Sample records for death linking sister

  1. Siblings' experiences of their brother's or sister's cancer death: a nationwide follow-up 2-9 years later.

    PubMed

    Lövgren, Malin; Jalmsell, Li; Eilegård Wallin, Alexandra; Steineck, Gunnar; Kreicbergs, Ulrika

    2016-04-01

    The aim of this study was to examine siblings' experiences of their brother's or sister's cancer death and if these experiences influenced levels of anxiety 2-9 years later. This nationwide survey was conducted in Sweden in 2009. All siblings who had a brother/sister who was diagnosed with cancer before the age of 17 years and who died before the age of 25 years during 2000-2007 were invited. Of those, 174 siblings participated (participation rate: 73%). Mixed data from the survey about the siblings' experiences of death were included as well as data from the Hospital Anxiety and Depression Scale. To examine the experiences, descriptive statistics and content analysis were used. Mann-Whitney U-test was conducted to investigate if the experiences influenced anxiety 2-9 years later. The siblings reported poor knowledge and experienced a lack of communication about their brother's/sister's death, for example, about the time frame, bodily changes near death, and about their own experiences. Siblings who reported that no one talked with them about what to expect when their brother/sister was going to die reported higher levels of anxiety 2-9 years after the loss. Seventy percent reported that they witnessed their brother/sister suffering in the last hours in life. Many of those who were not present during the illness period and at the time of death expressed regret. It is important to prepare siblings for their brother's/sister's illness and death as it may decrease anxiety and regrets later on. Copyright © 2015 John Wiley & Sons, Ltd.

  2. Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores

    PubMed Central

    Kajtez, Janko; Solomatina, Anastasia; Novak, Maja; Polak, Bruno; Vukušić, Kruno; Rüdiger, Jonas; Cojoc, Gheorghe; Milas, Ana; Šumanovac Šestak, Ivana; Risteski, Patrik; Tavano, Federica; Klemm, Anna H.; Roscioli, Emanuele; Welburn, Julie; Cimini, Daniela; Glunčić, Matko; Pavin, Nenad; Tolić, Iva M.

    2016-01-01

    During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed between sister kinetochores, but their function is unknown. Here we show by laser-cutting of a k-fibre in HeLa and PtK1 cells that a bundle of non-kinetochore microtubules, which we term ‘bridging fibre', bridges sister k-fibres and balances the interkinetochore tension. We found PRC1 and EB3 in the bridging fibre, suggesting that it consists of antiparallel dynamic microtubules. By using a theoretical model that includes a bridging fibre, we show that the forces at the pole and at the kinetochore depend on the bridging fibre thickness. Moreover, our theory and experiments show larger relaxation of the interkinetochore distance for cuts closer to kinetochores. We conclude that the bridging fibre, by linking sister k-fibres, withstands the tension between sister kinetochores and enables the spindle to obtain a curved shape. PMID:26728792

  3. Changes in Siblings Over Time After the Death of a Brother or Sister From Cancer.

    PubMed

    Akard, Terrah Foster; Skeens, Micah A; Fortney, Christine A; Dietrich, Mary S; Gilmer, Mary Jo; Vannatta, Kathryn; Barrera, Maru; Davies, Betty; Wray, Sarah; Gerhardt, Cynthia A

    2018-02-27

    Limited research has examined the impact of a child's death from cancer on siblings. Even less is known about how these siblings change over time. This study compared changes in siblings 1 (T1) and 2 (T2) years after the death of a brother or sister from cancer based on bereaved parent and sibling interviews. Participants across 3 institutions represented 27 families and included bereaved mothers (n = 21), fathers (n = 15), and siblings (n = 26) ranging from 8 to 17 years old. Participants completed semistructured interviews. Content analysis identified emerging themes and included frequency counts of participant responses. McNemar tests examined differences in the frequency of responses between T1 and T2 data. Participants reported similar types of changes in bereaved siblings at both time points, including changes in sibling relationships, life perspectives, their personal lives, and school performance. A new theme of "openness" emerged at T2. Frequencies of responses differed according to mother, father, or sibling informant. Overall, participants less frequently reported changes at T2 versus T1. Compared with findings in the first year, participants reported greater sibling maturity at follow-up. Overall changes in bereaved siblings continued over 2 years with less frequency over time, with the exception of increases in maturity and openness. Providers can educate parents regarding the impact of death of a brother or sister over time. Nurses can foster open communication in surviving grieving siblings and parents as potential protective factors in families going through their grief.

  4. Sister-sister incest: data from an anonymous computerized survey.

    PubMed

    Stroebel, Sandra S; O'Keefe, Stephen L; Griffee, Karen; Kuo, Shih-Ya; Beard, Keith W; Kommor, Martin J

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using a computer-assisted self-interview. Thirty-one participants were victims of sister-sister incest, 40 were victims of brother-sister incest, 19 were victims of father-daughter incest, 8 were victims of sexual abuse by an adult female (including one mother), and 232 were victims of sexual abuse by an adult male other than their father before reaching 18 years of age. The rest (1,203) served as controls. The victims of sister-sister incest had significantly more problematic outcomes than controls on many measures as adults. Victims of sister-sister incest were more depressed and more likely than controls to be distant from the perpetrator-sister and to have traded sex for money, experienced an unplanned pregnancy, engaged in four different types of masturbation, and engaged in 13 different same-sex behaviors. Our findings were consistent with other reports of early eroticization and persistent hypereroticization of incest victims.

  5. Yeast cohesin complex embraces 2 micron plasmid sisters in a tri-linked catenane complex

    PubMed Central

    Ghosh, Santanu K.; Huang, Chu-Chun; Hajra, Sujata; Jayaram, Makkuni

    2010-01-01

    Sister chromatid cohesion, crucial for faithful segregation of replicated chromosomes in eukaryotes, is mediated by the multi-subunit protein complex cohesin. The Saccharomyces cerevisiae plasmid 2 micron circle mimics chromosomes in assembling cohesin at its partitioning locus. The plasmid is a multi-copy selfish DNA element that resides in the nucleus and propagates itself stably, presumably with assistance from cohesin. In metaphase cell lysates, or fractions enriched for their cohesed state by sedimentation, plasmid molecules are trapped topologically by the protein ring formed by cohesin. They can be released from cohesin’s embrace either by linearizing the DNA or by cleaving a cohesin subunit. Assays using two distinctly tagged cohesin molecules argue against the hand-cuff (an associated pair of monomeric cohesin rings) or the bracelet (a dimeric cohesin ring) model as responsible for establishing plasmid cohesion. Our cumulative results most easily fit a model in which a single monomeric cohesin ring, rather than a series of such rings, conjoins a pair of sister plasmids. These features of plasmid cohesion account for its sister-to-sister mode of segregation by cohesin disassembly during anaphase. The mechanistic similarities of cohesion between mini-chromosome sisters and 2 micron plasmid sisters suggest a potential kinship between the plasmid partitioning locus and centromeres. PMID:19920123

  6. Teenage pregnancy: the impact of maternal adolescent childbearing and older sister's teenage pregnancy on a younger sister.

    PubMed

    Wall-Wieler, Elizabeth; Roos, Leslie L; Nickel, Nathan C

    2016-05-25

    Risk factors for teenage pregnancy are linked to many factors, including a family history of teenage pregnancy. This research examines whether a mother's teenage childbearing or an older sister's teenage pregnancy more strongly predicts teenage pregnancy. This study used linkable administrative databases housed at the Manitoba Centre for Health Policy (MCHP). The original cohort consisted of 17,115 women born in Manitoba between April 1, 1979 and March 31, 1994, who stayed in the province until at least their 20(th) birthday, had at least one older sister, and had no missing values on key variables. Propensity score matching (1:2) was used to create balanced cohorts for two conditional logistic regression models; one examining the impact of an older sister's teenage pregnancy and the other analyzing the effect of the mother's teenage childbearing. The adjusted odds of becoming pregnant between ages 14 and 19 for teens with at least one older sister having a teenage pregnancy were 3.38 (99 % CI 2.77-4.13) times higher than for women whose older sister(s) did not have a teenage pregnancy. Teenage daughters of mothers who had their first child before age 20 had 1.57 (99 % CI 1.30-1.89) times higher odds of pregnancy than those whose mothers had their first child after age 19. Educational achievement was adjusted for in a sub-population examining the odds of pregnancy between ages 16 and 19. After this adjustment, the odds of teenage pregnancy for teens with at least one older sister who had a teenage pregnancy were reduced to 2.48 (99 % CI 2.01-3.06) and the odds of pregnancy for teen daughters of teenage mothers were reduced to 1.39 (99 % CI 1.15-1.68). Although both were significant, the relationship between an older sister's teenage pregnancy and a younger sister's teenage pregnancy is much stronger than that between a mother's teenage childbearing and a younger daughter's teenage pregnancy. This study contributes to understanding of the broader topic "who is

  7. [Florence Nightingale and charity sisters: revisiting the history].

    PubMed

    Padilha, Maria Itayra Coelho de Souza; Mancia, Joel Rolim

    2005-01-01

    This study presents an historical analysis on the links between the nursing practice and the influence received from various religious orders/associations along the times, especially from Saint Vincent Paul's charity sisters. The professional nursing which was pioneered by Florence Nightingale in the XlXth century, was directly influenced by the teachings of love and fraternity. In addition, other contributions from the religious orders/associations were the concepts of altruism, valorization of an adequate environment for the care of patients, and the division of work in nursing. The study shows the influence of Charity Sisters on Florence Nightingale.

  8. BID links ferroptosis to mitochondrial cell death pathways.

    PubMed

    Neitemeier, Sandra; Jelinek, Anja; Laino, Vincenzo; Hoffmann, Lena; Eisenbach, Ina; Eying, Roman; Ganjam, Goutham K; Dolga, Amalia M; Oppermann, Sina; Culmsee, Carsten

    2017-08-01

    Ferroptosis has been defined as an oxidative and iron-dependent pathway of regulated cell death that is distinct from caspase-dependent apoptosis and established pathways of death receptor-mediated regulated necrosis. While emerging evidence linked features of ferroptosis induced e.g. by erastin-mediated inhibition of the X c - system or inhibition of glutathione peroxidase 4 (Gpx4) to an increasing number of oxidative cell death paradigms in cancer cells, neurons or kidney cells, the biochemical pathways of oxidative cell death remained largely unclear. In particular, the role of mitochondrial damage in paradigms of ferroptosis needs further investigation. In the present study, we find that erastin-induced ferroptosis in neuronal cells was accompanied by BID transactivation to mitochondria, loss of mitochondrial membrane potential, enhanced mitochondrial fragmentation and reduced ATP levels. These hallmarks of mitochondrial demise are also established features of oxytosis, a paradigm of cell death induced by X c - inhibition by millimolar concentrations of glutamate. Bid knockout using CRISPR/Cas9 approaches preserved mitochondrial integrity and function, and mediated neuroprotective effects against both, ferroptosis and oxytosis. Furthermore, the BID-inhibitor BI-6c9 inhibited erastin-induced ferroptosis, and, in turn, the ferroptosis inhibitors ferrostatin-1 and liproxstatin-1 prevented mitochondrial dysfunction and cell death in the paradigm of oxytosis. These findings show that mitochondrial transactivation of BID links ferroptosis to mitochondrial damage as the final execution step in this paradigm of oxidative cell death. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  9. Generativity in Elderly Oblate Sisters of Providence.

    PubMed

    Black, Helen K; Hannum, Susan M; Rubinstein, Robert L; de Medeiros, Kate

    2016-06-01

    We explored how generativity and well-being merged in a group of childless older women: African and Hispanic Roman Catholic Religious Sisters, linking two minority identity characteristics. We qualitatively interviewed 8 Oblate Sisters of Providence (OSP), by providing a framework for examining the range of the women's generativity-cultural spheres in which generativity is rooted and outlets for generativity. Early negative experiences, such as fleeing despotism in Haiti and Cuba and racism within the Catholic Church, occurred alongside positive experiences-families who stressed education, and Caucasian Religious who taught children of color. This became a foundation for the Sister's generative commitment. Findings highlight that research gains from a phenomenological understanding of how religious faith promotes generative cognitions and emotions. Findings also reveal that the experiences of a subculture in society-African-American elderly women religious-add to theories and definitions of generativity. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  10. SISTER STUDY

    EPA Science Inventory

    The Sister Study will investigate the role of genetic, environmental, and lifestyle factors on the risk of breast cancer and other diseases in sisters of women with breast cancer. This research study will enroll 50,000 women who live in the United States and who are the cancer-fr...

  11. K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death.

    PubMed

    Seo, Jinho; Lee, Eun-Woo; Shin, Jihye; Seong, Daehyeon; Nam, Young Woo; Jeong, Manhyung; Lee, Seon-Hyeong; Lee, Cheolju; Song, Jaewhan

    2018-05-23

    Fas-associated death domain (FADD) is an adaptor protein recruiting complexes of caspase 8 to death ligand receptors to induce extrinsic apoptotic cell death in response to a TNF superfamily member. Although, formation of the complex of FADD and caspase 8 upon death stimuli has been studied in detail, posttranslational modifications fine-tuning these processes have yet to be identified. Here we revealed that K6-linked polyubiquitylation of FADD on lysines 149 and 153 mediated by C terminus HSC70-interacting protein (CHIP) plays an important role in preventing formation of the death inducing signaling complex (DISC), thus leading to the suppression of cell death. Cells depleted of CHIP showed higher sensitivity toward death ligands such as FasL and TRAIL, leading to upregulation of DISC formation composed of a death receptor, FADD, and caspase 8. CHIP was able to bind to FADD, induce K6-linked polyubiquitylation of FADD, and suppress DISC formation. By mass spectrometry, lysines 149 and 153 of FADD were found to be responsible for CHIP-mediated FADD ubiquitylation. FADD mutated at these sites was capable of more potent cell death induction as compared with the wild type and was no longer suppressed by CHIP. On the other hand, CHIP deficient in E3 ligase activity was not capable of suppressing FADD function and of FADD ubiquitylation. CHIP depletion in ME-180 cells induced significant sensitization of these cells toward TRAIL in xenograft analyses. These results imply that K6-linked ubiquitylation of FADD by CHIP is a crucial checkpoint in cytokine-dependent extrinsic apoptosis.

  12. Mechanics of Sister Chromatids studied with a Polymer Model English</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhang, Yang; Isbaner, Sebastian; Heermann, Dieter</p> <p>2013-10-01</p> <p><span class="hlt">Sister</span> chromatid cohesion denotes the phenomenon that <span class="hlt">sister</span> chromatids are initially attached to each other in mitosis to guarantee the error-free distribution into the daughter cells. Cohesion is mediated by binding proteins and only resolved after mitotic chromosome condensation is completed. However, the amount of attachement points required to maintain <span class="hlt">sister</span> chromatid cohesion while still allowing proper chromosome condensation is not known yet. Additionally the impact of cohesion on the mechanical properties of chromosomes also poses an interesting problem. In this work we study the conformational and mechanical properties of <span class="hlt">sister</span> chromatids by means of computer simulations. We model both protein-mediated cohesion between <span class="hlt">sister</span> chromatids and chromosome condensation with a dynamic binding mechanisms. We show in a phase diagram that only specific <span class="hlt">link</span> concentrations lead to connected and fully condensed chromatids that do not intermingle with each other nor separate due to entropic forces. Furthermore we show that dynamic bonding between chromatids decrease the Young's modulus compared to non-bonded chromatids.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4873764','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4873764"><span>Generativity in Elderly Oblate <span class="hlt">Sisters</span> of Providence</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Black, Helen K.; Hannum, Susan M.; Rubinstein, Robert L.; de Medeiros, Kate</p> <p>2016-01-01</p> <p>Purpose of the Study: We explored how generativity and well-being merged in a group of childless older women: African and Hispanic Roman Catholic Religious <span class="hlt">Sisters</span>, <span class="hlt">linking</span> two minority identity characteristics. Design and Methods: We qualitatively interviewed 8 Oblate <span class="hlt">Sisters</span> of Providence (OSP), by providing a framework for examining the range of the women’s generativity—cultural spheres in which generativity is rooted and outlets for generativity. Results: Early negative experiences, such as fleeing despotism in Haiti and Cuba and racism within the Catholic Church, occurred alongside positive experiences—families who stressed education, and Caucasian Religious who taught children of color. This became a foundation for the Sister’s generative commitment. Implications: Findings highlight that research gains from a phenomenological understanding of how religious faith promotes generative cognitions and emotions. Findings also reveal that the experiences of a subculture in society—African-American elderly women religious—add to theories and definitions of generativity. PMID:25352535</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/254378-two-sisters-clinical-diagnosis-wiskott-aldrich-syndrome-condition-family-autosomal-recessive','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/254378-two-sisters-clinical-diagnosis-wiskott-aldrich-syndrome-condition-family-autosomal-recessive"><span>Two <span class="hlt">sisters</span> with clinical diagnosis of Wiskott-Aldrich Syndrome: Is the condition in the family autosomal recessive?</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Kondoh, T.; Hayashi, K.; Matsumoto, T.</p> <p>1995-10-09</p> <p>We report two <span class="hlt">sisters</span> in a family representing manifestations of Wiskott-Aldrich syndrome (WAS), an X-<span class="hlt">linked</span> immunodeficiency disorder. An elder <span class="hlt">sister</span> had suffered from recurrent infections, small thrombocytopenic petechiae, purpura, and eczema for 7 years. The younger <span class="hlt">sister</span> had the same manifestations as the elder <span class="hlt">sister`s</span> for a 2-year period, and died of intracranial bleeding at age 2 years. All the laboratory data of the two patients were compatible with WAS, although they were females. Sialophorin analysis with the selective radioactive labeling method of this protein revealed that in the elder <span class="hlt">sister</span> a 115-KD band that should be specific for sialophorinmore » was reduced in quantity, and instead an additional 135-KD fragment was present as a main band. Polymerase chain reaction (PCR) analysis of the sialophorin gene and single-strand conformation polymorphism (SSCP) analysis of the PCR product demonstrated that there were no detectable size-change nor electrophoretic mobility change in the DNA from both patients. The results indicated that their sialophorin gene structure might be normal. Studies on the mother-daughter transmission of X chromosome using a pERT84-MaeIII polymorphic marker mapped at Xp21 and HPRT gene polymorphism at Xq26 suggested that each <span class="hlt">sister</span> had inherited a different X chromosome from the mother. Two explanations are plausible for the occurrence of the WAS in our patients: the WAS in the patients is attributable to an autosomal gene mutation which may regulate the sialophorin gene expression through the WAS gene, or, alternatively, the condition in this family is an autosomal recessive disorder separated etiologically from the X-<span class="hlt">linked</span> WAS. 17 refs., 6 figs., 1 tab.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9113588','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9113588"><span>Pregnant and parenting adolescents and their younger <span class="hlt">sisters</span>: the influence of relationship qualities for younger <span class="hlt">sister</span> outcomes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>East, P L; Shi, C R</p> <p>1997-04-01</p> <p>On the basis of social modeling theory and a sibling interaction hypothesis, it was hypothesized that specific relationship qualities between a pregnant or parenting teen and her younger <span class="hlt">sister</span> would be associated with permissive younger <span class="hlt">sister</span> outcomes, such as permissive childbearing attitudes and permissive sexual behavior. Results indicated that negative relationship qualities, such as rivalry, competition, and conflict, were more closely related to younger <span class="hlt">sisters</span> engaging in problem delinquent-like behavior and sexual behavior than were positive relationship qualities, such as warmth and closeness. Additionally, a shared friendship network with the older <span class="hlt">sister</span> was found to be associated with extensive younger <span class="hlt">sister</span> problem behavior and sexual behavior. Three potential explanatory processes are discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3003188','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3003188"><span><span class="hlt">Sister</span> acts: coordinating DNA replication and cohesion establishment</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sherwood, Rebecca; Takahashi, Tatsuro S.; Jallepalli, Prasad V.</p> <p>2010-01-01</p> <p>The ring-shaped cohesin complex <span class="hlt">links</span> <span class="hlt">sister</span> chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated. PMID:21159813</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=317234','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=317234"><span>Faithful anaphase is ensured by Mis4, a <span class="hlt">sister</span> chromatid cohesion molecule required in S phase and not destroyed in G1 phase</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Furuya, Kanji; Takahashi, Kohta; Yanagida, Mitsuhiro</p> <p>1998-01-01</p> <p>The loss of <span class="hlt">sister</span> chromatid cohesion triggers anaphase spindle movement. The budding yeast Mcd1/Scc1 protein, called cohesin, is required for associating chromatids, and proteins homologous to it exist in a variety of eukaryotes. Mcd1/Scc1 is removed from chromosomes in anaphase and degrades in G1. We show that the fission yeast protein, Mis4, which is required for equal <span class="hlt">sister</span> chromatid separation in anaphase is a different chromatid cohesion molecule that behaves independent of cohesin and is conserved from yeast to human. Its inactivation in G1 results in cell lethality in S phase and subsequent premature <span class="hlt">sister</span> chromatid separation. Inactivation in G2 leads to cell <span class="hlt">death</span> in subsequent metaphase–anaphase progression but missegregation occurs only in the next round of mitosis. Mis4 is not essential for condensation, nor does it degrade in G1. Rather, it associates with chromosomes in a punctate fashion throughout the cell cycle. mis4 mutants are hypersensitive to hydroxyurea (HU) and UV irradiation but retain the ability to restrain cell cycle progression when damaged or sustaining a block to replication. The mis4 mutation results in synthetic lethality with a DNA ligase mutant. Mis4 may form a stable <span class="hlt">link</span> between chromatids in S phase that is split rather than removed in anaphase. PMID:9808627</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70013469','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70013469"><span>THREE <span class="hlt">SISTERS</span> WILDERNESS, OREGON.</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>MacLeod, Norman S.; Causey, J. Douglas</p> <p>1984-01-01</p> <p>A mineral survey of the Three <span class="hlt">Sisters</span> Wilderness, Oregon indicated little promise for the occcurrence of metallic mineral resources. Block pumice suitable for commercial uses occurs at an undeveloped claim at Rock Mesa in the wilderness, but numerous other sources occur outside the wilderness closer to markets. A broad area centered around South <span class="hlt">Sister</span> volcano is among the most favorable targets for geothermal resources in the Oregon Cascade Range, based on the very young age and large volume of silicic volcanic rocks that occur in this area. Deep exploration holes could be drilled in areas outside the wilderness south of South <span class="hlt">Sister</span> to provide data on the subsurface thermal and hydrologic regimes in the southern part of the area most likely to contain geothermal resources.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=leadership%2bpoverty&pg=4&id=EJ1009515','ERIC'); return false;" href="https://eric.ed.gov/?q=leadership%2bpoverty&pg=4&id=EJ1009515"><span><span class="hlt">Sister</span> R. Leadership: Doing the Seemingly Impossible</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Sena, Rachel; Schoorman, Dilys; Bogotch, Ira</p> <p>2013-01-01</p> <p><span class="hlt">Sister</span> R., the first author, is a Dominican <span class="hlt">Sister</span> of Peace. Until recently, <span class="hlt">Sister</span> R. had been the director of the Maya Ministry Family Literacy Program, working with the Maya Community in Lake Worth, Palm Beach County, Florida. She described her work with these indigenous, preliterate, hardworking peoples as "a university of the poor"…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ1081574.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ1081574.pdf"><span>A Brief Analysis of <span class="hlt">Sister</span> Carrie's Character</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Yu, Hanying</p> <p>2010-01-01</p> <p>Carrie is always dreaming while the rocking chair is rocking again and again, this is the deep impression on us after we read "<span class="hlt">Sister</span> Carrie" which is the first novel of Theodore Dreiser. In this novel the protagonist <span class="hlt">Sister</span> Carrie is a controversial person. This paper tries to analyze the character of <span class="hlt">Sister</span> Carrie in order to find out…</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li class="active"><span>1</span></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_1 --> <div id="page_2" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_1");'>1</a></li> <li class="active"><span>2</span></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="21"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.fs.usda.gov/treesearch/pubs/31714','TREESEARCH'); return false;" href="https://www.fs.usda.gov/treesearch/pubs/31714"><span><span class="hlt">Linking</span> Shorebird Conservation and Education Along Flyways: An Overview of the Shorebird <span class="hlt">Sister</span> Schools Program</span></a></p> <p><a target="_blank" href="http://www.fs.usda.gov/treesearch/">Treesearch</a></p> <p>Hillary Chapman; Heather Johnson</p> <p>2005-01-01</p> <p>The Shorebird <span class="hlt">Sister</span> Schools Program (SSSP) is an internet-based environmental education program that provides a forum for students, biologists, and shorebird enthusiasts to track shorebird migration and share observations along flyways. The program?s vision is to engage public participation in the conservation of shorebirds and their wetland, grassland, and shoreline...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/2434036','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/2434036"><span>Somatomedin C deficiency in Asian <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McGraw, M E; Price, D A; Hill, D J</p> <p>1986-12-01</p> <p>Two <span class="hlt">sisters</span> of Asian origin showed typical clinical and biochemical features of primary somatomedin C (SM-C) deficiency (Laron dwarfism). Abnormalities of SM-C binding proteins were observed, one <span class="hlt">sister</span> lacking the high molecular weight (150 Kd) protein.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1778201','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1778201"><span>Somatomedin C deficiency in Asian <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>McGraw, M E; Price, D A; Hill, D J</p> <p>1986-01-01</p> <p>Two <span class="hlt">sisters</span> of Asian origin showed typical clinical and biochemical features of primary somatomedin C (SM-C) deficiency (Laron dwarfism). Abnormalities of SM-C binding proteins were observed, one <span class="hlt">sister</span> lacking the high molecular weight (150 Kd) protein. Images Figure PMID:2434036</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28738872','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28738872"><span>A population-based study of homicide <span class="hlt">deaths</span> in Ontario, Canada using <span class="hlt">linked</span> <span class="hlt">death</span> records.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lachaud, James; Donnelly, Peter D; Henry, David; Kornas, Kathy; Calzavara, Andrew; Bornbaum, Catherine; Rosella, Laura</p> <p>2017-07-24</p> <p>Homicide - a lethal expression of violence - has garnered little attention from public health researchers and health policy makers, despite the fact that homicides are a cause of preventable and premature <span class="hlt">death</span>. Identifying populations at risk and the upstream determinants of homicide are important for addressing inequalities that hinder population health. This population-based study investigates the public health significance of homicides in Ontario, Canada, over the period of 1999-2012. We quantified the relative burden of homicides by comparing the socioeconomic gradient in homicides with the leading causes of <span class="hlt">death</span>, cardiovascular disease (CVD) and neoplasm, and estimated the potential years of life lost (PYLL) due to homicide. We <span class="hlt">linked</span> vital statistics from the Office of the Registrar General <span class="hlt">Deaths</span> register (ORG-D) with Census and administrative data for all Ontario residents. We extracted all homicide, neoplasm, and cardiovascular <span class="hlt">deaths</span> from 1999 to 2012, using International Classification of Diseases codes. For socioeconomic status (SES), we used two dimensions of the Ontario Marginalization Index (ON-Marg): material deprivation and residential instability. Trends were summarized across deprivation indices using age-specific rates, rate ratios, and PYLL. Young males, 15-29 years old, were the main victims of homicide with a rate of 3.85 [IC 95%: 3.56; 4.13] per 100,000 population and experienced an upward trend over the study period. The socioeconomic neighbourhood gradient was substantial and higher than the gradient for both cardiovascular and neoplasms. Finally, the PYLL due to homicide were 63,512 and 24,066 years for males and females, respectively. Homicides are an important cause of <span class="hlt">death</span> among young males, and populations living in disadvantaged neighbourhoods. Our findings raise concerns about the burden of homicides in the Canadian population and the importance of addressing social determinants to address these premature <span class="hlt">deaths</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70035238','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70035238"><span>Eruptive history of South <span class="hlt">Sister</span>, Oregon Cascades</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Fierstein, J.; Hildreth, W.; Calvert, A.T.</p> <p>2011-01-01</p> <p>South <span class="hlt">Sister</span> is southernmost and highest of the Three <span class="hlt">Sisters</span>, three geologically dissimilar stratovolcanoes that together form a spectacular 20km reach along the Cascade crest in Oregon. North <span class="hlt">Sister</span> is a monotonously mafic edifice as old as middle Pleistocene, Middle <span class="hlt">Sister</span> a basalt-andesite-dacite cone built between 48 and 14ka, and South <span class="hlt">Sister</span> is a basalt-free edifice that alternated rhyolitic and intermediate modes from 50ka to 2ka (largely contemporaneous with Middle <span class="hlt">Sister</span>). Detailed mapping, 330 chemical analyses, and 42 radioisotopic ages show that the oldest exposed South <span class="hlt">Sister</span> lavas were initially rhyolitic ~50ka. By ~37ka, rhyolitic lava flows and domes (72-74% SiO2) began alternating with radially emplaced dacite (63-68% SiO2) and andesite (59-63% SiO2) lava flows. Construction of a broad cone of silicic andesite-dacite (61-64% SiO2) culminated ~30ka in a dominantly explosive sequence that began with crater-forming andesitic eruptions that left fragmental deposits at least 200m thick. This was followed at ~27ka by growth of a steeply dipping summit cone of agglutinate-dominated andesite (56-60.5% SiO2) and formation of a summit crater ~800m wide. This crater was soon filled and overtopped by a thick dacite lava flow and then by >150m of dacitic pyroclastic ejecta. Small-volume dacite lavas (63-67% SiO2) locally cap the pyroclastic pile. A final sheet of mafic agglutinate (54-56% SiO2) - the most mafic product of South <span class="hlt">Sister</span> - erupted from and drapes the small (300-m-wide) present-day summit crater, ending a summit-building sequence that lasted until ~22ka. A 20kyr-long-hiatus was broken by rhyolite eruptions that produced (1) the Rock Mesa coulee, tephra, and satellite domelets (73.5% SiO2) and (2) the Devils Chain of ~20 domes and short coulees (72.3-72.8% SiO2) from N-S vent alignments on South <span class="hlt">Sister</span>'s flanks. The compositional reversal from mafic summit agglutinate to recent rhyolites epitomizes the frequently changing compositional modes of the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011JVGR..207..145F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011JVGR..207..145F"><span>Eruptive history of South <span class="hlt">Sister</span>, Oregon Cascades</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Fierstein, Judy; Hildreth, Wes; Calvert, Andrew T.</p> <p>2011-10-01</p> <p>South <span class="hlt">Sister</span> is southernmost and highest of the Three <span class="hlt">Sisters</span>, three geologically dissimilar stratovolcanoes that together form a spectacular 20 km reach along the Cascade crest in Oregon. North <span class="hlt">Sister</span> is a monotonously mafic edifice as old as middle Pleistocene, Middle <span class="hlt">Sister</span> a basalt-andesite-dacite cone built between 48 and 14 ka, and South <span class="hlt">Sister</span> is a basalt-free edifice that alternated rhyolitic and intermediate modes from 50 ka to 2 ka (largely contemporaneous with Middle <span class="hlt">Sister</span>). Detailed mapping, 330 chemical analyses, and 42 radioisotopic ages show that the oldest exposed South <span class="hlt">Sister</span> lavas were initially rhyolitic ~ 50 ka. By ~ 37 ka, rhyolitic lava flows and domes (72-74% SiO 2) began alternating with radially emplaced dacite (63-68% SiO 2) and andesite (59-63% SiO 2) lava flows. Construction of a broad cone of silicic andesite-dacite (61-64% SiO 2) culminated ~ 30 ka in a dominantly explosive sequence that began with crater-forming andesitic eruptions that left fragmental deposits at least 200 m thick. This was followed at ~ 27 ka by growth of a steeply dipping summit cone of agglutinate-dominated andesite (56-60.5% SiO 2) and formation of a summit crater ~ 800 m wide. This crater was soon filled and overtopped by a thick dacite lava flow and then by > 150 m of dacitic pyroclastic ejecta. Small-volume dacite lavas (63-67% SiO 2) locally cap the pyroclastic pile. A final sheet of mafic agglutinate (54-56% SiO 2) - the most mafic product of South <span class="hlt">Sister</span> - erupted from and drapes the small (300-m-wide) present-day summit crater, ending a summit-building sequence that lasted until ~ 22 ka. A 20 kyr-long-hiatus was broken by rhyolite eruptions that produced (1) the Rock Mesa coulee, tephra, and satellite domelets (73.5% SiO 2) and (2) the Devils Chain of ~ 20 domes and short coulees (72.3-72.8% SiO 2) from N-S vent alignments on South <span class="hlt">Sister</span>'s flanks. The compositional reversal from mafic summit agglutinate to recent rhyolites epitomizes the frequently</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22074778','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22074778"><span>Climate niches of milkweeds with plesiomorphic traits (Secamonoideae; Apocynaceae) and the milkweed <span class="hlt">sister</span> group <span class="hlt">link</span> ancient African climates and floral evolution.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Livshultz, Tatyana; Mead, Jerry V; Goyder, David J; Brannin, Michelle</p> <p>2011-12-01</p> <p>Climate change that increases mortality of plants and pollinators can create mate-finding Allee effects and thus act as a strong selective force on floral morphology. Milkweeds (Secamonoideae and Asclepiadoideae; Apocynaceae) are typically small plants of seasonally dry habitats, with pollinia and high pollen-transfer efficiency. Their <span class="hlt">sister</span> group (tribe Baisseeae and Dewevrella) is mostly comprised of giant lianas of African rainforests, with pollen in monads. Comparison of the two groups motivated a new hypothesis: milkweeds evolved in the context of African aridification and the shifting of rainforest to dry forest. Pollinia and high pollen-transfer efficiency may have been adaptations that alleviated mate-finding Allee effects generated by high mortality during droughts. We formally tested whether milkweeds have a drier climate niche by comparing milkweeds with plesiomorphic traits (Secamonoideae) and the milkweed <span class="hlt">sister</span> group in continental Africa. We georeferenced specimens of the milkweed <span class="hlt">sister</span> group and Secamonoideae in continental Africa, extracted 19 climatic variables from the Worldclim model, conducted factor analysis to identify correlated suites of variables, and compared the frequency distributions of the two lineages relative to each factor. The distributions of Secamonoideae and the milkweed <span class="hlt">sister</span> group differed significantly relative to four factors, each correlated with a distinct suite of climate parameters: (1) air temperature (Secamonoideae: cooler), (2) total and (3) summer precipitation (Secamonoideae: drier), and (4) temperature seasonality and isothermality (Secamonoideae: more seasonal and less isothermal). Secamonoideae in continental Africa inhabit drier, cooler sites than do the milkweed <span class="hlt">sister</span> group, consistent with a shift from rainforests to dry forests in a cooling climate.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=nun+AND+study&pg=2&id=EJ656516','ERIC'); return false;" href="https://eric.ed.gov/?q=nun+AND+study&pg=2&id=EJ656516"><span>The Lay <span class="hlt">Sister</span> in Educational History and Memory.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Jack, Christine Trimingham</p> <p>2000-01-01</p> <p>Focuses on the construction of lay <span class="hlt">sisters</span> in a religious order and school setting using a poststructuralist orientation. Explains that in the study documents were examined and interviews were conducted with ex-students, choir nuns, and a lay <span class="hlt">sister</span> at a small Catholic girls-preparatory boarding school. Explores the narrative of one lay <span class="hlt">sister</span>.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29783138','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29783138"><span>Is <span class="hlt">death</span> anxiety more closely <span class="hlt">linked</span> with optimism or pessimism among older adults?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Barnett, Michael D; Anderson, Ellen A; Marsden, Arthur D</p> <p>2018-05-18</p> <p>The purpose of this study was to investigate whether <span class="hlt">death</span> anxiety is more closely <span class="hlt">linked</span> with optimism or pessimism among older adults. Participants consisted of community-dwelling older adults (N = 253; 73.1% female) in the southern U.S. Both optimism and pessimism demonstrated a bivariate association with <span class="hlt">death</span> anxiety; however, when considering optimism and pessimism together-and after controlling for age, gender, physical health, and mental health-optimism was not associated with <span class="hlt">death</span> anxiety, while pessimism was associated with higher <span class="hlt">death</span> anxiety. Post hoc analyses found a unique relationship between pessimism and greater fear of the unknown. Perhaps, given the inevitability of <span class="hlt">death</span>, limiting negative expectancies is more salient to <span class="hlt">death</span> anxiety than having positive expectancies, and pessimism may be particularly associated with existential and religious concerns. Copyright © 2018 Elsevier B.V. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3181417','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3181417"><span>Mechanism of cell <span class="hlt">death</span> resulting from DNA interstrand cross-<span class="hlt">linking</span> in mammalian cells</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Osawa, T; Davies, D; Hartley, J A</p> <p>2011-01-01</p> <p>DNA interstrand cross-<span class="hlt">links</span> (ICLs) are critical cytotoxic lesions produced by cancer chemotherapeutic agents such as the nitrogen mustards and platinum drugs; however, the exact mechanism of ICL-induced cell <span class="hlt">death</span> is unclear. Here, we show a novel mechanism of p53-independent apoptotic cell <span class="hlt">death</span> involving prolonged cell-cycle (G2) arrest, ICL repair involving HR, transient mitosis, incomplete cytokinesis, and gross chromosomal abnormalities resulting from ICLs in mammalian cells. This characteristic ‘giant' cell <span class="hlt">death</span>, observed by using time-lapse video microscopy, was reduced in ICL repair ERCC1- and XRCC3-deficient cells. Collectively, the results illustrate the coordination of ICL-induced cellular responses, including cell-cycle arrest, DNA damage repair, and cell <span class="hlt">death</span>. PMID:21814285</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=jealousy&pg=7&id=EJ537653','ERIC'); return false;" href="https://eric.ed.gov/?q=jealousy&pg=7&id=EJ537653"><span>Crocodile Talk: Attributions of Incestuously Abused and Nonabused <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Monahan, Kathleen</p> <p>1997-01-01</p> <p>This qualitative study analyzed the retrospective attributions of adult <span class="hlt">sisters</span> (five abused <span class="hlt">sister</span> dyads, and five abused and nonabused <span class="hlt">sister</span> dyads) who grew up in incestuous families. It examined the attributions of subjects regarding the general sibling group; victim selection and nonselection; and attributions regarding jealousy, protection,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013AGUFMPA53A1906Q','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013AGUFMPA53A1906Q"><span>EarthLabs Meet <span class="hlt">Sister</span> Corita Kent</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Quartini, E.; Ellins, K. K.; Cavitte, M. G.; Thirumalai, K.; Ledley, T. S.; Haddad, N.; Lynds, S. E.</p> <p>2013-12-01</p> <p>The EarthLabs project provides a framework to enhance high school students' climate literacy and awareness of climate change. The project provides climate science curriculum and teacher professional development, followed by research on students' learning as teachers implement EarthLabs climate modules in the classroom. The professional development targets high school teachers whose professional growth is structured around exposure to current climate science research, data observation collection and analysis. During summer workshops in Texas and Mississippi, teachers work through the laboratories, experiments, and hand-on activities developed for their students. In summer 2013, three graduate students from the University of Texas at Austin Institute for Geophysics with expertise in climate science participated in two weeklong workshops. The graduate students partnered with exemplary teacher leaders to provide scientific content and lead the EarthLabs learning activities. As an experiment, we integrated a visit to the Blanton Museum and an associated activity in order to motivate participants to think creatively, as well as analytically, about science. This exercise was inspired by the work and educational philosophy of <span class="hlt">Sister</span> Corita Kent. During the visit to the Blanton Museum, we steered participants towards specific works of art pre-selected to emphasize aspects of the climate of Texas and to draw participants' attention to ways in which artists convey different concepts. For example, artists use of color, lines, and symbols conjure emotional responses to imagery in the viewer. The second part of the exercise asked participants to choose a climate message and to convey this through a collage. We encouraged participants to combine their experience at the museum with examples of <span class="hlt">Sister</span> Corita Kent's artwork. We gave them simple guidelines for the project based on techniques and teaching of <span class="hlt">Sister</span> Corita Kent. Evaluation results reveal that participants enjoyed the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23550483','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23550483"><span>Developing skills in clinical leadership for ward <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fenton, Katherine; Phillips, Natasha</p> <p></p> <p>The Francis report has called for a strengthening of the ward <span class="hlt">sister</span>'s role. It recommends that <span class="hlt">sisters</span> should operate in a supervisory capacity and should not be office bound. Effective ward leadership has been recognised as being vital to high-quality patient care and experience, resource management and interprofessional working. However, there is evidence that ward <span class="hlt">sisters</span> are ill equipped to lead effectively and lack confidence in their ability to do so. University College London Hospitals Foundation Trust has recognised that the job has become almost impossible in increasingly large and complex organisations. Ward <span class="hlt">sisters</span> spend less than 40% of their time on clinical leadership and the trust is undertaking a number of initiatives to support them in this role.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.usgs.gov/of/1999/0437/pdf/of1999-0437.pdf','USGSPUBS'); return false;" href="https://pubs.usgs.gov/of/1999/0437/pdf/of1999-0437.pdf"><span>Volcano hazards in the Three <span class="hlt">Sisters</span> region, Oregon</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Scott, William E.; Iverson, R.M.; Schilling, S.P.; Fisher, B.J.</p> <p>2001-01-01</p> <p>Three <span class="hlt">Sisters</span> is one of three potentially active volcanic centers that lie close to rapidly growing communities and resort areas in Central Oregon. Two types of volcanoes exist in the Three <span class="hlt">Sisters</span> region and each poses distinct hazards to people and property. South <span class="hlt">Sister</span>, Middle <span class="hlt">Sister</span>, and Broken Top, major composite volcanoes clustered near the center of the region, have erupted repeatedly over tens of thousands of years and may erupt explosively in the future. In contrast, mafic volcanoes, which range from small cinder cones to large shield volcanoes like North <span class="hlt">Sister</span> and Belknap Crater, are typically short-lived (weeks to centuries) and erupt less explosively than do composite volcanoes. Hundreds of mafic volcanoes scattered through the Three <span class="hlt">Sisters</span> region are part of a much longer zone along the High Cascades of Oregon in which birth of new mafic volcanoes is possible. This report describes the types of hazardous events that can occur in the Three <span class="hlt">Sisters</span> region and the accompanying volcano-hazard-zonation map outlines areas that could be at risk from such events. Hazardous events include landslides from the steep flanks of large volcanoes and floods, which need not be triggered by eruptions, as well as eruption-triggered events such as fallout of tephra (volcanic ash) and lava flows. A proximal hazard zone roughly 20 kilometers (12 miles) in diameter surrounding the Three <span class="hlt">Sisters</span> and Broken Top could be affected within minutes of the onset of an eruption or large landslide. Distal hazard zones that follow river valleys downstream from the Three <span class="hlt">Sisters</span> and Broken Top could be inundated by lahars (rapid flows of water-laden rock and mud) generated either by melting of snow and ice during eruptions or by large landslides. Slow-moving lava flows could issue from new mafic volcanoes almost anywhere within the region. Fallout of tephra from eruption clouds can affect areas hundreds of kilometers (miles) downwind, so eruptions at volcanoes elsewhere in the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25985782','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25985782"><span>"If I only touch her cloak": the <span class="hlt">Sisters</span> of Charity of St. Joseph in New Orleans hospital, 1834-1860.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kong, Hyejung Grace; Kim, Ock-Joo</p> <p>2015-04-01</p> <p> wearing a distinctive religious garment, they eschewed female dependence and sexuality. As medical and religious attendants at the sick wards, the <span class="hlt">sisters</span> played a vital role in preparing the patients for a "good <span class="hlt">death</span>" as well as spiritual wellness. By waging their own war on the Protestant influences, the <span class="hlt">sisters</span> did their best to build their own sacred place in caring for sick bodies and saving souls. Through the research on the <span class="hlt">Sisters</span> of Charity at Charity Hospital, this study ultimately sheds light on the ways in which a nineteenth-century southern hospital functioned as a unique environment for the recovery of wellness of the body and soul, shaped and envisioned by the Catholic <span class="hlt">sister</span>-nurses' gender and religious identities.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27120695','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27120695"><span>Separase Is Required for Homolog and <span class="hlt">Sister</span> Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of <span class="hlt">Sister</span> Centromeres.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Blattner, Ariane C; Chaurasia, Soumya; McKee, Bruce D; Lehner, Christian F</p> <p>2016-04-01</p> <p>Spatially controlled release of <span class="hlt">sister</span> chromatid cohesion during progression through the meiotic divisions is of paramount importance for error-free chromosome segregation during meiosis. Cohesion is mediated by the cohesin protein complex and cleavage of one of its subunits by the endoprotease separase removes cohesin first from chromosome arms during exit from meiosis I and later from the pericentromeric region during exit from meiosis II. At the onset of the meiotic divisions, cohesin has also been proposed to be present within the centromeric region for the unification of <span class="hlt">sister</span> centromeres into a single functional entity, allowing bipolar orientation of paired homologs within the meiosis I spindle. Separase-mediated removal of centromeric cohesin during exit from meiosis I might explain <span class="hlt">sister</span> centromere individualization which is essential for subsequent biorientation of <span class="hlt">sister</span> centromeres during meiosis II. To characterize a potential involvement of separase in <span class="hlt">sister</span> centromere individualization before meiosis II, we have studied meiosis in Drosophila melanogaster males where homologs are not paired in the canonical manner. Meiosis does not include meiotic recombination and synaptonemal complex formation in these males. Instead, an alternative homolog conjunction system keeps homologous chromosomes in pairs. Using independent strategies for spermatocyte-specific depletion of separase complex subunits in combination with time-lapse imaging, we demonstrate that separase is required for the inactivation of this alternative conjunction at anaphase I onset. Mutations that abolish alternative homolog conjunction therefore result in random segregation of univalents during meiosis I also after separase depletion. Interestingly, these univalents become bioriented during meiosis II, suggesting that <span class="hlt">sister</span> centromere individualization before meiosis II does not require separase.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10827941','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10827941"><span>Splitting the chromosome: cutting the ties that bind <span class="hlt">sister</span> chromatids.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nasmyth, K; Peters, J M; Uhlmann, F</p> <p>2000-05-26</p> <p>In eukaryotic cells, <span class="hlt">sister</span> DNA molecules remain physically connected from their production at S phase until their separation during anaphase. This cohesion is essential for the separation of <span class="hlt">sister</span> chromatids to opposite poles of the cell at mitosis. It also permits chromosome segregation to take place long after duplication has been completed. Recent work has identified a multisubunit complex called cohesin that is essential for connecting <span class="hlt">sisters</span>. Proteolytic cleavage of one of cohesin's subunits may trigger <span class="hlt">sister</span> separation at the onset of anaphase.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15530774','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15530774"><span>Coordination of cell <span class="hlt">death</span> and the cell cycle: <span class="hlt">linking</span> proliferation to <span class="hlt">death</span> through private and communal couplers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Abrams, John M; White, Michael A</p> <p>2004-12-01</p> <p>In development and in the adult, complex signaling pathways operate within and between cells to coordinate proliferation and cell <span class="hlt">death</span>. These networks can be viewed as coupling devices that <span class="hlt">link</span> engines driving the cell cycle and the initiation of apoptosis. We propose three simple frameworks for modeling the effects of proliferative drive on apoptotic propensity. This perspective offers a potentially useful foundation for predicting group behaviors of cells in normal and pathological settings.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29079493','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29079493"><span>Is adenosine associated with sudden <span class="hlt">death</span> in schizophrenia? A new framework <span class="hlt">linking</span> the adenosine pathway to risk of sudden <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gadelha, Ary; Zugman, André; Calzavara, Mariana Bendlin; de Mendonça Furtado, Remo Holanda; Scorza, Fulvio Alexandre; Bressan, Rodrigo Afonsecca</p> <p>2018-01-01</p> <p>Schizophrenia is associated with an increased mortality from cardiovascular disease. Relatively few studies have assessed the putative association of schizophrenia pathophysiology with sudden <span class="hlt">death</span>. Low adenosine levels have been associated with schizophrenia. In cardiology, increased mortality among patients with congestive heart failure has been associated with genetic polymorphisms that potentially lead to lower adenosine levels. Thus, we hypothesize that adenosine could <span class="hlt">link</span> schizophrenia and cardiovascular mortality, with decreased adenosine levels leading to increased vulnerability to hyperexcitability following hypoxic insults, increasing the odds of fatal arrhythmias. Low adenosine levels might also lead to a small increase in overall mortality rates and a major increase in the sudden <span class="hlt">death</span> rate. This hypothesis paves the way for further investigation of the increased cardiac mortality associated with schizophrenia. Potentially, a better characterization of adenosine-related mechanisms of sudden <span class="hlt">death</span> in schizophrenia could lead to new evidence of factors leading to sudden <span class="hlt">death</span> in the general population. Copyright © 2017. Published by Elsevier Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4847790','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4847790"><span>Separase Is Required for Homolog and <span class="hlt">Sister</span> Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of <span class="hlt">Sister</span> Centromeres</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Blattner, Ariane C.; McKee, Bruce D.; Lehner, Christian F.</p> <p>2016-01-01</p> <p>Spatially controlled release of <span class="hlt">sister</span> chromatid cohesion during progression through the meiotic divisions is of paramount importance for error-free chromosome segregation during meiosis. Cohesion is mediated by the cohesin protein complex and cleavage of one of its subunits by the endoprotease separase removes cohesin first from chromosome arms during exit from meiosis I and later from the pericentromeric region during exit from meiosis II. At the onset of the meiotic divisions, cohesin has also been proposed to be present within the centromeric region for the unification of <span class="hlt">sister</span> centromeres into a single functional entity, allowing bipolar orientation of paired homologs within the meiosis I spindle. Separase-mediated removal of centromeric cohesin during exit from meiosis I might explain <span class="hlt">sister</span> centromere individualization which is essential for subsequent biorientation of <span class="hlt">sister</span> centromeres during meiosis II. To characterize a potential involvement of separase in <span class="hlt">sister</span> centromere individualization before meiosis II, we have studied meiosis in Drosophila melanogaster males where homologs are not paired in the canonical manner. Meiosis does not include meiotic recombination and synaptonemal complex formation in these males. Instead, an alternative homolog conjunction system keeps homologous chromosomes in pairs. Using independent strategies for spermatocyte-specific depletion of separase complex subunits in combination with time-lapse imaging, we demonstrate that separase is required for the inactivation of this alternative conjunction at anaphase I onset. Mutations that abolish alternative homolog conjunction therefore result in random segregation of univalents during meiosis I also after separase depletion. Interestingly, these univalents become bioriented during meiosis II, suggesting that <span class="hlt">sister</span> centromere individualization before meiosis II does not require separase. PMID:27120695</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_1");'>1</a></li> <li class="active"><span>2</span></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_2 --> <div id="page_3" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_1");'>1</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li class="active"><span>3</span></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="41"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27618205','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27618205"><span>little <span class="hlt">sister</span>: An Afro-Temporal Solo-Play.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>De Berry, Misty</p> <p>2017-07-03</p> <p>little <span class="hlt">sister</span>: An Afro-Temporal Solo-Play is at once a memory-scape and a mytho-biography set to poetry, movement, and mixed media. A performance poem spanning from the Antebellum South to present-moment Chicago, it tells the story of a nomadic spirit named little-she who shape-shifts through the memories and imaginings of her <span class="hlt">sister</span>, the narrator. Through the characters little-she and the narrator, the solo-performance explores embodied ways to rupture and relieve the impact of macro forms of violence in the micro realm of the everyday. To this end, little <span class="hlt">sister</span> witnesses and disrupts the legacy of violence in the lives of queer Black women through a trans-temporal navigation of everyday encounters within familial, small groups and intimate partner spaces.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3674063','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3674063"><span><span class="hlt">Sister</span> chromatid segregation in meiosis II</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wassmann, Katja</p> <p>2013-01-01</p> <p>Meiotic divisions (meiosis I and II) are specialized cell divisions to generate haploid gametes. The first meiotic division with the separation of chromosomes is named reductional division. The second division, which takes place immediately after meiosis I without intervening S-phase, is equational, with the separation of <span class="hlt">sister</span> chromatids, similar to mitosis. This meiotic segregation pattern requires the two-step removal of the cohesin complex holding <span class="hlt">sister</span> chromatids together: cohesin is removed from chromosome arms that have been subjected to homologous recombination in meiosis I and from the centromere region in meiosis II. Cohesin in the centromere region is protected from removal in meiosis I, but this protection has to be removed—deprotected”—for <span class="hlt">sister</span> chromatid segregation in meiosis II. Whereas the mechanisms of cohesin protection are quite well understood, the mechanisms of deprotection have been largely unknown until recently. In this review I summarize our current knowledge on cohesin deprotection. PMID:23574717</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title46-vol7/pdf/CFR-2010-title46-vol7-sec169-307.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title46-vol7/pdf/CFR-2010-title46-vol7-sec169-307.pdf"><span>46 CFR 169.307 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 46 Shipping 7 2010-10-01 2010-10-01 false Plans for <span class="hlt">sister</span> vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for <span class="hlt">sister</span> vessels. Plans are not required for any vessel...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title46-vol7/pdf/CFR-2011-title46-vol7-sec169-307.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title46-vol7/pdf/CFR-2011-title46-vol7-sec169-307.pdf"><span>46 CFR 169.307 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 46 Shipping 7 2011-10-01 2011-10-01 false Plans for <span class="hlt">sister</span> vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for <span class="hlt">sister</span> vessels. Plans are not required for any vessel...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28845135','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28845135"><span>Adolescents' Experiences 7 and 13 Months Following the <span class="hlt">Death</span> of a Brother or <span class="hlt">Sister</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Brooten, Dorothy; Youngblut, JoAnne M; Roche, Rosa M</p> <p>2017-06-01</p> <p>This qualitative study used semi-structured interviews to describe adolescents' responses at 7 and 13 months to siblings' NICU/PICU/ED <span class="hlt">death</span>. At 7 months, adolescents were asked about events around the sibling's <span class="hlt">death</span>; at 7 and 13 months, about concerns/fears, feelings, and life changes. Seventeen adolescents participated (13-18 years; M=15); 65% Black, 24% Hispanic, 11% White. Themes included <span class="hlt">death</span> circumstances, burial events, thinking about the deceased sibling, fears, and life changes. Adolescents reported shock and disbelief that the sibling died; 80% knew the reason for the <span class="hlt">death</span>; many had difficulty getting through burials; all thought about the sibling. From 7 - 13 months fears increased including losing someone and thoughts of dying. Adolescents reported more changes in family life and greater life changes in them (more considerate, mature) by 13 months; some felt friends abandoned them after the sibling's <span class="hlt">death</span>. Girls had more fears and changes in family life and themselves. Adolescent's responses to sibling <span class="hlt">death</span> may not be visually apparent. One recommendation from this study is to ask adolescents how they are doing separately from parents since adolescents may hide feelings to protect their parents, especially their mothers. Older adolescents (14-18 years) and girls may have more difficulty after sibling <span class="hlt">death</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=sister+AND+cities&id=EJ437613','ERIC'); return false;" href="https://eric.ed.gov/?q=sister+AND+cities&id=EJ437613"><span>Building International Relations for Children through <span class="hlt">Sister</span> Schools.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Pryor, Carolyn B.</p> <p>1992-01-01</p> <p>Inspired by <span class="hlt">Sister</span> Cities International and the NASSP's school-to-school exchange program, "<span class="hlt">sister</span> school" pairings have proved to be workable educational programs with long-range impact on participants. Some post-cold war efforts include U.S.-USSR High School Academic Partnerships, Project Harmony, and Center for U.S.-USSR Initiatives.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5963586','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5963586"><span>The <span class="hlt">Sister</span> Study Cohort: Baseline Methods and Participant Characteristics</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hodgson, M. Elizabeth; Deming-Halverson, Sandra L.; Juras, Paula S.; D’Aloisio, Aimee A.; Suarez, Lourdes M.; Kleeberger, Cynthia A.; Shore, David L.; DeRoo, Lisa A.; Taylor, Jack A.; Weinberg, Clarice R.</p> <p>2017-01-01</p> <p>Background: The <span class="hlt">Sister</span> Study was designed to address gaps in the study of environment and breast cancer by taking advantage of more frequent breast cancer diagnoses among women with a <span class="hlt">sister</span> history of breast cancer and the presumed enrichment of shared environmental and genetic exposures. Objective: The <span class="hlt">Sister</span> Study sought a large cohort of women never diagnosed with breast cancer but who had a <span class="hlt">sister</span> (full or half) diagnosed with breast cancer. Methods: A multifaceted national effort employed novel strategies to recruit a diverse cohort, and collected biological and environmental samples and extensive data on potential breast cancer risk factors. Results: The <span class="hlt">Sister</span> Study enrolled 50,884 U.S. and Puerto Rican women 35–74y of age (median 56 y). Although the majority were non-Hispanic white, well educated, and economically well off, substantial numbers of harder-to-recruit women also enrolled (race/ethnicity other than non-Hispanic white: 16%; no college degree: 35%; household income <$50,000: 26%). Although all had a biologic <span class="hlt">sister</span> with breast cancer, 16.5% had average or lower risk of breast cancer according to the Breast Cancer Risk Assessment Tool (Gail score). Most were postmenopausal (66%), parous with a first full-term pregnancy <30y of age (79%), never-smokers (56%) with body mass indexes (BMIs) of <29.9 kg/m2 (70%). Few (5%) reported any cancer prior to enrollment. Conclusions: The <span class="hlt">Sister</span> Study is a unique cohort designed to efficiently study environmental and genetic risk factors for breast cancer. Extensive exposure data over the life-course and baseline specimens provide important opportunities for studying breast cancer and other health outcomes in women. Collaborations are welcome. https://doi.org/10.1289/EHP1923 PMID:29373861</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20503771','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20503771"><span>[Two Dutch <span class="hlt">sisters</span> in analysis with Freud].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stroeken, Harry</p> <p>2010-01-01</p> <p>The author provides persuasive or at least plausible data for the identity of two patients recorded by Freud in his working season of 1910/11. They were two <span class="hlt">sisters</span>, living in The Hague/Leiden, who came from a rich banker's family, the van der Lindens. Whereas the treatment does not seem to have led to any decisive improvement for the older of the two, it may have encouraged the younger <span class="hlt">sister</span> to seek divorce.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20966869','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20966869"><span>The <span class="hlt">death</span> of Florence Nightingale: BJN 100 years ago.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Castledine, Sir George</p> <p></p> <p>This August marks the centenary of the <span class="hlt">death</span> of Florence Nightingale, who died at 2 o'clock on Saturday 13 August 1910 at her home, 10 South Street, Park Lane, London. The following are some snippets which appeared in the BJN of the 20 and 27 August 1910. It was not until the announcement of her <span class="hlt">death</span> in the morning papers of Monday 15 August that the country heard about Nightingale's <span class="hlt">death</span>. In her last hours she was attended by Sir Thomas Barlow and two nurses from the Nursing <span class="hlt">Sisters</span>' Institution, Devonshire Square, founded by Mrs Elizabeth Fry in 1840.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22747900','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22747900"><span>Enhanced reporting of <span class="hlt">deaths</span> among Aboriginal and Torres Strait Islander peoples using <span class="hlt">linked</span> administrative health datasets.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Taylor, Lee K; Bentley, Jason; Hunt, Jennifer; Madden, Richard; McKeown, Sybille; Brandt, Peter; Baker, Deborah</p> <p>2012-07-02</p> <p>Aboriginal and Torres Strait Islander peoples are under-reported in administrative health datasets in NSW, Australia. Correct reporting of Aboriginal and Torres Strait Islander peoples is essential to measure the effectiveness of policies and programmes aimed at reducing the health disadvantage experienced by Aboriginal and Torres Strait Islander peoples. This study investigates the potential of record linkage to enhance reporting of <span class="hlt">deaths</span> among Aboriginal and Torres Strait Islander peoples in NSW, Australia. Australian Bureau of Statistics <span class="hlt">death</span> registration data for 2007 were <span class="hlt">linked</span> with four population health datasets relating to hospitalisations, emergency department attendances and births. Reporting of <span class="hlt">deaths</span> was enhanced from <span class="hlt">linked</span> records using two methods, and effects on patterns of demographic characteristics and mortality indicators were examined. Reporting of <span class="hlt">deaths</span> increased by 34.5% using an algorithm based on a weight of evidence of a person being Aboriginal or Torres Strait Islander, and by 56.6% using an approach based on 'at least one report' of a person being Aboriginal or Torres Strait Islander. The increase was relatively greater in older persons and those living in less geographically remote areas. Enhancement resulted in a reduction in the urban-remote differential in median age at <span class="hlt">death</span> and increases in standardised mortality ratios particularly for chronic conditions. Record linkage creates a statistical construct that helps to correct under-reporting of <span class="hlt">deaths</span> and potential bias in mortality statistics for Aboriginal and Torres Strait Islander peoples.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1995Mercu..24e..23B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1995Mercu..24e..23B"><span>The Prodigal <span class="hlt">Sister</span> - Venus</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Barlow, Nadine G.</p> <p>1995-09-01</p> <p>If you think Venus is a hellhole now, be thankful you weren't there 500 million years ago. Those were the days, many planetary scientists believe, of apocalypse on our <span class="hlt">sister</span> world: Volcanoes wracked the land, while greenhouse gases broiled the air. Is this the Earth's fate, too?</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1205336','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1205336"><span>Replication-Dependent <span class="hlt">Sister</span> Chromatid Recombination in Rad1 Mutants of Saccharomyces Cerevisiae</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kadyk, L. C.; Hartwell, L. H.</p> <p>1993-01-01</p> <p>Homolog recombination and unequal <span class="hlt">sister</span> chromatid recombination were monitored in rad1-1/rad1-1 diploid yeast cells deficient for excision repair, and in control cells, RAD1/rad1-1, after exposure to UV irradiation. In a rad1-1/rad1-1 diploid, UV irradiation stimulated much more <span class="hlt">sister</span> chromatid recombination relative to homolog recombination when cells were irradiated in the G(1) or the G(2) phases of the cell cycle than was observed in RAD1/rad1-1 cells. Since <span class="hlt">sister</span> chromatids are not present during G(1), this result suggested that unexcised lesions can stimulate <span class="hlt">sister</span> chromatid recombination events during or subsequent to DNA replication. The results of mating rescue experiments suggest that unexcised UV dimers do not stimulate <span class="hlt">sister</span> chromatid recombination during the G(2) phase, but only when they are present during DNA replication. We propose that there are two types of <span class="hlt">sister</span> chromatid recombination in yeast. In the first type, unexcised UV dimers and other bulky lesions induce <span class="hlt">sister</span> chromatid recombination during DNA replication as a mechanism to bypass lesions obstructing the passage of DNA polymerase, and this type is analogous to the type of <span class="hlt">sister</span> chromatid exchange commonly observed cytologically in mammalian cells. In the second type, strand scissions created by X-irradiation or the excision of damaged bases create recombinogenic sites that result in <span class="hlt">sister</span> chromatid recombination directly in G(2). Further support for the existence of two types of <span class="hlt">sister</span> chromatid recombination is the fact that events induced in rad1-1/rad1-1 were due almost entirely to gene conversion, whereas those in RAD1/rad1-1 cells were due to a mixture of gene conversion and reciprocal recombination. PMID:8454200</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3338871','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3338871"><span>Changes in Siblings after the <span class="hlt">Death</span> of a Child from Cancer</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Foster, Terrah L.; Gilmer, Mary Jo; Vannatta, Kathryn; Barrera, Maru; Davies, Betty; Dietrich, Mary S.; Fairclough, Diane L.; Gerhardt, Cynthia A.</p> <p>2011-01-01</p> <p>Background Few studies have examined changes in siblings after the <span class="hlt">death</span> of a brother or <span class="hlt">sister</span>, particularly from mother, father, and sibling perspectives within the first year post-<span class="hlt">death</span>. Objective This descriptive study identified and assessed the frequency of changes in siblings after a child's <span class="hlt">death</span> from cancer. Methods Participants were recruited from cancer registries at three hospitals in the U.S. and Canada 3–12 months after the child's <span class="hlt">death</span>. Thirty-six mothers, 24 fathers, and 39 siblings from 40 families were included. Semi-structured interviews using open-ended questions were conducted with each parent and sibling separately in the home. Content analysis identified emerging themes, and McNemar tests compared frequencies between each paired set of reports (sibling vs. mother, sibling vs. father, mother vs. father). Results Sixty-nine percent of participants reported personal changes in siblings (e.g., changes in personality, school work, goals/life perspective, activities/interests). Forty-seven percent noted changes in siblings' relationships with family members and peers. Only 21% of participants reported no changes attributed to the <span class="hlt">death</span>. Comparisons of frequencies across informants were not significant. Conclusions Most siblings experienced changes in multiple areas of their lives after the <span class="hlt">death</span> of a brother or <span class="hlt">sister</span> to cancer. Some changes reflected siblings that were positively adapting to the <span class="hlt">death</span>, while other changes reflected difficulties. Implications for practice Our findings offer guidance to improve aftercare for bereaved siblings and their families. Additional research is needed to further delineate the needs of bereaved siblings and to develop strategies to promote adaptation to loss. PMID:22067687</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22067687','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22067687"><span>Changes in siblings after the <span class="hlt">death</span> of a child from cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Foster, Terrah L; Gilmer, Mary Jo; Vannatta, Kathryn; Barrera, Maru; Davies, Betty; Dietrich, Mary S; Fairclough, Diane L; Gerhardt, Cynthia A</p> <p>2012-01-01</p> <p>Few studies have examined changes in siblings after the <span class="hlt">death</span> of a brother or <span class="hlt">sister</span>, particularly from mother, father, and sibling perspectives within the first year after <span class="hlt">death</span>. This descriptive study identified and assessed the frequency of changes in siblings after a child's <span class="hlt">death</span> from cancer. Participants were recruited from cancer registries at 3 hospitals in the United States and Canada 3 to 12 months after the child's <span class="hlt">death</span>. Thirty-six mothers, 24 fathers, and 39 siblings from 40 families were included. Semistructured interviews using open-ended questions were conducted with each parent and sibling separately in the home. Content analysis identified emerging themes, and the McNemar tests compared frequencies between each paired set of reports (sibling vs mother, sibling vs father, mother vs father). Sixty-nine percent of participants reported personal changes in siblings (eg, changes in personality, school work, goals/life perspective, activities/interests). Forty-seven percent noted changes in siblings' relationships with family members and peers. Only 21% of participants reported no changes attributed to the <span class="hlt">death</span>. Comparisons of frequencies across informants were not significant. Most siblings experienced changes in multiple areas of their lives after the <span class="hlt">death</span> of a brother or <span class="hlt">sister</span> to cancer. Some changes reflected siblings that were positively adapting to the <span class="hlt">death</span>, whereas other changes reflected difficulties. Our findings offer guidance to improve aftercare for bereaved siblings and their families. Additional research is needed to further delineate the needs of bereaved siblings and to develop strategies to promote adaptation to loss.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21910232','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21910232"><span>Two <span class="hlt">sisters</span> resembling Gorlin-Chaudhry-Moss syndrome.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Aravena, Teresa; Passalacqua, Cristóbal; Pizarro, Oscar; Aracena, Mariana</p> <p>2011-10-01</p> <p>The Gorlin-Chaudhry-Moss syndrome (GCMS), was describe initially by Gorlin et al. [Gorlin et al. (1960)] in two <span class="hlt">sisters</span> with craniosynostosis, hypertrichosis, hypoplastic labia majora, dental defects, eye anomalies, patent ductus arteriosus, and normal intelligence. Two other sporadic instances have been documented. Here, we report on two <span class="hlt">sisters</span> with a condition with some similarities to GCMS as well as some differences, which could represent either previously unreported variability in GCMS, or it may represent a novel disorder. Copyright © 2011 Wiley-Liss, Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25213378','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25213378"><span><span class="hlt">Sister</span> kinetochores are mechanically fused during meiosis I in yeast.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sarangapani, Krishna K; Duro, Eris; Deng, Yi; Alves, Flavia de Lima; Ye, Qiaozhen; Opoku, Kwaku N; Ceto, Steven; Rappsilber, Juri; Corbett, Kevin D; Biggins, Sue; Marston, Adèle L; Asbury, Charles L</p> <p>2014-10-10</p> <p>Production of healthy gametes requires a reductional meiosis I division in which replicated <span class="hlt">sister</span> chromatids comigrate, rather than separate as in mitosis or meiosis II. Fusion of <span class="hlt">sister</span> kinetochores during meiosis I may underlie <span class="hlt">sister</span> chromatid comigration in diverse organisms, but direct evidence for such fusion has been lacking. We used laser trapping and quantitative fluorescence microscopy to study native kinetochore particles isolated from yeast. Meiosis I kinetochores formed stronger attachments and carried more microtubule-binding elements than kinetochores isolated from cells in mitosis or meiosis II. The meiosis I-specific monopolin complex was both necessary and sufficient to drive these modifications. Thus, kinetochore fusion directs <span class="hlt">sister</span> chromatid comigration, a conserved feature of meiosis that is fundamental to Mendelian inheritance. Copyright © 2014, American Association for the Advancement of Science.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ1006063.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ1006063.pdf"><span><span class="hlt">Sister</span> Mary Emil Penet, I.H.M.: Founder of the <span class="hlt">Sister</span> Formation Conference</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Glisky, Joan</p> <p>2006-01-01</p> <p>Mary Emil Penet, I.H.M., (1916-2001) used her talents and charisma to shape the first national organization of American women religious, the <span class="hlt">Sister</span> Formation Conference (SFC; 1954-1964), facilitating the integrated intellectual, spiritual, psychological, and professional development of vowed women religious. In the decade preceding Vatican II, her…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1509088','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1509088"><span>Hyaline membrane disease is underreported in a <span class="hlt">linked</span> birth-infant <span class="hlt">death</span> certificate database.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hamvas, A; Kwong, P; DeBaun, M; Schramm, W; Cole, F S</p> <p>1998-01-01</p> <p>OBJECTIVE: This study compared the Missouri State Department of Health <span class="hlt">linked</span> birth-infant <span class="hlt">death</span> certificate database and medical records with respect to recording hyaline membrane disease in very low-birth-weight infants. METHODS: We reviewed the records for all 976 infants weighing 500 to 1500 g who were born to St. Louis, Mo, residents in 1989, 1991, and 1992. RESULTS: Eighteen percent of the birth certificates and 54% of the medical records documented hyaline membrane disease, resulting in 34% sensitivity and 99% specificity. CONCLUSIONS: The Missouri State Department of Health birth-infant <span class="hlt">death</span> certificate database underestimates the incidence of hyaline membrane disease, which suggest that national statistics for the disease are also underestimated. PMID:9736884</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.usgs.gov/of/2007/1221/','USGSPUBS'); return false;" href="https://pubs.usgs.gov/of/2007/1221/"><span>Digital Data for Volcano Hazards of the Three <span class="hlt">Sisters</span> Region, Oregon</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Schilling, S.P.; Doelger, S.; Scott, W.E.; Iverson, R.M.</p> <p>2008-01-01</p> <p>Three <span class="hlt">Sisters</span> is one of three active volcanic centers that lie close to rapidly growing communities and resort areas in Central Oregon. The major composite volcanoes of this area are clustered near the center of the region and include South <span class="hlt">Sister</span>, Middle <span class="hlt">Sister</span>, and Broken Top. Additionally, hundreds of mafic volcanoes are scattered throughout the Three <span class="hlt">Sisters</span> area. These range from small cinder cones to large shield volcanoes like North <span class="hlt">Sister</span> and Belknap Crater. Hazardous events include landslides from the steep flanks of large volcanoes and floods, which need not be triggered by eruptions, as well as eruption-triggered events such as fallout of tephra (volcanic ash) and lava flows. A proximal hazard zone roughly 20 kilometers (12 miles) in diameter surrounding the Three <span class="hlt">Sisters</span> and Broken Top could be affected within minutes of the onset of an eruption or large landslide. Distal hazard zones that follow river valleys downstream from the Three <span class="hlt">Sisters</span> and Broken Top could be inundated by lahars (rapid flows of water-laden rock and mud) generated either by melting of snow and ice during eruptions or by large landslides. Slow-moving lava flows could issue from new mafic volcanoes almost anywhere within the region. Fallout of tephra from eruption clouds can affect areas hundreds of kilometers (miles) downwind, so eruptions at volcanoes elsewhere in the Cascade Range also contribute to volcano hazards in Central Oregon. Scientists at the Cascades Volcano Observatory created a geographic information system (GIS) data set which depicts proximal and distal lahar hazard zones as well as a regional lava flow hazard zone for Three <span class="hlt">Sisters</span> (USGS Open-File Report 99-437, Scott and others, 1999). The various distal lahar zones were constructed from LaharZ software using 20, 100, and 500 million cubic meter input flow volumes. Additionally, scientists used the depositional history of past events in the Three <span class="hlt">Sisters</span> Region as well as experience and judgment derived from the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/478890-neuropsychological-profiles-three-sisters-homozygous-fragile-premutation','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/478890-neuropsychological-profiles-three-sisters-homozygous-fragile-premutation"><span>Neuropsychological profiles of three <span class="hlt">sisters</span> homozygous for the fragile X premutation</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Mazzocco, M.M.M.; Holden, J.J.A.</p> <p>1996-08-09</p> <p>Fragile X syndrome (fraX) is associated with an amplification of a CGG repeat within the fraX mental retardation (FMR-1) gene. We describe an exceptional family in which 3 adult <span class="hlt">sisters</span> are homozygous for the FMR-1 premutation. Each <span class="hlt">sister</span> inherited 2 premutation alleles (ca. 80 CGG repeats) from their biologically unrelated parents. The 3 <span class="hlt">sisters</span> were administered measures of executive function, visual spatial, memory, and verbal skills. Deficiencies in the first 2 of these domains have been reported among females with the full mutation. The <span class="hlt">sisters</span>` performances were compared with available normative data and with published group means for females affectedmore » by fraX. These women did not appear to have verbal or memory difficulties. None of the women demonstrated a global executive function deficit, and none had global deficits in spatial ability. The profiles of these <span class="hlt">sisters</span> are consistent with reports that the fragile X premutation does not affect cognitive performance. 31 refs., 1 fig., 4 tabs.« less</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_1");'>1</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li class="active"><span>3</span></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_3 --> <div id="page_4" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li class="active"><span>4</span></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="61"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3348944','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3348944"><span>Having a Brother or <span class="hlt">Sister</span> with Down Syndrome: Perspectives from Siblings</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Skotko, Brian G.; Levine, Susan P.; Goldstein, Richard</p> <p>2012-01-01</p> <p>This study asks brothers and <span class="hlt">sisters</span> about their feelings and perceptions toward their sibling with Down syndrome. We analyzed valid and reliable surveys from 822 brothers and <span class="hlt">sisters</span> whose families were on the mailing lists of six non-profit Down syndrome organizations around the country. More than 96% of brothers/<span class="hlt">sisters</span> that responded to the survey indicated that they had affection toward their sibling with Down syndrome; and 94% of older siblings expressed feelings of pride. Less than 10% felt embarrassed, and less than 5% expressed a desire to trade their sibling in for another brother or <span class="hlt">sister</span> without Down syndrome. Among older siblings, 88% felt that they were better people because of their siblings with Down syndrome, and more than 90% plan to remain involved in their sibling’s lives as they become adults. The vast majority of brothers and <span class="hlt">sisters</span> describe their relationship with their sibling with Down syndrome as positive and enriching. PMID:21910244</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11444040','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11444040"><span>Splitting the chromosome: cutting the ties that bind <span class="hlt">sister</span> chromatids.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nasmyth, K; Peters, J M; Uhlmann, F</p> <p>2001-01-01</p> <p>In eukaryotic cells, replicated DNA molecules remain physically connected from their synthesis in S phase until they are separated during anaphase. This phenomenon, called <span class="hlt">sister</span> chromatid cohesion, is essential for the temporal separation of DNA replication and mitosis and for the equal separation of the duplicated genome. Recent work has identified a number of chromosomal proteins required for cohesion. In this review we discuss how these proteins may connect <span class="hlt">sister</span> chromatids and how they are removed from chromosomes to allow <span class="hlt">sister</span> chromatid separation at the onset of anaphase.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26485307','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26485307"><span><span class="hlt">Linking</span> mortuary data improves vital statistics on cause of <span class="hlt">death</span> of children under five years in the Western Cape Province of South Africa.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Groenewald, Pam; Bradshaw, Debbie; Neethling, Ian; Martin, Lorna J; Dempers, Johan; Morden, Erna; Zinyakatira, Nesbert; Coetzee, David</p> <p>2016-01-01</p> <p>Reducing child mortality requires good information on its causes. Whilst South African vital registration data have improved, the quality of cause-of-<span class="hlt">death</span> data remains inadequate. To improve this, data from <span class="hlt">death</span> certificates were <span class="hlt">linked</span> with information from forensic mortuaries in Western Cape Province. A local mortality surveillance system was established in 2007 by the Western Cape Health Department to improve data quality. Cause-of-<span class="hlt">death</span> data were captured from copies of <span class="hlt">death</span> notification forms collected at Department of Home Affairs Offices. Using unique identifiers, additional forensic mortuary data were <span class="hlt">linked</span> with mortality surveillance system records. Causes of <span class="hlt">death</span> were coded to the ICD-10 classification. Causes of <span class="hlt">death</span> in children under five were compared with those from vital registration data for 2011. Cause-of-<span class="hlt">death</span> data were markedly improved with additional data from forensic mortuaries. The proportion of ill-defined causes was halved (25-12%), and leading cause rankings changed. Lower respiratory tract infections moved above prematurity to rank first, accounting for 20.8% of <span class="hlt">deaths</span> and peaking in infants aged 1-3 months. Only 11% of <span class="hlt">deaths</span> from lower respiratory tract infections occurred in hospital, resulting in 86% being certified in forensic mortuaries. Road traffic <span class="hlt">deaths</span> increased from 1.1-3.1% (27-75) and homicides from 3 to 28. The quality and usefulness of cause-of-<span class="hlt">death</span> information for children in the WC was enhanced by <span class="hlt">linking</span> mortuary and vital registration data. Given the <span class="hlt">death</span> profile, interventions are required to prevent and manage LRTI, diarrhoea and injuries and to reduce neonatal <span class="hlt">deaths</span>. © 2015 John Wiley & Sons Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4889787','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4889787"><span>GNE Myopathy in Turkish <span class="hlt">Sisters</span> with a Novel Homozygous Mutation</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Diniz, Gulden; Secil, Yaprak; Ceylaner, Serdar; Tokucoglu, Figen; Türe, Sabiha; Celebisoy, Mehmet; İncesu, Tülay Kurt; Akhan, Galip</p> <p>2016-01-01</p> <p>Background. Hereditary inclusion body myopathy is caused by biallelic defects in the GNE gene located on chromosome 9p13. It generally affects adults older than 20 years of age. Methods and Results. In this study, we present two Turkish <span class="hlt">sisters</span> with progressive myopathy and describe a novel mutation in the GNE gene. Both <span class="hlt">sisters</span> had slightly higher levels of creatine kinase (CK) and muscle weakness. The older <span class="hlt">sister</span> presented at 38 years of age with an inability to climb steps, weakness, and a steppage gait. Her younger <span class="hlt">sister</span> was 36 years old and had similar symptoms. The first symptoms of the disorder were seen when the <span class="hlt">sisters</span> were 30 and 34 years old, respectively. The muscle biopsy showed primary myopathic features and presence of rimmed vacuoles. DNA analysis demonstrated the presence of previously unknown homozygous mutations [c.2152 G>A (p.A718T)] in the GNE genes. Conclusion. Based on our literature survey, we believe that ours is the first confirmed case of primary GNE myopathy with a novel missense mutation in Turkey. These patients illustrate that the muscle biopsy is still an important method for the differential diagnosis of vacuolar myopathies in that the detection of inclusions is required for the definitive diagnosis. PMID:27298745</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21695086','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21695086"><span>Embryonic <span class="hlt">death</span> is <span class="hlt">linked</span> to maternal identity in the leatherback turtle (Dermochelys coriacea).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rafferty, Anthony R; Santidrián Tomillo, Pilar; Spotila, James R; Paladino, Frank V; Reina, Richard D</p> <p>2011-01-01</p> <p>Leatherback turtles have an average global hatching success rate of ~50%, lower than other marine turtle species. Embryonic <span class="hlt">death</span> has been <span class="hlt">linked</span> to environmental factors such as precipitation and temperature, although, there is still a lot of variability that remains to be explained. We examined how nesting season, the time of nesting each season, the relative position of each clutch laid by each female each season, maternal identity and associated factors such as reproductive experience of the female (new nester versus remigrant) and period of egg retention between clutches (interclutch interval) affected hatching success and stage of embryonic <span class="hlt">death</span> in failed eggs of leatherback turtles nesting at Playa Grande, Costa Rica. Data were collected during five nesting seasons from 2004/05 to 2008/09. Mean hatching success was 50.4%. Nesting season significantly influenced hatching success in addition to early and late stage embryonic <span class="hlt">death</span>. Neither clutch position nor nesting time during the season had a significant affect on hatching success or the stage of embryonic <span class="hlt">death</span>. Some leatherback females consistently produced nests with higher hatching success rates than others. Remigrant females arrived earlier to nest, produced more clutches and had higher rates of hatching success than new nesters. Reproductive experience did not affect stage of <span class="hlt">death</span> or the duration of the interclutch interval. The length of interclutch interval had a significant affect on the proportion of eggs that failed in each clutch and the developmental stage they died at. Intrinsic factors such as maternal identity are playing a role in affecting embryonic <span class="hlt">death</span> in the leatherback turtle.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12808731','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12808731"><span>Paternity testing in case of brother-<span class="hlt">sister</span> incest.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Macan, Marijana; Uvodić, Petra; Botica, Vladimir</p> <p>2003-06-01</p> <p>We performed a paternity test in a case of incest between brother and <span class="hlt">sister</span>. DNA from blood samples of the alleged parents and their two children was obtained with Chelex DNA extraction method and quantified with Applied Biosystems QuantiBlot quantitation kit. Polymerase chain reaction (PCR) amplification of DNA samples was performed with AmpFlSTR SGM Plus PCR amplification kit and GenePrint PowerPlex PCR amplification kit. The amplified products were separated and detected by using the Perkin Elmer's ABI PRISM trade mark 310 Genetic Analyser. DNA and data analysis of 17 loci and Amelogenin confirmed the suspicion of brother-<span class="hlt">sister</span> incest. Since both children had inherited all of the obligate alleles from the alleged father, we could confirm with certainty of 99.999999% that the oldest brother in the family was the biological father of both children. Calculated data showed that even in a case of brother-<span class="hlt">sister</span> incest, paternity could be proved by the analysis of Amelogenin and 17 DNA loci.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.usgs.gov/sim/3186/data/pdf/sim3186_pamphlet.pdf','USGSPUBS'); return false;" href="https://pubs.usgs.gov/sim/3186/data/pdf/sim3186_pamphlet.pdf"><span>Geologic map of Three <span class="hlt">Sisters</span> volcanic cluster, Cascade Range, Oregon</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Hildreth, Wes; Fierstein, Judy; Calvert, Andrew T.</p> <p>2012-01-01</p> <p>The cluster of glaciated stratovolcanoes called the Three Sisters—South <span class="hlt">Sister</span>, Middle <span class="hlt">Sister</span>, and North Sister—forms a spectacular 20-km-long reach along the crest of the Cascade Range in Oregon. The three eponymous stratocones, though contiguous and conventionally lumped sororally, could hardly display less family resemblance. North <span class="hlt">Sister</span> (10,085 ft), a monotonously mafic edifice at least as old as 120 ka, is a glacially ravaged stratocone that consists of hundreds of thin rubbly lava flows and intercalated falls that dip radially and steeply; remnants of two thick lava flows cap its summit. Middle <span class="hlt">Sister</span> (10,047 ft), an andesite-basalt-dacite cone built between 48 and 14 ka, is capped by a thick stack of radially dipping, dark-gray, thin mafic lava flows; asymmetrically glaciated, its nearly intact west flank contrasts sharply with its steep east face. Snow and ice-filled South <span class="hlt">Sister</span> is a bimodal rhyolitic-intermediate edifice that was constructed between 50 ka and 2 ka; its crater (rim at 10,358 ft) was created between 30 and 22 ka, during the most recent of several explosive summit eruptions; the thin oxidized agglutinate that mantles its current crater rim protects a 150-m-thick pyroclastic sequence that helped fill a much larger crater. For each of the three, the eruptive volume is likely to have been in the range of 15 to 25 km³, but such estimates are fairly uncertain, owing to glacial erosion. The map area consists exclusively of Quaternary volcanic rocks and derivative surficial deposits. Although most of the area has been modified by glaciation, the volcanoes are young enough that the landforms remain largely constructional. Furthermore, twelve of the 145 eruptive units on the map are postglacial, younger than the deglaciation that was underway by about 17 ka. The most recent eruptions were of rhyolite near South <span class="hlt">Sister</span>, about 2,000 years ago, and of mafic magma near McKenzie Pass, about 1,500 years ago. As observed by trailblazing volcanologist</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3212099','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3212099"><span><span class="hlt">Sister</span> Circles as a Culturally Relevant Intervention for Anxious African American Women</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Neal-Barnett, Angela; Stadulis, Robert; Murray, Marsheena; Payne, Margaret Ralston; Thomas, Anisha; Salley, Bernadette B.</p> <p>2011-01-01</p> <p>Research on anxiety treatment with African American women reveals a need to develop interventions that address factors relevant to their lives. Such factors include feelings of isolation, multiple roles undertaken by Black women, and faith. A recurrent theme across treatment studies is the importance of having support from other Black women. <span class="hlt">Sister</span> circles are support groups that build upon existing friendships, fictive kin networks, and the sense of community found among African Americans females. <span class="hlt">Sister</span> circles appear to offer many of the components Black women desire in an anxiety intervention. In this article, we explore <span class="hlt">sister</span> circles as an intervention for anxious African American women. Culturally-infused aspects from our <span class="hlt">sister</span> circle work with middle-class African American women are presented. Further research is needed. PMID:22081747</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16766093','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16766093"><span>Women in-between' (Strathern, 1995): the ambiguous position of the <span class="hlt">sister</span> tutor, 1918-1960.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Brooks, Jane</p> <p>2007-02-01</p> <p>The purpose of this article is to explore the ambiguous position of <span class="hlt">sister</span> tutors, within the nursing and hospital hierarchy between 1918 and 1960. The function of the <span class="hlt">sister</span> tutor was to train the probationers (student nurses). However, I will argue that the students' education was to come second to the service needs of the hospital, the authority of the matron and desire of the medical profession to maintain control over the nursing curriculum and nursing practice. Therefore <span class="hlt">sister</span> tutors were caught 'in-between' several opposing forces which together militated against the individual <span class="hlt">sister</span> tutor's work and the ability of the nursing profession to recruit adequate numbers of senior nurses into the classroom. The recruitment issue was further hampered by the widespread knowledge that much of the <span class="hlt">sister</span> tutor's work was not student education at all, but organising lectures by medical staff and marking students' notes. In order to gauge the 'official' attitudes to the <span class="hlt">sister</span> tutors and also the experiences of those who either worked as <span class="hlt">sister</span> tutors or were taught by them, I used both archival and oral evidence in the research for this article. Pseudonyms have been used throughout for the oral history respondents.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-225.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-225.pdf"><span>20 CFR 725.225 - Determination of dependency; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; parent, brother, or <span class="hlt">sister</span>. 725.225 Section 725.225 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION... Benefits) § 725.225 Determination of dependency; parent, brother, or <span class="hlt">sister</span>. An individual who is the miner...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://images.nasa.gov/#/details-PIA09263.html','SCIGOVIMAGE-NASA'); return false;" href="https://images.nasa.gov/#/details-PIA09263.html"><span>The Seven <span class="hlt">Sisters</span> Pose for Spitzer</span></a></p> <p><a target="_blank" href="https://images.nasa.gov/">NASA Image and Video Library</a></p> <p></p> <p>2007-04-16</p> <p>The Seven <span class="hlt">Sisters</span>, also known as the Pleiades star cluster, seem to float on a bed of feathers in a new infrared image from NASA Spitzer Space Telescope. Clouds of dust sweep around the stars, swaddling them in a cushiony veil.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title20-vol4/pdf/CFR-2012-title20-vol4-sec725-225.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title20-vol4/pdf/CFR-2012-title20-vol4-sec725-225.pdf"><span>20 CFR 725.225 - Determination of dependency; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-04-01</p> <p>... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of dependency; parent, brother, or <span class="hlt">sister</span>. 725.225 Section 725.225 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.225 Determination of dependency; parent, brother, or <span class="hlt">sister</span>. An individual who is the miner...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title20-vol4/pdf/CFR-2013-title20-vol4-sec725-225.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title20-vol4/pdf/CFR-2013-title20-vol4-sec725-225.pdf"><span>20 CFR 725.225 - Determination of dependency; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-04-01</p> <p>... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of dependency; parent, brother, or <span class="hlt">sister</span>. 725.225 Section 725.225 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.225 Determination of dependency; parent, brother, or <span class="hlt">sister</span>. An individual who is the miner...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title20-vol4/pdf/CFR-2014-title20-vol4-sec725-225.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title20-vol4/pdf/CFR-2014-title20-vol4-sec725-225.pdf"><span>20 CFR 725.225 - Determination of dependency; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-04-01</p> <p>... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of dependency; parent, brother, or <span class="hlt">sister</span>. 725.225 Section 725.225 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.225 Determination of dependency; parent, brother, or <span class="hlt">sister</span>. An individual who is the miner...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol3/pdf/CFR-2011-title20-vol3-sec725-225.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol3/pdf/CFR-2011-title20-vol3-sec725-225.pdf"><span>20 CFR 725.225 - Determination of dependency; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of dependency; parent, brother, or <span class="hlt">sister</span>. 725.225 Section 725.225 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.225 Determination of dependency; parent, brother, or <span class="hlt">sister</span>. An individual who is the miner...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/8632802','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/8632802"><span>Cut2 proteolysis required for <span class="hlt">sister</span>-chromatid seperation in fission yeast.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Funabiki, H; Yamano, H; Kumada, K; Nagao, K; Hunt, T; Yanagida, M</p> <p>1996-05-30</p> <p>Although mitotic cyclins are well-known substrates for ubiquitin-mediated proteolysis at the metaphase-anaphase transition, their degradation is not essential for separation of <span class="hlt">sister</span> chromatids; several lines of evidence suggest that proteolysis of other protein(s) is required, however. Here we report the anaphase-specific proteolysis of the Schizosaccharomyces pombe Cut2 protein, which is essential for <span class="hlt">sister</span>-chromatid separation. Cut2 is located in the nucleus, where it is concentrated along the short metaphase spindle. The rapid degradation of Cut2 at anaphase requires its amino-terminal region and the activity of Cut9 (ref. 14), a component of the 20S cyclosome/anaphase-promoting complex (APC), which is necessary for cyclin destruction. Expression of non-degradable Cut2 blocks <span class="hlt">sister</span>-chromatid separation but not cell-cycle progression. This defect can be overcome by grafting the N terminus of cyclin B onto the truncated Cut2, demonstrating that the regulated proteolysis of Cut2 is essential for <span class="hlt">sister</span>-chromatid separation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-215.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-215.pdf"><span>20 CFR 410.215 - Duration of entitlement; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Duration of entitlement; parent, brother, or...; Duration of Entitlement; Filing of Claims and Evidence § 410.215 Duration of entitlement; parent, brother, or <span class="hlt">sister</span>. (a) parent, brother, or <span class="hlt">sister</span> is entitled to benefits beginning with the month all the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-222.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-222.pdf"><span>20 CFR 725.222 - Conditions of entitlement; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Conditions of entitlement; parent, brother... Benefits) § 725.222 Conditions of entitlement; parent, brother, or <span class="hlt">sister</span>. (a) An individual is eligible for benefits as a surviving parent, brother or <span class="hlt">sister</span> if all of the following requirements are met: (1...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-224.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-224.pdf"><span>20 CFR 725.224 - Determination of relationship; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or <span class="hlt">sister</span>. (a) An individual will be considered to be the parent, brother, or <span class="hlt">sister</span> of a miner if the courts of the State in which the miner was...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-03-07/pdf/2012-5533.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-03-07/pdf/2012-5533.pdf"><span>77 FR 13585 - Three <span class="hlt">Sisters</span> Irrigation District; Notice of Application Accepted for Filing and Soliciting...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-03-07</p> <p>...: The proposed Three <span class="hlt">Sisters</span> Irrigation District Hydroelectric Project would be located on the north pipe of the Three <span class="hlt">Sisters</span> Irrigation District's Main Canal Pipeline in Deschutes County, Oregon. The... of Project: The Three <span class="hlt">Sisters</span> Irrigation District Hydroelectric Project would consist of: (1) An...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li class="active"><span>4</span></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_4 --> <div id="page_5" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li class="active"><span>5</span></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="81"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-223.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-223.pdf"><span>20 CFR 725.223 - Duration of entitlement; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or <span class="hlt">sister</span>. (a) A parent, <span class="hlt">sister</span>, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in which...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4224182','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4224182"><span><span class="hlt">Sisters</span> Unbound Is Required for Meiotic Centromeric Cohesion in Drosophila melanogaster</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Krishnan, Badri; Thomas, Sharon E.; Yan, Rihui; Yamada, Hirotsugu; Zhulin, Igor B.; McKee, Bruce D.</p> <p>2014-01-01</p> <p>Regular meiotic chromosome segregation requires <span class="hlt">sister</span> centromeres to mono-orient (orient to the same pole) during the first meiotic division (meiosis I) when homologous chromosomes segregate, and to bi-orient (orient to opposite poles) during the second meiotic division (meiosis II) when <span class="hlt">sister</span> chromatids segregate. Both orientation patterns require cohesion between <span class="hlt">sister</span> centromeres, which is established during meiotic DNA replication and persists until anaphase of meiosis II. Meiotic cohesion is mediated by a conserved four-protein complex called cohesin that includes two structural maintenance of chromosomes (SMC) subunits (SMC1 and SMC3) and two non-SMC subunits. In Drosophila melanogaster, however, the meiotic cohesion apparatus has not been fully characterized and the non-SMC subunits have not been identified. We have identified a novel Drosophila gene called <span class="hlt">sisters</span> unbound (sunn), which is required for stable <span class="hlt">sister</span> chromatid cohesion throughout meiosis. sunn mutations disrupt centromere cohesion during prophase I and cause high frequencies of non-disjunction (NDJ) at both meiotic divisions in both sexes. SUNN co-localizes at centromeres with the cohesion proteins SMC1 and SOLO in both sexes and is necessary for the recruitment of both proteins to centromeres. Although SUNN lacks sequence homology to cohesins, bioinformatic analysis indicates that SUNN may be a structural homolog of the non-SMC cohesin subunit stromalin (SA), suggesting that SUNN may serve as a meiosis-specific cohesin subunit. In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein. PMID:25194162</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11862455','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11862455"><span>Colchicine promotes a change in chromosome structure without loss of <span class="hlt">sister</span> chromatid cohesion in prometaphase I-arrested bivalents.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rodríguez, E M; Parra, M T; Rufas, J S; Suja, J A</p> <p>2001-12-01</p> <p>In somatic cells colchicine promotes the arrest of cell division at prometaphase, and chromosomes show a sequential loss of <span class="hlt">sister</span> chromatid arm and centromere cohesion. In this study we used colchicine to analyse possible changes in chromosome structure and <span class="hlt">sister</span> chromatid cohesion in prometaphase I-arrested bivalents of the katydid Pycnogaster cucullata. After silver staining we observed that in colchicine-arrested prometaphase I bivalents, and in contrast to what was found in control bivalents, <span class="hlt">sister</span> kinetochores appeared individualised and <span class="hlt">sister</span> chromatid axes were completely separated all along their length. However, this change in chromosome structure occurred without loss of <span class="hlt">sister</span> chromatid arm cohesion. We also employed the MPM-2 monoclonal antibody against mitotic phosphoproteins on control and colchicine-treated spermatocytes. In control metaphase I bivalents this antibody labelled the tightly associated <span class="hlt">sister</span> kinetochores and the interchromatid domain. By contrast, in colchicine-treated prometaphase I bivalents individualised <span class="hlt">sister</span> kinetochores appeared labelled, but the interchromatid domain did not show labelling. These results support the notion that MPM-2 phosphoproteins, probably DNA topoisomerase IIalpha, located in the interchromatid domain act as "chromosomal staples" associating <span class="hlt">sister</span> chromatid axes in metaphase I bivalents. The disappearance of these chromosomal staples would induce a change in chromosome structure, as reflected by the separation of <span class="hlt">sister</span> kinetochores and <span class="hlt">sister</span> axes, but without a concomitant loss of <span class="hlt">sister</span> chromatid cohesion.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28920724','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28920724"><span>Canadian Military Nurse <span class="hlt">Deaths</span> in the First World War.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dodd, Dianne</p> <p>2017-01-01</p> <p>This paper examines the lives of sixty-one Canadian Nursing <span class="hlt">Sisters</span> who served during the First World War, and whose <span class="hlt">deaths</span> were attributed, more or less equally, to three categories: general illness, Spanish Influenza, and killed in action. The response by Canadian Army Medical Corps (CAMC) physicians to the loss of these early female officers who were, in fact, Canada's first female war casualties, suggests a gendered construction of illness at work in the CAMC. While nurses tried to prove themselves good soldiers, military physicians were quick to attribute their illnesses and <span class="hlt">deaths</span> to horrific war conditions deemed unsuitable for women. This gendered response is particularly evident in how CAMC physicians invoked a causal role for neurasthenia or shell shock for the nurses' poor health. The health profile of these women also suggests that some of these <span class="hlt">deaths</span> might have occurred had these women stayed in Canada, and it encourages future comparative research into <span class="hlt">death</span> rates among physicians and orderlies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5360625','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5360625"><span>A brother and <span class="hlt">sister</span> with breast cancer, BRCA2 mutations and bilateral supernumerary nipples</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Coad, Ryan</p> <p>2017-01-01</p> <p>We describe a 54-year-old man with breast cancer and a BRCA2 mutation who was also found to have bilateral supernumerary nipples. His <span class="hlt">sister</span>, also with a BRCA2 mutation, was diagnosed with breast cancer in her late forties; she also had bilateral supernumerary nipples. We address the significance of breast cancer arising in breast tissue underlying supernumerary nipples; the known association between supernumerary nipples and genitourinary malignancies/malformations and the possible <span class="hlt">link</span> between BRCA2 and supernumerary nipple development. We believe that this is the first described case of the latter. We then outline an approach to further management for supernumerary nipple cases. PMID:28361071</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28444311','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28444311"><span>Expression of ALS/FTD-<span class="hlt">linked</span> mutant CCNF in zebrafish leads to increased cell <span class="hlt">death</span> in the spinal cord and an aberrant motor phenotype.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hogan, Alison L; Don, Emily K; Rayner, Stephanie L; Lee, Albert; Laird, Angela S; Watchon, Maxinne; Winnick, Claire; Tarr, Ingrid S; Morsch, Marco; Fifita, Jennifer A; Gwee, Serene S L; Formella, Isabel; Hortle, Elinor; Yuan, Kristy C; Molloy, Mark P; Williams, Kelly L; Nicholson, Garth A; Chung, Roger S; Blair, Ian P; Cole, Nicholas J</p> <p>2017-07-15</p> <p>Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, fatal neurodegenerative disease characterised by the <span class="hlt">death</span> of upper and lower motor neurons. Approximately 10% of cases have a known family history of ALS and disease-<span class="hlt">linked</span> mutations in multiple genes have been identified. ALS-<span class="hlt">linked</span> mutations in CCNF were recently reported, however the pathogenic mechanisms associated with these mutations are yet to be established. To investigate possible disease mechanisms, we developed in vitro and in vivo models based on an ALS-<span class="hlt">linked</span> missense mutation in CCNF. Proteomic analysis of the in vitro models identified the disruption of several cellular pathways in the mutant model, including caspase-3 mediated cell <span class="hlt">death</span>. Transient overexpression of human CCNF in zebrafish embryos supported this finding, with fish expressing the mutant protein found to have increased levels of cleaved (activated) caspase-3 and increased cell <span class="hlt">death</span> in the spinal cord. The mutant CCNF fish also developed a motor neuron axonopathy consisting of shortened primary motor axons and increased frequency of aberrant axonal branching. Importantly, we demonstrated a significant correlation between the severity of the CCNF-induced axonopathy and a reduced motor response to a light stimulus (photomotor response). This is the first report of an ALS-<span class="hlt">linked</span> CCNF mutation in vivo and taken together with the in vitro model identifies the disruption of cell <span class="hlt">death</span> pathways as a significant consequence of this mutation. Additionally, this study presents a valuable new tool for use in ongoing studies investigating the pathobiology of ALS-<span class="hlt">linked</span> CCNF mutations. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23590349','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23590349"><span>Brother-<span class="hlt">sister</span> incest: data from anonymous computer-assisted self interviews.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stroebel, Sandra S; O'Keefe, Stephen L; Beard, Keith W; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter</p> <p>2013-01-01</p> <p>Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-<span class="hlt">sister</span> incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The other 1,230 served as controls. The victims of brother-<span class="hlt">sister</span> incest had significantly more problematic outcomes than controls on many measures (e.g., more likely than the controls to endorse feeling like damaged goods, thinking that they had suffered psychological injury, and having undergone psychological treatment for childhood sexual abuse). However, victims of brother-<span class="hlt">sister</span> incest also had significantly less problematic outcomes than victims of father-daughter incest on some measures (e.g., significantly less likely than the father-daughter incest victims to endorse feeling like damaged goods, thinking that they had suffered psychological injury, and having undergone psychological treatment for childhood sexual abuse).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.cancer.gov/publications/patient-education/sibling-has-cancer','NCI'); return false;" href="https://www.cancer.gov/publications/patient-education/sibling-has-cancer"><span>When Your Brother or <span class="hlt">Sister</span> Has Cancer</span></a></p> <p><a target="_blank" href="http://www.cancer.gov">Cancer.gov</a></p> <p></p> <p></p> <p>Help when a brother or <span class="hlt">sister</span> has cancer. Learn how families cope and find support when a sibling has cancer. Tips to help you talk with your friends, deal with stress, and take care of your mind and body are also shared.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10718528','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10718528"><span>The life, legacy, and premature <span class="hlt">death</span> of Felix Mendelssohn.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cherington, M; Smith, R; Nielsen, P J</p> <p>1999-01-01</p> <p>Felix Mendelssohn is one of the great classical composers of all time. During his short lifetime in the first half of the nineteenth century, he reached enormous heights as a composer, conductor, and leader in the world of music. Nearly one hundred years after his <span class="hlt">death</span>, the Nazi regime attempted, unsuccessfully, to erase his music and his memory from history. Since the end of World War II, there has been a resurgence in interest in the life and music of Felix Mendelssohn and that of his <span class="hlt">sister</span>, Fanny. Felix Mendelssohn died in 1947 at the age of 38. Both of his <span class="hlt">sisters</span> died suddenly at the ages of 42 and 45. There is insufficient laboratory or post-mortem data to make a medical diagnosis with certainty. However, based on the information available to us, we speculate that Mendelssohn suffered a subarachnoid or intracerebral hemorrhage. The differential diagnosis of familial stroke syndrome is discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5957430','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5957430"><span>Dynamics and control of <span class="hlt">sister</span> kinetochore behavior during the meiotic divisions in Drosophila spermatocytes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2018-01-01</p> <p><span class="hlt">Sister</span> kinetochores are connected to the same spindle pole during meiosis I and to opposite poles during meiosis II. The molecular mechanisms controlling the distinct behavior of <span class="hlt">sister</span> kinetochores during the two meiotic divisions are poorly understood. To study kinetochore behavior during meiosis, we have optimized time lapse imaging with Drosophila spermatocytes, enabling kinetochore tracking with high temporal and spatial resolution through both meiotic divisions. The correct bipolar orientation of chromosomes within the spindle proceeds rapidly during both divisions. Stable bi-orientation of the last chromosome is achieved within ten minutes after the onset of kinetochore-microtubule interactions. Our analyses of mnm and tef mutants, where univalents instead of bivalents are present during meiosis I, indicate that the high efficiency of normal bi-orientation depends on pronounced stabilization of kinetochore attachments to spindle microtubules by the mechanical tension generated by spindle forces upon bi-orientation. Except for occasional brief separation episodes, <span class="hlt">sister</span> kinetochores are so closely associated that they cannot be resolved individually by light microscopy during meiosis I, interkinesis and at the start of meiosis II. Permanent evident separation of <span class="hlt">sister</span> kinetochores during M II depends on spindle forces resulting from bi-orientation. In mnm and tef mutants, <span class="hlt">sister</span> kinetochore separation can be observed already during meiosis I in bi-oriented univalents. Interestingly, however, this <span class="hlt">sister</span> kinetochore separation is delayed until the metaphase to anaphase transition and depends on the Fzy/Cdc20 activator of the anaphase-promoting complex/cyclosome. We propose that univalent bi-orientation in mnm and tef mutants exposes a release of <span class="hlt">sister</span> kinetochore conjunction that occurs also during normal meiosis I in preparation for bi-orientation of dyads during meiosis II. PMID:29734336</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/1585081','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/1585081"><span>Effect of chloramphenicol on <span class="hlt">sister</span> chromatid exchange in bovine fibroblasts.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Arruga, M V; Catalan, J; Moreno, C</p> <p>1992-03-01</p> <p>The genotoxic potential of different chloramphenicol concentrations (5, 20, 40 and 60 micrograms ml-1) was investigated in bovine fibroblast primary lines by <span class="hlt">sister</span> chromatid exchange assay. Chloramphenicol acted for long enough to ensure similar effects to persistent storage in the kidney. In this experiment 10 micrograms ml-1 of 5-bromodeoxyuridine was added for 60 hours for all doses of chloramphenicol and to the control. When the tissue culture cells were exposed to increasing doses, increased numbers of <span class="hlt">sister</span> chromatid exchanges developed. Differences were significantly different to the control.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://medlineplus.gov/magazine/issues/fall08/articles/fall08pg14.html','NIH-MEDLINEPLUS'); return false;" href="https://medlineplus.gov/magazine/issues/fall08/articles/fall08pg14.html"><span>Cochlear Implants Keep Twin <span class="hlt">Sisters</span> Learning, Discovering Together</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... University. Photo: Johns Hopkins University Keep Twin <span class="hlt">Sisters</span> Learning, Discovering Together Mia and Isabelle Jeppsen, 10, share ... her mother, gratefully, "There's the obvious benefit of learning to read, write and communicate with facility and ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=recombination&pg=4&id=EJ384605','ERIC'); return false;" href="https://eric.ed.gov/?q=recombination&pg=4&id=EJ384605"><span>How-to-Do-It: Demonstrating <span class="hlt">Sister</span> Chromatid Exchanges.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Dye, Frank J.</p> <p>1988-01-01</p> <p>Outlines procedures for demonstrating and preparing a permanent slide of <span class="hlt">sister</span> chromatid exchanges and recombination events between the two chromatids of a single chromosome. Provides the name of an additional resource for making preparations of exchanges. (RT)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25230531','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25230531"><span>[The unexplained <span class="hlt">death</span> of Blandine Liszt Ollivier].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mabin, Dominique</p> <p>2014-01-01</p> <p>Franz Liszt's eldest daughter, Blandine Ollivier, died at the age of 26, two months after the birth of her son Daniel. The reasons of that <span class="hlt">death</span> remain obscure. There are contradictions between the asserted good health of Blandine during her pregnancy and what was learnt later on through the publication in French of Richard Wagner's autobiography. He was the husband of Cosima who was herself Blandine's <span class="hlt">sister</span>. We put forward some hypotheses that can be discussed; Blandine would have contracted a serious anemia of pregnancy, unknown, with a streptococcus septicemia in post partum; no sign or symptom in consideration of mastitis carcinosis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=nun+AND+study&pg=2&id=EJ377172','ERIC'); return false;" href="https://eric.ed.gov/?q=nun+AND+study&pg=2&id=EJ377172"><span><span class="hlt">Sisters</span> at Work: Career and Community Changes.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Briody, Elizabeth K.; Sullivan, Teresa A.</p> <p>1988-01-01</p> <p>The authors examine occupational differentiation of U.S. Catholic nuns before and since the Second Vatican Council. Data were collected from interviews with 30 <span class="hlt">sisters</span> representing 11 congregations. The analysis relates the diversification of their careers to changes in ideology and life-style and to the changing demographic and financial status…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5375655','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5375655"><span>The <span class="hlt">Sisters</span> of Mercy in the Crimean War: Lessons for Catholic health care</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Paradis, Mary Raphael; Hart, Edith Mary; O’Brien, Mary Judith</p> <p>2017-01-01</p> <p>In 1856, an appeal went out to nurses in both England and Ireland, and especially to religious nurses, to care for the troops fighting in the Crimean War. The <span class="hlt">Sisters</span> of Mercy, founded in 1831 by Venerable Catherine McAuley, answered that call. This article describes the enormous challenges the <span class="hlt">Sisters</span> faced in that mission, which was a test of their nursing skills, flexibility, organizational ability, and their spirit of mercy. The challenges they faced professionally and as religious <span class="hlt">Sisters</span>, the manner in which they faced those challenges, and their spiritual lives as religious women shaped their ability to give comprehensive care. Some applications are made to the challenges which religious communities and organizations working in health care face in our country at this time. Summary: This article describes the challenges faced by a group of <span class="hlt">Sisters</span> of Mercy from England and Ireland who volunteered to serve as nurses in the Crimean War from 1856 to 1858. Applications are made to challenges which are faced by religious communities and organizations in the current secular healthcare environment. PMID:28392597</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28392597','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28392597"><span>The <span class="hlt">Sisters</span> of Mercy in the Crimean War: Lessons for Catholic health care.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Paradis, Mary Raphael; Hart, Edith Mary; O'Brien, Mary Judith</p> <p>2017-02-01</p> <p>In 1856, an appeal went out to nurses in both England and Ireland, and especially to religious nurses, to care for the troops fighting in the Crimean War. The <span class="hlt">Sisters</span> of Mercy, founded in 1831 by Venerable Catherine McAuley, answered that call. This article describes the enormous challenges the <span class="hlt">Sisters</span> faced in that mission, which was a test of their nursing skills, flexibility, organizational ability, and their spirit of mercy. The challenges they faced professionally and as religious <span class="hlt">Sisters</span>, the manner in which they faced those challenges, and their spiritual lives as religious women shaped their ability to give comprehensive care. Some applications are made to the challenges which religious communities and organizations working in health care face in our country at this time. Summary: This article describes the challenges faced by a group of <span class="hlt">Sisters</span> of Mercy from England and Ireland who volunteered to serve as nurses in the Crimean War from 1856 to 1858. Applications are made to challenges which are faced by religious communities and organizations in the current secular healthcare environment.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ1006059.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ1006059.pdf"><span><span class="hlt">Sister</span> M. Madeleva Wolff, C.S.C.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Petit, M. Loretta</p> <p>2006-01-01</p> <p><span class="hlt">Sister</span> M. Madeleva Wolff, C.S.C., teacher, essayist, poet, and college administrator, through her creative ability and innovative practices made possible major contributions to Catholic education in her lifetime. Without her strong personality and boundless energy, many of her dreams for an ideal college curriculum would not have come to fruition.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/6650568','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/6650568"><span>Perrault's syndrome in two <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bösze, P; Skripeczky, K; Gaál, M; Tóth, A; László, J</p> <p>1983-10-01</p> <p>We report on two <span class="hlt">sisters</span> with Perrault's syndrome, i.e., autosomal recessive ovarian dysgenesis associated with sensorineural deafness. They were deaf-mute and of normal height with a few minor somatic anomalies. Both had streak gonads and an apparently normal female 46,XX chromosome constitution. The parents were apparently not consanguineous. The mother had normal hearing. Other relatives were not available for study. Epilepsy, which occurred in three relatives including one of the index patients, may have been inherited coincidentally from the mother's family.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3208311','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3208311"><span>Non-redundant odor coding by <span class="hlt">sister</span> mitral cells revealed by light addressable glomeruli in the mouse</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dhawale, Ashesh K.; Hagiwara, Akari; Bhalla, Upinder S.; Murthy, Venkatesh N.; Albeanu, Dinu F.</p> <p>2011-01-01</p> <p>Sensory inputs frequently converge on the brain in a spatially organized manner, often with overlapping inputs to multiple target neurons. Whether the responses of target neurons with common inputs become decorrelated depends on the contribution of local circuit interactions. We addressed this issue in the olfactory system using newly generated transgenic mice expressing channelrhodopsin-2 in all olfactory sensory neurons. By selectively stimulating individual glomeruli with light, we identified mitral/tufted (M/T) cells that receive common input (<span class="hlt">sister</span> cells). <span class="hlt">Sister</span> M/T cells had highly correlated responses to odors as measured by average spike rates, but their spike timing in relation to respiration was differentially altered. In contrast, non-<span class="hlt">sister</span> M/T cells correlated poorly on both these measures. We suggest that <span class="hlt">sister</span> M/T cells carry two different channels of information: average activity representing shared glomerular input, and phase-specific information that refines odor representations and is substantially independent for <span class="hlt">sister</span> M/T cells. PMID:20953197</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li class="active"><span>5</span></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_5 --> <div id="page_6" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active"><span>6</span></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="101"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED332415.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED332415.pdf"><span>Brothers and <span class="hlt">Sisters</span> of Children with Disabilities: An Annotated Bibliography. Families as Allies Project.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Smieja, Linda L.; And Others</p> <p></p> <p>This annotated bibliography provides a comprehensive review of literature focusing on brothers and <span class="hlt">sisters</span> of children with emotional disorders. Some material addressing brothers and <span class="hlt">sisters</span> of children who have physical, mental, or developmental disabilities is also included. The bibliography lists approximately 80 references covering a 10-year…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/5060660-sister-chromatid-exchanges-induced-inhaled-anesthetics','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/5060660-sister-chromatid-exchanges-induced-inhaled-anesthetics"><span><span class="hlt">Sister</span> chromatid exchanges induced by inhaled anesthetics</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>White,A.E.; Takehisa, S.; Eger II, E.I.</p> <p>1970-05-01</p> <p>There is sufficient evidence that anesthetics may cause cancer to justify a test of their carcinogenic potential. Baden et al., using the Ames test, a rapid and inexpensive genetic indicator of carcinogenicity, have shown that among currently used anesthetics fluorxene alone caused bacterial mutations. The authors used the <span class="hlt">sister</span> chromatid exchange (SCE) technique, another rapid assay of mutagenic-carcinogenic potential. The frequency of <span class="hlt">sister</span> chromatid exchanges in Chinese hamster ovary cells increases when the cell cultures are exposed to mutagen-carcinogens, particulary in the presence of a metabolic activating system. With this test system a one-hour exposure to 1 MAC nitrous oxide,more » diethyl ether, trichloroethylene, halothane, enflurane, isoflurane, methoxyflurane, or chloroform did not increase SCE values. Divinyl ether, fluroxene and ethyl vinyl ether increased SCE values in the same circumstances. Results of this study of mammalian cells suggest that no currently used anesthetic is a mutagen-carcinogen. The results also suggest that anesthetics containing a vinyl moiety may be mutagen-carcinogens.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=mental+AND+health+AND+siblings&pg=4&id=EJ626457','ERIC'); return false;" href="https://eric.ed.gov/?q=mental+AND+health+AND+siblings&pg=4&id=EJ626457"><span>Brothers and <span class="hlt">Sisters</span> of Adults with Mental Retardation: Gendered Nature of the Sibling Relationship.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Orsmond, Gael I.; Seltzer, Marsha Mailick</p> <p>2000-01-01</p> <p>Differences and similarities between 245 brothers and <span class="hlt">sisters</span> of adults with mental retardation in the sibling relationship were examined. <span class="hlt">Sisters</span> scored higher in the caregiving, companionship, and positive affect aspects of the sibling relationship. Sibling involvement increased over time, but was dependent upon changes in maternal health.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25194324','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25194324"><span>Identifying possible <span class="hlt">sister</span> groups of Cryptocercidae+Isoptera: a combined molecular and morphological phylogeny of Dictyoptera.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Djernæs, Marie; Klass, Klaus-Dieter; Eggleton, Paul</p> <p>2015-03-01</p> <p>Termites (Isoptera) offer an alternative model for the development of eusociality which is not dependent on a high degree of relatedness as found between <span class="hlt">sisters</span> in hymenopterans (bees, wasps, ants). Recent phylogenetic studies have established that termites belong within the cockroaches as <span class="hlt">sister</span> to the subsocial Cryptocercidae. Cryptocercidae shares several important traits with termites, thus we need to understand the phylogenetic position of Cryptocercidae+Isoptera to determine how these traits evolved. However, placement of Cryptocercidae+Isoptera is still uncertain. We used both molecular (12S, 16S, COII, 18S, 28S, H3) and morphological characters to reconstruct the phylogeny of Dictyoptera. We included all previously suggested <span class="hlt">sister</span> groups of Cryptocercidae+Isoptera as well as taxa which might represent additional major cockroach lineages. We used Bayes factors to test different <span class="hlt">sister</span> groups for Cryptocercidae+Isoptera and assessed character support for the consensus tree based on morphological characters and COII amino acid data. We used the molecular data and fossil calibration to estimate divergence times. We found the most likely <span class="hlt">sister</span> groups of Cryptocercidae+Isoptera to be Tryonicidae, Anaplecta or Tryonicidae+Anaplecta. Anaplecta has never previously been suggested as <span class="hlt">sister</span> group or even close to Cryptocercidae+Isoptera, but was formerly placed in Blaberoidea as <span class="hlt">sister</span> to the remaining taxa. Topological tests firmly supported our new placement of Anaplecta. We discuss the morphological characters (e.g. retractable genitalic hook) that have contributed to the previous placement of Anaplecta in Blaberoidea as well as the factors that might have contributed to a parallel development of genitalic features in Anaplecta and Blaberoidea. Cryptocercidae+Isoptera is placed in a clade with Tryonicidae, Anaplecta and possibly Lamproblattidae. Based on this, we suggest that wood-feeding, and the resultant need to conserve nitrogen, may have been an important</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2567865','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2567865"><span>Shugoshin1 May Play Important Roles in Separation of Homologous Chromosomes and <span class="hlt">Sister</span> Chromatids during Mouse Oocyte Meiosis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Yin, Shen; Ai, Jun-Shu; Shi, Li-Hong; Wei, Liang; Yuan, Ju; Ouyang, Ying-Chun; Hou, Yi; Chen, Da-Yuan; Schatten, Heide; Sun, Qing-Yuan</p> <p>2008-01-01</p> <p>Background Homologous chromosomes separate in meiosis I and <span class="hlt">sister</span> chromatids separate in meiosis II, generating haploid gametes. To address the question why <span class="hlt">sister</span> chromatids do not separate in meiosis I, we explored the roles of Shogoshin1 (Sgo1) in chromosome separation during oocyte meiosis. Methodology/Principal Findings Sgo1 function was evaluated by exogenous overexpression to enhance its roles and RNAi to suppress its roles during two meioses of mouse oocytes. Immunocytochemistry and chromosome spread were used to evaluate phenotypes. The exogenous Sgo1 overexpression kept homologous chromosomes and <span class="hlt">sister</span> chromatids not to separate in meiosis I and meiosis II, respectively, while the Sgo1 RNAi promoted premature separation of <span class="hlt">sister</span> chromatids. Conclusions Our results reveal that prevention of premature separation of <span class="hlt">sister</span> chromatids in meiosis I requires the retention of centromeric Sgo1, while normal separation of <span class="hlt">sister</span> chromatids in meiosis II requires loss of centromeric Sgo1. PMID:18949044</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=freud&id=EJ827914','ERIC'); return false;" href="https://eric.ed.gov/?q=freud&id=EJ827914"><span>Freud on Brothers and <span class="hlt">Sisters</span>: A Neglected Topic</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Sherwin-White, Susan</p> <p>2007-01-01</p> <p>This paper explores Freud's developing thought on brothers and <span class="hlt">sisters</span>, and their importance in his psychoanalytical writings and clinical work. Freud's work on sibling psychology has been seriously undervalued. This paper aims to give due recognition to Freud's work in this area. (Contains 1 note.)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22253761','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22253761"><span>Broad phylogenomic sampling and the <span class="hlt">sister</span> lineage of land plants.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Timme, Ruth E; Bachvaroff, Tsvetan R; Delwiche, Charles F</p> <p>2012-01-01</p> <p>The tremendous diversity of land plants all descended from a single charophyte green alga that colonized the land somewhere between 430 and 470 million years ago. Six orders of charophyte green algae, in addition to embryophytes, comprise the Streptophyta s.l. Previous studies have focused on reconstructing the phylogeny of organisms tied to this key colonization event, but wildly conflicting results have sparked a contentious debate over which lineage gave rise to land plants. The dominant view has been that 'stoneworts,' or Charales, are the <span class="hlt">sister</span> lineage, but an alternative hypothesis supports the Zygnematales (often referred to as "pond scum") as the <span class="hlt">sister</span> lineage. In this paper, we provide a well-supported, 160-nuclear-gene phylogenomic analysis supporting the Zygnematales as the closest living relative to land plants. Our study makes two key contributions to the field: 1) the use of an unbiased method to collect a large set of orthologs from deeply diverging species and 2) the use of these data in determining the <span class="hlt">sister</span> lineage to land plants. We anticipate this updated phylogeny not only will hugely impact lesson plans in introductory biology courses, but also will provide a solid phylogenetic tree for future green-lineage research, whether it be related to plants or green algae.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4107665','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4107665"><span>Influence of PD-L1 cross-<span class="hlt">linking</span> on cell <span class="hlt">death</span> in PD-L1-expressing cell lines and bovine lymphocytes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ikebuchi, Ryoyo; Konnai, Satoru; Okagawa, Tomohiro; Yokoyama, Kazumasa; Nakajima, Chie; Suzuki, Yasuhiko; Murata, Shiro; Ohashi, Kazuhiko</p> <p>2014-01-01</p> <p>Programmed <span class="hlt">death</span>-ligand 1 (PD-L1) blockade is accepted as a novel strategy for the reactivation of exhausted T cells that express programmed <span class="hlt">death</span>-1 (PD-1). However, the mechanism of PD-L1-mediated inhibitory signalling after PD-L1 cross-<span class="hlt">linking</span> by anti-PD-L1 monoclonal antibody (mAb) or PD-1–immunogloblin fusion protein (PD-1-Ig) is still unknown, although it may induce cell <span class="hlt">death</span> of PD-L1+ cells required for regular immune reactions. In this study, PD-1-Ig or anti-PD-L1 mAb treatment was tested in cell lines that expressed PD-L1 and bovine lymphocytes to investigate whether the treatment induces immune reactivation or PD-L1-mediated cell <span class="hlt">death</span>. PD-L1 cross-<span class="hlt">linking</span> by PD-1-Ig or anti-PD-L1 mAb primarily increased the number of dead cells in PD-L1high cells, but not in PD-L1low cells; these cells were prepared from Cos-7 cells in which bovine PD-L1 expression was induced by transfection. The PD-L1-mediated cell <span class="hlt">death</span> also occurred in Cos-7 and HeLa cells transfected with vectors only encoding the extracellular region of PD-L1. In bovine lymphocytes, the anti-PD-L1 mAb treatment up-regulated interferon-γ (IFN-γ) production, whereas PD-1-Ig treatment decreased this cytokine production and cell proliferation. The IFN-γ production in B-cell-depleted peripheral blood mononuclear cells was not reduced by PD-1-Ig treatment and the percentages of dead cells in PD-L1+ B cells were increased by PD-1-Ig treatment, indicating that PD-1-Ig-induced immunosuppression in bovine lymphocytes could be caused by PD-L1-mediated B-cell <span class="hlt">death</span>. This study provides novel information for the understanding of signalling through PD-L1. PMID:24405267</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12470346','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12470346"><span>Incest, gamete donation by siblings and the importance of the genetic <span class="hlt">link</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pennings, G</p> <p>2002-01-01</p> <p>Recently, several requests have emerged in which women wished to be impregnated with donor eggs fertilized with spermatozoa of their brother. An important argument advanced against such applications is that it is a kind of incest. Four definitions of incest are reviewed in this article to evaluate the acceptability of these demands. The first three (sexual intercourse, reproduction with gametes of first-degree relatives and symbolic incest) do not apply to the cases. However, when the <span class="hlt">sister</span> and her brother intend to raise the child as social mother and father, these requests should be considered as "intentional incest". If the brother only functions as an uncle, the request of the woman resembles the currently accepted practice of oocyte donation from <span class="hlt">sister</span> to <span class="hlt">sister</span>. In that case, the wish to receive gametes from a first-degree relative is motivated by the wish to establish as far as possible a genetic <span class="hlt">link</span> with the child.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21838561','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21838561"><span>Psychopathology, childhood trauma, and personality traits in patients with borderline personality disorder and their <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Laporte, Lise; Paris, Joel; Guttman, Herta; Russell, Jennifer</p> <p>2011-08-01</p> <p>The aim of this study was to document and compare adverse childhood experiences, and personality profiles in women with borderline personality disorder (BPD) and their <span class="hlt">sisters</span>, and to determine how these factors impact current psychopathology. Fifty-six patients with BPD and their <span class="hlt">sisters</span> were compared on measures assessing psychopathology, personality traits, and childhood adversities. Most <span class="hlt">sisters</span> showed little evidence of psychopathology. Both groups reported dysfunctional parent-child relationships and a high prevalence of childhood trauma. Subjects with BPD reported experiencing more emotional abuse and intrafamilial sexual abuse, but more similarities than differences between probands and <span class="hlt">sisters</span> were found. In multilevel analyses, personality traits of affective instability and impulsivity predicted DIB-R scores and SCL-90-R scores, above and beyond trauma. There were few relationships between childhood adversities and other measures of psychopathology. Sensitivity to adverse experiences, as reflected in the development of psychopathology, appears to be influenced by personality trait profiles.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12099401','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12099401"><span>Sudden cardiac <span class="hlt">death</span> and geomagnetic activity: <span class="hlt">links</span> to age, gender and agony time.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stoupel, Eliahu; Domarkiene, Stase; Radishauskas, Richardas; Abramson, Evgeny</p> <p>2002-01-01</p> <p>In previous studies, we analyzed sudden cardiac <span class="hlt">death</span> (SCD) of shorter and longer agony time with geomagnetic activity (GMA) levels, with controversial results. The goals of the present study were (1) to study SCD at ages below 65 and 65 and older for each gender on days of low (Io) and higher (IIo-IVo) GMA; (2) to compare <span class="hlt">links</span> between SCD and GMA with <span class="hlt">death</span> at 1 h and from 1 to 24 h. We studied 1327 SCD, 392 (29.5%) females and 935 (70.5%) males, from the Kaunas Registry (part of the MONICA Study): 785 <span class="hlt">deaths</span> during 1826 consecutive days (1994-1998) at ages 25 to 64 years and 524 <span class="hlt">deaths</span> at ages 65 and older during 732 consecutive days (1996-1997). Of these, 261 SCD occurred at 1 h, 1076 between 1 h and 24 h without prodromes. GMA data were obtained from the National Geophysical Data Center and the National Space Services Center, USA. Student t-test and its probabilities for daily SCD at Io and IIo-IVo GMA were compared. The daily number of SCD was significantly different for most of the compared groups at lowest and higher GMA levels. For all SCD, both at age <65 and at >65, the frequency was significantly higher on days of IIo-IVo GMA than on days of Io GMA (p=0.00067-0.03). A strong trend for more SCD on days of Io GMA was seen in males aged <65 who died within 1 h (p=0.06); females aged <65 who died within >1 h to 24 h (p=0.06), and females >65 who died within 1 h (p=0.0267). Females below the age of 65 who died in less than 1 h showed a trend toward higher SCD frequency at IIo-IVo GMA that did not achieve significance (p=0.057). The distribution of SCD, with short (< or =1h) and longer (1-24 h) time of <span class="hlt">death</span>, on days of lowest (Io) GMA differs from that on days of unsettled, active, or stormy (IIo-IVo) GMA. Despite the general trend to higher SCD frequency at IIo-IVo GMA, certain rapidly dying groups (< 65 y males, > 65 y females) showed a strong trend toward higher numbers of SCD at the lowest GMA.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5306525','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5306525"><span>Cause of <span class="hlt">death</span> and potentially avoidable <span class="hlt">deaths</span> in Australian adults with intellectual disability using retrospective <span class="hlt">linked</span> data</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Srasuebkul, Preeyaporn; Xu, Han; Howlett, Sophie</p> <p>2017-01-01</p> <p>Objectives To investigate mortality and its causes in adults over the age of 20 years with intellectual disability (ID). Design, setting and participants Retrospective population-based standardised mortality of the ID and Comparison cohorts. The ID cohort comprised 42 204 individuals who registered for disability services with ID as a primary or secondary diagnosis from 2005 to 2011 in New South Wales (NSW). The Comparison cohort was obtained from published <span class="hlt">deaths</span> in NSW from the Australian Bureau of Statistics (ABS) from 2005 to 2011. Main outcome measures We measured and compared Age Standardised Mortality Rate (ASMR), Comparative Mortality Figure (CMF), years of productive life lost (YPLL) and proportion of <span class="hlt">deaths</span> with potentially avoidable causes in an ID cohort with an NSW general population cohort. Results There were 19 362 adults in the ID cohort which experienced 732 (4%) <span class="hlt">deaths</span> at a median age of 54 years. Age Standardised Mortality Rates increased with age for both cohorts. Overall comparative mortality figure was 1.3, but was substantially higher for the 20–44 (4.0) and 45–64 (2.3) age groups. YPLL was 137/1000 people in the ID cohort and 49 in the comparison cohort. Cause of <span class="hlt">death</span> in ID cohort was dominated by respiratory, circulatory, neoplasm and nervous system. After recoding <span class="hlt">deaths</span> previously attributed to the aetiology of the disability, 38% of <span class="hlt">deaths</span> in the ID cohort and 17% in the comparison cohort were potentially avoidable. Conclusions Adults with ID experience premature mortality and over-representation of potentially avoidable <span class="hlt">deaths</span>. A national system of reporting of <span class="hlt">deaths</span> in adults with ID is required. Inclusion in health policy and services development and in health promotion programmes is urgently required to address premature <span class="hlt">deaths</span> and health inequalities for adults with ID. PMID:28179413</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27773939','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27773939"><span>An epigenome-wide study of body mass index and DNA methylation in blood using participants from the <span class="hlt">Sister</span> Study cohort.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wilson, L E; Harlid, S; Xu, Z; Sandler, D P; Taylor, J A</p> <p>2017-01-01</p> <p>The relationship between obesity and chronic disease risk is well-established; the underlying biological mechanisms driving this risk increase may include obesity-related epigenetic modifications. To explore this hypothesis, we conducted a genome-wide analysis of DNA methylation and body mass index (BMI) using data from a subset of women in the <span class="hlt">Sister</span> Study. The <span class="hlt">Sister</span> Study is a cohort of 50 884 US women who had a <span class="hlt">sister</span> with breast cancer but were free of breast cancer themselves at enrollment. Study participants completed examinations which included measurements of height and weight, and provided blood samples. Blood DNA methylation data generated with the Illumina Infinium HumanMethylation27 BeadChip array covering 27,589 CpG sites was available for 871 women from a prior study of breast cancer and DNA methylation. To identify differentially methylated CpG sites associated with BMI, we analyzed this methylation data using robust linear regression with adjustment for age and case status. For those CpGs passing the false discovery rate significance level, we examined the association in a replication set comprised of a non-overlapping group of 187 women from the <span class="hlt">Sister</span> Study who had DNA methylation data generated using the Infinium HumanMethylation450 BeadChip array. Analysis of this expanded 450 K array identified additional BMI-associated sites which were investigated with targeted pyrosequencing. Four CpG sites reached genome-wide significance (false discovery rate (FDR) q<0.05) in the discovery set and associations for all four were significant at strict Bonferroni correction in the replication set. An additional 23 sites passed FDR in the replication set and five were replicated by pyrosequencing in the discovery set. Several of the genes identified including ANGPT4, RORC, SOCS3, FSD2, XYLT1, ABCG1, STK39, ASB2 and CRHR2 have been <span class="hlt">linked</span> to obesity and obesity-related chronic diseases. Our findings support the hypothesis that obesity-related epigenetic</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2776007','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2776007"><span>Effect of borax on immune cell proliferation and <span class="hlt">sister</span> chromatid exchange in human chromosomes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pongsavee, Malinee</p> <p>2009-01-01</p> <p>Background Borax is used as a food additive. It becomes toxic when accumulated in the body. It causes vomiting, fatigue and renal failure. Methods The heparinized blood samples from 40 healthy men were studied for the impact of borax toxicity on immune cell proliferation (lymphocyte proliferation) and <span class="hlt">sister</span> chromatid exchange in human chromosomes. The MTT assay and <span class="hlt">Sister</span> Chromatid Exchange (SCE) technic were used in this experiment with the borax concentrations of 0.1, 0.15, 0.2, 0.3 and 0.6 mg/ml. Results It showed that the immune cell proliferation (lymphocyte proliferation) was decreased when the concentrations of borax increased. The borax concentration of 0.6 mg/ml had the most effectiveness to the lymphocyte proliferation and had the highest cytotoxicity index (CI). The borax concentrations of 0.15, 0.2, 0.3 and 0.6 mg/ml significantly induced <span class="hlt">sister</span> chromatid exchange in human chromosomes (P < 0.05). Conclusion Borax had effects on immune cell proliferation (lymphocyte proliferation) and induced <span class="hlt">sister</span> chromatid exchange in human chromosomes. Toxicity of borax may lead to cellular toxicity and genetic defect in human. PMID:19878537</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16698532','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16698532"><span><span class="hlt">Sister</span> Mary Joseph's nodule as the first presenting sign of primary fallopian tube adenocarcinoma.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kirshtein, Boris; Meirovitz, Mihai; Okon, Elimelech; Piura, Benjamin</p> <p>2006-01-01</p> <p>Umbilical metastasis (<span class="hlt">Sister</span> Mary Joseph's nodule) is often the first sign of intraabdominal and/or pelvic carcinoma. We describe the fourth case reported in the literature of <span class="hlt">Sister</span> Mary Joseph's nodule originating from fallopian tube carcinoma. In a 54-year-old woman, <span class="hlt">Sister</span> Mary Joseph's nodule was unexpectedly detected during umbilical hernia repair. Subsequent laparoscopy revealed a 2-cm friable tumor located at the fimbriated end of right fallopian tube and 1-cm peritoneal implant in the pouch of Douglas. Laparoscopic bilateral adnexectomy and resection of the peritoneal implant were performed. Because frozen section examination revealed fallopian tube carcinoma, the procedure was continued with laparotomy including total abdominal hysterectomy, omentectomy, and pelvic lymph node sampling. Final diagnosis was stage IIIB fallopian tube carcinoma. The patient received postoperative adjuvant chemotherapy with single-agent carboplatin and has remained alive and with no evidence of disease. It is concluded that in cases of <span class="hlt">Sister</span> Mary Joseph's nodule, laparoscopy can be a useful tool in the search of the primary tumor in the abdomen and/or pelvis. Laparoscopy can provide crucial information with respect to the location, size, and feasibility of optimal surgical resection of the intraabdominal and/or pelvic tumors.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20524537','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20524537"><span>Letters from a suicide: Van Gogh and his <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lester, David</p> <p>2010-04-01</p> <p>An analysis of trends over a 3-yr. period in the letters of Vincent Van Gogh to his <span class="hlt">sister</span> as the time of his suicide approached identified 8 trends, including an increase in words concerned with anxiety and words concerned with the past.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.loc.gov/pictures/collection/hh/item/dc0640.photos.036906p/','SCIGOV-HHH'); return false;" href="https://www.loc.gov/pictures/collection/hh/item/dc0640.photos.036906p/"><span>14. UPPER THREE <span class="hlt">SISTERS</span> FALLS, LOOKING NORTHWEST Photocopy of photograph, ...</span></a></p> <p><a target="_blank" href="http://www.loc.gov/pictures/collection/hh/">Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey</a></p> <p></p> <p></p> <p>14. UPPER THREE <span class="hlt">SISTERS</span> FALLS, LOOKING NORTHWEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=The+AND+Seven+AND+Sisters&id=EJ566969','ERIC'); return false;" href="https://eric.ed.gov/?q=The+AND+Seven+AND+Sisters&id=EJ566969"><span>The Racial Integration of the Seven <span class="hlt">Sister</span> Colleges.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Perkins, Linda M.</p> <p>1998-01-01</p> <p>Although the number of African-American women who attended the elite Seven <span class="hlt">Sisters</span> colleges prior to 1900 was small, these women were highly influential. Early integration is discussed for: (1) Wellesley College; (2) Radcliffe College; (3) Smith College; (4) Mount Holyoke College; (5) Bryn Mawr College; (6) Vassar College; and (7) Barnard College.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5873384','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5873384"><span>Astrocytes expressing ALS‐<span class="hlt">linked</span> mutant FUS induce motor neuron <span class="hlt">death</span> through release of tumor necrosis factor‐alpha</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kia, Azadeh; McAvoy, Kevin; Krishnamurthy, Karthik; Trotti, Davide</p> <p>2018-01-01</p> <p>Mutations in fused in sarcoma (FUS) are <span class="hlt">linked</span> to amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease affecting both upper and lower motor neurons. While it is established that astrocytes contribute to the <span class="hlt">death</span> of motor neurons in ALS, the specific contribution of mutant FUS (mutFUS) through astrocytes has not yet been studied. Here, we used primary astrocytes expressing a N‐terminally GFP tagged R521G mutant or wild‐type FUS (WTFUS) and show that mutFUS‐expressing astrocytes undergo astrogliosis, damage co‐cultured motor neurons via activation of an inflammatory response and produce conditioned medium (ACM) that is toxic to motor neurons in isolation. Time lapse imaging shows that motor neuron cultures exposed to mutFUS ACM, but not WTFUS ACM, undergo significant cell loss, which is preceded by progressive degeneration of neurites. We found that Tumor Necrosis Factor‐Alpha (TNFα) is secreted into ACM of mutFUS‐expressing astrocytes. Accordingly, mutFUS astrocyte‐mediated motor neuron toxicity is blocked by targeting soluble TNFα with neutralizing antibodies. We also found that mutant astrocytes trigger changes to motor neuron AMPA receptors (AMPAR) that render them susceptible to excitotoxicity and AMPAR‐mediated cell <span class="hlt">death</span>. Our data provide the first evidence of astrocytic involvement in FUS‐ALS, identify TNFα as a mediator of this toxicity, and provide several potential therapeutic targets to protect motor neurons in FUS‐<span class="hlt">linked</span> ALS. PMID:29380416</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2008ASPC..389...67A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2008ASPC..389...67A"><span>Creating <span class="hlt">Sister</span> Cities: An Exchange Across Hemispheres</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Adams, M. T.; Cabezon, S. A.; Hardy, E.; Harrison, R. J.</p> <p>2008-06-01</p> <p>Sponsored by Associated Universities, Inc. (AUI) and the National Radio Astronomy Observatory (NRAO), this project creates a cultural and educational exchange program between communities in South and North America, <span class="hlt">linking</span> San Pedro de Atacama in Chile and Magdalena, New Mexico in the United States. Both communities have similar demographics, are in relatively undeveloped regions of high-elevation desert, and are located near major international radio astronomy research facilities. The Atacama Large Millimeter/submillimeter Array (ALMA) is just 40 km east of San Pedro; the Very Large Array (VLA) is just 40 km west of Magdalena. In February 2007, the Mayor of San Pedro and two teachers visited Magdalena for two weeks; in July 2007 three teachers from Magdalena will visit San Pedro. These visits enable the communities to lay the foundation for a permanent, unique partnership. The teachers are sharing expertise and teaching methodologies for physics and astronomy. In addition to creating science education opportunities, this project offers students linguistic and cultural connections. The town of San Pedro, Chile, hosts nearly 100,000 tourists per year, and English language skills are highly valued by local students. Through exchanges enabled by email and distance conferencing, San Pedro and Magdalena students will improve English and Spanish language skills while teaching each other about science and their respective cultures. This poster describes the AUI/NRAO <span class="hlt">Sister</span> Cities program, including the challenges of cross-cultural communication and the rewards of interpersonal exchanges between continents and cultures.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active"><span>6</span></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_6 --> <div id="page_7" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active"><span>7</span></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="121"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26165664','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26165664"><span>Medico legal investigations into sudden sniffing <span class="hlt">deaths</span> <span class="hlt">linked</span> with trichloroethylene.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Da Broi, Ugo; Colatutto, Antonio; Sala, Pierguido; Desinan, Lorenzo</p> <p>2015-08-01</p> <p>Sudden <span class="hlt">deaths</span> attributed to sniffing trichloroethylene are caused by the abuse of this solvent which produces pleasant inebriating effects with rapid dissipation. In the event of repeated cycles of inhalation, a dangerous and uncontrolled systemic accumulation of trichloroethylene may occur, followed by central nervous system depression, coma and lethal cardiorespiratory arrest. Sometimes <span class="hlt">death</span> occurs outside the hospital environment, without medical intervention or witnesses and without specific necroscopic signs. Medico legal investigations into sudden sniffing <span class="hlt">deaths</span> associated with trichloroethylene demand careful analysis of the <span class="hlt">death</span> scene and related circumstances, a detailed understanding of the deceased's medical history and background of substance abuse and an accurate evaluation of all autopsy and laboratory data, with close cooperation between the judiciary, coroners and toxicologists. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28179413','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28179413"><span>Cause of <span class="hlt">death</span> and potentially avoidable <span class="hlt">deaths</span> in Australian adults with intellectual disability using retrospective <span class="hlt">linked</span> data.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Trollor, Julian; Srasuebkul, Preeyaporn; Xu, Han; Howlett, Sophie</p> <p>2017-02-07</p> <p>To investigate mortality and its causes in adults over the age of 20 years with intellectual disability (ID). Retrospective population-based standardised mortality of the ID and Comparison cohorts. The ID cohort comprised 42 204 individuals who registered for disability services with ID as a primary or secondary diagnosis from 2005 to 2011 in New South Wales (NSW). The Comparison cohort was obtained from published <span class="hlt">deaths</span> in NSW from the Australian Bureau of Statistics (ABS) from 2005 to 2011. We measured and compared Age Standardised Mortality Rate (ASMR), Comparative Mortality Figure (CMF), years of productive life lost (YPLL) and proportion of <span class="hlt">deaths</span> with potentially avoidable causes in an ID cohort with an NSW general population cohort. There were 19 362 adults in the ID cohort which experienced 732 (4%) <span class="hlt">deaths</span> at a median age of 54 years. Age Standardised Mortality Rates increased with age for both cohorts. Overall comparative mortality figure was 1.3, but was substantially higher for the 20-44 (4.0) and 45-64 (2.3) age groups. YPLL was 137/1000 people in the ID cohort and 49 in the comparison cohort. Cause of <span class="hlt">death</span> in ID cohort was dominated by respiratory, circulatory, neoplasm and nervous system. After recoding <span class="hlt">deaths</span> previously attributed to the aetiology of the disability, 38% of <span class="hlt">deaths</span> in the ID cohort and 17% in the comparison cohort were potentially avoidable. Adults with ID experience premature mortality and over-representation of potentially avoidable <span class="hlt">deaths</span>. A national system of reporting of <span class="hlt">deaths</span> in adults with ID is required. Inclusion in health policy and services development and in health promotion programmes is urgently required to address premature <span class="hlt">deaths</span> and health inequalities for adults with ID. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21142977','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21142977"><span>Geographic variance of cardiovascular risk factors among community women: the national <span class="hlt">Sister</span> to <span class="hlt">Sister</span> campaign.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Jarvie, Jennifer L; Johnson, Caitlin E; Wang, Yun; Wan, Yun; Aslam, Farhan; Athanasopoulos, Leonidas V; Pollin, Irene; Foody, JoAnne M</p> <p>2011-01-01</p> <p>There are substantial variations in cardiovascular disease (CVD) risk and outcomes among women. We sought to determine geographic variation in risk factor prevalence in a contemporary sample of U.S. women. Using 2008-2009 <span class="hlt">Sister</span> to <span class="hlt">Sister</span> (STS) free heart screening data from 17 U.S. cities, we compared rates of obesity (body mass index [BMI] ≥30 kg/m(2)), hypertension (HTN ≥140/90 mm Hg), low high-density lipoprotein cholesterol (HDL-C <40 mg/dL), and hyperglycemia (≥126 mg/dL) with national rates. In 18,892 women (mean age 49.8 ± 14.3 years, 37% black, 32% white, 14% Hispanic), compared to overall STS rates, significantly higher rates were observed for obesity in Baltimore (42.4%), Atlanta (40.0%), Dallas (37.9%), and Jacksonville (36.0%); for HTN in Atlanta (43.9%), Baltimore (42.5%), and New York (39.1%); for hyperglycemia in Jacksonville (20.3%), Philadelphia (18.1%), and Tampa (17.8%); and for HDL-C <40 mg/dL in Phoenix (37.4%), Dallas (26.5%), and Jacksonville (18.1%). Compared to national American Heart Association (AHA) 2010 update rates, most STS cities had higher rates of hyperglycemia and low HDL-C. In a large, community-based sample of women nationwide, this comprehensive analysis shows remarkable geographic variation in risk factors, which provides opportunities to improve and reduce a woman's CVD risk. Further investigation is required to understand the reasons behind such variation, which will provide insight toward tailoring preventive interventions to narrow gaps in CVD risk reduction in women.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18688790','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18688790"><span><span class="hlt">Sisters</span> in hereditary breast and ovarian cancer families: communal coping, social integration, and psychological well-being.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Koehly, Laura M; Peters, June A; Kuhn, Natalia; Hoskins, Lindsey; Letocha, Anne; Kenen, Regina; Loud, Jennifer; Greene, Mark H</p> <p>2008-08-01</p> <p>We investigated the association between psychological distress and indices of social integration and communal coping among <span class="hlt">sisters</span> from hereditary breast and ovarian cancer (HBOC) families. Sixty-five <span class="hlt">sisters</span> from 31 HBOC families completed the Brief Symptom Inventory-18 and the Colored Eco-Genetic Relationship Map, which identified members of participants' social support networks. Hierarchical linear models were used for all analyses to account for the clustering of <span class="hlt">sisters</span> within families. Intra-family correlation coefficients suggested that <span class="hlt">sisters</span> shared perceptions of breast cancer risk and worry, but not ovarian cancer risk and worry. Further, <span class="hlt">sisters</span> demonstrated shared levels of anxiety and somatization, but not depressive symptoms. Communal coping indices quantifying shared support resources were negatively related to anxiety and somatization. The number of persons with whom cancer risk information was shared exhibited a positive trend with somatization. Social integration, as measured by the size of participants' emotional support network, was negatively associated with anxiety. Lower depression scores were observed among participants with more persons playing multiple support roles and fewer persons providing tangible assistance. Understanding how support relationships impact well-being among persons adjusting to HBOC risk, and the particular role of family in that process, will facilitate developing appropriate management approaches to help cancer-prone families adjust to their cancer risk.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1651138','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1651138"><span>On the feasibility of <span class="hlt">linking</span> census samples to the National <span class="hlt">Death</span> Index for epidemiologic studies: a progress report.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Rogot, E; Feinleib, M; Ockay, K A; Schwartz, S H; Bilgrad, R; Patterson, J E</p> <p>1983-01-01</p> <p>To test the feasibility of using large national probability samples provided by the US Census Bureau, a pilot project was initiated to <span class="hlt">link</span> 230,000 Census-type records to the National <span class="hlt">Death</span> Index (NDI). Using strict precautions to maintain the complete confidentiality of individual records, the Current Population Survey files of one month in 1973 and one month in 1978 were matched by computer to the 1979 NDI file. The basic question to be addressed was whether <span class="hlt">deaths</span> so obtained are seriously underestimated when there is no Social Security Number (SSN) in the Census record. The search of the NDI file resulted in 5,542 matches of which about 1,800 appear to be "true positives" representing <span class="hlt">deaths</span>, the remainder are "false positives." Of the <span class="hlt">deaths</span>, 80 per cent would still have been detected without SSN in the Census record. The main reasons for missing <span class="hlt">deaths</span> (false negatives) were discrepancies in the year of birth and in the given name. Assuming certain changes in the NDI matching algorithm, the 80 per cent figure could increase to 85 per cent or higher; however, this could also cause significant increases in the number of false positives. The National Heart, Lung and Blood Institute (NHLBI) and Census Bureau staff are currently developing a probabilistic method to eliminate false positives from the NDI output tape. The results of the pilot study indicate that a larger research project is clearly feasible. PMID:6625029</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4286542','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4286542"><span>Polyoma small T antigen triggers cell <span class="hlt">death</span> via mitotic catastrophe</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fernando, Arun T Pores; Andrabi, Shaida; Cizmecioglu, Onur; Zhu, Cailei; Livingston, David M.; Higgins, Jonathan M.G; Schaffhausen, Brian S; Roberts, Thomas M</p> <p>2014-01-01</p> <p>Polyoma small T antigen (PyST), an early gene product of the polyoma virus, has been shown to cause cell <span class="hlt">death</span> in a number of mammalian cells in a protein phosphatase 2A (PP2A)-dependent manner. In the current study, using a cell line featuring regulated expression of PyST, we found that PyST arrests cells in mitosis. Live-cell and immunofluorescence studies showed that the majority of the PyST-expressing cells were arrested in prometaphase with almost no cells progressing beyond metaphase. These cells exhibited defects in chromosomal congression, <span class="hlt">sister</span> chromatid cohesion and spindle positioning, resulting in the activation of the Spindle Assembly Checkpoint (SAC). Prolonged mitotic arrest then led to cell <span class="hlt">death</span> via mitotic catastrophe. Cell cycle inhibitors that block cells in G1/S prevented PyST-induced <span class="hlt">death</span>. PyST-induced cell <span class="hlt">death</span> that occurs during M is not dependent on p53 status. These data suggested, and our results confirmed that, PP2A inhibition could be used to preferentially kill cancer cells with p53 mutations that proliferate normally in the presence of cell cycle inhibitors. PMID:24998850</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27591947','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27591947"><span>The <span class="hlt">link</span> between <span class="hlt">death</span> anxiety and post-traumatic symptomatology during terror: Direct <span class="hlt">links</span> and possible moderators.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hamama-Raz, Yaira; Mahat-Shamir, Michal; Pitcho-Prelorentzos, Shani; Zaken, Adi; David, Udi Y; Ben-Ezra, Menachem; Bergman, Yoav S</p> <p>2016-11-30</p> <p>The current wave of terrorism which is taking place in Israel is characterized by increased arbitrary attacks by individual terrorists, acting independently, with reduced ability to anticipate when and where the next attack will take place. This situation creates an atmosphere of fear and insecurity in the lives of many citizens. Accordingly, the current study aims to establish a connection between <span class="hlt">death</span> anxiety and PTSD symptom severity, as well as to examine whether major personality characteristics may moderate this connection. Using an online survey, 429 adult participants were recruited, and filled out <span class="hlt">death</span> anxiety and PTSD symptomatology scales, as well as a short version of the Big Five personality scale. Findings revealed that <span class="hlt">death</span> anxiety was a significant predictor of posttraumatic symptom severity, as were personality characteristics. Moreover, two personality traits, emotional stability and conscientiousness, moderated the association between <span class="hlt">death</span> anxiety and PTSD symptomatology. The importance of <span class="hlt">death</span> anxiety as a factor which is associated with PTSD symptomatology is discussed. Copyright © 2016. Published by Elsevier Ireland Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23883091','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23883091"><span>Wolfgang Amadeus Mozart: the <span class="hlt">death</span> of a genius.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hatzinger, Martin; Hatzinger, Jurgen; Sohn, Michael</p> <p>2013-01-01</p> <p>The early and unexpected <span class="hlt">death</span> of Wolfgang Amadeus Mozart (Salzburg, 1756 - Vienna, 1791) was a mystery from the very first day and the subject of wildest speculations and adventurous assertions. Over the last 100 years, medical science has investigated the physical sufferings and the mysterious <span class="hlt">death</span> of Mozart with increasing intensity. The aim of this article was to recreate Mozart's pathography relying on the his correspondence with father Leopold and <span class="hlt">sister</span> Nannerl and on reports from his physicians and contemporaries. The rumour that Mozart was poisoned followed shortly after his <span class="hlt">death</span> on 5 December 1791, at the age of 35, and has survived to this day. The alleged culprits were his physician van Swieten, Mozart's freemasons lodge, and the Imperial Chapel Master Salieri. Mozart however died of chronic kidney disease and ultimately of uraemia. If kidney damage reaches a critical point, even a minimum additional stress can lead to its failure. This usually occurs in the fourth decade of life. Next time we listen to Mozart, we should remember that this apparently happy person was actually a precocious boy, ripped of his childhood, whose short life was an endless chain of complaints, fatigue, misery, concern, and malady.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24851802','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24851802"><span>Childhood obsessive-compulsive traits in anorexia nervosa patients, their unaffected <span class="hlt">sisters</span> and healthy controls: a retrospective study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Degortes, Daniela; Zanetti, Tatiana; Tenconi, Elena; Santonastaso, Paolo; Favaro, Angela</p> <p>2014-07-01</p> <p>Although there is evidence that childhood perfectionistic traits predate the onset of eating disorders, few studies to date have examined the prevalence and clinical correlates of these traits in patients with anorexia nervosa (AN) and their unaffected <span class="hlt">sisters</span>. The aim of this work was to study the prevalence of childhood obsessive-compulsive traits in patients with lifetime AN, their unaffected <span class="hlt">sisters</span> and healthy women. A total of 116 AN patients, 32 healthy <span class="hlt">sisters</span> and 119 controls were assessed by the EATATE Interview to assess traits such as perfectionism, inflexibility, rule-bound traits, drive for order and symmetry, and excessive doubt and cautiousness. Both self-report and maternal reports were collected. AN patients reported more childhood obsessive-compulsive traits than their healthy <span class="hlt">sisters</span> and controls. In contrast, no differences between healthy controls and unaffected <span class="hlt">sisters</span> emerged. In patients with AN, a dose-response relationship was found between the number of childhood obsessive-compulsive traits and psychopathology, including body image distortion, thus indicating that these traits are an important feature to be considered in assessing and treating eating disorders. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.loc.gov/pictures/collection/hh/item/dc0640.photos.036900p/','SCIGOV-HHH'); return false;" href="https://www.loc.gov/pictures/collection/hh/item/dc0640.photos.036900p/"><span>8. STREAMSIDE PATH NEAR MIDDLE OF THREE <span class="hlt">SISTERS</span> FALLS, LOOKING ...</span></a></p> <p><a target="_blank" href="http://www.loc.gov/pictures/collection/hh/">Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey</a></p> <p></p> <p></p> <p>8. STREAM-SIDE PATH NEAR MIDDLE OF THREE <span class="hlt">SISTERS</span> FALLS, LOOKING WEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4302726','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4302726"><span>A Sibling <span class="hlt">Death</span> in the Family: Common and Consequential</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fletcher, Jason; Mailick, Marsha; Song, Jieun</p> <p>2015-01-01</p> <p>Although a large literature analyzes the determinants of child mortality and suggests policy and medical interventions aimed at its reduction, there is little existing analysis illuminating the consequences of child mortality for other family members. In particular, there is little evidence exploring the consequences of experiencing the <span class="hlt">death</span> of a sibling on one’s own development and transition to adulthood. This article examines the prevalence and consequences of experiencing a sibling <span class="hlt">death</span> during one’s childhood using two U.S. data sets. We show that even in a rich developed country, these experiences are quite common, affecting between 5 % and 8 % of the children with one or more siblings in our two data sets. We then show that these experiences are associated with important reductions in years of schooling as well as a broad range of adult socioeconomic outcomes. Our findings also suggest that <span class="hlt">sisters</span> are far more affected than brothers and that the cause of <span class="hlt">death</span> is an important factor in sibling effects. Overall, our findings point to important previously unexamined consequences of child mortality, adding to the societal costs associated with childhood mortality as well as suggesting additional benefits from policy and medical innovations aimed at curbing both such <span class="hlt">deaths</span> and subsequent effects on family members. PMID:23073753</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=improvement+AND+products&pg=3&id=EJ667313','ERIC'); return false;" href="https://eric.ed.gov/?q=improvement+AND+products&pg=3&id=EJ667313"><span>Clinical Design Sciences: A View from <span class="hlt">Sister</span> Design Efforts.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Zaritsky, Raul; Kelly, Anthony E.; Flowers, Woodie; Rogers, Everett; O'Neill, Patrick</p> <p>2003-01-01</p> <p>Asserts that the social sciences are clinical-like endeavors, and the way that "<span class="hlt">sister</span>" fields discover and validate their results may inform research practice in education. Describes three fields of design that confront similar societal demands for improvement (engineering product design, research on the diffusion of innovations, and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3125979','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3125979"><span><span class="hlt">Sisters</span> in hereditary breast and ovarian cancer families: communal coping, social integration, and psychological well-being†</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Koehly, Laura M.; Peters, June A.; Kuhn, Natalia; Hoskins, Lindsey; Letocha, Anne; Kenen, Regina; Loud, Jennifer; Greene, Mark H.</p> <p>2011-01-01</p> <p>Objective We investigated the association between psychological distress and indices of social integration and communal coping among <span class="hlt">sisters</span> from hereditary breast and ovarian cancer (HBOC) families. Sample and methods Sixty-five <span class="hlt">sisters</span> from 31 HBOC families completed the Brief Symptom Inventory-18 and the Colored Eco-Genetic Relationship Map, which identified members of participants’ social support networks. Hierarchical linear models were used for all analyses to account for the clustering of <span class="hlt">sisters</span> within families. Results Intra-family correlation coefficients suggested that <span class="hlt">sisters</span> shared perceptions of breast cancer risk and worry, but not ovarian cancer risk and worry. Further, <span class="hlt">sisters</span> demonstrated shared levels of anxiety and somatization, but not depressive symptoms. Communal coping indices quantifying shared support resources were negatively related to anxiety and somatization. The number of persons with whom cancer risk information was shared exhibited a positive trend with somatization. Social integration, as measured by the size of participants’ emotional support network, was negatively associated with anxiety. Lower depression scores were observed among participants with more persons playing multiple support roles and fewer persons providing tangible assistance. Conclusion Understanding how support relationships impact well-being among persons adjusting to HBOC risk, and the particular role of family in that process, will facilitate developing appropriate management approaches to help cancer-prone families adjust to their cancer risk. Published in 2008 by John Wiley & Sons Ltd. PMID:18688790</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.loc.gov/pictures/collection/hh/item/dc0640.photos.036899p/','SCIGOV-HHH'); return false;" href="https://www.loc.gov/pictures/collection/hh/item/dc0640.photos.036899p/"><span>7. STREAMSIDE PATH BETWEEN THREE BRIDGE FALLS AND THREE <span class="hlt">SISTERS</span> ...</span></a></p> <p><a target="_blank" href="http://www.loc.gov/pictures/collection/hh/">Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey</a></p> <p></p> <p></p> <p>7. STREAM-SIDE PATH BETWEEN THREE BRIDGE FALLS AND THREE <span class="hlt">SISTERS</span> FALLS, LOOKING WEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21595367','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21595367"><span>An illness in the family: Dr. Maude Abbott and her <span class="hlt">sister</span>, Alice Abbott.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Brookes, Barbara</p> <p>2011-01-01</p> <p>This paper explores Maude Abbott's internationally significant career in medicine and her parallel commitment to caring for her <span class="hlt">sister</span>, Alice Abbott. An examination of Abbott's life reveals the difficulties faced by an ambitious Canadian woman in medicine from the 1890s to the 1920s; difficulties compounded by caring for a <span class="hlt">sister</span> with a mental illness. The Abbott archive suggests that it was far more difficult for a woman doctor to make the kind of sharp distinction between public and private life that might be expected of professional men.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4653290','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4653290"><span>Elevated CO2 Reduced Floret <span class="hlt">Death</span> in Wheat Under Warmer Average Temperatures and Terminal Drought</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dias de Oliveira, Eduardo; Palta, Jairo A.; Bramley, Helen; Stefanova, Katia; Siddique, Kadambot H. M.</p> <p>2015-01-01</p> <p>Elevated CO2 often increases grain yield in wheat by enhancing grain number per ear, which can result from an increase in the potential number of florets or a reduction in the <span class="hlt">death</span> of developed florets. The hypotheses that elevated CO2 reduces floret <span class="hlt">death</span> rather than increases floret development, and that grain size in a genotype with more grains per unit area is limited by the rate of grain filling, were tested in a pair of <span class="hlt">sister</span> lines contrasting in tillering capacity (restricted- vs. free-tillering). The hypotheses were tested under elevated CO2, combined with +3°C above ambient temperature and terminal drought, using specialized field tunnel houses. Elevated CO2 increased net leaf photosynthetic rates and likely the availability of carbon assimilates, which significantly reduced the rates of floret <span class="hlt">death</span> and increased the potential number of grains at anthesis in both <span class="hlt">sister</span> lines by an average of 42%. The restricted-tillering line had faster grain-filling rates than the free-tillering line because the free-tillering line had more grains to fill. Furthermore, grain-filling rates were faster under elevated CO2 and +3°C above ambient. Terminal drought reduced grain yield in both lines by 19%. Elevated CO2 alone increased the potential number of grains, but a trade-off in yield components limited grain yield in the free-tillering line. This emphasizes the need for breeding cultivars with a greater potential number of florets, since this was not affected by the predicted future climate variables. PMID:26635837</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26123545','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26123545"><span>Extensive range overlap between heliconiine <span class="hlt">sister</span> species: evidence for sympatric speciation in butterflies?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rosser, Neil; Kozak, Krzysztof M; Phillimore, Albert B; Mallet, James</p> <p>2015-06-30</p> <p>Sympatric speciation is today generally viewed as plausible, and some well-supported examples exist, but its relative contribution to biodiversity remains to be established. We here quantify geographic overlap of <span class="hlt">sister</span> species of heliconiine butterflies, and use age-range correlations and spatial simulations of the geography of speciation to infer the frequency of sympatric speciation. We also test whether shifts in mimetic wing colour pattern, host plant use and climate niche play a role in speciation, and whether such shifts are associated with sympatry. Approximately a third of all heliconiine <span class="hlt">sister</span> species pairs exhibit near complete range overlap, and analyses of the observed patterns of range overlap suggest that sympatric speciation contributes 32%-95% of speciation events. Müllerian mimicry colour patterns and host plant choice are highly labile traits that seem to be associated with speciation, but we find no association between shifts in these traits and range overlap. In contrast, climatic niches of <span class="hlt">sister</span> species are more conserved. Unlike birds and mammals, <span class="hlt">sister</span> species of heliconiines are often sympatric and our inferences using the most recent comparative methods suggest that sympatric speciation is common. However, if <span class="hlt">sister</span> species spread rapidly into sympatry (e.g. due to their similar climatic niches), then assumptions underlying our methods would be violated. Furthermore, although we find some evidence for the role of ecology in speciation, ecological shifts did not show the associations with range overlap expected under sympatric speciation. We delimit species of heliconiines in three different ways, based on "strict and " "relaxed" biological species concepts (BSC), as well as on a surrogate for the widely-used "diagnostic" version of the phylogenetic species concept (PSC). We show that one reason why more sympatric speciation is inferred in heliconiines than in birds may be due to a different culture of species delimitation in the two</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16457407','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16457407"><span>Sudden unexpected <span class="hlt">death</span> in infancy: place and time of <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Glasgow, J F T; Thompson, A J; Ingram, P J</p> <p>2006-01-01</p> <p>In recent years, many babies who die of Sudden Unexpected <span class="hlt">Death</span> in Infancy (SUDI) in Northern Ireland are found dead in bed--i.e. co-sleeping--with an adult. In order to assess its frequency autopsy reports between April 1996 and August 2001 were reviewed and <span class="hlt">linked</span> to temporal factors. The day and month of <span class="hlt">death</span>, and the place where the baby was found were compared to a reference population of infant <span class="hlt">deaths</span> between one week of age and the second birthday. Although the rate of SUDI was lower than the UK average, 43 cases of SUDI were identified, and two additional <span class="hlt">deaths</span> with virtually identical autopsy findings that were attributed to asphyxia caused by suffocation due to overlaying. Thirty-two of the 45 (71%) were less than four months of age. In 30 of the 45 cases (67%) the history stated that the baby was bed sharing with others; 19 died sleeping in an adult bed, and 11 on a sofa or armchair. In 16 of the 30 (53%) there were at least two other people sharing the sleeping surface, and in one case, three. SUDI was twice as frequent at weekends (found dead Saturday-Monday mornings) compared to weekdays (p<0.02), and significantly more common compared to reference <span class="hlt">deaths</span> (p<0.002). Co-sleeping <span class="hlt">deaths</span> were also more frequent at weekends. Almost half of all SUDI (49%) occurred in the summer months--more than twice the frequency of reference <span class="hlt">deaths</span>. While sharing a place of sleep per se may not increase the risk of <span class="hlt">death</span>, our findings may be <span class="hlt">linked</span> to factors such as habitual smoking, consumption of alcohol or illicit drugs as reported in case-control studies. In advising parents on safer childcare practices, health professionals must be knowledgeable of current research and when, for example, giving advice on co-sleeping this needs to be person-specific cognisant of the risks within a household. New and better means of targeting such information needs to be researched if those with higher risk life-styles are to be positively influenced.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED314204.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED314204.pdf"><span>Early Childhood Injury <span class="hlt">Deaths</span> in Washington State.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Starzyk, Patricia M.</p> <p></p> <p>This paper discusses data on the <span class="hlt">deaths</span> of children aged 1-4 years in Washington State. A two-fold approach was used in the analysis. First, Washington State <span class="hlt">death</span> certificate data for 1979-85 were used to characterize the <span class="hlt">deaths</span> and identify hazardous situations. Second, <span class="hlt">death</span> certificates were <span class="hlt">linked</span> to birth certificates of children born in…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/21043615-nuclear-localized-protein-nulp1-increases-cell-death-human-osteosarcoma-cells-binds-linked-inhibitor-apoptosis-protein','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/21043615-nuclear-localized-protein-nulp1-increases-cell-death-human-osteosarcoma-cells-binds-linked-inhibitor-apoptosis-protein"><span>Nuclear localized protein-1 (Nulp1) increases cell <span class="hlt">death</span> of human osteosarcoma cells and binds the X-<span class="hlt">linked</span> inhibitor of apoptosis protein</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Steen, Hakan; Lindholm, Dan; Minerva Institute for Medical Research, Biomedicum Helsinki, Helsinki</p> <p>2008-02-08</p> <p>Nuclear localized protein-1 (Nulp1) is a recently identified gene expressed in mouse and human tissues particularly during embryonic development. Nulp1 belongs to the family of basic helix-loop-helix (bHLH) proteins that are important in development. The precise function of Nulp1 in cells is however not known. We observed that overexpression of Nulp1 induces a large increase in cell <span class="hlt">death</span> of human osteosarcoma Saos2 cells with DNA fragmentation. In mouse N2A neuroblastoma cells Nulp1 affected cell proliferation and sensitized cells towards <span class="hlt">death</span> induced by staurosporine. Staining using a novel antibody localized Nulp1 mainly to the cell nucleus and to some extent tomore » the cytoplasm. Nulp1 binds the X-<span class="hlt">linked</span> inhibitor of apoptosis protein (XIAP) and this interaction was increased during cell <span class="hlt">death</span>. These results indicate that Nulp1 plays a role in cell <span class="hlt">death</span> control and may influence tumor growth.« less</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active"><span>7</span></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_7 --> <div id="page_8" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active"><span>8</span></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="141"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26174105','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26174105"><span>Sudden <span class="hlt">deaths</span> in adult-worn baby carriers: 19 cases.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bergounioux, J; Madre, C; Crucis-Armengaud, A; Briand-Huchet, E; Michard-Lenoir, A P; Patural, H; Dauger, S; Renolleau, S; Teychéne, A M; Henry, S; Biarent, D; Robin, C; Werner, E; Rambaud, C</p> <p>2015-12-01</p> <p>Soft infant carriers such as slings have become extremely popular in the west and are usually considered safe. We report 19 cases of sudden unexpected <span class="hlt">death</span> in infancy (SUDI) <span class="hlt">linked</span> to infant carrier. Most patients were healthy full-term babies less than 3 months of age, and suffocation was the most frequent cause of <span class="hlt">death</span>. Infant carriers represent an underestimated cause of <span class="hlt">death</span> by suffocation in neonates. • Sudden unexpected <span class="hlt">deaths</span> in infancy <span class="hlt">linked</span> to infant carrier have been only sparsely reported. • We report a series of 19 cases strongly suggesting age of less than 3 months as a risk factor and suffocation as the mechanism of <span class="hlt">death</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86942','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86942"><span>Saccharomyces cerevisiae CTF18 and CTF4 Are Required for <span class="hlt">Sister</span> Chromatid Cohesion</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hanna, Joseph S.; Kroll, Evgueny S.; Lundblad, Victoria; Spencer, Forrest A.</p> <p>2001-01-01</p> <p>CTF4 and CTF18 are required for high-fidelity chromosome segregation. Both exhibit genetic and physical ties to replication fork constituents. We find that absence of either CTF4 or CTF18 causes <span class="hlt">sister</span> chromatid cohesion failure and leads to a preanaphase accumulation of cells that depends on the spindle assembly checkpoint. The physical and genetic interactions between CTF4, CTF18, and core components of replication fork complexes observed in this study and others suggest that both gene products act in association with the replication fork to facilitate <span class="hlt">sister</span> chromatid cohesion. We find that Ctf18p, an RFC1-like protein, directly interacts with Rfc2p, Rfc3p, Rfc4p, and Rfc5p. However, Ctf18p is not a component of biochemically purified proliferating cell nuclear antigen loading RF-C, suggesting the presence of a discrete complex containing Ctf18p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. Recent identification and characterization of the budding yeast polymerase κ, encoded by TRF4, strongly supports a hypothesis that the DNA replication machinery is required for proper <span class="hlt">sister</span> chromatid cohesion. Analogous to the polymerase switching role of the bacterial and human RF-C complexes, we propose that budding yeast RF-CCTF18 may be involved in a polymerase switch event that facilities <span class="hlt">sister</span> chromatid cohesion. The requirement for CTF4 and CTF18 in robust cohesion identifies novel roles for replication accessory proteins in this process. PMID:11287619</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/6596678-manifestations-linked-congenital-stationary-night-blindness-three-daughters-affected-male-demonstration-homozygosity','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/6596678-manifestations-linked-congenital-stationary-night-blindness-three-daughters-affected-male-demonstration-homozygosity"><span>Manifestations of X-<span class="hlt">linked</span> congenital stationary night blindness in three daughters of an affected male: Demonstration of homozygosity</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Bech-Hansen, N.T.; Pearce, W.G.</p> <p>1993-01-01</p> <p>X-<span class="hlt">linked</span> congenital stationary night blindness (CSNB1) is a hereditary retinal disorder in which clinical features in affected males usually include myopia, nystagmus, and impaired visual acuity. Electroretinography demonstrates a marked reduction in b-wave amplitude. In the study of a large Mennonite family with CSNB1, three of five <span class="hlt">sisters</span> in one sibship were found to have manifestations of CSNB1. All the sons of these three <span class="hlt">sisters</span> were affected. Each of the two nonmanifesting <span class="hlt">sisters</span> had at least one unaffected son. Analysis of Xp markers in the region Xp21.1-Xp11.22 showed that the two <span class="hlt">sisters</span> who were unaffected had inherited the same maternalmore » X chromosome (i.e., M2). Two of the daughters who manifested with CSNB had inherited the other maternal X chromosome (M1). The third manifesting <span class="hlt">sister</span> inherited a recombinant X chromosome with a crossover between TIMP and DXS255, which suggests that the CSNB1 locus lies proximal to TIMP. One of the affected daughters' sons had inherited the maternal M1 X chromosome, a finding consistent with that chromosome carrying a mutant CSNB gene; the other affected sons inherited the grandfather's X chromosome (i.e., P). Molecular analysis of DNA from three <span class="hlt">sisters</span> with manifestations of CSNB is consistent with their being homozygous at the CSNB1 locus and with their mother being a carrier of CSNB1. 23 refs., 4 figs., 3 tabs.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005NW.....92..586B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005NW.....92..586B"><span>Osteological evidence for <span class="hlt">sister</span> group relationship between pseudo-toothed birds (Aves: Odontopterygiformes) and waterfowls (Anseriformes)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bourdon, Estelle</p> <p>2005-12-01</p> <p>The phylogenetic affinities of the extinct pseudo-toothed birds have remained controversial. Some authors noted that they resemble both pelicans and allies (Pelecaniformes) and tube-nosed birds (Procellariiformes), but assigned them to a distinct taxon, the Odontopterygiformes. In most recent studies, the pseudo-toothed birds are referred to the family Pelagornithidae inside the Pelecaniformes. Here, I perform a cladistic analysis with five taxa of the pseudo-toothed birds including two undescribed new species from the Early Tertiary of Morocco. The present hypothesis strongly supports a <span class="hlt">sister</span> group relationship of pseudo-toothed birds (Odontopterygiformes) and waterfowls (Anseriformes). The Odontoanserae (Odontopterygiformes plus Anseriformes) are the <span class="hlt">sister</span> group of Neoaves. The placement of the landfowls (Galliformes) as the <span class="hlt">sister</span> taxon of all other neognathous birds does not support the consensus view that the Galloanserae (Galliformes plus Anseriformes) are monophyletic.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-08-15/pdf/2012-20067.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-08-15/pdf/2012-20067.pdf"><span>77 FR 48993 - Proposed Collection; Comment Request; The <span class="hlt">Sister</span> Study: A Prospective Study of the Genetic and...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-08-15</p> <p>... Genetic and Environmental Risk Factors for Breast Cancer SUMMARY: In compliance with the requirement of... <span class="hlt">Sister</span> Study: A Prospective Study of the Genetic and Environmental Risk Factors for Breast Cancer. Type... the development of breast cancer in a high-risk cohort of <span class="hlt">sisters</span> of women who have had breast cancer...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18831118','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18831118"><span>Infant welfare, philanthropy and entrepreneurship in Glasgow: <span class="hlt">Sister</span> Laura's Infant Food Company.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Weaver, L T</p> <p>2008-06-01</p> <p>Laura Smith was <span class="hlt">sister</span>-in-charge of the Children's Dispensary in Glasgow from 1897 to 1922. In 1911 she established <span class="hlt">Sister</span> Laura's Infant Food Company to market a special milk formula of her own invention.The directors of the Dispensary were not amused. As the 'outdoor' department of the Royal Hospital for Sick Children (Yorkhill), the Dispensary was at the forefront of efforts to combat child ill health and malnutrition. This paper considers Laura Smith's initiative within the context of the health and care of infants of the time - high infant mortality, public and professional concerns for infant welfare, technological advances in food science, changing recommendations and practices of infant feeding and ambiguous relations between medicine and commerce.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24444548','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24444548"><span><span class="hlt">Sister</span> chromatid exchange, (SCE), High-Frequency Cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sebastià, Natividad; Hervás, David; Almonacid, Miguel; Villaescusa, Juan Ignacio; Soriano, José Miguel; Sahuquillo, Vicenta; Esteban, Valentín; Barquinero, Joan Francesc; Verdú, Gumersindo; Cervera, José; Such, Esperanza; Montoro, Alegría</p> <p>2014-04-01</p> <p>According to the International Agency for Research on Cancer, smoking tobacco is a major cause of cancer in humans. It causes about half of all male cancer <span class="hlt">deaths</span> and an ever increasing number of cancer <span class="hlt">deaths</span> in females. The aim of this study was to establish whether cigarette smoking increases <span class="hlt">sister</span> chromatid exchanges (SCEs) in peripheral blood lymphocytes in two Spanish population groups; light and heavy smokers. The mean number of High-Frequency Cells (HFCs) was determined and, the SCE distribution pattern among the chromosomes was analysed represented by a ratio described below. A local sample of 101 adult smokers (n=48) and non-smokers (n=53), aged from 18 to 49 years, was studied using SCE levels in peripheral lymphocytes. Heavy smoking (≥ 10 cigarettes per day) increased significantly the SCE frequency and the HFC parameters. Neither age nor sex significantly influenced the frequencies in the groups studied. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23099222','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23099222"><span><span class="hlt">Linking</span> definitions, mechanisms, and modeling of drought-induced tree <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Anderegg, William R L; Berry, Joseph A; Field, Christopher B</p> <p>2012-12-01</p> <p>Tree <span class="hlt">death</span> from drought and heat stress is a critical and uncertain component in forest ecosystem responses to a changing climate. Recent research has illuminated how tree mortality is a complex cascade of changes involving interconnected plant systems over multiple timescales. Explicit consideration of the definitions, dynamics, and temporal and biological scales of tree mortality research can guide experimental and modeling approaches. In this review, we draw on the medical literature concerning human <span class="hlt">death</span> to propose a water resource-based approach to tree mortality that considers the tree as a complex organism with a distinct growth strategy. This approach provides insight into mortality mechanisms at the tree and landscape scales and presents promising avenues into modeling tree <span class="hlt">death</span> from drought and temperature stress. Copyright © 2012 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25590598','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25590598"><span>Effect of cause-of-<span class="hlt">death</span> training on agreement between hospital discharge diagnoses and cause of <span class="hlt">death</span> reported, inpatient hospital <span class="hlt">deaths</span>, New York City, 2008-2010.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ong, Paulina; Gambatese, Melissa; Begier, Elizabeth; Zimmerman, Regina; Soto, Antonio; Madsen, Ann</p> <p>2015-01-15</p> <p>Accurate cause-of-<span class="hlt">death</span> reporting is required for mortality data to validly inform public health programming and evaluation. Research demonstrates overreporting of heart disease on New York City <span class="hlt">death</span> certificates. We describe changes in reported causes of <span class="hlt">death</span> following a New York City health department training conducted in 2009 to improve accuracy of cause-of-<span class="hlt">death</span> reporting at 8 hospitals. The objective of our study was to assess the degree to which <span class="hlt">death</span> certificates citing heart disease as cause of <span class="hlt">death</span> agreed with hospital discharge data and the degree to which training improved accuracy of reporting. We analyzed 74,373 <span class="hlt">death</span> certificates for 2008 through 2010 that were <span class="hlt">linked</span> with hospital discharge records for New York City inpatient <span class="hlt">deaths</span> and calculated the proportion of discordant <span class="hlt">deaths</span>, that is, <span class="hlt">death</span> certificates reporting an underlying cause of heart disease with no corresponding discharge record diagnosis. We also summarized top principal diagnoses among discordant reports and calculated the proportion of inpatient <span class="hlt">deaths</span> reporting sepsis, a condition underreported in New York City, to assess whether documentation practices changed in response to clarifications made during the intervention. Citywide discordance between <span class="hlt">death</span> certificates and discharge data decreased from 14.9% in 2008 to 9.6% in 2010 (P < .001), driven by a decrease in discordance at intervention hospitals (20.2% in 2008 to 8.9% in 2010; P < .001). At intervention hospitals, reporting of sepsis increased from 3.7% of inpatient <span class="hlt">deaths</span> in 2008 to 20.6% in 2010 (P < .001). Overreporting of heart disease as cause of <span class="hlt">death</span> declined at intervention hospitals, driving a citywide decline, and sepsis reporting practices changed in accordance with health department training. Researchers should consider the effect of overreporting and data-quality changes when analyzing New York City heart disease mortality trends. Other vital records jurisdictions should employ similar interventions to</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/1060089','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/1060089"><span>Induction by alkylating agents of <span class="hlt">sister</span> chromatid exchanges and chromatid breaks in Fanconi's anemia.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Latt, S A; Stetten, G; Juergens, L A; Buchanan, G R; Gerald, P S</p> <p>1975-10-01</p> <p><span class="hlt">Sister</span> chromatid exchanges, which may reflect chromosome repair in response to certain types of DNA damage, provide a means of investigating the increased chromosome fragility characteristic of Fanconi's anemia. By a recently developed technique using 33258 Hoechst and 5-bromodeoxyuridine, it was observed that the baseline frequency of <span class="hlt">sister</span> chromatid exchanges in phytohemagglutinin-stimulated lymphocytes from four males with Fanconi's anemia differed little from that of normal lymphocytes. However, addition of the bifunctional alkylating agent mitomycin C (0.01 or 0.03 mug/ml) to the Fanconi's anemia cells during culture induces less than half of the increase in exchanges found in identically treated normal lymphocytes. This reduced increment in exchanges in accompanied by a partial suppression of mitosis and a marked increase in chromatid breaks and rearrangements. Many of these events occur at sites of incomplete chromatid interchange. The increase in <span class="hlt">sister</span> chromatid exchanges induced in Fanconi's anemia lymphocytes by the monofunctional alkylating agent ethylmethane sulfonate (0.25 mg/ml) was slightly less than that in normal cells. Lymphocytes from two sets of parents of the patients with Fanconi's anemia exhibited a normal response to alkylating agents, while dermal fibroblasts from two different patients with Fanconi's anemia reacted to mitomycin C with an increase in chromatid breaks, but a nearly normal increment of <span class="hlt">sister</span> chromatid exchanges. The results suggest that chromosomal breaks and rearrangements in Fanconi's anemia lymphocytes may result from a defect in a form of repair of DNA damage.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1128680','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1128680"><span>DNA single strand breakage, DNA adducts, and <span class="hlt">sister</span> chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites in urine of coke oven workers.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Popp, W; Vahrenholz, C; Schell, C; Grimmer, G; Dettbarn, G; Kraus, R; Brauksiepe, A; Schmeling, B; Gutzeit, T; von Bülow, J; Norpoth, K</p> <p>1997-01-01</p> <p>OBJECTIVES: To investigate the specificity of biological monitoring variables (excretion of phenanthrene and pyrene metabolites in urine) and the usefulness of some biomarkers of effect (alkaline filter elution, 32P postlabelling assay, measurement of <span class="hlt">sister</span> chromatid exchange) in workers exposed to polycyclic aromatic hydrocarbons (PAHs). METHODS: 29 coke oven workers and a standardised control group were investigated for frequencies of DNA single strand breakage, DNA protein cross <span class="hlt">links</span> (alkaline filter elution assay), <span class="hlt">sister</span> chromatid exchange, and DNA adducts (32P postlabelling assay) in lymphocytes. Phenanthrene and pyrene metabolites were measured in 24 hour urine samples. 19 different PAHs (including benzo(a)pyrene, pyrene, and phenanthrene) were measured at the workplace by personal air monitoring. The GSTT1 activity in erythrocytes and lymphocyte subpopulations in blood was also measured. RESULTS: Concentrations of phenanthrene, pyrene, and benzo(a)pyrene in air correlated well with the concentration of total PAHs in air; they could be used for comparisons of different workplaces if the emission compositions were known. The measurement of phenanthrene metabolites in urine proved to be a better biological monitoring variable than the measurement of 1-hydroxypyrene. Significantly more DNA strand breaks in lymphocytes of coke oven workers were found (alkaline filter elution assay); the DNA adduct rate was not significantly increased in workers, but correlated with exposure to PAHs in a semiquantitative manner. The number of <span class="hlt">sister</span> chromatid exchanges was lower in coke oven workers but this was not significant; thus counting <span class="hlt">sister</span> chromatid exchanges was not a good variable for biomonitoring of coke oven workers. Also, indications for immunotoxic influences (changes in lymphocyte subpopulations) were found. CONCLUSIONS: The measurement of phenanthrene metabolites in urine seems to be a better biological monitoring variable for exposure to PAHs than</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=339634&Lab=NHEERL&keyword=heart&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50','EPA-EIMS'); return false;" href="https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=339634&Lab=NHEERL&keyword=heart&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50"><span>Exploring <span class="hlt">links</span> between greenspace and sudden unexpected <span class="hlt">death</span>: a spatial analysis</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>Greenspace has been increasingly recognized as having numerous health benefits. However, its effects are unknown concerning sudden unexpected <span class="hlt">death</span> (SUD), commonly referred to as sudden cardiac <span class="hlt">death</span>, which constitutes a large proportion of mortality in the United States. Because...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26387792','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26387792"><span>X-<span class="hlt">linked</span> dominant protoporphyria: The first reported Japanese case.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ninomiya, Yukiko; Kokunai, Yasuhito; Tanizaki, Hideaki; Akasaka, Eijiro; Nakano, Hajime; Moriwaki, Shinichi</p> <p>2016-04-01</p> <p>A 12-year-old boy with photosensitivity since 3 years of age presented with small concavities on both cheeks, the nasal root and the dorsal surface of both hands. According to the clinical features, erythropoietic protoporphyria (EPP) was suspected. Urine and blood samples were tested for porphyrin derivatives, which revealed a markedly elevated level of erythrocyte protoporphyrin (EP) and a diagnosis of EPP was made. The patient's mother had no photosensitivity, however, lesions appearing slightly as small scars were found on the dorsum of her right hand; his elder <span class="hlt">sister</span> and father showed no rash. The EP levels were elevated in samples from his mother and mildly elevated in those from his elder <span class="hlt">sister</span> and father. To obtain a definitive diagnosis, genetic analyses were performed using samples from all family members, which revealed no mutations in the ferrochelatase-encoding gene (FECH), which is responsible for EPP. Instead, a pathological mutation of the 5-aminolevulinic acid synthase-encoding gene (ALAS2) was identified in samples from the patient, his mother and his elder <span class="hlt">sister</span>, confirming a definitive diagnosis of X-<span class="hlt">linked</span> dominant protoporphyria (XLDPP). This is the first Japanese family reported to have XLDPP, demonstrating evidence of the condition in Japan. In addition, because XLDPP is very similar to EPP in its clinical aspects and laboratory findings, a genetic analysis is required for the differential diagnosis. © 2015 Japanese Dermatological Association.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4307833','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4307833"><span>Effect of Cause-of-<span class="hlt">Death</span> Training on Agreement Between Hospital Discharge Diagnoses and Cause of <span class="hlt">Death</span> Reported, Inpatient Hospital <span class="hlt">Deaths</span>, New York City, 2008–2010</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ong, Paulina; Gambatese, Melissa; Begier, Elizabeth; Zimmerman, Regina; Soto, Antonio</p> <p>2015-01-01</p> <p>Introduction Accurate cause-of-<span class="hlt">death</span> reporting is required for mortality data to validly inform public health programming and evaluation. Research demonstrates overreporting of heart disease on New York City <span class="hlt">death</span> certificates. We describe changes in reported causes of <span class="hlt">death</span> following a New York City health department training conducted in 2009 to improve accuracy of cause-of-<span class="hlt">death</span> reporting at 8 hospitals. The objective of our study was to assess the degree to which <span class="hlt">death</span> certificates citing heart disease as cause of <span class="hlt">death</span> agreed with hospital discharge data and the degree to which training improved accuracy of reporting. Methods We analyzed 74,373 <span class="hlt">death</span> certificates for 2008 through 2010 that were <span class="hlt">linked</span> with hospital discharge records for New York City inpatient <span class="hlt">deaths</span> and calculated the proportion of discordant <span class="hlt">deaths</span>, that is, <span class="hlt">death</span> certificates reporting an underlying cause of heart disease with no corresponding discharge record diagnosis. We also summarized top principal diagnoses among discordant reports and calculated the proportion of inpatient <span class="hlt">deaths</span> reporting sepsis, a condition underreported in New York City, to assess whether documentation practices changed in response to clarifications made during the intervention. Results Citywide discordance between <span class="hlt">death</span> certificates and discharge data decreased from 14.9% in 2008 to 9.6% in 2010 (P < .001), driven by a decrease in discordance at intervention hospitals (20.2% in 2008 to 8.9% in 2010; P < .001). At intervention hospitals, reporting of sepsis increased from 3.7% of inpatient <span class="hlt">deaths</span> in 2008 to 20.6% in 2010 (P < .001). Conclusion Overreporting of heart disease as cause of <span class="hlt">death</span> declined at intervention hospitals, driving a citywide decline, and sepsis reporting practices changed in accordance with health department training. Researchers should consider the effect of overreporting and data-quality changes when analyzing New York City heart disease mortality trends. Other vital records jurisdictions</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25194916','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25194916"><span>"Breaking up is hard to do": the formation and resolution of <span class="hlt">sister</span> chromatid intertwines.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Baxter, Jonathan</p> <p>2015-02-13</p> <p>The absolute necessity to resolve every intertwine between the two strands of the DNA double helix provides a massive challenge to the cellular processes that duplicate and segregate chromosomes. Although the overwhelming majority of intertwines between the parental DNA strands are resolved during DNA replication, there are numerous chromosomal contexts where some intertwining is maintained into mitosis. These mitotic <span class="hlt">sister</span> chromatid intertwines (SCIs) can be found as; short regions of unreplicated DNA, fully replicated and intertwined <span class="hlt">sister</span> chromatids--commonly referred to as DNA catenation--and as <span class="hlt">sister</span> chromatid linkages generated by homologous recombination-associated processes. Several overlapping mechanisms, including intra-chromosomal compaction, topoisomerase action and Holliday junction resolvases, ensure that all SCIs are removed before they can prevent normal chromosome segregation. Here, I discuss why some DNA intertwines persist into mitosis and review our current knowledge of the SCI resolution mechanisms that are employed in both prokaryotes and eukaryotes, including how deregulating SCI formation during DNA replication or disrupting the resolution processes may contribute to aneuploidy in cancer. Copyright © 2014 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21479528','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21479528"><span>Bartter syndrome in two <span class="hlt">sisters</span> with a novel mutation of the CLCNKB gene, one with deafness.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Robitaille, Pierre; Merouani, Aicha; He, Ning; Pei, York</p> <p>2011-09-01</p> <p>This article describes two <span class="hlt">sisters</span> with type III Bartter syndrome (BS) due to a novel missense variant of the CLCNKB gene. The phenotypic expression of the disease was very different in these two siblings. In one <span class="hlt">sister</span>, the disease followed a very severe course, especially in the neonatal period and as a toddler. Both the classic symptoms and the biochemical features of the syndrome were striking. In addition, she presented with sensorineural deafness, a complication yet unreported in this subtype of BS In contrast, the least affected <span class="hlt">sister</span> was symptom free and the biochemical features of the disease although present remained discrete throughout the prolonged follow-up. It is suggested that such a difference in the phenotypic expression of the disease is possibly secondary to the modifier effect of a gene and/or results from environmental factor(s).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=sibling+AND+relationship&id=EJ1069817','ERIC'); return false;" href="https://eric.ed.gov/?q=sibling+AND+relationship&id=EJ1069817"><span>Adult Sibling Relationships with Brothers and <span class="hlt">Sisters</span> with Severe Disabilities</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rossetti, Zach; Hall, Sarah</p> <p>2015-01-01</p> <p>The purpose of this qualitative study was to examine perceptions of adult sibling relationships with a brother or <span class="hlt">sister</span> with severe disabilities and the contexts affecting the relationships. Adult siblings without disabilities (N = 79) from 19 to 72 years of age completed an online survey with four open-ended questions about their relationship…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26968083','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26968083"><span>A possible <span class="hlt">link</span> between life and <span class="hlt">death</span> of a xeric tree in desert.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Xu, Gui-Qing; McDowell, Nate G; Li, Yan</p> <p>2016-05-01</p> <p>Understanding the interactions between drought and tree ontogeny or size remains an essential research priority because size-specific mortality patterns have large impacts on ecosystem structure and function, determine forest carbon storage capacity, and are sensitive to climatic change. Here we investigate a xerophytic tree species (Haloxylon ammodendron (C.A. Mey.)) with which the changes in biomass allocation with tree size may play an important role in size-specific mortality patterns. Size-related changes in biomass allocation, root distribution, plant water status, gas exchange, hydraulic architecture and non-structural carbohydrate reserves of this xerophytic tree species were investigated to assess their potential role in the observed U-shaped mortality pattern. We found that excessively negative water potentials (<-4.7MPa, beyond the P50leaf of -4.1MPa) during prolonged drought in young trees lead to hydraulic failure; while the imbalance of photoassimilate allocation between leaf and root system in larger trees, accompanied with declining C reserves (<2% dry matter across four tissues), might have led to carbon starvation. The drought-resistance strategy of this species is preferential biomass allocation to the roots to improve water capture. In young trees, the drought-resistance strategy is not well developed, and hydraulic failure appears to be the dominant driver of mortality during drought. With old trees, excess root growth at the expense of leaf area may lead to carbon starvation during prolonged drought. Our results suggest that the drought-resistance strategy of this xeric tree is closely <span class="hlt">linked</span> to its life and <span class="hlt">death</span>: well-developed drought-resistance strategy means life, while underdeveloped or overdeveloped drought-resistance strategy means <span class="hlt">death</span>. Copyright © 2016 Elsevier GmbH. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3511620','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3511620"><span>Accuracy and reliability of self-reported weight and height in the <span class="hlt">Sister</span> Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lin, Cynthia J; DeRoo, Lisa A; Jacobs, Sara R; Sandler, Dale P</p> <p>2012-01-01</p> <p>Objective To assess accuracy and reliability of self-reported weight and height and identify factors associated with reporting accuracy. Design Analysis of self-reported and measured weight and height from participants in the <span class="hlt">Sister</span> Study (2003–2009), a nationwide cohort of 50,884 women aged 35–74 in the United States with a <span class="hlt">sister</span> with breast cancer. Setting Weight and height were reported via computer-assisted telephone interview (CATI) and self-administered questionnaires, and measured by examiners. Subjects Early enrollees in the <span class="hlt">Sister</span> Study. There were 18,639 women available for the accuracy analyses and 13,316 for the reliability analyses. Results Using weighted kappa statistics, comparisons were made between CATI responses and examiner measures to assess accuracy and CATI and questionnaire responses to assess reliability. Polytomous logistic regression evaluated factors associated with over- or under-reporting. Compared to measured values, agreement was 96% for reported height (±1 inch; weighted kappa 0.84) and 67% for weight (±3 pounds; weighted kappa 0.92). Obese women [body mass index (BMI) ≥30 kg/m2)] were more likely than normal weight women to under-report weight by ≥5% and underweight women (BMI <18.5 kg/m2) were more likely to over-report. Among normal and overweight women (18.5 kgm2≤ BMI <30 kgm2), weight cycling and lifetime weight difference ≥50 pounds were associated with over-reporting. Conclusions U.S. women in the <span class="hlt">Sister</span> Study were reasonably reliable and accurate in reporting weight and height. Women with normal-range BMI reported most accurately. Overweight and obese women and those with weight fluctuations were less accurate, but even among obese women, few under-reported their weight by >10%. PMID:22152926</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23259587','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23259587"><span>High prevalence of metabolic syndrome in young Hispanic women: findings from the national <span class="hlt">Sister</span> to <span class="hlt">Sister</span> campaign.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rodriguez, Fátima; Naderi, Sahar; Wang, Yun; Johnson, Caitlin E; Foody, JoAnne M</p> <p>2013-04-01</p> <p>Hispanics are the fastest growing segment of the U.S. population and have a higher prevalence of cardiometabolic risk factors as compared with non-Hispanic whites. Further data suggests that Hispanics have undiagnosed complications of metabolic syndrome, namely diabetes mellitus, at an earlier age. We sought to better understand the epidemiology of metabolic syndrome in Hispanic women using data from a large, community-based health screening program. Using data from the <span class="hlt">Sister</span> to <span class="hlt">Sister</span>: The Women's Heart Health Foundation community health fairs from 2008 to 2009 held in 17 U.S. cities, we sought to characterize how cardiometabolic risk profiles vary across age for women by race and ethnicity. Metabolic syndrome was defined using the updated National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines, which included three or more of the following: Waist circumference ≥35 inches, triglycerides ≥150 mg/dL, high-density lipoprotein (HDL) <50 mg/dL, systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg, or a fasting glucose ≥100 mg/dL. A total of 6843 community women were included in the analyses. Metabolic syndrome had a prevalence of 35%. The risk-adjusted odds ratio for metabolic syndrome in Hispanic women versus white women was 1.7 (95% confidence interval, 1.4, 2.0). Dyslipidemia was the strongest predictor of metabolic syndrome among Hispanic women. This disparity appeared most pronounced for younger women. Additional predictors of metabolic syndrome included black race, increasing age, and smoking. In a large, nationally representative sample of women, we found that metabolic syndrome was highly prevalent among young Hispanic women. Efforts specifically targeted to identifying these high-risk women are necessary to prevent the cardiovascular morbidity and mortality associated with metabolic syndrome.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active"><span>8</span></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_8 --> <div id="page_9" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="161"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-340.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-340.pdf"><span>20 CFR 410.340 - Determination of relationship; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determination of relationship; parent, brother, or <span class="hlt">sister</span>. 410.340 Section 410.340 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=43487&Lab=ORD&keyword=bone&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50','EPA-EIMS'); return false;" href="https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=43487&Lab=ORD&keyword=bone&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50"><span>EVIDENCE FOR THE CHROMOSOMAL REPLICONS AS UNITS OF <span class="hlt">SISTER</span> CHROMATID EXCHANGES</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>Current hypotheses of <span class="hlt">sister</span> chromatid exchange (SCE) formation postulate that sites of SCE induction are associated with active replicons or replicon clusters. We have applied the FCC-SCD technique to in vivo studies of mouse bone marrow cells that have been treated with cycloph...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3659383','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3659383"><span>Narcolepsy with Cataplexy Mimicry: The Strange Case of Two <span class="hlt">Sisters</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pizza, Fabio; Vandi, Stefano; Poli, Francesca; Moghadam, Keivan Kaveh; Franceschini, Christian; Bellucci, Claudia; Cipolli, Carlo; Ingravallo, Francesca; Natalini, Giuliana; Mignot, Emmanuel; Plazzi, Giuseppe</p> <p>2013-01-01</p> <p>We report on two <span class="hlt">sisters</span>, 17 and 12 years of age, with clinical features suggesting narcolepsy with cataplexy (NC): daytime sleepiness, spontaneous and emotionally triggered sudden falls to the ground, and overweight/obesity. MSLT showed borderline sleep latency, with 1 and 0 sleep onset REM periods. HLA typing disclosed the DQB1*0602 allele. Video-polygraphy of the spells ruled out NC diagnosis by demonstrating their easy elicitation by suggestion, with wake EEG, electromyo-graphic persistence of muscle tone, and stable presence of tendon reflexes (i.e., pseudo-cataplexy), together with normal cerebrospinal hypocretin-1 levels. Our cases emphasize the need of a clear depiction of cataplexy pattern at the different ages, the usefulness of examining ictal neurophysiology, and collecting all available disease markers in ambiguous cases. Citation: Pizza F; Vandi S; Poli F; Moghadam KK; Fran-ceschini C; Bellucci C; Cipolli C; Ingravallo F; Natalini G; Mignot E; Plazzi G. Narcolepsy with cataplexy mimicry: the strange case of two <span class="hlt">sisters</span>. J Clin Sleep Med 2013;9(6):611-612. PMID:23772196</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29880909','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29880909"><span>Phylogenetic conservatism of thermal traits explains dispersal limitation and genomic differentiation of Streptomyces <span class="hlt">sister</span>-taxa.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Choudoir, Mallory J; Buckley, Daniel H</p> <p>2018-06-07</p> <p>The latitudinal diversity gradient is a pattern of biogeography observed broadly in plants and animals but largely undocumented in terrestrial microbial systems. Although patterns of microbial biogeography across broad taxonomic scales have been described in a range of contexts, the mechanisms that generate biogeographic patterns between closely related taxa remain incompletely characterized. Adaptive processes are a major driver of microbial biogeography, but there is less understanding of how microbial biogeography and diversification are shaped by dispersal limitation and drift. We recently described a latitudinal diversity gradient of species richness and intraspecific genetic diversity in Streptomyces by using a geographically explicit culture collection. Within this geographically explicit culture collection, we have identified Streptomyces <span class="hlt">sister</span>-taxa whose geographic distribution is delimited by latitude. These <span class="hlt">sister</span>-taxa differ in geographic distribution, genomic diversity, and ecological traits despite having nearly identical SSU rRNA gene sequences. Comparative genomic analysis reveals genomic differentiation of these <span class="hlt">sister</span>-taxa consistent with restricted gene flow across latitude. Furthermore, we show phylogenetic conservatism of thermal traits between the <span class="hlt">sister</span>-taxa suggesting that thermal trait adaptation limits dispersal and gene flow across climate regimes as defined by latitude. Such phylogenetic conservatism of thermal traits is commonly associated with latitudinal diversity gradients for plants and animals. These data provide further support for the hypothesis that the Streptomyces latitudinal diversity gradient was formed as a result of historical demographic processes defined by dispersal limitation and driven by paleoclimate dynamics.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED434287.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED434287.pdf"><span>The Effectiveness of Mentoring for Adolescent Mothers and Their Infants: A Comparative Study between <span class="hlt">Sister</span> Friend and Cal Learn.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tebb, Kathleen P.</p> <p></p> <p>This study evaluated <span class="hlt">Sister</span> Friend, a mentoring program in Yolo County, California, serving low-income adolescent mothers and their infants. The primary objective was to determine if participating in the <span class="hlt">Sister</span> Friend program improved the adolescent mother's parenting class attendance, the home environment, parenting behavior, and child…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29331234','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29331234"><span>Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, <span class="hlt">sisters</span>, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yilmaz, Bulent; Vellanki, Priyathama; Ata, Baris; Yildiz, Bulent Okan</p> <p>2018-02-01</p> <p>To provide an evidence-based assessment of metabolic syndrome, hypertension, and hyperlipidemia in first-degree relatives of women with polycystic ovary syndrome (PCOS). Systematic review and meta-analysis. Not applicable. Mothers, fathers, <span class="hlt">sisters</span>, and brothers of women with and without PCOS. An electronic-based search with the use of PubMed from 1960 to June 2015 and cross-checked references of relevant articles. Metabolic syndrome, hypertension and dyslipidemia, and surrogate markers, including systolic blood pressure (BP), diastolic BP, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Fourteen of 3,346 studies were included in the meta-analysis. Prevalence of the following was significantly increased in relatives of women with PCOS: metabolic syndrome (risk ratio [RR] 1.78 [95% confidence interval 1.37, 2.30] in mothers, 1.43 [1.12, 1.81] in fathers, and 1.50 [1.12, 2.00] in <span class="hlt">sisters</span>), hypertension (RR 1.93 [1.58, 2.35] in fathers, 2.92 [1.92, 4.45] in <span class="hlt">sisters</span>), and dyslipidemia (RR 3.86 [2.54, 5.85] in brothers and 1.29 [1.11, 1.50] in fathers). Moreover, systolic BP (mothers, <span class="hlt">sisters</span>, and brothers), total cholesterol (mothers and <span class="hlt">sisters</span>), low-density lipoprotein cholesterol (<span class="hlt">sisters</span>), and triglycerides (mothers and <span class="hlt">sisters</span>) were significantly higher in first-degree relatives of PCOS probands than in controls. Our results show evidence of clustering for metabolic syndrome, hypertension, and dyslipidemia in mothers, fathers, <span class="hlt">sisters</span>, and brothers of women with PCOS. PROSPERO 2016 CRD42016048557. Copyright © 2017 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15222313','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15222313"><span>The use of convent archival records in medical research: the School <span class="hlt">Sisters</span> of Notre Dame archives and the nun study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Patzwald, Gari-Anne; Wildt, Sister Carol Marie</p> <p>2004-01-01</p> <p>The School <span class="hlt">Sisters</span> of Notre Dame (SSND) archives program in a cooperative system for the arrangement and preservation of the records of the SSND provinces in North America, including records of individual <span class="hlt">sisters</span>. Archival records include autobiographies, school and college transcripts, employment histories, and family socioeconomic data. The Nun Study, a longitudinal study of Alzheimer's disease and aging in 678 SSND <span class="hlt">sisters</span>, compares data extracted from these records with data on late-life cognitive and physical function and postmortem brain neuropathology to explore early life factor that may affect late-life cognitive function and longevity.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=incest&id=EJ1011495','ERIC'); return false;" href="https://eric.ed.gov/?q=incest&id=EJ1011495"><span>Brother-<span class="hlt">Sister</span> Incest: Data from Anonymous Computer-Assisted Self Interviews</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Stroebel, Sandra S.; O'Keefe, Stephen L.; Beard, Keith W.; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter</p> <p>2013-01-01</p> <p>Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-<span class="hlt">sister</span> incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21896763','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21896763"><span>MicroRNAs and phylogenomics resolve the relationships of Tardigrada and suggest that velvet worms are the <span class="hlt">sister</span> group of Arthropoda.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Campbell, Lahcen I; Rota-Stabelli, Omar; Edgecombe, Gregory D; Marchioro, Trevor; Longhorn, Stuart J; Telford, Maximilian J; Philippe, Hervé; Rebecchi, Lorena; Peterson, Kevin J; Pisani, Davide</p> <p>2011-09-20</p> <p>Morphological data traditionally group Tardigrada (water bears), Onychophora (velvet worms), and Arthropoda (e.g., spiders, insects, and their allies) into a monophyletic group of invertebrates with walking appendages known as the Panarthropoda. However, molecular data generally do not support the inclusion of tardigrades within the Panarthropoda, but instead place them closer to Nematoda (roundworms). Here we present results from the analyses of two independent genomic datasets, expressed sequence tags (ESTs) and microRNAs (miRNAs), which congruently resolve the phylogenetic relationships of Tardigrada. Our EST analyses, based on 49,023 amino acid sites from 255 proteins, significantly support a monophyletic Panarthropoda including Tardigrada and suggest a <span class="hlt">sister</span> group relationship between Arthropoda and Onychophora. Using careful experimental manipulations--comparisons of model fit, signal dissection, and taxonomic pruning--we show that support for a Tardigrada + Nematoda group derives from the phylogenetic artifact of long-branch attraction. Our small RNA libraries fully support our EST results; no miRNAs were found to <span class="hlt">link</span> Tardigrada and Nematoda, whereas all panarthropods were found to share one unique miRNA (miR-276). In addition, Onychophora and Arthropoda were found to share a second miRNA (miR-305). Our study confirms the monophyly of the legged ecdysozoans, shows that past support for a Tardigrada + Nematoda group was due to long-branch attraction, and suggests that the velvet worms are the <span class="hlt">sister</span> group to the arthropods.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=moral+AND+enhancement&id=EJ755531','ERIC'); return false;" href="https://eric.ed.gov/?q=moral+AND+enhancement&id=EJ755531"><span>Meanings of Sisterhood and Developmental Disability: Narratives from White Nondisabled <span class="hlt">Sisters</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>McGraw, Lori A.; Walker, Alexis J.</p> <p>2007-01-01</p> <p>Integrating thought from critical feminist and disability theorists via a strategic social constructionist perspective, the authors analyzed 10 in-depth qualitative interviews to begin to understand the dialogue between (a) how nondisabled <span class="hlt">sisters</span> understand themselves and their siblings with developmental disabilities and (b) wider systems of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol2/pdf/CFR-2011-title20-vol2-sec410-380.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol2/pdf/CFR-2011-title20-vol2-sec410-380.pdf"><span>20 CFR 410.380 - Determination of dependency; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Determination of dependency; parent, brother... MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and Dependency § 410.380 Determination of dependency; parent, brother, or <span class="hlt">sister</span>. An individual who is the miner's...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-380.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-380.pdf"><span>20 CFR 410.380 - Determination of dependency; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determination of dependency; parent, brother... MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and Dependency § 410.380 Determination of dependency; parent, brother, or <span class="hlt">sister</span>. An individual who is the miner's...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-214.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-214.pdf"><span>20 CFR 410.214 - Conditions of entitlement; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conditions of entitlement; parent, brother...; Duration of Entitlement; Filing of Claims and Evidence § 410.214 Conditions of entitlement; parent, brother, or <span class="hlt">sister</span>. An individual is entitled to benefits if: (a) Such individual: (1) Is the parent, brother...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/7188765','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/7188765"><span>Sjögren-Larsson syndrome in dizygous twin <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>David, T J</p> <p>1980-01-01</p> <p>Two dizygous twin <span class="hlt">sisters</span> with the Sjögren-Larsson syndrome are described. There was parental consanguinity, and the condition is inherited as an autosomal recessive. The main features are mental retardation, spastic diplegia and ichthyosis. Sensory defects of gums and abnormal facial movements were found in the twins, these being recognised features of the syndrome. It is suggested that the condition may be due to an abnormality of the neural crest.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=solomon&pg=3&id=EJ927986','ERIC'); return false;" href="https://eric.ed.gov/?q=solomon&pg=3&id=EJ927986"><span>Evidence That Thinking about <span class="hlt">Death</span> Relates to Time-Estimation Behavior</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Martens, Andy; Schmeichel, Brandon J.</p> <p>2011-01-01</p> <p>Time and <span class="hlt">death</span> are <span class="hlt">linked</span>--the passing of time brings us closer to <span class="hlt">death</span>. Terror management theory proposes that awareness of <span class="hlt">death</span> represents a potent problem that motivates a variety of psychological defenses (Greenberg, Pyszczynski, & Solomon, 1997). We tested the hypothesis that thinking about <span class="hlt">death</span> motivates elongated perceptions of brief…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=values+AND+school+AND+hidden+AND+curriculum&pg=5&id=EJ546582','ERIC'); return false;" href="https://eric.ed.gov/?q=values+AND+school+AND+hidden+AND+curriculum&pg=5&id=EJ546582"><span>Empowerment, Participation, and Democracy? -- The Hong Kong Big <span class="hlt">Sisters</span>' Guidance Programme.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bottery, Mike; Siu, Shun-Mei</p> <p>1996-01-01</p> <p>Asserts that the Big <span class="hlt">Sisters</span> Programme in Hong Kong provides a good example of a scheme that transcends personal and school issues and facilitates a more participative and democratic view of society. Characterizes the program as a benign form of a "hidden curriculum" and recommends establishing it in secondary schools. (MJP)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=human+AND+resource+AND+management+AND+diversity&pg=6&id=EJ604478','ERIC'); return false;" href="https://eric.ed.gov/?q=human+AND+resource+AND+management+AND+diversity&pg=6&id=EJ604478"><span>"Brothers and <span class="hlt">Sisters</span>": A Novel Way to Teach Human Resources Management.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bumpus, Minnette</p> <p>2000-01-01</p> <p>The novel "Brothers and <span class="hlt">Sisters</span>" by Bebe Moore Campbell was used in a management course to explore human resource management issues, concepts, and theories. The course included prereading and postreading surveys, lecture, book review, and examination. Most of the students (92%) felt the novel was an appropriate way to meet course…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Healthy+AND+organization&pg=2&id=EJ1150329','ERIC'); return false;" href="https://eric.ed.gov/?q=Healthy+AND+organization&pg=2&id=EJ1150329"><span>Exploring Undergraduate Black Womyn's Motivations for Engaging in "<span class="hlt">Sister</span> Circle" Organizations</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Croom, Natasha N.; Beatty, Cameron C.; Acker, Lorraine D.; Butler, Malika</p> <p>2017-01-01</p> <p>The purpose of this critical qualitative inquiry was to explore what motivated undergraduate Black womyn (UBW) to engage in "<span class="hlt">Sister</span> Circle"-type student organizations--or groups that center race and gender. Using a critical race feminist theoretical lens, data were collected through a combination of one-on-one interviews and focus…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20029823','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20029823"><span>A computer case definition for sudden cardiac <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chung, Cecilia P; Murray, Katherine T; Stein, C Michael; Hall, Kathi; Ray, Wayne A</p> <p>2010-06-01</p> <p>To facilitate studies of medications and sudden cardiac <span class="hlt">death</span>, we developed and validated a computer case definition for these <span class="hlt">deaths</span>. The study of community dwelling Tennessee Medicaid enrollees 30-74 years of age utilized a <span class="hlt">linked</span> database with Medicaid inpatient/outpatient files, state <span class="hlt">death</span> certificate files, and a state 'all-payers' hospital discharge file. The computerized case definition was developed from a retrospective cohort study of sudden cardiac <span class="hlt">deaths</span> occurring between 1990 and 1993. Medical records for 926 potential cases had been adjudicated for this study to determine if they met the clinical definition for sudden cardiac <span class="hlt">death</span> occurring in the community and were likely to be due to ventricular tachyarrhythmias. The computerized case definition included <span class="hlt">deaths</span> with (1) no evidence of a terminal hospital admission/nursing home stay in any of the data sources; (2) an underlying cause of <span class="hlt">death</span> code consistent with sudden cardiac <span class="hlt">death</span>; and (3) no terminal procedures inconsistent with unresuscitated cardiac arrest. This definition was validated in an independent sample of 174 adjudicated <span class="hlt">deaths</span> occurring between 1994 and 2005. The positive predictive value of the computer case definition was 86.0% in the development sample and 86.8% in the validation sample. The positive predictive value did not vary materially for <span class="hlt">deaths</span> coded according to the ICO-9 (1994-1998, positive predictive value = 85.1%) or ICD-10 (1999-2005, 87.4%) systems. A computerized Medicaid database, <span class="hlt">linked</span> with <span class="hlt">death</span> certificate files and a state hospital discharge database, can be used for a computer case definition of sudden cardiac <span class="hlt">death</span>. Copyright (c) 2009 John Wiley & Sons, Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27207990','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27207990"><span>Sibling Supporters' Experiences of Giving Support to Siblings Who Have a Brother or a <span class="hlt">Sister</span> With Cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nolbris, Margaretha Jenholt; Nilsson, Stefan</p> <p></p> <p>Siblings of a child with a life-threatening disease, such as cancer, have a right to measures that promote their health and welfare. Siblings may find it hard to understand what is happening to the sick child with cancer and why he or she reacts as he or she does. The aim of the study was to explore sibling supporters' thoughts about the experiences they had in providing support for siblings with a brother or a <span class="hlt">sister</span> with a life-threatening disease such as cancer. All the 12 sibling supporters currently working in Sweden participated in a qualitative, descriptive study from which 5 categories emerged, showing that the sibling supporters supported siblings from diagnosis until possible <span class="hlt">death</span>. They enabled siblings who were in the same situation to meet each other and arranged activities suited to their ages, as well as offering an encouraging environment. To help the siblings, the sibling supporters found it necessary to interact with both the parents and the ward staff. The sibling supporters felt that their support was important and necessary in helping siblings promote their own health both when the sick child was alive and also after his or her <span class="hlt">death</span>. The experience of the sibling supporters was that they listened to the siblings' stories and met them when they were in their crisis. The study confirms that sibling supporters should be a part of the health care team that treat and support the family when a child has cancer.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_9 --> <div id="page_10" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="181"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22611995','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22611995"><span>[The work of Moscow communities of <span class="hlt">Sisters</span> of Charity in own medical institutions].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zorin, K V</p> <p>2011-01-01</p> <p>The article analyses the medical activities of Moscow communities of <span class="hlt">Sisters</span> of Charity in curative and educational institutions organized by the communities themselves. The social ministration of communities on the territory of Moscow is considered.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED452094.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED452094.pdf"><span><span class="hlt">Sisters</span> in Science: Using Sports as a Vehicle for Science Learning.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hammrich, Penny L.; Richardson, Greer M.; Green, Tina Sloan; Livingston, Beverly</p> <p></p> <p>This paper describes a project for upper elementary and middle school minority girl students called the <span class="hlt">Sisters</span> in Sport Science (SISS). The SISS program addresses the needs of urban girls in gaining access to equal education in science and mathematics by using athletics as a vehicle for learning. The program provides a non-competitive and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/6872102','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/6872102"><span>Alkaline DNA fragmentation, DNA disentanglement evaluated viscosimetrically and <span class="hlt">sister</span> chromatid exchanges, after treatment in vivo with nitrofurantoin.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Parodi, S; Pala, M; Russo, P; Balbi, C; Abelmoschi, M L; Taningher, M; Zunino, A; Ottaggio, L; de Ferrari, M; Carbone, A; Santi, L</p> <p>1983-07-01</p> <p>Nitrofurantoin was not positive as a carcinogen in long term assays. In vitro it was positive in some short term tests and negative in others. We have examined Nitrofurantoin for its capability of inducing DNA damage in vivo. With the alkaline elution technique, Nitrofurantoin appeared clearly positive in all the tissues examined (liver, kidney, lung, spleen and bone marrow). In the liver we also observed some cross-<span class="hlt">linking</span> effect. In bone marrow cells Nitrofurantoin was also clearly positive in terms of <span class="hlt">sister</span> chromatid exchanges (SCEs) induction. DNA damage in vivo was also examined with a viscosimetric method, more sensitive than alkaline elution. With this method the results were essentially negative, suggesting that the two methods detect different types of damage. In view of its positivity in many organs and in two short term tests in vivo, the carcinogenic potential of Nitrofurantoin should be reconsidered.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27889450','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27889450"><span>RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold <span class="hlt">Sister</span> Chromatids Together.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Seeber, Andrew; Hegnauer, Anna Maria; Hustedt, Nicole; Deshpande, Ishan; Poli, Jérôme; Eglinger, Jan; Pasero, Philippe; Gut, Heinz; Shinohara, Miki; Hopfner, Karl-Peter; Shimada, Kenji; Gasser, Susan M</p> <p>2016-12-01</p> <p>The Mre11-Rad50-Xrs2 (MRX) complex is related to SMC complexes that form rings capable of holding two distinct DNA strands together. MRX functions at stalled replication forks and double-strand breaks (DSBs). A mutation in the N-terminal OB fold of the 70 kDa subunit of yeast replication protein A, rfa1-t11, abrogates MRX recruitment to both types of DNA damage. The rfa1 mutation is functionally epistatic with loss of any of the MRX subunits for survival of replication fork stress or DSB recovery, although it does not compromise end-resection. High-resolution imaging shows that either the rfa1-t11 or the rad50Δ mutation lets stalled replication forks collapse and allows the separation not only of opposing ends but of <span class="hlt">sister</span> chromatids at breaks. Given that cohesin loss does not provoke visible <span class="hlt">sister</span> separation as long as the RPA-MRX contacts are intact, we conclude that MRX also serves as a structural linchpin holding <span class="hlt">sister</span> chromatids together at breaks. Copyright © 2016 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3179045','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3179045"><span>MicroRNAs and phylogenomics resolve the relationships of Tardigrada and suggest that velvet worms are the <span class="hlt">sister</span> group of Arthropoda</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Campbell, Lahcen I.; Rota-Stabelli, Omar; Edgecombe, Gregory D.; Marchioro, Trevor; Longhorn, Stuart J.; Telford, Maximilian J.; Philippe, Hervé; Rebecchi, Lorena; Peterson, Kevin J.; Pisani, Davide</p> <p>2011-01-01</p> <p>Morphological data traditionally group Tardigrada (water bears), Onychophora (velvet worms), and Arthropoda (e.g., spiders, insects, and their allies) into a monophyletic group of invertebrates with walking appendages known as the Panarthropoda. However, molecular data generally do not support the inclusion of tardigrades within the Panarthropoda, but instead place them closer to Nematoda (roundworms). Here we present results from the analyses of two independent genomic datasets, expressed sequence tags (ESTs) and microRNAs (miRNAs), which congruently resolve the phylogenetic relationships of Tardigrada. Our EST analyses, based on 49,023 amino acid sites from 255 proteins, significantly support a monophyletic Panarthropoda including Tardigrada and suggest a <span class="hlt">sister</span> group relationship between Arthropoda and Onychophora. Using careful experimental manipulations—comparisons of model fit, signal dissection, and taxonomic pruning—we show that support for a Tardigrada + Nematoda group derives from the phylogenetic artifact of long-branch attraction. Our small RNA libraries fully support our EST results; no miRNAs were found to <span class="hlt">link</span> Tardigrada and Nematoda, whereas all panarthropods were found to share one unique miRNA (miR-276). In addition, Onychophora and Arthropoda were found to share a second miRNA (miR-305). Our study confirms the monophyly of the legged ecdysozoans, shows that past support for a Tardigrada + Nematoda group was due to long-branch attraction, and suggests that the velvet worms are the <span class="hlt">sister</span> group to the arthropods. PMID:21896763</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=figure+AND+ground+AND+psychology&pg=2&id=EJ1003992','ERIC'); return false;" href="https://eric.ed.gov/?q=figure+AND+ground+AND+psychology&pg=2&id=EJ1003992"><span>Empirical Psycho-Aesthetics and Her <span class="hlt">Sisters</span>: Substantive and Methodological Issues--Part II</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Konecni, Vladimir J.</p> <p>2013-01-01</p> <p>Empirical psycho-aesthetics is approached in this two-part article from two directions. Part I, which appeared in the Winter 2012 issue of "JAE," addressed definitional and organizational issues, including the field's origins, its relation to "<span class="hlt">sister</span>" disciplines (experimental philosophy, cognitive neuroscience of art, and neuroaesthetics), and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19410348','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19410348"><span>[Familial pulmonary fibrosis in 2 Mexican <span class="hlt">sisters</span> with Hermansky-Pudlak syndrome].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zamora, Ana C; Alonso-Martínez, Delfino; Barrera, Lourdes; Mendoza, Felipe; Gaxiola, Miguel; Carrillo, Guillermo</p> <p>2009-08-01</p> <p>Hermansky-Pudlak syndrome is an autosomal recessive disorder commonly found in individuals of Puerto Rican ancestry. We present 2 cases of familial pulmonary fibrosis in 2 Mexican <span class="hlt">sisters</span> with Hermansky-Pudlak syndrome. Pulmonary fibrosis was biopsy-proven in 1 of the patients. This report shows that Hermansky-Pudlak syndrome may occur in individuals of Mexican ancestry.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=beans&pg=5&id=EJ797780','ERIC'); return false;" href="https://eric.ed.gov/?q=beans&pg=5&id=EJ797780"><span>Three <span class="hlt">Sisters</span>: Lessons of Traditional Story Honored in Assessment and Accreditation</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Chenault, Venida S.</p> <p>2008-01-01</p> <p>The three <span class="hlt">sisters</span> story is shared across many tribes. It explains the practice of planting corn, beans, and squash together. The corn stalks provide support for the bean vines; the beans provide nitrogen for the corn; and the squash prevents weed growth between the mounds. Such stories explain not only the science of agricultural methods in tribal…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27391311','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27391311"><span>Kindler syndrome: the case of two Iranian <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kargar, Saeed; Shiryazdi, Seyed M; Neamatzadeh, Hossein; Ramazani, Vahid</p> <p>2018-02-01</p> <p>Kindler syndrome is a rare autosomal recessive condition, characterized by multiple skin and mucosal abnormalities. Among the latter, esophageal involvement is an infrequent manifestation which may be completely asymptomatic or complicated by dysphagia. We report the case of two <span class="hlt">sisters</span> presenting with cutaneous features and severe dysphagia. Endoscopic examination showed that the patients were affected by a rare condition named "esophageal web". Both patients showed significant improvement after balloon dilation. Clinicians should be aware of the potential complications of this disease, and the approach by balloon dilation should be considered as primary therapy in Kindler syndrome patients with esophageal web.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.fs.usda.gov/treesearch/pubs/29914','TREESEARCH'); return false;" href="https://www.fs.usda.gov/treesearch/pubs/29914"><span><span class="hlt">Linking</span> sudden oak <span class="hlt">death</span> with spatial economic value transfer</span></a></p> <p><a target="_blank" href="http://www.fs.usda.gov/treesearch/">Treesearch</a></p> <p>Tom Holmes; Bill Smith</p> <p>2008-01-01</p> <p>Sudden oak <span class="hlt">death</span> (caused by Phytophthora ramorum) is currently having a dramatic impact on the flow of ecosystem services provided by trees and forests in California. Timber species in California are not thought to be at risk of mortality from this pathogen and, consequently, economic impacts accrue to non-market values of trees such as aesthetics,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19017705','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19017705"><span>Birth weight and fetal growth in infants born to female hairdressers and their <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Axmon, A; Rylander, L</p> <p>2009-03-01</p> <p>To investigate birth weight and fetal growth in female hairdressers, while controlling for intergenerational effects and effects related to childhood exposures. A cohort of women who had attended vocational schools for hairdressers were compared to their <span class="hlt">sisters</span> with respect to birth weight and fetal growth (measured as small for gestational age (SGA) or large for gestational age (LGA), respectively) in their infants. In total, 6223 infants born to 3137 hairdressers and 8388 infants born to 3952 hairdressers' <span class="hlt">sisters</span> were studied. Among the infants born to the hairdressers' <span class="hlt">sisters</span>, the distribution of birth weights were wider than that among the infants born to the hairdressers. This was also reflected in that hairdresser cohort affiliation tended to be protective against both SGA (odds ratio 0.80; 95% confidence interval 0.49 to 1.31) and LGA (0.77; 0.54 to 1.09). For LGA, this effect was even more pronounced among women who had actually worked as hairdressers during at least one pregnancy (0.60; 0.39 to 0.92). The infants born to these women also had a significantly lower mean birth weight (3387 g vs 3419 g; p = 0.033). The results from the present study suggest that infants born to hairdressers have a decreased risk of being LGA. This is most likely not caused by a shift in birth weight distribution or abnormal glucose metabolism.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26040382','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26040382"><span>[Nutritional status of two generations of brothers and <span class="hlt">sisters</span> <5 years of age beneficiaries from opportunities living in marginalized rural communities in Chiapas, Mexico].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>García-Parra, Esmeralda; Ochoa-Díaz-López, Héctor; García-Miranda, Rosario; Moreno-Altamirano, Laura; Morales, Helda; Estrada-Lugo, Erin Ingrid Jane; Solís-Hernández, Roberto</p> <p>2015-06-01</p> <p>Mexico, in recent decades, has developed several programs to eradicate the problem of infant malnutrition <5 years, primarily among those living in rural and indigenous areas. However, there is insufficient evidence on these programs’ impact on child health and nutrition. To describe the nutritional changes of two generations of brothers and <span class="hlt">sisters</span> living in rural communities of Chiapas and who are Oportunidades beneficiaries. Cross-sectional study. It was determined: underweight, stunting, wasting and overweight plus obesity. Older brothers and <span class="hlt">sisters</span> were evaluated in 2002-2003, for 2010-2011 younger brothers and <span class="hlt">sisters</span> were evaluated, both groups were <5 years of age at the time of data collection. Malnutrition, in its three types is a problem. 43.4% of brothers and <span class="hlt">sisters</span> evaluated in 2010-2011 showed stunting, underweight prevalence declined from 18% to 13.2%, wasting (low weight for height) increased from 8.1% to 10.4%. Overweight and obesity increased significantly by 12 percentage points among brothers and <span class="hlt">sisters</span>, from 24.8% in 2002-2003 to 36.8% in 2010-2011. Malnutrition among male children is lower than their brothers and <span class="hlt">sisters</span> from the 2002-2003 generation (stunting p=<0.05), overweight and obesity was 10.9 percentage points higher than their brothers and <span class="hlt">sisters</span> (26.4% to 37.3%). Children beneficiaries from Opportunities have not yet overcome chronic malnutrition problems. This study shows that there is not a clear impact in improving the nutritional status of the study population. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26546904','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26546904"><span>Familial Churg-Strauss Syndrome in a <span class="hlt">Sister</span> and Brother.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Alyasin, Soheyla; Khoshkhui, Maryam; Amin, Reza</p> <p>2015-06-01</p> <p>Churg-Strauss syndrome (CSS) is a granulomatous small vessel vasculitis. It is characterized by asthma, allergic granulomatosis and vasculitis. This syndrome is rare in children. A 5 years old boy was admitted with cough, fever and dyspnea for 2 weeks. On the basis of laboratory data (peripheral eosinophilia), associated with skin biopsy, and history of CSS in his <span class="hlt">sister</span>, this disease was eventually diagnosed. The patient had good response to corticosteroid. In every asthmatic patient with prolonged fever, eosinophilia and multisystemic involvment, CSS should be considered.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24098761','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24098761"><span>Combined inhibition of autophagy and caspases fails to prevent developmental nurse cell <span class="hlt">death</span> in the Drosophila melanogaster ovary.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Peterson, Jeanne S; McCall, Kimberly</p> <p>2013-01-01</p> <p>During the final stages of Drosophila melanogaster oogenesis fifteen nurse cells, <span class="hlt">sister</span> cells to the oocyte, degenerate as part of normal development. This process involves at least two cell <span class="hlt">death</span> mechanisms, caspase-dependent cell <span class="hlt">death</span> and autophagy, as indicated by apoptosis and autophagy markers. In addition, mutations affecting either caspases or autophagy partially reduce nurse cell removal, leaving behind end-stage egg chambers with persisting nurse cell nuclei. To determine whether apoptosis and autophagy work in parallel to degrade and remove these cells as is the case with salivary glands during pupariation, we generated mutants doubly affecting caspases and autophagy. We found no significant increase in either the number of late stage egg chambers containing persisting nuclei or in the number of persisting nuclei per egg chamber in the double mutants compared to single mutants. These findings suggest that there is another cell <span class="hlt">death</span> mechanism functioning in the ovary to remove all nurse cell remnants from late stage egg chambers.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED421602.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED421602.pdf"><span><span class="hlt">Sisters</span> in Science: A Model Program. Spotlight on Student Success, No. 201.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hammrich, Penny L.</p> <p></p> <p>In an effort to promote females' achievement in science, the <span class="hlt">Sisters</span> in Science program was developed. Conducted in 2 schools in Philadelphia (Pennsylvania), the program's inaugural year involved 60 fourth-grade girls in 2 elementary schools, an intergenerational corps of 20 women volunteers, 150 undergraduate elementary education students, and 8…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22773825','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22773825"><span>Fertility drugs and young-onset breast cancer: results from the Two <span class="hlt">Sister</span> Study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fei, Chunyuan; Deroo, Lisa A; Sandler, Dale P; Weinberg, Clarice R</p> <p>2012-07-03</p> <p>Fertility drugs stimulate hyperovulation, which may have implications for breast cancer. We examined the association between use of fertility drugs (clomiphene citrate [CC] and follicle-stimulating hormone [FSH]) and subsequent risk of young-onset (<50 years at diagnosis) breast cancer. We conducted the Two <span class="hlt">Sister</span> Study, a <span class="hlt">sister</span>-matched case-control study, by enrolling 1422 women between September 2008 and December 2010, who were younger than age 50 years at diagnosis with breast cancer and were enrolled within 4 years of diagnosis, and 1669 breast cancer-free control <span class="hlt">sisters</span> from the <span class="hlt">Sister</span> Study. Participants reported their use of fertility drugs (CC and FSH) and ever-users reported whether a pregnancy had resulted that lasted 10 or more (10+) weeks. Conditional logistic regression was used to estimate confounder-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for fertility drug use with or without conception of a 10+ week pregnancy. A total of 288 participants reported having used ovulation-stimulating drugs (193 CC only, 29 FSH only, and 66 both). Overall, women who had used fertility drugs showed a non-statistically significantly decreased risk of breast cancer, compared with nonusers (OR = 0.82, 95% CI = 0.63 to 1.08). Women who had used fertility drugs but had not conceived a 10+ week pregnancy under treatment showed a statistically significantly decreased risk of breast cancer compared with nonusers (OR = 0.62, 95% CI = 0.43 to 0.89). Women who had used fertility drugs and conceived a 10+ week pregnancy under treatment showed a statistically significantly increased risk of breast cancer compared with unsuccessfully treated women (OR = 1.82, 95% CI = 1.10 to 3.00), although their risk was not increased compared with women who had not used fertility drugs (OR = 1.13, 95% CI = 0.78 to 1.64). In the absence of a 10+ week pregnancy under treatment, exposure to ovulation-stimulating fertility drugs was associated with reduced risk of young</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2011-01-04/pdf/2010-33090.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2011-01-04/pdf/2010-33090.pdf"><span>76 FR 315 - <span class="hlt">Sisters</span> Ranger District; Deschutes National Forest; Oregon; Popper Vegetation Management Project</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-01-04</p> <p>... would be located on National Forest System lands south of the city of <span class="hlt">Sisters</span>, Oregon; east of the Three... acre Cascade Timberlands property which is being considered as a future Community Forest. The legal...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4244149','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4244149"><span>Using Ecological Niche Models and Niche Analyses to Understand Speciation Patterns: The Case of <span class="hlt">Sister</span> Neotropical Orchid Bees</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Silva, Daniel P.; Vilela, Bruno; De Marco, Paulo; Nemésio, André</p> <p>2014-01-01</p> <p>The role of past connections between the two major South American forested biomes on current species distribution has been recognized a long time ago. Climatic oscillations that further separated these biomes have promoted parapatric speciation, in which many species had their continuous distribution split, giving rise to different but related species (i.e., different potential distributions and realized niche features). The distribution of many <span class="hlt">sister</span> species of orchid bees follow this pattern. Here, using ecological niche models and niche analyses, we (1) tested the role of ecological niche differentiation on the divergence between <span class="hlt">sister</span> orchid-bees (genera Eulaema and Eufriesea) from the Amazon and Atlantic forests, and (2) highlighted interesting areas for new surveys. Amazonian species occupied different realized niches than their Atlantic <span class="hlt">sister</span> species. Conversely, species of sympatric but distantly related Eulaema bees occupied similar realized niches. Amazonian species had a wide potential distribution in South America, whereas Atlantic Forest species were more limited to the eastern coast of the continent. Additionally, we identified several areas in need of future surveys. Our results show that the realized niche of Atlantic-Amazonian <span class="hlt">sister</span> species of orchid bees, which have been previously treated as allopatric populations of three species, had limited niche overlap and similarity. These findings agree with their current taxonomy, which treats each of those populations as distinct valid species. PMID:25422941</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12185620','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12185620"><span>[No X-chromosome <span class="hlt">linked</span> juvenile foveal retinoschisis].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pérez Alvarez, M J; Clement Fernández, F</p> <p>2002-08-01</p> <p>To describe the clinical characteristics of two cases of juvenile foveal retinoschisis in women with an atypical hereditary pattern, no X-chromosome <span class="hlt">linked</span>. An autosomal recessive inheritance is proposed. Two generations of a family (5 members) in which only two <span class="hlt">sisters</span> were evaluated. The complete examination of these two cases includes retinography, fluorescein angiography, automated perimetry, color vision testing, electroretinogram, electrooculogram and visually evoked potentials. Comparing our cases with the classic form of X-<span class="hlt">linked</span> juvenile retinoschisis, they are less severely affected. The best visual acuity and the less disturbed or even normal electroretinogram confirm this fact. We emphasise the existence of isolated plaques of retinal pigment epithelium atrophy with perivascular pigment clumps without foveal schisis in one patient, which could represent an evolved form of this entity. The hereditary foveal juvenile retinoschisis in women suggests an autosomal inheritance (autosomal recessive in our cases) and presents less severe involvement (Arch Soc Esp Oftalmol 2002; 77: 443-448).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11862488','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11862488"><span>A novel MADS-box gene subfamily with a <span class="hlt">sister</span>-group relationship to class B floral homeotic genes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Becker, A; Kaufmann, K; Freialdenhoven, A; Vincent, C; Li, M-A; Saedler, H; Theissen, G</p> <p>2002-02-01</p> <p>Class B floral homeotic genes specify the identity of petals and stamens during the development of angiosperm flowers. Recently, putative orthologs of these genes have been identified in different gymnosperms. Together, these genes constitute a clade, termed B genes. Here we report that diverse seed plants also contain members of a hitherto unknown <span class="hlt">sister</span> clade of the B genes, termed B(<span class="hlt">sister</span>) (B(s)) genes. We have isolated members of the B(s) clade from the gymnosperm Gnetum gnemon, the monocotyledonous angiosperm Zea mays and the eudicots Arabidopsis thaliana and Antirrhinum majus. In addition, MADS-box genes from the basal angiosperm Asarum europaeum and the eudicot Petunia hybrida were identified as B(s) genes. Comprehensive expression studies revealed that B(s) genes are mainly transcribed in female reproductive organs (ovules and carpel walls). This is in clear contrast to the B genes, which are predominantly expressed in male reproductive organs (and in angiosperm petals). Our data suggest that the B(s) genes played an important role during the evolution of the reproductive structures in seed plants. The establishment of distinct B and B(s) gene lineages after duplication of an ancestral gene may have accompanied the evolution of male microsporophylls and female megasporophylls 400-300 million years ago. During flower evolution, expression of B(s) genes diversified, but the focus of expression remained in female reproductive organs. Our findings imply that a clade of highly conserved close relatives of class B floral homeotic genes has been completely overlooked until recently and awaits further evaluation of its developmental and evolutionary importance. Electronic supplementary material to this paper can be obtained by using the Springer <span class="hlt">Link</span> server located at http://dx.doi.org/10.1007/s00438-001-0615-8.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_10 --> <div id="page_11" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="201"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21875855','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21875855"><span>Clopidogrel discontinuation after acute coronary syndromes: frequency, predictors and associations with <span class="hlt">death</span> and myocardial infarction--a hospital registry-primary care <span class="hlt">linked</span> cohort (MINAP-GPRD).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Boggon, Rachael; van Staa, Tjeerd P; Timmis, Adam; Hemingway, Harry; Ray, Kausik K; Begg, Alan; Emmas, Cathy; Fox, Keith A A</p> <p>2011-10-01</p> <p>Adherence to evidence-based treatments and its consequences after acute myocardial infarction (MI) are poorly defined. We examined the extent to which clopidogrel treatment initiated in hospital is continued in primary care; the factors predictive of clopidogrel discontinuation and the hazard of <span class="hlt">death</span> or recurrent MI. We <span class="hlt">linked</span> the Myocardial Ischaemia National Audit Project registry and the General Practice Research Database to examine adherence to clopidogrel in primary care among patients discharged from hospital after MI (2003-2009). Hospital Episode Statistics and national mortality data were <span class="hlt">linked</span>, documenting all-cause mortality and non-fatal MI. Of the 7543 <span class="hlt">linked</span> patients, 4650 were prescribed clopidogrel in primary care within 3 months of discharge. The adjusted odds of still being prescribed clopidogrel at 12 months were similar following non-ST-elevation myocardial infarction (NSTEMI) 53% (95% CI, 51-55) and ST-elevation myocardial infarction (STEMI) 54% (95% CI, 52-56), but contrast with statins: NSTEMI 84% (95% CI, 82-85) and STEMI 89% (95% CI, 87-90). Discontinuation within 12 months was more frequent in older patients [>80 vs. 40-49 years, adjusted hazard ratio (HR) 1.50 (95% CI, 1.15-1.94)] and with bleeding events [HR 1.34 (95% CI, 1.03-1.73)]. 18.15 patients per 100 person-years (95% CI, 16.83-19.58) died or experienced non-fatal MI in the first year following discharge. In patients who discontinued clopidogrel within 12 months, the adjusted HR for <span class="hlt">death</span> or non-fatal MI was 1.45 (95% CI, 1.22-1.73) compared with untreated patients, and 2.62 (95% CI, 2.17-3.17) compared with patients persisting with clopidogrel treatment. This is the first study to use <span class="hlt">linked</span> registries to determine persistence of clopidogrel treatment after MI in primary care. It demonstrates that discontinuation is common and associated with adverse outcomes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19894428','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19894428"><span>Comparing the National <span class="hlt">Death</span> Index and the Social Security Administration's <span class="hlt">Death</span> Master File to ascertain <span class="hlt">death</span> in HIV surveillance.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hanna, David B; Pfeiffer, Melissa R; Sackoff, Judith E; Selik, Richard M; Begier, Elizabeth M; Torian, Lucia V</p> <p>2009-01-01</p> <p>New York City (NYC) maintains a population-based registry of people with human immunodeficiency virus (HIV) infection to monitor the epidemic and inform resource allocation. We evaluated record linkages with the National <span class="hlt">Death</span> Index (NDI) and the Social Security Administration's <span class="hlt">Death</span> Master File (SSDMF) to find <span class="hlt">deaths</span> occurring from 2000 through 2004. We <span class="hlt">linked</span> records from 32,837 people reported with HIV and not previously known to be dead with <span class="hlt">deaths</span> reported in the NDI and the SSDMF. We calculated the kappa statistic to assess agreement between data sources. We performed subgroup analyses to assess differences within demographic and transmission risk subpopulations. We quantified the benefit of linkages with each data source beyond prior <span class="hlt">death</span> ascertainment from local vital statistics data. We discovered 1,926 (5.87%) <span class="hlt">deaths</span>, which reduced the HIV prevalence estimate in NYC by 2.03%, from 1.19% to 1.16%. Of these, 458 (23.78%) were identified only from NDI, and 305 (15.84%) only from SSDMF. Agreement in ascertainment between sources was substantial (kappa = [K] 0.74, 95% confidence interval [CI] 0.72, 0.76); agreement was lower among Hispanic people (K = 0.65, 95% CI 0.62, 0.69) and people born outside the U.S. (K = 0.60, 95% CI 0.52, 0.68). We identified an additional 13.62% of <span class="hlt">deaths</span> to people reported with HIV in NYC; white people and men who have sex with men were disproportionately likely to be underascertained without these linkages (p < 0.0001). Record linkages with national databases are essential for accurate prevalence estimates from disease registries, and the SSDMF is an inexpensive means to supplement linkages with the NDI to maximize <span class="hlt">death</span> ascertainment.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=drama+AND+mathematics+AND+education&pg=4&id=ED266892','ERIC'); return false;" href="https://eric.ed.gov/?q=drama+AND+mathematics+AND+education&pg=4&id=ED266892"><span>Walking with Grandfather and Great Wolf and Little Mouse <span class="hlt">Sister</span>. Teacher's Guide.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lethbridge Univ. (Alberta).</p> <p></p> <p>Written for use with videotaped versions of the stories "Walking with Grandfather" and "Great Wolf and Little Mouse <span class="hlt">Sister</span>," this guide presents 20 lessons that teachers can adapt for students of various ages and use in integrated units or other curriculum approaches. The introductory material describes the use and philosophy of the video stories,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=death&pg=2&id=EJ1012746','ERIC'); return false;" href="https://eric.ed.gov/?q=death&pg=2&id=EJ1012746"><span><span class="hlt">Deaths</span> among Children, Adolescents, and Young Adults with Down Syndrome</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Miodrag, Nancy; Silverberg, Sophie E.; Urbano, Richard C.; Hodapp, Robert M.</p> <p>2013-01-01</p> <p>Background: Although life expectancies in Down syndrome (DS) have doubled over the past 3-4 decades, there continue to be many early <span class="hlt">deaths</span>. Yet, most research focuses on infant mortality or later adult <span class="hlt">deaths</span>. Materials and Methods: In this US study, hospital discharge and <span class="hlt">death</span> records from the state of Tennessee were <span class="hlt">linked</span> to examine 2046…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28521621','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28521621"><span>Family Member <span class="hlt">Deaths</span> in Childhood Predict Systemic Inflammation in Late Life.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Norton, Maria C; Hatch, Daniel J; Munger, Ronald G; Smith, Ken R</p> <p>2017-01-01</p> <p>Biological and epidemiological evidence has <span class="hlt">linked</span> early-life psychosocial stress with late-life health, with inflammation as a potential mechanism. We report here the association between familial <span class="hlt">death</span> in childhood and adulthood and increased levels of high-sensitivity C-reactive protein (CRP), a marker of systemic inflammation. The Cache County Memory Study is a prospective study of persons initially aged 65 and older in 1995. In 2002, there were 1,955 persons in the study with data on CRP (42.3 percent male, mean [SD] age = 81.2 [5.8] years), <span class="hlt">linked</span> with objective data on family member <span class="hlt">deaths</span>. Using logistic regression, high (> 10 mg/L) versus low (≤ 10 mg/L) CRP was regressed on cumulative parental, sibling, spouse, and offspring <span class="hlt">deaths</span> during childhood and during early adulthood, adjusted for family size in each period (percentage family depletion; PFD). Findings revealed PFD during childhood to be significantly associated with CRP (OR = 1.02, 95% CI [1.01, 1.04]). Individuals with two or more family <span class="hlt">deaths</span> were 79 percent more likely to have elevated CRP than those with zero family <span class="hlt">deaths</span> (OR = 1.79, 95% CI [1.07, 2.99]). Early adulthood PFD was not related to CRP. This study demonstrates a <span class="hlt">link</span> between significant psychosocial stress in early life and immune-inflammatory functioning in late life, and suggests a mechanism explaining the <span class="hlt">link</span> between early-life adversity and late-life health.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16809068','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16809068"><span>Finding the missing <span class="hlt">link</span> between ictal bradyarrhythmia, ictal asystole, and sudden unexpected <span class="hlt">death</span> in epilepsy.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Leung, H; Kwan, P; Elger, C E</p> <p>2006-08-01</p> <p>Basic science studies of the human brain have supported the cortical representation of cardiovascular responses, including heart rate variability. Clinical observations of ictal bradyarrhythmia may be mechanistically explained by the influence of the central autonomic network, although the localization and lateralization issues need to be considered in the light of patterns of seizure spread, hand dominance, and presence of lesions. Ictal bradyarrhythmia also offers a mechanistic explanation of sudden unexpected <span class="hlt">death</span> in epilepsy (SUDEP), though it may explain only some but not all cases of SUDEP. The missing <span class="hlt">links</span> are (1) clinical evidence of common factors shared by patients with ictal bradyarrhythmia and patients who die from SUDEP, (2) evidence of arrhythmia as a risk factor for SUDEP from epidemiological studies, and, (3) determination of the importance of ictal bradyarrhythmia in SUDEP with respect to other proposed mechanisms including apnea and intrinsic cardiac abnormalities. There remains a need to review the seizure mechanisms in cases of SUDEP and to step up the amount of concurrent ECG/intracranial EEG analysis in both ictal bradyarrhythmia and SUDEP cases.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Turner+AND+Syndrome&pg=3&id=EJ579567','ERIC'); return false;" href="https://eric.ed.gov/?q=Turner+AND+Syndrome&pg=3&id=EJ579567"><span>Social Functioning among Girls with Fragile X or Turner Syndrome and Their <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Mazzocco, Michele M. M.; Baumgardner, Thomas; Freund, Lisa S.; Reiss, Allan L.</p> <p>1998-01-01</p> <p>Social behaviors among girls (ages 6-16) with fragile X (n=8) or Turner syndrome (n=9) were examined to address the role of family environment versus biological determinants of social dysfunction. Compared to their <span class="hlt">sisters</span>, subjects had lower IQS and higher rating of social and attention problems. (Author/CR)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23761686','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23761686"><span>Gymnosperm B-<span class="hlt">sister</span> genes may be involved in ovule/seed development and, in some species, in the growth of fleshy fruit-like structures.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lovisetto, Alessandro; Guzzo, Flavia; Busatto, Nicola; Casadoro, Giorgio</p> <p>2013-08-01</p> <p>The evolution of seeds together with the mechanisms related to their dispersal into the environment represented a turning point in the evolution of plants. Seeds are produced by gymnosperms and angiosperms but only the latter have an ovary to be transformed into a fruit. Yet some gymnosperms produce fleshy structures attractive to animals, thus behaving like fruits from a functional point of view. The aim of this work is to increase our knowledge of possible mechanisms common to the development of both gymnosperm and angiosperm fruits. B-<span class="hlt">sister</span> genes from two gymnosperms (Ginkgo biloba and Taxus baccata) were isolated and studied. The Ginkgo gene was also functionally characterized by ectopically expressing it in tobacco. In Ginkgo the fleshy structure derives from the outer seed integument and the B-<span class="hlt">sister</span> gene is involved in its growth. In Taxus the fleshy structure is formed de novo as an outgrowth of the ovule peduncle, and the B-<span class="hlt">sister</span> gene is not involved in this growth. In transgenic tobacco the Ginkgo gene has a positive role in tissue growth and confirms its importance in ovule/seed development. This study suggests that B-<span class="hlt">sister</span> genes have a main function in ovule/seed development and a subsidiary role in the formation of fleshy fruit-like structures when the latter have an ovular origin, as occurs in Ginkgo. Thus, the 'fruit function' of B-<span class="hlt">sister</span> genes is quite old, already being present in Gymnosperms as ancient as Ginkgoales, and is also present in Angiosperms where a B-<span class="hlt">sister</span> gene has been shown to be involved in the formation of the Arabidopsis fruit.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70031137','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70031137"><span>Geodetic observations and modeling of magmatic inflation at the Three <span class="hlt">Sisters</span> volcanic center, central Oregon Cascade Range, USA</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Dzurisin, Daniel; Lisowski, Michael; Wicks, Charles W.; Poland, Michael P.; Endo, Elliot T.</p> <p>2006-01-01</p> <p>Tumescence at the Three <span class="hlt">Sisters</span> volcanic center began sometime between summer 1996 and summer 1998 and was discovered in April 2001 using interferometric synthetic aperture radar (InSAR). Swelling is centered about 5 km west of the summit of South <span class="hlt">Sister</span>, a composite basaltic-andesite to rhyolite volcano that last erupted between 2200 and 2000 yr ago, and it affects an area ∼20 km in diameter within the Three <span class="hlt">Sisters</span> Wilderness. Yearly InSAR observations show that the average maximum displacement rate was 3–5 cm/yr through summer 2001, and the velocity of a continuous GPS station within the deforming area was essentially constant from June 2001 to June 2004. The background level of seismic activity has been low, suggesting that temperatures in the source region are high enough or the strain rate has been low enough to favor plastic deformation over brittle failure. A swarm of about 300 small earthquakes (Mmax = 1.9) in the northeast quadrant of the deforming area on March 23–26, 2004, was the first notable seismicity in the area for at least two decades. The U.S. Geological Survey (USGS) established tilt-leveling and EDM networks at South <span class="hlt">Sister</span> in 1985–1986, resurveyed them in 2001, the latter with GPS, and extended them to cover more of the deforming area. The 2001 tilt-leveling results are consistent with the inference drawn from InSAR that the current deformation episode did not start before 1996, i.e., the amount of deformation during 1995–2001 from InSAR fully accounts for the net tilt at South <span class="hlt">Sister</span> during 1985–2001 from tilt-leveling. Subsequent InSAR, GPS, and leveling observations constrain the source location, geometry, and inflation rate as a function of time. A best-fit source model derived from simultaneous inversion of all three datasets is a dipping sill located 6.5 ± 2.5 km below the surface with a volume increase of 5.0 × 106 ± 1.5 × 106m3/yr (95% confidence limits). The most likely cause of tumescence is a pulse of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19089666','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19089666"><span>Umbilical metastasis or <span class="hlt">Sister</span> Mary Joseph's nodule as a very early sign of an occult cecal adenocarcinoma.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Salemis, Nikolaos S</p> <p>2007-01-01</p> <p>Umbilical metastasis (<span class="hlt">Sister</span> Mary Joseph's nodule) is a rare occurrence and indicates, in most of the patients, an advanced intraabdominal malignancy. It may be the first sign of an underlying adenocarcinoma, originating mainly from the gastrointestinal or genitourinary tract. An extremely rare case of a <span class="hlt">Sister</span> Mary Joseph's nodule is described herein, where the metastatic umbilical nodule was the first sign of a cecal adenocarcinoma and became evident 8 months before the onset of the disease. Diagnostic evaluation and surgical management are discussed along with a review of the literature. This case is presented in order to emphasize the need for thorough investigation of any umbilical lesion especially in elderly patients.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29093367','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29093367"><span>[Novel Anticancer Strategy Targeting Switch Mechanisms in Two Types of Cell <span class="hlt">Death</span>: Necrosis and Apoptosis].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sato, Akira</p> <p>2017-01-01</p> <p> Two types of cell <span class="hlt">death</span>, necrosis and apoptosis, are defined in terms of cell <span class="hlt">death</span> morphological features. We have been studying the mechanisms by which cell <span class="hlt">death</span> processes are switched during the treatment of mouse tumor FM3A with anticancer, 5-fluoro-2'-deoxyuridine (FUdR): it induces original clone F28-7 to necrosis, but its sub-clone F28-7-A to apoptosis. We identified several such switch regulators of cell <span class="hlt">death</span>: heat shock protein 90 (HSP90), lamin-B1, cytokeratin-19, and activating transcription factor 3 (ATF3), by using transcriptomic, proteomic analyses and siRNA screening. For example, the inhibition of HSP90 by its inhibitor geldanamycin in F28-7 caused a shift from necrosis to apoptosis. We also observed that the knockdown of lamin-B1, cytokeratin-19, or ATF3 expression in F28-7 resulted in a shift from necrosis to apoptosis. Recently, we used microRNA (miRNA, miR) microarray analyses to investigate the miRNA expression profiles in these <span class="hlt">sister</span> cells. The miR-351 and miR-743a were expressed at higher levels in F28-7-A than in F28-7. Higher expression of miR-351 or miR-743a in F28-7, induced by transfecting the miR mimics, resulted in a switch of cell <span class="hlt">death</span> mode: necrosis to apoptosis. Furthermore, transfection of an miR-351 inhibitor into F28-7-A resulted in morphological changes, and mode of cell <span class="hlt">death</span> from apoptosis to necrosis. These findings suggest that the identified cell <span class="hlt">death</span> regulators may have key roles in switching cell <span class="hlt">death</span> mode. Possible mechanisms involving cell <span class="hlt">death</span> regulators in the switch of necrosis or apoptosis are discussed. We propose a novel anticancer strategy targeting the switch regulators of necrosis or apoptosis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=zara&id=EJ1088123','ERIC'); return false;" href="https://eric.ed.gov/?q=zara&id=EJ1088123"><span>Living with a Brother Who Has an Autism Spectrum Disorder: A <span class="hlt">Sister</span>'s Perspective</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Connell, Zara O.; Halloran, Maeve O.; Doody, Owen</p> <p>2016-01-01</p> <p>People with Autism Spectrum Disorder (ASD) are born into families and influence family functioning both positively and negatively. One of the most enduring relationships a person with ASD will have is their relationship with a brother or <span class="hlt">sister</span>. Services for people with ASD should provide effective support to families, which include brothers,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4080519','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4080519"><span>CpG Sites Associated with Cigarette Smoking: Analysis of Epigenome-Wide Data from the <span class="hlt">Sister</span> Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Harlid, Sophia; Xu, Zongli; Panduri, Vijayalakshmi; Sandler, Dale P.</p> <p>2014-01-01</p> <p>Background: Smoking increases the risk of many diseases, and it is also <span class="hlt">linked</span> to blood DNA methylation changes that may be important in disease etiology. Objectives: We sought to identify novel CpG sites associated with cigarette smoking. Methods: We used two epigenome-wide data sets from the <span class="hlt">Sister</span> Study to identify and confirm CpG sites associated with smoking. One included 908 women with methylation measurements at 27,578 CpG sites using the HumanMethylation27 BeadChip; the other included 200 women with methylation measurements for 473,844 CpG sites using the HumanMethylation450 BeadChip. Significant CpGs from the second data set that were not included in the 27K assay were validated by pyrosequencing in a subset of 476 samples from the first data set. Results: Our study successfully confirmed smoking associations for 9 previously established CpGs and identified 2 potentially novel CpGs: cg26764244 in GNG12 (p = 9.0 × 10–10) and cg22335340 in PTPN6 (p = 2.9 × 10–05). We also found strong evidence of an association between smoking status and cg02657160 in CPOX (p = 7.3 × 10–7), which has not been previously reported. All 12 CpGs were undermethylated in current smokers and showed an increasing percentage of methylation in former and never-smokers. Conclusions: We identified 2 potentially novel smoking related CpG sites, and provided independent replication of 10 previously reported CpGs sites related to smoking, one of which is situated in the gene CPOX. The corresponding enzyme is involved in heme biosynthesis, and smoking is known to increase heme production. Our study extends the evidence base for smoking-related changes in DNA methylation. Citation: Harlid S, Xu Z, Panduri V, Sandler DP, Taylor JA. 2014. CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the <span class="hlt">Sister</span> Study. Environ Health Perspect 122:673–678; http://dx.doi.org/10.1289/ehp.1307480 PMID:24704585</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.loc.gov/pictures/collection/hh/item/tn0124.photos.154039p/','SCIGOV-HHH'); return false;" href="https://www.loc.gov/pictures/collection/hh/item/tn0124.photos.154039p/"><span>10. Photocopy of photograph showing the three Walker <span class="hlt">sisters</span> ginning ...</span></a></p> <p><a target="_blank" href="http://www.loc.gov/pictures/collection/hh/">Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey</a></p> <p></p> <p></p> <p>10. Photocopy of photograph showing the three Walker <span class="hlt">sisters</span> ginning cotton. Misses Hettie, Martha and Louisa are from left to right. The original photograph was taken on May 21, 1936 by Edouard E. Exline and is one of five photographs in the album, 'A Sketch of Mountain Life: Great Smoky Mountains National Park', compiled by Edouard E. Exline and C.S. Grossman. The album is on file at the Great Smoky Mountains National Park; the photograph number is III-A-HSE-9642. - Walker Family Farm (General views), Gatlinburg, Sevier County, TN</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3184230','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3184230"><span>Clopidogrel discontinuation after acute coronary syndromes: frequency, predictors and associations with <span class="hlt">death</span> and myocardial infarction—a hospital registry-primary care <span class="hlt">linked</span> cohort (MINAP–GPRD)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Boggon, Rachael; van Staa, Tjeerd P.; Timmis, Adam; Hemingway, Harry; Ray, Kausik K.; Begg, Alan; Emmas, Cathy; Fox, Keith A.A.</p> <p>2011-01-01</p> <p>Aims Adherence to evidence-based treatments and its consequences after acute myocardial infarction (MI) are poorly defined. We examined the extent to which clopidogrel treatment initiated in hospital is continued in primary care; the factors predictive of clopidogrel discontinuation and the hazard of <span class="hlt">death</span> or recurrent MI. Methods and results We <span class="hlt">linked</span> the Myocardial Ischaemia National Audit Project registry and the General Practice Research Database to examine adherence to clopidogrel in primary care among patients discharged from hospital after MI (2003–2009). Hospital Episode Statistics and national mortality data were <span class="hlt">linked</span>, documenting all-cause mortality and non-fatal MI. Of the 7543 <span class="hlt">linked</span> patients, 4650 were prescribed clopidogrel in primary care within 3 months of discharge. The adjusted odds of still being prescribed clopidogrel at 12 months were similar following non-ST-elevation myocardial infarction (NSTEMI) 53% (95% CI, 51–55) and ST-elevation myocardial infarction (STEMI) 54% (95% CI, 52–56), but contrast with statins: NSTEMI 84% (95% CI, 82–85) and STEMI 89% (95% CI, 87–90). Discontinuation within 12 months was more frequent in older patients [>80 vs. 40–49 years, adjusted hazard ratio (HR) 1.50 (95% CI, 1.15–1.94)] and with bleeding events [HR 1.34 (95% CI, 1.03–1.73)]. 18.15 patients per 100 person-years (95% CI, 16.83–19.58) died or experienced non-fatal MI in the first year following discharge. In patients who discontinued clopidogrel within 12 months, the adjusted HR for <span class="hlt">death</span> or non-fatal MI was 1.45 (95% CI, 1.22–1.73) compared with untreated patients, and 2.62 (95% CI, 2.17–3.17) compared with patients persisting with clopidogrel treatment. Conclusion This is the first study to use <span class="hlt">linked</span> registries to determine persistence of clopidogrel treatment after MI in primary care. It demonstrates that discontinuation is common and associated with adverse outcomes. PMID:21875855</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28327810','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28327810"><span>Spatial-temporal analysis of dengue <span class="hlt">deaths</span>: identifying social vulnerabilities.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Silva, Maria do Socorro da; Branco, Maria Dos Remédios Freitas Carvalho; Aquino, José; Queiroz, Rejane Christine de Sousa; Bani, Emanuele; Moreira, Emnielle Pinto Borges; Medeiros, Maria Nilza Lima; Rodrigues, Zulimar Márita Ribeiro</p> <p>2017-01-01</p> <p>Currently, dengue fever, chikungunya fever, and zika virus represent serious public health issues in Brazil, despite efforts to control the vector, the Aedes aegypti mosquito. This was a descriptive and ecological study of dengue <span class="hlt">deaths</span> occurring from 2002 to 2013 in São Luis, Maranhão, Brazil. Geoprocessing software was used to draw maps, <span class="hlt">linking</span> the geo-referenced <span class="hlt">deaths</span> with urban/social data at census tract level. There were 74 <span class="hlt">deaths</span>, concentrated in areas of social vulnerability. The use of geo-technology tools pointed to a concentration of dengue <span class="hlt">deaths</span> in specific intra-urban areas.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=nun+AND+study&pg=3&id=EJ1078896','ERIC'); return false;" href="https://eric.ed.gov/?q=nun+AND+study&pg=3&id=EJ1078896"><span>Teaching <span class="hlt">Sisters</span> and Transnational Networks: Recruitment and Education Expansion in the Long Nineteenth Century</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Raftery, Deirdre</p> <p>2015-01-01</p> <p>This article examines the management of the education enterprise of teaching <span class="hlt">Sisters</span>, with reference to their transnational networking. The article suggests that orders of women religious were the first all-female transnational networks, engaged constantly in work that was characterised by "movement, ebb and circulation". The mobility of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18028149','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18028149"><span>'Angels in nursing': images of nursing <span class="hlt">sisters</span> in a Lutheran context in the nineteenth and twentieth centuries.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Malchau, Susanne</p> <p>2007-12-01</p> <p>This article examines Catholic nursing orders in Denmark. In 1849, 300 years after the Reformation, freedom of worship was introduced in Lutheran Denmark. In 1856 the first Catholic nursing order in modern times settled in the country. Others followed, and in 1940 the nursing orders owned 17 general hospitals and had a share of 10% of the hospital beds in Denmark. The purpose of this article is to identify images in the public media text of these Catholic nursing orders in Denmark from 1856 to the present, and to deconstruct the existing angel image the nuns and <span class="hlt">sisters</span> in nursing have obtained. The assumption is that the public image is an important indicator of how a profession is valued in society. Six images - three positive and three negative - are identified, and it is demonstrated that these images were closely connected to the nursing <span class="hlt">sisters</span>' professional activities and confessional affiliation. Until the 1950s the image of nursing <span class="hlt">sisters</span> as representing a counterculture in Lutheran Denmark persisted. This image was succeeded by one of professional nurses of high standards. The shift was caused by increased secularisation and the renewal of religious life, as a result of the Second Vatican Council in the 1960s.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16309949','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16309949"><span>Evaluation of genotoxic effects of Apitol (cymiazole hydrochloride) in vitro by measurement of <span class="hlt">sister</span> chromatid exchange.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stanimirovic, Zoran; Stevanovic, Jevrosima; Jovanovic, Slobodan; Andjelkovic, Marko</p> <p>2005-12-30</p> <p>Apitol, with cymiazole hydrochloride as the active ingredient, is used in bee-keeping against the ectoparasitic mite Varroa destructor. The preparation was evaluated for genotoxicity in cultured human peripheral blood lymphocytes. <span class="hlt">Sister</span> chromatid exchange, the mitotic index and the cell proliferation index were determined for three experimental concentrations of Apitol (0.001, 0.01 and 0.1 mg/ml). All concentrations significantly (p < 0.001) increased the mitotic index (MI = 7.35+/-0.18%, 8.31+/-0.20% and 12.33+/-0.25%, respectively), the proliferative index (PI = 1.83+/-0.01, 1.84+/-0.01 and 1.88+/-0.02, respectively) and the frequency of <span class="hlt">sister</span> chromatid exchange (SCE = 8.19+/-1.81, 8.78+/-1.80 and 13.46+/-1.88, respectively), suggesting that cymiazole hydrochloride has genotoxic potential.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/8917724','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/8917724"><span>Transglutaminase induction by various cell <span class="hlt">death</span> and apoptosis pathways.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fesus, L; Madi, A; Balajthy, Z; Nemes, Z; Szondy, Z</p> <p>1996-10-31</p> <p>Clarification of the molecular details of forms of natural cell <span class="hlt">death</span>, including apoptosis, has become one of the most challenging issues of contemporary biomedical sciences. One of the effector elements of various cell <span class="hlt">death</span> pathways is the covalent cross-<span class="hlt">linking</span> of cellular proteins by transglutaminases. This review will discuss the accumulating data related to the induction and regulation of these enzymes, particularly of tissue type transglutaminase, in the molecular program of cell <span class="hlt">death</span>. A wide range of signalling pathways can lead to the parallel induction of apoptosis and transglutaminase, providing a handle for better understanding the exact molecular interactions responsible for the mechanism of regulated cell <span class="hlt">death</span>.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_11 --> <div id="page_12" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="221"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16900931','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16900931"><span>Unusual phenotypic expression of an XLRS1 mutation in X-<span class="hlt">linked</span> juvenile retinoschisis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dodds, Jodi A; Srivastava, Anand K; Holden, Kenton R</p> <p>2006-04-01</p> <p>X-<span class="hlt">linked</span> juvenile retinoschisis is a rare progressive vitreoretinal degenerative process that appears in early childhood, results in decreased visual acuity and blindness (if severe), and is caused by various mutations within the XLRS1 gene at Xp22.2. We report an affected family of Western European ancestry with X-<span class="hlt">linked</span> juvenile retinoschisis. The family was found to carry a 304C-->T substitution in exon 4 of the XLRS1 gene, resulting in an Arg102Trp amino acid substitution. Two of the four available clinical cases in this family were found to carry the mutation. All available mothers of affected males were found to be unaffected carriers of the mutation, a typical feature of X-<span class="hlt">linked</span> diseases. Two new female carriers, <span class="hlt">sisters</span> of affected males, were identified and counseled accordingly. Questionnaires on visual functioning were given to the affected family members to examine the psychologic and sociologic impact of X-<span class="hlt">linked</span> juvenile retinoschisis, which documented an associated stigma even when affected with a "mild" phenotype.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Chess&pg=4&id=EJ939604','ERIC'); return false;" href="https://eric.ed.gov/?q=Chess&pg=4&id=EJ939604"><span>Does High-Level Intellectual Performance Depend on Practice Alone? Debunking the Polgar <span class="hlt">Sisters</span> Case</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Howard, Robert W.</p> <p>2011-01-01</p> <p>The famous Polgar <span class="hlt">sisters</span> started chess very young, undertook extensive study, and two became grandmasters. This case often is cited as decisive evidence that practice alone is key in development of expertise, that innate talent is unimportant or non-existent, and that almost anyone can become a grandmaster. But on close examination these claims…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27801743','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27801743"><span>99mTc-DMSA Uptake in a <span class="hlt">Sister</span> Mary Joseph's Nodule From Ovarian Cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Naddaf, Sleiman; Azzumeea, Fahad; Fahad Alzayed, Mohammed</p> <p>2016-12-01</p> <p>A 50-year-old woman with ovarian cancer underwent Tc-DMSA scan to evaluate the functional status of the right hydronephrotic kidney. The images incidentally revealed a well-defined focus of mild radiotracer uptake at the midanterior abdominal wall, which correlated with a metastatic <span class="hlt">Sister</span> Mary Joseph's nodule seen on CT performed a week earlier.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=family+AND+affects+AND+culture&pg=7&id=EJ903417','ERIC'); return false;" href="https://eric.ed.gov/?q=family+AND+affects+AND+culture&pg=7&id=EJ903417"><span>Transitioning from Doctoral Study to the Academy: Theorizing "Trenzas" of Identity for Latina <span class="hlt">Sister</span> Scholars</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Espino, Michelle M.; Munoz, Susana M.; Kiyama, Judy Marquez</p> <p>2010-01-01</p> <p>This article focuses on multiple truths pertaining to doctoral education as expressed by three Latina doctoral recipients. These scholars successfully navigated various educational processes with the support of one another, their families, faculty, and their chosen discipline. The authors, as <span class="hlt">sister</span> scholars, retell their educational journeys…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=family+AND+role&pg=3&id=EJ997719','ERIC'); return false;" href="https://eric.ed.gov/?q=family+AND+role&pg=3&id=EJ997719"><span>A Tale of Three <span class="hlt">Sisters</span>: Language Ideologies, Identities, and Negotiations in a Bilingual, Transnational Family</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>King, Kendall A.</p> <p>2013-01-01</p> <p>This longitudinal case study investigated how linguistic identity was constructed, constrained, and performed by three <span class="hlt">sisters</span>, aged 1, 12, and 17, within one bilingual, transnational Ecuadorian-U.S. family. Data were collected over 14 months through weekly home visits that included participant observation, informal interviews, and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25016773','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25016773"><span>[Sense of coherence and ways of coping in the relationship with brother or <span class="hlt">sister</span> in healthy siblings of mentally ill persons].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Osuchowska-Kościjańska, Anna; Charzyńska, Katarzyna; Chadzyńska, Małgorzata; Drozdzyńska, Anna; Kasperek-Zimowska, Beata; Bednarek, Agata; Sawicka, Maryla</p> <p>2014-01-01</p> <p>The aim of the present study was to investigate sense of coherence in healthy siblings of persons suffering from schizophrenia as well as their ways of coping in the relationship with ill brother or <span class="hlt">sister</span>. 40 healthy brothers and <span class="hlt">sisters</span> of persons with ICD- 10 diagnosis of F20 to F29 participated in the present study. Orientation to Life Scale (SOC- 29) was used to assess sense of coherence and Ways of Coping with Stress questionnaire (SRSS) was used to examine stress coping strategies. Mean global score of siblings of persons with schizophrenia was 111 points. Subjects used coping strategies focused on problem significantly more often than those focused on emotions. Therapeutic work with healthy siblings should focus on strengthening sense of personal competence, development of personal resources and different ways of coping with stress, investigation of emotions that healthy siblings experience in the relationship with ill brother or <span class="hlt">sister</span> as well as supporting the process of accepting changes in the relationship with the ill sibling.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10761928','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10761928"><span>Establishing biorientation occurs with precocious separation of the <span class="hlt">sister</span> kinetochores, but not the arms, in the early spindle of budding yeast.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Goshima, G; Yanagida, M</p> <p>2000-03-17</p> <p><span class="hlt">Sister</span> kinetochores are bioriented toward the spindle poles in higher eukaryotic prometaphase before chromosome segregation. We show that, in budding yeast, the <span class="hlt">sister</span> kinetochores are separated in the very early spindle, while the <span class="hlt">sister</span> arms remain associated. Biorientation of the separated kinetochores is achieved already after replication. Mtw1p, a homolog of fission yeast Mis12 required for biorientation, locates at the centromeres in an Ndc10p-dependent manner. Mtw1p and the sequences 1.8 and 3.8 kb from CEN3 and CEN15, respectively, behave like the precociously separated kinetochores, whereas the sequences 23 and 35 kb distant from CEN3 and CEN5 previously used as the centromere markers behave like a part of the arm. Mtw1p and Ndc10p are identically located except for additional spindle localization of Ndc10p. A model explaining small centromeres and early spindle formation in budding yeast is proposed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16054398','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16054398"><span>The phylogenetic relationships among non-diplomystid catfishes as inferred from mitochondrial cytochrome b sequences; the search for the ictalurid <span class="hlt">sister</span> taxon (Otophysi: Siluriformes).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hardman, Michael</p> <p>2005-12-01</p> <p>The relationships among families of catfishes are poorly understood and have yet to be the subject of a comprehensive investigation with molecular data. Existing phylogenetic hypotheses are based on morphological data and incompletely resolved. This study analyzed complete sequences of mitochondrial gene cytochrome b for 170 species from 29 of 33 extant families, and focused on the relationships of Ictaluridae to other catfishes. In addition to previous phylogenetic studies, the fossil record, paleogeography, biogeography, and distribution of extant catfish families collectively suggest the location (if extant) of the ictalurid <span class="hlt">sister</span> taxon to be Northern or Eastern Asia. Of the extant catfishes currently native to this area and included in this analysis, parsimony and Bayesian likelihood analyses recovered Cranoglanis bouderius as the most proximal <span class="hlt">sister</span> taxon of Ictaluridae. Seemingly, ictalurids and cranoglanidids represent another biogeographic component <span class="hlt">linking</span> freshwater fishes of North America and eastern Asia, e.g., catostomids and paddlefishes. The results coupled with present-day catfish distributions and inferences from the fossil record collectively suggest the ancestor of Ictaluridae to have invaded freshwaters of North America at the close of the Cretaceous through northeastern Asia and northwestern North America. Other superfamilial nodes supported the results of previous phylogenetic studies of narrower taxonomic scope. Several novel relationships were recovered (including a clade composed of Pimelodidae, Pseudopimelodidae, and Heptapteridae) and these along with sources of systematic error are discussed. A broad sampling of Bagridae permitted an examination of intergeneric relationships within this family and in light of recent morphological and molecular studies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5587752','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5587752"><span>FANCJ helicase controls the balance between short- and long-tract gene conversions between <span class="hlt">sister</span> chromatids</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nath, Sarmi; Somyajit, Kumar; Mishra, Anup; Scully, Ralph</p> <p>2017-01-01</p> <p>Abstract The FANCJ DNA helicase is <span class="hlt">linked</span> to hereditary breast and ovarian cancers as well as bone marrow failure disorder Fanconi anemia (FA). Although FANCJ has been implicated in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR), the molecular mechanism underlying the tumor suppressor functions of FANCJ remains obscure. Here, we demonstrate that FANCJ deficient human and hamster cells exhibit reduction in the overall gene conversions in response to a site-specific chromosomal DSB induced by I-SceI endonuclease. Strikingly, the gene conversion events were biased in favour of long-tract gene conversions in FANCJ depleted cells. The fine regulation of short- (STGC) and long-tract gene conversions (LTGC) by FANCJ was dependent on its interaction with BRCA1 tumor suppressor. Notably, helicase activity of FANCJ was essential for controlling the overall HR and in terminating the extended repair synthesis during <span class="hlt">sister</span> chromatid recombination (SCR). Moreover, cells expressing FANCJ pathological mutants exhibited defective SCR with an increased frequency of LTGC. These data unravel the novel function of FANCJ helicase in regulating SCR and SCR associated gene amplification/duplications and imply that these functions of FANCJ are crucial for the genome maintenance and tumor suppression. PMID:28911102</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4590742','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4590742"><span>Long-Term Air Pollution Exposure and Blood Pressure in the <span class="hlt">Sister</span> Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Chan, Stephanie H.; Van Hee, Victor C.; Bergen, Silas; Szpiro, Adam A.; DeRoo, Lisa A.; London, Stephanie J.; Marshall, Julian D.; Sandler, Dale P.</p> <p>2015-01-01</p> <p>Background Exposure to air pollution has been consistently associated with cardiovascular morbidity and mortality, but mechanisms remain uncertain. Associations with blood pressure (BP) may help to explain the cardiovascular effects of air pollution. Objective We examined the cross-sectional relationship between long-term (annual average) residential air pollution exposure and BP in the National Institute of Environmental Health Sciences’ <span class="hlt">Sister</span> Study, a large U.S. cohort study investigating risk factors for breast cancer and other outcomes. Methods This analysis included 43,629 women 35–76 years of age, enrolled 2003–2009, who had a <span class="hlt">sister</span> with breast cancer. Geographic information systems contributed to satellite-based nitrogen dioxide (NO2) and fine particulate matter (≤ 2.5 μm; PM2.5) predictions at participant residences at study entry. Generalized additive models were used to examine the relationship between pollutants and measured BP at study entry, adjusting for cardiovascular disease risk factors and including thin plate splines for potential spatial confounding. Results A 10-μg/m3 increase in PM2.5 was associated with 1.4-mmHg higher systolic BP (95% CI: 0.6, 2.3; p < 0.001), 1.0-mmHg higher pulse pressure (95% CI: 0.4, 1.7; p = 0.001), 0.8-mmHg higher mean arterial pressure (95% CI: 0.2, 1.4; p = 0.01), and no significant association with diastolic BP. A 10-ppb increase in NO2 was associated with a 0.4-mmHg (95% CI: 0.2, 0.6; p < 0.001) higher pulse pressure. Conclusions Long-term PM2.5 and NO2 exposures were associated with higher blood pressure. On a population scale, such air pollution–related increases in blood pressure could, in part, account for the increases in cardiovascular disease morbidity and mortality seen in prior studies. Citation Chan SH, Van Hee VC, Bergen S, Szpiro AA, DeRoo LA, London SJ, Marshall JD, Kaufman JD, Sandler DP. 2015. Long-term air pollution exposure and blood pressure in the <span class="hlt">Sister</span> Study. Environ Health</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=sister+AND+cities&id=EJ927867','ERIC'); return false;" href="https://eric.ed.gov/?q=sister+AND+cities&id=EJ927867"><span>Mentoring in Schools: An Impact Study of Big Brothers Big <span class="hlt">Sisters</span> School-Based Mentoring</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Herrera, Carla; Grossman, Jean Baldwin; Kauh, Tina J.; McMaken, Jennifer</p> <p>2011-01-01</p> <p>This random assignment impact study of Big Brothers Big <span class="hlt">Sisters</span> School-Based Mentoring involved 1,139 9- to 16-year-old students in 10 cities nationwide. Youth were randomly assigned to either a treatment group (receiving mentoring) or a control group (receiving no mentoring) and were followed for 1.5 school years. At the end of the first school…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24796997','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24796997"><span>Limited genomic consequences of mixed mating in the recently derived <span class="hlt">sister</span> species pair, Collinsia concolor and Collinsia parryi.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Salcedo, A; Kalisz, S; Wright, S I</p> <p>2014-07-01</p> <p>Highly selfing species often show reduced effective population sizes and reduced selection efficacy. Whether mixed mating species, which produce both self and outcross progeny, show similar patterns of diversity and selection remains less clear. Examination of patterns of molecular evolution and levels of diversity in species with mixed mating systems can be particularly useful for investigating the relative importance of <span class="hlt">linked</span> selection and demographic effects on diversity and the efficacy of selection, as the effects of <span class="hlt">linked</span> selection should be minimal in mixed mating populations, although severe bottlenecks tied to founder events could still be frequent. To begin to address this gap, we assembled and analysed the transcriptomes of individuals from a recently diverged mixed mating <span class="hlt">sister</span> species pair in the self-compatible genus, Collinsia. The de novo assembly of 52 and 37 Mbp C. concolor and C. parryi transcriptomes resulted in ~40 000 and ~55 000 contigs, respectively, both with an average contig size ~945. We observed a high ratio of shared polymorphisms to fixed differences in the species pair and minimal differences between species in the ratio of synonymous to replacement substitutions or codon usage bias implying comparable effective population sizes throughout species divergence. Our results suggest that differences in effective population size and selection efficacy in mixed mating taxa shortly after their divergence may be minimal and are likely influenced by fluctuating mating systems and population sizes. © 2014 The Authors. Journal of Evolutionary Biology © 2014 European Society For Evolutionary Biology.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/391300-induction-sister-chromatid-exchange-presence-gadolinium-dtpa-its-reduction-dimethyl-sulfoxide','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/391300-induction-sister-chromatid-exchange-presence-gadolinium-dtpa-its-reduction-dimethyl-sulfoxide"><span>Induction of <span class="hlt">sister</span> chromatid exchange in the presence of gadolinium-DTPA and its reduction by dimethyl sulfoxide</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Yamazaki, Etsuo; Fukuda, Hozumi; Shibuya, Hitoshi</p> <p></p> <p>The authors investigate the frequency of <span class="hlt">sister</span> chromatid exchange (SCE) after the addition of gadolinium (Gd)-DTPA to venous blood samples. Venous blood was obtained from nonsmokers. Samples were incubated with Gd-DTPA alone or in combination with mitomycin C, cytarabine, and dimethyl sulfoxide (DMSO), and then evaluated for SCEs. The frequency of SCE increased with the concentration of Gd-DTPA and as each chemotherapeutic agent was added. <span class="hlt">Sister</span> chromatid exchange frequencies were lower when the blood was treated with a combination of Gd-DTPA and DMSO compared with Gd-DTPA alone. The increase in frequency of SCE seen after the addition of Gd-DTPA wasmore » decreased by the addition of DMSO, indicating the production of hydroxyl radicals. The effect likely is dissociation-related. 14 refs., 6 tabs.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20528137','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20528137"><span>Is beauty skin deep? The impact of "beautiful attributes" on life opportunities and interpersonal relationships: a tale of two <span class="hlt">sisters</span> in South India.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ullrich, Helen E</p> <p>2010-01-01</p> <p>The focus of this article is the impact of culturally perceived beauty and its attributes on identity formation and interpersonal relationships. In South India skin color is perhaps the most important aspect of beauty. Socialization starts from infancy, as people talk openly about a child's skin color and other "beautiful attributes" from the time of a child's birth. Women with the cultural designation of beautiful are more assertive than those women designated unattractive. Moreover, the increased self-confidence associated with their beauty allows them greater leeway to shape their lives according to their own desires. I will discuss culturally relevant "beautiful attributes" and the developmental impact on two <span class="hlt">sisters</span>. The older <span class="hlt">sister</span> was regarded as beautiful while her younger <span class="hlt">sister</span> was considered less attractive. Cultural validation provides a theater for assertiveness while denigration enhances vulnerability to depression.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005AAS...206.3406B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005AAS...206.3406B"><span>Where are Sedna's <span class="hlt">Sisters</span>?</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bartlett, D. F.</p> <p>2005-05-01</p> <p>Simulations of the formation of the Oort cloud from the Kuiper Belt typically are presented as an animated scatter diagram. Here the orbit of each object appears as a point of perihelion distance q and semi-major axis a. (eg. Levison, Morbidelli, & Dones 2004). These plots show a conspicuous void, bounded by the inequalities: q < a, q > 50 AU, and a < 5000-10000 AU. Brown (2005) calls this void the ``Bermuda Triangle". The only present occupant is Sedna (q=76 AU, a=501 AU). Brown, Trujillo, & Rabinowitz , the discovers of Sedna, have challenged others to explain how Sedna got inside the triangle and to predict where similar objects might be found. Sedna could not have simply formed in its current orbit by the accumulation of smaller objects (Stern 2005). Several authors have suggested that a passing star scattered Sedna into the triangle shortly after the birth of the solar system. Here I offer an alternative which uses the very strong galactic tidal forces of the Sinusoidal potential (Bartlett 2001, 2004). In this potential, the numerator of Newton's law is replaced by GM cos(ko r) where ko = 2 π / lambdao and the 'wavelength' λ o is 425 pc. The 20 radial oscillations between the sun and the center of the Galaxy give tidal forces that are 120 times as big as generally expected. I will show how this tidal force, acting over the lifetime of the solar system, could move the perihelion of Sedna from about 40 to 76 AU. Sedna's <span class="hlt">sisters</span> are likely to have still larger q & a and to have perihelia in two specific quadrants of the ecliptic plane.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21446266','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21446266"><span>Getting SaaS-y. Why the <span class="hlt">sisters</span> of Mercy Health System opted for on-demand portfolio management.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Carter, Jay</p> <p>2011-03-01</p> <p><span class="hlt">Sisters</span> of Mercy Health System chose the SaaS model as a simpler way to plan, execute, and monitor strategic business initiatives. It also provided something that was easy to use and offered quick time to value.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19932938','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19932938"><span>Subclinical hyperthyroidism and sudden unexpected <span class="hlt">death</span> in epilepsy.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Scorza, Fulvio A; Arida, Ricardo M; Cysneiros, Roberta M; Terra, Vera C; de Albuquerque, Marly; Machado, Hélio R; Cavalheiro, Esper A</p> <p>2010-04-01</p> <p>Epilepsy is the most common serious neurological condition and sudden unexpected <span class="hlt">death</span> in epilepsy (SUDEP) is the most important direct epilepsy-related cause of <span class="hlt">death</span>. Information concerning risk factors for SUDEP is conflicting, but high seizure frequency is a potential risk factor. Additionally, potential pathomechanisms for SUDEP are unknown, but it is very probable that cardiac arrhythmias during and between seizures or transmission of epileptic activity to the heart via the autonomic nervous system potentially play a role. In parallel, several studies have shown a <span class="hlt">link</span> between hormones and epilepsy. However, exact knowledge regarding the association of thyroid hormones and epilepsy is lacking. As subclinical hyperthyroidism has been <span class="hlt">linked</span> with increased risk of cardiovascular disease, we propose in this paper that SUDEP, at least in some cases, could be related with subclinical thyroid dysfunction. (c) 2009 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/3804956','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/3804956"><span>Sibling relationships of children with autistic, mentally retarded, and nonhandicapped brothers and <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McHale, S M; Sloan, J; Simeonsson, R J</p> <p>1986-12-01</p> <p>The subjects were 90 children between 6 and 15 years of age, 30 with autistic, 30 with mentally retarded, and 30 with nonhandicapped brothers or <span class="hlt">sisters</span>. The children were questioned about their sibling relationships in an open-ended interview, and, in the case of children with handicapped siblings, they also responded to questions about particular problems they faced in regard to their brothers or <span class="hlt">sisters</span>. In addition, mothers filled out a behavior rating scale in which they described the positive and negative aspects of their children's behavior toward the sibling. In general, children and mothers rated the sibling relationships positively. Group comparisons indicated that children with autistic and mentally retarded siblings did not differ on any self-report measures. Children with nonhandicapped siblings reported that their family relations were slightly more cohesive but otherwise did not differ in terms of their self-reports from children with handicapped siblings. Mothers of nonhandicapped children, however, rated the sibling relationships more negatively than did mothers of handicapped children. Further analyses revealed that status variables (age, gender, family size) were not as highly correlated with the quality of sibling relationships with handicapped children as were specific problem areas (e.g., perceptions of parental favoritism, coping ability, concerns about the handicapped child's future).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1777709','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1777709"><span>Adjustment to the <span class="hlt">death</span> of a sibling.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pettle Michael, S A; Lansdown, R G</p> <p>1986-01-01</p> <p>Despite the recent increase in interest in terminally ill children and their families and the post <span class="hlt">death</span> adjustment of parents, there has been little research examining the adjustment and self concept of surviving siblings in such families. This paper discusses the results of a preliminary descriptive study of 28 children (from 14 families) whose brother or <span class="hlt">sister</span> had died of cancer between 18 and 30 months previously. Behaviour checklists were completed by parents and teachers and self concept scales administered to the children. A lengthy semistructured interview was carried out, and measures of parental adjustment were gathered. A high percentage of children were found to be exhibiting emotional or behavioural difficulties, or both, and the results indicated that low self esteem was common. Parental and child adjustment were not found to be related inter se, nor did they seem to relate to the child's self esteem. Thus for many children the loss of a sibling might cause long term distress. Further, many children who did not manifest overt difficulties perceived themselves unfavourably in comparison with either their ideal or their dead sibling. PMID:3963872</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22701929','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22701929"><span>Under the shadow of maternity: birth, <span class="hlt">death</span> and puerperal insanity in Victorian Britain.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Marland, Hilary</p> <p>2012-03-01</p> <p><span class="hlt">Death</span> and fear of <span class="hlt">death</span> in cases of puerperal insanity can be <span class="hlt">linked</span> to a much broader set of anxieties surrounding childbirth in Victorian Britain. Compared with other forms of mental affliction, puerperal insanity was known for its good prognosis, with many women recovering over the course of several months. Even so, a significant number of <span class="hlt">deaths</span> were associated with the disorder, and a large proportion of sufferers struggled with urges to destroy their infants and themselves. The disorder evoked powerful delusions concerning <span class="hlt">death</span>, with patients expressing intimations of mortality and longing for <span class="hlt">death</span>.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_12 --> <div id="page_13" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="241"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4035876','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4035876"><span>Lung Cancer <span class="hlt">Deaths</span> Among American Indians and Alaska Natives, 1990–2009</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Plescia, Marcus; Henley, Sarah Jane; Pate, Anne; Underwood, J. Michael; Rhodes, Kris</p> <p>2014-01-01</p> <p>Objectives. We examined regional differences in lung cancer among American Indians/Alaska Natives (AI/ANs) using <span class="hlt">linked</span> data sets to minimize racial misclassification. Methods. On the basis of federal lung cancer incidence data for 1999 to 2009 and <span class="hlt">deaths</span> for 1990 to 2009 <span class="hlt">linked</span> with Indian Health Service (IHS) registration records, we calculated age-adjusted incidence and <span class="hlt">death</span> rates for non-Hispanic AI/AN and White persons by IHS region, focusing on Contract Health Service Delivery Area (CHSDA) counties. We correlated <span class="hlt">death</span> rates with cigarette smoking prevalence and calculated mortality-to-incidence ratios. Results. Lung cancer <span class="hlt">death</span> rates among AI/AN persons in CHSDA counties varied across IHS regions, from 94.0 per 100 000 in the Northern Plains to 15.2 in the Southwest, reflecting the strong correlation between smoking and lung cancer. For every 100 lung cancers diagnosed, there were 6 more <span class="hlt">deaths</span> among AI/AN persons than among White persons. Lung cancer <span class="hlt">death</span> rates began to decline in 1997 among AI/AN men and are still increasing among AI/AN women. Conclusions. Comparison of regional lung cancer <span class="hlt">death</span> rates between AI/AN and White populations indicates disparities in tobacco control and prevention interventions. Efforts should be made to ensure that AI/AN persons receive equal benefit from current and emerging lung cancer prevention and control interventions. PMID:24754613</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21215191','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21215191"><span>[Long-term follow-up of isolated-growth hormone deficiency typeIA: the clinical analysis of 2-<span class="hlt">sister</span> cases].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chang, Guo-ying; Dong, Zhi-ya; Wang, Wei; Wang, De-fen</p> <p>2010-12-01</p> <p>To elucidate the curative and adverse effect of recombinant human growth hormone (rhGH) in 2 patients with isolated-growth hormone deficiency type IA (IGHDIA), to track sexual development and pregnancy, and reassess the quality of life in the adulthood. The authors summarized the data of 2-<span class="hlt">sister</span> cases with IGHDIA; followed up for assessment of height, weight, blood pressure and sexual development; detected fasting blood lipids, glucose, insulin, insulin growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3); made an investigation of education and occupation, and so on. After 6.2 and 7.3 years treatment with rhGH, the two <span class="hlt">sisters</span> had considerably improved height from -7.8 SDS, -8.8 SDS to -2.6 SDS and -1.3 SDS respectively. No evident side effect was observed. They had normal sexual development and pregnancy. The levels of IGF-1 and IGFBP-3 were still low, in the elder <span class="hlt">sister</span> they were 46.6 µg/L, 2460 µg/L, and in the younger 52.4 µg/L, 2430 µg/L. No hyperlipidemia, diabetes or obesity occurred. Long term therapy with rhGH may improve final adult height of individuals with IGHDIA. They can have normal sexual development and pregnancy. Metabolic syndrome did not occur during the follow-up period.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23822156','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23822156"><span>Applications of social network media in medicolegal <span class="hlt">death</span> investigation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hookano, Ryan; Knight, Laura D; Brunelli, Ronald A; Stoppacher, Robert</p> <p>2013-11-01</p> <p>With the increased popularity of online social networking services (SNS) such as Facebook, <span class="hlt">Linked</span>In, Twitter, and Google+, we propose that a wealth of new resources is available for medicolegal <span class="hlt">death</span> investigation. Recognizing this potential, we identified cases in which social media had been useful in the past in our office and asked our investigative staff to consider using social media in current cases. These cases provided illustrative examples for this primer regarding how information from SNS was used in <span class="hlt">death</span> investigations in our office. Information gleaned from online social media aided in establishing preliminary identification of a decedent, locating next-of-kin, investigating the circumstances of <span class="hlt">death</span> as relevant to the manner of <span class="hlt">death</span>, corroborating eyewitness accounts, and providing information relevant to time of <span class="hlt">death</span>. Potential pitfalls were identified, such as shared accounts or online impostors. SNS proved useful to the medicolegal <span class="hlt">death</span> investigator and medical examiner, so long as their limitations were recognized. © 2013 American Academy of Forensic Sciences.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3806038','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3806038"><span>Design principles of the sparse coding network and the role of “<span class="hlt">sister</span> cells” in the olfactory system of Drosophila</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zhang, Danke; Li, Yuanqing; Wu, Si; Rasch, Malte J.</p> <p>2013-01-01</p> <p>Sensory systems face the challenge to represent sensory inputs in a way to allow easy readout of sensory information by higher brain areas. In the olfactory system of the fly drosopohila melanogaster, projection neurons (PNs) of the antennal lobe (AL) convert a dense activation of glomeruli into a sparse, high-dimensional firing pattern of Kenyon cells (KCs) in the mushroom body (MB). Here we investigate the design principles of the olfactory system of drosophila in regard to the capabilities to discriminate odor quality from the MB representation and its robustness to different types of noise. We focus on understanding the role of highly correlated homotypic projection neurons (“<span class="hlt">sister</span> cells”) found in the glomeruli of flies. These cells are coupled by gap-junctions and receive almost identical sensory inputs, but target randomly different KCs in MB. We show that <span class="hlt">sister</span> cells might play a crucial role in increasing the robustness of the MB odor representation to noise. Computationally, <span class="hlt">sister</span> cells thus might help the system to improve the generalization capabilities in face of noise without impairing the discriminability of odor quality at the same time. PMID:24167488</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol1/pdf/CFR-2010-title20-vol1-sec222-40.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol1/pdf/CFR-2010-title20-vol1-sec222-40.pdf"><span>20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or <span class="hlt">Sister</span> § 222.40 When determinations of relationship are made for parent, grandchild... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When determinations of relationship are made...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11748978','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11748978"><span><span class="hlt">Sister</span> chromatid exchange rate and alkaline comet assay scores in patients with ovarian cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Baltaci, Volkan; Kayikçioğlu, Fulya; Alpas, Idil; Zeyneloğlu, Hulusi; Haberal, Ali</p> <p>2002-01-01</p> <p><span class="hlt">Sister</span> chromatid exchange (SCE) frequencies were studied in patients with different types of ovarian malignancies and in healthy volunteers. The level of DNA damage in patients with ovarian malignancy and control subjects has also been studied by alkaline single cell gel electrophoresis (SCGE), also known as the comet assay. Peripheral blood was collected from 30 patients after histological confirmation of malignancy and 20 healthy female volunteers. The cells were evaluated according to their grade of damage. We found that the <span class="hlt">sister</span> chromatid exchange frequencies of cancer cases were significantly greater than that of controls (P < 0.001). The frequency of exchange in chromosomal groups A, B, and C, which include chromosomes 1-12, was higher than that of the other chromosomal groups in both groups. Comparison of the results of the alkaline comet assay in patient and control subjects showed a significant difference in the number of damaged cells. The frequency of limited migrated and extensive migrated cells in the women with ovarian malignancies was higher than that of control women (P < 0.001). SCE and SCGE can be used successfully to monitor DNA damage in women with ovarian cancer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=ethiopia&pg=5&id=EJ1172752','ERIC'); return false;" href="https://eric.ed.gov/?q=ethiopia&pg=5&id=EJ1172752"><span>'For Good, God, and the Empire': French Franciscan <span class="hlt">Sisters</span> in Ethiopia 1896-1937</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Guidi, Pierre</p> <p>2018-01-01</p> <p>In 1897, four French Franciscan <span class="hlt">sisters</span> arrived in Ethiopia, having been summoned there by the Capuchin missionaries. In 1925, they ran an orphanage, a dispensary, a leper colony and 10 schools with 350 girl students. The students were freed slaves, orphans and upper-class Ethiopian and European girls. After providing a brief background to the…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29421400','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29421400"><span>Exploring <span class="hlt">links</span> between greenspace and sudden unexpected <span class="hlt">death</span>: A spatial analysis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wu, Jianyong; Rappazzo, Kristen M; Simpson, Ross J; Joodi, Golsa; Pursell, Irion W; Mounsey, J Paul; Cascio, Wayne E; Jackson, Laura E</p> <p>2018-04-01</p> <p>Greenspace has been increasingly recognized as having numerous health benefits. However, its effects are unknown concerning sudden unexpected <span class="hlt">death</span> (SUD), commonly referred to as sudden cardiac <span class="hlt">death</span>, which constitutes a large proportion of mortality in the United States. Because greenspace can promote physical activity, reduce stress and buffer air pollutants, it may have beneficial effects for people at risk of SUD, such as those with heart disease, hypertension, and diabetes mellitus. Using several spatial techniques, this study explored the relationship between SUD and greenspace. We adjudicated 396 SUD cases that occurred from March 2013 to February 2015 among reports from emergency medical services (EMS) that attended out-of-hospital <span class="hlt">deaths</span> in Wake County (central North Carolina, USA). We measured multiple greenspace metrics in each census tract, including the percentages of forest, grassland, average tree canopy, tree canopy diversity, near-road tree canopy and greenway density. The associations between SUD incidence and these greenspace metrics were examined using Poisson regression (non-spatial) and Bayesian spatial models. The results from both models indicated that SUD incidence was inversely associated with both greenway density (adjusted risk ratio [RR] = 0.82, 95% credible/ confidence interval [CI]: 0.69-0.97) and the percentage of forest (adjusted RR = 0.90, 95% CI: 0.81-0.99). These results suggest that increases in greenway density by 1 km/km 2 and in forest by 10% were associated with a decrease in SUD risk of 18% and 10%, respectively. The inverse relationship was not observed between SUD incidence and other metrics, including grassland, average tree canopy, near-road tree canopy and tree canopy diversity. This study implies that greenspace, specifically greenways and forest, may have beneficial effects for people at risk of SUD. Further studies are needed to investigate potential causal relationships between greenspace and SUD, and</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17044962','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17044962"><span>Sudden <span class="hlt">death</span> in Lesch-Nyhan disease.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Neychev, Vladimir Kostadinov; Jinnah, H A</p> <p>2006-11-01</p> <p>To increase awareness of sudden and unexpected <span class="hlt">death</span> in Lesch-Nyhan disease (LND) and to explore its potential causes, we report the anteceding clinical features and laboratory evaluations of five males with LND who ultimately experienced sudden and unexpected <span class="hlt">death</span>, along with three additional males who suffered serious respiratory events during life. The ages of patients ranged from 2 to 45 years. The cause of sudden <span class="hlt">death</span> in LND appears to have a respiratory rather than a cardiogenic basis. All cases cannot be <span class="hlt">linked</span> readily with a single respiratory process. Instead, different respiratory processes appear to operate in different cases. These may include aspiration, laryngospasm, central apnea, cyanotic breath-holding spells, and high cervical spine damage. Better recognition of these processes will help to guide appropriate workup and management that could include chest imaging, endoscopy of the airways, polysomnography, electroencephalogram, and brain and/or spine imaging.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=sibling+AND+relationship&pg=6&id=EJ818749','ERIC'); return false;" href="https://eric.ed.gov/?q=sibling+AND+relationship&pg=6&id=EJ818749"><span>Improving Emotion Regulation and Sibling Relationship Quality: The More Fun with <span class="hlt">Sisters</span> and Brothers Program</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Kennedy, Denise E.; Kramer, Laurie</p> <p>2008-01-01</p> <p>We examined the role of emotion regulation (ER) in improving sibling relationship quality (SRQ) by evaluating the More Fun With <span class="hlt">Sisters</span> and Brothers Program where 4- to 8-year-old siblings from 95 families were taught emotional and social competencies. Parents reported on SRQ and ER, and sibling interactions were observed in homes. SRQ and ER…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26133120','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26133120"><span>Family member <span class="hlt">deaths</span> across adulthood predict Alzheimer's disease risk: The Cache County Study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Norton, Maria C; Fauth, Elizabeth; Clark, Christine J; Hatch, Dan; Greene, Daylee; Pfister, Roxane; Tschanz, JoAnn T; Smith, Ken R</p> <p>2016-03-01</p> <p>Parental <span class="hlt">death</span> during childhood, and offspring and spouse <span class="hlt">death</span> during adulthood have individually been associated with faster cognitive decline and higher Alzheimer's disease (AD) risk in late life. However, the cumulative effect of childhood and adulthood family <span class="hlt">deaths</span> on AD risk among different age cohorts has not been studied. To examine these associations, this prospective cohort study uses a population-based sample of 4545 initially non-demented participants (56.7% female; age M = 75.0/SD = 6.9 years) observed at four triennial waves, <span class="hlt">linked</span> with objective Utah Population Database data on cumulative mother, father, sibling, spouse, and offspring <span class="hlt">death</span> experienced during childhood and adulthood. Cox regression modeled survival time from baseline interview to AD onset, as a function of family <span class="hlt">deaths</span> during childhood or adulthood, among different age groups, along with gender and presence of ε4 allele at apolipoprotein E (APOE) polymorphic genetic locus. Age group significantly moderated the relationship between family <span class="hlt">death</span> and AD; among persons aged 65-69 years at baseline (children of the Great Depression), those exposed to 3-4 <span class="hlt">deaths</span> and 5+ <span class="hlt">deaths</span> during adulthood exhibited a doubling of AD risk (adjusted hazard ratio, aHR = 2.25, p = .038, and aHR = 2.72, p = .029), while among persons aged 80 years and older, those exposed to 3-4 <span class="hlt">deaths</span> during adulthood exhibited lower AD risk (HR = 0.539, p = 0.014). In a combined model of childhood and adulthood <span class="hlt">deaths</span>, these findings persisted. Results suggest a cohort effect in the <span class="hlt">link</span> between family member <span class="hlt">deaths</span> during adulthood and AD risk later in life. Copyright © 2015 John Wiley & Sons, Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16838904','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16838904"><span>[What is the <span class="hlt">link</span> between the <span class="hlt">sister</span> of the "Titanic" and the history of medicine in Palestine?].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Greenberg, Zalman</p> <p>2006-06-01</p> <p>On 21st November 1916, the Royal Navy Hospital ship 'Britannic' (the <span class="hlt">sister</span> ship of the 'Titanic') was torpedoed near the island of Kea in the Aegean Sea. Captain Dr. John Cropper, aged 52, was one of 30 people who drowned of the 1100 on board. Dr. Cropper was born in 1864, at Guisborough, England. He obtained his medical degree from Cambridge University in 1891. After his marriage to Anne Ellen Walker in 1895, the Church Missionary Society sent him on a medical mission to Palestine. Dr. Cropper stayed in Palestine for about 10 years working in Acre, Nablus, Ramallah and Jerusalem. He published his experiences in 35 articles and letters in English medical periodicals, more than anyone else did in Palestine at that time. In those publications, he described various operations that he carried out and observations on infectious diseases, most of which were the first descriptions from that remote and unhealthy country. His prominent research was in the field of malaria - the most common and important disease in Palestine during that period. It was less than two years after Grassi's discovery of the role of Anopheles mosquitoes as the vector of human malaria that Dr. Cropper carried out surveys of larval and adult mosquitoes in correlation with malarial distribution in Palestine. Dr. Cropper was the first who routinely examined slides microscopically in Palestine and correctly diagnosed the type of malaria. Dr. Cropper was also the first in Palestine to suggest antimalarial measures aimed directly at the mosquito vector and paid attention to ecological aspects such as breeding places and the daily behavior of adult mosquitoes. Dr. Cropper noted the common antimalarial measurements of that time, such as covering of wells, planting of Eucalyptus trees to drain swamps and the routine use of quinine as a preventive medicine, but he wrote that those measures were not effective under the local conditions. He suggested that the only effective measures must be aimed against the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16225223','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16225223"><span>The <span class="hlt">death</span> of Adolf Hitler--forensic aspects.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Marchetti, Daniela; Boschi, Ilaria; Polacco, Matteo; Rainio, Juha</p> <p>2005-09-01</p> <p>The <span class="hlt">death</span> of Adolf Hitler is one of the unsolved mysteries of the twentieth century. Numerous historians and journalists have attempted to piece together the details, but despite the interest in the forensic literature regarding the identification of the body, there has not been much scientific debate about the alleged cause of <span class="hlt">death</span>--cyanide poisoning, gunshot injury, or both. The available literature concerning Hitler's cause of <span class="hlt">death</span> is incomplete because the toxicological analysis has not been performed and because the skull bone fragment with a gunshot wound possibly from Hitler's corpse has not been properly examined. This has given basis for various theories, which are reviewed. We believe that mtDNA analysis of the skull fragments and of Hitler's jaw, now filed in Moscow, and samples from maternal relatives of Hitler are crucial <span class="hlt">linking</span> the skull fragment with the gunshot wound to Hitler.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3078076','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3078076"><span>Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for <span class="hlt">sister</span>-chromatid cohesion in human cells</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kang, Jungseog; Chaudhary, Jaideep; Dong, Hui; Kim, Soonjoung; Brautigam, Chad A.; Yu, Hongtao</p> <p>2011-01-01</p> <p>Human Shugoshin 1 (Sgo1) protects centromeric <span class="hlt">sister</span>-chromatid cohesion during prophase and prevents premature <span class="hlt">sister</span>-chromatid separation. Heterochromatin protein 1 (HP1) has been proposed to protect centromeric <span class="hlt">sister</span>-chromatid cohesion by directly targeting Sgo1 to centromeres in mitosis. Here we show that HP1α is targeted to mitotic centromeres by INCENP, a subunit of the chromosome passenger complex (CPC). Biochemical and structural studies show that both HP1–INCENP and HP1–Sgo1 interactions require the binding of the HP1 chromo shadow domain to PXVXL/I motifs in INCENP or Sgo1, suggesting that the INCENP-bound, centromeric HP1α is incapable of recruiting Sgo1. Consistently, a Sgo1 mutant deficient in HP1 binding is functional in centromeric cohesion protection and localizes normally to centromeres in mitosis. By contrast, INCENP or Sgo1 mutants deficient in HP1 binding fail to localize to centromeres in interphase. Therefore, our results suggest that HP1 binding by INCENP or Sgo1 is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet uncharacterized interphase functions of CPC or Sgo1 at the centromeres. PMID:21346195</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29113878','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29113878"><span>[Maternal <span class="hlt">deaths</span> related to social vulnerabilities. Results from the French confidential enquiry into maternal <span class="hlt">deaths</span>, 2010-2012].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tessier, V; Leroux, S; Guseva-Canu, I</p> <p>2017-12-01</p> <p>The theme of deprivation is new for the ENCMM. In view of the perceived increase in the number of maternal <span class="hlt">deaths</span> that may be related to a deprivation situation, we sought to understand the main dimensions that could contribute to maternal <span class="hlt">death</span> in this context, in order to propose a definition. The selection of cases made a posteriori is mainly based on a qualitative judgment. Between 2010 and 2012, among the <span class="hlt">deaths</span> evaluated by the CNEMM, one or more elements related to social vulnerability were identified in 8.6% of the cases (18 <span class="hlt">deaths</span>). The direct criteria used were the concepts of "deprivation" or "social difficulties", difficulties of housing, language barriers and isolation. The absence of prenatal care was retained as an indirect marker. We excluded cases where psychiatric pathology and/or addiction were predominant. Of the 18 cases identified with deprivation factors, <span class="hlt">death</span> was considered "unavoidable" in 2 cases (11%), "certainly avoidable" or "possibly avoidable" in 13 cases (72%). In 3 cases (17%), avoidability could not be determined. Avoidability was related to the content and adequacy of care in 11 cases out of 13 (85%) and the patient's interaction with the health care system in 10 of 18 cases (56%). The analysis of maternal <span class="hlt">deaths</span> among women in precarious situations points out that the <span class="hlt">link</span> between socio-economic deprivation and poor maternal health outcomes potentially includes a specific risk of maternal <span class="hlt">death</span>. Copyright © 2017 Elsevier Masson SAS. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3178589','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3178589"><span>Estimating Pneumonia <span class="hlt">Deaths</span> of Post-Neonatal Children in Countries of Low or No <span class="hlt">Death</span> Certification in 2008</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Theodoratou, Evropi; Zhang, Jian Shayne F.; Kolcic, Ivana; Davis, Andrew M.; Bhopal, Sunil; Nair, Harish; Chan, Kit Yee; Liu, Li; Johnson, Hope; Rudan, Igor; Campbell, Harry</p> <p>2011-01-01</p> <p>Background Pneumonia is the leading cause of child <span class="hlt">deaths</span> globally. The aims of this study were to: a) estimate the number and global distribution of pneumonia <span class="hlt">deaths</span> for children 1–59 months for 2008 for countries with low (<85%) or no coverage of <span class="hlt">death</span> certification using single-cause regression models and b) compare these country estimates with recently published ones based on multi-cause regression models. Methods and Findings For 35 low child-mortality countries with <85% coverage of <span class="hlt">death</span> certification, a regression model based on vital registration data of low child-mortality and >85% coverage of <span class="hlt">death</span> certification countries was used. For 87 high child-mortality countries pneumonia <span class="hlt">death</span> estimates were obtained by applying a regression model developed from published and unpublished verbal autopsy data from high child-mortality settings. The total number of 1–59 months pneumonia <span class="hlt">deaths</span> for the year 2008 for these 122 countries was estimated to be 1.18 M (95% CI 0.77 M–1.80 M), which represented 23.27% (95% CI 17.15%–32.75%) of all 1–59 month child <span class="hlt">deaths</span>. The country level estimation correlation coefficient between these two methods was 0.40. Interpretation Although the overall number of post-neonatal pneumonia <span class="hlt">deaths</span> was similar irrespective to the method of estimation used, the country estimate correlation coefficient was low, and therefore country-specific estimates should be interpreted with caution. Pneumonia remains the leading cause of child <span class="hlt">deaths</span> and is greatest in regions of poverty and high child-mortality. Despite the concerns about gender inequity <span class="hlt">linked</span> with childhood mortality we could not estimate sex-specific pneumonia mortality rates due to the inadequate data. Life-saving interventions effective in preventing and treating pneumonia mortality exist but few children in high pneumonia disease burden regions are able to access them. To achieve the United Nations Millennium Development Goal 4 target to reduce child <span class="hlt">deaths</span> by two</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19168356','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19168356"><span>Cell-cycle control in the face of damage--a matter of life or <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Clarke, Paul R; Allan, Lindsey A</p> <p>2009-03-01</p> <p>Cells respond to DNA damage or defects in the mitotic spindle by activating checkpoints that arrest the cell cycle. Alternatively, damaged cells can undergo cell <span class="hlt">death</span> by the process of apoptosis. The correct balance between these pathways is important for the maintenance of genomic integrity while preventing unnecessary cell <span class="hlt">death</span>. Although the molecular mechanisms of the cell cycle and apoptosis have been elucidated, the <span class="hlt">links</span> between them have not been clear. Recent work, however, indicates that common components directly <span class="hlt">link</span> the regulation of apoptosis with cell-cycle checkpoints operating during interphase, whereas in mitosis, the control of apoptosis is directly coupled to the cell-cycle machinery. These findings shed new light on how the balance between cell-cycle progression and cell <span class="hlt">death</span> is controlled.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5346962','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5346962"><span>Substance P/Neurokinin 1 and Trigeminal System: A Possible <span class="hlt">Link</span> to the Pathogenesis in Sudden Perinatal <span class="hlt">Deaths</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mehboob, Riffat</p> <p>2017-01-01</p> <p>Sudden demise of a healthy fetus or a neonate is a very tragic episode in the life of parents. These <span class="hlt">deaths</span> have been a mystery since ages but still remain unexplained. This review proposes the involvement of trigeminal nerve, neurotransmitter substance P (SP), and its receptor neurokinin 1 (NK-1R) in regulation of cardiorespiratory control in fetuses and newborns. Anomalies and immaturity of neuroregulatory systems such as trigeminal system in medulla oblongata of brainstem may provide a possible mechanism of sudden perinatal <span class="hlt">deaths</span>. Vulnerable infants are born with respiratory center immaturity which in combination with any stressor such as cold, hypoxia, and smoking may lead to cessation of breathing and ventilatory response. SP/NK-1R may be involved in regulating the ventilatory control in neonates while it is decreased in fetal and adult life in humans, and any alterations from these may lead to irreversible sleep apnea and fatal breathing, ultimately sudden <span class="hlt">death</span>. This review summarizes the studies performed to highlight the expression of SP or NK-1R in sudden perinatal <span class="hlt">deaths</span> and proposes the involvement of trigeminal ganglion along with its nerve and SP/NK-1R expression alteration as one of the possible pathophysiological underlying mechanism. However, further studies are required to explore the role of SP, NK-1R, and trigeminal system in the pathogenesis of sudden infant <span class="hlt">deaths</span>, sudden intrauterine <span class="hlt">deaths</span>, stillbirths, and sudden <span class="hlt">deaths</span> later in human life. PMID:28348544</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28348544','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28348544"><span>Substance P/Neurokinin 1 and Trigeminal System: A Possible <span class="hlt">Link</span> to the Pathogenesis in Sudden Perinatal <span class="hlt">Deaths</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mehboob, Riffat</p> <p>2017-01-01</p> <p>Sudden demise of a healthy fetus or a neonate is a very tragic episode in the life of parents. These <span class="hlt">deaths</span> have been a mystery since ages but still remain unexplained. This review proposes the involvement of trigeminal nerve, neurotransmitter substance P (SP), and its receptor neurokinin 1 (NK-1R) in regulation of cardiorespiratory control in fetuses and newborns. Anomalies and immaturity of neuroregulatory systems such as trigeminal system in medulla oblongata of brainstem may provide a possible mechanism of sudden perinatal <span class="hlt">deaths</span>. Vulnerable infants are born with respiratory center immaturity which in combination with any stressor such as cold, hypoxia, and smoking may lead to cessation of breathing and ventilatory response. SP/NK-1R may be involved in regulating the ventilatory control in neonates while it is decreased in fetal and adult life in humans, and any alterations from these may lead to irreversible sleep apnea and fatal breathing, ultimately sudden <span class="hlt">death</span>. This review summarizes the studies performed to highlight the expression of SP or NK-1R in sudden perinatal <span class="hlt">deaths</span> and proposes the involvement of trigeminal ganglion along with its nerve and SP/NK-1R expression alteration as one of the possible pathophysiological underlying mechanism. However, further studies are required to explore the role of SP, NK-1R, and trigeminal system in the pathogenesis of sudden infant <span class="hlt">deaths</span>, sudden intrauterine <span class="hlt">deaths</span>, stillbirths, and sudden <span class="hlt">deaths</span> later in human life.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16131840','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16131840"><span>Telomere <span class="hlt">sister</span> chromatid exchange in telomerase deficient murine cells.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wang, Yisong; Giannone, Richard J; Liu, Yie</p> <p>2005-10-01</p> <p>We have recently demonstrated that several types of genomic rearrangements (i.e., telomere <span class="hlt">sister</span> chromatid exchange (T-SCE), genomic-SCE, or end-to-end fusions) were more often detected in long-term cultured murine telomerase deficient embryonic stem (ES) cells than in freshly prepared murine splenocytes, even through they possessed similar frequencies of critically short telomeres. The high rate of genomic rearrangements in telomerase deficient ES cells, when compared to murine splenocytes, may reflect the cultured cells' gained ability to protect chromosome ends with eroded telomeres allowing them to escape "end crisis". However, the possibility that ES cells were more permissive to genomic rearrangements than other cell types or that differences in the microenvironment or genetic background of the animals might consequentially determine the rate of T-SCEs or other genomic rearrangements at critically short telomeres could not be ruled out.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_13 --> <div id="page_14" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="261"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5262440','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5262440"><span>Risk of <span class="hlt">Death</span> for Veterans on Release From Prison</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wortzel, Hal S.; Blatchford, Patrick; Conner, Latoya; Adler, Lawrence E.; Binswanger, Ingrid A.</p> <p>2017-01-01</p> <p>We sought to determine, among veterans released from Washington state prisons from 1999 through 2003, the risk of <span class="hlt">death</span> from all causes, whether those veterans have faced a higher risk of <span class="hlt">death</span> than have nonveterans, and whether having VA benefits decreased the risk of <span class="hlt">death</span>. We <span class="hlt">linked</span> data from a retrospective cohort study to data from the Veterans Benefit Administration. Mortality rates were compared between veteran and nonveteran former inmates. The crude rate of veteran mortality was 1,195 per 100,000 person-years, significantly higher than that of nonveterans (p < .001), but adjustment for demographic factors demonstrated no significant increased risk. VA benefits were associated with a reduced risk for all-cause <span class="hlt">deaths</span> (hazard ratio, .376; 95% confidence interval, 0.18–0.79). Veterans share the heightened risk of <span class="hlt">death</span> after release from prison faced by all released inmates and should be included in efforts to reduce the risks associated with transitioning from prison to the community. VA benefits appear to offer a protective effect, particularly against medical <span class="hlt">deaths</span>. PMID:22960917</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28949788','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28949788"><span>Care at End of Life Influences Grief: A Nationwide Long-Term Follow-Up among Young Adults Who Lost a Brother or <span class="hlt">Sister</span> to Childhood Cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lövgren, Malin; Sveen, Josefin; Nyberg, Tommy; Eilegård Wallin, Alexandra; Prigerson, Holly G; Steineck, Gunnar; Kreicbergs, Ulrika</p> <p>2018-02-01</p> <p>A majority of cancer-bereaved siblings report long-term unresolved grief, thus it is important to identify factors that may contribute to resolving their grief. To identify modifiable or avoidable family and care-related factors associated with unresolved grief among siblings two to nine years post loss. This is a nationwide Swedish postal survey. Study-specific questions and the standardized instrument Hospital Anxiety and Depression Scale. Primary outcome was unresolved grief, and family and care-related factors were used as predictors. Cancer-bereaved sibling (N = 174) who lost a brother/<span class="hlt">sister</span> to childhood cancer during 2000-2007 in Sweden (participation rate 73%). Seventy-three were males and 101 females. The age of the siblings at time of loss was 12-25 years and at the time of the survey between 19 and 33 years. Several predictors for unresolved grief were identified: siblings' perception that it was not a peaceful <span class="hlt">death</span> [odds ratio (OR): 9.86, 95% confidence interval (CI): 2.39-40.65], limited information given to siblings the last month of life (OR: 5.96, 95% CI: 1.87-13.68), information about the impending <span class="hlt">death</span> communicated the day before it occurred (OR: 2.73, 95% CI: 1.02-7.33), siblings' avoidance of the doctors (OR: 3.22, 95% CI: 0.75-13.76), and lack of communication with family (OR: 2.86, 95% CI: 1.01-8.04) and people outside the family about <span class="hlt">death</span> (OR: 5.07, 95% CI: 1.64-15.70). Depressive symptoms (OR: 1.27, 95% CI: 1.12-1.45) and time since loss (two to four years: OR: 10.36, 95% CI: 2.87-37.48 and five to seven years: OR: 8.36, 95% CI: 2.36-29.57) also predicted unresolved grief. Together, these predictors explained 54% of the variance of unresolved grief. Siblings' perception that it was not a peaceful <span class="hlt">death</span> and poor communication with family, friends, and healthcare increased the risk for unresolved grief among the siblings.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23772196','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23772196"><span>Narcolepsy with cataplexy mimicry: the strange case of two <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pizza, Fabio; Vandi, Stefano; Poli, Francesca; Moghadam, Keivan Kaveh; Franceschini, Christian; Bellucci, Claudia; Cipolli, Carlo; Ingravallo, Francesca; Natalini, Giuliana; Mignot, Emmanuel; Plazzi, Giuseppe</p> <p>2013-06-15</p> <p>We report on two <span class="hlt">sisters</span>, 17 and 12 years of age, with clinical features suggesting narcolepsy with cataplexy (NC): daytime sleepiness, spontaneous and emotionally triggered sudden falls to the ground, and overweight/obesity. MSLT showed borderline sleep latency, with 1 and 0 sleep onset REM periods. HLA typing disclosed the DQB1*0602 allele. Video-polygraphy of the spells ruled out NC diagnosis by demonstrating their easy elicitation by suggestion, with wake EEG, electromyographic persistence of muscle tone, and stable presence of tendon reflexes (i.e., pseudo-cataplexy), together with normal cerebrospinal hypocretin-1 levels. Our cases emphasize the need of a clear depiction of cataplexy pattern at the different ages, the usefulness of examining ictal neurophysiology, and collecting all available disease markers in ambiguous cases.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28572021','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28572021"><span><span class="hlt">Death</span> certificate data and causes of <span class="hlt">death</span> in patients with parkinsonism.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Moscovich, Mariana; Boschetti, Gabriela; Moro, Adriana; Teive, Helio A G; Hassan, Anhar; Munhoz, Renato P</p> <p>2017-08-01</p> <p>Assessment of variables related to mortality in Parkinson disease (PD) and other parkinsonian syndromes relies, among other sources, on accurate <span class="hlt">death</span> certificate (DC) documentation. We assessed the documentation of the degenerative disorder on DCs and evaluated comorbidities and causes of <span class="hlt">death</span> among parkinsonian patients. Demographic and clinical data were systematically and prospectively collected on deceased patients followed at a tertiary movement disorder clinic. DCs data included the documentation of parkinsonism, causes, and place of <span class="hlt">death</span>. Among 138 cases, 84 (60.9%) male, mean age 77.9 years, mean age of onset 66.7, and mean disease duration 10.9 years. Clinical diagnoses included PD (73.9%), progressive supranuclear palsy (10.9%), multiple system atrophy (7.2%), Lewy body dementia (7.2%) and corticobasal degeneration (0.7%). Psychosis occurred in 60.1% cases, dementia in 48.5%. Most PD patients died due to heterogeneous causes before reaching advanced stages. Non-PD parkinsonian patients died earlier due to causes <span class="hlt">linked</span> to the advanced neurodegenerative process. PD was documented in 38.4% of DCs with different forms of inconsistencies. That improved, but remained significant when it was signed by a specialist. More than half of PD cases died while still ambulatory and independent, after a longer disease course and due to causes commonly seen in that age group. <span class="hlt">Deaths</span> among advanced PD patients occurred due to causes similar to what we found in non-PD cases. These findings can be useful for clinical, prognostic and counseling purposes. Underlying parkinsonian disorders are poorly documented in DCs, undermining its' use as sources of data collection. Copyright © 2017 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.jstor.org/stable/10.5403/oregonhistq.114.4.0402','USGSPUBS'); return false;" href="http://www.jstor.org/stable/10.5403/oregonhistq.114.4.0402"><span>“Our vanishing glaciers”: One hundred years of glacier retreat in Three <span class="hlt">Sisters</span> Area, Oregon Cascade Range</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>O'Connor, James E.</p> <p>2014-01-01</p> <p>In August 1910, thirty-nine members of the Mazamas Mountaineering Club ascended the peaks of the Three <span class="hlt">Sisters</span> in central Oregon. While climbing, geologist Ira A. Williams photographed the surrounding scenery, including images of Collier Glacier. One hundred years later, U.S. Geological Survey research hydrologist Jim E. O’Connor matched those documented photographs with present day images — the result of which is a stunning lapse of glacial change in the Three <span class="hlt">Sister</span> region. O’Connor asserts that “glaciers exist by the grace of climate,” and through a close examination of the history of the region’s glaciers, he provides an intriguing glimpse into the history of geological surveys and glacial studies in the Pacific Northwest, including their connection to significant scientific advances of the nineteenth century. The work of scientists and mountaineers who have monitored and recorded glacier changes for over a century allows us to see dramatic changes in a landscape that is especially sensitive to ongoing climate change.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19762677','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19762677"><span>The Hispanic mortality advantage and ethnic misclassification on US <span class="hlt">death</span> certificates.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Arias, Elizabeth; Eschbach, Karl; Schauman, William S; Backlund, Eric L; Sorlie, Paul D</p> <p>2010-04-01</p> <p>We tested the data artifact hypothesis regarding the Hispanic mortality advantage by investigating whether and to what degree this advantage is explained by Hispanic origin misclassification on US <span class="hlt">death</span> certificates. We used the National Longitudinal Mortality Study, which <span class="hlt">links</span> Current Population Survey records to <span class="hlt">death</span> certificates for 1979 through 1998, to estimate the sensitivity, specificity, and net ascertainment of Hispanic ethnicity on <span class="hlt">death</span> certificates compared with survey classifications. Using national vital statistics mortality data, we estimated Hispanic age-specific and age-adjusted <span class="hlt">death</span> rates, which were uncorrected and corrected for <span class="hlt">death</span> certificate misclassification, and produced <span class="hlt">death</span> rate ratios comparing the Hispanic with the non-Hispanic White population. Hispanic origin reporting on <span class="hlt">death</span> certificates in the United States is reasonably good. The net ascertainment of Hispanic origin is just 5% higher on survey records than on <span class="hlt">death</span> certificates. Corrected age-adjusted <span class="hlt">death</span> rates for Hispanics are lower than those for the non-Hispanic White population by close to 20%. The Hispanic mortality paradox is not explained by an incongruence between ethnic classification in vital registration and population data systems.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Madan&pg=4&id=EJ484723','ERIC'); return false;" href="https://eric.ed.gov/?q=Madan&pg=4&id=EJ484723"><span>Family Adaptation and Coping among Siblings of Cancer Patients, Their Brothers and <span class="hlt">Sisters</span>, and Nonclinical Controls.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Madan-Swain, Avi; And Others</p> <p>1993-01-01</p> <p>Examined coping and family adaptation in siblings (n=32) of cancer patients, their ill brothers and <span class="hlt">sisters</span> (n=19), and control group of nonclinical children (n=10) with healthy siblings. Gender and age of sibling, birth order, and number of siblings were examined. Found better adaptation in larger families and decreased family involvement among…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.fs.usda.gov/treesearch/pubs/43742','TREESEARCH'); return false;" href="https://www.fs.usda.gov/treesearch/pubs/43742"><span>Historical biogeography and diversification of truffles in the Tuberaceae and their newly identified Southern hemisphere <span class="hlt">sister</span> lineage</span></a></p> <p><a target="_blank" href="http://www.fs.usda.gov/treesearch/">Treesearch</a></p> <p>Gregory Bonito; Matthew E. Smith; Michael Nowak; Rosanne A. Healy; Gonzalo Guevara; Efren Cazares; Akihiko Kinoshita; Eduardo R. Nouhra; Laura S. Dominguez; Leho Tedersoo; Claude Murat; Yun Wang; Baldomero Arroyo Moreno; Donald H. Pfister; Kazuhide Nara; Alessandra Zambonelli; James M. Trappe; Rytas Vilgalys</p> <p>2013-01-01</p> <p>In this study we reassessed the biogeography and origin of the Tuberaceae and their relatives using multiple loci and a global sampling of taxa. Multiple independent transitions from an aboveground to a belowground truffie fruiting body form have occurred in the Tuberaceae and in its newly recognized <span class="hlt">sister</span> lineage...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3428847','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3428847"><span><span class="hlt">Linking</span> families and facilities for care at birth: What works to avert intrapartum-related <span class="hlt">deaths</span>?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lee, Anne CC; Lawn, Joy E.; Cousens, Simon; Kumar, Vishwajeet; Osrin, David; Bhutta, Zulfiqar A.; Wall, Steven N.; Nandakumar, Allyala K.; Syed, Uzma; Darmstadt, Gary L.</p> <p>2012-01-01</p> <p>Background Delays in receiving effective care during labor and at birth may be fatal for the mother and fetus, contributing to 2 million annual intrapartum stillbirths and intrapartum-related neonatal <span class="hlt">deaths</span> each year. Objective We present a systematic review of strategies to <span class="hlt">link</span> families and facilities, including community mobilization, financial incentives, emergency referral and transport systems, prenatal risk screening, and maternity waiting homes. Results There is moderate quality evidence that community mobilization with high levels of community engagement can increase institutional births and significantly reduce perinatal and early neonatal mortality. Meta-analysis showed a doubling of skilled birth attendance and a 35% reduction in early neonatal mortality. However, no data are available on intrapartum-specific outcomes. Evidence is limited, but promising, that financial incentive schemes and community referral/transport systems may increase rates of skilled birth attendance and emergency obstetric care utilization; however, impact on mortality is unknown. Current evidence for maternity waiting homes and risk screening is low quality. Conclusions Empowering communities is an important strategy to reduce the large burden of intrapartum complications. Innovations are needed to bring the poor closer to obstetric care, such as financial incentives and cell phone technology. New questions need to be asked of “old” strategies such as risk screening and maternity waiting homes. The effect of all of these strategies on maternal and perinatal mortality, particularly intrapartum-related outcomes, requires further evaluation. PMID:19815201</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/58452','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/58452"><span>Geologic map of the Three <span class="hlt">Sisters</span> Wilderness, Deschutes, Lane, and Linn counties, Oregon</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Taylor, E.M.; MacLeod, N.S.; Sherrod, D.R.; Walker, G.W.</p> <p>1987-01-01</p> <p>The Wilderness Act (Public Law 88-577, September 3, 1964) and related acts require the U.S. Geological Survey and the U.S. Bureau of Mines to survey certain areas on Federal lands to determine the mineral values, if any, that may be present. Results must be made available to the public and to be submitted to the President and Congress. This report presents the results of a geologic survey of the Three <span class="hlt">Sisters</span> Wilderness, Deschutes and Willamette National Forests, Deschutes, Lane and Linn Counties, Oregon</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2007SunGe...2...78S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2007SunGe...2...78S"><span>Monthly <span class="hlt">Deaths</span> Number And Concomitant Environmental Physical Activity: 192 Months Observation (1990-2005)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Stoupel, E.; Kalediene, R.; Petrauskiene, J.; Starkuviene, S.; Abramson, E.; Israelevich, P.; Sulkes, J.</p> <p>2007-12-01</p> <p>Human life and health state are dependent on many endogenous and exogenous influence factors. The aim of this study is to check the possible <span class="hlt">links</span> between monthly <span class="hlt">deaths</span> distribution and concomitant activity of three groups of cosmophysical factors: solar (SA), geomagnetic (GMA) and cosmic ray (CRA) activities. 192 months <span class="hlt">death</span> number in years 1990-2005 (n=674004) at the Republic of Lithuania were analyzed. Total and both gender data were considered. In addition to the total <span class="hlt">death</span> numbers, groups of ischemic heart disease (IHD), stroke (CVA), non-cardiovascular (NCV), accident, traffic accident and suicide-related <span class="hlt">deaths</span> were studied. Sunspot number and solar radio flux (for SA), Ap, Cp and Am indices (for GMA) and neutron activity on the Earth s surface (for CRA) were the environmental physical activity parameters used in this study. Yearly and monthly <span class="hlt">deaths</span> distributions were also studied. Pearson correlation coefficients (r) and their probabilities (p) were calculated. Multivariate analysis was conducted. Results revealed: 1) significant correlation of monthly <span class="hlt">deaths</span> number with CRA (total, stroke, NCV and suicides) and inverse with SA and GMA; 2) significant correlation of monthly number of traffic accidents number with SA and GMA, and inverse with CRA; 3) a strong negative relationship between year and IHD/CVA victims number (an evidence for growing role of stroke in cardiovascular mortality); 4) significant <span class="hlt">links</span> of rising cardiovascular <span class="hlt">deaths</span> number at the beginning of the year and traffic accidents victims at the end of the year. It is concluded that CRA is related to monthly <span class="hlt">deaths</span> distribution.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27537325','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27537325"><span>Surveillance for Violent <span class="hlt">Deaths</span> - National Violent <span class="hlt">Death</span> Reporting System, 17 States, 2013.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lyons, Bridget H; Fowler, Katherine A; Jack, Shane P D; Betz, Carter J; Blair, Janet M</p> <p>2016-08-19</p> <p>In 2013, more than 57,000 persons died in the United States as a result of violence-related injuries. This report summarizes data from CDC's National Violent <span class="hlt">Death</span> Reporting System (NVDRS) regarding violent <span class="hlt">deaths</span> from 17 U.S. states for 2013. Results are reported by sex, age group, race/ethnicity, marital status, location of injury, method of injury, circumstances of injury, and other selected characteristics. 2013. NVDRS collects data from participating states regarding violent <span class="hlt">deaths</span> obtained from <span class="hlt">death</span> certificates, coroner/medical examiner reports, law enforcement reports, and secondary sources (e.g., child fatality review team data, supplemental homicide reports, hospital data, and crime laboratory data). This report includes data from 17 states that collected statewide data for 2013 (Alaska, Colorado, Georgia, Kentucky, Maryland, Massachusetts, North Carolina, New Jersey, New Mexico, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Virginia, and Wisconsin). NVDRS collates documents for each <span class="hlt">death</span> and <span class="hlt">links</span> <span class="hlt">deaths</span> that are related (e.g., multiple homicides, a homicide followed by a suicide, or multiple suicides) from a single incident. For 2013, a total of 18,765 fatal incidents involving 19,251 <span class="hlt">deaths</span> were captured by NVDRS in the 17 states included in this report. The majority (66.2%) of <span class="hlt">deaths</span> were suicides, followed by homicides (23.2%), <span class="hlt">deaths</span> of undetermined intent (8.8%), <span class="hlt">deaths</span> involving legal intervention (1.2%) (i.e., <span class="hlt">deaths</span> caused by law enforcement and other persons with legal authority to use deadly force, excluding legal executions), and unintentional firearm <span class="hlt">deaths</span> (<1%). (The term legal intervention is a classification incorporated into the International Classification of Diseases, Tenth Revision [ICD-10] and does not denote the lawfulness or legality of the circumstances surrounding a <span class="hlt">death</span> caused by law enforcement.) Suicides occurred at higher rates among males, non-Hispanic whites, American Indian/Alaska Natives, persons aged 45</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29471294','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29471294"><span>Novel Familial Variant of the Desert Hedgehog Gene: Clinical Findings in Two <span class="hlt">Sisters</span> with 46,XY Gonadal Dysgenesis or 46,XX Karyotype and Literature Review.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Baldinotti, Fulvia; Cavallaro, Tiziana; Dati, Eleonora; Baroncelli, Giampiero I; Bertini, Veronica; Valetto, Angelo; Massart, Francesco; Fabrizi, Gian Maria; Zanette, Giampietro; Peroni, Diego; Bertelloni, Silvano</p> <p>2018-01-01</p> <p>In humans, Desert Hedgehog (DHH) gene mutations are a very rare cause of 46,XY gonadal dysgenesis (GD), eventually associated with peripheral neuropathy. Clinical records of 12 patients with 46,XY GD and unknown genetic background were reviewed and a 46,XY woman with peripheral neuropathy was individuated. Her 46,XX <span class="hlt">sister</span> affected by similar neuropathy was also investigated. Genomic DNA was extracted and DHH exons sequenced and analyzed. A comparative genomic hybridization array was also performed. In both the 46,XY and 46,XX <span class="hlt">sisters</span>, a homozygous c.554C>A mutation in exon 2 of the DHH gene was found, determining a premature termination codon (p.Ser 185*). Heterozygous consanguineous carrier parents showed neither reproductive problems nor peripheral neuropathy. In the proband and her <span class="hlt">sister</span>, a 499-kb duplication in 9p22.1 was also found. A 46,XY European woman with 46,XY GD and a novel homozygous DHH pathogenic variant is reported, confirming that this gene plays a key role in male gonadal development. Her 46,XX <span class="hlt">sister</span>, harboring the same mutation, showed normal internal and external female phenotype. Thus, DHH seems not to be involved in the ovarian development pathway or its postpubertal function. Homozygous DHH mutations cause a specific peripheral neuropathy in humans with both 46,XY and 46,XX karyotypes. © 2018 S. Karger AG, Basel.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/978252-telomere-sister-chromatid-exchange-telomerase-deficient-murine-cells','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/978252-telomere-sister-chromatid-exchange-telomerase-deficient-murine-cells"><span>Telomere <span class="hlt">sister</span> chromatid exchange in telomerase deficient murine cells</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Wang, Yisong; Giannone, Richard J; Liu, Yie</p> <p>2005-01-01</p> <p>We have recently demonstrated that several types of genomic rearrangements (i.e., telomere <span class="hlt">sister</span> chromatid exchange (T-SCE), genomic-SCE, or end-to-end fusions) were more often detected in long-term cultured murine telomerase deficient embryonic stem (ES) cells than in freshly prepared murine splenocytes, even through they possessed similar frequencies of critically short telomeres. The high rate of genomic rearrangements in telomerase deficient ES cells, when compared to murine splenocytes, may reflect the cultured cells' gained ability to protect chromosome ends with eroded telomeres allowing them to escape 'end crisis'. However, the possibility that ES cells were more permissive to genomic rearrangements than othermore » cell types or that differences in the microenvironment or genetic background of the animals might consequentially determine the rate of T-SCEs or other genomic rearrangements at critically short telomeres could not be ruled out.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24815211','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24815211"><span>Tracheole investment does not vary with body size among bumblebee (Bombus impatiens) <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Vogt, Jessica R; Dillon, Megan K; Dillon, Michael E</p> <p>2014-08-01</p> <p>Body size is a key organism trait with critical implications for the physiology, life history, and ecology of organisms. Modern insects vary in body mass by over 6 orders of magnitude, but are small by comparison to many other metazoan taxa. The small size of modern insects may reflect limitations imposed by their open respiratory systems which rely, in part, on diffusion. Diffusion rates decline with distance such that, absent compensation, the capacity for larger insects to deliver oxygen to their tissues may be compromised. To compensate, larger grasshoppers, beetles, and bumblebees devote proportionally more of their body volume to the respiratory system, as demonstrated by hypermetric scaling of tracheal volume with body mass(>1). Among bumblebee <span class="hlt">sisters</span>, total respiratory volume scaled with mass(2.6), but it is unclear at what level or levels of the tracheal system (main tracheal trunks, air sacs, tracheoles) bumblebees express this extreme hypermetry. Here we use transmission electron microscopy to examine the morphology of tracheoles in bumblebee flight muscle among <span class="hlt">sister</span> bumblebees varying nearly four-fold in body mass. Neither tracheole density nor tracheole diameter changed with body mass. The total cross-sectional area of tracheoles was also invariant with body mass. Together, these results reveal that bumblebees do not compensate for size-related limitations on oxygen delivery by increasing investment at the level of the tracheoles. Copyright © 2014 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=nun+AND+study&pg=3&id=ED523978','ERIC'); return false;" href="https://eric.ed.gov/?q=nun+AND+study&pg=3&id=ED523978"><span>The Discernment Process of the <span class="hlt">Sisters</span> of Saint Dominic regarding the Continued Sponsorship of Its Secondary Schools</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tavis, Patricia</p> <p>2010-01-01</p> <p>The purpose of this dissertation was to examine the factors that a congregation of women religious, the <span class="hlt">Sisters</span> of Saint Dominic of Caldwell, New Jersey, must consider in order to continue its sponsored relationship and the extent of this sponsored relationship with its secondary educational ministries for the future. This descriptive and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29666938','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29666938"><span>Multigene phylogeny and cell evolution of chromist infrakingdom Rhizaria: contrasting cell organisation of <span class="hlt">sister</span> phyla Cercozoa and Retaria.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cavalier-Smith, Thomas; Chao, Ema E; Lewis, Rhodri</p> <p>2018-04-17</p> <p>Infrakingdom Rhizaria is one of four major subgroups with distinct cell body plans that comprise eukaryotic kingdom Chromista. Unlike other chromists, Rhizaria are mostly heterotrophic flagellates, amoebae or amoeboflagellates, commonly with reticulose (net-like) or filose (thread-like) feeding pseudopodia; uniquely for eukaryotes, cilia have proximal ciliary transition-zone hub-lattices. They comprise predominantly flagellate phylum Cercozoa and reticulopodial phylum Retaria, whose exact phylogenetic relationship has been uncertain. Given even less clear relationships amongst cercozoan classes, we sequenced partial transcriptomes of seven Cercozoa representing five classes and endomyxan retarian Filoreta marina to establish 187-gene multiprotein phylogenies. Ectoreta (retarian infraphyla Foraminifera, Radiozoa) branch within classical Cercozoa as <span class="hlt">sister</span> to reticulose Endomyxa. This supports recent transfer of subphylum Endomyxa from Cercozoa to Retaria alongside subphylum Ectoreta which embraces classical retarians where capsules or tests subdivide cells into organelle-containing endoplasm and anastomosing pseudopodial net-like ectoplasm. Cercozoa are more homogeneously filose, often with filose pseudopodia and/or posterior ciliary gliding motility: zooflagellate Helkesimastix and amoeboid Guttulinopsis form a strongly supported clade, order Helkesida. Cercomonads are polyphyletic (Cercomonadida <span class="hlt">sister</span> to glissomonads; Paracercomonadida deeper). Thecofilosea are a clade, whereas Imbricatea may not be; Sarcomonadea may be paraphyletic. Helkesea and Metromonadea are successively deeper outgroups within cercozoan subphylum Monadofilosa; subphylum Reticulofilosa (paraphyletic on site-heterogeneous trees) branches earliest, Granofilosea before Chlorarachnea. Our multiprotein trees confirm that Rhizaria are <span class="hlt">sisters</span> of infrakingdom Halvaria (Alveolata, Heterokonta) within chromist subkingdom Harosa (= SAR); they further support holophyly of chromist subkingdom Hacrobia</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17938080','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17938080"><span>Misclassified maternal <span class="hlt">deaths</span> among East African immigrants in Sweden.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Elebro, Karin; Rööst, Mattias; Moussa, Kontie; Johnsdotter, Sara; Essén, Birgitta</p> <p>2007-11-01</p> <p>Western countries have reported an increased risk of maternal mortality among African immigrants. This study aimed to identify cases of maternal mortality among immigrants from the Horn of Africa living in Sweden using snowball sampling, and verify whether they had been classified as maternal <span class="hlt">deaths</span> in the Cause of <span class="hlt">Death</span> Registry. Three "locators" contacted immigrants from Somalia, Eritrea, and Ethiopia to identify possible cases of maternal mortality. Suspected <span class="hlt">deaths</span> were scrutinised through verbal autopsy and medical records. Confirmed instances, <span class="hlt">linked</span> by country of birth, were compared with Registry statistics. We identified seven possible maternal <span class="hlt">deaths</span> of which four were confirmed in medical records, yet only one case had been classified as such in the Cause of <span class="hlt">Death</span> Registry. At least two cases, a significant number, seemed to be misclassified. The challenges of both cultural and medical competence for European midwives and obstetricians caring for non-European immigrant mothers should be given more attention, and the chain of information regarding maternal <span class="hlt">deaths</span> should be strengthened. We propose a practice similar to the British confidential enquiry into maternal <span class="hlt">deaths</span>. In Sweden, snowball sampling was valuable for contacting immigrant communities for research on maternal mortality; by strengthening statistical validity, it can contribute to better maternal health policy in a multi-ethnic society.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29352268','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29352268"><span>Cylindromatosis mediates neuronal cell <span class="hlt">death</span> in vitro and in vivo.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ganjam, Goutham K; Terpolilli, Nicole Angela; Diemert, Sebastian; Eisenbach, Ina; Hoffmann, Lena; Reuther, Christina; Herden, Christiane; Roth, Joachim; Plesnila, Nikolaus; Culmsee, Carsten</p> <p>2018-01-19</p> <p>The tumor-suppressor cylindromatosis (CYLD) is a deubiquitinating enzyme and key regulator of cell proliferation and inflammation. A genome-wide siRNA screen <span class="hlt">linked</span> CYLD to receptor interacting protein-1 (RIP1) kinase-mediated necroptosis; however, the exact mechanisms of CYLD-mediated cell <span class="hlt">death</span> remain unknown. Therefore, we investigated the precise role of CYLD in models of neuronal cell <span class="hlt">death</span> in vitro and evaluated whether CYLD deletion affects brain injury in vivo. In vitro, downregulation of CYLD increased RIP1 ubiquitination, prevented RIP1/RIP3 complex formation, and protected neuronal cells from oxidative <span class="hlt">death</span>. Similar protective effects were achieved by siRNA silencing of RIP1 or RIP3 or by pharmacological inhibition of RIP1 with necrostatin-1. In vivo, CYLD knockout mice were protected from trauma-induced brain damage compared to wild-type littermate controls. These findings unravel the mechanisms of CYLD-mediated cell <span class="hlt">death</span> signaling in damaged neurons in vitro and suggest a cell <span class="hlt">death</span>-mediating role of CYLD in vivo.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ghr.nlm.nih.gov/condition/x-linked-cardiac-valvular-dysplasia','NIH-MEDLINEPLUS'); return false;" href="https://ghr.nlm.nih.gov/condition/x-linked-cardiac-valvular-dysplasia"><span>Genetics Home Reference: X-<span class="hlt">linked</span> cardiac valvular dysplasia</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... inflammation of the inner lining of the heart (endocarditis), abnormal blood clots, or sudden <span class="hlt">death</span>. X-<span class="hlt">linked</span> ... Johns Hopkins Medicine: Mitral Valve Prolapse MedlinePlus Encyclopedia: Endocarditis MedlinePlus Encyclopedia: Mitral Valve Prolapse General Information from ...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_14 --> <div id="page_15" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="281"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16402872','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16402872"><span>Longitudinal pathways <span class="hlt">linking</span> family factors and sibling relationship qualities to adolescent substance use and sexual risk behaviors.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>East, Patricia L; Khoo, Siek Toon</p> <p>2005-12-01</p> <p>This 3-wave, 5-year longitudinal study tested the contributions of family contextual factors and sibling relationship qualities to younger siblings' substance use, sexual risk behaviors, pregnancy, and sexually transmitted disease. More than 220 non-White families participated (67% Latino and 33% African American), all of which involved a younger sibling (133 girls and 89 boys; mean age = 13.6 years at Time 1) and an older <span class="hlt">sister</span> (mean age = 17 years at Time 1). Results from structural equation latent growth curve modeling indicated that qualities of the sibling relationship (high older <span class="hlt">sister</span> power, low warmth/closeness, and low conflict) mediated effects from several family risks (mothers' single parenting, older <span class="hlt">sisters</span>' teen parenting, and family's receipt of aid) to younger sibling outcomes. Model results were generally stronger for <span class="hlt">sister-sister</span> pairs than for <span class="hlt">sister</span>-brother pairs. Findings add to theoretical models that emphasize the role of family and parenting processes in shaping sibling relationships, which, in turn, influence adolescent outcomes. Copyright 2006 APA, all rights reserved).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/14577741','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/14577741"><span>Temporal correlation between opiate seizures in East/Southeast Asia and B.C. heroin <span class="hlt">deaths</span>: a transoceanic model of heroin <span class="hlt">death</span> risk.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McLean, Mark E</p> <p>2003-01-01</p> <p>Because heroin supply changes cannot be measured directly, their impact on populations is poorly understood. British Columbia has experienced an injection drug use epidemic since the 1980s that resulted in 2,590 illicit drug <span class="hlt">deaths</span> from 1990-1999. Since previous work indicates heroin seizures can correlate with supply and B.C. receives heroin only from Southeast Asia, this study examined B.C. heroin <span class="hlt">deaths</span> against opiate seizures in East/Southeast Asia. Opiate seizures in East/Southeast Asia and data from two B.C. mortality datasets containing heroin <span class="hlt">deaths</span> were examined. The Pearson correlation coefficient for seizures against each mortality dataset was determined. Opiate seizures, all illicit drug <span class="hlt">deaths</span> and all opiate <span class="hlt">deaths</span> concurrently increased twice and decreased twice from 1989-1999, and all reached new peak values in 1993. Three B.C. sub-regions exhibited illicit drug <span class="hlt">deaths</span> rate trends concurrent with the three principal datasets studied. The Pearson correlation coefficient for opiate-induced <span class="hlt">deaths</span> against opiate seizures from 1980-1999 was R=0.915 (p<0.0001), and for illicit drug <span class="hlt">deaths</span> against opiate seizures from 1987-1999 was R=0.896 (p<0.0001). From 1980-1999, opiate seizures in East/Southeast Asia were very strongly correlated with B.C. opiate and illicit drug <span class="hlt">deaths</span>. The number of B.C. heroin-related <span class="hlt">deaths</span> may be strongly <span class="hlt">linked</span> to heroin supply. Enforcement services are not effective in preventing harm caused by heroin in B.C.; therefore, Canada should examine other methods to prevent harm. The case for harm reduction is strengthened by the ineffectiveness of enforcement and the unlikelihood of imminent eradication of heroin production in Southeast Asia.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20170009934','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20170009934"><span>Basalt Weathering in a Cold and Icy Climate: Three <span class="hlt">Sisters</span>, Oregon as an Analog for Early Mars</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Rampe, E. B.; Horgan, B.; Smith, R. J.; Scudder, N. A.; Rutledge, A. M.; Bamber, E.; Morris, R. V.</p> <p>2017-01-01</p> <p>There is abundant evidence for liquid water on early Mars, but the debate remains whether early Mars was warm and wet or cold and icy with punctuated periods of melting. To further investigate the hypothesis of a cold and icy early Mars, we collected rocks and sediments from the Collier and Diller glacial valleys in the Three <span class="hlt">Sisters</span> volcanic complex in Oregon. We analyzed rocks and sediments with X-ray diffraction (XRD), scanning and transmission electron microscopies with energy dispersive spectroscopy (SEM, TEM, EDS), and visible, short-wave infrared (VSWIR) and thermal-IR (TIR) spectroscopies to characterize chemical weathering and sediment transport through the valleys. Here, we focus on the composition and mineralogy of the weathering products and how they compare to those identified on the martian surface. Phyllosilicates (smectite), zeolites, and poorly crystalline phases were discovered in pro- and supra-glacial sediments, whereas Si-rich regelation films were found on hand samples and boulders in the proglacial valleys. Most phyllosilicates and zeolites are likely detrital, originating from hydrothermally altered units on North <span class="hlt">Sister</span>. TEM-EDS analyses of the <2 um size fraction of glacial flour samples demonstrate a variety of poorly crystalline (i.e., no long-range crystallographic order) phases: iron oxides, devitrified volcanic glass, and Fe-Si-Al phases. The CheMin XRD on the Curiosity rover in Gale crater has identified significant amounts of X-ray amorphous materials in all samples measured to date. The amorphous component is likely a combination of silicates, iron oxides, and sulfates. Although we have not yet observed amorphous sulfate in the samples from Three <span class="hlt">Sisters</span>, the variety of poorly crystalline weathering products found at this site is consistent with the variable composition of the X-ray amorphous component identified by CheMin. We suggest that these amorphous phases on Mars could have formed in a similarly cold and icy environment.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1216365','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1216365"><span>Lack of Spontaneous <span class="hlt">Sister</span> Chromatid Exchanges in Somatic Cells of DROSOPHILA MELANOGASTER</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gatti, M.; Santini, G.; Pimpinelli, S.; Olivieri, G.</p> <p>1979-01-01</p> <p>Neural ganglia of wild type third-instar larvae of Drosophila melanogaster were incubated for 13 hours at various concentrations of BUdR (1, 3, 9, 27 µg/ml). Metaphases were collected with colchicine, stained with Hoechst 33258, and scored under a fluorescence microscope. Metaphases in which the <span class="hlt">sister</span> chromatids were clearly differentiated were scored for the presence of <span class="hlt">sister</span>-chromatid exchanges (SCEs). At the lowest concentration of BUdR (1 µg/ml), no SCEs were observed in either male or female neuroblasts. The SCEs were found at the higher concentrations of BUdR (3, 9 and 27 µg/ml) and with a greater frequency in females than in males. Therefore SCEs are not a spontaneous phenomenon in D. melanogaster, but are induced by BUdR incorporated in the DNA. A striking nonrandomness was found in the distribution of SCEs along the chromosomes. More than a third of the SCEs were clustered in the junctions between euchromatin and heterochromatin. The remaining SCEs were preferentially localized within the heterochromatic regions of the X chromosome and the autosomes and primarily on the entirely heterochromatic Y chromosome.—In order to find an alternative way of measuring the frequency of SCEs in Drosophila neuroblasts, the occurrence of double dicentric rings was studied in two stocks carrying monocentric ring-X chromosomes. One ring chromosome, C(1)TR 94–2, shows a rate of dicentric ring formation corresponding to the frequency of SCEs observed in the BUdR-labelled rod chromosomes. The other ring studied, R(1)2, exhibits a frequency of SCEs higher than that observed with both C(1)TR 94–2 and rod chromosomes. PMID:109350</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1372773','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1372773"><span>EPRI/DOE High Burnup Fuel <span class="hlt">Sister</span> Pin Test Plan Simplification and Visualization</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Saltzstein, Sylvia J.; Sorenson, Ken B.; Hanson, Brady</p> <p></p> <p>The EPRI/DOE High Burnup Confirmatory Data Project (herein called the "Demo") is a multi-year, multi-entity confirmation demonstration test with the purpose of providing quantitative and qualitative data to show how high-burnup fuel ages in dry storage over a ten-year period. The Demo involves obtaining 32 assemblies of high-burnup PWR fuel of four common cladding alloys from the North Anna Nuclear Power Plant, drying them according to standard plant procedures, and then storing them in an NRC-licensed TN-3 2B cask on the North Anna dry storage pad for ten years. After the ten-year storage time, the cask will be opened andmore » the rods will be examined for signs of aging. Twenty-five rods from assemblies of similar claddings, in-reactor placement, and burnup histories (herein called "<span class="hlt">sister</span> rods") have been shipped from the North Anna Nuclear Power Plant and are currently being nondestructively tested at Oak Ridge National Laboratory. After the non-destructive testing has been completed for each of the twenty-five rods, destructive analysis will be performed at ORNL, PNNL, and ANL to obtain mechanical data. Opinions gathered from the expert interviews, ORNL and PNNL <span class="hlt">Sister</span> Rod Test Plans, and numerous meetings has resulted in the Simplified Test Plan described in this document. Some of the opinions and discussions leading to the simplified test plan are included here. Detailed descriptions and background are in the ORNL and PNNL plans in the appendices . After the testing described in this simplified test plan h as been completed , the community will review all the collected data and determine if additional testing is needed.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29927056','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29927056"><span>WNT10A mutation results in severe tooth agenesis in a family of three <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Abid, M F; Simpson, M A; Barbosa, I A; Seppala, M; Irving, M; Sharpe, P T; Cobourne, M T</p> <p>2018-06-21</p> <p>To identify the genetic basis of severe tooth agenesis in a family of three affected <span class="hlt">sisters</span>. A family of three <span class="hlt">sisters</span> with severe tooth agenesis was recruited for whole-exome sequencing to identify potential genetic variation responsible for this penetrant phenotype. The unaffected father was tested for specific mutations using Sanger sequencing. Gene discovery was supplemented with in situ hybridization to localize gene expression during human tooth development. We report a nonsense heterozygous mutation in exon 2 of WNT10A c.321C>A[p.Cys107*] likely to be responsible for the severe tooth agenesis identified in this family through the creation of a premature stop codon, resulting in truncation of the amino acid sequence and therefore loss of protein function. In situ hybridization showed expression of WNT10A in odontogenic epithelium during the early and late stages of human primary tooth development. WNT10A has previously been associated with both syndromic and non-syndromic forms of tooth agenesis, and this report further expands our knowledge of genetic variation underlying non-syndromic forms of this condition. We also demonstrate expression of WNT10A in the epithelial compartment of human tooth germs during development. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28095054','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28095054"><span>Adolescent Siblings of Individuals With and Without Intellectual and Developmental Disabilities: Self-Reported Empathy and Feelings About Their Brothers and <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shivers, Carolyn M; Dykens, Elisabeth M</p> <p>2017-01-01</p> <p>Siblings of brothers or <span class="hlt">sisters</span> with intellectual and developmental disabilities (IDD) are important but understudied family members. As many previous studies have relied on parent report of sibling outcomes, the use of sibling self-report is an important addition to the research. This study assessed the feelings of adolescent siblings toward their brothers or <span class="hlt">sisters</span> with and without IDD, as well as broader aspects of sibling empathy. Data were collected via a national, online survey from 97 parent-sibling pairs. Siblings of individuals with IDD reported higher levels of anxiety toward the target child than did siblings of typically developing individuals. Sibling feelings toward the target child were related to both parental and target child factors, but only among families of individuals with IDD.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4580085','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4580085"><span>Caspase-9 Mediates Photoreceptor <span class="hlt">Death</span> After Blunt Ocular Trauma</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Blanch, Richard J.; Ahmed, Zubair; Thompson, Adam R.; Akpan, Nsikan; Snead, David R. J.; Berry, Martin; Troy, Carol M.; Scott, Robert A. H.; Logan, Ann</p> <p>2014-01-01</p> <p>Purpose. Ocular trauma is common in civilian and military populations. Commotio retinae involves acute disruption of photoreceptor outer segments after blunt ocular trauma, with subsequent photoreceptor apoptosis causing permanent visual impairment. The mechanisms of photoreceptor <span class="hlt">death</span> in commotio retinae have not previously been described, although caspase-dependent <span class="hlt">death</span> is important in other nontraumatic retinal degenerations. We assessed the role of caspase-9 as a mediator of photoreceptor <span class="hlt">death</span> in a rat model of ballistic ocular trauma causing commotio retinae. Methods. Bilateral commotio retinae was induced in rats by ballistic ocular trauma. Caspase-9 activity was assessed by immunohistochemistry, Western blotting, and bVAD-fmk active caspase capture. Caspase-9 was inhibited by unilateral intravitreal injection of highly specific X-<span class="hlt">linked</span> inhibitor of apoptosis (IAP) baculoviral IAP repeat 3 (XBIR3) domain <span class="hlt">linked</span> to the cell transduction peptide penetratin 1 (Pen-1) after ballistic injury, and the affected eyes were compared with control eyes treated with Pen-1 injection alone, and retinal function was assessed by electroretinogram a-wave amplitude and photoreceptor survival by outer nuclear layer thickness. Results. Increased levels of cleaved caspase-9 were shown in photoreceptors 5 hours after injury, and catalytically active full-length caspase-9 was isolated from retinas. Photoreceptor <span class="hlt">death</span> after commotio retinae was reduced by caspase-9 inhibition by using Pen-1–XBIR3, and electroretinographic measurements of photoreceptor function was preserved, providing structural and functional neuroprotection. Conclusions. The time course of caspase-9 activation and the neuroprotective effects of inhibition suggest that caspase-9 initiates cell <span class="hlt">death</span> in a proportion of photoreceptors after blunt ocular trauma and that an intravitreally delivered biologic inhibitor may be an effective translational treatment strategy. PMID:25190658</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=food+AND+category&pg=6&id=EJ825688','ERIC'); return false;" href="https://eric.ed.gov/?q=food+AND+category&pg=6&id=EJ825688"><span>Dietary Behaviors and Portion Sizes of Black Women Who Enrolled in "<span class="hlt">Sister</span>Talk" and Variation by Demographic Characteristics</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Gans, Kim M.; Risica, Patricia Markham; Kirtania, Usree; Jennings, Alishia; Strolla, Leslie O.; Steiner-Asiedu, Matilda; Hardy, Norma; Lasater, Thomas M.</p> <p>2009-01-01</p> <p>Objective: To describe the dietary behaviors of black women who enrolled in the <span class="hlt">Sister</span>Talk weight control study. Design: Baseline data collected via telephone survey and in-person screening. Setting: Boston, Massachusetts and surrounding areas. Participants: 461 black women completed the baseline assessments. Main Outcome Measures: Measured height…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15262265','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15262265"><span>Zinc release contributes to hypoglycemia-induced neuronal <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Suh, Sang Won; Garnier, Philippe; Aoyama, Koji; Chen, Yongmei; Swanson, Raymond A</p> <p>2004-08-01</p> <p>Neurons exposed to zinc exhibit activation of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme that normally participates in DNA repair but promotes cell <span class="hlt">death</span> when extensively activated. Endogenous, vesicular zinc in brain is released to the extracellular space under conditions causing neuronal depolarization. Here, we used a rat model of insulin-induced hypoglycemia to assess the role of zinc release in PARP-1 activation and neuronal <span class="hlt">death</span> after severe hypoglycemia. Zinc staining with N-(6-methoxy-8-quinolyl)-para-toluenesulfonamide (TSQ) showed depletion of presynaptic vesicular zinc from hippocampal mossy fiber terminals and accumulation of weakly bound zinc in hippocampal CA1 cell bodies after severe hypoglycemia. Intracerebroventricular injection of the zinc chelator calcium ethylene-diamine tetraacetic acid (CaEDTA) blocked the zinc accumulation and significantly reduced hypoglycemia-induced neuronal <span class="hlt">death</span>. CaEDTA also attenuated the accumulation of poly(ADP-ribose), the enzymatic product of PARP-1, in hippocampal neurons. These results suggest that zinc translocation is an intermediary step <span class="hlt">linking</span> hypoglycemia to PARP-1 activation and neuronal <span class="hlt">death</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29801950','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29801950"><span>Causes of <span class="hlt">deaths</span> data, linkages and big data perspectives.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rey, Grégoire; Bounebache, Karim; Rondet, Claire</p> <p>2018-07-01</p> <p>The study of cause-specific mortality data is one of the main sources of information for public health monitoring. In most industrialized countries, when a <span class="hlt">death</span> occurs, it is a legal requirement that a medical certificate based on the international form recommended by World Health Organization's (WHO) is filled in by a physician. The physician reports the causes of <span class="hlt">death</span> that directly led or contributed to the <span class="hlt">death</span> on the <span class="hlt">death</span> certificate. The <span class="hlt">death</span> certificate is then forwarded to a coding office, where each cause is coded, and one underlying cause is defined, using the rules of the International Classification of Diseases and Related Health Problems, now in its 10th Revision (ICD-10). Recently, a growing number of countries have adopted, or have decided to adopt, the coding software Iris, developed and maintained by an international consortium 1 . This whole standardized production process results in a high and constantly increasing international comparability of cause-specific mortality data. While these data could be used for international comparisons and benchmarking of global burden of diseases, quality of care and prevention policies, there are also many other ways and methods to explore their richness, especially when they are <span class="hlt">linked</span> with other data sources. Some of these methods are potentially referring to the so-called "big data" field. These methods could be applied both to the production of the data, to the statistical processing of the data, and even more to process these data <span class="hlt">linked</span> to other databases. In the present note, we depict the main domains in which this new field of methods could be applied. We focus specifically on the context of France, a 65 million inhabitants country with a centralized health data system. Finally we will insist on the importance of data quality, and the specific problematics related to <span class="hlt">death</span> certification in the forensic medicine domain. Copyright © 2016 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED513452.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED513452.pdf"><span>Untapped Potential: Fulfilling the Promise of Big Brothers Big <span class="hlt">Sisters</span> and the Bigs and Littles They Represent</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bridgeland, John M.; Moore, Laura A.</p> <p>2010-01-01</p> <p>American children represent a great untapped potential in our country. For many young people, choices are limited and the goal of a productive adulthood is a remote one. This report paints a picture of who these children are, shares their insights and reflections about the barriers they face, and offers ways forward for Big Brothers Big <span class="hlt">Sisters</span> as…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Herrera&pg=3&id=ED503112','ERIC'); return false;" href="https://eric.ed.gov/?q=Herrera&pg=3&id=ED503112"><span>High School Students as Mentors: Findings from the Big Brothers Big <span class="hlt">Sisters</span> School-Based Mentoring Impact Study</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Herrera, Carla; Kauh, Tina J.; Cooney, Siobhan M.; Grossman, Jean Baldwin; McMaken, Jennifer</p> <p>2008-01-01</p> <p>High schools have recently become a popular source of mentors for school-based mentoring (SBM) programs. The high school Bigs program of Big Brothers Big <span class="hlt">Sisters</span> of America, for example, currently involves close to 50,000 high-school-aged mentors across the country. While the use of these young mentors has several potential advantages, their age…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-11-07/pdf/2012-27237.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-11-07/pdf/2012-27237.pdf"><span>77 FR 66851 - Submission for OMB Review; Comment Request The <span class="hlt">Sister</span> Study: A Prospective Study of the Genetic...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-11-07</p> <p>... Breast Cancer SUMMARY: Under the provisions of Section 3507(a)(1)(D) of the Paperwork Reduction Act of... Environmental Risk Factors for Breast Cancer. Type of Information Collection Request: Revision. Need and Use of... and environmental risk factors for the development of breast cancer in a high-risk cohort of <span class="hlt">sisters</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=death&pg=5&id=EJ929126','ERIC'); return false;" href="https://eric.ed.gov/?q=death&pg=5&id=EJ929126"><span>Time Does Not Heal All Wounds: Mortality following the <span class="hlt">Death</span> of a Parent</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rostila, Mikael; Saarela, Jan M.</p> <p>2011-01-01</p> <p>People <span class="hlt">linked</span> through social ties are known to have interdependent health. Our aim was to investigate such collateral health effects in the context of offspring mortality after a parent's <span class="hlt">death</span> in children aged 10-59 years. The data (N = 3,753,368) were from a <span class="hlt">linked</span>-registers database that contains the total Swedish population. In minor children,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=39928&Lab=ORD&keyword=infusion&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50','EPA-EIMS'); return false;" href="https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=39928&Lab=ORD&keyword=infusion&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50"><span>INDUCTION, ACCUMULATION, AND PERSISTENCE OF <span class="hlt">SISTER</span> CHROMATID EXCHANGES IN WOMEN WITH BREAST CANCER RECEIVING CYCLOPHOSPHAMIDE, ANDRIAMYCIN, AND 5-FLUOROACIL CHEMOTHERAPY</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>The induction, stimulation, and persistence of <span class="hlt">sister</span> chromatid exchanges (SCE's) and high SCE frequency cells (HFC's) was measured in peripheral lymphocytes of women with breast cancer before chemotherapy and on multiple occasions during and after therapy. Chemotherapy consisted...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/3389175','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/3389175"><span>The development of antisocial behaviour and sudden violent <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rydelius, P A</p> <p>1988-04-01</p> <p>In order to detect possible relationships between antisocial behaviour and the incidence of "sudden violent <span class="hlt">death</span>" in young people, information relating to mortality in antisocial Swedish adolescents has been traced and compiled. A register was drawn up covering those young persons (1,056; 832 boys and 224 girls; mean age 16 years) who were admitted to Swedish probationary schools during the period 1 January - 31 December 1967. Using the registers of immigration and emigration, and causes of <span class="hlt">death</span> kept by SCB (Statistiska Centralbyrån), mortality occurring between 1 January 1967 - 31 December 1985 was tabulated. One hundred and ten boys (13%) and 22 girls (10%) had died. The <span class="hlt">deaths</span> had occurred at a rate of approximately seven new <span class="hlt">deaths</span> per observation year, the youngest being still in their teens when they died. For comparison, the criteria set up by insurance companies for life insurance premiums are based on a <span class="hlt">death</span> expectancy for healthy Swedish boys and girls in the age groups corresponding to the subjects under observation of 1.2-3.1% for boys and 1.1-2.6% for girls. Eighty-eight percent of the dead boys and 77% of the dead girls had died "sudden violent <span class="hlt">deaths</span>" - accidents, suicides, <span class="hlt">death</span> from uncertain causes, murder/manslaughter, or alcohol/drug abuse. For both sexes, <span class="hlt">death</span> from uncertain causes and suicides were the most frequent single causes of <span class="hlt">death</span>. <span class="hlt">Death</span> as a direct result of alcohol/drug abuse occurred only in boys. The results give support to the assumption that a <span class="hlt">link</span> exists between childhood environment, the development of antisocial behaviour/mental insufficiency and a "sudden violent <span class="hlt">death</span>" at an early age.(ABSTRACT TRUNCATED AT 250 WORDS)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=241184','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=241184"><span>Phylogenetic analysis of seven WRKY genes across the palm subtribe Attaleinae (Areceaceae) identifies Syagrus as <span class="hlt">sister</span> to the coconut</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>The origins of the coconut (Cocos nucifera) have been one of the "abominable mysteries" of palm systematics for decades. Previous studies with predominantly plastid genes have indicated an American ancestry for the coconut but with weak support and ambiguous <span class="hlt">sister</span> relationships. We used primers d...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=death+AND+penalty&pg=4&id=EJ387980','ERIC'); return false;" href="https://eric.ed.gov/?q=death+AND+penalty&pg=4&id=EJ387980"><span>Structured Discretion, Racial Bias, and the <span class="hlt">Death</span> Penalty: The First Decade after "Furman" in Texas.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Ekland-Olson, Sheldon</p> <p>1988-01-01</p> <p>Analyzes data collected in Texas from the first decade of cases sentenced to <span class="hlt">death</span> after the Furman v. Georgia decision in order to determine any tendency toward being race-<span class="hlt">linked</span> or victim-based. Found that cases involving White victims more often precipitate the <span class="hlt">death</span> penalty than those involving Black or Hispanic victims. (KO)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12120831','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12120831"><span>Residential fire related <span class="hlt">deaths</span> and injuries among children: fireplay, smoke alarms, and prevention.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Istre, G R; McCoy, M; Carlin, D K; McClain, J</p> <p>2002-06-01</p> <p>The aim of the study was to describe the epidemiology of residential fire related <span class="hlt">deaths</span> and injuries among children, and identify risk factors for these injuries through a <span class="hlt">linked</span> dataset for the city of Dallas, Texas. Data for all residential fires were <span class="hlt">linked</span> with fire related injury data, using fire department records, ambulance transports, hospital admissions, and medical examiner records, for children 0-19 years of age. Causes of fires, including fireplay (children playing with fire or combustibles), arson and other causes, were determined by fire department investigation. From 1991-98, 76 children were injured in residential fires (39 <span class="hlt">deaths</span>, 37 non-fatal). The highest rates occurred in the youngest children (<5 years) and in census tracts with lowest income. Fireplay accounted for 42% (32/76) of all injuries, 62% (15/24) of <span class="hlt">deaths</span> in children 0-4 years, and 94% (13/14) of <span class="hlt">deaths</span> from apartment and mobile home fires. Most of the fireplay related injuries (27/32, 84%) were from children playing with matches or lighters. Most started in a bedroom. Smoke alarms showed no protective efficacy in preventing <span class="hlt">deaths</span> or injuries in fires started by fireplay or arson, but there was significant protective efficacy for a functional smoke alarm in fires started from all other causes (p<0.01). Residential fire related injuries among children in Dallas occurred predominantly in the youngest ages (<5 years) and in poor neighborhoods. Most of the <span class="hlt">deaths</span>, especially those in apartments and mobile homes, resulted from fireplay. Smoke alarms appeared to offer no protection against <span class="hlt">death</span> or injury in fireplay associated fires, possibly from the nature of the child's behavior in these fires, or from the placement of the smoke alarm. Prevention of childhood residential fire related <span class="hlt">deaths</span> may require interventions to prevent fireplay in order to be successful.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_15 --> <div id="page_16" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="301"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1730859','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1730859"><span>Residential fire related <span class="hlt">deaths</span> and injuries among children: fireplay, smoke alarms, and prevention</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Istre, G; McCoy, M; Carlin, D; McClain, J</p> <p>2002-01-01</p> <p>Background: The aim of the study was to describe the epidemiology of residential fire related <span class="hlt">deaths</span> and injuries among children, and identify risk factors for these injuries through a <span class="hlt">linked</span> dataset for the city of Dallas, Texas. Methods: Data for all residential fires were <span class="hlt">linked</span> with fire related injury data, using fire department records, ambulance transports, hospital admissions, and medical examiner records, for children 0–19 years of age. Causes of fires, including fireplay (children playing with fire or combustibles), arson and other causes, were determined by fire department investigation. Results: From 1991–98, 76 children were injured in residential fires (39 <span class="hlt">deaths</span>, 37 non-fatal). The highest rates occurred in the youngest children (<5 years) and in census tracts with lowest income. Fireplay accounted for 42% (32/76) of all injuries, 62% (15/24) of <span class="hlt">deaths</span> in children 0–4 years, and 94% (13/14) of <span class="hlt">deaths</span> from apartment and mobile home fires. Most of the fireplay related injuries (27/32, 84%) were from children playing with matches or lighters. Most started in a bedroom. Smoke alarms showed no protective efficacy in preventing <span class="hlt">deaths</span> or injuries in fires started by fireplay or arson, but there was significant protective efficacy for a functional smoke alarm in fires started from all other causes (p<0.01). Conclusions: Residential fire related injuries among children in Dallas occurred predominantly in the youngest ages (<5 years) and in poor neighborhoods. Most of the <span class="hlt">deaths</span>, especially those in apartments and mobile homes, resulted from fireplay. Smoke alarms appeared to offer no protection against <span class="hlt">death</span> or injury in fireplay associated fires, possibly from the nature of the child's behavior in these fires, or from the placement of the smoke alarm. Prevention of childhood residential fire related <span class="hlt">deaths</span> may require interventions to prevent fireplay in order to be successful. PMID:12120831</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26718549','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26718549"><span>The National Violent <span class="hlt">Death</span> Reporting System: overview and future directions.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Blair, Janet M; Fowler, Katherine A; Jack, Shane P D; Crosby, Alexander E</p> <p>2016-04-01</p> <p>To describe the National Violent <span class="hlt">Death</span> Reporting System (NVDRS). This is a surveillance system for monitoring the occurrence of homicides, suicides, unintentional firearm <span class="hlt">deaths</span>, <span class="hlt">deaths</span> of undetermined intent, and <span class="hlt">deaths</span> from legal intervention (excluding legal executions) in the US. This report provides information about the history, scope, data variables, processes, utility, limitations, and future directions of the NVDRS. The NVDRS currently operates in 32 states, with the goal of future expansion to all 50 states, the District of Columbia, and US territories. The system uses existing primary data sources (<span class="hlt">death</span> certificates, coroner/medical examiner reports, and law enforcement reports), and <span class="hlt">links</span> them together to provide a comprehensive picture of the circumstances surrounding violent <span class="hlt">deaths</span>. This report provides an overview of the NVDRS including a description of the system, discussion of its expanded capability, the use of new technologies as the system has evolved, how the data are being used for violence prevention efforts, and future directions. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29242248','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29242248"><span>Causes of <span class="hlt">Death</span> after a Hospitalization with AKI.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Silver, Samuel A; Harel, Ziv; McArthur, Eric; Nash, Danielle M; Acedillo, Rey; Kitchlu, Abhijat; Garg, Amit X; Chertow, Glenn M; Bell, Chaim M; Wald, Ron</p> <p>2018-03-01</p> <p>Mortality after AKI is high, but the causes of <span class="hlt">death</span> are not well described. To better understand causes of <span class="hlt">death</span> in patients after a hospitalization with AKI and to determine patient and hospital factors associated with mortality, we conducted a population-based study of residents in Ontario, Canada, who survived a hospitalization with AKI from 2003 to 2013. Using <span class="hlt">linked</span> administrative databases, we categorized cause of <span class="hlt">death</span> in the year after hospital discharge as cardiovascular, cancer, infection-related, or other. We calculated standardized mortality ratios to compare the causes of <span class="hlt">death</span> in survivors of AKI with those in the general adult population and used Cox proportional hazards modeling to estimate determinants of <span class="hlt">death</span>. Of the 156,690 patients included, 43,422 (28%) died in the subsequent year. The most common causes of <span class="hlt">death</span> were cardiovascular disease (28%) and cancer (28%), with respective standardized mortality ratios nearly six-fold (5.81; 95% confidence interval [95% CI], 5.70 to 5.92) and eight-fold (7.87; 95% CI, 7.72 to 8.02) higher than those in the general population. The highest standardized mortality ratios were for bladder cancer (18.24; 95% CI, 17.10 to 19.41), gynecologic cancer (16.83; 95% CI, 15.63 to 18.07), and leukemia (14.99; 95% CI, 14.16 to 15.85). Along with older age and nursing home residence, cancer and chemotherapy strongly associated with 1-year mortality. In conclusion, cancer-related <span class="hlt">death</span> was as common as cardiovascular <span class="hlt">death</span> in these patients; moreover, cancer-related <span class="hlt">deaths</span> occurred at substantially higher rates than in the general population. Strategies are needed to care for and counsel patients with cancer who experience AKI. Copyright © 2018 by the American Society of Nephrology.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www1.nichd.nih.gov/publications/pubs/Documents/Safe_Sleep_Baby_English.pdf','NIH-MEDLINEPLUS'); return false;" href="https://www1.nichd.nih.gov/publications/pubs/Documents/Safe_Sleep_Baby_English.pdf"><span>Safe Sleep for Your Baby: Reduce the Risk of SIDS and Other Sleep-Related Causes of Infant <span class="hlt">Death</span></span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... Fast facts about SIDS: SIDS is the leading cause of <span class="hlt">death</span> in babies 1 month to 1 year of ... baby to die suddenly and unexpectedly. Sleep-related causes of infant <span class="hlt">death</span> are those <span class="hlt">linked</span> to how or where a ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4775908','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4775908"><span>Mitochondrial Genes Reveal Triatoma jatai as a <span class="hlt">Sister</span> Species to Triatoma costalimai (Reduviidae: Triatominae)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Teves, Simone Caldas; Gardim, Sueli; Carbajal de la Fuente, Ana Laura; Lopes, Catarina Macedo; Gonçalves, Teresa Cristina Monte; Mallet, Jacenir Reis dos Santos; da Rosa, João Aristeu; Almeida, Carlos Eduardo</p> <p>2016-01-01</p> <p>Triatoma jatai was described using a set of morphological structures from specimens collected in Paranã municipality of Tocantins State, Brazil. Under a Bayesian framework and using two mitochondrial genes (16S and COI), phylogenetic analysis recovered T. jatai as a <span class="hlt">sister</span> species to Triatoma costalimai with higher genetic distances than between other well-recognized species. Our results agree with previous suggestions based on morphometric analysis. In the light of the non-monophyly of Matogrossensis subcomplex, the inclusion of T. jatai shall be considered for reevaluating this group. PMID:26787157</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16882800','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16882800"><span>Air pollution and infant <span class="hlt">death</span> in southern California, 1989-2000.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ritz, Beate; Wilhelm, Michelle; Zhao, Yingxu</p> <p>2006-08-01</p> <p>We evaluated the influence of outdoor air pollution on infant <span class="hlt">death</span> in the South Coast Air Basin of California, an area characterized by some of the worst air quality in the United States. <span class="hlt">Linking</span> birth and <span class="hlt">death</span> certificates for infants who died between 1989 and 2000, we identified all infant <span class="hlt">deaths</span>, matched 10 living control subjects to each case subject, and assigned the nearest air monitoring station to each birth address. For all subjects, we calculated average carbon monoxide, nitrogen dioxide, ozone, and particulate matter < 10 microm in aerodynamic diameter exposures experienced during the 2-week, 1-month, 2-month, and 6-month periods before a case subject's <span class="hlt">death</span>. The risk of respiratory <span class="hlt">death</span> increased from 20% to 36% per 1-ppm increase in average carbon monoxide levels 2 weeks before <span class="hlt">death</span> in early infancy (age: 28 days to 3 months). We also estimated 7% to 12% risk increases for respiratory <span class="hlt">deaths</span> per 10-microg/m3 increase in particulate matter < 10 microm in aerodynamic diameter exposure experienced 2 weeks before <span class="hlt">death</span> for infants 4 to 12 months of age. Risk of respiratory <span class="hlt">death</span> more than doubled for infants 7 to 12 months of age who were exposed to high average levels of particulates in the previous 6 months. Furthermore, the risk of dying as a result of sudden infant <span class="hlt">death</span> syndrome increased 15% to 19% per 1-part per hundred million increase in average nitrogen dioxide levels 2 months before <span class="hlt">death</span>. Low birth weight and preterm infants seemed to be more susceptible to air pollution-related <span class="hlt">death</span> resulting from these causes; however, we lacked statistical power to confirm this heterogeneity with formal testing. Our results add to the growing body of literature implicating air pollution in infant <span class="hlt">death</span> from respiratory causes and sudden infant <span class="hlt">death</span> syndrome and provide additional information for future risk assessment.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22415350','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22415350"><span>Novel insertion in exon 5 of the TCOF1 gene in twin <span class="hlt">sisters</span> with Treacher Collins syndrome.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Marszałek-Kruk, Bożena Anna; Wójcicki, Piotr; Smigiel, Robert; Trzeciak, Wiesław H</p> <p>2012-08-01</p> <p>Treacher Collins syndrome (TCS) is associated with an abnormal differentiation of the first and second pharyngeal arches during fetal development. This causes mostly craniofacial deformities, which require numerous corrective surgeries. TCS is an autosomal dominant disorder and it occurs in the general population at a frequency of 1 in 50,000 live births. The syndrome is caused by mutations in the TCOF1 gene, which encodes the serine/alanine-rich protein named Treacle. Over 120 mutations of the TCOF1 gene responsible for TCS have been described. About 70% of recognized mutations are deletions, which lead to a frame shift, formation of a termination codon, and shortening of the protein product of the gene. Herewith, a new heterozygotic insertion, c.484_668ins185bp, was described in two monozygotic twin <span class="hlt">sisters</span> suffering from TCS. This mutation was absent in their father, brother, and uncle, indicating a de novo origin. The insertion causes a shift in the reading frame and premature termination of translation at 167 aa. The novel insertion is the longest ever found in the TCOF1 gene and the only one found among monozygotic twin <span class="hlt">sisters</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23681662','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23681662"><span>A CO-FISH assay to assess <span class="hlt">sister</span> chromatid segregation patterns in mitosis of mouse embryonic stem cells.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sauer, Stephan; Burkett, Sandra S; Lewandoski, Mark; Klar, Amar J S</p> <p>2013-05-01</p> <p><span class="hlt">Sister</span> chromatids contain identical DNA sequence but are chiral with respect to both their helical handedness and their replication history. Emerging evidence from various model organisms suggests that certain stem cells segregate <span class="hlt">sister</span> chromatids nonrandomly to either maintain genome integrity or to bias cellular differentiation in asymmetric cell divisions. Conventional methods for tracing of old vs. newly synthesized DNA strands generally lack resolution for individual chromosomes and employ halogenated thymidine analogs with profound cytotoxic effects on rapidly dividing cells. Here, we present a modified chromosome orientation fluorescence in situ hybridization (CO-FISH) assay, where identification of individual chromosomes and their replication history is achieved in subsequent hybridization steps with chromosome-specific DNA probes and PNA telomere probes. Importantly, we tackle the issue of BrdU cytotoxicity and show that our method is compatible with normal mouse ES cell biology, unlike a recently published related protocol. Results from our CO-FISH assay show that mitotic segregation of mouse chromosome 7 is random in ES cells, which contrasts previously published results from our laboratory and settles a controversy. Our straightforward protocol represents a useful resource for future studies on chromatid segregation patterns of in vitro-cultured cells from distinct model organisms.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29032024','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29032024"><span>Characteristics of self-inflicted drug overdose <span class="hlt">deaths</span> in North Carolina.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Austin, Anna E; Proescholdbell, Scott K; Creppage, Kathleen E; Asbun, Alex</p> <p>2017-12-01</p> <p>Drug overdose mortality is a major public health concern in the United States, with prescription opioids contributing substantially to recent increases in drug overdose <span class="hlt">deaths</span>. Compared to unintentional drug overdose <span class="hlt">deaths</span>, relatively little data describes intentional self-inflicted drug overdose <span class="hlt">deaths</span> (i.e., suicide by drug overdose). The aim of this study was to examine the characteristics of self-inflicted drug overdose <span class="hlt">deaths</span>, overall and in comparison to unintentional drug overdose <span class="hlt">deaths</span>. We <span class="hlt">linked</span> vital statistics, prescription drug monitoring program, and toxicology data for self-inflicted and unintentional drug overdose <span class="hlt">deaths</span> among North Carolina residents in 2012. Most self-inflicted (79.2%) and unintentional (75.6%) drug overdose decedents had a prescription for a controlled substance within one year of <span class="hlt">death</span>. Toxicology results revealed that antidepressants contributed to a significantly higher percent of self-inflicted compared to unintentional drug overdose <span class="hlt">deaths</span> (45.0% vs. 8.1%). Among <span class="hlt">deaths</span> in which commonly prescribed opioids (oxycodone, hydrocodone) or benzodiazepines (alprazolam, clonazepam) contributed to <span class="hlt">death</span>, a significantly higher percent of self-inflicted drug overdose decedents had a prescription for the substance within 30days of <span class="hlt">death</span> compared to unintentional drug overdose decedents. The results highlight the use of prescription opioids, benzodiazepines, and antidepressants among self-inflicted drug overdose decedents. Importantly, the results indicate that self-inflicted drug overdose decedents were more likely than unintentional drug overdose decedents to have potential contact with the health care system in the weeks preceding <span class="hlt">death</span>, offering an opportunity for professionals to identify and intervene on risk factors or signs of distress and potential for self-harm. Copyright © 2017 Elsevier B.V. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29590473','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29590473"><span>Disability Rating, Age at <span class="hlt">Death</span>, and Cause of <span class="hlt">Death</span> in U.S. Veterans with Service-Connected Conditions.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Maynard, Charles; Trivedi, Ranak; Nelson, Karin; Fihn, Stephan D</p> <p>2018-03-26</p> <p>The association between disability and cause of <span class="hlt">death</span> in Veterans with service-connected disabilities has not been studied. The objective of this study was to compare age at <span class="hlt">death</span>, military service and disability characteristics, including disability rating, and cause of <span class="hlt">death</span> by year of birth. We also examined cause of <span class="hlt">death</span> for specific service-connected conditions. This study used information from the VETSNET file, which is a snapshot of selected items from the Veterans Benefits Administration corporate database. We also used the National <span class="hlt">Death</span> Index (NDI) for Veterans which is part of the VA Suicide Data Repository. In VETSNET, there were 758,324 Veterans who had a service-connected condition and died between the years 2004 and 2014. Using the scrambled social security number to <span class="hlt">link</span> the two files resulted in 605,493 (80%) deceased Veterans. Age at <span class="hlt">death</span>, sex, and underlying cause of <span class="hlt">death</span> were obtained from the NDI for Veterans and military service characteristics and types of disability were acquired from VETSNET. We constructed age categories corresponding to period of service; birth years 1938 and earlier corresponded to Korea and World War II ("oldest"), birth years 1939-1957 to the Vietnam era ("middle"), and birth years 1958 and later to post Vietnam, Gulf War, and the more recent conflicts in Iraq and Afghanistan ("youngest"). Sixty-two percent were in the oldest age category, 34% in the middle group, and 4% in the youngest one. The overall age at <span class="hlt">death</span> was 75 ± 13 yr. Only 1.6% of decedents were women; among women 25% were in the youngest age group, while among men only 4% were in the youngest group. Most decedents were enlisted personnel, and 60% served in the U.S. Army. Nearly 61% had a disability rating of >50% and for the middle age group 54% had a disability rating of 100%. The most common service-connected conditions were tinnitus, hearing loss, and post-traumatic stress disorder (PTSD). In the oldest group, nearly half of <span class="hlt">deaths</span> were due to</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23501831','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23501831"><span><span class="hlt">Linking</span> genomics and ecology to investigate the complex evolution of an invasive Drosophila pest.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ometto, Lino; Cestaro, Alessandro; Ramasamy, Sukanya; Grassi, Alberto; Revadi, Santosh; Siozios, Stefanos; Moretto, Marco; Fontana, Paolo; Varotto, Claudio; Pisani, Davide; Dekker, Teun; Wrobel, Nicola; Viola, Roberto; Pertot, Ilaria; Cavalieri, Duccio; Blaxter, Mark; Anfora, Gianfranco; Rota-Stabelli, Omar</p> <p>2013-01-01</p> <p>Drosophilid fruit flies have provided science with striking cases of behavioral adaptation and genetic innovation. A recent example is the invasive pest Drosophila suzukii, which, unlike most other Drosophila, lays eggs and feeds on undamaged, ripening fruits. This not only poses a serious threat for fruit cultivation but also offers an interesting model to study evolution of behavioral innovation. We developed genome and transcriptome resources for D. suzukii. Coupling analyses of these data with field observations, we propose a hypothesis of the origin of its peculiar ecology. Using nuclear and mitochondrial phylogenetic analyses, we confirm its Asian origin and reveal a surprising <span class="hlt">sister</span> relationship between the eugracilis and the melanogaster subgroups. Although the D. suzukii genome is comparable in size and repeat content to other Drosophila species, it has the lowest nucleotide substitution rate among the species analyzed in this study. This finding is compatible with the overwintering diapause of D. suzukii, which results in a reduced number of generations per year compared with its <span class="hlt">sister</span> species. Genome-scale relaxed clock analyses support a late Miocene origin of D. suzukii, concomitant with paleogeological and climatic conditions that suggest an adaptation to temperate montane forests, a hypothesis confirmed by field trapping. We propose a causal <span class="hlt">link</span> between the ecological adaptations of D. suzukii in its native habitat and its invasive success in Europe and North America.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3641628','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3641628"><span><span class="hlt">Linking</span> Genomics and Ecology to Investigate the Complex Evolution of an Invasive Drosophila Pest</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ometto, Lino; Cestaro, Alessandro; Ramasamy, Sukanya; Grassi, Alberto; Revadi, Santosh; Siozios, Stefanos; Moretto, Marco; Fontana, Paolo; Varotto, Claudio; Pisani, Davide; Dekker, Teun; Wrobel, Nicola; Viola, Roberto; Pertot, Ilaria; Cavalieri, Duccio; Blaxter, Mark; Anfora, Gianfranco; Rota-Stabelli, Omar</p> <p>2013-01-01</p> <p>Drosophilid fruit flies have provided science with striking cases of behavioral adaptation and genetic innovation. A recent example is the invasive pest Drosophila suzukii, which, unlike most other Drosophila, lays eggs and feeds on undamaged, ripening fruits. This not only poses a serious threat for fruit cultivation but also offers an interesting model to study evolution of behavioral innovation. We developed genome and transcriptome resources for D. suzukii. Coupling analyses of these data with field observations, we propose a hypothesis of the origin of its peculiar ecology. Using nuclear and mitochondrial phylogenetic analyses, we confirm its Asian origin and reveal a surprising <span class="hlt">sister</span> relationship between the eugracilis and the melanogaster subgroups. Although the D. suzukii genome is comparable in size and repeat content to other Drosophila species, it has the lowest nucleotide substitution rate among the species analyzed in this study. This finding is compatible with the overwintering diapause of D. suzukii, which results in a reduced number of generations per year compared with its <span class="hlt">sister</span> species. Genome-scale relaxed clock analyses support a late Miocene origin of D. suzukii, concomitant with paleogeological and climatic conditions that suggest an adaptation to temperate montane forests, a hypothesis confirmed by field trapping. We propose a causal <span class="hlt">link</span> between the ecological adaptations of D. suzukii in its native habitat and its invasive success in Europe and North America. PMID:23501831</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4199498','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4199498"><span>The Chromosomal Association of the Smc5/6 Complex Depends on Cohesion and Predicts the Level of <span class="hlt">Sister</span> Chromatid Entanglement</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Jeppsson, Kristian; Carlborg, Kristian K.; Nakato, Ryuichiro; Berta, Davide G.; Lilienthal, Ingrid; Kanno, Takaharu; Lindqvist, Arne; Brink, Maartje C.; Dantuma, Nico P.; Katou, Yuki; Shirahige, Katsuhiko; Sjögren, Camilla</p> <p>2014-01-01</p> <p>The cohesin complex, which is essential for <span class="hlt">sister</span> chromatid cohesion and chromosome segregation, also inhibits resolution of <span class="hlt">sister</span> chromatid intertwinings (SCIs) by the topoisomerase Top2. The cohesin-related Smc5/6 complex (Smc5/6) instead accumulates on chromosomes after Top2 inactivation, known to lead to a buildup of unresolved SCIs. This suggests that cohesin can influence the chromosomal association of Smc5/6 via its role in SCI protection. Using high-resolution ChIP-sequencing, we show that the localization of budding yeast Smc5/6 to duplicated chromosomes indeed depends on <span class="hlt">sister</span> chromatid cohesion in wild-type and top2-4 cells. Smc5/6 is found to be enriched at cohesin binding sites in the centromere-proximal regions in both cell types, but also along chromosome arms when replication has occurred under Top2-inhibiting conditions. Reactivation of Top2 after replication causes Smc5/6 to dissociate from chromosome arms, supporting the assumption that Smc5/6 associates with a Top2 substrate. It is also demonstrated that the amount of Smc5/6 on chromosomes positively correlates with the level of missegregation in top2-4, and that Smc5/6 promotes segregation of short chromosomes in the mutant. Altogether, this shows that the chromosomal localization of Smc5/6 predicts the presence of the chromatid segregation-inhibiting entities which accumulate in top2-4 mutated cells. These are most likely SCIs, and our results thus indicate that, at least when Top2 is inhibited, Smc5/6 facilitates their resolution. PMID:25329383</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5743550','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5743550"><span>Tumour Vascular Shutdown and Cell <span class="hlt">Death</span> Following Ultrasound-Microbubble Enhanced Radiation Therapy</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>El Kaffas, Ahmed; Gangeh, Mehrdad J.; Farhat, Golnaz; Tran, William Tyler; Hashim, Amr; Giles, Anoja; Czarnota, Gregory J.</p> <p>2018-01-01</p> <p>High-dose radiotherapy effects are regulated by acute tumour endothelial cell <span class="hlt">death</span> followed by rapid tumour cell <span class="hlt">death</span> instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. This study aimed to confirm acute and longitudinal relationships between vascular shutdown and tumour cell <span class="hlt">death</span> following radiation and USMB in a wild type murine fibrosarcoma model using in vivo imaging. Methods: Tumour xenografts were treated with single radiation doses of 2 or 8 Gy alone, or in combination with low-/high-concentration USMB. Vascular changes and tumour cell <span class="hlt">death</span> were evaluated at 3, 24 and 72 h following therapy, using high-frequency 3D power Doppler and quantitative ultrasound spectroscopy (QUS) methods, respectively. Staining using in situ end labelling (ISEL) and cluster of differentiation 31 (CD31) of tumour sections were used to assess cell <span class="hlt">death</span> and vascular distributions, respectively, as gold standard histological methods. Results: Results indicated a decrease in the power Doppler signal of up to 50%, and an increase of more than 5 dBr in cell-<span class="hlt">death</span> <span class="hlt">linked</span> QUS parameters at 24 h for tumours treated with combined USMB and radiotherapy. Power Doppler and quantitative ultrasound results were significantly correlated with CD31 and ISEL staining results (p < 0.05), respectively. Moreover, a relationship was found between ultrasound power Doppler and QUS results, as well as between micro-vascular densities (CD31) and the percentage of cell <span class="hlt">death</span> (ISEL) (R2 0.5-0.9). Conclusions: This study demonstrated, for the first time, the <span class="hlt">link</span> between acute vascular shutdown and acute tumour cell <span class="hlt">death</span> using in vivo longitudinal imaging, contributing to the development of theoretical models that incorporate vascular effects in radiation therapy. Overall, this study paves the way for theranostic use of ultrasound in radiation oncology as a diagnostic modality to</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Religious+AND+sacred&pg=7&id=EJ772803','ERIC'); return false;" href="https://eric.ed.gov/?q=Religious+AND+sacred&pg=7&id=EJ772803"><span>Scaling the Heights of Heaven: <span class="hlt">Sister</span> M. Rosalia Walsh and the Use of Story in "The Adaptive Way"</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Nolan, Lucinda A.</p> <p>2007-01-01</p> <p>The work of <span class="hlt">Sister</span> M. Rosalia Walsh and the Mission Helpers of the Sacred Heart gave impetus to the reemergence of the use of story in catechetical materials designed and published in the United States during the first half of the twentieth century. Focused on catechetical needs of Catholic children who did not attend Catholic schools, The Mission…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23602307','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23602307"><span>Suicide and <span class="hlt">death</span> ideation in older adults obtaining aging services.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>O'Riley, Alisa A; Van Orden, Kimberly A; He, Hua; Richardson, Thomas M; Podgorski, Carol; Conwell, Yeates</p> <p>2014-06-01</p> <p>To assess the frequency and correlates of <span class="hlt">death</span> and suicide ideation in older adults accessing aging services. Cross-sectional. Data for this study were collected via in-home interviews. Aging Services Network (ASN) care management clients aged 60 years and older (N = 377) were recruited for this study. The PHQ-9 and the Paykel Suicide Scale were used to assess <span class="hlt">death</span> and suicide ideation. Correlates of <span class="hlt">death</span> and suicide ideation were also examined. Fourteen percent of subjects endorsed current <span class="hlt">death</span> or suicide ideation, 27.9% of subjects endorsed <span class="hlt">death</span> ideation in the past year, and 9.3% of subjects endorsed suicide ideation in the last year. Current <span class="hlt">death</span> and suicide ideation were associated with greater depressive symptoms. As compared with individuals without ideation, individuals with <span class="hlt">death</span> ideation demonstrated higher levels of depressive symptoms, more medical conditions, and lower social support. Individuals with suicide ideation demonstrated higher depressive and anxiety symptoms and less perceived social support. Finally, as compared with individuals with <span class="hlt">death</span> ideation, individuals with suicide ideation demonstrated higher depressive and anxiety symptoms and more alcohol misuse. <span class="hlt">Death</span> and suicide ideation are common among ASN clients. There were both differences and similarities between correlates of <span class="hlt">death</span> and suicide ideation. ASN providers are uniquely situated to address many of the correlates of suicide ideation identified in this study; in order to effectively manage suicide ideation in an ASN setting, however, <span class="hlt">links</span> to primary and mental health care providers are necessary. Copyright © 2014 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3029772','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3029772"><span>Birth and <span class="hlt">death</span> of genes <span class="hlt">linked</span> to chromosomal inversion</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Furuta, Yoshikazu; Kawai, Mikihiko; Yahara, Koji; Takahashi, Noriko; Handa, Naofumi; Tsuru, Takeshi; Oshima, Kenshiro; Yoshida, Masaru; Azuma, Takeshi; Hattori, Masahira; Uchiyama, Ikuo; Kobayashi, Ichizo</p> <p>2011-01-01</p> <p>The birth and <span class="hlt">death</span> of genes is central to adaptive evolution, yet the underlying genome dynamics remain elusive. The availability of closely related complete genome sequences helps to follow changes in gene contents and clarify their relationship to overall genome organization. Helicobacter pylori, bacteria in our stomach, are known for their extreme genome plasticity through mutation and recombination and will make a good target for such an analysis. In comparing their complete genome sequences, we found that gain and loss of genes (loci) for outer membrane proteins, which mediate host interaction, occurred at breakpoints of chromosomal inversions. Sequence comparison there revealed a unique mechanism of DNA duplication: DNA duplication associated with inversion. In this process, a DNA segment at one chromosomal locus is copied and inserted, in an inverted orientation, into a distant locus on the same chromosome, while the entire region between these two loci is also inverted. Recognition of this and three more inversion modes, which occur through reciprocal recombination between long or short sequence similarity or adjacent to a mobile element, allowed reconstruction of synteny evolution through inversion events in this species. These results will guide the interpretation of extensive DNA sequencing results for understanding long- and short-term genome evolution in various organisms and in cancer cells. PMID:21212362</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29389917','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29389917"><span>Surveillance for Violent <span class="hlt">Deaths</span> -
National Violent <span class="hlt">Death</span> Reporting System, 18 States, 2014.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fowler, Katherine A; Jack, Shane P D; Lyons, Bridget H; Betz, Carter J; Petrosky, Emiko</p> <p>2018-02-02</p> <p>In 2014, approximately 59,000 persons died in the United States as a result of violence-related injuries. This report summarizes data from CDC's National Violent <span class="hlt">Death</span> Reporting System (NVDRS) regarding violent <span class="hlt">deaths</span> from 18 U.S. states for 2014. Results are reported by sex, age group, race/ethnicity, marital status, location of injury, method of injury, circumstances of injury, and other selected characteristics. 2014. NVDRS collects data from participating states regarding violent <span class="hlt">deaths</span>. Data are obtained from <span class="hlt">death</span> certificates, coroner/medical examiner reports, law enforcement reports, and secondary sources (e.g., child fatality review team data, supplemental homicide reports, hospital data, and crime laboratory data). This report includes data from 18 states that collected statewide data for 2014 (Alaska, Colorado, Georgia, Kentucky, Maryland, Massachusetts, Michigan, New Jersey, New Mexico, North Carolina, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Virginia, and Wisconsin). NVDRS collates documents for each <span class="hlt">death</span> and <span class="hlt">links</span> <span class="hlt">deaths</span> that are related (e.g., multiple homicides, a homicide followed by a suicide, or multiple suicides) into a single incident. For 2014, a total of 22,098 fatal incidents involving 22,618 <span class="hlt">deaths</span> were captured by NVDRS in the 18 states included in this report. The majority of <span class="hlt">deaths</span> were suicides (65.6%), followed by homicides (22.5%), <span class="hlt">deaths</span> of undetermined intent (10.0%), <span class="hlt">deaths</span> involving legal intervention (1.3%) (i.e., <span class="hlt">deaths</span> caused by law enforcement and other persons with legal authority to use deadly force, excluding legal executions), and unintentional firearm <span class="hlt">deaths</span> (<1%). The term "legal intervention" is a classification incorporated into the International Classification of Diseases, Tenth Revision (ICD-10) and does not denote the lawfulness or legality of the circumstances surrounding a <span class="hlt">death</span> caused by law enforcement. Suicides occurred at higher rates among males, non-Hispanic American Indian/Alaska Natives</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26168197','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26168197"><span>Divorce and <span class="hlt">Death</span>: A Meta-Analysis and Research Agenda for Clinical, Social, and Health Psychology.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sbarra, David A; Law, Rita W; Portley, Robert M</p> <p>2011-09-01</p> <p>Divorce is a relatively common stressful life event that is purported to increase risk for all-cause mortality. One problem in the literature on divorce and health is that it is fragmented and spread across many disciplines; most prospective studies of mortality are based in epidemiology and sociology, whereas most mechanistic studies are based in psychology. This review integrates research on divorce and <span class="hlt">death</span> via meta-analysis and outlines a research agenda for better understanding the potential mechanisms <span class="hlt">linking</span> marital dissolution and risk for all-cause mortality. Random effects meta-analysis with a sample of 32 prospective studies (involving more than 6.5 million people, 160,000 <span class="hlt">deaths</span>, and over 755,000 divorces in 11 different countries) revealed a significant increase in risk for early <span class="hlt">death</span> among separated/divorced adults in comparison to their married counterparts. Men and younger adults evidenced significantly greater risk for early <span class="hlt">death</span> following marital separation/divorce than did women and older adults. Quantification of the overall effect size <span class="hlt">linking</span> marital separation/divorce to risk for early <span class="hlt">death</span> reveals a number of important research questions, and this article discusses what remains to be learned about four plausible mechanisms of action: social selection, resource disruptions, changes in health behaviors, and chronic psychological distress. © Association for Psychological Science 2011.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29785836','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29785836"><span>Facing <span class="hlt">death</span> alone or together? Investigating the interdependence of <span class="hlt">death</span> anxiety, dysfunctional attitudes and quality of life in patient-caregiver dyads confronting lung cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lau, Bobo Hi-Po; Wong, Daniel F K; Fung, Y L; Zhou, Jillian; Chan, Cecilia L W; Chow, Amy Y M</p> <p>2018-05-21</p> <p>Based on the cognitive theory, anxiety arising from the awareness of <span class="hlt">death</span> and dying may activate dysfunctional attitudes, which may then reduce quality of life. This study examined the interdependence and the mediating role of dysfunctional attitudes on the relationship between <span class="hlt">death</span> anxiety and quality of life among patients with lung cancer and their caregivers. From March 2016 to April 2017, 173 pairs of patients and their caregivers enrolled in a randomized controlled trial of psychosocial support. Using the baseline data, actor-partner interdependence modelling was used to analyze the relationships among <span class="hlt">death</span> anxiety, dysfunctional attitudes and quality of life. In patients, <span class="hlt">death</span> anxiety was related to dependency (β=.51) and self-control (β=-.37); achievement (β=-.21) and self-control (β=.34) were related to quality of life. Among caregivers, <span class="hlt">death</span> anxiety was related to all three dysfunctional attitudes of their own (βs=.23 to.32); dependency (β=-.22) was associated with quality of life. Caregiver quality of life were also associated with patient self-control (β=.22) and achievement (β=-.18). Patient self-control mediated the <span class="hlt">links</span> between patient <span class="hlt">death</span> anxiety with both patient and caregiver quality of life. The relationship between <span class="hlt">death</span> anxiety and quality of life was mediated by dependency in caregivers. <span class="hlt">Death</span> anxiety influences dysfunctional attitudes and quality of life of both patients and caregivers. Our results support the relevance of dysfunctional attitudes in understanding the impact of <span class="hlt">death</span> anxiety and underscore the need for parallel psychosocial interventions. This article is protected by copyright. All rights reserved.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_16 --> <div id="page_17" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="321"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3378089','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3378089"><span>Integrin-<span class="hlt">Linked</span> Kinase Deletion in the Developing Lens Leads to Capsule Rupture, Impaired Fiber Migration and Non-Apoptotic Epithelial Cell <span class="hlt">Death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Cammas, Laura; Wolfe, Jordan; Choi, Sue-Yeon; Dedhar, Shoukat; Beggs, Hilary E</p> <p>2012-01-01</p> <p>Purpose. The lens is a powerful model system to study integrin-mediated cell-matrix interaction in an in vivo context, as it is surrounded by a true basement membrane, the lens capsule. To characterize better the function of integrin-<span class="hlt">linked</span> kinase (ILK), we examined the phenotypic consequences of its deletion in the developing mouse lens. Methods. ILK was deleted from the embryonic lens either at the time of placode invagination using the Le-Cre line or after initial lens formation using the Nestin-Cre line. Results. Early deletion of ILK leads to defects in extracellular matrix deposition that result in lens capsule rupture at the lens vesicle stage (E13.5). If ILK was deleted at a later time-point after initial establishment of the lens capsule, rupture was prevented. Instead, ILK deletion resulted in secondary fiber migration defects and, most notably, in cell <span class="hlt">death</span> of the anterior epithelium (E18.5 − P0). Remarkably, dying cells did not stain positively for terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) or activated-caspase 3, suggesting that they were dying from a non-apoptotic mechanism. Moreover, cross to a Baxfl/fl/Bak−/− mouse line that is resistant to most forms of apoptosis failed to promote cell survival in the ILK-deleted lens epithelium. Electron microscopy revealed the presence of numerous membranous vacuoles containing degrading cellular material. Conclusions. Our study reveals a role for ILK in extracellular matrix organization, fiber migration, and cell survival. Furthermore, to our knowledge we show for the first time that ILK disruption results in non-apoptotic cell <span class="hlt">death</span> in vivo. PMID:22491404</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=The+AND+Seven+AND+Sisters&pg=2&id=EJ556456','ERIC'); return false;" href="https://eric.ed.gov/?q=The+AND+Seven+AND+Sisters&pg=2&id=EJ556456"><span>The African American Female Elite: The Early History of African American Women in the Seven <span class="hlt">Sister</span> Colleges, 1880-1960.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Perkins, Linda M.</p> <p>1997-01-01</p> <p>Examination of the experiences of over 500 African American women who attended Seven <span class="hlt">Sisters</span> Colleges shows that some colleges admitted them readily, some only under great pressure. Reflecting the larger society, issues of discrimination in admissions, housing, and financial aid were influenced by and had an effect on the overall struggle for…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.marchofdimes.org/complications/neonatal-death.aspx','NIH-MEDLINEPLUS'); return false;" href="https://www.marchofdimes.org/complications/neonatal-death.aspx"><span>Neonatal <span class="hlt">Death</span></span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... Home > Complications & Loss > Loss & grief > Neonatal <span class="hlt">death</span> Neonatal <span class="hlt">death</span> E-mail to a friend Please fill in ... cope with your baby’s <span class="hlt">death</span>. What is neonatal <span class="hlt">death</span>? Neonatal <span class="hlt">death</span> is when a baby dies in ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26620802','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26620802"><span>Chloroplast phylogenomic analysis of chlorophyte green algae identifies a novel lineage <span class="hlt">sister</span> to the Sphaeropleales (Chlorophyceae).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lemieux, Claude; Vincent, Antony T; Labarre, Aurélie; Otis, Christian; Turmel, Monique</p> <p>2015-12-01</p> <p>The class Chlorophyceae (Chlorophyta) includes morphologically and ecologically diverse green algae. Most of the documented species belong to the clade formed by the Chlamydomonadales (also called Volvocales) and Sphaeropleales. Although studies based on the nuclear 18S rRNA gene or a few combined genes have shed light on the diversity and phylogenetic structure of the Chlamydomonadales, the positions of many of the monophyletic groups identified remain uncertain. Here, we used a chloroplast phylogenomic approach to delineate the relationships among these lineages. To generate the analyzed amino acid and nucleotide data sets, we sequenced the chloroplast DNAs (cpDNAs) of 24 chlorophycean taxa; these included representatives from 16 of the 21 primary clades previously recognized in the Chlamydomonadales, two taxa from a coccoid lineage (Jenufa) that was suspected to be <span class="hlt">sister</span> to the Golenkiniaceae, and two sphaeroplealeans. Using Bayesian and/or maximum likelihood inference methods, we analyzed an amino acid data set that was assembled from 69 cpDNA-encoded proteins of 73 core chlorophyte (including 33 chlorophyceans), as well as two nucleotide data sets that were generated from the 69 genes coding for these proteins and 29 RNA-coding genes. The protein and gene phylogenies were congruent and robustly resolved the branching order of most of the investigated lineages. Within the Chlamydomonadales, 22 taxa formed an assemblage of five major clades/lineages. The earliest-diverging clade displayed Hafniomonas laevis and the Crucicarteria, and was followed by the Radicarteria and then by the Chloromonadinia. The latter lineage was <span class="hlt">sister</span> to two superclades, one consisting of the Oogamochlamydinia and Reinhardtinia and the other of the Caudivolvoxa and Xenovolvoxa. To our surprise, the Jenufa species and the two spine-bearing green algae belonging to the Golenkinia and Treubaria genera were recovered in a highly supported monophyletic group that also included three taxa</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26169512','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26169512"><span>Causes of <span class="hlt">death</span> in people with liver cirrhosis in England compared with the general population: a population-based cohort study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ratib, Sonia; Fleming, Kate M; Crooks, Colin J; Walker, Alex J; West, Joe</p> <p>2015-08-01</p> <p>There is a need for unbiased estimates of cause-specific mortality by etiology in patients with liver cirrhosis. The aim of this study is to use nationwide <span class="hlt">linked</span> electronic routine healthcare data from primary and secondary care alongside the national <span class="hlt">death</span> registry data to report such estimates. We identified from the <span class="hlt">linked</span> Clinical Practice Research Datalink (CPRD) and English Hospital Episode Statistics adults with an incident diagnosis of liver cirrhosis <span class="hlt">linked</span> to the Office for National Statistics between 1998 and 2009. Age-matched controls from the CPRD general population were selected. We calculated the cumulative incidence (adjusting for competing risks) and excess risk of <span class="hlt">death</span> by 5 years from diagnosis for different causes of <span class="hlt">death</span>, stratified by etiology and stage of disease. Five thousand one hundred and eighteen patients with cirrhosis were matched to 152,903 controls. Among compensated patients, the 5-year excess risk of liver-related <span class="hlt">death</span> was higher than that of any other cause of <span class="hlt">death</span> for all patients, except those of unspecified etiology. For example, those of alcohol etiology had 30.8% excess risk of liver-related <span class="hlt">death</span> (95% confidence interval (CI): 27.9%, 33.1%) compared with 9.9% excess risk of non-liver-related <span class="hlt">death</span>. However, patients of unspecified etiology had a higher excess risk of non-liver-related compared with liver-related <span class="hlt">death</span> (10.7% vs. 6.7%). This was due to a high excess risk of non-liver neoplasm <span class="hlt">death</span> (7.7%, 95% CI: 5.9%, 9.5%). All decompensated patients had a higher excess of liver-related mortality than any other cause. In order to reduce associated mortality among people with liver cirrhosis, patients' care pathways need to be tailored depending on the etiology and stage of the disease.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/2009589','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/2009589"><span><span class="hlt">Sister</span> chromatid exchange in children of Seventh-Day Adventists and matched controls.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hermansen, R; Waksvik, H; Fønnebø, V</p> <p>1991-03-01</p> <p>The low risk of cancer in Seventh-Day Adventists (SDAs) has been suggested to be due to genetic selection. To investigate this claim we examined the <span class="hlt">sister</span> chromatid exchange (SCE) frequency in peripheral blood lymphocytes in 16 SDA children in Tromsø, all aged 0.5-8 years and 16 controls matched for sex and age. In 12 of 16 pairs, the SDA children had a lower SCE frequency than the controls. The mean difference was 4.06 (95% confidence interval -17.02-8.89, P = 0.51). There was no sex difference, and no correlation between age and SCE frequency. The genetic starting point with regard to SCE frequency seems to be the same for SDA children and controls.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28490282','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28490282"><span><span class="hlt">Death</span> Cafe.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Miles, Lizzy; Corr, Charles A</p> <p>2017-06-01</p> <p>This article explains the meaning of the phrase <span class="hlt">Death</span> Cafe and describes what typically occurs at a <span class="hlt">Death</span> Cafe gathering. The article traces the history of the <span class="hlt">Death</span> Cafe movement, explores some reasons why people take part in a <span class="hlt">Death</span> Cafe gathering, and gives examples of what individuals think they might derive from their participation. In addition, this article notes similarities between the <span class="hlt">Death</span> Cafe movement and three other developments in the field of <span class="hlt">death</span>, dying, and bereavement. Finally, this article identifies two provisional lessons that can be drawn from <span class="hlt">Death</span> Cafe gatherings and the <span class="hlt">Death</span> Cafe movement itself.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21540319','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21540319"><span>Utility of the National <span class="hlt">Death</span> Index in ascertaining mortality in acquired immunodeficiency syndrome surveillance.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Trepka, Mary Jo; Maddox, Lorene M; Lieb, Spencer; Niyonsenga, Theophile</p> <p>2011-07-01</p> <p>To assess the utility of the National <span class="hlt">Death</span> Index (NDI) in improving the ascertainment of <span class="hlt">deaths</span> among people diagnosed with acquired immunodeficiency syndrome (AIDS), the authors determined the number and characteristics of additional <span class="hlt">deaths</span> identified through NDI linkage not ascertained by using standard electronic linkage with Florida Vital Records and the Social Security Administration's <span class="hlt">Death</span> Master File. Records of people diagnosed with acquired immunodeficiency syndrome between 1993 and 2007 in Florida were <span class="hlt">linked</span> to the NDI. The demographic characteristics and reported human immunodeficiency virus (HIV) transmission modes of people whose <span class="hlt">deaths</span> were identified by using the NDI were compared with those whose <span class="hlt">deaths</span> were ascertained by standard linkage methods. Of the 15,094 submitted records, 719 had confirmed matches, comprising 2.1% of known <span class="hlt">deaths</span> (n = 34,504) within the cohort. Hispanics, males, people 40 years of age or older, and injection drug users were overrepresented among <span class="hlt">deaths</span> ascertained only by the NDI. In-state <span class="hlt">deaths</span> comprised 59.0% of newly identified <span class="hlt">deaths</span>, and human immunodeficiency virus was less likely to be a cause of <span class="hlt">death</span> among newly identified compared with previously identified <span class="hlt">deaths</span>. The newly identified <span class="hlt">deaths</span> were not previously ascertained principally because of slight differences in personal identifying information and could have been identified through improved linkages with Florida Vital Records.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.usgs.gov/sir/2017/5022/i/sir2017-5022i.pdf','USGSPUBS'); return false;" href="https://pubs.usgs.gov/sir/2017/5022/i/sir2017-5022i.pdf"><span>Emplacement of Holocene silicic lava flows and domes at Newberry, South <span class="hlt">Sister</span>, and Medicine Lake volcanoes, California and Oregon</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Fink, Jonathan H.; Anderson, Steven W.</p> <p>2017-07-19</p> <p>This field guide for the International Association of Volcanology and Chemistry of the Earth’s Interior (IAVCEI) Scientific Assembly 2017 focuses on Holocene glassy silicic lava flows and domes on three volcanoes in the Cascade Range in Oregon and California: Newberry, South <span class="hlt">Sister</span>, and Medicine Lake volcanoes. Although obsidian-rich lava flows have been of interest to geologists, archaeologists, pumice miners, and rock hounds for more than a century, many of their emplacement characteristics had not been scientifically observed until two very recent eruptions in Chile. Even with the new observations, several eruptive processes discussed in this field trip guide can only be inferred from their final products. This makes for lively debates at outcrops, just as there have been in the literature for the past 30 years.Of the three volcanoes discussed in this field guide, one (South <span class="hlt">Sister</span>) lies along the main axis defined by major peaks of the Cascade Range, whereas the other two lie in extensional tectonic settings east of the axis. These two tectonic environments influence volcano morphology and the magmatic and volcanic processes that form silicic lava flows and domes. The geomorphic and textural features of glass-rich extrusions provide many clues about their emplacement and the magma bodies that fed them.The scope of this field guide does not include a full geologic history or comprehensive explanation of hazards associated with a particular volcano or volcanic field. The geochemistry, petrology, tectonics, and eruption history of Newberry, South <span class="hlt">Sister</span>, and Medicine Lake volcanic centers have been extensively studied and are discussed on other field excursions. Instead, we seek to explore the structural, textural, and geochemical evolution of well-preserved individual lava flows—the goal is to understand the geologic processes, rather than the development, of a specific volcano.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011JBO....16b6017F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011JBO....16b6017F"><span>Detecting cell <span class="hlt">death</span> with optical coherence tomography and envelope statistics</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Farhat, Golnaz; Yang, Victor X. D.; Czarnota, Gregory J.; Kolios, Michael C.</p> <p>2011-02-01</p> <p>Currently no standard clinical or preclinical noninvasive method exists to monitor cell <span class="hlt">death</span> based on morphological changes at the cellular level. In our past work we have demonstrated that quantitative high frequency ultrasound imaging can detect cell <span class="hlt">death</span> in vitro and in vivo. In this study we apply quantitative methods previously used with high frequency ultrasound to optical coherence tomography (OCT) to detect cell <span class="hlt">death</span>. The ultimate goal of this work is to use these methods for optically-based clinical and preclinical cancer treatment monitoring. Optical coherence tomography data were acquired from acute myeloid leukemia cells undergoing three modes of cell <span class="hlt">death</span>. Significant increases in integrated backscatter were observed for cells undergoing apoptosis and mitotic arrest, while necrotic cells induced a decrease. These changes appear to be <span class="hlt">linked</span> to structural changes observed in histology obtained from the cell samples. Signal envelope statistics were analyzed from fittings of the generalized gamma distribution to histograms of envelope intensities. The parameters from this distribution demonstrated sensitivities to morphological changes in the cell samples. These results indicate that OCT integrated backscatter and first order envelope statistics can be used to detect and potentially differentiate between modes of cell <span class="hlt">death</span> in vitro.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24962877','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24962877"><span>Meaning of <span class="hlt">death</span>: an exploration of perception of elderly in a Bangladeshi village.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Joarder, Taufique; Cooper, Alicia; Zaman, Shahaduz</p> <p>2014-09-01</p> <p>The aim of this qualitative study was to explore the perceptions of meaning of <span class="hlt">death</span> among the elderly in a Bangladeshi community, and to understand how the meaning of <span class="hlt">death</span> affects one's overall well-being. Understandings of <span class="hlt">death</span> were explored through the explanations respondents provided on the journey of the soul during lifetime and the afterlife, concepts of body-soul duality, and perceived "good" and "bad" <span class="hlt">deaths</span>. The relationship to well-being was expressed in terms of longevity, anxiety/acceptance of <span class="hlt">death</span>, and preferred circumstances for <span class="hlt">death</span>. Seven in-depth interviews and one informal discussion session provided the bulk of the data, while Participatory Rapid Appraisal (PRA) tools, including daily routines and body mapping, supplemented our findings. Elderly members of the community had very specific ideas about the meaning of <span class="hlt">death</span>, and provided clear explanations regarding the journey of the soul, drawing on ideas of body-soul duality to substantiate claims. Due to long coexistence fusion of Hindu and Muslim ideas around <span class="hlt">death</span> was found. Anxiety/fear of <span class="hlt">death</span> was associated with some secular issues, on the contrary the perception of longevity was found <span class="hlt">linked</span> with spirituality. Insights revealed from this study of subtle differences in the perceptions regarding issues around <span class="hlt">death</span> may aid the policy makers develop effective end-of-life interventions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24430165','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24430165"><span>Surveillance for violent <span class="hlt">deaths</span> - National Violent <span class="hlt">Death</span> Reporting System, 16 states, 2010.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Parks, Sharyn E; Johnson, Linda L; McDaniel, Dawn D; Gladden, Matthew</p> <p>2014-01-17</p> <p> apartment and involved the use of firearms. Suicides were preceded primarily by a mental health or intimate partner problem, a crisis during the previous 2 weeks, or a physical health problem. Homicides occurred at higher rates among males and persons aged 20-24 years; rates were highest among non-Hispanic black males. The majority of homicides involved the use of a firearm and occurred in a house or apartment or on a street/highway. Homicides were precipitated primarily by arguments and interpersonal conflicts or in conjunction with another crime. This report provides a detailed summary of data from NVDRS for 2010. The results indicate that violent <span class="hlt">deaths</span> resulting from self-inflicted or interpersonal violence disproportionately affected persons aged <55 years, males, and certain minority populations. For homicides and suicides, relationship problems, interpersonal conflicts, mental health problems, and recent crises were among the primary precipitating factors. Because additional information might be reported subsequently as participating states update their findings, the data provided in this report are preliminary. For the occurrence of violent <span class="hlt">deaths</span> in the United States to be better understood and ultimately prevented, accurate, timely, and comprehensive surveillance data are necessary. NVDRS data can be used to monitor the occurrence of violence-related fatal injuries and assist public health authorities in the development, implementation, and evaluation of programs and policies to reduce and prevent violent <span class="hlt">deaths</span> at the national, state, and local levels. NVDRS data have been used to enhance prevention programs. Examples include use of <span class="hlt">linked</span> NVDRS data and adult protective service data to better target elder maltreatment prevention programs and improve staff training to identify violent <span class="hlt">death</span> risks for older adults in North Carolina, use of Oklahoma VDRS homicide data to help evaluate the effectiveness of a new police and advocate intervention at domestic violence</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28865791','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28865791"><span>Cell <span class="hlt">death</span> pathways of particulate matter toxicity.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Peixoto, Milena Simões; de Oliveira Galvão, Marcos Felipe; Batistuzzo de Medeiros, Silvia Regina</p> <p>2017-12-01</p> <p>Humans are exposed to various complex mixtures of particulate matter (PM) from different sources. Long-term exposure to high levels of these particulates has been <span class="hlt">linked</span> to a diverse range of respiratory and cardiovascular diseases that have resulted in hospital admission. The evaluation of the effects of PM exposure on the mechanisms related to cell <span class="hlt">death</span> has been a challenge for many researchers. Therefore, in this review, we have discussed the effects of airborne PM exposure on mechanisms related to cell <span class="hlt">death</span>. For this purpose, we have compiled literature data on PM sources, the effects of exposure, and the assays and models used for evaluation, in order to establish comparisons between various studies. The analysis of this collected data suggested divergent responses to PM exposure that resulted in different cell <span class="hlt">death</span> types (apoptosis, autophagy, and necrosis). In addition, PM induced oxidative stress within cells, which appeared to be an important factor in the determination of cell fate. When the levels of reactive oxygen species were overpowering, the cellular fate was directed toward cell <span class="hlt">death</span>. This may be the underlying mechanism of the development or exacerbation of respiratory diseases, such as emphysema and chronic obstructive pulmonary diseases. In addition, PM was shown to cause DNA damage and the resulting mutations increased the risk of cancer. Furthermore, several conditions should be considered in the assessment of cell <span class="hlt">death</span> in PM-exposed models, including the cell culture line, PM composition, and the interaction of the different cells types in in vivo models. Copyright © 2017 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2365731','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2365731"><span>Sudden cardiac <span class="hlt">death</span> secondary to antidepressant and antipsychotic drugs</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sicouri, Serge; Antzelevitch, Charles</p> <p>2008-01-01</p> <p>A number of antipsychotic and antidepressant drugs are known to increase the risk of ventricular arrhythmias and sudden cardiac <span class="hlt">death</span>. Based largely on a concern over QT prolongation and the development of life-threatening arrhythmias, a number of antipsychotic drugs have been temporarily or permanently withdrawn from the market or their use restricted. Some antidepressants and antipsychotics have been <span class="hlt">linked</span> to QT prolongation and the development of Torsade de pointes arrhythmias, whereas others have been associated with a Brugada syndrome phenotype and the development of polymorphic ventricular arrhythmias. This review examines the mechanisms and predisposing factors underlying the development of cardiac arrhythmias, and sudden cardiac <span class="hlt">death</span>, associated with antidepressant and antipsychotic drugs in clinical use. PMID:18324881</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3812213','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3812213"><span>Reducing HIV Risk among Transgender Women in Thailand: A Quasi-Experimental Evaluation of the <span class="hlt">Sisters</span> Program</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pawa, Duangta; Firestone, Rebecca; Ratchasi, Sindh; Dowling, Olivia; Jittakoat, Yaowalak; Duke, Alex; Mundy, Gary</p> <p>2013-01-01</p> <p>Transgender women are particularly at risk of HIV infection, but little evidence exists on effective HIV prevention strategies with this population. We evaluated whether <span class="hlt">Sisters</span>, a peer-led program for transgender women, could reduce HIV risks in Pattaya, Thailand. The study used time-location sampling to recruit 308 transgender women in Pattaya into a behavioral survey in 2011. Coarsened exact matching was used to create statistically equivalent groups of program participants and non-participants, based on factors influencing likelihood of program participation. Using multivariable logistic regression, we estimated effects of any program participation and participation by delivery channel on: condom use at last sex; consistent condom and condom/water-based lubricant use in the past 3 months with commercial, casual, and regular partners; and receipt of HIV testing in the past 6 months. Program coverage reached 75% of the population. In a matched sub-sample (n = 238), participation in outreach was associated with consistent condom/water-based lubricant use with commercial partners (AOR 3.22, 95% CI 1.64–6.31). Attendance at the <span class="hlt">Sisters</span> drop-in center was associated with receiving an HIV test (AOR 2.58, 95% CI 1.47–4.52). Dedicated transgender-friendly programs are effective at reducing HIV risks and require expansion to better serve this key population and improve HIV prevention strategies. PMID:24204750</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26162201','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26162201"><span>Recognition and the Fleeting Glimpse of Intimacy: Tracing the Chaplain's Response to Ungrieved <span class="hlt">Death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Coble, Richard</p> <p>2015-03-01</p> <p>The article traces the response of the hospital chaplain witnessing ungrieved <span class="hlt">death</span>. <span class="hlt">Linking</span> grief with cultural recognition, the article analyzes the absence of grief on the occasion of <span class="hlt">death</span> within outcast social spheres. It then outlines the ways chaplains both participate in the cultural norms that render lives ungrievable and, conversely, in the solidarity of God, who cares for every life and <span class="hlt">death</span>. The article closes by situating the chaplain as a liminal figure and proposing liminality itself as an opportunity for solidarity. © The Author(s) 2015 Reprints and permissions:sagepub.co.uk/journalsPermissions.nav.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11686509','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11686509"><span>Is there a <span class="hlt">link</span> between infant botulism and sudden infant <span class="hlt">death</span>? Bacteriological results obtained in central Germany.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Böhnel, H; Behrens, S; Loch, P; Lube, K; Gessler, F</p> <p>2001-10-01</p> <p>Despite the fact that botulism was described in Germany for the first time by Kerner in 1820, the disease is almost forgotten in this country. Only about 10-20 cases of classical botulism (intoxication) are recorded every year, including 1-2 cases of clinical infant botulism. As we assumed a high incidence of botulism to be connected with cases of sudden infant <span class="hlt">death</span> (SID), we undertook the research work presented here. From every case of unexpected infant <span class="hlt">death</span> up to 12 months of age, standardised specimens (blood, liver and intestine) were taken at autopsy. They were tested for the presence of botulinum neurotoxin (BoNT) and/or bacterial forms of Clostridium botulinum with subsequent BoNT neutralisation tests by the international standard mouse bioassay. Age, sex, pathological findings and season were recorded. Over a 5-year period, 75 samples including 57 SID cases were tested. Free toxin was found in nine and bacterial forms were detected in six samples. Toxin neutralisation revealed the definite presence of BoNT/BoNT producing bacteria (mainly type E), whereas another 11 toxin tests were inconclusive. According to international literature, these 15 cases are to be interpreted as infant botulism. the results show a remarkable incidence of infant botulism without any known previous medical history, partly hidden as sudden infant <span class="hlt">death</span>. We propose to systematically search for botulism in connection with sudden infant <span class="hlt">death</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5829936','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5829936"><span>Surveillance for Violent <span class="hlt">Deaths</span> —
National Violent <span class="hlt">Death</span> Reporting System, 18 States, 2014</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Jack, Shane P.D.; Lyons, Bridget H.; Betz, Carter J.; Petrosky, Emiko</p> <p>2018-01-01</p> <p>Problem/Condition In 2014, approximately 59,000 persons died in the United States as a result of violence-related injuries. This report summarizes data from CDC’s National Violent <span class="hlt">Death</span> Reporting System (NVDRS) regarding violent <span class="hlt">deaths</span> from 18 U.S. states for 2014. Results are reported by sex, age group, race/ethnicity, marital status, location of injury, method of injury, circumstances of injury, and other selected characteristics. Reporting Period Covered 2014. Description of System NVDRS collects data from participating states regarding violent <span class="hlt">deaths</span>. Data are obtained from <span class="hlt">death</span> certificates, coroner/medical examiner reports, law enforcement reports, and secondary sources (e.g., child fatality review team data, supplemental homicide reports, hospital data, and crime laboratory data). This report includes data from 18 states that collected statewide data for 2014 (Alaska, Colorado, Georgia, Kentucky, Maryland, Massachusetts, Michigan, New Jersey, New Mexico, North Carolina, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Virginia, and Wisconsin). NVDRS collates documents for each <span class="hlt">death</span> and <span class="hlt">links</span> <span class="hlt">deaths</span> that are related (e.g., multiple homicides, a homicide followed by a suicide, or multiple suicides) into a single incident. Results For 2014, a total of 22,098 fatal incidents involving 22,618 <span class="hlt">deaths</span> were captured by NVDRS in the 18 states included in this report. The majority of <span class="hlt">deaths</span> were suicides (65.6%), followed by homicides (22.5%), <span class="hlt">deaths</span> of undetermined intent (10.0%), <span class="hlt">deaths</span> involving legal intervention (1.3%) (i.e., <span class="hlt">deaths</span> caused by law enforcement and other persons with legal authority to use deadly force, excluding legal executions), and unintentional firearm <span class="hlt">deaths</span> (<1%). The term “legal intervention” is a classification incorporated into the International Classification of Diseases, Tenth Revision (ICD-10) and does not denote the lawfulness or legality of the circumstances surrounding a <span class="hlt">death</span> caused by law enforcement. Suicides</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20624976','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20624976"><span>Origin of a function by tandem gene duplication limits the evolutionary capability of its <span class="hlt">sister</span> copy.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hasselmann, Martin; Lechner, Sarah; Schulte, Christina; Beye, Martin</p> <p>2010-07-27</p> <p>The most remarkable outcome of a gene duplication event is the evolution of a novel function. Little information exists on how the rise of a novel function affects the evolution of its paralogous <span class="hlt">sister</span> gene copy, however. We studied the evolution of the feminizer (fem) gene from which the gene complementary sex determiner (csd) recently derived by tandem duplication within the honey bee (Apis) lineage. Previous studies showed that fem retained its sex determination function, whereas the rise of csd established a new primary signal of sex determination. We observed a specific reduction of nonsynonymous to synonymous substitution ratios in Apis to non-Apis fem. We found a contrasting pattern at two other genetically <span class="hlt">linked</span> genes, suggesting that hitchhiking effects to csd, the locus under balancing selection, is not the cause of this evolutionary pattern. We also excluded higher synonymous substitution rates by relative rate testing. These results imply that stronger purifying selection is operating at the fem gene in the presence of csd. We propose that csd's new function interferes with the function of Fem protein, resulting in molecular constraints and limited evolvability of fem in the Apis lineage. Elevated silent nucleotide polymorphism in fem relative to the genome-wide average suggests that genetic linkage to the csd gene maintained more nucleotide variation in today's population. Our findings provide evidence that csd functionally and genetically interferes with fem, suggesting that a newly evolved gene and its functions can limit the evolutionary capability of other genes in the genome.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26588894','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26588894"><span>Evolutionary comparison of prenylation pathway in kinetoplastid Leishmania and its <span class="hlt">sister</span> Leptomonas.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chauhan, Indira Singh; Kaur, Jaspreet; Krishna, Shagun; Ghosh, Arpita; Singh, Prashant; Siddiqi, Mohammad Imran; Singh, Neeloo</p> <p>2015-11-21</p> <p>Leptomonas is monogenetic kinetoplastid parasite of insects and is primitive in comparison to Leishmania. Comparative studies of these two kinetoplastid may share light on the evolutionary transition to dixenous parasitism in Leishmania. In order to adapt and survive within two hosts, Leishmania species must have acquired virulence factors in addition to mechanisms that mediate susceptibility/resistance to infection in the pathology associated with disease. Rab proteins are key mediators of vesicle transport and contribute greatly to the evolution of complexity of membrane transport system. In this study we used our whole genome sequence data of these two divergent kinetoplastids to analyze the orthologues/paralogues of Rab proteins. During change of lifestyle from monogenetic (Leptomonas) to digenetic (Leishmania), we found that the prenyl machinery remained unchanged. Geranylgeranyl transferase-I (GGTase-I) was absent in both Leishmania and its <span class="hlt">sister</span> Leptomonas. Farnesyltransferase (FTase) and geranylgeranyl transferase-II (GGTase-II) were identified for protein prenylation. We predict that activity of the missing alpha-subunit (α-subunit) of GGTase-II in Leptomonas was probably contributed by the α-subunit of FTase, while beta-subunit (β-subunit) of GGTase-II was conserved and indicated functional conservation in the evolution of these two kinetoplastids. Therefore the β-subunit emerges as an excellent target for compounds inhibiting parasite activity in clinical cases of co-infections. We also confirmed that during the evolution to digenetic life style in Leishmania, the parasite acquired capabilities to evade drug action and maintain parasite virulence in the host with the incorporation of short-chain dehydrogenase/reductase (SDR/MDR) superfamily in Rab genes. Our study based on whole genome sequences is the first to build comparative evolutionary analysis and identification of prenylation proteins in Leishmania and its <span class="hlt">sister</span> Leptomonas. The information</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_17 --> <div id="page_18" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="341"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26941276','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26941276"><span>Hypothesised mechanisms of swimming-related <span class="hlt">death</span>: a systematic review.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Asplund, Chad A; Creswell, Lawrence L</p> <p>2016-11-01</p> <p>Recent reports from triathlon and competitive open-water swimming indicate that these events have higher rates of <span class="hlt">death</span> compared with other forms of endurance sport. The potential causal mechanism for swimming-related <span class="hlt">death</span> is unclear. To examine available studies on the hypothesised mechanisms of swimming-related <span class="hlt">death</span> to determine the most likely aetiologies. MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews (1950 to present) were searched, yielding 1950 potential results, which after title and citation reviews were reduced to 83 possible reports. Studies included discussed mechanisms of <span class="hlt">death</span> during swimming in humans, and were Level 4 evidence or higher. A total of 17 studies (366 total swimmers) were included for further analysis: 5 investigating hyperthermia/hypothermia, 7 examining cardiac mechanisms and responses, and 5 determining the presence of pulmonary edema. The studies provide inconsistent and limited-quality or disease-oriented evidence that make definitive conclusions difficult. The available evidence is limited but may suggest that cardiac arrhythmias are the most likely aetiology of swimming-related <span class="hlt">death</span>. While symptoms of pulmonary edema may occur during swimming, current evidence does not support swimming-induced pulmonary edema as a frequent cause of swimming-related <span class="hlt">death</span>, nor is there evidence to <span class="hlt">link</span> hypothermia or hyperthermia as a causal mechanism. Further higher level studies are needed. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21967038','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21967038"><span>Diversification and the rate of molecular evolution: no evidence of a <span class="hlt">link</span> in mammals.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Goldie, Xavier; Lanfear, Robert; Bromham, Lindell</p> <p>2011-10-04</p> <p>Recent research has indicated a positive association between rates of molecular evolution and diversification in a number of taxa. However debate continues concerning the universality and cause of this relationship. Here, we present the first systematic investigation of this relationship within the mammals. We use phylogenetically independent <span class="hlt">sister</span>-pair comparisons to test for a relationship between substitution rates and clade size at a number of taxonomic levels. Total, non-synonymous and synonymous substitution rates were estimated from mitochondrial and nuclear DNA sequences. We found no evidence for an association between clade size and substitution rates in mammals, for either the nuclear or the mitochondrial sequences. We found significant associations between body size and substitution rates, as previously reported. Our results present a contrast to previous research, which has reported significant positive associations between substitution rates and diversification for birds, angiosperms and reptiles. There are three possible reasons for the differences between the observed results in mammals versus other clades. First, there may be no <span class="hlt">link</span> between substitution rates and diversification in mammals. Second, this <span class="hlt">link</span> may exist, but may be much weaker in mammals than in other clades. Third, the <span class="hlt">link</span> between substitution rates and diversification may exist in mammals, but may be confounded by other variables.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21263065','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21263065"><span>Being me and being us in a family living close to <span class="hlt">death</span> at home.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Carlander, Ida; Ternestedt, Britt-Marie; Sahlberg-Blom, Eva; Hellström, Ingrid; Sandberg, Jonas</p> <p>2011-05-01</p> <p>We used interpretive description to describe how everyday life close to <span class="hlt">death</span> was experienced and dealt with in families with one member who had a life-threatening illness. We performed 28 individual, couple, and group interviews with five families. We found two patterns, namely, "being me in a family living close to <span class="hlt">death</span>" and "being us in a family living close to <span class="hlt">death</span>." "Being me" meant that every individual in the family had to deal with the impending <span class="hlt">death</span>, regardless of whether or not he or she was the person with the life-threatening illness. This was <span class="hlt">linked</span> to ways of promoting the individual's self-image, or "me-ness." This pattern was present at the same time as the pattern of "being us," or in other words, being a family, and dealing with impending <span class="hlt">death</span> and a new "we-ness" as a group. "Striving for the optimal way of living close to <span class="hlt">death</span>" was the core theme.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/1998603','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/1998603"><span>Frequency of <span class="hlt">sister</span> chromatid exchange and chromosomal aberrations in asbestos cement workers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fatma, N; Jain, A K; Rahman, Q</p> <p>1991-02-01</p> <p>Exposure to asbestos minerals has been associated with a wide variety of adverse health effects including lung cancer, pleural mesothelioma, and cancer of other organs. It was shown previously that asbestos samples collected from a local asbestos factory enhanced <span class="hlt">sister</span> chromatid exchanges (SCEs) and chromosomal aberrations in vitro using human lymphocytes. In the present study, 22 workers from the same factory and 12 controls were further investigated. Controls were matched for age, sex, and socioeconomic state. The peripheral blood lymphocytes were cultured and harvested at 48 hours for studies of chromosomal aberrations and at 72 hours for SCE frequency determinations. Asbestos workers had a raised mean SCE rate and increased numbers of chromosomal aberrations compared with a control population. Most of the chromosomal aberrations were chromatid gap and break types.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28648112','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28648112"><span>Narrative research on mental health recovery: two <span class="hlt">sister</span> paradigms.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Spector-Mersel, Gabriela; Knaifel, Evgeny</p> <p>2017-06-24</p> <p>Despite the breadth of narrative studies on individuals with severe mental illness, the suitability of narrative inquiry to exploring mental health recovery (MHR) has not been examined. (1) Examining the appropriateness of narrative inquiry to studying MHR; (2) assessing the extent to which narrative studies on MHR conform to the unique features of narrative research, as a distinctive form of qualitative inquiry. Review of empirical, theoretical and methodological literature on recovery and narrative inquiry. Considering the perspectives of recovery and narrative as paradigms, the similarity between their ontology and epistemology is shown, evident in 10 common emphases: meaning, identity, change and development, agency, holism, culture, uniqueness, context, language and giving voice. The resemblance between these "<span class="hlt">sister</span>" paradigms makes narrative methodology especially fruitful for accessing the experiences of individuals in recovery. Reviewing narrative studies on MHR suggests that, currently, narrative research's uniqueness, centered on the holistic principle, is blurred on the philosophical, methodological and textual levels. Well-established narrative research has major implications for practice and policy in recovery-oriented mental health care. The narrative inquiry paradigm offers a possible path to enhancing the distinctive virtues of this research, realizing its potential in understanding and promoting MHR.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3159427','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3159427"><span>Utility of the National <span class="hlt">Death</span> Index in Ascertaining Mortality in Acquired Immunodeficiency Syndrome Surveillance</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Trepka, Mary Jo; Maddox, Lorene M.; Lieb, Spencer; Niyonsenga, Theophile</p> <p>2011-01-01</p> <p>To assess the utility of the National <span class="hlt">Death</span> Index (NDI) in improving the ascertainment of <span class="hlt">deaths</span> among people diagnosed with acquired immunodeficiency syndrome (AIDS), the authors determined the number and characteristics of additional <span class="hlt">deaths</span> identified through NDI linkage not ascertained by using standard electronic linkage with Florida Vital Records and the Social Security Administration’s <span class="hlt">Death</span> Master File. Records of people diagnosed with acquired immunodeficiency syndrome between 1993 and 2007 in Florida were <span class="hlt">linked</span> to the NDI. The demographic characteristics and reported human immunodeficiency virus (HIV) transmission modes of people whose <span class="hlt">deaths</span> were identified by using the NDI were compared with those whose <span class="hlt">deaths</span> were ascertained by standard linkage methods. Of the 15,094 submitted records, 719 had confirmed matches, comprising 2.1% of known <span class="hlt">deaths</span> (n = 34,504) within the cohort. Hispanics, males, people 40 years of age or older, and injection drug users were overrepresented among <span class="hlt">deaths</span> ascertained only by the NDI. In-state <span class="hlt">deaths</span> comprised 59.0% of newly identified <span class="hlt">deaths</span>, and human immunodeficiency virus was less likely to be a cause of <span class="hlt">death</span> among newly identified compared with previously identified <span class="hlt">deaths</span>. The newly identified <span class="hlt">deaths</span> were not previously ascertained principally because of slight differences in personal identifying information and could have been identified through improved linkages with Florida Vital Records. PMID:21540319</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011IJMES..42..765L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011IJMES..42..765L"><span>Beyond Newton's law of cooling - estimation of time since <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Leinbach, Carl</p> <p>2011-09-01</p> <p>The estimate of the time since <span class="hlt">death</span> and, thus, the time of <span class="hlt">death</span> is strictly that, an estimate. However, the time of <span class="hlt">death</span> can be an important piece of information in some coroner's cases, especially those that involve criminal or insurance investigations. It has been known almost from the beginning of time that bodies cool after the internal mechanisms such as circulation of the blood stop. A first attempt to <span class="hlt">link</span> this phenomenon to the determination of the time of <span class="hlt">death</span> used a crude linear relationship. Towards the end of the nineteenth century, Newton's law of cooling using body temperature data obtained by the coroner was used to make a more accurate estimate. While based on scientific principles and resulting in a better estimate, Newton's law does not really describe the cooling of a non-homogeneous human body. This article will discuss a more accurate model of the cooling process based on the theoretical work of Marshall and Hoare and the laboratory-based statistical work of Claus Henssge. Using DERIVE®6.10 and the statistical work of Henssge, the double exponential cooling formula developed by Marshall and Hoare will be explored. The end result is a tool that can be used in the field by coroner's scene investigators to determine a 95% confidence interval for the time since <span class="hlt">death</span> and, thus, the time of <span class="hlt">death</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017APS..DFD.F7002P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017APS..DFD.F7002P"><span>The life and <span class="hlt">death</span> of film bubbles</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Poulain, S.; Villermaux, E.; Bourouiba, L.</p> <p>2017-11-01</p> <p>Following its burst, the fragmentation of a large bubble (film bubble) at the air-water interface can release hundreds of micrometer-sized film-drops in the air we breathe. This mechanism of droplet formation is one of the most prominent sources of sea spray. Indoor or outdoor, pathogens from contaminated water are transported by these droplets and have also been <span class="hlt">linked</span> to respiratory infection. The lifetime and thickness of bubbles govern the number and size of the droplets they produce. Despite these important implications, little is known about the factors influencing the life and <span class="hlt">death</span> of surface film bubbles. In particular, the fundamental physical mechanisms <span class="hlt">linking</span> bubble aging, thinning, and lifetime remain poorly understood. To address this gap, we present the results of an extensive investigation of the aging of film-drop-producing bubbles in various ambient air, water composition, and temperature conditions. We present and validate a generalized physical picture and model of bubble cap thickness evolution. The model and physical picture are <span class="hlt">linked</span> to the lifetime of bubbles via a series of cap rupture mechanisms of increasing efficiency.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26914589','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26914589"><span>The <span class="hlt">death</span> spiral: predicting <span class="hlt">death</span> in Drosophila cohorts.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mueller, Laurence D; Shahrestani, Parvin; Rauser, Casandra L; Rose, Michael R</p> <p>2016-11-01</p> <p>Drosophila research has identified a new feature of aging that has been called the <span class="hlt">death</span> spiral. The <span class="hlt">death</span> spiral is a period prior to <span class="hlt">death</span> during which there is a decline in life-history characters, such as fecundity, as well as physiological characters. First, we review the data from the Drosophila and medfly literature that suggest the existence of <span class="hlt">death</span> spirals. Second, we re-analyze five cases with such data from four laboratories using a generalized statistical framework, a re-analysis that strengthens the case for the salience of the <span class="hlt">death</span> spiral phenomenon. Third, we raise the issue whether <span class="hlt">death</span> spirals need to be taken into account in the analysis of functional characters over age, in aging research with model species as well as human data.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED470089.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED470089.pdf"><span><span class="hlt">Sister</span> Mary Theresa Brentano, OSB's Innovative Use of Magnetic Audio Tapes: An Overlooked Story in the History of Educational Technology.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Herndon, Linda</p> <p></p> <p>This paper tells the story of <span class="hlt">Sister</span> Mary Theresa Brentano, O.S.B's (1902-1987) innovative use of magnetic audiotapes to provide instruction for students in grades K-12. From 1952 to approximately 1968, Brentano implemented, refined, and tested her tape teaching methods with special emphasis on individualizing instruction in the elementary school.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21404733','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21404733"><span>Deliberating <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Landes, Scott D</p> <p>2010-01-01</p> <p>Utilizing a particular case study of a woman attempting to come to terms with her <span class="hlt">death</span>, this article explores the difficult metaphors of <span class="hlt">death</span> present within the Christian tradition. Tracing a Christian understanding of <span class="hlt">death</span> back to the work of Augustine, the case study is utilized to highlight the difficulties presented by past and present theology embracing ideas of punishment within <span class="hlt">death</span>. Following the trajectory of the case study, alternative understandings of <span class="hlt">death</span> present in recent Christian theology and within Native American spirituality are presented in an attempt to find room for a fuller meaning of <span class="hlt">death</span> post-reconciliation, but premortem.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24139442','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24139442"><span>A prospective study of sudden unexpected infant <span class="hlt">death</span> after reported maltreatment.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Putnam-Hornstein, Emily; Schneiderman, Janet U; Cleves, Mario A; Magruder, Joseph; Krous, Henry F</p> <p>2014-01-01</p> <p>To examine whether infants reported for maltreatment face a heightened risk of sudden infant <span class="hlt">death</span> syndrome (SIDS) and other leading causes of sudden unexpected infant <span class="hlt">death</span> (SUID). <span class="hlt">Linked</span> birth and infant <span class="hlt">death</span> records for all children born in California between 1999 and 2006 were matched to administrative child protection data. Infants were prospectively followed from birth through <span class="hlt">death</span> or 1 year of age. A report of maltreatment was modeled as a time-varying covariate; risk factors at birth were included as baseline covariates. Multivariable competing risk survival models were used to estimate the adjusted relative hazard of postneonatal SIDS and other SUID. A previous maltreatment report emerged as a significant predictor of SIDS and other SUID. After adjusting for baseline risk factors, the rate of SIDS was more than 3 times as great among infants reported for possible maltreatment (hazard ratio: 3.22; 95% CI: 2.66, 3.89). Infants reported to child protective services have a heightened risk of SIDS and other SUID. Targeted services and improved communication between child protective services and the pediatric health care community may enhance infant well-being and reduce risk of <span class="hlt">death</span>. Copyright © 2014 Mosby, Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=target&pg=7&id=EJ1127731','ERIC'); return false;" href="https://eric.ed.gov/?q=target&pg=7&id=EJ1127731"><span>Adolescent Siblings of Individuals with and without Intellectual and Developmental Disabilities: Self-Reported Empathy and Feelings about Their Brothers and <span class="hlt">Sisters</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Shivers, Carolyn M.; Dykens, Elisabeth M.</p> <p>2017-01-01</p> <p>Siblings of brothers or <span class="hlt">sisters</span> with intellectual and developmental disabilities (IDD) are important but understudied family members. As many previous studies have relied on parent report of sibling outcomes, the use of sibling self-report is an important addition to the research. This study assessed the feelings of adolescent siblings toward…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3164808','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3164808"><span>Early Parental <span class="hlt">Death</span> and Remarriage of Widowed Parents as Risk Factors for Alzheimer’s Disease. The Cache County Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Norton, Maria C.; Smith, Ken R.; Østbye, Truls; Tschanz, JoAnn T.; Schwartz, Sarah; Corcoran, Chris; Breitner, John C. S.; Steffens, David C.; Skoog, Ingmar; Rabins, Peter V.; Welsh-Bohmer, Kathleen A.</p> <p>2011-01-01</p> <p>Objectives Early parental <span class="hlt">death</span> is associated with lifelong tendencies toward depression and chronic stress. We tested the hypothesis that, early parental <span class="hlt">death</span> is associated with higher risk for Alzheimer’s disease (AD) in offspring. Design A population-based epidemiological study of dementia with detailed clinical evaluations, <span class="hlt">linked</span> to one of the world’s richest sources of objective genealogical and vital statistics data. Setting Home visits with residents of a rural county in northern Utah. Participants 4,108 subjects, aged 65-105. Measurements Multi-stage dementia ascertainment protocol implemented in four triennial waves, yielding expert consensus diagnoses of 570 participants with AD and 3,538 without dementia. Parental <span class="hlt">death</span> dates, socioeconomic status and parental remarriage after widowhood were obtained from the Utah Population Database, a large genealogical database <span class="hlt">linked</span> to statewide birth and <span class="hlt">death</span> records. Results Mother’s <span class="hlt">death</span> during subject’s adolescence was significantly associated with higher rate of AD in regression models that included age, gender, education, APOE genotype, and socioeconomic status. Father’s <span class="hlt">death</span> before subject age 5 showed a weaker association. In stratified analyses, associations were significant only when the widowed parent did not remarry. Parental <span class="hlt">death</span> associations were not moderated by gender or APOE genotype. Findings were specific to AD and not found for non-AD dementia. Conclusions Parental <span class="hlt">death</span> during childhood is associated with higher prevalence of AD, with different critical periods for father’s vs. mother’s <span class="hlt">death</span>, with strength of these associations attenuated by remarriage of the widowed parent. PMID:21873837</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4565614','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4565614"><span>Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Narayanan, Kannan Badri; Ali, Manaf; Barclay, Barry J.; Cheng, Qiang (Shawn); D’Abronzo, Leandro; Dornetshuber-Fleiss, Rita; Ghosh, Paramita M.; Gonzalez Guzman, Michael J.; Lee, Tae-Jin; Leung, Po Sing; Li, Lin; Luanpitpong, Suidjit; Ratovitski, Edward; Rojanasakul, Yon; Romano, Maria Fiammetta; Romano, Simona; Sinha, Ranjeet K.; Yedjou, Clement; Al-Mulla, Fahd; Al-Temaimi, Rabeah; Amedei, Amedeo; Brown, Dustin G.; Ryan, Elizabeth P.; Colacci, Anna Maria; Hamid, Roslida A.; Mondello, Chiara; Raju, Jayadev; Salem, Hosni K.; Woodrick, Jordan; Scovassi, A.Ivana; Singh, Neetu; Vaccari, Monica; Roy, Rabindra; Forte, Stefano; Memeo, Lorenzo; Kim, Seo Yun; Bisson, William H.; Lowe, Leroy; Park, Hyun Ho</p> <p>2015-01-01</p> <p>Cell <span class="hlt">death</span> is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular <span class="hlt">death</span> is tightly <span class="hlt">linked</span> to cancer progression. Specifically, the up-regulation of pro-survival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of pro-apoptotic factors, including tumor suppressive factors, confers resistance to cell <span class="hlt">death</span> in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell <span class="hlt">death</span>, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis. PMID:26106145</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26771079','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26771079"><span>Sexual dimorphism in <span class="hlt">sister</span> species of Leucoraja skate and its relationship to reproductive strategy and life history.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Martinez, Christopher M; Rohlf, F James; Frisk, Michael G</p> <p>2016-01-01</p> <p>Instances of sexual dimorphism occur in a great variety of forms and manifestations. Most skates (Batoidea: Rajoidei) display some level of body shape dimorphism in which the pectoral fins of mature males develop to create a distinct bell-shaped body not found in females. This particular form of dimorphism is present in each of the <span class="hlt">sister</span> species Leucoraja erinacea and Leucoraja ocellata, but differences between sexes are much greater in the former. In order to understand the nature and potential causes of pectoral dimorphism, we used geometric morphometrics to investigate allometry of fin shape in L. erinacea and L. ocellata and its relationship to the development of reproductive organs, based on previous work on the bonnethead shark, Sphyrna tiburo. We found that allometric trajectories of overall pectoral shape were different in both species of skate, but only L. erinacea varied significantly with respect to endoskeleton development. Male maturation was characterized by a number of sex-specific morphological changes, which appeared concurrently in developmental timing with elongation of cartilage-supported claspers. We suggest that external sexual dimorphism of pectoral fins in skates is a byproduct of skeletal growth needed for clasper development. Further, the magnitude of male shape change appears to be <span class="hlt">linked</span> to the differential life histories of species. This work reports for the first time that pectoral dimorphism is a persistent feature in rajoid fishes, occurring in varying degrees across several genera. Lastly, our results suggest that pectoral morphology may be useful as a relative indicator of reproductive strategy in some species. © 2016 Wiley Periodicals, Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3519633','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3519633"><span>Incestuous <span class="hlt">Sisters</span>: Mate Preference for Brothers over Unrelated Males in Drosophila melanogaster</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Loyau, Adeline; Cornuau, Jérémie H.; Clobert, Jean; Danchin, Étienne</p> <p>2012-01-01</p> <p>The literature is full of examples of inbreeding avoidance, while recent mathematical models predict that inbreeding tolerance or even inbreeding preference should be expected under several realistic conditions like e.g. polygyny. We investigated male and female mate preferences with respect to relatedness in the fruit fly D. melanogaster. Experiments offered the choice between a first order relative (full-sibling or parent) and an unrelated individual with the same age and mating history. We found that females significantly preferred mating with their brothers, thus supporting inbreeding preference. Moreover, females did not avoid mating with their fathers, and males did not avoid mating with their <span class="hlt">sisters</span>, thus supporting inbreeding tolerance. Our experiments therefore add empirical evidence for inbreeding preference, which strengthens the prediction that inbreeding tolerance and preference can evolve under specific circumstances through the positive effects on inclusive fitness. PMID:23251487</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23251487','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23251487"><span>Incestuous <span class="hlt">sisters</span>: mate preference for brothers over unrelated males in Drosophila melanogaster.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Loyau, Adeline; Cornuau, Jérémie H; Clobert, Jean; Danchin, Etienne</p> <p>2012-01-01</p> <p>The literature is full of examples of inbreeding avoidance, while recent mathematical models predict that inbreeding tolerance or even inbreeding preference should be expected under several realistic conditions like e.g. polygyny. We investigated male and female mate preferences with respect to relatedness in the fruit fly D. melanogaster. Experiments offered the choice between a first order relative (full-sibling or parent) and an unrelated individual with the same age and mating history. We found that females significantly preferred mating with their brothers, thus supporting inbreeding preference. Moreover, females did not avoid mating with their fathers, and males did not avoid mating with their <span class="hlt">sisters</span>, thus supporting inbreeding tolerance. Our experiments therefore add empirical evidence for inbreeding preference, which strengthens the prediction that inbreeding tolerance and preference can evolve under specific circumstances through the positive effects on inclusive fitness.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28844823','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28844823"><span>Addressing maternal <span class="hlt">deaths</span> due to violence: the Illinois experience.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Koch, Abigail R; Geller, Stacie E</p> <p>2017-11-01</p> <p>Homicide, suicide, and substance abuse accounted for nearly one fourth of all pregnancy-associated <span class="hlt">deaths</span> in Illinois from 2002 through 2013. Maternal mortality review in Illinois has been primarily focused on obstetric and medical causes and little is known about the circumstances surrounding <span class="hlt">deaths</span> due to homicide, suicide, and substance abuse, if they are pregnancy related, and if the <span class="hlt">deaths</span> are potentially preventable. To address this issue, we implemented a process to form a second statewide maternal mortality review committee for <span class="hlt">deaths</span> due to violence in late 2014. We convened a stakeholder group to accomplish 3 tasks: (1) identify appropriate committee members; (2) identify potential types and sources of information that would be required for a meaningful review of violent maternal <span class="hlt">deaths</span>; and (3) revise the Maternal Mortality Review Form. Because homicide, suicide, and substance abuse are closely <span class="hlt">linked</span> to the social determinants of health, the review committee needed to have a broad membership with expertise in areas not required for obstetric maternal mortality review, including social service and community organizations. Identifying additional sources of information is critical; the state Violent <span class="hlt">Death</span> Reporting System, case management data, and police and autopsy reports provide contextual information that cannot be found in medical records. The stakeholder group revised the Maternal Mortality Review Form to collect information relevant to violent maternal <span class="hlt">deaths</span>, including screening history and psychosocial history. The form guides the maternal mortality review committee for <span class="hlt">deaths</span> due to violence to identify potentially preventable factors relating to the woman, her family, systems of care, the community, the legal system, and the institutional environment. The committee has identified potential opportunities to decrease preventable <span class="hlt">death</span> requiring cooperation with social service agencies and the criminal justice system in addition to the physical</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.usgs.gov/pp/1606/report.pdf','USGSPUBS'); return false;" href="https://pubs.usgs.gov/pp/1606/report.pdf"><span>Debris flows from failures Neoglacial-age moraine dams in the Three <span class="hlt">Sisters</span> and Mount Jefferson wilderness areas, Oregon</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>O'Connor, J. E.; Hardison, J.H.; Costa, J.E.</p> <p>2001-01-01</p> <p>The highest concentration of lakes dammed by Neoglacial moraines in the conterminous United States is in the Mount Jefferson and Three <span class="hlt">Sisters</span> Wilderness Areas in central Oregon. Between 1930 and 1980, breakouts of these lakes have resulted in 11 debris flows. The settings and sequences of events leading to breaching and the downstream flow behavior of the resulting debris flows provide guidance on the likelihood and magnitude of future lake breakouts and debris flows.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24879884','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24879884"><span>Motivations, <span class="hlt">Death</span> Anxiety, and Empathy in Hospice Volunteers in France.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Garbay, Meriem; Gay, Marie-Claire; Claxton-Oldfield, Stephen</p> <p>2015-08-01</p> <p>This study examined the motivations for volunteering of hospice volunteers in France. In addition, their levels of <span class="hlt">death</span> anxiety and empathy were measured and compared with those of French non-hospice volunteers and non-volunteers. Three questionnaires-the Inventory of Motivations for Hospice Palliative Care Volunteerism (IMHPCV), the Templer/McMordie <span class="hlt">Death</span> Anxiety Scale, and the Interpersonal Reactivity Index-were sent via an Internet <span class="hlt">link</span> to 2 hospice volunteer associations and to non-hospice volunteers and non-volunteers (only the hospice volunteers received the IMHPCV). Altruistic motives had the most influence on the respondents' decision to become a hospice volunteer. French hospice volunteers scored significantly lower on 3 categories of motives on the IMHPCV compared to a sample of Canadian hospice palliative care volunteers (study 2), suggesting that cultural differences may be involved. No significant differences were found in levels of <span class="hlt">death</span> anxiety or empathy between the 3 groups of respondents of the study. © The Author(s) 2014.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17889735','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17889735"><span>Siblings' experiences of having a brother or <span class="hlt">sister</span> with autism and mental retardation: a case study of 14 siblings from five families.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Benderix, Ylva; Sivberg, Bengt</p> <p>2007-10-01</p> <p>The aim of this study was to describe the present and past experiences of 14 siblings from five families in terms of having a brother or <span class="hlt">sister</span> with autism and mental retardation. Personal interviews were conducted with the siblings before their brothers or <span class="hlt">sisters</span> were moved to a newly opened group home. Qualitative content analysis was used for the analysis of the transcribed texts. The analysis resulted in seven content categories: precocious responsibility, feeling sorry, exposed to frightening behavior, empathetic feelings, hoping that a group home will be a relief, physical violence made siblings feel unsafe and anxious, and relations with friends were affected negatively. The conclusion is that these siblings' experiences revealed stressful life conditions. Counseling for the family and for siblings is recommended to help them deal with their feelings and problems. For the siblings in these five families, a group home was a relevant alternative as a temporary or permanent placement for the child with autism and mental retardation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3532853','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3532853"><span>Divorce and <span class="hlt">Death</span>: A Case Study for Health Psychology</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sbarra, David A.; Hasselmo, Karen; Nojopranoto, Widyasita</p> <p>2012-01-01</p> <p>Marital separation and divorce are associated with increased risk for early <span class="hlt">death</span>, and the magnitude of this association rivals that of many well-established public health factors. In the case of divorce, however, the mechanisms explaining precisely why and how some people are at risk for early <span class="hlt">death</span> remain unclear. This paper reviews what is known about the association between divorce and risk for all-cause mortality, then discusses four emerging themes in this area of research: the biological intermediaries <span class="hlt">linking</span> divorce to pathophysiology and disease onset, moving beyond the statistical mean, focusing research on the diathesis-stress model, and studying how opportunity foreclosures may place people on a trajectory toward poor distal health outcomes. These ideas are grounded in a set of public lay commentaries about the association between divorce and <span class="hlt">death</span>; in this way, the paper seeks to integrate current research ideas with how the general public thinks about divorce and its correlates. Although this paper focuses on divorce, many of the emerging themes are applicable to the study of psychosocial stress and health more generally. Therefore, the study of divorce and <span class="hlt">death</span> provides a good case study for health psychology and considers new questions that can be pursued in a variety of research areas. PMID:23284588</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23284588','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23284588"><span>Divorce and <span class="hlt">Death</span>: A Case Study for Health Psychology.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sbarra, David A; Hasselmo, Karen; Nojopranoto, Widyasita</p> <p>2012-12-01</p> <p>Marital separation and divorce are associated with increased risk for early <span class="hlt">death</span>, and the magnitude of this association rivals that of many well-established public health factors. In the case of divorce, however, the mechanisms explaining precisely why and how some people are at risk for early <span class="hlt">death</span> remain unclear. This paper reviews what is known about the association between divorce and risk for all-cause mortality, then discusses four emerging themes in this area of research: the biological intermediaries <span class="hlt">linking</span> divorce to pathophysiology and disease onset, moving beyond the statistical mean, focusing research on the diathesis-stress model, and studying how opportunity foreclosures may place people on a trajectory toward poor distal health outcomes. These ideas are grounded in a set of public lay commentaries about the association between divorce and <span class="hlt">death</span>; in this way, the paper seeks to integrate current research ideas with how the general public thinks about divorce and its correlates. Although this paper focuses on divorce, many of the emerging themes are applicable to the study of psychosocial stress and health more generally. Therefore, the study of divorce and <span class="hlt">death</span> provides a good case study for health psychology and considers new questions that can be pursued in a variety of research areas.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3101564','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3101564"><span>A <span class="hlt">Sister</span> Group Contrast Using Untargeted Global Metabolomic Analysis Delineates the Biochemical Regulation Underlying Desiccation Tolerance in Sporobolus stapfianus[C][W][OA</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Oliver, Melvin J.; Guo, Lining; Alexander, Danny C.; Ryals, John A.; Wone, Bernard W.M.; Cushman, John C.</p> <p>2011-01-01</p> <p>Understanding how plants tolerate dehydration is a prerequisite for developing novel strategies for improving drought tolerance. The desiccation-tolerant (DT) Sporobolus stapfianus and the desiccation-sensitive (DS) Sporobolus pyramidalis formed a <span class="hlt">sister</span> group contrast to reveal adaptive metabolic responses to dehydration using untargeted global metabolomic analysis. Young leaves from both grasses at full hydration or at 60% relative water content (RWC) and from S. stapfianus at lower RWCs were analyzed using liquid and gas chromatography <span class="hlt">linked</span> to mass spectrometry or tandem mass spectrometry. Comparison of the two species in the fully hydrated state revealed intrinsic differences between the two metabolomes. S. stapfianus had higher concentrations of osmolytes, lower concentrations of metabolites associated with energy metabolism, and higher concentrations of nitrogen metabolites, suggesting that it is primed metabolically for dehydration stress. Further reduction of the leaf RWC to 60% instigated a metabolic shift in S. stapfianus toward the production of protective compounds, whereas S. pyramidalis responded differently. The metabolomes of S. stapfianus leaves below 40% RWC were strongly directed toward antioxidant production, nitrogen remobilization, ammonia detoxification, and soluble sugar production. Collectively, the metabolic profiles obtained uncovered a cascade of biochemical regulation strategies critical to the survival of S. stapfianus under desiccation. PMID:21467579</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=death&pg=3&id=EJ800335','ERIC'); return false;" href="https://eric.ed.gov/?q=death&pg=3&id=EJ800335"><span>Life Experience with <span class="hlt">Death</span>: Relation to <span class="hlt">Death</span> Attitudes and to the Use of <span class="hlt">Death</span>-Related Memories</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bluck, Susan; Dirk, Judith; Mackay, Michael M.; Hux, Ashley</p> <p>2008-01-01</p> <p>The study examines the relation of <span class="hlt">death</span> experience to <span class="hlt">death</span> attitudes and to autobiographical memory use. Participants (N = 52) completed standard <span class="hlt">death</span> attitude measures and wrote narratives about a <span class="hlt">death</span>-related autobiographical memory and (for comparison) a memory of a low point. Self-ratings of the memory narratives were used to assess their…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24655680','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24655680"><span>What goes around comes back around: life narratives and the significance of the past in Donna Leon's <span class="hlt">Death</span> at La Fenice.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Domínguez-Rué, Emma</p> <p>2014-04-01</p> <p>This paper examines the life narratives of characters in Donna Leon's much-celebrated novel <span class="hlt">Death</span> at La Fenice (1992). In the first of her Brunetti mystery series, Commissario Guido Brunetti investigates the <span class="hlt">death</span> of the renowned conductor Helmut Wellauer, poisoned during a performance of La Traviata at La Fenice. As his investigation progresses, Brunetti discovers dark secrets in the past of the acclaimed Maestro, revealing his dishonesty and cruelty, but, most shockingly, his involvement in a horrendous case of child abuse and <span class="hlt">death</span> by neglect. My analysis will address the role of memory and the significance of the past for the present, as the tragic experiences of the Santina <span class="hlt">sisters</span> in the 1930s become intertwined with those of Wellauer's present wife Elizabeth and her daughter Alexandra. Using literary theory and cultural gerontology as methodological tools, this paper will explore Leon's portrait of the aging process: Wellauer's lack of remorse for his past sins and his inability to cope with impending deafness will be contrasted with the painful account by Wellauer's former lover, the once famous soprano Clemenza Santina, whose narrative response to her traumatic experience renders the past more alive than the present. The significance of memory, as well as the crucial role of life narratives in the personal and cultural construction of identity, will be addressed to interrogate the ways in which our perception of aging can be enriched by literary studies. Copyright © 2014 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4487521','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4487521"><span>Reporting Errors in Siblings’ Survival Histories and Their Impact on Adult Mortality Estimates: Results From a Record Linkage Study in Senegal</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Helleringer, Stéphane; Pison, Gilles; Kanté, Almamy M.; Duthé, Géraldine; Andro, Armelle</p> <p>2014-01-01</p> <p>Estimates of adult mortality in countries with limited vital registration (e.g., sub-Saharan Africa) are often derived from information about the survival of a respondent’s siblings. We evaluated the completeness and accuracy of such data through a record linkage study conducted in Bandafassi, located in southeastern Senegal. We <span class="hlt">linked</span> at the individual level retrospective siblings’ survival histories (SSH) reported by female respondents (n = 268) to prospective mortality data and genealogies collected through a health and demographic surveillance system (HDSS). Respondents often reported inaccurate lists of siblings. Additions to these lists were uncommon, but omissions were frequent: respondents omitted 3.8 % of their live <span class="hlt">sisters</span>, 9.1 % of their deceased <span class="hlt">sisters</span>, and 16.6 % of their <span class="hlt">sisters</span> who had migrated out of the DSS area. Respondents underestimated the age at <span class="hlt">death</span> of the siblings they reported during the interview, particularly among siblings who had died at older ages (≥45 years). Restricting SSH data to person-years and events having occurred during a recent reference period reduced list errors but not age and date errors. Overall, SSH data led to a 20 % underestimate of 45q15 relative to HDSS data. Our study suggests new quality improvement strategies for SSH data and demonstrates the potential use of HDSS data for the validation of “unconventional” demographic techniques. PMID:24493063</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24493063','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24493063"><span>Reporting errors in siblings' survival histories and their impact on adult mortality estimates: results from a record linkage study in Senegal.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Helleringer, Stéphane; Pison, Gilles; Kanté, Almamy M; Duthé, Géraldine; Andro, Armelle</p> <p>2014-04-01</p> <p>Estimates of adult mortality in countries with limited vital registration (e.g., sub-Saharan Africa) are often derived from information about the survival of a respondent's siblings. We evaluated the completeness and accuracy of such data through a record linkage study conducted in Bandafassi, located in southeastern Senegal. We <span class="hlt">linked</span> at the individual level retrospective siblings' survival histories (SSH) reported by female respondents (n = 268) to prospective mortality data and genealogies collected through a health and demographic surveillance system (HDSS). Respondents often reported inaccurate lists of siblings. Additions to these lists were uncommon, but omissions were frequent: respondents omitted 3.8 % of their live <span class="hlt">sisters</span>, 9.1 % of their deceased <span class="hlt">sisters</span>, and 16.6 % of their <span class="hlt">sisters</span> who had migrated out of the DSS area. Respondents underestimated the age at <span class="hlt">death</span> of the siblings they reported during the interview, particularly among siblings who had died at older ages (≥45 years). Restricting SSH data to person-years and events having occurred during a recent reference period reduced list errors but not age and date errors. Overall, SSH data led to a 20 % underestimate of 45 q 15 relative to HDSS data. Our study suggests new quality improvement strategies for SSH data and demonstrates the potential use of HDSS data for the validation of "unconventional" demographic techniques.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26890168','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26890168"><span>Causes and Disparities in <span class="hlt">Death</span> Rates Among Urban American Indian and Alaska Native Populations, 1999-2009.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Jacobs-Wingo, Jasmine L; Espey, David K; Groom, Amy V; Phillips, Leslie E; Haverkamp, Donald S; Stanley, Sandte L</p> <p>2016-05-01</p> <p>To characterize the leading causes of <span class="hlt">death</span> for the urban American Indian/Alaska Native (AI/AN) population and compare with urban White and rural AI/AN populations. We <span class="hlt">linked</span> Indian Health Service patient registration records with the National <span class="hlt">Death</span> Index to reduce racial misclassification in <span class="hlt">death</span> certificate data. We calculated age-adjusted urban AI/AN <span class="hlt">death</span> rates for the period 1999-2009 and compared those with corresponding urban White and rural AI/AN <span class="hlt">death</span> rates. The top-5 leading causes of <span class="hlt">death</span> among urban AI/AN persons were heart disease, cancer, unintentional injury, diabetes, and chronic liver disease and cirrhosis. Compared with urban White persons, urban AI/AN persons experienced significantly higher <span class="hlt">death</span> rates for all top-5 leading causes. The largest disparities were for diabetes and chronic liver disease and cirrhosis. In general, urban and rural AI/AN persons had the same leading causes of <span class="hlt">death</span>, although urban AI/AN persons had lower <span class="hlt">death</span> rates for most conditions. Urban AI/AN persons experience significant disparities in <span class="hlt">death</span> rates compared with their White counterparts. Public health and clinical interventions should target urban AI/AN persons to address behaviors and conditions contributing to health disparities.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ1152989.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ1152989.pdf"><span>Advocating for Health and Safety through Social Media--<span class="hlt">Linked</span> In!</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Carreon, Amie Klein; Peoples, JaNiene; Shipley, Meagan; Wilson, Kelly; Ramirez, Cameron</p> <p>2016-01-01</p> <p>Excessive drinking among college students, which is influenced by an array of factors ranging from campus norms to membership in student organizations, has been <span class="hlt">linked</span> to consequences including motor vehicle accidents, cognitive deficits, arrests, overdoses, assaults, and <span class="hlt">death</span>. Considering the severity of consequences related to drinking,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012PhDT.......336M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012PhDT.......336M"><span>Investigations into the Mechanisms of Cell <span class="hlt">Death</span>: The Common <span class="hlt">Link</span> between Anticancer Nanotherapeutics and Nanotoxicology</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Minocha, Shalini</p> <p></p> <p>Nanotoxicology and anticancer nanotherapeutics are essentially two sides of the same coin. The nanotoxicology discipline deals with the nanoparticle (NP)-induced toxicity and mechanisms of cell <span class="hlt">death</span> in healthy cells, whereas anticancer agents delivered via nano-based approaches aim to induce cell <span class="hlt">death</span> in abnormally proliferating cancer cells. The objectives of the studies presented herein were two-fold; to (a) systematically study the physico-chemical properties and cell <span class="hlt">death</span> mechanisms of model NPs and (b) utilize the knowledge gained from cell <span class="hlt">death</span>-nanotoxicity studies in developing a potentially novel anticancer nanotherapeutic agent. For the first objective, the effect of a distinguishing characteristic, i.e., surface carbon coating on the matched pairs of carbon-coated and non-coated copper and nickel NPs (Cu, C-Cu, Ni and C-Ni) on the physico-chemical properties and toxicity in A549 alveolar epithelial cells were evaluated. The effect of carbon coating on particle size, zeta potential, oxidation state, cellular uptake, release of soluble metal and concentration dependent toxicity of Cu and Ni NPs was systematically evaluated. A significant effect of carbon coating was observed on the physico-chemical properties, interaction with cellular membranes, and overall toxicity of the NPs. C-Cu NPs, compared to Cu NPs, showed four-fold lower release of soluble copper, ten-fold higher cellular uptake and protection against surface oxidation. In toxicity assays, C-Cu NPs induced higher mitochondrial damage than Cu NPs whereas Cu NPs were associated with a significant damage to plasma membrane integrity. Nickel and carbon coated nickel NPs were less toxic compared to Cu and C-Cu NPs. Thus, by studying the effect of carbon coating, correlations between physico-chemical properties and toxicity of NPs were established. The second objective was focused on utilizing nano-based approaches for the intracellular delivery of an anticancer agent, Cytochrome c (Cyt c), to</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21676411','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21676411"><span>Congenital heart disease infant <span class="hlt">death</span> rates decrease as gestational age advances from 34 to 40 weeks.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cnota, James F; Gupta, Resmi; Michelfelder, Erik C; Ittenbach, Richard F</p> <p>2011-11-01</p> <p>To describe congenital heart disease <span class="hlt">death</span> rates in infants born between 34 and 40 weeks, estimate the relationship between gestational age and congenital heart disease infant <span class="hlt">death</span> rates, and compare congenital heart disease <span class="hlt">death</span> rates across 1- and 2-week intervals in gestational age. The 2000 to 2003 national <span class="hlt">linked</span> birth/infant <span class="hlt">death</span> cohort datasets were obtained. Congenital heart disease <span class="hlt">deaths</span> were identified by using International Statistical Classification of Diseases, 10th Revision codes. Proportional <span class="hlt">death</span> rates were calculated by using congenital heart disease <span class="hlt">deaths</span> and all live births. The relationship between congenital heart disease <span class="hlt">death</span> rates and gestational age was determined. <span class="hlt">Death</span> rates were compared across intervals. A total of 14.9 million records were analyzed. Congenital heart disease <span class="hlt">deaths</span> occurred in 4736 infants (0.04%) born between 34 and 40 weeks. There was a significant, negative linear relationship between congenital heart disease <span class="hlt">death</span> rate and gestational age (R(2) = 0.97). Comparisons across 1-week intervals varied (P = .02-.23). All 2-week intervals were statistically significant (P < .01). Congenital heart disease <span class="hlt">death</span> rates decrease as gestational age approaches 40 weeks. These results should be considered before elective delivery for the sole indication of prenatally diagnosed congenital heart disease. Copyright © 2011 Mosby, Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27006427','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27006427"><span>Did <span class="hlt">death</span> certificates and a <span class="hlt">death</span> review process agree on lung cancer cause of <span class="hlt">death</span> in the National Lung Screening Trial?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Marcus, Pamela M; Doria-Rose, Vincent Paul; Gareen, Ilana F; Brewer, Brenda; Clingan, Kathy; Keating, Kristen; Rosenbaum, Jennifer; Rozjabek, Heather M; Rathmell, Joshua; Sicks, JoRean; Miller, Anthony B</p> <p>2016-08-01</p> <p>Randomized controlled trials frequently use <span class="hlt">death</span> review committees to assign a cause of <span class="hlt">death</span> rather than relying on cause of <span class="hlt">death</span> information from <span class="hlt">death</span> certificates. The National Lung Screening Trial, a randomized controlled trial of lung cancer screening with low-dose computed tomography versus chest X-ray for heavy and/or long-term smokers ages 55-74 years at enrollment, used a committee blinded to arm assignment for a subset of <span class="hlt">deaths</span> to determine whether cause of <span class="hlt">death</span> was due to lung cancer. <span class="hlt">Deaths</span> were selected for review using a pre-determined computerized algorithm. The algorithm, which considered cancers diagnosed during the trial, causes and significant conditions listed on the <span class="hlt">death</span> certificate, and the underlying cause of <span class="hlt">death</span> derived from <span class="hlt">death</span> certificate information by trained nosologists, selected <span class="hlt">deaths</span> that were most likely to represent a <span class="hlt">death</span> due to lung cancer (either directly or indirectly) and <span class="hlt">deaths</span> that might have been erroneously assigned lung cancer as the cause of <span class="hlt">death</span>. The algorithm also selected <span class="hlt">deaths</span> that might be due to adverse events of diagnostic evaluation for lung cancer. Using the review cause of <span class="hlt">death</span> as the gold standard and lung cancer cause of <span class="hlt">death</span> as the outcome of interest (dichotomized as lung cancer versus not lung cancer), we calculated performance measures of the <span class="hlt">death</span> certificate cause of <span class="hlt">death</span>. We also recalculated the trial primary endpoint using the <span class="hlt">death</span> certificate cause of <span class="hlt">death</span>. In all, 1642 <span class="hlt">deaths</span> were reviewed and assigned a cause of <span class="hlt">death</span> (42% of the 3877 National Lung Screening Trial <span class="hlt">deaths</span>). Sensitivity of <span class="hlt">death</span> certificate cause of <span class="hlt">death</span> was 91%; specificity, 97%; positive predictive value, 98%; and negative predictive value, 89%. About 40% of the <span class="hlt">deaths</span> reclassified to lung cancer cause of <span class="hlt">death</span> had a <span class="hlt">death</span> certificate cause of <span class="hlt">death</span> of a neoplasm other than lung. Using the <span class="hlt">death</span> certificate cause of <span class="hlt">death</span>, the lung cancer mortality reduction was 18% (95% confidence interval: 4.2-25.0), as</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3502434','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3502434"><span>Colloid cyst of the third ventricle, hypothalamus, and heart: a dangerous <span class="hlt">link</span> for sudden <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2012-01-01</p> <p>Abstract Colloid cysts are rare congenital, intracranial neoplasms, commonly located in the third ventricle. Colloid cysts are endodermal congenital malformations. The cysts commonly range in size from 1–2 cm in diameter, although large cysts >3 cm in size have been reported. The components of the cyst include an outer fibrous capsule over an inner epithelium. The epithelium is usually a single layer of mucin-producing or ciliated cells. Such cysts contain mucoid and gelatinous material, which is positive for both Periodic acid Schiff (PAS) and mucicarmen staining. Although colloid cysts usually represent histopathologically benign neoplasms, they can result in sudden, unexpected and potentially lethal complications. The mechanism(s) of <span class="hlt">death</span> is still a controversial subject and several mechanisms have been postulated to explain the sudden onset of severe symptoms and of fatal rapid deterioration in patients with colloid cysts. In this case, macroscopic and histological findings addressed the diagnosis of colloid cyst of the third ventricle with diffuse myocardial injury (coagulative myocytolysis or contraction band necrosis, CBN) and led us to conclude that acute cardiac arrest due to hypothalamus stimulation in the context of colloid cyst of the third ventricle was the cause of <span class="hlt">death</span>. As the hypothalamic structures which are involved in neuroendocrine and autonomic regulation playing a key role in cardiovascular control are located close to the walls of the third ventricle which is the most frequent anatomical site of colloid cyst, this may suggest that reflex cardiac effects due to the compression of the hypothalamic cardiovascular regulatory centers by the cyst explain the sudden <span class="hlt">death</span> in patients harboring a colloid cyst when signs of hydrocephalus or brain herniation are lacking. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4915842848034158 PMID:23078815</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://rosap.ntl.bts.gov/view/dot/5120','DOTNTL'); return false;" href="https://rosap.ntl.bts.gov/view/dot/5120"><span>Revised catalog of types of CODES applications implemented using <span class="hlt">linked</span> state data : crash outcome data evaluation system (CODES)</span></a></p> <p><a target="_blank" href="http://ntlsearch.bts.gov/tris/index.do">DOT National Transportation Integrated Search</a></p> <p></p> <p>2000-06-01</p> <p>The purpose of the Revised Catalog of Types of CODES Applications Implemented Using <span class="hlt">Linked</span> : State Data (CODES) is to inspire the development of new applications for <span class="hlt">linked</span> data that support : efforts to reduce <span class="hlt">death</span>, disability, severity, and health...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11272746','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11272746"><span>An unusual birthmark case thought to be <span class="hlt">linked</span> to a person who had previously died.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Keil, H H; Tucker, J B</p> <p>2000-12-01</p> <p>The following case report describes a Burmese subject with an unusual birthmark and birth defects thought by local people to be <span class="hlt">linked</span> to events surrounding the <span class="hlt">death</span> of his mother's first husband. The nature of the <span class="hlt">link</span> is explored, including how the assumption of a linkage could have led to subsequent events.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28724668','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28724668"><span>Mortality Rates and Cause of <span class="hlt">Death</span> Among Former Prison Inmates in North Carolina.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Jones, Mark; Kearney, Gregory D; Xu, Xiaohui; Norwood, Tammy; Proescholdbell, Scott K</p> <p>2017-01-01</p> <p>BACKGROUND Inmates face challenges upon release from prison, including increased risk of <span class="hlt">death</span>. We examine mortality among former inmates in North Carolina, including both violent and nonviolent <span class="hlt">deaths</span>. METHODS A retrospective cohort study among former North Carolina inmates released between 2008 and 2010 were <span class="hlt">linked</span> with North Carolina mortality data to determine cause of <span class="hlt">death</span>. Inmates were followed through December 31, 2012. Mortality rates among former inmates were compared with <span class="hlt">deaths</span> among North Carolina residents using standardized mortality ratios (SMRs). RESULTS Among former inmates (N = 41,495), there were 926 <span class="hlt">deaths</span> during the study period. Compared to the North Carolina general population, SMRs were higher for all-cause mortality for total <span class="hlt">deaths</span> (SMR = 2.10, 95% CI: 1.97-2.24), heart disease (SMR = 4.45, 95% CI: 3.64-5.34), cancer (SMR = 3.92, 95% CI: 3.34-4.62), suicide (SMR = 14.46, 95% CI: 10.28-19.76), and homicide (SMR = 7.98, 95% CI: 6.34-10.03). DISCUSSION The <span class="hlt">death</span> rate among former North Carolina inmates is significantly higher than that of other North Carolina residents. Although more research is needed, identifying areas for interventions is essential for reducing the risk of <span class="hlt">death</span> among this population. ©2017 by the North Carolina Institute of Medicine and The Duke Endowment. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1838937','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1838937"><span>Hypoglycemic neuronal <span class="hlt">death</span> is triggered by glucose reperfusion and activation of neuronal NADPH oxidase</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Suh, Sang Won; Gum, Elizabeth T.; Hamby, Aaron M.; Chan, Pak H.; Swanson, Raymond A.</p> <p>2007-01-01</p> <p>Hypoglycemic coma and brain injury are potential complications of insulin therapy. Certain neurons in the hippocampus and cerebral cortex are uniquely vulnerable to hypoglycemic cell <span class="hlt">death</span>, and oxidative stress is a key event in this cell <span class="hlt">death</span> process. Here we show that hypoglycemia-induced oxidative stress and neuronal <span class="hlt">death</span> are attributable primarily to the activation of neuronal NADPH oxidase during glucose reperfusion. Superoxide production and neuronal <span class="hlt">death</span> were blocked by the NADPH oxidase inhibitor apocynin in both cell culture and in vivo models of insulin-induced hypoglycemia. Superoxide production and neuronal <span class="hlt">death</span> were also blocked in studies using mice or cultured neurons deficient in the p47phox subunit of NADPH oxidase. Chelation of zinc with calcium disodium EDTA blocked both the assembly of the neuronal NADPH oxidase complex and superoxide production. Inhibition of the hexose monophosphate shunt, which utilizes glucose to regenerate NADPH, also prevented superoxide formation and neuronal <span class="hlt">death</span>, suggesting a mechanism <span class="hlt">linking</span> glucose reperfusion to superoxide formation. Moreover, the degree of superoxide production and neuronal <span class="hlt">death</span> increased with increasing glucose concentrations during the reperfusion period. These results suggest that high blood glucose concentrations following hypoglycemic coma can initiate neuronal <span class="hlt">death</span> by a mechanism involving extracellular zinc release and activation of neuronal NADPH oxidase. PMID:17404617</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://archive.defense.gov/home/features/2006/al_zarqawi','SCIGOVWS'); return false;" href="http://archive.defense.gov/home/features/2006/al_zarqawi"><span>Defense<span class="hlt">Link</span> Special: Abu Musab Al-Zarqawi Killed in Air Strike</span></a></p> <p><a target="_blank" href="http://www.science.gov/aboutsearch.html">Science.gov Websites</a></p> <p></p> <p></p> <p>Defense<span class="hlt">Link</span>.mil Jun. 11, 2015 War on <em>Terror</em> Transformation News Products Press Resources Images Websites Contact , June 8, 2006 - The <span class="hlt">death</span> of terrorist leader Abu Musab al Zarqawi is a victory in the war on <em>terror</em> and</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/3442830','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/3442830"><span>Indirect intergenic suppression of a radiosensitive mutant of Sordaria macrospora defective in <span class="hlt">sister</span>-chromatid cohesiveness.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Huynh, A D; Leblon, G; Zickler, D</p> <p>1986-01-01</p> <p>Six ultra violet (UV) mutageneses were performed on the spo76 UV-sensitive mutant of Sordaria macrospora. Spo76 shows an early centromere cleavage associated with an arrest at the first meiotic division and therefore does not form ascospores. Moreover, it exhibits altered pairing structure (synaptonemal complex), revealing a defect in the <span class="hlt">sister</span>-chromatid cohesiveness. From 37 revertants which partially restored sporulation, 34 extragenic suppressors of spo76 were isolated. All suppressors are altered in chromosomal pairing but, unlike spo76, show a wild type centromere cleavage. The 34 suppressors were assigned to six different genes and mapped. Only one of the suppressor genes is involved in repair functions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5328110','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5328110"><span>Drowning <span class="hlt">deaths</span> between 1861 and 2000 in Victoria, Australia</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ozanne-Smith, Joan</p> <p>2017-01-01</p> <p>Abstract Objective To identify the long-term patterns of drowning mortality in the state of Victoria, Australia, and to describe the historical context in which the decrease occurred. Methods We obtained data on drowning <span class="hlt">deaths</span> and population statistics from the Australian Bureau of Statistics and its predecessors for the period 1861 to 2000. From these data, we calculated drowning <span class="hlt">death</span> rates per 100 000 population per year, by gender and age. We reviewed primary and secondary historical resources, such as government and newspaper archives, books and the Internet, to identify changes or events in the state that may have affected drowning mortality. Findings From 1861 to 2000, at least 18 070 people drowned in Victoria. Male drowning rates were higher than those for females in all years and for all ages. Both sexes experienced the highest drowning rate in 1863 (79.5 male <span class="hlt">deaths</span> per 100 000 population and 18.8 female <span class="hlt">death</span> per 100 000 population). The lowest drowning rate was documented in 2000 (1.4 male <span class="hlt">deaths</span> per 100 000 population and 0.3 female <span class="hlt">deaths</span> per 100 000 population). The reduction patterns of drowning mortality occurred within a historical context of factors that directly affected drowning mortality, such as the improvement in people’s water safety skills, or those that incidentally affected drowning mortality, like infrastructure development. Conclusion We identified patterns of reduction in drowning mortality, both in males and females and across age groups. These patterns could be <span class="hlt">linked</span> to events and factors that happened in Victoria during this period. These findings may have relevance to current developing communities. PMID:28250530</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/978251-increase-telomere-sister-chromatid-exchange-murine-embryonic-stem-cells-possessing-critically-shortened-telomeres','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/978251-increase-telomere-sister-chromatid-exchange-murine-embryonic-stem-cells-possessing-critically-shortened-telomeres"><span>An increase in telomere <span class="hlt">sister</span> chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Wang, Yisong; Giannone, Richard J; Wu, Jun</p> <p></p> <p>Telomerase deficiency leads to a progressive loss of telomeric DNA that eventually triggers cell apoptosis in human primary cells during prolonged growth in culture. Rare survivors can maintain telomere length through either activation of telomerase or recombination-based telomere lengthening, and thus proliferate indefinitely. We have explored the possibility that telomeres may be maintained through telomere <span class="hlt">sister</span> chromatid exchange (T-SCE) in murine telomere reverse transcriptase-deficient (mTert -/-) splenocytes and ES cells. Because telomerase deficiency leads to gradual loss of telomeric DNA in mTert -/- splenocytes and ES cells and eventually to chromosomes with telomere signal-free ends (SFEs), we examined these cellmore » types for evidence of <span class="hlt">sister</span> chromatid exchange at telomeres, and observed an increase in T-SCEs only in a subset of mTert -/- splenocytes or ES cells that possessed multiple SFEs. Furthermore, T-SCEs were more often detected in ES cells than in splenocytes that harbored a similar frequency of SFEs. In mTert heterozygous (mTert +/-) ES cells or splenocytes, which are known to exhibit a decrease in average telomere length but no SFEs, no increase in T-SCE was observed. In addition to T-SCE, other genomic rearrangements (i.e., SCE) were also significantly increased in mTert -/- ES cells possessing critically short telomeres, but not in splenocytes. Our results suggest that animals and cell culture differ in their ability to carry out genomic rearrangements as a means of maintaining telomere integrity when telomeres become critically shortened.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23472324','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23472324"><span>Quality insights of university teachers on dying, <span class="hlt">death</span>, and <span class="hlt">death</span> education.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mak, Mui-Hing June</p> <p></p> <p>One of the main responsibilities of teachers is to help individual students cope with life difficulties such as grief following a <span class="hlt">death</span>. However, very little research explores teachers' views on <span class="hlt">death</span>, dying, and how they handle grief and loss in schools. This study aims to explore university teachers' knowledge and attitudes on dying, <span class="hlt">death</span>, and <span class="hlt">death</span> education. Fifteen university teachers were recruited using a qualitative method. This study reveals that most teachers' views on <span class="hlt">death</span> and related issues are largely affected by their <span class="hlt">death</span> experiences, religious beliefs, professional background, and the mass media. Although they have a general negative response toward <span class="hlt">death</span> and dying, some teachers begin to affirm their meanings of life and <span class="hlt">death</span>. Most teachers agree that they do not feel adequate about managing and teaching on life and <span class="hlt">death</span> issues, so they strongly support including <span class="hlt">death</span> education in the formal programs in Hong Kong.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5882101','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5882101"><span>Detection of <span class="hlt">sister</span>-species in invasive populations of the fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae) from Uganda</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Tay, Wee Tek; Walsh, Thomas K.; Kanyesigye, Dalton; Adumo, Stella; Abongosi, Joseph; Ochen, Stephen; Sserumaga, Julius; Alibu, Simon; Abalo, Grace; Asea, Godfrey; Agona, Ambrose</p> <p>2018-01-01</p> <p>The fall armyworm (FAW) Spodoptera frugiperda (J. E. Smith) is a species native to the Americas. This polyphagous lepidopteran pest was first reported in Nigeria and the Democratic Republic of São Tomé and Principe in 2016, but its presence in eastern Africa has not been confirmed via molecular characterisation. In this study, FAW specimens from western and central Uganda were identified based on the partial mtDNA COI gene sequences, with mtDNA COI haplotypes matching those identified in Nigeria and São Tomé. In this study, we sequence an additional partial mtDNA Cyt b gene and also the partial mtDNA COIII gene in Ugandan FAW samples. We detected identical mitochondrial DNA haplotypes for both the mtDNA Cyt b and COI partial genes, while combining the mtDNA COI/Cyt b haplotypes and mtDNA COIII haplotypes enabled a new maternal lineage in the Ugandan corn-preferred FAW samples to be identified. Our results suggested that the African incursions of S. frugiperda involved at least three maternal lineages. Recent full genome, phylogenetic and microsatellite analyses provided evidence to support S. frugiperda as likely consisted of two sympatric <span class="hlt">sister</span> species known as the corn-preferred and rice-preferred strains. In our Ugandan FAW populations, we identified the presence of mtDNA haplotypes representative of both <span class="hlt">sister</span> species. It is not known if both FAW <span class="hlt">sister</span> species were originally introduced together or separately, and whether they have since spread as a single population. Further analyses of additional specimens originally collected from São Tomé, Nigeria and throughout Africa would be required to clarify this issue. Importantly, our finding showed that the genetic diversity of the African corn-preferred FAW species is higher than previously reported. This potentially contributed to the success of FAW establishment in Africa. Furthermore, with the additional maternal lineages detected, there is likely an increase in paternal lineages, thereby increasing</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29614067','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29614067"><span>Detection of <span class="hlt">sister</span>-species in invasive populations of the fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae) from Uganda.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Otim, Michael H; Tay, Wee Tek; Walsh, Thomas K; Kanyesigye, Dalton; Adumo, Stella; Abongosi, Joseph; Ochen, Stephen; Sserumaga, Julius; Alibu, Simon; Abalo, Grace; Asea, Godfrey; Agona, Ambrose</p> <p>2018-01-01</p> <p>The fall armyworm (FAW) Spodoptera frugiperda (J. E. Smith) is a species native to the Americas. This polyphagous lepidopteran pest was first reported in Nigeria and the Democratic Republic of São Tomé and Principe in 2016, but its presence in eastern Africa has not been confirmed via molecular characterisation. In this study, FAW specimens from western and central Uganda were identified based on the partial mtDNA COI gene sequences, with mtDNA COI haplotypes matching those identified in Nigeria and São Tomé. In this study, we sequence an additional partial mtDNA Cyt b gene and also the partial mtDNA COIII gene in Ugandan FAW samples. We detected identical mitochondrial DNA haplotypes for both the mtDNA Cyt b and COI partial genes, while combining the mtDNA COI/Cyt b haplotypes and mtDNA COIII haplotypes enabled a new maternal lineage in the Ugandan corn-preferred FAW samples to be identified. Our results suggested that the African incursions of S. frugiperda involved at least three maternal lineages. Recent full genome, phylogenetic and microsatellite analyses provided evidence to support S. frugiperda as likely consisted of two sympatric <span class="hlt">sister</span> species known as the corn-preferred and rice-preferred strains. In our Ugandan FAW populations, we identified the presence of mtDNA haplotypes representative of both <span class="hlt">sister</span> species. It is not known if both FAW <span class="hlt">sister</span> species were originally introduced together or separately, and whether they have since spread as a single population. Further analyses of additional specimens originally collected from São Tomé, Nigeria and throughout Africa would be required to clarify this issue. Importantly, our finding showed that the genetic diversity of the African corn-preferred FAW species is higher than previously reported. This potentially contributed to the success of FAW establishment in Africa. Furthermore, with the additional maternal lineages detected, there is likely an increase in paternal lineages, thereby increasing</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18794530','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18794530"><span>Newly discovered <span class="hlt">sister</span> lineage sheds light on early ant evolution.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rabeling, Christian; Brown, Jeremy M; Verhaagh, Manfred</p> <p>2008-09-30</p> <p>Ants are the world's most conspicuous and important eusocial insects and their diversity, abundance, and extreme behavioral specializations make them a model system for several disciplines within the biological sciences. Here, we report the discovery of a new ant that appears to represent the <span class="hlt">sister</span> lineage to all extant ants (Hymenoptera: Formicidae). The phylogenetic position of this cryptic predator from the soils of the Amazon rainforest was inferred from several nuclear genes, sequenced from a single leg. Martialis heureka (gen. et sp. nov.) also constitutes the sole representative of a new, morphologically distinct subfamily of ants, the Martialinae (subfam. nov.). Our analyses have reduced the likelihood of long-branch attraction artifacts that have troubled previous phylogenetic studies of early-diverging ants and therefore solidify the emerging view that the most basal extant ant lineages are cryptic, hypogaeic foragers. On the basis of morphological and phylogenetic evidence we suggest that these specialized subterranean predators are the sole surviving representatives of a highly divergent lineage that arose near the dawn of ant diversification and have persisted in ecologically stable environments like tropical soils over great spans of time.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2567467','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2567467"><span>Newly discovered <span class="hlt">sister</span> lineage sheds light on early ant evolution</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Rabeling, Christian; Brown, Jeremy M.; Verhaagh, Manfred</p> <p>2008-01-01</p> <p>Ants are the world's most conspicuous and important eusocial insects and their diversity, abundance, and extreme behavioral specializations make them a model system for several disciplines within the biological sciences. Here, we report the discovery of a new ant that appears to represent the <span class="hlt">sister</span> lineage to all extant ants (Hymenoptera: Formicidae). The phylogenetic position of this cryptic predator from the soils of the Amazon rainforest was inferred from several nuclear genes, sequenced from a single leg. Martialis heureka (gen. et sp. nov.) also constitutes the sole representative of a new, morphologically distinct subfamily of ants, the Martialinae (subfam. nov.). Our analyses have reduced the likelihood of long-branch attraction artifacts that have troubled previous phylogenetic studies of early-diverging ants and therefore solidify the emerging view that the most basal extant ant lineages are cryptic, hypogaeic foragers. On the basis of morphological and phylogenetic evidence we suggest that these specialized subterranean predators are the sole surviving representatives of a highly divergent lineage that arose near the dawn of ant diversification and have persisted in ecologically stable environments like tropical soils over great spans of time. PMID:18794530</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4199692','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4199692"><span>Regulation of Centromere Localization of the Drosophila Shugoshin MEI-S332 and <span class="hlt">Sister</span>-Chromatid Cohesion in Meiosis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nogueira, Cristina; Kashevsky, Helena; Pinto, Belinda; Clarke, Astrid; Orr-Weaver, Terry L.</p> <p>2014-01-01</p> <p>The Shugoshin (Sgo) protein family helps to ensure proper chromosome segregation by protecting cohesion at the centromere by preventing cleavage of the cohesin complex. Some Sgo proteins also influence other aspects of kinetochore-microtubule attachments. Although many Sgo members require Aurora B kinase to localize to the centromere, factors controlling delocalization are poorly understood and diverse. Moreover, it is not clear how Sgo function is inactivated and whether this is distinct from delocalization. We investigated these questions in Drosophila melanogaster, an organism with superb chromosome cytology to monitor Sgo localization and quantitative assays to test its function in <span class="hlt">sister</span>-chromatid segregation in meiosis. Previous research showed that in mitosis in cell culture, phosphorylation of the Drosophila Sgo, MEI-S332, by Aurora B promotes centromere localization, whereas Polo phosphorylation promotes delocalization. These studies also suggested that MEI-S332 can be inactivated independently of delocalization, a conclusion supported here by localization and function studies in meiosis. Phosphoresistant and phosphomimetic mutants for the Aurora B and Polo phosphorylation sites were examined for effects on MEI-S332 localization and chromosome segregation in meiosis. Strikingly, MEI-S332 with a phosphomimetic mutation in the Aurora B phosphorylation site prematurely dissociates from the centromeres in meiosis I. Despite the absence of MEI-S332 on meiosis II centromeres in male meiosis, <span class="hlt">sister</span> chromatids segregate normally, demonstrating that detectable levels of this Sgo are not essential for chromosome congression, kinetochore biorientation, or spindle assembly. PMID:25081981</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22351568','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22351568"><span>Psychological health in siblings who lost a brother or <span class="hlt">sister</span> to cancer 2 to 9 years earlier.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Eilegård, Alexandra; Steineck, Gunnar; Nyberg, Tommy; Kreicbergs, Ulrika</p> <p>2013-03-01</p> <p>The objective of this study was to assess long-term psychological distress in siblings who lost a brother or <span class="hlt">sister</span> to cancer 2 to 9 years earlier, as compared with a control group of non-bereaved siblings from the general population. During 2009, we conducted a nationwide follow-up study in Sweden by using an anonymous study-specific questionnaire. Siblings who had lost a brother or <span class="hlt">sister</span> to cancer between the years 2000 and 2007 and also a control group of non-bereaved siblings from the general population were invited to participate. The Hospital Anxiety and Depression Scale (HADS) was used to measure psychological distress, and to test for differences in the ordinal outcome responses between the groups, we used Wilcoxon-Mann-Whitney rank-sum test. Among the bereaved siblings, 174/240 (73%) participated and 219/293 (75%) among the non-bereaved. Self-assessed low self-esteem (p = 0.002), difficulties falling asleep (p = 0.005), and low level of personal maturity (p = 0.007) at follow-up were more prevalent among bereaved siblings. However, anxiety (p = 0.298) and depression (p = 0.946), according to HADS, were similar. Bereaved siblings are at increased risk of low self-esteem, low level of personal maturity and difficulties falling asleep as compared with non-bereaved peers. Yet, the bereaved were not more likely to report anxiety or depression. Copyright © 2012 John Wiley & Sons, Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20457616','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20457616"><span><span class="hlt">Death</span> revisited: rethinking <span class="hlt">death</span> and the dead donor rule.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Iltis, Ana Smith; Cherry, Mark J</p> <p>2010-06-01</p> <p>Traditionally, people were recognized as being dead using cardio-respiratory criteria: individuals who had permanently stopped breathing and whose heart had permanently stopped beating were dead. Technological developments in the middle of the twentieth century and the advent of the intensive care unit made it possible to sustain cardio-respiratory and other functions in patients with severe brain injury who previously would have lost such functions permanently shortly after sustaining a brain injury. What could and should physicians caring for such patients do? Significant advances in human organ transplantation also played direct and indirect roles in discussions regarding the care of such patients. Because successful transplantation requires that organs be removed from cadavers shortly after <span class="hlt">death</span> to avoid organ damage due to loss of oxygen, there has been keen interest in knowing precisely when people are dead so that organs could be removed. Criteria for declaring <span class="hlt">death</span> using neurological criteria developed, and today a whole brain definition of <span class="hlt">death</span> is widely used and recognized by all 50 states in the United States as an acceptable way to determine <span class="hlt">death</span>. We explore the ongoing debate over definitions of <span class="hlt">death</span>, particularly over brain <span class="hlt">death</span> or <span class="hlt">death</span> determined using neurological criteria, and the relationship between definitions of <span class="hlt">death</span> and organ transplantation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12787819','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12787819"><span><span class="hlt">Sister</span> chromatid exchanges and micronuclei analysis in lymphocytes of men exposed to simazine through drinking water.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Suárez, Susanna; Rubio, Arantxa; Sueiro, Rosa Ana; Garrido, Joaquín</p> <p>2003-06-06</p> <p>In some cities of the autonomous community of Extremadura (south-west of Spain), levels of simazine from 10 to 30 ppm were detected in tap water. To analyse the possible effect of this herbicide, two biomarkers, <span class="hlt">sister</span> chromatid exchanges (SCE) and micronuclei (MN), were used in peripheral blood lymphocytes from males exposed to simazine through drinking water. SCE and MN analysis failed to detect any statistically significant increase in the people exposed to simazine when compared with the controls. With respect to high frequency cells (HFC), a statistically significant difference was detected between exposed and control groups.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3435291','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3435291"><span>Distinct Effects of Rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on Cellular Bioenergetics and Cell <span class="hlt">Death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Giordano, Samantha; Lee, Jisun; Darley-Usmar, Victor M.; Zhang, Jianhua</p> <p>2012-01-01</p> <p>Parkinson’s disease is characterized by dopaminergic neurodegeneration and is associated with mitochondrial dysfunction. The bioenergetic susceptibility of dopaminergic neurons to toxins which induce Parkinson’s like syndromes in animal models is then of particular interest. For example, rotenone, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its active metabolite 1-methyl-4-phenylpyridinium (MPP+), and 6-hydroxydopamine (6-OHDA), have been shown to induce dopaminergic cell <span class="hlt">death</span> in vivo and in vitro. Exposure of animals to these compounds induce a range of responses characteristics of Parkinson’s disease, including dopaminergic cell <span class="hlt">death</span>, and Reactive Oxygen Species (ROS) production. Here we test the hypothesis that cellular bioenergetic dysfunction caused by these compounds correlates with induction of cell <span class="hlt">death</span> in differentiated dopaminergic neuroblastoma SH-SY5Y cells. At increasing doses, rotenone induced significant cell <span class="hlt">death</span> accompanied with caspase 3 activation. At these concentrations, rotenone had an immediate inhibition of mitochondrial basal oxygen consumption rate (OCR) concomitant with a decrease of ATP-<span class="hlt">linked</span> OCR and reserve capacity, as well as a stimulation of glycolysis. MPP+ exhibited a different behavior with less pronounced cell <span class="hlt">death</span> at doses that nearly eliminated basal and ATP-<span class="hlt">linked</span> OCR. Interestingly, MPP+, unlike rotenone, stimulated bioenergetic reserve capacity. The effects of 6-OHDA on bioenergetic function was markedly less than the effects of rotenone or MPP+ at cytotoxic doses, suggesting a mechanism largely independent of bioenergetic dysfunction. These studies suggest that these dopaminergic neurotoxins induce cell <span class="hlt">death</span> through distinct mechanisms and differential effects on cellular bioenergetics. PMID:22970265</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22458530-nuclear-damp-complex-mediated-rage-dependent-macrophage-celldeath','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22458530-nuclear-damp-complex-mediated-rage-dependent-macrophage-celldeath"><span>Nuclear DAMP complex-mediated RAGE-dependent macrophage cell <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Chen, Ruochan; Department of Infectious Diseases and State Key Lab of Viral Hepatitis, Xiangya Hospital, Central South University, Changsha, Hunan 410008; Fu, Sha</p> <p></p> <p>High mobility group box 1 (HMGB1), histone, and DNA are essential nuclear components involved in the regulation of chromosome structure and function. In addition to their nuclear function, these molecules act as damage-associated molecular patterns (DAMPs) alone or together when released extracellularly. The synergistic effect of these nuclear DNA-HMGB1-histone complexes as DAMP complexes (nDCs) on immune cells remains largely unexplored. Here, we demonstrate that nDCs limit survival of macrophages (e.g., RAW264.7 and peritoneal macrophages) but not cancer cells (e.g., HCT116, HepG2 and Hepa1-6). nDCs promote production of inflammatory tumor necrosis factor α (TNFα) release, triggering reactive oxygen species-dependent apoptosis andmore » necrosis. Moreover, the receptor for advanced glycation end products (RAGE), but not toll-like receptor (TLR)-4 and TLR-2, was required for Akt-dependent TNFα release and subsequent cell <span class="hlt">death</span> following treatment with nDCs. Genetic depletion of RAGE by RNAi, antioxidant N-Acetyl-L-cysteine, and TNFα neutralizing antibody significantly attenuated nDC-induced cell <span class="hlt">death</span>. These findings provide evidence supporting novel signaling mechanisms <span class="hlt">linking</span> nDCs and inflammation in macrophage cell <span class="hlt">death</span>. - Highlights: • Nuclear DAMP complexes (nDCs) selectively induce cell <span class="hlt">death</span> in macrophages, but not cancer cells. • TNFα-mediated oxidative stress is required for nDC-induced <span class="hlt">death</span>. • RAGE-mediated Akt activation is required for nDC-induced TNFα release. • Blocking RAGE and TNFα inhibits nDC-induced macrophage cell <span class="hlt">death</span>.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2752195','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2752195"><span>Phylogenetic Analysis of Seven WRKY Genes across the Palm Subtribe Attaleinae (Arecaceae) Identifies Syagrus as <span class="hlt">Sister</span> Group of the Coconut</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Meerow, Alan W.; Noblick, Larry; Borrone, James W.; Couvreur, Thomas L. P.; Mauro-Herrera, Margarita; Hahn, William J.; Kuhn, David N.; Nakamura, Kyoko; Oleas, Nora H.; Schnell, Raymond J.</p> <p>2009-01-01</p> <p>Background The Cocoseae is one of 13 tribes of Arecaceae subfam. Arecoideae, and contains a number of palms with significant economic importance, including the monotypic and pantropical Cocos nucifera L., the coconut, the origins of which have been one of the “abominable mysteries” of palm systematics for decades. Previous studies with predominantly plastid genes weakly supported American ancestry for the coconut but ambiguous <span class="hlt">sister</span> relationships. In this paper, we use multiple single copy nuclear loci to address the phylogeny of the Cocoseae subtribe Attaleinae, and resolve the closest extant relative of the coconut. Methodology/Principal Findings We present the results of combined analysis of DNA sequences of seven WRKY transcription factor loci across 72 samples of Arecaceae tribe Cocoseae subtribe Attaleinae, representing all genera classified within the subtribe, and three outgroup taxa with maximum parsimony, maximum likelihood, and Bayesian approaches, producing highly congruent and well-resolved trees that robustly identify the genus Syagrus as <span class="hlt">sister</span> to Cocos and resolve novel and well-supported relationships among the other genera of the Attaleinae. We also address incongruence among the gene trees with gene tree reconciliation analysis, and assign estimated ages to the nodes of our tree. Conclusions/Significance This study represents the as yet most extensive phylogenetic analyses of Cocoseae subtribe Attaleinae. We present a well-resolved and supported phylogeny of the subtribe that robustly indicates a <span class="hlt">sister</span> relationship between Cocos and Syagrus. This is not only of biogeographic interest, but will also open fruitful avenues of inquiry regarding evolution of functional genes useful for crop improvement. Establishment of two major clades of American Attaleinae occurred in the Oligocene (ca. 37 MYBP) in Eastern Brazil. The divergence of Cocos from Syagrus is estimated at 35 MYBP. The biogeographic and morphological congruence that we see for</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA495800','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA495800"><span>Lysosome-mediated Cell <span class="hlt">Death</span> and Autophagy-Dependent Multidrug Resistance in Breast Cancer</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2008-10-01</p> <p>gene <span class="hlt">links</span> mitochondria and cell <span class="hlt">death</span>, the data suggests that Bcl2 may be involved in autophagic cell <span class="hlt">death</span> and AD-MDR. GeneGo analysis also...GSK3 beta GSK3 beta E2A p53 p21 p21 E2F1 PPAR -gamma JNK1(MA PK8) JNK1(M APK8) ESR1 (nuclear) RARalpha Androgen receptor Androge n receptor p53...RelA (p65 NF-kB subunit) Erk (MAPK1/3 ) Erk (MAPK1/ 3) PPAR - gamma SOX9 Bcl-2 Bcl-2 RARalpha SP1 EGFR EGFR RelA (p65 NF- kB subunit) RARalpha RelA</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70024793','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70024793"><span>Magmatic activity beneath the quiescent Three <span class="hlt">Sisters</span> volcanic center, central Oregon Cascade Range, USA</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Wicks, Charles W.; Dzurisin, Daniel; Ingebritsen, Steven E.; Thatcher, Wayne R.; Lu, Zhong; Iverson, Justin</p> <p>2002-01-01</p> <p>Images from satellite interferometric synthetic aperture radar (InSAR) reveal uplift of a broad ~10 km by 20 km area in the Three <span class="hlt">Sisters</span> volcanic center of the central Oregon Cascade Range, ~130 km south of Mt. St. Helens. The last eruption in the volcanic center occurred ~1500 years ago. Multiple satellite images from 1992 through 2000 indicate that most if not all of ~100 mm of observed uplift occurred between September 1998 and October 2000. Geochemical (water chemistry) anomalies, first noted during 1990, coincide with the area of uplift and suggest the existence of a crustal magma reservoir prior to the uplift. We interpret the uplift as inflation caused by an ongoing episode of magma intrusion at a depth of ~6.5 km.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26106145','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26106145"><span>Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Narayanan, Kannan Badri; Ali, Manaf; Barclay, Barry J; Cheng, Qiang Shawn; D'Abronzo, Leandro; Dornetshuber-Fleiss, Rita; Ghosh, Paramita M; Gonzalez Guzman, Michael J; Lee, Tae-Jin; Leung, Po Sing; Li, Lin; Luanpitpong, Suidjit; Ratovitski, Edward; Rojanasakul, Yon; Romano, Maria Fiammetta; Romano, Simona; Sinha, Ranjeet K; Yedjou, Clement; Al-Mulla, Fahd; Al-Temaimi, Rabeah; Amedei, Amedeo; Brown, Dustin G; Ryan, Elizabeth P; Colacci, Annamaria; Hamid, Roslida A; Mondello, Chiara; Raju, Jayadev; Salem, Hosni K; Woodrick, Jordan; Scovassi, A Ivana; Singh, Neetu; Vaccari, Monica; Roy, Rabindra; Forte, Stefano; Memeo, Lorenzo; Kim, Seo Yun; Bisson, William H; Lowe, Leroy; Park, Hyun Ho</p> <p>2015-06-01</p> <p>Cell <span class="hlt">death</span> is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular <span class="hlt">death</span> is tightly <span class="hlt">linked</span> to cancer progression. Specifically, the up-regulation of pro-survival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of pro-apoptotic factors, including tumor suppressive factors, confers resistance to cell <span class="hlt">death</span> in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell <span class="hlt">death</span>, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10846376','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10846376"><span>Discrimination and instructional comprehension: guided discretion, racial bias, and the <span class="hlt">death</span> penalty.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lynch, M; Haney, C</p> <p>2000-06-01</p> <p>This study <span class="hlt">links</span> two previously unrelated lines of research: the lack of comprehension of capital penalty-phase jury instructions and discriminatory <span class="hlt">death</span> sentencing. Jury-eligible subjects were randomly assigned to view one of four versions of a simulated capital penalty trial in which the race of defendant (Black or White) and the race of victim (Black or White) were varied orthogonally. Dependent measures included a sentencing verdict (life without the possibility of parole or the <span class="hlt">death</span> penalty), ratings of penalty phase evidence, and a test of instructional comprehension. Results indicated that instructional comprehension was poor overall and that, although Black defendants were treated only slightly more punitively than White defendants in general, discriminatory effects were concentrated among participants whose comprehension was poorest. In addition, the use of penalty phase evidence differed as a function of race of defendant and whether the participant sentenced the defendant to life or <span class="hlt">death</span>. The study suggest that racially biased and capricious <span class="hlt">death</span> sentencing may be in part caused or exacerbated by the inability to comprehend penalty phase instructions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16104108','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16104108"><span>[Cause of <span class="hlt">death</span>: from primary disease to direct cause of <span class="hlt">death</span>].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Oppewal, F; Smedts, F M M; Meyboom-de Jong, B</p> <p>2005-07-23</p> <p>Following the <span class="hlt">death</span> of a patient, the treating physician in the Netherlands is required to fill out two forms. Form A, which is the certificate of <span class="hlt">death</span> and Form B, which is used by the Statistics Netherlands to compile data on causes ofdeath. The latter form often poses difficulty for the physician with respect to the primary cause of <span class="hlt">death</span>. This applies particularly to cases of sudden <span class="hlt">death</span>, which account for one third of all <span class="hlt">deaths</span> in the Netherlands. As a result, the statistical analyses appear to lead to an incorrect representation of the distribution of causes of <span class="hlt">death</span>. A more thorough investigation into the primary cause of <span class="hlt">death</span> is desirable, if necessary, supported by a request for an autopsy. The primary cause of <span class="hlt">death</span> is to be regarded as the basic disease from which the cascade of changes ultimately leading to <span class="hlt">death</span> originated.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24600720','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24600720"><span>Exploring children's understanding of <span class="hlt">death</span>: through drawings and the <span class="hlt">Death</span> Concept Questionnaire.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bonoti, Fotini; Leondari, Angeliki; Mastora, Adelais</p> <p>2013-01-01</p> <p>To investigate whether children's understanding of the concept of <span class="hlt">death</span> varies as a function of <span class="hlt">death</span> experience and age, 52 children aged 7, 9, and 11 years (26 had a personal <span class="hlt">death</span> experience), drew a picture reflecting the meaning of the word <span class="hlt">death</span> and completed the <span class="hlt">Death</span> Concept Questionnaire for examination of Human and Animal <span class="hlt">Death</span>. The results showed that the 2 methodological tools used offered complementary information and that children's understanding of <span class="hlt">death</span> is related both to age and past experience. Children with <span class="hlt">death</span> experience seem to have a more realistic understanding of <span class="hlt">death</span> than their inexperienced age-mates. As regards to the effect of age, our findings support the assumption that the different components of <span class="hlt">death</span> develop through different processes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25456618','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25456618"><span>Challenging stereotypes? The older woman in the TV series Brothers & <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Oró-Piqueras, Maricel</p> <p>2014-12-01</p> <p>The TV series, Brothers & <span class="hlt">Sisters</span>, broadcast from 2006 to 2011 by ABC (USA) and a year later by Channel 4 (UK) with quite high audience rates, starts when the patriarchal figure, William Walker, dies of a heart attack and two female figures around their sixties come center stage: his wife, Nora Walker, and his long-term lover, Holly Harper. Once the patriarchal figure disappears, the female characters regain visibility by entering the labor market and starting relationships with other men. In that sense, both protagonists experience aging as a time in which they are increasingly freed from social and family constraints. However, their roles as nurturers keep on bringing them back to the domestic space in which they are safe from being involved in uncomfortable and unsuitable situations. Drawing on previous studies on the representation of the older woman in fictional media, this article intends to discern to what extent stereotypes related to the older woman are challenged through the two main protagonists of a contemporary TV series. Copyright © 2014 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5175461','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5175461"><span>High use of complementary and alternative medicine among a large cohort of women with a family history of breast cancer: The <span class="hlt">Sister</span> Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Greenlee, Heather; Molmenti, Christine Sardo; Falci, Laura; Ulmer, Ross; Deming-Halverson, Sandra; DeRoo, Lisa A.; Sandler, Dale P.</p> <p>2016-01-01</p> <p>Purpose Use of complementary and alternative medicine (CAM) is high among U.S. women, yet information is limited on use among women at increased breast cancer risk. We analyzed CAM use among women with a family history of breast cancer. Methods CAM use was analyzed among women enrolled 2003–2009 in the <span class="hlt">Sister</span> Study cohort. Eligible women were age 35–74, U.S. or Puerto Rican residents, no personal history of breast cancer, and had ≥1 <span class="hlt">sister</span> with breast cancer. Baseline data on CAM use in the past year was available for 49,734 women. Logistic regression models examined the association between CAM use and Gail Model breast cancer risk score. Results were compared to female participants in the 2007 National Health Interview Survey (n=7,965). Results Among <span class="hlt">Sister</span> Study participants, there was high use of vitamin/mineral supplements (78.8%), mind/body practices (41.4%), manipulative/body-based practices (31.5%), and botanicals (22.8%). Overall use was higher than the U.S. female population. No association was observed between familial breast cancer risk and CAM use. Black women were more likely to use spirituality/meditation-based CAM modalities, while non-Hispanic white and Asian women were high users of dietary supplements. Conclusions In a cohort of women with increased breast cancer risk due to family history, CAM use is higher than women in the general U.S. population and is associated with race/ethnicity. Use was not associated with breast cancer risk. Given the high prevalence of CAM use among women at risk for breast caner, research on the effectiveness of CAM use for disease prevention is needed. PMID:27017506</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28497238','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28497238"><span>Obesity-related mortality in France, Italy, and the United States: a comparison using multiple cause-of-<span class="hlt">death</span> analysis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Barbieri, Magali; Désesquelles, Aline; Egidi, Viviana; Demuru, Elena; Frova, Luisa; Meslé, France; Pappagallo, Marilena</p> <p>2017-07-01</p> <p>We investigate the reporting of obesity on <span class="hlt">death</span> certificates in three countries (France, Italy, and the United States) with different levels of prevalence, and we examine which causes are frequently associated with obesity. We use cause-of-<span class="hlt">death</span> data for all <span class="hlt">deaths</span> at ages 50-89 in 2010-2011. Since obesity may not be the underlying cause (UC) of <span class="hlt">death</span>, we compute age- and sex-standardized <span class="hlt">death</span> rates considering all mentions of obesity (multiple causes or MC). We use cluster analyses to identify patterns of cause-of-<span class="hlt">death</span> combinations. Obesity is selected as UC in no more than 20% of the <span class="hlt">deaths</span> with a mention of obesity. Mortality levels, whether measured from the UC or the MC, are weakly related to levels of prevalence. Patterns of cause-of-<span class="hlt">death</span> combinations are similar across the countries. In addition to strong <span class="hlt">links</span> with cardiovascular diseases and diabetes, we identify several less familiar associations. Considering all mentions on the <span class="hlt">deaths</span> certificates reduces the underestimation of obesity-related mortality based on the UC only. It also enables us to describe the various mortality patterns involving obesity.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/8302987','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/8302987"><span>Management of <span class="hlt">death</span> and grief in obituary and in memoriam pages of Nigerian newspapers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Alali, A O</p> <p>1993-12-01</p> <p>This analysis of obituaries and in memoriam advertisements in Nigerian newspapers provides the identification of dimensions of content used to manage <span class="hlt">death</span> and grief. Ten dimensions of content were abstracted: pictorial representation is a widespread practice, immediacy of announcement following <span class="hlt">death</span> is an appropriate etiquette in the management of <span class="hlt">death</span>, funeral arrangements are included as open invitation to a community of mourners, advertisements indicate direct contact and communication with the deceased, contents suggest the belief in personal immortality of the soul, religion is a pervasive and dominating force in advertisements, there are similarities in choice of words used in <span class="hlt">death</span> advertisements, there is recognition of the temporal nature of life, mourning seems to be an ongoing process, and often the deceased is perceived as resting in peace. Never do obituaries and in memoriam statements include the flaws of the deceased. Clearly, the dimensions of content in the obituaries and in memoriam advertisements of Nigerian newspapers are a specific cultural behavior of people who exhibit similarity in the management of <span class="hlt">death</span> and grief. These advertisements serve as an unbroken <span class="hlt">link</span> between the deceased and the bereaved. This study also suggests that openness to <span class="hlt">death</span> is the appropriate etiquette in the management of <span class="hlt">death</span> and grief in Nigeria.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24754554','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24754554"><span>Leading causes of <span class="hlt">death</span> and all-cause mortality in American Indians and Alaska Natives.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Espey, David K; Jim, Melissa A; Cobb, Nathaniel; Bartholomew, Michael; Becker, Tom; Haverkamp, Don; Plescia, Marcus</p> <p>2014-06-01</p> <p>We present regional patterns and trends in all-cause mortality and leading causes of <span class="hlt">death</span> in American Indians and Alaska Natives (AI/ANs). US National <span class="hlt">Death</span> Index records were <span class="hlt">linked</span> with Indian Health Service (IHS) registration records to identify AI/AN <span class="hlt">deaths</span> misclassified as non-AI/AN. We analyzed temporal trends for 1990 to 2009 and comparisons between non-Hispanic AI/AN and non-Hispanic White persons by geographic region for 1999 to 2009. Results focus on IHS Contract Health Service Delivery Area counties in which less race misclassification occurs. From 1990 to 2009 AI/AN persons did not experience the significant decreases in all-cause mortality seen for Whites. For 1999 to 2009 the all-cause <span class="hlt">death</span> rate in CHSDA counties for AI/AN persons was 46% more than that for Whites. <span class="hlt">Death</span> rates for AI/AN persons varied as much as 50% among regions. Except for heart disease and cancer, subsequent ranking of specific causes of <span class="hlt">death</span> differed considerably between AI/AN and White persons. AI/AN populations continue to experience much higher <span class="hlt">death</span> rates than Whites. Patterns of mortality are strongly influenced by the high incidence of diabetes, smoking prevalence, problem drinking, and social determinants. Much of the observed excess mortality can be addressed through known public health interventions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28728061','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28728061"><span>Qualifying information on <span class="hlt">deaths</span> and serious injuries caused by road traffic in five Brazilian capitals using record linkage.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mandacaru, Polyana Maria Pimenta; Andrade, Ana Lucia; Rocha, Marli Souza; Aguiar, Fernanda Pinheiro; Nogueira, Maria Sueli M; Girodo, Anne Marielle; Pedrosa, Ana Amélia Galas; Oliveira, Vera Lídia Alves de; Alves, Marta Maria Malheiros; Paixão, Lúcia Maria Miana M; Malta, Deborah Carvalho; Silva, Marta Maria Alves; Morais Neto, Otaliba Libanio de</p> <p>2017-09-01</p> <p>Road traffic crashes (RTC) are an important public health problem, accounting for 1.2 million <span class="hlt">deaths</span> per year worldwide. In Brazil, approximately 40,000 <span class="hlt">deaths</span> caused by RTC occur every year, with different trends in the Federal Units. However, these figures may be even greater if health databases are <span class="hlt">linked</span> to police records. In addition, the linkage procedure would make it possible to qualify information from the health and police databases, improving the quality of the data regarding underlying cause of <span class="hlt">death</span>, cause of injury in hospital records, and injury severity. This study <span class="hlt">linked</span> different data sources to measure the numbers of <span class="hlt">deaths</span> and serious injuries and to estimate the percentage of corrections regarding the underlying cause of <span class="hlt">death</span>, cause of injury, and the severity injury in victims in matched pairs from record linkage in five representative state capitals of the five macro-regions of Brazil. This cross-sectional, population-based study used data from the Hospital Information System (HIS), Mortality Information System (MIS), and Police Road Traffic database of Belo Horizonte, Campo Grande, Curitiba, Palmas, and Teresina, for the year 2013 for Teresina, and 2012 for the other capitals. Rec<span class="hlt">Link</span> III was used to perform probabilistic record linkage by identifying matched pairs to calculate the global correction percentage of the underlying cause of <span class="hlt">death</span>, the circumstance that caused the road traffic injury, and the injury severity of the victims in the police database. There was a change in the cause of injury in the HIS, with an overall percentage of correction estimated at 24.4% for Belo Horizonte, 96.9% for Campo Grande, 100.0% for Palmas, and 33.2% for Teresina. The overall percentages of correction of the underlying cause of <span class="hlt">death</span> in the MIS were 29.9%, 11.9%, 4.2%, and 33.5% for Belo Horizonte, Campo Grande, Curitiba, and Teresina, respectively. The correction of the classification of injury severity in police database were 100.0% for Belo</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol2/pdf/CFR-2011-title20-vol2-sec410-214.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol2/pdf/CFR-2011-title20-vol2-sec410-214.pdf"><span>20 CFR 410.214 - Conditions of entitlement; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Requirements for Entitlement... years after the miner's <span class="hlt">death</span>, whichever is later, or it is shown to the satisfaction of the... chapter), at the time of the miner's <span class="hlt">death</span>. (c) In addition to the requirements set forth in paragraphs (a...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24815896','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24815896"><span>Fear and loathing in Mississippi: the attack on cAMP <span class="hlt">sister</span> spirit.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Greene, Kate</p> <p>2003-01-01</p> <p>SUMMARY In 1993, the small rural community of Ovett, Miss., and a group of self-described radical lesbian feminists clashed over the establishment by the women of a feminist educational retreat known as Camp <span class="hlt">Sister</span> Spirit. This dispute took the form of physical and psychological harassment of the women, wide-open public debate in the community, in the press, and on television, federal mediation efforts, and two lawsuits. This article analyzes this dispute using Mary Daly's seven patterns of the sado-ritual syndrome (Daly, 1978). The analysis examines the ideological and moral standpoints of the participants, the issues of "blaming the victim" and scapegoating, the development of the conflict from a dispute between neighbors to the involvement of international media, national activists and the Clinton Administration, the transformation of the conflict from a political to legal dispute, the representations of the groups within the community and the media, the effect of public opinion on the dispute, and the politics of the media in the dispute.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4980104','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4980104"><span>Genomic analysis reveals hidden biodiversity within colugos, the <span class="hlt">sister</span> group to primates</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mason, Victor C.; Li, Gang; Minx, Patrick; Schmitz, Jürgen; Churakov, Gennady; Doronina, Liliya; Melin, Amanda D.; Dominy, Nathaniel J.; Lim, Norman T-L.; Springer, Mark S.; Wilson, Richard K.; Warren, Wesley C.; Helgen, Kristofer M.; Murphy, William J.</p> <p>2016-01-01</p> <p>Colugos are among the most poorly studied mammals despite their centrality to resolving supraordinal primate relationships. Two described species of these gliding mammals are the sole living members of the order Dermoptera, distributed throughout Southeast Asia. We generated a draft genome sequence for a Sunda colugo and a Philippine colugo reference alignment, and used these to identify colugo-specific genetic changes that were enriched in sensory and musculoskeletal-related genes that likely underlie their nocturnal and gliding adaptations. Phylogenomic analysis and catalogs of rare genomic changes overwhelmingly support the contested hypothesis that colugos are the <span class="hlt">sister</span> group to primates (Primatomorpha), to the exclusion of treeshrews. We captured ~140 kb of orthologous sequence data from colugo museum specimens sampled across their range and identified large genetic differences between many geographically isolated populations that may result in a >300% increase in the number of recognized colugo species. Our results identify conservation units to mitigate future losses of this enigmatic mammalian order. PMID:27532052</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2424099','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2424099"><span>Institutionalization of Older Adults After the <span class="hlt">Death</span> of a Spouse</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nihtilä, Elina; Martikainen, Pekka</p> <p>2008-01-01</p> <p>Objectives. We investigated the risk of entering long-term institutional care after the <span class="hlt">death</span> of a spouse in relation to the duration of widowhood among older Finnish men and women. We also examined whether high levels of education or household income buffered the effects of bereavement on institutionalization. Methods. We used <span class="hlt">linked</span> register-based data on Finnish adults 65 years or older who were living with a spouse at the beginning of the study period (n=140902) and were followed from January 1998 to December 2002. Results. The excess risk of institutionalization was highest during the first month following a spouse’s <span class="hlt">death</span> compared with still living with a spouse (adjusted hazard ratio=3.31 for men, 3.62 for women). This risk decreased over time among both men and women. The relative effect of the duration of widowhood on institutionalization did not significantly vary according to the level of education or income. Conclusions. Risk of institutionalization is particularly high immediately after the <span class="hlt">death</span> of a spouse, demonstrating the importance of loss of social and instrumental support. PMID:18511726</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26190106','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26190106"><span>A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell <span class="hlt">Death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ma, Hongming; Dang, Ying; Wu, Yonggan; Jia, Gengxiang; Anaya, Edgar; Zhang, Junli; Abraham, Sojan; Choi, Jang-Gi; Shi, Guojun; Qi, Ling; Manjunath, N; Wu, Haoquan</p> <p>2015-07-28</p> <p>West Nile virus (WNV) causes an acute neurological infection attended by massive neuronal cell <span class="hlt">death</span>. However, the mechanism(s) behind the virus-induced cell <span class="hlt">death</span> is poorly understood. Using a library containing 77,406 sgRNAs targeting 20,121 genes, we performed a genome-wide screen followed by a second screen with a sub-library. Among the genes identified, seven genes, EMC2, EMC3, SEL1L, DERL2, UBE2G2, UBE2J1, and HRD1, stood out as having the strongest phenotype, whose knockout conferred strong protection against WNV-induced cell <span class="hlt">death</span> with two different WNV strains and in three cell lines. Interestingly, knockout of these genes did not block WNV replication. Thus, these appear to be essential genes that <span class="hlt">link</span> WNV replication to downstream cell <span class="hlt">death</span> pathway(s). In addition, the fact that all of these genes belong to the ER-associated protein degradation (ERAD) pathway suggests that this might be the primary driver of WNV-induced cell <span class="hlt">death</span>. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=death&id=EJ997412','ERIC'); return false;" href="https://eric.ed.gov/?q=death&id=EJ997412"><span>Exploring Children's Understanding of <span class="hlt">Death</span>: Through Drawings and the <span class="hlt">Death</span> Concept Questionnaire</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bonoti, Fotini; Leondari, Angeliki; Mastora, Adelais</p> <p>2013-01-01</p> <p>To investigate whether children's understanding of the concept of <span class="hlt">death</span> varies as a function of <span class="hlt">death</span> experience and age, 52 children aged 7, 9, and 11 years (26 had a personal <span class="hlt">death</span> experience), drew a picture reflecting the meaning of the word <span class="hlt">death</span> and completed the <span class="hlt">Death</span> Concept Questionnaire for examination of Human and Animal <span class="hlt">Death</span>. The…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27659583','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27659583"><span>Good <span class="hlt">Deaths</span>, "Stupid <span class="hlt">Deaths</span>": Humane Medicine and the Call of Invisible Bodies.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ryan, Maura A</p> <p>2016-12-01</p> <p>Jeffrey Bishop's The Anticipatory Corpse exposes a functional metaphysics at the root of contemporary medical practice that gives rise to inhumane medicine, especially at the end of life. His critique of medicine argues for alternative spaces and practices in which the communal significance of the body, its telos, can be restored and the meaning of a "good <span class="hlt">death</span>" enriched. This essay develops an alternative epistemology of the body, drawing from Christian theological accounts of the communal or Eucharistic body and <span class="hlt">linking</span> liturgical practices to the cultivation of solidarity. It argues for an epistemology of the body that makes visible the invisible bodies at medicine's margins and illumines the disparate worlds of health care globally. © The Author 2016. Published by Oxford University Press, on behalf of the Journal of Medicine and Philosophy Inc. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ1134702.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ1134702.pdf"><span>Answering My <span class="hlt">Sister</span>'s Question: The Critical Importance of Education for Diversity in Those Spaces Where We Think We Are All the Same</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Corbett, Michael</p> <p>2010-01-01</p> <p>This essay is a response to a question about school desegregation in Nova Scotia, Canada posed by my <span class="hlt">sister</span> in 2008. I argue that the question itself illustrates the extent to which critical analysis of the politics of race in Canadian schools, particularly in rural areas, is seldom taken up. This feeds into a persistent mythology of a racially…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4934391','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4934391"><span>Differences in mycorrhizal communities between Epipactis palustris, E. helleborine and its presumed <span class="hlt">sister</span> species E. neerlandica</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Jacquemyn, Hans; Waud, Michael; Lievens, Bart; Brys, Rein</p> <p>2016-01-01</p> <p>Background and Aims In orchid species that have populations occurring in strongly contrasting habitats, mycorrhizal divergence and other habitat-specific adaptations may lead to the formation of reproductively isolated taxa and ultimately to species formation. However, little is known about the mycorrhizal communities associated with recently diverged <span class="hlt">sister</span> taxa that occupy different habitats. Methods In this study, 454 amplicon pyrosequencing was used to investigate mycorrhizal communities associating with Epipactis helleborine in its typical forest habitat and with its presumed <span class="hlt">sister</span> species E. neerlandica that almost exclusively occurs in coastal dune habitats. Samples of the phylogenetically more distant E. palustris, which co-occurred with E. neerlandica, were also included to investigate the role of habitat-specific conditions on mycorrhizal communities. Results A total of 105 operational taxonomic units (OTUs) of putative orchid mycorrhizal fungi were observed in the three studied species. The majority of these fungi were endophytic fungi of Helotiales and ectomycorrhizal fungi belonging to Thelephoraceae, Sebacinaceae and Inocybaceae. In addition, a large number of other ectomycorrhizal taxa were detected, including Cortinarius, Cenococcum, Tuber, Geopora, Wilcoxina, Meliniomyces, Hebeloma, Tricholoma, Russula and Peziza. Mycorrhizal communities differed significantly between the three species, but differences were most pronounced between the forest species (E. helleborine) and the two dune slack species (E. neerlandica and E. palustris). Conclusion The results clearly showed that recently diverged orchid species that occupy different habitats were characterized by significantly different mycorrhizal communities and call for more detailed experiments that aim at elucidating the contribution of habitat-specific adaptations in general and mycorrhizal divergence in particular to the process of speciation in orchids. PMID:26946528</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3010607','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3010607"><span><span class="hlt">DEATH</span>, DYING AND NEAR <span class="hlt">DEATH</span> EXPERIENCE</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Singh, Ajai R.; Bagadia, V.N.; Pradhan, P.V.; Acharya, V.N.</p> <p>1988-01-01</p> <p>SUMMARY Psychology of <span class="hlt">deaths</span> due to acute medical emergencies is under-researched. Most studies till now have concentrated on extended-<span class="hlt">death</span> situations like malignancy. This open pilot study of twenty five patients examines the psychological state of patients during a life threatening acute medical illness (Group A, ten patients) and of those who survive such an experience (Group B, fifteen patients). The study finds psychological exploration both possible and necessary if carried out in a discreet manner. Salient features of the interview technique are discussed. The study finds out whether patients are aware of the possibility of terminality. The psychological disturbances manifest and nature of care expected are also discussed. Near <span class="hlt">Death</span> Experiences of those who acknowledge their occurence are reported. Some nuances of thanatological research are high-lighted: What are the abilities needed in an interviewer? Can such exploration increase psychological distress in a patient already prone to it because of serious medical sickness? What impact such research can have on the interviewer himself? The paper answers some of these common questions while developing the method of thanatological study in acute medical <span class="hlt">death</span>-situations. PMID:21927325</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24316735','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24316735"><span>Orphan nuclear receptor TR3 acts in autophagic cell <span class="hlt">death</span> via mitochondrial signaling pathway.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wang, Wei-jia; Wang, Yuan; Chen, Hang-zi; Xing, Yong-zhen; Li, Feng-wei; Zhang, Qian; Zhou, Bo; Zhang, Hong-kui; Zhang, Jie; Bian, Xue-li; Li, Li; Liu, Yuan; Zhao, Bi-xing; Chen, Yan; Wu, Rong; Li, An-zhong; Yao, Lu-ming; Chen, Ping; Zhang, Yi; Tian, Xu-yang; Beermann, Friedrich; Wu, Mian; Han, Jiahuai; Huang, Pei-qiang; Lin, Tianwei; Wu, Qiao</p> <p>2014-02-01</p> <p>Autophagy is <span class="hlt">linked</span> to cell <span class="hlt">death</span>, yet the associated mechanisms are largely undercharacterized. We discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell <span class="hlt">death</span> with the participation of orphan nuclear receptor TR3. A sequence of molecular events leading to cellular demise is launched by a specific chemical compound, 1-(3,4,5-trihydroxyphenyl)nonan-1-one, newly acquired from screening a library of TR3-targeting compounds. The autophagic cascade comprises TR3 translocation to mitochondria through interaction with the mitochondrial outer membrane protein Nix, crossing into the mitochondrial inner membrane through Tom40 and Tom70 channel proteins, dissipation of mitochondrial membrane potential by the permeability transition pore complex ANT1-VDAC1 and induction of autophagy. This process leads to excessive mitochondria clearance and irreversible cell <span class="hlt">death</span>. It implicates a new approach to melanoma therapy through activation of a mitochondrial signaling pathway that integrates a nuclear receptor with autophagy for cell <span class="hlt">death</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=better+AND+angels+AND+nature&id=ED246995','ERIC'); return false;" href="https://eric.ed.gov/?q=better+AND+angels+AND+nature&id=ED246995"><span>Children and <span class="hlt">Death</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Brennan, Andrew J. J.</p> <p></p> <p>Health professionals and educators should develop their abilities to educate about <span class="hlt">death</span> and to comfort the bereaved. Due to lower <span class="hlt">death</span> rates, the lack of philosophical religious views, and distorted perceptions of <span class="hlt">death</span> contributed by television, <span class="hlt">death</span> has become a mystery instead of a segment of the common experience. Particularly when a child…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26114245','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26114245"><span>The Role of <span class="hlt">Sister</span> Cities' Staff Exchanges in Developing "Learning Cities": Exploring Necessary and Sufficient Conditions in Social Capital Development Utilizing Proportional Odds Modeling.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Buckley, Patrick Henry; Takahashi, Akio; Anderson, Amy</p> <p>2015-06-24</p> <p>In the last half century former international adversaries have become cooperators through networking and knowledge sharing for decision making aimed at improving quality of life and sustainability; nowhere has this been more striking then at the urban level where such activity is seen as a key component in building "learning cities" through the development of social capital. Although mega-cities have been leaders in such efforts, mid-sized cities with lesser resource endowments have striven to follow by focusing on more frugal <span class="hlt">sister</span> city type exchanges. The underlying thesis of our research is that great value can be derived from city-to-city exchanges through social capital development. However, such a study must differentiate between necessary and sufficient conditions. Past studies assumed necessary conditions were met and immediately jumped to demonstrating the existence of structural relationships by measuring networking while further assuming that the existence of such demonstrated a parallel development of cognitive social capital. Our research addresses this lacuna by stepping back and critically examining these assumptions. To accomplish this goal we use a Proportional Odds Modeling with a Cumulative Logit <span class="hlt">Link</span> approach to demonstrate the existence of a common latent structure, hence asserting that necessary conditions are met.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=death&pg=2&id=EJ955767','ERIC'); return false;" href="https://eric.ed.gov/?q=death&pg=2&id=EJ955767"><span>Religiosity and the Construction of <span class="hlt">Death</span> in Turkish <span class="hlt">Death</span> Announcements, 1970-2009</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Ergin, Murat</p> <p>2012-01-01</p> <p><span class="hlt">Death</span> and rituals performed after <span class="hlt">death</span> reflect and reproduce social distinctions despite <span class="hlt">death</span>'s popular reputation as a great leveler. This study examines expressions of religiosity and constructions of <span class="hlt">death</span> in Turkish <span class="hlt">death</span> announcements, paying particular attention to gendered, ethnic, and temporal variations as well as markers of status and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25960492','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25960492"><span>PA6 <span class="hlt">Death</span> chat: engaging with dying and <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Goodhead, Andrew; Hartley, Nigel</p> <p>2015-04-01</p> <p>Talking about <span class="hlt">death</span> continues to be a social taboo. St Christopher's has a large, welcoming social space, (The Anniversary Centre) and is committed to opening up its buildings in a number of ways. The St Christopher's social programme, of which <span class="hlt">Death</span> Chat is part, aims to break down social taboos. Hospices have a responsibility to engage creatively with patients, family members, carers and the wider community. <span class="hlt">Death</span> Chat, held in the hospice buildings, enables honest discussion about dying and <span class="hlt">death</span> and topics surrounding these themes. <span class="hlt">Death</span> Chat meets weekly and is an open meeting that takes a different subject each week as the starting point for conversation. Cheese and wine are shared and participants quickly find a place in the group. <span class="hlt">Death</span> Chat has attracted patients, family members, bereaved relatives and the community since September 2013. Attendees have reflected that coming has broken taboos. Peter said, 'it's nowhere near as depressing as it sounds; it's a nice, friendly atmosphere - a convivial place.' Molly found <span class="hlt">Death</span> Chat to be a welcoming, open and challenging space, 'I have learnt that <span class="hlt">death</span> is more about my attitude to life than anything else. It has been by far the most important lesson I have learnt since dealing with bereavement.' <span class="hlt">Death</span> Chat provides a forum in which discussion of dying and <span class="hlt">death</span> for recognises that these are social events and reclaims them from being taboo, to being a normal part of life's experience. © 2015, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1783675','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1783675"><span>Roles of the <span class="hlt">sister</span> chromatid cohesion apparatus in gene expression, development, and human syndromes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dorsett, Dale</p> <p>2006-01-01</p> <p>The <span class="hlt">sister</span> chromatid cohesion apparatus mediates physical pairing of duplicated chromosomes. This pairing is essential for appropriate distribution of chromosomes into the daughter cells upon cell division. Recent evidence shows that the cohesion apparatus, which is a significant structural component of chromosomes during interphase, also affects gene expression and development. The Cornelia de Lange (CdLS) and Roberts/SC phocomelia (RBS/SC) genetic syndromes in humans are caused by mutations affecting components of the cohesion apparatus. Studies in Drosophila suggest that effects on gene expression are most likely responsible for developmental alterations in CdLS. Effects on chromatid cohesion are apparent in RBS/SC syndrome, but data from yeast and Drosophila point to the likelihood that changes in expression of genes located in heterochromatin could contribute to the developmental deficits. PMID:16819604</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4985112','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4985112"><span>Causes and Disparities in <span class="hlt">Death</span> Rates Among Urban American Indian and Alaska Native Populations, 1999–2009</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Espey, David K.; Groom, Amy V.; Phillips, Leslie E.; Haverkamp, Donald S.; Stanley, Sandte L.</p> <p>2016-01-01</p> <p>Objectives. To characterize the leading causes of <span class="hlt">death</span> for the urban American Indian/Alaska Native (AI/AN) population and compare with urban White and rural AI/AN populations. Methods. We <span class="hlt">linked</span> Indian Health Service patient registration records with the National <span class="hlt">Death</span> Index to reduce racial misclassification in <span class="hlt">death</span> certificate data. We calculated age-adjusted urban AI/AN <span class="hlt">death</span> rates for the period 1999–2009 and compared those with corresponding urban White and rural AI/AN <span class="hlt">death</span> rates. Results. The top-5 leading causes of <span class="hlt">death</span> among urban AI/AN persons were heart disease, cancer, unintentional injury, diabetes, and chronic liver disease and cirrhosis. Compared with urban White persons, urban AI/AN persons experienced significantly higher <span class="hlt">death</span> rates for all top-5 leading causes. The largest disparities were for diabetes and chronic liver disease and cirrhosis. In general, urban and rural AI/AN persons had the same leading causes of <span class="hlt">death</span>, although urban AI/AN persons had lower <span class="hlt">death</span> rates for most conditions. Conclusions. Urban AI/AN persons experience significant disparities in <span class="hlt">death</span> rates compared with their White counterparts. Public health and clinical interventions should target urban AI/AN persons to address behaviors and conditions contributing to health disparities. PMID:26890168</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27068745','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27068745"><span>An Alzheimer Disease-<span class="hlt">linked</span> Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hashimoto, Yuichi; Toyama, Yuka; Kusakari, Shinya; Nawa, Mikiro; Matsuoka, Masaaki</p> <p>2016-06-03</p> <p>A missense mutation (T835M) in the uncoordinated-5C (UNC5C) netrin receptor gene increases the risk of late-onset Alzheimer disease (AD) and also the vulnerability of neurons harboring the mutation to various insults. The molecular mechanisms underlying T835M-UNC5C-induced <span class="hlt">death</span> remain to be elucidated. In this study, we show that overexpression of wild-type UNC5C causes low-grade <span class="hlt">death</span>, which is intensified by an AD-<span class="hlt">linked</span> mutation T835M. An AD-<span class="hlt">linked</span> survival factor, calmodulin-like skin protein (CLSP), and a natural ligand of UNC5C, netrin1, inhibit this <span class="hlt">death</span>. T835M-UNC5C-induced neuronal cell <span class="hlt">death</span> is mediated by an intracellular <span class="hlt">death</span>-signaling cascade, consisting of <span class="hlt">death</span>-associated protein kinase 1/protein kinase D/apoptosis signal-regulating kinase 1 (ASK1)/JNK/NADPH oxidase/caspases, which merges at ASK1 with a <span class="hlt">death</span>-signaling cascade, mediated by amyloid β precursor protein (APP). Notably, netrin1 also binds to APP and partially inhibits the <span class="hlt">death</span>-signaling cascade, induced by APP. These results may provide new insight into the amyloid β-independent pathomechanism of AD. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29776336','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29776336"><span>Phylogenomic analysis of Apoidea sheds new light on the <span class="hlt">sister</span> group of bees.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sann, Manuela; Niehuis, Oliver; Peters, Ralph S; Mayer, Christoph; Kozlov, Alexey; Podsiadlowski, Lars; Bank, Sarah; Meusemann, Karen; Misof, Bernhard; Bleidorn, Christoph; Ohl, Michael</p> <p>2018-05-18</p> <p>Apoid wasps and bees (Apoidea) are an ecologically and morphologically diverse group of Hymenoptera, with some species of bees having evolved eusocial societies. Major problems for our understanding of the evolutionary history of Apoidea have been the difficulty to trace the phylogenetic origin and to reliably estimate the geological age of bees. To address these issues, we compiled a comprehensive phylogenomic dataset by simultaneously analyzing target DNA enrichment and transcriptomic sequence data, comprising 195 single-copy protein-coding genes and covering all major lineages of apoid wasps and bee families. Our compiled data matrix comprised 284,607 nucleotide sites that we phylogenetically analyzed by applying a combination of domain- and codon-based partitioning schemes. The inferred results confirm the polyphyletic status of the former family "Crabronidae", which comprises nine major monophyletic lineages. We found the former subfamily Pemphredoninae to be polyphyletic, comprising three distantly related clades. One of them, Ammoplanina, constituted the <span class="hlt">sister</span> group of bees in all our analyses. We estimate the origin of bees to be in the Early Cretaceous (ca. 128 million years ago), a time period during which angiosperms rapidly radiated. Finally, our phylogenetic analyses revealed that within the Apoidea, (eu)social societies evolved exclusively in a single clade that comprises pemphredonine and philanthine wasps as well as bees. By combining transcriptomic sequences with those obtained via target DNA enrichment, we were able to include an unprecedented large number of apoid wasps in a phylogenetic study for tracing the phylogenetic origin of bees. Our results confirm the polyphyletic nature of the former wasp family Crabonidae, which we here suggest splitting into eight families. Of these, the family Ammoplanidae possibly represents the extant <span class="hlt">sister</span> lineage of bees. Species of Ammoplanidae are known to hunt thrips, of which some aggregate on flowers and</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2649772','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2649772"><span>Ancient fossil specimens of extinct species are genetically more distant to an outgroup than extant <span class="hlt">sister</span> species are</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Huang, Shi</p> <p>2009-01-01</p> <p>There exists a remarkable correlation between genetic distance as measured by protein or DNA dissimilarity and time of species divergence as inferred from fossil records. This observation has provoked the molecular clock hypothesis. However, data inconsistent with the hypothesis have steadily accumulated in recent years from studies of extant organisms. Here the published DNA and protein sequences from ancient fossil specimens were examined to see if they would support the molecular clock hypothesis. The hypothesis predicts that ancient specimens cannot be genetically more distant to an outgroup than extant <span class="hlt">sister</span> species are. Also, two distinct ancient specimens cannot be genetically more distant than their extant <span class="hlt">sister</span> species are. The findings here do not conform to these predictions. Neanderthals are more distant to chimpanzees and gorillas than modern humans are. Dinosaurs are more distant to frogs than extant birds are. Mastodons are more distant to opossums than other placental mammals are. The genetic distance between dinosaurs and mastodons is greater than that between extant birds and mammals. Therefore, while the molecular clock hypothesis is consistent with some data from extant organisms, it has yet to find support from ancient fossils. Far more damaging to the hypothesis than data from extant organisms, which merely question the constancy of mutation rate, the study of ancient fossil organisms here challenges for the first time the fundamental premise of modern evolution theory that genetic distances had always increased with time in the past history of life on Earth. PMID:18600632</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3569643','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3569643"><span>The impairment of HCCS leads to MLS syndrome by activating a non-canonical cell <span class="hlt">death</span> pathway in the brain and eyes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Indrieri, Alessia; Conte, Ivan; Chesi, Giancarlo; Romano, Alessia; Quartararo, Jade; Tatè, Rosarita; Ghezzi, Daniele; Zeviani, Massimo; Goffrini, Paola; Ferrero, Ileana; Bovolenta, Paola; Franco, Brunella</p> <p>2013-01-01</p> <p>Mitochondrial-dependent (intrinsic) programmed cell <span class="hlt">death</span> (PCD) is an essential homoeostatic mechanism that selects bioenergetically proficient cells suitable for tissue/organ development. However, the <span class="hlt">link</span> between mitochondrial dysfunction, intrinsic apoptosis and developmental anomalies has not been demonstrated to date. Now we provide the evidence that non-canonical mitochondrial-dependent apoptosis explains the phenotype of microphthalmia with linear skin lesions (MLS), an X-<span class="hlt">linked</span> developmental disorder caused by mutations in the holo-cytochrome c-type synthase (HCCS) gene. By taking advantage of a medaka model that recapitulates the MLS phenotype we demonstrate that downregulation of hccs, an essential player of the mitochondrial respiratory chain (MRC), causes increased cell <span class="hlt">death</span> via an apoptosome-independent caspase-9 activation in brain and eyes. We also show that the unconventional activation of caspase-9 occurs in the mitochondria and is triggered by MRC impairment and overproduction of reactive oxygen species (ROS). We thus propose that HCCS plays a key role in central nervous system (CNS) development by modulating a novel non-canonical start-up of cell <span class="hlt">death</span> and provide the first experimental evidence for a mechanistic <span class="hlt">link</span> between mitochondrial dysfunction, intrinsic apoptosis and developmental disorders. PMID:23239471</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3595029','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3595029"><span>Chloroplast Phylogenomics Indicates that Ginkgo biloba Is <span class="hlt">Sister</span> to Cycads</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wu, Chung-Shien; Chaw, Shu-Miaw; Huang, Ya-Yi</p> <p>2013-01-01</p> <p>Molecular phylogenetic studies have not yet reached a consensus on the placement of Ginkgoales, which is represented by the only living species, Ginkgo biloba (common name: ginkgo). At least six discrepant placements of ginkgo have been proposed. This study aimed to use the chloroplast phylogenomic approach to examine possible factors that lead to such disagreeing placements. We found the sequence types used in the analyses as the most critical factor in the conflicting placements of ginkgo. In addition, the placement of ginkgo varied in the trees inferred from nucleotide (NU) sequences, which notably depended on breadth of taxon sampling, tree-building methods, codon positions, positions of Gnetopsida (common name: gnetophytes), and including or excluding gnetophytes in data sets. In contrast, the trees inferred from amino acid (AA) sequences congruently supported the monophyly of a ginkgo and Cycadales (common name: cycads) clade, regardless of which factors were examined. Our site-stripping analysis further revealed that the high substitution saturation of NU sequences mainly derived from the third codon positions and contributed to the variable placements of ginkgo. In summary, the factors we surveyed did not affect results inferred from analyses of AA sequences. Congruent topologies in our AA trees give more confidence in supporting the ginkgo–cycad <span class="hlt">sister</span>-group hypothesis. PMID:23315384</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27713409','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27713409"><span>Evolutionary interplay between <span class="hlt">sister</span> cytochrome P450 genes shapes plasticity in plant metabolism.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Liu, Zhenhua; Tavares, Raquel; Forsythe, Evan S; André, François; Lugan, Raphaël; Jonasson, Gabriella; Boutet-Mercey, Stéphanie; Tohge, Takayuki; Beilstein, Mark A; Werck-Reichhart, Danièle; Renault, Hugues</p> <p>2016-10-07</p> <p>Expansion of the cytochrome P450 gene family is often proposed to have a critical role in the evolution of metabolic complexity, in particular in microorganisms, insects and plants. However, the molecular mechanisms underlying the evolution of this complexity are poorly understood. Here we describe the evolutionary history of a plant P450 retrogene, which emerged and underwent fixation in the common ancestor of Brassicales, before undergoing tandem duplication in the ancestor of Brassicaceae. Duplication leads first to gain of dual functions in one of the copies. Both <span class="hlt">sister</span> genes are retained through subsequent speciation but eventually return to a single copy in two of three diverging lineages. In the lineage in which both copies are maintained, the ancestral functions are split between paralogs and a novel function arises in the copy under relaxed selection. Our work illustrates how retrotransposition and gene duplication can favour the emergence of novel metabolic functions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27777376','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27777376"><span>Issues using linkage of hospital records and <span class="hlt">death</span> certificate data to determine the size of a potential palliative care population.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Brameld, Kate; Spilsbury, Katrina; Rosenwax, Lorna; Murray, Kevin; Semmens, James</p> <p>2017-06-01</p> <p>Studies aiming to identify palliative care populations have used data from <span class="hlt">death</span> certificates and in some cases hospital records. The size and characteristics of the identified populations can show considerable variation depending on the data sources used. It is important that service planners and researchers are aware of this. To illustrate the differences in the size and characteristics of a potential palliative care population depending on the differential use of <span class="hlt">linked</span> hospital records and <span class="hlt">death</span> certificate data. Retrospective cohort study. The cohort consisted of 23,852 people aged 20 years and over who died in Western Australia between 1 January 2009 and 31 December 2010 after excluding <span class="hlt">deaths</span> related to pregnancy or trauma. Within this cohort, the number, proportion and characteristics of people who died from one or more of 10 medical conditions considered amenable to palliative care were identified using <span class="hlt">linked</span> hospital records and <span class="hlt">death</span> certificate data. Depending on the information source(s) used, between 43% and 73% of the 23,852 people who died had a condition potentially amenable to palliative care identified. The median age at <span class="hlt">death</span> and the sex distribution of the decedents by condition also varied with the information source. Health service planners and researchers need to be aware of the limitations when using hospital records and <span class="hlt">death</span> certificate data to determine a potential palliative care population. The use of Emergency Department and other administrative data sources could further exacerbate this variation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25146045','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25146045"><span>The serine protease inhibitor TLCK attenuates intrinsic <span class="hlt">death</span> pathways in neurons upstream of mitochondrial demise.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Reuther, C; Ganjam, G K; Dolga, A M; Culmsee, C</p> <p>2014-11-01</p> <p>It is well-established that activation of proteases, such as caspases, calpains and cathepsins are essential components in signaling pathways of programmed cell <span class="hlt">death</span> (PCD). Although these proteases have also been <span class="hlt">linked</span> to mechanisms of neuronal cell <span class="hlt">death</span>, they are dispensable in paradigms of intrinsic <span class="hlt">death</span> pathways, e.g. induced by oxidative stress. However, emerging evidence implicated a particular role for serine proteases in mechanisms of PCD in neurons. Here, we investigated the role of trypsin-like serine proteases in a model of glutamate toxicity in HT-22 cells. In these cells glutamate induces oxytosis, a form of caspase-independent cell <span class="hlt">death</span> that involves activation of the pro-apoptotic protein BH3 interacting-domain <span class="hlt">death</span> agonist (Bid), leading to mitochondrial demise and ensuing cell <span class="hlt">death</span>. In this model system, the trypsin-like serine protease inhibitor Nα-tosyl-l-lysine chloromethyl ketone hydrochloride (TLCK) inhibited mitochondrial damage and cell <span class="hlt">death</span>. Mitochondrial morphology alterations, the impairment of the mitochondrial membrane potential and ATP depletion were prevented and, moreover, lipid peroxidation induced by glutamate was completely abolished. Strikingly, truncated Bid-induced cell <span class="hlt">death</span> was not affected by TLCK, suggesting a detrimental activity of serine proteases upstream of Bid activation and mitochondrial demise. In summary, this study demonstrates the protective effect of serine protease inhibition by TLCK against oxytosis-induced mitochondrial damage and cell <span class="hlt">death</span>. These findings indicate that TLCK-sensitive serine proteases play a crucial role in cell <span class="hlt">death</span> mechanisms upstream of mitochondrial demise and thus, may serve as therapeutic targets in diseases, where oxidative stress and intrinsic pathways of PCD mediate neuronal cell <span class="hlt">death</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4035872','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4035872"><span>Leading Causes of <span class="hlt">Death</span> and All-Cause Mortality in American Indians and Alaska Natives</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Jim, Melissa A.; Cobb, Nathaniel; Bartholomew, Michael; Becker, Tom; Haverkamp, Don; Plescia, Marcus</p> <p>2014-01-01</p> <p>Objectives. We present regional patterns and trends in all-cause mortality and leading causes of <span class="hlt">death</span> in American Indians and Alaska Natives (AI/ANs). Methods. US National <span class="hlt">Death</span> Index records were <span class="hlt">linked</span> with Indian Health Service (IHS) registration records to identify AI/AN <span class="hlt">deaths</span> misclassified as non-AI/AN. We analyzed temporal trends for 1990 to 2009 and comparisons between non-Hispanic AI/AN and non-Hispanic White persons by geographic region for 1999 to 2009. Results focus on IHS Contract Health Service Delivery Area counties in which less race misclassification occurs. Results. From 1990 to 2009 AI/AN persons did not experience the significant decreases in all-cause mortality seen for Whites. For 1999 to 2009 the all-cause <span class="hlt">death</span> rate in CHSDA counties for AI/AN persons was 46% more than that for Whites. <span class="hlt">Death</span> rates for AI/AN persons varied as much as 50% among regions. Except for heart disease and cancer, subsequent ranking of specific causes of <span class="hlt">death</span> differed considerably between AI/AN and White persons. Conclusions. AI/AN populations continue to experience much higher <span class="hlt">death</span> rates than Whites. Patterns of mortality are strongly influenced by the high incidence of diabetes, smoking prevalence, problem drinking, and social determinants. Much of the observed excess mortality can be addressed through known public health interventions. PMID:24754554</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5947997','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5947997"><span>Obesity-related mortality in France, Italy, and the United States: a comparison using multiple cause-of-<span class="hlt">death</span> analysis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Barbieri, Magali; Egidi, Viviana; Demuru, Elena; Frova, Luisa; Meslé, France; Pappagallo, Marilena</p> <p>2018-01-01</p> <p>Objectives We investigate the reporting of obesity on <span class="hlt">death</span> certificates in three countries (France, Italy, and the United States) with different levels of prevalence, and we examine which causes are frequently associated with obesity. Methods We use cause-of-<span class="hlt">death</span> data for all <span class="hlt">deaths</span> at ages 50–89 in 2010–2011. Since obesity may not be the underlying cause (UC) of <span class="hlt">death</span>, we compute age- and sex- standardized <span class="hlt">death</span> rates considering all mentions of obesity (multiple causes or MC). We use cluster analyses to identify patterns of cause-of-<span class="hlt">death</span> combinations. Results Obesity is selected as UC in no more than 20% of the <span class="hlt">deaths</span> with a mention of obesity. Mortality levels, whether measured from the UC or the MC, are weakly related to levels of prevalence. Patterns of cause-of-<span class="hlt">death</span> combinations are similar across the countries. In addition to strong <span class="hlt">links</span> with cardiovascular diseases and diabetes, we identify several less familiar associations. Conclusions Considering all mentions on the <span class="hlt">deaths</span> certificates reduces the underestimation of obesity-related mortality based on the UC only. It also enables us to describe the various mortality patterns involving obesity. PMID:28497238</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27139707','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27139707"><span>From <span class="hlt">Death</span> to <span class="hlt">Death</span> Certificate: What do the Dead say?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gill, James R</p> <p>2017-03-01</p> <p>This is an overview of medicolegal <span class="hlt">death</span> investigation and <span class="hlt">death</span> certification. Postmortem toxicological analysis, particularly for ethanol and drugs of abuse, plays a large role in the forensic investigation of natural and unnatural <span class="hlt">deaths</span>. Postmortem drug concentrations must be interpreted in light of the autopsy findings and circumstances. Interpretations of drug and ethanol concentrations are important for <span class="hlt">death</span> certification, but they also may be important for other stakeholders such as police, attorneys, public health practitioners, and the next-of-kin.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22942468','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22942468"><span>Impact of fetal <span class="hlt">death</span> reporting requirements on early neonatal and fetal mortality rates and racial disparities.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tyler, Crystal P; Grady, Sue C; Grigorescu, Violanda; Luke, Barbara; Todem, David; Paneth, Nigel</p> <p>2012-01-01</p> <p>Racial disparities in infant and neonatal mortality vary substantially across the U.S. with some states experiencing wider disparities than others. Many factors are thought to contribute to these disparities, but state differences in fetal <span class="hlt">death</span> reporting have received little attention. We examined whether such reporting requirements may explain national variation in neonatal and fetal mortality rates and racial disparities. We used data on non-Hispanic white and non-Hispanic black infants from the U.S. 2000-2002 <span class="hlt">linked</span> birth/infant <span class="hlt">death</span> and fetal <span class="hlt">death</span> records to determine the degree to which state fetal <span class="hlt">death</span> reporting requirements explain national variation in neonatal and fetal mortality rates and racial disparities. States were grouped depending upon whether they based the lower limit for fetal <span class="hlt">death</span> reporting on birthweight alone, gestational age alone, both birthweight and gestational age, or required reporting of all fetal <span class="hlt">deaths</span>. Traditional methods and the fetuses-at-risk approach were used to calculate mortality rates, 95% confidence intervals, and relative and absolute racial disparity measures in these four groups. States with birthweight-alone fetal <span class="hlt">death</span> thresholds substantially underreported fetal <span class="hlt">deaths</span> at lower gestations and slightly overreported neonatal <span class="hlt">deaths</span> at older gestations. This finding was reflected by these states having the highest neonatal mortality rates and disparities, but the lowest fetal mortality rates and disparities. Using birthweight alone as a reporting threshold may promote some shift of fetal <span class="hlt">deaths</span> to newborn <span class="hlt">deaths</span>, contributing to racial disparities in neonatal mortality. The adoption of a uniform national threshold for reporting fetal <span class="hlt">deaths</span> could reduce systematic differences in live birth and fetal <span class="hlt">death</span> reporting.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27736202','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27736202"><span>Decreases in Suicide <span class="hlt">Deaths</span> and Attempts <span class="hlt">Linked</span> to the White Mountain Apache Suicide Surveillance and Prevention System, 2001-2012.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cwik, Mary F; Tingey, Lauren; Maschino, Alexandra; Goklish, Novalene; Larzelere-Hinton, Francene; Walkup, John; Barlow, Allison</p> <p>2016-12-01</p> <p>We evaluated the impact of a comprehensive, multitiered youth suicide prevention program among the White Mountain Apache of Arizona since its implementation in 2006. Using data from the tribally mandated Celebrating Life surveillance system, we compared the rates, numbers, and characteristics of suicide <span class="hlt">deaths</span> and attempts from 2007 to 2012 with those from 2001 to 2006. The overall Apache suicide <span class="hlt">death</span> rates dropped from 40.0 to 24.7 per 100 000 (38.3% decrease), and the rate among those aged 15 to 24 years dropped from 128.5 to 99.0 per 100 000 (23.0% decrease). The annual number of attempts also dropped from 75 (in 2007) to 35 individuals (in 2012). National rates remained relatively stable during this time, at 10 to 13 per 100 000. Although national rates remained stable or increased slightly, the overall Apache suicide <span class="hlt">death</span> rates dropped following the suicide prevention program. The community surveillance system served a critical role in providing a foundation for prevention programming and evaluation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23233086','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23233086"><span>SPG3A-<span class="hlt">linked</span> hereditary spastic paraplegia associated with cerebral glucose hypometabolism.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Terada, Tatsuhiro; Kono, Satoshi; Ouchi, Yasuomi; Yoshida, Kenichi; Hamaya, Yasushi; Kanaoka, Shigeru; Miyajima, Hiroaki</p> <p>2013-04-01</p> <p>SPG3A-<span class="hlt">linked</span> hereditary spastic paraplegia (HSP) is a rare autosomal dominant motor disorder caused by a mutation in the SPG3A gene, and is characterized by progressive motor weakness and spasticity in the lower limbs, without any other neurological abnormalities. SPG3A-<span class="hlt">linked</span> HSP caused by a R239C mutation has been reported to present a pure phenotype confined to impairment of the corticospinal tract. However, there is still a debate about the etiology of this motor deficit with regard to whether it is peripheral or central. We herein report two patients who were heterozygous for a R239C mutation in the SPG3A gene. Two middle-aged Japanese <span class="hlt">sisters</span> had been suffering from a pure phenotype of HSP since their childhood. Both patients had a significant decrease in glucose metabolism in the frontal cortex medially and dorsolaterally in a [(18)F]-fluorodeoxyglucose (FDG) positron emission photography (PET) study and low scores on the Frontal Assessment Battery. A real-time PCR analysis in normal subjects showed the frontal cortex to be the major location where SPG3A mRNA is expressed. The present finding that the frontal glucose hypometabolism was associated with frontal cognitive impairment indicates that widespread neuropathology associated with mutations in the SPG3A gene may be present more centrally than previously assumed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Death+AND+rates&pg=4&id=EJ233744','ERIC'); return false;" href="https://eric.ed.gov/?q=Death+AND+rates&pg=4&id=EJ233744"><span>Aging and <span class="hlt">Death</span> Education.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Pinder, Margaret M.; Hayslip, Bert, Jr.</p> <p>1980-01-01</p> <p>The elderly <span class="hlt">death</span> rate is somewhat higher than the <span class="hlt">death</span> rate in general. Numbers of schools with gerontological curricula and frequency of <span class="hlt">death</span> education courses are positively related to elderly <span class="hlt">death</span> rates. The contention that elderly <span class="hlt">deaths</span> have less social impact is not supported. (JAC)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5045961','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5045961"><span>How well can morphology assess cell <span class="hlt">death</span> modality? A proteomics study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Chernobrovkin, Alexey L; Zubarev, Roman A</p> <p>2016-01-01</p> <p>While the focus of attempts to classify cell <span class="hlt">death</span> programs has finally shifted in 2010s from microscopy-based morphological characteristics to biochemical assays, more recent discoveries have put the underlying assumptions of many such assays under severe stress, mostly because of the limited specificity of the assays. On the other hand, proteomics can quantitatively measure the abundances of thousands of proteins in a single experiment. Thus proteomics could develop a modern alternative to both semiquantitative morphology assessment as well as single-molecule biochemical assays. Here we tested this hypothesis by analyzing the proteomes of cells dying after been treated with various chemical agents. The most striking finding is that, for a multivariate model based on the proteome changes in three cells lines, the regulation patterns of the 200–500 most abundant proteins typically attributed to household type more accurately reflect that of the proteins directly interacting with the drug than any other protein subset grouped by common function or biological process, including cell <span class="hlt">death</span>. This is in broad agreement with the 'rigid cell <span class="hlt">death</span> mechanics' model where drug action mechanism and morphological changes caused by it are bijectively <span class="hlt">linked</span>. This finding, if confirmed, will open way for a broad use of proteomics in <span class="hlt">death</span> modality assessment. PMID:27752363</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29703263','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29703263"><span>Zika virus-induced hyper excitation precedes <span class="hlt">death</span> of mouse primary neuron.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gaburro, Julie; Bhatti, Asim; Sundaramoorthy, Vinod; Dearnley, Megan; Green, Diane; Nahavandi, Saeid; Paradkar, Prasad N; Duchemin, Jean-Bernard</p> <p>2018-04-27</p> <p>Zika virus infection in new born is <span class="hlt">linked</span> to congenital syndromes, especially microcephaly. Studies have shown that these neuropathies are the result of significant <span class="hlt">death</span> of neuronal progenitor cells in the central nervous system of the embryo, targeted by the virus. Although cell <span class="hlt">death</span> via apoptosis is well acknowledged, little is known about possible pathogenic cellular mechanisms triggering cell <span class="hlt">death</span> in neurons. We used in vitro embryonic mouse primary neuron cultures to study possible upstream cellular mechanisms of cell <span class="hlt">death</span>. Neuronal networks were grown on microelectrode array and electrical activity was recorded at different times post Zika virus infection. In addition to this method, we used confocal microscopy and Q-PCR techniques to observe morphological and molecular changes after infection. Zika virus infection of mouse primary neurons triggers an early spiking excitation of neuron cultures, followed by dramatic loss of this activity. Using NMDA receptor antagonist, we show that this excitotoxicity mechanism, likely via glutamate, could also contribute to the observed nervous system defects in human embryos and could open new perspective regarding the causes of adult neuropathies. This model of excitotoxicity, in the context of neurotropic virus infection, highlights the significance of neuronal activity recording with microelectrode array and possibility of more than one lethal mechanism after Zika virus infection in the nervous system.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22439942-docosahexaenoic-acid-counteracts-attenuation-cd95-induced-cell-death-inorganic-mercury','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22439942-docosahexaenoic-acid-counteracts-attenuation-cd95-induced-cell-death-inorganic-mercury"><span>Docosahexaenoic acid counteracts attenuation of CD95-induced cell <span class="hlt">death</span> by inorganic mercury</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Gill, Randall; Lanni, Lydia; Jen, K.-L. Catherine</p> <p></p> <p>In the United States the principal environmental exposure to mercury is through dietary consumption of sea food. Although the mechanism by which low levels of mercury affect the nervous system is not well established, epidemiological studies suggest that low level exposure of pregnant women to dietary mercury can adversely impact cognitive development in their children, but that Docosahexaenoic acid (DHA), the most prominent n-polyunsaturated fatty acid (n-PUFA) present in fish may counteract negative effects of mercury on the nervous system. Aside from effects on the nervous system, epidemiological and animal studies have also suggested that low level mercury exposure maymore » be a risk factor for autoimmune disease. However unlike the nervous system where a mechanism <span class="hlt">linking</span> mercury to impaired cognitive development remains elusive, we have previously suggested a potential mechanism <span class="hlt">linking</span> low level mercury exposures to immune system dysfunction and autoimmunity. In the immune system it is well established that disruption of CD95 mediated apoptosis leads to autoimmune disease. We have previously shown in vitro as well as in vivo that in lymphocytes burdened with low levels of mercury, CD95 mediated cell <span class="hlt">death</span> is impaired. In this report we now show that DHA counteracts the negative effect of mercury on CD95 signaling in T lymphocytes. T cells which have been pre-exposed to DHA are able to cleave pro-caspase 3 and efficiently signal programmed cell <span class="hlt">death</span> through the CD95 signaling pathway, whether or not they are burdened with low levels of mercury. Thus DHA may lower the risk of autoimmune disease after low level mercury exposures. - Highlights: • Inorganic mercury (Hg{sup 2+}) interferes with CD95 mediated cell <span class="hlt">death</span> in Jurkat T cells • DHA restores the ability of CD95 to signal cell <span class="hlt">death</span> in Hg{sup 2+} intoxicated T cells • The restoration of CD95 mediated cell <span class="hlt">death</span> by DHA is correlated with increased activation of Caspase 3.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=challenges+AND+big+AND+data&pg=4&id=ED507377','ERIC'); return false;" href="https://eric.ed.gov/?q=challenges+AND+big+AND+data&pg=4&id=ED507377"><span>High School Mentors in Brief: Findings from the Big Brothers Big <span class="hlt">Sisters</span> School-Based Mentoring Impact Study. P/PV In Brief. Issue 8</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Jucovy, Linda; Herrera, Carla</p> <p>2009-01-01</p> <p>This issue of "Public/Private Ventures (P/PV) In Brief" is based on "High School Students as Mentors," a report that examined the efficacy of high school mentors using data from P/PV's large-scale random assignment impact study of Big Brothers Big <span class="hlt">Sisters</span> school-based mentoring programs. The brief presents an overview of the findings, which…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=The+AND+Seven+AND+Sisters&id=EJ746983','ERIC'); return false;" href="https://eric.ed.gov/?q=The+AND+Seven+AND+Sisters&id=EJ746983"><span>The Pedagogy and Problems of Jane Andrews's "The Seven Little <span class="hlt">Sisters</span> Who Live on the Round Ball that Floats in the Air" (1861)</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tedesco, Laureen</p> <p>2006-01-01</p> <p>This essay examines the interplay between Jane Andrews's purpose and her pedagogy in "The Seven Little <span class="hlt">Sisters</span> Who Live on the Round Ball that Floats in the Air." The book demonstrates the teaching strategies she learned at the First State Normal in Massachusetts, moving from what the child knows to new material, engaging the child in…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19340674','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19340674"><span>Preventing <span class="hlt">death</span> among the recently incarcerated: an argument for naloxone prescription before release.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wakeman, Sarah E; Bowman, Sarah E; McKenzie, Michelle; Jeronimo, Alexandra; Rich, Josiah D</p> <p>2009-01-01</p> <p><span class="hlt">Death</span> from opiate overdose is a tremendous source of mortality, with a heightened risk in the weeks following incarceration. The goal of this study is to assess overdose experience and response among long-term opiate users involved in the criminal justice system. One hundred thirty-seven subjects from a project <span class="hlt">linking</span> opiate-dependent individuals being released from prison with methadone maintenance programs were asked 73 questions regarding overdose. Most had experienced and witnessed multiple overdoses; 911 was often not called. The majority of personal overdoses occurred within 1 month of having been institutionalized. Nearly all participants expressed an interest in being trained in overdose prevention with Naloxone. The risk of <span class="hlt">death</span> from overdose is greatly increased in the weeks following release from prison. A pre-release program of overdose prevention education, including Naloxone prescription, for inmates with a history of opiate addiction would likely prevent many overdose <span class="hlt">deaths</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20232130','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20232130"><span>Birth order and ratio of brothers to <span class="hlt">sisters</span> in Spanish transsexuals.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gómez-Gil, Esther; Esteva, Isabel; Carrasco, Rocío; Almaraz, M Cruz; Pasaro, Eduardo; Salamero, Manel; Guillamon, Antonio</p> <p>2011-06-01</p> <p>Three Western studies have shown that male-to-female (MF) homosexual transsexuals tend to be born later than their siblings and to come from sibships with more brothers than <span class="hlt">sisters</span>. The objective of this study was to determine whether these variables would be replicated in 530 MF and female-to-male (FM) Spanish transsexuals according to sexual orientation. The results showed that MF homosexual transsexuals had significantly more older brothers than the non-homosexual MF group. Compared with the expected rates in the general population, birth order was significantly higher in both MF (Slater's Index = 0.59; Fraternal Index = 0.61; Sororal Index = 0.58) and FM homosexual transsexuals (Slater's Index = 0.65; Fraternal Index = 0.68; Sororal Index = 0.67), and sibling sex ratio was significantly higher than expected in homosexual MF (sex ratio = 0.55) but not in homosexual FM transsexuals. No significant differences were found in the non-homosexual subgroups. The replication of the later birth order and sibling sex-ratio effect in MF homosexual transsexuals corroborates previous findings in a variety of groups from different cultures and may suggest a common mechanism underlying the etiology of transsexualism.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22045850','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22045850"><span>Mortality in parents following the <span class="hlt">death</span> of a child: a nationwide follow-up study from Sweden.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rostila, Mikael; Saarela, Jan; Kawachi, Ichiro</p> <p>2012-10-01</p> <p>The <span class="hlt">death</span> of a young child is so devastating that it can increase the risk of mortality in the grieving parent. Little is known about the impact of an adult child's <span class="hlt">death</span> on the health of parents. The authors conducted a follow-up study between 1980 and 2002 based on a <span class="hlt">linked</span>-registers database that contains the total Swedish population. The authors examined mortality from all causes, natural causes and unnatural causes among parents following the <span class="hlt">death</span> of children aged 10-49 years. An increased mortality risk (RR 1.31, 95% CI 1.02 to 1.68) in mothers following the <span class="hlt">death</span> of a minor child (10-17 years) was found and especially following unnatural <span class="hlt">deaths</span> (primarily accidents and suicides). Mothers also experienced elevated mortality following the <span class="hlt">death</span> of an adult child aged 18-25 years (RR 1.15, 95% CI 1.03 to 1.29). Bereavement effects among fathers were more attenuated and chiefly found after >8 years of follow-up. From a short-term perspective (1-3 years), the <span class="hlt">death</span> of an adult child (>25 years) was somewhat protective for parents. However, over longer follow-up periods, it approached (4-8 years) and exceeded (>8 years) the <span class="hlt">death</span> risk of the general population. These findings corroborate and extend earlier findings suggesting elevated mortality risks also following the <span class="hlt">death</span> of an adult child.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26596625','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26596625"><span>Extracting phylogenetic signal and accounting for bias in whole-genome data sets supports the Ctenophora as <span class="hlt">sister</span> to remaining Metazoa.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Borowiec, Marek L; Lee, Ernest K; Chiu, Joanna C; Plachetzki, David C</p> <p>2015-11-23</p> <p>Understanding the phylogenetic relationships among major lineages of multicellular animals (the Metazoa) is a prerequisite for studying the evolution of complex traits such as nervous systems, muscle tissue, or sensory organs. Transcriptome-based phylogenies have dramatically improved our understanding of metazoan relationships in recent years, although several important questions remain. The branching order near the base of the tree, in particular the placement of the poriferan (sponges, phylum Porifera) and ctenophore (comb jellies, phylum Ctenophora) lineages is one outstanding issue. Recent analyses have suggested that the comb jellies are <span class="hlt">sister</span> to all remaining metazoan phyla including sponges. This finding is surprising because it suggests that neurons and other complex traits, present in ctenophores and eumetazoans but absent in sponges or placozoans, either evolved twice in Metazoa or were independently, secondarily lost in the lineages leading to sponges and placozoans. To address the question of basal metazoan relationships we assembled a novel dataset comprised of 1080 orthologous loci derived from 36 publicly available genomes representing major lineages of animals. From this large dataset we procured an optimized set of partitions with high phylogenetic signal for resolving metazoan relationships. This optimized data set is amenable to the most appropriate and computationally intensive analyses using site-heterogeneous models of sequence evolution. We also employed several strategies to examine the potential for long-branch attraction to bias our inferences. Our analyses strongly support the Ctenophora as the <span class="hlt">sister</span> lineage to other Metazoa. We find no support for the traditional view uniting the ctenophores and Cnidaria. Our findings are supported by Bayesian comparisons of topological hypotheses and we find no evidence that they are biased by long-branch attraction. Our study further clarifies relationships among early branching metazoan lineages</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/6865499','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/6865499"><span>Cyclophosphamide-induced in vivo <span class="hlt">sister</span> chromatid exchange in Mus Musculus. II: Effect of age and genotype on <span class="hlt">sister</span> chromatid exchange, micronuclei and metaphase index.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Reimer, D L; Singh, S M</p> <p>1983-01-01</p> <p>In vivo cyclophosphamide-induced <span class="hlt">sister</span> chromatid exchanges (SCEs) micronuclei, and metaphase indices were assessed in two age groups (10.8 +/- 0.9 weeks' an 33.1 +/- 1.3 weeks' old) of female mice from three genetic strains (C3H/S, C57BL/6J, and Balb/c). In general, older animals showed diminished SCE induction over their younger counterparts. The relative difference between individuals of the two ages is strain-dependent. Unlike C57BL/6J and Balb/c, strain C3H/S showed significantly lower SCE values in the older animals at every cyclophosphamide treatment. It may reflect on the possible involvement of genetic determinant(s) for the component(s) of SCE formation during aging. Frequencies of micronuclei, however, were consistently higher in older animals than in their younger counterparts. Furthermore, cytotoxicity of cyclophosphamide, as reflected in metaphase indices, was also higher in older animals. Lower metaphase indices associated with higher micronuclei levels in older individuals may suggest a decline in the rate of cellular replication in these animals. Furthermore, the lower metaphase indices associated with lower SCE values, and increasing micronuclei levels accompanied by decreasing SCE frequencies in older animals, may reflect reduced DNA repair ability during aging. These results support the hypothesis of genotype-dependent decline in the rate of DNA repair and replication during aging, particularly under stressed conditions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27983897','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27983897"><span>A Comparison of Trans Women, Trans Men, Genderqueer Individuals, and Cisgender Brothers and <span class="hlt">Sisters</span> on the Bem Sex-Role Inventory: Ratings by Self and Siblings.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Factor, Rhonda J; Rothblum, Esther D</p> <p>2017-01-01</p> <p>A U.S. national sample of 295 transgender adults (trans women, trans men, and genderqueer individuals) and their cisgender siblings completed the Bem Sex-Role Inventory about their siblings as well as themselves, which enabled a comparison between self-perceptions and sibling's perceptions of personality characteristics. Self-reported personality characteristics scored as feminine of trans women were not statistically different from those of their cisgender <span class="hlt">sisters</span>, but they were significantly higher than self-reported femininity scores of trans men, genderqueer individuals, and cisgender brothers. Self-reported personality characteristics scored as masculine of trans men did not differ significantly from those of their cisgender brothers, but they were higher than those of trans women. Trans men and cisgender brothers were viewed by their siblings in a more sex-typed way than they rated themselves, whereas trans women and cisgender <span class="hlt">sisters</span> were rated by their siblings in a less sex-typed way than they viewed themselves.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27747997','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27747997"><span>The Effect of Widowhood on Mental Health - an Analysis of Anticipation Patterns Surrounding the <span class="hlt">Death</span> of a Spouse.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Siflinger, Bettina</p> <p>2017-12-01</p> <p>This study explores the effects of widowhood on mental health by taking into account the anticipation and adaptation to the partner's <span class="hlt">death</span>. The empirical analysis uses representative panel data from the USA that are <span class="hlt">linked</span> to administrative <span class="hlt">death</span> records of the National <span class="hlt">Death</span> Index. I estimate static and dynamic specifications of the panel probit model in which unobserved heterogeneity is modeled with correlated random effects. I find strong anticipation effects of the partner's <span class="hlt">death</span> on the probability of depression, implying that the partner's <span class="hlt">death</span> event cannot be assumed to be exogenous in econometric models. In the absence of any anticipation effects, the partner's <span class="hlt">death</span> has long-lasting mental health consequences, leading to a significantly slower adaptation to widowhood. The results suggest that both anticipation effects and adaptation effects can be attributed to a caregiver burden and to the cause of <span class="hlt">death</span>. The findings of this study have important implications for designing adequate social policies for the elderly US population that alleviate the negative consequences of bereavement. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26946528','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26946528"><span>Differences in mycorrhizal communities between Epipactis palustris, E. helleborine and its presumed <span class="hlt">sister</span> species E. neerlandica.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Jacquemyn, Hans; Waud, Michael; Lievens, Bart; Brys, Rein</p> <p>2016-07-01</p> <p>In orchid species that have populations occurring in strongly contrasting habitats, mycorrhizal divergence and other habitat-specific adaptations may lead to the formation of reproductively isolated taxa and ultimately to species formation. However, little is known about the mycorrhizal communities associated with recently diverged <span class="hlt">sister</span> taxa that occupy different habitats. In this study, 454 amplicon pyrosequencing was used to investigate mycorrhizal communities associating with Epipactis helleborine in its typical forest habitat and with its presumed <span class="hlt">sister</span> species E. neerlandica that almost exclusively occurs in coastal dune habitats. Samples of the phylogenetically more distant E. palustris, which co-occurred with E. neerlandica, were also included to investigate the role of habitat-specific conditions on mycorrhizal communities. A total of 105 operational taxonomic units (OTUs) of putative orchid mycorrhizal fungi were observed in the three studied species. The majority of these fungi were endophytic fungi of Helotiales and ectomycorrhizal fungi belonging to Thelephoraceae, Sebacinaceae and Inocybaceae. In addition, a large number of other ectomycorrhizal taxa were detected, including Cortinarius, Cenococcum, Tuber, Geopora, Wilcoxina, Meliniomyces, Hebeloma, Tricholoma, Russula and Peziza Mycorrhizal communities differed significantly between the three species, but differences were most pronounced between the forest species (E. helleborine) and the two dune slack species (E. neerlandica and E. palustris). The results clearly showed that recently diverged orchid species that occupy different habitats were characterized by significantly different mycorrhizal communities and call for more detailed experiments that aim at elucidating the contribution of habitat-specific adaptations in general and mycorrhizal divergence in particular to the process of speciation in orchids. © The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17998801','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17998801"><span>Clinical cosmobiology: distribution of <span class="hlt">deaths</span> during 180 months and cosmophysical activity. The Lithuanian study, 1990-2004. The role of cosmic rays.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stoupel, Elyiahu; Kalediene, Ramune; Petrauskiene, Jadvyga; Starkuviene, Skirmante; Abramson, Evgeny; Israelevich, Peter; Sulkes, Jaqueline</p> <p>2007-01-01</p> <p>The aim of this study is a next step of our previous, initial, publications--to explore the <span class="hlt">links</span> between monthly <span class="hlt">death</span> number (total, and for the major <span class="hlt">death</span> causes and each gender) with levels of monthly cosmophysical activity in a long-term, big cohort observation. <span class="hlt">Death</span> number during 180 consecutive months from the National Registry of Lithuania for years 1990-2004 were studied. A total of 630,205 <span class="hlt">deaths</span> were analyzed (333,035 males). For comparison, monthly indices of solar activity, geomagnetic activity, and cosmic ray activity and year and month (1-12) of the study were used. The cosmophysical data were obtained from space research centers in the USA, Russia, and Finland. Statistics. Pearson correlation coefficients (r) and their probabilities (P) between compared parameters were calculated. A multivariate model of prediction was designed. It was a significant correlation between total monthly <span class="hlt">death</span> number and indices of cosmic ray activity and, inverse, of solar activity; in men stronger than in women. Monthly geomagnetic activity was significantly correlated with traffic accidents, ischemic heart disease/stroke ratio, suicide victim number. <span class="hlt">Deaths</span> from stroke, noncardiovascular causes, suicide, traffic accidents were related with cosmic ray activity and, inverse, with solar activity. Relationship of ischemic heart disease/stroke ratio to year of observation showed additional evidence for the growing role of stroke in cardiovascular mortality. Monthly <span class="hlt">death</span> number is <span class="hlt">linked</span> to cosmic ray activity, and inverse, to solar activity. Central place of stroke-related <span class="hlt">deaths</span> in cardiovascular mortality is emerging. Geomagnetic activity, in monthly account, plays a relatively minor role. We presume that forces antagonistic to cosmic ray activity, like solar activity and geomagnetic activity, can prevent some negative biologic effects of cosmic ray.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22296949','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22296949"><span>A 'beautiful <span class="hlt">death</span>': mortality, <span class="hlt">death</span>, and holidays in a Mexican municipality.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wilches-Gutiérrez, José L; Arenas-Monreal, Luz; Paulo-Maya, Alfredo; Peláez-Ballestas, Ingris; Idrovo, Alvaro J</p> <p>2012-03-01</p> <p>Several studies have reported increased mortality during holidays. Using a cultural epidemiological, sequential mixed-methods approach, this study explored holiday-related trends using mortality data from Yautepec (Morelos, Mexico) collected between 1986 and 2008 (N=5027 <span class="hlt">deaths</span>). This analysis found that mortality increased on Christmas Day and All Saints' Day. Mortality increased on Candlemas Day among women, and increased on New Year's Day among men. More <span class="hlt">deaths</span> caused by cardiovascular disease among women and traumatic injuries among men occurred during holidays than in non-holiday periods. To ascertain the elements comprising the health/illness/<span class="hlt">death</span> process in the context of a holiday in this municipality, we conducted semi-structured interviews in March and April 2009 with relatives of seven individuals who had died during holidays in the previous 4 years (N=11); data from these interviews were analyzed from a grounded theory perspective to ascertain common conceptual themes. The "beautiful <span class="hlt">death</span>" emerged as the main concept in the interpretation of <span class="hlt">death</span>; this concept was related to the expectation of a good <span class="hlt">death</span> and the particularly special nature of <span class="hlt">death</span> during a holiday because of the involvement of religious entities, such as God, the Virgin Mary, and/or a saint, at the moment of <span class="hlt">death</span>. Quantitative and qualitative results provided information about the important effects of holidays, culture, and religious belief on mortality patterns within a Mexican context, and contributed to a better understanding of the relationships among mortality, the nature of <span class="hlt">death</span>, and holidays. Our results suggest that, in the studied region, <span class="hlt">death</span> can be interpreted as a "beautiful process". More research is needed to explore this process in other similar contexts and to address topics related to the care and attention given the dying person and the expectation of a good <span class="hlt">death</span>. Copyright © 2012 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4515646','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4515646"><span>The Role of <span class="hlt">Sister</span> Cities’ Staff Exchanges in Developing “Learning Cities”: Exploring Necessary and Sufficient Conditions in Social Capital Development Utilizing Proportional Odds Modeling</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Buckley, Patrick Henry; Takahashi, Akio; Anderson, Amy</p> <p>2015-01-01</p> <p>In the last half century former international adversaries have become cooperators through networking and knowledge sharing for decision making aimed at improving quality of life and sustainability; nowhere has this been more striking then at the urban level where such activity is seen as a key component in building “learning cities” through the development of social capital. Although mega-cities have been leaders in such efforts, mid-sized cities with lesser resource endowments have striven to follow by focusing on more frugal <span class="hlt">sister</span> city type exchanges. The underlying thesis of our research is that great value can be derived from city-to-city exchanges through social capital development. However, such a study must differentiate between necessary and sufficient conditions. Past studies assumed necessary conditions were met and immediately jumped to demonstrating the existence of structural relationships by measuring networking while further assuming that the existence of such demonstrated a parallel development of cognitive social capital. Our research addresses this lacuna by stepping back and critically examining these assumptions. To accomplish this goal we use a Proportional Odds Modeling with a Cumulative Logit <span class="hlt">Link</span> approach to demonstrate the existence of a common latent structure, hence asserting that necessary conditions are met. PMID:26114245</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Religious+AND+sacred&pg=2&id=EJ1071273','ERIC'); return false;" href="https://eric.ed.gov/?q=Religious+AND+sacred&pg=2&id=EJ1071273"><span>Mobilising Mother Cabrini's Educational Practice: The Transnational Context of the London School of the Missionary <span class="hlt">Sisters</span> of the Sacred Heart of Jesus 1898-1911</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Williams, Maria Patricia</p> <p>2015-01-01</p> <p>A schoolteacher from Lombardy, Saint Frances Xavier Cabrini (1850-1917), founded the Institute of Missionary <span class="hlt">Sisters</span> of the Sacred Heart of Jesus (MSC) in 1880. It was one of the 185 female religious institutes established in Italy in the nineteenth century. In the newly unified Italy, Cabrini found opportunities to formulate progressive Catholic…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27756839','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27756839"><span>Necroptosis-like Neuronal Cell <span class="hlt">Death</span> Caused by Cellular Cholesterol Accumulation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Funakoshi, Takeshi; Aki, Toshihiko; Tajiri, Masateru; Unuma, Kana; Uemura, Koichi</p> <p>2016-11-25</p> <p>Aberrant cellular accumulation of cholesterol is associated with neuronal lysosomal storage disorders such as Niemann-Pick disease Type C (NPC). We have shown previously that l-norephedrine (l-Nor), a sympathomimetic amine, induces necrotic cell <span class="hlt">death</span> associated with massive cytoplasmic vacuolation in SH-SY5Y human neuroblastoma cells. To reveal the molecular mechanism underling necrotic neuronal cell <span class="hlt">death</span> caused by l-Nor, we examined alterations in the gene expression profile of cells during l-Nor exposure. DNA microarray analysis revealed that the gene levels for cholesterol transport (LDL receptor and NPC2) as well as cholesterol biosynthesis (mevalonate pathway enzymes) are increased after exposure to 3 mm l-Nor for ∼6 h. Concomitant with this observation, the master transcriptional regulator of cholesterol homeostasis, SREBP-2, is activated by l-Nor. The increase in cholesterol uptake as well as biosynthesis is not accompanied by an increase in cholesterol in the plasma membrane, but rather by aberrant accumulation in cytoplasmic compartments. We also found that cell <span class="hlt">death</span> by l-Nor can be suppressed by nec-1s, an inhibitor of a regulated form of necrosis, necroptosis. Abrogation of SREBP-2 activation by the small molecule inhibitor betulin or by overexpression of dominant-negative SREBP-2 efficiently reduces cell <span class="hlt">death</span> by l-Nor. The mobilization of cellular cholesterol in the presence of cyclodextrin also suppresses cell <span class="hlt">death</span>. These results were also observed in primary culture of striatum neurons. Taken together, our results indicate that the excessive uptake as well as synthesis of cholesterol should underlie neuronal cell <span class="hlt">death</span> by l-Nor exposure, and suggest a possible <span class="hlt">link</span> between lysosomal cholesterol storage disorders and the regulated form of necrosis in neuronal cells. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5122773','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5122773"><span>Necroptosis-like Neuronal Cell <span class="hlt">Death</span> Caused by Cellular Cholesterol Accumulation*</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Funakoshi, Takeshi; Aki, Toshihiko; Tajiri, Masateru; Unuma, Kana; Uemura, Koichi</p> <p>2016-01-01</p> <p>Aberrant cellular accumulation of cholesterol is associated with neuronal lysosomal storage disorders such as Niemann-Pick disease Type C (NPC). We have shown previously that l-norephedrine (l-Nor), a sympathomimetic amine, induces necrotic cell <span class="hlt">death</span> associated with massive cytoplasmic vacuolation in SH-SY5Y human neuroblastoma cells. To reveal the molecular mechanism underling necrotic neuronal cell <span class="hlt">death</span> caused by l-Nor, we examined alterations in the gene expression profile of cells during l-Nor exposure. DNA microarray analysis revealed that the gene levels for cholesterol transport (LDL receptor and NPC2) as well as cholesterol biosynthesis (mevalonate pathway enzymes) are increased after exposure to 3 mm l-Nor for ∼6 h. Concomitant with this observation, the master transcriptional regulator of cholesterol homeostasis, SREBP-2, is activated by l-Nor. The increase in cholesterol uptake as well as biosynthesis is not accompanied by an increase in cholesterol in the plasma membrane, but rather by aberrant accumulation in cytoplasmic compartments. We also found that cell <span class="hlt">death</span> by l-Nor can be suppressed by nec-1s, an inhibitor of a regulated form of necrosis, necroptosis. Abrogation of SREBP-2 activation by the small molecule inhibitor betulin or by overexpression of dominant-negative SREBP-2 efficiently reduces cell <span class="hlt">death</span> by l-Nor. The mobilization of cellular cholesterol in the presence of cyclodextrin also suppresses cell <span class="hlt">death</span>. These results were also observed in primary culture of striatum neurons. Taken together, our results indicate that the excessive uptake as well as synthesis of cholesterol should underlie neuronal cell <span class="hlt">death</span> by l-Nor exposure, and suggest a possible <span class="hlt">link</span> between lysosomal cholesterol storage disorders and the regulated form of necrosis in neuronal cells. PMID:27756839</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1614804','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1614804"><span>Traumatic child <span class="hlt">death</span> and documented maltreatment history, Los Angeles.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sorenson, S B; Peterson, J G</p> <p>1994-01-01</p> <p>OBJECTIVES. Child abuse is a presumed but largely untested risk factor for child homicide. This research investigated the social and child protective service history of child homicide victims. METHODS. A pairwise matched case-control design was used to assess documented child maltreatment as a risk factor for homicide vs unintentional injury <span class="hlt">death</span>. Homicide victims aged 0 to 14 years were identified through Los Angeles Police Department case summaries. Control subjects (children who died of an unintentional injury) were matched to case subjects (children who died from homicide) by age, sex, race/ethnicity, and date of <span class="hlt">death</span>. Case and control subjects were <span class="hlt">linked</span> with county service records to determine any known history of maltreatment. RESULTS. A total of 220 children were homicide victims during 1978 through 1987 in the city of Los Angeles. Only one in six children who died (of homicide or unintentional injury) or his/her family was known to county social or child protective services prior to the <span class="hlt">death</span>. Recorded history of child protective services was associated with homicide victimization (adjusted odds ratio = 3.40, 95% confidence interval = 1.25, 9.27). CONCLUSIONS. Current service systems need assistance in identifying and protecting children at high risk of homicide. PMID:8154567</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4731302','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4731302"><span>Maternal obesity and gestational weight gain are risk factors for infant <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bodnar, Lisa M.; Siminerio, Lara L.; Himes, Katherine P.; Hutcheon, Jennifer A.; Lash, Timothy L.; Parisi, Sara M.; Abrams, Barbara</p> <p>2015-01-01</p> <p>Objective To assess the joint and independent relationships of gestational weight gain and prepregnancy body mass index (BMI) on risk of infant mortality. Methods We used Pennsylvania <span class="hlt">linked</span> birth-infant <span class="hlt">death</span> records (2003–2011) from infants without anomalies to underweight (n=58,973), normal weight (n=610,118), overweight (n=296,630), grade 1 obese (n=147,608), grade 2 obese (n=71,740), and grade 3 obese (n=47,277) mothers. Multivariable logistic regression models stratified by BMI category were used to estimate dose-response associations between z-scores of gestational weight gain and infant <span class="hlt">death</span> after confounder adjustment. Results Infant mortality risk was lowest among normal weight women and increased with rising BMI category. For all BMI groups except for grade 3 obesity, there were U-shaped associations between gestational weight gain and risk of infant <span class="hlt">death</span>. Weight loss and very low weight gain among women with grade 1 and 2 obesity were associated with high risks of infant mortality. However, even when gestational weight gain in women with obesity was optimized, the predicted risk of infant <span class="hlt">death</span> remained higher than that of normal weight women. Conclusions Interventions aimed at substantially reducing preconception weight among women with obesity and avoiding very low or very high gestational weight gain may reduce risk of infant <span class="hlt">death</span>. PMID:26572932</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21398096','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21398096"><span>Head circumference, apolipoprotein E genotype and cognition in the Bavarian School <span class="hlt">Sisters</span> Study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Perneczky, R; Alexopoulos, P; Wagenpfeil, S; Bickel, H; Kurz, A</p> <p>2012-04-01</p> <p>The apolipoprotein E (APOE) ɛ4 allele is correlated with an earlier onset of Alzheimer's disease symptoms; larger head circumference has been associated with an individual resilience against cognitive impairment. We explored if larger head circumference attenuates the effect of the APOE ɛ4 allele on cognition in 380 Catholic <span class="hlt">sisters</span> covering the spectrum from normal cognitive performance to severe dementia. Linear regression analysis, adjusting for risk factors for cognitive decline, revealed that APOE ɛ4 was correlated with worse cognition and that larger head circumference attenuated the negative effect of the ɛ4 allele on cognitive performance. Larger head circumference (i.e. larger brain size) seems to be associated with greater resilience against genetic determinants of cognitive impairment, possibly due to enhanced brain or cognitive reserve. Copyright © 2011 Elsevier Masson SAS. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5070874','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5070874"><span>Methylfolate Trap Promotes Bacterial Thymineless <span class="hlt">Death</span> by Sulfa Drugs</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pham, Thanh H.; Jakubowski, Hieronim; Wolff, Kerstin A.; Ogwang, Sam; Timpona, Joseph L.; Gogula, Soumya; Jacobs, Michael R.; Ruetz, Markus; Kräutler, Bernhard; Jacobsen, Donald W.; Zhang, Guo-Fang; Nguyen, Liem</p> <p>2016-01-01</p> <p>The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer’s dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, <span class="hlt">linking</span> the metabolism of folate, vitamin B12, methionine and homocysteine. However, the existence or physiological significance of this phenomenon has been unknown in bacteria, which synthesize folate de novo. Here we identify the methylfolate trap as a novel determinant of the bacterial intrinsic <span class="hlt">death</span> by sulfonamides, antibiotics that block de novo folate synthesis. Genetic mutagenesis, chemical complementation, and metabolomic profiling revealed trap-mediated metabolic imbalances, which induced thymineless <span class="hlt">death</span>, a phenomenon in which rapidly growing cells succumb to thymine starvation. Restriction of B12 bioavailability, required for preventing trap formation, using an “antivitamin B12” molecule, sensitized intracellular bacteria to sulfonamides. Since boosting the bactericidal activity of sulfonamides through methylfolate trap induction can be achieved in Gram-negative bacteria and mycobacteria, it represents a novel strategy to render these pathogens more susceptible to existing sulfonamides. PMID:27760199</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27021052','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27021052"><span>[From dualism to multiplicity: seeing BCL-2 family proteins and cell <span class="hlt">death</span> with new eyes].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Aouacheria, Abdel</p> <p>2015-01-01</p> <p>The concept of cell <span class="hlt">death</span> has many <span class="hlt">links</span> to the concept of <span class="hlt">death</span> itself, defined as the opposite of life. Achievements obtained through research on apoptosis have apparently allowed us to transcend this Manichean view. <span class="hlt">Death</span> is no longer outside, but rather inside living systems, as a constitutive force at work within the living matter. Whereas the <span class="hlt">death</span> of cells can be positive and breed "creation" (e.g. during morphogenesis), its dysregulation can also cause or contribute to fatal diseases including cancer. It is tempting to apply this biological discourse to illuminate the relations between life and <span class="hlt">death</span>, taken in general terms, but does this generalization actually hold? Is this discourse not essentially a metaphor? If cell <span class="hlt">death</span> is considered as a vital aspect of various biological processes, then are we not faced with some vitalistic conception of <span class="hlt">death</span>? Are there one or more meanings to the word "<span class="hlt">death</span>"? Does the power to self-destruct act in opposition to other key features of living entities, or rather in juxtaposition to them? In this article, we first describe how the field of cell <span class="hlt">death</span> has been developed on the basis of perceived and built dichotomies, mirroring the original opposition between life and <span class="hlt">death</span>. We detail the limitations of the current paradigm of apoptosis regulation by BCL-2 family proteins, which nicely illustrate the problem of binary thinking in biology. Last, we try to show a way out of this dualistic matrix, by drawing on the notions of multiplicity, complexity, diversity, evolution and contingency. © Société de Biologie, 2016.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27769227','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27769227"><span>Describing the linkages of the immigration, refugees and citizenship Canada permanent resident data and vital statistics <span class="hlt">death</span> registry to Ontario's administrative health database.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chiu, Maria; Lebenbaum, Michael; Lam, Kelvin; Chong, Nelson; Azimaee, Mahmoud; Iron, Karey; Manuel, Doug; Guttmann, Astrid</p> <p>2016-10-21</p> <p>Ontario, the most populous province in Canada, has a universal healthcare system that routinely collects health administrative data on its 13 million legal residents that is used for health research. Record linkage has become a vital tool for this research by enriching this data with the Immigration, Refugees and Citizenship Canada Permanent Resident (IRCC-PR) database and the Office of the Registrar General's Vital Statistics-<span class="hlt">Death</span> (ORG-VSD) registry. Our objectives were to estimate linkage rates and compare characteristics of individuals in the <span class="hlt">linked</span> versus unlinked files. We used both deterministic and probabilistic linkage methods to <span class="hlt">link</span> the IRCC-PR database (1985-2012) and ORG-VSD registry (1990-2012) to the Ontario's Registered Persons Database. Linkage rates were estimated and standardized differences were used to assess differences in socio-demographic and other characteristics between the <span class="hlt">linked</span> and unlinked records. The overall linkage rates for the IRCC-PR database and ORG-VSD registry were 86.4 and 96.2 %, respectively. The majority (68.2 %) of the record linkages in IRCC-PR were achieved after three deterministic passes, 18.2 % were <span class="hlt">linked</span> probabilistically, and 13.6 % were unlinked. Similarly the majority (79.8 %) of the record linkages in the ORG-VSD were <span class="hlt">linked</span> using deterministic record linkage, 16.3 % were <span class="hlt">linked</span> after probabilistic and manual review, and 3.9 % were unlinked. Unlinked and <span class="hlt">linked</span> files were similar for most characteristics, such as age and marital status for IRCC-PR and sex and most causes of <span class="hlt">death</span> for ORG-VSD. However, lower linkage rates were observed among people born in East Asia (78 %) in the IRCC-PR database and certain causes of <span class="hlt">death</span> in the ORG-VSD registry, namely perinatal conditions (61.3 %) and congenital anomalies (81.3 %). The linkages of immigration and vital statistics data to existing population-based healthcare data in Ontario, Canada will enable many novel cross-sectional and longitudinal studies to</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17077407','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17077407"><span>Ascertainment of Hispanic ethnicity on California <span class="hlt">death</span> certificates: implications for the explanation of the Hispanic mortality advantage.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Eschbach, Karl; Kuo, Yong-Fang; Goodwin, James S</p> <p>2006-12-01</p> <p>We determined the size and correlates of underascertainment of Hispanic ethnicity on California <span class="hlt">death</span> certificates. We used 1999 to 2000 vital registration data. We compared Hispanic ethnicity reported on the <span class="hlt">death</span> certificate to Hispanic ethnicity derived from birthplace for the foreign-born and an algorithm that used first and last name and percentage of Hispanics in the county of residence for the US-born. We validated <span class="hlt">death</span> certificate nativity by comparing data with that in <span class="hlt">linked</span> Social Security Administration records. Ethnicity and birthplace information was concordant for foreign-born Hispanics, who have mortality rates that are 25% to 30% lower than those of non-Hispanic Whites. <span class="hlt">Death</span> certificates likely underascertain <span class="hlt">deaths</span> of US-born Hispanics, particularly at older ages, for persons with more education, and in census tracts with lower percentages of Hispanics. Conservative correction for under-ascertainment eliminates the Hispanic mortality advantage for US-born men. Hispanic ethnicity is accurately ascertained on the California <span class="hlt">death</span> certificate for immigrants. Immigrant Hispanics have lower age-adjusted mortality rates than do non-Hispanic Whites. For US-born Hispanics, the mortality advantage compared with non-Hispanic Whites is smaller and may be explained by underreporting of Hispanic ethnicity on the <span class="hlt">death</span> certificate.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://kidshealth.org/en/teens/someone-died.html','NIH-MEDLINEPLUS'); return false;" href="https://kidshealth.org/en/teens/someone-died.html"><span><span class="hlt">Death</span> and Grief</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... Staying Safe Videos for Educators Search English Español <span class="hlt">Death</span> and Grief KidsHealth / For Teens / <span class="hlt">Death</span> and Grief What's in this article? What Is ... the reaction we have in response to a <span class="hlt">death</span> or loss. Grief can affect our body, mind, ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=death&pg=2&id=EJ1005425','ERIC'); return false;" href="https://eric.ed.gov/?q=death&pg=2&id=EJ1005425"><span>A <span class="hlt">Death</span> in the Family: <span class="hlt">Death</span> as a Zen Concept</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Black, Helen K.; Rubinstein, Robert L.</p> <p>2013-01-01</p> <p>This study is based on original research that explored family reaction to the <span class="hlt">death</span> of an elderly husband and father. We interviewed 34 families (a family included a widow and two adult biological children) approximately 6 to 10 months after the <span class="hlt">death</span>. In one-on-one interviews, we discussed family members' initial reaction to the <span class="hlt">death</span>, how the…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19891','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19891"><span>Synthetic activation of caspases: Artificial <span class="hlt">death</span> switches</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>MacCorkle, Rebecca A.; Freeman, Kevin W.; Spencer, David M.</p> <p>1998-01-01</p> <p>The development of safe vectors for gene therapy requires fail-safe mechanisms to terminate therapy or remove genetically altered cells. The ideal “suicide switch” would be nonimmunogenic and nontoxic when uninduced and able to trigger cell <span class="hlt">death</span> independent of tissue type or cell cycle stage. By using chemically induced dimerization, we have developed powerful <span class="hlt">death</span> switches based on the cysteine proteases, caspase-1 ICE (interleukin-1β converting enzyme) and caspase-3 YAMA. In both cases, aggregation of the target protein is achieved by a nontoxic lipid-permeable dimeric FK506 analog that binds to the attached FK506-binding proteins, FKBPs. We find that intracellular cross-<span class="hlt">linking</span> of caspase-1 or caspase-3 is sufficient to trigger rapid apoptosis in a Bcl-xL-independent manner, suggesting that these conditional proapoptotic molecules can bypass intracellular checkpoint genes, such as Bcl-xL, that limit apoptosis. Because these chimeric molecules are derived from autologous proteins, they should be nonimmunogenic and thus ideal for long-lived gene therapy vectors. These properties should also make chemically induced apoptosis useful for developmental studies, for treating hyperproliferative disorders, and for developing animal models to a wide variety of diseases. PMID:9520421</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3756551','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3756551"><span>Seasonality and Coronary Heart Disease <span class="hlt">Deaths</span> in United States Firefighters</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mbanu, Ibeawuchi; Wellenius, Gregory A.; Mittleman, Murray A.; Peeples, Lynne; Stallings, Leonard A.; Kales, Stefanos N.</p> <p>2013-01-01</p> <p>United States firefighters have a high on-duty fatality rate and coronary heart disease is the leading cause. Seasonality affects the incidence of cardiovascular events in the general population, but its effects on firefighters are unknown. We statistically examined the seasonal and annual variation of all on-duty coronary heart disease <span class="hlt">deaths</span> among US firefighters between 1994 and 2004 using the chi-square distribution and Poisson regression model of the monthly fatality counts. We also examined the effect of ambient temperature (apparent as well as wind chill temperature) on coronary heart disease fatalities during the study span using a time-stratified, case-crossover study design. When grouped by season, we observed the distribution of the 449 coronary heart disease fatalities to show a relative peak in winter (32%) and relative nadir in spring (21%). This pattern was significantly different (p=0.005) from the expected distribution under the null hypothesis where season has no effect. The pattern persisted in additional analyses, stratifying the <span class="hlt">deaths</span> by the type of duty in which the firefighters were engaged at the time of their <span class="hlt">deaths</span>. In the Poisson regression model of the monthly fatality counts, the overall goodness-of-fit between the actual and predicted case counts was excellent ( χ42 = 16.63; p = 0.002). Two distinct peaks were detected, one in January-February and the other in August-September. Overall, temperature was not associated with increased risk of on-duty <span class="hlt">death</span>. After allowing for different effects of temperature in mild/hot versus cold periods, a 1°C increase was not protective in cold weather, nor did it increase the risk of <span class="hlt">death</span> in warmer weather. The findings of this study reveal statistical evidence for excess coronary heart disease <span class="hlt">deaths</span> among firefighters during winter; however, the temporal pattern coronary heart disease <span class="hlt">deaths</span> was not <span class="hlt">linked</span> to temperature variation. We also found the seasonal pattern to be independent of duty</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4421018','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4421018"><span>Zinc deficiency mediates alcohol-induced apoptotic cell <span class="hlt">death</span> in the liver of rats through activating ER and mitochondrial cell <span class="hlt">death</span> pathways</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sun, Qian; Zhong, Wei; Zhang, Wenliang; Li, Qiong; Sun, Xiuhua; Tan, Xiaobing; Sun, Xinguo; Dong, Daoyin</p> <p>2015-01-01</p> <p>Hepatic zinc deficiency has been well documented in alcoholic patients, but the mechanisms by which zinc deficiency mediates cell <span class="hlt">death</span> have not been well defined. The objectives of this study were to determine whether alcohol perturbs subcellular zinc homeostasis and how organelle zinc depletion may <span class="hlt">link</span> with cell <span class="hlt">death</span> pathways. Wistar rats were pair-fed with the Lieber-DeCarli control or ethanol diet for 5 mo. Chronic alcohol exposure significantly reduced zinc level in isolated hepatic endoplasmic reticulum (ER) and mitochondria. Among the detected zinc transporters, ER Zrt/Irt-like protein (ZIP)13 and mitochondrial ZIP8, which transport zinc from ER and mitochondria to cytosol, were significantly increased. Mitochondrial zinc transporter (ZnT) 4, which transports zinc from cytosol to mitochondria, was also increased. ER phosphorylated eukaryotic initiation factor 2α, activating transcription factor 4, and C/EBP homologous protein were significantly upregulated, and mitochondrial cytochrome c release and Bax insertion were detected in association with caspase-3 activation and apoptotic cell <span class="hlt">death</span>. To define the role of zinc deficiency in ER and mitochondrial stress, H4IIEC3 cells were treated with 3 μM N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine for 6 h with or without supplementation with zinc or N-acetylcysteine (NAC). The results demonstrated that zinc deprivation induced caspase-3 activation and apoptosis in association with ER and mitochondria dysfunction, which were inhibited by zinc as low as 10 μM but not by 2 mM NAC. These results suggest that chronic ethanol exposure induced in ER and mitochondrial zinc deficiency might activate intrinsic cell <span class="hlt">death</span> signaling pathway, which could not be effectively rescued by antioxidant treatment. PMID:25767260</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4531834','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4531834"><span>Cell <span class="hlt">Death</span> and Cell <span class="hlt">Death</span> Responses in Liver Disease: Mechanisms and Clinical Relevance</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Luedde, Tom; Kaplowitz, Neil; Schwabe, Robert F.</p> <p>2015-01-01</p> <p>Summary Hepatocellular <span class="hlt">death</span> is present in almost all types of human liver disease and is used as a sensitive parameter for the detection of acute and chronic liver disease of viral, toxic, metabolic, or autoimmune origin. Clinical data and animal models suggest that hepatocyte <span class="hlt">death</span> is the key trigger of liver disease progression, manifested by the subsequent development of inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma. Modes of hepatocellular <span class="hlt">death</span> differ substantially between liver diseases. Different modes of cell <span class="hlt">death</span> such as apoptosis, necrosis, and necroptosis trigger specific cell <span class="hlt">death</span> responses and promote progression of liver disease through distinct mechanisms. In this review, we first discuss molecular mechanisms by which different modes of cell <span class="hlt">death</span>, damage-associated molecular patterns, and specific cell <span class="hlt">death</span> responses contribute to the development of liver disease. We then review the clinical relevance of cell <span class="hlt">death</span>, focusing on biomarkers; the contribution of cell <span class="hlt">death</span> to drug-induced, viral, and fatty liver disease and liver cancer; and evidence for cell <span class="hlt">death</span> pathways as therapeutic targets. PMID:25046161</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=COT&pg=4&id=EJ322555','ERIC'); return false;" href="https://eric.ed.gov/?q=COT&pg=4&id=EJ322555"><span>Cot <span class="hlt">Deaths</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tyrrell, Shelagh</p> <p>1985-01-01</p> <p>Addresses the tragedy of crib <span class="hlt">deaths</span>, giving particular attention to causes, prevention, and medical research on Sudden Infant <span class="hlt">Death</span> Syndrome (SIDS). Gives anecdotal accounts of coping strategies used by parents and families of SIDS infants. (DT)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1060170','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1060170"><span>Insulin treated diabetes mellitus: causes of <span class="hlt">death</span> determined from record linkage of population based registers in Leicestershire, UK.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Raymond, N T; Langley, J D; Goyder, E; Botha, J L; Burden, A C; Hearnshaw, J R</p> <p>1995-01-01</p> <p>STUDY OBJECTIVE--Analyses of causes of mortality in people with diabetes using data form <span class="hlt">death</span> certificates mentioning diabetes provide unreliable estimates of mortality. Under-recording of diabetes as a cause on <span class="hlt">death</span> certificates has been widely reported, ranging from 15-60%. Using a population based register on people with diabetes and <span class="hlt">linking</span> data from another source is a viable alternative. Data from the Office of Population Censuses and Surveys (OPCS) are the most acceptable mortality data available for such an exercise, as direct comparison with other published mortality rates is then possible. DESIGN--A locally maintained population-based mortality register and all insulin-treated diabetes mellitus cases notified to the Leicestershire diabetes register (n = 4680) were <span class="hlt">linked</span> using record linkage software developed in-house (Lynx). This software has been extensively used in a maintenance and update cycle designed to maximise accuracy and minimise duplication and false registration on the diabetes register. <span class="hlt">Deaths</span> identified were initially coded locally to the International Classification of Diseases, 9th revision (ICD9), and later a linkage was performed to use official OPCS coding. Mortality data identified by the linkage was indirectly standardised using population data for Leicestershire for 1991. Standardised mortality ratios (SMR) were estimated, with 95% confidence intervals. Insulin dependent diabetes (IDDM) was defined as diabetes diagnosed before age 30 years with insulin therapy begun within one year of diagnosis. All other types were considered non-insulin dependent diabetes (NIDDM). Analyses were performed for the whole sample and then for the NIDDM subgroup. Results from these analyses were similar and therefore only whole group analyses are presented. MAIN RESULTS--A total of 370 <span class="hlt">deaths</span> were identified for the period of 1990-92 inclusive - 56% were in men and 44% in women, median age (range) 71 years (12-94). Approximately 90% of <span class="hlt">deaths</span> were</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24326219','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24326219"><span>Impact of social support on bereaved siblings' anxiety: a nationwide follow-up.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Eilertsen, Mary-Elizabeth Bradley; Eilegård, Alexandra; Steineck, Gunnar; Nyberg, Tommy; Kreicbergs, Ulrika</p> <p>2013-01-01</p> <p>To assess adolescent and young adult siblings' perception of social support prior to and following the loss of their brother or <span class="hlt">sister</span> to cancer, 2 to 9 years earlier, and their anxiety at follow-up. In 2009, 174 (73%) bereaved siblings (12-25 years) participated in a nationwide, long-term follow-up study in Sweden using an anonymous study-specific questionnaire. The Hospital Anxiety and Depression Scale was used to measure self-assessed anxiety. Siblings had a higher risk of anxiety if they perceived their need for social support was unsatisfied during their brother or <span class="hlt">sisters</span>' last month before <span class="hlt">death</span>, relative risk (RR) = 3.6 (95% confidence interval [CI] = 1.8-7.3); time after <span class="hlt">death</span>, RR = 2.9 (95% CI = 1.5-5.6); and at follow-up, RR = 3.8 (95% CI = 2.0-7.2). Furthermore, a higher risk for anxiety was shown for siblings if they did not perceive that their parents and neighbors cared for them after their brother or <span class="hlt">sisters</span>' <span class="hlt">death</span>, RR = 2.7 (95% CI = 1.3-5.5), RR = 5.4 (95% CI = 1.3-21.9), respectively. Bereaved siblings had a greater probability to report self-assessed anxiety if they perceived that their need for social support was not satisfied prior to and following <span class="hlt">death</span>. Information from both nurses and other health care professionals to families about the impact of social support may contribute to lessen the siblings' risk of anxiety.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014Natur.505..509D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014Natur.505..509D"><span>Cell <span class="hlt">death</span> by pyroptosis drives CD4 T-cell depletion in HIV-1 infection</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Doitsh, Gilad; Galloway, Nicole L. K.; Geng, Xin; Yang, Zhiyuan; Monroe, Kathryn M.; Zepeda, Orlando; Hunt, Peter W.; Hatano, Hiroyu; Sowinski, Stefanie; Muñoz-Arias, Isa; Greene, Warner C.</p> <p>2014-01-01</p> <p>The pathway causing CD4 T-cell <span class="hlt">death</span> in HIV-infected hosts remains poorly understood although apoptosis has been proposed as a key mechanism. We now show that caspase-3-mediated apoptosis accounts for the <span class="hlt">death</span> of only a small fraction of CD4 T cells corresponding to those that are both activated and productively infected. The remaining over 95% of quiescent lymphoid CD4 T cells die by caspase-1-mediated pyroptosis triggered by abortive viral infection. Pyroptosis corresponds to an intensely inflammatory form of programmed cell <span class="hlt">death</span> in which cytoplasmic contents and pro-inflammatory cytokines, including IL-1β, are released. This <span class="hlt">death</span> pathway thus <span class="hlt">links</span> the two signature events in HIV infection--CD4 T-cell depletion and chronic inflammation--and creates a pathogenic vicious cycle in which dying CD4 T cells release inflammatory signals that attract more cells to die. This cycle can be broken by caspase 1 inhibitors shown to be safe in humans, raising the possibility of a new class of `anti-AIDS' therapeutics targeting the host rather than the virus.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21051156','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21051156"><span>Thyroid gland and cerebella lesions: New risk factors for sudden cardiac <span class="hlt">death</span> in schizophrenia?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Scorza, Fulvio A; Cavalheiro, Esper A; de Albuquerque, Marly; de Albuquerque, Juliana; Cysneiros, Roberta M; Terra, Vera C; Arida, Ricardo M</p> <p>2011-02-01</p> <p>People with schizophrenia show a two to threefold increased risk to die prematurely than those without schizophrenia. Patients' life style, suicide, premature development of cardiovascular disease, high prevalence of metabolic syndrome and sudden cardiac <span class="hlt">death</span> are well-known causes of the excess mortality. The exact pathophysiological cause of sudden <span class="hlt">death</span> in schizophrenia is unknown, but it is likely that cardiac arrhythmia and respiratory abnormalities play potential role. Some antipsychotics may be associated with cardiovascular adverse events (e.g., QT interval prolongation) and lesions in specific brain regions, such as cerebella may be associated with respiratory abnormalities, suggesting that metabolic and brain dysfunction could lead to sudden cardiac <span class="hlt">death</span> in patients with schizophrenia. However, exact knowledge regarding the association of these findings and schizophrenia is lacking. As subclinical hyperthyroidism has been <span class="hlt">linked</span> with increased risk of cardiovascular disease and cerebella progressive atrophy has been observed in patients with schizophrenia, we propose in this paper that subclinical thyroid dysfunction and cerebella volume loss could be considered as new risk factor for sudden cardiac <span class="hlt">death</span> in schizophrenia. Copyright © 2010 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2667569','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2667569"><span>Frailty and type of <span class="hlt">death</span> among older adults in China: prospective cohort study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Warner, David F; Yi, Zeng</p> <p>2009-01-01</p> <p>Objective To examine the association between frailty and type of <span class="hlt">death</span> among the world’s largest oldest-old population in China. Design Prospective cohort study. Setting 2002 and 2005 waves of the Chinese longitudinal healthy longevity survey carried out in 22 provinces throughout China. Participants 13 717 older adults (aged ≥65). Main outcome measures Type of <span class="hlt">death</span>, categorised as being bedridden for fewer than 30 days with or without suffering and being bedridden for 30 or more days with or without suffering. Results Multinomial analyses showed that higher levels of frailty significantly increased the relative risk ratios of mortality for all types of <span class="hlt">death</span>. Of those with the highest levels of frailty, men were most likely to experience 30 or more bedridden days with suffering before <span class="hlt">death</span> (relative risk ratio 8.70, 95% confidence interval 6.31 to 12.00) and women 30 or more bedridden days with no suffering (11.53, 17.84 to 16.96). Regardless of frailty, centenarians and nonagenarians were most likely to experience fewer than 30 bedridden days with no suffering, whereas those aged 65-79 and 80-89 were more likely to experience fewer than 30 bedridden days with suffering. Adjusting for compositional differences had little impact on the <span class="hlt">link</span> between frailty and type of <span class="hlt">death</span> for both sexes and age groups. Conclusions The association between frailty and type of <span class="hlt">death</span> differs by sex and age. Health scholars and clinical practitioners should consider age and sex differences in frailty to develop more effective measures to reduce preventable suffering before <span class="hlt">death</span>. PMID:19359289</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PhyA..502....1R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PhyA..502....1R"><span>Exploration of the strength of family <span class="hlt">links</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Richmond, Peter; Roehner, Bertrand M.</p> <p>2018-07-01</p> <p>Ever since the studies of Louis-Adolphe Bertillon in the late 19th century it has been known that marital status and number of children markedly affect <span class="hlt">death</span> and suicide rates. This led in 1898 Emile Durkheim to conjecture a connection between social isolation (especially at family level) and suicide. However, further progress was long hampered by the limited statistical data available from <span class="hlt">death</span> certificates. Recently, it was shown by the present authors that disability data from census records can be used as a reliable substitute for mortality data. This opens a new route to investigations of family ties because census information goes much beyond the limited data reported on <span class="hlt">death</span> certificates. It is shown that the disability rate of adults decreases when they have more family <span class="hlt">links</span>. More precisely, the reduction of the parents' disability brought about by the presence of a child reveals that the strength of ties between parents and child is highest in the first year after birth and then weakens steadily as the child ages. It will also be seen that the strength of the bond between husband and wife is highest when they are of same age and decreases fairly steadily when the age gap increases.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=afterlife&pg=3&id=EJ381557','ERIC'); return false;" href="https://eric.ed.gov/?q=afterlife&pg=3&id=EJ381557"><span>Dreams of <span class="hlt">Death</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Barrett, Deirdre</p> <p>1989-01-01</p> <p>Examined frequency and characteristics of overt dreams of dying among healthy young adults. Dreams of dying were found to be rare but distinctive content category, representing overwhelmingly pleasant dreams. Over one-half of <span class="hlt">death</span> dreams involved lengthy afterlife sequence, remainder focused on process of <span class="hlt">death</span>. <span class="hlt">Death</span> dreams of these healthy…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27996932','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27996932"><span>Drugs Most Frequently Involved in Drug Overdose <span class="hlt">Deaths</span>: United States, 2010-2014.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Warner, Margaret; Trinidad, James P; Bastian, Brigham A; Minino, Arialdi M; Hedegaard, Holly</p> <p>2016-12-01</p> <p>Objectives-This report identifies the specific drugs most frequently involved in drug overdose <span class="hlt">deaths</span> in the United States from 2010 through 2014. Methods-The 2010-2014 National Vital Statistics System mortality files were <span class="hlt">linked</span> to electronic files containing literal text information from <span class="hlt">death</span> certificates. Drug overdose was defined using the International Classification of Diseases, Tenth Revision underlying cause-of-<span class="hlt">death</span> codes X40-X44 (unintentional), X60-X64 (suicide), X85 (homicide), and Y10-Y14 (undetermined intent). Among <span class="hlt">deaths</span> with an underlying cause of <span class="hlt">death</span> of drug overdose, the literal text in three fields of the <span class="hlt">death</span> certificate (i.e., the cause of <span class="hlt">death</span> from Part I, significant conditions contributing to <span class="hlt">death</span> from Part II, and a description of how the injury occurred from Box 43) were searched to identify drug mentions. Search term lists were developed using existing drug classification systems as well as from manual review of the literal text. The search term list was then used to identify the specific drugs involved in overdose <span class="hlt">deaths</span>. Descriptive statistics were reported for drug overdose <span class="hlt">deaths</span> involving the 10 most frequently mentioned drugs on <span class="hlt">death</span> certificates. Tables and figures presenting information on the specific drugs involved in <span class="hlt">deaths</span> are based on <span class="hlt">deaths</span> with mention of at least one specific drug on the <span class="hlt">death</span> certificate. Results-From 2010 through 2014, the number of drug overdose <span class="hlt">deaths</span> per year increased 23%, from 38,329 in 2010 to 47,055 in 2014. During this time period, the percentage of drug overdose <span class="hlt">deaths</span> involving at least one specific drug increased, from 67% in 2010 to 78% in 2014. Among drug overdose <span class="hlt">deaths</span> with at least one drug specified on the <span class="hlt">death</span> certificate, the 10 drugs most frequently involved in overdose <span class="hlt">deaths</span> included the following opioids: heroin, oxycodone, methadone, morphine, hydrocodone, and fentanyl; the following benzodiazepines: alprazolam and diazepam; and the following stimulants: cocaine and</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23955153','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23955153"><span>Pathogen blocks host <span class="hlt">death</span> receptor signalling by arginine GlcNAcylation of <span class="hlt">death</span> domains.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Li, Shan; Zhang, Li; Yao, Qing; Li, Lin; Dong, Na; Rong, Jie; Gao, Wenqing; Ding, Xiaojun; Sun, Liming; Chen, Xing; Chen, She; Shao, Feng</p> <p>2013-09-12</p> <p>The tumour necrosis factor (TNF) family is crucial for immune homeostasis, cell <span class="hlt">death</span> and inflammation. These cytokines are recognized by members of the TNF receptor (TNFR) family of <span class="hlt">death</span> receptors, including TNFR1 and TNFR2, and FAS and TNF-related apoptosis-inducing ligand (TRAIL) receptors. <span class="hlt">Death</span> receptor signalling requires <span class="hlt">death</span>-domain-mediated homotypic/heterotypic interactions between the receptor and its downstream adaptors, including TNFR1-associated <span class="hlt">death</span> domain protein (TRADD) and FAS-associated <span class="hlt">death</span> domain protein (FADD). Here we discover that <span class="hlt">death</span> domains in several proteins, including TRADD, FADD, RIPK1 and TNFR1, were directly inactivated by NleB, an enteropathogenic Escherichia coli (EPEC) type III secretion system effector known to inhibit host nuclear factor-κB (NF-κB) signalling. NleB contained an unprecedented N-acetylglucosamine (GlcNAc) transferase activity that specifically modified a conserved arginine in these <span class="hlt">death</span> domains (Arg 235 in the TRADD <span class="hlt">death</span> domain). NleB GlcNAcylation (the addition of GlcNAc onto a protein side chain) of <span class="hlt">death</span> domains blocked homotypic/heterotypic <span class="hlt">death</span> domain interactions and assembly of the oligomeric TNFR1 complex, thereby disrupting TNF signalling in EPEC-infected cells, including NF-κB signalling, apoptosis and necroptosis. Type-III-delivered NleB also blocked FAS ligand and TRAIL-induced cell <span class="hlt">death</span> by preventing formation of a FADD-mediated <span class="hlt">death</span>-inducing signalling complex (DISC). The arginine GlcNAc transferase activity of NleB was required for bacterial colonization in the mouse model of EPEC infection. The mechanism of action of NleB represents a new model by which bacteria counteract host defences, and also a previously unappreciated post-translational modification.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29493847','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29493847"><span>Comparison of cause of <span class="hlt">death</span> between anzdata and the australian national <span class="hlt">death</span> index.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sypek, Matthew P; Dansie, Kathryn B; Clayton, Phil; Webster, Angela C; McDonald, Stephen</p> <p>2018-03-01</p> <p>To understand the differences in how cause of <span class="hlt">death</span> for patients receiving renal replacement therapy in Australia is recorded in The Australian and New Zealand Dialysis and Transplant Registry (ANZDATA) compared to the National <span class="hlt">Death</span> Index (NDI). Data linkage was performed between ANZDATA and NDI for all <span class="hlt">deaths</span> in the period 1980-2013. Cause of <span class="hlt">death</span> was classified according to ICD-10 chapter. Overall and chapter specific agreement were assessed using the Kappa statistic. Descriptive analysis was used to explore differences where there was disagreement on primary cause of <span class="hlt">death</span>. The analysis cohort included 28,675 patients. Ninety five percent of ANZDATA reported <span class="hlt">deaths</span> fell within +/- 3 days of the date recorded by NDI. Circulatory <span class="hlt">death</span> was the most common cause of <span class="hlt">death</span> in both databases (ANZDATA 48%, NDI 32%). Overall agreement at ICD chapter level of primary cause was poor (36%, kappa 0.22). Agreement was best for malignancy (kappa 0.71). When there was disagreement on primary cause of <span class="hlt">death</span> these were most commonly coded as genitourinary (35%) and endocrine (25.0%) in NDI, and circulatory (39%) and withdrawal (24%) in ANZDATA. Sixty-nine percent of patients had a renal related cause documented as either primary or a contributing cause of <span class="hlt">death</span> in the NDI. There is poor agreement in primary cause of <span class="hlt">death</span> between ANZDATA and NDI which is in part explained by the absence of diabetes and renal failure as causes of <span class="hlt">death</span> in ANZDATA and the absence of 'withdrawal' in NDI. These differences should be appreciated when interpreting epidemiological data on cause of <span class="hlt">death</span> in the Australian end stage kidney disease population. This article is protected by copyright. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26212014','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26212014"><span>Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lee, C K; Yang, Y; Chen, C; Liu, J</p> <p>2016-04-14</p> <p>The transcription factor Miz1 negatively regulates TNF-induced JNK activation and cell <span class="hlt">death</span> by suppressing TRAF2 K63-polyubiquitination; upon TNF stimulation, the suppression is relieved by Mule/ARF-BP1-mediated Miz1 ubiquitination and subsequent degradation. It is not known how Mule is activated by TNF. Here we report that TNF activates Mule by inducing the dissociation of Mule from its inhibitor ARF. ARF binds to and thereby inhibits the E3 ligase activity of Mule in the steady state. TNF induces tyrosine phosphorylation of Mule, which subsequently dissociates from ARF and becomes activated. Inhibition of Mule phosphorylation by silencing of the Spleen Tyrosine Kinase (Syk) prevents its dissociation from ARF, thereby inhibiting Mule E3 ligase activity and TNF-induced JNK activation and cell <span class="hlt">death</span>. Our data provides a missing <span class="hlt">link</span> in TNF signaling pathway that leads to JNK activation and cell <span class="hlt">death</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16326764','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16326764"><span><span class="hlt">Deaths</span> from international terrorism compared with road crash <span class="hlt">deaths</span> in OECD countries.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wilson, N; Thomson, G</p> <p>2005-12-01</p> <p>To estimate the relative number of <span class="hlt">deaths</span> in member countries of the Organisation for Economic Co-operation and Development (OECD) from international terrorism and road crashes. Data on <span class="hlt">deaths</span> from international terrorism (US State Department database) were collated (1994-2003) and compared to the road injury <span class="hlt">deaths</span> (year 2000 and 2001 data) from the OECD International Road Transport Accident Database. In the 29 OECD countries for which comparable data were available, the annual average <span class="hlt">death</span> rate from road injury was approximately 390 times that from international terrorism. The ratio of annual road to international terrorism <span class="hlt">deaths</span> (averaged over 10 years) was lowest for the United States at 142 times. In 2001, road crash <span class="hlt">deaths</span> in the US were equal to those from a September 11 attack every 26 days. There is a large difference in the magnitude of these two causes of <span class="hlt">deaths</span> from injury. Policy makers need to be aware of this when allocating resources to preventing these two avoidable causes of mortality.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19181691','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19181691"><span>Sibling <span class="hlt">death</span> and <span class="hlt">death</span> fear in relation to depressive symptomatology in older adults.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cicirelli, Victor G</p> <p>2009-01-01</p> <p>Previously overlooked factors in elders' depressive symptomatology were examined, including <span class="hlt">death</span> fear, sibling <span class="hlt">death</span>, and sibling closeness. Participants were 150 elders (61 men, 89 women) aged 65-97 years with at least one sibling. Measures were proportion of deceased siblings, sibling closeness, the <span class="hlt">Death</span> Fear Subscale of the <span class="hlt">Death</span> Attitude Profile-Revised, and the Center for Epidemiological Studies-Depression scale (20-item adult form). Age and education were exogenous variables in a structural equation model. <span class="hlt">Death</span> fear, sibling closeness, and proportion of dead siblings were directly related to depression, with path coefficients of .42, -.24, and .13, respectively. Proportion of dead siblings had indirect effects on depression, as did age and education. Depressive symptomatology in old age is influenced by <span class="hlt">death</span> fear related to sibling <span class="hlt">death</span> as well as by poor relationships with them; it must be understood within a situational context including <span class="hlt">death</span> fear and sibling relationships.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=339317','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=339317"><span>Genome sequence and physiological analysis of Yamadazyma laniorum f.a. sp. nov. and a reevaluation of the apocryphal xylose fermentation of its <span class="hlt">sister</span> species, Candida tenuis</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>Xylose fermentation is a rare trait that is immensely important to the cellulosic biofuel industry, and Candida tenuis is one of the few yeasts that has been reported with this trait. Here we report the isolation of two strains representing a candidate <span class="hlt">sister</span> species to C. tenuis. Integrated analysi...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2562863','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2562863"><span>Predicting Impending <span class="hlt">Death</span>: Inconsistency in Speed is a Selective and Early Marker</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>MacDonald, Stuart W.S.; Hultsch, David F.; Dixon, Roger A.</p> <p>2008-01-01</p> <p>Among older adults, deficits in both level and variability of speeded performance are <span class="hlt">linked</span> to neurological impairment. This study examined whether and when speed (rate), speed (inconsistency), and traditional accuracy-based markers of cognitive performance foreshadow terminal decline and impending <span class="hlt">death</span>. Victoria Longitudinal Study data spanning 12 years (5 waves) of measurement were assembled for 707 adults aged 59 to 95 years. Whereas 442 survivors completed all waves and relevant measures, 265 decedents participated on at least one occasion and subsequently died. Four main results were observed. First, Cox regressions evaluating the three cognitive predictors of mortality replicated previous results for cognitive accuracy predictors. Second, level (rate) of speeded performance predicted survival independent of demographic indicators, cardiovascular health, and cognitive performance level. Third, inconsistency in speed predicted survival independent of all influences combined. Fourth, follow-up random-effects models revealed increases in inconsistency in speed per year closer to <span class="hlt">death</span>, with advancing age further moderating the accelerated growth. Hierarchical prediction patterns support the view that inconsistency in speed is an early behavioral marker of neurological dysfunction associated with impending <span class="hlt">death</span>. PMID:18808249</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/14738547','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/14738547"><span>Racial differences in leading causes of infant <span class="hlt">death</span> in the United States.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Muhuri, Pradip K; MacDorman, Marian F; Ezzati-Rice, Trena M</p> <p>2004-01-01</p> <p>We used <span class="hlt">linked</span> birth/infant <span class="hlt">death</span> records of over 23 million singletons belonging to six birth cohorts (1989-91 and 1995-97) and examined changes in race differentials in the overall and cause-specific infant mortality risks across time in the United States. Results show that infant mortality declined for all races during the time period, with disproportionately greater declines among non-Hispanic American Indians (AIs). Among the leading causes of infant <span class="hlt">death</span>, declines in mortality from sudden infant <span class="hlt">death</span> syndrome (SIDS), respiratory distress syndrome (RDS) and congenital anomalies contributed the most to the overall decline in infant mortality in the 1995-97 cohorts, compared with the 1989-91 cohorts. Disproportionately greater reductions in mortality resulting from SIDS and congenital anomalies led to more rapid mortality declines among non-Hispanic AIs than for other races. There are disturbing findings that infants of almost every race experienced increases in mortality from newborn affected by maternal complications of pregnancy (maternal complications) and that none of the race groups experienced a significant decline in mortality from disorders resulting from short gestation/low birthweight.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29362479','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29362479"><span>Molecular mechanisms of cell <span class="hlt">death</span>: recommendations of the Nomenclature Committee on Cell <span class="hlt">Death</span> 2018.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A; Abrams, John M; Adam, Dieter; Agostinis, Patrizia; Alnemri, Emad S; Altucci, Lucia; Amelio, Ivano; Andrews, David W; Annicchiarico-Petruzzelli, Margherita; Antonov, Alexey V; Arama, Eli; Baehrecke, Eric H; Barlev, Nickolai A; Bazan, Nicolas G; Bernassola, Francesca; Bertrand, Mathieu J M; Bianchi, Katiuscia; Blagosklonny, Mikhail V; Blomgren, Klas; Borner, Christoph; Boya, Patricia; Brenner, Catherine; Campanella, Michelangelo; Candi, Eleonora; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K-M; Chandel, Navdeep S; Cheng, Emily H; Chipuk, Jerry E; Cidlowski, John A; Ciechanover, Aaron; Cohen, Gerald M; Conrad, Marcus; Cubillos-Ruiz, Juan R; Czabotar, Peter E; D'Angiolella, Vincenzo; Dawson, Ted M; Dawson, Valina L; De Laurenzi, Vincenzo; De Maria, Ruggero; Debatin, Klaus-Michael; DeBerardinis, Ralph J; Deshmukh, Mohanish; Di Daniele, Nicola; Di Virgilio, Francesco; Dixit, Vishva M; Dixon, Scott J; Duckett, Colin S; Dynlacht, Brian D; El-Deiry, Wafik S; Elrod, John W; Fimia, Gian Maria; Fulda, Simone; García-Sáez, Ana J; Garg, Abhishek D; Garrido, Carmen; Gavathiotis, Evripidis; Golstein, Pierre; Gottlieb, Eyal; Green, Douglas R; Greene, Lloyd A; Gronemeyer, Hinrich; Gross, Atan; Hajnoczky, Gyorgy; Hardwick, J Marie; Harris, Isaac S; Hengartner, Michael O; Hetz, Claudio; Ichijo, Hidenori; Jäättelä, Marja; Joseph, Bertrand; Jost, Philipp J; Juin, Philippe P; Kaiser, William J; Karin, Michael; Kaufmann, Thomas; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N; Klionsky, Daniel J; Knight, Richard A; Kumar, Sharad; Lee, Sam W; Lemasters, John J; Levine, Beth; Linkermann, Andreas; Lipton, Stuart A; Lockshin, Richard A; López-Otín, Carlos; Lowe, Scott W; Luedde, Tom; Lugli, Enrico; MacFarlane, Marion; Madeo, Frank; Malewicz, Michal; Malorni, Walter; Manic, Gwenola; Marine, Jean-Christophe; Martin, Seamus J; Martinou, Jean-Claude; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Sonia; Miao, Edward A; Molkentin, Jeffery D; Moll, Ute M; Muñoz-Pinedo, Cristina; Nagata, Shigekazu; Nuñez, Gabriel; Oberst, Andrew; Oren, Moshe; Overholtzer, Michael; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M; Pereira, David M; Pervaiz, Shazib; Peter, Marcus E; Piacentini, Mauro; Pinton, Paolo; Prehn, Jochen H M; Puthalakath, Hamsa; Rabinovich, Gabriel A; Rehm, Markus; Rizzuto, Rosario; Rodrigues, Cecilia M P; Rubinsztein, David C; Rudel, Thomas; Ryan, Kevin M; Sayan, Emre; Scorrano, Luca; Shao, Feng; Shi, Yufang; Silke, John; Simon, Hans-Uwe; Sistigu, Antonella; Stockwell, Brent R; Strasser, Andreas; Szabadkai, Gyorgy; Tait, Stephen W G; Tang, Daolin; Tavernarakis, Nektarios; Thorburn, Andrew; Tsujimoto, Yoshihide; Turk, Boris; Vanden Berghe, Tom; Vandenabeele, Peter; Vander Heiden, Matthew G; Villunger, Andreas; Virgin, Herbert W; Vousden, Karen H; Vucic, Domagoj; Wagner, Erwin F; Walczak, Henning; Wallach, David; Wang, Ying; Wells, James A; Wood, Will; Yuan, Junying; Zakeri, Zahra; Zhivotovsky, Boris; Zitvogel, Laurence; Melino, Gerry; Kroemer, Guido</p> <p>2018-03-01</p> <p>Over the past decade, the Nomenclature Committee on Cell <span class="hlt">Death</span> (NCCD) has formulated guidelines for the definition and interpretation of cell <span class="hlt">death</span> from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell <span class="hlt">death</span> pathways are unveiled, we propose an updated classification of cell <span class="hlt">death</span> subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell <span class="hlt">death</span>, NETotic cell <span class="hlt">death</span>, lysosome-dependent cell <span class="hlt">death</span>, autophagy-dependent cell <span class="hlt">death</span>, immunogenic cell <span class="hlt">death</span>, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell <span class="hlt">death</span> in support of the continued development of the field.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21555324','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21555324"><span>Fluid status monitoring with a wireless network to reduce cardiovascular-related hospitalizations and mortality in heart failure: rationale and design of the Opti<span class="hlt">Link</span> HF Study (Optimization of Heart Failure Management using OptiVol Fluid Status Monitoring and Care<span class="hlt">Link</span>).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Brachmann, Johannes; Böhm, Michael; Rybak, Karin; Klein, Gunnar; Butter, Christian; Klemm, Hanno; Schomburg, Rolf; Siebermair, Johannes; Israel, Carsten; Sinha, Anil-Martin; Drexler, Helmut</p> <p>2011-07-01</p> <p>The Optimization of Heart Failure Management using OptiVol Fluid Status Monitoring and Care<span class="hlt">Link</span> (Opti<span class="hlt">Link</span> HF) study is designed to investigate whether OptiVol fluid status monitoring with an automatically generated wireless CareAlert notification via the Care<span class="hlt">Link</span> Network can reduce all-cause <span class="hlt">death</span> and cardiovascular hospitalizations in an HF population, compared with standard clinical assessment. Methods Patients with newly implanted or replacement cardioverter-defibrillator devices with or without cardiac resynchronization therapy, who have chronic HF in New York Heart Association class II or III and a left ventricular ejection fraction ≤35% will be eligible to participate. Following device implantation, patients are randomized to either OptiVol fluid status monitoring through CareAlert notification or regular care (Opti<span class="hlt">Link</span> 'on' vs. 'off'). The primary endpoint is a composite of all-cause <span class="hlt">death</span> or cardiovascular hospitalization. It is estimated that 1000 patients will be required to demonstrate superiority of the intervention group to reduce the primary outcome by 30% with 80% power. The Opti<span class="hlt">Link</span> HF study is designed to investigate whether early detection of congestion reduces mortality and cardiovascular hospitalization in patients with chronic HF. The study is expected to close recruitment in September 2012 and to report first results in May 2014.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23537399','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23537399"><span>Cell <span class="hlt">death</span> proteomics database: consolidating proteomics data on cell <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Arntzen, Magnus Ø; Bull, Vibeke H; Thiede, Bernd</p> <p>2013-05-03</p> <p>Programmed cell <span class="hlt">death</span> is a ubiquitous process of utmost importance for the development and maintenance of multicellular organisms. More than 10 different types of programmed cell <span class="hlt">death</span> forms have been discovered. Several proteomics analyses have been performed to gain insight in proteins involved in the different forms of programmed cell <span class="hlt">death</span>. To consolidate these studies, we have developed the cell <span class="hlt">death</span> proteomics (CDP) database, which comprehends data from apoptosis, autophagy, cytotoxic granule-mediated cell <span class="hlt">death</span>, excitotoxicity, mitotic catastrophe, paraptosis, pyroptosis, and Wallerian degeneration. The CDP database is available as a web-based database to compare protein identifications and quantitative information across different experimental setups. The proteomics data of 73 publications were integrated and unified with protein annotations from UniProt-KB and gene ontology (GO). Currently, more than 6,500 records of more than 3,700 proteins are included in the CDP. Comparing apoptosis and autophagy using overrepresentation analysis of GO terms, the majority of enriched processes were found in both, but also some clear differences were perceived. Furthermore, the analysis revealed differences and similarities of the proteome between autophagosomal and overall autophagy. The CDP database represents a useful tool to consolidate data from proteome analyses of programmed cell <span class="hlt">death</span> and is available at http://celldeathproteomics.uio.no.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20978809','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20978809"><span>Megasporogenesis and programmed cell <span class="hlt">death</span> in Tillandsia (Bromeliaceae).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Papini, Alessio; Mosti, Stefano; Milocani, Eva; Tani, Gabriele; Di Falco, Pietro; Brighigna, Luigi</p> <p>2011-10-01</p> <p>The degeneration of three of four meiotic products is a very common process in the female gender of oogamous eukaryotes. In Tillandsia (and many other angiosperms), the surviving megaspore has a callose-free wall in chalazal position while the other three megaspores are completely embedded in callose. Therefore, nutrients and signals can reach more easily the functional megaspore from the nucellus through the chalazal pole with respect to the other megaspores. The abortion of three of four megaspores was already recognized as the result of a programmed cell <span class="hlt">death</span> (PCD) process. We investigated the process to understand the modality of this specific type of PCD and its relationship to the asymmetric callose deposition around the tetrad. The decision on which of the four megaspores will be the supernumerary megaspores in angiosperms, and hence destined to undergo programmed cell <span class="hlt">death</span>, appears to be <span class="hlt">linked</span> to the callose layer deposition around the tetrad. During supernumerary megaspores degeneration, events leading to the deletion of the cells do not appear to belong to a single type of cell <span class="hlt">death</span>. The first morphological signs are typical of autophagy, including the formation of autophagosomes. The TUNEL positivity and a change in morphology of mitochondria and chloroplasts indicate the passage to an apoptotic-like PCD phase, while the cellular remnants undergo a final process resembling at least partially (ER swelling) necrotic morphological syndromes, eventually leading to a mainly lipidic cell corpse still separated from the functional megaspore by a callose layer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26627487','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26627487"><span>An Overview of <span class="hlt">Links</span> Between Obesity and Mental Health.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Avila, Christian; Holloway, Alison C; Hahn, Margaret K; Morrison, Katherine M; Restivo, Maria; Anglin, Rebecca; Taylor, Valerie H</p> <p>2015-09-01</p> <p>The American Medical Association recently recognized obesity as both an illness and a leading cause of preventable <span class="hlt">death</span> and chronic disease. This association is not only <span class="hlt">linked</span> to physical health outcomes, however, as obesity has also been extensively associated with mental illness as well. Both obesity and severe mental illness decrease quality of life and are associated with an increase in disability, morbidity, and mortality, and when they occur together, these adverse health outcomes are magnified. Despite educational campaigns, increased awareness, and improved treatment options, the high prevalence of mental illness and comorbid obesity remains a serious problem. This review examines this overlap, highlighting clinical and biological factors that have been <span class="hlt">linked</span> to this association in order to improve our understanding and help elucidate potential therapeutic avenues.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24785982','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24785982"><span>Potentially preventable <span class="hlt">deaths</span> from the five leading causes of <span class="hlt">death</span>--United States, 2008-2010.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yoon, Paula W; Bastian, Brigham; Anderson, Robert N; Collins, Janet L; Jaffe, Harold W</p> <p>2014-05-02</p> <p>In 2010, the top five causes of <span class="hlt">death</span> in the United States were 1) diseases of the heart, 2) cancer, 3) chronic lower respiratory diseases, 4) cerebrovascular diseases (stroke), and 5) unintentional injuries. The rates of <span class="hlt">death</span> from each cause vary greatly across the 50 states and the District of Columbia (2). An understanding of state differences in <span class="hlt">death</span> rates for the leading causes might help state health officials establish disease prevention goals, priorities, and strategies. States with lower <span class="hlt">death</span> rates can be used as benchmarks for setting achievable goals and calculating the number of <span class="hlt">deaths</span> that might be prevented in states with higher rates. To determine the number of premature annual <span class="hlt">deaths</span> for the five leading causes of <span class="hlt">death</span> that potentially could be prevented ("potentially preventable <span class="hlt">deaths</span>"), CDC analyzed National Vital Statistics System mortality data from 2008-2010. The number of annual potentially preventable <span class="hlt">deaths</span> per state before age 80 years was determined by comparing the number of expected <span class="hlt">deaths</span> (based on average <span class="hlt">death</span> rates for the three states with the lowest rates for each cause) with the number of observed <span class="hlt">deaths</span>. The results of this analysis indicate that, when considered separately, 91,757 <span class="hlt">deaths</span> from diseases of the heart, 84,443 from cancer, 28,831 from chronic lower respiratory diseases, 16,973 from cerebrovascular diseases (stroke), and 36,836 from unintentional injuries potentially could be prevented each year. In addition, states in the Southeast had the highest number of potentially preventable <span class="hlt">deaths</span> for each of the five leading causes. The findings provide disease-specific targets that states can use to measure their progress in preventing the leading causes of <span class="hlt">deaths</span> in their populations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16076860','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16076860"><span>Season of <span class="hlt">death</span> and birth predict patterns of mortality in Burkina Faso.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kynast-Wolf, Gisela; Hammer, Gaël P; Müller, Olaf; Kouyaté, Bocar; Becher, Heiko</p> <p>2006-04-01</p> <p>Mortality in developing countries has multiple causes. Some of these causes are <span class="hlt">linked</span> to climatic conditions that differ over the year. Data on season-specific mortality are sparse. We analysed longitudinal data from a population of approximately 35,000 individuals in Burkina Faso. During the observation period 1993-2001, a total number of 4,098 <span class="hlt">deaths</span> were recorded. The effect of season on mortality was investigated separately by age group as (i) date of <span class="hlt">death</span> and (ii) date of birth. For (i), age-specific <span class="hlt">death</span> rates by month of <span class="hlt">death</span> were calculated. The relative effect of each month was assessed using the floating relative risk method and modelled continuously. For (ii), age-specific <span class="hlt">death</span> rates by month of birth were calculated and the mean date of birth among <span class="hlt">deaths</span> and survivors was compared. Overall mortality was found to be consistently higher during the dry season (November to May). The pattern was seen in all age groups except in infants where a peak was seen around the end of the rainy season. In infants we found a strong association between high mortality and being born during the time period September to February. No effect was seen for the other age groups. The observed excess mortality in young children at or around the end of the rainy season can be explained by the effects of infectious diseases and, in particular, malaria during this time period. In contrast, the excess mortality seen in older children and adults during the early dry season remains largely unexplained although specific infectious diseases such as meningitis and pneumonia are possible main causes. The association between high infant mortality and being born at around the end of the rainy season is probably explained by most of the malaria <span class="hlt">deaths</span> in areas of high transmission intensity occurring in the second half of infancy.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26572932','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26572932"><span>Maternal obesity and gestational weight gain are risk factors for infant <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bodnar, Lisa M; Siminerio, Lara L; Himes, Katherine P; Hutcheon, Jennifer A; Lash, Timothy L; Parisi, Sara M; Abrams, Barbara</p> <p>2016-02-01</p> <p>Assessment of the joint and independent relationships of gestational weight gain and prepregnancy body mass index (BMI) on risk of infant mortality was performed. This study used Pennsylvania <span class="hlt">linked</span> birth-infant <span class="hlt">death</span> records (2003-2011) from infants without anomalies born to mothers with prepregnancy BMI categorized as underweight (n = 58,973), normal weight (n = 610,118), overweight (n = 296,630), grade 1 obesity (n = 147,608), grade 2 obesity (n = 71,740), and grade 3 obesity (n = 47,277). Multivariable logistic regression models stratified by BMI category were used to estimate dose-response associations between z scores of gestational weight gain and infant <span class="hlt">death</span> after confounder adjustment. Infant mortality risk was lowest among normal-weight women and increased with rising BMI category. For all BMI groups except for grade 3 obesity, there were U-shaped associations between gestational weight gain and risk of infant <span class="hlt">death</span>. Weight loss and very low weight gain among women with grades 1 and 2 obesity were associated with high risks of infant mortality. However, even when gestational weight gain in women with obesity was optimized, the predicted risk of infant <span class="hlt">death</span> remained higher than that of normal-weight women. Interventions aimed at substantially reducing preconception weight among women with obesity and avoiding very low or very high gestational weight gain may reduce risk of infant <span class="hlt">death</span>. © 2015 The Obesity Society.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26250050','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26250050"><span>First Miocene rodent from Lebanon provides the 'missing <span class="hlt">link</span>' between Asian and African gundis (Rodentia: Ctenodactylidae).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>López-Antoñanzas, Raquel; Knoll, Fabien; Maksoud, Sibelle; Azar, Dany</p> <p>2015-08-07</p> <p>Ctenodactylinae (gundis) is a clade of rodents that experienced, in Miocene time, their greatest diversification and widest distribution. They expanded from the Far East, their area of origin, to Africa, which they entered from what would become the Arabian Peninsula. Questions concerning the origin of African Ctenodactylinae persist essentially because of a poor fossil record from the Miocene of Afro-Arabia. However, recent excavations in the Late Miocene of Lebanon have yielded a key taxon for our understanding of these issues. Proafricanomys libanensis nov. gen. nov. sp. shares a variety of dental characters with both the most primitive and derived members of the subfamily. A cladistic analysis demonstrates that this species is the <span class="hlt">sister</span> taxon to a clade encompassing all but one of the African ctenodactylines, plus a southern European species of obvious African extraction. As such, Proafricanomys provides the 'missing <span class="hlt">link</span>' between the Asian and African gundis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4528195','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4528195"><span>First Miocene rodent from Lebanon provides the 'missing <span class="hlt">link</span>' between Asian and African gundis (Rodentia: Ctenodactylidae)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>López-Antoñanzas, Raquel; Knoll, Fabien; Maksoud, Sibelle; Azar, Dany</p> <p>2015-01-01</p> <p>Ctenodactylinae (gundis) is a clade of rodents that experienced, in Miocene time, their greatest diversification and widest distribution. They expanded from the Far East, their area of origin, to Africa, which they entered from what would become the Arabian Peninsula. Questions concerning the origin of African Ctenodactylinae persist essentially because of a poor fossil record from the Miocene of Afro-Arabia. However, recent excavations in the Late Miocene of Lebanon have yielded a key taxon for our understanding of these issues. Proafricanomys libanensis nov. gen. nov. sp. shares a variety of dental characters with both the most primitive and derived members of the subfamily. A cladistic analysis demonstrates that this species is the <span class="hlt">sister</span> taxon to a clade encompassing all but one of the African ctenodactylines, plus a southern European species of obvious African extraction. As such, Proafricanomys provides the 'missing <span class="hlt">link</span>' between the Asian and African gundis. PMID:26250050</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11452510','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11452510"><span>[Detection of underlying causes of <span class="hlt">death</span> among the deceased of Yusho patients by linkage to the national vital statistics data].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kaneko, S; Yoshimura, T; Ikeda, M; Nishisaka, K</p> <p>2001-05-01</p> <p>As of January 31, 1996, 292 <span class="hlt">deaths</span> among registered patients of Yusho were identified by three follow-up studies conducted in 1986, 1990, and 1996. In this study, we attempted to identify underlying causes of <span class="hlt">death</span> by linkage of the registered data to the National Vital Statistics Data provided by the Management and Coordination Agency of Japan, which included 15 million <span class="hlt">deaths</span> between 1978 and 1996. The two datasets were <span class="hlt">linked</span> by matching for six variables; birth year/month/day, <span class="hlt">death</span> year/month, and sex, along with a variable of <span class="hlt">death</span> day or <span class="hlt">death</span> place, or both. The matched cases were 203 among 235 <span class="hlt">deaths</span> between 1978 and 1996 (matching rate was 86%). Among the 203 <span class="hlt">deaths</span>, 58 underlying causes of <span class="hlt">death</span> were newly identified, 146 causes of <span class="hlt">death</span> were already grasped by the follow-up studies, and 31 <span class="hlt">deaths</span> did not have matching pair in the National Vital Statistics data. Among the 146 <span class="hlt">deaths</span>, 110 causes of <span class="hlt">death</span> were concordant with each other, however, 35 causes of <span class="hlt">death</span> were completely discord. The reason of the discordance and the unmatched <span class="hlt">deaths</span> might be due to difference in information of the matching variables in the two datasets. In order to conduct an efficient follow-up study of Yusho patients, identification of underlying causes of <span class="hlt">death</span> by linkage to the National Vital Statistics Date is evitable. For that, we need to substitute basic information in the Yusho database to those compatible to the National civil registration system.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28521050','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28521050"><span>Sudden Unexpected <span class="hlt">Death</span> During Sleep in Familial Dysautonomia: A Case-Control Study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Palma, Jose-Alberto; Norcliffe-Kaufmann, Lucy; Perez, Miguel A; Spalink, Christy L; Kaufmann, Horacio</p> <p>2017-08-01</p> <p>Sudden unexpected <span class="hlt">death</span> during sleep (SUDS) is the most common cause of <span class="hlt">death</span> in patients with familial dysautonomia (FD), an autosomal recessive disease characterized by sensory and autonomic dysfunction. It remains unknown what causes SUDS in these patients and who is at highest risk. We tested the hypothesis that SUDS in FD is <span class="hlt">linked</span> to sleep-disordered breathing. We retrospectively identified patients with FD who died suddenly and unexpectedly during sleep and had undergone polysomnography within the 18-month period before <span class="hlt">death</span>. For each case, we sampled one age-matched surviving subject with FD that had also undergone polysomnography within the 18-month period before study. Data on polysomnography, EKG, ambulatory blood pressure monitoring, arterial blood gases, blood count, and metabolic panel were analyzed. Thirty-two deceased cases and 31 surviving controls were included. Autopsy was available in six cases. Compared with controls, participants with SUDS were more likely to be receiving treatment with fludrocortisone (odds ratio [OR]; 95% confidence interval) (OR 29.7; 4.1-213.4), have untreated obstructive sleep apnea (OR 17.4; 1.5-193), and plasma potassium levels <4 mEq/L (OR 19.5; 2.36-161) but less likely to use noninvasive ventilation at night (OR 0.19; 0.06-0.61). Initiation of noninvasive ventilation when required and discontinuation of fludrocortisone treatment may reduce the high incidence rate of SUDS in patients with FD. Our findings contribute to the understanding of the <span class="hlt">link</span> between autonomic, cardiovascular, and respiratory risk factors in SUDS. © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_25 --> <div class="footer-extlink text-muted" style="margin-bottom:1rem; text-align:center;">Some links on this page may take you to non-federal websites. Their policies may differ from this site.</div> </div><!-- container --> <footer><a id="backToTop" href="#top"> </a><nav><a id="backToTop" href="#top"> </a><ul class="links"><a id="backToTop" href="#top"> </a><li><a id="backToTop" href="#top"></a><a href="/sitemap.html">Site Map</a></li> <li><a href="/members/index.html">Members Only</a></li> <li><a href="/website-policies.html">Website Policies</a></li> <li><a href="https://doe.responsibledisclosure.com/hc/en-us" target="_blank">Vulnerability Disclosure Program</a></li> <li><a href="/contact.html">Contact Us</a></li> </ul> <div class="small">Science.gov is maintained by the U.S. Department of Energy's <a href="https://www.osti.gov/" target="_blank">Office of Scientific and Technical Information</a>, in partnership with <a href="https://www.cendi.gov/" target="_blank">CENDI</a>.</div> </nav> </footer> <script type="text/javascript"><!-- // var lastDiv = ""; function showDiv(divName) { // hide last div if (lastDiv) { document.getElementById(lastDiv).className = "hiddenDiv"; } //if value of the box is not nothing and an object with that name exists, then change the class if (divName && document.getElementById(divName)) { document.getElementById(divName).className = "visibleDiv"; lastDiv = divName; } } //--> </script> <script> /** * Function that tracks a click on an outbound link in Google Analytics. * This function takes a valid URL string as an argument, and uses that URL string * as the event label. */ var trackOutboundLink = function(url,collectionCode) { try { h = window.open(url); setTimeout(function() { ga('send', 'event', 'topic-page-click-through', collectionCode, url); }, 1000); } catch(err){} }; </script> <!-- Google Analytics --> <script> (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','//www.google-analytics.com/analytics.js','ga'); ga('create', 'UA-1122789-34', 'auto'); ga('send', 'pageview'); </script> <!-- End Google Analytics --> <script> showDiv('page_1') </script> </body> </html>