimination tests, and supported better generalization of learning as shown by transfer from the trained fricatives to the identification of untrained stops and affricates. Variability thus helps nonnative listeners to form abstract categories rather than to enhance early acoustic analysis.

Dynamic Sensorimotor Planning during Long-Term Sequence Learning: The Role of Variability, Response Chunking and Planning Errors

PubMed Central

Verstynen, Timothy; Phillips, Jeff; Braun, Emily; Workman, Brett; Schunn, Christian; Schneider, Walter

2012-01-01

Many everyday skills are learned by binding otherwise independent actions into a unified sequence of responses across days or weeks of practice. Here we looked at how the dynamics of action planning and response binding change across such long timescales. Subjects (N = 23) were trained on a bimanual version of the serial reaction time task (32-item sequence) for two weeks (10 days total). Response times and accuracy both showed improvement with time, but appeared to be learned at different rates. Changes in response speed across training were associated with dynamic changes in response time variability, with faster learners expanding their variability during the early training days and then contracting response variability late in training. Using a novel measure of response chunking, we found that individual responses became temporally correlated across trials and asymptoted to set sizes of approximately 7 bound responses at the end of the first week of training. Finally, we used a state-space model of the response planning process to look at how predictive (i.e., response anticipation) and error-corrective (i.e., post-error slowing) processes correlated with learning rates for speed, accuracy and chunking. This analysis yielded non-monotonic association patterns between the state-space model parameters and learning rates, suggesting that different parts of the response planning process are relevant at different stages of long-term learning. These findings highlight the dynamic modulation of response speed, variability, accuracy and chunking as multiple movements become bound together into a larger set of responses during sequence learning. PMID:23056630

How East Asian westerly jet's meridional position affects the summer rainfall in Yangtze-Huaihe River Valley?

NASA Astrophysics Data System (ADS)

Wang, Shixin; Zuo, Hongchao; Zhao, Shuman; Zhang, Jiankai; Lu, Sha

2017-03-01

Existing studies show that the change in the meridional position of East Asian westerly jet (EAWJ) is associated with rainfall anomalies in Yangtze-Huaihe River Valley (YHRV) in summer. However, the dynamic mechanism has not been resolved yet. The present study reveals underlying mechanisms for this impact for early summer and midsummer, separately. Mechanism1: associated with EAWJ's anomalously southward displacement, the 500-hPa westerly wind over YHRV is strengthened through midtropospheric horizontal circulation anomalies; the westerly anomalies are related to the formation of warm advection anomalies over YHRV, which cause increased rainfall through adiabatic ascent motion and convective activities; the major difference in these processes between early summer and midsummer is the midtropospheric circulation anomaly pattern. Mechanism 2: associated with EAWJ's anomalously southward displacement, the large day-to-day variability of midtropospheric temperature advection in midlatitudes is displaced southward by the jet's trapping transient eddies; this change enhances the day-to-day variability of temperature advection over YHRV, which in turn causes the increased rainfall in most part of YHRV through "lower-bound effect" (rainfall amount can not become negative); there is not much difference in these processes between early summer and midsummer.

Acute Psychosis after Recent Isoniazid Initiation

PubMed Central

Sukhija, Gagandeep; Singh, Harpreet

2015-01-01

Isoniazid as part of Directly Observed Treatment-Short course (DOTS) regimen is universally used. Although, associated psychosis in certain cases is documented earlier, type of symptoms and onset of symptoms remains highly variable. We describe a case of 54-year-old female on anti-tubercular therapy with onset of psychosis within three days of Isoniazid initiation characterised by agitation, loosening of association, echolalia with spontaneous remission after drug stoppage. This case highlights the importance of remaining vigilant and considering isoniazid as possible causative agent for psychosis even within days of its intiation and avoiding delay in management. PMID:26266198

A preliminary investigation of daily variability of stuttering in adults.

PubMed

Constantino, Christopher D; Leslie, Paula; Quesal, Robert W; Yaruss, J Scott

2016-01-01

Variability in frequency of stuttering has made the results of treatment outcome studies difficult to interpret. Many factors that affect variability have been investigated; yet the typical range of variability experienced by speakers remains unknown. This study examined the day-to-day variability in the percentage of syllables containing stuttered and nonstuttered disfluencies in the speech of six adult speakers in three spontaneous speaking situations and two reading tasks. The frequency of moments stuttering during the tasks were compared within and between speakers and days to document the degree of variability in stuttering frequency and explore whether there were any consistent patterns. The Stuttering Severity Instrument-Fourth Edition (SSI-4) and Overall Assessment of the Speaker's Experience of Stuttering for Adults (OASES-A) were also tested for day-to-day variability. Correlations between frequency, severity, and life impact were made. The primary result of this study was the large range over which frequency of stuttering varied from day to day for the same individual. This variability did not correlate with any measures of stuttering severity but did correlate with life impact as measured by the OASES-A. No global pattern was detected in variability from day to day within or between participants. However, there were significantly more nonstuttered disfluencies present during the spontaneous speaking tasks than during the reading tasks. The day-to-day variability in the life impact of the disorder (OASES-A) was less than the day-to-day variability in observable stuttering behavior (percentage of syllables stuttered and SSI-4). Frequency of stuttering varies significantly from situation to situation and day to day, with observed variability exceeding the degree of change often reported in treatment outcomes studies from before to after treatment. This variability must be accounted for in future clinical and scientific work. Copyright © 2016 Elsevier Inc. All rights reserved.

Spatiotemporal Variability and in Snow Phenology over Eurasian Continent druing 1966-2012

NASA Astrophysics Data System (ADS)

Zhong, X.; Zhang, T.; Wang, K.; Zheng, L.; Wang, H.

2016-12-01

Snow cover is a key part of the cryosphere, which is a critical component of the global climate system. Snow cover phenology critically effects on the surface energy budget, the surface albedo and hydrological processes. In this study, the climatology and spatiotemporal variability of snow cover phenology were investigated using the long-term (1966-2012) ground-based measurements of daily snow depth from 1103 stations across the Eurasian Continent. The results showed that the distributions of the first date, last date, snow cover duration and number of snow cover days generally represented the latitudinal zonality over the Eurasian Continent, and there were significant elevation gradient patterns in the Tibetan Plateau. The first date of snow cover delayed by about 1.2 day decade-1, the last date of snow cover advanced with the rate of -1.2 day decade-1, snow cover duration and number of snow cover days shortened by about 2.7and 0.6 day decade-1, respectively, from 1966 through 2012. Compared with precipitation, the correlation between snow cover phenology and air temperature was more significant. The changes in snow cover duration were mainly controlled by the changes of air temperature in autumn and spring. The shortened number of snow cover days was affected by rising temperature during the cold season except for the air temperature in autumn and spring.

Population nutrikinetics of green tea extract.

PubMed

Scholl, Catharina; Lepper, Anna; Lehr, Thorsten; Hanke, Nina; Schneider, Katharina Luise; Brockmöller, Jürgen; Seufferlein, Thomas; Stingl, Julia Carolin

2018-01-01

Green tea polyphenols may contribute to the prevention of cancer and other diseases. To learn more about the pharmacokinetics and interindividual variation of green tea polyphenols after oral intake in humans we performed a population nutrikinetic study of standardized green tea extract. 84 healthy participants took green tea extract capsules standardized to 150 mg epigallocatechin-gallate (EGCG) twice a day for 5 days. On day 5 catechin plasma concentrations were analyzed using non-compartmental and population pharmacokinetic methods. A strong between-subject variability in catechin pharmacokinetics was found with maximum plasma concentrations varying more than 6-fold. The AUCs of EGCG, EGC and ECG were 877.9 (360.8-1576.5), 35.1 (8.0-87.4), and 183.6 (55.5-364.6) h*μg/L respectively, and the elimination half lives were 2.6 (1.8-3.8), 3.9 (0.9-10.7) and 1.8 (0.8-2.9) h, respectively. Genetic polymorphisms in genes of the drug transporters MRP2 and OATP1B1 could at least partly explain the high variability in pharmacokinetic parameters. The observed variability in catechin plasma levels might contribute to interindividual variation in benefical and adverse effects of green tea polyphenols. Our data could help to gain a better understanding of the causes of variability of green tea effects and to improve the design of studies on the effects of green tea polyphenols in different health conditions. ClinicalTrials.gov: NCT01360320.

Intraseasonal patterns in coastal plankton biomass off central Chile derived from satellite observations and a biochemical model

NASA Astrophysics Data System (ADS)

Gomez, Fabian A.; Spitz, Yvette H.; Batchelder, Harold P.; Correa-Ramirez, Marco A.

2017-10-01

Subseasonal (5-130 days) environmental variability can strongly affect plankton dynamics, but is often overlooked in marine ecology studies. We documented the main subseasonal patterns of plankton biomass in the coastal upwelling system off central Chile, the southern part of the Humboldt System. Subseasonal variability was extracted from temporal patterns in satellite data of wind stress, sea surface temperature, and chlorophyll from the period 2003-2011, and from a realistically forced eddy-resolving physical-biochemical model from 2003 to 2008. Although most of the wind variability occurs at submonthly frequencies (< 30 days), we found that the dominant subseasonal pattern of phytoplankton biomass is within the intraseasonal band (30-90 days). The strongest intraseasonal coupling between wind and plankton is in spring-summer, when increased solar radiation enhances the phytoplankton response to upwelling. Biochemical model outputs show intraseasonal shifts in plankton community structure, mainly associated with the large fluctuations in diatom biomass. Diatom biomass peaks near surface during strong upwelling, whereas small phytoplankton biomass peaks at subsurface depths during relaxation or downwelling periods. Strong intraseasonally forced changes in biomass and species composition could strongly impact trophodynamics connections in the ecosystem, including the recruitment of commercially important fish species such as common sardine and anchovy. The wind-driven variability of chlorophyll concentration was connected to mid- and high-latitude atmospheric anomalies, which resemble disturbances with frequencies similar to the tropical Madden-Julian Oscillation.

The Schaake shuffle: A method for reconstructing space-time variability in forecasted precipitation and temperature fields

USGS Publications Warehouse

Clark, M.R.; Gangopadhyay, S.; Hay, L.; Rajagopalan, B.; Wilby, R.

2004-01-01

A number of statistical methods that are used to provide local-scale ensemble forecasts of precipitation and temperature do not contain realistic spatial covariability between neighboring stations or realistic temporal persistence for subsequent forecast lead times. To demonstrate this point, output from a global-scale numerical weather prediction model is used in a stepwise multiple linear regression approach to downscale precipitation and temperature to individual stations located in and around four study basins in the United States. Output from the forecast model is downscaled for lead times up to 14 days. Residuals in the regression equation are modeled stochastically to provide 100 ensemble forecasts. The precipitation and temperature ensembles from this approach have a poor representation of the spatial variability and temporal persistence. The spatial correlations for downscaled output are considerably lower than observed spatial correlations at short forecast lead times (e.g., less than 5 days) when there is high accuracy in the forecasts. At longer forecast lead times, the downscaled spatial correlations are close to zero. Similarly, the observed temporal persistence is only partly present at short forecast lead times. A method is presented for reordering the ensemble output in order to recover the space-time variability in precipitation and temperature fields. In this approach, the ensemble members for a given forecast day are ranked and matched with the rank of precipitation and temperature data from days randomly selected from similar dates in the historical record. The ensembles are then reordered to correspond to the original order of the selection of historical data. Using this approach, the observed intersite correlations, intervariable correlations, and the observed temporal persistence are almost entirely recovered. This reordering methodology also has applications for recovering the space-time variability in modeled streamflow. ?? 2004 American Meteorological Society.

Dietary patterns among children aged 6-7 y in four Spanish cities with widely differing cardiovascular mortality.

PubMed

Rodríguez-Artalejo, F; Garcés, C; Gorgojo, L; López García, E; Martín-Moreno, J M; Benavente, M; del Barrio, J L; Rubio, R; Ortega, H; Fernández, O; de Oya, M

2002-02-01

Classic cardiovascular risk factors, such as smoking, arterial hypertension and hypercholesterolaemia, cannot explain a substantial part of the geographic differences in cardiovascular mortality. Anthropometric and nutritional factors in early stages of life may contribute to adult cardiovascular disease. Therefore, this work examines certain anthropometric variables and diet among children aged 6-7 y, living in four Spanish cities with widely differing ischaemic heart disease (IHD) mortality. Cross-sectional anthropometric and dietary survey in four cities in Spain. A total of 1112 children (50.1% males, 49.9% females) attending public and private schools in Cadiz and Murcia, cities with a relatively high IHD mortality, and Madrid and Orense, cities with a relatively low IHD mortality. A standardized method was used to measure anthropometric variables, and a food-frequency questionnaire completed by subjects' mothers, to measure diet. Body mass index (BMI), overweight (BMI>17.6 kg/m(2)), obesity (BMI>20.1 kg/m(2)) and intake of food and nutrients. Children in the four cities showed a high prevalence of overweight (range across cities, 28.9-34.5%) and obesity (8.5-15.7%). They also had a moderately hypercaloric diet (range, 2078-2218 kcal/day), marked by an excessive intake of lipids (45.0-47.3% kcal), particularly saturated fats (16.6-16.9% kcal), proteins (17.0-17.3% kcal), sugars (20.0-21.9% kcal) and cholesterol (161.6-182.9 mg/1000 kcal/day), and a low intake of complex carbohydrates (17.5-18.1% kcal) and fibre (19.6-19.9 g/day). Compared with children in the two low-IHD-mortality cities, those in the two high-IHD-mortality cities had a greater BMI (mean difference, 0.61 kg/m(2); P=0.0001) and ponderal index (0.58 kg/m(3); P=0.0001) and a higher intake of energy (104 kcal/day; P=0.007), cholesterol (16.00 mg/1000 kcal/day; P=0.0001) and sodium (321 mg/day; P=0.0001). Inter-city differences in anthropometric variables remained after adjustment for birthweight. Intake of fats, especially saturated fats, and cholesterol should be reduced among Spanish children. It could contribute to a needed reduction of the high prevalence of overweight and obesity in children. If the differences in anthropometric variables and diet between children from the cities with high and low coronary mortality are maintained in future or continue into adulthood, this could contribute to consolidate or even increase the IHD mortality gradient across cities. The finding that differences in anthropometric variables are independent of birthweight suggests that the childhood, rather than intrauterine environment, is involved in the development of such differences. This study was partly funded by grants from the International Olive Oil Board (Consejo Oleícola Internacional), Comunidad Autónoma de Madrid, Fundación Pedro Barrié de la Maza, and Fundación Eugenio Rodríguez Pascual.

Intraseasonal variability of upper-ocean currents and photosynthetic primary production along the U.S. west coast associated with the Madden-Julian Oscillation

NASA Astrophysics Data System (ADS)

Barrett, B.; Davies, A. R.; Steppe, C. N.; Hackbarth, C.

2017-12-01

In the first part of this study, time-lagged composites of upper-ocean currents from February to May of 1993-2016 were binned by active phase of the leading atmospheric mode of intraseasonal variability, the Madden-Julian Oscillation (MJO). Seven days after the convectively active phase of the MJO enters the tropical Indian Ocean, anomalously strong south-southeastward upper-ocean currents are observed along the majority of U.S. west coast. Seven days after the convectively active phase enters the tropical western Pacific Ocean, upper-ocean current anomalies reverse along the U.S. west coast, with weaker southward flow. A physical pathway to the ocean was found for both of these: (a) tropical MJO convection modulates upper-tropospheric heights and circulation over the Pacific Ocean; (b) those anomalous atmospheric heights adjust the strength and position of the Aleutian Low and Hawaiian High; (c) surface winds change in response to the adjusted atmospheric pressure patterns; and (d) those surface winds project onto upper-ocean currents. In the second part of this study, we investigated if the MJO modulated intraseasonal variability of surface wind forcing and upper-ocean currents projected onto phytoplankton abundance along the U.S. west coast. Following a similar methodology, time-lagged, level 3 chlorophyll-a satellite products (a proxy for photosynthetic primary production) were binned by active MJO phase and analyzed for statistical significance using the Student's t test. Results suggest that intraseasonal variability of biological production along the U.S. west coast may be linked to the MJO, particularly since the time scale of the life cycle of phytoplankton is similar to the time scale of the MJO.

Aortic arch atherosclerosis in patients with severe aortic stenosis can be argued by greater day-by-day blood pressure variability.

PubMed

Iwata, Shinichi; Sugioka, Kenichi; Fujita, Suwako; Ito, Asahiro; Matsumura, Yoshiki; Hanatani, Akihisa; Takagi, Masahiko; Di Tullio, Marco R; Homma, Shunichi; Yoshiyama, Minoru

2015-07-01

Although it is well known that the prevalence of aortic arch plaques, one of the risk factors for ischemic stroke, is high in patients with severe aortic stenosis, the underlying mechanisms are not well understood. Increased day-by-day blood pressure (BP) variability is also known to be associated with stroke; however, little is known on the association between day-by-bay BP variability and aortic arch atherosclerosis in patients with aortic stenosis. Our objective was to clarify the association between day-by-day BP variables (average values and variability) and aortic arch atherosclerosis in patients with severe aortic stenosis. The study population consisted of 104 consecutive patients (mean age 75 ± 8 years) with severe aortic stenosis who were scheduled for aortic valve replacement. BP was measured in the morning in at least 4 consecutive days (mean 6.8 days) prior to the day of surgery. Large (≥4 mm), ulcerated, or mobile plaques were defined as complex plaques using transesophageal echocardiography. Cigarette smoking and all systolic BP variables were associated with the presence of complex plaques (p < 0.05), whereas diastolic BP variables were not. Multiple regression analysis indicated that day-by-day mean systolic BP and day-by-day systolic BP variability remained independently associated with the presence of complex plaques (p < 0.05) after adjustment for age, male sex, cigarette smoking, hypertension, hypercholesterolemia, and diabetes mellitus. These findings suggest that higher day-by-day mean systolic BP and day-by-day systolic BP variability are associated with complex plaques in the aortic arch and consequently stroke risk in patients with aortic stenosis. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Active metabolite concentration of clopidogrel in patients taking different doses of aspirin: results of the interaction trial.

PubMed

Liang, Y; Hirsh, J; Weitz, J I; Sloane, D; Gao, P; Pare, G; Zhu, J; Eikelboom, J W

2015-03-01

The CURRENT-OASIS-7 and PLATO trials suggest that the benefit of clopidogrel is influenced by the dose of aspirin. To explore a potential pharmacokinetic interaction between aspirin and clopidogrel, and determinants of clopidogrel active metabolite (AM) levels. In part 1, using a 2 × 2 factorial design, we randomized patients to clopidogrel 600 mg loading dose (LD) followed by 150 mg day(-1) for 6 days and 75 mg day(-1) thereafter, or clopidogrel 300 mg LD followed by 75 mg day(-1) thereafter, and compared aspirin at 325 mg or 81 mg day(-1) . In part 2, patients were given a 600-mg clopidogrel LD, and were randomly allocated to aspirin 325 mg or 81 mg day(-1) . We combine the data from the two parts. Blood samples were collected 1 h after administration of the study drug. We randomized 302 patients (mean age 60.4 ± 9.9 years). Clopidogrel AM levels were similar in patients randomized to aspirin 325 or 81 mg (geometric mean, 12.70 ng mL(-1) ; 95% CI, 10.96-14.72 ng mL(-1) ; and geometric mean, 12.55 ng mL(-1) ; 95% CI, 10.80-14.58 ng mL(-1) ; P = 0.91). Blood levels of clopidogrel were lower in CYP2C19*2 loss-of-function (LOF) carriers compared with non-carriers (10.72 ng mL(-1) ; 95% CI, 8.83-13.01 ng mL(-1) ; and 15.21 ng mL(-1) ; 95% CI, 13.30-17.40 ng mL(-1) , respectively; P = 0.003) whereas levels in gain of function carriers and non-carriers were similar (13.31 ng mL(-1) ; 95% CI, 11.53-15.35 ng mL(-1) ; and 14.07 ng mL(-1) ; 95% CI, 11.74-16.87 ng mL(-1) , respectively; P = 0.4). Independent baseline predictors of clopidogrel AM levels were LOF genotype, body mass index, diabetes, proton pump inhibitor use and creatinine clearance, but accounted for only 20% of the variability in levels. Aspirin dose does not predict clopidogrel AM levels 1 h post-LD. Most of the variability in clopidogrel AM levels is not explained by patient characteristics or CYP2C19 metabolizer status. © 2014 International Society on Thrombosis and Haemostasis.

Day-to-Day Variability in Self-Reported Cigarettes Per Day.

PubMed

Hughes, John R; Shiffman, Saul; Naud, Shelly; Peters, Erica N

2017-09-01

Nicotine addiction theory predicts small day-to-day variability in cigarettes/day (CPD) whereas social learning theory predicts large variability. A description of the variability in CPD over multiple days is not available. We conducted secondary analyses of two natural history studies with daily smokers-one of smokers not intending to quit, and one of smokers intending to quit sometime in the next 3 months. In the former, smokers recorded their smoking during the day by Ecological Momentary Assessment, using a palm-top computer. In the latter, participants reported CPD nightly via a phone Interactive Voice Response system. Analyses were based on smokers who reported averaging ≥10 CPD, and on days in which there was no attempt to stop or reduce smoking. Across the two studies, on average, smokers had small changes in day-to-day CPD (mean changes were 2.2 and 2.9 CPD). However a minority averaged changing by ≥5 CPD from one day to the next (7% and 11%), and many changed by ≥5 CPD on at least 10 of the 90 days (8% and 31%). Neither smoking restrictions, dependence, stereotypy ratings, nor interest in quitting predicted variability. Although on average, smokers have little change day-to-day CPD, a substantial minority of smokers often change by 5 CPD from day-to-day. We did not find potential causes of this variability. Across day variability in CPD is larger than implied in prior studies. Determining causes of day-to-day variability should increase our understanding of the determinants of smoking. © The Author 2017. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Variability of extreme weather events over the equatorial East Africa, a case study of rainfall in Kenya and Uganda

NASA Astrophysics Data System (ADS)

Ongoma, Victor; Chen, Haishan; Omony, George William

2018-01-01

This study investigates the variability of extreme rainfall events over East Africa (EA), using indices from the World Meteorological Organization (WMO) Expert Team on Climate Change Detection and Indices (ETCCDI). The analysis was based on observed daily rainfall from 23 weather stations, with length varying within 1961 and 2010. The indices considered are: wet days ( R ≥1 mm), annual total precipitation in wet days (PRCPTOT), simple daily intensity index (SDII), heavy precipitation days ( R ≥ 10 mm), very heavy precipitation days ( R ≥ 20 mm), and severe precipitation ( R ≥ 50 mm). The non-parametric Mann-Kendall statistical analysis was carried out to identify trends in the data. Temporal precipitation distribution was different from station to station. Almost all indices considered are decreasing with time. The analysis shows that the PRCPTOT, very heavy precipitation, and severe precipitation are generally declining insignificantly at 5 % significant level. The PRCPTOT is evidently decreasing over Arid and Semi-Arid Land (ASAL) as compared to other parts of EA. The number of days that recorded heavy rainfall is generally decreasing but starts to rise in the last decade although the changes are insignificant. Both PRCPTOT and heavy precipitation show a recovery in trend starting in the 1990s. The SDII shows a reduction in most areas, especially the in ASAL. The changes give a possible indication of the ongoing climate variability and change which modify the rainfall regime of EA. The results form a basis for further research, utilizing longer datasets over the entire region to reduce the generalizations made herein. Continuous monitoring of extreme events in EA is critical, given that rainfall is projected to increase in the twenty-first century.

Knowledge representation and qualitative simulation of salmon redd functioning. Part II: qualitative model of redds.

PubMed

Guerrin, F; Dumas, J

2001-02-01

This paper describes a qualitative model of the functioning of salmon redds (spawning areas of salmon) and its impact on mortality rates of early stages. For this, we use Qsim, a qualitative simulator, which appeared adequate for representing available qualitative knowledge of freshwater ecology experts (see Part I of this paper). Since the number of relevant variables was relatively large, it appeared necessary to decompose the model into two parts, corresponding to processes occurring at separate time-scales. A qualitative clock allows us to submit the simulation of salmon developmental stages to the calculation of accumulated daily temperatures (degree-days), according to the clock ticks and a water temperature regime set by the user. Therefore, this introduces some way of real-time dating and duration in a purely qualitative model. Simulating both sub-models, either separately or by means of alternate transitions, allows us to generate the evolutions of variables of interest, such as the mortality rates according to two factors (flow of oxygenated water and plugging of gravel interstices near the bed surface), under various scenarios.

Disruption of the European climate seasonal clock in a warming world

NASA Astrophysics Data System (ADS)

Cattiaux, J.; Cassou, C.

2015-12-01

Strength and inland penetration of the oceanic westerly flow over Europe control a large part of the temperature variability over most of the continent. Reduced westerlies, linked to high-pressure anomalies over Scandinavia, induce cold conditions in winter and warm conditions in summer. Here we propose to define the onset of these two seasons as the calendar day where the daily circulation/temperature relationship over Western Europe switches sign. According to this meteorologically-based metrics assessed from several observational datasets, we provide robust evidence for an earlier summer onset by ~10 days between the 1960s and 2000s. Results from model ensemble simulations dedicated to detection-attribution show that this calendar advance is incompatible with the sole internal climate variability and can be attributed to anthropogenic forcings. Late winter snow disappearance over Eastern Europe affects cold air intrusion to the West when easterlies blow, and is mainly responsible for the observed present-day and near-future summer advance. Our findings agree with phenological-based trends (earlier spring events) reported for many living species over Europe, for which they provide a novel dynamical interpretation beyond the traditionally evoked global warming effect. Based on business-as-usual scenario, a seasonal shift of ~25 days is expected by 2100 for summer onset, while no clear signal arises for winter onset.

Changes in the relative population size of selected ruminal bacteria following an induced episode of acidosis in beef heifers receiving viable and non-viable active dried yeast.

PubMed

Mohammed, R; Vyas, D; Yang, W Z; Beauchemin, K A

2017-06-01

To characterize the changes in the relative population size (RPS) of select ruminal bacteria and rumen fermentation variables in beef heifers supplemented with a strain of Saccharomyces cerevisiae as viable active dried (ADY) or killed dried (KDY) yeast following an induced episode of ruminal acidosis. Six ruminally cannulated beef heifers fed a diet consisting of 50% forage and 50% grain (dry matter basis) were used in a replicated 3 × 3 Latin square design with three 28-day periods. Treatments were: (i) control (CTRL; no yeast); (ii) ADY (4 g day -1 providing 10 10  CFU per g; AB Vista, UK); and (iii) KDY (4 g day -1 autoclaved ADY). The acidosis challenge was induced on day 22 and rumen samples were collected on day 15 (baseline; BASE), day 22 (challenge day; CHAL), and on day 29 (168th hour post acid challenge or recovery, REC) of each period. Over the study, duration of pH <5·8 (indicative of subacute ruminal acidosis) was less for ADY and KDY than CTRL, with ADY less than KDY. No treatment effects were observed on relative abundance of ruminal bacteria, but the day effect was significant. The RPS of lactate producers and utilizers was greater while RPS of fibrolytic bacteria was lower during CHAL than BASE and REC. Yeast supplementation, irrespective of its viability, showed beneficial effects on ruminal pH variables in animals more susceptible to acidosis. Rumen microbial population was altered with the induction of severe acidosis. Most of the changes reverted back to baseline values during the recovery phase. Yeast supplementation reduced subacute rumen acidosis in the most susceptible cattle, but failed to attenuate severe acidosis induced by a grain challenge. The study provided valuable insight into the mechanism by which acidosis affects cattle performance. Individual animal variation in ruminal fermentation partly explained the variability in response to yeast supplementation in the study. © 2017 Her Majesty the Queen in Right of Canada. Journal of Applied Microbiology © 2017 The Society for Applied Microbiology.

The near-infrared counterpart of a variable galactic plane radio source

NASA Technical Reports Server (NTRS)

Margon, Bruce; Phillips, Andrew C.; Ciardullo, Robin; Jacoby, George H.

1992-01-01

A near-infrared counterpart to the highly variable, unresolved galactic plane radio source GT 0116 + 622 is identified. This source is of particular interest, as it has been previously suggested to be the counterpart of the gamma-ray source Cas gamma-l. The present NIR and red images detect a faint, spatially extended (3 arcsec FWHM), very red object coincident with the radio position. There is complex spatial structure which may be due in part to an unrelated superposed foreground object. Observations on multiple nights show no evidence for flux variability, despite the high amplitude variability on a time-scale of days reported for the radio source. The data are consistent with an interpretation of GT 0116 + 622 as an unusually variable, obscured active galaxy at a distance of several hundred megaparsecs, although more exotic, and in particular galactic, interpretations cannot yet be ruled out. If the object is extragalactic, the previously suggested identification with the gamma-ray source would seem unlikely.

Negotiating the boundary between paid and unpaid hospice workers: a qualitative study of how hospice volunteers understand their work.

PubMed

Field-Richards, Sarah E; Arthur, Antony

2012-12-01

To explore the nurse-volunteer relationship in a day hospice. Underpinned by an interpretive approach, face-to-face semistructured interviews were conducted with 12 day hospice volunteers. The nature and dynamics of the relationship between nursing staff and volunteers within the day hospice were characterized by increasing formality and changes in the division of labor, which challenged smooth working relationships. Volunteers see their role as becoming increasingly formalized partly as a response to increasing administrative demands on hospice nurses. The willingness of volunteers to take on new roles is variable. For volunteers to feel secure and valued and working relationships to remain strong, the process of how boundaries between paid and unpaid workers are negotiated needs to be transparent.

Diurnal and nocturnal skin temperature regulation in chronic complex regional pain syndrome.

PubMed

Schilder, Johanna C M; Niehof, Sjoerd P; Marinus, Johan; van Hilten, Jacobus J

2015-03-01

Skin temperature changes due to vasomotor disturbances are important features of complex regional pain syndrome (CRPS). Because this phenomenon has only been studied under controlled conditions, information on daily circadian variability is lacking. Also, studies in chronic CRPS patients with abnormal posturing, in which coldness of the affected extremity is more common, do not exist. We examined the response to external heating as well as circadian temperature changes over several days in the affected legs of 14 chronic CRPS patients with abnormal posturing and 17 controls. Skin temperatures were recorded hourly for 14 days using wireless sensors. Although the patients' affected extremities were significantly colder before external heating, the vasodilatory response was similar in the 2 groups. Additionally, median skin temperature differences between both legs and their variability was larger in patients than in controls during the day, but not during the night. These findings indicate that the mechanisms underlying impaired skin circulation in CRPS during daytime are reversible under certain circumstances. The large variation in skin temperature differences during the day questions the validity of using a single measurement in the diagnosis of CRPS, and our results indicate that only temperature differences >1.0 °C should be considered to reflect vasomotor disturbances. This article shows that chronic CRPS patients have a normal vasodilatory response to external heating and that skin temperature differences between the affected and unaffected lower limbs, which were highly variable during daytime, disappeared during sleep. This indicates that part of the vasomotor regulation in these patients is still functional. Copyright © 2015 American Pain Society. Published by Elsevier Inc. All rights reserved.

Variability of Massive Young Stellar Objects in Cygnus-X

NASA Astrophysics Data System (ADS)

Thomas, Nancy H.; Hora, J. L.; Smith, H. A.

2013-01-01

Young stellar objects (YSOs) are stars in the process of formation. Several recent investigations have shown a high rate of photometric variability in YSOs at near- and mid-infrared wavelengths. Theoretical models for the formation of massive stars (1-10 solar masses) remain highly idealized, and little is known about the mechanisms that produce the variability. An ongoing Spitzer Space Telescope program is studying massive star formation in the Cygnus-X region. In conjunction with the Spitzer observations, we have conducted a ground-based near-infrared observing program of the Cygnus-X DR21 field using PAIRITEL, the automated infrared telescope at Whipple Observatory. Using the Stetson index for variability, we identified variable objects and a number of variable YSOs in our time-series PAIRITEL data of DR21. We have searched for periodicity among our variable objects using the Lomb-Scargle algorithm, and identified periodic variable objects with an average period of 8.07 days. Characterization of these variable and periodic objects will help constrain models of star formation present. This work is supported in part by the NSF REU and DOD ASSURE programs under NSF grant no. 0754568 and by the Smithsonian Institution.

Methods for estimating magnitude and frequency of 1-, 3-, 7-, 15-, and 30-day flood-duration flows in Arizona

USGS Publications Warehouse

Kennedy, Jeffrey R.; Paretti, Nicholas V.; Veilleux, Andrea G.

2014-01-01

Regression equations, which allow predictions of n-day flood-duration flows for selected annual exceedance probabilities at ungaged sites, were developed using generalized least-squares regression and flood-duration flow frequency estimates at 56 streamgaging stations within a single, relatively uniform physiographic region in the central part of Arizona, between the Colorado Plateau and Basin and Range Province, called the Transition Zone. Drainage area explained most of the variation in the n-day flood-duration annual exceedance probabilities, but mean annual precipitation and mean elevation were also significant variables in the regression models. Standard error of prediction for the regression equations varies from 28 to 53 percent and generally decreases with increasing n-day duration. Outside the Transition Zone there are insufficient streamgaging stations to develop regression equations, but flood-duration flow frequency estimates are presented at select streamgaging stations.

A systematic approach to evaluate parameter consistency in the inlet stream of source separated biowaste composting facilities: A case study in Colombia.

PubMed

Oviedo-Ocaña, E R; Torres-Lozada, P; Marmolejo-Rebellon, L F; Torres-López, W A; Dominguez, I; Komilis, D; Sánchez, A

2017-04-01

Biowaste is commonly the largest fraction of municipal solid waste (MSW) in developing countries. Although composting is an effective method to treat source separated biowaste (SSB), there are certain limitations in terms of operation, partly due to insufficient control to the variability of SSB quality, which affects process kinetics and product quality. This study assesses the variability of the SSB physicochemical quality in a composting facility located in a small town of Colombia, in which SSB collection was performed twice a week. Likewise, the influence of the SSB physicochemical variability on the variability of compost parameters was assessed. Parametric and non-parametric tests (i.e. Student's t-test and the Mann-Whitney test) showed no significant differences in the quality parameters of SSB among collection days, and therefore, it was unnecessary to establish specific operation and maintenance regulations for each collection day. Significant variability was found in eight of the twelve quality parameters analyzed in the inlet stream, with corresponding coefficients of variation (CV) higher than 23%. The CVs for the eight parameters analyzed in the final compost (i.e. pH, moisture, total organic carbon, total nitrogen, C/N ratio, total phosphorus, total potassium and ash) ranged from 9.6% to 49.4%, with significant variations in five of those parameters (CV>20%). The above indicate that variability in the inlet stream can affect the variability of the end-product. Results suggest the need to consider variability of the inlet stream in the performance of composting facilities to achieve a compost of consistent quality. Copyright © 2017 Elsevier Ltd. All rights reserved.

On the day-to-day variation of the equatorial electrojet during quiet periods

NASA Astrophysics Data System (ADS)

Yamazaki, Y.; Richmond, A. D.; Maute, A.; Liu, H.-L.; Pedatella, N.; Sassi, F.

2014-08-01

It has been known for a long time that the equatorial electrojet varies from day to day even when solar and geomagnetic activities are very low. The quiet time day-to-day variation is considered to be due to irregular variability of the neutral wind, but little is known about how variable winds drive the electrojet variability. We employ a numerical model introduced by Liu et al. (2013), which takes into account weather changes in the lower atmosphere and thus can reproduce ionospheric variability due to forcing from below. The simulation is run for May and June 2009. Constant solar and magnetospheric energy inputs are used so that day-to-day changes will arise only from lower atmospheric forcing. The simulated electrojet current shows day-to-day variability of ±25%, which produces day-to-day variations in ground level geomagnetic perturbations near the magnetic equator. The current system associated with the day-to-day variation of the equatorial electrojet is traced based on a covariance analysis. The current pattern reveals return flow at both sides of the electrojet, in agreement with those inferred from ground-based magnetometer data in previous studies. The day-to-day variation in the electrojet current is compared with those in the neutral wind at various altitudes, latitudes, and longitudes. It is found that the electrojet variability is dominated by the zonal wind at 100-120 km altitudes near the magnetic equator. These results suggest that the response of the zonal polarization electric field to variable zonal winds is the main source of the day-to-day variation of the equatorial electrojet during quiet periods.

A new `bio-comfort' perspective for Melbourne based on heat stress, air pollution and pollen

NASA Astrophysics Data System (ADS)

Jacobs, Stephanie J.; Pezza, Alexandre B.; Barras, Vaughan; Bye, John

2014-03-01

Humans are at risk from exposure to extremes in their environment, yet there is no consistent way to fully quantify and understand the risk when considering more than just meteorological variables. An outdoor `bio-comfort' threshold is defined for Melbourne, Australia using a combination of heat stress, air particulate concentration and grass pollen count, where comfortable conditions imply an ideal range of temperature, humidity and wind speed, acceptable levels of air particulates and a low pollen count. This is a new approach to defining the comfort of human populations. While other works have looked into the separate impacts of different variables, this is the first time that a unified bio-comfort threshold is suggested. Composite maps of surface pressure are used to illustrate the genesis and evolution of the atmospheric structures conducive to an uncomfortable day. When there is an uncomfortable day due to heat stress conditions in Melbourne, there is a high pressure anomaly to the east bringing warm air from the northern interior of Australia. This anomaly is part of a slow moving blocking high originating over the Indian Ocean. Uncomfortable days due to high particulate levels have an approaching cold front. However, for air particulate cases during the cold season there are stable atmospheric conditions enhanced by a blocking high emanating from Australia and linking with the Antarctic continent. Finally, when grass pollen levels are high, there are northerly winds carrying the pollen from rural grass lands to Melbourne, due to a stationary trough of low pressure inland. Analysis into days with multiple types of stress revealed that the atmospheric signals associated with each type of discomfort are present regardless of whether the day is uncomfortable due to one or multiple variables. Therefore, these bio-comfort results are significant because they offer a degree of predictability for future uncomfortable days in Melbourne.

A new 'bio-comfort' perspective for Melbourne based on heat stress, air pollution and pollen.

PubMed

Jacobs, Stephanie J; Pezza, Alexandre B; Barras, Vaughan; Bye, John

2014-03-01

Humans are at risk from exposure to extremes in their environment, yet there is no consistent way to fully quantify and understand the risk when considering more than just meteorological variables. An outdoor 'bio-comfort' threshold is defined for Melbourne, Australia using a combination of heat stress, air particulate concentration and grass pollen count, where comfortable conditions imply an ideal range of temperature, humidity and wind speed, acceptable levels of air particulates and a low pollen count. This is a new approach to defining the comfort of human populations. While other works have looked into the separate impacts of different variables, this is the first time that a unified bio-comfort threshold is suggested. Composite maps of surface pressure are used to illustrate the genesis and evolution of the atmospheric structures conducive to an uncomfortable day. When there is an uncomfortable day due to heat stress conditions in Melbourne, there is a high pressure anomaly to the east bringing warm air from the northern interior of Australia. This anomaly is part of a slow moving blocking high originating over the Indian Ocean. Uncomfortable days due to high particulate levels have an approaching cold front. However, for air particulate cases during the cold season there are stable atmospheric conditions enhanced by a blocking high emanating from Australia and linking with the Antarctic continent. Finally, when grass pollen levels are high, there are northerly winds carrying the pollen from rural grass lands to Melbourne, due to a stationary trough of low pressure inland. Analysis into days with multiple types of stress revealed that the atmospheric signals associated with each type of discomfort are present regardless of whether the day is uncomfortable due to one or multiple variables. Therefore, these bio-comfort results are significant because they offer a degree of predictability for future uncomfortable days in Melbourne.

On the temporal and spatial characteristics of tornado days in the United States

NASA Astrophysics Data System (ADS)

Moore, Todd W.

2017-02-01

More tornadoes are produced per year in the United States than in any other country, and these tornadoes have produced tremendous losses of life and property. Understanding how tornado activity will respond to climate change is important if we wish to prepare for future changes. Trends in various tornado and tornado day characteristics, including their annual frequencies, their temporal variability, and their spatial distributions, have been reported in the past few years. This study contributes to this body of literature by further analyzing the temporal and spatial characteristics of tornado days in the United States. The analyses performed in this study support previously reported findings in addition to providing new perspectives, including that the temporal trends are observed only in low-frequency and high-frequency tornado days and that the eastward shift in tornado activity is produced, in part, by the increasing number of high-frequency tornado days, which tend to occur to the east of the traditionally depicted tornado alley in the Great Plains.

Shortwave surface radiation network for observing small-scale cloud inhomogeneity fields

NASA Astrophysics Data System (ADS)

Lakshmi Madhavan, Bomidi; Kalisch, John; Macke, Andreas

2016-03-01

As part of the High Definition Clouds and Precipitation for advancing Climate Prediction Observational Prototype Experiment (HOPE), a high-density network of 99 silicon photodiode pyranometers was set up around Jülich (10 km × 12 km area) from April to July 2013 to capture the small-scale variability of cloud-induced radiation fields at the surface. In this paper, we provide the details of this unique setup of the pyranometer network, data processing, quality control, and uncertainty assessment under variable conditions. Some exemplary days with clear, broken cloudy, and overcast skies were explored to assess the spatiotemporal observations from the network along with other collocated radiation and sky imager measurements available during the HOPE period.

Astrometry with Hubble Space Telescope Fine Guidance Sensor 3: The Parallax of the Cataclysmic Variable RW Triangulum

NASA Astrophysics Data System (ADS)

McArthur, B. E.; Benedict, G. F.; Lee, J.; Lu, C.-L.; van Altena, W. F.; Deliyannis, C. P.; Girard, T.; Fredrick, L. W.; Nelan, E.; Duncombe, R. L.; Hemenway, P. D.; Jefferys, W. H.; Shelus, P. J.; Franz, O. G.; Wasserman, L. H.

1999-07-01

RW Triangulum (RW Tri) is a 13th magnitude nova-like cataclysmic variable star with an orbital period of 0.2319 days (5.56 hr). Infrared observations of RW Tri indicate that its secondary is most likely a late-K dwarf (Dhillon). Past analyses predicted a distance of 270 pc, derived from a blackbody fit to the spectrum of the central part of the disk (Rutten, van Paradijs, & Tinbergen). Recently completed Hubble Space Telescope Fine Guidance Sensor interferometric observations allow us to determine the first trigonometric parallax to RW Tri. This determination puts the distance of RW Tri at 341-31+38, one of the most distant objects with a direct parallax measurement. We compare our result with methods previously employed to estimate distances to cataclysmic variables.

ARAGO: a robotic observatrory for the variable sky

NASA Astrophysics Data System (ADS)

Boer, Michel; Acker, Agnes; Atteia, Jean-Luc; Buchholtz, Gilles; Colas, Francois; Deleuil, Magali; Dennefeld, Michel; Desert, Jean-Michel; Dolez, Noel; Eysseric, J.; Ferlet, Roger; Ferrari, Marc; Jean, Pierre; Klotz, Alain; Kouach, Driss; Lecavelier des Etangs, Alain; Lemaitre, Gerard R.; Marcowith, Alexandre; Marquette, Jean-Babtiste; Meunier, Jean-Pierre; Mochkovitch, Robert; Pain, Reynald; Pares, Laurent; Pinna, Henri; Pinna, Roger; Provost, Lionel; Roques, Sylvie; Schneider, Jean; Sivan, Jean-Pierre; Soubiran, Caroline; Thiebaut, Carole; Vauclair, Gerard; Verchere, Richard; Vidal-Madjar, Alfred

2002-12-01

We present the Advanced Robotic Agile Observatory (ARAGO), a project for a large variability survey of the sky, in the range 10-8Hz (year) to 1Hz. Among its scientific objectives are the detection of cosmic gamma-ray bursts, both on alert and serendipitously, orphan afterglows, extrasolar planets, AGNs, quasar microlensing, variable and flare stars, trans-neptunian asteroids, Earth-grazers, orbital debris, etc. A large Education and Public Outreach program will be an important part of the project. The telescope itself will be made of Silicon Carbide, allowing, among other advantages, a very light weight and agile capabilities. ARAGO will be fully autonomous, i.e. there will be no human intervention from the request to the data processing and result dissemination, nor to assist night or day operations. ARAGO will start routine observation by mid-2005.

Isolated supravalvular pulmonary stenosis in a 25-day-old newborn infant: an occasional and early diagnosis.

PubMed

Patanè, Salvatore; Marte, Filippo; Di Bella, Gianluca; Di Tommaso, Eleonora; Pagano, Giuseppina Tindara; Coglitore, Sebastiano

2009-04-03

Pulmonary stenosis comprises variable pathologic features from the right ventricular outflow tract to the peripheral pulmonary arteries. Most frequently, the obstruction occurs at the level of the pulmonary valve; however, it occurs less frequently at the infindibular level. It can occur as part of more congenital cardiac malformations such as tetralogy of Fallot, complete transposition of great arteries, or atrial septal defect. Proximal pulmonary artery stenosis has also been reported as an acquired lesion in infants treated for congenital heart disease. Primary isolated supravalvular pulmonary stenosis is less common. We present a case of primary isolated pulmonary artery stenosis in an asymptomatic 25-day-old newborn infant.

Regulation of autonomic nervous system in space and magnetic storms.

PubMed

Baevsky, R M; Petrov, V M; Chernikova, A G

1998-01-01

Variations in the earth's magnetic field and magnetic storms are known to be a risk factor for the development of cardiovascular disorders. The main "targets" for geomagnetic perturbations are the central nervous system and the neural regulation of vascular tone and heart rate variability. This paper presents the data about effect of geomagnetic fluctuations on human body in space. As a method for research the analysis of heart rate variability was used, which allows evaluating the state of the sympathetic and parasympathetic parts of the autonomic nervous system, vasomotor center and subcortical neural centers activity. Heart rate variability data were analyzed for 30 cosmonauts at the 2nd day of space flight on transport spaceship Soyuz (32nd orbit). There were formed three groups of cosmonauts: without magnetic storm (n=9), on a day with magnetic storm (n=12) and 1-2 days after magnetic storm (n=9). The present study was the first to demonstrate a specific impact of geomagnetic perturbations on the system of autonomic circulatory control in cosmonauts during space flight. The increasing of highest nervous centers activity was shown for group with magnetic storms, which was more significant on 1-2 days after magnetic storm. The use of discriminate analysis allowed to classify indicated three groups with 88% precision. Canonical variables are suggested to be used as criterions for evaluation of specific and non-specific components of cardiovascular reactions to geomagnetic perturbations. The applied aspect of the findings from the present study should be emphasized. They show, in particular, the need to supplement the medical monitoring of cosmonauts with predictions of probable geomagnetic perturbations in view of the prevention of unfavorable states appearances if the adverse reactions to geomagnetic perturbations are added to the tension experienced by regulatory systems during various stresses situations (such as work in the open space).

SeaWiFS technical report series. Volume 32: Level-3 SeaWiFS data products. Spatial and temporal binning algorithms

NASA Technical Reports Server (NTRS)

Hooker, Stanford B. (Editor); Firestone, Elaine R. (Editor); Acker, James G. (Editor); Campbell, Janet W.; Blaisdell, John M.; Darzi, Michael

1995-01-01

The level-3 data products from the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) are statistical data sets derived from level-2 data. Each data set will be based on a fixed global grid of equal-area bins that are approximately 9 x 9 sq km. Statistics available for each bin include the sum and sum of squares of the natural logarithm of derived level-2 geophysical variables where sums are accumulated over a binning period. Operationally, products with binning periods of 1 day, 8 days, 1 month, and 1 year will be produced and archived. From these accumulated values and for each bin, estimates of the mean, standard deviation, median, and mode may be derived for each geophysical variable. This report contains two major parts: the first (Section 2) is intended as a users' guide for level-3 SeaWiFS data products. It contains an overview of level-0 to level-3 data processing, a discussion of important statistical considerations when using level-3 data, and details of how to use the level-3 data. The second part (Section 3) presents a comparative statistical study of several binning algorithms based on CZCS and moored fluorometer data. The operational binning algorithms were selected based on the results of this study.

[Implementation of the recommendations for psychotherapy after psychiatric inpatient treatment : Results of the PAKT study Part II].

PubMed

Uhlmann, C; Flammer, E; Pfiffner, C; Grempler, J; Längle, G; Eschweiler, G-W; Spießl, H; Steinert, T

2017-03-01

Waiting periods for inpatient or outpatient psychotherapeutic treatment are generally considerable. For patients treated in a psychiatric day-clinic or hospital, implementation of a recommended subsequent psychotherapeutic treatment might be difficult. In part II of the psychotherapy after hospital or day clinic (PAKT) study, we examined how the recommendation for psychotherapy can be implemented after psychiatric treatment. Three months after discharge from one of four psychiatric hospitals in southern Germany, we interviewed 306 patients who received a recommendation for psychotherapeutic treatment after their hospital stays if the recommendation was implemented successfully. Only about 12 % of the patients in the follow-up group were unable to implement the general recommendation for psychotherapy after psychiatric stay despite motivation for psychotherapeutic treatment. In the case of recommendation for outpatient psychotherapy, 20 % were unsuccessful. Predictors for successful implementation were education and employment, whereas variables like age, gender, diagnosis, or severity of disorder did not play a significant role. The relatively small percentage of unimplemented psychotherapeutic treatment is surprising at a first glance. However, the proportion recommended for psychotherapy after psychiatric stay was less than 10 %, as shown in the first part of the study (see PAKT Study Part I, doi:s00115-016-0107-z).

Spatial versus Day-To-Day Within-Lake Variability in Tropical Floodplain Lake CH4 Emissions – Developing Optimized Approaches to Representative Flux Measurements

PubMed Central

Peixoto, Roberta B.; Machado-Silva, Fausto; Marotta, Humberto; Enrich-Prast, Alex; Bastviken, David

2015-01-01

Inland waters (lakes, rivers and reservoirs) are now understood to contribute large amounts of methane (CH4) to the atmosphere. However, fluxes are poorly constrained and there is a need for improved knowledge on spatiotemporal variability and on ways of optimizing sampling efforts to yield representative emission estimates for different types of aquatic ecosystems. Low-latitude floodplain lakes and wetlands are among the most high-emitting environments, and here we provide a detailed investigation of spatial and day-to-day variability in a shallow floodplain lake in the Pantanal in Brazil over a five-day period. CH4 flux was dominated by frequent and ubiquitous ebullition. A strong but predictable spatial variability (decreasing flux with increasing distance to the shore or to littoral vegetation) was found, and this pattern can be addressed by sampling along transects from the shore to the center. Although no distinct day-to-day variability were found, a significant increase in flux was identified from measurement day 1 to measurement day 5, which was likely attributable to a simultaneous increase in temperature. Our study demonstrates that representative emission assessments requires consideration of spatial variability, but also that spatial variability patterns are predictable for lakes of this type and may therefore be addressed through limited sampling efforts if designed properly (e.g., fewer chambers may be used if organized along transects). Such optimized assessments of spatial variability are beneficial by allowing more of the available sampling resources to focus on assessing temporal variability, thereby improving overall flux assessments. PMID:25860229

Relation between sick leave and selected exposure variables among women semiconductor workers in Malaysia

PubMed Central

Chee, H; Rampal, K

2003-01-01

Aims: To determine the relation between sick leave and selected exposure variables among women semiconductor workers. Methods: This was a cross sectional survey of production workers from 18 semiconductor factories. Those selected had to be women, direct production operators up to the level of line leader, and Malaysian citizens. Sick leave and exposure to physical and chemical hazards were determined by self reporting. Three sick leave variables were used; number of sick leave days taken in the past year was the variable of interest in logistic regression models where the effects of age, marital status, work task, work schedule, work section, and duration of work in factory and work section were also explored. Results: Marital status was strongly linked to the taking of sick leave. Age, work schedule, and duration of work in the factory were significant confounders only in certain cases. After adjusting for these confounders, chemical and physical exposures, with the exception of poor ventilation and smelling chemicals, showed no significant relation to the taking of sick leave within the past year. Work section was a good predictor for taking sick leave, as wafer polishing workers faced higher odds of taking sick leave for each of the three cut off points of seven days, three days, and not at all, while parts assembly workers also faced significantly higher odds of taking sick leave. Conclusion: In Malaysia, the wafer fabrication factories only carry out a limited portion of the work processes, in particular, wafer polishing and the processes immediately prior to and following it. This study, in showing higher illness rates for workers in wafer polishing compared to semiconductor assembly, has implications for the governmental policy of encouraging the setting up of wafer fabrication plants with the full range of work processes. PMID:12660374

Seasonal forecasts of impact-relevant climate information indices developed as part of the EUPORIAS project

NASA Astrophysics Data System (ADS)

Spirig, Christoph; Bhend, Jonas

2015-04-01

Climate information indices (CIIs) represent a way to communicate climate conditions to specific sectors and the public. As such, CIIs provide actionable information to stakeholders in an efficient way. Due to their non-linear nature, such CIIs can behave differently than the underlying variables, such as temperature. At the same time, CIIs do not involve impact models with different sources of uncertainties. As part of the EU project EUPORIAS (EUropean Provision Of Regional Impact Assessment on a Seasonal-to-decadal timescale) we have developed examples of seasonal forecasts of CIIs. We present forecasts and analyses of the skill of seasonal forecasts for CIIs that are relevant to a variety of economic sectors and a range of stakeholders: heating and cooling degree days as proxies for energy demand, various precipitation and drought-related measures relevant to agriculture and hydrology, a wild fire index, a climate-driven mortality index and wind-related indices tailored to renewable energy producers. Common to all examples is the finding of limited forecast skill over Europe, highlighting the challenge for providing added-value services to stakeholders operating in Europe. The reasons for the lack of forecast skill vary: often we find little skill in the underlying variable(s) precisely in those areas that are relevant for the CII, in other cases the nature of the CII is particularly demanding for predictions, as seen in the case of counting measures such as frost days or cool nights. On the other hand, several results suggest there may be some predictability in sub-regions for certain indices. Several of the exemplary analyses show potential for skillful forecasts and prospect for improvements by investing in post-processing. Furthermore, those cases for which CII forecasts showed similar skill values as those of the underlying meteorological variables, forecasts of CIIs provide added value from a user perspective.

Changes in heart rate variability during the induction and decay of heat acclimation.

PubMed

Flouris, Andreas D; Poirier, Martin P; Bravi, Andrea; Wright-Beatty, Heather E; Herry, Christophe; Seely, Andrew J; Kenny, Glen P

2014-10-01

We evaluated the changes in core temperature, heart rate, and heart rate variability (HRV) during the induction and decay of heat acclimation. Ten males (23 ± 3 years; 79.5 ± 3.5 kg; 15.2 ± 4.5 percent body fat; 51.13 ± 4.61 mLO(2)∙kg(-1)∙min(-1) peak oxygen uptake) underwent a 14-day heat acclimation protocol comprising of 90-min cycling at ~50 % peak oxygen uptake at 40 °C and ~20 % relative humidity. Core temperature, heart rate, and 102 HRV measures were recorded during a heat tolerance test conducted at baseline (day 0) and at the end of the induction (day 14) and decay (day 28) phases. Heat acclimation resulted in significantly reduced core temperature [rectal (χ (2) = 1298.14, p < 0.001); esophageal (χ (2) = 1069.88, p < 0.001)] and heart rate (χ (2) = 1230.17, p < 0.001). Following the decay phase, 26, 40, and 60 % of the heat acclimation-induced reductions in rectal temperature, esophageal temperature, and heart rate, respectively, were lost. Heat acclimation was accompanied by profound and broad changes in HRV: at the end of the induction phase, 75 of the 102 variability measures computed were significantly different (p < 0.001), compared to only 47 of the 102 at the end of the decay phase. Heat acclimation is accompanied by reduced core temperature, significant bradycardia, and marked alterations in HRV, which we interpret as being related to vagal dominance. The observed changes in core temperature persist for at least 2 weeks of non-exposure to heat, while the changes in heart rate and HRV decay faster and are only partly evident after 2 weeks of non-exposure to heat.

Evaluation of markers out of the steroid profile for the screening of testosterone misuse. Part I: Transdermal administration.

PubMed

Kotronoulas, Aristotelis; Gomez-Gómez, Àlex; Fabregat, Andreu; Segura, Jordi; Yang, Sheng; Xing, Yanyi; Moutian, Wu; Marcos, Josep; Joglar, Jesús; Ventura, Rosa; Pozo, Oscar J

2018-05-01

Although the introduction by the World Anti-Doping Agency (WADA) of the steroid module of the athlete biological passport (ABP) marked an important step forward in the screening of testosterone (T) misuse, it still remains one of the most difficult challenges in doping control analysis. The urinary determination of alternative markers has been recently reported as a promising tool for improving the screening of T oral administration. However, their evaluation for other, commonly used, administration routes is still required. The main goal of this study is the evaluation of the potential of 2 groups of metabolites (cysteinyl conjugated and glucuronoconjugated) after transdermal and intramuscular administration of T. Their suitability was evaluated in individuals with both low basal (L-T/E) and medium basal (M-T/E) values of T/E. In this Part I, we evaluated the urinary excretion profile of these 2 groups of T metabolites after the administration of 3 doses of T gel to 12 volunteers (6 L-T/E and 6 M-T/E) for 3 consecutive days. For this purpose, 9 different concentration ratios (5 cysteinyl conjugated and 4 glucuronoconjugated markers) were studied. Both, the intra-individual variability and the detection windows (DW) obtained by each ratio were evaluated. Cysteinyl conjugates showed a general low intra-individual variability and DWs that were shorter than any other tested marker. Despite the relatively large intra-individual variability, the DWs reached by glucuronoconjugates (2-3 days) were similar to those obtained by markers currently included in the ABP. Overall; this evaluation advises for the introduction of additional glucuronoconjugated markers in the screening of transdermal T administration. Copyright © 2017 John Wiley & Sons, Ltd.

Twitter as a Potential Disaster Risk Reduction Tool. Part III: Evaluating Variables that Promoted Regional Twitter Use for At-risk Populations During the 2013 Hattiesburg F4 Tornado.

PubMed

Cooper, Guy Paul; Yeager, Violet; Burkle, Frederick M; Subbarao, Italo

2015-06-29

Study goals attempt to identify the variables most commonly associated with successful tweeted messages and determine which variables have the most influence in promoting exponential dissemination of information (viral spreading of the message) and trending (becoming popular) in the given disaster affected region. Part II describes the detailed extraction and triangulation filtration methodological approach to acquiring twitter data for the 2013 Hattiesburg Tornado. The data was then divided into two 48 hour windows before and after the tornado impact with a 2 hour pre-tornado buffer to capture tweets just prior to impact. Criteria-based analysis was completed for Tweets and users. The top 100 pre-Tornado and post-Tornado retweeted users were compared to establish the variability among the top retweeted users during the 4 day span.  Pre-Tornado variables that were correlated to higher retweeted rates include total user tweets (0.324), and total times message retweeted (0.530).  Post-Tornado variables that were correlated to higher retweeted rates include total hashtags in a retweet (0.538) and hashtags #Tornado (0.378) and #Hattiesburg (0.254). Overall hashtags usage significantly increased during the storm. Pre-storm there were 5,763 tweets with a hashtag and post-storm there was 13,598 using hashtags. Twitter's unique features allow it to be considered a unique social media tool applicable for emergency managers and public health officials for rapid and accurate two way communication.  Additionally, understanding how variables can be properly manipulated plays a key role in understanding how to use this social media platform for effective, accurate, and rapid mass information communication.

Twitter as a Potential Disaster Risk Reduction Tool. Part III: Evaluating Variables that Promoted Regional Twitter Use for At-risk Populations During the 2013 Hattiesburg F4 Tornado

PubMed Central

Cooper, Guy Paul; Yeager, Violet; Burkle, Frederick M.; Subbarao, Italo

2015-01-01

Introduction: Study goals attempt to identify the variables most commonly associated with successful tweeted messages and determine which variables have the most influence in promoting exponential dissemination of information (viral spreading of the message) and trending (becoming popular) in the given disaster affected region. Methods: Part II describes the detailed extraction and triangulation filtration methodological approach to acquiring twitter data for the 2013 Hattiesburg Tornado. The data was then divided into two 48 hour windows before and after the tornado impact with a 2 hour pre-tornado buffer to capture tweets just prior to impact. Criteria-based analysis was completed for Tweets and users. The top 100 pre-Tornado and post-Tornado retweeted users were compared to establish the variability among the top retweeted users during the 4 day span.  Results: Pre-Tornado variables that were correlated to higher retweeted rates include total user tweets (0.324), and total times message retweeted (0.530).  Post-Tornado variables that were correlated to higher retweeted rates include total hashtags in a retweet (0.538) and hashtags #Tornado (0.378) and #Hattiesburg (0.254). Overall hashtags usage significantly increased during the storm. Pre-storm there were 5,763 tweets with a hashtag and post-storm there was 13,598 using hashtags. Conclusions: Twitter’s unique features allow it to be considered a unique social media tool applicable for emergency managers and public health officials for rapid and accurate two way communication.  Additionally, understanding how variables can be properly manipulated plays a key role in understanding how to use this social media platform for effective, accurate, and rapid mass information communication.  PMID:26203397

Changes in the intensity of Mediterranean precipitation: a comparison of east/west trends and their causes

NASA Astrophysics Data System (ADS)

Goodess, C. M.; Jones, P. D.

2003-04-01

Changes in the frequency and intensity of precipitation over the last 40 years have been investigated for the Iberian Peninsula and Greece. Over much of the Mediterranean the general tendency is towards decreasing precipitation, but the pattern of change is complex, particularly with respect to extremes. Over most of the Iberian Peninsula, the last 40 years has seen a trend towards more, but less wet rain days. However, in southeast Spain, the reverse has occurred, with more wet days with high precipitation amounts. Over Greece, the main tendency is towards fewer rain days, with little change in rain day amount, which is strongest over the Ionian and Aegean Seas and in winter. A few places, such as Rhodes, do however, show a weak trend towards more intense precipitation events in autumn. The precipitation changes observed over the Iberian Peninsula can, in part, be explained by changes in atmospheric circulation. They are associated with a decrease in the frequency of cyclonic circulation types and increases in the frequency of anticyclonic, easterly and south-easterly types (which can in turn be linked with changes in the intensity of the North Atlantic Oscillation and the frequency and intensity of Mediterranean and Atlantic cyclones). However, precipitation trends simulated by regression models with circulation-type frequency as the predictor variables are weaker than observed. The observed changes in circulation-type frequency over Greece (such as the increase in the frequency of the 'high-precipitation' cyclonic types and decrease in the 'low-precipitation' anticyclonic types) indicate an increase in precipitation. This is in contrast to the observed precipitation decreases. All the regression models underestimate year-to-year variability, and have problems in reproducing the observed trends. The common problems in both regions indicate that different forms of model may be required. The finding that the selected predictor variables are more successful at reproducing the observed precipitation trends in Spain than Greece, indicates different underlying physical processes which require further investigation. Goodess, CM and Jones, PD, 2002: Links between circulation and changes in the characteristics of Iberian precipitation, Int. J. Climatol. 22, 1593-1615. Acknowledgements: This work (http://www.cru.uea.ac.uk/~clareg/nerc.htm) was funded by the Commission of the European Union as part of the ACCORD project and by the UK Natural Environment Research Council.

Spatial clustering and meteorological drivers of summer ozone in Europe

NASA Astrophysics Data System (ADS)

Carro-Calvo, Leopoldo; Ordóñez, Carlos; García-Herrera, Ricardo; Schnell, Jordan L.

2017-04-01

We present a regionalization of summer near-surface ozone (O3) in Europe. For this purpose we apply a K-means algorithm on a gridded MDA8 O3 (maximum daily average 8-h ozone) dataset covering a European domain [15° W - 30° E, 35°-70° N] at 1° x 1° horizontal resolution for the 1998-2012 period. This dataset was compiled by merging observations from the European Monitoring and Evaluation Programme (EMEP) and the European Environment Agency's air quality database (AirBase). The K-means method allows identifying sets of different regions where the O3 concentrations present coherent spatiotemporal patterns and are thus expected to be driven by similar meteorological factors. After some testing, 9 regions were selected: the British Isles, North-Central Europe, Northern Scandinavia, the Baltic countries, the Iberian Peninsula, Western Europe, South-Central Europe, Eastern Europe and the Balkans. For each region we examine the synoptic situations associated with elevated ozone extremes (days exceeding the 95th percentile of the summer MDA8 O3 distribution). Our analyses reveal that there are basically two different kinds of regions in Europe: (a) those in the centre and south of the continent where ozone extremes are associated with elevated temperature within the same region and (b) those in northern Europe where ozone extremes are driven by southerly advection of air masses from warmer, more polluted areas. Even when the observed patterns were initially identified only for days registering high O3 extremes, all summer days can be projected on such patterns to identify the main modes of meteorological variability of O3. We have found that such modes are partly responsible for the day-to-day variability in the O3 concentrations and can explain a relatively large fraction (from 44 to 88 %, depending on the region) of the interannual variability of summer mean MDA8 O3 during the period of analysis. On the other hand, some major teleconnection patterns have been tested but do not seem to exert a large impact on the variability of surface O3 over most regions. The identification of these independent regions where surface ozone presents a coherent behaviour and responds similarly to specific meteorological modes of variability has multiple applications. For instance, the performance of chemical transport models (CTMs) and chemistry-climate models (CCMs) can be separately assessed over such regions to identify areas where they present large biases that need to be corrected. Our results can also be used to test the models' sensitivity to the day-to-day changing meteorology and to climate change over specific regions.

Response of western mountain ecosystems to climatic variability and change: The Western Mountain Initiative

USGS Publications Warehouse

Stephenson, Nathan L.; Peterson, Dave; Fagre, Daniel B.; Allen, Craig D.; McKenzie, Donald; Baron, Jill S.; O'Brian, Kelly

2007-01-01

Mountain ecosystems within our national parks and other protected areas provide valuable goods and services such as clean water, biodiversity conservation, and recreational opportunities, but their potential responses to expected climatic changes are inadequately understood. The Western Mountain Initiative (WMI) is a collaboration of scientists whose research focuses on understanding and predicting responses of western mountain ecosystems to climatic variability and change. It is a legacy of the Global Change Research Program initiated by the National Park Service (NPS) in 1991 and continued by the U.S. Geological Survey (USGS) to this day as part of the U.S. Climate Change Science Program (http://www.climatescience.gov/). All WMI scientists are active participants in CIRMOUNT, and seek to further its goals.

Coupled Modes over Indian Ocean at Sub-seasonal time Scales and its Prediction

NASA Astrophysics Data System (ADS)

Jung, E.; Kirtman, B. P.

2014-12-01

Sub-seasonal variability over the Indian Ocean, such as Madden-Julian Oscillation impacts weather and climate globally. However, the prediction of tropical sub-seasonal variability (TSV) remains a challenge, and understanding air-sea interactions on TSV time-scales is likely to be an important part of the prediction problem. The purpose of this paper is to examine the predictability of sub-seasonal variability in the tropical Indo-Pacific region. The analysis emphasizes on variability associated with coupled air-sea interactions in observational estimates, and how well these coupled modes are simulated and predicted within the context of a 30-year retrospective forecast experiment with a state-of-the-art atmosphere-ocean coupled model. The analysis shows that Sea Surface Temperature anomalies (SSTA) over the Indian Ocean tend to precede precipitation anomalies by 7-11 days with maximum amplitude over the Arabian Sea and the Bay of Bengal for summer and along the Seychelles-Chagos Thermocline Ridge (SCTR) region for winter. Though these coupled modes are captured by the models, the forecasts fail to predict its evolution. Based on the diagnosis of these coupled modes, we introduce a SCTR-SST index and an index that measures the modulation of the low-frequency amplitude (LFAM) of sub-seasonal SSTA variability over SCTR as a way to predict the coupled modes. Based on correlation with the observed variability, SCTR-SST has forecast skill of about 45 days over the Indian Ocean. However the sub-seasonal SSTAs in the predictions and the observational estimates do not have any direct ENSO tele-connection. In contrast, the LFAM of the sub-seasonal SSTA variance over SCTR is strongly correlated with ENSO, suggesting enhanced sub-seasonal variance on seasonal time-scales is potentially predictable.

8- to 13-micron spectroscopy of Comet Levy 1990 XX

NASA Technical Reports Server (NTRS)

Lynch, David K.; Russell, Ray W.; Hackwell, John A.; Hanner, Martha S.; Hammel, Heidi B.

1992-01-01

The results are reported of IR spectroscopy of Comet Levy 1990 XX over a three-day period when the comet was about 1.54 AU from the sun roughly 70 days before perihelion. Comet Levy 1990 XX was bright, and for at least part of its inbound journey toward perihelion, active. At a distance of 1.54 AU from the sun it showed strong structured silicate emission with peaks or shoulders at 9.8 and 11.2 microns. These features resemble those of Comets P/Halley and Bradfield 1987 XXIX. The comet was variable in brightness. Specifically, the contrast of the silicate features changed by a factor of two relative to the continuum level and showed some evidence for a shape change as well.

Long-term variability of dust events in Iceland (1949-2011)

NASA Astrophysics Data System (ADS)

Dagsson-Waldhauserova, P.; Arnalds, O.; Olafsson, H.

2014-06-01

Long-term frequency of atmospheric dust observations was investigated for the southern part of Iceland and merged with results obtained from the Northeast Iceland (Dagsson-Waldhauserova et al., 2013). In total, over 34 dust days per year on average occurred in Iceland based on conventionally used synoptic codes for dust. Including codes 04-06 into the criteria for dust observations, the frequency was 135 dust days annually. The Sea Level Pressure (SLP) oscillation controlled whether dust events occurred in NE (16.4 dust days annually) or in southern part of Iceland (about 18 dust days annually). The most dust-frequent decade in S Iceland was the 1960s while the most frequent decade in NE Iceland was the 2000s. A total of 32 severe dust storms (visibility < 500 m) was observed in Iceland with the highest frequency during the 2000s in S Iceland. The Arctic dust events (NE Iceland) were typically warm and during summer/autumn (May-September) while the Sub-Arctic dust events (S Iceland) were mainly cold and during winter/spring (March-May). About half of dust events in S Iceland occurred in winter or at sub-zero temperatures. A good correlation was found between PM10 concentrations and visibility during dust observations at the stations Vik and Storhofdi. This study shows that Iceland is among the dustiest areas of the world and dust is emitted the year-round.

Dental therapists linked to improved dental outcomes for Alaska Native communities in the Yukon-Kuskokwim Delta.

PubMed

Chi, Donald L; Lenaker, Dane; Mancl, Lloyd; Dunbar, Matthew; Babb, Michael

2018-01-29

Dental Health Aide Therapists (DHATs) have been part of the dental workforce in Alaska's Yukon-Kuskokwim (YK) Delta since 2006. They are trained to provide preventive and restorative care such as filling and extractions. In this study, we evaluated community-level dental outcomes associated with DHATs. This was a secondary data analysis of Alaska Medicaid and electronic health record data for individuals in Alaska's YK Delta (2006-2015). The independent variable was the number of DHAT treatment days in each community. Child outcomes were preventive care, extractions, and general anesthesia. Adult outcomes were preventive care and extractions. We estimated Spearman partial correlation coefficients to test our hypotheses that increased DHAT treatment days would be associated with larger proportions utilizing preventive care and smaller proportions receiving extractions at the community-level. DHAT treatment days were positively associated with preventive care utilization and negatively associated with extractions for children and adults (P < 0.0001). DHAT treatment days were not associated with increased dental treatment under general anesthesia for children. Dental therapists are associated with more preventive care and fewer extractions. State-level policies should consider dental therapists as part of a comprehensive solution to meet the dental care needs of individuals in underserved communities and help achieve health equity and social justice. © 2018 American Association of Public Health Dentistry.

Day care for dementia patients from a family caregiver's point of view: a questionnaire study on expected quality and predictors of utilisation - Part II.

PubMed

Donath, Carolin; Winkler, Angelika; Graessel, Elmar; Luttenberger, Katharina

2011-04-13

The investigation of the predictive variables for utilisation of day care and the views of family caregivers of dementia patients about quality of day care are the goals of this work. The cross-sectional study was carried out as an anonymous written survey of family caregivers of dementia patients in Germany. Participants were 404 family caregivers of dementia patients, of these 128 were users of day care, 269 were non-users and 7 gave no details about utilisation. Qualitative and quantitative data were analysed using qualitative content analysis and binary logistic regression analysis. The assessment of how helpful day care is for the individual care situation and the age of the family caregiver are significant predictors for utilisation of day care. Caregivers most frequently cited a programme of activities suited to the abilities of the dementia patients as quality criterion. In order to reduce the number of those caregivers who think they don't need day care compared with the number who really don't need it, caregivers should be transparently informed of the relevant advantages and quality principles of using day care. According to caregivers' wishes, the organisation of day care centres must include activities suited for dementia patients.

Analysis of multi-year near-surface ozone observations at the WMO/GAW "Concordia" station (75°06‧S, 123°20‧E, 3280 m a.s.l. - Antarctica)

NASA Astrophysics Data System (ADS)

Cristofanelli, Paolo; Putero, Davide; Bonasoni, Paolo; Busetto, Maurizio; Calzolari, Francescopiero; Camporeale, Giuseppe; Grigioni, Paolo; Lupi, Angelo; Petkov, Boyan; Traversi, Rita; Udisti, Roberto; Vitale, Vito

2018-03-01

This work focuses on the near-surface O3 variability over the eastern Antarctic Plateau. In particular, eight years (2006-2013) of continuous observations at the WMO/GAW contributing station "Concordia" (Dome C-DMC: 75°06‧S, 123°20‧E, 3280 m) are presented, in the framework of the Italian Antarctic Research Programme (PNRA). First, the characterization of seasonal and diurnal O3 variability at DMC is provided. Then, for the period of highest data coverage (2008-2013), we investigated the role of specific atmospheric processes in affecting near-surface summer O3 variability, when O3 enhancement events (OEEs) are systematically observed at DMC (average monthly frequency peaking up to 60% in December). As deduced by a statistical selection methodology, these OEEs are affected by a significant interannual variability, both in their average O3 values and in their frequency. To explain part of this variability, we analyzed OEEs as a function of specific atmospheric variables and processes: (i) total column of O3 (TCO) and UV-A irradiance, (ii) long-range transport of air masses over the Antarctic Plateau (by Lagrangian back-trajectory analysis - LAGRANTO), (iii) occurrence of "deep" stratospheric intrusion events (by using the Lagrangian tool STLEFLUX). The overall near-surface O3 variability at DMC is controlled by a day-to-day pattern, which strongly points towards a dominating influence of processes occurring at "synoptic" scales rather than "local" processes. Even if previous studies suggested an inverse relationship between OEEs and TCO, we found a slight tendency for the annual frequency of OEEs to be higher when TCO values are higher over DMC. The annual occurrence of OEEs at DMC seems related to the total time spent by air masses over the Antarctic plateau before their arrival to DMC, suggesting the accumulation of photochemically-produced O3 during the transport, rather than a more efficient local production. Moreover, the identification of recent (i.e., 4-day old) stratospheric intrusion events by STEFLUX suggested only a minor influence (up to 3% of the period, in November) of "deep" events on the variability of near-surface summer O3 at DMC.

The Pan-STARRS 1 Medium Deep Field Variable Star Catalog

NASA Astrophysics Data System (ADS)

Flewelling, Heather

2015-01-01

We present the first Pan-STARRS 1 Medium Deep Field Variable Star Catalog (PS1-MDF-VSC). The Pan-STARRS 1 (PS1) telescope is a 1.8 meter survey telescope with a 1.4 Gigapixel camera, located in Haleakala, Hawaii. The Medium Deep survey, which consists of 10 fields located uniformly across the sky, totalling 70 square degrees, is observed each night, in 2-3 filters per field, with 8 exposures per filter, resulting in 3000-4000 data points per star over a time span of 3.5 years. To find the variables, we select the stars with > 200 detections, between 16th and 21st magnitude. There are approximately 500k stars that fit this criteria, they then go through a lomb-scargle fitting routine to determine periodicity. After a periodicity cut, the ~400 candidates are classified by eye into different types of variable stars. We have identified several hundred variable stars, with periods ranging between a few minutes to a few days, and about half are not previously identified in the literature. We compare our results to the stripe 82 variable catalog, which overlaps part of the sky with the PS1 catalog.

The Pan-STARRS 1 Medium Deep Field Variable Star Catalog

NASA Astrophysics Data System (ADS)

Flewelling, Heather

2015-08-01

We present the first Pan-STARRS 1 Medium Deep Field Variable Star Catalog (PS1-MDF-VSC). The Pan-STARRS 1 (PS1) telescope is a 1.8 meter survey telescope with a 1.4 Gigapixel camera, located in Haleakala, Hawaii. The Medium Deep survey, which consists of 10 fields located uniformly across the sky, totalling 70 square degrees, is observed each night, in 2-3 filters per field, with 8 exposures per filter, resulting in 3000-4000 data points per star over a time span of 3.5 years. To find the variables, we select the stars with > 200 detections, between 16th and 21st magnitude. There are approximately 500k stars that fit this criteria, they then go through a lomb-scargle fitting routine to determine periodicity. After a periodicity cut, the ~400 candidates are classified by eye into different types of variable stars. We have identified several hundred variable stars, with periods ranging between a few minutes to a few days, and about half are not previously identified in the literature. We compare our results to the stripe 82 variable catalog, which overlaps part of the sky with the PS1 catalog.

The impact of glycaemic variability on wound healing in the diabetic foot - A retrospective study of new ulcers presenting to a specialist multidisciplinary foot clinic.

PubMed

Dhatariya, Ketan K; Li Ping Wah-Pun Sin, Edwin; Cheng, Joyce Oi Suet; Li, Francesca Yan Nok; Yue, Anson Wei Yue; Gooday, Catherine; Nunney, Ian

2018-01-01

Glycaemic variability - the visit-to-visit variation in HbA1c - plays a possible role in the development of micro and macrovascular disease in patients with diabetes. Whether HbA1c variability is a factor determining wound healing in diabetic foot ulcers remains unknown. We aimed to determine whether HbA1c variability is associated with foot ulcer healing time. A retrospective analysis of patients presenting to our specialist multidisciplinary foot clinic between July 2013 and March 2015, with at least three HbA1c measurements within five years of presentation and more than two follow-up reviews. HbA1c variation was measured by magnitude of standard deviation. 629 new referrals were seen between July 2013 and March 2015. Of these, 172 patients had their number of days to healing recorded and sufficient numbers of HbA1c values to determine variability. The overall geometric mean days to heal was 91.1 days (SD 80.8-102.7). In the low HbA1c variability group the geometric mean days to heal was 78.0 days (60.2-101.2) vs 126.9 days (102.0-158.0) in the high Hb1Ac variability group (p = .032). Those with low HbA1c (<58 mmol/mol) and low variability healed faster than those with high HbA1c and high variability (73.5 days [59.5-90.8] vs 111.0 days [92.0-134.0], p = .007). Additionally, our results show that time to healing is more dependent on the mean HbA1c than the variability in HbA1c (p = .007). Our data suggest that there was a significant association between HbA1c variability and healing time in diabetic foot ulcers. Copyright © 2017 Elsevier B.V. All rights reserved.

Clinical Significance of Mobile Health Assessed Sleep Duration and Variability in Bipolar Disorder

PubMed Central

Kaufmann, Christopher N.; Gershon, Anda; Eyler, Lisa T.; Depp, Colin A.

2016-01-01

OBJECTIVE Sleep disturbances are prevalent, persistent, and impairing features of bipolar disorder. However, the near-term and cumulative impact of the severity and variability of sleep disturbances on symptoms and functioning remains unclear. We examined self-reported daily sleep duration and variability in relation to mood symptoms, medication adherence, cognitive functioning, and concurrent daily affect. METHODS Forty-one outpatients diagnosed with bipolar disorder were asked to provide daily reports of sleep duration and affect collected via ecological momentary assessment with smartphones over eleven weeks. Measures of depressive and manic symptoms, medication adherence, and cognitive function were collected at baseline and concurrent assessment of affect were collected daily. Analyses examined whether sleep duration or variability were associated with baseline measures and changes in same-day or next-day affect. RESULTS Greater sleep duration variability (but not average sleep duration) was associated with greater depressive and manic symptom severity, and lower medication adherence at baseline, and with lower and more variable ratings of positive affect and higher ratings of negative affect. Sleep durations shorter than 7-8 hours were associated with lower same-day ratings of positive and higher same-day ratings of negative affect, however this did not extend to next-day affect. CONCLUSIONS Greater cumulative day-to-day sleep duration variability, but not average sleep duration, was related to more severe mood symptoms, lower self-reported medication adherence and higher levels of negative affect. Bouts of short- or long-duration sleep had transient impact on affect. Day-to-day sleep variability may be important to incorporate into clinical assessment of sleep disturbances in bipolar disorder. PMID:27451108

Clinical significance of mobile health assessed sleep duration and variability in bipolar disorder.

PubMed

Kaufmann, Christopher N; Gershon, Anda; Eyler, Lisa T; Depp, Colin A

2016-10-01

Sleep disturbances are prevalent, persistent, and impairing features of bipolar disorder. However, the near-term and cumulative impact of the severity and variability of sleep disturbances on symptoms and functioning remains unclear. We examined self-reported daily sleep duration and variability in relation to mood symptoms, medication adherence, cognitive functioning, and concurrent daily affect. Forty-one outpatients diagnosed with bipolar disorder were asked to provide daily reports of sleep duration and affect collected via ecological momentary assessment with smartphones over eleven weeks. Measures of depressive and manic symptoms, medication adherence, and cognitive function were collected at baseline and concurrent assessment of affect were collected daily. Analyses examined whether sleep duration or variability were associated with baseline measures and changes in same-day or next-day affect. Greater sleep duration variability (but not average sleep duration) was associated with greater depressive and manic symptom severity, and lower medication adherence at baseline, and with lower and more variable ratings of positive affect and higher ratings of negative affect. Sleep durations shorter than 7-8 h were associated with lower same-day ratings of positive and higher same-day ratings of negative affect, however this did not extend to next-day affect. Greater cumulative day-to-day sleep duration variability, but not average sleep duration, was related to more severe mood symptoms, lower self-reported medication adherence and higher levels of negative affect. Bouts of short- or long-duration sleep had transient impact on affect. Day-to-day sleep variability may be important to incorporate into clinical assessment of sleep disturbances in bipolar disorder. Copyright © 2016 Elsevier Ltd. All rights reserved.

An Idiographic Examination of Day-to-Day Patterns of Substance Use Craving, Negative Affect, and Tobacco Use among Young Adults in Recovery

ERIC Educational Resources Information Center

Zheng, Yao; Wiebe, Richard P.; Cleveland, H. Harrington; Molenaar, Peter C. M.; Harris, Kitty S.

2013-01-01

Psychological constructs, such as negative affect and substance use cravings that closely predict relapse, show substantial intraindividual day-to-day variability. This intraindividual variability of relevant psychological states combined with the "one day at a time" nature of sustained abstinence warrant a day-to-day investigation of substance…

Severity of electrical accidents in the construction industry in Spain.

PubMed

Suárez-Cebador, Manuel; Rubio-Romero, Juan Carlos; López-Arquillos, Antonio

2014-02-01

This paper analyzes the severity of workplace accidents involving electricity in the Spanish construction sector comprising 2,776 accidents from 2003 to 2008. The investigation considered the impact of 13 variables, classified into 5 categories: Personal, Business, Temporal, Material, and Spatial. The findings showed that electrical accidents are almost five times more likely to have serious consequences than the average accident in the sector and it also showed how the variables of age, occupation, company size, length of service, preventive measures, time of day, days of absence, physical activity, material agent, type of injury, body part injured, accident location, and type of location are related to the severity of the electrical accidents under consideration. The present situation makes it clear that greater effort needs to be made in training, monitoring, and signage to guarantee a safe working environment in relation to electrical hazards. This research enables safety technicians, companies, and government officials to identify priorities and to design training strategies to minimize the serious consequences of electrical accidents for construction workers. Copyright © 2013 Elsevier Ltd and National Safety Council. All rights reserved.

Variability of growing degree days in Poland in response to ongoing climate changes in Europe.

PubMed

Wypych, Agnieszka; Sulikowska, Agnieszka; Ustrnul, Zbigniew; Czekierda, Danuta

2017-01-01

An observed increase in air temperature can lead to significant changes in the phenology of plants and, consequently, changes in agricultural production. The aim of the study was to evaluate the spatial differentiation of thermal resources in Poland and their variability during a period of changing thermal conditions in Europe. Since the variability of thermal conditions is of paramount importance for perennial crops, the study focused on apple, plum, and cherry orchard regions in Poland. The analysis was conducted for the period of 1951-2010 using air temperature daily data. Thermal resources have been defined using the growing degree days (GDD) index calculated independently for the whole year and during in frost-free season for three air temperature thresholds: 0, 5, and 10 °C, which determine the non-winter period, growing season, and the period of full plant growth, respectively. In addition, due to the high significance for perennials in particular, the incidence and intensity of frost during flowering were calculated. In this study, a detailed analysis of the spatial differentiation of thermal resources was first performed, followed by an evaluation of long-term variability and associated change patterns. The obtained results confirmed an increase in thermal resources in Poland as a consequence of the lengthening of the growing season. However, the frequency and intensity of spring frost, especially during flowering or even during ripening of plants, remain a threat to harvests in both the eastern and western parts of the country.

Independence of heritable influences on the food intake of free-living humans.

PubMed

de Castro, John M

2002-01-01

The time of day of meal ingestion, the number of people present at the meal, the subjective state of hunger, and the estimated before-meal contents in the stomach have been established as influences on the amount eaten in a meal and these influences have been shown to be heritable. Because these factors intercorrelate, the calculated heritabilities for some of these variables might result indirectly from their covariation with one of the other heritable variables. The independence of the heritability of the influence of these four factors was investigated with 110 identical and 102 fraternal same-sex and 53 fraternal mixed-sex adult twin pairs who were paid to maintain 7-d food-intake diaries. From the diary reports, the meal sizes were calculated and subjected to multiple regression analysis using the estimated before-meal stomach contents, the reported number of other people present, the subjective hunger ratings, and the time of day of the meal as predictors. Linear structural modeling was applied to the beta-coefficients from the multiple regression to investigate whether the heritability of the influences of these four variables was independent. Significant genetic effects were found for the beta-coefficients for all four variables, indicating that the heritability of their relationship with intake is to some extent independent and heritable. This suggests that influences of multiple factors on intake are influenced by the genes and become part of the total package of genetically determined physiologic, sociocultural, and psychological processes that regulate energy balance.

Heritability of diurnal changes in food intake in free-living humans.

PubMed

de Castro, J M

2001-09-01

The time of day of meal ingestion, the number of people present at the meal, the subjective state of hunger, and the estimated before-meal contents in the stomach have been established as influences on the amount eaten in a meal, and this influence has been shown to be heritable. Because these factors intercorrelate, the possibility that the calculated heritabilities for some of these variables could result indirectly from their convariation with one of the other heritable variables was assessed. The independence of the heritability of the influence of these four factors was investigated with 110 identical and 102 fraternal same-sex and 53 fraternal mixed-sex adult twin pairs who were paid to maintain 7-d food intake diaries. From the diary reports, the meal sizes were calculated and subjected to multiple regression analysis using the estimated before-meal stomach contents, the reported number of other people present, the subjective hunger ratings, and the time of day of the meal as predictors. Linear structural modeling was applied to the beta coefficients from the multiple regression to investigate whether the heritability of the influences of these four variables was independent. Significant genetic effects were found for the beta coefficients for all four variables, indicating that the heritability of their relationship with intake is to some extent heritable. These results suggest that the influences of multiple factors on intake are influenced by the genes and become part of the total package of genetically determined physiologic, sociocultural, and psychological processes that regulate energy balance.

Day-to-day ionospheric variability due to lower atmosphere perturbations

NASA Astrophysics Data System (ADS)

Liu, H.; Yudin, V. A.; Roble, R. G.

2013-12-01

Ionospheric day-to-day variability is a ubiquitous feature, even in the absence of appreciable geomagnetic activities. Although meteorological perturbations have been recognized as an important source of the variability, it is not well represented in previous modeling studies, and the mechanism is not well understood. This study demonstrates that TIME-GCM (Thermosphere-Ionosphere-Mesosphere-Electrodynamics General Circulation Model) constrained in the stratosphere and mesosphere by the hourly Whole Atmosphere Community Climate Model (WACCM) simulations is capable of reproducing observed features of day-to-day variability in the thermosphere-ionosphere. Realistic weather patterns in the lower atmosphere in WACCM was specified by Modern Era Retrospective reanalysis for Research and Application (MERRA). The day-to-day variations in mean zonal wind, migrating and non-migrating tides in the thermosphere, vertical and zonal ExB drifts, and ionosphere F2 layer peak electron density (NmF2) are examined. The standard deviations of the drifts and NmF2 display local time and longitudinal dependence that compare favorably with observations. Their magnitudes are 50% or more of those from observations. The day-to-day thermosphere and ionosphere variability in the model is primarily caused by the perturbations originated in lower atmosphere, since the model simulation is under constant solar minimum and low geomagnetic conditions.

Methane Seeps in the Gulf of Mexico: repeat acoustic surveying shows highly temporally and spatially variable venting

NASA Astrophysics Data System (ADS)

Beaumont, B. C.; Raineault, N.

2016-02-01

Scientists have recognized that natural seeps account for a large amount of methane emissions. Despite their widespread occurrence in areas like the Gulf of Mexico, little is known about the temporal variability and site-scale spatial variability of venting over time. We used repeat acoustic surveys to compare multiple days of seep activity and determine the changes in the locus of methane emission and plume height. The Sleeping Dragon site was surveyed with an EM302 multibeam sonar on three consecutive days in 2014 and 4 days within one week in 2015. The data revealed three distinctive plume regions. The locus of venting varied by 10-60 meters at each site. The plume that exhibited the least spatial variability in venting, was also the most temporally variable. This seep was present in one-third of survey dates in 2014 and three quarters of survey dates in 2015, showing high day-to-day variability. The plume height was very consistent for this plume, whereas the other plumes were more consistent temporally, but varied in maximum plume height detection by 25-85 m. The single locus of emission at the site that had high day-to-day variability may be due to a single conduit for methane release, which is sometimes closed off by carbonate or clathrate hydrate formation. In addition to day-to-day temporal variability, the locus of emission at one site was observed to shift from a point-source in 2014 to a diffuse source in 2015 at a nearby location. ROV observations showed that one of the seep sites that closed off temporarily, experienced an explosive breakthrough of gas, releasing confined methane and blowing out rock. The mechanism that causes on/off behavior of certain plumes, combined with the spatial variability of the locus of methane release shown in this study may point to carbonate or hydrate formation in the seep plumbing system and should be further investigated.

Intraseasonal-to-semiannual variability of sea-surface height in the eastern, equatorial Indian Ocean and southern Bay of Bengal

NASA Astrophysics Data System (ADS)

Cheng, X.; McCreary, J. P., Jr.; Qiu, B.; Yu, Z.; DU, Y.

2016-12-01

Intraseasonal-to-semiannual variability of sea-surface height (SSH) in the eastern, equatorial Indian Ocean (EEIO) and southern Bay of Bengal (BoB) is investigated using altimetric data, and solutions to 1½-layer (first-baroclinic-mode) and linear, continuously stratified (LCS; multi-baroclinic-mode) models. The amplitude and dominant period of SSH variability differ regionally. Large-amplitude variability is found along the west coast of Sumatra, in a zonal band across the BoB centered along 5°N, east of Sri Lanka, and in the northwestern BoB. Along the Sumatran west coast, SSH variability peaks at 30-60 days, 90 days, and 180 days. Along 5°N and east of Sri Lanka, 30-60-day variability is dominant. Sensitivity experiments using a nonlinear version of the 1½-layer model forced by realistic winds reproduce the observed patterns of intraseasonal variability in the southern BoB. At 30-60 days, the solutions show that eddies (nonlinear Rossby waves) propagating from the east, rather than local wind forcing, account for most of the variance east of Sri Lanka; furthermore, they demonstrate that the variance is significantly enhance by the nonlinear transfer of 90-120-day energy into the intraseasonal band. The LCS solutions show that the first two baroclinic modes explain most of the SSH variance at 90-180 days. The second-baroclinic-mode dominates the SSH variance at 180 days, a consequence of basin resonance and strong wind forcing.

Effect of carprofen on hemostatic variables in dogs.

PubMed

Hickford, F H; Barr, S C; Erb, H N

2001-10-01

To evaluate the effect of carprofen on hemostatic variables in clinically normal dogs. 12 clinically normal Labrador Retrievers. 10 dogs (6 females, 4 males) received carprofen (2.2 mg/kg of body weight, PO, q 12 h) for 5 days. Two dogs (untreated control group; 1 female, 1 male) did not receive carprofen. Hemostatic variables (platelet count, activated partial thromboplastin time, prothrombin time, fibrinogen, platelet aggregation, and bleeding time) were assessed for all dogs prior to treatment, on day 5 of treatment, and 2 and 7 days after discontinuation of the drug (days 7 and 12). Serum biochemical variables and Hct were assessed prior to treatment and on days 5 and 12. In dogs receiving carprofen, platelet aggregation was significantly decreased, and onset of aggregation was significantly delayed on days 5, 7, and 12, compared with pretreatment values. Activated partial thromboplastin time was significantly increased on days 5, 7, and 12 over pretreatment values in treated dogs, but values remained within reference ranges. Significant differences were not detected in buccal mucosal bleeding time, other serum biochemical and hemostatic variables, or Hct, compared with pretreatment values and the internal control group. Administration of carprofen for 5 days causes minor but not clinically important alterations in hemostatic and serum biochemical variables in clinically normal Labrador Retrievers. Carprofen is commonly used to treat osteoarthritis and chronic pain in dogs, but prior to this study, its effect on platelet aggregation and hemostatic variables was unknown.

The NP Draconii Multiple Star System

NASA Astrophysics Data System (ADS)

Castelaz, Michael W.; Barker, Thurburn; McNaughton, Abby; Robertson, Rachel; Smith, Matt

2016-01-01

Otero and Dubovsky used the ASAS-3 (Pojmanski 2002), Hipparcos (Perryman et al 1997) and Northern Sky Variability Survey (NSVS; Wozniak et al 2004) databases to determine elements for 80 eclipsing binaries. NP Draconii (NSV 22984) was identified by Otero and Dubovsky (IBVS Number 5557, 2004) as a possible Algol type variable with an ephemeris of HJD Min I = 2448604.780+3.10886E days based on 84 observations over 326 days with about 2 to 4 observations on any one night. We decided to further refine the ephemeris and observe NP Dra in VRI filters, with the goal of determining the elements of the system.NP Dra is a V = 9.0 system located at J2000 = 17h 35m 16s and +55d 00' 12". We observed NP Dra August 2, 3 and September 15, 16, 17, 18, and 19 2015 UT using the Pisgah Astronomical Research Institute 0.4-m telescope in V, R, and I with 20 second exposure times in each filter. Observations in each filter were repeated about every 3 minutes each night of observing.From our light curves we determined the period using the Date Compensated Discrete Fourier Transform function (Ferraz-Mello 1981) which is part of the open source code VSTAR (AAVSO). The period derived from the observations is 2.2755 days. Superimposed on this period is another period of 0.6398 days. We will present the V, R, and I light curves, period determination and implication

A Q-GERT Model for Determining the Maintenance Crew Size for the SAC command Post Upgrade

DTIC Science & Technology

1983-12-01

time that an equiprment fails. DAY3 A real variable corresponding to the day that an LRU is removed from the equipment. DAY4 A real variable...variable corresponding to the time that an LRU is repaired. TIM5 A real variable corresponaing to Lhe time that an equipment returns to service. TNOW...The current time . UF(IFN) User function IFN. UN(I) A sample from the uniform distri- bution defined by parameter set I. YIlN1 A real variable

Increased plasma selenium is associated with better outcomes in children with systemic inflammation.

PubMed

Leite, Heitor Pons; Nogueira, Paulo Cesar Koch; Iglesias, Simone Brasil de Oliveira; de Oliveira, Susyane Vieira; Sarni, Roseli Oselka Saccardo

2015-03-01

The aim of this study was to assess the effects of changes in plasma selenium on the outcome of critically ill children. Plasma selenium was prospectively measured in 99 children with acute systemic inflammation. The exposure variables were selenium level on admission and on day 5 of stay in the intensive care unit (ICU) and the difference in selenium concentrations between day 5 post-admission and the ICU admission (delta selenium). Selenium was given only as part of enteral diets. Age, malnutrition, red cell glutathione peroxidase-1 activity, serum C-reactive protein, Pediatric Index of Mortality 2, and Pediatric Logistic Organ Dysfunction scores were analyzed as covariates. The outcome variables were ventilator-free days, ICU-free days, and 28-d mortality. Plasma selenium concentrations increased from admission (median 23.4 μg/L, interquartile range 12.0-30.8) to day 5 (median 25.1 μg/L, interquartile range 16.0-39.0; P = 0.018). After adjustment for confounding factors, a delta selenium increase of 10 μg/L was associated with reductions in ventilator days (1.3 d; 95% confidence interval [CI], 0.2-2.3; P = 0.017) and ICU days (1.4 d; 95% CI, 0.5-2.3; P < 0.01). Delta selenium >0 was associated with decreased 28-d mortality on a univariate model (odds ratio, 0.67; 95% CI, 0.46-0.97; P = 0.036). The mean daily selenium intake (6.82 μg; range 0-48.66 μg) was correlated with the increase in selenium concentrations on day 5. An increase in plasma selenium is independently associated with shorter times of ventilation and ICU stay in children with systemic inflammation. These findings raise the hypothesis that selenium supplementation could be beneficial in children with critical illnesses. Copyright © 2015 Elsevier Inc. All rights reserved.

Identification of Active Galactic Nuclei through HST optical variability in the GOODS South field

NASA Astrophysics Data System (ADS)

Pouliasis, Ektoras; Georgantopoulos; Bonanos, A.; HCV Team

2016-08-01

This work aims to identify AGN in the GOODS South deep field through optical variability. This method can easily identify low-luminosity AGN. In particular, we use images in the z-band obtained from the Hubble Space Telescope with the ACS/WFC camera over 5 epochs separated by ~45 days. Aperture photometry has been performed using SExtractor to extract the lightcurves. Several variability indices, such as the median absolute deviation, excess variance, and sigma were applied to automatically identify the variable sources. After removing artifacts, stars and supernovae from the variable selected sample and keeping only those sources with known photometric or spectroscopic redshift, the optical variability was compared to variability in other wavelengths (X-rays, mid-IR, radio). This multi-wavelength study provides important constraints on the structure and the properties of the AGN and their relation to their hosts. This work is a part of the validation of the Hubble Catalog of Variables (HCV) project, which has been launched at the National Observatory of Athens by ESA, and aims to identify all sources (pointlike and extended) showing variability, based on the Hubble Source Catalog (HSC, Whitmore et al. 2015). The HSC version 1 was released in February 2015 and includes 80 million sources imaged with the WFPC2, ACS/WFC, WFC3/UVIS and WFC3/IR cameras.

Components of day-to-day variability of cerebral perfusion measurements - Analysis of phase contrast mapping magnetic resonance imaging measurements in healthy volunteers.

PubMed

Ismaili, Abd R A; Vestergaard, Mark B; Hansen, Adam E; Larsson, Henrik B W; Johannesen, Helle H; Law, Ian; Henriksen, Otto M

2018-01-01

The aim of the study was to investigate the components of day-to-day variability of repeated phase contrast mapping (PCM) magnetic resonance imaging measurements of global cerebral blood flow (gCBF). Two dataset were analyzed. In Dataset 1 duplicated PCM measurements of total brain flow were performed in 11 healthy young volunteers on two separate days applying a strictly standardized setup. For comparison PCM measurements obtained from a previously published study (Dataset 2) were analyzed in order to assess long-term variability in an aged population in a less strictly controlled setup. Global CBF was calculated by normalizing total brain flow to brain volume. On each day measurements of hemoglobin, caffeine and glucose were obtained. Linear mixed models were applied to estimate coefficients of variation (CV) of total (CVt), between-subject (CVb), within-subject day-to-day (CVw), and intra-session residual variability (CVr). In Dataset 1 CVt, CVb, CVw and CVr were estimated to be 11%, 9.4%, 4% and 4.2%, respectively, and to 8.8%, 7.2%, 2.7% and 4.3%, respectively, when adjusting for hemoglobin and plasma caffeine. In Dataset 2 CVt, CVb and CVw were estimated to be 25.4%, 19.2%, and 15.0%, respectively, and decreased to 16.6%, 8.2% and 12.5%, respectively, when adjusting for the same covariates. Our results suggest that short-term day-to-day variability of gCBF is relatively low compared to between-subject variability when studied in standardized conditions, whereas long-term variability in an aged population appears to be much larger when studied in less a standardized setup. The results further showed that from 20% to 35% of the total variability in gCBF can be attributed to the effects of hemoglobin and caffeine.

Body temperature variability (Part 2): masking influences of body temperature variability and a review of body temperature variability in disease.

PubMed

Kelly, Gregory S

2007-03-01

This is the second of a two-part review on body temperature variability. Part 1 discussed historical and modern findings on average body temperatures. It also discussed endogenous sources of temperature variability, including variations caused by site of measurement; circadian, menstrual, and annual biological rhythms; fitness; and aging. Part 2 reviews the effects of exogenous masking agents - external factors in the environment, diet, or lifestyle that can be a significant source of body temperature variability. Body temperature variability findings in disease states are also reviewed.

Patterns of postnatal weight changes in infants with very low and extremely low birth weights.

PubMed

Smith, S L; Kirchhoff, K T; Chan, G M; Squire, S J

1994-01-01

To describe (1) short-term postnatal weight loss and gain patterns in infants with very low and extremely low birth weights and (2) the variables that may affect these weight change patterns. Descriptive, retrospective review. University hospital in the intermountain western United States. Sixty-two charts of infants admitted to a university neonatal intensive care unit from July 1990 through November 1992 were reviewed. Infants who weighed 1000 grams or less were categorized as extremely low birth weight (ELBW) and infants weighing 1001 to 1500 grams were categorized as very low birth weight (VLBW). Each group was comprised of 31 infants. Fifty percent of the sample were male, and 50% were female. Eighty-five percent of the sample were Anglo-American, and 15% were non-Anglo-American. Data were collected on a three-part data collection tool and included demographic and treatment variables. A significant difference was found in the maximum percent weight lost between the two groups, with the ELBW group losing a mean of 14.77% of birth weight and the VLBW group losing a mean of 11.35% of birth weight (t = 2.45, p < 0.05). The day the infants reached their nadir weight was significantly different between the two groups. The ELBW group reached their nadir on day of life 7, and the VLBW group reached their nadir on day of life 6 (t = 2.00, p < 0.05). No significant difference was noted in the time to return to birth weight between the two groups, with a mean of 15 days to return to birth weight. Factors associated with postnatal weight changes were intraventricular hemorrhage, use of diuretics and steroids, day of life when nadir weight occurred, and maximum percent of weight lost. Many of the independent variables were significantly interrelated to each other (r = -0.90 to r = 0.91, p < 0.01 to p < 0.001). However, only the variables that correlated with time to return to birth weight were entered into the regression analysis. These variables included number of days diuretics were given before return to birth weight, maximum percent of weight lost, and day of life the infants reached their nadir weight. Number of days diuretics were given before return to birth weight correlated significantly with time to return to birth weight (r = 0.77, F = 26.66, p < 0.0001) although maximum percent of weight lost and day of life the infants reached their nadir weight had a minimal effect. Further research into the effects of diuretic therapy on weight changes in this population of infants may lead to interventions to minimize the negative effects of diuretics on return to birth weight. In addition, the older growth charts may not be applicable to this population of infants. Generation of new growth charts that provide growth curves based on these data could be useful in developing nutritional therapies that would promote growth and possibly decrease the length of hospital stay for these infants.

Synoptic and climatological aspects of extra-tropical cyclones

NASA Astrophysics Data System (ADS)

Leckebusch, G. C.

2010-09-01

Mid-latitude cyclones are highly complex dynamical features embedded in the general atmospheric circulation of the extra-tropics. Although the basic mechanisms leading to the formation of cyclones are commonly understood, the specific conditions and physical reasons triggering extreme, partly explosive development, are still under investigation. This includes also the identification of processes which might modulate the frequency and intensity of cyclone systems on time scales from days to centennials. This overview presentation will thus focus on three main topics: Firstly, the dynamic-synoptic structures of cyclones, the possibility to objectively identify cyclones and wind storms, and actual statistical properties of cyclone occurrence under recent climate conditions are addressed. In a second part, aspects of the interannual variability and its causing mechanisms are related to the seasonal predictability of extreme cyclones producing severe storm events. Extending the time frame will mean to deduce information on decadal or even centennial time periods. Thus, actual work to decadal as well as climatological variability and changes will be presented. In the last part of the talk focus will be laid on potential socio-economical impacts of changed cyclone occurrence. By means of global and regional climate modeling, future damages in terms of insured losses will be investigated and measures of uncertainty estimated from a multi-model ensemble analysis will be presented.

Enhanced future variability during India's rainy season

NASA Astrophysics Data System (ADS)

Menon, Arathy; Levermann, Anders; Schewe, Jacob

2013-04-01

The Indian summer monsoon shapes the livelihood of a large share of the world's population. About 80% of annual precipitation over India occurs during the monsoon season from June through September. Next to its seasonal mean rainfall the day-to-day variability is crucial for the risk of flooding, national water supply and agricultural productivity. Here we show that the latest ensemble of climate model simulations, prepared for the IPCC's AR-5, consistently projects significant increases in day-to-day rainfall variability under unmitigated climate change. While all models show an increase in day-to-day variability, some models are more realistic in capturing the observed seasonal mean rainfall over India than others. While no model's monsoon rainfall exceeds the observed value by more than two standard deviations, half of the models simulate a significantly weaker monsoon than observed. The relative increase in day-to-day variability by the year 2100 ranges from 15% to 48% under the strongest scenario (RCP-8.5), in the ten models which capture seasonal mean rainfall closest to observations. The variability increase per degree of global warming is independent of the scenario in most models, and is 8% +/- 4% per K on average. This consistent projection across 20 comprehensive climate models provides confidence in the results and suggests the necessity of profound adaptation measures in the case of unmitigated climate change.

The 27-day versus 13.5-day variations in the solar Lyman-alpha radiation and the radio wave absorption in the lower ionosphere over Europe

NASA Technical Reports Server (NTRS)

Delamorena, B. A.; Lastovicka, Jan; Rapoport, Z. TS.; Alberca, L.

1989-01-01

In order to clarify the question of solar periods in absorption, the pattern was studied of the solar Lyman-alpha radiation (the principal ionizing agent of the lower ionosphere) and of the radio wave absorption at five widely spaced places in Europe. When the solar Lyman-alpha flux variability is very well developed, then it dominates in the lower ionospheric variability. The most pronounced Lyman-alpha variation on time scale day-month is the solar rotation variation (about 27 days). When the Lyman-alpha variability is developed rather poorly, as it is typical for periods dominated by the 13.5 day variability, then the lower ionospheric variability appears to be dominated by variations of meteorological origin. The conclusions hold for all five widely spaced placed in Europe.

Prognostic significance of day-by-day variability of home blood pressure on progression to macroalbuminuria in patients with diabetes.

PubMed

Ushigome, Emi; Matsumoto, Shinobu; Oyabu, Chikako; Kitagawa, Noriyuki; Tanaka, Toru; Hasegawa, Goji; Ohnishi, Masayoshi; Tsunoda, Sei; Ushigome, Hidetaka; Yokota, Isao; Nakamura, Naoto; Oda, Yohei; Asano, Mai; Tanaka, Muhei; Yamazaki, Masahiro; Fukui, Michiaki

2018-05-01

Previously, we have shown in cross-sectional analysis of patients with type 2 diabetes mellitus that the presence of diabetic nephropathy is associated with increased home blood pressure (HBP) variability. We now examine the prognostic significance of HBP variability in substantially the same cohort. We performed a prospective cohort study of type 2 diabetes patients. We analyzed 714 patients. Major exclusion criteria are missing data of urinary albumin excretion and newly prescribed or stopped renin-angiotensin system inhibitors during 2-year follow-up. Patients were instructed to perform triplicate morning and evening HBP measurements for 14 consecutive days. We computed day-by-day HBP variability as within-patient standard deviation (SD) and coefficient of variation (CV) of measurements. During the follow-up period of 2 years, 23 patients progressed to macroalbuminuria. The changing risk of progression to macroalbuminuria with increasing day-by-day variability of morning SBP was better depicted using smoothing spline analyses. Patients with greater SD of morning SBP tended to significantly progress to macroalbuminuria [odds ratio: 5.24 (95% confidence interval: 2.10-13.03; P > 0.001)]. Patients with greater CV of morning SBP also tended to significantly progress to macroalbuminuria [odds ratio: 3.36 (95% confidence interval: 1.39-8.12; P = 0.007)]. Day-by-day variability of morning SBP was proven as an independent predictor for progression to macroalbuminuria in patients with type 2 diabetes.

Sq Currents and Neutral Winds

NASA Astrophysics Data System (ADS)

Yamazaki, Y.

2015-12-01

The relationship between ionospheric dynamo currents and neutral winds is examined using the Thermosphere Ionosphere Mesosphere Electrodynamic General Circulation Model (TIME-GCM). The simulation is run for May and June 2009 with variable neutral winds but with constant solar and magnetospheric energy inputs, which ensures that day-to-day changes in the solar quiet (Sq) current system arise only from lower atmospheric forcing. The intensity and focus position of the simulated Sq current system exhibit large day-to-day variability, as is also seen in ground magnetometer data. We show how the day-to-day variation of the Sq current system relate to variable winds at various altitudes, latitudes, and longitudes.

Estimating Water Fluxes Across the Sediment-Water Interface in the Lower Merced River, California

USGS Publications Warehouse

Zamora, Celia

2008-01-01

The lower Merced River Basin was chosen by the U.S. Geological Survey?s (USGS) National Water Quality Assessment Program (NAWQA) to be included in a national study on how hydrological processes and agricultural practices interact to affect the transport and fate of agricultural chemicals. As part of this effort, surface-water?ground-water (sw?gw) interactions were studied in an instrumented 100-m reach on the lower Merced River. This study focused on estimating vertical rates of exchange across the sediment?water interface by direct measurement using seepage meters and by using temperature as a tracer coupled with numerical modeling. Temperature loggers and pressure transducers were placed in monitoring wells within the streambed and in the river to continuously monitor temperature and hydraulic head every 15 minutes from March 2004 to October 2005. One-dimensional modeling of heat and water flow was used to interpret the temperature and head observations and deduce the sw?gw fluxes using the USGS numerical model, VS2DH, which simulates variably saturated water flow and solves the energy transport equation. Results of the modeling effort indicate that the Merced River at the study reach is generally a slightly gaining stream with small head differences (cm) between the surface water and ground water, with flow reversals occurring during high streamflow events. The average vertical flux across the sediment?water interface was 0.4?2.2 cm/day, and the range of hydraulic conductivities was 1?10 m/day. Seepage meters generally failed to provide accurate data in this high-energy system because of slow seepage rates and a moving streambed resulting in scour or burial of the seepage meters. Estimates of streambed hydraulic conductivity were also made using grain-size analysis and slug tests. Estimated hydraulic conductivity for the upstream transect determined using slug tests ranged from 40 to 250 m/day, whereas the downstream transect ranged from 10 to 100 m/day. The range in variability was a result of position along each transect. A relative percent difference was used to describe the variability in estimates of hydraulic conductivity by grain-size analysis and slug test. Variability in applied methods at the upstream transect ranged from 0 to 9 percent, whereas the downstream transect showed greater variability, with a range of 80 to 133 percent.

Anatomy of the AGN in NGC 5548. VII. Swift study of obscuration and broadband continuum variability

NASA Astrophysics Data System (ADS)

Mehdipour, M.; Kaastra, J. S.; Kriss, G. A.; Cappi, M.; Petrucci, P.-O.; De Marco, B.; Ponti, G.; Steenbrugge, K. C.; Behar, E.; Bianchi, S.; Branduardi-Raymont, G.; Costantini, E.; Ebrero, J.; Di Gesu, L.; Matt, G.; Paltani, S.; Peterson, B. M.; Ursini, F.; Whewell, M.

2016-04-01

We present our investigation into the long-term variability of the X-ray obscuration and optical-UV-X-ray continuum in the Seyfert 1 galaxy NGC 5548. In 2013 and 2014, the Swift observatory monitored NGC 5548 on average every day or two, with archival observations reaching back to 2005, totalling about 670 ks of observing time. Both broadband spectral modelling and temporal rms variability analysis are applied to the Swift data. We disentangle the variability caused by absorption, due to an obscuring weakly-ionised outflow near the disk, from variability of the intrinsic continuum components (the soft X-ray excess and the power law) originating in the disk and its associated coronae. The spectral model that we apply to this extensive Swift data is the global model that we derived for NGC 5548 from analysis of the stacked spectra from our multi-satellite campaign of 2013 (including XMM-Newton, NuSTAR, and HST). The results of our Swift study show that changes in the covering fraction of the obscurer is the primary and dominant cause of variability in the soft X-ray band on timescales of 10 days to ~5 months. The obscuring covering fraction of the X-ray source is found to range between 0.7 and nearly 1.0. The contribution of the soft excess component to the X-ray variability is often much less than that of the obscurer, but it becomes comparable when the optical-UV continuum flares up. We find that the soft excess is consistent with being the high-energy tail of the optical-UV continuum and can be explained by warm Comptonisation: up-scattering of the disk seed photons in a warm, optically thick corona as part of the inner disk. To this date, the Swift monitoring of NGC 5548 shows that the obscurer has been continuously present in our line of sight for at least 4 years (since at least February 2012).

Video raster stereography back shape reconstruction: a reliability study for sagittal, frontal, and transversal plane parameters.

PubMed

Schroeder, J; Reer, R; Braumann, K M

2015-02-01

As reliability of raster stereography was proved only for sagittal plane parameters with repeated measures on the same day, the present study was aiming at investigating variability and reliability of back shape reconstruction for all dimensions (sagittal, frontal, transversal) and for different intervals. For a sample of 20 healthy volunteers, intra-individual variability (SEM and CV%) and reliability (ICC ± 95% CI) were proved for sagittal (thoracic kyphosis, lumbar lordosis, pelvis tilt angle, and trunk inclination), frontal (pelvis torsion, pelvis and trunk imbalance, vertebral side deviation, and scoliosis angle), transversal (vertebral rotation), and functional (hyperextension) spine shape reconstruction parameters for different test-retest intervals (on the same day, between-day, between-week) by means of video raster stereography. Reliability was high for the sagittal plane (pelvis tilt, kyphosis and lordosis angle, and trunk inclination: ICC > 0.90), and good to high for lumbar mobility (0.86 < ICC < 0.97). Apart from sagittal plane spinal alignment, there was a lack of certainty for a high reproducibility indicated by wider ICC confidence intervals. So, reliability was fair to high for vertebral side deviation and the scoliosis angle (0.71 < ICC < 0.95), and poor to good for vertebral rotation values as well as for frontal plane upper body and pelvis position parameters (0.65 < ICC < 0.92). Coefficients for the between-day and between-week interval were a little lower than for repeated measures on the same day. Variability (SEM) was less than 1.5° or 1.5 mm, except for trunk inclination. Relative variability (CV) was greater in global trunk position and pelvis parameters (35-98%) than in scoliosis (14-20%) or sagittal sway parameters (4-8 %). Although we found a lower reproducibility for the frontal plane, raster stereography is considered to be a reliable method for the non-invasive, three-dimensional assessment of spinal alignment in normal non-scoliotic individuals in the sagittal plane and partly for scoliosis parameters, which fulfils scientific as well as practical recommendations for spine shape screening and monitoring, but cross-sectional or follow-up effect analyses should take into account the degree of reliability differing in various spine shape parameters. Further investigations should be conducted to analyse reliability in scoliosis patients with differing spinal deformities.

Influence of lunar cycles on growth of Ashwagandha (Withania somnifera [L.] Dunal).

PubMed

Tavhare, Swagata D; Nishteswar, K; Shukla, Vinay J

2015-01-01

Ayurvedic classics have advocated to collect the medicinal plants according to part used and seasons in order to get desired pharmacological action and therapeutic benefits. The logic behind this principle is being validated by recent researches. To analyze the influence of lunar cycles on growth of Ashwagandha in Shishira and Greeshma Ritu (winter and summer season). Fourteen small crops of Ashwagandha of average size 10 cm were collected on October 7, 2013, from institute campus and then replantation was done at Charaka Herbal Garden, Gujarat Ayurved University, Jamnagar in an area of 60 cm × 60 cm (l × b). No fertilizers or pesticides were used. The plants were watered daily and plants were uprooted as per lunar cycles for analysis. Eight samples were collected and observed during Shishira and Greeshma season on Pournima (full moon) and Amavasya (new moon) days. The measurements were taken thrice and average values were taken into consideration for study purpose. The variations in morphological characteristics such as length, breadth, weight, and number of roots and twigs were studied through statistical procedure of principle component analysis, which makes interpretation of all possible related variables. Root weight (RW), pith diameter (PD) and internodal distance (ID) were found to be increased on full moon days as compared to new moon days. The maximum RW was observed during Greeshma Aashadha Pournima. The study has shown a definite influence of lunar cycles on the growth of the plant parts assessed by RW, PD, and ID that have found to be increased on full moon days as compared to new moon days.

Long-term variability of dust events in Iceland (1949-2011)

NASA Astrophysics Data System (ADS)

Dagsson-Waldhauserova, P.; Arnalds, O.; Olafsson, H.

2014-12-01

The long-term frequency of atmospheric dust observations was investigated for the southern part of Iceland and interpreted together with earlier results obtained from northeastern (NE) Iceland (Dagsson-Waldhauserova et al., 2013). In total, over 34 dust days per year on average occurred in Iceland based on conventionally used synoptic codes for dust observations. However, frequent volcanic eruptions, with the re-suspension of volcanic materials and dust haze, increased the number of dust events fourfold (135 dust days annually). The position of the Icelandic Low determined whether dust events occurred in the NE (16.4 dust days annually) or in the southern (S) part of Iceland (about 18 dust days annually). The decade with the most frequent dust days in S Iceland was the 1960s, but the 2000s in NE Iceland. A total of 32 severe dust storms (visibility < 500 m) were observed in Iceland with the highest frequency of events during the 2000s in S Iceland. The Arctic dust events (NE Iceland) were typically warm, occurring during summer/autumn (May-September) and during mild southwesterly winds, while the subarctic dust events (S Iceland) were mainly cold, occurring during winter/spring (March-May) and during strong northeasterly winds. About half of the dust events in S Iceland occurred in winter or at sub-zero temperatures. A good correlation was found between particulate matter (PM10) concentrations and visibility during dust observations at the stations Vík and Stórhöfði. This study shows that Iceland is among the dustiest areas of the world and that dust is emitted year-round.

Using robust principal component analysis to alleviate day-to-day variability in EEG based emotion classification.

PubMed

Ping-Keng Jao; Yuan-Pin Lin; Yi-Hsuan Yang; Tzyy-Ping Jung

2015-08-01

An emerging challenge for emotion classification using electroencephalography (EEG) is how to effectively alleviate day-to-day variability in raw data. This study employed the robust principal component analysis (RPCA) to address the problem with a posed hypothesis that background or emotion-irrelevant EEG perturbations lead to certain variability across days and somehow submerge emotion-related EEG dynamics. The empirical results of this study evidently validated our hypothesis and demonstrated the RPCA's feasibility through the analysis of a five-day dataset of 12 subjects. The RPCA allowed tackling the sparse emotion-relevant EEG dynamics from the accompanied background perturbations across days. Sequentially, leveraging the RPCA-purified EEG trials from more days appeared to improve the emotion-classification performance steadily, which was not found in the case using the raw EEG features. Therefore, incorporating the RPCA with existing emotion-aware machine-learning frameworks on a longitudinal dataset of each individual may shed light on the development of a robust affective brain-computer interface (ABCI) that can alleviate ecological inter-day variability.

Analysis and Synthesis of Load Forecasting Data for Renewable Integration Studies: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steckler, N.; Florita, A.; Zhang, J.

2013-11-01

As renewable energy constitutes greater portions of the generation fleet, the importance of modeling uncertainty as part of integration studies also increases. In pursuit of optimal system operations, it is important to capture not only the definitive behavior of power plants, but also the risks associated with systemwide interactions. This research examines the dependence of load forecast errors on external predictor variables such as temperature, day type, and time of day. The analysis was utilized to create statistically relevant instances of sequential load forecasts with only a time series of historic, measured load available. The creation of such load forecastsmore » relies on Bayesian techniques for informing and updating the model, thus providing a basis for networked and adaptive load forecast models in future operational applications.« less

New SX Phoenicis Variables in the Globular Cluster NGC 4833

NASA Astrophysics Data System (ADS)

Darragh, A. N.; Murphy, B. W.

2012-07-01

We report the discovery of 6 SX Phoenicis stars in the southern globular cluster NGC 4833. Images were obtained from January through June 2011 with the Southeastern Association for Research in Astronomy 0.6 meter telescope located at Cerro Tololo Interamerican Observatory. The ISIS image subtraction method was used to search for variable stars in the cluster. We confirmed 17 previously cataloged variables and have identified 10 new variables. Of the total number of confirmed variables in our 10×10 arcmin^2 field, we classified 10 RRab variables, with a mean period of 0.69591 days, 7 RRc, with a mean period of 0.39555 days, 2 possible RRe variables with a mean period of 0.30950 days, a W Ursae Majoris contact binary, an Algol-type binary, and the 6 SX Phoenicis stars with a mean period of 0.05847 days. The periods, relative numbers of RRab and RRc variables, and Bailey diagram are indicative of the cluster being of the Oosterhoff type II. We present the phased-light curves, periods of previously known variables and the periods and classifications of the newly discovered variables, and their location on the color-magnitude diagram.

Day-to-Day Variability of Postural Sway and Its Association With Cognitive Function in Older Adults: A Pilot Study

PubMed Central

Leach, Julia M.; Mancini, Martina; Kaye, Jeffrey A.; Hayes, Tamara L.; Horak, Fay B.

2018-01-01

Introduction: Increased variability in motor function has been observed during the initial stages of cognitive decline. However, the natural variability of postural control, as well as its association with cognitive status and decline, remains unknown. The objective of this pilot study was to characterize the day-to-day variability in postural sway in non-demented older adults. We hypothesized that older adults with a lower cognitive status would have higher day-to-day variability in postural sway. Materials and Methods: A Nintendo Wii balance board (WBB) was used to quantify postural sway in the home twice daily for 30 days in 20 non-demented, community-dwelling older adults: once under a single-task condition and once under a dual-task condition (using a daily word search task administered via a Nook tablet). Mean sway distance, velocity, area, centroidal frequency and frequency dispersion were derived from the center of pressure data acquired from the WBB. Results: Linear relationships were observed between the day-to-day variability in postural sway and cognitive status (indexed by cognitive global z-scores). More variability in time-domain postural sway (sway distance and area) and less variability in frequency-domain postural sway (centroidal sway frequency) were associated with a lower cognitive status under both the single- and dual-task conditions. Additionally, lower cognitive performance rates on the daily word search task were related to a lower cognitive status. Discussion: This small pilot study conducted on a short time scale motivates large-scale implementations over more extended time periods. Tracking longitudinal changes in postural sway may further our understanding of early-stage postural decline and its association with cognitive decline and, in turn, may aid in the early detection of dementia during preclinical stages when the utility of disease-modifying therapies would be greatest. PMID:29780319

Day-to-Day Variability of Postural Sway and Its Association With Cognitive Function in Older Adults: A Pilot Study.

PubMed

Leach, Julia M; Mancini, Martina; Kaye, Jeffrey A; Hayes, Tamara L; Horak, Fay B

2018-01-01

Introduction : Increased variability in motor function has been observed during the initial stages of cognitive decline. However, the natural variability of postural control, as well as its association with cognitive status and decline, remains unknown. The objective of this pilot study was to characterize the day-to-day variability in postural sway in non-demented older adults. We hypothesized that older adults with a lower cognitive status would have higher day-to-day variability in postural sway. Materials and Methods : A Nintendo Wii balance board (WBB) was used to quantify postural sway in the home twice daily for 30 days in 20 non-demented, community-dwelling older adults: once under a single-task condition and once under a dual-task condition (using a daily word search task administered via a Nook tablet). Mean sway distance, velocity, area, centroidal frequency and frequency dispersion were derived from the center of pressure data acquired from the WBB. Results : Linear relationships were observed between the day-to-day variability in postural sway and cognitive status (indexed by cognitive global z-scores). More variability in time-domain postural sway (sway distance and area) and less variability in frequency-domain postural sway (centroidal sway frequency) were associated with a lower cognitive status under both the single- and dual-task conditions. Additionally, lower cognitive performance rates on the daily word search task were related to a lower cognitive status. Discussion : This small pilot study conducted on a short time scale motivates large-scale implementations over more extended time periods. Tracking longitudinal changes in postural sway may further our understanding of early-stage postural decline and its association with cognitive decline and, in turn, may aid in the early detection of dementia during preclinical stages when the utility of disease-modifying therapies would be greatest.

Variable Sodium Absorption in a Low-extinction Type Ia Supernova

NASA Astrophysics Data System (ADS)

Simon, Joshua D.; Gal-Yam, Avishay; Gnat, Orly; Quimby, Robert M.; Ganeshalingam, Mohan; Silverman, Jeffrey M.; Blondin, Stephane; Li, Weidong; Filippenko, Alexei V.; Wheeler, J. Craig; Kirshner, Robert P.; Patat, Ferdinando; Nugent, Peter; Foley, Ryan J.; Vogt, Steven S.; Butler, R. Paul; Peek, Kathryn M. G.; Rosolowsky, Erik; Herczeg, Gregory J.; Sauer, Daniel N.; Mazzali, Paolo A.

2009-09-01

Recent observations have revealed that some Type Ia supernovae exhibit narrow, time-variable Na I D absorption features. The origin of the absorbing material is controversial, but it may suggest the presence of circumstellar gas in the progenitor system prior to the explosion, with significant implications for the nature of the supernova (SN) progenitors. We present the third detection of such variable absorption, based on six epochs of high-resolution spectroscopy of the Type Ia supernova SN 2007le from the Keck I Telescope and the Hobby-Eberly Telescope. The data span a time frame of approximately three months, from 5 days before maximum light to 90 days after maximum. We find that one component of the Na I D absorption lines strengthened significantly with time, indicating a total column density increase of ~2.5 × 1012 cm-2. The data limit the typical timescale for the variability to be more than 2 days but less than 10 days. The changes appear to be most prominent after maximum light rather than at earlier times when the ultraviolet flux from the SN peaks. As with SN 2006X, we detect no change in the Ca II H and K absorption lines over the same time period, rendering line-of-sight effects improbable and suggesting a circumstellar origin for the absorbing material. Unlike the previous two supernovae exhibiting variable absorption, SN 2007le is not highly reddened (E B - V = 0.27 mag), also pointing toward circumstellar rather than interstellar absorption. Photoionization calculations show that the data are consistent with a dense (107 cm-3) cloud or clouds of gas located ~0.1 pc (3 × 1017 cm) from the explosion. These results broadly support the single-degenerate scenario previously proposed to explain the variable absorption, with mass loss from a nondegenerate companion star responsible for providing the circumstellar gas. We also present possible evidence for narrow Hα emission associated with the SN, which will require deep imaging and spectroscopy at late times to confirm. Some of the data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and NASA. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. Based in part on observations obtained with the Hobby-Eberly Telescope, which is a joint project of the University of Texas at Austin, the Pennsylvania State University, Stanford University, Ludwig-Maximilians-Universität München, and Georg-August-Universität Göttingen.

Rainfall Variability, Adaptation through Irrigation, and Sustainable Management of Water Resources in India

NASA Astrophysics Data System (ADS)

Fishman, R.

2013-12-01

Most studies of the impact of climate change on agriculture account for shifts in temperature and total seasonal (or monthly) precipitation. However, climate change is also projected to increase intra-seasonal precipitation variability in many parts of the world. To provide first estimates of the potential impact, I paired daily rainfall and rice yield data during the period 1970-2004, from across India, where about a fifth of the world's rice is produced, and yields have always been highly dependent on the erratic monsoon rainfall. Multivariate regression models revealed that the number of rainless days during the wet season has a statistically robust negative impact on rice yields that exceeds that of total seasonal rainfall. Moreover, a simulation of climate change impacts found that the negative impact of the projected increase in the number of rainless days will trump the positive impact of the projected increase in total precipitation, and reverse the net precipitation effect on rice production from positive (+3%) to negative (-10%). The results also indicate that higher irrigation coverage is correlated with reduced sensitivity to rainfall variability, suggesting the expansion of irrigation can effectively adapt agriculture to these climate change impacts. However, taking into account limitations on water resource availability in India, I calculate that under current irrigation practices, sustainable use of water can mitigate less than a tenth of the impact.

Mechanisms of the 40-70 Day Variability in the Yucatan Channel Volume Transport

NASA Astrophysics Data System (ADS)

van Westen, René M.; Dijkstra, Henk A.; Klees, Roland; Riva, Riccardo E. M.; Slobbe, D. Cornelis; van der Boog, Carine G.; Katsman, Caroline A.; Candy, Adam S.; Pietrzak, Julie D.; Zijlema, Marcel; James, Rebecca K.; Bouma, Tjeerd J.

2018-02-01

The Yucatan Channel connects the Caribbean Sea with the Gulf of Mexico and is the main outflow region of the Caribbean Sea. Moorings in the Yucatan Channel show high-frequent variability in kinetic energy (50-100 days) and transport (20-40 days), but the physical mechanisms controlling this variability are poorly understood. In this study, we show that the short-term variability in the Yucatan Channel transport has an upstream origin and arises from processes in the North Brazil Current. To establish this connection, we use data from altimetry and model output from several high resolution global models. A significant 40-70 day variability is found in the sea surface height in the North Brazil Current retroflection region with a propagation toward the Lesser Antilles. The frequency of variability is generated by intrinsic processes associated with the shedding of eddies, rather than by atmospheric forcing. This sea surface height variability is able to pass the Lesser Antilles, it propagates westward with the background ocean flow in the Caribbean Sea and finally affects the variability in the Yucatan Channel volume transport.

Absenteeism and health-benefit costs among employees with MS.

PubMed

Brook, Richard A; Rajagopalan, Krithika; Kleinman, Nathan L; Melkonian, Arthur K

2009-06-01

The purpose of this analysis was to assess the differences in lost time and health-benefit costs (HBCs) among employees treated with disease modifying treatments (DMTs) for multiple sclerosis (MS). Employees with an MS diagnostic code (ICD-9 340.xx) and a DMT prescription claim (1/1/2001-6/30/2007) were identified from the HCMS Research Reference Database and assigned to DMT cohorts. The first prescription for the DMT was used as each person's index date. One-year outcomes included HBCs and absenteeism (lost time, comprising sick leave [SL], short- and long-term disability [STD/LTD], and workers' compensation). Demographics were compared using t-tests for continuous variables and chi-square tests for discrete variables. Two-part multivariate regression modeling (logistic regression combined with generalized linear regression) was used to determine annual HBCs and absenteeism for each cohort controlling for age, gender, job-related variables, and Charlson Comorbidity Score. All cost variables were inflated to US$2007. Annual ranges among the DMTs were: HBCs $17,953-26,970 and absenteeism 7.33-20.67 days. Compared with glatiramer acetate ('C'), IFN-beta1a IM ('A') users had lower SL ($445, p = 0.0469) and STD ($969, p = 0.0164) costs; and IFN-beta1b ('B') users had lower medical costs ($2143, p = 0.0091). In addition, those treated with 'A' had 4.2 fewer SL days (p = 0.0101) compared with those treated with 'C'. Patients treated with 'A' reported significantly lower SL costs, SL days, and STD costs than patients treated with 'C', suggestive of greater real world benefits with 'A'. Despite small sample sizes and the retrospective nature, the study provides interesting insights into the use of DMTs in MS. The study also revealed important areas of future research, specifically the need for development of methods to determine which MS patient groups respond best to which DMT treatments.

Within-Day Variability in the Quality of Classroom Interactions during Third and Fifth Grade: Implications for Children's Experiences and Conducting Classroom Observations

ERIC Educational Resources Information Center

Curby, Timothy W.; Stuhlman, Megan; Grimm, Kevin; Mashburn, Andrew; Chomat-Mooney, Lia; Downer, Jason; Hamre, Bridget; Pianta, Robert C.

2011-01-01

The quality of classroom interactions has typically been studied using aggregates of ratings over time. However, within-day ratings may contain important variability. This study investigated within-day variability using the NICHD Study of Early Childcare and Youth Development's observational data during grades 3 and 5. The first question examined…

The Optical Gravitational Lensing Experiment. Catalog of RRLyr Stars from the Small Magellanic Cloud

NASA Astrophysics Data System (ADS)

Soszynski, I.; Udalski, A.; Szymanski, M.; Kubiak, M.; Pietrzynski, G.; Wozniak, P.; Zebrun, K.; Szewczyk, O.; Wyrzykowski, L.

2002-12-01

We present the catalog of RRLyrae stars from 2.4 square degrees of central parts of the Small Magellanic Cloud (SMC). The photometric data were collected during four years of the OGLE-II microlensing survey. Photometry of each star was obtained using the Difference Image Analysis (DIA) method. The catalog contains 571 objects, including 458RRab, 56RRc variables, and 57 double mode RRLyr stars (RRd). Additionally we attach a list of variables with periods between 0.18-0.26 days, which are probably delta Sct stars. Period, BVI photometry, astrometry, amplitude, and parameters of the Fourier decomposition of the I-band light curve are provided for each object. We also present the Petersen diagram for double mode pulsators. We found that the SMC RRLyr stars are fairly uniformly distributed over the studied area, with no clear correlation to any location. The most preferred periods for RRab and RRc stars are 0.589 and 0.357 days, respectively. We noticed significant excess of stars with periods of about 0.29 days, which might be second-overtone RRLyr stars (RRe). The mean extinction free magnitudes derived for RRab stars are 18.97, 19.45 and 19.73 mag for the I, V and B-band, respectively. All presented data, including individual BVI observations, are available from the OGLE Internet archive.

VX Her: Eclipsing Binary System or Single Variable Star

NASA Astrophysics Data System (ADS)

Perry, Kathleen; Castelaz, Michael; Henson, Gary; Boghozian, Andrew

2015-01-01

VX Her is a pulsating variable star with a period of .4556504 days. It is believed to be part of an eclipsing binary system (Fitch et al. 1966). This hypothesis originated from Fitch seeing VX Her's minimum point on its light curve reaching a 0.7 magnitude fainter than normal and remaining that way for nearly two hours. If VX Her were indeed a binary system, I would expect to see similar results with a fainter minimum and a broader, more horizontal dip. Having reduced and analyzed images from the Southeastern Association for Research in Astronomy Observatory in Chile and Kitt Peak, as well as images from a 0.15m reflector at East Tennessee State University, I found that VX Her has the standard light curve of the prototype variable star, RR Lyrae. Using photometry, I found no differing features in its light curve to suggest that it is indeed a binary system. However, more observations are needed in case VX Her is a wide binary.

Diel Variability in Seawater pH Relates to Calcification and Benthic Community Structure on Coral Reefs

PubMed Central

Martz, Todd R.; Brainard, Russell E.

2012-01-01

Community structure and assembly are determined in part by environmental heterogeneity. While reef-building corals respond negatively to warming (i.e. bleaching events) and ocean acidification (OA), the extent of present-day natural variability in pH on shallow reefs and ecological consequences for benthic assemblages is unknown. We documented high resolution temporal patterns in temperature and pH from three reefs in the central Pacific and examined how these data relate to community development and net accretion rates of early successional benthic organisms. These reefs experienced substantial diel fluctuations in temperature (0.78°C) and pH (>0.2) similar to the magnitude of ‘warming’ and ‘acidification’ expected over the next century. Where daily pH within the benthic boundary layer failed to exceed pelagic climatological seasonal lows, net accretion was slower and fleshy, non-calcifying benthic organisms dominated space. Thus, key aspects of coral reef ecosystem structure and function are presently related to natural diurnal variability in pH. PMID:22952785

Spatial variability of hailfalls in France: an analysis of air mass retro-trajectories

NASA Astrophysics Data System (ADS)

Hermida, Lucía; Merino, Andrés; Sánchez, José Luis; Berthet, Claude; Dessens, Jean; López, Laura; Fernández-González, Sergio; Gascón, Estíbaliz; García-Ortega, Eduardo

2014-05-01

Hail is the main meteorological risk in south-west France, with the strongest hailfalls being concentrated in just a few days. Specifically, this phenomenon occurs most often and with the greatest severity in the Midi-Pyrénées area. Previous studies have revealed the high spatial variability of hailfall in this part of France, even leading to different characteristics being recorded on hailpads that were relatively close together. For this reason, an analysis of the air mass trajectories was carried out at ground level and at altitude, which subsequently led to the formation of the hail recorded by these hailpads. It is already known that in the study zone, the trajectories of the storms usually stretch for long distances and are oriented towards the east, leading to hailstones with diameters in excess of 3 cm, and without any change in direction above 3 km. We analysed different days with hail precipitation where there was at least one stone with a diameter of 3 cm or larger. Using the simulations from these days, an analysis of the backward trajectories of the air masses was carried out. We used the HYSPLIT (Hybrid Single Particle Lagrangian Integrated Trajectory Model) to determine the origin of the air masses, and tracked them toward each of the hailpads that were hit during the day studied. The height of the final points was the height of the impacted hailpads. Similarly, the backward trajectories for different heights were also established. Finally, the results show how storms that affect neighbouring hailpads come from very different air masses; and provide a deeper understanding of the high variability that affects the characteristics of hailfalls. Acknowledgements The authors would like to thank the Regional Government of Castile-León for its financial support through the project LE220A11-2. This study was supported by the following grants: GRANIMETRO (CGL2010-15930); MICROMETEO (IPT-310000-2010-22).

Review of Human Cognitive Performance in Spaceflight

NASA Technical Reports Server (NTRS)

Strangman, Gary; Bevan, Gary

2012-01-01

Human space exploration is inherently hazardous, particularly for lon g duration (LD) missions (22 days or longer). Maintenance of cognitive functioning is essential, but flight environments pose numerous pote ntial risks to the brain and cognitive performance (eg, radiation, to xins, chronic stress, sleep deprivation, hypercarbia, fluid shifts, h ormone imbalances, and injury). There have been persistent anecdotal reports of cognitive deficits during missions, but an up?-to-date rev iew of the evidence for such changes has remained unavailable. Method s: We identified and reviewed English language publications found via electronic searches in PubMed, PsycInfo, Inspec, the NASA Technical Report Server, and the Defense Technical Information Center, plus rec ursive searches of publication bibliographies. Search terms included the word cognition, cognitive, or performance along with spaceflight, flight, mission, or closely related terms. Results: Inter?-study variability precluded meta?-analysis. Some 32 published studies involving cognitive assessment during spaceflight were identified, involving a total of 110 participants (mean: 3.4 participants per study). The lo ngest?-duration study spanned 438 days, with six additional studies i nvolving flight durations of 90 days, and 11 more studies involved fl ight durations exceeding 21 days. The available evidence failed to st rongly support or refute the existence of cognitive deficits in LD sp aceflight, in part due to inadequate power or control conditions. Evi dence of increased variability in cognitive performance during spacef light, both within and between individuals, was common. Discussion: T hese results represent a negative finding based on small numbers of s ubjects for any given cognitive function. The increased variability within and (particularly) between individuals highlights the potential danger of generalizing from case studies. A mismatch therefore remain s between anecdotal reports describing generalized cognitive slowing, attention and memory problems during missions and the experimental e vidence supporting such deficits. Since a major justification for man ned spaceflight rests with the cognitive flexibility of humans, addit ional studies and further analysis of existing operational data appea rs warranted.

Assessing the ability of isotope-enabled General Circulation Models to simulate the variability of Iceland water vapor isotopic composition

NASA Astrophysics Data System (ADS)

Erla Sveinbjornsdottir, Arny; Steen-Larsen, Hans Christian; Jonsson, Thorsteinn; Ritter, Francois; Riser, Camilla; Messon-Delmotte, Valerie; Bonne, Jean Louis; Dahl-Jensen, Dorthe

2014-05-01

During the fall of 2010 we installed an autonomous water vapor spectroscopy laser (Los Gatos Research analyzer) in a lighthouse on the Southwest coast of Iceland (63.83°N, 21.47°W). Despite initial significant problems with volcanic ash, high wind, and attack of sea gulls, the system has been continuously operational since the end of 2011 with limited down time. The system automatically performs calibration every 2 hours, which results in high accuracy and precision allowing for analysis of the second order parameter, d-excess, in the water vapor. We find a strong linear relationship between d-excess and local relative humidity (RH) when normalized to SST. The observed slope of approximately -45 o/oo/% is similar to theoretical predictions by Merlivat and Jouzel [1979] for smooth surface, but the calculated intercept is significant lower than predicted. Despite this good linear agreement with theoretical calculations, mismatches arise between the simulated seasonal cycle of water vapour isotopic composition using LMDZiso GCM nudged to large-scale winds from atmospheric analyses, and our data. The GCM is not able to capture seasonal variations in local RH, nor seasonal variations in d-excess. Based on daily data, the performance of LMDZiso to resolve day-to-day variability is measured based on the strength of the correlation coefficient between observations and model outputs. This correlation coefficient reaches ~0.8 for surface absolute humidity, but decreases to ~0.6 for δD and ~0.45 d-excess. Moreover, the magnitude of day-to-day humidity variations is also underestimated by LMDZiso, which can explain the underestimated magnitude of isotopic depletion. Finally, the simulated and observed d-excess vs. RH has similar slopes. We conclude that the under-estimation of d-excess variability may partly arise from the poor performance of the humidity simulations.

Water Quality Conditions in Upper Klamath and Agency Lakes, Oregon, 2005

USGS Publications Warehouse

Hoilman, Gene R.; Lindenberg, Mary K.; Wood, Tamara M.

2008-01-01

During June-October 2005, water quality data were collected from Upper Klamath and Agency Lakes in Oregon, and meteorological data were collected around and within Upper Klamath Lake. Data recorded at two continuous water quality monitors in Agency Lake showed similar temperature patterns throughout the field season, but data recorded at the northern site showed more day-to-day variability for dissolved oxygen concentration and saturation after late June and more day-to-day variability for pH and specific conductance values after mid-July. Data recorded from the northern and southern parts of Agency Lake showed more comparable day-to-day variability in dissolved oxygen concentrations and pH from September through the end of the monitoring period. For Upper Klamath Lake, seasonal (late July through early August) lows of dissolved oxygen concentrations and saturation were coincident with a seasonal low of pH values and seasonal highs of ammonia and orthophosphate concentrations, specific conductance values, and water temperatures. Patterns in these parameters, excluding water temperature, were associated with bloom dynamics of the cyanobacterium (blue-green alga) Aphanizomenon flos-aquae in Upper Klamath Lake. In Upper Klamath Lake, water temperature in excess of 28 degrees Celsius (a high stress threshold for Upper Klamath Lake suckers) was recorded only once at one site during the field season. Large areas of Upper Klamath Lake had periods of dissolved oxygen concentration of less than 4 milligrams per liter and pH value greater than 9.7, but these conditions were not persistent throughout days at most sites. Dissolved oxygen concentrations in Upper Klamath Lake on time scales of days and months appeared to be influenced, in part, by bathymetry and prevailing current flow patterns. Diel patterns of water column stratification were evident, even at the deepest sites. This diel pattern of stratification was attributable to diel wind speed patterns and the shallow nature of most of Upper Klamath Lake. Timing of the daily extreme values of dissolved oxygen concentration, pH, and water temperature was less distinct with increased water column depth. Chlorophyll a concentrations varied spatially and temporally throughout Upper Klamath Lake. Location greatly affected algal concentrations, in turn affecting nutrient and dissolved oxygen concentrations - some of the highest chlorophyll a concentrations were associated with the lowest dissolved oxygen concentrations and the highest un-ionized ammonia concentrations. The occurrence of the low dissolved oxygen and high un-ionized ammonia concentrations coincided with a decline in algae resulting from cell death, as measured by concentrations of chlorophyll a. Dissolved oxygen production rates in experiments were as high as 1.47 milligrams of oxygen per liter per hour, and consumption rates were as much as -0.73 milligrams of oxygen per liter per hour. Dissolved oxygen consumption rates measured in this study were comparable to those measured in a 2002 Upper Klamath Lake study, and a higher rate of dissolved oxygen consumption was recorded in dark bottles positioned higher in the water column. Data, though inconclusive, indicated that a decreasing trend of dissolved oxygen productivity through July could have contributed to the decreasing dissolved oxygen concentrations and percent saturation recorded in Upper Klamath Lake during this time. Phytoplankton self-shading was evident from a general inverse relation between depth of photic zone and chlorophyll a concentrations. This shading caused net dissolved oxygen consumption during daylight hours in lower parts of the water column that would otherwise have been in the photic zone. Meteorological data collected in and around Upper Klamath Lake showed that winds were likely to come from a broad range of westerly directions in the northern one-third of the lake, but tended to come from a narrow range of northwesterly directions

Reliability and variability of day-to-day vault training measures in artistic gymnastics.

PubMed

Bradshaw, Elizabeth; Hume, Patria; Calton, Mark; Aisbett, Brad

2010-06-01

Inter-day training reliability and variability in artistic gymnastics vaulting was determined using a customised infra-red timing gate and contact mat timing system. Thirteen Australian high performance gymnasts (eight males and five females) aged 11-23 years were assessed during two consecutive days of normal training. Each gymnast completed a number of vault repetitions per daily session. Inter-day variability of vault run-up velocities (at -18 to -12 m, -12 to -6 m, -6 to -2 m, and -2 to 0 m from the nearest edge of the beat board), and board contact, pre-flight, and table contact times were determined using mixed modelling statistics to account for random (within-subject variability) and fixed effects (gender, number of subjects, number of trials). The difference in the mean (Mdiff) and Cohen's effect sizes for reliability assessment and intra-class correlation coefficients, and the coefficient of variation percentage (CV%) were calculated for variability assessment. Approach velocity (-18 to -2m, CV = 2.4-7.8%) and board contact time (CV = 3.5%) were less variable measures when accounting for day-to-day performance differences, than pre-flight time (CV = 17.7%) and table contact time (CV = 20.5%). While pre-flight and table contact times are relevant training measures, approach velocity and board contact time are more reliable when quantifying vaulting performance.

Inter- and intra-individual variation in urinary biomarker concentrations over a 6-day sampling period. Part 1: metals.

PubMed

Smolders, Roel; Koch, Holger M; Moos, Rebecca K; Cocker, John; Jones, Kate; Warren, Nick; Levy, Len; Bevan, Ruth; Hays, Sean M; Aylward, Lesa L

2014-12-01

The aim of the current HBM-study is to further the understanding of the impact of inter- and intra-individual variability in HBM surveys as it may have implications for the design and interpretation of the study outcomes. As spot samples only provide a snapshot in time of the concentrations of chemicals in an individual, it remains unclear to what extent intra-individual variability plays a role in the overall variability of population-wide HBM surveys. The current paper describes the results of an intensive biomonitoring study, in which all individual urine samples of 8 individuals were collected over a 6-day sampling period (a total of 352 unique samples). By analyzing different metals (As, Cd, Mn, Ni) in each individual sample, inter- and intra-individual variability for these four metals could be determined, and the relationships between exposure, internal dose, and sampling protocol assessed. Although the range of biomarker values for different metals was well within the normal range reported in large-scale population surveys, large intra-individual differences over a 6-day period could also be observed. Typically, measured biomarker values span at least an order of magnitude within an individual, and more if specific exposure episodes could be identified. Fish consumption for example caused a twenty- to thirty-fold increase in urinary As-levels over a period of 2-6h. Intra-class correlation coefficients (ICC) were typically low for uncorrected biomarker values (between 0.104 and 0.460 for the 4 metals), but improved when corrected for creatinine or specific gravity (SG). The results show that even though urine is a preferred matrix for HBM studies, there are certain methodological issues that need to be taken into account in the interpretation of urinary biomarker data, related to the intrinsic variability of the urination process itself, the relationship between exposure events and biomarker quantification, and the timing of sampling. When setting up HBM-projects, this expected relationship between individual exposure episode and urinary biomarker concentration needs to be taken into account. Copyright © 2014. Published by Elsevier Ireland Ltd.

Transient climate simulation from the Maunder Minimum to present day using prescribed changes in GHG, total/spectral solar irradiance and ozone

NASA Astrophysics Data System (ADS)

Spangehl, Thomas; Cubasch, Ulrich; Schimanke, Semjon

A fully coupled AO-GCM including representation of the middle atmosphere is used for tran-sient simulation of climate from 1630 to 2000 AD. For better representation of changes in the UV/visible part of the solar spectrum an improved short-wave radiation scheme is implemented. The model is driven by changes in GHG concentrations, solar activity and volcanic eruptions. Solar variability is introduced via changes in total/spectral solar irradiance (TSI/SSI) and pre-scribed changes in stratospheric ozone. The secular trend in TSI is in the range of 0.1 percent increase from Maunder Minimum to present-day. Volcanic eruptions are represented via abrupt reduction in TSI. With the applied forcings the model does not simulate a clear reduction of the annual Northern Hemisphere (NH) mean near surface temperature during Maunder Minimum. By contrast the Dalton Minimum is characterized by distinct cooling and there is a significant raise of NH mean near surface temperature until the end of the 20th century. Focusing on the North Atlantic/European region the winter mean near surface temperature change pat-tern from Late Maunder Minimum (1675-1715) to present-day (1960-1990) reveals maximum warming over north-eastern Europe and cooling over the western North Atlantic with maxi-mum cooling west of Greenland. These changes can partly be explained by a shift of the NAO towards a more positive phase. The simulated changes in tropospheric circulation are discussed with special emphasize on the role of the solar forcing. Besides the stratospheric solar forcing which may affect NAO variability via downward propagation of the solar signal from the strato-sphere to the troposphere the magnitude of the secular trend in TSI might play a role. For the period from Maunder Minimum to present-day the simulation shows less near surface temper-ature increase especially over arctic regions when compared to simulations performed with the same model including the standard radiation scheme but applying larger TSI variations. The associated changes in lower tropospheric baroclinicity are more favourable for synoptic scale wave activity over the North Atlantic and might thereby contribute to strengthening of the NAO.

Exceptional sequence of severe thunderstorms and related flash floods in May and June 2016 in Germany - Part 1: Meteorological background

NASA Astrophysics Data System (ADS)

Piper, David; Kunz, Michael; Ehmele, Florian; Mohr, Susanna; Mühr, Bernhard; Kron, Andreas; Daniell, James

2016-12-01

During a 15-day episode from 26 May to 9 June 2016, Germany was affected by an exceptionally large number of severe thunderstorms. Heavy rainfall, related flash floods and creek flooding, hail, and tornadoes caused substantial losses running into billions of euros (EUR). This paper analyzes the key features of the severe thunderstorm episode using extreme value statistics, an aggregated precipitation severity index, and two different objective weather-type classification schemes. It is shown that the thunderstorm episode was caused by the interaction of high moisture content, low thermal stability, weak wind speed, and large-scale lifting by surface lows, persisting over almost 2 weeks due to atmospheric blocking.For the long-term assessment of the recent thunderstorm episode, we draw comparisons to a 55-year period (1960-2014) regarding clusters of convective days with variable length (2-15 days) based on precipitation severity, convection-favoring weather patterns, and compound events with low stability and weak flow. It is found that clusters with more than 8 consecutive convective days are very rare. For example, a 10-day cluster with convective weather patterns prevailing during the recent thunderstorm episode has a probability of less than 1 %.

A decade of infrared versus visible AOD analysis within the dust belt

NASA Astrophysics Data System (ADS)

Capelle, Virginie; Chédin, Alain; Pondrom, Marc; Crevoisier, Cyril; Armante, Raymond; Crépeau, Laurent; Scott, Noëlle

2017-04-01

Aerosols represent one of the dominant uncertainties in radiative forcing, partly because of their very high spatiotemporal variability, a still insufficient knowledge of their microphysical and optical properties, or of their vertical distribution. A better understanding and forecasting of their impact on climate therefore requires precise observations of dust emission and transport. Observations from space offer a good opportunity to follow, day by day and at high spatial resolution, dust evolution at global scale and over long time series. In this context, infrared observations, by allowing retrieving simultaneously dust optical depth (AOD) as well as the mean dust layer altitude, daytime and nighttime, over oceans and over continents, in particular over desert, appears highly complementary to observations in the visible. In this study, a decade of infrared observations (Metop-A/IASI and AIRS/AQUA) has been processed pixel by pixel, using a "Look-Up-Table" (LUT) physical approach. The retrieved infrared 10µm coarse-mode AOD is compared with the Spectral Deconvolution Algorithm (SDA) 500nm coarse mode AOD observed at 50 ground-based Aerosol RObotic NETwork (AERONET) sites located within the dust belt. Analyzing their brings into evidence an important geographical variability. Lowest values are found close to dust sources ( 0.45 for the Sahel or Arabian Peninsula, 0.6-0.7 for the Northern part of Africa or India), whereas the ratio increases for transported dust with values of 0.9-1 for the Caribbean and for the Mediterranean basin. This variability is interpreted as a marker of clays abundance, and might be linked to the dust particle illite to kaolinite ratio, a recognized tracer of dust sources and transport. More generally, it suggests that the difference between the radiative impact of dust aerosols in the visible and in the infrared depends on the type of particles observed. This highlights the importance of taking into account the specificity of the infrared when considering the role of mineral dust on the Earth's energy budget.

Intraseasonal-to-semiannual variability of sea-surface height in the astern, equatorial Indian Ocean and southern Bay of Bengal

NASA Astrophysics Data System (ADS)

Cheng, Xuhua; McCreary, Julian P.; Qiu, Bo; Qi, Yiquan; Du, Yan

2017-05-01

Intraseasonal-to-semiannual variability of sea-surface height (SSH) in the eastern, equatorial Indian Ocean (EEIO) and southern Bay of Bengal (BoB) is investigated using altimetric data, and solutions to 1½ layer (first baroclinic mode) and linear, continuously stratified (LCS; multibaroclinic-mode) models. The amplitude and dominant periods of SSH variability differ regionally. Large-amplitude variability is found along the west coast of Sumatra, in a zonal band across the BoB centered along 5°N, east of Sri Lanka, and in the northwestern BoB, respectively. Along the Sumatran west coast, SSH variability peaks at 30-60, 90, and 180 days. Along 5°N and east of Sri Lanka, the 30-60 day variability is dominant. Sensitivity experiments using a nonlinear version of the 1½ layer model forced by realistic winds reproduce the observed patterns of intraseasonal variability in the southern BoB. At 30-60 days, the solutions show that eddies (nonlinear Rossby waves) propagating from the east, rather than local wind forcing, account for most of the variance east of Sri Lanka; furthermore, they demonstrate that the variance is significantly enhanced by the nonlinear transfer of 90-120 day energy into the intraseasonal band of 30-60 days. The LCS solutions show that the first two baroclinic modes explain most of the SSH variance at 90-180 days. The second baroclinic mode dominates the SSH variance at 180 days, a consequence of basin resonance and strong wind forcing.

Detection of major climatic and environmental predictors of liver fluke exposure risk in Ireland using spatial cluster analysis.

PubMed

Selemetas, Nikolaos; de Waal, Theo

2015-04-30

Fasciolosis caused by Fasciola hepatica (liver fluke) can cause significant economic and production losses in dairy cow farms. The aim of the current study was to identify important weather and environmental predictors of the exposure risk to liver fluke by detecting clusters of fasciolosis in Ireland. During autumn 2012, bulk-tank milk samples from 4365 dairy farms were collected throughout Ireland. Using an in-house antibody-detection ELISA, the analysis of BTM samples showed that 83% (n=3602) of dairy farms had been exposed to liver fluke. The Getis-Ord Gi* statistic identified 74 high-risk and 130 low-risk significant (P<0.01) clusters of fasciolosis. The low-risk clusters were mostly located in the southern regions of Ireland, whereas the high-risk clusters were mainly situated in the western part. Several climatic variables (monthly and seasonal mean rainfall and temperatures, total wet days and rain days) and environmental datasets (soil types, enhanced vegetation index and normalised difference vegetation index) were used to investigate dissimilarities in the exposure to liver fluke between clusters. Rainfall, total wet days and rain days, and soil type were the significant classes of climatic and environmental variables explaining the differences between significant clusters. A discriminant function analysis was used to predict the exposure risk to liver fluke using 80% of data for modelling and the remaining subset of 20% for post hoc model validation. The most significant predictors of the model risk function were total rainfall in August and September and total wet days. The risk model presented 100% sensitivity and 91% specificity and an accuracy of 95% correctly classified cases. A risk map of exposure to liver fluke was constructed with higher probability of exposure in western and north-western regions. The results of this study identified differences between clusters of fasciolosis in Ireland regarding climatic and environmental variables and detected significant predictors of the exposure risk to liver fluke. Copyright © 2015 Elsevier B.V. All rights reserved.

[Comparative study of two treatment methods for acute periodontal abscess].

PubMed

Jin, Dong-mei; Wang, Wei-qian

2012-10-01

The aim of this short-term study was to compare the clinical efficacy of 2 different methods to treat acute periodontal abscesses. After patient selection, 100 cases of acute periodontal abscess were randomly divided into two groups. The experimental group was treated by supra- and subgingival scaling, while the control group was treated by incision and drainage. A clinical examination was carried out to record the following variables: subjective clinical variables including pain, edema, redness and swelling; objective clinical variables including gingival index(GI), bleeding index(BI), probing depth(PD),suppuration, lymphadenopathy and tooth mobility. The data was analyzed with SPSS 19.0 software package. RESULES: Subjective clinical variables demonstrated statistically significant improvements with both methods from the first day after treatment and lasted for at least 30 days(P<0.05), but the results of experimental group showed much better than the control group 1 day and 7 days after treatment. 30 days after treatment, there was no significant difference between the two groups in pain and swelling improvement(P>0.05), but the experimental group showed more improvement in edema and redness than the control group(P<0.05).On improving objective variables, the experimental group showed significant improvement in GI,BI,PD and suppuration 1 day after treatment(P<0.05).After 7 days, all objective clinical variables in the experimental group improved significantly(P<0.05) in the control group, there were significant improvements in GI,suppuration,lymphadenopathy and tooth mobility(P<0.05) but the four variables of the experimental group showed more improvement than the control group(P<0.05).After 30 days, all objective clinical variables improved significantly in both groups as compared to baseline, but in the experimental group, improvements were more significant regarding to GI,BI,PD,suppuration and tooth mobility(P<0.05). The method of supra- and subgingival scaling was rapid and effective in treatment of acute periodontal abscesses.

The significant reduction of precipitation in Southern China during the Chinese Spring Festival

NASA Astrophysics Data System (ADS)

Zhang, J.; Gong, D.

2016-12-01

Long-term observational data from 2001 to 2012 over 339 stations were used to analyze the precipitation in southern China during the Chinese Spring Festival (CSF). It reveals both the precipitation frequency and precipitation intensity have a significant reduction around CSF holiday. From the second day to the sixth day after the Lunar New Year's Day, the daily mean precipitation frequency anomaly is -9%. At the same time, more than 90% stations in the study area have negative anomalies. The precipitation intensity has a continuous reduction from day 2 to day 4, which is up to 2mm in day 3. Other relevant variables, such as relative humidity and sunshine duration, have corresponding results to the precipitation's reduction during CSF. Atmospheric water vapor field's change leads to the reduction phenomenon. We analyzed the circulation configuration using the ERA-interim reanalysis data. It shows the anomalous north wind decrease the vapor and further affects the precipitation during the CSF period. The pollutants' concentration decreased around CSF, which may influence the meteorological field and lead to the anomalous north wind. Based on the S2S (sub-seasonal to seasonal prediction project) data, we calculated the circulation forecast difference to CSF period between clean days and polluted days. The result proves the north wind's existence and suggests that the aerosol decrease because of human activity may be partly responsible for the precipitation reduction during CSF.

Salivary cortisol values in HIV-positive people.

PubMed

Barroso, Julie; Burrage, Joe; Carlson, John; Carlson, Barbara Waag

2006-01-01

Fatigue is one of the most prevalent and troubling symptoms suffered by people with HIV infection. As part of a pilot study to examine physiological and psychosocial correlates of fatigue, the authors report results from a sample of 40 HIV-positive men and women who collected three saliva samples each over the course of a day. Few in the sample exhibited the normal salivary cortisol slope (a peak in the morning and falling throughout the day). There were four groups (N = 36) based on salivary cortisol plots: a normal downward trend (n = 7), an afternoon peak (n = 15), an afternoon drop (n = 9), and an upward trend (n = 5). The data in each of these groups were then analyzed on the key variables of sex, age, depression, state/trait anxiety, fatigue severity, CD4 count, and HIV viral load; the group that had an upward trend in cortisol values had a tendency toward more depression, more state and trait anxiety, higher fatigue severity, and higher HIV viral load. However, they also trended toward higher CD4 counts than the other three groups. The need to compare additional variables over a period of time is discussed.

Feeling old today? Daily health, stressors, and affect explain day-to-day variability in subjective age.

PubMed

Kotter-Grühn, Dana; Neupert, Shevaun D; Stephan, Yannick

2015-01-01

Subjective age is an important correlate of health, well-being, and longevity. So far, little is known about short-term variability in subjective age and the circumstances under which individuals feel younger/older in daily life. This study examined whether (a) older adults' felt age fluctuates on a day-to-day basis, (b) daily changes in health, stressors, and affect explain fluctuations in felt age, and (c) the daily associations between felt age and health, stressors, or affect are time-ordered. Using an eight-day daily diary approach, N = 43 adults (60-96 years, M = 74.65, SD = 8.19) filled out daily questionnaires assessing subjective age, health, daily stressors, and affect. Data were analysed using multilevel modelling. Subjective age, health, daily stressors, affect. Intra-individual variability in felt age was not explained by time but by short-term variability in other variables. Specifically, on days when participants experienced more than average health problems, stress, or negative affect they felt older than on days with average health, stress, or negative affect. No time-ordered effects were found. Bad health, many stressors, and negative affective experiences constitute circumstances under which older adults feel older than they typically do. Thus, daily measures of subjective age could be markers of health and well-being.

Effects of head-down bed rest on complex heart rate variability: Response to LBNP testing

NASA Technical Reports Server (NTRS)

Goldberger, Ary L.; Mietus, Joseph E.; Rigney, David R.; Wood, Margie L.; Fortney, Suzanne M.

1994-01-01

Head-down bed rest is used to model physiological changes during spaceflight. We postulated that bed rest would decrease the degree of complex physiological heart rate variability. We analyzed continuous heart rate data from digitized Holter recordings in eight healthy female volunteers (age 28-34 yr) who underwent a 13-day 6 deg head-down bed rest study with serial lower body negative pressure (LBNP) trials. Heart rate variability was measured on a 4-min data sets using conventional time and frequency domain measures as well as with a new measure of signal 'complexity' (approximate entropy). Data were obtained pre-bed rest (control), during bed rest (day 4 and day 9 or 11), and 2 days post-bed rest (recovery). Tolerance to LBNP was significantly reduced on both bed rest days vs. pre-bed rest. Heart rate variability was assessed at peak LBNP. Heart rate approximate entropy was significantly decreased at day 4 and day 9 or 11, returning toward normal during recovery. Heart rate standard deviation and the ratio of high- to low-power frequency did not change significantly. We conclude that short-term bed rest is associated with a decrease in the complex variability of heart rate during LBNP testing in healthy young adult women. Measurement of heart rate complexity, using a method derived from nonlinear dynamics ('chaos theory'), may provide a sensitive marker of this loss of physiological variability, complementing conventional time and frequency domain statistical measures.

The 30-60-day Intraseasonal Variability of Sea Surface Temperature in the South China Sea dur1ing May-September

NASA Astrophysics Data System (ADS)

Mao, Jiangyu; Wang, Ming

2018-05-01

This study investigates the structure and propagation of intraseasonal sea surface temperature (SST) variability in the South China Sea (SCS) on the 30-60-day timescale during boreal summer (May-September). TRMM-based SST, GODAS oceanic reanalysis and ERA-Interim atmospheric reanalysis datasets from 1998 to 2013 are used to examine quantitatively the atmospheric thermodynamic and oceanic dynamic mechanisms responsible for its formation. Power spectra show that the 30-60-day SST variability is predominant, accounting for 60% of the variance of the 10-90-day variability over most of the SCS. Composite analyses demonstrate that the 30-60-day SST variability is characterized by the alternate occurrence of basin-wide positive and negative SST anomalies in the SCS, with positive (negative) SST anomalies accompanied by anomalous northeasterlies (southwesterlies). The transition and expansion of SST anomalies are driven by the monsoonal trough-ridge seesaw pattern that migrates northward from the equator to the northern SCS. Quantitative diagnosis of the composite mixed-layer heat budgets shows that, within a strong 30-60-day cycle, the atmospheric thermal forcing is indeed a dominant factor, with the mixed-layer net heat flux (MNHF) contributing around 60% of the total SST tendency, while vertical entrainment contributes more than 30%. However, the entrainment-induced SST tendency is sometimes as large as the MNHF-induced component, implying that ocean processes are sometimes as important as surface fluxes in generating the 30-60-day SST variability in the SCS.

Variable cost of ICU care, a micro-costing analysis.

PubMed

Karabatsou, Dimitra; Tsironi, Maria; Tsigou, Evdoxia; Boutzouka, Eleni; Katsoulas, Theodoros; Baltopoulos, George

2016-08-01

Intensive care unit (ICU) costs account for a great part of a hospital's expenses. The objective of the present study was to measure the patient-specific cost of ICU treatment, to identify the most important cost drivers in ICU and to examine the role of various contributing factors in cost configuration. A retrospective cost analysis of all ICU patients who were admitted during 2011 in a Greek General, seven-bed ICU and stayed for at least 24hours was performed, by applying bottom-up analysis. Data collected included demographics and the exact cost of every single material used for patients' care. Prices were yielded from the hospital's purchasing costs and from the national price list of the imaging and laboratory tests, which was provided by the Ministry of Health. A total of 138 patients were included. Variable cost per ICU day was €573.18. A substantial cost variation was found in the total costs obtained for individual patients (median: €3443, range: €243.70-€116,355). Medicines were responsible for more than half of the cost and antibiotics accounted for the largest part of it, followed by blood products and cardiovascular drugs. Medical cause of admission, severe illness and increased length of stay, mechanical ventilation and dialysis were the factors associated with cost escalation. ICU variable cost is patient-specific, varies according to each patient's needs and is influenced by several factors. The exact estimation of variable cost is a pre-requisite in order to control ICU expenses. Copyright © 2016 Elsevier Ltd. All rights reserved.

John Goodricke, Edward Pigott, and Their Study of Variable Stars

NASA Astrophysics Data System (ADS)

French, Linda M.

2011-05-01

John Goodricke (1764-1786) and Edward Pigott (1753-1825) are credited with determining the first accurate periods for several important variable stars. Goodricke's name is associated with the determination of the period of the eclipsing binary Algol (Beta Persei); for this he was awarded the Copley Prize of the Royal Society of London. He also determined the periods of the contact binary Beta Lyrae and of Delta Cephei, the prototype Cepheid variable. Around the same time, Edward Pigott obtained the period of Eta Aquilae, another Cepheid. In actuality, the two collaborated on all these observations; today we would call them co-discoverers. Goodricke is the better known of the two, in part because he won the Copley Medal, in part because of his tragically short life, and in part because he was deaf. Edward Pigott was the more experienced observer, having worked with his father Nathaniel on determining the longitudes of several cities on the Continent. Evidence shows, however, that Goodricke had some astronomical experience while a student at the Warrington Academy. The journals of the two show that they developed a partnership that made the most of both their talents over the brief time (less than five years) they worked together before Goodricke's death. Today, the two are remembered as having suggested eclipses as the cause for the periodic dimming of Algol. This explanation is accepted today as the correct one. In their day, however, most eminent astronomers believed that starspots were a more likely cause for the dimming. By the time of John Goodricke's death, he seems to have accepted that explanation as well. A study of the work of Goodricke and Pigott contains many lessons for today's observers of variable stars. This work was supported by an AAS Small Research Grant and by the Pollack Award of the Dudley Observatory.

Is Low Health Literacy Associated with Increased Emergency Department Utilization and Recidivism?

PubMed Central

Griffey, Richard T.; Kennedy, Sarah K.; McGownan, Lucy; Goodman, Melody; Kaphingst, Kimberly A.

2015-01-01

Objectives To determine whether patients with low health literacy have higher ED utilization and higher ED recidivism than patients with adequate health literacy. Methods The study was conducted at an urban academic ED with over 95,000 annual visits that is part of a 13-hospital health system, using electronic records that are captured in a central data repository. As part of a larger, cross sectional, convenience sample study, health literacy testing was performed using the short test of functional health literacy in adults (STOFHLA), and standard test thresholds identifying those with inadequate, marginal, and adequate health literacy. The authors collected patients' demographic and clinical data, including items known to affect recidivism. This was a structured electronic record review directed at determining 1) the median number of total ED visits in this health system within a 2-year period, and 2) the proportion of patients with each level of health literacy who had return visits within 3, 7, and 14 days of index visits. Descriptive data for demographics and ED returns are reported, stratified by health literacy level. The Mantel-Haenszel chi-square was used to test whether there is an association between health literacy and ED recidivism. A negative binomial multivariable model was performed to examine whether health literacy affects ED use, including variables significant at the 0.1 alpha level on bivariate analysis, and retaining those significant at an alpha of 0.05 in the final model. Results Among 431 patients evaluated, 13.2% had inadequate, 10% had marginal, and 76.3% had adequate health literacy as identified by S-TOFHLA. Patients with inadequate health literacy had higher ED utilization compared to those with adequate health literacy (p = 0.03). Variables retained in the final model included S-TOFHLA score, number of medications, having a personal doctor, being a property owner, race, insurance, age, and simple comorbidity score. During the study period, 118 unique patients each made at least one return ED visit within a 14-day period. The proportion of patients with inadequate health literacy making at least one return visit was higher than that of patients with adequate health literacy at 14 days, but was not significantly higher within 3 or 7 days. Conclusions In this single-center study, higher utilization of the ED by patients with inadequate health literacy when compared to those with adequate health literacy was observed. Patients with inadequate health literacy made a higher number of return visits at 14 days but not at 3 or 7 days. PMID:25308133

Within-day variability on short and long walking tests in persons with multiple sclerosis.

PubMed

Feys, Peter; Bibby, Bo; Romberg, Anders; Santoyo, Carme; Gebara, Benoit; de Noordhout, Benoit Maertens; Knuts, Kathy; Bethoux, Francois; Skjerbæk, Anders; Jensen, Ellen; Baert, Ilse; Vaney, Claude; de Groot, Vincent; Dalgas, Ulrik

2014-03-15

To compare within-day variability of short (10 m walking test at usual and fastest speed; 10MWT) and long (2 and 6-minute walking test; 2MWT/6MWT) tests in persons with multiple sclerosis. Observational study. MS rehabilitation and research centers in Europe and US within RIMS (European network for best practice and research in MS rehabilitation). Ambulatory persons with MS (Expanded Disability Status Scale 0-6.5). Subjects of different centers performed walking tests at 3 time points during a single day. 10MWT, 2MWT and 6MWT at fastest speed and 10MWT at usual speed. Ninety-five percent limits of agreement were computed using a random effects model with individual pwMS as random effect. Following this model, retest scores are with 95% certainty within these limits of baseline scores. In 102 subjects, within-day variability was constant in absolute units for the 10MWT, 2MWT and 6MWT at fastest speed (+/-0.26, 0.16 and 0.15m/s respectively, corresponding to +/-19.2m and +/-54 m for the 2MWT and 6MWT) independent on the severity of ambulatory dysfunction. This implies a greater relative variability with increasing disability level, often above 20% depending on the applied test. The relative within-day variability of the 10MWT at usual speed was +/-31% independent of ambulatory function. Absolute values of within-day variability on walking tests at fastest speed were independent of disability level and greater with short compared to long walking tests. Relative within-day variability remained overall constant when measured at usual speed. Crown Copyright © 2014. Published by Elsevier B.V. All rights reserved.

Long-term trends in a Dimictic Lake

USGS Publications Warehouse

Robertson, Dale M.; Hsieh, Yi-Fang; Lathrop, Richard C; Wu, Chin H; Magee, Madeline; Hamilton, David P.

2016-01-01

 The one-dimensional hydrodynamic ice model, DYRESM-WQ-I, was modified to simulate ice cover and thermal structure of dimictic Lake Mendota, Wisconsin, USA, over a continuous 104-year period (1911–2014). The model results were then used to examine the drivers of changes in ice cover and water temperature, focusing on the responses to shifts in air temperature, wind speed, and water clarity at multiyear timescales. Observations of the drivers include a change in the trend of warming air temperatures from 0.081 °C per decade before 1981 to 0.334 °C per decade thereafter, as well as a shift in mean wind speed from 4.44 m s−1 before 1994 to 3.74 m s−1 thereafter. Observations show that Lake Mendota has experienced significant changes in ice cover: later ice-on date(9.0 days later per century), earlier ice-off date (12.3 days per century), decreasing ice cover duration (21.3 days per century), while model simulations indicate a change in maximum ice thickness (12.7 cm decrease per century). Model simulations also show changes in the lake thermal regime of earlier stratification onset (12.3 days per century), later fall turnover (14.6 days per century), longer stratification duration (26.8 days per century), and decreasing summer hypolimnetic temperatures (−1.4 °C per century). Correlation analysis of lake variables and driving variables revealed ice cover variables, stratification onset, epilimnetic temperature, and hypolimnetic temperature were most closely correlated with air temperature, whereas freeze-over water temperature, hypolimnetic heating, and fall turnover date were more closely correlated with wind speed. Each lake variable (i.e., ice-on and ice-off dates, ice cover duration, maximum ice thickness, freeze-over water temperature, stratification onset, fall turnover date, stratification duration, epilimnion temperature, hypolimnion temperature, and hypolimnetic heating) was averaged for the three periods (1911–1980, 1981–1993, and 1994–2014) delineated by abrupt changes in air temperature and wind speed. Average summer hypolimnetic temperature and fall turnover date exhibit significant differences between the third period and the first two periods. Changes in ice cover (ice-on and ice-off dates, ice cover duration, and maximum ice thickness) exhibit an abrupt change after 1994, which was related in part to the warm El Niño winter of 1997–1998. Under-ice water temperature, freeze-over water temperature, hypolimnetic temperature, fall turnover date, and stratification duration demonstrate a significant difference in the third period (1994–2014), when air temperature was warmest and wind speeds decreased rather abruptly. The trends in ice cover and water temperature demonstrate responses to both long-term and abrupt changes in meteorological conditions that can be complemented with numerical modeling to better understand how these variables will respond in a future climate.

Stratospheric variability in summer

NASA Technical Reports Server (NTRS)

Rind, D.; Donn, W. L.; Robinson, W.

1981-01-01

Rocketsonde observations and infrasound results are used to investigate the variability of the summer stratopause region during one month in summer. Fluctuations of 2-3 days and about 16-day periods are evident, and they appear to be propagating vertically. In this month the 2-3 day oscillations have an amplitude envelope equal in period to the longer period oscillations, implying a connection between the two phenomena. Observations of the diurnal tide and shorter period variability during the month are also presented.

Seasonal Variability of the 40-50 Day Oscillation in Wind and Rainfall in the Tropics.

NASA Astrophysics Data System (ADS)

Hartmann, Dennis L.; Gross, Jack R.

1988-10-01

Time spectral analysis is performed on long records of wind and precipitation from stations in the tropical Indian Ocean-Pacific Ocean are. The spectra are done separately for winter and summer half-years. Statistically significant spectral peaks in the 40-50 day period range show strong seasonal variability. The 40-50 day peaks in the 200 mb zonal wind spectra are stronger and more prevalent during the Northern Hemisphere winter half-year. Spectral peaks in the 850 mb wind show a preference for summer in the Northern Hemisphere.Precipitation spectra show significant 40-50 day peaks at selected locations in the Indonesian region and along the South Pacific convergence zone in the central Pacific during Southern Hemisphere summer. These oscillations in precipitation are coherent with nearby zonal wind oscillations. No significant oscillations in precipitation were found for stations significantly north of the equator during either half-year. In particular, no significant peaks in precipitation spectra were found for composites of stations on the Indian Peninsula during summer, where it has been proposed that the 40-50 day oscillation modulates monsoon precipitation.It is concluded that the 40-50 day oscillation is sustained by interactions between the large-scale flow and convective-scale processes and that these interactions take place in areas where intensely convective regions aye near the equator. The wind oscillation occupies a larger area, particularly at upper tropospheric levels, principally by horizontal wave propagation away from the excitation regions. Since the oscillation does not appear to be forced over India, it is conjectured that the seasonal variation in the intensity of the oscillation is attributable, in part, to the fact that the tropical convection is drawn away from the equator by the Indian summer monsoon. When the convection is drawn off the equator, the efficiency of the interaction with equatorially trapped modes declines, and hence the amplitude of the oscillation is less during Northern Hemisphere summer.

An Unusual Massive Be Star HD 53367: Circumstellar Activity and Evidence for Binarity

NASA Astrophysics Data System (ADS)

Pogodin, M. A.; Malanushenko, V. P.; Kozlova, O. V.; Tarasova, T. N.; Franco, G. A. P.

2006-12-01

We present the results of high-resolution spectroscopy of the young B0e star HD 53367 obtained within the framework of a cooperative observing program in 1994--2005. We confirm that a long-term photometric variability of the object is indeed connected with the alternation of two states of the object when the gaseous circumstellar envelope disappears and arises again. Both these processes start near the star and then spread to remote parts of the envelope. We find that the radial velocities of He I and O II photospheric lines demonstrate a cyclic variability with the period P=183.7 days and the semi-amplitude K=19 km s-1. The radial velocity variation is interpreted in the framework of a model, in which the star is a companion of an eccentric binary system. An orbital solution is derived and the system's parameters are estimated. We find that the orbital eccentricity is e=0.28, the mean companion separation is 1.7 AU, and the secondary companion is most likely to be a 5 solar mass pre-main sequence object. The main part of circumstellar gas in the system is collected near the secondary companion.

On the relationship between tropospheric conditions and widespread hot days in Iran

NASA Astrophysics Data System (ADS)

Asakereh, Hossein; Shadman, Hassan

2018-01-01

The present study investigated how the tropospheric conditions relate to the occurrence of widespread hot days (WHD) in Iran using the data of maximum daily temperature and other tropospheric variables. To better understand the tropospheric conditions during WHD, different patterns of tropospheric circulation were examined systematically. Four tropospheric types were identified based on sea level pressure (SLP). SLP, 500 hPa height, anomaly patterns, and warm advection maps were constructed for typical days of each group. The tropospheric conditions associated with hot days occurred simultaneously with a low-pressure system at sea level, a ridge at middle troposphere over Iran, and a pronounced trough over the Mediterranean Sea at 500 hPa. These conditions caused air mass from subtropical regions toward Iran. That is, northward, northeastward, and even eastward winds injected heat with warm origins toward the country. Hot days compounded by drought conditions have affected many parts of the country in different ways such as decrease in the agricultural products in numerous areas and significant discharge reduction in many rivers. The society is also very likely to face considerable challenges to cope with hot days. The findings of the study can be utilized in climate modeling and climate prediction of hot days in the country. Accordingly, water and electricity consumption can be planned with further precision and water consumption can be managed in crises.

Spatial and temporal variation in daily temperature indices in summer and winter seasons over India (1969-2012)

NASA Astrophysics Data System (ADS)

Kumar, Naresh; Jaswal, A. K.; Mohapatra, M.; Kore, P. A.

2017-08-01

Spatial and temporal variations in summer and winter extreme temperature indices are studied by using daily maximum and minimum temperatures data from 227 surface meteorological stations well distributed over India for the period 1969-2012. For this purpose, time series for six extreme temperature indices namely, hot days (HD), very hot days (VHD), extremely hot days (EHD), cold nights (CN), very cold nights (VCN), and extremely cold nights (ECN) are calculated for all the stations. In addition, time series for mean extreme temperature indices of summer and winter seasons are also analyzed. Study reveals high variability in spatial distribution of threshold temperatures of extreme temperature indices over the country. In general, increasing trends are observed in summer hot days indices and decreasing trends in winter cold night indices over most parts of the country. The results obtained in this study indicate warming in summer maximum and winter minimum temperatures over India. Averaged over India, trends in summer hot days indices HD, VHD, and EHD are significantly increasing (+1.0, +0.64, and +0.32 days/decade, respectively) and winter cold night indices CN, VCN, and ECN are significantly decreasing (-0.93, -0.47, and -0.15 days/decade, respectively). Also, it is observed that the impact of extreme temperature is higher along the west coast for summer and east coast for winter.

Psychophysiological responses of junior orienteers under competitive pressure.

PubMed

Robazza, Claudio; Izzicupo, Pascal; D'Amico, Maria Angela; Ghinassi, Barbara; Crippa, Maria Chiara; Di Cecco, Vincenzo; Ruiz, Montse C; Bortoli, Laura; Di Baldassarre, Angela

2018-01-01

The purpose of the study was to examine psychobiosocial states, cognitive functions, endocrine responses (i.e., salivary cortisol and chromogranin A), and performance under competitive pressure in orienteering athletes. The study was grounded in the individual zones of optimal functioning (IZOF) and biopsychosocial models. Fourteen junior orienteering athletes (7 girls and 7 boys), ranging in age from 15 to 20 years (M = 16.93, SD = 1.77) took part in a two-day competitive event. To enhance competitive pressure, emphasis was placed on the importance of the competition and race outcome. Psychophysiological and performance data were collected at several points before, during, and after the races. Results showed that an increase in cortisol levels was associated with competitive pressure and reflected in higher perceived exertion (day 1, r = .32; day 2, r = .46), higher intensity of dysfunctional states (day 1, r = .59; day 2, r = .55), lower intensity of functional states (day 1, r = -.36; day 2, r = -.33), and decay in memory (day 1, r = -.27; day 2, r = -.35), visual attention (day 1, r = -.56; day 2, r = -.35), and attention/mental flexibility (day 1, r = .16; day 2, r = .26) tasks. The second day we observed better performance times, lower intensity of dysfunctional states, lower cortisol levels, improved visual attention and attention/mental flexibility (p < .050). Across the two competition days, chromogranin A levels were higher (p < .050) on the most difficult loops of the race in terms of both physical and psychological demands. Findings suggest emotional, cognitive, psychophysiological, and performance variables to be related and to jointly change across different levels of cognitive and physical load. Overall results are discussed in light of the IZOF and biopsychosocial models. The procedure adopted in the study also supports the feasibility of including additional cognitive load for possible practical applications.

Psychophysiological responses of junior orienteers under competitive pressure

PubMed Central

Izzicupo, Pascal; D’Amico, Maria Angela; Ghinassi, Barbara; Crippa, Maria Chiara; Di Cecco, Vincenzo; Ruiz, Montse C.; Bortoli, Laura; Di Baldassarre, Angela

2018-01-01

The purpose of the study was to examine psychobiosocial states, cognitive functions, endocrine responses (i.e., salivary cortisol and chromogranin A), and performance under competitive pressure in orienteering athletes. The study was grounded in the individual zones of optimal functioning (IZOF) and biopsychosocial models. Fourteen junior orienteering athletes (7 girls and 7 boys), ranging in age from 15 to 20 years (M = 16.93, SD = 1.77) took part in a two-day competitive event. To enhance competitive pressure, emphasis was placed on the importance of the competition and race outcome. Psychophysiological and performance data were collected at several points before, during, and after the races. Results showed that an increase in cortisol levels was associated with competitive pressure and reflected in higher perceived exertion (day 1, r = .32; day 2, r = .46), higher intensity of dysfunctional states (day 1, r = .59; day 2, r = .55), lower intensity of functional states (day 1, r = -.36; day 2, r = -.33), and decay in memory (day 1, r = -.27; day 2, r = -.35), visual attention (day 1, r = -.56; day 2, r = -.35), and attention/mental flexibility (day 1, r = .16; day 2, r = .26) tasks. The second day we observed better performance times, lower intensity of dysfunctional states, lower cortisol levels, improved visual attention and attention/mental flexibility (p < .050). Across the two competition days, chromogranin A levels were higher (p < .050) on the most difficult loops of the race in terms of both physical and psychological demands. Findings suggest emotional, cognitive, psychophysiological, and performance variables to be related and to jointly change across different levels of cognitive and physical load. Overall results are discussed in light of the IZOF and biopsychosocial models. The procedure adopted in the study also supports the feasibility of including additional cognitive load for possible practical applications. PMID:29698498

Within-Hospital Variation in 30-Day Adverse Events: Implications for Measuring Quality.

PubMed

Burke, Robert E; Glorioso, Thomas; Barón, Anna K; Kaboli, Peter J; Ho, P Michael

Novel measures of hospital quality are needed. Because quality improvement efforts seek to reduce variability in processes and outcomes, hospitals with higher variability in adverse events may be delivering poorer quality care. We sought to evaluate whether within-hospital variability in adverse events after a procedure might function as a quality metric that is correlated with facility-level mortality rates. We analyzed all percutaneous coronary interventions (PCIs) performed in the Veterans Health Administration (VHA) system from 2007 to 2013 to evaluate the correlation between within-hospital variability in 30-day postdischarge adverse events (readmission, emergency department visit, and repeat revascularization), and facility-level mortality rates, after adjustment for patient demographics, comorbidities, PCI indication, and PCI urgency. The study cohort included 47,567 patients at 48 VHA hospitals. The overall 30-day adverse event rate was 22.0% and 1-year mortality rate was 4.9%. The most variable sites had relative changes of 20% in 30-day rates of adverse events period-to-period. However, within-hospital variability in 30-day events was not correlated with 1-year mortality rates (correlation coefficient = .06; p = .66). Thus, measuring within-hospital variability in postdischarge adverse events may not improve identification of low-performing hospitals. Evaluation in other conditions, populations, and in relationship with other quality metrics may reveal stronger correlations with care quality.

What difference does a day make? Examining temporal variations in partner maltreatment.

PubMed

McCarthy, Randy J; Rabenhorst, Mandy M; Milner, Joel S; Travis, Wendy J; Collins, Pamela S

2014-06-01

Routine activities (RA) theory posits that changes in people's typical daily activities covary with increases or decreases in criminal behaviors, including, but not limited to, partner maltreatment. Using a large clinical database, we examined temporal variations among 24,460 incidents of confirmed partner maltreatment across an 11-year period within the U.S. Air Force (USAF). Specifically, we created regression models that predicted the number of partner maltreatment incidents per day. In addition to several control variables, we coded temporal variables for days of the week, month, year, and several significant days (e.g., holidays, Super Bowl Sunday), which allowed us to examine the independent influence of these variables on partner maltreatment prevalence. While accounting for the influence of all other study variables, we observed significant increases in partner maltreatment for weekend days, New Year's Day, Independence Day, and Super Bowl Sunday. Similar results were found for partner maltreatment incidents involving offender alcohol/drug use. Furthermore, the proportion of incidents involving offender alcohol/drug use increased on New Year's Day and Independence Day. Consistent with RA theory and data from civilian samples, the current results indicate that certain days are associated with increased incidents of partner maltreatment within the USAF. These findings should be used to inform future preventive efforts. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Intra-individual variability in day-to-day and month-to-month measurements of physical activity and sedentary behaviour at work and in leisure-time among Danish adults.

PubMed

Pedersen, E S L; Danquah, I H; Petersen, C B; Tolstrup, J S

2016-12-03

Accelerometers can obtain precise measurements of movements during the day. However, the individual activity pattern varies from day-to-day and there is limited evidence on measurement days needed to obtain sufficient reliability. The aim of this study was to examine variability in accelerometer derived data on sedentary behaviour and physical activity at work and in leisure-time during week days among Danish office employees. We included control participants (n = 135) from the Take a Stand! Intervention; a cluster randomized controlled trial conducted in 19 offices. Sitting time and physical activity were measured using an ActiGraph GT3X+ fixed on the thigh and data were processed using Acti4 software. Variability was examined for sitting time, standing time, steps and time spent in moderate-to-vigorous physical activity (MVPA) per day by multilevel mixed linear regression modelling. Results of this study showed that the number of days needed to obtain a reliability of 80% when measuring sitting time was 4.7 days for work and 5.5 days for leisure time. For physical activity at work, 4.0 days and 4.2 days were required to measure steps and MVPA, respectively. During leisure time, more monitoring time was needed to reliably estimate physical activity (6.8 days for steps and 5.8 days for MVPA). The number of measurement days needed to reliably estimate activity patterns was greater for leisure time than for work time. The domain specific variability is of great importance to researchers and health promotion workers planning to use objective measures of sedentary behaviour and physical activity. Clinical trials NCT01996176 .

Long-term variability and changes of the precipitation regime in Pakistan

NASA Astrophysics Data System (ADS)

Hussain, Mian Sabir; Lee, Seungho

2014-05-01

This paper presents an examination of precipitation amounts in Pakistan. For this purpose, the annual precipitation and the annual number of precipitation days have been calculated, and a study aimed at investigating precipitation intensity and decadal changes was conducted. Precipitation trends have been calculated using a simple linear regression method and Kendall's tau-based test. To assess stability and differences, a 10-year span was determined for each precipitation region for the period of 1951-2010. This study focused on the three CLINO (Climatological Normal) periods, namely 1961-1990, 1971-2000, and 1981-2010 (the latest global standard normal period). Results confirm the gradual increase of annual precipitation in southwestern coastal areas of Pakistan and Cholistan desert. With regard to annual number of precipitation days, in the central part of the country negative trends were evident for wet days (with precipitation ≧ 0.1 mm), while the number of rainy days (with precipitation ≧ 1 mm) displayed a prominent positive trend. The series of the precipitation intensity gives evidence of a minor decrease in the Baluchistan Plateau, sub-Himalayas, and Potwar Plateau during the study period. Examination of secular trends evidenced that the Murree hills, the upper Indus plain, and the northwestern Baluchistan plateau have had shifts in their precipitation regime towards drier conditions, while the central plain, the northwestern mountains, and the southern part of the country are shifting in their precipitation regime towards wetter conditions. Description among the means of precipitation amounts suggests that "normal" precipitation data for various national projects should be calculated for the last 30 years.

Test--retest variability of Randot stereoacuity measures gathered in an unselected sample of UK primary school children.

PubMed

Adler, Paul; Scally, Andrew J; Barrett, Brendan T

2012-05-01

To determine the test-retest reliability of the Randot stereoacuity test when used as part of vision screening in schools. Randot stereoacuity (graded-circles) and logMAR visual acuity measures were gathered in an unselected sample of 139 children (aged 4-12, mean 8.1±2.1 years) in two schools. Randot testing was repeated on two occasions (average interval between successive tests 8 days, range: 1-21 days). Three Randot scores were obtained in 97.8% of children. Randot stereoacuity improved by an average of one plate (ie, one test level) on repeat testing but was little changed when tested on the third occasion. Within-subject variability was up to three test levels on repeat testing. When stereoacuity was categorised as 'fine', 'intermediate' or 'coarse', the greatest variability was found among younger children who exhibited 'intermediate' or 'coarse'/nil stereopsis on initial testing. Whereas 90.8% of children with 'fine' stereopsis (≤50 arc-seconds) on the first test exhibited 'fine' stereopsis on both subsequent tests, only ∼16% of children with 'intermediate' (>50 but ≤140 arc-seconds) or 'coarse'/nil (≥200 arc-seconds) stereoacuity on initial testing exhibited stable test results on repeat testing. Children exhibiting abnormal stereoacuity on initial testing are very likely to exhibit a normal result when retested. The value of a single, abnormal Randot graded-circles stereoacuity measure from school screening is therefore questionable.

Age differences in workplace intervention effects on employees’ nighttime and daytime sleep

PubMed Central

Lee, Soomi; Almeida, David M.; Berkman, Lisa; Olson, Ryan; Moen, Phyllis; Buxton, Orfeu M.

2017-01-01

Objectives To examine the effects of a workplace flexibility/support intervention on employees’ sleep quantity and quality during nights and days and whether the effects differ by employee age. Design Cluster-randomized controlled trial. Setting Information technology industry workplaces. Participants US employees (Mage = 46.9 years) at an information technology firm who provided actigraphy at baseline and a 12-month follow-up (N = 396; n = 195 intervention, n = 201 control). Intervention The Work, Family, and Health Study intervention aimed to increase workplace flexibility and support. The intervention consisted of facilitated discussions to help employees increase control over when and where they work as well as manager-specific training sessions to increase manager support for employees’ work-family issues. Measurements Nighttime sleep duration, wake after sleep onset (WASO), and nap duration were measured with wrist actigraphy. Day-to-day variability in these variables (min2) was also estimated. Results Intervention employees increased nighttime sleep duration at 12 months, by 9 minutes per day, relative to control employees. There were interaction effects between the intervention and age on daytime nap duration and day-to-day variability in WASO. Older employees (56–70 years) in the intervention condition decreased nap duration at 12 months relative to older employees in the control condition. Older employees in the intervention condition also exhibited a greater decrease in day-to-day variability of WASO at 12 months compared with their baseline. Conclusions The workplace flexibility/support intervention was effective in enhancing employees’ sleep health by increasing nighttime sleep duration. Furthermore, the intervention was particularly effective for older employees in decreasing their daytime nap duration and day-to-day variability in WASO. PMID:28105463

Relationships between atmospheric circulation indices and rainfall in Northern Algeria and comparison of observed and RCM-generated rainfall

NASA Astrophysics Data System (ADS)

Taibi, S.; Meddi, M.; Mahé, G.; Assani, A.

2017-01-01

This work aims, as a first step, to analyze rainfall variability in Northern Algeria, in particular extreme events, during the period from 1940 to 2010. Analysis of annual rainfall shows that stations in the northwest record a significant decrease in rainfall since the 1970s. Frequencies of rainy days for each percentile (5th, 10th, 25th, 50th, 75th, 90th, 95th, and 99th) and each rainfall interval class (1-5, 5-10, 10-20, 20-50, and ≥50 mm) do not show a significant change in the evolution of daily rainfall. The Tenes station is the only one to show a significant decrease in the frequency of rainy days up to the 75th percentile and for the 10-20-mm interval class. There is no significant change in the temporal evolution of extreme events in the 90th, 95th, and 99th percentiles. The relationships between rainfall variability and general atmospheric circulation indices for interannual and extreme event variability are moderately influenced by the El Niño-Southern Oscillation and Mediterranean Oscillation. Significant correlations are observed between the Southern Oscillation Index and annual rainfall in the northwestern part of the study area, which is likely linked with the decrease in rainfall in this region. Seasonal rainfall in Northern Algeria is affected by the Mediterranean Oscillation and North Atlantic Oscillation in the west. The ENSEMBLES regional climate models (RCMs) are assessed using the bias method to test their ability to reproduce rainfall variability at different time scales. The Centre National de Recherches Météorologiques (CNRM), Czech Hydrometeorological Institute (CHMI), Eidgenössische Technische Hochschule Zürich (ETHZ), and Forschungszentrum Geesthacht (GKSS) models yield the least biased results.

Clay mineralogy of surface sediments as a tool for deciphering river contributions to the Cariaco Basin (Venezuela)

NASA Astrophysics Data System (ADS)

Bout-Roumazeilles, V.; Riboulleau, A.; du Châtelet, E. Armynot; Lorenzoni, L.; Tribovillard, N.; Murray, R. W.; Müller-Karger, F.; Astor, Y. M.

2013-02-01

The mineralogical composition of 95 surface sediment samples from the Cariaco Basin continental shelf and Orinoco delta was investigated in order to constrain the clay-mineral main provenance and distribution within the Cariaco Basin. The spatial variability of the data set was studied using a geo-statistical approach that allows drawing representative clay-mineral distribution maps. These maps are used to identify present-day dominant sources for each clay-mineral species in agreement with the geological characteristics of the main river watersheds emptying into the basin. This approach allows (1) identifying the most distinctive clay-mineral species/ratios that determine particle provenance, (2) evaluating the respective contribution of local rivers, and (3) confirming the minimal present-day influence of the Orinoco plume on the Cariaco Basin sedimentation. The Tuy, Unare, and Neveri Rivers are the main sources of clay particles to the Cariaco Basin sedimentation. At present, the Tuy River is the main contributor of illite to the western part of the southern Cariaco Basin continental shelf. The Unare River plume, carrying smectite and kaolinite, has a wide westward propagation, whereas the Neveri River contribution is less extended, providing kaolinite and illite toward the eastern Cariaco Basin. The Manzanares, Araya, Tortuga, and Margarita areas are secondary sources of local influence. These insights shed light on the origin of present-day terrigenous sediments of the Cariaco Basin and help to propose alternative explanations for the temporal variability of clay mineralogy observed in previously published studies.

[Analysis of knowledge about healthy breakfast and its relation to life style habits and academic performance in compulsory secondary students].

PubMed

Córdoba Caro, Luis Gonzalo; Luengo Pérez, Luis Miguel; García Preciado, Ventura

2014-05-01

The main objective of the study is to analyze whether students of Compulsory Secondary Education (ESO) of Badajoz city known foods that are part of a healthy breakfast. It also intends to see the relationship of this knowledge with lifestyle habits and academic performance. A representative sample of 1197 secondary students in the city of Badajoz (Spain) (50.1% female) was calculated their Body Mass Index (BMI) and were asked to fill in a questionnaire, previously validated in a pilot study, which included sociodemographic items as well as others related with life style habits. They were also asked to choose among a series of food, which of them were a part of a healthy breakfast. 49.2% of adolescents know foods which are a part of a healthy breakfast. Very low correlations were obtained between all the variables analyzed and knowledge of foods that make up a healthy breakfast. However, within a few variables are significant differences (P<.05) between subgroups, such as families of students with low cultural level of aided schools, repeaters, without reading habit, passing lot of time with friends, who have been on a diet, make less than 3 meals a day and spend less than 10minutes for breakfast and know the amount of fruit that should be consumed daily. Life style habits of adolescents are not related to the knowledge about the foods that are part of a healthy breakfast. Copyright © 2013 SEEN. Published by Elsevier Espana. All rights reserved.

Photometric Periodicities of Be/X-Ray Pulsars in the Small Magellanic Cloud

NASA Astrophysics Data System (ADS)

Schmidtke, P. C.; Cowley, A. P.

2005-11-01

Analysis of the long-term photometric variability of seven Be/X-ray pulsar systems in the Small Magellanic Cloud has been carried out. We find that a variety of types of variability are present, including long-term irregular changes, periodic orbital outbursts due to interaction between the stars (weeks to months), low-amplitude quasi-periodic variations of the equatorial disk (days), and nonradial pulsations of the Be primary star (hours). This paper utilizes public domain data obtained by the MACHO Project, jointly funded by the US Department of Energy through the University of California, Lawrence Livermore National Laboratory, under contract W-7405-Eng-48, by the National Science Foundation through the Center for Particle Astrophysics of the University of California under cooperative agreement AST 88-09616, and by the Mount Stromlo and Siding Spring Observatory, part of the Australian National University.

Thermal maps of Jupiter - Spatial organization and time dependence of stratospheric temperatures, 1980 to 1990

NASA Technical Reports Server (NTRS)

Orton, Glenn S.; Friedson, A. James; Baines, Kevin H.; Martin, Terry Z.; West, Robert A.; Caldwell, John; Hammel, Heidi B.; Bergstralh, Jay T.; Malcolm, Michael E.

1991-01-01

The spatial organization and time dependence of Jupiter's stratospheric temperatures have been measured by observing thermal emission from the 7.8-micrometer CH4 band. These temperatures, observed through the greater part of a Jovian year, exhibit the influence of seasonal radiative forcing. Distinct bands of high temperature are located at the poles and midlatitudes, while the equator alternates between warm and cold with a period of approximately 4 years. Substantial longitudinal variability is often observed within the warm midlatitude bands, and occasionally elsewhere on the planet. This variability includes small, localized structures, as well as large-scale waves with wavelengths longer than about 30,000 kilometers. The amplitudes of the waves vary on a time scale of about 1 month; structures on a smaller scale may have lifetimes of only days. Waves observed in 1985, 1987, and 1988 propagated with group velocities less than + or - 30 meters/sec.

Impact of resolving the diurnal cycle in an ocean-atmosphere GCM. Part 2: A diurnally coupled CGCM

NASA Astrophysics Data System (ADS)

Bernie, D. J.; Guilyardi, E.; Madec, G.; Slingo, J. M.; Woolnough, S. J.; Cole, J.

2008-12-01

Coupled ocean atmosphere general circulation models (GCM) are typically coupled once every 24 h, excluding the diurnal cycle from the upper ocean. Previous studies attempting to examine the role of the diurnal cycle of the upper ocean and particularly of diurnal SST variability have used models unable to resolve the processes of interest. In part 1 of this study a high vertical resolution ocean GCM configuration with modified physics was developed that could resolve the diurnal cycle in the upper ocean. In this study it is coupled every 3 h to atmospheric GCM to examine the sensitivity of the mean climate simulation and aspects of its variability to the inclusion of diurnal ocean-atmosphere coupling. The inclusion of the diurnal cycle leads to a tropics wide increase in mean sea surface temperature (SST), with the strongest signal being across the equatorial Pacific where the warming increases from 0.2°C in the central and western Pacific to over 0.3°C in the eastern equatorial Pacific. Much of this warming is shown to be a direct consequence of the rectification of daily mean SST by the diurnal variability of SST. The warming of the equatorial Pacific leads to a redistribution of precipitation from the Inter tropical convergence zone (ITCZ) toward the equator. In the western Pacific there is an increase in precipitation between Papa new guinea and 170°E of up to 1.2 mm/day, improving the simulation compared to climatology. Pacific sub tropical cells are increased in strength by about 10%, in line with results of part 1 of this study, due to the modification of the exchange of momentum between the equatorially divergent Ekman currents and the geostropic convergence at depth, effectively increasing the dynamical response of the tropical Pacific to zonal wind stresses. During the spring relaxation of the Pacific trade winds, a large diurnal cycle of SST increases the seasonal warming of the equatorial Pacific. When the trade winds then re-intensify, the increase in the dynamical response of the ocean leads to a stronger equatorial upwelling. These two processes both lead to stronger seasonal basin scale feedbacks in the coupled system, increasing the strength of the seasonal cycle of the tropical Pacific sector by around 10%. This means that the diurnal cycle in the upper ocean plays a part in the coupled feedbacks between ocean and atmosphere that maintain the basic state and the timing of the seasonal cycle of SST and trade winds in the tropical Pacific. The Madden-Julian Oscillation (MJO) is examined by use of a large scale MJO index, lag correlations and composites of events. The inclusion of the diurnal cycle leads to a reduction in overall MJO activity. Precipitation composites show that the MJO is stronger and more coherent when the diurnal cycle of coupling is resolved, with the propagation and different phases being far more distinct both locally and to larger lead times across the tropical Indo-Pacific. Part one of this study showed that that diurnal variability of SST is modulated by the MJO and therefore increases the intraseasonal SST response to the different phases of the MJO. Precipitation-based composites of SST variability confirm this increase in the coupled simulations. It is argued that including this has increased the thermodynamical coupling of the ocean and atmosphere on the timescale of the MJO (20-100 days), accounting for the improvement in the MJO strength and coherency seen in composites of precipitation and SST. These results show that the diurnal cycle of ocean-atmosphere interaction has profound impact on a range of up-scale variability in the tropical climate and as such, it is an important feature of the modelled climate system which is currently either neglected or poorly resolved in state of the art coupled models.

Improving Autopsy Report Turnaround Times by Implementing Lean Management Principles.

PubMed

Cromwell, Susan; Chiasson, David A; Cassidy, Debra; Somers, Gino R

2018-01-01

The autopsy is an integral part of the service of a large academic pathology department. Timely reporting is central to providing good service and is beneficial for many stakeholders, including the families, the clinical team, the hospital, and the wider community. The current study aimed to improve hospital-consented autopsy reporting times (turnaround time, TAT) by using lean principles modified for a healthcare setting, with an aim of signing out 90% of autopsies in 90 days. An audit of current and historical TATs was performed, and a working group incorporating administrative, technical, and professional staff constructed a value stream map documenting the steps involved in constructing an autopsy report. Two areas of delay were noted: examination of the microscopy and time taken to sign-out the report after the weekly autopsy conference. Several measures were implemented to address these delays, including visual tracking using a whiteboard and individualized tracking sheets, weekly whiteboard huddles, and timelier scheduling of clinicopathologic conference rounds. All measures resulted in an improvement of TATs. In the 30 months prior to the institution of lean, 37% of autopsies (53/144) were signed out in 90 days, with a wide variation in reporting times. In the 30 months following the institution of lean, this improved to 74% (136/185) ( P < .0001, Fisher exact test), with a marked reduction in variability. Further, the time from autopsy to presentation at weekly clinicopathological rounds was also reduced (median: 73 days prior to lean; 63 days post-lean). The application of lean principles to autopsy sign-out workflow can significantly improve TATs and reduce variability, without changing staffing levels or significantly altering scheduling structure.

Connecting Variability and Metals in White Dwarfs

NASA Astrophysics Data System (ADS)

Kilic, Mukremin

2016-10-01

The Kepler and K2 missions have revealed that about half of the observed white dwarfs with sufficient signal-to-noise ratio light curves have low-level photometric variations at hour to day timescales. Potential explanations for the observed variability include the relativistic beaming effect, ellipsodial variations, eclipses, and reflection off of giant planets in close orbits. However, these are all rare events. Roughly 10% of white dwarfs are magnetic, and magnetic fields can explain part of this puzzle. However, the high incidence (50%) of variability is currently unexplained. HST COS spectroscopy of nearby white dwarfs show that about half of them have metals on their surface. Hence, we propose that the observed variability is due to the rotation of the star coupled with an inhomogeneous surface distribution of accreted metals. We have recently discovered an ideal system to test this hypothesis. J1529 is an apparently non-magnetic white dwarf that shows 5.9% photometric dips in the optical every 38 min. We propose to obtain COS TIME-TAG spectroscopy of J1529 over 4 orbits to search for surface abundance differences throughout the orbit and look for the flux redistribution effect in the optical. These observations will confirm or rule out the idea that inhomogeneous metal accretion on white dwarfs can explain the high incidence of variability. We predict that the LSST will identify 100,000 variable white dwarfs. Hence, understanding the source of variability in white dwarfs has implications for the current and future transient surveys.

Proglacial River Reveals Substantial Greenland Ice Sheet Climate Sensitivity and Meltwater Routing Delays

NASA Astrophysics Data System (ADS)

van As, D.; Mikkelsen, A. B.; Holtegaard Nielsen, M.; Claesson Liljedahl, L.; Lindback, K.; Pitcher, L. H.; Hasholt, B.

2016-12-01

A 12.000 km2 area of the Greenland ice sheet discharges meltwater via the proglacial Watson River in west Greenland. In a ten-year time span of continuous monitoring (2006-2015), the river discharged 3.8 km3 to 11.2 km3 yr-1. The large interannual variability is for an important part explained by hypsometric amplification: the flattening of the ice sheet with elevation adds 70% meltwater discharge sensitivity to atmospheric temperature. Comparing river discharge with ice sheet surface meltwater production from an observation-based surface mass balance model we quantify multiple-day routing delays for meltwater transit through the supra-, en-, sub- and proglacial system. This delay increases with ice sheet surface elevation: on average five days for surface water at the previous-known equilibrium line altitude (ELA) of ca. 1550 m, and seven days at the 2009-2015 ELA of ca. 1800 m above sea level. A flooding of the Kangerlussuaq bridge as in July 2012 thus requires a multi-day high-melt episode and can therefore be anticipated by in-situ monitoring of ice sheet melt. No evidence of significant en- or subglacial meltwater retention is found.

The effects of harvest regulations on behaviors of duck hunters

USGS Publications Warehouse

Haugen, Matthew T.; Powell, Larkin A.; Vrtiska, Mark P.; Pope, Kevin L.

2015-01-01

Uncertainty exists as to how duck harvest regulations influence waterfowl hunter behavior. We used the U.S. Fish and Wildlife Service’s Parts Collection Survey to examine how harvest regulations affected behaviors of Central Flyway duck hunters. We stratified hunters into ranked groups based on seasonal harvest and identified three periods (1975–1984, 1988–1993, 2002–2011) that represented different harvest regulations (moderate, restrictive, and liberal, respectively; season length and daily bag limits smallest in restrictive seasons and largest in liberal seasons). We examined variability of seven measures of duck hunter behaviors across the periods: days harvesting ducks, daily harvest, hunter mobility, mallard (Anas platyrhynchos) selectivity, gender selectivity, daily female mallard harvest, and timing of harvest. Hunters reported harvesting ducks on more days, at a higher efficiency, and in slightly more counties during liberal seasons relative to restrictive and moderate seasons. We provide evidence to suggest that future regulation change will affect hunter behaviors.

A QC approach to the determination of day-to-day reproducibility and robustness of LC-MS methods for global metabolite profiling in metabonomics/metabolomics.

PubMed

Gika, Helen G; Theodoridis, Georgios A; Earll, Mark; Wilson, Ian D

2012-09-01

An approach to the determination of day-to-day analytical robustness of LC-MS-based methods for global metabolic profiling using a pooled QC sample is presented for the evaluation of metabonomic/metabolomic data. A set of 60 urine samples were repeatedly analyzed on five different days and the day-to-day reproducibility of the data obtained was determined. Multivariate statistical analysis was performed with the aim of evaluating variability and selected peaks were assessed and validated in terms of retention time stability, mass accuracy and intensity. The methodology enables the repeatability/reproducibility of extended analytical runs in large-scale studies to be determined, allowing the elimination of analytical (as opposed to biological) variability, in order to discover true patterns and correlations within the data. The day-to-day variability of the data revealed by this process suggested that, for this particular system, 3 days continuous operation was possible without the need for maintenance and cleaning. Variation was generally based on signal intensity changes over the 7-day period of the study, and was mainly a result of source contamination.

Effects of an online alcohol education course among college freshmen: an investigation of potential mediators.

PubMed

Paschall, Mallie J; Ringwalt, Chris; Wyatt, Todd; Dejong, William

2014-04-01

The authors investigated possible mediating effects of psychosocial variables (perceived drinking norms, positive and negative alcohol expectancies, personal approval of alcohol use, protective behavioral strategies) targeted by an online alcohol education course (AlcoholEdu for College) as part of a 30-campus randomized trial with 2,400 first-year students. Previous multilevel analyses have found significant effects of the AlcoholEdu course on the frequency of past-30-day alcohol use and binge drinking during the fall semester, and the most common types of alcohol-related problems. Exposure to the online AlcoholEdu course was inversely related to perceived drinking norms but was not related to any of the other psychosocial variables. Multilevel analyses indicated at least partial mediating effects of perceived drinking norms on behavioral outcomes. Findings of this study suggest that AlcoholEdu for College affects alcohol use and related consequences indirectly through its effect on student perceptions of drinking norms. Further research is needed to better understand why this online course did not appear to affect other targeted psychosocial variables.

Empirical meaning of DTM multifractal parameters in the precipitation context

NASA Astrophysics Data System (ADS)

Portilla Farfan, Freddy; Valencia, Jose Luis; Villeta, Maria; Tarquis, Ana M.; Saa-Requejo, Antonio

2015-04-01

The main objective of this research is to interpret the multifractal parameters in the case of precipitation series from an empirical approach. In order to do so nineteen precipitation series were generated with a daily precipitation simulator derived from year and month estimations and considering the classical statistics, used commonly in hydrology studies, from actual data of four Spanish rain gauges located in a gradient from NW to SE. For all generated series the multifractal parameters were estimated following the technique DTM (Double Trace Moments) developed by Lavalle et al. (1993) and the variations produced considered. The results show the following conclusions: 1. The intermittency, C1, increases when precipitation is concentrating for fewer days, making it more variable, or when increasing its concentration on maximum monthly precipitation days, while it is not affected due to the modification in the variability in the number of days rained. 2. Multifractility, α, increases with the number of rainy days and the variability of the precipitation, yearly as well as monthly, as well as with the concentration of precipitation on the maximum monthly precipitation day. 3. The maximum probable singularity, γs, increases with the concentration of rain on the day of the maximum monthly precipitation and the variability in yearly and monthly level. 4. The non-conservative degree, H, depends on the number of rainy days that appear on the series and secondly on the general variability of the rain. References Lavallée D., S. Lovejoy, D. Schertzer and P. Ladoy, 1993. Nonlinear variability and landscape topography: analysis and simulation. In: Fractals in Geography (N. Lam and L. De Cola, Eds.) Prentice Hall, Englewood Cliffs, 158-192.

Meteorological variables to aid forecasting deep slab avalanches on persistent weak layers

USGS Publications Warehouse

Marienthal, Alex; Hendrikx, Jordy; Birkeland, Karl; Irvine, Kathryn M.

2015-01-01

Deep slab avalanches are particularly challenging to forecast. These avalanches are difficult to trigger, yet when they release they tend to propagate far and can result in large and destructive avalanches. We utilized a 44-year record of avalanche control and meteorological data from Bridger Bowl ski area in southwest Montana to test the usefulness of meteorological variables for predicting seasons and days with deep slab avalanches. We defined deep slab avalanches as those that failed on persistent weak layers deeper than 0.9 m, and that occurred after February 1st. Previous studies often used meteorological variables from days prior to avalanches, but we also considered meteorological variables over the early months of the season. We used classification trees and random forests for our analyses. Our results showed seasons with either dry or wet deep slabs on persistent weak layers typically had less precipitation from November through January than seasons without deep slabs on persistent weak layers. Days with deep slab avalanches on persistent weak layers often had warmer minimum 24-hour air temperatures, and more precipitation over the prior seven days, than days without deep slabs on persistent weak layers. Days with deep wet slab avalanches on persistent weak layers were typically preceded by three days of above freezing air temperatures. Seasonal and daily meteorological variables were found useful to aid forecasting dry and wet deep slab avalanches on persistent weak layers, and should be used in combination with continuous observation of the snowpack and avalanche activity.

Precision Photometry of Long Period Variable Stars: Flares and Bumps in the Night (Poster abstract)

NASA Astrophysics Data System (ADS)

Mais, D.

2015-06-01

(Abstract only) Mira variable stars are a broad class of stars, which encompass spectroscopic classes of type M, S, and C. These stars are closely related in terms of their long term variability, position on the Hertzsprung-Russell diagram their intermediate mass (from ~0.8 to ~8 solar mass) and the fact that class M evolves into the S and C type stars as certain stages of shell burning around the core proceeds. Recently, evidence has accumulated to suggest that Mira variables may go through flare up stages which result in brightening on the order of several tenths of a magnitude or more and may last hours to days in length. Very little is known about these events, indeed it is not clear that these events are real. In order to address the reality of these events, we established an automated acquisition/analysis of a group of 108 Mira variables in order to obtain the densest coverage of the periods to better constrain the potential flare-ups. Telescope control scripts were put in place along with real time analysis. This allowed for unattended acquisition of data on every clear night, all night long, in the V, R, and I photometric bands. In addition, during the course of the night multiple determinations are often obtained for a given star. The light curves of many of the program stars show a Cepheid-like bump phenomenon, however these appear on the ascending part of the light curve. In general, these bumps appear in longer period Mira's (>350 days). Bumps are not obvious or easily seen in VISUAL data records, although slope changes during rising phase are seen in some cases. So far, greater than 100,000 magnitude determinations have been obtained, many closely spaced in time. This should help to further constrain the potential occurrences of flare-up events.

Accounting for the impact of short-term variations in the levels of trihalomethane in drinking water on exposure assessment for epidemiological purposes. Part II: biological aspects.

PubMed

Catto, Cyril; Charest-Tardif, Ginette; Rodriguez, Manuel; Tardif, Robert

2013-01-01

The variability of trihalomethane (THM) levels in drinking water raises the question of whether or not short-term variations (within-day) should be accounted for when assessing exposure to contaminants suspected of being carcinogenic and reprotoxic agents. The purpose of this study was to determine the magnitude of the impact on predicted biological levels of THMs (internal doses) exerted by within-day variations of THMs in drinking water. A database extracted from a campaign in the Québec City distribution system served to produce 81, 79 and 64 concentration profiles for the three most abundant THMs, namely chloroform (TCM), dichlorobromomethane (DCBM) and chlorodibromomethane (CDBM), respectively. Using a physiologically based toxicokinetic modeling approach, we simulated exposures (1.5 l water per day and a 10-min shower) based on each of these profiles and predicted, for 2000 individuals (Monte-Carlo simulations), maximum blood concentrations (Cmax), areas under the time versus blood concentrations curve (24 h-AUCcv) and total absorbed doses (ADs). Three different hypotheses were tested: [A] assuming a constant THM concentration in water (e.g., mean value of a day); [B] accounting for within-day variations in THM levels; and [C] a worst-case scenario assuming within-day variations and showering while THM levels were maximal. For each exposure profile, exposure indicator and individual, we calculated the ratios of values obtained according to each hypothesis (e.g., CmaxB/CmaxA and CmaxC/CmaxA) and the values corresponding to the 5th and 95th percentiles of these ratios. The closer these percentiles are to the value of 1, the smaller the error associated with assuming constant THM concentrations rather than their actual variability. Results showed that the minimal gap between these percentiles was TCM-AD(B)/TCM-AD(A) (5th=0.91; 95th=1.09), whereas the maximal gap was CDBM-Cmax(C)/CDBM-Cmax(A) (5th=0.50; 95th=3.40). Overall, TCM and ADs were the less affected (TCM

Short-Term Variability on the Scotian Shelf

NASA Astrophysics Data System (ADS)

Greenan, B.; Petrie, B.; Harrison, G.; Oakey, N.; Strain, P.

2002-12-01

The traditional view of the production cycle on the continental shelf of Nova Scotia features a spring bloom followed by a period of low production and a less intense fall bloom. The annual cycle of primary productivity thus has a large, low frequency component. However, there is increasing evidence that the production cycle has significant variability on shorter time scales. Physical, chemical and biological variability on the Scotian Shelf is examined on a daily to weekly timescale. This is accomplished through the use of a newly developed mooring platform (SeaHorse) that uses surface wave energy to enable the instrument to climb down the mooring wire and then float upwards while sampling the water column. This provides bi-hourly profiles of temperature, salinity, pressure and chlorophyll at one location over month-long periods. Results from the three-week deployment in October 2000 indicate a subsurface chlorophyll maximum below the pycnocline during the first part of the time series. An event occurred in mid-October during which the temperature, salinity and density iso-surfaces rose approximately 25 m. During this event, a small bloom, with peak chlorophyll concentrations of about 2 mg m-3 and duration of several days, began as nutrients were brought into the upper part of the water column by upwelling-favorable winds. SeaWiFS ocean color satellite images were valuable in providing a spatial context for chlorophyll concentrations, however, the lack of temporal resolution due to poor quality images means that this data set provided limited information for short-term chlorophyll variability. Gradient Richardson Numbers were estimated for 2 m vertical bins using SeaHorse CTD data and nearby ADCP current measurements. A trend of decreasing Ri in the ocean mixed layer with increasing surface wind stress is suggested.

Factors associated with differences in quit rates between "specialist" and "community" stop-smoking practitioners in the english stop-smoking services.

PubMed

McDermott, Máirtín S; Beard, Emma; Brose, Leonie S; West, Robert; McEwen, Andy

2013-07-01

Behavioral support improves smokers' chances of quitting, but quit rates are typically lower for smokers supported by "community practitioners" for whom smoking cessation is a small part of their job than for those supported by "specialist practitioners" for whom it is the main role. This article examined the factors that might contribute to this. A total of 573 specialist practitioners and 466 community practitioners completed a 42-item online survey that covered demographic and employment information, current practices, levels of training, and 4-week CO-verified quit rates. Responses were compared for community and specialist practitioners. Mediation analysis was undertaken to assess how far "structural" and "modifiable" variables account for the difference in quit rates. Specialist practitioners reported higher 4-week CO-verified quit rates than community practitioners (63.6% versus 50.4%, p < .001). Practitioners also differed significantly in employment variables, evidence-based practices, and levels of training. Six "modifiable" variables (proportion of clients using an "abrupt" quit model, duration of first session, always advising on medications, number of days training received, number of sessions observed when starting work, and number of sessions having been observed in practice and received feedback) mediated the association between practitioners' role and quit rates over and above the "structural" variables, explaining 14.3%-35.7% of the variance in the total effect. "Specialist" practitioners in the English stop-smoking services report higher success rates than "community" practitioners and this is at least in part attributable to more extensive training and supervision and greater adherence to evidence-based practice including advising on medication usage and promoting abrupt rather than gradual quitting.

Exploring the use of mothers' own milk as oral care for mechanically ventilated very low-birth-weight preterm infants.

PubMed

Thibeau, Shelley; Boudreaux, Cynthia

2013-06-01

The purpose of this study was to explore the use of mothers' own milk (colostrums, transitional milk, and mature milk) as oral care in the ventilator-associated pneumonia (VAP)-prevention bundle of mechanically ventilated preterm infants weighing 1500 g or less. Mechanically ventilated preterm infants weighing 1500 g or less admitted to a regional level III NICU in the Gulf South between January 1, 2006, and December 31, 2009. Retrospective descriptive. Oral care with mothers' own milk was implemented as part of the VAP-prevention bundle in the neonatal intensive care unit in the fourth quarter of 2007. Using retrospective deidentified data retrieved from the electronic medical record, the primary and secondary outcome variables were collected among eligible infants (≤1500 g) admitted January 1, 2006, to December 31, 2007 (before implementation) and January 1, 2008, to December 31, 2009 (after implementation). Sample characteristics, including infant gestational age, birth weight, and gender, as well as maternal age, type of delivery, and incidence of maternal chorioamnionitis, were also collected. Data analysis included frequencies and distributions to summarize sample characteristics and variables of interest. Appropriate tests for differences were conducted on outcome variables between the before and after groups of the human milk oral care intervention. The feasibility outcome variable included nursing compliance with the oral care procedure. The safety outcome variable included record of any adverse events associated with the oral care procedure. The efficacy health outcomes included the rate of positive tracheal aspirates, positive blood cultures, the number of ventilator days, and length of stay. Infant age (26.1-26.6 weeks) and weight (840-863 g) were similar in the before (n = 70) and after (n = 68) sample subjects. There were no statistically significant differences in ventilator days, χ² (46, n = 115) = 46.22, P = .46, and length of stay, χ (75, n = 115) = 78.78, P = .36, between groups. Although the rate of positive tracheal aspirates and positive blood cultures reduced after implementation of oral care with mothers' own milk, these differences were not statistically significant (U(47) = 250, z = -7.1, P = .48; U(47) = 217.5, z = -1.44, P = .15). There were no statistically significant differences in the rates of positive tracheal aspirates and blood cultures after implementation of oral care with mothers' own milk. The findings of this study suggest that using mothers' own milk as part of the VAP-prevention bundle is a feasible and safe practice; however, further research is needed to determine the immunological benefits of this practice.

Speciated mercury at marine, coastal, and inland sites in New England - Part 1: Temporal variability

NASA Astrophysics Data System (ADS)

Mao, H.; Talbot, R.

2011-12-01

A comprehensive analysis was conducted using long-term continuous measurements of gaseous elemental mercury (Hgo), reactive mercury (RGM), and particulate phase mercury (HgP) at coastal (Thompson Farm, denoted as TF), marine (Appledore Island, denoted as AI), and elevated inland (Pac Monadnock, denoted as PM) sites from the AIRMAP Observatories. Decreasing trends in background Hgo were identified in the 7- and 5-yr records at TF and PM with decline rates of 3.3 parts per quadrillion by volume (ppqv) yr-1 and 6.3 ppqv yr-1, respectively. Common characteristics at these sites were the reproducible annual cycle of Hgo with its maximum in winter-spring and minimum in fall as well as a decline/increase trend in the warm/cool season. The coastal site TF differed from the other two sites with its exceptionally low levels (as low as below 50 ppqv) in the nocturnal inversion layer probably due to dissolution in dew water. Year-to-year variability was observed in the warm season decline in Hgo at TF varying from a minimum total seasonal loss of 20 ppqv in 2010 to a maximum of 92 ppqv in 2005, whereas variability remained small at AI and PM. Measurements of Hgo at PM, an elevated inland rural site, exhibited the smallest diurnal to annual variability among the three environments, where peak levels rarely exceeded 250 ppqv and the minimum was typically 100 ppqv. It should be noted that summertime diurnal patterns at TF and AI are opposite in phase indicating strong sink(s) for Hgo during the day in the marine boundary layer, which is consistent with the hypothesis of Hgo oxidation by halogen radicals there. Mixing ratios of RGM in the coastal and marine boundary layers reached annual maximum in spring and minimum in fall, whereas at PM levels were generally below the limit of detection (LOD) except in spring. RGM levels at AI were higher than at TF and PM indicating a stronger source strength(s) in the marine environment. Mixing ratios of HgP at AI and TF were close in magnitude to RGM levels and were mostly below 1 ppqv. Diurnal variation in HgP was barely discernible at TF and AI in spring and summer with higher levels during the day and smaller but above the LOD at night.

Metabolic and respiratory derangements associated with death in cold-stunned Kemp's ridley turtles (Lepidochelys kempii): 32 cases (2005-2009).

PubMed

Keller, Krista A; Innis, Charles J; Tlusty, Michael F; Kennedy, Adam E; Bean, Sarah B; Cavin, Julie M; Merigo, Constance

2012-02-01

To assess selected clinicopathologic variables at hospital admission (day 1) for cold-stunned Kemp's ridley turtles (Lepidochelys kempii) that died during the first 3 days after admission (nonsurvivors) and turtles that survived (survivors) and to determine the percentage change of each variable from day 1 to day of death (nonsurvivors) or to day 2 or 3 of hospitalization (survivors). Retrospective case-control study. Animals-64 stranded, cold-stunned Kemp's ridley turtles hospitalized from October 2005 through December 2009. Blood gas, pH, Hct, and selected biochemical values in blood samples determined on day 1 and day of death (nonsurvivors; n = 32) or day 2 or 3 of hospitalization (survivors; 32) were obtained from medical records. For each variable, initial values and percentage changes (from initial values to values at the day of death or day 2 or 3 of hospitalization) were compared between survivors and nonsurvivors. Compared with blood analysis findings for survivors, nonsurvivors initially had significantly higher potassium concentration and Pco(2) and significantly lower Po(2), pH, and bicarbonate concentration than did survivors. For the first 2 or 3 days of hospitalization, percentage changes in potassium, lactate, and ionized calcium concentrations were significantly higher and percentage changes in pH and plasma glucose and bicarbonate concentrations were significantly lower in nonsurvivors. At hospital admission, cold-stunned Kemp's ridley turtles were affected by metabolic and respiratory derangements; severe derangements were associated with death. Evaluation of blood gas, pH, Hct, and selected clinicopathologic variables provided useful clinical and prognostic information during rehabilitation of cold-stunned Kemp's ridley turtles.

Variability and Stability in Daily Moderate-to-Vigorous Physical Activity among 10 Year Old Children

PubMed Central

Pereira, Sara; Gomes, Thayse Natacha; Borges, Alessandra; Santos, Daniel; Souza, Michele; dos Santos, Fernanda K.; Chaves, Raquel N.; Katzmarzyk, Peter T.; Maia, José A. R.

2015-01-01

Day-to-day variability and stability of children’s physical activity levels across days of the week are not well understood. Our aims were to examine the day-to-day variability of moderate-to-vigorous physical activity (MVPA), to determine factors influencing the day-to-day variability of MVPA and to estimate stability of MVPA in children. The sample comprises 686 Portuguese children (10 years of age). MVPA was assessed with an accelerometer, and BMI was computed from measured height and weight. Daily changes in MVPA and their correlates (gender, BMI, and maturity) were modeled with a multilevel approach, and tracking was calculated using Foulkes & Davies γ. A total of 51.3% of boys and 26.2% of girls achieved 60 min/day of MVPA on average. Daily MVPA was lower during the weekend (23.6% of boys and 13.6% of girls comply with the recommended 60 min/day of MVPA) compared to weekdays (60.8% and 35.4%, boys and girls, respectively). Normal weight children were more active than obese children and no effect was found for biological maturation. Tracking is low in both boys (γ = 0.59 ± 0.01) and girls (γ = 0.56 ± 0.01). Children’s MVPA levels during a week are highly unstable. In summary, boys are more active than girls, maturation does not affect their MVPA, and obese children are less likely to meet 60 min/day of MVPA. These results highlight the importance of providing opportunities for increasing children’s daily MVPA on all days of week, especially on the weekend. PMID:26262632

Variability and Stability in Daily Moderate-to-Vigorous Physical Activity among 10 Year Old Children.

PubMed

Pereira, Sara; Gomes, Thayse Natacha; Borges, Alessandra; Santos, Daniel; Souza, Michele; dos Santos, Fernanda K; Chaves, Raquel N; Katzmarzyk, Peter T; Maia, José A R

2015-08-07

Day-to-day variability and stability of children's physical activity levels across days of the week are not well understood. Our aims were to examine the day-to-day variability of moderate-to-vigorous physical activity (MVPA), to determine factors influencing the day-to-day variability of MVPA and to estimate stability of MVPA in children. The sample comprises 686 Portuguese children (10 years of age). MVPA was assessed with an accelerometer, and BMI was computed from measured height and weight. Daily changes in MVPA and their correlates (gender, BMI, and maturity) were modeled with a multilevel approach, and tracking was calculated using Foulkes &amp; Davies γ. A total of 51.3% of boys and 26.2% of girls achieved 60 min/day of MVPA on average. Daily MVPA was lower during the weekend (23.6% of boys and 13.6% of girls comply with the recommended 60 min/day of MVPA) compared to weekdays (60.8% and 35.4%, boys and girls, respectively). Normal weight children were more active than obese children and no effect was found for biological maturation. Tracking is low in both boys (γ = 0.59 ± 0.01) and girls (γ = 0.56 ± 0.01). Children's MVPA levels during a week are highly unstable. In summary, boys are more active than girls, maturation does not affect their MVPA, and obese children are less likely to meet 60 min/day of MVPA. These results highlight the importance of providing opportunities for increasing children's daily MVPA on all days of week, especially on the weekend.

A multi-wavelength search for photometric variability in L dwarfs

NASA Astrophysics Data System (ADS)

Gelino, Christopher Ryan

Previous studies investigating L-dwarf variability have been conducted in the optical I filter. These studies have shown that some, but not all L dwarfs are variable in this filter. In this dissertation I increase the number of L dwarfs observed for variations in the I filter from 10 to 25, with another three from the original ten reexamined here. I find that at least 7 and possibly as many as 12 are variable. One of these variable objects has a puzzling saw-tooth pattern in part of its light curve and another displays a feature that could indicate the creation and dissipation of a large storm. There is no evidence for significant differences between the variable and non- variable objects in their colors, Hα emission, or Li I absorption. I argue that the lack of a correlation between Hα and variability, coupled with low magnetic Reynolds number and ionization fraction in the upper atmosphere, suggests a non-magnetic origin for the variations and favors non-uniform condensate coverage. Furthermore, the absence of significant periodicity in these objects could indicate that these clouds evolve rapidly on timescales of hours to days. In addition to the optical survey, I also present the first multi-wavelength near-infrared search for photometric variations in L dwarfs. I was unable to detect any definite variability in these eleven targets. The upper limits for the amplitude of possible variations suggest that L dwarfs display smaller variations in K than in J and H . The small number of objects on which this conclusion is based and the lack of variability detections underscores the importance of more work in this wavelength regime.

Wave Coupling between the Lower and Middle Thermosphere as Viewed from Quasi-Sun-Synchronous Satellites

NASA Astrophysics Data System (ADS)

Gasperini, Federico

In a society increasingly dependent on space technology, space weather has become a prominent scientific paradigm. In the last decade evidence has shown that terrestrial weather significantly influences space weather. Periodic absorption of solar radiation in local time and longitude by tropospheric water vapor and stratospheric ozone as well as latent heat release in clouds generate a spatially- and temporally-evolving spectrum of global-scale atmospheric waves (i.e., tides, planetary waves and Kelvin waves). A subset of these waves propagates vertically, evolving with height due to wave-mean flow, wave-wave, and wave-plasma interactions, and driving electric fields of tidal origin in the dynamo region. While considerable improvements have been made on the understanding of MLT dynamics, driven in part by the development and deployment of new instruments and techniques, relatively little is known about the coupling of waves in the 120-300 km `thermospheric gap' between satellite remote-sensing and in-situ wave diagnostics. The dissertation herein reveals vertical wave coupling in this height region and quantifies its role in determining thermospheric variability. This objective is accomplished employing quasi-Sun-synchronous satellite measurements (i.e., TIMED, CHAMP, and GOCE) and state-of-the-art numerical modeling simulations (i.e., TIME-GCM/MERRA). Evidence is found for the vertical propagation from the lower to the middle thermosphere of the eastward propagating diurnal tide with zonal wave number 3 (DE3) and the 3-day ultra-fast Kelvin wave (UFKW), two major global-scale atmospheric oscillations of tropospheric origin. These waves are shown to nonlinearly interact and produce secondary waves responsible for significant longitudinal and day-to-day variability. For solar and geomagnetic quiet conditions, atmospheric waves are found to be responsible for up to 60% of the total variability, demonstrating lower atmosphere coupling as a key contributor to thermosphere weather, at least in the absence of major solar-driven variability. Additionally, background atmospheric conditions (i.e., dissipation and zonal mean winds) and found to significantly impact the latitudinal-temporal evolution of upward propagating waves.

The Importance of Rotational Time-scales in Accretion Variability

NASA Astrophysics Data System (ADS)

Costigan, Gráinne; Vink, Joirck; Scholz, Aleks; Testi, Leonardo; Ray, Tom

2013-07-01

For the first few million years, one of the dominant sources of emission from a low mass young stellar object is from accretion. This process regulates the flow of material and angular moments from the surroundings to the central object, and is thought to play an important role in the definition of the long term stellar properties. Variability is a well documented attribute of accretion, and has been observed on time-scales of from days to years. However, where these variations come from is not clear. Th current model for accretion is magnetospheric accretion, where the stellar magnetic field truncates the disc, allowing the matter to flow from the disc onto the surface of the star. This model allows for variations in the accretion rate to come from many different sources, such as the magnetic field, the circumstellar disc and the interaction of the different parts of the system. We have been studying unbiased samples of accretors in order to identify the dominant time-scales and typical magnitudes of variations. In this way different sources of variations can be excluded and any missing physics in these systems identified. Through our previous work with the Long-term Accretion Monitoring Program (LAMP), we found 10 accretors in the ChaI region, whose variability is dominated by short term variations of 2 weeks. This was the shortest time period between spectroscopic observations which spanned 15 months, and rules out large scale processes in the disk as origins of this variability. On the basis of this study we have gone further to study the accretion signature H-alpha, over the time-scales of minutes and days in a set of Herbig Ae and T Tauri stars. Using the same methods as we used in LAMP we found the dominant time-scales of variations to be days. These samples both point towards rotation period of these objects as being an important time-scale for accretion variations. This allows us to indicate which are the most likely sources of these variations.

Paired variability indices in assessing speech rhythm in Spanish/English bilingual language acquisition

NASA Astrophysics Data System (ADS)

Work, Richard; Andruski, Jean; Casielles, Eugenia; Kim, Sahyang; Nathan, Geoff

2005-04-01

Traditionally, English is classified as a stress-timed language while Spanish is classified as syllable-timed. Examining the contrasting development of rhythmic patterns in bilingual first language acquisition should provide information on how this differentiation takes place. As part of a longitudinal study, speech samples were taken of a Spanish/English bilingual child of Argentinean parents living in the Midwestern United States between the ages of 1;8 and 3;2. Spanish is spoken at home and English input comes primarily from an English day care the child attends 5 days a week. The parents act as interlocutors for Spanish recordings with a native speaker interacting with the child for the English recordings. Following the work of Grabe, Post and Watson (1999) and Grabe and Low (2002) a normalized Pairwise Variability Index (PVI) is used which compares, in utterances of minimally four syllables, the durations of vocalic intervals in successive syllables. Comparisons are then made between the rhythmic patterns of the child's productions within each language over time and between languages at comparable MLUs. Comparisons are also made with the rhythmic patterns of the adult productions of each language. Results will be analyzed for signs of native speaker-like rhythmic production in the child.

Individual aptitude in Mandarin lexical tone perception predicts effectiveness of high-variability training

PubMed Central

Sadakata, Makiko; McQueen, James M.

2014-01-01

Although the high-variability training method can enhance learning of non-native speech categories, this can depend on individuals’ aptitude. The current study asked how general the effects of perceptual aptitude are by testing whether they occur with training materials spoken by native speakers and whether they depend on the nature of the to-be-learned material. Forty-five native Dutch listeners took part in a 5-day training procedure in which they identified bisyllabic Mandarin pseudowords (e.g., asa) pronounced with different lexical tone combinations. The training materials were presented to different groups of listeners at three levels of variability: low (many repetitions of a limited set of words recorded by a single speaker), medium (fewer repetitions of a more variable set of words recorded by three speakers), and high (similar to medium but with five speakers). Overall, variability did not influence learning performance, but this was due to an interaction with individuals’ perceptual aptitude: increasing variability hindered improvements in performance for low-aptitude perceivers while it helped improvements in performance for high-aptitude perceivers. These results show that the previously observed interaction between individuals’ aptitude and effects of degree of variability extends to natural tokens of Mandarin speech. This interaction was not found, however, in a closely matched study in which native Dutch listeners were trained on the Japanese geminate/singleton consonant contrast. This may indicate that the effectiveness of high-variability training depends not only on individuals’ aptitude in speech perception but also on the nature of the categories being acquired. PMID:25505434

A randomized, double-blind, placebo-controlled crossover study of the effects of levetiracetam on cognition, mood, and balance in healthy older adults.

PubMed

Schoenberg, Mike R; Rum, Ruba S; Osborn, Katie E; Werz, Mary Ann

2017-09-01

The cognitive and mood effects of levetiracetam (LEV) in older adults are not known. This study compared the cognitive and mood effects of LEV to placebo in healthy older adults. Cognitive, mood, and balance variables were compared between LEV and placebo using a randomized, double-blind, placebo-controlled crossover study with two 5-week treatment periods. Healthy volunteers (n = 20) aged 65-80 (mean age 72.4) received either LEV or placebo in which the LEV target dose was 1,000 mg/day. Volunteers, aged 65-80, were without epilepsy to limit potentially confounding the impact of seizures and/or underlying neuropathology on outcomes. LEV was initiated at 250 mg twice a day for 2 weeks, then increased to 500 mg twice a day for 2 weeks, and then tapered to 250 mg twice a day for 1 week. This was randomized with placebo for the two treatment arms. Measures included standardized neuropsychological, mood, and balance tests yielding 32 variables. Balance was assessed using subjective report (e.g., A-B neurotoxicity scale) and objective data (e.g., Berg Balance Scale). Average LEV serum concentration was 16.9 (standard deviation [SD} 7.7). Repeated-measures analysis of variance (ANOVA) found no differences between LEV and placebo phases for 29 (90.6%) of 32 variables including no change in balance. Performance on LEV was better than placebo on a visual memory (MCG Complex Figure Recall; p = 0.007) and two attention tests (Trail Making Test, Part A, p = 0.009; Stroop Interference, p = 0.004). There was a trend for greater irritability and fatigue (POMS Anger and Fatigue) during the LEV phase (p = 0.029, p = 0.035). Effect-size changes were generally small (Cohen d < 0.5). LEV was well tolerated in this elderly population in terms of cognition, mood, and balance. When anticonvulsant medication is indicated for older adults, LEV has pharmacokinetic advantages, and these data indicate no adverse impact on cognition or balance. Wiley Periodicals, Inc. © 2017 International League Against Epilepsy.

Harmonize input selection for sediment transport prediction

NASA Astrophysics Data System (ADS)

Afan, Haitham Abdulmohsin; Keshtegar, Behrooz; Mohtar, Wan Hanna Melini Wan; El-Shafie, Ahmed

2017-09-01

In this paper, three modeling approaches using a Neural Network (NN), Response Surface Method (RSM) and response surface method basis Global Harmony Search (GHS) are applied to predict the daily time series suspended sediment load. Generally, the input variables for forecasting the suspended sediment load are manually selected based on the maximum correlations of input variables in the modeling approaches based on NN and RSM. The RSM is improved to select the input variables by using the errors terms of training data based on the GHS, namely as response surface method and global harmony search (RSM-GHS) modeling method. The second-order polynomial function with cross terms is applied to calibrate the time series suspended sediment load with three, four and five input variables in the proposed RSM-GHS. The linear, square and cross corrections of twenty input variables of antecedent values of suspended sediment load and water discharge are investigated to achieve the best predictions of the RSM based on the GHS method. The performances of the NN, RSM and proposed RSM-GHS including both accuracy and simplicity are compared through several comparative predicted and error statistics. The results illustrated that the proposed RSM-GHS is as uncomplicated as the RSM but performed better, where fewer errors and better correlation was observed (R = 0.95, MAE = 18.09 (ton/day), RMSE = 25.16 (ton/day)) compared to the ANN (R = 0.91, MAE = 20.17 (ton/day), RMSE = 33.09 (ton/day)) and RSM (R = 0.91, MAE = 20.06 (ton/day), RMSE = 31.92 (ton/day)) for all types of input variables.

Association of Day Length and Weather Conditions with Physical Activity Levels in Older Community Dwelling People

PubMed Central

Witham, Miles D.; Donnan, Peter T.; Vadiveloo, Thenmalar; Sniehotta, Falko F.; Crombie, Iain K.; Feng, Zhiqiang; McMurdo, Marion E. T.

2014-01-01

Background Weather is a potentially important determinant of physical activity. Little work has been done examining the relationship between weather and physical activity, and potential modifiers of any relationship in older people. We therefore examined the relationship between weather and physical activity in a cohort of older community-dwelling people. Methods We analysed prospectively collected cross-sectional activity data from community-dwelling people aged 65 and over in the Physical Activity Cohort Scotland. We correlated seven day triaxial accelerometry data with daily weather data (temperature, day length, sunshine, snow, rain), and a series of potential effect modifiers were tested in mixed models: environmental variables (urban vs rural dwelling, percentage of green space), psychological variables (anxiety, depression, perceived behavioural control), social variables (number of close contacts) and health status measured using the SF-36 questionnaire. Results 547 participants, mean age 78.5 years, were included in this analysis. Higher minimum daily temperature and longer day length were associated with higher activity levels; these associations remained robust to adjustment for other significant associates of activity: age, perceived behavioural control, number of social contacts and physical function. Of the potential effect modifier variables, only urban vs rural dwelling and the SF-36 measure of social functioning enhanced the association between day length and activity; no variable modified the association between minimum temperature and activity. Conclusions In older community dwelling people, minimum temperature and day length were associated with objectively measured activity. There was little evidence for moderation of these associations through potentially modifiable health, environmental, social or psychological variables. PMID:24497925

Association of day length and weather conditions with physical activity levels in older community dwelling people.

PubMed

Witham, Miles D; Donnan, Peter T; Vadiveloo, Thenmalar; Sniehotta, Falko F; Crombie, Iain K; Feng, Zhiqiang; McMurdo, Marion E T

2014-01-01

Weather is a potentially important determinant of physical activity. Little work has been done examining the relationship between weather and physical activity, and potential modifiers of any relationship in older people. We therefore examined the relationship between weather and physical activity in a cohort of older community-dwelling people. We analysed prospectively collected cross-sectional activity data from community-dwelling people aged 65 and over in the Physical Activity Cohort Scotland. We correlated seven day triaxial accelerometry data with daily weather data (temperature, day length, sunshine, snow, rain), and a series of potential effect modifiers were tested in mixed models: environmental variables (urban vs rural dwelling, percentage of green space), psychological variables (anxiety, depression, perceived behavioural control), social variables (number of close contacts) and health status measured using the SF-36 questionnaire. 547 participants, mean age 78.5 years, were included in this analysis. Higher minimum daily temperature and longer day length were associated with higher activity levels; these associations remained robust to adjustment for other significant associates of activity: age, perceived behavioural control, number of social contacts and physical function. Of the potential effect modifier variables, only urban vs rural dwelling and the SF-36 measure of social functioning enhanced the association between day length and activity; no variable modified the association between minimum temperature and activity. In older community dwelling people, minimum temperature and day length were associated with objectively measured activity. There was little evidence for moderation of these associations through potentially modifiable health, environmental, social or psychological variables.

42 CFR 423.40 - Effective dates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... day of the calendar month following the month in which the enrollment in Part D is made. (3) If the individual is not eligible to enroll in Part D on the first day of the calendar month following the month in which the election to enroll in Part D is made, the enrollment in Part D is effective the first day of...

An In-Depth Study of the Four-Day College Week. Part I; The Four-Day College Week: Revolution or Evolution. Part II; A Survey of Common Practices of Texas Colleges Utilizing the Four-Day College Week.

ERIC Educational Resources Information Center

Riley, Bob E.

This two-part report discusses the implementation of the four-day week on college campuses and summarizes the results of a survey conducted to investigate: (1) the history of the four-day college week in Texas; (2) how Texas colleges using this system integrate their operations into the four-day week; and (3) the future acceptance of the four-day…

Seasonal and diurnal variability in airborne mold from an indoor residential environment in northern New York.

PubMed

LeBouf, Ryan; Yesse, Liesel; Rossner, Alan

2008-05-01

It is well known that characterization of airborne bioaerosols in indoor environments is a challenge because of inherent irregularity in concentrations, which are influenced by many environmental factors. The primary aim of this study was to quantify the day-to-day variability of airborne fungal levels in a single residential environment over multiple seasons. Indoor air quality practitioners must recognize the inherent variability in airborne bio-aerosol measurements during data analysis of mold investigations. Changes in airborne fungi due to varying season and day is important to recognize when considering health impacts of these contaminants and when establishing effective controls. Using an Andersen N6 impactor, indoor and outdoor bioaerosol samples were collected on malt extract agar plates for 18 weekdays and 19 weekdays in winter and summer, respectively. Interday and intraday variability for the bioaerosols were determined for each sampler. Average fungal concentrations were 26 times higher during the summer months. Day-to-day fungal samples showed a relatively high inconsistency suggesting airborne fungal levels are very episodic and are influenced by several environmental factors. Summer bio-aerosol variability ranged from 7 to 36% and winter variability from 24 to 212%; these should be incorporated into results of indoor mold investigations. The second objective was to observe the relationship between biological and nonbiological particulate matter (PM). No correlation was observed between biological and nonbiological PM. Six side-by-side particulate samplers collected coarse PM (PM10) and fine PM (PM2.5) levels in both seasons. PM2.5 particulate concentrations were found to be statistically higher during summer months. Interday variability observed during this study suggests that indoor air quality practitioners must adjust their exposure assessment strategies to reflect the temporal variability in bioaerosol concentrations.

Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: the Ohasama study.

PubMed

Satoh, Michihiro; Hosaka, Miki; Asayama, Kei; Kikuya, Masahiro; Inoue, Ryusuke; Metoki, Hirohito; Tsubota-Utsugi, Megumi; Hara, Azusa; Hirose, Takuo; Obara, Taku; Totsune, Kazuhito; Hoshi, Haruhisa; Mano, Nariyasu; Node, Koichi; Imai, Yutaka; Ohkubo, Takayoshi

2015-08-01

In addition to day-to-day variability in blood pressure (BP) or heart rate (HR), N-terminal pro B-type natriuretic peptide (NT-proBNP) has been reported to be a predictor of cardiovascular disease. Here, we tested the hypothesis that day-to-day BP or HR variability calculated as the intraindividual standard deviation (SD) of home BP or HR is associated with elevated NT-proBNP in a cross-sectional study. Among 664 participants (mean age, 61.9 years; female, 70.5%) from a general Japanese population without a history of heart disease, 86 (13.0%) had NT-proBNP at least 125 pg/ml. Each 1 SD increase in the SD of home systolic BP (SBP) [odds ratio (OR), 1.82; P < .0001) and in the SD of home HR (OR, 1.44; P = 0.008) were significantly associated with the prevalence of NT-proBNP at least 125 pg/ml after adjustment for possible confounding factors including home SBP and HR. Among the four groups defined by the median SD of home SBP and of home HR, the group with higher SDs in home SBP (≥8.0 mmHg) and HR (≥5.0 bpm) had the greatest OR for the prevalence of NT-proBNP at least 125 pg/ml (OR, 4.80; P = 0007 vs. a reference group with lower SDs of home SBP and HR). These results suggest that day-to-day variability in BP and HR may be associated with target-organ damage or complications, which can lead to an elevated NT-proBNP level. An elevated NT-proBNP level may be involved in the prognostic significance of day-to-day variability in BP or HR.

Clinical Variables Associated with Hydration Status in Acute Ischemic Stroke Patients with Dysphagia.

PubMed

Crary, Michael A; Carnaby, Giselle D; Shabbir, Yasmeen; Miller, Leslie; Silliman, Scott

2016-02-01

Acute stroke patients with dysphagia are at increased risk for poor hydration. Dysphagia management practices may directly impact hydration status. This study examined clinical factors that might impact hydration status in acute ischemic stroke patients with dysphagia. A retrospective chart review was completed on 67 ischemic stroke patients who participated in a prior study of nutrition and hydration status during acute care. Prior results indicated that patients with dysphagia demonstrated elevated BUN/Cr compared to non-dysphagia cases during acute care and that BUN/Cr increased selectively in dysphagic patients. This chart review evaluated clinical variables potentially impacting hydration status: diuretics, parenteral fluids, tube feeding, oral diet, and nonoral (NPO) status. Exposure to any variable and number of days of exposure to each variable were examined. Dysphagia cases demonstrated significantly more NPO days, tube fed days, and parenteral fluid days, but not oral fed days, or days on diuretics. BUN/Cr values at discharge were not associated with NPO days, parenteral fluid days, oral fed days, or days on diuretics. Patients on modified solid diets had significantly higher mean BUN/Cr values at discharge (27.12 vs. 17.23) as did tube fed patients (28.94 vs. 18.66). No difference was noted between these subgroups at baseline (regular diet vs. modified solids diets). Any modification of solid diets (31.11 vs. 17.23) or thickened liquids (28.50 vs. 17.81) resulted in significantly elevated BUN/Cr values at discharge. Liquid or diet modifications prescribed for acute stroke patients with dysphagia may impair hydration status in these patients.

Effects of multiple ascending doses of the glucagon receptor antagonist PF-06291874 in patients with type 2 diabetes mellitus.

PubMed

Kazierad, D J; Bergman, A; Tan, B; Erion, D M; Somayaji, V; Lee, D S; Rolph, T

2016-08-01

To assess the pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of the glucagon receptor antagonist PF-06291874 in patients with type 2 diabetes mellitus (T2DM). Patients were randomized to oral PF-06291874 or placebo on a background of either metformin (Part A, Cohorts 1-5: 5-150 mg once daily), or metformin and sulphonylurea (Part B, Cohorts 1-2: 15 or 30 mg once daily) for 14-28 days. A mixed-meal tolerance test (MMTT) was administered on days -1 (baseline), 14 and 28. Assessments were conducted with regard to pharmacokinetics, various pharmacodynamic variables, safety and tolerability. Circulating amino acid concentrations were also measured. PF-06291874 exposure was approximately dose-proportional with a half-life of ∼19.7-22.7 h. Day 14 fasting plasma glucose and mean daily glucose values were reduced from baseline in a dose-dependent manner, with placebo-corrected decreases of 34.3 and 42.4 mg/dl, respectively, at the 150 mg dose. After the MMTT, dose-dependent increases in glucagon and total glucagon-like peptide-1 (GLP-1) were observed, although no meaningful changes were noted in insulin, C-peptide or active GLP-1 levels. Small dose-dependent increases in LDL cholesterol were observed, along with reversible increases in serum aminotransferases that were largely within the laboratory reference range. An increase in circulating gluconeogenic amino acids was also observed on days 2 and 14. All dose levels of PF-06291874 were well tolerated. PF-06291874 was well tolerated, has a pharmacokinetic profile suitable for once-daily dosing, and results in reductions in glucose with minimal risk of hypoglycaemia. © 2016 John Wiley & Sons Ltd.

The Continuing Search for Variability Among Cool White Dwarfs

NASA Astrophysics Data System (ADS)

Schaefer, J. J.; Oswalt, T. D.; Johnston, K. B.; Rudkin, M.; Heinz, T.

2002-12-01

The Continuing Search for Variability Among Cool White Dwarfs Justin J. Schaefer University of Wyoming Department of Physics and Astronomy P.O. Box 3905 Laramie, Wyoming 82071 USA (schaefju@uwyo.edu) Terry D. Oswalt, Kyle Johnston, Merissa Rudkin, Tamalyn Heinz Florida Institute of Technology and the SARA Observatory Department of Physics & Space Sciences 150 West University Boulevard Melbourne, Florida 32901 USA (oswalt@luyten.astro.fit.edu, kyjohnst@fit.edu, mrudkin@astro.fit.edu, theinz@fit.edu) ABSTRACT We present BVRI photometry of eleven binaries with white dwarf (WD) components. The observations were obtained at the SARA 0.9-meter telescope on Kitt Peak during the summer of 2002. Standard system (B-V), (V-R) and (R-I) color indices of four white dwarfs were determined. This data will be used to estimate the WD cooling ages in wide WD+dM binaries, as part of our ongoing research program to determine the chromospheric activity-age relation for M dwarf stars. Time-series differential photometry was also collected for eight cool white dwarfs as part of a program to explore the variability in the low luminosity, low temperature regime of the WD cooling track. We failed to detect any variability greater than ~0.04 magnitudes in these stars. Several nights of differential photometry data were collected on the DAO WD + K dwarf short-period variable HS1136+6646. From the light variations we determined a likely orbital period of 0.825 +/-0.009 days. Strong evidence is presented for two other possible periods within this light curve, possibly indicative of rotational modulation by the WD component. We gratefully acknowledge support from the National Science Foundation, which funds the SARA Research Experiences for Undergraduates program via grant AST-0097616 to Florida Tech. One of us (TDO) also acknowledges partial support for this work from NASA (subcontract Y701296) and the NSF (AST 0206115).

Long-term and within-day variability of working memory performance and EEG in individuals.

PubMed

Gevins, Alan; McEvoy, Linda K; Smith, Michael E; Chan, Cynthia S; Sam-Vargas, Lita; Baum, Cliff; Ilan, Aaron B

2012-07-01

Assess individual-subject long-term and within-day variability of a combined behavioral and EEG test of working memory. EEGs were recorded from 16 adults performing n-back working memory tasks, with 10 tested in morning and afternoon sessions over several years. Participants were also tested after ingesting non-prescription medications or recreational substances. Performance and EEG measures were analyzed to derive an Overall score and three constituent sub-scores characterizing changes in performance, cortical activation, and alertness from each individual's baseline. Long-term and within-day variability were determined for each score; medication effects were assessed by reference to each individual's normal day-to-day variability. Over the several year period, the mean Overall score and sub-scores were approximately zero with standard deviations less than one. Overall scores were lower and their variability higher in afternoon relative to morning sessions. At the group level, alcohol, diphenhydramine and marijuana produced significant effects, but there were large individual differences. Objective working memory measures incorporating performance and EEG are stable over time and sensitive at the level of individual subjects to interventions that affect neurocognitive function. With further research these measures may be suitable for use in individualized medical care by providing a sensitive assessment of incipient illness and response to treatment. Published by Elsevier Ireland Ltd.

Assessment of exposure to manganese in welding operations during the assembly of heavy excavation machinery accessories.

PubMed

Smargiassi, A; Baldwin, M; Savard, S; Kennedy, G; Mergler, D; Zayed, J

2000-10-01

Welder exposure to metals in various industrial sectors is poorly characterized. We had the opportunity to carry out an exploratory study to characterize manganese exposure in welding operations in a recently established Quebec factory that assembled accessories for heavy excavation machinery. Ten workers were sampled for total manganese for at least two consecutive days out of three followed by two consecutive days for respirable manganese (with a size selective sampler with a median cut-off of 4 microns), during a typical week in the summer of 1998. Parts being welded were characterized as large or small. Small parts were those being welded on tables during subassembly. Workers were divided into two groups according to the parts they were welding. Seventy-eight percent of the total manganese exposure levels of welding operations during the assembly of large accessories of heavy excavation machinery exceeded the manganese American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value (TLV) of 0.20 mg/m3 (GM 0.24 mg/m3, n = 14) while none exceeded the TLV during the assembly of small pieces (GM 0.06 mg/m3, n = 8). Welding operations during the assembly of large heavy excavation machinery accessories may pose a significant health hazard. Considering the importance of task-related variables affecting exposure among workers, further studies are needed to better characterize exposure determinants of welding operations during the assembly of heavy excavation machinery accessories.

Spatial and temporal variability of cv. Tempranillo phenology and grape quality within the Ribera del Duero DO (Spain) and relationships with climate.

PubMed

Ramos, M C; Jones, G V; Yuste, J

2015-12-01

The aim of this work was to analyze spatial phenology and grape quality variability related to the climatic characteristics within the Ribera del Duero Designation of Origin (DO). Twenty plots planted with cv. Tempranillo and distributed within the DO were analyzed for phenology from 2004 to 2013. Grape quality parameters at ripening (berry weight, sugar content, acidity and pH, and anthocyanins) were analyzed in 26 plots for the period 2003-2013. The relationships between phenology and grape parameters with different climatic variables were confirmed with a multivariate analysis. On average, bud break was April 27(th), bloom June 17(th), and veraison August 12th. However, phenology during the time period showed high variability, with differences between years of up to 21 days for a phenology stage. The earliest dates were observed in dry years (2005, 2006, and to a lesser degree in 2009) while the later phenology dates occurred in the wettest year of the period (2008). High correlations were found between veraison date and temperature variables as well as with precipitation-evapotranspiration recorded during the bloom-veraison period. These effects tended to be higher in the central part of the DO. Grape quality parameters also showed high variability among the dry and the wet years, and the influence of extreme temperatures on color development as well as the effect of available water on acidity were observed.

Spatial and temporal variability of cv. Tempranillo phenology and grape quality within the Ribera del Duero DO (Spain) and relationships with climate

NASA Astrophysics Data System (ADS)

Ramos, M. C.; Jones, G. V.; Yuste, J.

2015-12-01

The aim of this work was to analyze spatial phenology and grape quality variability related to the climatic characteristics within the Ribera del Duero Designation of Origin (DO). Twenty plots planted with cv. Tempranillo and distributed within the DO were analyzed for phenology from 2004 to 2013. Grape quality parameters at ripening (berry weight, sugar content, acidity and pH, and anthocyanins) were analyzed in 26 plots for the period 2003-2013. The relationships between phenology and grape parameters with different climatic variables were confirmed with a multivariate analysis. On average, bud break was April 27th, bloom June 17th, and veraison August 12th. However, phenology during the time period showed high variability, with differences between years of up to 21 days for a phenology stage. The earliest dates were observed in dry years (2005, 2006, and to a lesser degree in 2009) while the later phenology dates occurred in the wettest year of the period (2008). High correlations were found between veraison date and temperature variables as well as with precipitation-evapotranspiration recorded during the bloom-veraison period. These effects tended to be higher in the central part of the DO. Grape quality parameters also showed high variability among the dry and the wet years, and the influence of extreme temperatures on color development as well as the effect of available water on acidity were observed.

Interferometric Synthetic Aperture Radar to capture spatial variability of local land-based subsidence

NASA Astrophysics Data System (ADS)

Bekaert, D. P.; Hamlington, B.; Buzzanga, B. A.; Jones, C. E.

2017-12-01

The rate of relative sea level rise results from a combination of land subsidence and rising seas associated with global warming on long timescales and exacerbated by shifts in ocean dynamics on shorter timescales. An understanding of the current-day magnitude of each component is needed to create accurate projections of future relative sea level rise upon which to base planning efforts. Current day land-based subsidence rates derived from GPS often lack the spatial resolution to capture the local spatial variability needed when assessing the impact of relative sea-level rise. Interferometric Synthetic Aperture Radar (InSAR) is an attractive technique that has the potential to provide a measurement every 20-30m when good signal coherence is maintained. In practice, coastal regions are challenging for InSAR due to variable vegetation cover and soil moisture, which can be in part mitigated by applying advanced time-series InSAR techniques. After applying time-series InSAR, derived rates need to be combined with GPS to tie relative subsidence rates into a geodetic reference frame. Given the need to make projections of relative sea-level rise it is particularly important to propagate all uncertainties during the different processing stages. Here we provide results from ALOS and Sentinel-1 over Hampton Roads area in the Chesapeake Bay region, which is experiencing one of the highest rates of relative sea level rise on the Atlantic coast of the United States. Although the current derived subsidence rates have large uncertainties, it is expected that this will improve with the decadal observations from Sentinel-1.

Patterns of and Motivations for Concurrent Use of Video Games and Substances

PubMed Central

Ream, Geoffrey L.; Elliott, Luther C.; Dunlap, Eloise

2011-01-01

“Behavioral addictions” share biological mechanisms with substance dependence, and “drug interactions” have been observed between certain substances and self-reinforcing behaviors. This study examines correlates of patterns of and motivations for playing video games while using or feeling the effects of a substance (concurrent use). Data were drawn from a nationally-representative survey of adult Americans who “regularly” or “occasionally” played video games and had played for at least one hour in the past seven days (n = 3,380). Only recent concurrent users’ data were included in analyses (n = 1,196). Independent variables included demographics, substance use frequency and problems, game genre of concurrent use (identified by looking titles up in an industry database), and general game playing variables including problem video game play (PVP), consumer involvement, enjoyment, duration, and frequency of play. Exploratory factor analysis identified the following dimensions underlying patterns of and motivations for concurrent use: pass time or regulate negative emotion, enhance an already enjoyable or positive experience, and use of video games and substances to remediate each other’s undesirable effects. Multivariate regression analyses indicated PVP and hours/day of video game play were associated with most patterns/motivations, as were caffeine, tobacco, alcohol, marijuana, and painkiller use problems. This suggests that concurrent use with some regular situational pattern or effect-seeking motivation is part of the addictive process underlying both PVP and substance dependence. Various demographic, game playing, game genre of concurrent use, and substance use variables were associated with specific motivations/patterns, indicating that all are important in understanding concurrent use. PMID:22073024

Dynamic linear models to explore time-varying suspended sediment-discharge rating curves

NASA Astrophysics Data System (ADS)

Ahn, Kuk-Hyun; Yellen, Brian; Steinschneider, Scott

2017-06-01

This study presents a new method to examine long-term dynamics in sediment yield using time-varying sediment-discharge rating curves. Dynamic linear models (DLMs) are introduced as a time series filter that can assess how the relationship between streamflow and sediment concentration or load changes over time in response to a wide variety of natural and anthropogenic watershed disturbances or long-term changes. The filter operates by updating parameter values using a recursive Bayesian design that responds to 1 day-ahead forecast errors while also accounting for observational noise. The estimated time series of rating curve parameters can then be used to diagnose multiscale (daily-decadal) variability in sediment yield after accounting for fluctuations in streamflow. The technique is applied in a case study examining changes in turbidity load, a proxy for sediment load, in the Esopus Creek watershed, part of the New York City drinking water supply system. The results show that turbidity load exhibits a complex array of variability across time scales. The DLM highlights flood event-driven positive hysteresis, where turbidity load remained elevated for months after large flood events, as a major component of dynamic behavior in the rating curve relationship. The DLM also produces more accurate 1 day-ahead loading forecasts compared to other static and time-varying rating curve methods. The results suggest that DLMs provide a useful tool for diagnosing changes in sediment-discharge relationships over time and may help identify variability in sediment concentrations and loads that can be used to inform dynamic water quality management.

Two-Decade Monitoring of MWC349 in Optical and Radio: New Results

NASA Astrophysics Data System (ADS)

Thomashow, Eydon; Jorgenson, Regina A.; Strelnitski, Vladimir; Walker, Gary; Maria Mitchell Observatory (MMO) Research Experiences for Undergraduate (REU) Interns, 2017

2018-01-01

Maria Mitchell Observatory (MMO) has completed the two-decade long monitoring of MWC 349 in the optical and radio domains. This poster presentation will be primarily devoted to the new results obtained by optical photometry with broad and narrow band filters and observations of the variability in the masing H30 radio line during the observational season of 2017. The H30 emission arises in the circumstellar disk of the MWC 349A component of the visual double star (with 2.4 arcsec separation between the A and B components). Variable optical emission is also believed to be due to star A. By combining our optical observations with earlier MMO observations, we not only confirmed the previously known quasi-period of ~230 days, but confirmed a second period of ~700 days. One of the most interesting results of radio monitoring is the long-term variability of the systemic radial velocity of star A, as determined through averaging the radial velocities of the two masing peaks arising in the circumstellar disk. This may be the first case where a possible hidden close companion of a star (a lower mass star or a massive protoplanet) is detected by monitoring the radial velocity of the star via the spectral line radiation from its disk. E.T. completed this project as a 2017 MMO NSF REU intern and would like to thank the other interns for their help in conducting the optical observations. This project was supported in part by the NSF REU grant AST-1358980 and by the Nantucket Maria Mitchell Association.

Does the social gradient remain in the dietary habits of a health-conscious population? A study of Seventh-Day Adventists in West Malaysia.

PubMed

Tan, Min Min; Chan, Carina K Y; Reidpath, Daniel D

2017-12-01

Socioeconomic status (SES) is a strong predictor of health, and individuals with higher SES generally have better health than those with lower SES. One of the pathways that SES influences health is through health behaviors, such as dietary intake, and a higher SES has been associated with a better diet. The purpose of this study was to determine whether there was a social gradient in dietary habits among the Seventh-Day Adventists, a group of conservative Christians, where healthy eating is part of the doctrinal teaching. Data from a survey of 574 Adventists residing in West Malaysia, aged 18-80 years, were analyzed. Dietary habits were measured using the Nutrition subscale of Health Promoting Lifestyle Profile II. Education and income were significantly associated with dietary habits before and after controlling for demographics. There was a gradient of association; a higher level of education and higher income were associated with better dietary habits. However, only education remained significantly associated with dietary habits when the other two socioeconomic variables were included. Employment was not significantly associated with dietary habits before or after controlling for demographic variables and the other two sociodemographic variables. This study showed that education is the strongest predictor of healthy diet, and a social gradient in dietary habits still exists even among health-conscious population. © The Author 2016. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Patterns of and motivations for concurrent use of video games and substances.

PubMed

Ream, Geoffrey L; Elliott, Luther C; Dunlap, Eloise

2011-10-01

"Behavioral addictions" share biological mechanisms with substance dependence, and "drug interactions" have been observed between certain substances and self-reinforcing behaviors. This study examines correlates of patterns of and motivations for playing video games while using or feeling the effects of a substance (concurrent use). Data were drawn from a nationally-representative survey of adult Americans who "regularly" or "occasionally" played video games and had played for at least one hour in the past seven days (n = 3,380). Only recent concurrent users' data were included in analyses (n = 1,196). Independent variables included demographics, substance use frequency and problems, game genre of concurrent use (identified by looking titles up in an industry database), and general game playing variables including problem video game play (PVP), consumer involvement, enjoyment, duration, and frequency of play. Exploratory factor analysis identified the following dimensions underlying patterns of and motivations for concurrent use: pass time or regulate negative emotion, enhance an already enjoyable or positive experience, and use of video games and substances to remediate each other's undesirable effects. Multivariate regression analyses indicated PVP and hours/day of video game play were associated with most patterns/motivations, as were caffeine, tobacco, alcohol, marijuana, and painkiller use problems. This suggests that concurrent use with some regular situational pattern or effect-seeking motivation is part of the addictive process underlying both PVP and substance dependence. Various demographic, game playing, game genre of concurrent use, and substance use variables were associated with specific motivations/patterns, indicating that all are important in understanding concurrent use.

Variations in the reproductive cycle of Dreissena polymorpha in Europe, Russia, and North America

USGS Publications Warehouse

Nichols, Susan Jerrine

1996-01-01

The reproductive cycle of the zebra mussel (Dreissena polymorpha) is highly variable throughout its range in Europe, Russia, and North America. The environmental factors influencing this variation are poorly understood, but successful reproduction is occurring in areas where it was initially believed that adult zebra mussels could not survive (i.e., southern United States). The differences in mussel reproduction occurring from site-to-site make it difficult to predict timing of specific events, such as the start of larval production, that are important in initiating containment or control procedures. For example, the amount of time required for a fertilized egg to develop into a juvenile mussel can be as short as 8 days, or as long as 240 days. Release of gametes by adults can be a highly synchronized event, focused over a 1-2 week period, or it can be completely non-synchronized, occurring throughout the year. Zebra mussels in some localities start spawning at water temperatures of 12-13A?C, but do not start until water temperatures reaches 22A?C at other sites. While some of this variability in reproductive behavior stems from mussel adaptation to local conditions, part is due to difficulties in sampling these events. It is difficult to determine reproductive success of a specific population because of the problems in separating locally produced larvae from larvae drifting in from other areas. Further research is needed not only on the relationship between reproduction and environment at the community level, but also on the variability in response of individual mussels.

Comparison Evaluations of VRF and RTU Systems Performance on Flexible Research Platform

DOE PAGES

Lee, Je-hyeon; Im, Piljae; Munk, Jeffrey D.; ...

2018-04-05

The energy performance of a variable refrigerant flow (VRF) system was evaluated using an occupancy-emulated research building in the southeastern region of the United States. Full- and part-load performance of the VRF system in heating and cooling seasons was compared with a conventional rooftop unit (RTU) variable-air-volume system with electric resistance heating. During both the heating and cooling seasons, full- and part-load conditions (i.e., 100%, 75%, and 50% thermal loads) were maintained alternately for 2 to 3 days each, and the energy use, thermal conditions, and coefficient of performance (COP) for the RTU and VRF system were measured. During themore » cooling season, the VRF system had an average COP of 4.2, 3.9, and 3.7 compared with 3.1, 3.0, and 2.5 for the RTU system under 100%, 75%, and 50% load conditions and resulted in estimated energy savings of 30%, 37%, and 47%, respectively. Finally, during the heating season, the VRF system had an average COP ranging from 1.2 to 2.0, substantially higher than the COPs of the RTU system, and resulted in estimated energy savings of 51%, 47%, and 27% under the three load conditions, respectively.« less

Comparison Evaluations of VRF and RTU Systems Performance on Flexible Research Platform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Je-hyeon; Im, Piljae; Munk, Jeffrey D.

The energy performance of a variable refrigerant flow (VRF) system was evaluated using an occupancy-emulated research building in the southeastern region of the United States. Full- and part-load performance of the VRF system in heating and cooling seasons was compared with a conventional rooftop unit (RTU) variable-air-volume system with electric resistance heating. During both the heating and cooling seasons, full- and part-load conditions (i.e., 100%, 75%, and 50% thermal loads) were maintained alternately for 2 to 3 days each, and the energy use, thermal conditions, and coefficient of performance (COP) for the RTU and VRF system were measured. During themore » cooling season, the VRF system had an average COP of 4.2, 3.9, and 3.7 compared with 3.1, 3.0, and 2.5 for the RTU system under 100%, 75%, and 50% load conditions and resulted in estimated energy savings of 30%, 37%, and 47%, respectively. Finally, during the heating season, the VRF system had an average COP ranging from 1.2 to 2.0, substantially higher than the COPs of the RTU system, and resulted in estimated energy savings of 51%, 47%, and 27% under the three load conditions, respectively.« less

Prolonged cardiac effects of momentary assessed stressful events and worry episodes.

PubMed

Pieper, Suzanne; Brosschot, Jos F; van der Leeden, Rien; Thayer, Julian F

2010-07-01

To test the hypothesize that increased heart rate (HR) and decreased heart rate variability (HRV) are not only due to concurrent stressful events and worries but also to stressors and worries occurring in the preceding hours or stressors anticipated to occur in the next hour. Worry was expected to mediate at least part of the prolonged effects of stressors. Ambulatory HR and HRV of 73 teachers were recorded for 4 days, during which the participants reported occurrence and duration of worry episodes and stressful events on an hourly basis, using computerized diaries. Multilevel regression models were used, accounting for effects of several biobehavioral variables. Stressful events were not associated with changes in HR or HRV. However, worry episodes had effects on concurrent HR and HRV (2.55 beats/minute; -5.76 milliseconds) and HR and HRV in the succeeding hour (3.05 beats/minute; -5.80 milliseconds) and 2 hours later (1.52 beats/minute; -3.14 milliseconds). These findings were independent of emotions, physical activity, posture, and other biobehavioral factors. Worry has effects on cardiac activity, and these effects were still visible after 2 hours. The latter finding suggests that a considerable part of prolonged activation may be induced by unconscious stress-related cognition.

Trends and Variability of Global Fire Emissions Due To Historical Anthropogenic Activities

NASA Astrophysics Data System (ADS)

Ward, Daniel S.; Shevliakova, Elena; Malyshev, Sergey; Rabin, Sam

2018-01-01

Globally, fires are a major source of carbon from the terrestrial biosphere to the atmosphere, occurring on a seasonal cycle and with substantial interannual variability. To understand past trends and variability in sources and sinks of terrestrial carbon, we need quantitative estimates of global fire distributions. Here we introduce an updated version of the Fire Including Natural and Agricultural Lands model, version 2 (FINAL.2), modified to include multiday burning and enhanced fire spread rate in forest crowns. We demonstrate that the improved model reproduces the interannual variability and spatial distribution of fire emissions reported in present-day remotely sensed inventories. We use FINAL.2 to simulate historical (post-1700) fires and attribute past fire trends and variability to individual drivers: land use and land cover change, population growth, and lightning variability. Global fire emissions of carbon increase by about 10% between 1700 and 1900, reaching a maximum of 3.4 Pg C yr-1 in the 1910s, followed by a decrease to about 5% below year 1700 levels by 2010. The decrease in emissions from the 1910s to the present day is driven mainly by land use change, with a smaller contribution from increased fire suppression due to increased human population and is largest in Sub-Saharan Africa and South Asia. Interannual variability of global fire emissions is similar in the present day as in the early historical period, but present-day wildfires would be more variable in the absence of land use change.

Shelf-life extension of refrigerated Mediterranean mullet (Mullus surmuletus) using modified atmosphere packaging.

PubMed

Pournis, Nikolaos; Papavergou, Aikaterini; Badeka, Anastasia; Kontominas, Michael G; Savvaidis, Ioannis N

2005-10-01

The present work evaluated the quality and freshness characteristics and the effect of modified atmosphere packaging (MAP) on the shelf-life extension of refrigerated Mediterranean mullet using microbiological, biochemical, and sensory analyses. Fresh open sea red mullet (Mullus surmuletus) were packaged in four different atmospheres: M1, 10%/20%/70% (O2/ CO2/N2); M2, 10%/40%/50% (O2/CO2/N2); M3, 10%/60%/30% (O2/CO2/N2); identical fish samples were packaged in air. All fish were kept under refrigeration (4 +/- 0.5 degrees C) for 14 days. Of the three gas atmospheres, the 10%/40%/50% (M2) and 10%/ 60%/30% (M3) gas mixtures were the most effective for inhibiting growth of aerobic microflora in mullet samples until day 10 of refrigerated storage. H2S-producing bacteria and pseudomonads were part of the mullet microflora and their growth was partly inhibited under MAP conditions. Between these two bacterial groups, H2S-producing bacteria (including Shewanella putrefaciens) were dominant toward the end of the storage period, regardless of the packaging conditions. Brochothrix thermosphacta and lactic acid bacteria were found to be members of the final microbial flora of MAP and air-packaged mullet, whereas the Enterobacteriaceae population was lower than other bacterial groups. Of the chemical freshness indices determined, thiobarbituric acid values were variable in mullet samples irrespective of packaging conditions indicative of no specific oxidative rancidity trend. Based on sensorial data and aerobic plate count, trimethylamine nitrogen and total volatile basic nitrogen limit values in the range of ca. 15 to 23 and 52 to 60 mg N/100 g of fish muscle were obtained, respectively, for mullet packaged under modified atmosphere and air. Sensory analyses (odor and taste attributes) showed that the limit of sensorial acceptability was reached after ca. 6 days for the samples packaged in air, 8 days for the M1 and M3 samples, and after 10 days for the M2 samples. Respective shelf-life extension for fresh whole mullet was ca. 2 days (M1 and M3 gas mixtures), and 4 days (M2 gas mixture).

Daily variability in working memory is coupled with negative affect: the role of attention and motivation.

PubMed

Brose, Annette; Schmiedek, Florian; Lövdén, Martin; Lindenberger, Ulman

2012-06-01

Across days, individuals experience varying levels of negative affect, control of attention, and motivation. We investigated whether this intraindividual variability was coupled with daily fluctuations in working memory (WM) performance. In 100 days, 101 younger individuals worked on a spatial N-back task and rated negative affect, control of attention, and motivation. Results showed that individuals differed in how reliably WM performance fluctuated across days, and that subjective experiences were primarily linked to performance accuracy. WM performance was lower on days with higher levels of negative affect, reduced control of attention, and reduced task-related motivation. Thus, variables that were found to predict WM in between-subjects designs showed important relationships to WM at the within-person level. In addition, there was shared predictive variance among predictors of WM. Days with increased negative affect and reduced performance were also days with reduced control of attention and reduced motivation to work on tasks. These findings are in line with proposed mechanisms linking negative affect and cognitive performance.

A comparison of two methods to assess the usage of mobile hand-held communication devices.

PubMed

Berolo, Sophia; Steenstra, Ivan; Amick, Benjamin C; Wells, Richard P

2015-01-01

The purposes of this study were to: 1) examine agreement between self-reported measures of mobile device use and direct measures of use, and 2) understand how respondents thought about their device use when they provided self-reports. Self-reports of six categories of device use were obtained using a previously developed questionnaire, and direct measures of use were collected using a custom logging application (n = 47). Bland-Altman analyses were used to examine agreement between the two measurement approaches. Interviews targeted participants' experiences completing the device use section of the questionnaire. Self-reports of use on a typical day last week overestimated logged use. Overestimates tended to be low at low average usage times, and became more variable as usage time increased. Self-reports of use yesterday also exceeded logged use, however the degree of overestimation was less than for a typical day last week. Six themes were identified from interviews, including the thought process used by participants to arrive at usage and the ease of reporting usage. It is challenging for respondents of this questionnaire to provide accurate self-reports of use. The source of this challenge may be attributed to the intrinsic difficulty of estimating use, partly due to the multiple functions of the devices as well as the variability of use both within a day and a week. Research investigating the relationship between device use and health outcomes should include a logging application to examine exposure simultaneously with self-reports to better understand the sources of hazardous exposures.

Subjective but Not Actigraphy-Defined Sleep Predicts Next-Day Fatigue in Chronic Fatigue Syndrome: A Prospective Daily Diary Study.

PubMed

Russell, Charlotte; Wearden, Alison J; Fairclough, Gillian; Emsley, Richard A; Kyle, Simon D

2016-04-01

This study aimed to (1) examine the relationship between subjective and actigraphy-defined sleep, and next-day fatigue in chronic fatigue syndrome (CFS); and (2) investigate the potential mediating role of negative mood on this relationship. We also sought to examine the effect of presleep arousal on perceptions of sleep. Twenty-seven adults meeting the Oxford criteria for CFS and self-identifying as experiencing sleep difficulties were recruited to take part in a prospective daily diary study, enabling symptom capture in real time over a 6-day period. A paper diary was used to record nightly subjective sleep and presleep arousal. Mood and fatigue symptoms were rated four times each day. Actigraphy was employed to provide objective estimations of sleep duration and continuity. Multilevel modelling revealed that subjective sleep variables, namely sleep quality, efficiency, and perceiving sleep to be unrefreshing, predicted following-day fatigue levels, with poorer subjective sleep related to increased fatigue. Lower subjective sleep efficiency and perceiving sleep as unrefreshing predicted reduced variance in fatigue across the following day. Negative mood on waking partially mediated these relationships. Increased presleep cognitive and somatic arousal predicted self-reported poor sleep. Actigraphy-defined sleep, however, was not found to predict following-day fatigue. For the first time we show that nightly subjective sleep predicts next-day fatigue in CFS and identify important factors driving this relationship. Our data suggest that sleep specific interventions, targeting presleep arousal, perceptions of sleep and negative mood on waking, may improve fatigue in CFS. © 2016 Associated Professional Sleep Societies, LLC.

A Sensory Material Approach for Reducing Variability in Additively Manufactured Metal Parts.

PubMed

Franco, B E; Ma, J; Loveall, B; Tapia, G A; Karayagiz, K; Liu, J; Elwany, A; Arroyave, R; Karaman, I

2017-06-15

Despite the recent growth in interest for metal additive manufacturing (AM) in the biomedical and aerospace industries, variability in the performance, composition, and microstructure of AM parts remains a major impediment to its widespread adoption. The underlying physical mechanisms, which cause variability, as well as the scale and nature of variability are not well understood, and current methods are ineffective at capturing these details. Here, a Nickel-Titanium alloy is used as a sensory material in order to quantitatively, and rather rapidly, observe compositional and/or microstructural variability in selective laser melting manufactured parts; thereby providing a means to evaluate the role of process parameters on the variability. We perform detailed microstructural investigations using transmission electron microscopy at various locations to reveal the origins of microstructural variability in this sensory material. This approach helped reveal how reducing the distance between adjacent laser scans below a critical value greatly reduces both the in-sample and sample-to-sample variability. Microstructural investigations revealed that when the laser scan distance is wide, there is an inhomogeneity in subgrain size, precipitate distribution, and dislocation density in the microstructure, responsible for the observed variability. These results provide an important first step towards understanding the nature of variability in additively manufactured parts.

Statistical Techniques for Analyzing Process or "Similarity" Data in TID Hardness Assurance

NASA Technical Reports Server (NTRS)

Ladbury, R.

2010-01-01

We investigate techniques for estimating the contributions to TID hardness variability for families of linear bipolar technologies, determining how part-to-part and lot-to-lot variability change for different part types in the process.

Relating Regional Arctic Sea Ice and climate extremes over Europe

NASA Astrophysics Data System (ADS)

Ionita-Scholz, Monica; Grosfeld, Klaus; Lohmann, Gerrit; Scholz, Patrick

2016-04-01

The potential increase of temperature extremes under climate change is a major threat to society, as temperature extremes have a deep impact on environment, hydrology, agriculture, society and economy. Hence, the analysis of the mechanisms underlying their occurrence, including their relationships with the large-scale atmospheric circulation and sea ice concentration, is of major importance. At the same time, the decline in Arctic sea ice cover during the last 30 years has been widely documented and it is clear that this change is having profound impacts at regional as well as planetary scale. As such, this study aims to investigate the relation between the autumn regional sea ice concentration variability and cold winters in Europe, as identified by the numbers of cold nights (TN10p), cold days (TX10p), ice days (ID) and consecutive frost days (CFD). We analyze the relationship between Arctic sea ice variation in autumn (September-October-November) averaged over eight different Arctic regions (Barents/Kara Seas, Beaufort Sea, Chukchi/Bering Seas, Central Arctic, Greenland Sea, Labrador Sea/Baffin Bay, Laptev/East Siberian Seas and Northern Hemisphere) and variations in atmospheric circulation and climate extreme indices in the following winter season over Europe using composite map analysis. Based on the composite map analysis it is shown that the response of the winter extreme temperatures over Europe is highly correlated/connected to changes in Arctic sea ice variability. However, this signal is not symmetrical for the case of high and low sea ice years. Moreover, the response of temperatures extreme over Europe to sea ice variability over the different Arctic regions differs substantially. The regions which have the strongest impact on the extreme winter temperature over Europe are: Barents/Kara Seas, Beaufort Sea, Central Arctic and the Northern Hemisphere. For the years of high sea ice concentration in the Barents/Kara Seas there is a reduction in the number of cold nights, cold days, ice days and consecutive frost days over the western part of Europe. In the opposite case of low sea ice concentration over the Barents/Kara Seas an increase of up to 8 days/winter of cold nights and days is observed over the whole Europe and an increase of up to 4 days/winter in the number of ID and CFD is observed over the same regions. The cold winters over Europe (low sea ice years) are associated with anomalous anticyclone and the downstream development of a mid-latitude trough, which in turn favours the advection of cold air from the north, providing favourable conditions for severe winters over Europe. We suggest that these results can help to improve the seasonal predictions of winter extreme events over Europe. Due to the non-linear response to high vs. low sea ice years, the skill of the predictions might depend on the sign and amplitude of the anomalies.

Response of noctilucent cloud brightness to daily solar variations

NASA Astrophysics Data System (ADS)

Dalin, P.; Pertsev, N.; Perminov, V.; Dubietis, A.; Zadorozhny, A.; Zalcik, M.; McEachran, I.; McEwan, T.; Černis, K.; Grønne, J.; Taustrup, T.; Hansen, O.; Andersen, H.; Melnikov, D.; Manevich, A.; Romejko, V.; Lifatova, D.

2018-04-01

For the first time, long-term data sets of ground-based observations of noctilucent clouds (NLC) around the globe have been analyzed in order to investigate a response of NLC to solar UV irradiance variability on a day-to-day scale. NLC brightness has been considered versus variations of solar Lyman-alpha flux. We have found that day-to-day solar variability, whose effect is generally masked in the natural NLC variability, has a statistically significant effect when considering large statistics for more than ten years. Average increase in day-to-day solar Lyman-α flux results in average decrease in day-to-day NLC brightness that can be explained by robust physical mechanisms taking place in the summer mesosphere. Average time lags between variations of Lyman-α flux and NLC brightness are short (0-3 days), suggesting a dominant role of direct solar heating and of the dynamical mechanism compared to photodissociation of water vapor by solar Lyman-α flux. All found regularities are consistent between various ground-based NLC data sets collected at different locations around the globe and for various time intervals. Signatures of a 27-day periodicity seem to be present in the NLC brightness for individual summertime intervals; however, this oscillation cannot be unambiguously retrieved due to inevitable periods of tropospheric cloudiness.

THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: RAPID C iv BROAD ABSORPTION LINE VARIABILITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grier, C. J.; Brandt, W. N.; Trump, J. R.

2015-06-10

We report the discovery of rapid variations of a high-velocity C iv broad absorption line trough in the quasar SDSS J141007.74+541203.3. This object was intensively observed in 2014 as a part of the Sloan Digital Sky Survey Reverberation Mapping Project, during which 32 epochs of spectroscopy were obtained with the Baryon Oscillation Spectroscopic Survey spectrograph. We observe significant (>4σ) variability in the equivalent width (EW) of the broad (∼4000 km s{sup −1} wide) C iv trough on rest-frame timescales as short as 1.20 days (∼29 hr), the shortest broad absorption line variability timescale yet reported. The EW varied by ∼10%more » on these short timescales, and by about a factor of two over the duration of the campaign. We evaluate several potential causes of the variability, concluding that the most likely cause is a rapid response to changes in the incident ionizing continuum. If the outflow is at a radius where the recombination rate is higher than the ionization rate, the timescale of variability places a lower limit on the density of the absorbing gas of n{sub e} ≳ 3.9 × 10{sup 5} cm{sup −3}. The broad absorption line variability characteristics of this quasar are consistent with those observed in previous studies of quasars, indicating that such short-term variability may in fact be common and thus can be used to learn about outflow characteristics and contributions to quasar/host-galaxy feedback scenarios.« less

The influence of betamethasone on fetal heart rate variability, obtained by non-invasive fetal electrocardiogram recordings.

PubMed

Verdurmen, Kim M J; Warmerdam, Guy J J; Lempersz, Carlijn; Hulsenboom, Alexandra D J; Renckens, Joris; Dieleman, Jeanne P; Vullings, Rik; van Laar, Judith O E H; Oei, S Guid

2018-04-01

Betamethasone is widely used to enhance fetal lung maturation in case of threatened preterm labour. Fetal heart rate variability is one of the most important parameters to assess in fetal monitoring, since it is a reliable indicator for fetal distress. To describe the effect of betamethasone on fetal heart rate variability, by applying spectral analysis on non-invasive fetal electrocardiogram recordings. Prospective cohort study. Patients that require betamethasone, with a gestational age from 24 weeks onwards. Fetal heart rate variability parameters on day 1, 2, and 3 after betamethasone administration are compared to a reference measurement. Following 68 inclusions, 12 patients remained with complete series of measurements and sufficient data quality. During day 1, an increase in absolute fetal heart rate variability values was seen. During day 2, a decrease in these values was seen. All trends indicate to return to pre-medication values on day 3. Normalised high- and low-frequency power show little changes during the study period. The changes in fetal heart rate variability following betamethasone administration show the same pattern when calculated by spectral analysis of the fetal electrocardiogram, as when calculated by cardiotocography. Since normalised spectral values show little changes, the influence of autonomic modulation seems minor. Copyright © 2018 Elsevier B.V. All rights reserved.

Variability and predictors of negative mood intensity in patients with borderline personality disorder and recurrent suicidal behavior: multilevel analyses applied to experience sampling methodology.

PubMed

Nisenbaum, Rosane; Links, Paul S; Eynan, Rahel; Heisel, Marnin J

2010-05-01

Variability in mood swings is a characteristic of borderline personality disorder (BPD) and is associated with suicidal behavior. This study investigated patterns of mood variability and whether such patterns could be predicted from demographic and suicide-related psychological risk factors. Eighty-two adults with BPD and histories of recurrent suicidal behavior were recruited from 3 outpatient psychiatric programs in Canada. Experience sampling methodology (ESM) was used to assess negative mood intensity ratings on a visual analogue scale, 6 random times daily, for 21 days. Three-level models estimated variability between times (52.8%), days (22.2%), and patients (25.1%) and supported a quadratic pattern of daily mood variability. Depression scores predicted variability between patients' initial rating of the day. Average daily mood patterns depended on levels of hopelessness, suicide ideation, and sexual abuse history. Patients reporting moderate to severe sexual abuse and elevated suicide ideation were characterized by worsening moods from early morning up through evening, with little or no relief; patients reporting mild sexual abuse and low suicide ideation reported improved mood throughout the day. These patterns, if replicated in larger ESM studies, may potentially assist the clinician in determining which patients require close monitoring.

Periodic and Aperiodic Variability in the Molecular Cloud ρ Ophiuchus

NASA Astrophysics Data System (ADS)

Parks, J. Robert; Plavchan, Peter; White, Russel J.; Gee, Alan H.

2014-03-01

Presented are the results of a near-IR photometric survey of 1678 stars in the direction of the ρ Ophiuchus (ρ Oph) star forming region using data from the 2MASS Calibration Database. For each target in this sample, up to 1584 individual J-, H-, and Ks -band photometric measurements with a cadence of ~1 day are obtained over three observing seasons spanning ~2.5 yr it is the most intensive survey of stars in this region to date. This survey identifies 101 variable stars with ΔKs -band amplitudes from 0.044 to 2.31 mag and Δ(J - Ks ) color amplitudes ranging from 0.053 to 1.47 mag. Of the 72 young ρ Oph star cluster members included in this survey, 79% are variable; in addition, 22 variable stars are identified as candidate members. Based on the temporal behavior of the Ks time-series, the variability is distinguished as either periodic, long time-scale or irregular. This temporal behavior coupled with the behavior of stellar colors is used to assign a dominant variability mechanism. A new period-searching algorithm finds periodic signals in 32 variable stars with periods between 0.49 to 92 days. The chief mechanism driving the periodic variability for 18 stars is rotational modulation of cool starspots while 3 periodically vary due to accretion-induced hot spots. The time-series for six variable stars contains discrete periodic "eclipse-like" features with periods ranging from 3 to 8 days. These features may be asymmetries in the circumstellar disk, potentially sustained or driven by a proto-planet at or near the co-rotation radius. Aperiodic, long time-scale variations in stellar flux are identified in the time-series for 31 variable stars with time-scales ranging from 64 to 790 days. The chief mechanism driving long time-scale variability is variable extinction or mass accretion rates. The majority of the variable stars (40) exhibit sporadic, aperiodic variability over no discernable time-scale. No chief variability mechanism could be identified for these variable stars.

Variability of Travel Times on New Jersey Highways

DOT National Transportation Integrated Search

2011-06-01

This report presents the results of a link and path travel time study conducted on selected New Jersey (NJ) highways to produce estimates of the corresponding variability of travel time (VTT) by departure time of the day and days of the week. The tra...

Delineation of Spatial Variability in the Temperature-Mortality Relationship on Extremely Hot Days in Greater Vancouver, Canada.

PubMed

Ho, Hung Chak; Knudby, Anders; Walker, Blake Byron; Henderson, Sarah B

2017-01-01

Climate change has increased the frequency and intensity of extremely hot weather. The health risks associated with extemely hot weather are not uniform across affected areas owing to variability in heat exposure and social vulnerability, but these differences are challenging to map with precision. We developed a spatially and temporally stratified case-crossover approach for delineation of areas with higher and lower risks of mortality on extremely hot days and applied this approach in greater Vancouver, Canada. Records of all deaths with an extremely hot day as a case day or a control day were extracted from an administrative vital statistics database spanning the years of 1998-2014. Three heat exposure and 11 social vulnerability variables were assigned at the residential location of each decedent. Conditional logistic regression was used to estimate the odds ratio for a 1°C increase in daily mean temperature at a fixed site with an interaction term for decedents living above and below different values of the spatial variables. The heat exposure and social vulnerability variables with the strongest spatially stratified results were the apparent temperature and the labor nonparticipation rate, respectively. Areas at higher risk had values ≥ 34.4°C for the maximum apparent temperature and ≥ 60% of the population neither employed nor looking for work. These variables were combined in a composite index to quantify their interaction and to enhance visualization of high-risk areas. Our methods provide a data-driven framework for spatial delineation of the temperature--mortality relationship by heat exposure and social vulnerability. The results can be used to map and target the most vulnerable areas for public health intervention. Citation: Ho HC, Knudby A, Walker BB, Henderson SB. 2017. Delineation of spatial variability in the temperature-mortality relationship on extremely hot days in greater Vancouver, Canada. Environ Health Perspect 125:66-75; http://dx.doi.org/10.1289/EHP224.

Delineation of Spatial Variability in the Temperature–Mortality Relationship on Extremely Hot Days in Greater Vancouver, Canada

PubMed Central

Ho, Hung Chak; Knudby, Anders; Walker, Blake Byron; Henderson, Sarah B.

2016-01-01

Background: Climate change has increased the frequency and intensity of extremely hot weather. The health risks associated with extemely hot weather are not uniform across affected areas owing to variability in heat exposure and social vulnerability, but these differences are challenging to map with precision. Objectives: We developed a spatially and temporally stratified case-crossover approach for delineation of areas with higher and lower risks of mortality on extremely hot days and applied this approach in greater Vancouver, Canada. Methods: Records of all deaths with an extremely hot day as a case day or a control day were extracted from an administrative vital statistics database spanning the years of 1998–2014. Three heat exposure and 11 social vulnerability variables were assigned at the residential location of each decedent. Conditional logistic regression was used to estimate the odds ratio for a 1°C increase in daily mean temperature at a fixed site with an interaction term for decedents living above and below different values of the spatial variables. Results: The heat exposure and social vulnerability variables with the strongest spatially stratified results were the apparent temperature and the labor nonparticipation rate, respectively. Areas at higher risk had values ≥ 34.4°C for the maximum apparent temperature and ≥ 60% of the population neither employed nor looking for work. These variables were combined in a composite index to quantify their interaction and to enhance visualization of high-risk areas. Conclusions: Our methods provide a data-driven framework for spatial delineation of the temperature-–mortality relationship by heat exposure and social vulnerability. The results can be used to map and target the most vulnerable areas for public health intervention. Citation: Ho HC, Knudby A, Walker BB, Henderson SB. 2017. Delineation of spatial variability in the temperature–mortality relationship on extremely hot days in greater Vancouver, Canada. Environ Health Perspect 125:66–75; http://dx.doi.org/10.1289/EHP224 PMID:27346526

Determination of annual and seasonal daytime and nighttime trends of MODIS LST over Greece - climate change implications.

PubMed

Eleftheriou, Dimitrios; Kiachidis, Kyriakos; Kalmintzis, Georgios; Kalea, Argiro; Bantasis, Christos; Koumadoraki, Paraskevi; Spathara, Maria Eleni; Tsolaki, Angeliki; Tzampazidou, Maria Irini; Gemitzi, Alexandra

2018-03-01

Climate change is one of the most challenging research topics during the last few decades, as temperature rise has already posed a significant impact on the earth's functions thus affecting all life of the planet. Land Surface Temperature (LST) is identified as a key variable in environmental and climate studies. The present study investigates the distribution of daytime and nighttime LST trends over Greece, a country in the Mediterranean area which is identified as one of the main "hot-spots" of climate change projections. Remotely sensed LST data were obtained from MODerate Resolution Imaging Spectroradiometer (MODIS) sensor in the form of 8-day composites of day and night values at a resolution of 1km for a 17-year period, i.e. from 2000 to 2017. Spatial aggregates of 10km×10km were computed and the annual and seasonal temporal trends were determined for each one of those sub-areas. Results showed that annual trends of daily LST in the majority of areas demonstrated decrease ranging from -1∗10 -2 °C to -1.3∗10 -3 °C, with some sporadic parts showing a slight increase. A totally different outcome is observed in the fate of night LST, with all areas over Greece demonstrating increasing annual trends ranging from 4.6∗10 -5 °C to 3.1∗10 -3 °C, with highest values in the South-East parts of the country. Seasonal trends in day and night LST showed the same pattern, i.e., a general decrease in the day LST and a definite increase in night. An interesting finding is the increase in winter LST trends observed both for day and night LST, indicating that the absolute minimum annual LST observed during winter in Greece increases. Our results also indicate that the annual diurnal LST range is decreasing. Copyright © 2017 Elsevier B.V. All rights reserved.

Social and Economic Characteristics of Street Youth by Gender and Level of Street Involvement in Eldoret, Kenya

PubMed Central

Sorber, Rebecca; Winston, Susanna; Koech, Julius; Ayuku, David; Hu, Liangyuan; Hogan, Joseph; Braitstein, Paula

2014-01-01

Background Street-connected youth are a neglected and vulnerable population, particularly in resource-constrained settings. The development of interventions and supports for this population requires insight into how they live. This study describes the social and economic characteristics of a convenience sample of street youth (SY) in Eldoret, Kenya. Methods Participants were eligible if they were aged 12–21, living in Eldoret, spending days only (part-time), or nights and days on the street (full-time) and able and willing to consent or assent. Data were collected using a standardized interview conducted in English or Kiswahili. Binary dependent variables were having been arrested and/or jailed, and first priority for spending money (food vs. other). Nominal categorical dependent variables included major source of support, and major reason for being street-involved. Multivariable analysis used logistic regression models to examine the association of gender and level of street-involvement with social and economic factors of interest adjusting for age and length of time on the street. Data were analyzed using SAS 9.3. Results Of the 200 SY enrolled, 41% were female, mean age of 16.3 years; 71% were on the street full-time, and 29% part-time. Compared with part-time SY, full-time SY were more likely to have been arrested (Adjusted Odds Ratio [AOR]: 2.33, 95% Confidence Interval [95%CI]:1.01–5.35), name food as their first spending priority (AOR: 2.57, 95%CI:1.03–6.45), have left home due to violence (AOR: 5.54, 95%CI: 1.67–18.34), and more likely to report friends on the street as a major source of support (AOR: 3.59, 95% CI: 1.01–12.82). Compared with females, males were more likely to have ever been arrested (AOR: 2.66, 95%CI:1.14–6.18), and to have ever been jailed (AOR: 3.22, 95%CI:1.47–7.02). Conclusions These results suggest a high degree of heterogeneity and vulnerability among SY in this setting. There is an urgent need for interventions taking into consideration these characteristics. PMID:24827584

Home brewery as science investigation

NASA Astrophysics Data System (ADS)

Flander, Renata

2017-04-01

Part of the compulsory program in primary school is to promote the cross-curricular links among different subjects, days of science in particular make this possible. We organize these days like science investigations for 9th graders. They do some research on the first day and present the results on the second day. Because some experiments with living beings last for a long time, we have at least a two week long break. In the meantime children are encouraged to work on their project, they search for better solutions, do some extra measurement, etc. Students are also stimulated to upgrade their knowledge, be innovative, to come up with individual contributions in the presentations and actively participate in the debate at the plenary presentation at the end of the second day. We offer different workshops to children (catalysts, smart cars, electronics in the hen house, plants in the universe, solar panel and home brewery) but we follow the same objectives like being able to plan a simple scientific investigation (form the question, hypothesis, variables, etc.), being able to use tools and technology for experimenting, collecting and presenting data with critical evaluation, being able to share and present new information. Pupils that choose home brewery are invited to come up with a statement like "Brewer agency has prepared a contract to investigate the influence of different ingredients in beer production with a purpose of preparing beer with the highest amount of alcohol." They start investigating at home by looking into how beer is made and according to the statement they also form questions, hypotheses, variables and make a plan. At school they form groups, present their plans and discuss best options to make a beer. They join their forces and each group prepares beer in the same way, changing only one variable (for example: added sugar, type of cereal). During making beer students also acquire other skills through the following activities: - Measuring sugar with Benedict solution and starch with iodine solution in malt before and after soaking. - Detecting carbo - dioxide with the use of indicators (bromothymol blue, litmus) or with the limewater test. - Preparing a microscope slide and use the microscope to observe the yeast. - Making a scientific drawing. - Taking pictures about their work to gather the right material for the final report. On the second day they measure the alcohol content and verify their hypotheses. They write a report using the scientific ideas, think how to improve the experiment and how to apply it in every-day life. However, it is important to mention that alcohol can be dangerous. The results are presented at the plenary presentation, students make posters or computer presentations by using their own devices.

[Tolerance, safety and efficacy of the one-day preparation of PEG3350 + bisacodyl compared to 2 days of PEG3350 + bisacodyl in pediatric patients].

PubMed

Portillo Canizalez, Ligia Marcela; Blanco Rodriguez, Gerardo; Teyssier Morales, Gustavo; Penchyna Grub, Jaime; Trauernicht Mendieta, Sean; Zurita-Cruz, Jessie Nallely

Multiple intestinal preparations have been used in children undergoing colonoscopy, with variable limitation due to acceptance, tolerance, and proper cleaning. The objective of this study was to compare the tolerability, safety and efficacy of the colonoscopy preparation with 1 day with PEG 3350 (poliethylenglycol) (4g/kg/day) + bisacodyl compared to 2 days of preparation with PEG 3350 (2g/kg/day) + bisacodyl in pediatric patients. A clinical, randomized, and blind trial was performed. Patients aged 2 to 18 years scheduled for colonoscopy were included. Patients were randomized into two groups: 1 day of preparation with PEG 3350 4g/kg/day + bisacodyl and 2 days of preparation with PEG 3350 2g/kg/day + bisacodyl. Through a questionnaire, physical examination and endoscopic evaluation (Boston scale), the tolerance, safety and efficacy of the 2 preparations to be evaluated were determined. Student's t test was performed for quantitative variables and χ 2 for qualitative variables. There were no significant differences in compliance rates, adverse effects, and extent of colonoscopic evaluation. Tolerance and safety between the intestinal preparation for 1-day colonoscopy with PEG 3350 (4g/kg/day) + bisacodyl and the 2-day preparation with PEG 3350 (2g/kg/day) + bisacodyl were similar. The quality of cleanliness was good in both groups, being partially more effective in the 1-day group with PEG 3350 (4g/kg/day). Copyright © 2017 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

CAN'T MISS--conquer any number task by making important statistics simple. Part 1. Types of variables, mean, median, variance, and standard deviation.

PubMed

Hansen, John P

2003-01-01

Healthcare quality improvement professionals need to understand and use inferential statistics to interpret sample data from their organizations. In quality improvement and healthcare research studies all the data from a population often are not available, so investigators take samples and make inferences about the population by using inferential statistics. This three-part series will give readers an understanding of the concepts of inferential statistics as well as the specific tools for calculating confidence intervals for samples of data. This article, Part 1, presents basic information about data including a classification system that describes the four major types of variables: continuous quantitative variable, discrete quantitative variable, ordinal categorical variable (including the binomial variable), and nominal categorical variable. A histogram is a graph that displays the frequency distribution for a continuous variable. The article also demonstrates how to calculate the mean, median, standard deviation, and variance for a continuous variable.

29 CFR 1614.604 - Filing and computation of time.

Code of Federal Regulations, 2010 CFR

2010-07-01

... within five days of the expiration of the applicable filing period. (c) The time limits in this part are subject to waiver, estoppel and equitable tolling. (d) The first day counted shall be the day after the.... (a) All time periods in this part that are stated in terms of days are calendar days unless otherwise...

12 CFR 268.604 - Filing and computation of time.

Code of Federal Regulations, 2010 CFR

2010-01-01

... mail within five days of the expiration of the applicable filing period. (c) The time limits in this part are subject to waiver, estoppel and equitable tolling. (d) The first day counted shall be the day... computation of time. (a) All time periods in this part that are stated in terms of days are calendar days...

Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project.

PubMed

Martin-Trias, Pablo; Lanteaume, Laura; Solana, Elisabeth; Cassé-Perrot, Catherine; Fernández-Cabello, Sara; Babiloni, Claudio; Marzano, Nicola; Junqué, Carme; Rossini, Paolo Maria; Micallef, Joëlle; Truillet, Romain; Charles, Estelle; Jouve, Elisabeth; Bordet, Régis; Santamaria, Joan; Jovicich, Jorge; Rossi, Simone; Pascual-Leone, Alvaro; Blin, Olivier; Richardson, Jill; Bartrés-Faz, David

2018-06-19

Transcranial magnetic stimulation (TMS) can interfere with cognitive processes, such as transiently impairing memory. As part of a multi-center European project, we investigated the adaptability and reproducibility of a previously published TMS memory interfering protocol in two centers using EEG or fMRI scenarios. Participants were invited to attend three experimental sessions on different days, with sham repetitive TMS (rTMS) applied on day 1 and real rTMS on days 2 and 3. Sixty-eight healthy young men were included. On each experimental day, volunteers were instructed to remember visual pictures while receiving neuronavigated rTMS trains (20 Hz, 900 ms) during picture encoding at the left dorsolateral prefrontal cortex (L-DLPFC) and the vertex. Mixed ANOVA model analyses were performed. rTMS to the L-DLPFC significantly disrupted recognition memory on experimental day 2. No differences were found between centers or between fMRI and EEG recordings. Subjects with lower baseline memory performances were more susceptible to TMS disruption. No stability of TMS-induced memory interference could be demonstrated on day 3. Our data suggests that adapted cognitive rTMS protocols can be implemented in multi-center studies incorporating standardized experimental procedures. However, our center and modality effects analyses lacked sufficient statistical power, hence highlighting the need to conduct further studies with larger samples. In addition, inter and intra-subject variability in response to TMS might limit its application in crossover or longitudinal studies.

Better or Worse: a Study of Day-to-Day Changes over Five Months of Rosen Method Bodywork Treatment for Chronic Low Back Pain.

PubMed

Fogel, Alan

2013-01-01

Fluctuations of good days and bad days-in physical symptoms and emotional states-are common for individuals with chronic illness. This pilot study examines these fluctuations during bodywork treatment. We analyzed changes in daily self-reports over a period of five months for five individuals who received weekly treatments of Rosen Method Bodywork (RMB), which uses touch and words to enhance body awareness of physical sensations and emotional states. Five subjects (aged 31-56) who had chronic low back pain (CLBP) received 16 weekly treatments given by three experienced RMB practitioners. Pre- and posttreatment assessments covered demographics, disability, and pain. Clients also completed daily bedtime assessments of pain, fatigue, emotional state, and sense of control during the entire treatment period. All clients reported reductions in pain and/or disability in post- compared to pretreatment. In spite of a high level of day-to-day variability in the daily assessments, there were significant reductions in pain and fatigue, and significant increases in positive emotional state and sense of control across the treatment period. In reaching this end, however, some clients had slow and steady improvements, some improved more rapidly, while others got worse before they got better. The natural course of healing-with its inevitable fluctuations in symptoms-is part of a process leading to successful treatment outcomes. Rosen Method Bodywork may be especially helpful in developing and accepting both sensory and emotional body awareness changes that facilitate overall improvement.

19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII-A to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day Sunset...

19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 3 2014-04-01 2014-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII-A to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day Sunset...

19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 3 2012-04-01 2012-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII-A to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day Sunset...

19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 3 2013-04-01 2013-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII-A to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day Sunset...

19 CFR Annex Viii-A to Part 351 - Schedule for 90-Day Sunset Reviews

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 3 2011-04-01 2011-04-01 false Schedule for 90-Day Sunset Reviews VIII Annex VIII-A to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VIII-A Annex VIII-A to Part 351—Schedule for 90-Day Sunset...

Subjective but Not Actigraphy-Defined Sleep Predicts Next-Day Fatigue in Chronic Fatigue Syndrome: A Prospective Daily Diary Study

PubMed Central

Russell, Charlotte; Wearden, Alison J.; Fairclough, Gillian; Emsley, Richard A.; Kyle, Simon D.

2016-01-01

Study Objectives: This study aimed to (1) examine the relationship between subjective and actigraphy-defined sleep, and next-day fatigue in chronic fatigue syndrome (CFS); and (2) investigate the potential mediating role of negative mood on this relationship. We also sought to examine the effect of presleep arousal on perceptions of sleep. Methods: Twenty-seven adults meeting the Oxford criteria for CFS and self-identifying as experiencing sleep difficulties were recruited to take part in a prospective daily diary study, enabling symptom capture in real time over a 6-day period. A paper diary was used to record nightly subjective sleep and presleep arousal. Mood and fatigue symptoms were rated four times each day. Actigraphy was employed to provide objective estimations of sleep duration and continuity. Results: Multilevel modelling revealed that subjective sleep variables, namely sleep quality, efficiency, and perceiving sleep to be unrefreshing, predicted following-day fatigue levels, with poorer subjective sleep related to increased fatigue. Lower subjective sleep efficiency and perceiving sleep as unrefreshing predicted reduced variance in fatigue across the following day. Negative mood on waking partially mediated these relationships. Increased presleep cognitive and somatic arousal predicted self-reported poor sleep. Actigraphy-defined sleep, however, was not found to predict following-day fatigue. Conclusions: For the first time we show that nightly subjective sleep predicts next-day fatigue in CFS and identify important factors driving this relationship. Our data suggest that sleep specific interventions, targeting presleep arousal, perceptions of sleep and negative mood on waking, may improve fatigue in CFS. Citation: Russell C, Wearden AJ, Fairclough G, Emsley RA, Kyle SD. Subjective but not actigraphy-defined sleep predicts next-day fatigue in chronic fatigue syndrome: a prospective daily diary study. SLEEP 2016;39(4):937–944. PMID:26715232

Temporal Variability of Daily Personal Magnetic Field Exposure Metrics in Pregnant Women

PubMed Central

Lewis, Ryan C.; Evenson, Kelly R.; Savitz, David A.; Meeker, John D.

2015-01-01

Recent epidemiology studies of power-frequency magnetic fields and reproductive health have characterized exposures using data collected from personal exposure monitors over a single day, possibly resulting in exposure misclassification due to temporal variability in daily personal magnetic field exposure metrics, but relevant data in adults are limited. We assessed the temporal variability of daily central tendency (time-weighted average, median) and peak (upper percentiles, maximum) personal magnetic field exposure metrics over seven consecutive days in 100 pregnant women. When exposure was modeled as a continuous variable, central tendency metrics had substantial reliability, whereas peak metrics had fair (maximum) to moderate (upper percentiles) reliability. The predictive ability of a single day metric to accurately classify participants into exposure categories based on a weeklong metric depended on the selected exposure threshold, with sensitivity decreasing with increasing exposure threshold. Consistent with the continuous measures analysis, sensitivity was higher for central tendency metrics than for peak metrics. If there is interest in peak metrics, more than one day of measurement is needed over the window of disease susceptibility to minimize measurement error, but one day may be sufficient for central tendency metrics. PMID:24691007

Effects of microclimatic variables on the symptoms and signs onset of Moniliophthora roreri, causal agent of Moniliophthora pod rot in cacao

PubMed Central

Tixier, Philippe; Germon, Amandine; Rakotobe, Veromanitra; Phillips-Mora, Wilbert; Maximova, Siela; Avelino, Jacques

2017-01-01

Moniliophthora Pod Rot (MPR) caused by the fungus Moniliophthora roreri (Cif.) Evans et al., is one of the main limiting factors of cocoa production in Latin America. Currently insufficient information on the biology and epidemiology of the pathogen limits the development of efficient management options to control MPR. This research aims to elucidate MPR development through the following daily microclimatic variables: minimum and maximum temperatures, wetness frequency, average temperature and relative humidity in the highly susceptible cacao clone Pound-7 (incidence = 86% 2008–2013 average). A total of 55 cohorts totaling 2,268 pods of 3–10 cm length, one to two months of age, were tagged weekly. Pods were assessed throughout their lifetime, every one or two weeks, and classified in 3 different categories: healthy, diseased with no sporulation, diseased with sporulating lesions. As a first step, we used Generalized Linear Mixed Models (GLMM) to determine with no a priori the period (when and for how long) each climatic variable was better related with the appearance of symptoms and sporulation. Then the significance of the candidate variables was tested in a complete GLMM. Daily average wetness frequency from day 14 to day 1, before tagging, and daily average maximum temperature from day 4 to day 21, after tagging, were the most explanatory variables of the symptoms appearance. The former was positively linked with the symptoms appearance when the latter exhibited a maximum at 30°C. The most important variables influencing sporulation were daily average minimum temperature from day 35 to day 58 and daily average maximum temperature from day 37 to day 48, both after tagging. Minimum temperature was negatively linked with the sporulation while maximum temperature was positively linked. Results indicated that the fungal microclimatic requirements vary from the early to the late cycle stages, possibly due to the pathogen’s long latent period. This information is valuable for development of new conceptual models for MPR and improvement of control methods. PMID:28972981

Effects of microclimatic variables on the symptoms and signs onset of Moniliophthora roreri, causal agent of Moniliophthora pod rot in cacao.

PubMed

Leandro-Muñoz, Mariela E; Tixier, Philippe; Germon, Amandine; Rakotobe, Veromanitra; Phillips-Mora, Wilbert; Maximova, Siela; Avelino, Jacques

2017-01-01

Moniliophthora Pod Rot (MPR) caused by the fungus Moniliophthora roreri (Cif.) Evans et al., is one of the main limiting factors of cocoa production in Latin America. Currently insufficient information on the biology and epidemiology of the pathogen limits the development of efficient management options to control MPR. This research aims to elucidate MPR development through the following daily microclimatic variables: minimum and maximum temperatures, wetness frequency, average temperature and relative humidity in the highly susceptible cacao clone Pound-7 (incidence = 86% 2008-2013 average). A total of 55 cohorts totaling 2,268 pods of 3-10 cm length, one to two months of age, were tagged weekly. Pods were assessed throughout their lifetime, every one or two weeks, and classified in 3 different categories: healthy, diseased with no sporulation, diseased with sporulating lesions. As a first step, we used Generalized Linear Mixed Models (GLMM) to determine with no a priori the period (when and for how long) each climatic variable was better related with the appearance of symptoms and sporulation. Then the significance of the candidate variables was tested in a complete GLMM. Daily average wetness frequency from day 14 to day 1, before tagging, and daily average maximum temperature from day 4 to day 21, after tagging, were the most explanatory variables of the symptoms appearance. The former was positively linked with the symptoms appearance when the latter exhibited a maximum at 30°C. The most important variables influencing sporulation were daily average minimum temperature from day 35 to day 58 and daily average maximum temperature from day 37 to day 48, both after tagging. Minimum temperature was negatively linked with the sporulation while maximum temperature was positively linked. Results indicated that the fungal microclimatic requirements vary from the early to the late cycle stages, possibly due to the pathogen's long latent period. This information is valuable for development of new conceptual models for MPR and improvement of control methods.

Sleep and circadian variability in people with delayed sleep-wake phase disorder versus healthy controls.

PubMed

Burgess, Helen J; Park, Margaret; Wyatt, James K; Rizvydeen, Muneer; Fogg, Louis F

2017-06-01

To compare sleep and circadian variability in adults with delayed sleep-wake phase disorder (DSWPD) to healthy controls. Forty participants (22 DSWPD, 18 healthy controls) completed a ten-day protocol, consisting of DLMO assessments on two consecutive nights, a five-day study break, followed by two more DLMO assessments. All participants were instructed to sleep within one hour of their self-reported average sleep schedule for the last four days of the study break. We analyzed the participants' wrist actigraphy data during these four days to examine intraindividual variability in sleep timing, duration and efficiency. We also examined shifts in the DLMO from before and after the study break. Under the same conditions, people with DSWPD had significantly more variable wake times and total sleep time than healthy controls (p ≤ 0.015). Intraindividual variability in sleep onset time and sleep efficiency was similar between the two groups (p ≥ 0.30). The DLMO was relatively stable across the study break, with only 11% of controls but 27% of DSWPDs showed more than a one hour shift in the DLMO. Only in the DSWPD sample was greater sleep variability associated with a larger shift in the DLMO (r = 0.46, p = 0.03). These results suggest that intraindividual variability in sleep can be higher in DSWPD versus healthy controls, and this may impact variability in the DLMO. DSWPD patients with higher intraindividual variability in sleep are more likely to have a shifting DLMO, which could impact sleep symptoms and the optimal timing of light and/or melatonin treatment for DSWPD. Circadian Phase Assessments at Home, http://clinicaltrials.gov/show/NCT01487252, NCT01487252. Copyright © 2017 Elsevier B.V. All rights reserved.

Sleep and Circadian Variability in People with Delayed Sleep-Wake Phase Disorder versus Healthy Controls

PubMed Central

Burgess, Helen J.; Park, Margaret; Wyatt, James K.; Rizvydeen, Muneer; Fogg, Louis F.

2017-01-01

Objective/Background To compare sleep and circadian variability in adults with delayed sleep-wake phase disorder (DSWPD) to healthy controls. Patients/Methods Forty participants (22 DSWPD, 18 healthy controls) completed a 10-day protocol, consisting of DLMO assessments on two consecutive nights, a five-day study break, followed by two more DLMO assessments. All participants were instructed to sleep within one hour of their self-reported average sleep schedule for the last four days of the study break. We analyzed the participants’ wrist actigraphy data during these four days to examine intraindividual variability in sleep timing, duration and efficiency. We also examined shifts in the DLMO from before and after the study break. Results and Conclusions Under the same conditions, people with DSWPD had significantly more variable wake times and total sleep time than healthy controls (p≤0.015). Intraindividual variability in sleep onset time and sleep efficiency was similar between the two groups (p≥0.30). The DLMO was relatively stable across the study break, with only 11% of controls but 27% of DSWPDs showed more than a one hour shift in the DLMO. Only in the DSWPD sample was greater sleep variability associated with a larger shift in the DLMO (r=0.46, p=0.03). These results suggest that intraindividual variability in sleep can be higher in DSWPD versus healthy controls, and this may impact variability in the DLMO. DSWPD patients with higher intraindividual variability in sleep are more likely to have a shifting DLMO, which could impact sleep symptoms and the optimal timing of light and/or melatonin treatment for DSWPD. PMID:28522096

Spatio-temporal variability of soil water content on the local scale in a Mediterranean mountain area (Vallcebre, North Eastern Spain). How different spatio-temporal scales reflect mean soil water content

NASA Astrophysics Data System (ADS)

Molina, Antonio J.; Latron, Jérôme; Rubio, Carles M.; Gallart, Francesc; Llorens, Pilar

2014-08-01

As a result of complex human-land interactions and topographic variability, many Mediterranean mountain catchments are covered by agricultural terraces that have locally modified the soil water content dynamic. Understanding these local-scale dynamics helps us grasp better how hydrology behaves on the catchment scale. Thus, this study examined soil water content variability in the upper 30 cm of the soil on a Mediterranean abandoned terrace in north-east Spain. Using a dataset of high spatial (regular grid of 128 automatic TDR probes at 2.5 m intervals) and temporal (20-min time step) resolution, gathered throughout a 84-day period, the spatio-temporal variability of soil water content at the local scale and the way that different spatio-temporal scales reflect the mean soil water content were investigated. Soil water content spatial variability and its relation to wetness conditions were examined, along with the spatial structuring of the soil water content within the terrace. Then, the ability of single probes and of different combinations of spatial measurements (transects and grids) to provide a good estimate of mean soil water content on the terrace scale was explored by means of temporal stability analyses. Finally, the effect of monitoring frequency on the magnitude of detectable daily soil water content variations was studied. Results showed that soil water content spatial variability followed a bimodal pattern of increasing absolute variability with increasing soil water content. In addition, a linear trend of decreasing soil water content as the distance from the inner part of the terrace increased was identified. Once this trend was subtracted, resulting semi-variograms suggested that the spatial resolution examined was too high to appreciate spatial structuring in the data. Thus, the spatial pattern should be considered as random. Of all the spatial designs tested, the 10 × 10 m mesh grid (9 probes) was considered the most suitable option for a good, time-stable estimate of mean soil water content, as no improvement was obtained with the 5 × 5 m mesh grid (30 probes). Finally, the results of temporal aggregation showed that decreasing the monitoring frequency down to 8 h during wetting-up periods and to 1 day during drying-down ones did not result in a loss of information on daily soil water content variations.

Analysis and trends of precipitation lapse rate and extreme indices over north Sikkim eastern Himalayas under CMIP5ESM-2M RCPs experiments

NASA Astrophysics Data System (ADS)

Singh, Vishal; Goyal, Manish Kumar

2016-01-01

This paper draws attention to highlight the spatial and temporal variability in precipitation lapse rate (PLR) and precipitation extreme indices (PEIs) through the mesoscale characterization of Teesta river catchment, which corresponds to north Sikkim eastern Himalayas. A PLR rate is an important variable for the snowmelt runoff models. In a mountainous region, the PLR could be varied from lower elevation parts to high elevation parts. In this study, a PLR was computed by accounting elevation differences, which varies from around 1500 m to 7000 m. A precipitation variability and extremity were analysed using multiple mathematical functions viz. quantile regression, spatial mean, spatial standard deviation, Mann-Kendall test and Sen's estimation. For this reason, a daily precipitation, in the historical (years 1980-2005) as measured/observed gridded points and projected experiments for the 21st century (years 2006-2100) simulated by CMIP5 ESM-2 M model (Coupled Model Intercomparison Project Phase 5 Earth System Model 2) employing three different radiative forcing scenarios (Representative Concentration Pathways), utilized for the research work. The outcomes of this study suggest that a PLR is significantly varied from lower elevation to high elevation parts. The PEI based analysis showed that the extreme high intensity events have been increased significantly, especially after 2040s. The PEI based observations also showed that the numbers of wet days are increased for all the RCPs. The quantile regression plots showed significant increments in the upper and lower quantiles of the various extreme indices. The Mann-Kendall test and Sen's estimation tests clearly indicated significant changing patterns in the frequency and intensity of the precipitation indices across all the sub-basins and RCP scenario in an intra-decadal time series domain. The RCP8.5 showed extremity of the projected outcomes.

A work-for-food enrichment program increases exploration and decreases stereotypies in four species of bears.

PubMed

Wagman, Jason D; Lukas, Kristen E; Dennis, Patricia M; Willis, Mark A; Carroscia, Joe; Gindlesperger, Curt; Schook, Mandi W

2018-01-01

Zoo-housed bears are prone to exhibiting stereotypic behaviors, generally considered indicators of negative welfare. We explored the effects of a variable-time feeding enrichment schedule on behavioral indicators of welfare in four bear species at Cleveland Metroparks Zoo. We distributed the diets of eight bears in one of five enrichment items, for two consecutive days each, and monitored behavior throughout the day. In Experiment 1, we compared variable-time to fixed-time presentation of enrichment over two, 10-day periods. Overall, bears performed more exploratory behavior when enriched (p < 0.0001). Furthermore, variable-time enrichment was associated with a greater increase in exploratory behavior than fixed-time enrichment when compared to baseline (p < 0.001). Both fixed-time (p unadjusted <0.05, p adjusted = 0.07) and variable-schedule (p unadjusted <0.05, p adjusted = 0.09) enrichment were also associated with similar decreases in abnormal behavior compared to baseline. For Experiment 2, we tested habituation to enrichment over 30 days using multiple items and a semi-variable presentation schedule. Again during the enrichment period, bears exhibited increased exploratory behavior (p < 0.0001) and decreased abnormal behaviors compared to baseline (p unadjusted = 0.05, p adjusted = 0.09). We observed no habituation during the 30-day sustained enrichment period for these behaviors. Collectively, these results suggest that daily, variable-schedule feeding enrichment, with intermittent presentation of unique enrichment items, increases behavioral indicators of positive welfare and decreases behavioral indicators of negative welfare. © 2018 Wiley Periodicals, Inc.

Integrating Solar PV in Utility System Operations: Analytical Framework and Arizona Case Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Jing; Botterud, Audun; Mills, Andrew

2015-06-01

A systematic framework is proposed to estimate the impact on operating costs due to uncertainty and variability in renewable resources. The framework quantifies the integration costs associated with subhourly variability and uncertainty as well as day-ahead forecasting errors in solar PV (photovoltaics) power. A case study illustrates how changes in system operations may affect these costs for a utility in the southwestern United States (Arizona Public Service Company). We conduct an extensive sensitivity analysis under different assumptions about balancing reserves, system flexibility, fuel prices, and forecasting errors. We find that high solar PV penetrations may lead to operational challenges, particularlymore » during low-load and high solar periods. Increased system flexibility is essential for minimizing integration costs and maintaining reliability. In a set of sensitivity cases where such flexibility is provided, in part, by flexible operations of nuclear power plants, the estimated integration costs vary between $1.0 and $4.4/MWh-PV for a PV penetration level of 17%. The integration costs are primarily due to higher needs for hour-ahead balancing reserves to address the increased sub-hourly variability and uncertainty in the PV resource. (C) 2015 Elsevier Ltd. All rights reserved.« less

Frequency-dependent behavior of the barotropic and baroclinic modes of zonal jet variability

NASA Astrophysics Data System (ADS)

Sheshadri, A.; Plumb, R. A.

2016-12-01

Stratosphere-troposphere interactions are frequently described in terms of the leading modes of variability, i.e. the annular modes. An idealized dynamical core model is used to explore the differences between the low- and high- frequency (periods greater and less than 30 days) behavior of the first two principal components of zonal mean zonal wind and eddy kinetic energy, i.e., the barotropic/baroclinic annular modes of variability of the extratropical circulation. The modes show similar spatial characteristics in the different frequency ranges considered, however the ranking of the modes switches in some cases from one range to the other. There is some cancelation in the signatures of eddy heat flux and eddy kinetic energy in the leading low-pass and high-pass filtered zonal wind mode, partly explaining their small signature in the total. At low frequencies, the first zonal wind mode describes latitudinal shifts of both the midlatitude jet and its associated storm tracks, and the persistence of zonal wind anomalies appears to be sustained primarily by a baroclinic, rather than a barotropic, feedback. On shorter time scales, the behavior is more complicated and transient.

[Blood pressure variability and left ventricular hypertrophy in arterial hypertension].

PubMed

Amodeo, C; Martins, S M; Silva Júnior, O; Barros, L M; Batlouni, M; Sousa, J E

1993-05-01

To evaluate the left ventricular hypertrophy correlation with blood pressure variability during day and night time as well as throughout the 24h period. Fifteen patients with mild to moderate essential hypertension underwent to bi-dimensional echocardiographic study and to 24h ambulatory blood pressure monitorization. Left ventricular mass was calculated according to previous validated formulas. The standard deviation of the mean blood pressures during day-time, night-time and 24h period was taken as blood pressure variability indices. The mean age of the group was 42 years old; 9 patients were male and all were white. This study showed that only the systolic and diastolic blood pressure variability during the 24h period correlated significantly with left ventricular mass, (r = 0.53 and p < 0.05; r = 0.58 and p < 0.05 respectively). There was no significant correlation of the day-time and night-time pressures variability with left ventricular mass. The systolic and diastolic blood pressure variability during the 24h period may be one of the many determinants of left ventricular hypertrophy in patients with mild to moderate hypertension.

Coupled nature of evening-time ionospheric electrodynamics

NASA Astrophysics Data System (ADS)

Joshi, L. M.; Tsai, L. C.

2018-04-01

The F region evening electrodynamics in the equatorial region is characterized by a pre-reversal enhancement (PRE) in the zonal eastward electric field. Although the theoretical mechanisms for PRE are known, its variability, particularly day-to-day variability is not fully resolved. PRE is a large scale phenomenon driven by the F region dynamo after the sunset hours. This paper investigates whether the variability of the E region conductivity (particularly the one associated with the sporadic E, Es) has any influence on the F region dynamo and hence on the PRE of zonal electric field. Interestingly, ionosonde observations have indicated a higher occurrence of the blanketing type Es (Esb) over the low latitude on days with highly suppressed PRE of zonal electric field in comparison with the days with significantly larger PRE. Observational evidences presented in this paper suggests that the formation of the Esb in the evening hours is a sovereign process, not always controlled by the sheared F region vertical electric field of equatorial origin, mapping along the magnetic field line on to the low latitude E region. Model computations of the PRE suppression based on the measured Es densities have further substantiated the observational findings presented in this paper. These results clearly indicate that the low latitude Es has the potential to suppress the PRE of zonal electric field and possibly can play a vital role in explaining the PRE variability, particularly the day-to-day variability. Results have been discussed in light of earlier reports on PRE mechanisms and E-F region coupling processes.

The Eocene climate of China, the early elevation of the Tibetan Plateau and the onset of the Asian Monsoon.

PubMed

Wang, Qing; Spicer, Robert A; Yang, Jian; Wang, Yu-Fei; Li, Cheng-Sen

2013-12-01

Eocene palynological samples from 37 widely distributed sites across China were analysed using co-existence approach to determine trends in space and time for seven palaeoclimate variables: Mean annual temperature, mean annual precipitation, mean temperature of the warmest month, mean temperature of the coldest month, mean annual range of temperature, mean maximum monthly precipitation and mean minimum monthly precipitation. Present day distributions and observed climates within China of the nearest living relatives of the fossil forms were used to find the range of a given variable in which a maximum number of taxa can coexist. Isotherm and isohyet maps for the early, middle and late Eocene were constructed. These illustrate regional changing patterns in thermal and precipitational gradients that may be interpreted as the beginnings of the modern Asian Monsoon system, and suggest that the uplift of parts of the Tibetan Plateau appear to have taken place by the middle to late Eocene. © 2013 John Wiley & Sons Ltd.

The search for Infrared radiation prior to major earthquakes

NASA Astrophysics Data System (ADS)

Ouzounov, D.; Taylor, P.; Pulinets, S.

2004-12-01

This work describes our search for a relationship between tectonic stresses and electro-chemical and thermodynamic processes in the Earth and increases in mid-IR flux as part of a possible ensemble of electromagnetic (EM) phenomena that may be related to earthquake activity. Recent analysis of continuous ongoing long- wavelength Earth radiation (OLR) indicates significant and anomalous variability prior to some earthquakes. The cause of these anomalies is not well understood but could be the result of a triggering by an interaction between the lithosphere-hydrosphere and atmospheric related to changes in the near surface electrical field and gas composition prior to the earthquake. The OLR anomaly covers large areas surrounding the main epicenter. We have use the NOAA IR data to differentiate between the global and seasonal variability and these transient local anomalies. Indeed, on the basis of a temporal and spatial distribution analysis, an anomaly pattern is found to occur several days prior some major earthquakes. The significance of these observations was explored using data sets of some recent worldwide events.

Potential of collocated radiometer and wind profiler observations for monsoon studies

NASA Astrophysics Data System (ADS)

Balaji, B.; Prabha, Thara V.; Jaya Rao, Y.; Kiran, T.; Dinesh, G.; Chakravarty, Kaustav; Sonbawne, S. M.; Rajeevan, M.

2017-09-01

Collocated observations from microwave radiometer and wind profiler are used in a pilot study during the monsoon period to derive information on the thermodynamics and winds and association with rainfall characteristics. These instruments were operated throughout the monsoon season of 2015. Continuous vertical profiles of winds, temperature and humidity show significant promise for understanding the low-level jet, its periodicity and its association with moisture transport, clouds and precipitation embedded within the monsoon large-scale convection. Observations showed mutually beneficial in explaining variability that are part of the low frequency oscillations and the diurnal variability during monsoon. These observations highlight the importance of locally driven convective systems, in the presence of weak moisture transport over the area. The episodic moisture convergence showed a periodicity of 9 days which matches with the subsequent convection and precipitation and thermodynamic regimes. Inferences from the diurnal cycle of moisture transport and the convective activity, relationship with the low-level jet characteristics and thermodynamics are also illustrated.

AMBULATORY BLOOD PRESSURE MONITORING: THE NEED OF 7-DAY RECORD

PubMed Central

HALBERG, F.; KATINAS, G.; CORNÉLISSEN, G.; SCHWARTZKOPFF, O.; FIŠER, B.; SIEGELOVÁ, J.; DUŠEK, J.; JANČÍK, J.

2008-01-01

The need for systematic around-the-clock self-measurements of blood pressure (BP) and heart rate (HR), or preferably for automatic monitoring as the need arises and can be met by inexpensive tools, is illustrated in two case reports. Miniaturized unobtrusive, as yet unavailable instrumentation for the automatic measurement of BP and HR should be a high priority for both government and industry. Automatic ambulatorily functioning monitors already represent great progress, enabling us to introduce the concept of eventually continuous or, as yet, intermittent home ABPM. On BP and HR records, gliding spectra aligned with global spectra visualize the changing dynamics involved in health and disease, and can be part of an eventually automated system of therapy adjusted to the ever-present variability of BP. In the interim, with tools already available, chronomics on self- or automatic measurements can be considered, with analyses provided by the Halberg Chronobiology Center, as an alternative to “flying blind”, as an editor put it. Chronomics assessing variability has to be considered. PMID:19018289

A Separable Two-Dimensional Random Field Model of Binary Response Data from Multi-Day Behavioral Experiments.

PubMed

Malem-Shinitski, Noa; Zhang, Yingzhuo; Gray, Daniel T; Burke, Sara N; Smith, Anne C; Barnes, Carol A; Ba, Demba

2018-04-18

The study of learning in populations of subjects can provide insights into the changes that occur in the brain with aging, drug intervention, and psychiatric disease. We introduce a separable two-dimensional (2D) random field (RF) model for analyzing binary response data acquired during the learning of object-reward associations across multiple days. The method can quantify the variability of performance within a day and across days, and can capture abrupt changes in learning. We apply the method to data from young and aged macaque monkeys performing a reversal-learning task. The method provides an estimate of performance within a day for each age group, and a learning rate across days for each monkey. We find that, as a group, the older monkeys require more trials to learn the object discriminations than do the young monkeys, and that the cognitive flexibility of the younger group is higher. We also use the model estimates of performance as features for clustering the monkeys into two groups. The clustering results in two groups that, for the most part, coincide with those formed by the age groups. Simulation studies suggest that clustering captures inter-individual differences in performance levels. In comparison with generalized linear models, this method is better able to capture the inherent two-dimensional nature of the data and find between group differences. Applied to binary response data from groups of individuals performing multi-day behavioral experiments, the model discriminates between-group differences and identifies subgroups. Copyright © 2018. Published by Elsevier B.V.

The response of the natriuretic peptide system to water deprivation in the desert rodent, Notomys alexis.

PubMed

Heimeier, Rachel A; Donald, John A

2006-02-01

Natriuretic peptides (NPs) are regulatory molecules that cause cGMP-mediated diuresis and natriuresis in mammals. Accordingly, it is interesting to consider their role in desert-adapted animals in which water is often limited. This study investigated the response of the natriuretic peptide (NP) system to varying periods of water deprivation (WD) in the Australian desert rodent species, Notomys alexis. It was hypothesised that the expression of the NP system will be down-regulated in water-deprived N. alexis compared to water-replete animals. The plasma levels of ANP were significantly reduced after 3 days of WD, but were unaffected by 7, 14 and 28 days of WD. Water deprivation for 3, 7, 14 days had a variable effect on the mRNA expression of ANP, CNP, NPR-A, NPR-B, and NPR-C, and a uniform down-regulation was not observed. However, after 28 days of WD, mRNA expression was similar to water-replete animals, except for NPR-A. Surprisingly, 7 and 14 days of WD caused an up-regulation in the ability of ANP to stimulate cGMP; this also occurred at 14 days for CNP. Taken together, the mRNA expression and peptide mediated guanylyl cyclase activity data after WD were in the opposite direction to what was predicted. Interestingly, after 28 days of WD, most parameters were similar to those of water-replete animals, which indicates that a down-regulation of the NP system is not part of the physiological response to an absence of free water in N. alexis.

Factors associated with delayed recovery in athletes with concussion treated at a pediatric neurology concussion clinic.

PubMed

Bock, Suzanne; Grim, Rod; Barron, Todd F; Wagenheim, Andrew; Hu, Yaowen Eliot; Hendell, Matthew; Deitch, John; Deibert, Ellen

2015-11-01

With the increase in knowledge and management of sport-related concussion over the last 15 years, there has been a shift from a grading scale approach to an individualized management approach. As a result, there is an increased need to better understand the factors involved in delayed recovery of concussion. The purpose of this retrospective study was to examine factors that may be associated with recovery from sport-related concussion in student athletes aged 11 to 18 years old. Of the 366 patients who met the inclusion criteria, 361 were included in our analysis. The primary dependent variable included days until athlete was able to return to play (RTP). Independent variables of interest included age, gender, academic performance, comorbid factors, sports, on-field markers, days until initial neurological evaluation, Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT®) scores, acute headache rescue medications, chronic headache medication, sleep medication, and referral to concussion rehabilitation program. Variables associated with longer median RTP were being female (35 days), having a referral to concussion rehabilitation program (53 days), being prescribed acute headache rescue therapy (34 days), and having chronic headache treatment (53 days) (all p < 0.05). Variables associated with shorter RTP were on-field marker of headache (23 days) and evaluation within 1 week of concussion by a concussion specialist (16 days) (Both p < 0.05). This study supports the need for a concussed athlete to have access to a provider trained in concussion management in a timely fashion in order to prevent delayed recovery and return to play.

Characterizing the Optical Variability of Bright Blazars: Variability-based Selection of Fermi Active Galactic Nuclei

NASA Astrophysics Data System (ADS)

Ruan, John J.; Anderson, Scott F.; MacLeod, Chelsea L.; Becker, Andrew C.; Burnett, T. H.; Davenport, James R. A.; Ivezić, Željko; Kochanek, Christopher S.; Plotkin, Richard M.; Sesar, Branimir; Stuart, J. Scott

2012-11-01

We investigate the use of optical photometric variability to select and identify blazars in large-scale time-domain surveys, in part to aid in the identification of blazar counterparts to the ~30% of γ-ray sources in the Fermi 2FGL catalog still lacking reliable associations. Using data from the optical LINEAR asteroid survey, we characterize the optical variability of blazars by fitting a damped random walk model to individual light curves with two main model parameters, the characteristic timescales of variability τ, and driving amplitudes on short timescales \\hat{\\sigma }. Imposing cuts on minimum τ and \\hat{\\sigma } allows for blazar selection with high efficiency E and completeness C. To test the efficacy of this approach, we apply this method to optically variable LINEAR objects that fall within the several-arcminute error ellipses of γ-ray sources in the Fermi 2FGL catalog. Despite the extreme stellar contamination at the shallow depth of the LINEAR survey, we are able to recover previously associated optical counterparts to Fermi active galactic nuclei with E >= 88% and C = 88% in Fermi 95% confidence error ellipses having semimajor axis r < 8'. We find that the suggested radio counterpart to Fermi source 2FGL J1649.6+5238 has optical variability consistent with other γ-ray blazars and is likely to be the γ-ray source. Our results suggest that the variability of the non-thermal jet emission in blazars is stochastic in nature, with unique variability properties due to the effects of relativistic beaming. After correcting for beaming, we estimate that the characteristic timescale of blazar variability is ~3 years in the rest frame of the jet, in contrast with the ~320 day disk flux timescale observed in quasars. The variability-based selection method presented will be useful for blazar identification in time-domain optical surveys and is also a probe of jet physics.

Working the Indian Field Days: The Economy of Authenticity and the Question of Agency in Yosemite Valley

ERIC Educational Resources Information Center

Cothran, Boyd

2010-01-01

Originally conceived by National Park Service (NPS) officials as a way to "revive and maintain the interest of Indians in their own games and industries," the Yosemite Indian Field Days were part rodeo, part pageant, and part craft fair. Through its activities, the Field Days offered white tourists the opportunity to encounter…

Temperature, routine activities, and domestic violence: a reanalysis.

PubMed

Rotton, J; Cohn, E G

2001-04-01

It was hypothesized that base rate differences in the number of complaints made during daylight and nighttime hours were responsible for a previously reported, nonlinear relationship between temperature and domestic violence. This hypothesis was tested by subjecting calls for service in 1987 and 1988 in Minneapolis, to moderator-variable regression analyses with controls for time of day, day of the week, season, and their interactions as well as linear trend, major holidays, public school closings, the first day of the month, and other weather variables. Temporal variables explained 75% of the variance in calls for service. As hypothesized, the base rate artifact was responsible for an apparent downturn in violence at high temperatures: Fewer complaints were received during afternoon hours, because they happen to be the warmest time of the day. The results were interpreted in terms of routine activity theory.

Near 7-day response of ocean bottom pressure to atmospheric surface pressure and winds in the northern South China Sea

NASA Astrophysics Data System (ADS)

Zhang, Kun; Zhu, Xiao-Hua; Zhao, Ruixiang

2018-02-01

Ocean bottom pressures, observed by five pressure-recording inverted echo sounders (PIESs) from October 2012 to July 2014, exhibit strong near 7-day variability in the northern South China Sea (SCS) where long-term in situ bottom pressure observations are quite sparse. This variability was strongest in October 2013 during the near two years observation period. By joint analysis with European Center for Medium-Range Weather Forecasts (ECMWF) data, it is shown that the near 7-day ocean bottom pressure variability is closely related to the local atmospheric surface pressure and winds. Within a period band near 7 days, there are high coherences, exceeding 95% significance level, of observed ocean bottom pressure with local atmospheric surface pressure and with both zonal and meridional components of the wind. Ekman pumping/suction caused by the meridional component of the wind in particular, is suggested as one driving mechanism. A Kelvin wave response to the near 7-day oscillation would propagate down along the continental slope, observed at the Qui Nhon in the Vietnam. By multiple and partial coherence analyses, we find that local atmospheric surface pressure and Ekman pumping/suction show nearly equal influence on ocean bottom pressure variability at near 7-day periods. A schematic diagram representing an idealized model gives us a possible mechanism to explain the relationship between ocean bottom pressure and local atmospheric forcing at near 7-day periods in the northern SCS.

Gap winds and their effects on regional oceanography Part II: Kodiak Island, Alaska

NASA Astrophysics Data System (ADS)

Ladd, Carol; Cheng, Wei; Salo, Sigrid

2016-10-01

Frequent gap winds, defined here as offshore-directed flow channeled through mountain gaps, have been observed near Kodiak Island in the Gulf of Alaska (GOA). Gap winds from the Iliamna Lake gap were investigated using QuikSCAT wind data. The influence of these wind events on the regional ocean was examined using satellite and in situ data combined with Regional Ocean Modeling System (ROMS) model runs. Gap winds influence the entire shelf width (> 200 km) northeast of Kodiak Island and extend an additional 150 km off-shelf. Due to strong gradients in the along-shelf direction, they can result in vertical velocities in the ocean of over 20 m d-1 due to Ekman pumping. The wind events also disrupt flow of the Alaska Coastal Current (ACC), resulting in decreased flow down Shelikof Strait and increased velocities on the outer shelf. This disruption of the ACC has implications for freshwater transport into the Bering Sea. The oceanographic response to gap winds may influence the survival of larval fishes as Arrowtooth Flounder recruitment is negatively correlated with the interannual frequency of gap-wind events, and Pacific Cod recruitment is positively correlated. The frequency of offshore directed winds exhibits a strong seasonal cycle averaging 7 days per month during winter and 2 days per month during summer. Interannual variability is correlated with the Pacific North America Index and shows a linear trend, increasing by 1.35 days per year. An accompanying paper discusses part I of our study (Ladd and Cheng, 2016) focusing on gap-wind events flowing out of Cross Sound in the eastern GOA.

Consumption of meat and fish and risk of lung cancer: results from the European Prospective Investigation into Cancer and Nutrition.

PubMed

Linseisen, Jakob; Rohrmann, Sabine; Bueno-de-Mesquita, Bas; Büchner, Frederike L; Boshuizen, Hendriek C; Agudo, Antonio; Gram, Inger Torhild; Dahm, Christina C; Overvad, Kim; Egeberg, Rikke; Tjønneland, Anne; Boeing, Heiner; Steffen, Annika; Kaaks, Rudolf; Lukanova, Annekatrin; Berrino, Franco; Palli, Domenico; Panico, Salvatore; Tumino, Rosario; Ardanaz, Eva; Dorronsoro, Miren; Huerta, José-Maria; Rodríguez, Laudina; Sánchez, María-José; Rasmuson, Torgny; Hallmans, Göran; Manjer, Jonas; Wirfält, Elisabet; Engeset, Dagrun; Skeie, Guri; Katsoulis, Michael; Oikonomou, Eleni; Trichopoulou, Antonia; Peeters, Petra H M; Khaw, Kay-Tee; Wareham, Nicholas; Allen, Naomi; Key, Tim; Brennan, Paul; Romieu, Isabelle; Slimani, Nadia; Vergnaud, Anne-Claire; Xun, Wei W; Vineis, Paolo; Riboli, Elio

2011-06-01

Evidence from case-control studies, but less so from cohort studies, suggests a positive association between meat intake and risk of lung cancer. Therefore, this association was evaluated in the frame of the European Prospective Investigation into Cancer and Nutrition, EPIC. Data from 478,021 participants, recruited from 10 European countries, who completed a dietary questionnaire in 1992-2000 were evaluated; 1,822 incident primary lung cancer cases were included in the present evaluation. Relative risk estimates were calculated for categories of meat intake using multi-variably adjusted Cox proportional hazard models. In addition, the continuous intake variables were calibrated by means of 24-h diet recall data to account for part of the measurement error. There were no consistent associations between meat consumption and the risk of lung cancer. Neither red meat (RR = 1.06, 95% CI 0.89-1.27 per 50 g intake/day; calibrated model) nor processed meat (RR = 1.13, 95% CI 0.95-1.34 per 50 g/day; calibrated model) was significantly related to an increased risk of lung cancer. Also, consumption of white meat and fish was not associated with the risk of lung cancer. These findings do not support the hypothesis that a high intake of red and processed meat is a risk factor for lung cancer.

A multi-agency nutrient dataset used to estimate loads, improve monitoring design, and calibrate regional nutrient SPARROW models

USGS Publications Warehouse

Saad, David A.; Schwarz, Gregory E.; Robertson, Dale M.; Booth, Nathaniel

2011-01-01

Stream-loading information was compiled from federal, state, and local agencies, and selected universities as part of an effort to develop regional SPAtially Referenced Regressions On Watershed attributes (SPARROW) models to help describe the distribution, sources, and transport of nutrients in streams throughout much of the United States. After screening, 2,739 sites, sampled by 73 agencies, were identified as having suitable data for calculating long-term mean annual nutrient loads required for SPARROW model calibration. These sites had a wide range in nutrient concentrations, loads, and yields, and environmental characteristics in their basins. An analysis of the accuracy in load estimates relative to site attributes indicated that accuracy in loads improve with increases in the number of observations, the proportion of uncensored data, and the variability in flow on observation days, whereas accuracy declines with increases in the root mean square error of the water-quality model, the flow-bias ratio, the number of days between samples, the variability in daily streamflow for the prediction period, and if the load estimate has been detrended. Based on compiled data, all areas of the country had recent declines in the number of sites with sufficient water-quality data to compute accurate annual loads and support regional modeling analyses. These declines were caused by decreases in the number of sites being sampled and data not being entered in readily accessible databases.

Socio-Ecological Variables Associated with Context-Specific Sitting Time in Belgian Older Adults: A One-Year Follow-Up Study

PubMed Central

Busschaert, Cedric; Scherrens, Anne-Lore; De Bourdeaudhuij, Ilse; Cardon, Greet; Van Cauwenberg, Jelle; De Cocker, Katrien

2016-01-01

Introduction Knowledge about variables associated with context-specific sitting time in older adults is limited. Therefore, this study explored cross-sectional and longitudinal associations of socio-demographic, social-cognitive, physical-environmental and health-related variables with sitting during TV viewing, computer use and motorized transport in older adults. Methods A sample of Belgian older adults completed structured interviews on context-specific sitting time and associated variables using a longitudinal study design. Objective measurements of grip strength and physical performance were also completed. Complete baseline data were available of 258 participants (73.98±6.16 years) of which 229 participants remained in the study at one year follow-up (retention rate: 91.60%). Cross-sectional correlates (baseline data) and longitudinal predictors (change-scores in relation with change in sitting time) were explored through multiple linear regression analyses. Results Per context-specific sitting time, most of the cross-sectional correlates differed from the longitudinal predictors. Increases over time in enjoyment of watching TV (+one unit), encouragement of partner to watch less TV (+one unit) and TV time of partner (+30.0 min/day) were associated with respectively 9.1 min/day (p<0.001), 16.0 min/day (p<0.001) and 12.0 min/day (p<0.001) more sitting during TV viewing at follow-up. Increases over time in enjoyment of using a computer (+one unit), the number of smartphones and tablets (+1) and computer use of the partner (+30.0 min/day) were associated with respectively 5.5 min/day (p < .01), 10.4 min/day (p < .05) and 3.0 min/day (p < .05) more sitting during computer use at follow-up. An increase over time in self-efficacy regarding taking a bicycle or walking was associated with 2.9 min/day (p < .05) less sitting during motorized transport at follow-up. Conclusions The results stressed the importance of looking at separate contexts of sitting. Further, the results highlighted the importance of longitudinal research in order to reveal which changes in particular variables predicted changes in context-specific sitting time. Variables at the social-cognitive level were most frequently related to context-specific sitting. PMID:27997603

Calcium and nitrogen balance, experiment M007

NASA Technical Reports Server (NTRS)

Whedon, G. D.; Lutwak, L.; Neuman, W. F.; Lachance, P. A.

1971-01-01

The collection of data on the response of the skeletal and muscular systems to 14-day space flights was evaluated for loss of calcium, nitrogen, and other metabolically related elements. Considerable interindividual variability was demonstrated in all experimental factors that were measured. Calcium balance became less positive and urinary phosphate excretion increased substantially in flight despite a reduction in phosphate intake. Patterns of excretion of magnesium, sodium, potassium, and chloride were different for each subject, and, in part, could be correlated with changes in adrenocortical steroid production. The principal hormonal change was a striking decrease during flight in the urinary excretion of 17-hydroxycortocosteroids. Dermal losses of calcium, magnesium, sulfate, and phosphate were insignificant during all three phases.

Prior hospitalization and age as predictors of mental health resource utilization in Israel.

PubMed

Ginsberg, G; Lerner, Y; Mark, M; Popper, M

1997-03-01

A two-part demand model based on data from a psychiatric case registry was estimated in order to search for predictors of hospital-based psychiatric care utilization. Using only age as an independent variable, explanation of future resource utilization is considerably weaker than when number of cumulative days of psychiatric hospital-based service use during the previous five years is also included. Only a small marginal gain is achieved by also adding diagnoses. Prospective remuneration by capitating sick funds according to age and past hospital-based service utilization records is recommended to avoid the twin pitfalls of cream-skimming and a distorted allocation of resources for psychiatric services.

Effects of Meteorological Variables on the Incidence of Rupture of Intracranial Aneurysms in Central New Jersey.

PubMed

Kellogg, Marissa; Petrov, Dimitriy; Agarwal, Nitin; Patel, Nitesh V; Hansberry, David Richard; Agarwal, Prateek; Brimacombe, Michael; Gandhi, Chirag D; Prestigiacomo, Charles

2017-05-01

Introduction  Previous studies have suggested relationships between the rupture of intracranial aneurysms and meteorological variables such as season, barometric pressure, and temperature. Our objective was to examine the relationship between the incidence of hospital admissions secondary to aneurysmal subarachnoid hemorrhage (aSAH) and meteorological variables in central New Jersey. Methods  The study population consisted of 312 patients who presented to University Hospital in Newark, New Jersey, between January 1, 2003, and December 31, 2008, with aSAH. Days in the 6-year period were classified as nonbleed days (no aSAH), bleed days (one or more aSAHs within 1 calendar day), cluster days (two or more aSAHs within 2 calendar days), and multiple-bleed days (two or more aSAHs within 1 calendar day). Results  The only significant meteorological risk factor for the occurrence of multiple-bleed days was high barometric pressure (1018.5 versus 1016.5 millibars [mbars]; p <  0.04), but an increase in barometric pressure (+ 2.8 mbars) over the 2 days prior to the multiple-bleed day, although not statistically significant, may be a risk factor ( p <  0.09). Barometric pressure was also noted to be increased on bleed days (1017.2 versus 1016.5 mbars) and cluster days (1017.7 versus 1016.5 mbars), but this relationship was not significant ( p <  0.1 and p <  0.1, respectively). Although aSAH days demonstrated consistently lower temperatures than non-aSAH days and dropping temperatures were consistently found in the days preceding the aSAH, these relationships were not significant. Conclusion  Among meteorological factors, high barometric pressure and low temperature may be risk factors for the onset of aSAH. Georg Thieme Verlag KG Stuttgart · New York.

Variability and repeatability analysis of plantar pressure during gait in older people.

PubMed

Franco, Pedro S; Silva, Caio Borella P da; Rocha, Emmanuel S da; Carpes, Felipe P

2015-01-01

Repeatability and variability of the plantar pressure during walking are important components in the clinical assessment of the elderly. However, there is a lack of information on the uniformity of plantar pressure patterns in the elderly. To analyze the repeatability and variability in plantar pressure considering mean, peak and asymmetries during aged gait. Plantar pressure was monitored in four different days for ten elderly subjects (5 female), with mean±standard-deviation age of 73±6 years, walking barefoot at preferred speed. Data were compared between steps for each day and between different days. Mean and peak plantar pressure values were similar between the different days of evaluation. Asymmetry indexes were similar between the different days evaluated. Plantar pressure presented a consistent pattern in the elderly. However, the asymmetry indexes observed suggest that the elderly are exposed to repetitive asymmetric loading during locomotion. Such result requires further investigation, especially concerning the role of these asymmetries for development of articular injuries. Copyright © 2015 Elsevier Editora Ltda. All rights reserved.

Microlensing and Intrinsic Variability of the Broad Emission Lines of Lensed Quasars

NASA Astrophysics Data System (ADS)

Fian, C.; Guerras, Eduardo; Mediavilla, E.; Jiménez-Vicente, J.; Muñoz, J. A.; Falco, E. E.; Motta, V.; Hanslmeier, A.

2018-05-01

We study the broad emission lines in a sample of 11 gravitationally lensed quasars with at least two epochs of observation to identify intrinsic variability and to disentangle it from microlensing. To improve our statistical significance and emphasize trends, we also include 15 lens systems with single-epoch spectra. Mg II and C III] emission lines are only weakly affected by microlensing, but C IV shows strong microlensing in some cases, even for regions of the line core, presumably associated with small projected velocities. However, excluding the strongly microlensed cases, there is a strikingly good match, on average, between the red wings of the C IV and C III] profiles. Analysis of these results supports the existence of two regions in the broad-line region (BLR), one that is insensitive to microlensing (of size ≳50 lt-day and kinematics not confined to a plane) and another that shows up only when it is magnified by microlensing (of size of a few light-days, comparable to the accretion disk). Both regions can contribute in different proportions to the emission lines of different species and, within each line profile, to different velocity bins, all of which complicates detailed studies of the BLR based on microlensing size estimates. The strength of the microlensing indicates that some spectral features that make up the pseudo-continuum, such as the shelf-like feature at λ1610 or several Fe III blends, may in part arise from an inner region of the accretion disk. In the case of Fe II, microlensing is strong in some blends but not in others. This opens up interesting possibilities to study quasar accretion disk kinematics. Intrinsic variability seems to affect the same features prone to microlensing, with similar frequency and amplitude, but does not induce outstanding profile asymmetries. We measure intrinsic variability (≲20%) of the wings with respect to the cores in the C IV, C III], and Mg II lines consistent with reverberation mapping studies.

Stroke patients' functions in personal activities of daily living in relation to sleep and socio-demographic and clinical variables in the acute phase after first-time stroke and at six months of follow-up.

PubMed

Bakken, Linda N; Kim, Hesook S; Finset, Arnstein; Lerdal, Anners

2012-07-01

To explore first-time stroke patients' degree of independence in activities of daily life in relation to sleep and other essential variables that might influence activities of daily life. Sleep has received little attention in rehabilitation of activities of daily life in stroke patients. This is a longitudinal survey and observational study design from the acute phase to six months poststroke. First-time stroke patients (n = 90) were recruited from two hospitals in eastern Norway in 2007 and 2008. Data were collected by survey interview, medical records and wrist actigraphy in the first two weeks at the hospital and at six months of follow-up. Actigraph measures patient activity and estimates sleep during the day and night. Linear regression showed that high dependence in personal activities of daily living was directly related to low estimated sleep time at night and higher estimated sleep during the day in the acute phase, controlling for socio-demographic and clinical variables. Furthermore, high estimated numbers of awakenings in the acute phase were related to lower activities of daily life functioning at six months of follow-up after controlling for socio-demographic and clinical variables. Stronger pain and a lower physical functioning showed direct relationships with lower independency level of in activities of daily life both in the acute phase and after six months. Sleep patterns in the acute phase may influence the patients' activities of daily life functioning up to six months poststroke. Furthermore, pain in the acute phase may influence the level of activities of daily life functioning in stroke patients. Nurses should pay attention to stroke patients' sleep quality and pain in the rehabilitation period after a stroke. Facilitating good sleep conditions and screening for pain should be an integral part of the rehabilitation programme. © 2012 Blackwell Publishing Ltd.

Seasonal variation and meteotropism in various self-rated psychological and physiological features of a normal couple

NASA Astrophysics Data System (ADS)

Maes, Michael; de Meyer, Frans; Peeters, Dirk; Meltzer, Herbert; Cosyns, Paul; Schotte, Chris

1992-12-01

Recently, true seasonal variation with significant periodicities (circannual, semiannual, circatrimensual, circabimensual) and a significant meteotropism have been observed in a number of self-rated characteristics of normal man (arousal, mood, physiology and social behaviour). In order to replicate these findings, two normal controls (a married couple) were asked daily to complete a self-rating scale concerned with the characteristics mentioned above during one calendar year. By means of time series analysis, significant rhythmicities with recurrent cycles in the autorhythmometric data of all of the above characteristics were found. An important part of the variance in these characteristics was found, using multiple regression, to be related to various weather variables, such as mean atmospheric pressure, temperature, relative humidity, wind speed, minutes of sunlight/day and precipitation/day. These results support the hypothesis that temporal variations in human psychological and physiological characteristics may be dictated by the composite effects of past and present atmospheric activity.

Weekly cycles of global fires—Associations with religion, wealth and culture, and insights into anthropogenic influences on global climate

NASA Astrophysics Data System (ADS)

Earl, Nick; Simmonds, Ian; Tapper, Nigel

2015-11-01

One approach to quantifying anthropogenic influences on the environment and the consequences of those is to examine weekly cycles (WCs). No long-term natural process occurs on a WC so any such signal can be considered anthropogenic. There is much ongoing scientific debate as to whether regional-scale WCs exist above the statistical noise level, with most significant studies claiming that anthropogenic aerosols and their interaction with solar radiation and clouds (direct/indirect effect) is the controlling factor. A major source of anthropogenic aerosol, underrepresented in the literature, is active fire (AF) from anthropogenic burning for land clearance/management. WCs in AF have not been analyzed heretofore, and these can provide a mechanism for observed regional-scale WCs in several meteorological variables. We show that WCs in AFs are highly pronounced for many parts of the world, strongly influenced by the working week and particularly the day(s) of rest, associated with religious practices.

Socioeconomic factors and heavy drinking over the course of the week among job seekers with at-risk alcohol use.

PubMed

Haberecht, Katja; Baumann, Sophie; Gaertner, Beate; John, Ulrich; Freyer-Adam, Jennis

2018-05-04

This article investigates the influence of socioeconomic factors on heavy drinking over the course of the week. As part of a randomized controlled trial, 1,282 job seekers with at-risk alcohol use were systematically recruited at 3 job agencies and reported number of drinks consumed on each day in the past week. Latent growth curve models were calculated to represent variations of alcohol use. School education and duration of lifetime unemployment were tested as predictors; sociodemographic variables were integrated as covariates. A weekly pattern was confirmed in the total sample: constant low alcohol use on working days, escalation on Friday, and a further increase on weekends. Significant associations between longer duration of lifetime unemployment and higher initial alcohol use on Sundays (p < .001) and less increase on Fridays (p = .001) disappeared after controlling for sociodemographic factors. Longer duration of lifetime unemployment does not appear to affect alcohol use trajectories over the course of the week.

Variability in Antibiotic Use Across PICUs.

PubMed

Brogan, Thomas V; Thurm, Cary; Hersh, Adam L; Gerber, Jeffrey S; Smith, Michael J; Shah, Samir S; Courter, Joshua D; Patel, Sameer J; Parker, Sarah K; Kronman, Matthew P; Lee, Brian R; Newland, Jason G

2018-06-01

To characterize and compare antibiotic prescribing across PICUs to evaluate the degree of variability. Retrospective analysis from 2010 through 2014 of the Pediatric Health Information System. Forty-one freestanding children's hospital. Children aged 30 days to 18 years admitted to a PICU in children's hospitals contributing data to Pediatric Health Information System. To normalize for potential differences in disease severity and case mix across centers, a subanalysis was performed of children admitted with one of the 20 All Patient Refined-Diagnosis Related Groups and the seven All Patient Refined-Diagnosis Related Groups shared by all PICUs with the highest antibiotic use. The study included 3,101,201 hospital discharges from 41 institutions with 386,914 PICU patients. All antibiotic use declined during the study period. The median-adjusted antibiotic use among PICU patients was 1,043 days of therapy/1,000 patient-days (interquartile range, 977-1,147 days of therapy/1,000 patient-days) compared with 893 among non-ICU children (interquartile range, 805-968 days of therapy/1,000 patient-days). For PICU patients, the median adjusted use of broad-spectrum antibiotics was 176 days of therapy/1,000 patient-days (interquartile range, 152-217 days of therapy/1,000 patient-days) and was 302 days of therapy/1,000 patient-days (interquartile range, 220-351 days of therapy/1,000 patient-days) for antimethicillin-resistant Staphylococcus aureus agents, compared with 153 days of therapy/1,000 patient-days (interquartile range, 130-182 days of therapy/1,000 patient-days) and 244 days of therapy/1,000 patient-days (interquartile range, 203-270 days of therapy/1,000 patient-days) for non-ICU children. After adjusting for potential confounders, significant institutional variability existed in antibiotic use in PICU patients, in the 20 All Patient Refined-Diagnosis Related Groups with the highest antibiotic usage and in the seven All Patient Refined-Diagnosis Related Groups shared by all 41 PICUs. The wide variation in antibiotic use observed across children's hospital PICUs suggests inappropriate antibiotic use.

Identifying environmental variables explaining genotype-by-environment interaction for body weight of rainbow trout (Onchorynchus mykiss): reaction norm and factor analytic models.

PubMed

Sae-Lim, Panya; Komen, Hans; Kause, Antti; Mulder, Han A

2014-02-26

Identifying the relevant environmental variables that cause GxE interaction is often difficult when they cannot be experimentally manipulated. Two statistical approaches can be applied to address this question. When data on candidate environmental variables are available, GxE interaction can be quantified as a function of specific environmental variables using a reaction norm model. Alternatively, a factor analytic model can be used to identify the latent common factor that explains GxE interaction. This factor can be correlated with known environmental variables to identify those that are relevant. Previously, we reported a significant GxE interaction for body weight at harvest in rainbow trout reared on three continents. Here we explore their possible causes. Reaction norm and factor analytic models were used to identify which environmental variables (age at harvest, water temperature, oxygen, and photoperiod) may have caused the observed GxE interaction. Data on body weight at harvest was recorded on 8976 offspring reared in various locations: (1) a breeding environment in the USA (nucleus), (2) a recirculating aquaculture system in the Freshwater Institute in West Virginia, USA, (3) a high-altitude farm in Peru, and (4) a low-water temperature farm in Germany. Akaike and Bayesian information criteria were used to compare models. The combination of days to harvest multiplied with daily temperature (Day*Degree) and photoperiod were identified by the reaction norm model as the environmental variables responsible for the GxE interaction. The latent common factor that was identified by the factor analytic model showed the highest correlation with Day*Degree. Day*Degree and photoperiod were the environmental variables that differed most between Peru and other environments. Akaike and Bayesian information criteria indicated that the factor analytical model was more parsimonious than the reaction norm model. Day*Degree and photoperiod were identified as environmental variables responsible for the strong GxE interaction for body weight at harvest in rainbow trout across four environments. Both the reaction norm and the factor analytic models can help identify the environmental variables responsible for GxE interaction. A factor analytic model is preferred over a reaction norm model when limited information on differences in environmental variables between farms is available.

Identifying environmental variables explaining genotype-by-environment interaction for body weight of rainbow trout (Onchorynchus mykiss): reaction norm and factor analytic models

PubMed Central

2014-01-01

Background Identifying the relevant environmental variables that cause GxE interaction is often difficult when they cannot be experimentally manipulated. Two statistical approaches can be applied to address this question. When data on candidate environmental variables are available, GxE interaction can be quantified as a function of specific environmental variables using a reaction norm model. Alternatively, a factor analytic model can be used to identify the latent common factor that explains GxE interaction. This factor can be correlated with known environmental variables to identify those that are relevant. Previously, we reported a significant GxE interaction for body weight at harvest in rainbow trout reared on three continents. Here we explore their possible causes. Methods Reaction norm and factor analytic models were used to identify which environmental variables (age at harvest, water temperature, oxygen, and photoperiod) may have caused the observed GxE interaction. Data on body weight at harvest was recorded on 8976 offspring reared in various locations: (1) a breeding environment in the USA (nucleus), (2) a recirculating aquaculture system in the Freshwater Institute in West Virginia, USA, (3) a high-altitude farm in Peru, and (4) a low-water temperature farm in Germany. Akaike and Bayesian information criteria were used to compare models. Results The combination of days to harvest multiplied with daily temperature (Day*Degree) and photoperiod were identified by the reaction norm model as the environmental variables responsible for the GxE interaction. The latent common factor that was identified by the factor analytic model showed the highest correlation with Day*Degree. Day*Degree and photoperiod were the environmental variables that differed most between Peru and other environments. Akaike and Bayesian information criteria indicated that the factor analytical model was more parsimonious than the reaction norm model. Conclusions Day*Degree and photoperiod were identified as environmental variables responsible for the strong GxE interaction for body weight at harvest in rainbow trout across four environments. Both the reaction norm and the factor analytic models can help identify the environmental variables responsible for GxE interaction. A factor analytic model is preferred over a reaction norm model when limited information on differences in environmental variables between farms is available. PMID:24571451

Reconstruction and analysis of erythemal UV radiation time series from Hradec Králové (Czech Republic) over the past 50 years

NASA Astrophysics Data System (ADS)

Čížková, Klára; Láska, Kamil; Metelka, Ladislav; Staněk, Martin

2018-02-01

This paper evaluates the variability of erythemal ultraviolet (EUV) radiation from Hradec Králové (Czech Republic) in the period 1964-2013. The EUV radiation time series was reconstructed using a radiative transfer model and additional empirical relationships, with the final root mean square error of 9.9 %. The reconstructed time series documented the increase in EUV radiation doses in the 1980s and the 1990s (up to 15 % per decade), which was linked to the steep decline in total ozone (10 % per decade). The changes in cloud cover were the major factor affecting the EUV radiation doses especially in the 1960s, 1970s, and at the beginning of the new millennium. The mean annual EUV radiation doses in the decade 2004-2013 declined by 5 %. The factors affecting the EUV radiation doses differed also according to the chosen integration period (daily, monthly, and annually): solar zenith angle was the most important for daily doses, cloud cover, and surface UV albedo for their monthly means, and the annual means of EUV radiation doses were most influenced by total ozone column. The number of days with very high EUV radiation doses increased by 22 % per decade, the increase was statistically significant in all seasons except autumn. The occurrence of the days with very high EUV doses was influenced mostly by low total ozone column (82 % of days), clear-sky or partly cloudy conditions (74 % of days) and by increased surface albedo (19 % of days). The principal component analysis documented that the occurrence of days with very high EUV radiation doses was much affected by the positive phase of North Atlantic Oscillation with an Azores High promontory reaching over central Europe. In the stratosphere, a strong Arctic circumpolar vortex and the meridional inflow of ozone-poor air from the southwest were favorable for the occurrence of days with very high EUV radiation doses. This is the first analysis of the relationship between the high EUV radiation doses and macroscale circulation patterns, and therefore more attention should be given also to other dynamical variables that may affect the solar UV radiation on the Earth surface.

Geosat crossover analysis in the tropical Pacific. Part 1: Constrained sinusoidal crossover adjustment

NASA Technical Reports Server (NTRS)

Tai, Chang-Kou

1988-01-01

A new method (constrained sinusoidal crossover adjustment) for removing the orbit error in satellite altimetry is tested (using crossovers accumulated in the first 91 days of the Geosat non-repeat era in the tropical Pacific) and found to have excellent qualities. Two features distinguish the new method from the conventional bias-and-tilt crossover adjustment. First, a sine wave (with wavelength equaling the circumference of the Earth) is used to represent the orbit error for each satellite revolution, instead of the bias-and-tilt (and curvature, if necessary) approach for each segment of the satellite ground track. Secondly, the indeterminacy of the adjustment process is removed by a simple constraint minimizing the amplitudes of the sine waves, rather than by fixing selected tracks. Overall the new method is more accurate, more efficient, and much less cumbersome than the old. The idea of restricting the crossover adjustment to crossovers between tracks that are less than certain days apart in order to preserve the large-scale long-term oceanic variability is also tested with inconclusive results because the orbit error was unusually nonstationary in the initial 91 days of the GEOSAT mission.

Global Magnetic Variability at Planetary Wave Periods

NASA Astrophysics Data System (ADS)

Forbes, J. M.; Behm, J.

2017-12-01

Planetary waves (PW) and PW-tide interactions are thought to introduce multi-day periodicities ( 2-20 days) in the electric fields and currents induced by the wind dynamo mechanism in the ionospheric E-region (ca. 100-150 km), and thus can provide important insights on coupling between the lower atmosphere and the ionosphere. Previous studies have used a relatively small subset of available data to infer the existence of these variations in ground magnetic measurements. In some cases connections were made with contemporaneous measurements of neutral wind dynamics. In the present work, we employ ground-based magnetometer data from over 100 stations from the INTERMAGNET network during 2009 to gain a global perspective on eastward- and westward-propagating and zonally-symmetric oscillations with PW periods. Our presentation describes how the unevenly-spaced global data are re-gridded onto an icosahedral grid prior to analysis, and assesses how gaps in the distribution of points across the grid affect extraction of some parts of the spectrum. Consideration is also given to possible contamination by recurrent magnetic activity at subharmonics of 27 days. The global evolution of several PW components during 2009 are depicted and interpreted.

Exploring the spatio-temporal relationship between two key aeroallergens and meteorological variables in the United Kingdom

NASA Astrophysics Data System (ADS)

Khwarahm, Nabaz; Dash, Jadunandan; Atkinson, Peter M.; Newnham, R. M.; Skjøth, C. A.; Adams-Groom, B.; Caulton, Eric; Head, K.

2014-05-01

Constructing accurate predictive models for grass and birch pollen in the air, the two most important aeroallergens, for areas with variable climate conditions such as the United Kingdom, require better understanding of the relationships between pollen count in the air and meteorological variables. Variations in daily birch and grass pollen counts and their relationship with daily meteorological variables were investigated for nine pollen monitoring sites for the period 2000-2010 in the United Kingdom. An active pollen count sampling method was employed at each of the monitoring stations to sample pollen from the atmosphere. The mechanism of this method is based on the volumetric spore traps of Hirst design (Hirst in Ann Appl Biol 39(2):257-265, 1952). The pollen season (start date, finish date) for grass and birch were determined using a first derivative method. Meteorological variables such as daily rainfall; maximum, minimum and average temperatures; cumulative sum of Sunshine duration; wind speed; and relative humidity were related to the grass and birch pollen counts for the pre-peak, post peak and the entire pollen season. The meteorological variables were correlated with the pollen count data for the following temporal supports: same-day, 1-day prior, 1-day mean prior, 3-day mean prior, 7-day mean prior. The direction of influence (positive/negative) of meteorological variables on pollen count varied for birch and grass, and also varied when the pollen season was treated as a whole season, or was segmented into the pre-peak and post-peak seasons. Maximum temperature, sunshine duration and rainfall were the most important variables influencing the count of grass pollen in the atmosphere. Both maximum temperature (pre-peak) and sunshine produced a strong positive correlation, and rain produced a strong negative correlation with grass pollen count in the air. Similarly, average temperature, wind speed and rainfall were the most important variables influencing the count of birch pollen in the air. Both wind speed and rain produced a negative correlation with birch pollen count in the air and average temperature produced a positive correlation.

Planning, Supervision and Quality of Instructional Leadership of Girls' Day Secondary Schools in Kaduna State, Nigeria

ERIC Educational Resources Information Center

Duruh, Benjamin C.

2018-01-01

This study investigated the Planning, Supervision and Quality of Instructional Leadership of Girls' Day Secondary Schools in Kaduna State. The research design adopted was a survey design. The independent variables were the respondents which include principals, teachers, students, parents and government officials while dependent variable includes…

Comparison of two methods for estimating base flow in selected reaches of the South Platte River, Colorado

USGS Publications Warehouse

Capesius, Joseph P.; Arnold, L. Rick

2012-01-01

The Mass Balance results were quite variable over time such that they appeared suspect with respect to the concept of groundwater flow as being gradual and slow. The large degree of variability in the day-to-day and month-to-month Mass Balance results is likely the result of many factors. These factors could include ungaged stream inflows or outflows, short-term streamflow losses to and gains from temporary bank storage, and any lag in streamflow accounting owing to streamflow lag time of flow within a reach. The Pilot Point time series results were much less variable than the Mass Balance results and extreme values were effectively constrained. Less day-to-day variability, smaller magnitude extreme values, and smoother transitions in base-flow estimates provided by the Pilot Point method are more consistent with a conceptual model of groundwater flow being gradual and slow. The Pilot Point method provided a better fit to the conceptual model of groundwater flow and appeared to provide reasonable estimates of base flow.

Alveolar Molding Effect in Infants With Unilateral Cleft Lip and Palate: Comparison of Two- and Three-Dimensional Measurements.

PubMed

Lim, Won Hee; Park, Eun Woo; Chae, Hwa Sung; Kwon, Soon Man; Jung, Hoi-In; Baek, Seung-Hak

2017-06-01

The purpose of this study was to compare the results of two- (2D) and three-dimensional (3D) measurements for the alveolar molding effect in patients with unilateral cleft lip and palate. The sample consisted of 23 unilateral cleft lip and palate infants treated with nasoalveolar molding (NAM) appliance. Dental models were fabricated at initial visit (T0; mean age, 23.5 days after birth) and after alveolar molding therapy (T1; mean duration, 83 days). For 3D measurement, virtual models were constructed using a laser scanner and 3D software. For 2D measurement, 1:1 ratio photograph images of dental models were scanned by a scanner. After setting of common reference points and lines for 2D and 3D measurements, 7 linear and 5 angular variables were measured at the T0 and T1 stages, respectively. Wilcoxon signed rank test and Bland-Altman analysis were performed for statistical analysis. The alveolar molding effect of the maxilla following NAM treatment was inward bending of the anterior part of greater segment, forward growth of the lesser segment, and decrease in the cleft gap in the greater segment and lesser segment. Two angular variables showed difference in statistical interpretation of the change by NAM treatment between 2D and 3D measurements (ΔACG-BG-PG and ΔACL-BL-PL). However, Bland-Altman analysis did not exhibit significant difference in the amounts of change in these variables between the 2 measurements. These results suggest that the data from 2D measurement could be reliably used in conjunction with that from 3D measurement.

Understanding the relationship between the variability in agrometeorological indices and adaptation practices across the Canadian Prairies

NASA Astrophysics Data System (ADS)

Chipanshi, A.; Qi, D.; Zhang, Y.; Cherneski, P.

2017-12-01

In an attempt to understand how agriculture will adapt to the changing and variable climate, crop based agrometeorological indices including the Effective Growing Degree Days (EGDDs), Growing Season Length (GSL), Heat waves, Water Demand (Precipitation - Evapotranspiration) and the Standardized Precipitation Evapotranspiration Index (SPEI) were analyzed in terms of frequency, duration and trend over a 63-year timeframe (1950 to 2012) from the Canadian Prairies and related to crop production. The heat based indices (EGDD, GSL and Heat waves) increased over the analysis period due to an upward increase in the observed mean temperature. The change was most noticeable in the northern portion of the study area where agriculture is limited by insufficient heat units under the present climate. Heat waves became more frequent in the southern parts of the study area (there were more days above the 30oC threshold). Water availability as assessed from water demand (P-PE) and SPEI trended downward especially in Alberta and Saskatchewan. In spite of the increased severity and frequency in water deficits, there was a noticeable reduction in the variability of crop yield over time. This was attributed to the increased adaptive capacity that has been gained through the use of improved seed hybrids, fertilizer, the use of fungicides and adoption of best management practices such as zero till and direct seeding. After crop yields were de-trended to remove effects of technology, the cumulative precipitation during the growing season explained the majority of the variance in crop yield. This initial analysis has set the stage for analyzing the characteristics of agrometeorological indices under climate change scenarios and how accumulated precipitation during the growing season will affect crop yield and production.

Determinants for return to work among sickness certified patients in general practice.

PubMed

von Celsing, Anna-Sophia; Svärdsudd, Kurt; Eriksson, Hans-G; Björkegren, Karin; Eriksson, Margaretha; Wallman, Thorne

2012-12-14

Long-term sickness absence is one of the main risk factors for permanent exit out of the labour market. Early identification of the condition is essential to facilitate return to work. The aim of this study was to analyse possible determinants of return to work and their relative impact. All 943 subjects aged 18 to 63 years, sickness certified at a Primary Health Care Centre in Sweden from 1 January until 31 August 2004, were followed up for three years. Baseline information on sex, age, sick leave diagnosis, employment status, extent of sick leave, and sickness absence during the year before baseline was obtained, as was information on all compensated days of sick leave, disability pension and death during follow-up. Slightly more than half the subjects were women, mean age was 39 years. Half of the study population returned to work within 14 days after baseline, and after three years only 15 subjects were still on sick leave. In multivariate proportional hazards regression analysis the extent of previous sick leave, age, being on part-time sick leave, and having a psychiatric, musculoskeletal, cardiovascular, nervous disease, digestive system, or injury or poisoning diagnosis decreased the return to work rate, while being employed increased it. Marital status, sex, being born in Sweden, citizenship, and annual salary had no influence. In logistic regression analyses across follow-up time these variables altogether explained 88-90% of return to work variation. Return to work was positively or negatively associated by a number of variables easily accessible in the GP's office. Track record data in the form of previous sick leave was the most influential variable.

Ethnic differences in blood pressure, pulse rate, and related characteristics in young adults. The CARDIA study.

PubMed

Liu, K; Ballew, C; Jacobs, D R; Sidney, S; Savage, P J; Dyer, A; Hughes, G; Blanton, M M

1989-08-01

This study examined ethnic differences in blood pressure and pulse rate in young adults to see whether the differences, if they exist, can be explained by differences in body mass index, lifestyle, psychological, and socioeconomic characteristics. Data used were from the baseline examination of the Coronary Artery Risk Development in (Young) Adults Study (CARDIA). CARDIA is a longitudinal study of lifestyle and evolution of cardiovascular disease risk factors in 5,116 young adults, black and white, men and women, aged 18-30 years, of varying socioeconomic status. Young black adults had higher mean systolic blood pressure and slightly higher mean diastolic blood pressure than young white adults. For both men and women, the blood pressure differences between blacks and whites tended to be greater for the age group 25-30 than for the age group 18-24 years. Among the variables studied, body mass index, duration of exercise on the treadmill, number of cigarettes smoked per day, and number of alcoholic drinks per week were consistently associated with blood pressure. The blood pressure differences were greatly reduced after adjusting for these variables. Black participants had lower mean pulse rate than white participants. The differences tended to be greater for the age group 18-24 than for the age group 25-30 years. Among the variables studied, only duration on treadmill and number of cigarettes smoked per day were consistently correlated with pulse rate. With adjustment for duration on treadmill, the differences in pulse rate increased. These results suggest that differences in ethnic pattern of blood pressures and pulse rate with age may be due in part to obesity, physical fitness, alcohol consumption, and cigarette smoking.

Simulation of saltwater movement in the Upper Floridan aquifer in the Savannah, Georgia-Hilton Head Island, South Carolina, area, predevelopment-2004, and projected movement for 2000 pumping conditions

USGS Publications Warehouse

Provost, Alden M.; Payne, Dorothy F.; Voss, Clifford I.

2006-01-01

A digital model was developed to simulate ground-water flow and solute transport for the Upper Floridan aquifer in the Savannah, Georgia-Hilton Head Island, South Carolina, area. The model was used to (1) simulate trends of saltwater intrusion from predevelopment to the present day (1885-2004), (2) project these trends from the present day into the future, and (3) evaluate the relative influence of different assumptions regarding initial and boundary conditions and physical properties. The model is based on a regional, single-density ground-water flow model of coastal Georgia and adjacent parts of South Carolina and Florida. Variable-density ground-water flow and solute transport were simulated using the U.S. Geological Survey finite-element, variable-density solute-transport simulator SUTRA, 1885-2004. The model comprises seven layers: the surficial aquifer system, the Brunswick aquifer system, the Upper Floridan aquifer, the Lower Floridan aquifer, and the intervening confining units. The model was calibrated to September 1998 water levels, for single-density freshwater conditions, then refined using variable density and chloride concentration to give a reasonable match to the trend in the chloride distribution in the Upper Floridan aquifer inferred from field measurements of specific conductance made during 2000, 2002, 2003, and 2004. The model was modified to simulate solute transport by allowing saltwater to enter the system through localized areas near the northern end of Hilton Head Island, at Pinckney Island, and near the Colleton River, and was calibrated to match chloride concentrations inferred from field measurements of specific conductance. This simulation is called the 'Base Case.'

Provider-Hospital “Fit” and Patient Outcomes: Evidence from Massachusetts Cardiac Surgeons, 2002–2004

PubMed Central

Huesch, Marco D

2011-01-01

Objective To examine whether the “fit” of a surgeon with hospital resources impacts cardiac surgery outcomes, separately from hospital or surgeon effects. Data Sources Retrospective secondary data from the Massachusetts Department of Public Health's Data Analysis Center, on all 12,983 adult isolated coronary artery bypass surgical admissions in state-regulated hospitals from 2002 through 2004. Clinically audited chart data was collected using Society of Thoracic Surgeons National Cardiac Surgery Database tools and cross-referenced with administrative discharge data in the Division of Health Care Finance and Policy. Mortality was followed up through 2007 via the state vital statistics registry. Study Design Analysis was at the patient level for those receiving isolated coronary artery bypass surgery (CABG). Sixteen outcomes included 30-day mortality, major morbidity, indicators of perioperative, and predischarge processes of care. Hierarchical crossed mixed models were used to estimate fixed covariate and random effects at hospital, surgeon, and hospital × surgeon level. Principal Findings Hospital volume was associated with significantly reduced intraoperative durations and significantly increased probability of aspirin, β-blocker, and lipid-lowering discharge medication use. The proportion of outcome variability due to unobserved hospital × surgeon interaction effects was small but meaningful for intraoperative practices, discharge destination, and medication use. For readmissions and mortality within 30 days or 1 year, unobserved patient and hospital factors drove almost all variability in outcomes. Conclusions Among Massachusetts patients receiving isolated CABG, consistent evidence was found that the hospital × surgeon combination independently impacted patient outcomes, beyond hospital or surgeon effects. Such distinct local interactions between a surgeon and hospital resources may play an important part in moderating quality improvement efforts, although residual patient-level factors generally contributed the most to outcome variability. PMID:20849555

Local and Catchment-Scale Water Storage Changes in Northern Benin Deduced from Gravity Monitoring at Various Time-Scales

NASA Astrophysics Data System (ADS)

Hinderer, J.; Hector, B.; Séguis, L.; Descloitres, M.; Cohard, J.; Boy, J.; Calvo, M.; Rosat, S.; Riccardi, U.; Galle, S.

2013-12-01

Water storage changes (WSC) are investigated by the mean of gravity monitoring in Djougou, northern Benin, in the frame of the GHYRAF (Gravity and Hydrology in Africa) project. In this area, WSC are 1) part of the control system for evapotranspiration (ET) processes, a key variable of the West-African monsoon cycle and 2) the state variable for resource management, a critical issue in storage-poor hard rock basement contexts such as in northern Benin. We show the advantages of gravity monitoring for analyzing different processes in the water cycle involved at various time and space scales, using the main gravity sensors available today (FG5 absolute gravimeter, superconducting gravimeter -SG- and CG5 micro-gravimeter). The study area is also part of the long-term observing system AMMA-Catch, and thus under intense hydro-meteorological monitoring (rain, soil moisture, water table level, ET ...). Gravity-derived WSC are compared at all frequencies to hydrological data and to hydrological models calibrated on these data. Discrepancies are analyzed to discuss the pros and cons of each approach. Fast gravity changes (a few hours) are significant when rain events occur, and involve different contributions: rainfall itself, runoff, fast subsurface water redistribution, screening effect of the gravimeter building and local topography. We investigate these effects and present the statistical results of a set of rain events recorded with the SG installed in Djougou since July 2010. The intermediate time scale of gravity changes (a few days) is caused by ET and both vertical and horizontal water redistribution. The integrative nature of gravity measurements does not allow to separate these different contributions, and the screening from the shelter reduces our ability to retrieve ET values. Also, atmospheric corrections are critical at such frequencies, and deserve some specific attention. However, a quick analysis of gravity changes following rain events shows that the values are in accordance with expected ET values (up to about 5mm/day). Seasonal WSC are analyzed since 2008 using FG5 absolute gravity measurements four times a year and since 2010 using the continuous SG time series. They can reach up to 12 microGal (≈270mm) and show a clear interannual variability, as can be expected from rainfall variability in the area. This data set allows some estimates of an average specific yield for the local aquifer, together with a scaling factor for Magnetic Resonance Soundings-derived water content.

Day-to-day variability in spot urine albumin-creatinine ratio.

PubMed

Naresh, Chetana N; Hayen, Andrew; Weening, Alexander; Craig, Jonathan C; Chadban, Steven J

2013-12-01

Accurate quantification of albuminuria is important in the diagnosis and management of chronic kidney disease. The reference test, a timed urinary albumin excretion, is cumbersome and prone to collection errors. Spot urine albumin-creatinine ratio (ACR) is convenient and commonly used, but random day-to-day variability in ACR measurements has not been assessed. Prospective cohort study of day-to-day variability in spot urine ACR measurements. Clinically stable outpatients (N = 157) attending a university hospital clinic in Australia between July 2007 and April 2010. Spot urine ACR variability was assessed and repeatability limits were determined using fractional polynomials. ACRs were measured from spot urine samples collected at 9:00 am on consecutive days and 24-hour urine albuminuria was measured concurrently. Paired ACRs were obtained from 157 patients (median age, 56 years; 60% men; median daily albumin excretion, 226 [range, 2.5-14,000] mg/d). Day-to-day variability was substantial and increased in absolute terms, but decreased in relative terms, with increasing baseline ACR. For patients with normoalbuminuria (ACR < 3 mg/mmol [<27 mg/g]), a change greater than ±467% (0-17 mg/mmol [0-150 mg/g]) is required to indicate a significant change in albuminuria status with 95% certainty; for those with microalbuminuria (ACR of 3-30 mg/mmol [27-265 mg/g]), a change of ±170% (0-27 mg/mmol [0-239 mg/g]) is required; for those with macroalbuminuria (ACR > 30 mg/mmol [>265 mg/g]), a change of ±83% (5-55 mg/mmol [44-486 mg/g]) is required; and for those with nephrotic-range proteinuria (ACR > 300 mg/mmol [>2,652 mg/g]), a change of ±48% (158-443 mg/mmol [1,397-3,916 mg/g]) is needed to represent a significant change. These study results need to be replicated in other ethnic groups. Changes in chronic kidney disease status attributed to therapy or disease progression, when based solely on a change in ACR, may be incorrect unless the potential for day-to-day biological variation has been considered. Only relatively large changes are likely to indicate a change in disease status. Copyright © 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

A comparative analysis of health-related quality of life for residents of U.S. counties with and without coal mining.

PubMed

Zullig, Keith J; Hendryx, Michael

2010-01-01

We compared health-related quality of life (HRQOL) in mining and non-mining counties in and out of Appalachia using the 2006 Behavioral Risk Factor Surveillance System (BRFSS) survey. Dependent variables included self-rated health, the number of poor physical and mental health days, the number of activity limitation days (in the last 30 days), and the Centers for Disease Control and Prevention Healthy Days Index. Independent variables included the presence of coal mining, Appalachian region residence, metropolitan status, primary care physician supply, and BRFSS behavioral (e.g., smoking, body mass index, and alcohol consumption) and demographic (e.g., age, gender, race, and income) variables. We compared dependent variables across a four-category variable: Appalachia (yes/ no) and coal mining (yes/no). We used SUDAAN Multilog and multiple linear regression models with post-hoc least-squares means to test for Appalachian coal-mining effects after adjusting for covariates. Residents of coal-mining counties inside and outside of Appalachia reported significantly fewer healthy days for both physical and mental health, and poorer self-rated health (p < 0.0005) when compared with referent U.S. non-coal-mining counties, but disparities were greatest for people residing in Appalachian coal-mining areas. Furthermore, results remained consistent in separate analyses by gender and age. Coal-mining areas are characterized by greater socioeconomic disadvantage, riskier health behaviors, and environmental degradation that are associated with reduced HRQOL.

Age Effects on Hypocotyl Mechanics.

PubMed

Saxe, Friederike; Weichold, Susann; Reinecke, Antje; Lisec, Jan; Döring, Anett; Neumetzler, Lutz; Burgert, Ingo; Eder, Michaela

2016-01-01

Numerous studies deal with composition and molecular processes involved in primary cell wall formation and alteration in Arabidopsis. However, it still remains difficult to assess the relation between physiological properties and mechanical function at the cell wall level. The thin and fragile structure of primary cell walls and their large biological variability, partly related to structural changes during growth, make mechanical experiments challenging. Since, to the best of our knowledge, there is no reliable data in the literature about how the properties of the fully elongated zone of hypocotyls change with age. We studied in a series of experiments on two different seed batches the tensile properties the region below the growth zone of 4 to 7 day old etiolated Arabidopsis hypocotyls. Additionally, we analysed geometrical parameters, hypocotyl density and cellulose content as individual traits and their relation to tissue mechanics. No significant differences of the mechanical parameters of the non-growing region between 5-7 day old plants could be found whereas in 4 day old plants both tensile stiffness and ultimate tensile stress were significantly lower than in the older plants. Furthermore hypocotyl diameters and densities remain almost the same for 5, 6 and 7 day old seedlings. Naturally, hypocotyl lengths increase with age. The evaluation whether the choice-age or length-influences the mechanical properties showed that both are equally applicable sampling parameters. Additionally, our detailed study allows for the estimation of biological variability, connections between mechanics and hypocotyl age could be established and complement the knowledge on biochemistry and genetics affecting primary plant cell wall growth. The application of two different micromechanical devices for testing living Arabidopsis hypocotyls allows for emphasizing and discussing experimental limitations and for presenting a wide range of possibilities to address current and future questions related to plant cell wall mechanics, synthesis and growth in combination with molecular biology methodologies.

24 h urinary free cortisol in large-scale epidemiological studies: short-term and long-term stability and sources of variability.

PubMed

Rosmalen, Judith G M; Kema, Ido P; Wüst, Stefan; van der Ley, Claude; Visser, Sipke T; Snieder, Harold; Bakker, Stephan J L

2014-09-01

Function of the hypothalamus-pituitary-adrenal (HPA) axis has been associated with several somatic and psychiatric health problems. The amount of free cortisol excreted in the urine during 24h (24-h UFC) has often been used as a proxy for HPA-axis function. Reference values for 24-h UFC and their stability in the short and long term, as well as sources of variability, are largely lacking. This study was performed in a general population cohort. Participants collected 24-h UFC on two consecutive days (T1), and repeated this collection approximately 2 years later (T2). Cortisol in urine was measured using LC-MS/MS. Height and weight were measured at the research facilities; glomerular filtration rate was estimated using creatinine clearance. Psychological distress (General Health Questionnaire), smoking, alcohol use and exercise were measured by means of questionnaires. 24-h UFC stability on a day-to-day basis was 0.69 (T1, N=1192) and 0.72 (T2, N=963) (both p<0.001). Long-term stability as indicated by correlation between 2-day averages of T1 and T2 was 0.60 (N=972, p<0.001). Multivariable linear regression analysis revealed that 24-h UFC was predicted by urine volume (standardized beta 0.282 (T1, N=1556) and 0.276 (T2, N=1244); both p<0.001) and glomerular filtration rate (standardized beta 0.137 (T1) and 0.179 (T2); both p<0.001), while also sex explained a small part (standardized beta for female sex -0.057 (T1) and -0.080 (T2); both p<0.05). 24-h UFC is moderately stable both in the short and the long term. The effects of urine volume and glomerular filtration rate on 24-h UFC are much stronger than those of sex. Copyright © 2014 Elsevier Ltd. All rights reserved.

The influence of changing UVB radiation in near-surface ozone time series

NASA Astrophysics Data System (ADS)

BröNnimann, Stefan; Voigt, Stefan; Wanner, Heinz

2000-04-01

UVB radiation plays an important role in tropospheric photochemistry since it determines the rate of ozone photolysis J(O1D) and subsequent formation of OH radicals. Consequently, changes of UVB radiation, for example due to changes of the stratospheric ozone amount, could alter the concentration of reactive tropospheric gases including ozone. An observation-based attempt is made to quantify the effect of changing UVB radiation on surface ozone peaks on a day-to-day scale using a time series of measurements at a Swiss mountain site. Seven years data of ozone, NO, NOx, and meteorological measurements from Chaumont (1140 m above sea level (asl)), total ozone and UVB measurements from Arosa (1847 m asl), and surface albedo from satellite observations are investigated. The study is restricted to fair weather days with moderately high NOx concentrations. Multiple regression analysis is performed using chemical, meteorological, and UV dependent variables to predict afternoon ozone peaks. From autumn to spring, positive deviations of ozone peaks are clearly connected with positive UVB deviations. The relation is statistically significant only in part of the seasonal data subsets; however, it is consistent with model studies. The estimated net effect on ozone peaks is normally within a range of 4 ppb, a range of about 6 ppb is predicted for large UVB changes. Applying the coefficients for the large interannual variability of the stratospheric ozone layer observed in spring in the last 10 years results in a range of variation of at most 1 to 1.5 ppb for monthly mean ozone peaks. For trends of J(O1D) from 1970 to 1990, a trend bias of surface ozone peaks on polluted fair weather days of less than 0.12 ppb/yr is calculated. Although the numbers are rather small, they may play a role in certain circumstances.

Development of heat and drought related extreme weather events and their effect on winter wheat yields in Germany

NASA Astrophysics Data System (ADS)

Lüttger, Andrea B.; Feike, Til

2018-04-01

Climate change constitutes a major challenge for high productivity in wheat, the most widely grown crop in Germany. Extreme weather events including dry spells and heat waves, which negatively affect wheat yields, are expected to aggravate in the future. It is crucial to improve the understanding of the spatiotemporal development of such extreme weather events and the respective crop-climate relationships in Germany. Thus, the present study is a first attempt to evaluate the historic development of relevant drought and heat-related extreme weather events from 1901 to 2010 on county level (NUTS-3) in Germany. Three simple drought indices and two simple heat stress indices were used in the analysis. A continuous increase in dry spells over time was observed over the investigated periods from 1901-1930, 1931-1960, 1961-1990 to 2001-2010. Short and medium dry spells, i.e., precipitation-free periods longer than 5 and 8 days, respectively, increased more strongly compared to longer dry spells (longer than 11 days). The heat-related stress indices with maximum temperatures above 25 and 28 °C during critical wheat growth phases showed no significant increase over the first three periods but an especially sharp increase in the final 1991-2010 period with the increases being particularly pronounced in parts of Southwestern Germany. Trend analysis over the entire 110-year period using Mann-Kendall test revealed a significant positive trend for all investigated indices except for heat stress above 25 °C during flowering period. The analysis of county-level yield data from 1981 to 2010 revealed declining spatial yield variability and rather constant temporal yield variability over the three investigated (1981-1990, 1991-2000, and 2001-2010) decades. A clear spatial gradient manifested over time with variability in the West being much smaller than in the east of Germany. Correlating yield variability with the previously analyzed extreme weather indices revealed strong spatiotemporal fluctuations in explanatory power of the different indices over all German counties and the three time periods. Over the 30 years, yield deviations were increasingly well correlated with heat and drought-related indices, with the number of days with maximum temperature above 25 °C during anthesis showing a sharp increase in explanatory power over entire Germany in the final 2001-2010 period.

Day-to-day variability in spot urine protein-creatinine ratio measurements.

PubMed

Naresh, Chetana N; Hayen, Andrew; Craig, Jonathan C; Chadban, Steven J

2012-10-01

Accurate measurement of proteinuria is important in the diagnosis and management of chronic kidney disease (CKD). The reference standard test, 24-hour urinary protein excretion, is inconvenient and vulnerable to collection errors. Spot urine protein-creatinine ratio (PCR) is a convenient alternative and is in widespread use. However, day-to-day variability in PCR measurements has not been evaluated. Prospective cohort study of day-to-day variability in spot urine PCR measurement. Clinically stable outpatients with CKD (n = 145) attending a university hospital CKD clinic in Australia between July 2007 and April 2010. Spot urine PCR. Spot PCR variability was assessed and repeatability limits were determined using fractional polynomials. Spot PCRs were measured from urine samples collected at 9:00 am on consecutive days and 24-hour urinary protein excretion was collected concurrently. Paired results were analyzed from 145 patients: median age, 56 years; 59% men; and median 24-hour urinary protein excretion, 0.7 (range, 0.06-35.7) g/d. Day-to-day variability was substantial and increased in absolute terms, but decreased in relative terms with increasing baseline PCR. For patients with a low baseline PCR (20 mg/mmol [177 mg/g]), a change greater than ±160% (repeatability limits, 0-52 mg/mmol [0-460 mg/g]) is required to indicate a real change in proteinuria status with 95% certainty, whereas for those with a high baseline PCR (200 mg/mmol [1,768 mg/g]), a change of ±50% (decrease to <100 mg/mmol [<884 mg/g] or increase to >300 mg/mmol [>2,652 mg/g]) represents significant change. These study results need to be replicated in other ethnic groups. Changes in PCR observed in patients with CKD, ranging from complete resolution to doubling of PCR values, could be due to inherent biological variation and may not indicate a change in disease status. This should be borne in mind when using PCR in the diagnosis and management of CKD. Copyright © 2012 National Kidney Foundation, Inc. All rights reserved.

A randomized, double-blind, placebo-controlled trial of safinamide as add-on therapy in early Parkinson's disease patients.

PubMed

Stocchi, Fabrizio; Borgohain, Rupam; Onofrj, Marco; Schapira, Anthony H V; Bhatt, Mohit; Lucini, Valentina; Giuliani, Rodolfo; Anand, Ravi

2012-01-01

Safinamide is an α-aminoamide with both dopaminergic and nondopaminergic mechanisms of action evaluated as an add-on to dopamine agonist (DA) therapy in early-stage PD. In this 24-week, double-blind study, patients with early PD receiving a stable dose of a single DA were randomized to once-daily safinamide 100 mg, safinamide 200 mg, or placebo. The primary efficacy variable was UPDRS part III (motor examination) total score. Analysis was hierarchical: 200 mg of safinamide versus placebo was tested first; the success of safinamide 100 mg versus placebo was contingent on this. Two hundred sixty-nine patients received safinamide 100 mg (n = 90), safinamide 200 mg (n = 89), or placebo (n = 90); 70, 81, and 81 patients, respectively, completed the study. Mean improvements from baseline to week 24 in UPDRS III total scores were -3.90 for safinamide 200 mg, -6.0 for safinamide 100 mg and -3.60 for placebo. The difference between safinamide 200 mg and placebo was not significant [point estimate: -0.4; 95% confidence interval (CI): -2.3-1.4; P = 0.6504]. Although the difference between 100 mg/day and placebo was significant (point estimate: -1.9; 95% CI: -3.7 to -0.1; P = 0.0419), these results are considered exploratory. No clinically meaningful differences from placebo were observed for any safety variables. This study did not demonstrate a significant improvement of the primary endpoint for safinamide 200 mg/day. Exploratory analysis of the primary endpoint for 100 mg/day demonstrated that the addition of safinamide to a stable dose of DA improves motor symptoms in early PD and warrants further investigation. Copyright © 2011 Movement Disorder Society.

Discontinuity of Medicaid Coverage: Impact on Cost and Utilization Among Adult Medicaid Beneficiaries With Major Depression.

PubMed

Ji, Xu; Wilk, Adam S; Druss, Benjamin G; Lally, Cathy; Cummings, Janet R

2017-08-01

Gaps in Medicaid coverage may disrupt access to and continuity of care. This can be detrimental for beneficiaries with chronic conditions, such as major depression, for whom disruptions in access to outpatient care may lead to increased use of acute care. However, little is known about how Medicaid coverage discontinuities impact acute care utilization among adults with depression. Examine the relationship between Medicaid discontinuities and service utilization among adults with major depression. A total of 139,164 adults (18-64) with major depression was identified using the 2003-2004 Medicaid Analytic eXtract Files. We used generalized linear and two-part models to examine the effect of Medicaid discontinuity on service utilization. To establish causality in this relationship, we used instrumental variables analysis, relying on exogenous variation in a state-level policy for identification. Emergency department (ED) visits, inpatient episodes, inpatient days, and Medicaid-reimbursed costs. Approximately 29.4% of beneficiaries experienced coverage disruptions. In instrumental variables models, those with coverage disruptions incurred an increase of $650 in acute care costs per-person per Medicaid-covered month compared with those with continuous coverage, evidenced by an increase in ED use (0.1 more ED visits per-person-month) and inpatient days (0.6 more days per-person-month). The increase in acute costs contributed to an overall increase in all-cause costs by $310 per-person-month (all P-values<0.001). Among depressed adults, those experiencing coverage disruptions have, on average, significantly greater use of costly ED/inpatient services than those with continuous coverage. Maintenance of continuous Medicaid coverage may help prevent acute episodes requiring high-cost interventions.

The temporal spectrum of adult mosquito population fluctuations: conceptual and modeling implications.

PubMed

Jian, Yun; Silvestri, Sonia; Brown, Jeff; Hickman, Rick; Marani, Marco

2014-01-01

An improved understanding of mosquito population dynamics under natural environmental forcing requires adequate field observations spanning the full range of temporal scales over which mosquito abundance fluctuates in natural conditions. Here we analyze a 9-year daily time series of uninterrupted observations of adult mosquito abundance for multiple mosquito species in North Carolina to identify characteristic scales of temporal variability, the processes generating them, and the representativeness of observations at different sampling resolutions. We focus in particular on Aedes vexans and Culiseta melanura and, using a combination of spectral analysis and modeling, we find significant population fluctuations with characteristic periodicity between 2 days and several years. Population dynamical modelling suggests that the observed fast fluctuations scales (2 days-weeks) are importantly affected by a varying mosquito activity in response to rapid changes in meteorological conditions, a process neglected in most representations of mosquito population dynamics. We further suggest that the range of time scales over which adult mosquito population variability takes place can be divided into three main parts. At small time scales (indicatively 2 days-1 month) observed population fluctuations are mainly driven by behavioral responses to rapid changes in weather conditions. At intermediate scales (1 to several month) environmentally-forced fluctuations in generation times, mortality rates, and density dependence determine the population characteristic response times. At longer scales (annual to multi-annual) mosquito populations follow seasonal and inter-annual environmental changes. We conclude that observations of adult mosquito populations should be based on a sub-weekly sampling frequency and that predictive models of mosquito abundance must include behavioral dynamics to separate the effects of a varying mosquito activity from actual changes in the abundance of the underlying population.

Impacts of Climate Change on the Timing of the Production Season of Maple Syrup in Eastern Canada

PubMed Central

Côté, Benoît; Logan, Travis; Power, Hugues; Charron, Isabelle; Duchesne, Louis

2015-01-01

Maple syrup production is an important economic activity in north-eastern North-America. The beginning and length of the production season is linked to daily variation in temperature. There are increasing concerns about the potential impact of climatic change on this industry. Here, we used weekly data of syrup yield for the 1999–2011 period from 121 maple stands in 11 regions of Québec (Canada) to predict how the period of production may be impacted by climate warming. The date at which the production begins is highly variable between years with an average range of 36 days among the regions. However, the average start date for a given region, which ranged from Julian day 65 to 83, was highly predictable (r2 = 0.88) using the average temperature from January to April (TJ-A). A logistic model predicting the weekly presence or absence of production was also developed. Using the inputs of 77 future climate scenarios issued from global models, projections of future production timing were made based on average TJ-A and on the logistic model. The projections of both approaches were in very good agreement and suggest that the sap season will be displaced to occur 15–19 days earlier on average in the 2080–2100 period. The data also show that the displacement in time will not be accompanied by a greater between years variability in the beginning of the season. However, in the southern part of Québec, very short periods of syrup production due to unfavourable conditions in the spring will occur more frequently in the future although their absolute frequencies will remain low. PMID:26682889

Impacts of Climate Change on the Timing of the Production Season of Maple Syrup in Eastern Canada.

PubMed

Houle, Daniel; Paquette, Alain; Côté, Benoît; Logan, Travis; Power, Hugues; Charron, Isabelle; Duchesne, Louis

2015-01-01

Maple syrup production is an important economic activity in north-eastern North-America. The beginning and length of the production season is linked to daily variation in temperature. There are increasing concerns about the potential impact of climatic change on this industry. Here, we used weekly data of syrup yield for the 1999-2011 period from 121 maple stands in 11 regions of Québec (Canada) to predict how the period of production may be impacted by climate warming. The date at which the production begins is highly variable between years with an average range of 36 days among the regions. However, the average start date for a given region, which ranged from Julian day 65 to 83, was highly predictable (r2 = 0.88) using the average temperature from January to April (TJ-A). A logistic model predicting the weekly presence or absence of production was also developed. Using the inputs of 77 future climate scenarios issued from global models, projections of future production timing were made based on average TJ-A and on the logistic model. The projections of both approaches were in very good agreement and suggest that the sap season will be displaced to occur 15-19 days earlier on average in the 2080-2100 period. The data also show that the displacement in time will not be accompanied by a greater between years variability in the beginning of the season. However, in the southern part of Québec, very short periods of syrup production due to unfavourable conditions in the spring will occur more frequently in the future although their absolute frequencies will remain low.

Volatile organic compound measurements at Trinidad Head, California, during ITCT 2K2: Analysis of sources, atmospheric composition, and aerosol residence times

NASA Astrophysics Data System (ADS)

Millet, Dylan B.; Goldstein, Allen H.; Allan, James D.; Bates, Timothy S.; Boudries, Hacene; Bower, Keith N.; Coe, Hugh; Ma, Yilin; McKay, Megan; Quinn, Patricia K.; Sullivan, Amy; Weber, Rodney J.; Worsnop, Douglas R.

2004-12-01

We report hourly in-situ observations of C1-C8 speciated volatile organic compounds (VOCs) obtained at Trinidad Head CA in April and May 2002 as part of the NOAA Intercontinental Transport and Chemical Transformation study. Factor analysis of the VOC data set was used to define the dominant processes driving atmospheric chemical composition at the site, and to characterize the sources for measured species. Strong decreases in background concentration were observed for several of the VOCs during the experiment due to seasonal changes in OH concentration. CO was the most important contributor to the total measured OH reactivity at the site at all times. Oxygenated VOCs were the primary component of both the total VOC burden and of the VOC OH reactivity, and their relative importance was enhanced under conditions when local source contributions were minimal. VOC variability exhibited a strong dependence on residence time (slnX = 1.55τ-0.44, r2 = 0.98; where slnX is the standard deviation of the natural logarithm of the mixing ratio), and this relationship was used, in conjunction with measurements of 222Rn, to estimate the average OH concentration during the study period (6.1 × 105 molec/cm3). We also employed the variability-lifetime relationship defined by the VOC data set to estimate submicron aerosol residence times as a function of chemical composition. Two independent measures of aerosol chemical composition yielded consistent residence time estimates. Lifetimes calculated in this manner were between 3-7 days for aerosol nitrate, organics, sulfate, and ammonium. The lifetime estimate for methane sulfonic acid (˜12 days) was slightly outside of this range. The lifetime of the total aerosol number density was estimated at 9.8 days.

Summer precipitation variability over South America on long and short intraseasonal timescales

NASA Astrophysics Data System (ADS)

Gonzalez, Paula L. M.; Vera, Carolina S.

2014-10-01

A dipole pattern in convection between the South Atlantic convergence zone and the subtropical plains of southeastern South America characterizes summer intraseasonal variability over the region. The dipole pattern presents two main bands of temporal variability, with periods between 10 and 30 days, and 30 and 90 days; each influenced by different large-scale dynamical forcings. The dipole activity on the 30-90-day band is related to an eastward traveling wavenumber-1 structure in both OLR and circulation anomalies in the tropics, similar to that associated with the Madden-Julian oscillation. The dipole is also related to a teleconnection pattern extended along the South Pacific between Australia and South America. Conversely, the dipole activity on the 10-30-day band does not seem to be associated with tropical convection anomalies. The corresponding circulation anomalies exhibit, in the extratropics, the structure of Rossby-like wave trains, although their sources are not completely clear.

Did the ancient egyptians discover Algol?

NASA Astrophysics Data System (ADS)

Jetsu, L.; Porceddu, S.; Porceddu, S.; Lyytinen, J.; Kajatkari, P.; Markkanen, T.; Toivari-Viitala, J.

2013-02-01

Fabritius discovered the first variable star, Mira, in 1596. Holwarda determined the 11 months period of Mira in 1638. Montanari discovered the next variable star, Algol, in 1669. Its period, 2.867 days, was determined by Goodricke (178). Algol was associated with demon-like creatures, "Gorgon" in ancient Greek and "ghoul" in ancient Arab mythology. This indicates that its variability was discovered much before 1669 (Wilk 1996), but this mythological evidence is ambiguous (Davis 1975). For thousands of years, the Ancient Egyptian Scribes (AES) observed stars for timekeeping in a region, where there are nearly 300 clear nights a year. We discovered a significant periodicity of 2.850 days in their calendar for lucky and unlucky days dated to 1224 BC, "the Cairo Calendar". Several astrophysical and astronomical tests supported our conclusion that this was the period of Algol three millennia ago. The "ghoulish habits" of Algol could explain this 0.017 days period increase (Battersby 2012).

Improved short-term variability in the thermosphere-ionosphere-mesosphere-electrodynamics general circulation model

NASA Astrophysics Data System (ADS)

Häusler, K.; Hagan, M. E.; Baumgaertner, A. J. G.; Maute, A.; Lu, G.; Doornbos, E.; Bruinsma, S.; Forbes, J. M.; Gasperini, F.

2014-08-01

We report on a new source of tidal variability in the National Center for Atmospheric Research thermosphere-ionosphere-mesosphere-electrodynamics general circulation model (TIME-GCM). Lower boundary forcing of the TIME-GCM for a simulation of November-December 2009 based on 3-hourly Modern-Era Retrospective Analysis for Research and Application (MERRA) reanalysis data includes day-to-day variations in both diurnal and semidiurnal tides of tropospheric origin. Comparison with TIME-GCM results from a heretofore standard simulation that includes climatological tropospheric tides from the global-scale wave model reveal evidence of the impacts of MERRA forcing throughout the model domain, including measurable tidal variability in the TIME-GCM upper thermosphere. Additional comparisons with measurements made by the Gravity field and steady-state Ocean Circulation Explorer satellite show improved TIME-GCM capability to capture day-to-day variations in thermospheric density for the November-December 2009 period with the new MERRA lower boundary forcing.

Which metric of ambient ozone to predict daily mortality?

NASA Astrophysics Data System (ADS)

Moshammer, Hanns; Hutter, Hans-Peter; Kundi, Michael

2013-02-01

It is well known that ozone concentration is associated with daily cause specific mortality. But which ozone metric is the best predictor of the daily variability in mortality? We performed a time series analysis on daily deaths (all causes, respiratory and cardiovascular causes as well as death in elderly 65+) in Vienna for the years 1991-2009. We controlled for seasonal and long term trend, day of the week, temperature and humidity using the same basic model for all pollutant metrics. We found model fit was best for same day variability of ozone concentration (calculated as the difference between daily hourly maximum and minimum) and hourly maximum. Of these the variability displayed a more linear dose-response function. Maximum 8 h moving average and daily mean value performed not so well. Nitrogen dioxide (daily mean) in comparison performed better when previous day values were assessed. Same day ozone and previous day nitrogen dioxide effect estimates did not confound each other. Variability in daily ozone levels or peak ozone levels seem to be a better proxy of a complex reactive secondary pollutant mixture than daily average ozone levels in the Middle European setting. If this finding is confirmed this would have implications for the setting of legally binding limit values.

Processes of 30-90 days sea surface temperature variability in the northern Indian Ocean during boreal summer

NASA Astrophysics Data System (ADS)

Vialard, J.; Jayakumar, A.; Gnanaseelan, C.; Lengaigne, M.; Sengupta, D.; Goswami, B. N.

2012-05-01

During summer, the northern Indian Ocean exhibits significant atmospheric intraseasonal variability associated with active and break phases of the monsoon in the 30-90 days band. In this paper, we investigate mechanisms of the Sea Surface Temperature (SST) signature of this atmospheric variability, using a combination of observational datasets and Ocean General Circulation Model sensitivity experiments. In addition to the previously-reported intraseasonal SST signature in the Bay of Bengal, observations show clear SST signals in the Arabian Sea related to the active/break cycle of the monsoon. As the atmospheric intraseasonal oscillation moves northward, SST variations appear first at the southern tip of India (day 0), then in the Somali upwelling region (day 10), northern Bay of Bengal (day 19) and finally in the Oman upwelling region (day 23). The Bay of Bengal and Oman signals are most clearly associated with the monsoon active/break index, whereas the relationship with signals near Somali upwelling and the southern tip of India is weaker. In agreement with previous studies, we find that heat flux variations drive most of the intraseasonal SST variability in the Bay of Bengal, both in our model (regression coefficient, 0.9, against ~0.25 for wind stress) and in observations (0.8 regression coefficient); ~60% of the heat flux variation is due do shortwave radiation and ~40% due to latent heat flux. On the other hand, both observations and model results indicate a prominent role of dynamical oceanic processes in the Arabian Sea. Wind-stress variations force about 70-100% of SST intraseasonal variations in the Arabian Sea, through modulation of oceanic processes (entrainment, mixing, Ekman pumping, lateral advection). Our ~100 km resolution model suggests that internal oceanic variability (i.e. eddies) contributes substantially to intraseasonal variability at small-scale in the Somali upwelling region, but does not contribute to large-scale intraseasonal SST variability due to its small spatial scale and random phase relation to the active-break monsoon cycle. The effect of oceanic eddies; however, remains to be explored at a higher spatial resolution.

Does Absenteeism Differ for Children with Disabilities in Full-Day versus Part-Day Kindergarten?

ERIC Educational Resources Information Center

Gottfried, Michael A.

2017-01-01

Little is known about the effects of attending full-day versus part-day kindergarten for children with disabilities, and nothing is known about how these settings link to differences in children's school absences. This is concerning, given that children with disabilities have higher absence rates compared to children in the general population. To…

Longitudinal analysis of quality of life, clinical, radiographic, echocardiographic, and laboratory variables in dogs with myxomatous mitral valve disease receiving pimobendan or benazepril: the QUEST study.

PubMed

Häggström, J; Boswood, A; O'Grady, M; Jöns, O; Smith, S; Swift, S; Borgarelli, M; Gavaghan, B; Kresken, J-G; Patteson, M; Åblad, B; Bussadori, C M; Glaus, T; Kovačević, A; Rapp, M; Santilli, R A; Tidholm, A; Eriksson, A; Belanger, M C; Deinert, M; Little, C J L; Kvart, C; French, A; Rønn-Landbo, M; Wess, G; Eggertsdottir, A; Lynne O'Sullivan, M; Schneider, M; Lombard, C W; Dukes-McEwan, J; Willis, R; Louvet, A; DiFruscia, R

2013-01-01

Myxomatous mitral valve disease (MMVD) is an important cause of morbidity and mortality in dogs. To compare, throughout the period of follow-up of dogs that had not yet reached the primary endpoint, the longitudinal effects of pimobendan versus benazepril hydrochloride treatment on quality-of-life (QoL) variables, concomitant congestive heart failure (CHF) treatment, and other outcome variables in dogs suffering from CHF secondary to MMVD. A total of 260 dogs in CHF because of MMVD. A prospective single-blinded study with dogs randomized to receive pimobendan (0.4-0.6 mg/kg/day) or benazepril hydrochloride (0.25-1.0 mg/kg/day). Differences in outcome variables and time to intensification of CHF treatment were compared. A total of 124 dogs were randomized to pimobendan and 128 to benazepril. No difference was found between groups in QoL variables during the trial. Time from inclusion to 1st intensification of CHF treatment was longer in the pimobendan group (pimobendan 98 days, IQR 30-276 days versus benazepril 59 days, IQR 11-121 days; P = .0005). Postinclusion, dogs in the pimobendan group had smaller heart size based on VHS score (P = .013) and left ventricular diastolic (P = .035) and systolic (P = .0044) dimensions, higher body temperature (P = .030), serum sodium (P = .0027), and total protein (P = .0003) concentrations, and packed cell volume (P = .030). Incidence of arrhythmias was similar in treatment groups. Pimobendan versus benazepril resulted in similar QoL during the study, but conferred increased time before intensification of CHF treatment. Pimobendan treatment resulted in smaller heart size, higher body temperature, and less retention of free water. Copyright © 2013 by the American College of Veterinary Internal Medicine.

Variability of Organophosphorous Pesticide Metabolite Levels in Spot and 24-hr Urine Samples Collected from Young Children during 1 Week

PubMed Central

Kogut, Katherine; Eisen, Ellen A.; Jewell, Nicholas P.; Quirós-Alcalá, Lesliam; Castorina, Rosemary; Chevrier, Jonathan; Holland, Nina T.; Barr, Dana Boyd; Kavanagh-Baird, Geri; Eskenazi, Brenda

2012-01-01

Background: Dialkyl phosphate (DAP) metabolites in spot urine samples are frequently used to characterize children’s exposures to organophosphorous (OP) pesticides. However, variable exposure and short biological half-lives of OP pesticides could result in highly variable measurements, leading to exposure misclassification. Objective: We examined within- and between-child variability in DAP metabolites in urine samples collected during 1 week. Methods: We collected spot urine samples over 7 consecutive days from 25 children (3–6 years of age). On two of the days, we collected 24-hr voids. We assessed the reproducibility of urinary DAP metabolite concentrations and evaluated the sensitivity and specificity of spot urine samples as predictors of high (top 20%) or elevated (top 40%) weekly average DAP metabolite concentrations. Results: Within-child variance exceeded between-child variance by a factor of two to eight, depending on metabolite grouping. Although total DAP concentrations in single spot urine samples were moderately to strongly associated with concentrations in same-day 24-hr samples (r ≈ 0.6–0.8, p < 0.01), concentrations in spot samples collected > 1 day apart and in 24-hr samples collected 3 days apart were weakly correlated (r ≈ –0.21 to 0.38). Single spot samples predicted high (top 20%) and elevated (top 40%) full-week average total DAP excretion with only moderate sensitivity (≈ 0.52 and ≈ 0.67, respectively) but relatively high specificity (≈ 0.88 and ≈ 0.78, respectively). Conclusions: The high variability we observed in children’s DAP metabolite concentrations suggests that single-day urine samples provide only a brief snapshot of exposure. Sensitivity analyses suggest that classification of cumulative OP exposure based on spot samples is prone to type 2 classification errors. PMID:23052012

The Tölz Temporal Topography Study: mapping the visual field across the life span. Part II: cognitive factors shaping visual field maps.

PubMed

Poggel, Dorothe A; Treutwein, Bernhard; Calmanti, Claudia; Strasburger, Hans

2012-08-01

Part I described the topography of visual performance over the life span. Performance decline was explained only partly by deterioration of the optical apparatus. Part II therefore examines the influence of higher visual and cognitive functions. Visual field maps for 95 healthy observers of static perimetry, double-pulse resolution (DPR), reaction times, and contrast thresholds, were correlated with measures of visual attention (alertness, divided attention, spatial cueing), visual search, and the size of the attention focus. Correlations with the attentional variables were substantial, particularly for variables of temporal processing. DPR thresholds depended on the size of the attention focus. The extraction of cognitive variables from the correlations between topographical variables and participant age substantially reduced those correlations. There is a systematic top-down influence on the aging of visual functions, particularly of temporal variables, that largely explains performance decline and the change of the topography over the life span.

Insights into thermal stress in Japanese quail (Coturnix coturnix): dynamics of immunoendocrine and biochemical responses during and after chronic exposure.

PubMed

Nazar, Franco Nicolas; Videla, Emiliano Ariel; Fernandez, Maria Emilia; Labaque, Maria Carla; Marin, Raul Hector

2018-05-01

Avian require comfortable temperatures for optimal development and heat stress is a high concern in warm weather countries. We aimed to assess the dynamics of immunoendocrine and biochemical variables responses of birds exposed to a heat stressor applied during daylight hours, during the chronic stress and the recovery periods. We hypothesize that variables involved in the birds response will be differentially and gradually modified during those periods. Female quail (n = 210) were housed in six rearing boxes. At 29 days of age, the temperature in three boxes was increased from 24 to 34 °C during the light period throughout the nine days (Stress Treatment). The other three boxes remained at 24 °C and were used as controls. The subsequent 12 days were considered as recovery period. Different sets of 12 birds/treatment were blood-sampled at 29 (basal), 32, 35, 38 (stress), 41, 44, 47, and 50 (recovery) days of age, respectively. Immunoendocrine (corticosterone, lymphoproliferation, heterophil/lymphocyte ratio (H/L), and antibody response) and biochemical (glucose, total proteins, globulins, and albumin) variables were assessed. During stress, progressive corticosterone and H/L increments, and antibody titers and lymphoproliferation decreases were detected. No clear pattern of changes was found in biochemical variables. During recovery, while corticosterone and lymphoproliferation had recovered three days after the stressor ended, H/L and antibody responses required respectively nine and 12 days to recover to their basal levels, respectively. Findings suggest that immunity is already threatened when heat stress is sustained for three or more days. However, the system appears resilient, needing six to 12 days to recover to their basal responses.

Which sexual abuse victims receive a forensic medical examination? The impact of Children's Advocacy Centers.

PubMed

Walsh, Wendy A; Cross, Theodore P; Jones, Lisa M; Simone, Monique; Kolko, David J

2007-10-01

This study examines the impact of Children's Advocacy Centers (CAC) and other factors, such as the child's age, alleged penetration, and injury on the use of forensic medical examinations as part of the response to reported child sexual abuse. This analysis is part of a quasi-experimental study, the Multi-Site Evaluation of Children's Advocacy Centers, which evaluated four CACs relative to within-state non-CAC comparison communities. Case abstractors collected data on forensic medical exams in 1,220 child sexual abuse cases through review of case records. Suspected sexual abuse victims at CACs were two times more likely to have forensic medical examinations than those seen at comparison communities, controlling for other variables. Girls, children with reported penetration, victims who were physically injured while being abused, White victims, and younger children were more likely to have exams, controlling for other variables. Non-penetration cases at CACs were four times more likely to receive exams as compared to those in comparison communities. About half of exams were conducted the same day as the reported abuse in both CAC and comparison communities. The majority of caregivers were very satisfied with the medical professional. Receipt of a medical exam was not associated with offenders being charged. Results of this study suggest that CACs are an effective tool for furthering access to forensic medical examinations for child sexual abuse victims.

What do correlations tell us about anthropogenic-biogenic interactions and SOA formation in the Sacramento plume during CARES?

NASA Astrophysics Data System (ADS)

Kleinman, L.; Kuang, C.; Sedlacek, A.; Senum, G.; Springston, S.; Wang, J.; Zhang, Q.; Jayne, J.; Fast, J.; Hubbe, J.; Shilling, J.; Zaveri, R.

2016-02-01

During the Carbonaceous Aerosols and Radiative Effects Study (CARES) the US Department of Energy (DOE) G-1 aircraft was used to sample aerosol and gas phase compounds in the Sacramento, CA, plume and surrounding region. We present data from 66 plume transects obtained during 13 flights in which southwesterly winds transported the plume towards the foothills of the Sierra Nevada. Plume transport occurred partly over land with high isoprene emission rates. Our objective is to empirically determine whether organic aerosol (OA) can be attributed to anthropogenic or biogenic sources, and to determine whether there is a synergistic effect whereby OA concentrations are enhanced by the simultaneous presence of high concentrations of carbon monoxide (CO) and either isoprene, MVK + MACR (sum of methyl vinyl ketone and methacrolein), or methanol, which are taken as tracers of anthropogenic and biogenic emissions, respectively. Linear and bilinear correlations between OA, CO, and each of three biogenic tracers, "Bio", for individual plume transects indicate that most of the variance in OA over short timescales and distance scales can be explained by CO. For each transect and species a plume perturbation, (i.e., ΔOA, defined as the difference between 90th and 10th percentiles) was defined and regressions done amongst Δ values in order to probe day-to-day and location-dependent variability. Species that predicted the largest fraction of the variance in ΔOA were ΔO3 and ΔCO. Background OA was highly correlated with background methanol and poorly correlated with other tracers. Because background OA was ˜ 60 % of peak OA in the urban plume, peak OA should be primarily biogenic and therefore non-fossil, even though the day-to-day and spatial variability of plume OA is best described by an anthropogenic tracer, CO. Transects were split into subsets according to the percentile rankings of ΔCO and ΔBio, similar to an approach used by Setyan et al. (2012) and Shilling et al. (2013) to determine if anthropogenic-biogenic (A-B) interactions enhance OA production. As found earlier, ΔOA in the data subset having high ΔCO and high ΔBio was several-fold greater than in other subsets. Part of this difference is consistent with a synergistic interaction between anthropogenic and biogenic precursors and part to an independent linear dependence of ΔOA on precursors. The highest values of ΔO3, along with high temperatures, clear skies, and poor ventilation, also occurred in the high ΔCO-high ΔBio data set. A complicated mix of A-B interactions can result. After taking into account linear effects as predicted from low concentration data, an A-B enhancement of OA by a factor of 1.2 to 1.5 is estimated.

Advancing Variable Star Astronomy: The Centennial History of the American Association of Variable Star Observers

NASA Astrophysics Data System (ADS)

Williams, Thomas R.; Saladyga, Michael

2011-05-01

Preface; Part I. Pioneers in Variable Star Astronomy Prior to 1909: 1. The emergence of variable star astronomy - a need for observations; 2. A need for observers; Part II. The Founding of the AAVSO - The William Tyler Olcott Era: 3. The amateur's amateur; 4. Amateurs in the service of science; Part III. The Leon Campbell Era: 5. Leon Campbell to the rescue; 6. Formalizing relationships; 7. The Pickering Memorial Endowment; 8. Fading of the Old Guard; 9. Growing pains and distractions; Part IV. The Service Bureau - The Margaret Mayall Era: 10. Learning about independence; 11. Eviction from Harvard College Observatory; 12. Actions and reactions; 13. In search of a home; 14. Survival on Brattle Street; 15. AAVSO achievements; 16. Breathing room on Concord Avenue; Part V. Analysis and Science: The Janet Mattei Era: 17. The growth of a director; 18. Learning the ropes the hard way; 19. Managing with renewed confidence; 20. Expanding the scientific charter; Part VI. Accelerating Observational Science - The Arne Henden Era: 21. Bridging the gap; 22. Accelerating the science - the Henden era begins; Epilogue; Appendices; Index.

Reproduction of bobwhites fed different dietary concentrations of an organophosphate insecticide, methamidophos

USGS Publications Warehouse

Stromborg, K.L.

1986-01-01

Pairs of first-year breeding bobwhites were fed constant or variable concentrations of methamidophos for 15 days, or a control diet in a pair-fed design in which they were matched by body weights to pairs in the constant group. Treatments for the constant group were 5.0, 7.8, 12.3, 19.2, and 30.0 ppm for 5 pairs at each concentration. The number of pairs per concentration and peak concentrations for the variable pairs were identical to the constant dosages. Concentrations for the variable group were increased by a factor of four during two 3-day periods in order to reach the peak concentrations on days 7?9 after which they were decreased by 18% every 3 days to correspond to an environmental half-time of 10.5 days. Food consumption, egg production, hatchability of eggs under artificial incubation, and survival of hatched chicks for 2 weeks were recorded for each pair during 15-day treatment and 21-day posttreatment periods. Mortality was high in the highest constant dosage (2/10) and the associated pair-fed groups (3/10). Food consumption and egg production rates were negatively dose-related during the treatment period in the constant and variable groups. The laying rate of pair-fed hens was reduced to the same extent as in the constant group. Reproductive inhibition was not permanent and pairs resumed laying after a dose-related recovery interval. No dose-related effects on hatchability or chick survival were detected. Furthermore, there was no evidence of a pesticide effect on reproduction in addition to that exerted through pesticide-induced anorexia.

The effect of television news items on intimate partner violence murders.

PubMed

Vives-Cases, C; Torrubiano-Domínguez, J; Alvarez-Dardet, C

2009-12-01

This study has been carried out in order to explore the effect of the growing appearance of IPV in television news items on deaths by this cause. Ecological study based on 340 deaths by intimate partner violence (IPV) and 3733 television news items covering this topic on Spanish television channels (2003 and 2007). Logistic regression analysis was carried out. Dependent variable: the difference between the number of IPV deaths in the 7 days following a news item broadcast and the number of IPV deaths in the 7 days before a media item. This outcome variable was conceptualised as a binary variable: increase vs. no increase. days with IPV news items-in general, concerning deaths, measures or other IPV crimes. Adjusted variables: day of the week, month, year and public holidays. A small copycat effect was observed in the IPV murder rate (RR = 1.32, CI(95%) = 1.07 - 1.62) for IPV-related news item days compared with days without such news. This effect continued when information about deaths was broadcast (RR = 1.28, CI(95%) = 1.01 - 1.62). News items concerning measures (RR = 0.90, CI(95%) = 0.82 - 0.98) or other IPV crimes (0.84, CI(95%) = 0.82 - 0.98) were related to a lower possibility of an increase in deaths compared with days with death-related news. Given the results observed in the case of IPV-related news, there is an evident need to develop a journalistic style guide in order to determine what type of information is recommended due to the potential positive or negative effects.

[Dialysis dose, nutrition and growth among pediatric patients on peritoneal dialysis].

PubMed

Cano, Francisco; Azócar, Marta; Marín, Verónica; Rodríguez, Eugenio; Delucchi, Angela; Ratner, Rinat; Cavada, Gabriel

2005-12-01

Stunting is common among pediatric patients on peritoneal dialysis. To establish the best profile for urea kinetic variables associated to growth in children on chronic peritoneal dialysis (PD). Twenty patients, aged 1 month to 14 years, 13 males, were followed for 6-12 months, with monthly measurements of weight/age and height/age Z score; plasma creatinine, BUN, protein and albumin and urine and dialysate urea nitrogen, creatinine, protein and albumin. Minimum total Kt/V was 2.1. Dialysis dose (Kt/V), Protein Equivalent of Urea Nitrogen Appearance (PNA), Protein Catabolic Rate (PCR) and Nitrogen Balance (NB) were calculated. To identify the variable(s) associated to growth, the Tree Classification Model (CART) Enterprise Miner 8.1 was applied. Mean total/residual Kt/V: 3.4+/-1.3/1.69+/-1.27; Daily Protein Intake (DPI) was 3.25+/-1.27 g/kg/day. nPNA, PCR and NB were 1.37+/-0.44, 0.84+/-0.33 and 1.86+/-1.25 g/kg/day, respectively. Mean height/age Z score was -2.3+/-1.19. Eleven patients showed a positive height/age delta Z (mean 0.55+/-0.38) and nine showed a negative growth (mean -0.50+/-0.42). The main variable explaining the positive growth was a Nitrogen Balance between 0.54 and 2.37 g/kg/day, mean 1.55+/-0.21 (p <0.001). The second associated variable to growth was a residual Kt/V between 0.43 and 4.6 (2.02+/-0.49) (p <0.05). Kt/V and nPNA showed a significant correlation, but no correlation could be found between Kt/V and NB. Nitrogen Balance was the main variable associated to growth in pediatric PD, with values between 0.53 to 2.38 g/kg/day. The second variable was a residual Kt/V between 0.43 and 4.6. Therapy should be reassessed with NB values less than 0.54 or above 2.37 g/kg/day.

The role of SST variability in the simulation of the MJO

NASA Astrophysics Data System (ADS)

Stan, Cristiana

2017-12-01

The sensitivity of the Madden-Julian Oscillation to high-frequency variability (period 1-5 days) of sea surface temperature (SST) is investigated using numerical experiments with the super-parameterized Community Climate System Model. The findings of this study emphasize the importance of air-sea interactions in the simulation of the MJO, and stress the necessity of an accurate representation of ocean variability on short time scales. Eliminating 1-5-day variability of surface boundary forcing reduces the intraseasonal variability (ISV) of the tropics during the boreal winter. The ISV spectrum becomes close to the red noise background spectrum. The variability of atmospheric circulation shifts to longer time scales. In the absence of high-frequency variability of SST the MJO power gets confined to wavenumbers 1-2 and the magnitude of westward power associated with Rossby waves increases. The MJO convective activity propagating eastward from the Indian Ocean does not cross the Maritime Continent, and convection in the western Pacific Ocean is locally generated. In the Indian Ocean convection tends to follow the meridional propagation of SST anomalies. The response of the MJO to 1-5-day variability in the SST is through the charging and discharging mechanisms contributing to the atmospheric column moist static energy before and after peak MJO convection. Horizontal advection and surface fluxes show the largest sensitivity to SST perturbations.

Modeling Zero-Inflated and Overdispersed Count Data: An Empirical Study of School Suspensions

ERIC Educational Resources Information Center

Desjardins, Christopher David

2016-01-01

The purpose of this article is to develop a statistical model that best explains variability in the number of school days suspended. Number of school days suspended is a count variable that may be zero-inflated and overdispersed relative to a Poisson model. Four models were examined: Poisson, negative binomial, Poisson hurdle, and negative…

Does Stress Result in You Exercising Less? Or Does Exercising Result in You Being Less Stressed? Or is it Both?

PubMed Central

Burg, Matthew M.; Schwartz, Joseph E.; Kronish, Ian M.; Diaz, Keith M.; Alcantara, Carmela; Duer-Hefele, Joan; Davidson, Karina W.

2017-01-01

Background Psychosocial stress contributes to heart disease in part by adversely affecting maintenance of health behaviors, while exercise can reduce stress. Assessing the bi-directional relationship between stress and exercise has been limited by lack of real-time data, and theoretical and statistical models. This lack may hinder efforts to promote exercise maintenance. Purpose We test the bi-directional relationship between stress and exercise using real-time data for the average person, and the variability – individual differences – in this relationship. Methods A single cohort randomized controlled experiment. Healthy young adults (n=79) who reported only intermittent exercise, completed 12 months of stress monitoring by ecological momentary assessment (at the beginning of, end of, and during the day), and continuous activity monitoring by Fitbit. A random coefficients linear mixed model was used to predict end-of-day stress from the occurrence/non-occurrence of exercise that day; a logistic mixed model was used to predict the occurrence/non-occurrence of exercise from ratings of anticipated stress. Separate regression analyses were also performed for each participant. Sensitivity analysis tested all models, restricted to the first 180 days of observation (prior to randomization). Results We found a significant average inverse (i.e., negative) effect of exercise on stress and of stress on exercise. There was significant between-person variability. Of N=69, exercise was associated with a stress reduction for 15, a stress increase for 2, and no change for the remainder. We also found that an increase in anticipated stress reported the previous night or that morning was associated with a significant 20–22% decrease (OR=0.78–0.80) in the odds of exercising that day. Of N=69, this increase in stress reduced the likelihood of exercise for 17, increased the odds for 1, and had no effect for the remainder. We were unable to identify psychosocial factors that moderate the individual differences in these effects. Conclusions The relationship of stress to exercise can be uni- or bi-directional, and varies from person to person. A precision medicine approach may improve exercise uptake. PMID:28290065

Snow in Castile-León: trends and variability

NASA Astrophysics Data System (ADS)

Merino, A.; Campos, L.; López, L.; García-Ortega, E.; Sánchez, J. L.; Marcos, J. L.; Guerrero-Higueras, A. M.

2012-04-01

The location of Castile and León, inside the Iberian Peninsula, in the Northwestern quadrant, determines, in large measure, the climatic conditions of its territory, granting it very characteristic traits, mostly in the mountainous areas. It is important to note that during a large part of the year, the region is under the influence of Jet Stream, and thus, gives way to very diverse dynamic situations, which turn into different and heterogeneous types of weather. So, in many areas of the region, especially in the most elevated areas, these synoptic and mesoscale situations generate snow precipitation. We should point out that snowfall is one of the principal meteorological risks of Castile and León. Thus, on average, in some mountainous areas there are more than 40 events of snowfall registered annually, with the month of January being the month in which the highest frequency of snowfall appears. The social repercussions of this snowfall are represented in the isolation of places, essentially mountainous, highways being blocked, increase in traffic accidents, etc. As proof of this, it is this type of episode that receives ample coverage by the media, which has a linear relationship with the social perception of risk. As such, the objective of the current work is to analyze the annual trend of days with snow in the different meteorological stations pertaining to AEMET placed in the Community. The period of study is from 1960-2010. Additionally, we have also evaluated trends in annual days of freezing temperature and annual absolute minimum temperature, with the objective of facilitating a meteorological interpretation of the trends obtained on days with snowfall. Finally, the results show that in the majority of stations, a significant negative trend in days with snowfall and annual days with freezing temperatures, and a positive trend in annual absolute minimum temperatures. However, we observed variability in the different regions in the area of study. Acknowledgements The authors would like to thank the Regional Government of Castile-León for its financial support through the project LE220A11-2. This study was supported by the following grants: CEN20091028; GRANIMETRO (CGL2010-15930); MICROMETEO (IPT-310000-2010-22 ).

The association between weather conditions and stroke admissions in Turkey

NASA Astrophysics Data System (ADS)

Çevik, Yunsur; Doğan, Nurettin Özgür; Daş, Murat; Ahmedali, Asliddin; Kul, Seval; Bayram, Hasan

2015-07-01

Although several factors such as cigarette smoking, blood pressure, diabetes, obesity, hypercholesterolemia, physical inactivity and dietary factors have been well documented to increase the risk for stroke, there are conflicting data about the role of meteorological variables in the etiology of stroke. We conducted a retrospective study to investigate the association between weather patterns, including daily temperature, humidity, wind speed, and air pressure, and stroke admissions to the Emergency Department of Atatürk Training and Research Hospital in Ankara, Turkey, between January 2009 and April 2010. Generalized additive models with logistic link function were used to investigate the relationship between predictors and days with and without stroke admission at lags 0-4. A total of 373 stroke patients were admitted to the emergency department (ED) between January 2009 and April 2010. Of patients, 297 had ischemic stroke (IS), 34 hemorrhagic stroke (HS), and 42 subarachnoidal hemorrhage (SAH). Although we did not find any association between overall admissions due to stroke and meteorological parameters, univariable analysis indicated that there were significantly more SAH cases on days with lower daily mean temperatures of 8.79 ± 8.75 °C as compared to relatively mild days with higher temperatures (mean temperature = 11.89 ± 7.94 °C, p = 0.021). The multivariable analysis demonstrated that admissions due to SAH increased on days with lower daily mean temperatures for the same day (lag 0; odds ratio (OR) [95 % confidence interval (95 % CI)] = 0.93 [0.89-0.98], p = 0.004) and lag 1 (OR [95 % CI] =0.76 [0.67-0.86], p = 0.001). Furthermore, the wind speed at both lag 1 (OR [95 % CI] = 1.63 [1.27-2.09], p = 0.001) and lag 3 (OR [95 % CI] = 1.43 [1.12-1.81], p = 0.004) increased admissions due to HS, respectively. In conclusion, our study demonstrated that there was an association between ED admissions due to SAH and HS and weather conditions suggesting that meteorological variables may, at least in part, play as risk factors for intracranial hemorrhages.

STS-109 Mission Highlights Resource Tape. Part 4 of 4; Flight Days 8 - 12

NASA Technical Reports Server (NTRS)

2002-01-01

This video, Part 4 of 4, shows footage of crew activities from flight days 8 through 12 of STS-109. The crew included: Scott Altman, Commander; Duane Carey, Pilot; John Grunsfeld, Payload Commander; Nancy Currie, Richard Linnehan, James Newman, Michael Massimino, Mission Speicalists. The activities from other flights days can be seen on 'STS-109 Mission Highlights Resource Tape' Part 1 of 4 (internal ID 2002139471), 'STS-109 Mission Highlights Resource Tape' Part 2 of 4 (internal ID 2002137664), and 'STS-109 Mission Highlights Resource Tape' Part 3 of 4 (internal ID 2002139476). The primary activity on flight day 8 was an EVA (extravehicular activity) by Grunsfeld and Linnehan to install a cryocooler and radiator for the NICMOS (Near Infrared Camera and Multi-Object Spectrometer) on the HST (Hubble Space Telescope). Before returning to Columbia's airlock, the astronauts, with a cloudy background, hold onto the orbiter and offer their thoughts on the significance of their mission, the HST, and spaceflight. Footage from flight day 9 includes the grappling, unbearthing, and deployment of the HST from Columbia, and the crew coordinating and videotaping Columbia's departure. Flight day 10 was a relatively inactive day, and flight day 11 includes a checkout of Columbia's aerodynamic surfaces. Columbia landed on flight day 12, which is covered by footage of the crew members speaking during reentry, and their night landing, primarily shown through the orbiter's head-up display. The video includes numerous views of the HST, as well as views of the the Galapagos Islands, Madagascar, and Southern Africa with parts of the Atlantic, Indian, and Pacific Oceans, and part of the coast of Chile. The pistol grip space tool is shown in use, and the crew answers two messages from the public, including a message to Massimino from the Fire Department of New York.

The moderating role of personality traits in the relationship between work and salivary cortisol: a cross-sectional study of 401 employees in 34 Canadian companies.

PubMed

Parent-Lamarche, Annick; Marchand, Alain

2015-12-14

The objective of this study was to evaluate the contribution of personality traits in explaining the relationship between workplace stressors and variations in salivary cortisol concentrations. Multilevel regression analyses were performed on a sample of 401 employees from 34 Quebec firms. Saliva samples were collected five times a day (on awakening, 30 min after awakening, and at 2 p.m., 4 p.m., and bedtime). Sample collection was repeated on three days (1 rest day, 2 working days). Work-related variables comprised skill utilization, decision authority, psychological demands, physical demands, job insecurity, irregular schedule, number of working hours, and social support from coworkers and supervisors. Personality traits comprised self-esteem, locus of control, and the Big Five. Cortisol levels at awakening and 30 min later were significantly higher for work days than for days off. Psychological demands and job insecurity were associated with lower cortisol levels at bedtime. Also, self-esteem moderated the relationship between physical demands and cortisol levels at awakening and 4 p.m. Agreeableness was associated with lower cortisol levels at awakening and at 2 p.m. and further moderated the relationship between number of hours worked and cortisol at 2 p.m. Neuroticism moderated the relationship between coworker support and cortisol at bedtime. Specific working conditions and certain personality traits are associated with variations in salivary cortisol concentrations. In addition, certain personality traits moderate the relationship between stressors and salivary cortisol concentrations. In conclusion, salivary cortisol concentrations at work seem to be modulated in part by personality traits.

Good days and bad days in dementia: a qualitative chart review of variable symptom expression.

PubMed

Rockwood, Kenneth; Fay, Sherri; Hamilton, Laura; Ross, Elyse; Moorhouse, Paige

2014-08-01

Despite its importance in the lived experience of dementia, symptom fluctuation has been little studied outside Lewy body dementia. We aimed to characterize symptom fluctuation in patients with Alzheimer's disease (AD) and mixed dementia. A qualitative analysis of health records that included notations on good days and bad days yielded 52 community-dwelling patients (women, n = 30; aged 39-91 years; mild dementia, n = 26, chiefly AD, n = 36). Good days/bad days were most often described as changes in the same core set of symptoms (e.g. less/more verbal repetition). In other cases, only good or only bad days were described (e.g., no bad days, better sense of humor on good days). Good days were typically associated with improved global cognition, function, interest, and initiation. Bad days were associated with frequent verbal repetition, poor memory, increased agitation and other disruptive behaviors. Clinically important variability in symptoms appears common in AD and mixed dementia. Even so, what makes a day "good" is not simply more (or less) of what makes a day "bad". Further investigation of the factors that facilitate or encourage good days and mitigate bad days may help improve quality of life for patients and caregivers.

SHORT-TIMESCALE MONITORING OF THE X-RAY, UV, AND BROAD DOUBLE-PEAK EMISSION LINE OF THE NUCLEUS OF NGC 1097

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schimoia, Jaderson S.; Storchi-Bergmann, Thaisa; Grupe, Dirk

2015-02-10

Recent studies have suggested that the short-timescale (≲ 7 days) variability of the broad (∼10,000 km s{sup –1}) double-peaked Hα profile of the LINER nucleus of NGC 1097 could be driven by a variable X-ray emission from a central radiatively inefficient accretion flow. To test this scenario, we have monitored the NGC 1097 nucleus in X-ray and UV continuum with Swift and the Hα flux and profile in the optical spectrum using SOAR and Gemini-South from 2012 August to 2013 February. During the monitoring campaign, the Hα flux remained at a very low level—three times lower than the maximum flux observed in previousmore » campaigns and showing only limited (∼20%) variability. The X-ray variations were small, only ∼13% throughout the campaign, while the UV did not show significant variations. We concluded that the timescale of the Hα profile variation is close to the sampling interval of the optical observations, which results in only a marginal correlation between the X-ray and Hα fluxes. We have caught the active galaxy nucleus in NGC 1097 in a very low activity state, in which the ionizing source was very weak and capable of ionizing just the innermost part of the gas in the disk. Nonetheless, the data presented here still support the picture in which the gas that emits the broad double-peaked Balmer lines is illuminated/ionized by a source of high-energy photons which is located interior to the inner radius of the line-emitting part of the disk.« less

Congenital Hypothyroidism with Neurological and Respiratory Alterations: A Case Detected Using a Variable Diagnostic Threshold for TSH

PubMed Central

Barreiro, Jesús; Castro-Feijoo, Lidia; Colón, Cristóbal; Cabanas, Paloma; Heredia, Claudia; Castaño, Luis Antonio; Gómez-Lado, Carmen; Couce, M.Luz; Pombo, Manuel

2011-01-01

We report a case of congenital hypothyroidism (CH) with neurological and respiratory alterations due to a heterozygotic c.374-1G > A mutation of TITF1/NKX2-1. The hypothyroidism was detected using a neonatal screening protocol in which the thyroid stimulating hormone (TSH) threshold is re-set each day on the basis of within-day variability and between-day variation. In this case, the threshold on the day of the initial analysis was 8.2 mIU/L, and the measured TSH level in heel-prick blood was 8.3 mIU/L. Conflict of interest:None declared. PMID:22155464

Validation of the Episodic Disability Framework with adults living with HIV.

PubMed

O'Brien, Kelly K; Hanna, Steven; Gardner, Sandra; Bayoumi, Ahmed M; Rueda, Sergio; Hart, Trevor A; Cooper, Curtis; Solomon, Patricia; Rourke, Sean B; Davis, Aileen M

2014-01-01

To assess the validity of dimensions of disability in the Episodic Disability Framework, a conceptual framework derived from the perspective of adults living with HIV. We conducted confirmatory factor analyses with 913 adults living with HIV in an observational cohort study called the Ontario HIV Treatment Network Cohort Study (OCS). We tested hypotheses that dimensions of disability in the Episodic Disability Framework were represented by a group of measured variables in the observational database. A model comprised of four latent variables and 43 indicator variables with one cross-loading was superior to models with fewer latent variables and more indicator variables and supported the validity of disability dimensions: physical health symptoms (represented by 21 indicator variables), mental health symptoms (10 variables), difficulties with day-to-day activities (5 variables) and challenges to social inclusion (8 variables). Overall goodness of fit statistics were χ(2 )= 2621.50 (p < 0.001), Comparative Fit Index = 0.912, Tucker Lewis Index = 0.907 and root mean square error of approximation = 0.048. Dimensions of disability correlated with each other ranging from r = 0.44 (between physical symptoms and challenges to social inclusion) to r = 0.81 (between physical symptoms and difficulties with day-to-day activities). This study supports the validity of four disability dimensions in the Episodic Disability Framework. This framework provides a new way to conceptualize disability and can lay the foundation for developing a future HIV disability measure for clinical and health services research. The Episodic Disability Framework is the first known conceptual framework of disability developed from the perspective of adults living with HIV. Results from this confirmatory factor analysis support the validity of four dimensions of disability experienced by adults living with HIV in the Episodic Disability Framework including: physical symptoms and impairments, mental health symptoms and impairments, difficulties carrying out day-to-day activities, and challenges to social inclusion. The Episodic Disability Framework provides a new way to conceptualize disability experienced by adults living with HIV. Clinicians can use this Framework to better understand episodic disability experienced by adults living with HIV. Clinicians can frame their assessments of disability to include physical and mental health symptoms and impairments as well as consider a patient's ability to participate in society, and indicate areas to apply interventions or strategies to prevent or mitigate disability experienced by adults living with HIV.

Modeling Hydrodynamics and Heat Transport in Upper Klamath Lake, Oregon, and Implications for Water Quality

USGS Publications Warehouse

Wood, Tamara M.; Cheng, Ralph T.; Gartner, Jeffrey W.; Hoilman, Gene R.; Lindenberg, Mary K.; Wellman, Roy E.

2008-01-01

The three-dimensional numerical model UnTRIM was used to model hydrodynamics and heat transport in Upper Klamath Lake, Oregon, between mid-June and mid-September in 2005 and between mid-May and mid-October in 2006. Data from as many as six meteorological stations were used to generate a spatially interpolated wind field to use as a forcing function. Solar radiation, air temperature, and relative humidity data all were available at one or more sites. In general, because the available data for all inflows and outflows did not adequately close the water budget as calculated from lake elevation and stage-capacity information, a residual inflow or outflow was used to assure closure of the water budget. Data used for calibration in 2005 included lake elevation at 3 water-level gages around the lake, water currents at 5 Acoustic Doppler Current Profiler (ADCP) sites, and temperature at 16 water-quality monitoring locations. The calibrated model accurately simulated the fluctuations of the surface of the lake caused by daily wind patterns. The use of a spatially variable surface wind interpolated from two sites on the lake and four sites on the shoreline generally resulted in more accurate simulation of the currents than the use of a spatially invariant surface wind as observed at only one site on the lake. The simulation of currents was most accurate at the deepest site (ADCP1, where the velocities were highest) using a spatially variable surface wind; the mean error (ME) and root mean square error (RMSE) for the depth-averaged speed over a 37-day simulation from July 26 to August 31, 2005, were 0.50 centimeter per second (cm/s) and 3.08 cm/s, respectively. Simulated currents at the remaining sites were less accurate and, in general, underestimated the measured currents. The maximum errors in simulated currents were at a site near the southern end of the trench at the mouth of Howard Bay (ADCP7), where the ME and RMSE in the depth-averaged speed were 3.02 and 4.38 cm/s, respectively. The range in ME of the temperature simulations over the same period was ?0.94 to 0.73 degrees Celsius (?C), and the RMSE ranged from 0.43 to 1.12?C. The model adequately simulated periods of stratification in the deep trench when complete mixing did not occur for several days at a time. The model was validated using boundary conditions and forcing functions from 2006 without changing any calibration parameters. A spatially variable wind was used. Data for the model validation periods in 2006 included lake elevation at 4 gages around the lake, currents collected at 2 ADCP sites, and temperature collected at 21 water-quality monitoring locations. Errors generally were larger than in 2005. ME and RMSE in the simulated velocity at ADCP1 were 2.30 cm/s and 3.88 cm/s, respectively, for the same 37-day simulation over which errors were computed for 2005. The ME in temperature over the same period ranged from ?0.56 to 1.5?C and the RMSE ranged from 0.41 to 1.86?C. Numerical experiments with conservative tracers were used to demonstrate the prevailing clockwise circulation patterns in the lake, and to show the influence of water from the deep trench located along the western shoreline of the lake on fish habitat in the northern part of the lake. Because water exiting the trench is split into two pathways, the numerical experiments indicate that bottom water from the trench has a stronger influence on water quality in the northern part of the lake, and surface water from the trench has a stronger influence on the southern part of the lake. This may be part of the explanation for why episodes of low dissolved oxygen tend to be more severe in the northern than in the southern part of the lake.

Variability in muscle dysmorphia symptoms: the influence of weight training.

PubMed

Thomas, Liam S; Tod, David A; Lavallee, David E

2011-03-01

The purpose of this study was to examine the influence of a weight training session on muscle dysmorphia symptoms in young men who regularly weight trained. Using a within-subjects crossover design, 30 men (mean ± SD; 20.93 ± 2.60 years, 86.87 ± 10.59 kg, and 1.76 ± 0.01 m) were randomly allocated to 1 of 2 groups, and completed the Muscle Dysmorphic Disorder Inventory twice, once each on 2 separate days. One day 1, group 1 completed the questionnaire after a weight training session and group 2 on a rest day. One day 2, group 1 completed the questionnaire on a rest day and group 2 after a weight training session. The mean score for drive for size was significantly higher on a rest day (18.00) than on a training day (15.87; p = 0.001, d = 1.03). The mean score for appearance intolerance was significantly higher on a rest day (10.10) compared with that on a training day (8.97; p = 0.001, d = 0.69). The mean score for functional impairment was significantly higher on a rest day (10.20) than on a training day (9.47; p = 0.037, d = 0.40). These results provide evidence that muscle dysmorphia symptoms have state-like properties and may be influenced by situational variables. The results may indicate that strength and conditioning specialists and mental health professionals need to observe clients over time and take into account environmental variables before making decisions about the presence or absence of the condition.

Climatic change effects on hydro-metereological variables in the Alps: a case study on the upper Arve catchment at Chamonix (France) over the last 50 years

NASA Astrophysics Data System (ADS)

Viani, Alessandra; Condom, Thomas; Bacchi, Baldassare; Zin, Isabella; Six, Delphine; Gottardi, Frederic; Rabatel, Antoine; Morin, Samuel

2016-04-01

Hydrological changes in partially glaciated catchments are expected under future climate scenarios, with consequences for water availability and management at catchment and regional scales. In order to correctly predict the magnitude of such changes and envisage adaptation and/or mitigation measures against water related hazards, a good understanding of the water cycle dynamics at different spatial and temporal scales is needed. The Upper Arve catchment in Chamonix (202 square kilometers), situated in the French Northern Alps, between the two massifs of Mont Blanc and Aiguilles Rouges, is a perfect case study for evaluating the sensitivity of the alpine water cycle to climate change. It is highly glaciated (32% of the total area in 2012) with three important glaciers: Glacier du Tour, Glacier d'Argentiere and Glacier de la Mer de Glace. Its elevation ranges from 1025 up to 4295 m a.s.l. and the exposure of the ice cover is generally north and east oriented. Long term time-series exist of (i) glacier mass balance, (ii) meteorological (in-situ and reanalyses) and (iii) hydrological data. The objectives of the presented study were: 1 - To characterize the inter-annual regimes of the different climatological and hydrological variables: precipitation, temperature and discharge; 2 - To estimate trends on the previous variables, at different temporal scales (annual and monthly) for different altitudes, and compare them to usually observed values in alpine regions; 3 - To infer from the previous statistical analyses and from a cross-analysis between the different considered variables the catchment's hydrological evolution during the last 50 years. Results showed precipitation, temperature and discharge regimes typical of high mountainous partially glaciated catchments. In the long term period, this catchment is characterized by an evident retreat of glacier. Long term trends over the past five decades show no significant change in the annual amount of precipitation. At the same time, a significantly increase of the number of rainy or snowy days is observed, related to an increase of the number of days with small precipitation intensities. Particularly, we have estimated a significant positive trend in the number of liquid precipitation days with intensities less than 10 mm per day (+ 49 days/year from 1934 to 2014). On the other hand, temperature increases significantly of about 0.3 K per decade in average over the lower part of the catchment (between 1100 and 2100 m a.s.l.). This increase is slightly greater than the previous estimated trends over the French Alps. At the same time, a weaker trend is estimated at higher altitudes, from 3000 to 3600 m a.s.l., which is a more surprising result with respect to the previous published values. Finally, an hydrological regime shift is observed with a melting season occurring earlier for the last two decades.

Individual differences affecting caffeine intake. Analysis of consumption behaviours for different times of day and caffeine sources.

PubMed

Penolazzi, Barbara; Natale, Vincenzo; Leone, Luigi; Russo, Paolo Maria

2012-06-01

The main purpose of the present study was to investigate the individual variables contributing to determine the high variability in the consumption behaviours of caffeine, a psychoactive substance which is still poorly investigated in comparison with other drugs. The effects of a large set of specific personality traits (i.e., Impulsivity, Sensation Seeking, Anxiety, Reward Sensitivity and Circadian Preference) were compared along with some relevant socio-demographic variables (i.e., gender and age) and cigarette smoking behaviour. Analyses revealed that daily caffeine intake was significantly higher for males, older people, participants smoking more cigarettes and showing higher scores on Impulsivity, Sensation Seeking and a facet of Reward Sensitivity. However, more detailed analyses showed that different patterns of individual variables predicted caffeine consumption when the times of day and the caffeine sources were considered. The present results suggest that such detailed analyses are required to detect the critical predictive variables that could be obscured when only total caffeine intake during the entire day is considered. Copyright © 2012 Elsevier Ltd. All rights reserved.

Exploring the meteorological potential for planning a high performance European electricity super-grid: optimal power capacity distribution among countries

NASA Astrophysics Data System (ADS)

Santos-Alamillos, Francisco J.; Brayshaw, David J.; Methven, John; Thomaidis, Nikolaos S.; Ruiz-Arias, José A.; Pozo-Vázquez, David

2017-11-01

The concept of a European super-grid for electricity presents clear advantages for a reliable and affordable renewable power production (photovoltaics and wind). Based on the mean-variance portfolio optimization analysis, we explore optimal scenarios for the allocation of new renewable capacity at national level in order to provide to energy decision-makers guidance about which regions should be mostly targeted to either maximize total production or reduce its day-to-day variability. The results show that the existing distribution of renewable generation capacity across Europe is far from optimal: i.e. a ‘better’ spatial distribution of resources could have been achieved with either a ~31% increase in mean power supply (for the same level of day-to-day variability) or a ~37.5% reduction in day-to-day variability (for the same level of mean productivity). Careful planning of additional increments in renewable capacity at the European level could, however, act to significantly ameliorate this deficiency. The choice of where to deploy resources depends, however, on the objective being pursued—if the goal is to maximize average output, then new capacity is best allocated in the countries with highest resources, whereas investment in additional capacity in a north/south dipole pattern across Europe would act to most reduce daily variations and thus decrease the day-to-day volatility of renewable power supply.

Positive association between sugar consumption and dental decay prevalence independent of oral hygiene in pre-school children: a longitudinal prospective study.

PubMed

Skafida, V; Chambers, S

2017-12-29

Few studies explore how the longitudinal cumulative and combined effects of dietary habits and oral hygiene habits relate to dental decay in very young children. Using longitudinal survey data, logistic regression models were specified to predict dental decay by age 5. Predictor variables included questions on diet and oral hygiene from ages 2 to 5. Compared to mainly eating meals, children who snacked all day but had no real meals had a higher chance of dental decay (odds ratios (OR) = 2.32). There was an incremental association between a decreasing frequency of toothbrushing at age 2 and higher chances of dental decay at age 5 (OR range from 1.39 to 2.17). Among children eating sweets or chocolate more frequently (once/day or more), toothbrushing more often (once/day; twice/day or more) reduced the chance of decay (OR of 2.11-2.26 compared to OR 3.60 for the least frequent brushing group). Compared to mothers in managerial and professional occupations, those who had never worked had children with a much higher chance of decay (OR = 3.47). This study has shown that toothbrushing can only in part attenuate the association between snacking and long term sugar consumption on dental decay outcomes in children under 5. © The Author(s) 2017. Published by Oxford University Press on behalf of Faculty of Public Health.

Using motion-sensor camera technology to infer seasonal activity and thermal niche of the desert tortoise (Gopherus agassizii).

PubMed

Agha, Mickey; Augustine, Benjamin; Lovich, Jeffrey E; Delaney, David; Sinervo, Barry; Murphy, Mason O; Ennen, Joshua R; Briggs, Jessica R; Cooper, Robert; Price, Steven J

2015-01-01

Understanding the relationships between environmental variables and wildlife activity is an important part of effective management. The desert tortoise (Gopherus agassizii), an imperiled species of arid environments in the southwest US, may have increasingly restricted windows for activity due to current warming trends. In summer 2013, we deployed 48 motion sensor cameras at the entrances of tortoise burrows to investigate the effects of temperature, sex, and day of the year on the activity of desert tortoises. Using generalized estimating equations, we found that the relative probability of activity was associated with temperature (linear and quadratic), sex, and day of the year. Sex effects showed that male tortoises are generally more active than female tortoises. Temperature had a quadratic effect, indicating that tortoise activity was heightened at a range of temperatures. In addition, we found significant support for interactions between sex and day of the year, and sex and temperature as predictors of the probability of activity. Using our models, we were able to estimate air temperatures and times (days and hours) that were associated with maximum activity during the study. Because tortoise activity is constrained by environmental conditions such as temperature, it is increasingly vital to conduct studies on how tortoises vary their activity throughout the Sonoran Desert to better understand the effects of a changing climate. Copyright © 2015 Elsevier Ltd. All rights reserved.

Using motion-sensor camera technology to infer seasonal activity and thermal niche of the desert tortoise (Gopherus agassizii)

USGS Publications Warehouse

Agha, Mickey; Augustine, Benjamin; Lovich, Jeffrey E.; Delaney, David F.; Sinervo, Barry; Murphy, Mason O.; Ennen, Joshua R.; Briggs, Jessica R.; Cooper, Robert J.; Price, Steven J.

2015-01-01

Understanding the relationships between environmental variables and wildlife activity is an important part of effective management. The desert tortoise (Gopherus agassizii), an imperiled species of arid environments in the southwest US, may have increasingly restricted windows for activity due to current warming trends. In summer 2013, we deployed 48 motion sensor cameras at the entrances of tortoise burrows to investigate the effects of temperature, sex, and day of the year on the activity of desert tortoises. Using generalized estimating equations, we found that the relative probability of activity was associated with temperature (linear and quadratic), sex, and day of the year. Sex effects showed that male tortoises are generally more active than female tortoises. Temperature had a quadratic effect, indicating that tortoise activity was heightened at a range of temperatures. In addition, we found significant support for interactions between sex and day of the year, and sex and temperature as predictors of the probability of activity. Using our models, we were able to estimate air temperatures and times (days and hours) that were associated with maximum activity during the study. Because tortoise activity is constrained by environmental conditions such as temperature, it is increasingly vital to conduct studies on how tortoises vary their activity throughout the Sonoran Desert to better understand the effects of a changing climate.

Observed changes in extreme precipitation in Poland: 1991-2015 versus 1961-1990

NASA Astrophysics Data System (ADS)

Pińskwar, Iwona; Choryński, Adam; Graczyk, Dariusz; Kundzewicz, Zbigniew W.

2018-01-01

Several episodes of extreme precipitation excess and extreme precipitation deficit, with considerable economic and social impacts, have occurred in Europe and in Poland in the last decades. However, the changes of related indices exhibit complex variability. This paper analyses changes in indices related to observed abundance and deficit of precipitated water in Poland. Among studied indices are maximum seasonal 24-h precipitation for the winter half-year (Oct.-March) and the summer half-year (Apr.-Sept.), maximum 5-day precipitation, maximum monthly precipitation and number of days with intense or very intense precipitation (respectively, in excess of 10 mm or 20 mm per day). Also, the warm-seasonal maximum number of consecutive dry days (longest period with daily precipitation below 1 mm) was examined. Analysis of precipitation extremes showed that daily maximum precipitation for the summer half-year increased for many stations, and increases during the summer half-year are more numerous than those in the winter half-year. Also, analysis of 5-day and monthly precipitation sums show increases for many stations. Number of days with intense precipitation increases especially in the north-western part of Poland. The number of consecutive dry days is getting higher for many stations in the summer half-year. Comparison of these two periods: colder 1961-1990 and warmer 1991-2015, revealed that during last 25 years most of statistical indices, such as 25th and 75th percentiles, median, mean and maximum are higher. However, many changes discussed in this paper are weak and statistically insignificant. The findings reported in this paper challenge results based on earlier data that do not include 2007-2015.

Two-Part and Related Regression Models for Longitudinal Data

PubMed Central

Farewell, V.T.; Long, D.L.; Tom, B.D.M.; Yiu, S.; Su, L.

2017-01-01

Statistical models that involve a two-part mixture distribution are applicable in a variety of situations. Frequently, the two parts are a model for the binary response variable and a model for the outcome variable that is conditioned on the binary response. Two common examples are zero-inflated or hurdle models for count data and two-part models for semicontinuous data. Recently, there has been particular interest in the use of these models for the analysis of repeated measures of an outcome variable over time. The aim of this review is to consider motivations for the use of such models in this context and to highlight the central issues that arise with their use. We examine two-part models for semicontinuous and zero-heavy count data, and we also consider models for count data with a two-part random effects distribution. PMID:28890906

Estimating Selected Streamflow Statistics Representative of 1930-2002 in West Virginia

USGS Publications Warehouse

Wiley, Jeffrey B.

2008-01-01

Regional equations and procedures were developed for estimating 1-, 3-, 7-, 14-, and 30-day 2-year; 1-, 3-, 7-, 14-, and 30-day 5-year; and 1-, 3-, 7-, 14-, and 30-day 10-year hydrologically based low-flow frequency values for unregulated streams in West Virginia. Regional equations and procedures also were developed for estimating the 1-day, 3-year and 4-day, 3-year biologically based low-flow frequency values; the U.S. Environmental Protection Agency harmonic-mean flows; and the 10-, 25-, 50-, 75-, and 90-percent flow-duration values. Regional equations were developed using ordinary least-squares regression using statistics from 117 U.S. Geological Survey continuous streamflow-gaging stations as dependent variables and basin characteristics as independent variables. Equations for three regions in West Virginia - North, South-Central, and Eastern Panhandle - were determined. Drainage area, precipitation, and longitude of the basin centroid are significant independent variables in one or more of the equations. Estimating procedures are presented for determining statistics at a gaging station, a partial-record station, and an ungaged location. Examples of some estimating procedures are presented.

A synoptic approach to weather conditions discloses a relationship with ambulatory blood pressure in hypertensives.

PubMed

Morabito, Marco; Crisci, Alfonso; Orlandini, Simone; Maracchi, Giampiero; Gensini, Gian F; Modesti, Pietro A

2008-07-01

Higher blood pressure (BP) values in cold than in hot months has been documented in hypertensives. These changes may potentially contribute to the observed excess winter cardiovascular mortality. However, the association with weather has always been investigated by considering the relationship with a single variable rather than considering the combination of ground weather variables characterizing a specific weather pattern (air mass (AM)). We retrospectively investigate in Florence (Italy) the relationship between BP and specific AMs in hypertensive subjects (n = 540) referred to our Hypertension Unit for 24-h ambulatory BP monitoring during the period of the year characterized by the highest weather variability (winter). Five different winter daily AMs were classified according to the combination of ground weather data (air temperature, cloud cover, relative humidity, atmospheric pressure, wind speed, and direction). Multiple variable analysis selected the AM as a significant predictor of mean 24-h BP (P < 0.01 for diastolic BP (DBP) and P < 0.05 for systolic BP (SBP)), daytime DBP (P < 0.001) and nighttime BP (P < 0.01 for both SBP and DBP), with higher BP values observed in cyclonic (unstable, cloudy, and mild weather) than in anticyclonic (settled, cloudless, and cold weather) days. When the association with 2-day sequences of AMs was considered, an increase in ambulatory BP followed a sudden day-to-day change of weather pattern going from anticyclonic to cyclonic days. The weather considered as a combination of different weather variables may affect BP. The forecast of a sudden change of AM could provide important information helpful for hypertensives during winter.

Composition of the lower crust of the Arabian Plate: a xenolith perspective

NASA Astrophysics Data System (ADS)

Al-Mishwat, Ali T.; Nasir, Sobhi J.

2004-01-01

Petrological and geochemical data for a suite of mafic granulite xenoliths in Cenozoic alkali basalts from Saudi Arabia, Jordan and Syria provide a unique opportunity to explore the composition and nature of the lower crust beneath the Arabian Plate. Two mineralogically and chemically distinct groups of xenoliths occur. Group I is composed of two pyroxenes and plagioclase approximately in equal amounts. Group II is plagioclase rich and has variable proportions of orthopyroxene and clinopyroxene. The xenolith mineral assemblages and geothermobarometry of coexisting minerals suggest that these xenoliths represent basaltic cumulates that crystallized under high-pressure conditions in the lower crust. The xenoliths possibly form a part of a lower crustal gabbroic intrusive complex that underlies the Arabian Plate and may represent mafic roots of an arc complex of Pan-African age beneath Arabia. The xenolith data are compatible with available geophysical models on crust thickness and layering. The crust is between 20 and 40 km thick, and its lower part consists of mafic meta-igneous granulites. The chemical averages of xenoliths from different parts of the Arabian Plate are more mafic than the estimated present-day average of model lower crust.

Does price efficiency increase with trading volume? Evidence of nonlinearity and power laws in ETFs

NASA Astrophysics Data System (ADS)

Caginalp, Gunduz; DeSantis, Mark

2017-02-01

Whether efficiency increases with increasing volume is an important issue that may illuminate trader strategies and distinguish between market theories. This relationship is tested using 124,236 daily observations comprising 68 large and liquid U.S. equity exchange traded funds (ETFs). ETFs have the advantage that efficiency can be measured in terms of the deviation between the trading price and the underlying net asset value that is reported each day. Our findings support the hypothesis that the relationship between volume and efficiency is nonlinear. Indeed, efficiency increases as volume increases from low to moderately high levels, but then decreases as volume increases further. The first part tends to support the idea that higher volume simply facilitates transactions and maintains efficiency, while the latter part, i.e., even higher volumes, supports the ansatz that increased volume is associated with increased speculation that ignores valuation and decreases efficiency. The results are consistent with the hypothesis that valuation is only part of the motivation for traders. Our methodology accounts for fund heterogeneity and contemporaneous correlations. Similar results are obtained when daily price volatility is introduced as an additional independent variable.

The Variability of Crater Identification Among Expert and Community Crater Analysts

NASA Astrophysics Data System (ADS)

Robbins, S. J.; Antonenko, I.; Kirchoff, M. R.; Chapman, C. R.; Fassett, C. I.; Herrick, R. R.; Singer, K.; Zanetti, M.; Lehan, C.; Huang, D.; Gay, P.

2014-04-01

Statistical studies of impact crater populations have been used to model ages of planetary surfaces for several decades [1]. This assumes that crater counts are approximately invariant and a "correct" population will be identified if the analyst is skilled and diligent. However, the reality is that crater identification is somewhat subjective, so variability between analysts, or even a single analyst's variation from day-to-day, is expected [e.g., 2, 3]. This study was undertaken to quantify that variability within an expert analyst population and between experts and minimally trained volunteers.

Variability in Classroom Social Communication: Performance of Children with Fetal Alcohol Spectrum Disorders and Typically Developing Peers

ERIC Educational Resources Information Center

Kjellmer, Liselotte; Olswang, Lesley B.

2013-01-01

Purpose: In this study, the authors examined how variability in classroom social communication performance differed between children with fetal alcohol spectrum disorders (FASD) and pair-matched, typically developing peers. Method: Twelve pairs of children were observed in their classrooms, 40 min per day (20 min per child) for 4 days over a…

Evaluation of cardiac surgery mortality rates: 30-day mortality or longer follow-up?

PubMed

Siregar, Sabrina; Groenwold, Rolf H H; de Mol, Bas A J M; Speekenbrink, Ron G H; Versteegh, Michel I M; Brandon Bravo Bruinsma, George J; Bots, Michiel L; van der Graaf, Yolanda; van Herwerden, Lex A

2013-11-01

The aim of our study was to investigate early mortality after cardiac surgery and to determine the most adequate follow-up period for the evaluation of mortality rates. Information on all adult cardiac surgery procedures in 10 of 16 cardiothoracic centres in Netherlands from 2007 until 2010 was extracted from the database of Netherlands Association for Cardio-Thoracic Surgery (n = 33 094). Survival up to 1 year after surgery was obtained from the national death registry. Survival analysis was performed using Kaplan-Meier and Cox regression analysis. Benchmarking was performed using logistic regression with mortality rates at different time points as dependent variables, the logistic EuroSCORE as covariate and a random intercept per centre. In-hospital mortality was 2.94% (n = 972), 30-day mortality 3.02% (n = 998), operative mortality 3.57% (n = 1181), 60-day mortality 3.84% (n = 1271), 6-month mortality 5.16% (n = 1707) and 1-year mortality 6.20% (n = 2052). The survival curves showed a steep initial decline followed by stabilization after ∼60-120 days, depending on the intervention performed, e.g. 60 days for isolated coronary artery bypass grafting (CABG) and 120 days for combined CABG and valve surgery. Benchmark results were affected by the choice of the follow-up period: four hospitals changed outlier status when the follow-up was increased from 30 days to 1 year. In the isolated CABG subgroup, benchmark results were unaffected: no outliers were found using either 30-day or 1-year follow-up. The course of early mortality after cardiac surgery differs across interventions and continues up to ∼120 days. Thirty-day mortality reflects only a part of early mortality after cardiac surgery and should only be used for benchmarking of isolated CABG procedures. The follow-up should be prolonged to capture early mortality of all types of interventions.

Enhanced future variability during India's rainy season

NASA Astrophysics Data System (ADS)

Menon, Arathy; Levermann, Anders; Schewe, Jacob

2013-06-01

The Indian summer monsoon shapes the livelihood of a large share of the world's population. About 80% of annual precipitation over India occurs during the monsoon season from June through September. Next to its seasonal mean rainfall, the day-to-day variability is crucial for the risk of flooding, national water supply, and agricultural productivity. Here we show that the latest ensemble of climate model simulations, prepared for the AR-5 of the Intergovernmental Panel on Climate Change, consistently projects significant increases in day-to-day rainfall variability under unmitigated climate change. The relative increase by the period 2071-2100 with respect to the control period 1871-1900 ranges from 13% to 50% under the strongest scenario (Representative Concentration Pathways, RCP-8.5), in the 10 models with the most realistic monsoon climatology; and 13% to 85% when all the 20 models are considered. The spread across models reduces when variability increase per degree of global warming is considered, which is independent of the scenario in most models, and is 8% ± 4%/K on average. This consistent projection across 20 comprehensive climate models provides confidence in the results and suggests the necessity of profound adaptation measures in the case of unmitigated climate change.

Health-Related Quality of Life Among Central Appalachian Residents in Mountaintop Mining Counties

PubMed Central

Hendryx, Michael

2011-01-01

Objectives. We examined the health-related quality of life of residents in mountaintop mining counties of Appalachia using the 2006 national Behavioral Risk Factor Surveillance System. Methods. Dependent variables included self-rated health; the number of poor physical, poor mental, and activity limitation days (in the past 30 days); and the Healthy Days Index. Independent variables included metropolitan status, primary care physician supply, and Behavioral Risk Factor Surveillance System behavioral and demographic variables. We compared dependent variables across 3 categories: mountaintop mining (yes or no), other coal mining (yes or no), and a referent nonmining group. We used SUDAAN MULTILOG and multiple linear regression models with post hoc least squares means to test mountaintop mining effects after adjusting for covariates. Results. Residents of mountaintop mining counties reported significantly more days of poor physical, mental, and activity limitation and poorer self-rated health (P < .01) compared with the other county groupings. Results were generally consistent in separate analyses by gender and age. Conclusions. Mountaintop mining areas are associated with the greatest reductions in health-related quality of life even when compared with counties with other forms of coal mining. PMID:21421943

Homeopathy for Perennial Asthma in Adolescents: Pilot Feasibility Study Testing a Randomised Withdrawal Design.

PubMed

Mitchiguian Hotta, Livia; Cardinalli Adler, Ubiratan; de Toledo Cesar, Amarilys; Martinez, Edson Zangiacomi; Demarzo, Marcelo Marcos Piva

2018-05-01

 Previous findings from a pragmatic trial suggest that usual care compared with usual care plus individualised homeopathy is not a feasible design to address homeopathic interventions for asthma.  The main purpose of this article was to investigate the feasibility of the randomised withdrawal design as a strategy to assess the effectiveness of a standardised clinical-pharmaceutical homeopathic protocol ( Organon.modus ) on perennial asthma in adolescents.  Randomised withdrawal, double-blind, parallel, placebo-controlled, 12-week study. 12 to 17 years old adolescents, with the diagnosis of perennial asthma, using inhalatory beclomethasone (plus fenoterol for wheezing episodes), who achieved 3 months of well-controlled asthma, after a variable period of individualised homeopathic treatment according to Organon.modus protocol. a secondary care medical specialist centre. continuation with the individualised homeopathic medicine or with indistinguishable placebo during 12 weeks of beclomethasone step-down. number of days of well-controlled asthma. Secondary measures: number of days of fenoterol use, number of visits to an emergency service (without hospitalisation) and percentage of patients excluded due to an exacerbation characterising a partly controlled asthma. Tolerability was assessed by Adverse Events, registered at every visit.  Nineteen patients were randomised to continue treatment with homeopathy and 21 with placebo. Effectiveness measures for the homeopathy and placebo groups respectively were median number of days of good clinical control: 84 versus 30 ( p  = 0.18); median number of days of fenoterol use per patient: 3 versus 5 ( p  = 0.41); visits to an emergency room: 1 versus 6 ( p  = 0.35); percentage of exclusion due to partly controlled asthma: 36.8% versus 71.4% ( p  = 0.05). Few Adverse Events were reported.  This pilot study supports the feasibility of the double-blind randomised withdrawal design in studies investigating homeopathy on teenage asthma, when performed by specialists following a standardised clinical-pharmaceutical homeopathic protocol.  RBR-6XTS8Z. The Faculty of Homeopathy.

A wearable respiratory monitoring device--the between-days variability of calibration.

PubMed

Heyde, C; Mahler, H; Roecker, K; Gollhofer, A

2015-01-01

The between-days variability in ascertained gain factors for calibration of a wearable respiratory inductance plethysmograph (RIP) and validity thereof for the repeated use during exercise were examined. Consecutive 5-min periods of standing still, slow running at 8 km·h(-1), fast running at 14 km·h(-1) (male) or 12 km·h(-1) (female) and recovery were repeated by 10 healthy subjects on 5 days. Breath-by-breath data were recorded simultaneously by flow meter and RIP. Gain factors were determined individually for each trial (CALIND) via least square regression. Reliability and variability in gain factors were quantified respectively by intraclass correlation coefficients (ICC) and limits of agreement. Within a predefined error range of ±20% the amount of RIP-derived tidal volumes after CALIND was compared to corresponding amounts when gain factors of the first trial were applied on the following 4 trials (CALFIRST). ICC ranged within 0.96 and 0.98. The variability in gain factors (up to ± 24.06%) was reduced compensatively by their sum. Amounts of breaths within the predefined error range did not differ between CALIND and (CALFIRST) (P>0.32). The between-days variability of gain factors for a wearable RIP-device does not show impaired reliability in further derived tidal volumes. © Georg Thieme Verlag KG Stuttgart · New York.

Heat and moisture exchangers in mechanically ventilated intensive care unit patients: a plea for an independent assessment of their performance.

PubMed

Thiéry, Guillaume; Boyer, Alexandre; Pigné, Etienne; Salah, Amar; De Lassence, Arnaud; Dreyfuss, Didier; Ricard, Jean-Damien

2003-03-01

To determine whether use of a hygroscopic and hydrophobic heat and moisture exchanger (HME) for 7 days without change affects its efficiency in long-term, mechanically ventilated, chronic obstructive pulmonary disease (COPD) patients. Prospective, randomized, controlled clinical study comparing two combined HMEs. Medical intensive care unit at a university teaching hospital. Long-term, mechanically ventilated, COPD patients compared with non-COPD patients. In the first part of the study, COPD patients were studied with the Hygroster HME changed once a week. For the second part, the Hygroster was assessed in non-COPD patients and compared with the Hygrobac HME used in COPD and non-COPD patients for 1 wk without change. Devices could be changed if hygrometric measurements indicated insufficient humidity delivery. Daily measurements were recorded for inspired gas temperature and relative and absolute humidity. Ventilatory variables, clinical indicators of efficient humidification, were also recorded. No tracheal tube occlusion occurred. However, contrary to the manufacturer advertisement, the Hygroster experienced surprisingly low values for absolute humidity in both COPD and non-COPD patients. Such events did not occur with the Hygrobac. Absolute humidity with the Hygroster was constantly and significantly lower during the 7-day study period than with the Hygrobac. Absolute humidity measured in COPD patients was identical to that measured in the rest of the study population with both HMEs. Manufacturer specifications and bedside measurements of absolute humidity differed considerably for the Hygroster, which in certain instances did not achieve efficient humidification in both COPD and non-COPD patients. This did not occur with the Hygrobac, which performed well throughout the 7-day period in both COPD and non-COPD patients. Our results speak for independent and evaluation of HMEs.

Sugar consumption pattern of 13-year-old school children in Belgaum city, Karnataka.

PubMed

Hegde, P P; Ashok Kumar, B R; Ankola, A

2005-01-01

To determine the sugar consumption pattern of the school children in Belgaum city and to organize for a diet-counseling program. Easy availability of sugar containing food and high consumption of these sweets if continued unabated, the dental caries among children would become a major public health problem. In this instance, Dietary counseling can be just appropriate to inhibit the carious process. 342 school children aged 13 years, from four schools in Belgaum city participated in the study. The pattern of sugar consumption was assessed using a 4-day diet diary. Analysis was done according to the method described by Nizel and Papas (Nutrition in clinical dentistry, 1989, 277) and the variables were: the sweet score, At meal sugar exposure (AMSE), Between meal sugar exposure (BMSE) and Total sugar exposure (TSE). The mean, standard deviation and/or frequency were calculated for all variables. Student's t-test was used to statistically analyze the gender difference. The mean ± SD of the recorded variables were: sweet score 31 ± 12.78/day, AMSE 0.88 ± 0.33/day, BMSE 3.95 ± 0.87/day, and TSE 4.83 ± 0.96/day. No statistical significant gender difference with respect to the variables was observed. 'Tell Show And Do' Diet counseling session will perhaps have a greater impact as compared to the most common strategy of simply exhorting the children to eat less sugar.

STS-109 Mission Highlights Resource Tape

NASA Astrophysics Data System (ADS)

2002-05-01

This video, Part 4 of 4, shows footage of crew activities from flight days 8 through 12 of STS-109. The crew included: Scott Altman, Commander; Duane Carey, Pilot; John Grunsfeld, Payload Commander; Nancy Currie, Richard Linnehan, James Newman, Michael Massimino, Mission Speicalists. The activities from other flights days can be seen on 'STS-109 Mission Highlights Resource Tape' Part 1 of 4 (internal ID 2002139471), 'STS-109 Mission Highlights Resource Tape' Part 2 of 4 (internal ID 2002137664), and 'STS-109 Mission Highlights Resource Tape' Part 3 of 4 (internal ID 2002139476). The primary activity on flight day 8 was an EVA (extravehicular activity) by Grunsfeld and Linnehan to install a cryocooler and radiator for the NICMOS (Near Infrared Camera and Multi-Object Spectrometer) on the HST (Hubble Space Telescope). Before returning to Columbia's airlock, the astronauts, with a cloudy background, hold onto the orbiter and offer their thoughts on the significance of their mission, the HST, and spaceflight. Footage from flight day 9 includes the grappling, unbearthing, and deployment of the HST from Columbia, and the crew coordinating and videotaping Columbia's departure. Flight day 10 was a relatively inactive day, and flight day 11 includes a checkout of Columbia's aerodynamic surfaces. Columbia landed on flight day 12, which is covered by footage of the crew members speaking during reentry, and their night landing, primarily shown through the orbiter's head-up display. The video includes numerous views of the HST, as well as views of the the Galapagos Islands, Madagascar, and Southern Africa with parts of the Atlantic, Indian, and Pacific Oceans, and part of the coast of Chile. The pistol grip space tool is shown in use, and the crew answers two messages from the public, including a message to Massimino from the Fire Department of New York.

Gravitational biology and the mammalian circadian timing system

NASA Technical Reports Server (NTRS)

Fuller, Charles A.; Murakami, Dean M.; Sulzman, Frank M.

1989-01-01

Using published reports, this paper compares and contrasts results on the effects of altered gravitational fields on the regulation in mammals of several physiological and behavioral variables with the circadian regulation of the same variables. The variables considered include the temperature regulation, heart rate, activity, food intake, and calcium balance. It is shown that, in rats, the homeostatic regulation of the body temperature, heart rate, and activity becomes depressed following exposure to a 2 G hyperdynamic field, and recovers within 6 days of 1 G condition. In addition, the circadian rhythms of these variables exhibit a depression of the rhythm amplitude; a recovery of this condition requires a minimum of 7 days.

Validating the Airspace Concept Evaluation System for Different Weather Days

NASA Technical Reports Server (NTRS)

Zelinski, Shannon; Meyn, Larry

2006-01-01

This paper extends the process for validating the Airspace Concept Evaluation System using real-world historical flight operational data. System inputs such as flight plans and airport en-route capacities, are generated and processed to create a realistic reproduction of a single day's operations within the National Airspace System. System outputs such as airport throughput, delays, and en-route sector loads are then compared to real world operational metrics and delay statistics for the reproduced day. The process is repeated for 4 historical days with high and low traffic volume and delay attributed to weather. These 4 days are simulated using default en-route capacities and variable en-route capacities used to emulate weather. The validation results show that default enroute capacity simulations are closer to real-world data for low weather days than high weather days. The use of reduced variable enroute capacities adds a large delay bias to ACES but delay trends between weather days are better represented.

A chrysophyte-based quantitative reconstruction of winter severity from varved lake sediments in NE Poland during the past millennium and its relationship to natural climate variability

NASA Astrophysics Data System (ADS)

Hernández-Almeida, I.; Grosjean, M.; Przybylak, R.; Tylmann, W.

2015-08-01

Chrysophyte cysts are recognized as powerful proxies of cold-season temperatures. In this paper we use the relationship between chrysophyte assemblages and the number of days below 4 °C (DB4 °C) in the epilimnion of a lake in northern Poland to develop a transfer function and to reconstruct winter severity in Poland for the last millennium. DB4 °C is a climate variable related to the length of the winter. Multivariate ordination techniques were used to study the distribution of chrysophytes from sediment traps of 37 low-land lakes distributed along a variety of environmental and climatic gradients in northern Poland. Of all the environmental variables measured, stepwise variable selection and individual Redundancy analyses (RDA) identified DB4 °C as the most important variable for chrysophytes, explaining a portion of variance independent of variables related to water chemistry (conductivity, chlorides, K, sulfates), which were also important. A quantitative transfer function was created to estimate DB4 °C from sedimentary assemblages using partial least square regression (PLS). The two-component model (PLS-2) had a coefficient of determination of Rcross2 = 0.58, with root mean squared error of prediction (RMSEP, based on leave-one-out) of 3.41 days. The resulting transfer function was applied to an annually-varved sediment core from Lake Żabińskie, providing a new sub-decadal quantitative reconstruction of DB4 °C with high chronological accuracy for the period AD 1000-2010. During Medieval Times (AD 1180-1440) winters were generally shorter (warmer) except for a decade with very long and severe winters around AD 1260-1270 (following the AD 1258 volcanic eruption). The 16th and 17th centuries and the beginning of the 19th century experienced very long severe winters. Comparison with other European cold-season reconstructions and atmospheric indices for this region indicates that large parts of the winter variability (reconstructed DB4 °C) is due to the interplay between the oscillations of the zonal flow controlled by the North Atlantic Oscillation (NAO) and the influence of continental anticyclonic systems (Siberian High, East Atlantic/Western Russia pattern). Differences with other European records are attributed to geographic climatological differences between Poland and Western Europe (Low Countries, Alps). Striking correspondence between the combined volcanic and solar forcing and the DB4 °C reconstruction prior to the 20th century suggests that winter climate in Poland responds mostly to natural forced variability (volcanic and solar) and the influence of unforced variability is low.

Within-patient temporal variance in MELD score and impact on survival prediction after TIPS creation.

PubMed

Gaba, Ron C; Shah, Kruti D; Couture, Patrick M; Parvinian, Ahmad; Minocha, Jeet; Knuttinen, M Grace; Bui, James T

2013-01-01

To assess within-patient temporal variability in Model for End Stage Liver Disease (MELD) scores and impact on outcome prognostication after transjugular intrahepatic portosystemic shunt (TIPS) creation. In this single institution retrospective study, MELD score was calculated in 68 patients (M:F = 42:26, mean age 55 years) at 4 pre-procedure time points (1, 2-6, 7-14, and 15-35 days) before TIPS creation. Medical record review was used to identify 30- and 90-day clinical outcomes. Within-patient variability in pre-procedure MELD scores was assessed using repeated measures analysis of variance, and the ability of MELD scores at different time points to predict post-TIPS mortality was evaluated by comparing area under receiver operating characteristic (AUROC) curves. TIPS were successfully created for ascites (n = 30), variceal hemorrhage (n = 29), hepatic hydrothorax (n = 8), and portal vein thrombosis (n = 1). Pre-TIPS MELD scores showed significant (P = 0.032) within-subject variance that approached ± 18.5%. Higher MELD scores demonstrated greater variability in sequential scores as compared to lower MELD scores. Overall 30- and 90-day patient mortality was 22% (15/67) and 38% (24/64). AUROC curves showed that most recent MELD scores performed on the day of TIPS had superior predictive capacity for 30- (0.876, P = 0.037) and 90-day (0.805 P = 0.020) mortality compared to MELD scores performed 2-6 or 7-14 days prior. In conclusion, MELD scores show within-patient variability over time, and scores calculated on the day of TIPS most accurately predict risk and should be used for patient selection and counseling.

Comparison of a step-down dose of once-daily ciclesonide with a continued dose of twice-daily fluticasone propionate in maintaining control of asthma.

PubMed

Knox, A; Langan, J; Martinot, J-B; Gruss, C; Häfner, D

2007-10-01

To compare a step-down approach in well-controlled asthma patients, as recommended by treatment guidelines, from fluticasone propionate 250 microg twice daily (FP250 BID), or equivalent, to ciclesonide 160 microg once daily (CIC160 OD) with continued FP250 BID treatment. Patients with well-controlled asthma prior to study entry were included in two identical, randomized, double-blind, double-dummy, parallel-group studies. After a 2-week run-in period with FP250 BID, patients were randomized to CIC160 OD (n = 58) or FP250 BID (n = 53) for 12 weeks. Primary endpoints were percentage of days with asthma control, asthma symptom-free days, rescue medication-free days and nocturnal awakening-free days. Secondary endpoints included lung function variables, asthma symptom scores, rescue medication use and asthma exacerbations. Safety variables were also recorded. Patients had >or= 97% of days with asthma control, 98% asthma symptom-free days and 100% of days free from rescue medication use and nocturnal awakenings in both treatment groups (median values). There were no significant between-treatment differences for any of the primary or secondary efficacy variables. Overall, 42 treatment-emergent adverse events (TEAEs) were reported in the CIC160 OD group and 49 TEAEs were reported in the FP250 BID group. There were no clinically relevant changes from baseline in the safety variables in either treatment group. Patients well controlled on FP250 BID, or equivalent, who were stepped down to CIC160 OD, maintained similar asthma control compared with patients who received continued treatment standardized to FP250 BID.

The Sensitivity of WRF Daily Summertime Simulations over West Africa to Alternative Parameterizations. Part 1: African Wave Circulation

NASA Technical Reports Server (NTRS)

Noble, Erik; Druyan, Leonard M.; Fulakeza, Matthew

2014-01-01

The performance of the NCAR Weather Research and Forecasting Model (WRF) as a West African regional-atmospheric model is evaluated. The study tests the sensitivity of WRF-simulated vorticity maxima associated with African easterly waves to 64 combinations of alternative parameterizations in a series of simulations in September. In all, 104 simulations of 12-day duration during 11 consecutive years are examined. The 64 combinations combine WRF parameterizations of cumulus convection, radiation transfer, surface hydrology, and PBL physics. Simulated daily and mean circulation results are validated against NASA's Modern-Era Retrospective Analysis for Research and Applications (MERRA) and NCEP/Department of Energy Global Reanalysis 2. Precipitation is considered in a second part of this two-part paper. A wide range of 700-hPa vorticity validation scores demonstrates the influence of alternative parameterizations. The best WRF performers achieve correlations against reanalysis of 0.40-0.60 and realistic amplitudes of spatiotemporal variability for the 2006 focus year while a parallel-benchmark simulation by the NASA Regional Model-3 (RM3) achieves higher correlations, but less realistic spatiotemporal variability. The largest favorable impact on WRF-vorticity validation is achieved by selecting the Grell-Devenyi cumulus convection scheme, resulting in higher correlations against reanalysis than simulations using the Kain-Fritch convection. Other parameterizations have less-obvious impact, although WRF configurations incorporating one surface model and PBL scheme consistently performed poorly. A comparison of reanalysis circulation against two NASA radiosonde stations confirms that both reanalyses represent observations well enough to validate the WRF results. Validation statistics for optimized WRF configurations simulating the parallel period during 10 additional years are less favorable than for 2006.

Day-to-day consistency of lower extremity kinematics during stair ambulation in 24-45 years old athletes.

PubMed

Husa-Russell, Johanna; Ukelo, Thomas; List, Renate; Lorenzetti, Silvio; Wolf, Peter

2011-04-01

Before making interpretations on the effects of interventions or on the features of pathological gait patterns during stair ambulation, the day-to-day consistency of the investigated variables must be established. In this article, the day-to-day consistency was determined for kinematic variables during barefoot stair ambulation. Ten healthy athletes performed two gait analysis sessions, at least one week apart, utilizing a marker set of 47 skin markers, and a functional joint center/axes determination. Being found on limits of agreement and mean differences between the repeated stair ambulation sessions, totally 43 ranges of motions were examined at the hip, knee, ankle, and midfoot joints. The day-to-day consistency was generally in the magnitude of three degrees, irrespective of test condition, investigated joint, or regarded cardinal body plane. The reported values of the day-to-day consistency provide guidelines to distinguish between pathological and healthy gait patterns, and thresholds to determine minimal effects of interventions during stair ambulation. Copyright © 2011 Elsevier B.V. All rights reserved.

42 CFR 423.584 - Expediting certain redeterminations.

Code of Federal Regulations, 2010 CFR

2010-10-01

...). The 7 calendar day period begins the day the Part D plan sponsor receives the request for expedited... prescriber may request that a Part D plan sponsor expedite a redetermination that involves the issues... directly to the Part D plan sponsor or, if applicable, to the entity responsible for making the...

Radio/X-ray monitoring of the broad-line radio galaxy 3C 382. High-energy view with XMM-Newtonand NuSTAR

NASA Astrophysics Data System (ADS)

Ursini, F.; Petrucci, P.-O.; Matt, G.; Bianchi, S.; Cappi, M.; Dadina, M.; Grandi, P.; Torresi, E.; Ballantyne, D. R.; De Marco, B.; De Rosa, A.; Giroletti, M.; Malzac, J.; Marinucci, A.; Middei, R.; Ponti, G.; Tortosa, A.

2018-05-01

We present the analysis of five joint XMM-Newton/NuSTARobservations, 20 ks each and separated by 12 days, of the broad-line radio galaxy 3C 382. The data were obtained as part of a campaign performed in September-October 2016 simultaneously with VLBA. The radio data and their relation with the X-ray ones will be discussed in a following paper. The source exhibits a moderate flux variability in the UV/X-ray bands, and a limited spectral variability especially in the soft X-ray band. In agreement with past observations, we find the presence of a warm absorber, an iron Kα line with no associated Compton reflection hump, and a variable soft excess well described by a thermal Comptonization component. The data are consistent with a "two-corona" scenario, in which the UV emission and soft excess are produced by a warm (kT ≃ 0.6 keV), optically thick (τ ≃ 20) corona consistent with being a slab fully covering a nearly passive accretion disc, while the hard X-ray emission is due to a hot corona intercepting roughly 10% of the soft emission. These results are remarkably similar to those generally found in radio-quiet Seyferts, thus suggesting a common accretion mechanism.

Long-Period Variability in o Ceti

NASA Astrophysics Data System (ADS)

Templeton, Matthew R.; Karovska, Margarita

2009-02-01

We carried out a new and sensitive search for long-period variability in the prototype of the Mira class of long-period pulsating variables, o Ceti (Mira A), the closest and brightest Mira variable. We conducted this search using an unbroken light curve from 1902 to the present, assembled from the visual data archives of five major variable star observing organizations from around the world. We applied several time-series analysis techniques to search for two specific kinds of variability: long secondary periods (LSPs) longer than the dominant pulsation period of ~333 days, and long-term period variation in the dominant pulsation period itself. The data quality is sufficient to detect coherent periodic variations with photometric amplitudes of 0.05 mag or less. We do not find evidence for coherent LSPs in o Ceti to a limit of 0.1 mag, where the amplitude limit is set by intrinsic, stochastic, low-frequency variability of approximately 0.1 mag. We marginally detect a slight modulation of the pulsation period similar in timescale to that observed in the Miras with meandering periods, but with a much lower period amplitude of ±2 days. However, we do find clear evidence of a low-frequency power-law component in the Fourier spectrum of o Ceti's long-term light curve. The amplitude of this stochastic variability is approximately 0.1 mag at a period of 1000 days, and it exhibits a turnover for periods longer than this. This spectrum is similar to the red noise spectra observed in red supergiants.

Quantifying spatiotemporal variability of fine particles in an urban environment using combined fixed and mobile measurements

NASA Astrophysics Data System (ADS)

Sullivan, R. C.; Pryor, S. C.

2014-06-01

Spatiotemporal variability of fine particle concentrations in Indianapolis, Indiana is quantified using a combination of high temporal resolution measurements at four fixed sites and mobile measurements with instruments attached to bicycles during transects of the city. Average urban PM2.5 concentrations are an average of ˜3.9-5.1 μg m-3 above the regional background. The influence of atmospheric conditions on ambient PM2.5 concentrations is evident with the greatest temporal variability occurring at periods of one day and 5-10 days corresponding to diurnal and synoptic meteorological processes, and lower mean wind speeds are associated with episodes of high PM2.5 concentrations. An anthropogenic signal is also evident. Higher PM2.5 concentrations coincide with morning rush hour, the frequencies of PM2.5 variability co-occur with those for carbon monoxide, and higher extreme concentrations were observed mid-week compared to weekends. On shorter time scales (

Safety and efficacy of neratinib in combination with capecitabine in patients with metastatic human epidermal growth factor receptor 2-positive breast cancer.

PubMed

Saura, Cristina; Garcia-Saenz, Jose A; Xu, Binghe; Harb, Wael; Moroose, Rebecca; Pluard, Timothy; Cortés, Javier; Kiger, Corinne; Germa, Caroline; Wang, Kongming; Martin, Miguel; Baselga, José; Kim, Sung-Bae

2014-11-10

Neratinib is a potent irreversible pan-tyrosine kinase inhibitor with antitumor activity and acceptable tolerability in patients with human epidermal growth factor receptor 2 (HER2) -positive breast cancer. A multinational, open-label, phase I/II trial was conducted to determine the maximum-tolerated dose (MTD) of neratinib plus capecitabine in patients with solid tumors (part one) and to evaluate the safety and efficacy of neratinib plus capecitabine in patients with HER2-positive metastatic breast cancer (part two). Part one was a 3 + 3 dose-escalation study in which patients with advanced solid tumors received oral neratinib once per day continuously plus capecitabine twice per day on days 1 to 14 of a 21-day cycle at predefined dose levels. In part two, patients with trastuzumab-pretreated HER2-positive metastatic breast cancer received neratinib plus capecitabine at the MTD. The primary end point in part two was objective response rate (ORR). In part one (n = 33), the combination of neratinib 240 mg per day plus capecitabine 1,500 mg/m(2) per day was defined as the MTD, which was further evaluated in part 2 (n = 72). The most common drug-related adverse events were diarrhea (88%) and palmar-plantar erythrodysesthesia syndrome (48%). In part two, the ORR was 64% (n = 39 of 61) in patients with no prior lapatinib exposure and 57% (n = 4 of 7) in patients previously treated with lapatinib. Median progression-free survival was 40.3 and 35.9 weeks, respectively. Neratinib in combination with capecitabine had a manageable toxicity profile and showed promising antitumor activity in patients with HER2-positive metastatic breast cancer pretreated with trastuzumab and lapatinib. © 2014 by American Society of Clinical Oncology.

Effects of robotically modulating kinematic variability on motor skill learning and motivation

PubMed Central

Reinkensmeyer, David J.

2015-01-01

It is unclear how the variability of kinematic errors experienced during motor training affects skill retention and motivation. We used force fields produced by a haptic robot to modulate the kinematic errors of 30 healthy adults during a period of practice in a virtual simulation of golf putting. On day 1, participants became relatively skilled at putting to a near and far target by first practicing without force fields. On day 2, they warmed up at the task without force fields, then practiced with force fields that either reduced or augmented their kinematic errors and were finally assessed without the force fields active. On day 3, they returned for a long-term assessment, again without force fields. A control group practiced without force fields. We quantified motor skill as the variability in impact velocity at which participants putted the ball. We quantified motivation using a self-reported, standardized scale. Only individuals who were initially less skilled benefited from training; for these people, practicing with reduced kinematic variability improved skill more than practicing in the control condition. This reduced kinematic variability also improved self-reports of competence and satisfaction. Practice with increased kinematic variability worsened these self-reports as well as enjoyment. These negative motivational effects persisted on day 3 in a way that was uncorrelated with actual skill. In summary, robotically reducing kinematic errors in a golf putting training session improved putting skill more for less skilled putters. Robotically increasing kinematic errors had no performance effect, but decreased motivation in a persistent way. PMID:25673732

Effects of robotically modulating kinematic variability on motor skill learning and motivation.

PubMed

Duarte, Jaime E; Reinkensmeyer, David J

2015-04-01

It is unclear how the variability of kinematic errors experienced during motor training affects skill retention and motivation. We used force fields produced by a haptic robot to modulate the kinematic errors of 30 healthy adults during a period of practice in a virtual simulation of golf putting. On day 1, participants became relatively skilled at putting to a near and far target by first practicing without force fields. On day 2, they warmed up at the task without force fields, then practiced with force fields that either reduced or augmented their kinematic errors and were finally assessed without the force fields active. On day 3, they returned for a long-term assessment, again without force fields. A control group practiced without force fields. We quantified motor skill as the variability in impact velocity at which participants putted the ball. We quantified motivation using a self-reported, standardized scale. Only individuals who were initially less skilled benefited from training; for these people, practicing with reduced kinematic variability improved skill more than practicing in the control condition. This reduced kinematic variability also improved self-reports of competence and satisfaction. Practice with increased kinematic variability worsened these self-reports as well as enjoyment. These negative motivational effects persisted on day 3 in a way that was uncorrelated with actual skill. In summary, robotically reducing kinematic errors in a golf putting training session improved putting skill more for less skilled putters. Robotically increasing kinematic errors had no performance effect, but decreased motivation in a persistent way. Copyright © 2015 the American Physiological Society.

A Poisson regression approach to model monthly hail occurrence in Northern Switzerland using large-scale environmental variables

NASA Astrophysics Data System (ADS)

Madonna, Erica; Ginsbourger, David; Martius, Olivia

2018-05-01

In Switzerland, hail regularly causes substantial damage to agriculture, cars and infrastructure, however, little is known about its long-term variability. To study the variability, the monthly number of days with hail in northern Switzerland is modeled in a regression framework using large-scale predictors derived from ERA-Interim reanalysis. The model is developed and verified using radar-based hail observations for the extended summer season (April-September) in the period 2002-2014. The seasonality of hail is explicitly modeled with a categorical predictor (month) and monthly anomalies of several large-scale predictors are used to capture the year-to-year variability. Several regression models are applied and their performance tested with respect to standard scores and cross-validation. The chosen model includes four predictors: the monthly anomaly of the two meter temperature, the monthly anomaly of the logarithm of the convective available potential energy (CAPE), the monthly anomaly of the wind shear and the month. This model well captures the intra-annual variability and slightly underestimates its inter-annual variability. The regression model is applied to the reanalysis data back in time to 1980. The resulting hail day time series shows an increase of the number of hail days per month, which is (in the model) related to an increase in temperature and CAPE. The trend corresponds to approximately 0.5 days per month per decade. The results of the regression model have been compared to two independent data sets. All data sets agree on the sign of the trend, but the trend is weaker in the other data sets.

Systolic blood pressure variability in patients with early severe sepsis or septic shock: a prospective cohort study.

PubMed

Tang, Yi; Sorenson, Jeff; Lanspa, Michael; Grissom, Colin K; Mathews, V J; Brown, Samuel M

2017-06-17

Severe sepsis and septic shock are often lethal syndromes, in which the autonomic nervous system may fail to maintain adequate blood pressure. Heart rate variability has been associated with outcomes in sepsis. Whether systolic blood pressure (SBP) variability is associated with clinical outcomes in septic patients is unknown. The propose of this study is to determine whether variability in SBP correlates with vasopressor independence and mortality among septic patients. We prospectively studied patients with severe sepsis or septic shock, admitted to an intensive care unit (ICU) with an arterial catheter. We analyzed SBP variability on the first 5-min window immediately following ICU admission. We performed principal component analysis of multidimensional complexity, and used the first principal component (PC 1 ) as input for Firth logistic regression, controlling for mean systolic pressure (SBP) in the primary analyses, and Acute Physiology and Chronic Health Evaluation (APACHE) II score or NEE dose in the ancillary analyses. Prespecified outcomes were vasopressor independence at 24 h (primary), and 28-day mortality (secondary). We studied 51 patients, 51% of whom achieved vasopressor independence at 24 h. Ten percent died at 28 days. PC 1 represented 26% of the variance in complexity measures. PC 1 was not associated with vasopressor independence on Firth logistic regression (OR 1.04; 95% CI: 0.93-1.16; p = 0.54), but was associated with 28-day mortality (OR 1.16, 95% CI: 1.01-1.35, p = 0.040). Early SBP variability appears to be associated with 28-day mortality in patients with severe sepsis and septic shock.

[Dust storms trend in the Capital Circle of China over the past 50 years and its correlation with temperature, precipitation and wind].

PubMed

Chen, Yu-fu; Tang, Hai-ping

2005-01-01

The trends of number of dust storm days of the selected 11 meteorological stations from their established year to 2000 as well as their correlations with temperature, precipitation and wind are revealed. The number of dust storm days of the Capital Circle of China is distinctly variable in space and time. The numbers of dust storm days of the western area are far more than those of the eastern area. The interannual variability of number of dust storm days is remarkable. The number of dust storm days of the following 7 stations, Erlianhaote, Abaga, Xilinhaote, Fengning, Zhangjiakou, Huailai and Beijing, declined along the past decades, but those of the other four stations had no significant upward or downward trends. There is a marked seasonality of the number of dust storm days, and the maximum was in April. The correlation between number of dust storm days and number of days of mean wind velocity > 5 m/s, which is critical wind velocity to entrain sand into the air, was strongest among the three climatic factor. There were significant positive correlations between the number of dust storm days and number of days of mean wind velocity > 5 m/s in 6 stations. The second strongest climatic factor correlated with the number of dust storm days is temperature. There are significant negative correlations between the number of dust storm days and mean annual temperature, mean winter temperature, mean spring temperature in 3 or 4 stations. The correlation between the number of dust storm days and precipitation is weakest. Only one station, Zhurihe, showes significant negative correlation between the number of dust storm days and spring rainfall. There are 4 stations whose number of dust storm days don't significantly correlate with the climate. In the end, the spatial-temporal variability of dust storms and its relation with climate in the Capital Circle of China were discussed thoroughly.

How do measurement duration and timing interact to influence estimation of basal physiological variables of a nocturnal rodent?

PubMed

Connolly, M K; Cooper, C E

2014-12-01

Metabolic rate and evaporative water loss are two commonly measured physiological variables. It is therefore important, especially for comparative studies, that these variables (and others) are measured under standardised conditions, of which a resting state during the inactive phase is part of the accepted criteria. Here we show how measurement duration and timing affect these criteria and impact on the estimation of basal metabolic rate (oxygen consumption and carbon dioxide production) and standard evaporative water loss of a small nocturnal rodent. Oxygen consumption, carbon dioxide production and evaporative water loss all decreased over the duration of an experiment. Random assortment of hourly values indicated that this was an animal rather than a random effect for up to 11h. Experimental start time also had a significant effect on measurement of physiological variables. A longer time period was required to achieve minimal carbon dioxide consumption and evaporative water loss when experiments commenced earlier in the day; however, experiments with earlier start times had a lower overall estimates of minimal oxygen consumption and carbon dioxide production. For this species, measurement duration of at least 8h, ideally commencing between before the inactive phase at 03:00h and 05:00h, is required to obtain minimal standard values for physiological variables. Up to 80% of recently published studies measuring basal metabolic rate and/or evaporative water loss of small nocturnal mammals may overestimate basal values due to insufficiently long measurement duration. Copyright © 2014 Elsevier Inc. All rights reserved.

Impact of non-migrating tides on the low latitude ionosphere during a sudden stratospheric warming event in January 2010

NASA Astrophysics Data System (ADS)

McDonald, S. E.; Sassi, F.; Tate, J.; McCormack, J.; Kuhl, D. D.; Drob, D. P.; Metzler, C.; Mannucci, A. J.

2018-06-01

The lower atmosphere contributes significantly to the day-to-day variability of the ionosphere, especially during solar minimum conditions. Ionosphere/atmosphere model simulations that incorporate meteorology from data assimilation analysis products can be critically important for elucidating the physical processes that have substantial impact on ionospheric weather. In this study, the NCAR Whole Atmosphere Community Climate Model, extended version with specified dynamics (SD-WACCM-X) is coupled with an ionospheric model (Sami3 is Another Model of the Ionosphere) to study day-to-day variability in the ionosphere during January 2010. Lower atmospheric weather patterns are introduced into the SAMI3/SD-WACCM-X simulations using the 6-h Navy Operational Global Atmospheric Prediction System-Advanced Level Physics High Altitude (NOGAPS-ALPHA) data assimilation products. The same time period is simulated using the new atmospheric forecast model, the High Altitude Navy Global Environmental Model (HA-NAVGEM), a hybrid 4D-Var prototype data assimilation with the ability to produce meteorological fields at a 3-h cadence. Our study shows that forcing SD-WACCM-X with HA-NAVGEM better resolves the semidiurnal tides and introduces more day-to-day variability into the ionosphere than forcing with NOGAPS-ALPHA. The SAMI3/SD-WACCM-X/HA-NAVGEM simulation also more accurately captures the longitudinal variability associated with non-migrating tides in the equatorial ionization anomaly (EIA) region as compared to total electron content (TEC) maps derived from GPS data. Both the TEC maps and the SAMI3/SD-WACCM-X/HA-NAVGEM simulation show an enhancement in TEC over South America during 17-21 January 2010, which coincides with the commencement of a stratospheric warming event on 19 January 2010. Analysis of the SAMI3/SD-WACCM-X/HA-NAVGEM simulations indicates non-migrating tides (including DW4, DE2 and SW5) played a role during 17-21 January in shifting the phase of the wave-3 pattern in the ionosphere on these days. Constructive interference of wave-3 and wave-4 patterns in the E × B drifts contributed to the enhanced TEC in the South American longitude sector. The results of the study highlight the importance of high fidelity meteorology in understanding the day-to-day variability of the ionosphere.

Effect of 16-hour duty periods on patient care and resident education.

PubMed

McCoy, Christopher P; Halvorsen, Andrew J; Loftus, Conor G; McDonald, Furman S; Oxentenko, Amy S

2011-03-01

To measure the effect of duty periods no longer than 16 hours on patient care and resident education. As part of our Educational Innovations Project, we piloted a novel resident schedule for an inpatient service that eliminated shifts longer than 16 hours without increased staffing or decreased patient admissions on 2 gastroenterology services from August 29 to November 27, 2009. Patient care variables were obtained through medical record review. Resident well-being and educational variables were collected by weekly surveys, end of rotation evaluations, and an electronic card-swipe system. Patient care metrics, including 30-day mortality, 30-day readmission rate, and length of stay, were unchanged for the 196 patient care episodes in the 5-week intervention month compared with the 274 episodes in the 8 weeks of control months. However, residents felt less prepared to manage cross-cover of patients (P = .006). There was a nonsignificant trend toward decreased perception of quality of education and balance of personal and professional life during the intervention month. Residents reported working fewer weekly hours overall during the intervention (64.3 vs 68.9 hours; P = .40), but they had significantly more episodes with fewer than 10 hours off between shifts (24 vs 2 episodes; P = .004). Inpatient hospital services can be staffed with residents working shifts less than 16 hours without additional residents. However, cross-cover of care, quality of education, and time off between shifts may be adversely affected.

Dietary tendencies as predictors of marathon time in novice marathoners.

PubMed

Wilson, Patrick B; Ingraham, Stacy J; Lundstrom, Chris; Rhodes, Gregory

2013-04-01

The effects of dietary factors such as carbohydrate (CHO) on endurance-running performance have been extensively studied under laboratory-based and simulated field conditions. Evidence from "real-life" events, however, is poorly characterized. The purpose of this observational study was to examine the associations between prerace and in-race nutrition tendencies and performance in a sample of novice marathoners. Forty-six college students (36 women and 10 men) age 21.3 ± 3.3 yr recorded diet for 3 d before, the morning of, and during a 26.2-mile marathon. Anthropometric, physiological, and performance measurements were assessed before the marathon so the associations between diet and marathon time could be included as part of a stepwise-regression model. Mean marathon time was 266 ± 42 min. A pre-marathon 2-mile time trial explained 73% of the variability in marathon time (adjusted R2 = .73, p < .001). Day-before + morning-of CHO (DBMC) was the only other significant predictor of marathon time, explaining an additional 4% of the variability in marathon time (adjusted R2 = .77, p = .006). Other factors such as age, body-mass index, gender, day-before + morning-of energy, and in-race CHO were not significant independent predictors of marathon time. In this sample of primarily novice marathoners, DBMC intake was associated with faster marathon time, independent of other known predictors. These results suggest that novice and recreational marathoners should consider consuming a moderate to high amount of CHO in the 24-36 hr before a marathon.

Characterization of Industrial Emission Sources and Photochemistry in Houston, Texas

NASA Astrophysics Data System (ADS)

Washenfelder, R. A.; Atlas, E. L.; Degouw, J.; Flocke, F. M.; Fried, A.; Frost, G. J.; Holloway, J.; Richter, D.; Ryerson, T. B.; Schauffler, S.; Trainer, M.; Walega, J.; Warneke, C.; Weibring, P.; Zheng, W.

2009-12-01

The Houston-Galveston urban area contains a number of large industrial petrochemical emission sources that produce volatile organic compounds and nitrogen oxides. These co-located emissions result in rapid and efficient ozone production downwind. Unlike a single large power plant, the industrial complexes consist of numerous sources that can be difficult to quantify in emission inventories. During September - October 2006, the NOAA WP-3 aircraft conducted research flights as part of the second Texas Air Quality Study (TexAQS II). We examine measurements of NOx, SO2, and speciated hydrocarbons from the Houston Ship Channel, which contains a dense concentration of industrial petrochemical sources, and isolated petrochemical facilities. These measurements are used to derive source emission estimates, which are then compared to available emission inventories. We find that high hydrocarbon emissions are typical for the Houston Ship Channel and isolated petrochemical facilities. Ethene and propene are found to be major contributors to ozone formation. Ratios of C2H4 / NOx and C3H6 / NOx exceed emission inventory values by factors of 10 - 50. These findings are consistent with the first TexAQS study in 2000. We examine trends in C2H4 / NOx and C3H6 / NOx ratios between 2000 and 2006, and determine that day-to-day variability and within-plume variability exceeds any long-term reduction in ethene and propene emissions for the isolated petrochemical sources. We additionally examine downwind photochemical products formed by these alkenes.

Effect of Variable Doses of Zinc Oxide Nanoparticles on Male Albino Mice Behavior.

PubMed

Zahra, Javeria; Iqbal, Shahid; Zahra, Kiran; Javed, Zulha; Shad, Muhammad Aslam; Akbar, Atif; Ashiq, Muhammad Naeem; Iqbal, Furhan

2017-02-01

Zinc oxide nanoparticles (ZnO NPs) have diverse utility these days ranging from being part of nanosensors to be ingredient of cosmetics. Present study was designed to report the effect of variable doses of ZnO NPs on selected aspects of male albino mice behavior. Nano particles were synthesized by sol-gel auto-combustion method (Data not shown here). 10 week old male albino mice were divided into four experimental groups; group A, B and C were orally supplemented with 50 (low dose), 300 (medium dose) and 600 mg/ml solvent/kg body weight (high dose) of ZnO NPs for 4 days. Group D (control) orally received 0.2 M sodium phosphate buffer (solvent for ZnO NPs) for the same duration. A series of neurological tests (Rota rod, open field, novel object and light-dark box test) were conducted in all groups and performance was compared between ZnO NPs treated and control group. Muscular functioning during rota rod test was significantly improved in all ZnO NPs treated mice as compared to control group. While no significant differences in open field, novel object and light-dark box test performance were observed when data from studied parameters of specific ZnO NPs treatment were compared with the control group indicating that applied doses of ZnO NPs did not affect the exploratory, anxiolytic behavior and object recognition capability of adult male albino mice.

Analysis of risk factors for central venous catheter-related complications: a prospective observational study in pediatric patients with bone sarcomas.

PubMed

Abate, Massimo Eraldo; Sánchez, Olga Escobosa; Boschi, Rita; Raspanti, Cinzia; Loro, Loretta; Affinito, Domenico; Cesari, Marilena; Paioli, Anna; Palmerini, Emanuela; Ferrari, Stefano

2014-01-01

The incidence of central venous catheter (CVC)-related complications reported in pediatric sarcoma patients is not established as reports in available literature are limited. The analysis of risk factors is part of the strategy to reduce the incidence of CVC complications. The objective of this study was to determine the incidence of CVC complications in children with bone sarcomas and if defined clinical variables represent a risk factor. During an 8-year period, 155 pediatric patients with bone sarcomas were prospectively followed up for CVC complications. Incidence and correlation with clinical features including gender, age, body mass index, histology, disease stage, and use of thromboprophylaxis with low-molecular-weight heparin were analyzed. Thirty-three CVC complications were recorded among 42 687 CVC-days (0.77 per 1000 CVC-days). No correlation between the specific clinical variables and the CVC complications was found. A high incidence of CVC-related sepsis secondary to gram-negative bacteria was observed. The analysis of CVC complications and their potential risk factors in this sizable and relatively homogeneous pediatric population with bone sarcomas has led to the implementation of a multimodal approach by doctors and nurses to reduce the incidence and morbidity of the CVC-related infections, particularly those related to gram-negative bacteria. As a result of this joint medical and nursing study, a multimodal approach that included equipping faucets with water filters, the reeducation of doctors and nurses, and the systematic review of CVC protocol was implemented.

Three-dimensional development of the upper dental arch in unilateral cleft lip and palate patients after early neonatal cheiloplasty.

PubMed

Hoffmannova, E; Moslerová, V; Dupej, J; Borský, J; Bejdová, Š; Velemínská, J

2018-06-01

This prospective morphometric study evaluated the growth of the upper dental arch in UCLP patients after early neonatal cheiloplasty and compared the selected dimensions with published data on non-cleft controls and on later operation protocol patients. The sample comprised 36 Czech children with nonsyndromic complete UCLP (cUCLP) and 20 Czech children with nonsyndromic incomplete UCLP (UCLP + b). 2-D and 3-D analyses of palatal casts were made at two time points: before neonatal cheiloplasty at the mean age of 3 days (±1 day), and 10 months after surgery at the mean age of 10 months (±1 month). The upper dental arch of cUCLP and UCLP + b patients showed similar developmental changes, but the cleft type influenced growth significantly. The initial high shape variability in cUCLP patients diminished after 10 months, and approached the variability in UCLP + b patients. Both the width and length dimensions increased after surgery. Important growth concerned the anterior ends of both segments. The width and length dimensions illustrated similar growth trends with non-cleft controls and UCLP patients who underwent later cheiloplasty. Early neonatal cheiloplasty caused no reduction in the length or width dimensions during the first year of life. Our data suggest a reconstructed lip has a natural formative effect on the actively growing anterior parts of upper dental arch segments, which cause narrowing of the alveolar cleft. Copyright © 2018 Elsevier B.V. All rights reserved.

Effect of 16-Hour Duty Periods on Patient Care and Resident Education

PubMed Central

McCoy, Christopher P.; Halvorsen, Andrew J.; Loftus, Conor G.; McDonald, Furman S.; Oxentenko, Amy S.

2011-01-01

OBJECTIVE: To measure the effect of duty periods no longer than 16 hours on patient care and resident education. PATIENTS AND METHODS: As part of our Educational Innovations Project, we piloted a novel resident schedule for an inpatient service that eliminated shifts longer than 16 hours without increased staffing or decreased patient admissions on 2 gastroenterology services from August 29 to November 27, 2009. Patient care variables were obtained through medical record review. Resident well-being and educational variables were collected by weekly surveys, end of rotation evaluations, and an electronic card-swipe system. RESULTS: Patient care metrics, including 30-day mortality, 30-day readmission rate, and length of stay, were unchanged for the 196 patient care episodes in the 5-week intervention month compared with the 274 episodes in the 8 weeks of control months. However, residents felt less prepared to manage cross-cover of patients (P=.006). There was a nonsignificant trend toward decreased perception of quality of education and balance of personal and professional life during the intervention month. Residents reported working fewer weekly hours overall during the intervention (64.3 vs 68.9 hours; P=.40), but they had significantly more episodes with fewer than 10 hours off between shifts (24 vs 2 episodes; P=.004). CONCLUSION: Inpatient hospital services can be staffed with residents working shifts less than 16 hours without additional residents. However, cross-cover of care, quality of education, and time off between shifts may be adversely affected. PMID:21307390

Variability of total step activity in children with cerebral palsy: influence of definition of a day on participant retention within the study.

PubMed

Wilson, Nichola C; Mudge, Suzie; Stott, N Susan

2016-08-20

Activity monitoring is important to establish accurate daily physical activity levels in children with cerebral palsy (CP). However, few studies address issues around inclusion or exclusion of step count data; in particular, how a valid day should be defined and what impact different lengths of monitoring have on retention of participant data within a study. This study assessed how different 'valid day' definitions influenced inclusion of participant data in final analyses and the subsequent variability of the data. Sixty-nine children with CP were fitted with a StepWatch™ Activity Monitor and instructed to wear it for a week. Data analysis used two broad definitions of a day, based on either number of steps in a 24 h monitoring period or the number of hours of recorded activity in a 24 h monitoring period. Eight children either did not use the monitor, or used it for only 1 day. The remaining 61 children provided 2 valid days of monitoring defined as >100 recorded steps per 24 h period and 55 (90 %) completed 2 valid days of monitoring with ≥10 h recorded activity per 24 h period. Performance variability in daily step count was lower across 2 days of monitoring when a valid day was defined as ≥10 h recorded activity per 24 h period (ICC = 0.765) and, higher when the definition >100 recorded steps per 24 h period (ICC = 0.62). Only 46 participants (75 %) completed 5 days of monitoring with >100 recorded steps per 24 h period and only 23 (38 %) achieved 5 days of monitoring with ≥10 h recorded activity per 24 h period. Datasets of participants who functioned at GMFCS level II were differentially excluded when the criteria for inclusion in final analysis was 5 valid days of ≥10 h recorded activity per 24 h period, leaving datasets available for only 8 of 32 participant datasets retained in the study. We conclude that changes in definition of a valid day have significant impacts on both inclusion of participant data in final analysis and measured variability of total step count.

Supervision of dynamic systems: Monitoring, decision-making and control

NASA Technical Reports Server (NTRS)

White, T. N.

1982-01-01

Effects of task variables on the performance of the human supervisor by means of modelling techniques are discussed. The task variables considered are: The dynamics of the system, the task to be performed, the environmental disturbances and the observation noise. A relationship between task variables and parameters of a supervisory model is assumed. The model consists of three parts: (1) The observer part is thought to be a full order optimal observer, (2) the decision-making part is stated as a set of decision rules, and (3) the controller part is given by a control law. The observer part generates, on the basis of the system output and the control actions, an estimate of the state of the system and its associated variance. The outputs of the observer part are then used by the decision-making part to determine the instants in time of the observation actions on the one hand and the controls actions on the other. The controller part makes use of the estimated state to derive the amplitude(s) of the control action(s).

Performance of a surface bypass structure to enhance juvenile steelhead passage and survival at Lower Granite Dam, Washington

USGS Publications Warehouse

Adams, Noah S.; Plumb, John M.; Perry, Russell W.; Rondorf, Dennis W.

2014-01-01

An integral part of efforts to recover stocks of Pacific salmon Oncorhynchus spp. and steelhead O. mykiss in Pacific Northwest rivers is to increase passage efficacy and survival of juveniles past hydroelectric dams. As part of this effort, we evaluated the efficacy of a prototype surface bypass structure, the removable spillway weir (RSW), installed in a spillbay at Lower Granite Dam, Washington, on the Snake River during 2002, 2003, 2005, and 2006. Radio-tagged juvenile steelhead were released upstream from the dam and their route of passage through the turbines, juvenile bypass, spillway, or RSW was recorded. The RSW was operated in an on-or-off condition and passed 3–13% of the total discharge at the dam when it was on. Poisson rate models were fit to the passage counts of hatchery- and natural-origin juvenile steelhead to predict the probability of fish passing the dam. Main-effect predictor variables were RSW operation, diel period, day of the year, proportion of flow passed by the spillway, and total discharge at the dam. The combined fish passage through the RSW and spillway was 55–85% during the day and 37–61% during the night. The proportion of steelhead passing through nonturbine routes was <88% when the RSW was off during the day and increased to >95% when the RSW was on during the day. The ratio of the proportion of steelhead passed to the proportion of water passing the RSW was from 6.3:1 to 10.0:1 during the day and from 2.7:1 to 5.2:1 during the night. Steelhead passing through the RSW exited the tailrace about 15 min faster than fish passing through the spillway. Mark–recapture single-release survival estimates for steelhead passing the RSW ranged from 0.95 to 1.00. The RSW appeared to be an effective bypass structure compared with other routes of fish passage at the dam.

Comparison of GPM IMERG, TMPA 3B42 and PERSIANN-CDR satellite precipitation products over Malaysia

NASA Astrophysics Data System (ADS)

Tan, Mou Leong; Santo, Harrif

2018-04-01

The launch of the Global Precipitation Measurement (GPM) mission has prompted the assessment of the newly released satellite precipitation products (SPPs) in different parts of the world. This study performed an initial comparison of three GPM IMERG products (IMERG_E, IMERG_L and IMERG_F) with its predecessor, the TMPA 3B42 and 3B42RT products, and a long-term PERSIANN-CDR product over Malaysia. The performance of six SPPs was evaluated using 501 precipitation gauges from 12 March 2014 to 29 February 2016. The annual, seasonal, monthly and daily precipitation measurements were validated using three widely used statistical metrics (CC, RMSE and RB). The precipitation detection capability (POD, FAR and CSI), probability density function (PDF) and the 2014-2015 flood event analysis were also considered in this assessment. The results show that all the SPPs perform well in annual and monthly precipitation measurements. The spatial variability of the total annual precipitation in 2015 is well captured by all six SPPs, with high precipitation amount in southern East Malaysia, and low precipitation amount in the middle part of Peninsular Malaysia. In contrast, all the SPPs show moderate correlation at daily precipitation estimations, with better performance during the northeast monsoon season. The performance of all the SPPs is better in eastern Peninsular Malaysia, but poorer in northern Peninsular Malaysia. All the SPPs have good precipitation detection ability, except the PERSIANN-CDR. All the SPPs underestimate the light (0-1 mm/day) and violent (> 50 mm/day) precipitation classes, but overestimate moderate and heavy (1-50 mm/day) precipitation classes. The IMERG is shown to have a better capability in detecting light precipitation (0-1 mm/day) compared to the other SPPs. The PERSIANN-CDR has the worst performance in capturing all the precipitation classes, with significant underestimation of light precipitation (0-1 mm/day) class and overestimation of moderate and heavy precipitation classes. The IMERG near-real time products with finer temporal and spatial resolutions can be regarded as a reliable precipitation source in studying the 2014-2015 flood event in Malaysia.

Multiband Fourier Analysis and Interstellar Reddening of the Variable Stars in the Globular Cluster NGC 6402 (M14)

NASA Astrophysics Data System (ADS)

Weinschenk, Sedrick; Murphy, Brian; Villiger, Nathan J.

2018-01-01

We present a detailed study of the variable stars in the globular cluster NGC 6402 (M14). Approximately 1500 B and V band images were collected from July 2016 to August 2017 using the SARA Consortium Jacobus Kaptyen 1-meter telescope located in the Canary Islands. Using difference image analysis, we were able to identify 145 probable variable stars, confirming the 133 previously known variables and adding 12 new variables. The variables consisted of 117 RR Lyrae stars, 18 long period variables, 2 eclipsing variables, 6 Cepheid variables, and 2 SX Phoenix variables. Of the RR Lyrae variables 55 were of fundamental mode RR0 stars, of which 18 exhibited the Blazhko effect, 57 were of 1st overtone RR1, of which 7 appear to exhibit the Blazhko effect, 1 2nd overtone RR2, and 2 double mode variables. We found an average period of 0.59016 days for RR0 stars and 0.30294 days for RR1 stars. Using the multiband light curves of both the RR0 and RR1 variables we found an average E(B-V) of 0.604 with a scatter of 0.15 magnitudes. Using Fourier decomposition of the RR Lyrae light curves we also determined the metallicity and distance of the NGC 6402.

Minimum length of the adaptation and collection period in digestibility trials with sheep fed ad libitum only forage or forage plus concentrate.

PubMed

Farenzena, R; Kozloski, G V; Gindri, M; Stefanello, S

2017-10-01

Two in vivo digestibility trials with sheep were conducted to identify the minimum period length of feeding a new diet to obtain reproducible values of nutritional variables onward and the minimum length of collection period as to obtain maximal precision for each variable. Trial 1 was conducted with ten Polwarth male sheep (34 ± 5 kg body weight (BW)) throughout three 21-day periods, in a completely randomized two-way crossover design. The animals were divided into two groups (Group A and B, n = 5 per group) which were fed ad libitum with a sequence of the following diets throughout the periods: Group A: hay - hay plus concentrate - hay; Group B: hay plus concentrate - hay - hay plus concentrate. The concentrate was included in a proportion of 0.33 of the total diet. The intake, and the faecal and urinary excretion were measured daily throughout the experiment. For evaluating rumen fermentation variables, in Trial 2 four Santa Inês male sheep (65 ± 5 kg BW) fitted with ruminal cannula were used. The animals were randomly divided into two groups (n = 2 per group), and the trial was conducted through four 21 days experimental period, in a three-way crossover design, using experimental diets and feeding management similar to Trial 1. The results indicated that, even though no clear or consistent steady-state condition was identified for rumen fermentation or urinary excretion variables, the adaptation period for measuring OM digestibility in in vivo trials with sheep fed ad libitum where the diet shifts from one of only hay to another containing concentrate, or vice-versa, should be at least 12 days long. Moreover, although no precision improvement was obtained by increasing the collection period above 1 day for measuring OM digestibility, the minimal length of collection period should be 4 days for measuring faecal excretion variables and 7 days for measuring urinary excretion variables. Journal of Animal Physiology and Animal Nutrition © 2016 Blackwell Verlag GmbH.

Analysis of satellite precipitation over East Africa during last decades

NASA Astrophysics Data System (ADS)

Cattani, Elsa; Wenhaji Ndomeni, Claudine; Merino, Andrés; Levizzani, Vincenzo

2016-04-01

Daily accumulated precipitation time series from satellite retrieval algorithms (e.g., ARC2 and TAMSAT) are exploited to extract the spatial and temporal variability of East Africa (EA - 5°S-20°N, 28°E-52°E) precipitation during last decades (1983-2013). The Empirical Orthogonal Function (EOF) analysis is applied to precipitation time series to investigate the spatial and temporal variability in particular for October-November-December referred to as the short rain season. Moreover, the connection among EA's precipitation, sea surface temperature, and soil moisture is analyzed through the correlation with the dominant EOF modes of variability. Preliminary results concern the first two EOF's modes for the ARC2 data set. EOF1 is characterized by an inter-annual variability and a positive correlation between precipitation and El Niño, positive Indian Ocean Dipole mode, and soil moisture, while EOF2 shows a dipole structure of spatial variability associated with a longer scale temporal variability. This second dominant mode is mostly linked to sea surface temperature variations in the North Atlantic Ocean. Further analyses are carried out by computing the time series of the joint CCI/CLIVAR/JCOMM Expert Team on Climate Change Detection and Indices (ETCCDI, http://etccdi.pacificclimate.org/index.shtml), i.e. RX1day, RX5day, CDD, CDD, CWD, SDII, PRCPTOT, R10, R20. The purpose is to identify the occurrenes of extreme events (droughts and floods) and extract precipitation temporal variation by trend analysis (Mann-Kendall technique). Results for the ARC2 data set demonstrate the existence of a dipole spatial pattern in the linear trend of the time series of PRCPTOT (annual precipitation considering days with a rain rate > 1 mm) and SDII (average precipitation on wet days over a year). A negative trend is mainly present over West Ethiopia and Sudan, whereas a positive trend is exhibited over East Ethiopia and Somalia. CDD (maximum number of consecutive dry days) and CWD (maximum number of consecutive wet days) time series do not exhibit a similar behavior and trends are generally weaker with a lower significance level with respect to PRCPTOT and SDII.

Predictors of 30-day readmission following pancreatic surgery: A retrospective review.

PubMed

Amodu, Leo I; Alexis, Jamil; Soleiman, Aron; Akerman, Meredith; Addison, Poppy; Iurcotta, Toni; Rilo, Horacio L Rodriguez

2018-06-01

Pancreatectomies have been identified as procedures with an increased risk of readmission. In surgical patients, readmissions within 30 days of discharge are usually procedure-related. We sought to determine predictors of 30-day readmission following pancreatic resections in a large healthcare system. We retrospectively collected information from the records of 383 patients who underwent pancreatic resections from 2004-2013. To find the predictors of readmission in the 30 days after discharge, we performed a univariate screen of possible variables using the Fisher's exact test for categorical variables and the Mann-Whitney U test for continuous variables. Multivariate analysis was used to determine the independent factors. Fifty-eight (15.1%) patients were readmitted within 30 days of discharge. Of the patients readmitted, the most common diagnoses at readmission were sepsis (17.2%), and dehydration (8.6%). Multivariate logistic regression found that the development of intra-abdominal fluid collections (OR = 5.32, P < 0.0001), new thromboembolic events (OR = 4.08, P = 0.016), and pre-operative BMI (OR = 1.06, P = 0.040) were independent risk factors of readmission within 30 days of discharge. Our data demonstrate that factors predictive of 30-day readmission are a combination of patient characteristics and the development of post-operative complications. Targeted interventions may be used to reduce the risk of readmission. Copyright © 2018. Published by Elsevier B.V.

Validity of Monod kinetics at different sludge ages--peptone biodegradation under aerobic conditions.

PubMed

Orhon, Derin; Cokgor, Emine Ubay; Insel, Guclu; Karahan, Ozlem; Katipoglu, Tugce

2009-12-01

The study presented an evaluation of the effect of culture history (sludge age) on the growth kinetics of a mixed culture grown under aerobic conditions. It involved an experimental setup where a lab-scale sequencing batch reactor was operated at steady-state at two different sludge ages (theta(X)) of 2 and 10 days. The system sustained a mixed culture fed with a synthetic substrate mainly consisting of peptone. The initial concentration of substrate COD was selected around 500 mg COD/L. Polyhydroxyalkanoate (PHA) storage occurred to a limited extent, around 30 mg COD/L for theta(X)=10 days and 15 mg COD/L for theta(X)=2 days. Evaluation of the experimental data based on calibration of two different models provided consistent and reliable evidence for a variable Monod kinetics where the maximum specific growth rate, was assessed as 6.1/day for theta(X)=2 days and 4.1/day for theta(X)=10 days. A similar variability was also applicable for the hydrolysis and storage kinetics. The rate of storage was significantly lower than the levels reported in the literature, exhibiting the ability of the microorganisms to regulate their metabolic mechanisms for adjusting the rate of microbial growth and storage competing for the same substrate. This adjustment evidently resulted in case-specific, variable kinetics both for microbial growth and substrate storage.

Trends and changes in tropical and summer days at the Adana Sub-Region of the Mediterranean Region, Southern Turkey

NASA Astrophysics Data System (ADS)

Bayer Altın, Türkan; Barak, Belma

2017-11-01

In this study, the long-term variability and trends of the annual and seasonal numbers of summer and tropical days of the Adana Sub-region were investigated using nonlinear and linear trend detection tests for the period 1960-2014 at 14 meteorological stations. The results suggest that the annual number of summer and tropical days was generally below the long-term average through to the end of the 1980s. In particular, positive anomaly values could be observed at all stations between the years 1993-2014. With respect to the Kruskal-Wallis homogeneity test, the significant breaking date was 1993. The rapid rise of the annual number of summer (tropical) days after this year led to the inversion of the negative trends observed from 1987 to 1992 into positive ones. The increasing trend is statistically significance at 0.01 level in Yumurtalık, Mersin and Antakya for the annual number of summer and tropical days. Dörtyol, İskenderun and Elbistan were significance at 0.01 level for tropical days. The largest positive anomalies of the summer of 2010 are observed in coastal vicinity (Mersin, Yumurtalık and İskenderun). This indicates that these settlements underwent a long-term warm period and thermal conditions due to increasing temperatures in the spring and summer months. The same conditions are found in high inner areas (Göksun and Elbistan) for tropical days. It is noticed that a tendency for greater warming occurred at stations located above 1000 m in the sub-region. The average number of warm days will increase 2-days per 100-years in southern part of the sub-region. The increasing trend in summer temperatures can be considered a potential risk, notably for human health and for economic and crop losses in the Adana Sub-region, including Çukurova, one of the most important agriculture areas of Turkey.

The periodicities in and biometeorological relationships with bed occupancy of an acute psychiatric ward in Antwerp, Belgium

NASA Astrophysics Data System (ADS)

Maes, M.; de Meyer, F.; Peeters, D.; Meltzer, H.; Schotte, C.; Scharpe, S.; Cosyns, P.

1993-06-01

Recently, some investigators have established a seasonal pattern in normal human psychology, physiology and behaviour, and in the incidence of psychiatric psychopathology. In an attempt to elucidate the chronopsy and meteotropism in the latter, we have examined the chronograms of, and the biometeorological relationships to bed occupancy of the psychiatric ward of the Antwerp University Hospital during three consecutive calendar years (1987 1989). Weather data for the vicinity were provided by a local meteorological station and comprise mean atmospheric pressure, air temperature, relative humidity, wind speed and minutes of sunlight and precipitation/day. The number of psychiatric beds occupied during the study period exhibited a significant seasonal variation. Peaks in bed occupancy were observed in March and November, with lows in August. An important part of the variability in the number of beds occupied could be explained by the composite effects of weather variables of the preceding weeks. Our results suggest that short-term fluctuations in atmospheric activity may dictate some of the periodicities in psychiatric psychopathology.

Modeling groundwater flow and quality

USGS Publications Warehouse

Konikow, Leonard F.; Glynn, Pierre D.; Selinus, Olle

2013-01-01

In most areas, rocks in the subsurface are saturated with water at relatively shallow depths. The top of the saturated zone—the water table—typically occurs anywhere from just below land surface to hundreds of feet below the land surface. Groundwater generally fills all pore spaces below the water table and is part of a continuous dynamic flow system, in which the fluid is moving at velocities ranging from feet per millennia to feet per day (Fig. 33.1). While the water is in close contact with the surfaces of various minerals in the rock material, geochemical interactions between the water and the rock can affect the chemical quality of the water, including pH, dissolved solids composition, and trace-elements content. Thus, flowing groundwater is a major mechanism for the transport of chemicals from buried rocks to the accessible environment, as well as a major pathway from rocks to human exposure and consumption. Because the mineral composition of rocks is highly variable, as is the solubility of various minerals, the human-health effects of groundwater consumption will be highly variable.

Improving Seasonal Crop Monitoring and Forecasting for Soybean and Corn in Iowa

NASA Astrophysics Data System (ADS)

Togliatti, K.; Archontoulis, S.; Dietzel, R.; VanLoocke, A.

2016-12-01

Accurately forecasting crop yield in advance of harvest could greatly benefit farmers, however few evaluations have been conducted to determine the effectiveness of forecasting methods. We tested one such method that used a combination of short-term weather forecasting from the Weather Research and Forecasting Model (WRF) to predict in season weather variables, such as, maximum and minimum temperature, precipitation and radiation at 4 different forecast lengths (2 weeks, 1 week, 3 days, and 0 days). This forecasted weather data along with the current and historic (previous 35 years) data from the Iowa Environmental Mesonet was combined to drive Agricultural Production Systems sIMulator (APSIM) simulations to forecast soybean and corn yields in 2015 and 2016. The goal of this study is to find the forecast length that reduces the variability of simulated yield predictions while also increasing the accuracy of those predictions. APSIM simulations of crop variables were evaluated against bi-weekly field measurements of phenology, biomass, and leaf area index from early and late planted soybean plots located at the Agricultural Engineering and Agronomy Research Farm in central Iowa as well as the Northwest Research Farm in northwestern Iowa. WRF model predictions were evaluated against observed weather data collected at the experimental fields. Maximum temperature was the most accurately predicted variable, followed by minimum temperature and radiation, and precipitation was least accurate according to RMSE values and the number of days that were forecasted within a 20% error of the observed weather. Our analysis indicated that for the majority of months in the growing season the 3 day forecast performed the best. The 1 week forecast came in second and the 2 week forecast was the least accurate for the majority of months. Preliminary results for yield indicate that the 2 week forecast is the least variable of the forecast lengths, however it also is the least accurate. The 3 day and 1 week forecast have a better accuracy, with an increase in variability.

Development of Milestone Schedules for Selected Logistics Support Directorate Programs. Appendix A. Part 2. Task Summaries.

DTIC Science & Technology

1987-09-15

MAC; CODE NUMBER: NONE AND REPAIR PARTS AND SPECIAL TOOLS LIST (RPSTL). RESPONSIBILITY: ROY & ILS DURATION: 32.00 WORK DAYS PRE PPPL SCHEDULE...ILS DURATION: 22.00 WORK DAYS R/V PPPL SCHEDULE: DVPMARPS REVIEW AND VALIDATE PRELIMINARY PROVISIONING PARTS LIST. CODE NUMBER: NONE RESPONSIBILITY

Impact of geriatric assessment variables on 30-day mortality among older patients with acute heart failure.

PubMed

Martín-Sánchez, Francisco Javier; Rodríguez-Adrada, Esther; Vidán, María Teresa; Díez Villanueva, Pablo; Llopis García, Guillermo; González Del Castillo, Juan; Alberto Rizzi, Miguel; Alquézar, Aitor; Herrera Mateo, Sergio; Piñera, Pascual; Sánchez Nicolás, José Andrés; Lázaro Aragues, Paula; Llorens, Pere; Herrero, Pablo; Jacob, Javier; Gil, Víctor; Fernández, Cristina; Bueno, Héctor; Miró, Òscar

2018-06-01

To study the impact of geriatric assessment variables on 30-day mortality among older patients with acute heart failure (AHF). Retrospective analysis of cases in the OAK Registry (Older Acute Heart Failure Key Data), a prospectively compiled database of consecutive patients aged 65 years or older treated for AHF in 3 Spanish emergency departments over a 4-month period (November-December 2011 and January-February 2014). The patients underwent a geriatric assessment adapted for emergency department use on weekdays between 8 AM and 10 PM. Demographic, clinical, laboratory, and geriatric assessment variables were recorded. The geriatric variables were concurrent diseases; polypharmacy; frailty; functional, social, and cognitive status at baseline; results of screening for confusional state, cognitive impairment, and depression; and nutritional status. The primary outcome was all-cause mortality at 30 days. We included 565 patients with a mean (SD) age of 83 (7.1) years; 346 (61.6%) were women. Sixty-five (11.5%) died within 30 days. Independent factors associated with 30-day mortality were acute confusional state (adjusted odds ratio [aOR], 2.2; 95% CI, 1.0–4.8; P=.04), acute illness (aOR, 1.8; 95% CI, 0.9–3.4; P=.05), loss of appetite in the past 3 months (aOR, 1.8; 95% CI, 1.0–3.4; P=.04), frailty (aOR, 2.0, 95% CI, 1.0–4.1; P=.05), and severe disability (aOR, 4.4; 95% CI, 1.9–11.4; P=.01). Certain geriatric variables should be considered when assessing short-term risk in older patients with AHF.

Seasonally adjusted birth frequencies follow the Poisson distribution.

PubMed

Barra, Mathias; Lindstrøm, Jonas C; Adams, Samantha S; Augestad, Liv A

2015-12-15

Variations in birth frequencies have an impact on activity planning in maternity wards. Previous studies of this phenomenon have commonly included elective births. A Danish study of spontaneous births found that birth frequencies were well modelled by a Poisson process. Somewhat unexpectedly, there were also weekly variations in the frequency of spontaneous births. Another study claimed that birth frequencies follow the Benford distribution. Our objective was to test these results. We analysed 50,017 spontaneous births at Akershus University Hospital in the period 1999-2014. To investigate the Poisson distribution of these births, we plotted their variance over a sliding average. We specified various Poisson regression models, with the number of births on a given day as the outcome variable. The explanatory variables included various combinations of years, months, days of the week and the digit sum of the date. The relationship between the variance and the average fits well with an underlying Poisson process. A Benford distribution was disproved by a goodness-of-fit test (p < 0.01). The fundamental model with year and month as explanatory variables is significantly improved (p < 0.001) by adding day of the week as an explanatory variable. Altogether 7.5% more children are born on Tuesdays than on Sundays. The digit sum of the date is non-significant as an explanatory variable (p = 0.23), nor does it increase the explained variance. INERPRETATION: Spontaneous births are well modelled by a time-dependent Poisson process when monthly and day-of-the-week variation is included. The frequency is highest in summer towards June and July, Friday and Tuesday stand out as particularly busy days, and the activity level is at its lowest during weekends.

A VLA (Very Large Array) Search for 5 GHz Radio Transients and Variables at Low Galactic Latitudes

NASA Technical Reports Server (NTRS)

Ofek, E. O.; Frail, D. A.; Breslauer, B.; Kulkarni, S. R.; Chandra, P.; Gal-Yam, A.; Kasliwal, M. M.; Gehrels, N.

2012-01-01

We present the results of a 5GHz survey with the Very Large Array (VLA) and the expanded VLA, designed to search for short-lived (approx < 1 day) transients and to characterize the variability of radio sources at milli-Jansky levels. A total sky area of 2.66 sq. deg, spread over 141 fields at low Galactic latitudes (b approx equals 6 - 8 deg) was observed 16 times with a cadence that was chosen to sample timescales of days, months and years. Most of the data were reduced, analyzed and searched for transients in near real time. Interesting candidates were followed up using visible light telescopes (typical delays of 1 - 2 hr) and the X-Ray Telescope on board the Swift satellite. The final processing of the data revealed a single possible transient with a flux density of f(sub v) approx equals 2.4mJy. This implies a transients sky surface density of kappa(f(sub v) > 1.8mJy) = 0.039(exp +0.13,+0.18) (sub .0.032,.0.038) / sq. deg (1, 2 sigma confidence errors). This areal density is consistent with the sky surface density of transients from the Bower et al. survey extrapolated to 1.8mJy. Our observed transient areal density is consistent with a Neutron Stars (NSs) origin for these events. Furthermore, we use the data to measure the sources variability on days to years time scales, and we present the variability structure function of 5GHz sources. The mean structure function shows a fast increase on approximately 1 day time scale, followed by a slower increase on time scales of up to 10 days. On time scales between 10 - 60 days the structure function is roughly constant. We find that approx > 30% of the unresolved sources brighter than 1.8mJy are variable at the > 4-sigma confidence level, presumably due mainly to refractive scintillation.

Depressive symptoms in Chinese factory workers in Nagasaki, Japan.

PubMed

Date, Yutaka; Abe, Yasuyo; Aoyagi, Kiyoshi; Ye, Zhaojia; Takamura, Noboru; Tomita, Masato; Osaki, Makoto; Honda, Sumihisa

2009-08-01

The number of foreign workers in Japan, especially temporary workers, has been increasing recently. However, little is known about the mental health status of the foreign workers working temporarily in Japan. We examined the depressive symptoms in 81 Chinese factory workers and attempted to identify the determining factors. The subjects were requested to complete individual questionnaires on sociodemographic variables (sex, age group, and residence period in Japan), working condition variables (number of working days per week and working hours per day), health administration variables (health checkups and health education), a social support variable (interpreters at workplace), and health behavior variables (alcohol consumption, current smoking, and regular exercise). The 20-item Center for Epidemiologic Studies Depression scale (CES-D) was used to measure the depressive symptoms. Of all the subjects, 95% and 84% received health checkups and health education, respectively, at their workplaces. The results of multiple linear regression analysis showed that long working hours per day were significantly associated with high CES-D score. Further, we found that older age (30-49 yr) was marginally associated with high CES-D score. Health administration considering working time and age would be important for decreasing depressive symptoms among foreign workers.

The Effect of Experimental Variables on Industrial X-Ray Micro-Computed Sensitivity

NASA Technical Reports Server (NTRS)

Roth, Don J.; Rauser, Richard W.

2014-01-01

A study was performed on the effect of experimental variables on radiographic sensitivity (image quality) in x-ray micro-computed tomography images for a high density thin wall metallic cylinder containing micro-EDM holes. Image quality was evaluated in terms of signal-to-noise ratio, flaw detectability, and feature sharpness. The variables included: day-to-day reproducibility, current, integration time, voltage, filtering, number of frame averages, number of projection views, beam width, effective object radius, binning, orientation of sample, acquisition angle range (180deg to 360deg), and directional versus transmission tube.

Tracing temperature patterns of cut leafy greens during service in North Carolina school food service.

PubMed

Thomas, Ellen M; Chapman, Benjamin; Jaykus, Lee-Ann; Phister, Trevor

2014-09-01

Contaminated fresh produce has been increasingly identified as a cause of foodborne illnesses. Because of concerns about pathogen growth on these food items at retail, the 2009 U.S. Food and Drug Administration Food Code established that cut leafy greens (lettuce, spinach, spring mix, cabbage, arugula, and kale) must have time and temperature controls for safety and hence should be kept at refrigerated temperatures (5°C or lower). The purpose of this study was to determine the temperature profiles of cut leafy greens in single-serving clamshell containers provided as part of the North Carolina School Lunch Program and to compare the two policies that North Carolina has in place to control the temperature of these products (the 3-day rule and time in lieu of temperature). Temperatures were recorded with data loggers in 24 schools during a 3-day period. In all cases, substantial temperature variability was found for these products, including temperatures above 5°C for at least 1 h on each of the 3 days. In some cases, temperatures reached above 5°C for more than 3 h throughout the serving time. The results demonstrate the importance of developing a protocol for continuous temperature monitoring of leafy greens served in school lunch programs.

Acute and subchronic effects of bilastine (20 and 40 mg) and hydroxyzine (50 mg) on actual driving performance in healthy volunteers.

PubMed

Conen, Silke; Theunissen, Eef L; Van Oers, Anita C M; Valiente, Román; Ramaekers, Johannes G

2011-11-01

Bilastine is a new second-generation H1 antagonist. Although bilastine has been demonstrated to produce little or no performance impairment in laboratory tests, it cannot be excluded that it produces impairments in real-life performance such as driving. This study aims to assess the effects of two doses of bilastine (20 and 40 mg) on actual driving after single and repeated administration. Hydroxyzine 50 mg was included as an active control. Twenty-two participants (11 females, 11 males) were tested in a placebo-controlled, randomized, double-blind, four-way cross-over design. Participants were treated with once-daily doses for eight consecutive days. On day 1 and 8 of each treatment period participants performed an actual highway driving test. The primary variable was standard deviation of lateral position (SDLP), a measure of weaving. Results demonstrated that hydroxyzine significantly increased SDLP on days 1 and 8 of treatment. Bilastine did not affect SDLP. It is concluded that hydroxyzine produces severe driving impairment after single doses and that this impairment only partly mitigates over time due to a lack of complete tolerance. Bilastine did not produce any driving impairment after single and repeated doses and can be safely used in traffic in doses up to 40 mg.

The IUE Mega Campaign. Modulated Structure in the Wind of HD 64760 (B0.5 Ib)

NASA Technical Reports Server (NTRS)

Prinja, Raman K.; Massa, Derck; Fullerton, Alexander W.

1995-01-01

We highlight systematic variability in the stellar wind of the early B type supergiant, HD 64760, whose UV line profiles were monitored for almost 16 days in 1995 January as part of the IUE 'MEGA Campaign.' The extensive coverage reveals a pattern of rapidly evolving discrete optical depth changes which typically migrate from approx. - 200 km/s to approx. -1500 km/s in less than 12 hr. These features coexist with more slowly evolving structures lasting several days. Time-series analysis of the Si(IV), Si(III), and N(V) profile variations presents a clear 1.2 day periodicity, which is a quarter of the estimated maximum rotation period of HD 64760. The line profile changes are consistent with an interpretation in terms of a set of corotating wind features which occult the stellar disk at least 3 times during the observing run. These data are combined with UV observations collected in 1993 March to argue in favor of rotationally modulated wind variations in HD 64760. The basic result of very regular, large-scale optical depth variations points to a 'clock' whose origin is on the stellar surface, rather than a mechanism that is entirely intrinsic to the stellar wind.

Incubation behavior of Spectacled Eiders on the Yukon-Kuskokwim Delta, Alaska

USGS Publications Warehouse

Flint, Paul L.; Grand, J.B.

1999-01-01

We studied incubation behavior of Spectacled Eiders (Somateria fischeri) on the Yukon-Kuskokwim Delta in 1996. We trapped 19 females on their nests and weighed them in early incubation and again at hatch. Average daily weight loss for incubating females was 16.6 ?? 1.0 g day-1, which resulted in a cumulative loss of 26% of body weight throughout incubation. Nest attendance was monitored for a portion of the incubation period using temperature sensing artificial eggs. Incubation constancy averaged 90 ?? 1%. Average recess length was 37.1 ?? 0.9 min, and nests cooled an average of 4.2 ?? 0.1??C during recesses. Recess frequency averaged 2.5 ?? 0.1 recesses day-1, and most recesses (70%) occurred between 10:00 and 22: 00. Incubation constancy varied among females, but was not related to changes in body weight or incubation period. There was no influence of ambient temperature on incubation recess length, however most recesses were taken during the warmest part of the day. We found considerable variation among females in patterns of daily incubation constancy, nest cooling, recess frequency, and recess length. It is not clear from our results what factors constrain incubation behavior of Spectacled Eiders, but we suggest that individual females respond to a complex suite of variables.

Two Cepheid variables in the Fornax dwarf galaxy

NASA Technical Reports Server (NTRS)

Light, R. M.; Armandroff, T. E.; Zinn, R.

1986-01-01

Two fields surrounding globular clusters 2 and 3 in the Fornax dwarf spheroidal galaxy have been searched for short-period variable stars that are brighter than the horizontal branch. This survey confirmed as variable the two suspected suprahorizontal-branch variables discovered by Buonanno et al. (1985) in their photometry of the clusters. The observations show that the star in cluster 2 is a W Virginis variable of 14.4 day period. It is the first W Vir variable to be found in a dwarf spheroidal galaxy, and its proximity to the center of cluster 2 suggests that it is a cluster member. The other star appears to be an anomalous Cephpeid of 0.78 day period. It lies outside or very near the boundary of cluster 3, and is therefore probably a member of the field population of Fornax. Although no other suprahorizontal-branch variables were discovered in the survey, it did confirm as variable two of the RR Lyrae candidates of Buonanno et al., which appeared at the survey limit. The implications of these observations for the understanding of the stellar content at Fornax are discussed.

34 CFR 300.11 - Day; business day; school day.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true Day; business day; school day. 300.11 Section 300.11... CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.11 Day; business day; school day. (a) Day means calendar day unless otherwise indicated as business day or school day. (b) Business day...

Impact of Dual Use of Department of Veterans Affairs and Medicare Part D Drug Benefits on Potentially Unsafe Opioid Use.

PubMed

Gellad, Walid F; Thorpe, Joshua M; Zhao, Xinhua; Thorpe, Carolyn T; Sileanu, Florentina E; Cashy, John P; Hale, Jennifer A; Mor, Maria K; Radomski, Thomas R; Hausmann, Leslie R M; Donohue, Julie M; Gordon, Adam J; Suda, Katie J; Stroupe, Kevin T; Hanlon, Joseph T; Cunningham, Francesca E; Good, Chester B; Fine, Michael J

2018-02-01

To estimate the prevalence and consequences of receiving prescription opioids from both the Department of Veterans Affairs (VA) and Medicare Part D. Among US veterans enrolled in both VA and Part D filling 1 or more opioid prescriptions in 2012 (n = 539 473), we calculated 3 opioid safety measures using morphine milligram equivalents (MME): (1) proportion receiving greater than 100 MME for 1 or more days, (2) mean days receiving greater than 100 MME, and (3) proportion receiving greater than 120 MME for 90 consecutive days. We compared these measures by opioid source. Overall, 135 643 (25.1%) veterans received opioids from VA only, 332 630 (61.7%) from Part D only, and 71 200 (13.2%) from both. The dual-use group was more likely than the VA-only group to receive greater than 100 MME for 1 or more days (34.3% vs 10.9%; adjusted risk ratio [ARR] = 3.0; 95% confidence interval [CI] = 2.9, 3.1), have more days with greater than 100 MME (42.5 vs 16.9 days; adjusted difference = 16.4 days; 95% CI = 15.7, 17.2), and to receive greater than 120 MME for 90 consecutive days (7.8% vs 3.1%; ARR = 2.2; 95% CI = 2.1, 2.3). Among veterans dually enrolled in VA and Medicare Part D, dual use of opioids was associated with more than 2 to 3 times the risk of high-dose opioid exposure.

The Analytic Information Warehouse (AIW): a Platform for Analytics using Electronic Health Record Data

PubMed Central

Post, Andrew R.; Kurc, Tahsin; Cholleti, Sharath; Gao, Jingjing; Lin, Xia; Bornstein, William; Cantrell, Dedra; Levine, David; Hohmann, Sam; Saltz, Joel H.

2013-01-01

Objective To create an analytics platform for specifying and detecting clinical phenotypes and other derived variables in electronic health record (EHR) data for quality improvement investigations. Materials and Methods We have developed an architecture for an Analytic Information Warehouse (AIW). It supports transforming data represented in different physical schemas into a common data model, specifying derived variables in terms of the common model to enable their reuse, computing derived variables while enforcing invariants and ensuring correctness and consistency of data transformations, long-term curation of derived data, and export of derived data into standard analysis tools. It includes software that implements these features and a computing environment that enables secure high-performance access to and processing of large datasets extracted from EHRs. Results We have implemented and deployed the architecture in production locally. The software is available as open source. We have used it as part of hospital operations in a project to reduce rates of hospital readmission within 30 days. The project examined the association of over 100 derived variables representing disease and co-morbidity phenotypes with readmissions in five years of data from our institution’s clinical data warehouse and the UHC Clinical Database (CDB). The CDB contains administrative data from over 200 hospitals that are in academic medical centers or affiliated with such centers. Discussion and Conclusion A widely available platform for managing and detecting phenotypes in EHR data could accelerate the use of such data in quality improvement and comparative effectiveness studies. PMID:23402960

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baek, Giseon; Pak, Soojong; Lee, Jeong-Eun

We carried out photometric observations for HBC 722 in the Sloan Digital Sky Survey r, i, and z bands from 2011 April to 2013 May with the Camera for QUasars in EArly uNiverse attached to the 2.1 m Otto Struve telescope at McDonald Observatory. The post-outburst phenomena were classified into five phases according to not only brightness but also color variations, which might be caused by physical changes in the emitting regions of optical and near-infrared bands. A series of spectral energy distributions (SEDs) is presented to support color variations and track the time evolution of the SED in optical/near-infraredmore » bands after the outburst. Given two years of data, possible periodicities of r, i, and z bands were checked. We found three families of signals around ∼6, ∼10, and ∼1 days in three bands, which is broadly consistent with Green et al. We also examined short-term variability (intra-day and day scales) to search for evidences of flickering by using the micro-variability method. We found clear signs of day scale variability and weak indications of intra-day scale fluctuations, which implies that the flickering event occurs in HBC 722 after outburst.« less

Time to rehabilitation in the burn population: incidence of zero onset days in the UDSMR national dataset.

PubMed

Schneider, Jeffrey C; Tan, Wei-Han; Goldstein, Richard; Mix, Jacqueline M; Niewczyk, Paulette; Divita, Margaret A; Ryan, Colleen M; Gerrard, Paul B; Kowalske, Karen; Zafonte, Ross

2013-01-01

A preliminary investigation of the burn rehabilitation population found a large variability of zero onset day frequency between facilities. Onset days is defined as the time from injury to inpatient rehabilitation admission; this variable has not been investigated in burn patients previously. This study explored if this finding was a facility-based phenomena or characteristic of burn inpatient rehabilitation patients. This study was a secondary analysis of Uniform Data System for Medical Rehabilitation (UDSmr) data from 2002 to 2007 examining inpatient rehabilitation characteristics among patients with burn injuries. Exclusion criteria were age less than 18 years and discharge against medical advice. Comparisons of demographic, medical and functional data were made between facilities with a high frequency of zero onset days versus facilities with a low frequency of zero onset days. A total of 4738 patients from 455 inpatient rehabilitation facilities were included. Twenty-three percent of the population exhibited zero onset days (n = 1103). Sixteen facilities contained zero onset patients; two facilities accounted for 97% of the zero onset subgroup. Facilities with a high frequency of zero onset day patients demonstrated significant differences in demographic, medical, and functional variables compared to the remainder of the study population. There were significantly more zero onset day admissions among burn patients (23%) than other diagnostic groups (0.5- 3.6%) in the Uniform Data System for Medical Rehabilitation database, but the majority (97%) came from two inpatient rehabilitation facilities. It is unexpected for patients with significant burn injury to be admitted to a rehabilitation facility on the day of injury. Future studies investigating burn rehabilitation outcomes using the Uniform Data System for Medical Rehabilitation database should exclude facilities with a high percentage of zero onset days, which are not representative of the burn inpatient rehabilitation population.

Response Variability in Commercial MOSFET SEE Qualification

DOE PAGES

George, J. S.; Clymer, D. A.; Turflinger, T. L.; ...

2016-12-01

Single-event effects (SEE) evaluation of five different part types of next generation, commercial trench MOSFETs indicates large part-to-part variation in determining a safe operating area (SOA) for drain-source voltage (V DS) following a test campaign that exposed >50 samples per part type to heavy ions. These results suggest a determination of a SOA using small sample sizes may fail to capture the full extent of the part-to-part variability. An example method is discussed for establishing a Safe Operating Area using a one-sided statistical tolerance limit based on the number of test samples. Finally, burn-in is shown to be a criticalmore » factor in reducing part-to-part variation in part response. Implications for radiation qualification requirements are also explored.« less

Response Variability in Commercial MOSFET SEE Qualification

DOE Office of Scientific and Technical Information (OSTI.GOV)

George, J. S.; Clymer, D. A.; Turflinger, T. L.

Single-event effects (SEE) evaluation of five different part types of next generation, commercial trench MOSFETs indicates large part-to-part variation in determining a safe operating area (SOA) for drain-source voltage (V DS) following a test campaign that exposed >50 samples per part type to heavy ions. These results suggest a determination of a SOA using small sample sizes may fail to capture the full extent of the part-to-part variability. An example method is discussed for establishing a Safe Operating Area using a one-sided statistical tolerance limit based on the number of test samples. Finally, burn-in is shown to be a criticalmore » factor in reducing part-to-part variation in part response. Implications for radiation qualification requirements are also explored.« less

Part 1: Vadose-zone column studies of toluene (enhanced bioremediation) in a shallow unconfined aquifer

USGS Publications Warehouse

Tindall, J.A.; Friedel, M.J.; Szmajter, R.J.; Cuffin, S.M.

2005-01-01

The objectives of the laboratory study described in this paper were (1) to determine the effectiveness of four nutrient solutions and a control in stimulating the microbial degradation of toluene in the unsaturated zone as an alternative to bioremediation methodologies such as air sparging, in situ vitrification, or others (Part I), and (2) to compare the effectiveness of the addition of the most effective nutrient solution from Part I (modified Hoagland type, nitrate-rich) and hydrogen peroxide (H2O2) on microbial degradation of toluene for repeated, simulated spills in the unsaturated zone (Part II). For Part 1, fifteen columns (30-cm diameter by 150-cm height), packed with air-dried, 0.25-mm, medium-fine sand, were prepared to simulate shallow unconfined aquifer conditions. Toluene (10 mL) was added to the surface of each column, and soil solution and soil gas samples were collected from the columns every third day for 21 days. On day 21, a second application of toluene (10 mL) was made, and the experiment was run for another 21 days. Solution 4 was the most effective for microbial degradation in Part I. For Part II, three columns were designated nutrient-rich 3-day toluene columns and received toluene injections every 3 days; three columns were designated as nutrient-rich 7-day columns and received toluene injections every 7 days; and two columns were used as controls to which no nutrient was added. As measured by CO2 respiration, the initial benefits for aerobic organisms from the O2 enhancement were sustained by the bacteria for only a short period of time (about 8 days). Degradation benefits from the nutrient solution were sustained throughout the experiment. The O2 and nutrient-enhanced columns degraded significantly more toluene than the control columns when simulating repeated spills onto the unsaturated zone, and demonstrated a potentially effective in situ bioremediation technology when used immediately or within days after a spill. The combined usage of H 2O2 and nitrate-rich nutrients served to effectively maximize natural aerobic and anaerobic metabolic processes that biodegrade hydrocarbons in petroleum-contaminated media. Applications of this technology in the field may offer economical advantages to other, more intrusive abatement technologies. ?? Springer 2005.

Mapping the Riverscape of the Middle Fork John Day River with Structure-from-Motion

NASA Astrophysics Data System (ADS)

Dietrich, J. T.

2014-12-01

Aerial photography has proven an efficient method to collect a wide range of continuous variables for large sections of rivers. These data include variables such as the planimetric shape, low-flow and bank-full widths, bathymetry, and sediment sizes. Mapping these variables in a continuous manner allows us to explore the heterogeneity of the river and build a more complete picture of the holistic riverscape. To explore a low-cost option for aerial photography and riverscape mapping, I used the combination of a piloted helicopter and an off-the-shelf digital SLR camera to collect aerial imagery for a 32 km segment of the Middle Fork John Day River in eastern Oregon. This imagery was processed with Structure-from-Motion (SfM) photogrammetry to produce high-resolution 10 cm orthophotos and digital surface models that were used to extract riverscape variables. The Middle Fork John Day River is an important spawning river for anadromous Chinnook and Steelhead and has been the focus of widespread restoration and conservation activities in response to the legacies of extensive grazing and mining activity. By mapping the riverscape of the Middle Fork John Day, I explored downstream relationships between several geomorphic variables with hyperscale analysis. These riverscape data also provided an opportunity to make a continuous map of habitat suitability for migrating adult Chinook. Both the geomorphic and habitat suitability analysis provide an important assessment of the natural variation in the river and the impact of human modification, both positive and negative.

Chronic inflammatory demyelinating polyneuropathy in children: a report of four patients with variable relapsing courses

PubMed Central

Chang, Soo Jin; Lee, Ji Hyun; Kim, Shin Hye; Lee, Joon Soo; Kim, Heung Dong; Kang, Joon Won; Lee, Young Mock

2015-01-01

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronically progressive or relapsing symmetric sensorimotor disorder presumed to occur because of immunologic antibody-mediated reactions. To understand the clinical courses of CIDP, we report variable CIDP courses in children with respect to initial presentation, responsiveness to medical treatment, and recurrence interval. Four patients who were diagnosed with acute-onset and relapsing CIDP courses at Severance Children's Hospital, Seoul, Korea, were enrolled in this retrospective study. We diagnosed each patient on the basis of the CIDP diagnostic criteria developed in 2010 by the European Federation of Neurological Societies/Peripheral Nerve Society Guidelines. We present the cases of four pediatric patients diagnosed with CIDP to understand the variable clinical course of the disease in children. Our four patients were all between 8 and 12 years of age. Patients 1 and 2 were diagnosed with acute cerebellar ataxia or Guillain-Barré syndrome as initial symptoms. While patients 1 and 4 were given only intravenous dexamethasone (0.3 mg/kg/day) for 5 days at the first episode, Patients 2 and 3 were given a combination of intravenous immunoglobulin (2 g/kg) and dexamethasone (0.3 mg/kg/day). All patients were maintained with oral prednisolone at 30 mg/day, but their clinical courses were variable in both relapse intervals and severity. We experienced variable clinical courses of CIDP in children with respect to initial presentation, responsiveness to medical treatment, and recurrence interval. PMID:26124851

Spatial Variability in Biodegradation Rates as Evidenced by Methane Production from an Aquifer

PubMed Central

Adrian, Neal R.; Robinson, Joseph A.; Suflita, Joseph M.

1994-01-01

Accurate predictions of carbon and energy cycling rates in the environment depend on sampling frequencies and on the spatial variability associated with biological activities. We examined the variability associated with anaerobic biodegradation rates at two sites in an alluvial sand aquifer polluted by municipal landfill leachate. In situ rates of methane production were measured for almost a year, using anaerobic wells installed at two sites. Methane production ranged from 0 to 560 μmol · m-2 · day-1 at one site (A), while a range of 0 to 120,000 μmol · m-2 · day-1 was measured at site B. The mean and standard deviations associated with methane production at site A were 17 and 57 μmol · m-2 · day-1, respectively. The comparable summary statistics for site B were 2,000 and 9,900 μmol · m-2 · day-1. The coefficients of variation at sites A and B were 340 and 490%, respectively. Despite these differences, the two sites had similar seasonal trends, with the maximal rate of methane production occurring in summer. However, the relative variability associated with the seasonal rates changed very little. Our results suggest that (i) two spatially distinct sites exist in the aquifer, (ii) methanogenesis is a highly variable process, (iii) the coefficient of variation varied little with the rate of methane production, and (iv) in situ anaerobic biodegradation rates are lognormally distributed. PMID:16349410

Chronic inflammatory demyelinating polyneuropathy in children: a report of four patients with variable relapsing courses.

PubMed

Chang, Soo Jin; Lee, Ji Hyun; Kim, Shin Hye; Lee, Joon Soo; Kim, Heung Dong; Kang, Joon Won; Lee, Young Mock; Kang, Hoon-Chul

2015-05-01

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronically progressive or relapsing symmetric sensorimotor disorder presumed to occur because of immunologic antibody-mediated reactions. To understand the clinical courses of CIDP, we report variable CIDP courses in children with respect to initial presentation, responsiveness to medical treatment, and recurrence interval. Four patients who were diagnosed with acute-onset and relapsing CIDP courses at Severance Children's Hospital, Seoul, Korea, were enrolled in this retrospective study. We diagnosed each patient on the basis of the CIDP diagnostic criteria developed in 2010 by the European Federation of Neurological Societies/Peripheral Nerve Society Guidelines. We present the cases of four pediatric patients diagnosed with CIDP to understand the variable clinical course of the disease in children. Our four patients were all between 8 and 12 years of age. Patients 1 and 2 were diagnosed with acute cerebellar ataxia or Guillain-Barré syndrome as initial symptoms. While patients 1 and 4 were given only intravenous dexamethasone (0.3 mg/kg/day) for 5 days at the first episode, Patients 2 and 3 were given a combination of intravenous immunoglobulin (2 g/kg) and dexamethasone (0.3 mg/kg/day). All patients were maintained with oral prednisolone at 30 mg/day, but their clinical courses were variable in both relapse intervals and severity. We experienced variable clinical courses of CIDP in children with respect to initial presentation, responsiveness to medical treatment, and recurrence interval.

Effect of Escitalopram on Hot Flash Interference: A Randomized, Controlled Trial

PubMed Central

Carpenter, Janet S.; Guthrie, Katherine A.; Larson, Joseph C.; Freeman, Ellen W.; Joffe, Hadine; Reed, Susan D.; Ensrud, Kristine E.; LaCroix, Andrea Z.

2012-01-01

Objectives To estimate the effect of escitalopram 10–20 mg/day versus placebo for reducing hot flash interference in daily life and understand correlates and predictors of reductions in hot flash interference, a key measure of quality of life. Design Multi-site, randomized, double-blind, placebo-controlled clinical trial. Patients 205 midlife women (46% African-American) who met criteria participated. Setting MsFLASH clinical sites in Boston, Indianapolis, Oakland, and Philadelphia. Intervention After baseline, women were randomized to 1 pill of escitalopram 10 mg/day (n=104) or placebo (n=101) with follow-up at 4- and 8-weeks. At week 4, those not achieving 50% fewer hot flashes were increased to 2 pills daily (20 mg/day or 2 placebo pills). Main outcome measures The Hot Flash Related Daily Interference Scale; Correlates were variables from hot flash diaries; Predictors were baseline demographics, clinical variables, depression, anxiety, sleep quality, and hot flashes. Results Compared to placebo, escitalopram significantly reduced hot flash interference by 6.0 points at week 4 and 3.4 points at week 8 more than placebo (p=0.012). Reductions in hot flash interference correlated with changes in hot flash diary variables. However, baseline variables did not significantly predict reductions in hot flash interference. Conclusions Escitalopram 10–20mg/day for 8 weeks improves women’s quality of life and this benefit did not vary by demographic, clinical, mood, sleep, or hot flash variables. PMID:22480818

The impact of meteorology on the occurrence of waterborne outbreaks of vero cytotoxin-producing Escherichia coli (VTEC): a logistic regression approach.

PubMed

O'Dwyer, Jean; Morris Downes, Margaret; Adley, Catherine C

2016-02-01

This study analyses the relationship between meteorological phenomena and outbreaks of waterborne-transmitted vero cytotoxin-producing Escherichia coli (VTEC) in the Republic of Ireland over an 8-year period (2005-2012). Data pertaining to the notification of waterborne VTEC outbreaks were extracted from the Computerised Infectious Disease Reporting system, which is administered through the national Health Protection Surveillance Centre as part of the Health Service Executive. Rainfall and temperature data were obtained from the national meteorological office and categorised as cumulative rainfall, heavy rainfall events in the previous 7 days, and mean temperature. Regression analysis was performed using logistic regression (LR) analysis. The LR model was significant (p < 0.001), with all independent variables: cumulative rainfall, heavy rainfall and mean temperature making a statistically significant contribution to the model. The study has found that rainfall, particularly heavy rainfall in the preceding 7 days of an outbreak, is a strong statistical indicator of a waterborne outbreak and that temperature also impacts waterborne VTEC outbreak occurrence.

Agreement between auricular and rectal measurements of body temperature in healthy cats.

PubMed

Sousa, Marlos G; Carareto, Roberta; Pereira-Junior, Valdo A; Aquino, Monally C C

2013-04-01

Measurement of body temperature is a routine part of the clinical assessment of a patient. However, this procedure may be time-consuming and stressful to most animals because the standard site of temperature acquisition remains the rectal mucosa. Although an increasing number of clinicians have been using auricular temperature to estimate core body temperature, evidence is still lacking regarding agreement between these two methods in cats. In this investigation, we evaluated the agreement between temperatures measured in the rectum and ear in 29 healthy cats over a 2-week period. Temperatures were measured in the rectum (using digital and mercury-in-glass thermometers) and ear once a day for 14 consecutive days, producing 406 temperature readings for each thermometer. Mean temperature and confidence intervals were similar between methods, and Bland-Altman plots showed small biases and narrow limits of agreement acceptable for clinical purposes. The interobserver variability was also checked, which indicated a strong correlation between two near-simultaneous temperature readings. Results are consistent with auricular thermometry being a reliable alternative to rectal thermometry for assessing core body temperature in healthy cats.

[Violence against the elderly in the home environment: prevalence and associated factors (Recife, State of Pernambuco)].

PubMed

Duque, Andrezza Marques; Leal, Márcia Carrera Campos; Marques, Ana Paula de Oliveira; Eskinazi, Fernanda Maria Vieira; Duque, Amanda Marques

2012-08-01

The scope of this paper was to determine the prevalence and factors associated with domestic violence against the elderly. It is a cross-sectional study with 274 subjects, aged 60 years or more, of both sexes. Data were collected through interviews at home or in the USF based on a script structured in three parts: questionnaire with socio-demographic and bio-demographic information, two rating scales and a tool for identifying abuse. Among the respondents, 20.8% reported having experienced at least one type of violence in their home environment. An association was revealed between those living with a greater number of individuals, among women and elderly people who are dependent for day-to-day activities. After applying the logistic regression model, only the variables of sex and family configuration were significantly associated, with evidence of greater frequency among those who lived with six or more residents and women. These findings highlight the magnitude and seriousness of the problem and point to the need for action to combat violence against the elderly.

Diagnostic Studies with GLA Fields

NASA Technical Reports Server (NTRS)

Salstein, David A.

1997-01-01

Assessments of the NASA Goddard Earth Observing System-1 Data Assimilation System(GEOS-1 DAS), regarding heating rates, energetics, and angular momentum quantities were made. These diagnostics can be viewed as measures of climate variability. Comparisons with the NOAA/NCEP reanalysis system of momentum and energetics diagnostics are included. Water vapor and angular momentum are diagnosed in many models, including those of NASA, as part of the Atmospheric Model Intercomparison Project. 'Me GEOS-I and NOAA/NCEP global atmospheric angular momentum values are coherent on time scales down to about three days. Furthermore, they agree with the series of Earth angular momentum, as measured by tiny fluctuations in the rotation rate of the Earth, as variations in the length of day. The torques that effect such changes in atmospheric and Earth momentum are dominated by the influence of particular mountain systems, including the Rockies, Himalayas, and Andes, upon mountain torques on time scales shorter than about two weeks. Other project areas included collaboration with Goddard Space Flight Center to examine the impact of mountainous areas and the treatments of parameterizations on diagnoses of the atmosphere. Relevant preprints are included herein.

The impact of high progesterone levels on the day of HCG administration in assisted human reproduction treatments.

PubMed

Tanada, Michelli S; Yoshida, Ivan H; Santos, Monise; Berton, Caroline Z; Souto, Elen; Carvalho, Waldemar P de; Cordts, Emerson B; Barbosa, Caio P

2018-06-01

Progesterone is a steroid hormone that acts on the endometrium. It is known for producing physical and mood-related side effects. Few studies have looked into how progesterone levels affect embryo development and quality. This study aimed to find a cutoff level for serum progesterone on the day of HCG administration from which embryo quality is impaired. The study included 145 cycles, from which 885 oocytes and 613 embryos were obtained. All patients had their serum progesterone levels measured on the day of HCG administration. Data sets were collected from patient medical records. The chi-square test was used to assess qualitative variables and the Mann-Whitney test to evaluate quantitative variables. Statistical analysis revealed that serum progesterone levels and reproductive variables were not significantly associated. In regards to oocyte maturity, however, when progesterone levels were greater than 1.3 ng/mL the probability of oocytes being immature increased by 12.7%. The fragmentation rate of embryos categorized as "top quality" in D3 increased proportionately to increases in progesterone levels (12.23%). High progesterone levels appeared to be correlated with increased embryo fragmentation rates, but high serum levels of the hormone on the day of HCG administration had no impact on reproductive variables and were not associated with impaired embryo development.

Better or Worse: a Study of Day-to-Day Changes over Five Months of Rosen Method Bodywork Treatment for Chronic Low Back Pain

PubMed Central

Fogel, Alan

2013-01-01

Background Fluctuations of good days and bad days—in physical symptoms and emotional states—are common for individuals with chronic illness. This pilot study examines these fluctuations during bodywork treatment. Purpose We analyzed changes in daily self-reports over a period of five months for five individuals who received weekly treatments of Rosen Method Bodywork (RMB), which uses touch and words to enhance body awareness of physical sensations and emotional states. Subjects and Design Five subjects (aged 31–56) who had chronic low back pain (CLBP) received 16 weekly treatments given by three experienced RMB practitioners. Measures Pre- and posttreatment assessments covered demographics, disability, and pain. Clients also completed daily bedtime assessments of pain, fatigue, emotional state, and sense of control during the entire treatment period. Results All clients reported reductions in pain and/or disability in post- compared to pretreatment. In spite of a high level of day-to-day variability in the daily assessments, there were significant reductions in pain and fatigue, and significant increases in positive emotional state and sense of control across the treatment period. In reaching this end, however, some clients had slow and steady improvements, some improved more rapidly, while others got worse before they got better. Conclusions The natural course of healing—with its inevitable fluctuations in symptoms—is part of a process leading to successful treatment outcomes. Rosen Method Bodywork may be especially helpful in developing and accepting both sensory and emotional body awareness changes that facilitate overall improvement. PMID:24000305

Changes of human serum proteome profile during 7-day “dry” immersion

NASA Astrophysics Data System (ADS)

Pakharukova, N. A.; Pastushkova, L. Kh.; Larina, I. M.; Grigoriev, A. I.

2011-05-01

The aim of this study was to characterize changes of serum proteome profile during 7-day "dry" immersion (DI). The experiment with DI consisted of three series: control group without countermeasures (10 men), with using mechanical stimulation (6 men) and low-frequency myostimulation (5 men) as preventive means. Serum samples were fractionated using ClinProt robot (Bruker Daltonics) on magnetic beads (weak cation exchange magnetic beads—MB WCX) prior to mass-spectral profiling. It was obtained 170 peaks after fractionation of serum samples in each group. On 7th immersion day peak areas of fibrinopeptide A ( m/ z=1206; 1464), angiotensin II ( m/ z=1051), high molecular mass kininogen fragment ( m/ z=2133 Da) and C3-fragment of the complement system ( m/ z=1350 Da) were significantly decreased comparing with pre-experimental values of all experimental series. Peak areas of apolipoprotein C III ( m/ z=9419) and C4a fragment of the complement system ( m/ z=3206 Da) were increased. On 7th day of the recovery peak areas of all changed peaks were not close to pre-experimental values. This fact provided evidence of incomplete recovery of an organism after DI. The depth of the alterations had considerable individual variability. Thereby the detected changes of serum proteome profile in the experiment. They indicated a reorganization of the hormonal, immune systems and lipid metabolism. The use of myostimulation and mechanical stimulation as countermeasures partly compensated adverse effects of 7-day dry immersion on the parameters of coagulation system (fibrinopeptide A) and lipid metabolism (apolipoprotein CIII).

Safety and efficacy of blood glucose management practices at a diabetes camp.

PubMed

Gunasekera, Hasantha; Ambler, Geoffrey

2006-10-01

Camps are an important part of diabetic management in children yet data on the safety and efficacy of camps are limited. We assessed the safety and efficacy of blood glucose management guidelines at summer camps for diabetic children. Consistent management guidelines were implemented during 10 consecutive diabetes camps held in the same facility between 1998 and 2002. Using the entire sample of campers aged 9-13 years, we analysed insulin dosage alterations, the frequency of hypoglycaemia (<4 mmol/L), hyperglycaemia (>15 mmol/L) and ketosis and evaluated our overnight management guidelines. The effects of sex, year, age, insulin regimen and duration of diagnosis on hypoglycaemia frequency were determined. Mean insulin doses decreased 19.2% (95% confidence interval 16.9-21.6%) by the last day of camp (day 6) relative to the day prior to camp. Mean blood glucose levels were 11.4 mmol/L before breakfast and the main evening meal, 11.3 mmol/L before bed, 10.8 mmol/L at midnight and 9.4 mmol/L at 3 am. Of the 10 839 readings analysed, 984 (9.1%) were below 4 mmol/L (0.5 per camper/day) with no clinical grade 3 (seizure or coma) hypoglycaemia. Hypoglycaemia frequency was independent of sex, year, age, insulin regimen and duration of diagnosis (all P > 0.05). There were 2570 (23.7%) readings above 15 mmol/L (1.4 per camper/day) but only 42 (0.4%) were associated with significant ketosis. Children at diabetes camps experience considerable blood glucose variability; however, the careful application of monitoring and management guidelines can avoid serious adverse events.

Implications of the Observed Mesoscale Variations of Clouds for Earth's Radiation Budget

NASA Technical Reports Server (NTRS)

Rossow, William B.; Delo, Carl; Cairns, Brian; Hansen, James E. (Technical Monitor)

2001-01-01

The effect of small-spatial-scale cloud variations on radiative transfer in cloudy atmospheres currently receives a lot of research attention, but the available studies are not very clear about which spatial scales are important and report a very large range of estimates of the magnitude of the effects. Also, there have been no systematic investigations of how to measure and represent these cloud variations. We exploit the cloud climatology produced by the International Satellite Cloud Climatology Project (ISCCP) to: (1) define and test different methods of representing cloud variation statistics, (2) investigate the range of spatial scales that should be included, (3) characterize cloud variations over a range of space and time scales covering mesoscale (30 - 300 km, 3-12 hr) into part of the lower part of the synoptic scale (300 - 3000 km, 1-30 days), (4) obtain a climatology of the optical thickness, emissivity and cloud top temperature variability of clouds that can be used in weather and climate GCMS, together with the parameterization proposed by Cairns et al. (1999), to account for the effects of small-scale cloud variations on radiative fluxes, and (5) evaluate the effect of observed cloud variations on Earth's radiation budget. These results lead to the formulation of a revised conceptual model of clouds for use in radiative transfer calculations in GCMS. The complete variability climatology can be obtained from the ISCCP Web site at http://isccp.giss.nasa.gov.

Spatiotemporal patterns of precipitation extremes in the Poyang Lake basin, China: Changing properties and causes

NASA Astrophysics Data System (ADS)

Xiao, M.

2016-12-01

Under the background of climate change, extensive attentions have been paid on the increased extreme precipitation from the public and government. To analyze the influences of large-scale climate indices on the precipitation extremes, the spatiotemporal patterns of precipitation extremes in the Poyang Lake basin have been investigated using the Bayesian hierarchical method. The seasonal maximum one-day precipitation amount (Rx1day) was used to represent the seasonal precipitation extremes. Results indicated that spring Rx1day was affected by El Niño/Southern Oscillation (ENSO) and North Atlantic Oscillation (NAO), a positive ENSO event in the same year tends to decrease the spring Rx1day in the northern part of Poyang Lake Basin while increase the spring Rx1day in southeastern Poyang Lake Basin, a positive NAO events in the same year tends to increase the spring Rx1day in the southwest and northwest part of Poyang Lake basin while decrease the spring Rx1day in the eastern part of Poyang Lake basin; summer Rx1day was affected by Indian Ocean Dipole (IOD), positive IOD events in the same year tend to increase the summer Rx1day of northern Poyang Lake basin while decrease summer Rx1day of southern Poyang Lake basin; autumn Rx1day was affected by ENSO, positive ENSO events in the same year tend to mainly increase the autumn Rx1day in the west part of Poyang Lake basin; winter Rx1day was mainly affected by the NAO, positive NAO events in the same year tend to mainly increase the winter Rx1day of southern Poyang Lake basin, while positive NAO events in the previous year tend to mainly increase the winter Rx1day in the central and northeast part of Poyang Lake basin. It is considered that the region with the negative vertical velocity is dominated by more precipitation and vice versa. Furthermore, field patterns of 500 hPa vertical velocity anomalies related to each climate index have further corroborated the influences of climate indices on the seasonal Rx1day, and these will be important to further understand the possible geophysical processes linking the teleconnections of each climate index on the seasonal extreme precipitation in the Poyang Lake basin.

Final Report for Dynamic Models for Causal Analysis of Panel Data. Models for Change in Quantitative Variables, Part II Scholastic Models. Part II, Chapter 4.

ERIC Educational Resources Information Center

Hannan, Michael T.

This document is part of a series of chapters described in SO 011 759. Stochastic models for the sociological analysis of change and the change process in quantitative variables are presented. The author lays groundwork for the statistical treatment of simple stochastic differential equations (SDEs) and discusses some of the continuities of…

Selfies and the (Creative) Self: A Diary Study

PubMed Central

Karwowski, Maciej; Brzeski, Arkadiusz

2017-01-01

In this diary investigation, over 2 weeks we monitored the intensity of selfie posting among 292 Facebook users (60% females), aged between 18 and 50, to estimate the extent of selfying’s day-to-day variability and its predictors. The obtained effect was large; 64% of the variability in selfying was located within rather than between individuals. Day-to-day changes in creative activity explained a significant proportion of selfying, similarly as previous creative achievement did. At the same time, intelligence was negatively linked to the intensity of selfie posting and moderated the relationship between creative achievements and selfying. We discuss hypothetical links between selfie posting and the situational and individual differences characteristics related to creativity and cognitive abilities. PMID:28228743

49 CFR 214.533 - Schedule of repairs subject to availability of parts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Maintenance Machines and Hi-Rail Vehicles § 214.533 Schedule of repairs subject to availability of parts. (a... maintenance machine or a hi-rail vehicle by the end of the next business day following the report of the... maintenance machine or hi-rail vehicle within seven calendar days after receiving the necessary part. The...

Simulation of daily pesticide concentrations from watershed characteristics and monthly climatic data

USGS Publications Warehouse

Vecchia, Aldo V.; Crawford, Charles G.

2006-01-01

A time-series model was developed to simulate daily pesticide concentrations for streams in the coterminous United States. The model was based on readily available information on pesticide use, climatic variability, and watershed charac-teristics and was used to simulate concentrations for four herbicides [atrazine, ethyldipropylthiocarbamate (EPTC), metolachlor, and trifluralin] and three insecticides (carbofuran, ethoprop, and fonofos) that represent a range of physical and chemical properties, application methods, national application amounts, and areas of use in the United States. The time-series model approximates the probability distributions, seasonal variability, and serial correlation characteristics in daily pesticide concentration data from a national network of monitoring stations. The probability distribution of concentrations for a particular pesticide and station was estimated using the Watershed Regressions for Pesticides (WARP) model. The WARP model, which was developed in previous studies to estimate the probability distribution, was based on selected nationally available watershed-characteristics data, such as pesticide use and soil characteristics. Normality transformations were used to ensure that the annual percentiles for the simulated concentrations agree closely with the percentiles estimated from the WARP model. Seasonal variability in the transformed concentrations was maintained by relating the transformed concentration to precipitation and temperature data from the United States Historical Climatology Network. The monthly precipitation and temperature values were estimated for the centroids of each watershed. Highly significant relations existed between the transformed concentrations, concurrent monthly precipitation, and concurrent and lagged monthly temperature. The relations were consistent among the different pesticides and indicated the transformed concentrations generally increased as precipitation increased but the rate of increase depended on a temperature-dependent growing-season effect. Residual variability of the transformed concentrations, after removal of the effects of precipitation and temperature, was partitioned into a signal (systematic variability that is related from one day to the next) and noise (random variability that is not related from one day to the next). Variograms were used to evaluate measurement error, seasonal variability, and serial correlation of the historical data. The variogram analysis indicated substantial noise resulted, at least in part, from measurement errors (the differences between the actual concen-trations and the laboratory concentrations). The variogram analysis also indicated the presence of a strongly correlated signal, with an exponentially decaying serial correlation function and a correlation time scale (the time required for the correlation to decay to e-1 equals 0.37) that ranged from about 18 to 66 days, depending on the pesticide type. Simulated daily pesticide concentrations from the time-series model indicated the simulated concentrations for the stations located in the northeastern quadrant of the United States where most of the monitoring stations are located generally were in good agreement with the data. The model neither consistently overestimated or underestimated concentrations for streams that are located in this quadrant and the magnitude and timing of high or low concentrations generally coincided reasonably well with the data. However, further data collection and model development may be necessary to determine whether the model should be used for areas for which few historical data are available.

Reliability study of tibialis posterior and selected leg muscle EMG and multi-segment foot kinematics in rheumatoid arthritis associated pes planovalgus

PubMed Central

Barn, Ruth; Rafferty, Daniel; Turner, Deborah E.; Woodburn, James

2012-01-01

Objective To determine within- and between-day reliability characteristics of electromyographic (EMG) activity patterns of selected lower leg muscles and kinematic variables in patients with rheumatoid arthritis (RA) and pes planovalgus. Methods Five patients with RA underwent gait analysis barefoot and shod on two occasions 1 week apart. Fine-wire (tibialis posterior [TP]) and surface EMG for selected muscles and 3D kinematics using a multi-segmented foot model was undertaken barefoot and shod. Reliability of pre-determined variables including EMG activity patterns and inter-segment kinematics were analysed using coefficients of multiple correlation, intraclass correlation coefficients (ICC) and the standard error of the measurement (SEM). Results Muscle activation patterns within- and between-day ranged from fair-to-good to excellent in both conditions. Discrete temporal and amplitude variables were highly variable across all muscle groups in both conditions but particularly poor for TP and peroneus longus. SEMs ranged from 1% to 9% of stance and 4% to 27% of maximum voluntary contraction; in most cases the 95% confidence interval crossed zero. Excellent within-day reliability was found for the inter-segment kinematics in both conditions. Between-day reliability ranged from fair-to-good to excellent for kinematic variables and all ICCs were excellent; the SEM ranged from 0.60° to 1.99°. Conclusion Multi-segmented foot kinematics can be reliably measured in RA patients with pes planovalgus. Serial measurement of discrete variables for TP and other selected leg muscles via EMG is not supported from the findings in this cohort of RA patients. Caution should be exercised when EMG measurements are considered to study disease progression or intervention effects. PMID:22721819

Using present-day observations to detect when anthropogenic change forces surface ocean carbonate chemistry outside preindustrial bounds

NASA Astrophysics Data System (ADS)

Sutton, Adrienne J.; Sabine, Christopher L.; Feely, Richard A.; Cai, Wei-Jun; Cronin, Meghan F.; McPhaden, Michael J.; Morell, Julio M.; Newton, Jan A.; Noh, Jae-Hoon; Ólafsdóttir, Sólveig R.; Salisbury, Joseph E.; Send, Uwe; Vandemark, Douglas C.; Weller, Robert A.

2016-09-01

One of the major challenges to assessing the impact of ocean acidification on marine life is detecting and interpreting long-term change in the context of natural variability. This study addresses this need through a global synthesis of monthly pH and aragonite saturation state (Ωarag) climatologies for 12 open ocean, coastal, and coral reef locations using 3-hourly moored observations of surface seawater partial pressure of CO2 and pH collected together since as early as 2010. Mooring observations suggest open ocean subtropical and subarctic sites experience present-day surface pH and Ωarag conditions outside the bounds of preindustrial variability throughout most, if not all, of the year. In general, coastal mooring sites experience more natural variability and thus, more overlap with preindustrial conditions; however, present-day Ωarag conditions surpass biologically relevant thresholds associated with ocean acidification impacts on Mytilus californianus (Ωarag < 1.8) and Crassostrea gigas (Ωarag < 2.0) larvae in the California Current Ecosystem (CCE) and Mya arenaria larvae in the Gulf of Maine (Ωarag < 1.6). At the most variable mooring locations in coastal systems of the CCE, subseasonal conditions approached Ωarag = 1. Global and regional models and data syntheses of ship-based observations tended to underestimate seasonal variability compared to mooring observations. Efforts such as this to characterize all patterns of pH and Ωarag variability and change at key locations are fundamental to assessing present-day biological impacts of ocean acidification, further improving experimental design to interrogate organism response under real-world conditions, and improving predictive models and vulnerability assessments seeking to quantify the broader impacts of ocean acidification.

The origin of Total Solar Irradiance variability on timescales less than a day

NASA Astrophysics Data System (ADS)

Shapiro, Alexander; Krivova, Natalie; Schmutz, Werner; Solanki, Sami K.; Leng Yeo, Kok; Cameron, Robert; Beeck, Benjamin

2016-07-01

Total Solar Irradiance (TSI) varies on timescales from minutes to decades. It is generally accepted that variability on timescales of a day and longer is dominated by solar surface magnetic fields. For shorter time scales, several additional sources of variability have been proposed, including convection and oscillation. However, available simplified and highly parameterised models could not accurately explain the observed variability in high-cadence TSI records. We employed the high-cadence solar imagery from the Helioseismic and Magnetic Imager onboard the Solar Dynamics Observatory and the SATIRE (Spectral And Total Irradiance Reconstruction) model of solar irradiance variability to recreate the magnetic component of TSI variability. The recent 3D simulations of solar near-surface convection with MURAM code have been used to calculate the TSI variability caused by convection. This allowed us to determine the threshold timescale between TSI variability caused by the magnetic field and convection. Our model successfully replicates the TSI measurements by the PICARD/PREMOS radiometer which span the period of July 2010 to February 2014 at 2-minute cadence. Hence, we demonstrate that solar magnetism and convection can account for TSI variability at all timescale it has ever been measured (sans the 5-minute component from p-modes).

Droughts in the US: Modeling and Forecasting for Agriculture-Water Management and Adaptation

NASA Astrophysics Data System (ADS)

Perveen, S.; Devineni, N.; Lall, U.

2012-12-01

More than half of all US counties are currently mired in a drought that is considered the worst in decades. A persistent drought can not only lead to widespread impacts on water access with interstate implications (as has been shown in the Southeast US and Texas), chronic scarcity can emerge as a risk in regions where fossil aquifers have become the primary source of supply and are being depleted at rates much faster than recharge (e.g., Midwestern US). The standardized drought indices on which the drought declarations are made in the US so far consider only the static decision frameworks—where only the supply is the control variable and not the water consumption. If a location has low demands, drought as manifest in the usual indices does not really have "proportionate" social impact. Conversely, a modest drought as indicated by the traditional measures may have significant impacts where demand is close to the climatological mean value of precipitation. This may also lead to drought being declared too late or too soon. Against this fact, the importance of improved drought forecasting and preparedness for different sectors of the economy becomes increasingly important. The central issue we propose to address through this paper is the construction and testing of a drought index that considers regional water demands for specific purposes (e.g., crops, municipal use) and their temporal distribution over the year for continental US. Here, we have highlighted the use of the proposed index for three main sectors: (i) water management organizations, (ii) optimizing agricultural water use, and (iii) supply chain water risk. The drought index will consider day-to-day climate variability and sectoral demands to develop aggregate regional conditions or disaggregated indices for water users. For the daily temperature and precipitation data, we are using NLDAS dataset that is available from 1949 onwards. The national agricultural statistics services (NASS) online database has been accessed for the agricultural data at the county level. Preliminary analyses show that large parts of Midwest and Southern parts of Florida and California are prone to multiyear droughts. This can primarily be attributed to high agricultural and/or urban water demands coupled with high interannual variability in supply. We propose to develop season-ahead and monthly updated forecasts of the drought index for informing the drought management plans. Given the already customized (sector specific) nature of the proposed drought index and its ability to represent the variability in both supply and demand, the early warning or forecasting of the index would not only complement the drought early warning systems in place by the national integrated drought information system (NIDIS) but also help in prescribing the ameliorative measures for adaptation.

Four Day School Week for Small Rural Schools. Small Schools Fact Sheet.

ERIC Educational Resources Information Center

Culbertson, Jeanne

The four-day school week is a Monday-Thursday or Tuesday-Friday alternative to the traditional four-day week, which can be implemented with many variables and differing objectives. The four-day week saves heating, transportation, maintenance, electricity and some instructional costs, while providing better educational opportunities and use of…

Interactions Between Family and Day Care Systems. Final Technical Report.

ERIC Educational Resources Information Center

Romero, Det; And Others

This research report studied the relationship between families and day care centers as systems. Three levels of subjects were investigated: 23 day care centers in Lansing, Michigan, day care staffs and families of children enrolled. Three questionnaires were developed to obtain data on demographic and attitudinal variables. A director's…

Variability of Respiration and Metabolism: Responses to Submaximal Cycling and Running.

ERIC Educational Resources Information Center

Armstrong, Lawrence E.; Costill, David L.

1985-01-01

This investigation examined day-to-day variations in metabolic measurements during submaximal running and cycling. Significant differences were found in the oxygen uptake (VO2) of runners and cyclists and the minute ventilation (VE) of cyclists while running, but blood lactic acid (HLA) did not differ day to day. (Author/MT)

Inter-day Reliability of the IDEEA Activity Monitor for Measuring Movement and Non-Movement Behaviors in Older Adults.

PubMed

de la Cámara, Miguel Ángel; Higueras-Fresnillo, Sara; Martinez-Gomez, David; Veiga, Oscar L

2018-05-29

The inter-day reliability of the Intelligent Device for Energy Expenditure and Activity (IDEEA) has not been studied to date. The study purpose was to examine the inter-day variability and reliability on two consecutive days collected with the IDEEA, as well as to predict the number of days needed to provide a reliable estimate of several movement (walking and climbing stairs) and non-movement behaviors (lying, reclining, sitting) and standing in older adults. The sample included 126 older adults (74 women) who wore the IDEEA for 48-h. Results showed low variability between the two days and its reliability was from moderate (ICC=0.34) to high (ICC=0.80) in most of movement and non-movement behaviors analyzed. The Bland-Altman plots showed a high-moderate agreement between days and the Spearman-Brown formula estimated ranged from 1.2 and 9.1 days of monitoring with the IDEEA are needed to achieve ICCs≥0.70 in older adults for sitting and climbing stairs, respectively.

On climate prediction: how much can we expect from climate memory?

NASA Astrophysics Data System (ADS)

Yuan, Naiming; Huang, Yan; Duan, Jianping; Zhu, Congwen; Xoplaki, Elena; Luterbacher, Jürg

2018-03-01

Slowing variability in climate system is an important source of climate predictability. However, it is still challenging for current dynamical models to fully capture the variability as well as its impacts on future climate. In this study, instead of simulating the internal multi-scale oscillations in dynamical models, we discussed the effects of internal variability in terms of climate memory. By decomposing climate state x(t) at a certain time point t into memory part M(t) and non-memory part ɛ (t) , climate memory effects from the past 30 years on climate prediction are quantified. For variables with strong climate memory, high variance (over 20% ) in x(t) is explained by the memory part M(t), and the effects of climate memory are non-negligible for most climate variables, but the precipitation. Regarding of multi-steps climate prediction, a power law decay of the explained variance was found, indicating long-lasting climate memory effects. The explained variances by climate memory can remain to be higher than 10% for more than 10 time steps. Accordingly, past climate conditions can affect both short (monthly) and long-term (interannual, decadal, or even multidecadal) climate predictions. With the memory part M(t) precisely calculated from Fractional Integral Statistical Model, one only needs to focus on the non-memory part ɛ (t) , which is an important quantity that determines climate predictive skills.

Meteorological variables affect fertility rate after intrauterine artificial insemination in sheep in a seasonal-dependent manner: a 7-year study.

PubMed

Palacios, C; Abecia, J A

2015-05-01

A total number of 48,088 artificial inseminations (AIs) have been controlled during seven consecutive years in 79 dairy sheep Spanish farms (41° N). Mean, maximum and minimum ambient temperatures (Ts), temperature amplitude (TA), mean relative humidity (RH), mean solar radiation (SR) and total rainfall of each insemination day and 15 days later were recorded. Temperature-humidity index (THI) and effective temperature (ET) have been calculated. A binary logistic regression model to estimate the risk of not getting pregnant compared to getting pregnant, through the odds ratio (OR), was performed. Successful winter inseminations were carried out under higher SR (P < 0.01) and summer inseminations under lower SR values (P < 0.05). Successful inseminations during the summer were performed under significantly lower maximum T (P < 0.01), while winter inseminations resulted in pregnancy when they were carried out under higher maximum (P < 0.05) and minimum Ts (P < 0.01). Up to five meteorological variables presented OR >1 (maximum T, ET and rainfall on AI day, and ET and rainfall on day 15), and two variables presented OR <1 (SR on AI day and maximum T on day 15). However, the effect of meteorological factors affected fertility in opposite ways, so T becomes a protective or risk factor on fertility depending on season. In conclusion, the percentage of pregnancy after AI in sheep is significantly affected by meteorological variables in a seasonal-dependent manner, so the parameters such as temperature reverse their effects in the hot or cold seasons. A forecast of the meteorological conditions could be a useful tool when AI dates are being scheduled.

The periodontal abscess (II). Short-term clinical and microbiological efficacy of 2 systemic antibiotic regimes.

PubMed

Herrera, D; Roldán, S; O'Connor, A; Sanz, M

2000-06-01

The aim of this short-term open parallel longitudinal clinical study was to compare the clinical and microbiological efficacy of 2 different antibiotic regimes in the treatment of acute periodontal abscesses. After patient selection, a clinical examination was carried out recording the following variables: pain, edema, redness, swelling, bleeding on probing, suppuration, tooth mobility, lymphadenopathy, and probing pocket depth. Microbiological samples were taken from the lesion and the patient was randomly assigned to one of two antibiotic regimes: azithromycin or amoxicillin/clavulanate. Clinical variables were recorded, and microbiological samples were taken, at 3-5 days, 10-12 days and 30 days. Additional mechanical treatment (debridement and scaling) was performed in the third visit (10-12 days). Blood and urine samples were collected at baseline and after 10-12 days. Microbiological samples were processed by anaerobic culturing, and isolated periodontal pathogens were tested for antibiotic susceptibility by means of the spiral gradient endpoint methodology. 15 patients took azithromycin, and 14 amoxicillin/clavulanate. Subjective clinical variables demonstrated statistically significant improvements with both antibiotic regimes, which lasted for at least 1 month (p<0.01). Objective clinical variables also showed clear improvements, being statistically significant after 30 days with probing pocket depth in the azithromycin group (p<0.01). Microbiologically, short-term reductions were detected with both antibiotics, however fast recolonization occurred after the third visit. No significant differences were found between both treatment regimes. Antibiotic susceptibilities demonstrated no resistances for amoxicillin/clavulanate, while 2-3 strains of each studied pathogen were resistant to azithromycin. However, both antibiotic regimes were effective in the short-term treatment of periodontal abscesses in periodontitis patients.

Low within- and between-day variability in exposure to new insulin glargine 300 U/ml.

PubMed

Becker, R H A; Nowotny, I; Teichert, L; Bergmann, K; Kapitza, C

2015-03-01

To characterize the variability in exposure and metabolic effect of insulin glargine 300 U/ml (Gla-300) at steady state in people with type 1 diabetes (T1DM). A total of 50 participants with T1DM underwent two 24-h euglycaemic clamps in steady-state conditions after six once-daily administrations of 0.4 U/kg Gla-300 in a double-blind, randomized, two-treatment, two-period, crossover clamp study. Participants were randomized to receive Gla-300 as a standard cartridge formulation in the first treatment period, and as a formulation with enhanced stability through polysorbate-20 addition in the second treatment period, or vice versa. This design allowed the assessment of bioequivalence between formulations and, subsequently, within- and between-day variability. The cumulative exposure and effect of Gla-300 developed linearly over 24 h, and were evenly distributed across 6- and 12-h intervals. Diurnal fluctuation in exposure (within-day variability) was low; the peak-to-trough ratio of insulin concentration profiles was <2, and both the swing and peak-to-trough fluctuation were <1. Day-to-day reproducibility of exposure was high: the between-day within-subject coefficients of variation for total systemic exposure (area under the serum insulin glargine concentration time curve from time 0 to 24 h after dosing) and maximum insulin concentration were 17.4% [95% confidence interval (CI) 15-21] and 33.4% (95% CI 28-41), respectively. Reproducibility of the metabolic effect was lower than that of exposure. Gla-300 provides predictable, evenly distributed 24-h coverage as a result of low fluctuation and high reproducibility in insulin exposure, and appears suitable for effective basal insulin use. © 2014 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.

Meteorological variables affect fertility rate after intrauterine artificial insemination in sheep in a seasonal-dependent manner: a 7-year study

NASA Astrophysics Data System (ADS)

Palacios, C.; Abecia, J. A.

2015-05-01

A total number of 48,088 artificial inseminations (AIs) have been controlled during seven consecutive years in 79 dairy sheep Spanish farms (41° N). Mean, maximum and minimum ambient temperatures ( Ts), temperature amplitude (TA), mean relative humidity (RH), mean solar radiation (SR) and total rainfall of each insemination day and 15 days later were recorded. Temperature-humidity index (THI) and effective temperature (ET) have been calculated. A binary logistic regression model to estimate the risk of not getting pregnant compared to getting pregnant, through the odds ratio (OR), was performed. Successful winter inseminations were carried out under higher SR ( P < 0.01) and summer inseminations under lower SR values ( P < 0.05). Successful inseminations during the summer were performed under significantly lower maximum T ( P < 0.01), while winter inseminations resulted in pregnancy when they were carried out under higher maximum ( P < 0.05) and minimum Ts ( P < 0.01). Up to five meteorological variables presented OR >1 (maximum T, ET and rainfall on AI day, and ET and rainfall on day 15), and two variables presented OR <1 (SR on AI day and maximum T on day 15). However, the effect of meteorological factors affected fertility in opposite ways, so T becomes a protective or risk factor on fertility depending on season. In conclusion, the percentage of pregnancy after AI in sheep is significantly affected by meteorological variables in a seasonal-dependent manner, so the parameters such as temperature reverse their effects in the hot or cold seasons. A forecast of the meteorological conditions could be a useful tool when AI dates are being scheduled.

Association between ozone and asthma emergency department visits in Saint John, New Brunswick, Canada.

PubMed Central

Stieb, D M; Burnett, R T; Beveridge, R C; Brook, J R

1996-01-01

This study examines the relationship of asthma emergency department (ED) visits to daily concentrations of ozone and other air pollutants in Saint John, New Brunswick, Canada. Data on ED visits with a presenting complaint of asthma (n = 1987) were abstracted for the period 1984-1992 (May-September). Air pollution variables included ozone, sulfur dioxide, nitrogen dioxide, sulfate, and total suspended particulate (TSP); weather variables included temperature, humidex, dewpoint, and relative humidity. Daily ED visit frequencies were filtered to remove day of the week and long wave trends, and filtered values were regressed on air pollution and weather variables for the same day and the 3 previous days. The mean daily 1-hr maximum ozone concentration during the study period was 41.6 ppb. A positive, statistically significant (p < 0.05) association was observed between ozone and asthma ED visits 2 days later, and the strength of the association was greater in nonlinear models. The frequency of asthma ED visits was 33% higher (95% CI, 10-56%) when the daily 1-hr maximum ozone concentration exceeded 75 ppb (the 95th percentile). The ozone effect was not significantly influenced by the addition of weather or other pollutant variables into the model or by the exclusion of repeat ED visits. However, given the limited number of sampling days for sulfate and TSP, a particulate effect could not be ruled out. We detected a significant association between ozone and asthma ED visits, despite the vast majority of sampling days being below current U.S. and Canadian standards. Images Figure 1. A Figure 1. B Figure 2. Figure 3. PMID:9118879

Prognostic model for psychological outcomes in ambulatory surgery patients: A prospective study using a structural equation modeling framework.

PubMed

Mijderwijk, Hendrik-Jan; Stolker, Robert Jan; Duivenvoorden, Hugo J; Klimek, Markus; Steyerberg, Ewout W

2018-01-01

Surgical procedures are increasingly carried out in a day-case setting. Along with this increase, psychological outcomes have become prominent. The objective was to evaluate prospectively the prognostic effects of sociodemographic, medical, and psychological variables assessed before day-case surgery on psychological outcomes after surgery. The study was carried out between October 2010 and September 2011. We analyzed 398 mixed patients, from a randomized controlled trial, undergoing day-case surgery at a university medical center. Structural equation modeling was used to jointly study presurgical prognostic variables relating to sociodemographics (age, sex, nationality, marital status, having children, religion, educational level, employment), medical status (BMI, heart rate), and psychological status associated with anxiety (State-Trait Anxiety Inventory (STAI), Hospital Anxiety and Depression Scale (HADS-A)), fatigue (Multidimensional Fatigue Inventory (MFI)), aggression (State-Trait Anger Scale (STAS)), depressive moods (HADS-D), self-esteem, and self-efficacy. We studied psychological outcomes on day 7 after surgery, including anxiety, fatigue, depressive moods, and aggression regulation. The final prognostic model comprised the following variables: anxiety (STAI, HADS-A), fatigue (MFI), depression (HADS-D), aggression (STAS), self-efficacy, sex, and having children. The corresponding psychological variables as assessed at baseline were prominent (i.e. standardized regression coefficients ≥ 0.20), with STAI-Trait score being the strongest predictor overall. STAI-State (adjusted R2 = 0.44), STAI-Trait (0.66), HADS-A (0.45) and STAS-Trait (0.54) were best predicted. We provide a prognostic model that adequately predicts multiple postoperative outcomes in day-case surgery. Consequently, this enables timely identification of vulnerable patients who may require additional medical or psychological preventive treatment or-in a worst-case scenario-could be unselected for day-case surgery.

5 CFR 610.406 - Holiday for employees on compressed work schedules.

Code of Federal Regulations, 2010 CFR

2010-01-01

... number of hours of the compressed work schedule on that day. (b) If a part-time employee is relieved or... of the compressed work schedule on that day. When a holiday falls on a nonworkday of a part-time... work schedules. (a) If a full-time employee is relieved or prevented from working on a day designated...

Variability of insulin degludec and glargine U300: A matter of methodology or just marketing?

PubMed

Heise, Tim; Heckermann, Sascha; DeVries, J Hans

2018-05-17

The variability in the time-action profiles of insulin preparations, in particular basal insulins, has been a matter of debate ever since the publication of a glucose clamp study comparing the day-to-day variability of three different basal insulins (glargine U100, detemir and NPH) in 2004 [1]. While critics did not contest the findings of a lower variability of some basal insulins in this and a later [2] glucose clamp study, they did question the relevance of a lower pharmacokinetic (PK) and pharmacodynamic (PD) variability for clinical endpoints [3, 4]. Nevertheless, this has not stopped marketeers to widely use the results of glucose clamp studies promoting insulins for higher predictability or a suggested flat PK/PD-profile fully covering 24 hours [5]. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Using present day observations to detect when ocean acidification exceeds natural variability of surface seawater Ωaragonite

NASA Astrophysics Data System (ADS)

Sutton, A.; Sabine, C. L.; Feely, R. A.

2016-02-01

One of the major challenges to assessing the impact of ocean acidification on marine life is the need to better understand the magnitude of long-term change in the context of natural variability. High-frequency moored observations can be highly effective in defining interannual, seasonal, and subseasonal variability at key locations. Here we present monthly aragonite saturation state (Ωaragonite) climatology for 15 open ocean, coastal, and coral reef locations using 3-hourly moored observations of surface seawater pCO2 and pH collected together since as early as 2009. We then use these present day surface mooring observations to estimate pre-industrial variability at each location and compare these results to previous modeling studies addressing global-scale variability and change. Our observations suggest that open oceans sites, especially in the subtropics, are experiencing Ωaragonite values throughout much of the year which are outside the range of pre-industrial values. In coastal and coral reef ecosystems, which have higher natural variability, seasonal patterns where present day Ωaragonite values exceeding pre-industrial bounds are emerging with some sites exhibiting subseasonal conditions approaching Ωaragonite = 1. Linking these seasonal patterns in carbonate chemistry to biological processes in these regions is critical to identify when and where marine life may encounter Ωaragonite values outside the conditions to which they have adapted.

Evaporation from a shallow, saline lake in the Nebraska Sandhills: Energy balance drivers of seasonal and interannual variability

NASA Astrophysics Data System (ADS)

Riveros-Iregui, Diego A.; Lenters, John D.; Peake, Colin S.; Ong, John B.; Healey, Nathan C.; Zlotnik, Vitaly A.

2017-10-01

Despite potential evaporation rates in excess of the local precipitation, dry climates often support saline lakes through groundwater inputs of water and associated solutes. These groundwater-fed lakes are important indicators of environmental change, in part because their shallow water levels and salinity are very sensitive to weather and climatic variability. Some of this sensitivity arises from high rates of open-water evaporation, which is a dominant but poorly quantified process for saline lakes. This study used the Bowen ratio energy budget method to calculate open-water evaporation rates for Alkali Lake, a saline lake in the Nebraska Sandhills region (central United States), where numerous groundwater-fed lakes occupy the landscape. Evaporation rates were measured during the warm season (May - October) over three consecutive years (2007-2009) to gain insights into the climatic and limnological factors driving evaporation, as well as the partitioning of energy balance components at seasonal and interannual time scales. Results show a seasonal peak in evaporation rate in late June of 7.0 mm day-1 (on average), with a maximum daily rate of 10.5 mm day-1 and a 3-year mean July-September (JAS) rate of 5.1 mm day-1, which greatly exceeds the long-term JAS precipitation rate of 1.3 mm day-1. Seasonal variability in lake evaporation closely follows that of net radiation and lake surface temperature, with sensible heat flux and heat storage variations being relatively small, except in response to short-term, synoptic events. Interannual changes in the surface energy balance were weak, by comparison, although a 6-fold increase in mean lake level over the three years (0.05-0.30 m) led to greater heat storage within the lake, an enhanced JAS lake-air temperature gradient, and greater sensible heat loss. These large variations in water level were also associated with large changes in absolute salinity (from 28 to 118 g kg-1), with periods of high salinity characterized by reductions in mass transfer estimates of evaporation rate by up to 20%, depending on atmospheric conditions and absolute salinity. Energy balance estimates of evaporation, on the other hand, were found to be less sensitive to variations in salinity. These results provide regional insights for lakes in the Nebraska Sandhills region and implications for estimation of the energy and water balance of saline lakes in similar arid and semi-arid landscapes.

[Consequences of short term fluctuations of the environmental temperatures in calves--Part 2: Effects on the health status of animals within three weeks after exposure].

PubMed

Reinhold, P; Elmer, S

2002-04-01

The aim of the present study was to examine consequences of sudden changes in ambient temperature over a 4-hour period (see part 1 [ELMER & REINHOLD, 2002]) on respiratory health in clinically healthy calves. Therefore, the relationship between short-term changes in ambient temperature and the occurrence of clinical respiratory disease was checked over a period of 3 weeks after exposure in 10 calves exposed to 5 degrees C, in 9 calves exposed to 35 degrees C and in 8 control calves (kept at 18-20 degrees C). Within the period beginning 3 days before exposure and lasting until up to 21 days after exposure, each calf was examined clinically. Rectal temperature and respiratory rate were measured daily. All calves were euthanised on day 21 after exposure. Macroscopically visible pneumonic lesions were evaluated using a semiquantitative system. Tissue samples from tonsils, bronchi, trachea, lung and mediastinal lymph nodes were examined bacteriologically. In contrast to non-exposed control calves, severe respiratory illness was observed in individual calves of both exposed groups (5 degrees C, 35 degrees C). Significant increases in body temperature, respiratory rate and animal losses (2 calves died in the group exposed to 5 degrees C, one calf died in the group exposed to 35 degrees C) were the main clinical findings. At necropsy (3 weeks after exposure), no pneumonic lesions were observed in control calves--despite the fact that this group had the highest microbiological colonisation rates in tonsils and in large airways, i.e. trachea and bronchi, within all groups. However, variable pneumonic lung lesions were seen in remaining calves exposed to cold or warm air (5 degrees C, 35 degrees C). The microbiological examination confirmed that mainly Mycoplasma spp. were identified in the lung tissue of calves exposed to 5 degrees C while Pasteurella multocida and/or Mannheimia haemolytica were the only germs found in the lung tissue of calves exposed to 35 degrees C. The results of parts 1 and 2 of the present study related to health issues of calves should be taken into account for future legislation on animal welfare.

17 CFR Appendix C to Part 30 - Foreign Petitioners Granted Relief From the Application of Certain of the Part 30 Rules Pursuant...

Code of Federal Regulations, 2013 CFR

2013-04-01

... Rectora de Productos Financieros Derivados de Renta Fija (“MEFF Renta Fija”). FR date and citation: June 9... Productos Financieros Derivados de Renta Variable (“MEFF Rental Variable.”) FR date and citation: April 8...

17 CFR Appendix C to Part 30 - Foreign Petitioners Granted Relief From the Application of Certain of the Part 30 Rules Pursuant...

Code of Federal Regulations, 2012 CFR

2012-04-01

... Rectora de Productos Financieros Derivados de Renta Fija (“MEFF Renta Fija”). FR date and citation: June 9... Productos Financieros Derivados de Renta Variable (“MEFF Rental Variable.”) FR date and citation: April 8...

Day-to-day variability of midlatitude ionospheric currents due to magnetospheric and lower atmospheric forcing

NASA Astrophysics Data System (ADS)

Yamazaki, Y.; Häusler, K.; Wild, J. A.

2016-07-01

As known from previous studies on the solar quiet (Sq) variation of the geomagnetic field, the strength and pattern of ionospheric dynamo currents change significantly from day to day. The present study investigates the relative importance of two sources that contribute to the day-to-day variability of the ionospheric currents at middle and low latitudes. One is high-latitude electric fields that are caused by magnetospheric convection, and the other is atmospheric waves from the lower atmosphere. Global ionospheric current systems, commonly known as Sq current systems, are simulated using the National Center for Atmospheric Research thermosphere-ionosphere-mesosphere-electrodynamics general circulation model. Simulations are run for 1-30 April 2010 with a constant solar energy input but with various combinations of high-latitude forcing and lower atmospheric forcing. The model well reproduces geomagnetic perturbations on the ground, when both forcings are taken into account. The contribution of high-latitude forcing to the total Sq current intensity (Jtotal) is generally smaller than the contribution of wave forcing from below 30 km, except during active periods (Kp≥4), when Jtotal is enhanced due to the leakage of high-latitude electric fields to lower latitudes. It is found that the penetration electric field drives ionospheric currents at middle and low latitudes not only on the dayside but also on the nightside, which has an appreciable effect on the Dst index. It is also found that quiet time day-to-day variability in Jtotal is dominated by symmetric-mode migrating diurnal and semidiurnal tidal winds at 45-60° latitude at ˜110 km.

The PCR-based detection of Trypanosoma cruzi in the faeces of Triatoma infestans fed on patients with chronic American trypanosomiasis gives higher sensitivity and a quicker result than routine xenodiagnosis.

PubMed

Zulantay, I; Apt, W; Gil, L C; Rocha, C; Mundaca, K; Solari, A; Sánchez, G; Rodriguez, C; Martínez, G; De Pablos, L M; Sandoval, L; Rodríguez, J; Vilchez, S; Osuna, A

2007-12-01

In the xenodiagnosis (XD) of American trypanosomiasis (Chagas disease), Trypanosoma cruzi in the triatomine bugs fed on the patient can now be detected using PCR (XD-PCR) as well as by microscopy (XD-M). In a study to compare XD-PCR with XD-M, triatomine bugs were fed on 50 cases of chronic American trypanosomiasis, of whom only 25 were ever found positive by XD-M. Overall, the bugs fed on 34 of the patients (all 25 cases found positive by XD-M and nine of the other patients) were found PCR-positive, giving a 330-bp fragment corresponding to part of the hyper variable region of the kinetoplast DNA of T. cruzi. Of the 25 patients who were ever found positive by XD-M, 20 gave bugs that were smear-positive on day 90 and a similar number (24; P=0.125) gave bugs that were PCR-positive at this time. On day 30, however, the bugs fed on only 11 of these 25 patients were found positive by microscopy, whereas 23 of these patients were found positive by XD-PCR (P=0.0016). Thus, not only was XD-PCR more sensitive than XD-M but it was also quicker, revealing more cases within 30 days than detected using XD-M over a period of 90 days.

Evaluation of a method of estimating low-flow frequencies from base-flow measurements at Indiana streams

USGS Publications Warehouse

Wilson, John Thomas

2000-01-01

A mathematical technique of estimating low-flow frequencies from base-flow measurements was evaluated by using data for streams in Indiana. Low-flow frequencies at low- flow partial-record stations were estimated by relating base-flow measurements to concurrent daily flows at nearby streamflow-gaging stations (index stations) for which low-flowfrequency curves had been developed. A network of long-term streamflow-gaging stations in Indiana provided a sample of sites with observed low-flow frequencies. Observed values of 7-day, 10-year low flow and 7-day, 2-year low flow were compared to predicted values to evaluate the accuracy of the method. Five test cases were used to evaluate the method under a variety of conditions in which the location of the index station and its drainage area varied relative to the partial-record station. A total of 141 pairs of streamflow-gaging stations were used in the five test cases. Four of the test cases used one index station, the fifth test case used two index stations. The number of base-flow measurements was varied for each test case to see if the accuracy of the method was affected by the number of measurements used. The most accurate and least variable results were produced when two index stations on the same stream or tributaries of the partial-record station were used. All but one value of the predicted 7-day, 10-year low flow were within 15 percent of the values observed for the long-term continuous record, and all of the predicted values of the 7-day, 2-year lowflow were within 15 percent of the observed values. This apparent accuracy, to some extent, may be a result of the small sample set of 15. Of the four test cases that used one index station, the most accurate and least variable results were produced in the test case where the index station and partial-record station were on the same stream or on streams tributary to each other and where the index station had a larger drainage area than the partial-record station. In that test case, the method tended to over predict, based on the median relative error. In 23 of 28 test pairs, the predicted 7-day, 10-year low flow was within 15 percent of the observed value; in 26 of 28 test pairs, the predicted 7-day, 2-year low flow was within 15 percent of the observed value. When the index station and partial-record station were on the same stream or streams tributary to each other and the index station had a smaller drainage area than the partial-record station, the method tended to under predict the low-flow frequencies. Nineteen of 28 predicted values of the 7-day, 10-year low flow were within 15 percent of the observed values. Twenty-five of 28 predicted values of the 7-day, 2-year low flow were within 15 percent of the observed values. When the index station and the partial-record station were on different streams, the method tended to under predict regardless of whether the index station had a larger or smaller drainage area than that of the partial-record station. Also, the variability of the relative error of estimate was greatest for the test cases that used index stations and partial-record stations from different streams. This variability, in part, may be caused by using more streamflow-gaging stations with small low-flow frequencies in these test cases. A small difference in the predicted and observed values can equate to a large relative error when dealing with stations that have small low-flow frequencies. In the test cases that used one index station, the method tended to predict smaller low-flow frequencies as the number of base-flow measurements was reduced from 20 to 5. Overall, the average relative error of estimate and the variability of the predicted values increased as the number of base-flow measurements was reduced.

Individuals with Type 1 and Type 2 Diabetes Mellitus Trade Increased Hyperglycemia for Decreased Hypoglycemia When Glycemic Variability is not Improved.

PubMed

Jangam, Sujit R; Hayter, Gary; Dunn, Timothy C

2018-02-01

Glycemic variability refers to oscillations in blood glucose within a day and differences in blood glucose at the same time on different days. Glycemic variability is linked to hypoglycemia and hyperglycemia. The relationship among these three important metrics is examined here, specifically to show how reduction in both hypo- and hyperglycemia risk is dependent on changes in variability. To understand the importance of glycemic variability in the simultaneous reduction of hypoglycemia and hyperglycemia risk, we introduce the glycemic risk plot-estimated HbA1c % (eA1c) vs. minutes below 70 mg/dl (MB70) with constant variability contours for predicting post-intervention risks in the absence of a change in glycemic variability. The glycemic risk plot illustrates that individuals who do not reduce glycemic variability improve one of the two metrics (hypoglycemia risk or hyperglycemia risk) at the cost of the other. It is important to reduce variability to improve both risks. These results were confirmed by data collected in a randomized controlled trial consisting of individuals with type 1 and type 2 diabetes on insulin therapy. For type 1, a total of 28 individuals out of 35 (80%) showed improvement in at least one of the risks (hypo and/or hyper) during the 100-day course of the study. Seven individuals (20%) showed improvement in both. Similar data were observed for type 2 where a total of 36 individuals out of 43 (84%) showed improvement in at least one risk and 8 individuals (19%) showed improvement in both. All individuals in the study who showed improvement in both hypoglycemia and hyperglycemia risk also showed a reduction in variability. Therapy changes intended to improve an individual's hypoglycemia or hyperglycemia risk often result in the reduction of one risk at the expense of another. It is important to improve glucose variability to reduce both risks or at least maintain one risk while reducing the other. Abbott Diabetes Care.

Variability in Deposition Rates and Mean Days of Hospitalization for the 100 Most Common Diagnostic Codes in U.S. Army Health Services Command Facilities.

DTIC Science & Technology

1992-06-02

artificially high degree of variability across regions. Mean bed days reflect provider behavior once the patient is hospitalized. However, variation in...0.12 3 4149 CHRONIC ISCHEMIC HEARR DISEASE :3.55 4.01 7.47 1.15 ’ 5243 ANOMALIES TOOTH POSITION 1.25 0.94 11.69 0.46 9 6565 POOR FETAL GROWTH 9.26

Econotherapeutics.

PubMed

Roark, M K; Reed, W E

1995-01-01

A program that represents the efforts of a hospital pharmacy management company to control drug costs is described. The program, Econotherapeutics, was developed in response to a changed health care reimbursement system that focused on the costs of products rather than the revenue generated by these products. For antimicrobial agents, a hospital-specific antibiogram is used to encourage cost-effective prescribing. A pharmacist intervention program, medical staff presentations, drug usage evaluation, management systems, and educational programs for pharmacists are all essential parts of the program. Centralized data gathering has allowed cost comparison of specific antimicrobial agents so that differences between variable cost estimates and costs based on actual use can be evaluated. Actual dose and dosage interval were used to calculate average cost per treatment day in a 121-hospital sample. Our cost data support the choice of cefotaxime over ceftriaxone.

Improvement of Forest Fire Detection Algorithm Using Brightness Temperature Lapse Rate Correction in HIMAWARI-8 IR Channels: Application to the 6 may 2017 Samcheok City, Korea

NASA Astrophysics Data System (ADS)

Park, S. H.; Park, W.; Jung, H. S.

2018-04-01

Forest fires are a major natural disaster that destroys a forest area and a natural environment. In order to minimize the damage caused by the forest fire, it is necessary to know the location and the time of day and continuous monitoring is required until fire is fully put out. We have tried to improve the forest fire detection algorithm by using a method to reduce the variability of surrounding pixels. We focused that forest areas of East Asia, part of the Himawari-8 AHI coverage, are mostly located in mountainous areas. The proposed method was applied to the forest fire detection in Samcheok city, Korea on May 6 to 10, 2017.

Intraseasonal variability in atmospheric surface pressure and relationship to polar motion

NASA Technical Reports Server (NTRS)

Salstein, David A.; Rosen, Richard D.

1988-01-01

Two techniques were used to validate the theoretical relationship between polar motion and P sub s variations. The first method, reproduced from Hide et al. (1984), compares the fluctuations in physical space of the polar spirals and the high frequencies about them. Although the agreement appears reasonable, the lack of a clear measure of closeness and the presence of the large Chandler signal itself makes a comparison at higher frequencies difficult. To overcome this difficulty, the authors present the X functions required to maintain the observed fluctuations at roughly 20 to 70 days and those calculated from the National Meteorological Center (NMC) P sub s data. These curves are in relatively good agreement, indicating that polar motions are indeed driven, at least in large part, by fluctuations in P sub s.

Antiviral Activity, Safety, and Exposure-Response Relationships of GSK3532795, a Second-Generation Human Immunodeficiency Virus Type 1 Maturation Inhibitor, Administered as Monotherapy or in Combination With Atazanavir With or Without Ritonavir in a Phase 2a Randomized, Dose-Ranging, Controlled Trial (AI468002).

PubMed

Hwang, Carey; Schürmann, Dirk; Sobotha, Christian; Boffito, Marta; Sevinsky, Heather; Ray, Neelanjana; Ravindran, Palanikumar; Xiao, Hong; Keicher, Christian; Hüser, Andreas; Krystal, Mark; Dicker, Ira B; Grasela, Dennis; Lataillade, Max

2017-08-01

GSK3532795 is a second-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor that targets HIV-1 Gag, inhibiting the final protease cleavage between capsid protein p24 and spacer protein-1, producing immature, noninfectious virions. This was a phase 2a, randomized, dose-ranging multipart trial. In part A, subtype B-infected subjects received 5-120 mg GSK3532795 (or placebo) once daily for 10 days. In part B, subtype B-infected subjects received 40 mg or 80 mg GSK3532795 once daily with atazanavir (ATV) with or without (±) ritonavir (RTV) or standard of care (SOC) (tenofovir disoproxil fumarate 300 mg, emtricitabine 200 mg, and ATV/RTV 300 mg/100 mg) for 28 days. In part C, subtype C-infected subjects received 40 mg or 120 mg GSK3532795 once daily (or placebo) for 10 days. Endpoints included change in HIV-1 RNA from baseline on day 11 (parts A/C) or day 29 (part B). A >1 log10 median decline in HIV-1 RNA was achieved by day 11 in parts A and C and day 29 in part B at GSK3532795 doses ≥40 mg; part B subjects receiving GSK3532795 and ATV ± RTV achieved similar declines to those receiving SOC. Median of the maximum declines in HIV-1 RNA were similar for the 40-120 mg once-daily dose groups regardless of baseline Gag polymorphisms. There were no deaths, adverse events leading to discontinuation, or serious adverse events. GSK3532795 demonstrated potent antiviral activity against subtype B (monotherapy or with ATV ± RTV) and subtype C, and was generally well tolerated, which supported continued development of GSK3532795 in subjects with HIV-1 subtype B or subtype C. NCT01803074. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

Temperature variability during delirium in ICU patients: an observational study.

PubMed

van der Kooi, Arendina W; Kappen, Teus H; Raijmakers, Rosa J; Zaal, Irene J; Slooter, Arjen J C

2013-01-01

Delirium is an acute disturbance of consciousness and cognition. It is a common disorder in the intensive care unit (ICU) and associated with impaired long-term outcome. Despite its frequency and impact, delirium is poorly recognized by ICU-physicians and -nurses using delirium screening tools. A completely new approach to detect delirium is to use monitoring of physiological alterations. Temperature variability, a measure for temperature regulation, could be an interesting component to monitor delirium, but whether temperature regulation is different during ICU delirium has not yet been investigated. The aim of this study was to investigate whether ICU delirium is related to temperature variability. Furthermore, we investigated whether ICU delirium is related to absolute body temperature. We included patients who experienced both delirium and delirium free days during ICU stay, based on the Confusion Assessment method for the ICU conducted by a research- physician or -nurse, in combination with inspection of medical records. We excluded patients with conditions affecting thermal regulation or therapies affecting body temperature. Daily temperature variability was determined by computing the mean absolute second derivative of the temperature signal. Temperature variability (primary outcome) and absolute body temperature (secondary outcome) were compared between delirium- and non-delirium days with a linear mixed model and adjusted for daily mean Richmond Agitation and Sedation Scale scores and daily maximum Sequential Organ Failure Assessment scores. Temperature variability was increased during delirium-days compared to days without delirium (β(unadjuste)d=0.007, 95% confidence interval (CI)=0.004 to 0.011, p<0.001). Adjustment for confounders did not alter this result (β(adjusted)=0.005, 95% CI=0.002 to 0.008, p<0.001). Delirium was not associated with absolute body temperature (β(unadjusted)=-0.03, 95% CI=-0.17 to 0.10, p=0.61). This did not change after adjusting for confounders (β(adjusted)=-0.03, 95% CI=-0.17 to 0.10, p=0.63). Our study suggests that temperature variability is increased during ICU delirium.

[Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: a randomized controlled trial].

PubMed

Cai, Jun; Wang, Hua; Zhou, Sheng; Wu, Bin; Song, Hua-Rong; Xuan, Zheng-Rong

2008-01-01

To observe the effect of perioperative application of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation. In this prospective, single-blinded, controlled clinical trial, fifty-nine patients with gastric cancer were randomly divided into three groups: control group (n=20) and two study groups (group A, n=21; group B, n=18). Sjunzi Decoction (100 ml) was administered via nasogastric tube to the patients in the study group B from the second postoperation day to the 9th postoperation day. Patients in the two study groups were given an isocaloric and isonitrogonous enteral diet, which was started on the second day after operation, and continued for eight days. Patients in the control group were given an isocaloric and isonitrogonous parenteral diet for 9 days. All variables of nutritional status such as serum albumin (ALB), prealbumin (PA), transferrin (TRF) and T-cell subsets were measured one day before operation, and one day and 10 days after operation. All the nutritional variables and the levels of CD3(+), CD4(+), CD4(+)/CD8(+) were decreased significantly after operation. Ten days after operation, T-cell subsets and nutritional variables in the two study groups were increased as compare with the control group. The levels of ALB, TRF and T-cell subsets in the study group B were increased significantly as compared with the study group A (P<0.05). Enteral nutrition assisted with Sijunzi Decoction can positively improve and optimize cellular immune function and nutritional status in the patients with gastric cancer after operation.

A Systematic Search for Short-term Variability of EGRET Sources

NASA Technical Reports Server (NTRS)

Wallace, P. M.; Griffis, N. J.; Bertsch, D. L.; Hartman, R. C.; Thompson, D. J.; Kniffen, D. A.; Bloom, S. D.

2000-01-01

The 3rd EGRET Catalog of High-energy Gamma-ray Sources contains 170 unidentified sources, and there is great interest in the nature of these sources. One means of determining source class is the study of flux variability on time scales of days; pulsars are believed to be stable on these time scales while blazers are known to be highly variable. In addition, previous work has demonstrated that 3EG J0241-6103 and 3EG J1837-0606 are candidates for a new gamma-ray source class. These sources near the Galactic plane display transient behavior but cannot be associated with any known blazers. Although, many instances of flaring AGN have been reported, the EGRET database has not been systematically searched for occurrences of short-timescale (approximately 1 day) variability. These considerations have led us to conduct a systematic search for short-term variability in EGRET data, covering all viewing periods through proposal cycle 4. Six 3EG catalog sources are reported here to display variability on short time scales; four of them are unidentified. In addition, three non-catalog variable sources are discussed.

The Importance of Postural Control in Relation to Technical Abilities in Small-Sided Soccer Games

PubMed Central

Edis, Çağlar; Vurgun, Hikmet

2016-01-01

Abstract Making assessments regarding postural control and balance is very important for injury prevention in soccer. However, there has been no study that has associated postural control variables with branch-specific technical properties in a game. The aim of the present study was to determine the relationships between variables designating postural control levels and technical performance variables in different (1:1, 2:2 and 3:3) small-sided games (SSGs). Sixteen trained male amateur soccer players volunteered to take part in the study (age 17.2 ± 1.02 years, body height 176.25 ± 0.07 m, body mass 67.67 ± 13.27 kg). Following familiarization sessions, postural control was evaluated using one-leg and both-leg quiet-stance positions by measuring postural sway with a Tekscan HR Mat™ in anterior–posterior and medial–lateral directions. Later, 1:1, 2:2 and 3:3 SSGs were performed at two-day intervals and the technical variables specified for each game were analyzed. A Spearman’s rank-order correlation analysis demonstrated the relationship between postural control and soccer-specific technical variables in 1:1 (r-values ranging from 0.582 to 0.776), 2:2 (rvalues ranging from 0.511 to 0.740) and 3:3 (r-values ranging from 0.502 to 0.834) SSGs. In addition, a Wilcoxon signed rank test revealed differences between SSGs in terms of several variables. The results of the study showed that higher postural control levels are among the important variables that affect success in the performance of technical skills under rival pressure and suddenly changing conditions. Therefore, it is recommended that in addition to its use for injury prevention purposes, balance training should be conducted to improve branch-specific technical skills and to increase the levels of their successful performance in a game. PMID:28149410

The Importance of Postural Control in Relation to Technical Abilities in Small-Sided Soccer Games.

PubMed

Edis, Çağlar; Vural, Faik; Vurgun, Hikmet

2016-12-01

Making assessments regarding postural control and balance is very important for injury prevention in soccer. However, there has been no study that has associated postural control variables with branch-specific technical properties in a game. The aim of the present study was to determine the relationships between variables designating postural control levels and technical performance variables in different (1:1, 2:2 and 3:3) small-sided games (SSGs). Sixteen trained male amateur soccer players volunteered to take part in the study (age 17.2 ± 1.02 years, body height 176.25 ± 0.07 m, body mass 67.67 ± 13.27 kg). Following familiarization sessions, postural control was evaluated using one-leg and both-leg quiet-stance positions by measuring postural sway with a Tekscan HR Mat™ in anterior-posterior and medial-lateral directions. Later, 1:1, 2:2 and 3:3 SSGs were performed at two-day intervals and the technical variables specified for each game were analyzed. A Spearman's rank-order correlation analysis demonstrated the relationship between postural control and soccer-specific technical variables in 1:1 (r-values ranging from 0.582 to 0.776), 2:2 (rvalues ranging from 0.511 to 0.740) and 3:3 (r-values ranging from 0.502 to 0.834) SSGs. In addition, a Wilcoxon signed rank test revealed differences between SSGs in terms of several variables. The results of the study showed that higher postural control levels are among the important variables that affect success in the performance of technical skills under rival pressure and suddenly changing conditions. Therefore, it is recommended that in addition to its use for injury prevention purposes, balance training should be conducted to improve branch-specific technical skills and to increase the levels of their successful performance in a game.

Decision tree analysis of factors influencing rainfall-related building damage

NASA Astrophysics Data System (ADS)

Spekkers, M. H.; Kok, M.; Clemens, F. H. L. R.; ten Veldhuis, J. A. E.

2014-04-01

Flood damage prediction models are essential building blocks in flood risk assessments. Little research has been dedicated so far to damage of small-scale urban floods caused by heavy rainfall, while there is a need for reliable damage models for this flood type among insurers and water authorities. The aim of this paper is to investigate a wide range of damage-influencing factors and their relationships with rainfall-related damage, using decision tree analysis. For this, district-aggregated claim data from private property insurance companies in the Netherlands were analysed, for the period of 1998-2011. The databases include claims of water-related damage, for example, damages related to rainwater intrusion through roofs and pluvial flood water entering buildings at ground floor. Response variables being modelled are average claim size and claim frequency, per district per day. The set of predictors include rainfall-related variables derived from weather radar images, topographic variables from a digital terrain model, building-related variables and socioeconomic indicators of households. Analyses were made separately for property and content damage claim data. Results of decision tree analysis show that claim frequency is most strongly associated with maximum hourly rainfall intensity, followed by real estate value, ground floor area, household income, season (property data only), buildings age (property data only), ownership structure (content data only) and fraction of low-rise buildings (content data only). It was not possible to develop statistically acceptable trees for average claim size, which suggest that variability in average claim size is related to explanatory variables that cannot be defined at the district scale. Cross-validation results show that decision trees were able to predict 22-26% of variance in claim frequency, which is considerably better compared to results from global multiple regression models (11-18% of variance explained). Still, a large part of the variance in claim frequency is left unexplained, which is likely to be caused by variations in data at subdistrict scale and missing explanatory variables.

Helping Children Love Themselves and Others: A Professional Handbook for Family Day Care.

ERIC Educational Resources Information Center

Children's Foundation, Washington, DC.

An anti-bias, multicultural approach to family day care is presented in this book. Part A provides a rationale for such an approach; Part B outlines ideas for children's anti-bias, multicultural projects; Part C describes children's books and adult resources, and lists sources of hard-to-find items such as multicultural dolls and puppets.…

Interrogation of duplicitous stars with an APT

NASA Technical Reports Server (NTRS)

Bopp, Bernard W.

1992-01-01

Preliminary results from intensive spectroscopic and APT monitoring of two interacting binary systems are presented. Both V644 Mon (Be + K:) and HD 37453 (F5 II + B) show complex, composite, and variable spectral. APT observations extending over three years show both stars to vary by 0.1-0.2 mag in V. The photometric variability of V644 Mon appears to be irregular, though there is some evidence for periodic behavior in the 50-60 day range. HD 37453 has an orbital period of 66.75 days; the best-fit photometric period is not quite half this value, indicating the star is an ellipsoidal variable.

Determining the Ocean's Role on the Variable Gravity Field on Earth Rotation

NASA Technical Reports Server (NTRS)

Ponte, Rui M.

1999-01-01

A number of ocean models of different complexity have been used to study changes in the oceanic mass field and angular momentum and their relation to the variable Earth rotation and gravity field. Time scales examined range from seasonal to a few days. Results point to the importance of oceanic signals in driving polar motion, in particular the Chandler and annual wobbles. Results also show that oceanic signals have a measurable impact on length-of-day variations. Various circulation features and associated mass signals, including the North Pacific subtropical gyre, the equatorial currents, and the Antarctic Circumpolar Current play a significant role in oceanic angular momentum variability.

Influence of the two distinct boreal summer intraseasonal oscillation modes on extreme rainfall and heat wave occurrence in the Northern Hemisphere

NASA Astrophysics Data System (ADS)

Lee, J. Y.; Hsu, P. C.; Ha, K. J.; Tsou, C. H.

2016-12-01

How boreal summer intraseasonal oscillation (BSISO) modulates the probability and spatial distributions of extreme rainfall and heat wave occurrence in the Northern Hemisphere (NH) is examined by utilizing the real-time multivariate BSISO indices recently proposed. The BSISO1 represents the canonical northward propagating variability that often occurs in conjunction with the eastward propagating Madden-Julian Oscillation with quasi-oscillating periods of 30-60 days. The BSISO2 represents the northward/northwestward propagating variability with periods of 10-30 days during primarily the pre-monsoon and monsoon-onset season. The BSISO1 circulation cells are more Rossby wave like with a northwest to southeast slope, whereas the circulation associated with the BSISO2 is more elongated and front-like with a southwest to northeast slope. We show that the two distinct BSISO modes have strong impacts on extreme weather events in many parts of the NH depending on region and their phases for the last three decades. Although the BSISO-related convective signals tend to be weakened after reaching mid-latitude, the corresponding atmospheric circulation anomalies remain significant and propagate globally thus exerting global impacts. To better understand the linkage between the BSISO and extreme weather occurrence, we further investigate physical processes contributing to heat wave occurrence in association with the BSISO modes particularly over the four key regions that are central India (CI), Yangtze River valley (YR) in China, Japan, and Korean Peninsula (KP). It is found that a significant increase in heat wave occurrence over CI (YR) is observed during phases 2-3 (8-1) of BSISO2 when the 10-30-day anticyclonic and descending anomaly induces enhanced upward thermal heating and sensible heat flux (warm advection) around the areas. On the other hand, the northeastward propagating BSISO1 is closely connected to the increased heat wave probability over JP and KP. During phases 7-8 of BSISO1, the 30-60-day subsidence along with the low-level anticyclonic anomaly moves into Northeast Asia, leading enhanced diabatic (adiabatic) warming near surface in JP (KP).

Correlates of sedentary time in children: a multilevel modelling approach.

PubMed

Gomes, Thayse Natacha; dos Santos, Fernanda Karina; Santos, Daniel; Pereira, Sara; Chaves, Raquel; Katzmarzyk, Peter Todd; Maia, José

2014-08-30

Sedentary behaviour (SB) has been implicated as a potential risk factor for chronic disease. Since children spend most of their awake time in schools, this study aimed to identify individual- and school-level correlates of sedentary time using a multilevel approach, and to determine if these correlates have a similar effect in normal weight (NW) and overweight/obese (O/O) children. Sample comprised 686 Portuguese children aged 9-10 years from 23 schools that took part in the ISCOLE project. Actigraph GT3X + accelerometers were used 24 hours/day for 7 days to assess sedentary time (daily minutes <100 counts/min); BMI was computed and WHO cut-points were used to classify subjects as NW or O/O. Sex, BMI, number of siblings, family income, computer use on school days, and sleep time on school days were used as individual-level correlates. At the school level, school size (number of students), percentage of students involved in sports or physical activity (PA) clubs, school promotion of active transportation, and students' access to equipment outside school hours were used. All multilevel modelling analysis was done in SPSS, WINPEPI, and HLM. School-level correlates explain ≈ 6.0% of the total variance in sedentary time. Results (β ± SE) showed that boys (-30.85 ± 5.23), children with more siblings (-8.56 ± 2.71) and those who sleep more (-17.78 ± 3.06) were less sedentary, while children with higher family income were more sedentary (4.32 ± 1.68). At the school level, no variable was significantly correlated with sedentary time. Among weight groups, variables related to sedentary time in NW were sex, sleep time and family income, while in O/O sex, number of siblings and sleep time were significant correlates. No school-level predictors were significantly associated in either of the weight groups. Notwithstanding the relevance of the school environment in the reduction of children's sedentary time, individual and family characteristics played a more relevant role than the school context in this study.

Numerical simulation of the 6 day wave effects on the ionosphere: Dynamo modulation

NASA Astrophysics Data System (ADS)

Gan, Quan; Wang, Wenbing; Yue, Jia; Liu, Hanli; Chang, Loren C.; Zhang, Shaodong; Burns, Alan; Du, Jian

2016-10-01

The Thermosphere-Ionosphere-Mesosphere Electrodynamics General Circulation Model (TIME-GCM) is used to theoretically study the 6 day wave effects on the ionosphere. By introducing a 6 day perturbation with zonal wave number 1 at the model lower boundary, the TIME-GCM reasonably reproduces the 6 day wave in temperature and horizontal winds in the mesosphere and lower thermosphere region during the vernal equinox. The E region wind dynamo exhibits a prominent 6 day oscillation that is directly modulated by the 6 day wave. Meanwhile, significant local time variability (diurnal and semidiurnal) is also seen in wind dynamo as a result of altered tides due to the nonlinear interaction between the 6 day wave and migrating tides. More importantly, the perturbations in the E region neutral winds (both the 6 day oscillation and tidal-induced short-term variability) modulate the polarization electric fields, thus leading to the perturbations in vertical ion drifts and ionospheric F2 region peak electron density (NmF2). Our modeling work shows that the 6 day wave couples with the ionosphere via both the direct neutral wind modulation and the interaction with atmospheric tides.

Cortisol and progestin release, heart rate and heart rate variability in the pregnant and postpartum mare, fetus and newborn foal.

PubMed

Nagel, C; Erber, R; Bergmaier, C; Wulf, M; Aurich, J; Möstl, E; Aurich, C

2012-09-01

The mechanisms leading to parturition in the horse in many aspects differ from those in other species. Pregnancy is maintained not by progesterone but by 5α-pregnanes and the progestin precursor pregnenolone originates from the fetus. As parturition approaches, the fetal adrenal switches from pregnenolone to cortisol synthesis but it is not known whether cortisol crosses the placenta. We hypothesized that in parallel to fetal cortisol release, cortisol in the maternal circulation increases before foaling and this increase can be determined in both saliva and plasma. In addition, maternal, fetal and neonatal heart rate and heart rate variability were measured. In 25 pregnant mares, saliva for cortisol analysis was collected 4 times daily from 15 days before to 5 days after foaling. In 13 mares, in addition, fetomaternal electrocardiogram (ECG) recordings were made and blood samples for progestin and cortisol analysis were collected once daily. Heart rate (HR) was recorded until 5 days after foaling. The heart rate variability (HRV) variables standard deviation of the beat-to-beat (RR) interval (SDRR) and root mean square of successive RR differences (RMSSD) were calculated. From Days 15 to 4 before parturition, progestin concentration increased (peak 267 ± 42 ng/mL) and decreased thereafter (P < 0.05, day of foaling 113 ± 18 ng/mL). A prepartum increase in maternal cortisol concentrations was evident in blood (P < 0.05) and saliva (P < 0.05) and paralleled the decrease in progestin concentrations. In mares, HR remained constant during the last days of pregnancy but decreased within one day after parturition (P < 0.05) while maternal HRV did not change. In the fetus and neonate, HR increased from before to after birth (P < 0.05) indicating increasing demands on the cardiovascular system with adaptation to extrauterine life. Copyright © 2012 Elsevier Inc. All rights reserved.

34 CFR 300.11 - Day; business day; school day.

Code of Federal Regulations, 2012 CFR

2012-07-01

... has the same meaning for all children in school, including children with and without disabilities... 34 Education 2 2012-07-01 2012-07-01 false Day; business day; school day. 300.11 Section 300.11... CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.11 Day; business day; school day. (a...

34 CFR 300.11 - Day; business day; school day.

Code of Federal Regulations, 2014 CFR

2014-07-01

... has the same meaning for all children in school, including children with and without disabilities... 34 Education 2 2014-07-01 2013-07-01 true Day; business day; school day. 300.11 Section 300.11... CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.11 Day; business day; school day. (a...

34 CFR 300.11 - Day; business day; school day.

Code of Federal Regulations, 2013 CFR

2013-07-01

... has the same meaning for all children in school, including children with and without disabilities... 34 Education 2 2013-07-01 2013-07-01 false Day; business day; school day. 300.11 Section 300.11... CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.11 Day; business day; school day. (a...

Receiver Operating Characteristic Curve Analysis of Beach Water Quality Indicator Variables

PubMed Central

Morrison, Ann Michelle; Coughlin, Kelly; Shine, James P.; Coull, Brent A.; Rex, Andrea C.

2003-01-01

Receiver operating characteristic (ROC) curve analysis is a simple and effective means to compare the accuracies of indicator variables of bacterial beach water quality. The indicator variables examined in this study were previous day's Enterococcus density and antecedent rainfall at 24, 48, and 96 h. Daily Enterococcus densities and 15-min rainfall values were collected during a 5-year (1996 to 2000) study of four Boston Harbor beaches. The indicator variables were assessed for their ability to correctly classify water as suitable or unsuitable for swimming at a maximum threshold Enterococcus density of 104 CFU/100 ml. Sensitivity and specificity values were determined for each unique previous day's Enterococcus density and antecedent rainfall volume and used to construct ROC curves. The area under the ROC curve was used to compare the accuracies of the indicator variables. Twenty-four-hour antecedent rainfall classified elevated Enterococcus densities more accurately than previous day's Enterococcus density (P = 0.079). An empirically derived threshold for 48-h antecedent rainfall, corresponding to a sensitivity of 0.75, was determined from the 1996 to 2000 data and evaluated to ascertain if the threshold would produce a 0.75 sensitivity with independent water quality data collected in 2001 from the same beaches. PMID:14602593

Prediction of the birch pollen season characteristics in Cracow, Poland using an 18-year data series.

PubMed

Dorota, Myszkowska

2013-03-01

The aim of the study was to construct the model forecasting the birch pollen season characteristics in Cracow on the basis of an 18-year data series. The study was performed using the volumetric method (Lanzoni/Burkard trap). The 98/95 % method was used to calculate the pollen season. The Spearman's correlation test was applied to find the relationship between the meteorological parameters and pollen season characteristics. To construct the predictive model, the backward stepwise multiple regression analysis was used including the multi-collinearity of variables. The predictive models best fitted the pollen season start and end, especially models containing two independent variables. The peak concentration value was predicted with the higher prediction error. Also the accuracy of the models predicting the pollen season characteristics in 2009 was higher in comparison with 2010. Both, the multi-variable model and one-variable model for the beginning of the pollen season included air temperature during the last 10 days of February, while the multi-variable model also included humidity at the beginning of April. The models forecasting the end of the pollen season were based on temperature in March-April, while the peak day was predicted using the temperature during the last 10 days of March.

Initial fractal exponent of heart-rate variability is associated with success of early resuscitation in patients with severe sepsis or septic shock: a prospective cohort study

PubMed Central

Brown, Samuel M.; Tate, Quinn; Jones, Jason P.; Knox, Daniel; Kuttler, Kathryn G.; Lanspa, Michael; Rondina, Matthew T.; Grissom, Colin K.; Behera, Subhasis; Mathews, V.J.; Morris, Alan

2013-01-01

Introduction Heart-rate variability reflects autonomic nervous system tone as well as the overall health of the baroreflex system. We hypothesized that loss of complexity in heart-rate variability upon ICU admission would be associated with unsuccessful early resuscitation of sepsis. Methods We prospectively enrolled patients admitted to ICUs with severe sepsis or septic shock from 2009 to 2011. We studied 30 minutes of EKG, sampled at 500 Hz, at ICU admission and calculated heart-rate complexity via detrended fluctuation analysis. Primary outcome was vasopressor independence at 24 hours after ICU admission. Secondary outcome was 28-day mortality. Results We studied 48 patients, of whom 60% were vasopressor independent at 24 hours. Five (10%) died within 28 days. The ratio of fractal alpha parameters was associated with both vasopressor independence and 28-day mortality (p=0.04) after controlling for mean heart rate. In the optimal model, SOFA score and the long-term fractal alpha parameter were associated with vasopressor independence. Conclusions Loss of complexity in heart rate variability is associated with worse outcome early in severe sepsis and septic shock. Further work should evaluate whether complexity of heart rate variability (HRV) could guide treatment in sepsis. PMID:23958243

Variability and distribution of spatial evapotranspiration in semi arid Inner Mongolian grasslands from 2002 to 2011.

PubMed

Schaffrath, David; Bernhofer, Christian

2013-01-01

Grasslands in Inner Mongolia are important for livestock farming while ecosystem functioning and water consumption are dominated by evapotranspiration (ET). In this paper we studied the spatiotemporal distribution and variability of ET and its components in Inner Mongolian grasslands over a period of 10 years, from 2002 to 2011. ET was modelled pixel-wise for more than 3000 1 km(2) pixels with the physically-based hydrological model BROOK90. The model was parameterised from eddy-covariance measurements and daily input was generated from MODIS leaf area index and surface temperatures. Modelled ET was also compared with the ET provided by the MODIS MOD16 ET data. The study showed ET to be highly variable in both time and space in Inner Mongolian grasslands. The mean coefficient of variation of 8-day ET in the study area varied between 25% and 40% and was up to 75% for individual pixels indicating a high innerannual variability of ET. Generally, ET equals or exceeds P during the vegetation period, but high precipitation in 2003 clearly exceeded ET in this year indicating a recharge of soil moisture and groundwater. Despite the high interannual and innerannual variations of spatial ET, the study also showed the existence of an intrinsic long-term spatial pattern of ET distribution, which can be explained partly by altitude and longitude (R(2) = 0.49). In conclusion, the results of this research suggest the development of dynamic and productive rangeland management systems according to the inherent variability of rainfall, productivity and ET in order to restore and protect Inner Mongolian grasslands.

Description and validation of the Simple, Efficient, Dynamic, Global, Ecological Simulator (SEDGES v.1.0)

NASA Astrophysics Data System (ADS)

Paiewonsky, Pablo; Elison Timm, Oliver

2018-03-01

In this paper, we present a simple dynamic global vegetation model whose primary intended use is auxiliary to the land-atmosphere coupling scheme of a climate model, particularly one of intermediate complexity. The model simulates and provides important ecological-only variables but also some hydrological and surface energy variables that are typically either simulated by land surface schemes or else used as boundary data input for these schemes. The model formulations and their derivations are presented here, in detail. The model includes some realistic and useful features for its level of complexity, including a photosynthetic dependency on light, full coupling of photosynthesis and transpiration through an interactive canopy resistance, and a soil organic carbon dependence for bare-soil albedo. We evaluate the model's performance by running it as part of a simple land surface scheme that is driven by reanalysis data. The evaluation against observational data includes net primary productivity, leaf area index, surface albedo, and diagnosed variables relevant for the closure of the hydrological cycle. In this setup, we find that the model gives an adequate to good simulation of basic large-scale ecological and hydrological variables. Of the variables analyzed in this paper, gross primary productivity is particularly well simulated. The results also reveal the current limitations of the model. The most significant deficiency is the excessive simulation of evapotranspiration in mid- to high northern latitudes during their winter to spring transition. The model has a relative advantage in situations that require some combination of computational efficiency, model transparency and tractability, and the simulation of the large-scale vegetation and land surface characteristics under non-present-day conditions.

Validation of spatial variability in downscaling results from the VALUE perfect predictor experiment

NASA Astrophysics Data System (ADS)

Widmann, Martin; Bedia, Joaquin; Gutiérrez, Jose Manuel; Maraun, Douglas; Huth, Radan; Fischer, Andreas; Keller, Denise; Hertig, Elke; Vrac, Mathieu; Wibig, Joanna; Pagé, Christian; Cardoso, Rita M.; Soares, Pedro MM; Bosshard, Thomas; Casado, Maria Jesus; Ramos, Petra

2016-04-01

VALUE is an open European network to validate and compare downscaling methods for climate change research. Within VALUE a systematic validation framework to enable the assessment and comparison of both dynamical and statistical downscaling methods has been developed. In the first validation experiment the downscaling methods are validated in a setup with perfect predictors taken from the ERA-interim reanalysis for the period 1997 - 2008. This allows to investigate the isolated skill of downscaling methods without further error contributions from the large-scale predictors. One aspect of the validation is the representation of spatial variability. As part of the VALUE validation we have compared various properties of the spatial variability of downscaled daily temperature and precipitation with the corresponding properties in observations. We have used two test validation datasets, one European-wide set of 86 stations, and one higher-density network of 50 stations in Germany. Here we present results based on three approaches, namely the analysis of i.) correlation matrices, ii.) pairwise joint threshold exceedances, and iii.) regions of similar variability. We summarise the information contained in correlation matrices by calculating the dependence of the correlations on distance and deriving decorrelation lengths, as well as by determining the independent degrees of freedom. Probabilities for joint threshold exceedances and (where appropriate) non-exceedances are calculated for various user-relevant thresholds related for instance to extreme precipitation or frost and heat days. The dependence of these probabilities on distance is again characterised by calculating typical length scales that separate dependent from independent exceedances. Regionalisation is based on rotated Principal Component Analysis. The results indicate which downscaling methods are preferable if the dependency of variability at different locations is relevant for the user.

Data-driven clustering of rain events: microphysics information derived from macro-scale observations

NASA Astrophysics Data System (ADS)

Djallel Dilmi, Mohamed; Mallet, Cécile; Barthes, Laurent; Chazottes, Aymeric

2017-04-01

Rain time series records are generally studied using rainfall rate or accumulation parameters, which are estimated for a fixed duration (typically 1 min, 1 h or 1 day). In this study we use the concept of rain events. The aim of the first part of this paper is to establish a parsimonious characterization of rain events, using a minimal set of variables selected among those normally used for the characterization of these events. A methodology is proposed, based on the combined use of a genetic algorithm (GA) and self-organizing maps (SOMs). It can be advantageous to use an SOM, since it allows a high-dimensional data space to be mapped onto a two-dimensional space while preserving, in an unsupervised manner, most of the information contained in the initial space topology. The 2-D maps obtained in this way allow the relationships between variables to be determined and redundant variables to be removed, thus leading to a minimal subset of variables. We verify that such 2-D maps make it possible to determine the characteristics of all events, on the basis of only five features (the event duration, the peak rain rate, the rain event depth, the standard deviation of the rain rate event and the absolute rain rate variation of the order of 0.5). From this minimal subset of variables, hierarchical cluster analyses were carried out. We show that clustering into two classes allows the conventional convective and stratiform classes to be determined, whereas classification into five classes allows this convective-stratiform classification to be further refined. Finally, our study made it possible to reveal the presence of some specific relationships between these five classes and the microphysics of their associated rain events.

OH and halogen atom influence on the variability of non-methane hydrocarbons in the Antarctic Boundary Layer

NASA Astrophysics Data System (ADS)

Read, Katie A.; Lewis, Alastair C.; Salmon, Rhian A.; Jones, Anna E.; Bauguitte, Stéphane

2007-02-01

Measurements of C2-C8 non-methane hydrocarbons (NMHCs) have been made in situ at Halley Base, Antarctica (75°35'S, 26°19'W) from February 2004 to February 2005 as part of the Chemistry of the Antarctic Boundary Layer and the Interface with Snow (CHABLIS) experiment. The data show long- and short-term variabilities in NMHCs controlled by the seasonal and geographic dependence of emissions and variation in atmospheric removal rates and pathways. Ethane, propane, iso-butane, n-butane and acetylene abundances followed a general OH-dependent sinusoidal seasonal cycle. The yearly averages were 186, 31, 3.2, 4.9 and 19 pptV, respectively, lower than those which were reported in some previous studies. Superimposed on a seasonal cycle was shorter-term variability that could be attributed to both synoptic airmass variability and localized loss processes due to other radical species. Hydrocarbon variability during periods of hour-to-day-long surface O3 depletion in late winter/early spring indicated active halogen atom chemistry estimated to be in the range 1.7 × 103-3.4 × 104 atom cm-3 for Cl and 4.8 × 106-9.6 × 107 atom cm-3 for Br. Longer-term negative deviations from sinusoidal behaviour in the late August were indicative of NMHC reaction with a persistent [Cl] of 2.3 × 103 atom cm-3. Maximum ethene and propene of 157 and 179 pptV, respectively, were observed in the late February/early March, consistent with increased oceanic biogenic emissions; however, their presence was significant year-round (June-August concentrations of 17.1 +/- 18.3 and 7.9 +/- 20.0 pptV, respectively).

Child health surveillance. Surveillance of the child under 5.

PubMed Central

Bantock, H.; Modell, M.

1992-01-01

1. General health checks should be made at the following times as outlined in these guidelines: Initial neonatal assessment 7-10 day check, 6-week check, 7-9 months: general examination with particular attention to hearing and vision, 18-24 months: check with special attention to gait, speech and understanding, 36-42 months: general examination and developmental assessment, 2. Parental concern over a child's special senses should be carefully followed up and investigated. 3. Immunization schedules are as follows: 0-2 months: Neonatal BCG (variable depending upon local public health policy and countries of origin of local residents) 2 months: 1st diphtheria, tetanus, pertussis (DTP) and polio, Hib 3 months: 2nd DTP and polio, Hib 4 months: 3rd DTP and polio, Hib 12-18 months: MMR 4 years: Preschool DT and polio There are very few contra-indications. 4. Failure to thrive may be caused by infection, a metabolic problem or emotional factors. It is most commonly revealed by: poor weight gain over a period of time rapid weight loss. These guidelines are in two parts. The first part outlines a programme of surveillance which we hope all general practitioners will find helpful. The second part is more applicable to practices which organize their own child health clinics. PMID:1285363

Does Stress Result in You Exercising Less? Or Does Exercising Result in You Being Less Stressed? Or Is It Both? Testing the Bi-directional Stress-Exercise Association at the Group and Person (N of 1) Level.

PubMed

Burg, Matthew M; Schwartz, Joseph E; Kronish, Ian M; Diaz, Keith M; Alcantara, Carmela; Duer-Hefele, Joan; Davidson, Karina W

2017-12-01

Psychosocial stress contributes to heart disease in part by adversely affecting maintenance of health behaviors, while exercise can reduce stress. Assessing the bi-directional relationship between stress and exercise has been limited by lack of real-time data and theoretical and statistical models. This lack may hinder efforts to promote exercise maintenance. We test the bi-directional relationship between stress and exercise using real-time data for the average person and the variability-individual differences-in this relationship. An observational study was conducted within a single cohort randomized controlled experiment. Healthy young adults, (n = 79) who reported only intermittent exercise, completed 12 months of stress monitoring by ecological momentary assessment (at the beginning of, end of, and during the day) and continuous activity monitoring by Fitbit. A random coefficients linear mixed model was used to predict end-of-day stress from the occurrence/non-occurrence of exercise that day; a logistic mixed model was used to predict the occurrence/non-occurrence of exercise from ratings of anticipated stress. Separate regression analyses were also performed for each participant. Sensitivity analysis tested all models, restricted to the first 180 days of observation (prior to randomization). We found a significant average inverse (i.e., negative) effect of exercise on stress and of stress on exercise. There was significant between-person variability. Of N = 69, exercise was associated with a stress reduction for 15, a stress increase for 2, and no change for the remainder. We also found that an increase in anticipated stress reported the previous night or that morning was associated with a significant 20-22% decrease (OR = 0.78-0.80) in the odds of exercising that day. Of N = 69, this increase in stress reduced the likelihood of exercise for 17, increased the odds for 1, and had no effect for the remainder. We were unable to identify psychosocial factors that moderate the individual differences in these effects. The relationship of stress to exercise can be uni- or bi-directional and varies from person to person. A precision medicine approach may improve exercise uptake.