FPGA-Based Front-End Electronics for Positron Emission Tomography

PubMed Central

Haselman, Michael; DeWitt, Don; McDougald, Wendy; Lewellen, Thomas K.; Miyaoka, Robert; Hauck, Scott

2010-01-01

Modern Field Programmable Gate Arrays (FPGAs) are capable of performing complex discrete signal processing algorithms with clock rates above 100MHz. This combined with FPGA’s low expense, ease of use, and selected dedicated hardware make them an ideal technology for a data acquisition system for positron emission tomography (PET) scanners. Our laboratory is producing a high-resolution, small-animal PET scanner that utilizes FPGAs as the core of the front-end electronics. For this next generation scanner, functions that are typically performed in dedicated circuits, or offline, are being migrated to the FPGA. This will not only simplify the electronics, but the features of modern FPGAs can be utilizes to add significant signal processing power to produce higher resolution images. In this paper two such processes, sub-clock rate pulse timing and event localization, will be discussed in detail. We show that timing performed in the FPGA can achieve a resolution that is suitable for small-animal scanners, and will outperform the analog version given a low enough sampling period for the ADC. We will also show that the position of events in the scanner can be determined in real time using a statistical positioning based algorithm. PMID:21961085

The integration of emotional and symbolic components in multimodal communication

PubMed Central

Mehu, Marc

2015-01-01

Human multimodal communication can be said to serve two main purposes: information transfer and social influence. In this paper, I argue that different components of multimodal signals play different roles in the processes of information transfer and social influence. Although the symbolic components of communication (e.g., verbal and denotative signals) are well suited to transfer conceptual information, emotional components (e.g., non-verbal signals that are difficult to manipulate voluntarily) likely take a function that is closer to social influence. I suggest that emotion should be considered a property of communicative signals, rather than an entity that is transferred as content by non-verbal signals. In this view, the effect of emotional processes on communication serve to change the quality of social signals to make them more efficient at producing responses in perceivers, whereas symbolic components increase the signals’ efficiency at interacting with the cognitive processes dedicated to the assessment of relevance. The interaction between symbolic and emotional components will be discussed in relation to the need for perceivers to evaluate the reliability of multimodal signals. PMID:26217280

Multi-purpose CMOS sensor interface for low-power applications

NASA Astrophysics Data System (ADS)

Wouters, P.; de Cooman, M.; Puers, R.

1994-08-01

A dedicated low-power CMOS transponder microchip is presented as part of a novel telemetry implant for biomedical applications. This mixed analog-digital circuit contains an identification code and collects information on physiological parameters, i.e., body temperature and physical activity, and on the status of the battery. To minimize the amount of data to be transmitted, a dedicated signal processing algorithm is embedded within its circuitry. All telemetry functions (encoding, modulation, generation of the carrier) are implemented on the integrated circuit. Emphasis is on a high degree of flexibility towards sensor inputs and internal data management, extreme miniaturization, and low-power consumption to allow a long implantation lifetime.

Behavioural and physiological limits to vision in mammals

PubMed Central

Field, Greg D.

2017-01-01

Human vision is exquisitely sensitive—a dark-adapted observer is capable of reliably detecting the absorption of a few quanta of light. Such sensitivity requires that the sensory receptors of the retina, rod photoreceptors, generate a reliable signal when single photons are absorbed. In addition, the retina must be able to extract this information and relay it to higher visual centres under conditions where very few rods signal single-photon responses while the majority generate only noise. Critical to signal transmission are mechanistic optimizations within rods and their dedicated retinal circuits that enhance the discriminability of single-photon responses by mitigating photoreceptor and synaptic noise. We describe behavioural experiments over the past century that have led to the appreciation of high sensitivity near absolute visual threshold. We further consider mechanisms within rod photoreceptors and dedicated rod circuits that act to extract single-photon responses from cellular noise. We highlight how these studies have shaped our understanding of brain function and point out several unresolved questions in the processing of light near the visual threshold. This article is part of the themed issue ‘Vision in dim light’. PMID:28193817

10 CFR 21.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... dedication process. (2) When applied to standard design certifications under subpart C of part 52 of this... CFR part 50, dedicating entity means the organization that performs the dedication process. Dedication... auditable records of the dedication process. Dedication. (1) When applied to nuclear power plants licensed...

10 CFR 21.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... dedication process. (2) When applied to standard design certifications under subpart C of part 52 of this... CFR part 50, dedicating entity means the organization that performs the dedication process. Dedication... auditable records of the dedication process. Dedication. (1) When applied to nuclear power plants licensed...

10 CFR 21.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... dedication process. (2) When applied to standard design certifications under subpart C of part 52 of this... CFR part 50, dedicating entity means the organization that performs the dedication process. Dedication... auditable records of the dedication process. Dedication. (1) When applied to nuclear power plants licensed...

10 CFR 21.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... dedication process. (2) When applied to standard design certifications under subpart C of part 52 of this... CFR part 50, dedicating entity means the organization that performs the dedication process. Dedication... auditable records of the dedication process. Dedication. (1) When applied to nuclear power plants licensed...

10 CFR 21.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... dedication process. (2) When applied to standard design certifications under subpart C of part 52 of this... CFR part 50, dedicating entity means the organization that performs the dedication process. Dedication... auditable records of the dedication process. Dedication. (1) When applied to nuclear power plants licensed...

Cyclic Dinucleotides in the Scope of the Mammalian Immune System.

PubMed

Mankan, Arun K; Müller, Martina; Witte, Gregor; Hornung, Veit

2017-01-01

First discovered in prokaryotes and more recently in eukaryotes, cyclic dinucleotides (CDNs) constitute a unique branch of second messenger signaling systems. Within prokaryotes CDNs regulate a wide array of different biological processes, whereas in the vertebrate system CDN signaling is largely dedicated to activation of the innate immune system. In this book chapter we summarize the occurrence and signaling pathways of these small-molecule second messengers, most importantly in the scope of the mammalian immune system. In this regard, our main focus is the role of the cGAS-STING axis in the context of microbial infection and sterile inflammation and its implications for therapeutic applications.

Implementation of a Readout Circuit on SOI Technology for the Signal Conditioning of a Neutron Detector in Harsh Environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ben Krit, S.; Coulie-Castellani, K.; Rahajandraibe, W.

2015-07-01

A transistor level implementation of the analog block of a readout system on SOI process is presented here. This system is dedicated to the signal conditioning of a neutron detector in harsh environment. The different parts of the readout circuits are defined. The harsh environment constraints (crossing particle effect, high temperatures) are also detailed and modeled in the circuit in order to test and evaluate the characteristics of the designed block when working under these conditions. (authors)

FPGA-Based Pulse Pile-Up Correction With Energy and Timing Recovery.

PubMed

Haselman, M D; Pasko, J; Hauck, S; Lewellen, T K; Miyaoka, R S

2012-10-01

Modern field programmable gate arrays (FPGAs) are capable of performing complex discrete signal processing algorithms with clock rates well above 100 MHz. This, combined with FPGA's low expense, ease of use, and selected dedicated hardware make them an ideal technology for a data acquisition system for a positron emission tomography (PET) scanner. The University of Washington is producing a high-resolution, small-animal PET scanner that utilizes FPGAs as the core of the front-end electronics. For this scanner, functions that are typically performed in dedicated circuits, or offline, are being migrated to the FPGA. This will not only simplify the electronics, but the features of modern FPGAs can be utilized to add significant signal processing power to produce higher quality images. In this paper we report on an all-digital pulse pile-up correction algorithm that has been developed for the FPGA. The pile-up mitigation algorithm will allow the scanner to run at higher count rates without incurring large data losses due to the overlapping of scintillation signals. This correction technique utilizes a reference pulse to extract timing and energy information for most pile-up events. Using pulses acquired from a Zecotech Photonics MAPD-N with an LFS-3 scintillator, we show that good timing and energy information can be achieved in the presence of pile-up utilizing a moderate amount of FPGA resources.

Packet based serial link realized in FPGA dedicated for high resolution infrared image transmission

NASA Astrophysics Data System (ADS)

Bieszczad, Grzegorz

2015-05-01

In article the external digital interface specially designed for thermographic camera built in Military University of Technology is described. The aim of article is to illustrate challenges encountered during design process of thermal vision camera especially related to infrared data processing and transmission. Article explains main requirements for interface to transfer Infra-Red or Video digital data and describes the solution which we elaborated based on Low Voltage Differential Signaling (LVDS) physical layer and signaling scheme. Elaborated link for image transmission is built using FPGA integrated circuit with built-in high speed serial transceivers achieving up to 2500Gbps throughput. Image transmission is realized using proprietary packet protocol. Transmission protocol engine was described in VHDL language and tested in FPGA hardware. The link is able to transmit 1280x1024@60Hz 24bit video data using one signal pair. Link was tested to transmit thermal-vision camera picture to remote monitor. Construction of dedicated video link allows to reduce power consumption compared to solutions with ASIC based encoders and decoders realizing video links like DVI or packed based Display Port, with simultaneous reduction of wires needed to establish link to one pair. Article describes functions of modules integrated in FPGA design realizing several functions like: synchronization to video source, video stream packeting, interfacing transceiver module and dynamic clock generation for video standard conversion.

High frequency signal acquisition and control system based on DSP+FPGA

NASA Astrophysics Data System (ADS)

Liu, Xiao-qi; Zhang, Da-zhi; Yin, Ya-dong

2017-10-01

This paper introduces a design and implementation of high frequency signal acquisition and control system based on DSP + FPGA. The system supports internal/external clock and internal/external trigger sampling. It has a maximum sampling rate of 400MBPS and has a 1.4GHz input bandwidth for the ADC. Data can be collected continuously or periodically in systems and they are stored in DDR2. At the same time, the system also supports real-time acquisition, the collected data after digital frequency conversion and Cascaded Integrator-Comb (CIC) filtering, which then be sent to the CPCI bus through the high-speed DSP, can be assigned to the fiber board for subsequent processing. The system integrates signal acquisition and pre-processing functions, which uses high-speed A/D, high-speed DSP and FPGA mixed technology and has a wide range of uses in data acquisition and recording. In the signal processing, the system can be seamlessly connected to the dedicated processor board. The system has the advantages of multi-selectivity, good scalability and so on, which satisfies the different requirements of different signals in different projects.

Biomedical signal and image processing.

PubMed

Cerutti, Sergio; Baselli, Giuseppe; Bianchi, Anna; Caiani, Enrico; Contini, Davide; Cubeddu, Rinaldo; Dercole, Fabio; Rienzo, Luca; Liberati, Diego; Mainardi, Luca; Ravazzani, Paolo; Rinaldi, Sergio; Signorini, Maria; Torricelli, Alessandro

2011-01-01

Generally, physiological modeling and biomedical signal processing constitute two important paradigms of biomedical engineering (BME): their fundamental concepts are taught starting from undergraduate studies and are more completely dealt with in the last years of graduate curricula, as well as in Ph.D. courses. Traditionally, these two cultural aspects were separated, with the first one more oriented to physiological issues and how to model them and the second one more dedicated to the development of processing tools or algorithms to enhance useful information from clinical data. A practical consequence was that those who did models did not do signal processing and vice versa. However, in recent years,the need for closer integration between signal processing and modeling of the relevant biological systems emerged very clearly [1], [2]. This is not only true for training purposes(i.e., to properly prepare the new professional members of BME) but also for the development of newly conceived research projects in which the integration between biomedical signal and image processing (BSIP) and modeling plays a crucial role. Just to give simple examples, topics such as brain–computer machine or interfaces,neuroengineering, nonlinear dynamical analysis of the cardiovascular (CV) system,integration of sensory-motor characteristics aimed at the building of advanced prostheses and rehabilitation tools, and wearable devices for vital sign monitoring and others do require an intelligent fusion of modeling and signal processing competences that are certainly peculiar of our discipline of BME.

A real-time GNSS-R system based on software-defined radio and graphics processing units

NASA Astrophysics Data System (ADS)

Hobiger, Thomas; Amagai, Jun; Aida, Masanori; Narita, Hideki

2012-04-01

Reflected signals of the Global Navigation Satellite System (GNSS) from the sea or land surface can be utilized to deduce and monitor physical and geophysical parameters of the reflecting area. Unlike most other remote sensing techniques, GNSS-Reflectometry (GNSS-R) operates as a passive radar that takes advantage from the increasing number of navigation satellites that broadcast their L-band signals. Thereby, most of the GNSS-R receiver architectures are based on dedicated hardware solutions. Software-defined radio (SDR) technology has advanced in the recent years and enabled signal processing in real-time, which makes it an ideal candidate for the realization of a flexible GNSS-R system. Additionally, modern commodity graphic cards, which offer massive parallel computing performances, allow to handle the whole signal processing chain without interfering with the PC's CPU. Thus, this paper describes a GNSS-R system which has been developed on the principles of software-defined radio supported by General Purpose Graphics Processing Units (GPGPUs), and presents results from initial field tests which confirm the anticipated capability of the system.

A Vision for MSSP

NASA Astrophysics Data System (ADS)

Mottershead, John E.

2015-05-01

MSSP is our journal. It developed out of the research community and in that sense is owned by us, its readers and authors. It was started by a small group, all international leaders in System Identification, Measurement and Signal Processing, Modal Analysis, Machine and Structural Diagnostics etc., several of whom still provide invaluable advice and guidance through their work on the Editorial Board. Most importantly, Simon's leadership for almost three decades has been inspirational, dedicated and energetic. So, it is a great honour for me to have been invited to assume the editorial leadership of MSSP and continue the work of serving a new generation of researchers in the broad and evolving field of Mechanical Systems and Signal Processing.

Porting Gravitational Wave Signal Extraction to Parallel Virtual Machine (PVM)

NASA Technical Reports Server (NTRS)

Thirumalainambi, Rajkumar; Thompson, David E.; Redmon, Jeffery

2009-01-01

Laser Interferometer Space Antenna (LISA) is a planned NASA-ESA mission to be launched around 2012. The Gravitational Wave detection is fundamentally the determination of frequency, source parameters, and waveform amplitude derived in a specific order from the interferometric time-series of the rotating LISA spacecrafts. The LISA Science Team has developed a Mock LISA Data Challenge intended to promote the testing of complicated nested search algorithms to detect the 100-1 millihertz frequency signals at amplitudes of 10E-21. However, it has become clear that, sequential search of the parameters is very time consuming and ultra-sensitive; hence, a new strategy has been developed. Parallelization of existing sequential search algorithms of Gravitational Wave signal identification consists of decomposing sequential search loops, beginning with outermost loops and working inward. In this process, the main challenge is to detect interdependencies among loops and partitioning the loops so as to preserve concurrency. Existing parallel programs are based upon either shared memory or distributed memory paradigms. In PVM, master and node programs are used to execute parallelization and process spawning. The PVM can handle process management and process addressing schemes using a virtual machine configuration. The task scheduling and the messaging and signaling can be implemented efficiently for the LISA Gravitational Wave search process using a master and 6 nodes. This approach is accomplished using a server that is available at NASA Ames Research Center, and has been dedicated to the LISA Data Challenge Competition. Historically, gravitational wave and source identification parameters have taken around 7 days in this dedicated single thread Linux based server. Using PVM approach, the parameter extraction problem can be reduced to within a day. The low frequency computation and a proxy signal-to-noise ratio are calculated in separate nodes that are controlled by the master using message and vector of data passing. The message passing among nodes follows a pattern of synchronous and asynchronous send-and-receive protocols. The communication model and the message buffers are allocated dynamically to address rapid search of gravitational wave source information in the Mock LISA data sets.

Dental MRI using a dedicated RF-coil at 3 Tesla.

PubMed

Prager, Marcel; Heiland, Sabine; Gareis, Daniel; Hilgenfeld, Tim; Bendszus, Martin; Gaudino, Chiara

2015-12-01

To assess the benefit of a dedicated surface coil to visualize dental structures in comparison to standard head/neck coil. Measurements were performed using the standard head/neck coil and a dedicated array coil for dental MRI at 3 T. As MRI methods, we used a T1-weighted spin-echo sequence with and without spectral fat saturation, a T2-weighted turbo-spin-echo sequence and a 3-dimensional T2-weighted SPACE sequence. Measurements were performed in a phantom to examine sensitivity profiles. Then the signal gain in dental structures was examined in volunteers and in a patient. As expected for a surface coil, the signal gain of the dental coil was highest at the surface of the phantom and decreased with increasing distance to the coil; it was >120% even at a depth of 30 mm, measured from the centre of the coil. The signal gain within the pulp of the volunteers ranged between 236 and 413%. The dedicated array coil offers a significantly higher signal within the region of interest for dental MR imaging thus allowing for better depiction of pathologies within the periodontium and for delineation and tracking of the branches of the maxillary and mandibular nerves. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Enhanced adaptive signal control using dedicated short-range communications.

DOT National Transportation Integrated Search

2014-05-01

Connected vehicle technology with dedicated short-range communications can provide traffic : information in a spatial domain that conventional fixed-point detectors cannot provide. However, because : of low market penetration with this new data sourc...

Satellite on-board real-time SAR processor prototype

NASA Astrophysics Data System (ADS)

Bergeron, Alain; Doucet, Michel; Harnisch, Bernd; Suess, Martin; Marchese, Linda; Bourqui, Pascal; Desnoyers, Nicholas; Legros, Mathieu; Guillot, Ludovic; Mercier, Luc; Châteauneuf, François

2017-11-01

A Compact Real-Time Optronic SAR Processor has been successfully developed and tested up to a Technology Readiness Level of 4 (TRL4), the breadboard validation in a laboratory environment. SAR, or Synthetic Aperture Radar, is an active system allowing day and night imaging independent of the cloud coverage of the planet. The SAR raw data is a set of complex data for range and azimuth, which cannot be compressed. Specifically, for planetary missions and unmanned aerial vehicle (UAV) systems with limited communication data rates this is a clear disadvantage. SAR images are typically processed electronically applying dedicated Fourier transformations. This, however, can also be performed optically in real-time. Originally the first SAR images were optically processed. The optical Fourier processor architecture provides inherent parallel computing capabilities allowing real-time SAR data processing and thus the ability for compression and strongly reduced communication bandwidth requirements for the satellite. SAR signal return data are in general complex data. Both amplitude and phase must be combined optically in the SAR processor for each range and azimuth pixel. Amplitude and phase are generated by dedicated spatial light modulators and superimposed by an optical relay set-up. The spatial light modulators display the full complex raw data information over a two-dimensional format, one for the azimuth and one for the range. Since the entire signal history is displayed at once, the processor operates in parallel yielding real-time performances, i.e. without resulting bottleneck. Processing of both azimuth and range information is performed in a single pass. This paper focuses on the onboard capabilities of the compact optical SAR processor prototype that allows in-orbit processing of SAR images. Examples of processed ENVISAT ASAR images are presented. Various SAR processor parameters such as processing capabilities, image quality (point target analysis), weight and size are reviewed.

Software Defined Radio (SDR) and Direct Digital Synthesizer (DDS) for NMR/MRI instruments at low-field.

PubMed

Asfour, Aktham; Raoof, Kosai; Yonnet, Jean-Paul

2013-11-27

A proof-of-concept of the use of a fully digital radiofrequency (RF) electronics for the design of dedicated Nuclear Magnetic Resonance (NMR) systems at low-field (0.1 T) is presented. This digital electronics is based on the use of three key elements: a Direct Digital Synthesizer (DDS) for pulse generation, a Software Defined Radio (SDR) for a digital receiving of NMR signals and a Digital Signal Processor (DSP) for system control and for the generation of the gradient signals (pulse programmer). The SDR includes a direct analog-to-digital conversion and a Digital Down Conversion (digital quadrature demodulation, decimation filtering, processing gain…). The various aspects of the concept and of the realization are addressed with some details. These include both hardware design and software considerations. One of the underlying ideas is to enable such NMR systems to "enjoy" from existing advanced technology that have been realized in other research areas, especially in telecommunication domain. Another goal is to make these systems easy to build and replicate so as to help research groups in realizing dedicated NMR desktops for a large palette of new applications. We also would like to give readers an idea of the current trends in this field. The performances of the developed electronics are discussed throughout the paper. First FID (Free Induction Decay) signals are also presented. Some development perspectives of our work in the area of low-field NMR/MRI will be finally addressed.

Electro-optic voltage sensor with Multiple Beam Splitting

DOEpatents

Woods, Gregory K.; Renak, Todd W.; Crawford, Thomas M.; Davidson, James R.

2000-01-01

A miniature electro-optic voltage sensor system capable of accurate operation at high voltages without use of the dedicated voltage dividing hardware. The invention achieves voltage measurement without significant error contributions from neighboring conductors or environmental perturbations. The invention employs a transmitter, a sensor, a detector, and a signal processor. The transmitter produces a beam of electromagnetic radiation which is routed into the sensor. Within the sensor the beam undergoes the Pockels electro-optic effect. The electro-optic effect produces a modulation of the beam's polarization, which is in turn converted to a pair of independent conversely-amplitude-modulated signals, from which the voltage of the E-field is determined by the signal processor. The use of converse AM signals enables the signal processor to better distinguish signal from noise. The sensor converts the beam by splitting the beam in accordance with the axes of the beam's polarization state (an ellipse) into at least two AM signals. These AM signals are fed into a signal processor and processed to determine the voltage between a ground conductor and the conductor on which voltage is being measured.

Stepped-frequency GPR for utility line detection using polarization-dependent scattering

NASA Astrophysics Data System (ADS)

Jensen, Ole K.; Gregersen, Ole G.

2000-04-01

A GPR for detection of buried cables and pipes is developed by Ekko Dane Production in cooperation with Aalborg University. The appearance is a 'lawn mower' model including antennas, electronics and on-line data processing. A successful result is obtained by combining dedicated hardware and signal processing. The inherent signal to clutter ratio is bad, but making measurements at many polarization angles and subsequent signal processing improves the ratio. A simple model of the polarization dependence of the scattering from the target is used. The method is improved by combining the polarization filtering with averaging over small horizontal displacements. A stepped frequency measurement system is used. The method often implies long measurement times, but this problem is overcome by development of fast RF-electronics. Standard signal processors are used for real-time data processing. Several antenna array configurations are tested and optimized for low coupling between transmitter and receiver and for a short impulse response. A large number of tests have been made for different targets, e.g. metal cables and plastic pipes filled with air or water. Tests have been made under realistic ground conditions, including sand, wet clay, pavements and grass covered soil. The results show reliable detection even when the conditions are difficult.

Ultranarrowband searches for extraterrestrial intelligence with dedicated signal-processing hardware

NASA Technical Reports Server (NTRS)

Horowitz, P.; Matthews, B. S.; Forster, J.; Linscott, I.; Teague, C. C.; Chen, K.; Backus, P.

1986-01-01

An evaluation is made of the prospects for SETI applications of multichannel spectroscopy, assuming narrowband RF beacon transmission, with a mHz resolution that matches interstellar medium properties. Receiver Doppler corrections must furnish substantial interference rejection. Results are presented from an Arecibo antenna search of 250 sunlike stars at 1.4 and 2.8 GHz. A meridian transit search of the northern sky is also in progress with the Harvard-Smithsonian 26-m antenna.

Radioastronomic signal processing cores for the SKA radio telescope

NASA Astrophysics Data System (ADS)

Comorett, G.; Chiarucc, S.; Belli, C.

Modern radio telescopes require the processing of wideband signals, with sample rates from tens of MHz to tens of GHz, and are composed from hundreds up to a million of individual antennas. Digital signal processing of these signals include digital receivers (the digital equivalent of the heterodyne receiver), beamformers, channelizers, spectrometers. FPGAs present the advantage of providing a relatively low power consumption, relative to GPUs or dedicated computers, a wide signal data path, and high interconnectivity. Efficient algorithms have been developed for these applications. Here we will review some of the signal processing cores developed for the SKA telescope. The LFAA beamformer/channelizer architecture is based on an oversampling channelizer, where the channelizer output sampling rate and channel spacing can be set independently. This is useful where an overlap between adjacent channels is required to provide an uniform spectral coverage. The architecture allows for an efficient and distributed channelization scheme, with a final resolution corresponding to a million of spectral channels, minimum leakage and high out-of-band rejection. An optimized filter design procedure is used to provide an equiripple response with a very large number of spectral channels. A wideband digital receiver has been designed in order to select the processed bandwidth of the SKA Mid receiver. The receiver extracts a 2.5 MHz bandwidth form a 14 GHz input bandwidth. The design allows for non-integer ratios between the input and output sampling rates, with a resource usage comparable to that of a conventional decimating digital receiver. Finally, some considerations on quantization of radioastronomic signals are presented. Due to the stochastic nature of the signal, quantization using few data bits is possible. Good accuracies and dynamic range are possible even with 2-3 bits, but the nonlinearity in the correlation process must be corrected in post-processing. With at least 6 bits it is possible to have a very linear response of the instrument, with nonlinear terms below 80 dB, providing the signal amplitude is kept within bounds.

Digitally enhanced homodyne interferometry.

PubMed

Sutton, Andrew J; Gerberding, Oliver; Heinzel, Gerhard; Shaddock, Daniel A

2012-09-24

We present two variations of a novel interferometry technique capable of simultaneously measuring multiple targets with high sensitivity. The technique performs a homodyne phase measurement by application of a four point phase shifting algorithm, with pseudo-random switching between points to allow multiplexed measurement based upon propagation delay alone. By multiplexing measurements and shifting complexity into signal processing, both variants realise significant complexity reductions over comparable methods. The first variant performs a typical coherent detection with a dedicated reference field and achieves a displacement noise floor 0.8 pm/√Hz above 50 Hz. The second allows for removal of the dedicated reference, resulting in further simplifications and improved low frequency performance with a 1 pm/√Hz noise floor measured down to 20 Hz. These results represent the most sensitive measurement performed using this style of interferometry whilst simultaneously reducing the electro-optic footprint.

Improved high-throughput quantification of luminescent microplate assays using a common Western-blot imaging system.

PubMed

Hawkins, Liam J; Storey, Kenneth B

2017-01-01

Common Western-blot imaging systems have previously been adapted to measure signals from luminescent microplate assays. This can be a cost saving measure as Western-blot imaging systems are common laboratory equipment and could substitute a dedicated luminometer if one is not otherwise available. One previously unrecognized limitation is that the signals captured by the cameras in these systems are not equal for all wells. Signals are dependent on the angle of incidence to the camera, and thus the location of the well on the microplate. Here we show that: •The position of a well on a microplate significantly affects the signal captured by a common Western-blot imaging system from a luminescent assay.•The effect of well position can easily be corrected for.•This method can be applied to commercially available luminescent assays, allowing for high-throughput quantification of a wide range of biological processes and biochemical reactions.

VLSI implementation of a new LMS-based algorithm for noise removal in ECG signal

NASA Astrophysics Data System (ADS)

Satheeskumaran, S.; Sabrigiriraj, M.

2016-06-01

Least mean square (LMS)-based adaptive filters are widely deployed for removing artefacts in electrocardiogram (ECG) due to less number of computations. But they posses high mean square error (MSE) under noisy environment. The transform domain variable step-size LMS algorithm reduces the MSE at the cost of computational complexity. In this paper, a variable step-size delayed LMS adaptive filter is used to remove the artefacts from the ECG signal for improved feature extraction. The dedicated digital Signal processors provide fast processing, but they are not flexible. By using field programmable gate arrays, the pipelined architectures can be used to enhance the system performance. The pipelined architecture can enhance the operation efficiency of the adaptive filter and save the power consumption. This technique provides high signal-to-noise ratio and low MSE with reduced computational complexity; hence, it is a useful method for monitoring patients with heart-related problem.

Perception SoC Based on an Ultrasonic Array of Sensors: Efficient DSP Core Implementation and Subsequent Experimental Results

NASA Astrophysics Data System (ADS)

Kassem, A.; Sawan, M.; Boukadoum, M.; Haidar, A.

2005-12-01

We are concerned with the design, implementation, and validation of a perception SoC based on an ultrasonic array of sensors. The proposed SoC is dedicated to ultrasonic echography applications. A rapid prototyping platform is used to implement and validate the new architecture of the digital signal processing (DSP) core. The proposed DSP core efficiently integrates all of the necessary ultrasonic B-mode processing modules. It includes digital beamforming, quadrature demodulation of RF signals, digital filtering, and envelope detection of the received signals. This system handles 128 scan lines and 6400 samples per scan line with a[InlineEquation not available: see fulltext.] angle of view span. The design uses a minimum size lookup memory to store the initial scan information. Rapid prototyping using an ARM/FPGA combination is used to validate the operation of the described system. This system offers significant advantages of portability and a rapid time to market.

A Subsystem Test Bed for Chinese Spectral Radioheliograph

NASA Astrophysics Data System (ADS)

Zhao, An; Yan, Yihua; Wang, Wei

2014-11-01

The Chinese Spectral Radioheliograph is a solar dedicated radio interferometric array that will produce high spatial resolution, high temporal resolution, and high spectral resolution images of the Sun simultaneously in decimetre and centimetre wave range. Digital processing of intermediate frequency signal is an important part in a radio telescope. This paper describes a flexible and high-speed digital down conversion system for the CSRH by applying complex mixing, parallel filtering, and extracting algorithms to process IF signal at the time of being designed and incorporates canonic-signed digit coding and bit-plane method to improve program efficiency. The DDC system is intended to be a subsystem test bed for simulation and testing for CSRH. Software algorithms for simulation and hardware language algorithms based on FPGA are written which use less hardware resources and at the same time achieve high performances such as processing high-speed data flow (1 GHz) with 10 MHz spectral resolution. An experiment with the test bed is illustrated by using geostationary satellite data observed on March 20, 2014. Due to the easy alterability of the algorithms on FPGA, the data can be recomputed with different digital signal processing algorithms for selecting optimum algorithm.

Input reconstruction for networked control systems subject to deception attacks and data losses on control signals

NASA Astrophysics Data System (ADS)

Keller, J. Y.; Chabir, K.; Sauter, D.

2016-03-01

State estimation of stochastic discrete-time linear systems subject to unknown inputs or constant biases has been widely studied but no work has been dedicated to the case where a disturbance switches between unknown input and constant bias. We show that such disturbance can affect a networked control system subject to deception attacks and data losses on the control signals transmitted by the controller to the plant. This paper proposes to estimate the switching disturbance from an augmented state version of the intermittent unknown input Kalman filter recently developed by the authors. Sufficient stochastic stability conditions are established when the arrival binary sequence of data losses follows a Bernoulli random process.

Shared motion signals for human perceptual decisions and oculomotor actions

NASA Technical Reports Server (NTRS)

Stone, Leland S.; Krauzlis, Richard J.

2003-01-01

A fundamental question in primate neurobiology is to understand to what extent motor behaviors are driven by shared neural signals that also support conscious perception or by independent subconscious neural signals dedicated to motor control. Although it has clearly been established that cortical areas involved in processing visual motion support both perception and smooth pursuit eye movements, it remains unknown whether the same or different sets of neurons within these structures perform these two functions. Examination of the trial-by-trial variation in human perceptual and pursuit responses during a simultaneous psychophysical and oculomotor task reveals that the direction signals for pursuit and perception are not only similar on average but also co-vary on a trial-by-trial basis, even when performance is at or near chance and the decisions are determined largely by neural noise. We conclude that the neural signal encoding the direction of target motion that drives steady-state pursuit and supports concurrent perceptual judgments emanates from a shared ensemble of cortical neurons.

Optimal filter design with progressive genetic algorithm for local damage detection in rolling bearings

NASA Astrophysics Data System (ADS)

Wodecki, Jacek; Michalak, Anna; Zimroz, Radoslaw

2018-03-01

Harsh industrial conditions present in underground mining cause a lot of difficulties for local damage detection in heavy-duty machinery. For vibration signals one of the most intuitive approaches of obtaining signal with expected properties, such as clearly visible informative features, is prefiltration with appropriately prepared filter. Design of such filter is very broad field of research on its own. In this paper authors propose a novel approach to dedicated optimal filter design using progressive genetic algorithm. Presented method is fully data-driven and requires no prior knowledge of the signal. It has been tested against a set of real and simulated data. Effectiveness of operation has been proven for both healthy and damaged case. Termination criterion for evolution process was developed, and diagnostic decision making feature has been proposed for final result determinance.

Fast-Acquisition/Weak-Signal-Tracking GPS Receiver for HEO

NASA Technical Reports Server (NTRS)

Wintemitz, Luke; Boegner, Greg; Sirotzky, Steve

2004-01-01

A report discusses the technical background and design of the Navigator Global Positioning System (GPS) receiver -- . a radiation-hardened receiver intended for use aboard spacecraft. Navigator is capable of weak signal acquisition and tracking as well as much faster acquisition of strong or weak signals with no a priori knowledge or external aiding. Weak-signal acquisition and tracking enables GPS use in high Earth orbits (HEO), and fast acquisition allows for the receiver to remain without power until needed in any orbit. Signal acquisition and signal tracking are, respectively, the processes of finding and demodulating a signal. Acquisition is the more computationally difficult process. Previous GPS receivers employ the method of sequentially searching the two-dimensional signal parameter space (code phase and Doppler). Navigator exploits properties of the Fourier transform in a massively parallel search for the GPS signal. This method results in far faster acquisition times [in the lab, 12 GPS satellites have been acquired with no a priori knowledge in a Low-Earth-Orbit (LEO) scenario in less than one second]. Modeling has shown that Navigator will be capable of acquiring signals down to 25 dB-Hz, appropriate for HEO missions. Navigator is built using the radiation-hardened ColdFire microprocessor and housing the most computationally intense functions in dedicated field-programmable gate arrays. The high performance of the algorithm and of the receiver as a whole are made possible by optimizing computational efficiency and carefully weighing tradeoffs among the sampling rate, data format, and data-path bit width.

A low-noise measurement system for scanning thermal microscopy resistive nanoprobes based on a transformer ratio-arm bridge

NASA Astrophysics Data System (ADS)

Świątkowski, Michał; Wojtuś, Arkadiusz; Wielgoszewski, Grzegorz; Rudek, Maciej; Piasecki, Tomasz; Jóźwiak, Grzegorz; Gotszalk, Teodor

2018-04-01

Atomic force microscopy (AFM) is a widely used technology for the investigation and characterization of nanomaterials. Its functionality can be easily expanded by applying dedicated extension modules, which can measure the electrical conductivity or temperature of a sample. In this paper, we introduce a transformer ratio-arm bridge setup dedicated to AFM-based thermal imaging. One of the key features of the thermal module is the use of a low-power driving signal that prevents undesirable tip heating during resistance measurement, while the other is the sensor location in a ratio-arm transformer bridge working in the audio frequency range and ensuring galvanic isolation of the tip, enabling contact-mode scanning of electronic circuits. The proposed expansion module is compact and it can be integrated onto the AFM head close to the cantilever. The calibration process and the resolution of 11 mK of the proposed setup are shown.

Focusing effect of bent GaAs crystals for γ-ray Laue lenses: Monte Carlo and experimental results

NASA Astrophysics Data System (ADS)

Virgilli, E.; Frontera, F.; Rosati, P.; Bonnini, E.; Buffagni, E.; Ferrari, C.; Stephen, J. B.; Caroli, E.; Auricchio, N.; Basili, A.; Silvestri, S.

2016-02-01

We report on results of observation of the focusing effect from the planes (220) of Gallium Arsenide (GaAs) crystals. We have compared the experimental results with the Monte Carlo simulations of the focusing capability of GaAs tiles performed with a dedicated ray-tracer. The GaAs tiles were bent using a lapping process developed at the cnr/imem - Parma (Italy) in the framework of the laue project, funded by ASI, dedicated to build a broad band Laue lens prototype for astrophysical applications in the hard X-/soft γ-ray energy range (80-600 keV). We present and discuss the results obtained from their characterization, mainly in terms of focusing capability. Bent crystals will significantly increase the signal to noise ratio of a telescope based on a Laue lens, consequently leading to an unprecedented enhancement of sensitivity with respect to the present non focusing instrumentation.

WebBioBank: a new platform for integrating clinical forms and shared neurosignal analyses to support multi-centre studies in Parkinson's Disease.

PubMed

Rossi, Elena; Rosa, Manuela; Rossi, Lorenzo; Priori, Alberto; Marceglia, Sara

2014-12-01

The web-based systems available for multi-centre clinical trials do not combine clinical data collection (Electronic Health Records, EHRs) with signal processing storage and analysis tools. However, in pathophysiological research, the correlation between clinical data and signals is crucial for uncovering the underlying neurophysiological mechanisms. A specific example is the investigation of the mechanisms of action for Deep Brain Stimulation (DBS) used for Parkinson's Disease (PD); the neurosignals recorded from the DBS target structure and clinical data must be investigated. The aim of this study is the development and testing of a new system dedicated to a multi-centre study of Parkinson's Disease that integrates biosignal analysis tools and data collection in a shared and secure environment. We designed a web-based platform (WebBioBank) for managing the clinical data and biosignals of PD patients treated with DBS in different clinical research centres. Homogeneous data collection was ensured in the different centres (Operative Units, OUs). The anonymity of the data was preserved using unique identifiers associated with patients (ID BAC). The patients' personal details and their equivalent ID BACs were archived inside the corresponding OU and were not uploaded on the web-based platform; data sharing occurred using the ID BACs. The system allowed researchers to upload different signal processing functions (in a .dll extension) onto the web-based platform and to combine them to define dedicated algorithms. Four clinical research centres used WebBioBank for 1year. The clinical data from 58 patients treated using DBS were managed, and 186 biosignals were uploaded and classified into 4 categories based on the treatment (pharmacological and/or electrical). The user's satisfaction mean score exceeded the satisfaction threshold. WebBioBank enabled anonymous data sharing for a clinical study conducted at multiple centres and demonstrated the capabilities of the signal processing chain configuration as well as its effectiveness and efficiency for integrating the neurophysiological results with clinical data in multi-centre studies, which will allow the future collection of homogeneous data in large cohorts of patients. Copyright © 2014 Elsevier Inc. All rights reserved.

Chromospheric LAyer SpectroPolarimeter (CLASP2)

NASA Technical Reports Server (NTRS)

Narukage, Noriyuki; Cirtain, Jonathan W.; Ishikawa, Ryoko; Trujillo-Bueno, Javier; De Pontieu, Bart; Kubo, Masahito; Ishikawa, Shinnosuke; Kano, Ryohei; Suematsu, Yoshinori; Yoshida, Masaki;

SALT, a dedicated readout chip for high precision tracking silicon strip detectors at the LHCb Upgrade

NASA Astrophysics Data System (ADS)

Bugiel, Sz.; Dasgupta, R.; Firlej, M.; Fiutowski, T.; Idzik, M.; Kuczynska, M.; Moron, J.; Swientek, K.; Szumlak, T.

2016-02-01

The Upstream Tracker (UT) silicon strip detector, one of the central parts of the tracker system of the modernised LHCb experiment, will use a new 128-channel readout ASIC called SALT. It will extract and digitise analogue signals from the UT sensors, perform digital signal processing and transmit a serial output data. The SALT is being designed in CMOS 130 nm process and uses a novel architecture comprising of analog front-end and fast (40 MSps) ultra-low power (<0.5 mW) 6-bit ADC in each channel. The prototype ASICs of important functional blocks, like analogue front-end, 6-bit SAR ADC, PLL, and DLL, were designed, fabricated and tested. A prototype of an 8-channel version of the SALT chip, comprising all important functionalities was also designed and fabricated. The architecture and design of the SALT, together with the selected preliminary tests results, are presented.

Electro-optic voltage sensor with beam splitting

DOEpatents

Woods, Gregory K.; Renak, Todd W.; Davidson, James R.; Crawford, Thomas M.

2002-01-01

The invention is a miniature electro-optic voltage sensor system capable of accurate operation at high voltages without use of the dedicated voltage dividing hardware typically found in the prior art. The invention achieves voltage measurement without significant error contributions from neighboring conductors or environmental perturbations. The invention employs a transmitter, a sensor, a detector, and a signal processor. The transmitter produces a beam of electromagnetic radiation which is routed into the sensor. Within the sensor the beam undergoes the Pockels electro-optic effect. The electro-optic effect produces a modulation of the beam's polarization, which is in turn converted to a pair of independent conversely-amplitude-modulated signals, from which the voltage of the E-field is determined by the signal processor. The use of converse AM signals enables the signal processor to better distinguish signal from noise. The sensor converts the beam by splitting the beam in accordance with the axes of the beam's polarization state (an ellipse) into at least two AM signals. These AM signals are fed into a signal processor and processed to determine the voltage between a ground conductor and the conductor on which voltage is being measured.

IMOTEPAD: A mixed-signal 64-channel front-end ASIC for small-animal PET imaging

NASA Astrophysics Data System (ADS)

Fang, Xiaochao; Ollivier-Henry, Nicolas; Gao, Wu; Hu-Guo, Christine; Colledani, Claude; Humbert, Bernard; Brasse, David; Hu, Yann

2011-04-01

This paper presents the design and characteristics of a mixed-signal 64-channel front-end readout ASIC called IMOTEPAD dedicated to multi-channel plate (MCP) photodetector coupled to LYSO scintillating crystals for small-animal PET imaging. In our configuration, the crystals are oriented in the axial direction readout on both sides by individual photodetector channels allowing the spatial resolution and the detection efficiency to be independent of each other. As a result, both energy signals and timing triggers from the photodetectors are required to be read out by the front-end ASIC. This dedicated ASIC IMOTEPAD comprises two parts: the analog part IMOTEPA and the digital part IMOTEPD. The IMOTEPA is dedicated to energy measurement. And the timing information is digitized by the IMOTEPD in which the key principal element is a time-to-digital converter (TDC) based on a delay-locked loop (DLL) with 32 delay cells. The chip is designed and fabricated in 0.35 μm CMOS process. The measurements show that for the analog part IMOTEPA, the energy gain is 13.1 mV/pC while the peak time of a CR-RC pulse shaper is 280 ns. The SNR is 39 dB and the RMS noise is 300 μV. The nonlinearity is less than 3%. The crosstalk is less than 0.2%. For the IMOTEPD, the bin size of the TDC is 625 ps with a reference clock of 50 MHz. The RMS jitter of the DLL is less than 42 ps. The DNL of the TDC is equal to about 0.17 LSB and the INL is equal to 0.31 LSB. The power dissipation of each channel is less than 16.8 mW. The design of the ASIC, especially for TDC and the measurement results of the IMOTEPAD will be presented and discussed in this paper.

A neural model of figure-ground organization.

PubMed

Craft, Edward; Schütze, Hartmut; Niebur, Ernst; von der Heydt, Rüdiger

2007-06-01

Psychophysical studies suggest that figure-ground organization is a largely autonomous process that guides--and thus precedes--allocation of attention and object recognition. The discovery of border-ownership representation in single neurons of early visual cortex has confirmed this view. Recent theoretical studies have demonstrated that border-ownership assignment can be modeled as a process of self-organization by lateral interactions within V2 cortex. However, the mechanism proposed relies on propagation of signals through horizontal fibers, which would result in increasing delays of the border-ownership signal with increasing size of the visual stimulus, in contradiction with experimental findings. It also remains unclear how the resulting border-ownership representation would interact with attention mechanisms to guide further processing. Here we present a model of border-ownership coding based on dedicated neural circuits for contour grouping that produce border-ownership assignment and also provide handles for mechanisms of selective attention. The results are consistent with neurophysiological and psychophysical findings. The model makes predictions about the hypothetical grouping circuits and the role of feedback between cortical areas.

Ideal-observer analysis of lesion detectability in planar, conventional SPECT, and dedicated SPECT scintimammography using effective multi-dimensional smoothing

NASA Astrophysics Data System (ADS)

La Riviere, P. J.; Pan, X.; Penney, B. C.

1998-06-01

Scintimammography, a nuclear-medicine imaging technique that relies on the preferential uptake of Tc-99m-sestamibi and other radionuclides in breast malignancies, has the potential to provide differentiation of mammographically suspicious lesions, as well as outright detection of malignancies in women with radiographically dense breasts. In this work we use the ideal-observer framework to quantify the detectability of a 1-cm lesion using three different imaging geometries: the planar technique that is the current clinical standard, conventional single-photon emission computed tomography (SPECT), in which the scintillation cameras rotate around the entire torso, and dedicated breast SPECT, in which the cameras rotate around the breast alone. We also introduce an adaptive smoothing technique for the processing of planar images and of sinograms that exploits Fourier transforms to achieve effective multidimensional smoothing at a reasonable computational cost. For the detection of a 1-cm lesion with a clinically typical 6:1 tumor-background ratio, we find ideal-observer signal-to-noise ratios (SNR) that suggest that the dedicated breast SPECT geometry is the most effective of the three, and that the adaptive, two-dimensional smoothing technique should enhance lesion detectability in the tomographic reconstructions.

Experimental facility for the study of acoustic emission registered in the primary circuit components of WWER power units

NASA Astrophysics Data System (ADS)

Petrosyan, V. G.; Hovakimyan, T. H.; Yeghoyan, E. A.; Hovhannisyan, H. T.; Mayilyan, D. G.; Petrosyan, A. P.

2017-01-01

This paper is dedicated to the creation of a facility for the experimental study of a phenomenon of background acoustic emission (AE), which is detected in the main circulation loop (MCL) of WWER power units. The analysis of the operating principle and the design of a primary feed-and-blow down system (FB) deaerator of NPP as the most likely source of continuous acoustic emission is carried out. The experimental facility for the systematic study of a phenomenon of continuous AE is developed. A physical model of a thermal deaerator is designed and constructed. A thermal monitoring system is introduced. An automatic system providing acoustic signal registration in a low frequency (0.03-30 kHz) and high frequency (30-300 kHz) bands and study of its spectral characteristics is designed. Special software for recording and processing of digitized electrical sensor signals is developed. A separate and independent principle of study of the most probable processes responsible for the generation of acoustic emission signals in the deaerator is applied. Trial series of experiments and prechecks of acoustic signals in different modes of the deaerator model are conducted. Compliance of basic technological parameters with operating range of the real deaerator was provided. It is shown that the acoustic signal time-intensity curve has several typical regions. The pilot research showed an impact of various processes that come about during the operation of the deaerator physical model on the intensity of the AE signal. The experimental results suggest that the main sources of generation of the AE signals are the processes of steam condensation, turbulent flow of gas-vapor medium, and water boiling.

High-Speed Data Acquisition and Digital Signal Processing System for PET Imaging Techniques Applied to Mammography

NASA Astrophysics Data System (ADS)

Martinez, J. D.; Benlloch, J. M.; Cerda, J.; Lerche, Ch. W.; Pavon, N.; Sebastia, A.

2004-06-01

This paper is framed into the Positron Emission Mammography (PEM) project, whose aim is to develop an innovative gamma ray sensor for early breast cancer diagnosis. Currently, breast cancer is detected using low-energy X-ray screening. However, functional imaging techniques such as PET/FDG could be employed to detect breast cancer and track disease changes with greater sensitivity. Furthermore, a small and less expensive PET camera can be utilized minimizing main problems of whole body PET. To accomplish these objectives, we are developing a new gamma ray sensor based on a newly released photodetector. However, a dedicated PEM detector requires an adequate data acquisition (DAQ) and processing system. The characterization of gamma events needs a free-running analog-to-digital converter (ADC) with sampling rates of more than 50 Ms/s and must achieve event count rates up to 10 MHz. Moreover, comprehensive data processing must be carried out to obtain event parameters necessary for performing the image reconstruction. A new generation digital signal processor (DSP) has been used to comply with these requirements. This device enables us to manage the DAQ system at up to 80 Ms/s and to execute intensive calculi over the detector signals. This paper describes our designed DAQ and processing architecture whose main features are: very high-speed data conversion, multichannel synchronized acquisition with zero dead time, a digital triggering scheme, and high throughput of data with an extensive optimization of the signal processing algorithms.

The string soundscape at gravitational wave detectors

NASA Astrophysics Data System (ADS)

Garcia Garcia, Isabel; Krippendorf, Sven; March-Russell, John

2018-04-01

We argue that gravitational wave signals due to collisions of ultra-relativistic bubble walls may be common in string theory. This occurs due to a process of post-inflationary vacuum decay via quantum tunnelling. Though we study a specific string construction involving warped throats, we argue that our conclusions are more general. Many such transitions could have occurred in the post-inflationary Universe, as a large number of throats with exponentially different mass scales can be present in the string landscape, leading to several signals of widely different frequencies - a soundscape connected to the landscape of vacua. Detectors such as aLIGO/VIRGO, LISA, and pulsar timing observations with SKA and EPTA have the sensitivity to detect such signals. A distribution of primordial black holes is also a likely consequence, though reliable estimates of masses and their abundance require dedicated numerical simulations, as do the fine details of the gravitational wave spectrum due to the unusual nature of the transition.

A high-speed digital signal processor for atmospheric radar, part 7.3A

NASA Technical Reports Server (NTRS)

Brosnahan, J. W.; Woodard, D. M.

1984-01-01

The Model SP-320 device is a monolithic realization of a complex general purpose signal processor, incorporating such features as a 32-bit ALU, a 16-bit x 16-bit combinatorial multiplier, and a 16-bit barrel shifter. The SP-320 is designed to operate as a slave processor to a host general purpose computer in applications such as coherent integration of a radar return signal in multiple ranges, or dedicated FFT processing. Presently available is an I/O module conforming to the Intel Multichannel interface standard; other I/O modules will be designed to meet specific user requirements. The main processor board includes input and output FIFO (First In First Out) memories, both with depths of 4096 W, to permit asynchronous operation between the source of data and the host computer. This design permits burst data rates in excess of 5 MW/s.

Exploitation of Ubiquitous Wi-Fi Devices as Building Blocks for Improvised Motion Detection Systems.

PubMed

Soldovieri, Francesco; Gennarelli, Gianluca

2016-02-27

This article deals with a feasibility study on the detection of human movements in indoor scenarios based on radio signal strength variations. The sensing principle exploits the fact that the human body interacts with wireless signals, introducing variations of the radiowave fields due to shadowing and multipath phenomena. As a result, human motion can be inferred from fluctuations of radiowave power collected by a receiving terminal. In this paper, we investigate the potentialities of widely available wireless communication devices in order to develop an improvised motion detection system (IMDS). Experimental tests are performed in an indoor environment by using a smartphone as a Wi-Fi access point and a laptop with dedicated software as a receiver. Simple detection strategies tailored for real-time operation are implemented to process the received signal strength measurements. The achieved results confirm the potentialities of the simple system here proposed to reliably detect human motion in operational conditions.

Development of a digital method for neutron/gamma-ray discrimination based on matched filtering

NASA Astrophysics Data System (ADS)

Korolczuk, S.; Linczuk, M.; Romaniuk, R.; Zychor, I.

2016-09-01

Neutron/gamma-ray discrimination is crucial for measurements with detectors sensitive to both neutron and gamma-ray radiation. Different techniques to discriminate between neutrons and gamma-rays based on pulse shape analysis are widely used in many applications, e.g., homeland security, radiation dosimetry, environmental monitoring, fusion experiments, nuclear spectroscopy. A common requirement is to improve a radiation detection level with a high detection reliability. Modern electronic components, such as high speed analog to digital converters and powerful programmable digital circuits for signal processing, allow us to develop a fully digital measurement system. With this solution it is possible to optimize digital signal processing algorithms without changing any electronic components in an acquisition signal path. We report on results obtained with a digital acquisition system DNG@NCBJ designed at the National Centre for Nuclear Research. A 2'' × 2'' EJ309 liquid scintillator was used to register mixed neutron and gamma-ray radiation from PuBe sources. A dedicated algorithm for pulse shape discrimination, based on real-time filtering, was developed and implemented in hardware.

Spatial focalization of pheromone/MAPK signaling triggers commitment to cell–cell fusion

PubMed Central

Merlini, Laura

2016-01-01

Cell fusion is universal in eukaryotes for fertilization and development, but what signals this process is unknown. Here, we show in Schizosaccharomyces pombe that fusion does not require a dedicated signal but is triggered by spatial focalization of the same pheromone–GPCR (G-protein-coupled receptor)–MAPK signaling cascade that drives earlier mating events. Autocrine cells expressing the receptor for their own pheromone trigger fusion attempts independently of cell–cell contact by concentrating pheromone release at the fusion focus, a dynamic actin aster underlying the secretion of cell wall hydrolases. Pheromone receptor and MAPK cascade are similarly enriched at the fusion focus, concomitant with fusion commitment in wild-type mating pairs. This focalization promotes cell fusion by immobilizing the fusion focus, thus driving local cell wall dissolution. We propose that fusion commitment is imposed by a local increase in MAPK concentration at the fusion focus, driven by a positive feedback between fusion focus formation and focalization of pheromone release and perception. PMID:27798845

Digital seismo-acoustic signal processing aboard a wireless sensor platform

NASA Astrophysics Data System (ADS)

Marcillo, O.; Johnson, J. B.; Lorincz, K.; Werner-Allen, G.; Welsh, M.

2006-12-01

We are developing a low power, low-cost wireless sensor array to conduct real-time signal processing of earthquakes at active volcanoes. The sensor array, which integrates data from both seismic and acoustic sensors, is based on Moteiv TMote Sky wireless sensor nodes (www.moteiv.com). The nodes feature a Texas Instruments MSP430 microcontroller, 48 Kbytes of program memory, 10 Kbytes of static RAM, 1 Mbyte of external flash memory, and a 2.4-GHz Chipcon CC2420 IEEE 802.15.4 radio. The TMote Sky is programmed in TinyOS. Basic signal processing occurs on an array of three peripheral sensor nodes. These nodes are tied into a dedicated GPS receiver node, which is focused on time synchronization, and a central communications node, which handles data integration and additional processing. The sensor nodes incorporate dual 12-bit digitizers sampling a seismic sensor and a pressure transducer at 100 samples per second. The wireless capabilities of the system allow flexible array geometry, with a maximum aperture of 200m. We have already developed the digital signal processing routines on board the Moteiv Tmote sensor nodes. The developed routines accomplish Real-time Seismic-Amplitude Measurement (RSAM), Seismic Spectral- Amplitude Measurement (SSAM), and a user-configured Short Term Averaging / Long Term Averaging (STA LTA ratio), which is used to calculate first arrivals. The processed data from individual nodes are transmitted back to a central node, where additional processing may be performed. Such processing will include back azimuth determination and other wave field analyses. Future on-board signal processing will focus on event characterization utilizing pattern recognition and spectral characterization. The processed data is intended as low bandwidth information which can be transmitted periodically and at low cost through satellite telemetry to a web server. The processing is limited by the computational capabilities (RAM, ROM) of the nodes. Nevertheless, we envision this product to be a useful tool for assessing the state of unrest at remote volcanoes.

Implementation Strategies for a Universal Acquisition and Tracking Channel Applied to Real GNSS Signals.

PubMed

Fortin, Marc-Antoine; Landry, René

2016-05-02

This paper presents a universal GNSS receiver channel capable of tracking any civil GNSS signal. This fundamentally differs from dedicated channels, each customized for a given signal. A mobile device could integrate fewer universal channels to harvest all available signals. This would allow securing signal availability, while minimizing power consumption and chip size, thus maximizing battery lifetime. In fact, the universal channel allows sequential acquisition and tracking of any chipping rate, carrier frequency, FDMA channel, modulation, or constellation, and is totally configurable (any integration time, any discriminator, etc.). It can switch from one signal to another in 1.07 ms, making it possible for the receiver to rapidly adapt to its sensed environment. All this would consume 3.5 mW/channel in an ASIC implementation, i.e., with a slight overhead compared to the original GPS L1 C/A dedicated channel from which it was derived. After extensive surveys on GNSS signals and tracking channels, this paper details the implementation strategies that led to the proposed universal channel architecture. Validation is achieved using GNSS signals issued from different constellations, frequency bands, modulations and spreading code schemes. A discussion on acquisition approaches and conclusive remarks follow, which open up a new signal selection challenge, rather than satellite selection.

Implementation Strategies for a Universal Acquisition and Tracking Channel Applied to Real GNSS Signals

PubMed Central

Fortin, Marc-Antoine; Landry, René

2016-01-01

This paper presents a universal GNSS receiver channel capable of tracking any civil GNSS signal. This fundamentally differs from dedicated channels, each customized for a given signal. A mobile device could integrate fewer universal channels to harvest all available signals. This would allow securing signal availability, while minimizing power consumption and chip size, thus maximizing battery lifetime. In fact, the universal channel allows sequential acquisition and tracking of any chipping rate, carrier frequency, FDMA channel, modulation, or constellation, and is totally configurable (any integration time, any discriminator, etc.). It can switch from one signal to another in 1.07 ms, making it possible for the receiver to rapidly adapt to its sensed environment. All this would consume 3.5 mW/channel in an ASIC implementation, i.e., with a slight overhead compared to the original GPS L1 C/A dedicated channel from which it was derived. After extensive surveys on GNSS signals and tracking channels, this paper details the implementation strategies that led to the proposed universal channel architecture. Validation is achieved using GNSS signals issued from different constellations, frequency bands, modulations and spreading code schemes. A discussion on acquisition approaches and conclusive remarks follow, which open up a new signal selection challenge, rather than satellite selection. PMID:27144569

Analog FM/FM versus digital color TV transmission aboard space station

NASA Technical Reports Server (NTRS)

Hart, M. M.

1985-01-01

Langley Research Center is developing an integrated fault tolerant network to support data, voice, and video communications aboard Space Station. The question of transmitting the video data via dedicated analog channels or converting it to the digital domain for consistancy with the test of the data is addressed. The recommendations in this paper are based on a comparison in the signal-to-noise ratio (SNR), the type of video processing required aboard Space Station, the applicability to Space Station, and how they integrate into the network.

Technical solutions for simultaneous MEG and SEEG recordings: towards routine clinical use.

PubMed

Badier, J M; Dubarry, A S; Gavaret, M; Chen, S; Trébuchon, A S; Marquis, P; Régis, J; Bartolomei, F; Bénar, C G; Carron, R

2017-09-21

The simultaneous recording of intracerebral EEG (stereotaxic EEG, SEEG) and magnetoencephalography (MEG) is a promising strategy that provides both local and global views on brain pathological activity. Yet, acquiring simultaneous signals poses difficult technical issues that hamper their use in clinical routine. Our objective was thus to develop a set of solutions for recording a high number of SEEG channels while preserving signal quality. We recorded data in a patient with drug resistant epilepsy during presurgical evaluation. We used dedicated insertion screws and optically insulated amplifiers. We recorded 137 SEEG contacts on 10 depth electrodes (5-15 contacts each) and 248 MEG channels (magnetometers). Signal quality was assessed by comparing the distribution of RMS values in different frequency bands to a reference set of MEG acquisitions. The quality of signals was excellent for both MEG and SEEG; for MEG, it was comparable to that of MEG signals without concurrent SEEG. Discharges involving several structures on SEEG were visible on MEG, whereas discharges limited in space were not seen at the surface. SEEG can now be recorded simultaneously with whole-head MEG in routine. This opens new avenues, both methodologically for understanding signals and improving signal processing methods, and clinically for future combined analyses.

Compressive sensing of signals generated in plastic scintillators in a novel J-PET instrument

NASA Astrophysics Data System (ADS)

Raczyński, L.; Moskal, P.; Kowalski, P.; Wiślicki, W.; Bednarski, T.; Białas, P.; Czerwiński, E.; Gajos, A.; Kapłon, Ł.; Kochanowski, A.; Korcyl, G.; Kowal, J.; Kozik, T.; Krzemień, W.; Kubicz, E.; Niedźwiecki, Sz.; Pałka, M.; Rudy, Z.; Rundel, O.; Salabura, P.; Sharma, N. G.; Silarski, M.; Słomski, A.; Smyrski, J.; Strzelecki, A.; Wieczorek, A.; Zieliński, M.; Zoń, N.

2015-06-01

The J-PET scanner, which allows for single bed imaging of the whole human body, is currently under development at the Jagiellonian University. The discussed detector offers improvement of the Time of Flight (TOF) resolution due to the use of fast plastic scintillators and dedicated electronics allowing for sampling in the voltage domain of signals with durations of few nanoseconds. In this paper we show that recovery of the whole signal, based on only a few samples, is possible. In order to do that, we incorporate the training signals into the Tikhonov regularization framework and we perform the Principal Component Analysis decomposition, which is well known for its compaction properties. The method yields a simple closed form analytical solution that does not require iterative processing. Moreover, from the Bayes theory the properties of regularized solution, especially its covariance matrix, may be easily derived. This is the key to introduce and prove the formula for calculations of the signal recovery error. In this paper we show that an average recovery error is approximately inversely proportional to the number of acquired samples.

Wnt signaling: Ig-norrin the dogma.

PubMed

Clevers, Hans

2004-06-08

Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome. Copyright 2004 Elsevier Ltd.

Blind detection of giant pulses: GPU implementation

NASA Astrophysics Data System (ADS)

Ait-Allal, Dalal; Weber, Rodolphe; Dumez-Viou, Cédric; Cognard, Ismael; Theureau, Gilles

2012-01-01

Radio astronomical pulsar observations require specific instrumentation and dedicated signal processing to cope with the dispersion caused by the interstellar medium. Moreover, the quality of observations can be limited by radio frequency interference (RFI) generated by Telecommunications activity. This article presents the innovative pulsar instrumentation based on graphical processing units (GPU) which has been designed at the Nançay Radio Astronomical Observatory. In addition, for giant pulsar search, we propose a new approach which combines a hardware-efficient search method and some RFI mitigation capabilities. Although this approach is less sensitive than the classical approach, its advantage is that no a priori information on the pulsar parameters is required. The validation of a GPU implementation is under way.

Electronic system for floor surface type detection in robotics applications

NASA Astrophysics Data System (ADS)

Tarapata, Grzegorz; Paczesny, Daniel; Tarasiuk, Łukasz

2016-11-01

The paper reports a recognizing method base on ultrasonic transducers utilized for the surface types detection. Ultra-sonic signal is transmitted toward the examined substrate, then reflected and scattered signal goes back to another ultra-sonic receiver. Thee measuring signal is generated by a piezo-electric transducer located at specified distance from the tested substrate. The detector is a second piezo-electric transducer located next to the transmitter. Depending on thee type of substrate which is exposed by an ultrasonic wave, the signal is partially absorbed inn the material, diffused and reflected towards the receiver. To measure the level of received signal, the dedicated electronic circuit was design and implemented in the presented systems. Such system was designed too recognize two types of floor surface: solid (like concrete, ceramic stiles, wood) and soft (carpets, floor coverings). The method will be applied in electronic detection system dedicated to autonomous cleaning robots due to selection of appropriate cleaning method. This work presents the concept of ultrasonic signals utilization, the design of both the measurement system and the measuring stand and as well number of wide tests results which validates correctness of applied ultrasonic method.

CHAM: weak signals detection through a new multivariate algorithm for process control

NASA Astrophysics Data System (ADS)

Bergeret, François; Soual, Carole; Le Gratiet, B.

2016-10-01

Derivatives technologies based on core CMOS processes are significantly aggressive in term of design rules and process control requirements. Process control plan is a derived from Process Assumption (PA) calculations which result in a design rule based on known process variability capabilities, taking into account enough margin to be safe not only for yield but especially for reliability. Even though process assumptions are calculated with a 4 sigma known process capability margin, efficient and competitive designs are challenging the process especially for derivatives technologies in 40 and 28nm nodes. For wafer fab process control, PA are declined in monovariate (layer1 CD, layer2 CD, layer2 to layer1 overlay, layer3 CD etc….) control charts with appropriated specifications and control limits which all together are securing the silicon. This is so far working fine but such system is not really sensitive to weak signals coming from interactions of multiple key parameters (high layer2 CD combined with high layer3 CD as an example). CHAM is a software using an advanced statistical algorithm specifically designed to detect small signals, especially when there are many parameters to control and when the parameters can interact to create yield issues. In this presentation we will first present the CHAM algorithm, then the case-study on critical dimensions, with the results, and we will conclude on future work. This partnership between Ippon and STM is part of E450LMDAP, European project dedicated to metrology and lithography development for future technology nodes, especially 10nm.

Estimation of continuous multi-DOF finger joint kinematics from surface EMG using a multi-output Gaussian Process.

PubMed

Ngeo, Jimson; Tamei, Tomoya; Shibata, Tomohiro

2014-01-01

Surface electromyographic (EMG) signals have often been used in estimating upper and lower limb dynamics and kinematics for the purpose of controlling robotic devices such as robot prosthesis and finger exoskeletons. However, in estimating multiple and a high number of degrees-of-freedom (DOF) kinematics from EMG, output DOFs are usually estimated independently. In this study, we estimate finger joint kinematics from EMG signals using a multi-output convolved Gaussian Process (Multi-output Full GP) that considers dependencies between outputs. We show that estimation of finger joints from muscle activation inputs can be improved by using a regression model that considers inherent coupling or correlation within the hand and finger joints. We also provide a comparison of estimation performance between different regression methods, such as Artificial Neural Networks (ANN) which is used by many of the related studies. We show that using a multi-output GP gives improved estimation compared to multi-output ANN and even dedicated or independent regression models.

Using multiplex-staining to study changes in the maize leaf phosphoproteome in response to mechanical wounding

USDA-ARS?s Scientific Manuscript database

Mechanical wounding of 2-week old maize (Zea mays L.) leaves, one of the first steps in both pathogen infection and herbivore attack, stimulates metabolism and activates signal transduction pathways dedicated to defense and recovery. The signaling pathways include reversible protein phosphorylation...

Bathymetry and composition of Titan's Ontario Lacus derived from Monte Carlo-based waveform inversion of Cassini RADAR altimetry data

NASA Astrophysics Data System (ADS)

Mastrogiuseppe, M.; Hayes, A. G.; Poggiali, V.; Lunine, J. I.; Lorenz, R. D.; Seu, R.; Le Gall, A.; Notarnicola, C.; Mitchell, K. L.; Malaska, M.; Birch, S. P. D.

2018-01-01

Recently, the Cassini RADAR was used to sound hydrocarbon lakes and seas on Saturn's moon Titan. Since the initial discovery of echoes from the seabed of Ligeia Mare, the second largest liquid body on Titan, a dedicated radar processing chain has been developed to retrieve liquid depth and microwave absorptivity information from RADAR altimetry of Titan's lakes and seas. Herein, we apply this processing chain to altimetry data acquired over southern Ontario Lacus during Titan fly-by T49 in December 2008. The new signal processing chain adopts super resolution techniques and dedicated taper functions to reveal the presence of reflection from Ontario's lakebed. Unfortunately, the extracted waveforms from T49 are often distorted due to signal saturation, owing to the extraordinarily strong specular reflections from the smooth lake surface. This distortion is a function of the saturation level and can introduce artifacts, such as signal precursors, which complicate data interpretation. We use a radar altimetry simulator to retrieve information from the saturated bursts and determine the liquid depth and loss tangent of Ontario Lacus. Received waveforms are represented using a two-layer model, where Cassini raw radar data are simulated in order to reproduce the effects of receiver saturation. A Monte Carlo based approach along with a simulated waveform look-up table is used to retrieve parameters that are given as inputs to a parametric model which constrains radio absorption of Ontario Lacus and retrieves information about the dielectric properties of the liquid. We retrieve a maximum depth of 50 m along the radar transect and a best-fit specific attenuation of the liquid equal to 0.2 ± 0.09 dB m-1 that, when converted into loss tangent, gives tanδ = 7 ± 3 × 10-5. When combined with laboratory measured cryogenic liquid alkane dielectric properties and the variable solubility of nitrogen in ethane-methane mixtures, the best-fit loss tangent is consistent with a ternary mixture of 51% methane, 38% ethane and 11% nitrogen by volume.

Conception et realisation d'un echantillonneur de grande vitesse en technologie HIGFET (transistor a effet de champ avec heterostructure et grille isolee)

NASA Astrophysics Data System (ADS)

Tazlauanu, Mihai

The research work reported in this thesis details a new fabrication technology for high speed integrated circuits in the broadest sense, including original contributions to device modeling, circuit simulation, integrated circuit design, wafer fabrication, micro-physical and electrical characterization, process flow and final device testing as part of an electrical system. The primary building block of this technology is the heterostructure insulated gate field effect transistor, HIGFET. We used an InP/InGaAs epitaxial heterostructure to ensure a high charge carrier mobility and hence obtain a higher operating frequency than that currently possible for silicon devices. We designed and built integrated circuits with two system architectures. The first architecture integrates the clock signal generator with the sample and hold circuitry on the InP die, while the second is a hybrid architecture of an InP sample and hold assembled with an external clock signal generator made with ECL circuits on GaAs. To generate the clock signals on the same die with the sample and hold circuits, we developed a digital circuit family based on an original inverter, appropriate for depletion mode NMOS technology. We used this circuit to design buffer amplifiers and ring oscillators. Four mask sets produced in a Cadence environment, have permitted the fabrication of test and working devices. Each new mask generation has reflected the previous achievements and has implemented new structures and circuit techniques. The fabrication technology has undergone successive modifications and refinements to optimize device manufacturing. Particular attention has been paid to the technological robustness. The plasma enhanced etching process (RIE) had been used for an exhaustive study for the statistical simulation of the technological steps. Electrical measurements, performed on the experimental samples, have permitted the modeling of the devices, technological processing to be adjusted and circuit design improved. Electrical measurements performed on dedicated test structures, during the fabrication cycle, allowed the identification and correction of some technological problems (ohmic contacts, current leakage, interconnection integrity, and thermal instabilities). Feedback corrections were validated by dedicated experiments with the experimental effort optimized by statistical techniques (factorial fractional design). (Abstract shortened by UMI.)

Stereomotion is processed by the third-order motion system: reply to comment on Three-systems theory of human visual motion perception: review and update

NASA Astrophysics Data System (ADS)

Lu, Zhong-Lin; Sperling, George

2002-10-01

Two theories are considered to account for the perception of motion of depth-defined objects in random-dot stereograms (stereomotion). In the LuSperling three-motion-systems theory J. Opt. Soc. Am. A 18 , 2331 (2001), stereomotion is perceived by the third-order motion system, which detects the motion of areas defined as figure (versus ground) in a salience map. Alternatively, in his comment J. Opt. Soc. Am. A 19 , 2142 (2002), Patterson proposes a low-level motion-energy system dedicated to stereo depth. The critical difference between these theories is the preprocessing (figureground based on depth and other cues versus simply stereo depth) rather than the motion-detection algorithm itself (because the motion-extraction algorithm for third-order motion is undetermined). Furthermore, the ability of observers to perceive motion in alternating feature displays in which stereo depth alternates with other features such as texture orientation indicates that the third-order motion system can perceive stereomotion. This reduces the stereomotion question to Is it third-order alone or third-order plus dedicated depth-motion processing? Two new experiments intended to support the dedicated depth-motion processing theory are shown here to be perfectly accounted for by third-order motion, as are many older experiments that have previously been shown to be consistent with third-order motion. Cyclopean and rivalry images are shown to be a likely confound in stereomotion studies, rivalry motion being as strong as stereomotion. The phase dependence of superimposed same-direction stereomotion stimuli, rivalry stimuli, and isoluminant color stimuli indicates that these stimuli are processed in the same (third-order) motion system. The phase-dependence paradigm Lu and Sperling, Vision Res. 35 , 2697 (1995) ultimately can resolve the question of which types of signals share a single motion detector. All the evidence accumulated so far is consistent with the three-motion-systems theory. 2002 Optical Society of America

Development of dual sensor hand-held detector

NASA Astrophysics Data System (ADS)

Sezgin, Mehmet

2010-04-01

In this paper hand-held dual sensor detector development requirements are considered dedicated to buried object detection. Design characteristics of such a system are categorized and listed. Hardware and software structures, ergonomics, user interface, environmental and EMC/EMI tests to be applied and performance test issues are studied. Main properties of the developed system (SEZER) are presented, which contains Metal Detector (MD) and Ground Penetrating Radar (GPR). The realized system has ergonomic structure and can detect both metallic and non-metallic buried objects. Moreover classification of target is possible if it was defined to the signal processing software in learning phase.

The Expanded Owens Valley Solar Array

NASA Astrophysics Data System (ADS)

Gary, Dale E.; Hurford, G. J.; Nita, G. M.; White, S. M.; Tun, S. D.; Fleishman, G. D.; McTiernan, J. M.

2011-05-01

The Expanded Owens Valley Solar Array (EOVSA) is now under construction near Big Pine, CA as a solar-dedicated microwave imaging array operating in the frequency range 1-18 GHz. The solar science to be addressed focuses on the 3D structure of the solar corona (magnetic field, temperature and density), on the sudden release of energy and subsequent particle acceleration, transport and heating, and on space weather phenomena. The project will support the scientific community by providing open data access and software tools for analysis of the data, to exploit synergies with on-going solar research in other wavelengths. The New Jersey Institute of Technology (NJIT) is expanding OVSA from its previous complement of 7 antennas to a total of 15 by adding 8 new antennas, and will reinvest in the existing infrastructure by replacing the existing control systems, signal transmission, and signal processing with modern, far more capable and reliable systems based on new technology developed for the Frequency Agile Solar Radiotelescope (FASR). The project will be completed in time to provide solar-dedicated observations during the upcoming solar maximum in 2013 and beyond. We provide an update on current status and our preparations for exploiting the data through modeling and data analysis tools. This research is supported by NSF grants AST-0908344, and AGS-0961867 and NASA grant NNX10AF27G to New Jersey Institute of Technology.

Natural and Heterologous Production of Bacteriocins

NASA Astrophysics Data System (ADS)

Cintas, Luis M.; Herranz, Carmen; Hernández, Pablo E.

Bacteriocins are ribosomally synthesized antimicrobial peptides produced by bacteria, and their use as natural and nontoxic food preservatives has been the source of considerable interest for the research community. In addition, bacteriocins have been investigated for their potential use in human and veterinary applications and in the animal production field. In the native bacterial strain, most bacteriocins are synthesized as biologically inactive precursors, with N-terminal extensions, that are cleaved concomitantly during export of the bacteriocin by dedicated ABC transporters, or the general secretory pathway (GSP) or Sec-dependent pathway. However, a few bacteriocins are synthesized without an N-terminal extension, and others are circularized through a head-to-tail peptide bond, complicating the elucidation of their processing and transport across the cytoplasmic membrane. The high cost of synthetic bacteriocin synthesis and their low yields from many natural producers recommends the exploration of recombinant microbial systems for the heterologous production of bacteriocins. Other advantages of such systems include production of bacteriocins in safer hosts, increased bacteriocin production, control of bacteriocin gene expression, production of food ingredients with antimicrobial activity, construction of multibacteriocinogenic strains with a wider antagonistic spectrum, a better adaptation of the selected hosts to food environments, and providing antagonistic properties to lactic acid bacteria (LAB) used as starter, protective, or probiotic cultures. The recombinant production of bacteriocins mostly relies on the use of expression vectors that replicate in Gram-negative bacteria, Gram-positive bacteria, and yeasts, whereas the production of bacteriocins in heterologous LAB hosts may be essentially based on the expression of native biosynthetic genes, by exchanging or replacing leader peptides and/or dedicated processing and secretion systems (ABC transporters), or by fusion of mature bacteriocins to signal peptides that act as secretion signals.

Commissioning of an integrated platform for time-resolved treatment delivery in scanned ion beam therapy by means of optical motion monitoring.

PubMed

Fattori, G; Saito, N; Seregni, M; Kaderka, R; Pella, A; Constantinescu, A; Riboldi, M; Steidl, P; Cerveri, P; Bert, C; Durante, M; Baroni, G

2014-12-01

The integrated use of optical technologies for patient monitoring is addressed in the framework of time-resolved treatment delivery for scanned ion beam therapy. A software application has been designed to provide the therapy control system (TCS) with a continuous geometrical feedback by processing the external surrogates tridimensional data, detected in real-time via optical tracking. Conventional procedures for phase-based respiratory phase detection were implemented, as well as the interface to patient specific correlation models, in order to estimate internal tumor motion from surface markers. In this paper, particular attention is dedicated to the quantification of time delays resulting from system integration and its compensation by means of polynomial interpolation in the time domain. Dedicated tests to assess the separate delay contributions due to optical signal processing, digital data transfer to the TCS and passive beam energy modulation actuation have been performed. We report the system technological commissioning activities reporting dose distribution errors in a phantom study, where the treatment of a lung lesion was simulated, with both lateral and range beam position compensation. The zero-delay systems integration with a specific active scanning delivery machine was achieved by tuning the amount of time prediction applied to lateral (14.61 ± 0.98 ms) and depth (34.1 ± 6.29 ms) beam position correction signals, featuring sub-millimeter accuracy in forward estimation. Direct optical target observation and motion phase (MPh) based tumor motion discretization strategies were tested, resulting in 20.3(2.3)% and 21.2(9.3)% median (IQR) percentual relative dose difference with respect to static irradiation, respectively. Results confirm the technical feasibility of the implemented strategy towards 4D treatment delivery, with negligible percentual dose deviations with respect to static irradiation.

Differences in electrosensory anatomy and social behavior in an area of sympatry between two species of mormyrid electric fishes.

PubMed

Carlson, Bruce A

2016-01-01

Sensory systems play a key role in social behavior by mediating the detection and analysis of communication signals. In mormyrid fishes, electric signals are processed within a dedicated sensory pathway, providing a unique opportunity to relate sensory biology to social behavior. Evolutionary changes within this pathway led to new perceptual abilities that have been linked to increased rates of signal evolution and species diversification in a lineage called 'clade A'. Previous field observations suggest that clade-A species tend to be solitary and territorial, whereas non-clade-A species tend to be clustered in high densities suggestive of schooling or shoaling. To explore behavioral differences between species in these lineages in greater detail, I studied population densities, social interactions, and electric signaling in two mormyrid species, Gnathonemus victoriae (clade A) and Petrocephalus degeni (non-clade A), from Lwamunda Swamp, Uganda. Petrocephalus degeni was found at higher population densities, but intraspecific diversity in electric signal waveform was greater in G. victoriae. In the laboratory, G. victoriae exhibited strong shelter-seeking behavior and competition for shelter, whereas P. degeni were more likely to abandon shelter in the presence of conspecifics as well as electric mimics of signaling conspecifics. In other words, P. degeni exhibited social affiliation whereas G. victoriae exhibited social competition. Further, P. degeni showed correlated electric signaling behavior whereas G. victoriae showed anti-correlated signaling behavior. These findings extend previous reports of social spacing, territoriality, and habitat preference among mormyrid species, suggesting that evolutionary divergence in electrosensory processing relates to differences in social behavior. © 2016. Published by The Company of Biologists Ltd.

Sensorimotor Integration for Decision Making: How the Worm Steers.

PubMed

Kaplan, Harris S; Zimmer, Manuel

2018-01-17

Animals' movements actively shape their perception and subsequent decision making. In this issue of Neuron, Liu et al. (2018) show how C. elegans nematodes steer toward an odorant: a dedicated interneuron class integrates oscillatory olfactory signals, generated by head swings, with corollary discharge motor signals. Copyright © 2017 Elsevier Inc. All rights reserved.

Plantar fascia evaluation with a dedicated magnetic resonance scanner in weight-bearing position: our experience in patients with plantar fasciitis and in healthy volunteers.

PubMed

Sutera, R; Iovane, A; Sorrentino, F; Candela, F; Mularo, V; La Tona, G; Midiri, M

2010-03-01

This study assessed the usefulness of upright weight-bearing examination of the ankle/hind foot performed with a dedicated magnetic resonance (MR) imaging scanner in the evaluation of the plantar fascia in healthy volunteers and in patients with clinical evidence of plantar fasciitis. Between January and March 2009, 20 patients with clinical evidence of plantar fasciitis (group A) and a similar number of healthy volunteers (group B) underwent MR imaging of the ankle/hind foot in the upright weight-bearing and conventional supine position. A 0.25-Tesla MR scanner (G-Scan, Esaote SpA, Genoa, Italy) was used with a dedicated receiving coil for the ankle/hind foot. Three radiologists, blinded to patients' history and clinical findings, assessed in consensus morphological and dimensional changes and signal intensity alterations on images acquired in both positions, in different sequences and in different planes. In group A, MR imaging confirmed the diagnosis in 15/20 cases; in 4/15 cases, a partial tear of the plantar fascia was identified in the upright weight-bearing position alone. In the remaining 5/20 cases in group A and in all cases in group B, the plantar fascia showed no abnormal signal intensity. Because of the increased stretching of the plantar fascia, in all cases in group A and B, thickness in the proximal third was significantly reduced (p<0.0001) under upright weight-bearing compared with the supine position. Imaging the ankle/hind foot in the upright weight-bearing position with a dedicated MR scanner and a dedicated coil might enable the identification of partial tears of the plantar fascia, which could be overlooked in the supine position.

NASA-SETI microwave observing project: Targeted Search Element (TSE)

NASA Technical Reports Server (NTRS)

Webster, L. D.

1991-01-01

The Targeted Search Element (TSE) performs one of two complimentary search strategies of the NASA-SETI Microwave Observing Project (MOP): the targeted search. The principle objective of the targeted search strategy is to scan the microwave window between the frequencies of one and three gigahertz for narrowband microwave emissions eminating from the direction of 773 specifically targeted stars. The scanning process is accomplished at a minimum resolution of one or two Hertz at very high sensitivity. Detectable signals will be of a continuous wave or pulsed form and may also drift in frequency. The TSE will possess extensive radio frequency interference (RFI) mitigation and verification capability as the majority of signals detected by the TSE will be of local origin. Any signal passing through RFI classification and classifiable as an extraterrestrial intelligence (ETI) candidate will be further validated at non-MOP observatories using established protocol. The targeted search will be conducted using the capability provided by the TSE. The TSE provides six Targeted Search Systems (TSS) which independently or cooperatively perform automated collection, analysis, storage, and archive of signal data. Data is collected in 10 megahertz chunks and signal processing is performed at a rate of 160 megabits per second. Signal data is obtained utilizing the largest radio telescopes available for the Targeted Search such as those at Arecibo and Nancay or at the dedicated NASA-SETI facility. This latter facility will allow continuous collection of data. The TSE also provides for TSS utilization planning, logistics, remote operation, and for off-line data analysis and permanent archive of both the Targeted Search and Sky Survey data.

Compensation for the signal processing characteristics of ultrasound B-mode scanners in adaptive speckle reduction.

PubMed

Crawford, D C; Bell, D S; Bamber, J C

1993-01-01

A systematic method to compensate for nonlinear amplification of individual ultrasound B-scanners has been investigated in order to optimise performance of an adaptive speckle reduction (ASR) filter for a wide range of clinical ultrasonic imaging equipment. Three potential methods have been investigated: (1) a method involving an appropriate selection of the speckle recognition feature was successful when the scanner signal processing executes simple logarithmic compressions; (2) an inverse transform (decompression) of the B-mode image was effective in correcting for the measured characteristics of image data compression when the algorithm was implemented in full floating point arithmetic; (3) characterising the behaviour of the statistical speckle recognition feature under conditions of speckle noise was found to be the method of choice for implementation of the adaptive speckle reduction algorithm in limited precision integer arithmetic. In this example, the statistical features of variance and mean were investigated. The third method may be implemented on commercially available fast image processing hardware and is also better suited for transfer into dedicated hardware to facilitate real-time adaptive speckle reduction. A systematic method is described for obtaining ASR calibration data from B-mode images of a speckle producing phantom.

Practical considerations of image analysis and quantification of signal transduction IHC staining.

PubMed

Grunkin, Michael; Raundahl, Jakob; Foged, Niels T

2011-01-01

The dramatic increase in computer processing power in combination with the availability of high-quality digital cameras during the last 10 years has fertilized the grounds for quantitative microscopy based on digital image analysis. With the present introduction of robust scanners for whole slide imaging in both research and routine, the benefits of automation and objectivity in the analysis of tissue sections will be even more obvious. For in situ studies of signal transduction, the combination of tissue microarrays, immunohistochemistry, digital imaging, and quantitative image analysis will be central operations. However, immunohistochemistry is a multistep procedure including a lot of technical pitfalls leading to intra- and interlaboratory variability of its outcome. The resulting variations in staining intensity and disruption of original morphology are an extra challenge for the image analysis software, which therefore preferably should be dedicated to the detection and quantification of histomorphometrical end points.

The 21 cm signal and the interplay between dark matter annihilations and astrophysical processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lopez-Honorez, Laura; Mena, Olga; Moliné, Ángeles

2016-08-01

Future dedicated radio interferometers, including HERA and SKA, are very promising tools that aim to study the epoch of reionization and beyond via measurements of the 21 cm signal from neutral hydrogen. Dark matter (DM) annihilations into charged particles change the thermal history of the Universe and, as a consequence, affect the 21 cm signal. Accurately predicting the effect of DM strongly relies on the modeling of annihilations inside halos. In this work, we use up-to-date computations of the energy deposition rates by the products from DM annihilations, a proper treatment of the contribution from DM annihilations in halos, asmore » well as values of the annihilation cross section allowed by the most recent cosmological measurements from the Planck satellite. Given current uncertainties on the description of the astrophysical processes driving the epochs of reionization, X-ray heating and Lyman-α pumping, we find that disentangling DM signatures from purely astrophysical effects, related to early-time star formation processes or late-time galaxy X-ray emissions, will be a challenging task. We conclude that only annihilations of DM particles with masses of ∼100 MeV, could leave an unambiguous imprint on the 21 cm signal and, in particular, on the 21 cm power spectrum. This is in contrast to previous, more optimistic results in the literature, which have claimed that strong signatures might also be present even for much higher DM masses. Additional measurements of the 21 cm signal at different cosmic epochs will be crucial in order to break the strong parameter degeneracies between DM annihilations and astrophysical effects and undoubtedly single out a DM imprint for masses different from ∼100 MeV.« less

Data Acquisition System for Silicon Ultra Fast Cameras for Electron and Gamma Sources in Medical Applications (sucima Imager)

NASA Astrophysics Data System (ADS)

Czermak, A.; Zalewska, A.; Dulny, B.; Sowicki, B.; Jastrząb, M.; Nowak, L.

2004-07-01

The needs for real time monitoring of the hadrontherapy beam intensity and profile as well as requirements for the fast dosimetry using Monolithic Active Pixel Sensors (MAPS) forced the SUCIMA collaboration to the design of the unique Data Acquisition System (DAQ SUCIMA Imager). The DAQ system has been developed on one of the most advanced XILINX Field Programmable Gate Array chip - VERTEX II. The dedicated multifunctional electronic board for the detector's analogue signals capture, their parallel digital processing and final data compression as well as transmission through the high speed USB 2.0 port has been prototyped and tested.

Photodarkening kinetics in a high-power YDFA versus CW or short-pulse seed conditions

NASA Astrophysics Data System (ADS)

Jolly, Alain; Vinçont, Cyril; Boullet, Johan

2017-02-01

We propose an innovating model to describe the kinetics of competing photo-darkening and photo-bleaching phenomena in high-power, Ytterbium-Doped-Fibre-Amplifiers. This model makes use of aggregated species of trivalent Ytterbium and divalent ions, which operate as primarily efficient color-centers. This ensures multi-photon excitation, partly from the pump and partly from the signal. The fit of numerical computations with dedicated experiments help to validate our theoretical assumptions, in the definition of the involved physics. Potential applications of this study include further discussions for the selection of processing options with fibre-manufacturers and the optimization of operating conditions.

Plasma membrane-associated platforms: dynamic scaffolds that organize membrane-associated events.

PubMed

Astro, Veronica; de Curtis, Ivan

2015-03-10

Specialized regions of the plasma membrane dedicated to diverse cellular processes, such as vesicle exocytosis, extracellular matrix remodeling, and cell migration, share a few cytosolic scaffold proteins that associate to form large plasma membrane-associated platforms (PMAPs). PMAPs organize signaling events and trafficking of membranes and molecules at specific membrane domains. On the basis of the intrinsic disorder of the proteins constituting the core of these PMAPs and of the dynamics of these structures at the periphery of motile cells, we propose a working model for the assembly and turnover of these platforms. Copyright © 2015, American Association for the Advancement of Science.

Wavelets and their applications past and future

NASA Astrophysics Data System (ADS)

Coifman, Ronald R.

2009-04-01

As this is a conference on mathematical tools for defense, I would like to dedicate this talk to the memory of Louis Auslander, who through his insights and visionary leadership, brought powerful new mathematics into DARPA, he has provided the main impetus to the development and insertion of wavelet based processing in defense. My goal here is to describe the evolution of a stream of ideas in Harmonic Analysis, ideas which in the past have been mostly applied for the analysis and extraction of information from physical data, and which now are increasingly applied to organize and extract information and knowledge from any set of digital documents, from text to music to questionnaires. This form of signal processing on digital data, is part of the future of wavelet analysis.

Infrared sensor for hot spot recognition for a small satellite mission

NASA Astrophysics Data System (ADS)

Skrbek, W.; Bachmann, K.; Lorenz, E.; Neidhardt, M.; Peschel, M.; Walter, I.; Zender, B.

1996-11-01

High temperature events strongly influence the environmental processes. Therefore, their observation is an important constituent of the global monitoring network. Unfortunately the current remote sensing systems are not able to deliver the necessary information about the world wide burn out of vegetation and its consequences. For global observations a dedicated system of small satellites is required. The main components of the corresponding instrumentation are the infrared channels. The proposed HSRS (HOT SPOT RECOGNITION SENSOR) has to demonstrate the possibilities of an such instrumentation and its feasibility for small satellites. The main drawbacks of the HSRS design are the handling of the hot spot recognition in the subpixel area and of the saturation in the case of larger hot areas by a suitable signal processing hardware.

Damage signals in the insect immune response

PubMed Central

Krautz, Robert; Arefin, Badrul; Theopold, Ulrich

2014-01-01

Insects and mammals share an ancient innate immune system comprising both humoral and cellular responses. The insect immune system consists of the fat body, which secretes effector molecules into the hemolymph and several classes of hemocytes, which reside in the hemolymph and of protective border epithelia. Key features of wound- and immune responses are shared between insect and mammalian immune systems including the mode of activation by commonly shared microbial (non-self) patterns and the recognition of these patterns by dedicated receptors. It is unclear how metazoan parasites in insects, which lack these shared motifs, are recognized. Research in recent years has demonstrated that during entry into the insect host, many eukaryotic pathogens leave traces that alert potential hosts of the damage they have afflicted. In accordance with terminology used in the mammalian immune systems, these signals have been dubbed danger- or damage-associated signals. Damage signals are necessary byproducts generated during entering hosts either by mechanical or proteolytic damage. Here, we briefly review the current stage of knowledge on how wound closure and wound healing during mechanical damage is regulated and how damage-related signals contribute to these processes. We also discuss how sensors of proteolytic activity induce insect innate immune responses. Strikingly damage-associated signals are also released from cells that have aberrant growth, including tumor cells. These signals may induce apoptosis in the damaged cells, the recruitment of immune cells to the aberrant tissue and even activate humoral responses. Thus, this ensures the removal of aberrant cells and compensatory proliferation to replace lost tissue. Several of these pathways may have been co-opted from wound healing and developmental processes. PMID:25071815

A setup for combined multiphoton laser scanning microscopic and multi-electrode patch clamp experiments on brain slices

NASA Astrophysics Data System (ADS)

Helm, P. Johannes; Reppen, Trond; Heggelund, Paul

2009-02-01

Multi Photon Laser Scanning Microscopy (MPLSM) appears today as one of the most powerful experimental tools in cellular neurophysiology, notably in studies of the functional dynamics of signal processing in single neurons. Simultaneous recording of fluorescence signals at high spatial and temporal resolution and electric signals by means of multi electrode patch clamp techniques have provided new paths for the systematic investigation of neuronal mechanisms. In particular, this approach has opened for direct studies of dendritic signal processing in neurons. We report about a setup optimized for simultaneous electrophysiological multi electrode patch clamp and multi photon laser scanning fluorescence microscopic experiments on brain slices. The microscopic system is based on a modified commercially available confocal scanning laser microscope (CLSM). From a technical and operational point of view, two developments are important: Firstly, in order to reduce the workload for the experimentalist, who in general is forced to concentrate on controlling the electrophysiological parameters during the recordings, a system of shutters has been installed together with dedicated electronic modules protecting the photo detectors against destructive light levels caused by erroneous opening or closing of microscopic light paths by the experimentalist. Secondly, the standard detection unit has been improved by installing the photomultiplier tubes (PMT) in a Peltier cooled thermal box shielding the detector from both room temperature and distortions caused by external electromagnetic fields. The electrophysiological system is based on an industrial standard multi patch clamp unit ergonomically arranged around the microscope stage. The electrophysiological and scanning processes can be time coordinated by standard trigger electronics.

Organization of the Drosophila larval visual circuit

PubMed Central

Gendre, Nanae; Neagu-Maier, G Larisa; Fetter, Richard D; Schneider-Mizell, Casey M; Truman, James W; Zlatic, Marta; Cardona, Albert

2017-01-01

Visual systems transduce, process and transmit light-dependent environmental cues. Computation of visual features depends on photoreceptor neuron types (PR) present, organization of the eye and wiring of the underlying neural circuit. Here, we describe the circuit architecture of the visual system of Drosophila larvae by mapping the synaptic wiring diagram and neurotransmitters. By contacting different targets, the two larval PR-subtypes create two converging pathways potentially underlying the computation of ambient light intensity and temporal light changes already within this first visual processing center. Locally processed visual information then signals via dedicated projection interneurons to higher brain areas including the lateral horn and mushroom body. The stratified structure of the larval optic neuropil (LON) suggests common organizational principles with the adult fly and vertebrate visual systems. The complete synaptic wiring diagram of the LON paves the way to understanding how circuits with reduced numerical complexity control wide ranges of behaviors.

In-situ measurement of concentrated solar flux and distribution at the aperture of a central solar receiver

NASA Astrophysics Data System (ADS)

Ferriere, Alain; Volut, Mikael; Perez, Antoine; Volut, Yann

2016-05-01

A flux mapping system has been designed, implemented and experimented at the top of the Themis solar tower in France. This system features a moving bar associated to a CCD video camera and a flux gauge mounted onto the bar used as reference measurement for calibration purpose. Images and flux signal are acquired separately. The paper describes the equipment and focus on the data processing to issue the distribution of flux density and concentration at the aperture of the solar receiver. Finally, the solar power entering into the receiver is estimated by integration of flux density. The processing is largely automated in the form of a dedicated software with fast execution. A special attention is paid to the accuracy of the results, to the robustness of the algorithm and to the velocity of the processing.

High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications.

PubMed

Tivnan, Matthew; Gurjar, Rajan; Wolf, David E; Vishwanath, Karthik

2015-08-12

Diffuse Correlation Spectroscopy (DCS) is a well-established optical technique that has been used for non-invasive measurement of blood flow in tissues. Instrumentation for DCS includes a correlation device that computes the temporal intensity autocorrelation of a coherent laser source after it has undergone diffuse scattering through a turbid medium. Typically, the signal acquisition and its autocorrelation are performed by a correlation board. These boards have dedicated hardware to acquire and compute intensity autocorrelations of rapidly varying input signal and usually are quite expensive. Here we show that a Raspberry Pi minicomputer can acquire and store a rapidly varying time-signal with high fidelity. We show that this signal collected by a Raspberry Pi device can be processed numerically to yield intensity autocorrelations well suited for DCS applications. DCS measurements made using the Raspberry Pi device were compared to those acquired using a commercial hardware autocorrelation board to investigate the stability, performance, and accuracy of the data acquired in controlled experiments. This paper represents a first step toward lowering the instrumentation cost of a DCS system and may offer the potential to make DCS become more widely used in biomedical applications.

High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications

PubMed Central

Tivnan, Matthew; Gurjar, Rajan; Wolf, David E.; Vishwanath, Karthik

2015-01-01

Diffuse Correlation Spectroscopy (DCS) is a well-established optical technique that has been used for non-invasive measurement of blood flow in tissues. Instrumentation for DCS includes a correlation device that computes the temporal intensity autocorrelation of a coherent laser source after it has undergone diffuse scattering through a turbid medium. Typically, the signal acquisition and its autocorrelation are performed by a correlation board. These boards have dedicated hardware to acquire and compute intensity autocorrelations of rapidly varying input signal and usually are quite expensive. Here we show that a Raspberry Pi minicomputer can acquire and store a rapidly varying time-signal with high fidelity. We show that this signal collected by a Raspberry Pi device can be processed numerically to yield intensity autocorrelations well suited for DCS applications. DCS measurements made using the Raspberry Pi device were compared to those acquired using a commercial hardware autocorrelation board to investigate the stability, performance, and accuracy of the data acquired in controlled experiments. This paper represents a first step toward lowering the instrumentation cost of a DCS system and may offer the potential to make DCS become more widely used in biomedical applications. PMID:26274961

A novel digital pulse processing architecture for nuclear instrumentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moline, Yoann; Thevenin, Mathieu; Corre, Gwenole

The field of nuclear instrumentation covers a wide range of applications, including counting, spectrometry, pulse shape discrimination and multi-channel coincidence. These applications are the topic of many researches, new algorithms and implementations are constantly proposed thanks to advances in digital signal processing. However, these improvements are not yet implemented in instrumentation devices. This is especially true for neutron-gamma discrimination applications which traditionally use charge comparison method while literature proposes other algorithms based on frequency domain or wavelet theory which show better performances. Another example is pileups which are generally rejected while pileup correction algorithms also exist. These processes are traditionallymore » performed offline due to two issues. The first is the Poissonian characteristic of the signal, composed of random arrival pulses which requires to current architectures to work in data flow. The second is the real-time requirement, which implies losing pulses when the pulse rate is too high. Despite the possibility of treating the pulses independently from each other, current architectures paralyze the acquisition of the signal during the processing of a pulse. This loss is called dead-time. These two issues have led current architectures to use dedicated solutions based on re-configurable components like Field Programmable Gate Arrays (FPGAs) to overcome the need of performance necessary to deal with dead-time. However, dedicated hardware algorithm implementations on re-configurable technologies are complex and time-consuming. For all these reasons, a programmable Digital pulse Processing (DPP) architecture in a high level language such as Cor C++ which can reduce dead-time would be worthwhile for nuclear instrumentation. This would reduce prototyping and test duration by reducing the level of hardware expertise to implement new algorithms. However, today's programmable solutions do not meet the need of performance to operate online and not allow scaling with the increase in the number of measurement channel. That is why an innovative DPP architecture is proposed in this paper. This architecture is able to overcome dead-time while being programmable and is flexible with the number of measurement channel. Proposed architecture is based on an innovative execution model for pulse processing applications which can be summarized as follow. The signal is not composed of pulses only, consequently, pulses processing does not have to operate on the entire signal. Therefore, the first step of our proposal is pulse extraction by the use of dedicated components named pulse extractors. The triggering step can be achieved after the analog-to-digital conversion without any signal shaping or filtering stages. Pileup detection and accurate pulse time stamping are done at this stage. Any application downstream this step can work on adaptive variable-sized array of samples simplifying pulse processing methods. Then, once the data flow is broken, it is possible to distribute pulses on Functional Units (FUs) which perform processing. As the date of each pulse is known, they can be processed individually out-of-order to provide the results. To manage the pulses distribution, a scheduler and an interconnection network are used. pulses are distributed on the first FU which is not busy without congesting the interconnection network. For this reason, the process duration does not result anymore in dead-time if there are enough FUs. FUs are designed to be standalone and to comprises at least a programmable general purpose processor (ARM, Microblaze) allowing the implementation of complex algorithms without any modification of the hardware. An acquisition chain is composed of a succession of algorithms which lead to organize our FUs as a software macro-pipeline, A simple approach consists in assigning one algorithm per FU. Consequently, the global latency becomes the worst latency of algorithms execution on FU. Moreover, as algorithms are executed locally - i.e. on a FU - this approach limits shared memory requirement. To handle multichannel, we propose FUs sharing, this approach maximize the chance to find a non-busy FU to process an incoming pulse. This is possible since each channel receive random event independently, the pulse extractors associated to them do not necessarily need to access simultaneously to all Computing resources at the same time to distribute their pulses. The major contribution of this paper is the proposition of an execution model and its associated hardware programmable architecture for digital pulse processing that can handle multiple acquisition channels while maintaining the scalability thanks to the use of shared resources. This execution model and associated architecture are validated by simulation of a cycle accurate architecture SystemC model. Proposed architecture shows promising results in terms of scalability while maintaining zero dead-time. This work also permit the sizing of hardware resources requirement required for a predefined set of applications. Future work will focus on the interconnection network and a scheduling policy that can exploit the variable-length of pulses. Then, the hardware implementation of this architecture will be performed and tested for a representative set of application.« less

A three channel telemetry system

NASA Technical Reports Server (NTRS)

Lesho, Jeffery C.; Eaton, Harry A. C.

1993-01-01

A three channel telemetry system intended for biomedical applications is described. The transmitter is implemented in a single chip using a 2 micron BiCMOS processes. The operation of the system and the test results from the latest chip are discussed. One channel is always dedicated to temperature measurement while the other two channels are generic. The generic channels carry information from transducers that are interfaced to the system through on-chip general purpose operational amplifiers. The generic channels have different bandwidths: one from dc to 250 Hz and the other from dc to 1300 Hz. Each generic channel modulates a current controlled oscillator to produce a frequency modulated signal. The two frequency modulated signals are summed and used to amplitude modulate the temperature signal which acts as a carrier. A near-field inductive link telemeters the combined signals over a short distance. The chip operates on a supply voltage anywhere from 2.5 to 3.6 Volts and draws less than 1 mA when transmitting a signal. The chip can be incorporated into ingestible, implantable and other configurations. The device can free the patient from tethered data collection systems and reduces the possibility of infection from subcutaneous leads. Data telemetry can increase patient comfort leading to a greater acceptance of monitoring.

Comparing student clinical self-efficacy and team process outcomes for a DEU, blended, and traditional clinical setting: A quasi-experimental research study.

PubMed

Plemmons, Christina; Clark, Michele; Feng, Du

2018-03-01

Clinical education is vital to both the development of clinical self-efficacy and the integration of future nurses into health care teams. The dedicated education unit clinical teaching model is an innovative clinical partnership, which promotes skill development, professional growth, clinical self-efficacy, and integration as a team member. Blended clinical teaching models are combining features of the dedicated education unit and traditional clinical model. The aims of this study are to explore how each of three clinical teaching models (dedicated education unit, blended, traditional) affects clinical self-efficacy and attitude toward team process, and to compare the dedicated education unit model and blended model to traditional clinical. A nonequivalent control-group quasi-experimental design was utilized. The convenience sample of 272 entry-level baccalaureate nursing students included 84 students participating in a dedicated education unit model treatment group, 66 students participating in a blended model treatment group, and 122 students participating in a traditional model control group. Perceived clinical self-efficacy was evaluated by the pretest/posttest scores obtained on the General Self-Efficacy scale. Attitude toward team process was evaluated by the pretest/posttest scores obtained on the TeamSTEPPS® Teamwork Attitude Questionnaire. All three clinical teaching models resulted in significant increases in both clinical self-efficacy (p=0.04) and attitude toward team process (p=0.003). Students participating in the dedicated education unit model (p=0.016) and students participating in the blended model (p<0.001) had significantly larger increases in clinical self-efficacy compared to students participating in the traditional model. These findings support the use of dedicated education unit and blended clinical partnerships as effective alternatives to the traditional model to promote both clinical self-efficacy and team process among entry-level baccalaureate nursing students. Copyright © 2017 Elsevier Ltd. All rights reserved.

THOR Fields and Wave Processor - FWP

NASA Astrophysics Data System (ADS)

Soucek, Jan; Rothkaehl, Hanna; Ahlen, Lennart; Balikhin, Michael; Carr, Christopher; Dekkali, Moustapha; Khotyaintsev, Yuri; Lan, Radek; Magnes, Werner; Morawski, Marek; Nakamura, Rumi; Uhlir, Ludek; Yearby, Keith; Winkler, Marek; Zaslavsky, Arnaud

2017-04-01

If selected, Turbulence Heating ObserveR (THOR) will become the first spacecraft mission dedicated to the study of plasma turbulence. The Fields and Waves Processor (FWP) is an integrated electronics unit for all electromagnetic field measurements performed by THOR. FWP will interface with all THOR fields sensors: electric field antennas of the EFI instrument, the MAG fluxgate magnetometer, and search-coil magnetometer (SCM), and perform signal digitization and on-board data processing. FWP box will house multiple data acquisition sub-units and signal analyzers all sharing a common power supply and data processing unit and thus a single data and power interface to the spacecraft. Integrating all the electromagnetic field measurements in a single unit will improve the consistency of field measurement and accuracy of time synchronization. The scientific value of highly sensitive electric and magnetic field measurements in space has been demonstrated by Cluster (among other spacecraft) and THOR instrumentation will further improve on this heritage. Large dynamic range of the instruments will be complemented by a thorough electromagnetic cleanliness program, which will prevent perturbation of field measurements by interference from payload and platform subsystems. Taking advantage of the capabilities of modern electronics and the large telemetry bandwidth of THOR, FWP will provide multi-component electromagnetic field waveforms and spectral data products at a high time resolution. Fully synchronized sampling of many signals will allow to resolve wave phase information and estimate wavelength via interferometric correlations between EFI probes. FWP will also implement a plasma resonance sounder and a digital plasma quasi-thermal noise analyzer designed to provide high cadence measurements of plasma density and temperature complementary to data from particle instruments. FWP will rapidly transmit information about magnetic field vector and spacecraft potential to the particle instrument data processing unit (PPU) via a dedicated digital link. This information will help particle instruments to optimize energy and angular sweeps and calculate on-board moments. FWP will also coordinate the acquisition of high resolution waveform snapshots with very high time resolution electron data from the TEA instrument. This combined wave/particle measurement will provide the ultimate dataset for investigation of wave-particle interactions on electron scales. The FWP instrument shall be designed and built by an international consortium of scientific institutes from Czech Republic, Poland, France, UK, Sweden and Austria.

Real-time communication architecture for connected-vehicle eco-traffic signal system applications.

DOT National Transportation Integrated Search

2014-02-01

Transportation Systems, and thus Intelligent Transportation Systems (ITS), are considered one of the most critical : infrastructures. For wireless communication ITS use communication links based on Dedicated Short Range Communication : (DSRC) in Wire...

Arduino: a low-cost multipurpose lab equipment.

PubMed

D'Ausilio, Alessandro

2012-06-01

Typical experiments in psychological and neurophysiological settings often require the accurate control of multiple input and output signals. These signals are often generated or recorded via computer software and/or external dedicated hardware. Dedicated hardware is usually very expensive and requires additional software to control its behavior. In the present article, I present some accuracy tests on a low-cost and open-source I/O board (Arduino family) that may be useful in many lab environments. One of the strengths of Arduinos is the possibility they afford to load the experimental script on the board's memory and let it run without interfacing with computers or external software, thus granting complete independence, portability, and accuracy. Furthermore, a large community has arisen around the Arduino idea and offers many hardware add-ons and hundreds of free scripts for different projects. Accuracy tests show that Arduino boards may be an inexpensive tool for many psychological and neurophysiological labs.

System on a chip with MPEG-4 capability

NASA Astrophysics Data System (ADS)

Yassa, Fathy; Schonfeld, Dan

2002-12-01

Current products supporting video communication applications rely on existing computer architectures. RISC processors have been used successfully in numerous applications over several decades. DSP processors have become ubiquitous in signal processing and communication applications. Real-time applications such as speech processing in cellular telephony rely extensively on the computational power of these processors. Video processors designed to implement the computationally intensive codec operations have also been used to address the high demands of video communication applications (e.g., cable set-top boxes and DVDs). This paper presents an overview of a system-on-chip (SOC) architecture used for real-time video in wireless communication applications. The SOC specifications answer to the system requirements imposed by the application environment. A CAM-based video processor is used to accelerate data intensive video compression tasks such as motion estimations and filtering. Other components are dedicated to system level data processing and audio processing. A rich set of I/Os allows the SOC to communicate with other system components such as baseband and memory subsystems.

Fourier emission infrared microspectrophotometer for surface analysis. I - Application to lubrication problems

NASA Technical Reports Server (NTRS)

Lauer, J. L.; King, V. W.

1979-01-01

A far-infrared interferometer was converted into an emission microspectrophotometer for surface analysis. To cover the mid-infrared as well as the far-infrared the Mylar beamsplitter was made replaceable by a germanium-coated salt plate, and the Moire fringe counting system used to locate the moveable Michelson mirror was improved to read 0.5 micron of mirror displacement. Digital electronics and a dedicated minicomputer were installed for data collection and processing. The most critical element for the recording of weak emission spectra from small areas was, however, a reflecting microscope objective and phase-locked signal detection with simultaneous referencing to a blackbody source. An application of the technique to lubrication problems is shown.

An Overview of GNSS Remote Sensing

DTIC Science & Technology

2014-08-27

dedicated space missions and develop- ments of new algorithms and innovative methodologies. Atmospheric sounding is a new area of GNSS applications based on...the analysis of radio signals from GNSS satel - lites, which are refracted as they pass through the atmos- phere and can give information on its...under a full COSMIC constellation. The L-band radio signals broadcast by the GNSS satel - lites are affected by both the ionospheric and tropospheric

In-field Raman amplification on coherent optical fiber links for frequency metrology.

PubMed

Clivati, C; Bolognini, G; Calonico, D; Faralli, S; Mura, A; Levi, F

2015-04-20

Distributed Raman amplification (DRA) is widely exploited for the transmission of broadband, modulated signals used in data links, but not yet in coherent optical links for frequency metrology, where the requirements are rather different. After preliminary tests on fiber spools, in this paper we deeper investigate Raman amplification on deployed in-field optical metrological links. We actually test a Doppler-stabilized optical link both on a 94 km-long metro-network implementation with multiplexed ITU data channels and on a 180 km-long dedicated fiber haul connecting two cities, where DRA is employed in combination with Erbium-doped fiber amplification (EDFA). The performance of DRA is detailed in both experiments, indicating that it does not introduce noticeable penalties for the metrological signal or for the ITU data channels. We hence show that Raman amplification of metrological signals can be compatible with a wavelength division multiplexing architecture and that it can be used as an alternative or in combination with dedicated bidirectional EDFAs. No deterioration is noticed in the coherence properties of the delivered signal, which attains frequency instability at the 10(-19) level in both cases. This study can be of interest also in view of the undergoing deployment of continental fiber networks for frequency metrology.

The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site

PubMed Central

Pillet, Benjamin; García-Gómez, Juan J.; Pausch, Patrick; Falquet, Laurent; Bange, Gert; de la Cruz, Jesús; Kressler, Dieter

2015-01-01

Ribosomes are the highly complex macromolecular assemblies dedicated to the synthesis of all cellular proteins from mRNA templates. The main principles underlying the making of ribosomes are conserved across eukaryotic organisms and this process has been studied in most detail in the yeast Saccharomyces cerevisiae. Yeast ribosomes are composed of four ribosomal RNAs (rRNAs) and 79 ribosomal proteins (r-proteins). Most r-proteins need to be transported from the cytoplasm to the nucleus where they get incorporated into the evolving pre-ribosomal particles. Due to the high abundance and difficult physicochemical properties of r-proteins, their correct folding and fail-safe targeting to the assembly site depends largely on general, as well as highly specialized, chaperone and transport systems. Many r-proteins contain universally conserved or eukaryote-specific internal loops and/or terminal extensions, which were shown to mediate their nuclear targeting and association with dedicated chaperones in a growing number of cases. The 60S r-protein Rpl4 is particularly interesting since it harbours a conserved long internal loop and a prominent C-terminal eukaryote-specific extension. Here we show that both the long internal loop and the C-terminal eukaryote-specific extension are strictly required for the functionality of Rpl4. While Rpl4 contains at least five distinct nuclear localization signals (NLS), the C-terminal part of the long internal loop associates with a specific binding partner, termed Acl4. Absence of Acl4 confers a severe slow-growth phenotype and a deficiency in the production of 60S subunits. Genetic and biochemical evidence indicates that Acl4 can be considered as a dedicated chaperone of Rpl4. Notably, Acl4 localizes to both the cytoplasm and nucleus and it has the capacity to capture nascent Rpl4 in a co-translational manner. Taken together, our findings indicate that the dedicated chaperone Acl4 accompanies Rpl4 from the cytoplasm to its pre-60S assembly site in the nucleus. PMID:26447800

A biophysical model for modulation frequency encoding in the cochlear nucleus.

PubMed

Eguia, Manuel C; Garcia, Guadalupe C; Romano, Sebastian A

2010-01-01

Encoding of amplitude modulated (AM) acoustical signals is one of the most compelling tasks for the mammalian auditory system: environmental sounds, after being filtered and transduced by the cochlea, become narrowband AM signals. Despite much experimental work dedicated to the comprehension of auditory system extraction and encoding of AM information, the neural mechanisms underlying this remarkable feature are far from being understood (Joris et al., 2004). One of the most accepted theories for this processing is the existence of a periodotopic organization (based on temporal information) across the more studied tonotopic axis (Frisina et al., 1990b). In this work, we will review some recent advances in the study of the mechanisms involved in neural processing of AM sounds, and propose an integrated model that runs from the external ear, through the cochlea and the auditory nerve, up to a sub-circuit of the cochlear nucleus (the first processing unit in the central auditory system). We will show that varying the amount of inhibition in our model we can obtain a range of best modulation frequencies (BMF) in some principal cells of the cochlear nucleus. This could be a basis for a synchronicity based, low-level periodotopic organization. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

Performance verification and system integration tests of the pulse shape processor for the soft x-ray spectrometer onboard ASTRO-H

NASA Astrophysics Data System (ADS)

Takeda, Sawako; Tashiro, Makoto S.; Ishisaki, Yoshitaka; Tsujimoto, Masahiro; Seta, Hiromi; Shimoda, Yuya; Yamaguchi, Sunao; Uehara, Sho; Terada, Yukikatsu; Fujimoto, Ryuichi; Mitsuda, Kazuhisa

2014-07-01

The soft X-ray spectrometer (SXS) aboard ASTRO-H is equipped with dedicated digital signal processing units called pulse shape processors (PSPs). The X-ray microcalorimeter system SXS has 36 sensor pixels, which are operated at 50 mK to measure heat input of X-ray photons and realize an energy resolution of 7 eV FWHM in the range 0.3-12.0 keV. Front-end signal processing electronics are used to filter and amplify the electrical pulse output from the sensor and for analog-to-digital conversion. The digitized pulses from the 36 pixels are multiplexed and are sent to the PSP over low-voltage differential signaling lines. Each of two identical PSP units consists of an FPGA board, which assists the hardware logic, and two CPU boards, which assist the onboard software. The FPGA board triggers at every pixel event and stores the triggering information as a pulse waveform in the installed memory. The CPU boards read the event data to evaluate pulse heights by an optimal filtering algorithm. The evaluated X-ray photon data (including the pixel ID, energy, and arrival time information) are transferred to the satellite data recorder along with event quality information. The PSP units have been developed and tested with the engineering model (EM) and the flight model. Utilizing the EM PSP, we successfully verified the entire hardware system and the basic software design of the PSPs, including their communication capability and signal processing performance. In this paper, we show the key metrics of the EM test, such as accuracy and synchronicity of sampling clocks, event grading capability, and resultant energy resolution.

Jazz drummers recruit language-specific areas for the processing of rhythmic structure.

PubMed

Herdener, Marcus; Humbel, Thierry; Esposito, Fabrizio; Habermeyer, Benedikt; Cattapan-Ludewig, Katja; Seifritz, Erich

2014-03-01

Rhythm is a central characteristic of music and speech, the most important domains of human communication using acoustic signals. Here, we investigated how rhythmical patterns in music are processed in the human brain, and, in addition, evaluated the impact of musical training on rhythm processing. Using fMRI, we found that deviations from a rule-based regular rhythmic structure activated the left planum temporale together with Broca's area and its right-hemispheric homolog across subjects, that is, a network also crucially involved in the processing of harmonic structure in music and the syntactic analysis of language. Comparing the BOLD responses to rhythmic variations between professional jazz drummers and musical laypersons, we found that only highly trained rhythmic experts show additional activity in left-hemispheric supramarginal gyrus, a higher-order region involved in processing of linguistic syntax. This suggests an additional functional recruitment of brain areas usually dedicated to complex linguistic syntax processing for the analysis of rhythmical patterns only in professional jazz drummers, who are especially trained to use rhythmical cues for communication.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Philipp, Hugh T., E-mail: htp2@cornell.edu; Tate, Mark W.; Purohit, Prafull

Modern storage rings are readily capable of providing intense x-ray pulses, tens of picoseconds in duration, millions of times per second. Exploiting the temporal structure of these x-ray sources opens avenues for studying rapid structural changes in materials. Many processes (e.g. crack propagation, deformation on impact, turbulence, etc.) differ in detail from one sample trial to the next and would benefit from the ability to record successive x-ray images with single x-ray sensitivity while framing at 5 to 10 MHz rates. To this end, we have pursued the development of fast x-ray imaging detectors capable of collecting bursts of imagesmore » that enable the isolation of single synchrotron bunches and/or bunch trains. The detector technology used is the hybrid pixel array detector (PAD) with a charge integrating front-end, and high-speed, in-pixel signal storage elements. A 384×256 pixel version, the Keck-PAD, with 150 µm × 150 µm pixels and 8 dedicated in-pixel storage elements is operational, has been tested at CHESS, and has collected data for compression wave studies. An updated version with 27 dedicated storage capacitors and identical pixel size has been fabricated.« less

Planetary Radio Interferometry and Doppler Experiment (PRIDE) technique: A test case of the Mars Express Phobos Flyby. II. Doppler tracking: Formulation of observed and computed values, and noise budget

NASA Astrophysics Data System (ADS)

Bocanegra-Bahamón, T. M.; Molera Calvés, G.; Gurvits, L. I.; Duev, D. A.; Pogrebenko, S. V.; Cimò, G.; Dirkx, D.; Rosenblatt, P.

2018-01-01

Context. Closed-loop Doppler data obtained by deep space tracking networks, such as the NASA Deep Space Network (DSN) and the ESA tracking station network (Estrack), are routinely used for navigation and science applications. By shadow tracking the spacecraft signal, Earth-based radio telescopes involved in the Planetary Radio Interferometry and Doppler Experiment (PRIDE) can provide open-loop Doppler tracking data only when the dedicated deep space tracking facilities are operating in closed-loop mode. Aims: We explain the data processing pipeline in detail and discuss the capabilities of the technique and its potential applications in planetary science. Methods: We provide the formulation of the observed and computed values of the Doppler data in PRIDE tracking of spacecraft and demonstrate the quality of the results using an experiment with the ESA Mars Express spacecraft as a test case. Results: We find that the Doppler residuals and the corresponding noise budget of the open-loop Doppler detections obtained with the PRIDE stations compare to the closed-loop Doppler detections obtained with dedicated deep space tracking facilities.

Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli

PubMed Central

Morris, Melody K.; Saez-Rodriguez, Julio; Clarke, David C.; Sorger, Peter K.; Lauffenburger, Douglas A.

2011-01-01

Predictive understanding of cell signaling network operation based on general prior knowledge but consistent with empirical data in a specific environmental context is a current challenge in computational biology. Recent work has demonstrated that Boolean logic can be used to create context-specific network models by training proteomic pathway maps to dedicated biochemical data; however, the Boolean formalism is restricted to characterizing protein species as either fully active or inactive. To advance beyond this limitation, we propose a novel form of fuzzy logic sufficiently flexible to model quantitative data but also sufficiently simple to efficiently construct models by training pathway maps on dedicated experimental measurements. Our new approach, termed constrained fuzzy logic (cFL), converts a prior knowledge network (obtained from literature or interactome databases) into a computable model that describes graded values of protein activation across multiple pathways. We train a cFL-converted network to experimental data describing hepatocytic protein activation by inflammatory cytokines and demonstrate the application of the resultant trained models for three important purposes: (a) generating experimentally testable biological hypotheses concerning pathway crosstalk, (b) establishing capability for quantitative prediction of protein activity, and (c) prediction and understanding of the cytokine release phenotypic response. Our methodology systematically and quantitatively trains a protein pathway map summarizing curated literature to context-specific biochemical data. This process generates a computable model yielding successful prediction of new test data and offering biological insight into complex datasets that are difficult to fully analyze by intuition alone. PMID:21408212

Single-trial analysis of the neural correlates of speech quality perception.

PubMed

Porbadnigk, Anne K; Treder, Matthias S; Blankertz, Benjamin; Antons, Jan-Niklas; Schleicher, Robert; Möller, Sebastian; Curio, Gabriel; Müller, Klaus-Robert

2013-10-01

Assessing speech quality perception is a challenge typically addressed in behavioral and opinion-seeking experiments. Only recently, neuroimaging methods were introduced, which were used to study the neural processing of quality at group level. However, our electroencephalography (EEG) studies show that the neural correlates of quality perception are highly individual. Therefore, it became necessary to establish dedicated machine learning methods for decoding subject-specific effects. The effectiveness of our methods is shown by the data of an EEG study that investigates how the quality of spoken vowels is processed neurally. Participants were asked to indicate whether they had perceived a degradation of quality (signal-correlated noise) in vowels, presented in an oddball paradigm. We find that the P3 amplitude is attenuated with increasing noise. Single-trial analysis allows one to show that this is partly due to an increasing jitter of the P3 component. A novel classification approach helps to detect trials with presumably non-conscious processing at the threshold of perception. We show that this approach uncovers a non-trivial confounder between neural hits and neural misses. The combined use of EEG signals and machine learning methods results in a significant 'neural' gain in sensitivity (in processing quality loss) when compared to standard behavioral evaluation; averaged over 11 subjects, this amounts to a relative improvement in sensitivity of 35%.

Characterization of the ePix100 prototype: a front-end ASIC for second-generation LCLS integrating hybrid pixel detectors

NASA Astrophysics Data System (ADS)

Caragiulo, P.; Dragone, A.; Markovic, B.; Herbst, R.; Nishimura, K.; Reese, B.; Herrmann, S.; Hart, P.; Blaj, G.; Segal, J.; Tomada, A.; Hasi, J.; Carini, G.; Kenney, C.; Haller, G.

2014-09-01

ePix100 is the first variant of a novel class of integrating pixel ASICs architectures optimized for the processing of signals in second generation LINAC Coherent Light Source (LCLS) X-Ray cameras. ePix100 is optimized for ultra-low noise application requiring high spatial resolution. ePix ASICs are based on a common platform composed of a random access analog matrix of pixel with global shutter, fast parallel column readout, and dedicated sigma-delta analog to digital converters per column. The ePix100 variant has 50μmx50μm pixels arranged in a 352x384 matrix, a resolution of 50e- r.m.s. and a signal range of 35fC (100 photons at 8keV). In its final version it will be able to sustain a frame rate of 1kHz. A first prototype has been fabricated and characterized and the measurement results are reported here.

A lithospheric magnetic field model derived from the Swarm satellite magnetic field measurements

NASA Astrophysics Data System (ADS)

Hulot, G.; Thebault, E.; Vigneron, P.

2015-12-01

The Swarm constellation of satellites was launched in November 2013 and has since then delivered high quality scalar and vector magnetic field measurements. A consortium of several research institutions was selected by the European Space Agency (ESA) to provide a number of scientific products which will be made available to the scientific community. Within this framework, specific tools were tailor-made to better extract the magnetic signal emanating from Earth's the lithospheric. These tools rely on the scalar gradient measured by the lower pair of Swarm satellites and rely on a regional modeling scheme that is more sensitive to small spatial scales and weak signals than the standard spherical harmonic modeling. In this presentation, we report on various activities related to data analysis and processing. We assess the efficiency of this dedicated chain for modeling the lithospheric magnetic field using more than one year of measurements, and finally discuss refinements that are continuously implemented in order to further improve the robustness and the spatial resolution of the lithospheric field model.

Ion temperature measurements of indirect-drive implosions with the neutron time-of-flight detector on SG-III laser facility

NASA Astrophysics Data System (ADS)

Chen, Zhongjing; Zhang, Xing; Pu, Yudong; Yan, Ji; Huang, Tianxuan; Jiang, Wei; Yu, Bo; Chen, Bolun; Tang, Qi; Song, Zifeng; Chen, Jiabin; Zhan, Xiayu; Liu, Zhongjie; Xie, Xufei; Jiang, Shaoen; Liu, Shenye

2018-02-01

The accuracy of the determination of the burn-averaged ion temperature of inertial confinement fusion implosions depends on the unfold process, including deconvolution and convolution methods, and the function, i.e., the detector response, used to fit the signals measured by neutron time-of-flight (nToF) detectors. The function given by Murphy et al. [Rev. Sci. Instrum. 68(1), 610-613 (1997)] has been widely used in Nova, Omega, and NIF. There are two components, i.e., fast and slow, and the contribution of scattered neutrons has not been dedicatedly considered. In this work, a new function, based on Murphy's function has been employed to unfold nToF signals. The contribution of scattered neutrons is easily included by the convolution of a Gaussian response function and an exponential decay. The ion temperature is measured by nToF with the new function. Good agreement with the ion temperature determined by the deconvolution method has been achieved.

Study and Application of a Multi Magnetoresistor Sensor System to Detect Corrosion in Suspension Cables

NASA Astrophysics Data System (ADS)

Torres, V.; Quek, S.; Gaydecki, P.

2010-02-01

Aging and deterioration of the main functional parts in civil structures is one of the biggest problems that private and governmental institutions, dedicated to operate and maintain such structures, are facing now days. In the case of relatively old suspension bridges, problems emerge due to corrosion and break of wires in the main cables. Decisive information and a reliable monitoring and evaluation are factors of great relevance required to prevent significant or catastrophic damages caused to the structure, and more importantly, to people. The main challenge for the NDE methods of inspection arises in dealing with the steel wrapping barrier of the suspension cable, which main function is to shield, shape and hold the bundles. The following work, presents a study of a multi-Magnetoresistive sensors system aiming to support the monitoring and evaluation of suspension cables at some of its stages. Modelling, signal acquisition, signal processing, experiments and the initial phases of implementation are presented and discussed widely.

Ultranarrowband searches for extraterrestrial intelligence with dedicated signal-processing hardware.

PubMed

Horowitz, P; Matthews, B S; Forster, J; Linscott, I; Teague, C C; Chen, K; Backus, P

1986-01-01

Multichannel spectroscopy with millihertz resolution constitutes an attractive strategy for a microwave search for extraterrestrial intelligence (SETI), assuming the transmission of a narrow-band radiofrequency beacon. Such resolution matches the properties of the interstellar medium, and the necessary receiver Doppler corrections provide a high degree of interference rejection. We have constructed a frequency-agile swept receiver with an 8,388,608-channel spectrum analyzer, on-line signal recognition, and multithreshold archiving. A search of 250 Sun-like stars at 1.4 and 2.8 GHz has been carried out with the Arecibo 305-m antenna, and a meridian transit search of the northern sky is in progress at the Harvard-Smithsonian 26-m antenna. Successive spectra of 400 kHz at 0.05 Hz resolution are searched for features characteristic of an intentional narrowband beacon transmission. These spectra are centered on guessable ("magic") frequencies (such as the 21-cm hydrogen hyperfine line), referenced successively to the local standard of rest, the galactic barycenter, and the cosmic blackbody rest frame.

The Serendip II design. [narrowband astronautical radio signal search for extraterrestrial intelligence

NASA Technical Reports Server (NTRS)

Werthimer, D.; Tarter, J.; Bowyer, S.

1985-01-01

Serendip II is an automated system designed to perform a real time search for narrow band radio signals in the spectra of sources in a regularly scheduled, non-Seti, astronomical observing program. Because Serendip II is expected to run continuously without requiring dedicated observing time, it is hoped that a large portion of the sky will be surveyed at high sensitivity and low cost. Serendip II will compute the power spectrum using a 65,536 channel fast Fourier transform processor with a real time bandwidth of 128 KHz and 2 Hz per channel resolution. After searching for peaks in a 100 KHz portion of the radio telescope's IF band, Serendip II will move to the next 100 KHz portion using a programmable frequency synthesizer; when the whole IF band has been scanned, the process will start again. Unidentified peaks in the power spectra are candidates for further study and their celestial coordinates will be recorded along with the time and power, IF and RF frequency, and bandwidth of the peak.

Efficient Process Migration for Parallel Processing on Non-Dedicated Networks of Workstations

NASA Technical Reports Server (NTRS)

Chanchio, Kasidit; Sun, Xian-He

1996-01-01

This paper presents the design and preliminary implementation of MpPVM, a software system that supports process migration for PVM application programs in a non-dedicated heterogeneous computing environment. New concepts of migration point as well as migration point analysis and necessary data analysis are introduced. In MpPVM, process migrations occur only at previously inserted migration points. Migration point analysis determines appropriate locations to insert migration points; whereas, necessary data analysis provides a minimum set of variables to be transferred at each migration pint. A new methodology to perform reliable point-to-point data communications in a migration environment is also discussed. Finally, a preliminary implementation of MpPVM and its experimental results are presented, showing the correctness and promising performance of our process migration mechanism in a scalable non-dedicated heterogeneous computing environment. While MpPVM is developed on top of PVM, the process migration methodology introduced in this study is general and can be applied to any distributed software environment.

Real time software for a heat recovery steam generator control system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Valdes, R.; Delgadillo, M.A.; Chavez, R.

1995-12-31

This paper is addressed to the development and successful implementation of a real time software for the Heat Recovery Steam Generator (HRSG) control system of a Combined Cycle Power Plant. The real time software for the HRSG control system physically resides in a Control and Acquisition System (SAC) which is a component of a distributed control system (DCS). The SAC is a programmable controller. The DCS installed at the Gomez Palacio power plant in Mexico accomplishes the functions of logic, analog and supervisory control. The DCS is based on microprocessors and the architecture consists of workstations operating as a Man-Machinemore » Interface (MMI), linked to SAC controllers by means of a communication system. The HRSG real time software is composed of an operating system, drivers, dedicated computer program and application computer programs. The operating system used for the development of this software was the MultiTasking Operating System (MTOS). The application software developed at IIE for the HRSG control system basically consisted of a set of digital algorithms for the regulation of the main process variables at the HRSG. By using the multitasking feature of MTOS, the algorithms are executed pseudo concurrently. In this way, the applications programs continuously use the resources of the operating system to perform their functions through a uniform service interface. The application software of the HRSG consist of three tasks, each of them has dedicated responsibilities. The drivers were developed for the handling of hardware resources of the SAC controller which in turn allows the signals acquisition and data communication with a MMI. The dedicated programs were developed for hardware diagnostics, task initializations, access to the data base and fault tolerance. The application software and the dedicated software for the HRSG control system was developed using C programming language due to compactness, portability and efficiency.« less

Domestic Event Support Operations (DESO)

DTIC Science & Technology

2012-02-01

Examples include EOD Technicians, doctors, nurses , and signalers. The capability also needed dedicated support from DSTO, which eventually became...attacks led to the postponement of CHOGM 2001 and the suspension of Operation GUARDIAN. The activity was rescheduled for March 2002 to be held in the

Spectrum requirements for dedicated short range communications (DSRC) : public safety and commercial applications

DOT National Transportation Integrated Search

1996-07-01

This is the third in a sequence of papers that present the factors involved in identifying the : radio frequency spectrum required for both current and future DSRC operations. Since the : proposed applications, signal characteristics and channel allo...

Spatiotemporal video deinterlacing using control grid interpolation

NASA Astrophysics Data System (ADS)

Venkatesan, Ragav; Zwart, Christine M.; Frakes, David H.; Li, Baoxin

2015-03-01

With the advent of progressive format display and broadcast technologies, video deinterlacing has become an important video-processing technique. Numerous approaches exist in the literature to accomplish deinterlacing. While most earlier methods were simple linear filtering-based approaches, the emergence of faster computing technologies and even dedicated video-processing hardware in display units has allowed higher quality but also more computationally intense deinterlacing algorithms to become practical. Most modern approaches analyze motion and content in video to select different deinterlacing methods for various spatiotemporal regions. We introduce a family of deinterlacers that employs spectral residue to choose between and weight control grid interpolation based spatial and temporal deinterlacing methods. The proposed approaches perform better than the prior state-of-the-art based on peak signal-to-noise ratio, other visual quality metrics, and simple perception-based subjective evaluations conducted by human viewers. We further study the advantages of using soft and hard decision thresholds on the visual performance.

DSP Implementation of the Retinex Image Enhancement Algorithm

NASA Technical Reports Server (NTRS)

Hines, Glenn; Rahman, Zia-Ur; Jobson, Daniel; Woodell, Glenn

2004-01-01

The Retinex is a general-purpose image enhancement algorithm that is used to produce good visual representations of scenes. It performs a non-linear spatial/spectral transform that synthesizes strong local contrast enhancement and color constancy. A real-time, video frame rate implementation of the Retinex is required to meet the needs of various potential users. Retinex processing contains a relatively large number of complex computations, thus to achieve real-time performance using current technologies requires specialized hardware and software. In this paper we discuss the design and development of a digital signal processor (DSP) implementation of the Retinex. The target processor is a Texas Instruments TMS320C6711 floating point DSP. NTSC video is captured using a dedicated frame-grabber card, Retinex processed, and displayed on a standard monitor. We discuss the optimizations used to achieve real-time performance of the Retinex and also describe our future plans on using alternative architectures.

Investigation of Lung Structure-Function Relationships Using Hyperpolarized Noble Gases

NASA Astrophysics Data System (ADS)

Thomen, Robert P.

Magnetic Resonance Imaging (MRI) is an application of the nuclear magnetic resonance (NMR) phenomenon to non-invasively generate 3D tomographic images. MRI is an emerging modality for the lung, but it suffers from low sensitivity due to inherent low tissue density and short T(*/2) . Hyperpolarization is a process by which the nuclear contribution to NMR signal is greatly enhanced to more than 100,000 times that of samples in thermal equilibrium. The noble gases 3He and 129Xe are most often hyperpolarized by transfer of light angular momentum through the electron of a vaporized alkali metal to the noble gas nucleus (called Spin Exchange Optical Pumping). The enhancement in NMR signal is so great that the gas itself can be imaged via MRI, and because noble gases are chemically inert, they can be safely inhaled by a subject, and the gas distribution within the interior of the lung can be imaged. The mechanics of respiration is an elegant physical process by which air is is brought into the distal airspaces of the lungs for oxygen/carbon dioxide gas exchange with blood. Therefore proper description of lung function is intricately related to its physical structure , and the basic mechanical operation of healthy lungs -- from pressure driven airflow, to alveolar airspace gas kinetics, to gas exchange by blood/gas concentration gradients, to elastic contraction of parenchymal tissue -- is a process decidedly governed by the laws of physics. This dissertation will describe experiments investigating the relationship of lung structure and function using hyperpolarized (HP) noble gas MRI. In particular HP gases will be applied to the study of several pulmonary diseases each of which demonstrates unique structure-function abnormalities: asthma, cystic fibrosis, and chronic obstructive pulmonary disease. Successful implementation of an HP gas acquisition protocol for pulmonary studies is an involved and stratified undertaking which requires a solid theoretical foundation in NMR and hyperpolarization theory, construction of dedicated hardware, development of dedicated software, and appropriate image analysis techniques for all acquired data. The author has been actively involved in each of these and has dedicated specific chapters of this dissertation to their description. First, a brief description of lung structure-function investigations and pulmonary imaging will be given (chapter 1). Brief discussions of basic NMR, MRI, and hyperpolarization theory will be given (chapters 2 and 3) followed by their particular methods of implementation in this work (chapters 4 and 5). Analysis of acquired HP gas images will be discussed (chapter 6), and the investigational procedures and results for each lung disease examined will be detailed (chapter 7). Finally, a quick digression on the strengths and limitations of HP gas MRI will be provided (chapter 8).

Reactor Operations Monitoring System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hart, M.M.

1989-01-01

The Reactor Operations Monitoring System (ROMS) is a VME based, parallel processor data acquisition and safety action system designed by the Equipment Engineering Section and Reactor Engineering Department of the Savannah River Site. The ROMS will be analyzing over 8 million signal samples per minute. Sixty-eight microprocessors are used in the ROMS in order to achieve a real-time data analysis. The ROMS is composed of multiple computer subsystems. Four redundant computer subsystems monitor 600 temperatures with 2400 thermocouples. Two computer subsystems share the monitoring of 600 reactor coolant flows. Additional computer subsystems are dedicated to monitoring 400 signals from assortedmore » process sensors. Data from these computer subsystems are transferred to two redundant process display computer subsystems which present process information to reactor operators and to reactor control computers. The ROMS is also designed to carry out safety functions based on its analysis of process data. The safety functions include initiating a reactor scram (shutdown), the injection of neutron poison, and the loadshed of selected equipment. A complete development Reactor Operations Monitoring System has been built. It is located in the Program Development Center at the Savannah River Site and is currently being used by the Reactor Engineering Department in software development. The Equipment Engineering Section is designing and fabricating the process interface hardware. Upon proof of hardware and design concept, orders will be placed for the final five systems located in the three reactor areas, the reactor training simulator, and the hardware maintenance center.« less

Robust real-time extraction of respiratory signals from PET list-mode data

NASA Astrophysics Data System (ADS)

Salomon, André; Zhang, Bin; Olivier, Patrick; Goedicke, Andreas

2018-06-01

Respiratory motion, which typically cannot simply be suspended during PET image acquisition, affects lesions’ detection and quantitative accuracy inside or in close vicinity to the lungs. Some motion compensation techniques address this issue via pre-sorting (‘binning’) of the acquired PET data into a set of temporal gates, where each gate is assumed to be minimally affected by respiratory motion. Tracking respiratory motion is typically realized using dedicated hardware (e.g. using respiratory belts and digital cameras). Extracting respiratory signals directly from the acquired PET data simplifies the clinical workflow as it avoids handling additional signal measurement equipment. We introduce a new data-driven method ‘combined local motion detection’ (CLMD). It uses the time-of-flight (TOF) information provided by state-of-the-art PET scanners in order to enable real-time respiratory signal extraction without additional hardware resources. CLMD applies center-of-mass detection in overlapping regions based on simple back-positioned TOF event sets acquired in short time frames. Following a signal filtering and quality-based pre-selection step, the remaining extracted individual position information over time is then combined to generate a global respiratory signal. The method is evaluated using seven measured FDG studies from single and multiple scan positions of the thorax region, and it is compared to other software-based methods regarding quantitative accuracy and statistical noise stability. Correlation coefficients around 90% between the reference and the extracted signal have been found for those PET scans where motion affected features such as tumors or hot regions were present in the PET field-of-view. For PET scans with a quarter of typically applied radiotracer doses, the CLMD method still provides similar high correlation coefficients which indicates its robustness to noise. Each CLMD processing needed less than 0.4 s in total on a standard multi-core CPU and thus provides a robust and accurate approach enabling real-time processing capabilities using standard PC hardware.

GLORI (GLObal navigation satellite system Reflectometry Instrument): A New Airborne GNSS-R receiver for land surface applications

NASA Astrophysics Data System (ADS)

Motte, Erwan; Zribi, Mehrez; Fanise, Pascal

2015-04-01

GLORI (GLObal navigation satellite system Reflectometry Instrument) is a new receiver dedicated to the airborne measurement of surface parameters such as soil moisture and biomass above ground and sea state (wave height and direction) above oceans. The instrument is based on the PARIS concept [Martin-Neira, 1993] using both the direct and surface-reflected L-band signals from the GPS constellation as a multistatic radar source. The receiver is based on one up-looking and one down-looking dual polarization hemispherical active antennas feeding a low-cost 4-channel SDR direct down-conversion receiver tuned to the GPS L1 frequency. The raw measurements are sampled at 16.368MHz and stored as 2-bit, IQ binary files. In post-processing, GPS acquisition and tracking are performed on the direct up-looking signal while the down-looking signal is processed blindly using tracking parameters from the direct signal. The obtained direct and reflected code-correlation waveforms are the basic observables for geophysical parameters inversion. The instrument was designed to be installed aboard the ATR42 experimental aircraft from the French SAFIRE fleet as a permanent payload. The long term goal of the project is to provide real-time continuous surface information for every flight performed. The aircraft records attitude information through its Inertial Measurement Unit and a commercial GPS receiver records additional information such as estimated doppler and code phase, receiver location, satellites azimuth and elevation. A series of test flights were performed over both the Toulouse and Gulf of Lion (Mediterranean Sea) regions during the period 17-21 Nov 2014 together with the KuROS radar [Hauser et al., 2014]. Using processing methods from the literature [Egido et al., 2014], preliminary results demonstrate the instrument sensitivity to both ground and ocean surface parameters estimation. A dedicated scientific flight campaign is planned at the end of second quarter 2015 with collocated measurement of biomass and soil moisture ground truth in order to better characterize the instrument sensitivity to geophysical parameters. The instrument will be improved in the meanwhile including the optimization of data processing and the better integration of external data (GPS commercial receiver, Attitude) into the receiver. M.Martin-Neira. A Passive reflectometry and interferometry system (PARIS): Application to ocean altimetry. ESA J., 17:331-355, 1993 Hauser, D.; Caudal, G.; Le Gac, C.; Valentin, R.; Delaye, L.; Tison, C., "KuROS: A new airborne Ku-band Doppler radar for observation of the ocean surface," Geoscience and Remote Sensing Symposium (IGARSS), 2014 IEEE International , vol., no., pp.282,285, 13-18 July 2014 Egido, A.; Paloscia, S.; Motte, E.; Guerriero, L.; Pierdicca, N.; Caparrini, M.; Santi, E.; Fontanelli, G.; Floury, N., "Airborne GNSS-R Polarimetric Measurements for Soil Moisture and Above-Ground Biomass Estimation," Selected Topics in Applied Earth Observations and Remote Sensing, IEEE Journal of , vol.7, no.5, pp.1522,1532, May 2014

Commissioning of a new wide-bore MRI scanner for radiotherapy planning of head and neck cancer

PubMed Central

Liney, G P; Owen, S C; Beaumont, A K E; Lazar, V R; Manton, D J

2013-01-01

Objective: A combination of CT and MRI is recommended for radiotherapy planning of head and neck cancers, and optimal spatial co-registration is achieved by imaging in the treatment position using the necessary immobilisation devices on both occasions, something which requires wide-bore scanners. Quality assurance experiments were carried out to commission a newly installed 1.5-T wide-bore MRI scanner and a dedicated, flexible six-channel phased array head and neck coil. Methods: Signal-to-noise ratio (SNR) and spatial signal uniformity were quantified using a homogeneous aqueous phantom, and geometric distortion was quantified using a phantom with water-filled fiducials in a grid pattern. Volunteer scans were also used to determine the in vivo image quality. Clinically relevant T1 weighted and T2 weighted fat-suppressed sequences were assessed in multiple scan planes (both sequences fast spin echo based). The performance of two online signal uniformity correction schemes, one utilising low-resolution reference scans and the other not utilising low-resolution reference scans, was compared. Results: Geometric distortions, for a ±35-kHz bandwidth, were <1 mm for locations within 10 cm of the isocentre rising to 1.8 mm at 18 cm away. SNR was above 50, and uniformity in the axial plane was 71% and 95% before and after uniformity correction, respectively. Conclusion: The combined performance of the wide-bore scanner and the dedicated coil was adjudged adequate, although superior–inferior spatial coverage was slightly limited in the lower neck. Advances in knowledge: These results will be of interest to the increasing number of oncology centres that are seeking to incorporate MRI into planning practice using dedicated equipment. PMID:23690434

Evolution of olfactory receptors.

PubMed

Hoover, Kara C

2013-01-01

Olfactory receptors are a specialized set of receptor cells responsible for the detection of odors. These cells are G protein-coupled receptors and expressed in the cell membranes of olfactory sensory neurons. Once a cell is activated by a ligand, it initiates a signal transduction cascade that produces a nerve impulse to the brain where odor perception is processed. Vertebrate olfactory evolution is characterized by birth-and-death events, a special case of the stochastic continuous time Markov process. Vertebrate fish have three general types of receptor cells (two dedicated to pheromones). Terrestrial animals have different epithelial biology due to the specialized adaptation to detecting airborne odors. Two general classes of olfactory receptor gene reflect the vertebrate marine heritage (Class I) and the derived amphibian, reptile, and mammal terrestrial heritage (Class II). While we know much about olfactory receptor cells, there are still areas where our knowledge is insufficient, such as intra-individual diversity throughout the life time, epigenetic processes acting on olfactory receptors, and association of ligands to specific cells.

Fundamental performance determining factors of the ultrahigh-precision space-borne optical metrology system for the LISA Pathfinder mission

NASA Astrophysics Data System (ADS)

Hechenblaikner, Gerald; Flatscher, Reinhold

2013-05-01

The LISA Pathfinder mission to space employs an optical metrology system (OMS) at its core to measure the distance and attitude between two freely floating test-masses to picometer and nanorad accuracy, respectively, within the measurement band of [1 mHz, 30 mHz]. The OMS is based upon an ultra-stable optical bench with 4 heterodyne interferometers from which interference signals are read-out and processed by a digital phase-meter. Laser frequency noise, power fluctuations and optical path-length variations are suppressed to uncritical levels by dedicated control loops so that the measurement performance approaches the sensor limit imposed by the phasemeter. The system design is such that low frequency common mode noise which affects the read-out phase of all four interferometers is generally well suppressed by subtraction of a reference phase from the other interferometer signals. However, high frequency noise directly affects measurement performance and its common mode rejection depends strongly on the relative signal phases. We discuss how the data from recent test campaigns point towards high frequency phase noise as a likely performance limiting factor which explains some important performance features.

Applying Online Monitoring for Nuclear Power Plant Instrumentation and Control

NASA Astrophysics Data System (ADS)

Hashemian, H. M.

2010-10-01

This paper presents a practical review of the state-of-the-art means for applying OLM data acquisition in nuclear power plant instrumentation and control, qualifying or validating the OLM data, and then analyzing it for static and dynamic performance monitoring applications. Whereas data acquisition for static or steady-state OLM applications can require sample rates of anywhere from 1 to 10 seconds to 1 minutes per sample, for dynamic data acquisition, higher sampling frequencies are required (e.g., 100 to 1000 Hz) using a dedicated data acquisition system capable of providing isolation, anti-aliasing and removal of extraneous noise, and analog-to-digital (A/D) conversion. Qualifying the data for use with OLM algorithms can involve removing data `dead' spots (for static data) and calculating, examining, and trending amplitude probability density, variance, skewness, and kurtosis. For static OLM applications with redundant signals, trending and averaging qualification techniques are used, and for single or non-redundant signals physical and empirical modeling are used. Dynamic OLM analysis is performed in the frequency domain and/or time domain, and is based on the assumption that sensors' or transmitters' dynamic characteristics are linear and that the input noise signal (i.e., the process fluctuations) has proper spectral characteristics.

General-purpose readout electronics for white neutron source at China Spallation Neutron Source

NASA Astrophysics Data System (ADS)

Wang, Q.; Cao, P.; Qi, X.; Yu, T.; Ji, X.; Xie, L.; An, Q.

2018-01-01

The under-construction White Neutron Source (WNS) at China Spallation Neutron Source is a facility for accurate measurements of neutron-induced cross section. Seven spectrometers are planned at WNS. As the physical objectives of each spectrometer are different, the requirements for readout electronics are not the same. In order to simplify the development of the readout electronics, this paper presents a general method for detector signal readout. This method has advantages of expansibility and flexibility, which makes it adaptable to most detectors at WNS. In the WNS general-purpose readout electronics, signals from any kinds of detectors are conditioned by a dedicated signal conditioning module corresponding to this detector, and then digitized by a common waveform digitizer with high speed and high precision (1 GSPS at 12-bit) to obtain the full waveform data. The waveform digitizer uses a field programmable gate array chip to process the data stream and trigger information in real time. PXI Express platform is used to support the functionalities of data readout, clock distribution, and trigger information exchange between digitizers and trigger modules. Test results show that the performance of the WNS general-purpose readout electronics can meet the requirements of the WNS spectrometers.

Modulators of Stomatal Lineage Signal Transduction Alter Membrane Contact Sites and Reveal Specialization among ERECTA Kinases.

PubMed

Ho, Chin-Min Kimmy; Paciorek, Tomasz; Abrash, Emily; Bergmann, Dominique C

2016-08-22

Signal transduction from a cell's surface to its interior requires dedicated signaling elements and a cellular environment conducive to signal propagation. Plant development, defense, and homeostasis rely on plasma membrane receptor-like kinases to perceive endogenous and environmental signals, but little is known about their immediate downstream targets and signaling modifiers. Using genetics, biochemistry, and live-cell imaging, we show that the VAP-RELATED SUPPRESSOR OF TMM (VST) family is required for ERECTA-mediated signaling in growth and cell-fate determination and reveal a role for ERECTA-LIKE2 in modulating signaling by its sister kinases. We show that VSTs are peripheral plasma membrane proteins that can form complexes with integral ER-membrane proteins, thereby potentially influencing the organization of the membrane milieu to promote efficient and differential signaling from the ERECTA-family members to their downstream intracellular targets. Copyright © 2016 Elsevier Inc. All rights reserved.

Why the Brain Knows More than We Do: Non-Conscious Representations and Their Role in the Construction of Conscious Experience

PubMed Central

Dresp-Langley, Birgitta

2011-01-01

Scientific studies have shown that non-conscious stimuli and representations influence information processing during conscious experience. In the light of such evidence, questions about potential functional links between non-conscious brain representations and conscious experience arise. This article discusses neural model capable of explaining how statistical learning mechanisms in dedicated resonant circuits could generate specific temporal activity traces of non-conscious representations in the brain. How reentrant signaling, top-down matching, and statistical coincidence of such activity traces may lead to the progressive consolidation of temporal patterns that constitute the neural signatures of conscious experience in networks extending across large distances beyond functionally specialized brain regions is then explained. PMID:24962683

Control of Prosthetic Hands via the Peripheral Nervous System

PubMed Central

Ciancio, Anna Lisa; Cordella, Francesca; Barone, Roberto; Romeo, Rocco Antonio; Bellingegni, Alberto Dellacasa; Sacchetti, Rinaldo; Davalli, Angelo; Di Pino, Giovanni; Ranieri, Federico; Di Lazzaro, Vincenzo; Guglielmelli, Eugenio; Zollo, Loredana

2016-01-01

This paper intends to provide a critical review of the literature on the technological issues on control and sensorization of hand prostheses interfacing with the Peripheral Nervous System (i.e., PNS), and their experimental validation on amputees. The study opens with an in-depth analysis of control solutions and sensorization features of research and commercially available prosthetic hands. Pros and cons of adopted technologies, signal processing techniques and motion control solutions are investigated. Special emphasis is then dedicated to the recent studies on the restoration of tactile perception in amputees through neural interfaces. The paper finally proposes a number of suggestions for designing the prosthetic system able to re-establish a bidirectional communication with the PNS and foster the prosthesis natural control. PMID:27092041

First Results & Future Prospects for 30 GeV Gamma Rays from CELESTE

NASA Astrophysics Data System (ADS)

de Naurois, Mathieu

The CELESTE solar farm gamma-ray telescope detected the Crab Nebula at 80 GeV ( Hz) using 18 heliostats in 1998. In March 1999, observations began with a setup extended to 40 heliostats, and with upgraded electronics. Technical delays and bad weather only permitted a very small data set for the Crab nebula. hours of data were taken simultaneously with the CAT imaging telescope showing evidence for a gamma signal. In this talk the analysis method of these data is described. CELESTE has passed major milestones and the groundwork is laid for the blazar and pulsar studies presented elsewhere in this conference (OG 2.1.20, OG 2.2.31). DEDICATION : CELESTE is the brainchild of Eric Pare, who died at the age of 39 in an automobile accident, two weeks after finding our first gamma ray signal. Eric also played a major role in the conception and design of CAT. We dedicate this work to his memory.

Dedication file preparation for commercial-grade electric components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hendricks, J.R.; Farwell, C.R. Jr.

1988-01-01

Dedication is the process of making a commercial-grade item into a basic component that can be installed in safety systems. This process ensures that the commercially manufactured items are of the same or equivalent form, fit, function, and materials as the originally provided safety item. This process must ensure that the original utility's equipment qualification program is maintained per licensing commitments to 10CFR50.49 and general design criterion No. 4. Today, utilities recognize the need for establishing a dedication program to provide the flexibility in obtaining replacement items directly from the original manufacturers. This need has arisen because (a) most systemmore » houses, large manufacturers, and component manufacturers will sell their products only through distributors as straight commercial-grade items or only service former clients, and (b) lack of competition for specific safety-related items has resulted in excessive hardware cost and very long delivery schedules, which could affect plant availability. The vehicle for utilities to obtain safety-related items is to establish and manage a comprehensive dedication program for their own use or provide the direction for a nuclear supplier to follow. This paper provides both utilities and nuclear suppliers insight into the complexities of a dedication program. This insight is provided from our experience as a utilities agent and as a third-party nuclear supplier.« less

Genomics to feed a switchgrass breeding program

USDA-ARS?s Scientific Manuscript database

Development of improved cultivars is one of three pillars, along with sustainable production and efficient conversion, required for dedicated cellulosic bioenergy crops to succeed. Breeding new cultivars is a long, slow process requiring patience, dedication, and motivation to realize gains and adva...

Performance of a high-sensitivity dedicated cardiac SPECT scanner for striatal uptake quantification in the brain based on analysis of projection data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Mi-Ae; Moore, Stephen C.; McQuaid, Sarah J.

Purpose: The authors have previously reported the advantages of high-sensitivity single-photon emission computed tomography (SPECT) systems for imaging structures located deep inside the brain. DaTscan (Isoflupane I-123) is a dopamine transporter (DaT) imaging agent that has shown potential for early detection of Parkinson disease (PD), as well as for monitoring progression of the disease. Realizing the full potential of DaTscan requires efficient estimation of striatal uptake from SPECT images. They have evaluated two SPECT systems, a conventional dual-head gamma camera with low-energy high-resolution collimators (conventional) and a dedicated high-sensitivity multidetector cardiac imaging system (dedicated) for imaging tasks related to PD.more » Methods: Cramer-Rao bounds (CRB) on precision of estimates of striatal and background activity concentrations were calculated from high-count, separate acquisitions of the compartments (right striata, left striata, background) of a striatal phantom. CRB on striatal and background activity concentration were calculated from essentially noise-free projection datasets, synthesized by scaling and summing the compartment projection datasets, for a range of total detected counts. They also calculated variances of estimates of specific-to-nonspecific binding ratios (BR) and asymmetry indices from these values using propagation of error analysis, as well as the precision of measuring changes in BR on the order of the average annual decline in early PD. Results: Under typical clinical conditions, the conventional camera detected 2 M counts while the dedicated camera detected 12 M counts. Assuming a normal BR of 5, the standard deviation of BR estimates was 0.042 and 0.021 for the conventional and dedicated system, respectively. For an 8% decrease to BR = 4.6, the signal-to-noise ratio were 6.8 (conventional) and 13.3 (dedicated); for a 5% decrease, they were 4.2 (conventional) and 8.3 (dedicated). Conclusions: This implies that PD can be detected earlier with the dedicated system than with the conventional system; therefore, earlier identification of PD progression should be possible with the high-sensitivity dedicated SPECT camera.« less

Aiding and abetting roles of NOX oxidases in cellular transformation

PubMed Central

Block, Karen; Gorin, Yves

2013-01-01

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen species-generating enzymes that broadly and specifically regulate redox-sensitive signalling pathways that are involved in cancer development and progression. They act at specific cellular membranes and microdomains through the activation of oncogenes and the inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived ROS, and the biological role of NOX oxidases in the aetiology of cancer. PMID:22918415

Support-vector-machines-based multidimensional signal classification for fetal activity characterization

NASA Astrophysics Data System (ADS)

Ribes, S.; Voicu, I.; Girault, J. M.; Fournier, M.; Perrotin, F.; Tranquart, F.; Kouamé, D.

2011-03-01

Electronic fetal monitoring may be required during the whole pregnancy to closely monitor specific fetal and maternal disorders. Currently used methods suffer from many limitations and are not sufficient to evaluate fetal asphyxia. Fetal activity parameters such as movements, heart rate and associated parameters are essential indicators of the fetus well being, and no current device gives a simultaneous and sufficient estimation of all these parameters to evaluate the fetus well-being. We built for this purpose, a multi-transducer-multi-gate Doppler system and developed dedicated signal processing techniques for fetal activity parameter extraction in order to investigate fetus's asphyxia or well-being through fetal activity parameters. To reach this goal, this paper shows preliminary feasibility of separating normal and compromised fetuses using our system. To do so, data set consisting of two groups of fetal signals (normal and compromised) has been established and provided by physicians. From estimated parameters an instantaneous Manning-like score, referred to as ultrasonic score was introduced and was used together with movements, heart rate and associated parameters in a classification process using Support Vector Machines (SVM) method. The influence of the fetal activity parameters and the performance of the SVM were evaluated using the computation of sensibility, specificity, percentage of support vectors and total classification accuracy. We showed our ability to separate the data into two sets : normal fetuses and compromised fetuses and obtained an excellent matching with the clinical classification performed by physician.

Hardware requirements: A new generation partial reflection radar for studies of the equatorial mesosphere

NASA Technical Reports Server (NTRS)

Vincent, R. A.

1986-01-01

A new partial reflection (PR) radar is being developed for operation at the proposed Equatorial Observatory. The system is being designed to make maximum use of recent advances in solid-state technology in order to minimize the power requirements. In particular, it is planned to use a solid-state transmitter in place of the tube transmitters previously used in PR systems. Solid-state transmitters have the advantages that they do not need high voltage supplies, they do not require cathode heaters with a corresponding saving in power consumption and parts are readily available and inexpensive. It should be possible to achieve 15 kW peak powers with recently announced fast switching transistors. Since high mean powers are desirable for obtaining good signal-to-noise ratios, it is also planned to phase code the transmitted pulses and decode after coherent integration. All decoding and signal processing will be carried out in dedicated microprocessors before the signals are passed to a microcomputer for on-line analysis. Recent tests have shown that an Olivetti M24 micro (an IBM compatible) running an 8-MHz clock with a 8087 coprocessor can analyze data at least as fast as the minicomputers presently being used with the Adelaide PR rad ar and at a significantly lower cost. The processed winds data will be stored in nonvolatile CMOS RAM modules; about 0.5 to 1 Mbyte is required to store one week's information.

Robust real-time extraction of respiratory signals from PET list-mode data.

PubMed

Salomon, Andre; Zhang, Bin; Olivier, Patrick; Goedicke, Andreas

2018-05-01

Respiratory motion, which typically cannot simply be suspended during PET image acquisition, affects lesions' detection and quantitative accuracy inside or in close vicinity to the lungs. Some motion compensation techniques address this issue via pre-sorting ("binning") of the acquired PET data into a set of temporal gates, where each gate is assumed to be minimally affected by respiratory motion. Tracking respiratory motion is typically realized using dedicated hardware (e.g. using respiratory belts and digital cameras). Extracting respiratory signalsdirectly from the acquired PET data simplifies the clinical workflow as it avoids to handle additional signal measurement equipment. We introduce a new data-driven method "Combined Local Motion Detection" (CLMD). It uses the Time-of-Flight (TOF) information provided by state-of-the-art PET scanners in order to enable real-time respiratory signal extraction without additional hardware resources. CLMD applies center-of-mass detection in overlapping regions based on simple back-positioned TOF event sets acquired in short time frames. Following a signal filtering and quality-based pre-selection step, the remaining extracted individual position information over time is then combined to generate a global respiratory signal. The method is evaluated using 7 measured FDG studies from single and multiple scan positions of the thorax region, and it is compared to other software-based methods regarding quantitative accuracy and statistical noise stability. Correlation coefficients around 90% between the reference and the extracted signal have been found for those PET scans where motion affected features such as tumors or hot regions were present in the PET field-of-view. For PET scans with a quarter of typically applied radiotracer doses, the CLMD method still provides similar high correlation coefficients which indicates its robustness to noise. Each CLMD processing needed less than 0.4s in total on a standard multi-core CPU and thus provides a robust and accurate approach enabling real-time processing capabilities using standard PC hardware. © 2018 Institute of Physics and Engineering in Medicine.

Real-time fMRI processing with physiological noise correction - Comparison with off-line analysis.

PubMed

Misaki, Masaya; Barzigar, Nafise; Zotev, Vadim; Phillips, Raquel; Cheng, Samuel; Bodurka, Jerzy

2015-12-30

While applications of real-time functional magnetic resonance imaging (rtfMRI) are growing rapidly, there are still limitations in real-time data processing compared to off-line analysis. We developed a proof-of-concept real-time fMRI processing (rtfMRIp) system utilizing a personal computer (PC) with a dedicated graphic processing unit (GPU) to demonstrate that it is now possible to perform intensive whole-brain fMRI data processing in real-time. The rtfMRIp performs slice-timing correction, motion correction, spatial smoothing, signal scaling, and general linear model (GLM) analysis with multiple noise regressors including physiological noise modeled with cardiac (RETROICOR) and respiration volume per time (RVT). The whole-brain data analysis with more than 100,000voxels and more than 250volumes is completed in less than 300ms, much faster than the time required to acquire the fMRI volume. Real-time processing implementation cannot be identical to off-line analysis when time-course information is used, such as in slice-timing correction, signal scaling, and GLM. We verified that reduced slice-timing correction for real-time analysis had comparable output with off-line analysis. The real-time GLM analysis, however, showed over-fitting when the number of sampled volumes was small. Our system implemented real-time RETROICOR and RVT physiological noise corrections for the first time and it is capable of processing these steps on all available data at a given time, without need for recursive algorithms. Comprehensive data processing in rtfMRI is possible with a PC, while the number of samples should be considered in real-time GLM. Copyright © 2015 Elsevier B.V. All rights reserved.

THOR Field and Wave Processor - FWP

NASA Astrophysics Data System (ADS)

Soucek, Jan; Rothkaehl, Hanna; Balikhin, Michael; Zaslavsky, Arnaud; Nakamura, Rumi; Khotyaintsev, Yuri; Uhlir, Ludek; Lan, Radek; Yearby, Keith; Morawski, Marek; Winkler, Marek

2016-04-01

If selected, Turbulence Heating ObserveR (THOR) will become the first mission ever flown in space dedicated to plasma turbulence. The Fields and Waves Processor (FWP) is an integrated electronics unit for all electromagnetic field measurements performed by THOR. FWP will interface with all fields sensors: electric field antennas of the EFI instrument, the MAG fluxgate magnetometer and search-coil magnetometer (SCM) and perform data digitization and on-board processing. FWP box will house multiple data acquisition sub-units and signal analyzers all sharing a common power supply and data processing unit and thus a single data and power interface to the spacecraft. Integrating all the electromagnetic field measurements in a single unit will improve the consistency of field measurement and accuracy of time synchronization. The feasibility of making highly sensitive electric and magnetic field measurements in space has been demonstrated by Cluster (among other spacecraft) and THOR instrumentation complemented by a thorough electromagnetic cleanliness program will further improve on this heritage. Taking advantage of the capabilities of modern electronics, FWP will provide simultaneous synchronized waveform and spectral data products at high time resolution from the numerous THOR sensors, taking advantage of the large telemetry bandwidth of THOR. FWP will also implement a plasma a resonance sounder and a digital plasma quasi-thermal noise analyzer designed to provide high cadence measurements of plasma density and temperature complementary to data from particle instruments. FWP will be interfaced with the particle instrument data processing unit (PPU) via a dedicated digital link which will enable performing on board correlation between waves and particles, quantifying the transfer of energy between waves and particles. The FWP instrument shall be designed and built by an international consortium of scientific institutes from Czech Republic, Poland, France, UK, Sweden and Austria.

Bi-axial Vibration Energy Harvesting

DTIC Science & Technology

2012-07-01

included early dedicated portable signal averaging equipment, Nomad, CT4 and F18 fatigue test control systems and some field trials. Currently he is...and repairs to acoustically- fatigued structures. ____________________ ________________________________________________ UNCLASSIFIED...Physicists at the Tokyo Institute of Technology investigated various piezoceramic materials [20], developing lead zirconate titanate ( PZT ) in around 1952

Narrow-band filters for the lightning imager

NASA Astrophysics Data System (ADS)

Piegari, Angela; Di Sarcina, Ilaria; Grilli, Maria Luisa; Menchini, Francesca; Scaglione, Salvatore; Sytchkova, Anna; Zola, Danilo; Cuevas, Leticia P.

2017-11-01

The study of lightning phenomena will be carried out by a dedicated instrument, the lightning imager, that will make use of narrow-band transmission filters for separating the Oxygen emission lines in the clouds, from the background signal. The design, manufacturing and testing of these optical filters will be described here.

Investigation of BOLD fMRI Resonance Frequency Shifts and Quantitative Susceptibility Changes at 7 T

PubMed Central

Bianciardi, Marta; van Gelderen, Peter; Duyn, Jeff H.

2013-01-01

Although blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) experiments of brain activity generally rely on the magnitude of the signal, they also provide frequency information that can be derived from the phase of the signal. However, because of confounding effects of instrumental and physiological origin, BOLD related frequency information is difficult to extract and therefore rarely used. Here, we explored the use of high field (7 T) and dedicated signal processing methods to extract frequency information and use it to quantify and interpret blood oxygenation and blood volume changes. We found that optimized preprocessing improves detection of task-evoked and spontaneous changes in phase signals and resonance frequency shifts over large areas of the cortex with sensitivity comparable to that of magnitude signals. Moreover, our results suggest the feasibility of mapping BOLD quantitative susceptibility changes in at least part of the activated area and its largest draining veins. Comparison with magnitude data suggests that the observed susceptibility changes originate from neuronal activity through induced blood volume and oxygenation changes in pial and intracortical veins. Further, from frequency shifts and susceptibility values, we estimated that, relative to baseline, the fractional oxygen saturation in large vessels increased by 0.02–0.05 during stimulation, which is consistent to previously published estimates. Together, these findings demonstrate that valuable information can be derived from fMRI imaging of BOLD frequency shifts and quantitative susceptibility changes. PMID:23897623

Revision to dedicated short range communication roadside equipment specification – RSU 4.1.Bench Test Plan.

DOT National Transportation Integrated Search

2017-04-28

The document describes the overall process for evaluating Dedicated Short Range Communication (DSRC) Roadside Units (RSU) against USDOT RSU Specification 4.1 in preparation for field evaluation. The Test Cases contained in this document only evaluate...

Method and system to synchronize acoustic therapy with ultrasound imaging

NASA Technical Reports Server (NTRS)

Hossack, James (Inventor); Owen, Neil (Inventor); Bailey, Michael R. (Inventor)

2009-01-01

Interference in ultrasound imaging when used in connection with high intensity focused ultrasound (HIFU) is avoided by employing a synchronization signal to control the HIFU signal. Unless the timing of the HIFU transducer is controlled, its output will substantially overwhelm the signal produced by ultrasound imaging system and obscure the image it produces. The synchronization signal employed to control the HIFU transducer is obtained without requiring modification of the ultrasound imaging system. Signals corresponding to scattered ultrasound imaging waves are collected using either the HIFU transducer or a dedicated receiver. A synchronization processor manipulates the scattered ultrasound imaging signals to achieve the synchronization signal, which is then used to control the HIFU bursts so as to substantially reduce or eliminate HIFU interference in the ultrasound image. The synchronization processor can alternatively be implemented using a computing device or an application-specific circuit.

Distributed computing feasibility in a non-dedicated homogeneous distributed system

NASA Technical Reports Server (NTRS)

Leutenegger, Scott T.; Sun, Xian-He

1993-01-01

The low cost and availability of clusters of workstations have lead researchers to re-explore distributed computing using independent workstations. This approach may provide better cost/performance than tightly coupled multiprocessors. In practice, this approach often utilizes wasted cycles to run parallel jobs. The feasibility of such a non-dedicated parallel processing environment assuming workstation processes have preemptive priority over parallel tasks is addressed. An analytical model is developed to predict parallel job response times. Our model provides insight into how significantly workstation owner interference degrades parallel program performance. A new term task ratio, which relates the parallel task demand to the mean service demand of nonparallel workstation processes, is introduced. It was proposed that task ratio is a useful metric for determining how large the demand of a parallel applications must be in order to make efficient use of a non-dedicated distributed system.

Fully Digital Arrays of Silicon Photomultipliers (dSiPM) - a Scalable Alternative to Vacuum Photomultiplier Tubes (PMT)

NASA Astrophysics Data System (ADS)

Haemisch, York; Frach, Thomas; Degenhardt, Carsten; Thon, Andreas

Silicon Photomultipliers (SiPMs) have emerged as promising alternative to fast vacuum photomultiplier tubes (PMT). A fully digital implementation of the Silicon Photomultiplier (dSiPM) has been developed in order to overcome the deficiencies and limitations of the so far only analog SiPMs (aSiPMs). Our sensor is based on arrays of single photon avalanche photodiodes (SPADs) integrated in a standard CMOS process. Photons are detected directly by sensing the voltage at the SPAD anode using a dedicated cell electronics block next to each diode. This block also contains active quenching and recharge circuits as well as a one bit memory for the selective inhibit of detector cells. A balanced trigger network is used to propagate the trigger signal from all cells to the integrated time-to-digital converter. In consequence, photons are detected and counted as digital signals, thus making the sensor less susceptible to temperature variations and electronic noise. The integration with CMOS logic provides the added benefit of low power consumption and possible integration of data post-processing directly in the sensor. In this overview paper, we discuss the sensor architecture together with its characteristics with a focus on scalability and practicability aspects for applications in medical imaging, high energy- and astrophysics.

Low-cost extrapolation method for maximal LTE radio base station exposure estimation: test and validation.

PubMed

Verloock, Leen; Joseph, Wout; Gati, Azeddine; Varsier, Nadège; Flach, Björn; Wiart, Joe; Martens, Luc

2013-06-01

An experimental validation of a low-cost method for extrapolation and estimation of the maximal electromagnetic-field exposure from long-term evolution (LTE) radio base station installations are presented. No knowledge on downlink band occupation or service characteristics is required for the low-cost method. The method is applicable in situ. It only requires a basic spectrum analyser with appropriate field probes without the need of expensive dedicated LTE decoders. The method is validated both in laboratory and in situ, for a single-input single-output antenna LTE system and a 2×2 multiple-input multiple-output system, with low deviations in comparison with signals measured using dedicated LTE decoders.

Particle dark matter: A multimessenger endeavour

NASA Astrophysics Data System (ADS)

Regis, M.

2017-01-01

The search for dark matter (DM) as a new, yet undiscovered, particle is explored through a complex host of different signals, from collider to direct and indirect searches. A special focus is dedicated to the latter ones, covering the full electromagnetic spectrum (from radio to gamma-rays), charged cosmic-rays and neutrinos. The expected DM signals are by definition faint, but the possibility to exploit a wide-field investigation offers promising prospects. In this brief review, I summarize the state-of-the-art in the search for particle DM signals, exploring some new ideas that are emerging in the effort of the scientific community to understand the elusive nature of DM.

Stabilisation problem in biaxial platform

NASA Astrophysics Data System (ADS)

Lindner, Tymoteusz; Rybarczyk, Dominik; Wyrwał, Daniel

2016-12-01

The article describes investigation of rolling ball stabilization problem on a biaxial platform. The aim of the control system proposed here is to stabilize ball moving on a plane in equilibrium point. The authors proposed a control algorithm based on cascade PID and they compared it with another control method. The article shows the results of the accuracy of ball stabilization and influence of applied filter on the signal waveform. The application used to detect the ball position measured by digital camera has been written using a cross platform .Net wrapper to the OpenCV image processing library - EmguCV. The authors used the bipolar stepper motor with dedicated electronic controller. The data between the computer and the designed controller are sent with use of the RS232 standard. The control stand is based on ATmega series microcontroller.

Optimized 31P MRS in the human brain at 7 T with a dedicated RF coil setup

PubMed Central

van de Bank, Bart L.; Orzada, Stephan; Smits, Frits; Lagemaat, Miriam W.; Rodgers, Christopher T.; Bitz, Andreas K.

2015-01-01

The design and construction of a dedicated RF coil setup for human brain imaging (1H) and spectroscopy (31P) at ultra‐high magnetic field strength (7 T) is presented. The setup is optimized for signal handling at the resonance frequencies for 1H (297.2 MHz) and 31P (120.3 MHz). It consists of an eight‐channel 1H transmit–receive head coil with multi‐transmit capabilities, and an insertable, actively detunable 31P birdcage (transmit–receive and transmit only), which can be combined with a seven‐channel receive‐only 31P array. The setup enables anatomical imaging and 31P studies without removal of the coil or the patient. By separating transmit and receive channels and by optimized addition of array signals with whitened singular value decomposition we can obtain a sevenfold increase in SNR of 31P signals in the occipital lobe of the human brain compared with the birdcage alone. These signals can be further enhanced by 30 ± 9% using the nuclear Overhauser effect by B 1‐shimmed low‐power irradiation of water protons. Together, these features enable acquisition of 31P MRSI at high spatial resolutions (3.0 cm3 voxel) in the occipital lobe of the human brain in clinically acceptable scan times (~15 min). © 2015 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd. PMID:26492089

Feasibility of in utero telemetric fetal ECG monitoring in a lamb model.

PubMed

Hermans, Bart; Lewi, Liesbeth; Jani, Jacques; De Buck, Frederik; Deprest, Jan; Puers, Robert

2008-01-01

If fetal ECG (fECG) devices could be miniaturized sufficiently, one could consider their implantation at the time of fetal surgery to allow permanent monitoring of the fetus and timely intervention in the viable period. We set up an experiment to evaluate the feasibility of in utero direct fECG monitoring and telemetric transmission using a small implantable device in a lamb model. A 2-lead miniature ECG sensor (volume 1.9 cm(3); weight 3.9 g) was subcutaneously implanted in 2 fetal lambs at 122 days gestation (range 119-125; term 145 days). The ECG sensor can continuously register and transmit fECG. The signal is captured by an external receiving antenna taped to the maternal abdominal wall. We developed dedicated software running on a commercial laptop for on-line analysis of the transmitted fECG signal. This was a noninterventional study, i.e. daily readings of the fECG signal were done without clinical consequences to the observations. fECG could be successfully registered, transmitted by telemetry and analyzed from the moment of implantation till term birth in one case (24 days). In the second case, unexplained in utero fetal death occurred 12 days after implantation. In this subject, agonal fECG changes were recorded. An implanted miniature (<2 ml) ECG sensor can be used to retrieve, process and transmit continuously a qualitative fECG signal in third-trimester fetal lambs. The telemetric signal could be picked up by an external antenna located within a 20-cm range. In this experiment, this was achieved through taping the external receiver to the maternal abdomen. Any acquired signal could be transmitted to a commercially available laptop that could perform on-line analysis of the signal. (c) 2008 S. Karger AG, Basel.

Added value products for imaging remote sensing by processing actual GNSS reflectometry delay doppler maps

NASA Astrophysics Data System (ADS)

Schiavulli, Domenico; Frappart, Frédéric; Ramilien, Guillaume; Darrozes, José; Nunziata, Ferdinando; Migliaccio, Maurizio

2016-04-01

Global Navigation Satellite System Reflectometry (GNSS-R) is an innovative and promising tool for remote sensing. It is based on the exploitation of GNSS signals reflected off Earth's surface as signals of opportunity to infer geophysical information of the reflecting surface. The main advantages of GNSS-R with respect dedicated sensors are: the unprecedented spatial-temporal coverage due to the availability of a great amount of transmitting satellite, e.g. GPS, Galileo, Glonass, etc…, long term GNSS mission life and cost effectiveness. In fact only a simple receiver is needed. In the last years several works demonstrated the meaningful of this technique in several Earth Observation applications. All these applications presented results obtained by using a receiver mounted on an aircraft or on a fixed platform. Moreover, space borne missions have been launched or are planned: UK-DMC, TechDemoSat-1 (TDS-1), NASA CYGNSS, Geros ISS. Practically, GNSS-R can be seen as a bistatic radar system where the GNSS satellites continuously transmit the L-band all-weather night-and-day signals that are reflected off a surface, called Glistening Zone (GZ), and a receiver measures the scattered microwave signals in terms of Delay-Doppler maps (DDMs) or delay waveforms. These two products have been widely studied in the literature to extract compact parameters for different remote sensing applications. However, products measured in the Delay Doppler (DD) domain are not able to provide any spatial information of the scattering scene. This could represent a drawback for applications related to imaging remote sensing, e.g. target detection, sea/land and sea/ice transition, oil spill detection, etc…. To overcome these limitations some deconvolution techniques have been proposed in the state of the art aiming at the reconstruction of a radar image of the observed scene by processing the measured DDMs. These techniques have been tested on DDMs related to simulated marine scenario including areas with different wind speed, oil spill, non-homogeneous area and cyclone. In this work a deconvolution technique based on the 2-D Truncated Singular Value Decomposition (TSVD) approach is used to process, for the first time, a real DDM measured by the TDS-1 mission to generate a radar image of the observed scene. The considered DDMs are related to marine scenario including non-homogenous area, i.e. sea/land and sea/ice transition. These non-homogeneous area provide a strong scattering contribution in the DD domain but it is not possible to extract any other information by analyzing the DDM. In the other hand, after the 2-D TSVD technique application a radar image of the observed scenario is provided where the transition between sea and non-homogeneous elements is reconstructed and well located in the spatial domain. Finally, in this work we demonstrate the soundness of the proposed approach able to provide an added value product for imaging remote sensing to improve/complement dedicated sensors.

Mirror mechanism and dedicated circuits are the scaffold for mirroring processes.

PubMed

Fogassi, Leonardo

2014-04-01

In the past decade many studies have demonstrated the existence of a mirror mechanism that matches the sensory representation of a biological stimulus with its somatomotor and visceromotor representation. This mechanism, likely phylogenetically very old, explains several types of mirroring behaviours, at different levels of complexity. The presence in primates of dedicated neuroanatomical pathways for specific sensorimotor integrations processes implies, at least in the primate lineage, a hard-wired mirror mechanism for social cognitive functions.

Design and characterization of the ePix10k: a high dynamic range integrating pixel ASIC for LCLS detectors

NASA Astrophysics Data System (ADS)

Caragiulo, P.; Dragone, A.; Markovic, B.; Herbst, R.; Nishimura, K.; Reese, B.; Herrmann, S.; Hart, P.; Blaj, G.; Segal, J.; Tomada, A.; Hasi, J.; Carini, G.; Kenney, C.; Haller, G.

2015-05-01

ePix10k is a variant of a novel class of integrating pixel ASICs architectures optimized for the processing of signals in second generation LINAC Coherent Light Source (LCLS) X-Ray cameras. The ASIC is optimized for high dynamic range application requiring high spatial resolution and fast frame rates. ePix ASICs are based on a common platform composed of a random access analog matrix of pixel with global shutter, fast parallel column readout, and dedicated sigma-delta analog to digital converters per column. The ePix10k variant has 100um×100um pixels arranged in a 176×192 matrix, a resolution of 140e- r.m.s. and a signal range of 3.5pC (10k photons at 8keV). In its final version it will be able to sustain a frame rate of 2kHz. A first prototype has been fabricated and characterized. Performance in terms of noise, linearity, uniformity, cross-talk, together with preliminary measurements with bump bonded sensors are reported here.

Efficient nonlinear equalizer for intra-channel nonlinearity compensation for next generation agile and dynamically reconfigurable optical networks.

PubMed

Malekiha, Mahdi; Tselniker, Igor; Plant, David V

2016-02-22

In this work, we propose and experimentally demonstrate a novel low-complexity technique for fiber nonlinearity compensation. We achieved a transmission distance of 2818 km for a 32-GBaud dual-polarization 16QAM signal. For efficient implantation, and to facilitate integration with conventional digital signal processing (DSP) approaches, we independently compensate fiber nonlinearities after linear impairment equalization. Therefore this algorithm can be easily implemented in currently deployed transmission systems after using linear DSP. The proposed equalizer operates at one sample per symbol and requires only one computation step. The structure of the algorithm is based on a first-order perturbation model with quantized perturbation coefficients. Also, it does not require any prior calculation or detailed knowledge of the transmission system. We identified common symmetries between perturbation coefficients to avoid duplicate and unnecessary operations. In addition, we use only a few adaptive filter coefficients by grouping multiple nonlinear terms and dedicating only one adaptive nonlinear filter coefficient to each group. Finally, the complexity of the proposed algorithm is lower than previously studied nonlinear equalizers by more than one order of magnitude.

Biochemical Frequency Control by Synchronisation of Coupled Repressilators: An In Silico Study of Modules for Circadian Clock Systems

PubMed Central

Hinze, Thomas; Schumann, Mathias; Bodenstein, Christian; Heiland, Ines; Schuster, Stefan

2011-01-01

Exploration of chronobiological systems emerges as a growing research field within bioinformatics focusing on various applications in medicine, agriculture, and material sciences. From a systems biological perspective, the question arises whether biological control systems for regulation of oscillatory signals and their technical counterparts utilise similar mechanisms. If so, modelling approaches and parameterisation adopted from building blocks can help to identify general components for frequency control in circadian clocks along with gaining insight into mechanisms of clock synchronisation to external stimuli like the daily rhythm of sunlight and darkness. Phase-locked loops could be an interesting candidate in this context. Both, biology and engineering, can benefit from a unified view resulting from systems modularisation. In a first experimental study, we analyse a model of coupled repressilators. We demonstrate its ability to synchronise clock signals in a monofrequential manner. Several oscillators initially deviate in phase difference and frequency with respect to explicit reaction and diffusion rates. Accordingly, the duration of the synchronisation process depends on dedicated reaction and diffusion parameters whose settings still lack to be sufficiently captured analytically. PMID:22046179

Strong tW scattering at the LHC

DOE PAGES

Dror, Jeff Asaf; Farina, Marco; Salvioni, Ennio; ...

2016-01-13

Deviations of the top electroweak couplings from their Standard Model values imply that certain amplitudes for the scattering of third generation fermions and longitudinally polarized vector bosons or Higgses diverge quadratically with momenta. This high-energy growth is a genuine signal of models where the top quark is strongly coupled to the sector responsible for electroweak symmetry breaking. We propose to profit from the high energies accessible at the LHC to enhance the sensitivity to non-standard top-Z couplings, which are currently very weakly constrained. To demonstrate the effectiveness of the approach, we perform a detailed analysis of tW → tW scattering, which can be probed at the LHC via pp→more » $$t\\bar{t}$$Wj. By recasting a CMS analysis at 8 TeV, we derive the strongest direct bounds to date on the Ztt couplings. We also design a dedicated search at 13 TeV that exploits the distinctive features of the $$t\\bar{t}$$Wj signal. Lastly, we present other scattering processes in the same class that could provide further tests of the top-Higgs sector.« less

Culture shapes 7-month-olds' perceptual strategies in discriminating facial expressions of emotion.

PubMed

Geangu, Elena; Ichikawa, Hiroko; Lao, Junpeng; Kanazawa, So; Yamaguchi, Masami K; Caldara, Roberto; Turati, Chiara

2016-07-25

Emotional facial expressions are thought to have evolved because they play a crucial role in species' survival. From infancy, humans develop dedicated neural circuits [1] to exhibit and recognize a variety of facial expressions [2]. But there is increasing evidence that culture specifies when and how certain emotions can be expressed - social norms - and that the mature perceptual mechanisms used to transmit and decode the visual information from emotional signals differ between Western and Eastern adults [3-5]. Specifically, the mouth is more informative for transmitting emotional signals in Westerners and the eye region for Easterners [4], generating culture-specific fixation biases towards these features [5]. During development, it is recognized that cultural differences can be observed at the level of emotional reactivity and regulation [6], and to the culturally dominant modes of attention [7]. Nonetheless, to our knowledge no study has explored whether culture shapes the processing of facial emotional signals early in development. The data we report here show that, by 7 months, infants from both cultures visually discriminate facial expressions of emotion by relying on culturally distinct fixation strategies, resembling those used by the adults from the environment in which they develop [5]. Copyright © 2016 Elsevier Ltd. All rights reserved.

Real-time synchronization of wireless sensor network by 1-PPS signal

NASA Astrophysics Data System (ADS)

Giammarini, Marco; Pieralisi, Marco; Isidori, Daniela; Concettoni, Enrico; Cristalli, Cristina; Fioravanti, Matteo

2015-05-01

The use of wireless sensor networks with different nodes is desirable in a smart environment, because the network setting up and installation on preexisting structures can be done without a fixed cabled infrastructure. The flexibility of the monitoring system is fundamental where the use of a considerable quantity of cables could compromise the normal exercise, could affect the quality of acquired signal and finally increase the cost of the materials and installation. The network is composed of several intelligent "nodes", which acquires data from different kind of sensors, and then store or transmit them to a central elaboration unit. The synchronization of data acquisition is the core of the real-time wireless sensor network (WSN). In this paper, we present a comparison between different methods proposed by literature for the real-time acquisition in a WSN and finally we present our solution based on 1-Pulse-Per-Second (1-PPS) signal generated by GPS systems. The sensor node developed is a small-embedded system based on ARM microcontroller that manages the acquisition, the timing and the post-processing of the data. The communications between the sensors and the master based on IEEE 802.15.4 protocol and managed by dedicated software. Finally, we present the preliminary results obtained on a 3 floor building simulator with the wireless sensors system developed.

Design of a Multi-Channel Front-End Readout ASIC With Low Noise and Large Dynamic Input Range for APD-Based PET Imaging

NASA Astrophysics Data System (ADS)

Fang, X. C.; Hu-Guo, Ch.; Ollivier-Henry, N.; Brasse, D.; Hu, Y.

2010-06-01

This paper represents the design of a low-noise, wide band multi-channel readout integrated circuit (IC) used as front end readout electronics of avalanche photo diodes (APD) dedicated to a small animal positron emission tomography (PET) system. The first ten-channel prototype chip (APD-Chip) of the analog parts has been designed and fabricated in a 0.35 μm CMOS process. Every channel of the APD_Chip includes a charge-sensitive preamplifier (CSA), a CR-(RC)2 shaper, and an analog buffer. In a channel, the CSA reads charge signals (10 bits dynamic range) from an APD array having 10 pF of capacitance per pixel. A linearized degenerated differential pair which ensures high linearity in all dynamical range is used as the high feedback resistor for preventing pile up of signals. The designed CSA has the capability of compensating automatically up to 200 nA leakage current from the detector. The CR-(RC)2 shaper filters and shapes the output signal of the CSA. An equivalent input noise charge obtained from test is 275 e -+ 10 e-/pF. In this paper the prototype is presented for both its theoretical analysis and its test results.

A passive chevron replicator

NASA Technical Reports Server (NTRS)

Oeffinger, T. R.; Tocci, L. R.

1977-01-01

Instrument design provides replicate function between device storage area and guardrail detector in order that nondestructive read-out of memory can be achieved. Use of guardrail detectors in magnetic domain (bubble) circuits is proposed method of increasing detector signal output by increasing detector size without dedicating an excessive amount of device chip area to detector portion.

Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains.

PubMed

Bücherl, Christoph A; Jarsch, Iris K; Schudoma, Christian; Segonzac, Cécile; Mbengue, Malick; Robatzek, Silke; MacLean, Daniel; Ott, Thomas; Zipfel, Cyril

2017-03-06

Cell surface receptors govern a multitude of signalling pathways in multicellular organisms. In plants, prominent examples are the receptor kinases FLS2 and BRI1, which activate immunity and steroid-mediated growth, respectively. Intriguingly, despite inducing distinct signalling outputs, both receptors employ common downstream signalling components, which exist in plasma membrane (PM)-localised protein complexes. An important question is thus how these receptor complexes maintain signalling specificity. Live-cell imaging revealed that FLS2 and BRI1 form PM nanoclusters. Using single-particle tracking we could discriminate both cluster populations and we observed spatiotemporal separation between immune and growth signalling platforms. This finding was confirmed by visualising FLS2 and BRI1 within distinct PM nanodomains marked by specific remorin proteins and differential co-localisation with the cytoskeleton. Our results thus suggest that signalling specificity between these pathways may be explained by the spatial separation of FLS2 and BRI1 with their associated signalling components within dedicated PM nanodomains.

Classification of cognitive systems dedicated to data sharing

NASA Astrophysics Data System (ADS)

Ogiela, Lidia; Ogiela, Marek R.

2017-08-01

In this paper will be presented classification of new cognitive information systems dedicated to cryptographic data splitting and sharing processes. Cognitive processes of semantic data analysis and interpretation, will be used to describe new classes of intelligent information and vision systems. In addition, cryptographic data splitting algorithms and cryptographic threshold schemes will be used to improve processes of secure and efficient information management with application of such cognitive systems. The utility of the proposed cognitive sharing procedures and distributed data sharing algorithms will be also presented. A few possible application of cognitive approaches for visual information management and encryption will be also described.

GNSS Radio Occultation Observations as a data source for Ionospheric Assimilation: COSMIC-1 & COSMIC-2

NASA Astrophysics Data System (ADS)

Yue, X.; Schreiner, W. S.; Kuo, Y. H.

2014-12-01

Since the pioneer GPS/MET mission, low Earth orbit (LEO) based global navigation satellite system (GNSS) Radio Occultation (RO) technique has been a powerful technique in ionosphere monitoring. After that, many LEO satellites were launched with RO payload, include: CHAMP , GRACE, SAC-C/D, COSMIC, C/NOFS, Metop-A/B, TerraSAR-X/TanDEM-X, and etc. COSMIC was the first constellation of satellites dedicated primarily to RO and delivering RO data in near real time. Currently in UCAR CDAAC, we process most of these missions' RO data for the community. Due to the success of COSMIC mission, a follow on mission called COSMIC-2 will be launched in 2016 and 2018, respectively. The COSMIC-2 RO data will be 4-6 times of COSMIC due to the doubled satellite and GNSS signals. In this paper we will describe: (1) Data process and quality in UCAR/CDAAC; (2) Ionospheric data assimilation results based on COSMIC data; (3) OSSE study for COSMIC-2.

Low cost open data acquisition system for biomedical applications

NASA Astrophysics Data System (ADS)

Zabolotny, Wojciech M.; Laniewski-Wollk, Przemyslaw; Zaworski, Wojciech

2005-09-01

In the biomedical applications it is often necessary to collect measurement data from different devices. It is relatively easy, if the devices are equipped with a MIB or Ethernet interface, however often they feature only the asynchronous serial link, and sometimes the measured values are available only as the analog signals. The system presented in the paper is a low cost alternative to commercially available data acquisition systems. The hardware and software architecture of the system is fully open, so it is possible to customize it for particular needs. The presented system offers various possibilities to connect it to the computer based data processing unit - e.g. using the USB or Ethernet ports. Both interfaces allow also to use many such systems in parallel to increase amount of serial and analog inputs. The open source software used in the system makes possible to process the acquired data with standard tools like MATLAB, Scilab or Octave, or with a dedicated, user supplied application.

Learning target masks in infrared linescan imagery

NASA Astrophysics Data System (ADS)

Fechner, Thomas; Rockinger, Oliver; Vogler, Axel; Knappe, Peter

1997-04-01

In this paper we propose a neural network based method for the automatic detection of ground targets in airborne infrared linescan imagery. Instead of using a dedicated feature extraction stage followed by a classification procedure, we propose the following three step scheme: In the first step of the recognition process, the input image is decomposed into its pyramid representation, thus obtaining a multiresolution signal representation. At the lowest three levels of the Laplacian pyramid a neural network filter of moderate size is trained to indicate the target location. The last step consists of a fusion process of the several neural network filters to obtain the final result. To perform this fusion we use a belief network to combine the various filter outputs in a statistical meaningful way. In addition, the belief network allows the integration of further knowledge about the image domain. By applying this multiresolution recognition scheme, we obtain a nearly scale- and rotational invariant target recognition with a significantly decreased false alarm rate compared with a single resolution target recognition scheme.

Sex-specific processing of social cues in the medial amygdala

PubMed Central

Bergan, Joseph F; Ben-Shaul, Yoram; Dulac, Catherine

2014-01-01

Animal–animal recognition within, and across species, is essential for predator avoidance and social interactions. Despite its essential role in orchestrating responses to animal cues, basic principles of information processing by the vomeronasal system are still unknown. The medial amygdala (MeA) occupies a central position in the vomeronasal pathway, upstream of hypothalamic centers dedicated to defensive and social responses. We have characterized sensory responses in the mouse MeA and uncovered emergent properties that shed new light onto the transformation of vomeronasal information into sex- and species-specific responses. In particular, we show that the MeA displays a degree of stimulus selectivity and a striking sexually dimorphic sensory representation that are not observed in the upstream relay of the accessory olfactory bulb (AOB). Furthermore, our results demonstrate that the development of sexually dimorphic circuits in the MeA requires steroid signaling near the time of puberty to organize the functional representation of sensory stimuli. DOI: http://dx.doi.org/10.7554/eLife.02743.001 PMID:24894465

Sources of Safety Data and Statistical Strategies for Design and Analysis: Transforming Data Into Evidence.

PubMed

Ma, Haijun; Russek-Cohen, Estelle; Izem, Rima; Marchenko, Olga V; Jiang, Qi

2018-03-01

Safety evaluation is a key aspect of medical product development. It is a continual and iterative process requiring thorough thinking, and dedicated time and resources. In this article, we discuss how safety data are transformed into evidence to establish and refine the safety profile of a medical product, and how the focus of safety evaluation, data sources, and statistical methods change throughout a medical product's life cycle. Some challenges and statistical strategies for medical product safety evaluation are discussed. Examples of safety issues identified in different periods, that is, premarketing and postmarketing, are discussed to illustrate how different sources are used in the safety signal identification and the iterative process of safety assessment. The examples highlighted range from commonly used pediatric vaccine given to healthy children to medical products primarily used to treat a medical condition in adults. These case studies illustrate that different products may require different approaches, and once a signal is discovered, it could impact future safety assessments. Many challenges still remain in this area despite advances in methodologies, infrastructure, public awareness, international harmonization, and regulatory enforcement. Innovations in safety assessment methodologies are pressing in order to make the medical product development process more efficient and effective, and the assessment of medical product marketing approval more streamlined and structured. Health care payers, providers, and patients may have different perspectives when weighing in on clinical, financial and personal needs when therapies are being evaluated.

Envelope contributions to the representation of interaural time difference in the forebrain of barn owls.

PubMed

Tellers, Philipp; Lehmann, Jessica; Führ, Hartmut; Wagner, Hermann

2017-09-01

Birds and mammals use the interaural time difference (ITD) for azimuthal sound localization. While barn owls can use the ITD of the stimulus carrier frequency over nearly their entire hearing range, mammals have to utilize the ITD of the stimulus envelope to extend the upper frequency limit of ITD-based sound localization. ITD is computed and processed in a dedicated neural circuit that consists of two pathways. In the barn owl, ITD representation is more complex in the forebrain than in the midbrain pathway because of the combination of two inputs that represent different ITDs. We speculated that one of the two inputs includes an envelope contribution. To estimate the envelope contribution, we recorded ITD response functions for correlated and anticorrelated noise stimuli in the barn owl's auditory arcopallium. Our findings indicate that barn owls, like mammals, represent both carrier and envelope ITDs of overlapping frequency ranges, supporting the hypothesis that carrier and envelope ITD-based localization are complementary beyond a mere extension of the upper frequency limit. NEW & NOTEWORTHY The results presented in this study show for the first time that the barn owl is able to extract and represent the interaural time difference (ITD) information conveyed by the envelope of a broadband acoustic signal. Like mammals, the barn owl extracts the ITD of the envelope and the carrier of a signal from the same frequency range. These results are of general interest, since they reinforce a trend found in neural signal processing across different species. Copyright © 2017 the American Physiological Society.

Nuclear Safety via Commercial Grade Dedication - Hitting the Right Target - 12163

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kindred, Greg

2012-07-01

S.A.Technology has developed and implemented a highly effective Commercial Grade Dedication program that has been used to qualify a variety of equipment to the rigorous requirements of ASTM NQA-1. In specific cases, S.A.Technology personnel have worked closely with clients to develop complex Commercial Grade Dedication plans that satisfy the scrutiny of the US Department of Energy. These projects have been as simple as Passive Mechanical systems, and as complicated as Active Mechanical and Electrical systems. S.A.Technology's Commercial Grade Dedication plans have even been used as presentation materials to a client's internal departments encompassing Engineering, Quality and Procurement. This is themore » new target of today's CGD: exposing the reasoning behind the dedication process. Previously, only test and inspection results were expected. Today's CGD now needs to show how the decisions presented are the right decisions to make. We must be willing to undergo the process of learning how each new piece of equipment is affected by the system it is placed into, as well as understanding how that equipment can affect the system itself. It is a much more complicated and time-consuming endeavor to undertake. On top of it all, we must be able to voice those discoveries and rationalizations in a clear and concise manner. Unless we effectively communicate our intentions to the reader, we will not be understood. If researched correctly and presented properly, today's Commercial Grade Dedication plans will answer the appropriate questions before they are asked. (authors)« less

Seismic signal processing on heterogeneous supercomputers

NASA Astrophysics Data System (ADS)

Gokhberg, Alexey; Ermert, Laura; Fichtner, Andreas

2015-04-01

The processing of seismic signals - including the correlation of massive ambient noise data sets - represents an important part of a wide range of seismological applications. It is characterized by large data volumes as well as high computational input/output intensity. Development of efficient approaches towards seismic signal processing on emerging high performance computing systems is therefore essential. Heterogeneous supercomputing systems introduced in the recent years provide numerous computing nodes interconnected via high throughput networks, every node containing a mix of processing elements of different architectures, like several sequential processor cores and one or a few graphical processing units (GPU) serving as accelerators. A typical representative of such computing systems is "Piz Daint", a supercomputer of the Cray XC 30 family operated by the Swiss National Supercomputing Center (CSCS), which we used in this research. Heterogeneous supercomputers provide an opportunity for manifold application performance increase and are more energy-efficient, however they have much higher hardware complexity and are therefore much more difficult to program. The programming effort may be substantially reduced by the introduction of modular libraries of software components that can be reused for a wide class of seismology applications. The ultimate goal of this research is design of a prototype for such library suitable for implementing various seismic signal processing applications on heterogeneous systems. As a representative use case we have chosen an ambient noise correlation application. Ambient noise interferometry has developed into one of the most powerful tools to image and monitor the Earth's interior. Future applications will require the extraction of increasingly small details from noise recordings. To meet this demand, more advanced correlation techniques combined with very large data volumes are needed. This poses new computational problems that require dedicated HPC solutions. The chosen application is using a wide range of common signal processing methods, which include various IIR filter designs, amplitude and phase correlation, computing the analytic signal, and discrete Fourier transforms. Furthermore, various processing methods specific for seismology, like rotation of seismic traces, are used. Efficient implementation of all these methods on the GPU-accelerated systems represents several challenges. In particular, it requires a careful distribution of work between the sequential processors and accelerators. Furthermore, since the application is designed to process very large volumes of data, special attention had to be paid to the efficient use of the available memory and networking hardware resources in order to reduce intensity of data input and output. In our contribution we will explain the software architecture as well as principal engineering decisions used to address these challenges. We will also describe the programming model based on C++ and CUDA that we used to develop the software. Finally, we will demonstrate performance improvements achieved by using the heterogeneous computing architecture. This work was supported by a grant from the Swiss National Supercomputing Centre (CSCS) under project ID d26.

Spacelab payload accommodation handbook. Appendix A: Avionics interface definition

NASA Technical Reports Server (NTRS)

1978-01-01

The Spacelab side of the electrical interface between Spacelab subsystem equipment and experiments is presented. The electrical hardware which interfaces with the experiments is defined and the signal/load characteristics are stated. Major subsystems considered include: electrical power and distribution; command and data management subsystem; orbiter avionics via dedicated connectors of Spacelab; and electrical ground support equipment.

Hierarchical classification strategy for Phenotype extraction from epidermal growth factor receptor endocytosis screening.

PubMed

Cao, Lu; Graauw, Marjo de; Yan, Kuan; Winkel, Leah; Verbeek, Fons J

2016-05-03

Endocytosis is regarded as a mechanism of attenuating the epidermal growth factor receptor (EGFR) signaling and of receptor degradation. There is increasing evidence becoming available showing that breast cancer progression is associated with a defect in EGFR endocytosis. In order to find related Ribonucleic acid (RNA) regulators in this process, high-throughput imaging with fluorescent markers is used to visualize the complex EGFR endocytosis process. Subsequently a dedicated automatic image and data analysis system is developed and applied to extract the phenotype measurement and distinguish different developmental episodes from a huge amount of images acquired through high-throughput imaging. For the image analysis, a phenotype measurement quantifies the important image information into distinct features or measurements. Therefore, the manner in which prominent measurements are chosen to represent the dynamics of the EGFR process becomes a crucial step for the identification of the phenotype. In the subsequent data analysis, classification is used to categorize each observation by making use of all prominent measurements obtained from image analysis. Therefore, a better construction for a classification strategy will support to raise the performance level in our image and data analysis system. In this paper, we illustrate an integrated analysis method for EGFR signalling through image analysis of microscopy images. Sophisticated wavelet-based texture measurements are used to obtain a good description of the characteristic stages in the EGFR signalling. A hierarchical classification strategy is designed to improve the recognition of phenotypic episodes of EGFR during endocytosis. Different strategies for normalization, feature selection and classification are evaluated. The results of performance assessment clearly demonstrate that our hierarchical classification scheme combined with a selected set of features provides a notable improvement in the temporal analysis of EGFR endocytosis. Moreover, it is shown that the addition of the wavelet-based texture features contributes to this improvement. Our workflow can be applied to drug discovery to analyze defected EGFR endocytosis processes.

Dressed for Sex: Red as a Female Sexual Signal in Humans

PubMed Central

Elliot, Andrew J.; Pazda, Adam D.

2012-01-01

Background In many non-human primate species, a display of red by a female serves as a sexual signal to attract male conspecifics. Red is associated with sex and romance in humans, and women convey their sexual interest to men through a variety of verbal, postural, and behavioral means. In the present research, we investigate whether female red ornamentation in non-human primates has a human analog, whereby women use a behavioral display of red to signal their sexual interest to men. Methodology/Principal Findings Three studies tested the hypothesis that women use red clothing to communicate sexual interest to men in profile pictures on dating websites. In Study 1, women who imagined being interested in casual sex were more likely to display red (but not other colors) on their anticipated web profile picture. In Study 2, women who indicated interest in casual sex were more likely to prominently display red (but not other colors) on their actual web profile picture. In Study 3, women on a website dedicated to facilitating casual sexual relationships were more likely to prominently exhibit red (but not other colors) than women on a website dedicated to facilitating marital relationships. Conclusions/Significance These results establish a provocative parallel between women and non-human female primates in red signal coloration in the mating game. This research shows, for the first time, a functional use of color in women's sexual self-presentation, and highlights the need to extend research on color beyond physics, physiology, and preference to psychological functioning. PMID:22514643

MR imaging of hand and wrist with a dedicated 0.1-T low-field imaging system.

PubMed

Gries, P; Constantinesco, A; Brunot, B; Facello, A

1991-01-01

We describe the first results of a new magnetic resonance imaging (MRI) system specially developed for hand and wrist imaging. The system uses a small resistive water-cooled magnet with a vertical magnetic field of 0.1 T in an air gap of 15 cm. The console is based on a microcomputer with a vector signal processor and an image-processing board. There is actually no Faraday cage. For the whole hand, the in-plane spatial resolution is less than 1 mm in the 128 x 128-pixels format for typical slice thicknesses of 3 to 5 mm. Solenoidal volume coils for fingers were developed, giving, in the same matrix format, an in-plane high spatial resolution of 0.22 mm for a typical slice thickness of 3 mm.

Learning physical descriptors for materials science by compressed sensing

NASA Astrophysics Data System (ADS)

Ghiringhelli, Luca M.; Vybiral, Jan; Ahmetcik, Emre; Ouyang, Runhai; Levchenko, Sergey V.; Draxl, Claudia; Scheffler, Matthias

2017-02-01

The availability of big data in materials science offers new routes for analyzing materials properties and functions and achieving scientific understanding. Finding structure in these data that is not directly visible by standard tools and exploitation of the scientific information requires new and dedicated methodology based on approaches from statistical learning, compressed sensing, and other recent methods from applied mathematics, computer science, statistics, signal processing, and information science. In this paper, we explain and demonstrate a compressed-sensing based methodology for feature selection, specifically for discovering physical descriptors, i.e., physical parameters that describe the material and its properties of interest, and associated equations that explicitly and quantitatively describe those relevant properties. As showcase application and proof of concept, we describe how to build a physical model for the quantitative prediction of the crystal structure of binary compound semiconductors.

Effective resolution concepts for lidar observations

NASA Astrophysics Data System (ADS)

Iarlori, M.; Madonna, F.; Rizi, V.; Trickl, T.; Amodeo, A.

2015-12-01

Since its establishment in 2000, EARLINET (European Aerosol Research Lidar NETwork) has provided, through its database, quantitative aerosol properties, such as aerosol backscatter and aerosol extinction coefficients, the latter only for stations able to retrieve it independently (from Raman or high-spectral-resolution lidars). These coefficients are stored in terms of vertical profiles, and the EARLINET database also includes the details of the range resolution of the vertical profiles. In fact, the algorithms used in the lidar data analysis often alter the spectral content of the data, mainly acting as low-pass filters to reduce the high-frequency noise. Data filtering is described by the digital signal processing (DSP) theory as a convolution sum: each filtered signal output at a given range is the result of a linear combination of several signal input data samples (relative to different ranges from the lidar receiver), and this could be seen as a loss of range resolution of the output signal. Low-pass filtering always introduces distortions in the lidar profile shape. Thus, both the removal of high frequency, i.e., the removal of details up to a certain spatial extension, and the spatial distortion produce a reduction of the range resolution. This paper discusses the determination of the effective resolution (ERes) of the vertical profiles of aerosol properties retrieved from lidar data. Large attention has been dedicated to providing an assessment of the impact of low-pass filtering on the effective range resolution in the retrieval procedure.

KENNEDY SPACE CENTER, FLA. - Center Director Jim Kennedy (right) presents a plaque to Conrad Nagel who organized the Spaceport Super Safety and Health Day at KSC, an annual event dedicated to reinforcing safe and healthful behaviors in the workforce. Nagel is chief of the Shuttle Project Office, Shuttle Processing.

NASA Image and Video Library

2003-10-15

KENNEDY SPACE CENTER, FLA. - Center Director Jim Kennedy (right) presents a plaque to Conrad Nagel who organized the Spaceport Super Safety and Health Day at KSC, an annual event dedicated to reinforcing safe and healthful behaviors in the workforce. Nagel is chief of the Shuttle Project Office, Shuttle Processing.

MULTIMERMAID: A dedicated multichannel seismic/weather/zoological float for monitoring of the oceans

NASA Astrophysics Data System (ADS)

Hello, Y. M.; Bonnieux, S.; Joubert, C.; Sukhovich, A.; Argentino, J.; Yegikyan, M.; Nolet, G.

2013-12-01

Delays of seismic P waves are used to make scans or 3D images of the variations in seismic wave speed in the Earth's interior using the techniques of seismic tomography. Observations of such delays are ubiquitous on the continents but rare in oceanic regions, mostly because of the large cost associated with deploying ocean-bottom seismometers. At the same time, several thousand free-drifting profiling floats measure the temperature, salinity and current of the upper 2000 m of the ocean in the Argo program, but are incapable to record and transmit seismic signals. Simons et al. (JGR, 2009) developed the idea to use such floats in order to compensate for the lack of seismic delay observations, especially in the southern hemisphere. We built and tested a prototype of such a seismological sensor using an Apex float from Teledyne Webb Research, a Rafos hydrophone, and electronics developed in collaboration with Osean, a small engineering firm in France. This `MERMAID', for `Mobile Earthquake Recorder in Marine Areas by Independent Divers', has concluded its final design stage and a fleet of 20 units is available for experiments. Since 2012, half of these floats have been deployed in the Mediterranean and in the South Indian Ocean. 10 more will be deployed early in 2014 near the Galapagos islands in the Pacific. Analysis of the first data is allowing us to sharpen the wavelet-based algorithm parameters used to discriminate P-waves from the continuous input signal and adapt it to specific noise conditions. A new multidisciplinary version of Mermaid using a dedicated hydrophone is designed to enlarge the band pass for acoustic signals with much higher frequency than seismic. By combining the same algorithm using wavelet transforms, and by adopting a different monitoring strategy with a dedicated processing, Mermaid is able to continuously analyzes acoustic signals to detect major seismic events, while at the same time regularly checking for weather phenomena such rain, drizzle, open sea and ice, or whale migration. This extension to multi-purpose applications makes the Mermaid very attractive for the Argo program. In fact, Mermaids using passive low cost sensors form a very light and complementary solution that can easily be integrated with an Argo float since CTD data are taken during ascent. Such multidisciplinary approach should allow seismologists to participate in international programs such as Argo and obtain the dense ocean coverage needed to image the deep structure of the Earth. We estimate that about 300 Mermaids, operated over a time span of five years, can provide a ray coverage beneath the oceans comparable to that now available beneath the continents with the Global Seismic Network (GSN). To compensate for the extra energy needed for multidisciplinary applications, Geoazur and Osean are developing a new float, called Multimermaid, that uses the same 17' glass sphere as the Ocean Bottom Seismometers constructed by Geoazur. The Multimermaid can navigate up to a depth of 3000 m and hold 2.5 times more battery power than a conventional float.

Integrated low power digital gyro control electronics

NASA Technical Reports Server (NTRS)

M'Closkey, Robert (Inventor); Grayver, Eugene (Inventor); Challoner, A. Dorian (Inventor); Hayworth, Ken J. (Inventor)

2005-01-01

Embodiments of the invention generally encompass a digital, application specific integrated circuit (ASIC) has been designed to perform excitation of a selected mode within a vibratory rate gyroscope, damping, or force-rebalance, of other modes within the sensor, and signal demodulation of the in-phase and quadrature components of the signal containing the angular rate information. The ASIC filters dedicated to each channel may be individually programmed to accommodate different rate sensor designs/technology or variations within the same class of sensors. The ASIC architecture employs a low-power design, making the ASIC, particularly suitable for use in power-sensitive applications.

Bistatic passive radar simulator with spatial filtering subsystem

NASA Astrophysics Data System (ADS)

Hossa, Robert; Szlachetko, Boguslaw; Lewandowski, Andrzej; Górski, Maksymilian

2009-06-01

The purpose of this paper is to briefly introduce the structure and features of the developed virtual passive FM radar implemented in Matlab system of numerical computations and to present many alternative ways of its performance. An idea of the proposed solution is based on analytic representation of transmitted direct signals and reflected echo signals. As a spatial filtering subsystem a beamforming network of ULA and UCA dipole configuration dedicated to bistatic radar concept is considered and computationally efficient procedures are presented in details. Finally, exemplary results of the computer simulations of the elaborated virtual simulator are provided and discussed.

Validity and reliability of an application review process using dedicated reviewers in one stage of a multi-stage admissions model.

PubMed

Zeeman, Jacqueline M; McLaughlin, Jacqueline E; Cox, Wendy C

2017-11-01

With increased emphasis placed on non-academic skills in the workplace, a need exists to identify an admissions process that evaluates these skills. This study assessed the validity and reliability of an application review process involving three dedicated application reviewers in a multi-stage admissions model. A multi-stage admissions model was utilized during the 2014-2015 admissions cycle. After advancing through the academic review, each application was independently reviewed by two dedicated application reviewers utilizing a six-construct rubric (written communication, extracurricular and community service activities, leadership experience, pharmacy career appreciation, research experience, and resiliency). Rubric scores were extrapolated to a three-tier ranking to select candidates for on-site interviews. Kappa statistics were used to assess interrater reliability. A three-facet Many-Facet Rasch Model (MFRM) determined reviewer severity, candidate suitability, and rubric construct difficulty. The kappa statistic for candidates' tier rank score (n = 388 candidates) was 0.692 with a perfect agreement frequency of 84.3%. There was substantial interrater reliability between reviewers for the tier ranking (kappa: 0.654-0.710). Highest construct agreement occurred in written communication (kappa: 0.924-0.984). A three-facet MFRM analysis explained 36.9% of variance in the ratings, with 0.06% reflecting application reviewer scoring patterns (i.e., severity or leniency), 22.8% reflecting candidate suitability, and 14.1% reflecting construct difficulty. Utilization of dedicated application reviewers and a defined tiered rubric provided a valid and reliable method to effectively evaluate candidates during the application review process. These analyses provide insight into opportunities for improving the application review process among schools and colleges of pharmacy. Copyright © 2017 Elsevier Inc. All rights reserved.

Stop feeling: inhibition of emotional interference following stop-signal trials.

PubMed

Kalanthroff, Eyal; Cohen, Noga; Henik, Avishai

2013-01-01

Although a great deal of literature has been dedicated to the mutual links between emotion and the selective attention component of executive control, there is very little data regarding the links between emotion and the inhibitory component of executive control. In the current study we employed an emotional stop-signal task in order to examine whether emotion modulates and is modulated by inhibitory control. Results replicated previous findings showing reduced inhibitory control [longer stop-signal reaction time (SSRT)] following negative, compared to neutral pictures. Most importantly, results show decreased emotional interference following stop-signal trials. These results show that the inhibitory control component of executive control can serve to decrease emotional effects. We suggest that inhibitory control and emotion have a two-way connection in which emotion disrupts inhibitory control and activation of inhibitory control disrupts emotion.

Optical communications for transport aircraft

NASA Technical Reports Server (NTRS)

Stengel, Robert

1994-01-01

Optical communications for transport aircraft are discussed. The problem involves: increasing demand for radio-frequency bands from an enlarging pool of users (aircraft, ground and sea vehicles, fleet operators, traffic control centers, and commercial radio and television); desirability of providing high-bandwidth dedicated communications to and from every aircraft in the National Airspace System; need to support communications, navigation, and surveillance for a growing number of aircraft; and improved meteorological observations by use of probe aircraft. The solution involves: optical signal transmission support very high data rates; optical transmission of signals between aircraft, orbiting satellites, and ground stations, where unobstructed line-of-sight is available; conventional radio transmissions of signals between aircraft and ground stations, where optical line-of-sight is unavailable; and radio priority given to aircraft in weather.

Reducing radiation dose to the female breast during conventional and dedicated breast computed tomography

NASA Astrophysics Data System (ADS)

Rupcich, Franco John

The purpose of this study was to quantify the effectiveness of techniques intended to reduce dose to the breast during CT coronary angiography (CTCA) scans with respect to task-based image quality, and to evaluate the effectiveness of optimal energy weighting in improving contrast-to-noise ratio (CNR), and thus the potential for reducing breast dose, during energy-resolved dedicated breast CT. A database quantifying organ dose for several radiosensitive organs irradiated during CTCA, including the breast, was generated using Monte Carlo simulations. This database facilitates estimation of organ-specific dose deposited during CTCA protocols using arbitrary x-ray spectra or tube-current modulation schemes without the need to run Monte Carlo simulations. The database was used to estimate breast dose for simulated CT images acquired for a reference protocol and five protocols intended to reduce breast dose. For each protocol, the performance of two tasks (detection of signals with unknown locations) was compared over a range of breast dose levels using a task-based, signal-detectability metric: the estimator of the area under the exponential free-response relative operating characteristic curve, AFE. For large-diameter/medium-contrast signals, when maintaining equivalent AFE, the 80 kV partial, 80 kV, 120 kV partial, and 120 kV tube-current modulated protocols reduced breast dose by 85%, 81%, 18%, and 6%, respectively, while the shielded protocol increased breast dose by 68%. Results for the small-diameter/high-contrast signal followed similar trends, but with smaller magnitude of the percent changes in dose. The 80 kV protocols demonstrated the greatest reduction to breast dose, however, the subsequent increase in noise may be clinically unacceptable. Tube output for these protocols can be adjusted to achieve more desirable noise levels with lesser dose reduction. The improvement in CNR of optimally projection-based and image-based weighted images relative to photon-counting was investigated for six different energy bin combinations using a bench-top energy-resolving CT system with a cadmium zinc telluride (CZT) detector. The non-ideal spectral response reduced the CNR for the projection-based weighted images, while image-based weighting improved CNR for five out of the six investigated bin combinations, despite this non-ideal response, indicating potential for image-based weighting to reduce breast dose during dedicated breast CT.

Introduction to Flight Test Engineering (Introduction aux techniques des essais en vol)

DTIC Science & Technology

2005-07-01

or aircraft parameters • Calculations in the frequency domain ( Fast Fourier Transform) • Data analysis with dedicated software for: • Signal...density Fast Fourier Transform Transfer function analysis Frequency response analysis Etc. PRESENTATION Color/black & white Display screen...envelope by operating the airplane at increasing ranges - representing increasing risk - of engine operation, airspeeds both fast and slow, altitude

FPGA Based High Speed Data Acquisition System for Electrical Impedance Tomography

PubMed Central

Khan, S; Borsic, A; Manwaring, Preston; Hartov, Alexander; Halter, Ryan

2014-01-01

Electrical Impedance Tomography (EIT) systems are used to image tissue bio-impedance. EIT provides a number of features making it attractive for use as a medical imaging device including the ability to image fast physiological processes (>60 Hz), to meet a range of clinical imaging needs through varying electrode geometries and configurations, to impart only non-ionizing radiation to a patient, and to map the significant electrical property contrasts present between numerous benign and pathological tissues. To leverage these potential advantages for medical imaging, we developed a modular 32 channel data acquisition (DAQ) system using National Instruments’ PXI chassis, along with FPGA, ADC, Signal Generator and Timing and Synchronization modules. To achieve high frame rates, signal demodulation and spectral characteristics of higher order harmonics were computed using dedicated FFT-hardware built into the FPGA module. By offloading the computing onto FPGA, we were able to achieve a reduction in throughput required between the FPGA and PC by a factor of 32:1. A custom designed analog front end (AFE) was used to interface electrodes with our system. Our system is wideband, and capable of acquiring data for input signal frequencies ranging from 100 Hz to 12 MHz. The modular design of both the hardware and software will allow this system to be flexibly configured for the particular clinical application. PMID:24729790

Dedicated computer system AOTK for image processing and analysis of horse navicular bone

NASA Astrophysics Data System (ADS)

Zaborowicz, M.; Fojud, A.; Koszela, K.; Mueller, W.; Górna, K.; Okoń, P.; Piekarska-Boniecka, H.

2017-07-01

The aim of the research was made the dedicated application AOTK (pol. Analiza Obrazu Trzeszczki Kopytowej) for image processing and analysis of horse navicular bone. The application was produced by using specialized software like Visual Studio 2013 and the .NET platform. To implement algorithms of image processing and analysis were used libraries of Aforge.NET. Implemented algorithms enabling accurate extraction of the characteristics of navicular bones and saving data to external files. Implemented in AOTK modules allowing the calculations of distance selected by user, preliminary assessment of conservation of structure of the examined objects. The application interface is designed in a way that ensures user the best possible view of the analyzed images.

Life sciences flight experiments program mission science requirements document. The first life sciences dedicated Spacelab mission, part 1

NASA Technical Reports Server (NTRS)

Rummel, J. A.

1982-01-01

The Mission Science Requirements Document (MSRD) for the First Dedicated Life Sciences Mission (LS-1) represents the culmination of thousands of hours of experiment selection, and science requirement definition activities. NASA life sciences has never before attempted to integrate, both scientifically and operationally, a single mission dedicated to life sciences research, and the complexity of the planning required for such an endeavor should be apparent. This set of requirements completes the first phase of a continual process which will attempt to optimize (within available programmatic and mission resources) the science accomplished on this mission.

A Type I Signal Peptidase Is Required for Pilus Assembly in the Gram-Positive, Biofilm-Forming Bacterium Actinomyces oris

PubMed Central

Siegel, Sara D.

2016-01-01

ABSTRACT The Gram-positive bacterium Actinomyces oris, a key colonizer in the development of oral biofilms, contains 18 LPXTG motif-containing proteins, including fimbrillins that constitute two fimbrial types critical for adherence, biofilm formation, and polymicrobial interactions. Export of these protein precursors, which harbor a signal peptide, is thought to be mediated by the Sec machine and require cleavage of the signal peptide by type I signal peptidases (SPases). Like many Gram-positive bacteria, A. oris expresses two SPases, named LepB1 and LepB2. The latter has been linked to suppression of lethal “glyco-stress,” caused by membrane accumulation of the LPXTG motif-containing glycoprotein GspA when the housekeeping sortase srtA is genetically disrupted. Consistent with this finding, we show here that a mutant lacking lepB2 and srtA was unable to produce high levels of glycosylated GspA and hence was viable. However, deletion of neither lepB1 nor lepB2 abrogated the signal peptide cleavage and glycosylation of GspA, indicating redundancy of SPases for GspA. In contrast, the lepB2 deletion mutant failed to assemble the wild-type levels of type 1 and 2 fimbriae, which are built by the shaft fimbrillins FimP and FimA, respectively; this phenotype was attributed to aberrant cleavage of the fimbrillin signal peptides. Furthermore, the lepB2 mutants, including the catalytically inactive S101A and K169A variants, exhibited significant defects in polymicrobial interactions and biofilm formation. Conversely, lepB1 was dispensable for the aforementioned processes. These results support the idea that LepB2 is specifically utilized for processing of fimbrial proteins, thus providing an experimental model with which to study the basis of type I SPase specificity. IMPORTANCE Sec-mediated translocation of bacterial protein precursors across the cytoplasmic membrane involves cleavage of their signal peptide by a signal peptidase (SPase). Like many Gram-positive bacteria, A. oris expresses two SPases, LepB1 and LepB2. The latter is a genetic suppressor of lethal “glyco-stress” caused by membrane accumulation of glycosylated GspA when the housekeeping sortase srtA is genetically disrupted. We show here that LepB1 and LepB2 are capable of processing GspA, whereas only LepB2 is required for cleavage of fimbrial signal peptides. This is the first example of a type I SPase dedicated to LPXTG motif-containing fimbrial proteins. Thus, A. oris provides an experimental model with which to investigate the specificity mechanism of type I SPases. PMID:27215787

A Type I Signal Peptidase Is Required for Pilus Assembly in the Gram-Positive, Biofilm-Forming Bacterium Actinomyces oris.

PubMed

Siegel, Sara D; Wu, Chenggang; Ton-That, Hung

2016-08-01

The Gram-positive bacterium Actinomyces oris, a key colonizer in the development of oral biofilms, contains 18 LPXTG motif-containing proteins, including fimbrillins that constitute two fimbrial types critical for adherence, biofilm formation, and polymicrobial interactions. Export of these protein precursors, which harbor a signal peptide, is thought to be mediated by the Sec machine and require cleavage of the signal peptide by type I signal peptidases (SPases). Like many Gram-positive bacteria, A. oris expresses two SPases, named LepB1 and LepB2. The latter has been linked to suppression of lethal "glyco-stress," caused by membrane accumulation of the LPXTG motif-containing glycoprotein GspA when the housekeeping sortase srtA is genetically disrupted. Consistent with this finding, we show here that a mutant lacking lepB2 and srtA was unable to produce high levels of glycosylated GspA and hence was viable. However, deletion of neither lepB1 nor lepB2 abrogated the signal peptide cleavage and glycosylation of GspA, indicating redundancy of SPases for GspA. In contrast, the lepB2 deletion mutant failed to assemble the wild-type levels of type 1 and 2 fimbriae, which are built by the shaft fimbrillins FimP and FimA, respectively; this phenotype was attributed to aberrant cleavage of the fimbrillin signal peptides. Furthermore, the lepB2 mutants, including the catalytically inactive S101A and K169A variants, exhibited significant defects in polymicrobial interactions and biofilm formation. Conversely, lepB1 was dispensable for the aforementioned processes. These results support the idea that LepB2 is specifically utilized for processing of fimbrial proteins, thus providing an experimental model with which to study the basis of type I SPase specificity. Sec-mediated translocation of bacterial protein precursors across the cytoplasmic membrane involves cleavage of their signal peptide by a signal peptidase (SPase). Like many Gram-positive bacteria, A. oris expresses two SPases, LepB1 and LepB2. The latter is a genetic suppressor of lethal "glyco-stress" caused by membrane accumulation of glycosylated GspA when the housekeeping sortase srtA is genetically disrupted. We show here that LepB1 and LepB2 are capable of processing GspA, whereas only LepB2 is required for cleavage of fimbrial signal peptides. This is the first example of a type I SPase dedicated to LPXTG motif-containing fimbrial proteins. Thus, A. oris provides an experimental model with which to investigate the specificity mechanism of type I SPases. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Interventional MR: vascular applications.

PubMed

Smits, H F; Bos, C; van der Weide, R; Bakker, C J

1999-01-01

Three strategies for visualisation of MR-dedicated guidewires and catheters have been proposed, namely active tracking, the technique of locally induced field inhomogeneity and passive susceptibility-based tracking. In this article the pros and cons of these techniques are discussed, including the development of MR-dedicated guidewires and catheters, scan techniques, post-processing tools, and display facilities for MR tracking. Finally, some of the results obtained with MR tracking are discussed.

Simulating aerial gravitropism and posture control in plants: what has been done, what is missing

NASA Astrophysics Data System (ADS)

Coutand, Catherine; Pot, Guillaume; Bastien, R.; Badel, Eric; Moulia, Bruno

The gravitropic response requires a process of perception of the signal and a motor process to actuate the movements. Different models have been developed, some focuses on the perception process and some focuses on the motor process. The kinematics of the gravitropic response will be first detailed to set the phenomenology of gravi- and auto-tropism. A model of perception (AC model) will be first presented to demonstrate that sensing inclination is not sufficient to control the gravitropic movement, and that proprioception is also involved. Then, “motor models” will be reviewed. In herbaceous plants, differential growth is the main motor. Modelling tropic movements with simulating elongation raises some difficulties that will be explained. In woody structures the main motor process is the differentiation of reaction wood via cambial growth. We will first present the simplest biomechanical model developed to simulate gravitropism and its limits will be pointed out. Then a more sophisticated model (TWIG) will be presented with a special focus on the importance of wood viscoelasticity and the wood maturation process and its regulation by a mechanosensing process. The presentation will end by a balance sheet of what is done and what is missing for a complete modelling of gravitropism and will present first results of a running project dedicating to get the data required to include phototropism in the actual models.

Rapid and Robust Cross-Correlation-Based Seismic Phase Identification Using an Approximate Nearest Neighbor Method

NASA Astrophysics Data System (ADS)

Tibi, R.; Young, C. J.; Gonzales, A.; Ballard, S.; Encarnacao, A. V.

2016-12-01

The matched filtering technique involving the cross-correlation of a waveform of interest with archived signals from a template library has proven to be a powerful tool for detecting events in regions with repeating seismicity. However, waveform correlation is computationally expensive, and therefore impractical for large template sets unless dedicated distributed computing hardware and software are used. In this study, we introduce an Approximate Nearest Neighbor (ANN) approach that enables the use of very large template libraries for waveform correlation without requiring a complex distributed computing system. Our method begins with a projection into a reduced dimensionality space based on correlation with a randomized subset of the full template archive. Searching for a specified number of nearest neighbors is accomplished by using randomized K-dimensional trees. We used the approach to search for matches to each of 2700 analyst-reviewed signal detections reported for May 2010 for the IMS station MKAR. The template library in this case consists of a dataset of more than 200,000 analyst-reviewed signal detections for the same station from 2002-2014 (excluding May 2010). Of these signal detections, 60% are teleseismic first P, and 15% regional phases (Pn, Pg, Sn, and Lg). The analyses performed on a standard desktop computer shows that the proposed approach performs the search of the large template libraries about 20 times faster than the standard full linear search, while achieving recall rates greater than 80%, with the recall rate increasing for higher correlation values. To decide whether to confirm a match, we use a hybrid method involving a cluster approach for queries with two or more matches, and correlation score for single matches. Of the signal detections that passed our confirmation process, 52% were teleseismic first P, and 30% were regional phases.

Quantum memories: emerging applications and recent advances

NASA Astrophysics Data System (ADS)

Heshami, Khabat; England, Duncan G.; Humphreys, Peter C.; Bustard, Philip J.; Acosta, Victor M.; Nunn, Joshua; Sussman, Benjamin J.

2016-11-01

Quantum light-matter interfaces are at the heart of photonic quantum technologies. Quantum memories for photons, where non-classical states of photons are mapped onto stationary matter states and preserved for subsequent retrieval, are technical realizations enabled by exquisite control over interactions between light and matter. The ability of quantum memories to synchronize probabilistic events makes them a key component in quantum repeaters and quantum computation based on linear optics. This critical feature has motivated many groups to dedicate theoretical and experimental research to develop quantum memory devices. In recent years, exciting new applications, and more advanced developments of quantum memories, have proliferated. In this review, we outline some of the emerging applications of quantum memories in optical signal processing, quantum computation and non-linear optics. We review recent experimental and theoretical developments, and their impacts on more advanced photonic quantum technologies based on quantum memories.

An extrinsic fiber Fabry-Perot interferometer for dynamic displacement measurement

NASA Astrophysics Data System (ADS)

Pullteap, S.; Seat, H. C.

2015-03-01

A versatile fiber interferometer was proposed for high precision measurement. The sensor exploited a double-cavity within the unique sensing arm of an extrinsic-type fiber Fabry-Perot interferometer to produce the quadrature phase-shifted interference fringes. Interference signal processing was carried out using a modified zero-crossing (fringe) counting technique to demodulate two sets of fringes. The fiber interferometer has been successfully employed for dynamic displacement measurement under different displacement profiles over a range of 0.7 μm to 140 μm. A dedicated computer incorporating the demodulation algorithm was next used to interpret these detected data as well as plot the displacement information with a resolution of λ/64. A commercial displacement sensor was employed for comparison purposes with the experimental data obtained from the fiber interferometer as well as to gauge its performance, resulting in the maximum error of 2.8% over the entire displacement range studied.

A Test Apparatus for the MAJORANA DEMONSTRATOR Front-end Electronics

NASA Astrophysics Data System (ADS)

Singh, Harjit; Loach, James; Poon, Alan

2012-10-01

One of the most important experimental programs in neutrino physics is the search for neutrinoless double-beta decay. The MAJORANA collaboration is searching for this rare nuclear process in the Ge-76 isotope using HPGe detectors. Each detector is instrumented with high-performance electronics to read out and amplify the signals. The part of the electronics close to the detectors, consisting of a novel front-end circuit, cables and connectors, is made of radio-pure materials and is exceedingly delicate. In this work a dedicated test apparatus was created to benchmark the performance of the electronics before installation in the experiment. The apparatus was designed for cleanroom use, with fixtures to hold the components without contaminating them, and included the electronics necessary for power and readout. In addition to testing, the station will find longer term use in development of future versions of the electronics.

Quantum memories: emerging applications and recent advances.

PubMed

Heshami, Khabat; England, Duncan G; Humphreys, Peter C; Bustard, Philip J; Acosta, Victor M; Nunn, Joshua; Sussman, Benjamin J

2016-11-12

Quantum light-matter interfaces are at the heart of photonic quantum technologies. Quantum memories for photons, where non-classical states of photons are mapped onto stationary matter states and preserved for subsequent retrieval, are technical realizations enabled by exquisite control over interactions between light and matter. The ability of quantum memories to synchronize probabilistic events makes them a key component in quantum repeaters and quantum computation based on linear optics. This critical feature has motivated many groups to dedicate theoretical and experimental research to develop quantum memory devices. In recent years, exciting new applications, and more advanced developments of quantum memories, have proliferated. In this review, we outline some of the emerging applications of quantum memories in optical signal processing, quantum computation and non-linear optics. We review recent experimental and theoretical developments, and their impacts on more advanced photonic quantum technologies based on quantum memories.

Osteoimmunology - Unleashing the concepts

PubMed Central

Murthy, M. Bhanu

2011-01-01

Osteoimmunology is an emerging field of research dedicated to the relationship between the immune processes and the bone metabolism of various inflammatory bone diseases. The regulatory mechanisms governing the osteoclast and osteoblast are critical for understanding the health and disease of the skeletal system. These interactions are either by cell to cell contact or by the secretion of immune regulatory mediators like cytokines and chemokines by immune cells that are governed by the RANKL (TRANCE)-RANK- OPG axis. TRANCE-RANK signaling has served as a cornerstone of osteoimmunology research. There is increased recognition of the importance of the inflammatory and immune responses in the pathogenesis of periodontal disease. Thus, this field has provided a framework for studying the mechanisms underlying periodontal destruction. As bone homeostasis is mainly regulated by both the immune and endocrine systems, there emerged osteoimmunoendocrinology where adipokines take the lead. This review focuses on the underlying concepts of osteoimmunology, its relation to Periodontics. PMID:22028503

Search for Large Presolar Silicate Grains in the QUE 99177 CR Chondrite

NASA Technical Reports Server (NTRS)

Nguyen, A. N.; Messenger, S.

2012-01-01

Silicates are among the most abundant pre-solar grain type, and their diverse chemical and isotopic compos-tions preserve detailed constraints on their stellar origins, condensation conditions, and nucleosynthetic and interstellar processes. Yet, owing to their small sizes, relatively few grains have been measured for isotopic compositions besides O and Si, and their mineralogy is poorly characterized. The average grain size (approx 270 nm) limits the number of analyses that can be conducted on a given grain, and their identification among solar system silicates introduces contaminating signal. These difficulties can be overcome by identifying large presolar silicate grains. However, such grains are very rare and only two approx 1 micron grains have been discovered. We are conducting a dedicated search for large presolar silicates in size-separated QUE 99177 matrix material. This primitive meteorite has among the highest abundance of presolar silicates

Quantum memories: emerging applications and recent advances

PubMed Central

Heshami, Khabat; England, Duncan G.; Humphreys, Peter C.; Bustard, Philip J.; Acosta, Victor M.; Nunn, Joshua; Sussman, Benjamin J.

2016-01-01

Quantum light–matter interfaces are at the heart of photonic quantum technologies. Quantum memories for photons, where non-classical states of photons are mapped onto stationary matter states and preserved for subsequent retrieval, are technical realizations enabled by exquisite control over interactions between light and matter. The ability of quantum memories to synchronize probabilistic events makes them a key component in quantum repeaters and quantum computation based on linear optics. This critical feature has motivated many groups to dedicate theoretical and experimental research to develop quantum memory devices. In recent years, exciting new applications, and more advanced developments of quantum memories, have proliferated. In this review, we outline some of the emerging applications of quantum memories in optical signal processing, quantum computation and non-linear optics. We review recent experimental and theoretical developments, and their impacts on more advanced photonic quantum technologies based on quantum memories. PMID:27695198

Estimating Noise in the Hydrogen Epoch of Reionization Array

NASA Astrophysics Data System (ADS)

Englund Mathieu, Philip; HERA Team

2017-01-01

The Hydrogen Epoch of Reionization Array (HERA) is a radio telescope dedicated to observing large scale structure during and prior to the epoch of reionization. Once completed, HERA will have unprecedented sensitivity to the 21-cm signal from hydrogen reionization. This poster will present time- and frequency-subtraction methods and results from a preliminary analysis of the noise characteristics of the nineteen-element pathfinder array.

The Dynamic Radio Sky: An Opportunity for Discovery

DTIC Science & Technology

2010-01-01

brown dwarfs, flare stars extrasolar planets signals from ET civilizations pulsar giant pulses, inter- mittant pulsars , magnetar flares, X-ray binaries...giant pulses from the Crab pulsar , a small number of dedicated radio transient surveys, and the serendipitous discovery of transient radio sources...transients. 3.1 Case Study: Rotating Radio Transients—A New Population of Neutron Stars The first pulsars were discovered through visual inspection of

A no-tune no-match wideband probe for nuclear quadrupole resonance spectroscopy in the VHF range

NASA Astrophysics Data System (ADS)

Scharfetter, Hermann; Petrovic, Andreas; Eggenhofer, Heidi; Stollberger, Rudolf

2014-12-01

Nuclear quadrupole resonance (NQR) spectroscopy is a method for the characterization of chemical compounds containing so-called quadrupolar nuclei. Similar to nuclear magnetic resonance (NMR), the sample under investigation is irradiated with strong radiofrequency (RF) pulses, which stimulate the emission of weak RF signals from the quadrupolar nuclei. The signals are then amplified and Fourier transformed so as to obtain a spectrum. In principle, narrowband NQR spectra can be measured with NMR spectrometers. However, pure NQR signals require the absence of a static magnetic field and several special applications require the characterization of a substance over a large bandwidth, e.g. 50-100% of the central frequency, which is hardly possible with standard NMR equipment. Dedicated zero-field NQR equipment is not widespread and current concepts employ resonating probes which are tuned and matched over a wide range by using mechanical capacitors driven by stepper motors. While providing the highest signal to noise ratio (SNR) such probes are slow in operation and can only be operated from dedicated NMR consoles. We developed a low-cost NQR wideband probe without tuning and matching for applications in the very high frequency (VHF) range below 300 MHz. The probe coil was realized as part of a reactive network which approximates an exponential transmission line. The input reflection coefficient of the two developed prototype probe coils is ≤ 20 dB between 90-145 MHz and 74.5-99.5 MHz, respectively. Two wideband NQR spectra of published test substances were acquired with an SNR of better than 20 dB after sufficient averaging. The measured signals and the SNR correspond very well to the theoretically expected values and demonstrate the feasibility of the method. Because there is no need for tuning and matching, our probes can be operated easily from any available NMR console.

Studying Cosmic Evolution with 21 cm Intensity Mapping

NASA Astrophysics Data System (ADS)

Anderson, Christopher

This thesis describes early work in the developing field of 21-cm intensity mapping. The 21-cm line is a radio transition due to the hyperfine splitting of the ground state of neutral hydrogen (HI). Intensity mapping utilizes the aggregate redshifted 21-cm emission to map the three-dimensional distribution of HI on large scales. In principle, the 21-cm line can be utilized to map most of the volume of the observable Universe. But the signal is small, and dedicated instruments will be required to reach a high signal-to-noise ratio. Large spectrally smooth astrophysical foregrounds, which dwarf the 21-cm signal, present a significant challenge to the data analysis. I derive the fundamental physics of the 21-cm line and the size of the expected cosmological signal. I also provide an overview of the desired characteristics of a dedicated 21-cm instrument, and I list some instruments that are coming on-line in the next few years. I then describe the data analysis techniques and results for 21-cm intensity maps that were made with two existing radio telescopes, the Green Bank telescope (GBT) and the Parkes telescope. Both observations have detected the 21-cm HI signal by cross-correlating the 21-cm intensity maps with overlapping optical galaxy surveys. The GBT maps have been used to constrain the neutral hydrogen density at a mean redshift (z) of 0.8. The Parkes maps, at a mean redshift of 0.08, probe smaller scales. The Parkes 21-cm intensity maps reveal a lack of small-scale clustering when they are cross-correlated with 2dF optical galaxy maps. This lack of small-scale clustering is partially due to a scale-dependent and galaxy-color-dependent HI-galaxy cross- correlation coefficient. Lastly, I provide an overview of planned future analyses with the Parkes maps, with a proposed multi-beam receiver for the Green Bank telescope, and with simulations of systematic effects on foregrounds.

Analysing exoplanetary data using unsupervised machine-learning

NASA Astrophysics Data System (ADS)

Waldmann, I. P.

2012-04-01

The field of transiting extrasolar planets and especially the study of their atmospheres is one of the youngest and most dynamic subjects in current astrophysics. Permanently at the edge of technical feasibility, we are successfully discovering and characterising smaller and smaller planets. To study exoplanetary atmospheres, we typically require a 10-4 to 10-5 level of accuracy in flux. Achieving such a precision has become the central challenge to exoplanetary research and is often impeded by systematic (nongaussian) noise from either the instrument, stellar activity or both. Dedicated missions, such as Kepler, feature an a priori instrument calibration plan to the required accuracy but nonetheless remain limited by stellar systematics. More generic instruments often lack a sufficiently defined instrument response function, making it very hard to calibrate. In these cases, it becomes interesting to know how well we can calibrate the data without any additional or prior knowledge of the instrument or star. In this conference, we present a non-parametric machine-learning algorithm, based on the concept of independent component analysis, to de-convolve the systematic noise and all non-Gaussian signals from the desired astrophysical signal. Such a 'blind' signal de-mixing is commonly known as the 'Cocktail Party problem' in signal-processing. We showcase the importance and broad applicability of unsupervised machine learning in exoplanetary data analysis by discussing: 1) the removal of instrument systematics in a re-analysis of an HD189733b transmission spectrum obtained with Hubble/NICMOS; 2) the removal of time-correlated stellar noise in individual lightcurves observed by the Kepler mission.

Performance of a Micro-Strip Gas Chamber for event wise, high rate thermal neutron detection with accurate 2D position determination

NASA Astrophysics Data System (ADS)

Mindur, B.; Alimov, S.; Fiutowski, T.; Schulz, C.; Wilpert, T.

2014-12-01

A two-dimensional (2D) position sensitive detector for neutron scattering applications based on low-pressure gas amplification and micro-strip technology was built and tested with an innovative readout electronics and data acquisition system. This detector contains a thin solid neutron converter and was developed for time- and thus wavelength-resolved neutron detection in single-event counting mode, which improves the image contrast in comparison with integrating detectors. The prototype detector of a Micro-Strip Gas Chamber (MSGC) was built with a solid natGd/CsI thermal neutron converter for spatial resolutions of about 100 μm and counting rates up to 107 neutrons/s. For attaining very high spatial resolutions and counting rates via micro-strip readout with centre-of-gravity evaluation of the signal amplitude distributions, a fast, channel-wise, self-triggering ASIC was developed. The front-end chips (MSGCROCs), which are very first signal processing components, are read out into powerful ADC-FPGA boards for on-line data processing and thereafter via Gigabit Ethernet link into the data receiving PC. The workstation PC is controlled by a modular, high performance dedicated software suite. Such a fast and accurate system is crucial for efficient radiography/tomography, diffraction or imaging applications based on high flux thermal neutron beam. In this paper a brief description of the detector concept with its operation principles, readout electronics requirements and design together with the signals processing stages performed in hardware and software are presented. In more detail the neutron test beam conditions and measurement results are reported. The focus of this paper is on the system integration, two dimensional spatial resolution, the time resolution of the readout system and the imaging capabilities of the overall setup. The detection efficiency of the detector prototype is estimated as well.

Low b-value diffusion-weighted cardiac magnetic resonance imaging: initial results in humans using an optimal time-window imaging approach.

PubMed

Rapacchi, Stanislas; Wen, Han; Viallon, Magalie; Grenier, Denis; Kellman, Peter; Croisille, Pierre; Pai, Vinay M

2011-12-01

Diffusion-weighted imaging (DWI) using low b-values permits imaging of intravoxel incoherent motion in tissues. However, low b-value DWI of the human heart has been considered too challenging because of additional signal loss due to physiological motion, which reduces both signal intensity and the signal-to-noise ratio (SNR). We address these signal loss concerns by analyzing cardiac motion during a heartbeat to determine the time-window during which cardiac bulk motion is minimal. Using this information to optimize the acquisition of DWI data and combining it with a dedicated image processing approach has enabled us to develop a novel low b-value diffusion-weighted cardiac magnetic resonance imaging approach, which significantly reduces intravoxel incoherent motion measurement bias introduced by motion. Simulations from displacement encoded motion data sets permitted the delineation of an optimal time-window with minimal cardiac motion. A number of single-shot repetitions of low b-value DWI cardiac magnetic resonance imaging data were acquired during this time-window under free-breathing conditions with bulk physiological motion corrected for by using nonrigid registration. Principal component analysis (PCA) was performed on the registered images to improve the SNR, and temporal maximum intensity projection (TMIP) was applied to recover signal intensity from time-fluctuant motion-induced signal loss. This PCATMIP method was validated with experimental data, and its benefits were evaluated in volunteers before being applied to patients. Optimal time-window cardiac DWI in combination with PCATMIP postprocessing yielded significant benefits for signal recovery, contrast-to-noise ratio, and SNR in the presence of bulk motion for both numerical simulations and human volunteer studies. Analysis of mean apparent diffusion coefficient (ADC) maps showed homogeneous values among volunteers and good reproducibility between free-breathing and breath-hold acquisitions. The PCATMIP DWI approach also indicated its potential utility by detecting ADC variations in acute myocardial infarction patients. Studying cardiac motion may provide an appropriate strategy for minimizing the impact of bulk motion on cardiac DWI. Applying PCATMIP image processing improves low b-value DWI and enables reliable analysis of ADC in the myocardium. The use of a limited number of repetitions in a free-breathing mode also enables easier application in clinical conditions.

A facility to study the particles released by ion sputtering process

NASA Astrophysics Data System (ADS)

de Angelis, E.; di Lellis, A. M.; Vannaroni, G.; Orsini, S.; Mangano, V.; Milillo, A.; Massetti, S.; Mura, A.; Vertolli, N.

2007-08-01

Research on the planetary surface erosion and planetary evolution could be enriched with the detection of the escaping material, in terms of energy and direction, caused by ions sputtering. A complete study of emitted neutral distribution from which infers the processes occurring on the impacted surface requires dedicated instrumentation, tailored on the peculiarity on the low energy profile of the sputtered signal. We propose a comprehensive facility at INAF/IFSI in Rome intended to provide the opportunity to investigate the interaction of selectable ion beam with planetary analogues through the detection of sputtered neutral atoms. The laboratory is equipped with a high volume UHV chamber, ion selectable sources in the range 0 to 10 keV, a set of 3D sample/sensor orientation motion actuation motors down to 1/100 deg resolution. The laboratory will support a set of neutral sensor heads sets derived from the Emitted for Low Energetic Neutral Atoms (ELENA) instrument under development for the ESA BepiColombo Mercury mission able to detect neutral atoms (few eV-up to 5 keV).

IEEE International Symposium on Biomedical Imaging.

PubMed

2017-01-01

The IEEE International Symposium on Biomedical Imaging (ISBI) is a scientific conference dedicated to mathematical, algorithmic, and computational aspects of biological and biomedical imaging, across all scales of observation. It fosters knowledge transfer among different imaging communities and contributes to an integrative approach to biomedical imaging. ISBI is a joint initiative from the IEEE Signal Processing Society (SPS) and the IEEE Engineering in Medicine and Biology Society (EMBS). The 2018 meeting will include tutorials, and a scientific program composed of plenary talks, invited special sessions, challenges, as well as oral and poster presentations of peer-reviewed papers. High-quality papers are requested containing original contributions to the topics of interest including image formation and reconstruction, computational and statistical image processing and analysis, dynamic imaging, visualization, image quality assessment, and physical, biological, and statistical modeling. Accepted 4-page regular papers will be published in the symposium proceedings published by IEEE and included in IEEE Xplore. To encourage attendance by a broader audience of imaging scientists and offer additional presentation opportunities, ISBI 2018 will continue to have a second track featuring posters selected from 1-page abstract submissions without subsequent archival publication.

Can the fluctuations of motion be used to estimate the performance of kayak paddlers?

NASA Astrophysics Data System (ADS)

Vadai, Gergely; Gingl, Zoltán

2016-05-01

Today many compact and efficient on-water data acquisition units help modern coaching by measuring and analyzing various inertial signals during kayaking. One of the most challenging problems is how these signals can be used to estimate performance and to develop the technique. Recently we have introduced indicators based on the fluctuations of the inertial signals as promising additions to the existing parameters. In this work we report on our more detailed analysis, compare new indicators, and discuss the possible advantages of the applied methods. Our primary aim is to draw attention to several exciting and inspiring open problems and to initiate further research even in several related multidisciplinary fields. More detailed information can be found on the dedicated webpage, www.noise.inf.u-szeged.hu/kayak.

Methodology for creating dedicated machine and algorithm on sunflower counting

NASA Astrophysics Data System (ADS)

Muracciole, Vincent; Plainchault, Patrick; Mannino, Maria-Rosaria; Bertrand, Dominique; Vigouroux, Bertrand

2007-09-01

In order to sell grain lots in European countries, seed industries need a government certification. This certification requests purity testing, seed counting in order to quantify specified seed species and other impurities in lots, and germination testing. These analyses are carried out within the framework of international trade according to the methods of the International Seed Testing Association. Presently these different analyses are still achieved manually by skilled operators. Previous works have already shown that seeds can be characterized by around 110 visual features (morphology, colour, texture), and thus have presented several identification algorithms. Until now, most of the works in this domain are computer based. The approach presented in this article is based on the design of dedicated electronic vision machine aimed to identify and sort seeds. This machine is composed of a FPGA (Field Programmable Gate Array), a DSP (Digital Signal Processor) and a PC bearing the GUI (Human Machine Interface) of the system. Its operation relies on the stroboscopic image acquisition of a seed falling in front of a camera. A first machine was designed according to this approach, in order to simulate all the vision chain (image acquisition, feature extraction, identification) under the Matlab environment. In order to perform this task into dedicated hardware, all these algorithms were developed without the use of the Matlab toolbox. The objective of this article is to present a design methodology for a special purpose identification algorithm based on distance between groups into dedicated hardware machine for seed counting.

Note: Inter-satellite laser range-rate measurement by using digital phase locked loop.

PubMed

Liang, Yu-Rong; Duan, Hui-Zong; Xiao, Xin-Long; Wei, Bing-Bing; Yeh, Hsien-Chi

2015-01-01

This note presents an improved high-resolution frequency measurement system dedicated for the inter-satellite range-rate monitoring that could be used in the future's gravity recovery mission. We set up a simplified common signal test instead of the three frequencies test. The experimental results show that the dominant noises are the sampling time jitter and the thermal drift of electronic components, which can be reduced by using the pilot-tone correction and passive thermal control. The improved noise level is about 10(-8) Hz/Hz(1/2)@0.01Hz, limited by the signal-to-noise ratio of the sampling circuit.

Note: Inter-satellite laser range-rate measurement by using digital phase locked loop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liang, Yu-Rong; Department of Electronics and Information Engineering, Huazhong University of Science and Technology, 1037 Luo Yu Road, Wuhan 430074; Duan, Hui-Zong

2015-01-15

This note presents an improved high-resolution frequency measurement system dedicated for the inter-satellite range-rate monitoring that could be used in the future’s gravity recovery mission. We set up a simplified common signal test instead of the three frequencies test. The experimental results show that the dominant noises are the sampling time jitter and the thermal drift of electronic components, which can be reduced by using the pilot-tone correction and passive thermal control. The improved noise level is about 10{sup −8} Hz/Hz{sup 1/2}@0.01Hz, limited by the signal-to-noise ratio of the sampling circuit.

Note: Inter-satellite laser range-rate measurement by using digital phase locked loop

NASA Astrophysics Data System (ADS)

Liang, Yu-Rong; Duan, Hui-Zong; Xiao, Xin-Long; Wei, Bing-Bing; Yeh, Hsien-Chi

2015-01-01

This note presents an improved high-resolution frequency measurement system dedicated for the inter-satellite range-rate monitoring that could be used in the future's gravity recovery mission. We set up a simplified common signal test instead of the three frequencies test. The experimental results show that the dominant noises are the sampling time jitter and the thermal drift of electronic components, which can be reduced by using the pilot-tone correction and passive thermal control. The improved noise level is about 10-8 Hz/Hz1/2@0.01Hz, limited by the signal-to-noise ratio of the sampling circuit.

Real time spectrometer for thermal neutrons from radiotherapic accelerators

NASA Astrophysics Data System (ADS)

Mozzanica, A.; Bartesaghi, G.; Bolognini, D.; Conti, V.; Mascagna, V.; Prest, M.; Scazzi, S.; Cappelletti, P.; Frigerio, M.; Gelosa, S.; Monti, A.; Ostinelli, A.; Bevilacqua, R.; Giannini, G.; Totaro, P.; Vallazza, E.

2007-10-01

Radiotherapy accelerators can produce high energy photon beams for deep tumour treatments. Photons with energies greater than 8 MeV produce neutrons via photoproduction. The PHONES (PHOto NEutron Source) project is developing a neutron moderator to use the photoproduced neutrons for BNCT (Boron Neutron Capture Therapy) in hospital environments. In this framework we are developing a real time spectrometer for thermal neutrons exploiting the bunch structure of the beam. Since the beam is produced by a linear accelerator, in fact, particles are sent to the patient in bunches with a rate of 150-300 Hz depending on the beam type and energy. The neutron spectrum is usually measured with integrating detectors such as bubble dosimeters or TLDs, which integrate over a time interval and an energy one. We are developing a scintillator detector to measure the neutron spectrum in real time in the interval between bunches, that is in the thermal region. The signals from the scintillator are discriminated and sampled by a dedicated clock in a Cyclone II FPGA by Altera, thus obtaining the neutron time of flight spectrum. The exploited physical process in ordinary plastic scintillators is neutron capture by H with a subsequent γ emission. The measured TOF spectrum has been compared with a BF 3 counter one. A dedicated simulation with MCNP is being developed to extract the energy spectrum from the TOF one. The paper will present the results of the prototype measurements and the status of the simulation.

Doppler velocity measurements from large and small arteries of mice

PubMed Central

Reddy, Anilkumar K.; Madala, Sridhar; Entman, Mark L.; Michael, Lloyd H.; Taffet, George E.

2011-01-01

With the growth of genetic engineering, mice have become increasingly common as models of human diseases, and this has stimulated the development of techniques to assess the murine cardiovascular system. Our group has developed nonimaging and dedicated Doppler techniques for measuring blood velocity in the large and small peripheral arteries of anesthetized mice. We translated technology originally designed for human vessels for use in smaller mouse vessels at higher heart rates by using higher ultrasonic frequencies, smaller transducers, and higher-speed signal processing. With these methods one can measure cardiac filling and ejection velocities, velocity pulse arrival times for determining pulse wave velocity, peripheral blood velocity and vessel wall motion waveforms, jet velocities for the calculation of the pressure drop across stenoses, and left main coronary velocity for the estimation of coronary flow reserve. These noninvasive methods are convenient and easy to apply, but care must be taken in interpreting measurements due to Doppler sample volume size and angle of incidence. Doppler methods have been used to characterize and evaluate numerous cardiovascular phenotypes in mice and have been particularly useful in evaluating the cardiac and vascular remodeling that occur following transverse aortic constriction. Although duplex ultrasonic echo-Doppler instruments are being applied to mice, dedicated Doppler systems are more suitable for some applications. The magnitudes and waveforms of blood velocities from both cardiac and peripheral sites are similar in mice and humans, such that much of what is learned using Doppler technology in mice may be translated back to humans. PMID:21572013

Faint Debris Detection by Particle Based Track-Before-Detect Method

NASA Astrophysics Data System (ADS)

Uetsuhara, M.; Ikoma, N.

2014-09-01

This study proposes a particle method to detect faint debris, which is hardly seen in single frame, from an image sequence based on the concept of track-before-detect (TBD). The most widely used detection method is detect-before-track (DBT), which firstly detects signals of targets from single frame by distinguishing difference of intensity between foreground and background then associate the signals for each target between frames. DBT is capable of tracking bright targets but limited. DBT is necessary to consider presence of false signals and is difficult to recover from false association. On the other hand, TBD methods try to track targets without explicitly detecting the signals followed by evaluation of goodness of each track and obtaining detection results. TBD has an advantage over DBT in detecting weak signals around background level in single frame. However, conventional TBD methods for debris detection apply brute-force search over candidate tracks then manually select true one from the candidates. To reduce those significant drawbacks of brute-force search and not-fully automated process, this study proposes a faint debris detection algorithm by a particle based TBD method consisting of sequential update of target state and heuristic search of initial state. The state consists of position, velocity direction and magnitude, and size of debris over the image at a single frame. The sequential update process is implemented by a particle filter (PF). PF is an optimal filtering technique that requires initial distribution of target state as a prior knowledge. An evolutional algorithm (EA) is utilized to search the initial distribution. The EA iteratively applies propagation and likelihood evaluation of particles for the same image sequences and resulting set of particles is used as an initial distribution of PF. This paper describes the algorithm of the proposed faint debris detection method. The algorithm demonstrates performance on image sequences acquired during observation campaigns dedicated to GEO breakup fragments, which would contain a sufficient number of faint debris images. The results indicate the proposed method is capable of tracking faint debris with moderate computational costs at operational level.

Investigating precipitation changes of anthropic origin: data and methodological issues

NASA Astrophysics Data System (ADS)

de Lima, Isabel; Lovejoy, Shaun

2017-04-01

There is much concern about the social, environmental and economic impacts of climate change that could result directly from changes in temperature and precipitation. For temperature, the situation is better understood; but despite the many studies that have been already dedicated to precipitation, change in this process - that could be associated to the transition to the Anthropocene - has not yet been convincingly proven. A large fraction of those studies have been exploring temporal (linear) trends in local precipitation, sometimes using records over only a few decades; other fewer studies have been dedicated to investigating global precipitation change. Overall, precipitation change of anthropic origin has showed to be difficult to establish with high statistical significance and, moreover, different data and products have displayed important discrepancies; this is valid even for global precipitation. We argue that the inadequate resolution and length of the data commonly used, as well as methodological issues, are among the main factors limiting the ability to identify the signature of change in precipitation. We propose several ways in which one can hope to improve the situation - or at least - clarify the difficulties. From the point of view of statistical analysis, the problem is one of detecting a low frequency anthropogenic signal in the presence of "noise" - the natural variability (the latter includes both internal dynamics and responses to volcanic, solar or other natural forcings). A consequence is that as one moves to longer and longer time scales, fluctuations are increasingly averaged and at some point, the anthropogenic signal will stand out above the natural variability noise. This approach can be systematized using scaling fluctuation analysis to characterizing different precipitation scaling regimes: weather, macroweather, climate - from higher to lower frequencies; in the anthropocene, the macroweather regime covers the range of time scales from about a month to ≈30 years. We illustrate this using local gauge data and three qualitatively different global scale precipitation products (from gauges, reanalyses and a satellite and gauge hybrid) that allow to investigate precipitation from monthly to centennial scales and in space from planetary down to 5°x5° scales. By systematically characterizing precipitation variability across wide ranges of time and space scales, we show that the anthropogenic signal only exceeded the natural variability at time scales larger than ≈20 years, so that the disagreement in the trends can be traced to these low frequencies.

Calibration of Galileo signals for time metrology.

PubMed

Defraigne, Pascale; Aerts, Wim; Cerretto, Giancarlo; Cantoni, Elena; Sleewaegen, Jean-Marie

2014-12-01

Using global navigation satellite system (GNSS) signals for accurate timing and time transfer requires the knowledge of all electric delays of the signals inside the receiving system. GNSS stations dedicated to timing or time transfer are classically calibrated only for Global Positioning System (GPS) signals. This paper proposes a procedure to determine the hardware delays of a GNSS receiving station for Galileo signals, once the delays of the GPS signals are known. This approach makes use of the broadcast satellite inter-signal biases, and is based on the ionospheric delay measured from dual-frequency combinations of GPS and Galileo signals. The uncertainty on the so-determined hardware delays is estimated to 3.7 ns for each isolated code in the L5 frequency band, and 4.2 ns for the ionosphere-free combination of E1 with a code of the L5 frequency band. For the calibration of a time transfer link between two stations, another approach can be used, based on the difference between the common-view time transfer results obtained with calibrated GPS data and with uncalibrated Galileo data. It is shown that the results obtained with this approach or with the ionospheric method are equivalent.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, W.; Yin, J.; Li, C.

This paper presents a novel front-end electronics based on a front-end ASIC with post digital filtering and calibration dedicated to CZT detectors for PET imaging. A cascade amplifier based on split-leg topology is selected to realize the charge-sensitive amplifier (CSA) for the sake of low noise performances and the simple scheme of the power supplies. The output of the CSA is connected to a variable-gain amplifier to generate the compatible signals for the A/D conversion. A multi-channel single-slope ADC is designed to sample multiple points for the digital filtering and shaping. The digital signal processing algorithms are implemented by amore » FPGA. To verify the proposed scheme, a front-end readout prototype ASIC is designed and implemented in 0.35 μm CMOS process. In a single readout channel, a CSA, a VGA, a 10-bit ADC and registers are integrated. Two dummy channels, bias circuits, and time controller are also integrated. The die size is 2.0 mm x 2.1 mm. The input range of the ASIC is from 2000 e{sup -} to 100000 e{sup -}, which is suitable for the detection of the X-and gamma ray from 11.2 keV to 550 keV. The linearity of the output voltage is less than 1 %. The gain of the readout channel is 40.2 V/pC. The static power dissipation is about 10 mW/channel. The above tested results show that the electrical performances of the ASIC can well satisfy PET imaging applications. (authors)« less

High-rate RTK and PPP multi-GNSS positioning for small-scale dynamic displacements monitoring

NASA Astrophysics Data System (ADS)

Paziewski, Jacek; Sieradzki, Rafał; Baryła, Radosław; Wielgosz, Pawel

2017-04-01

The monitoring of dynamic displacements and deformations of engineering structures such as buildings, towers and bridges is of great interest due to several practical and theoretical reasons. The most important is to provide information required for safe maintenance of the constructions. High temporal resolution and precision of GNSS observations predestine this technology to be applied to most demanding application in terms of accuracy, availability and reliability. GNSS technique supported by appropriate processing methodology may meet the specific demands and requirements of ground and structures monitoring. Thus, high-rate multi-GNSS signals may be used as reliable source of information on dynamic displacements of ground and engineering structures, also in real time applications. In this study we present initial results of application of precise relative GNSS positioning for detection of small scale (cm level) high temporal resolution dynamic displacements. Methodology and algorithms applied in self-developed software allowing for relative positioning using high-rate dual-frequency phase and pseudorange GPS+Galileo observations are also given. Additionally, an approach was also made to use the Precise Point Positioning technique to such application. In the experiment were used the observations obtained from high-rate (20 Hz) geodetic receivers. The dynamic displacements were simulated using specially constructed device moving GNSS antenna with dedicated amplitude and frequency. The obtained results indicate on possibility of detection of dynamic displacements of the GNSS antenna even at the level of few millimetres using both relative and Precise Point Positioning techniques after suitable signals processing.

Multi-channel imaging cytometry with a single detector

NASA Astrophysics Data System (ADS)

Locknar, Sarah; Barton, John; Entwistle, Mark; Carver, Gary; Johnson, Robert

2018-02-01

Multi-channel microscopy and multi-channel flow cytometry generate high bit data streams. Multiple channels (both spectral and spatial) are important in diagnosing diseased tissue and identifying individual cells. Omega Optical has developed techniques for mapping multiple channels into the time domain for detection by a single high gain, high bandwidth detector. This approach is based on pulsed laser excitation and a serial array of optical fibers coated with spectral reflectors such that up to 15 wavelength bins are sequentially detected by a single-element detector within 2.5 μs. Our multichannel microscopy system uses firmware running on dedicated DSP and FPGA chips to synchronize the laser, scanning mirrors, and sampling clock. The signals are digitized by an NI board into 14 bits at 60MHz - allowing for 232 by 174 pixel fields in up to 15 channels with 10x over sampling. Our multi-channel imaging cytometry design adds channels for forward scattering and back scattering to the fluorescence spectral channels. All channels are detected within the 2.5 μs - which is compatible with fast cytometry. Going forward, we plan to digitize at 16 bits with an A-toD chip attached to a custom board. Processing these digital signals in custom firmware would allow an on-board graphics processing unit to display imaging flow cytometry data over configurable scanning line lengths. The scatter channels can be used to trigger data buffering when a cell is present in the beam. This approach enables a low cost mechanically robust imaging cytometer.

The coming of age of the first hybrid metrology software platform dedicated to nanotechnologies (Conference Presentation)

NASA Astrophysics Data System (ADS)

Foucher, Johann; Labrosse, Aurelien; Dervillé, Alexandre; Zimmermann, Yann; Bernard, Guilhem; Martinez, Sergio; Grönqvist, Hanna; Baderot, Julien; Pinzan, Florian

2017-03-01

The development and integration of new materials and structures at the nanoscale require multiple parallel characterizations in order to control mostly physico-chemical properties as a function of applications. Among all properties, we can list physical properties such as: size, shape, specific surface area, aspect ratio, agglomeration/aggregation state, size distribution, surface morphology/topography, structure (including crystallinity and defect structure), solubility and chemical properties such as: structural formula/molecular structure, composition (including degree of purity, known impurities or additives), phase identity, surface chemistry (composition, charge, tension, reactive sites, physical structure, photocatalytic properties, zeta potential), hydrophilicity/lipophilicity. Depending on the final material formulation (aerosol, powder, nanostructuration…) and the industrial application (semiconductor, cosmetics, chemistry, automotive…), a fleet of complementary characterization equipments must be used in synergy for accurate process tuning and high production yield. The synergy between equipment so-called hybrid metrology consists in using the strength of each technique in order to reduce the global uncertainty for better and faster process control. The only way to succeed doing this exercise is to use data fusion methodology. In this paper, we will introduce the work that has been done to create the first generic hybrid metrology software platform dedicated to nanotechnologies process control. The first part will be dedicated to process flow modeling that is related to a fleet of metrology tools. The second part will introduce the concept of entity model which describes the various parameters that have to be extracted. The entity model is fed with data analysis as a function of the application (automatic analysis or semi-automated analysis). The final part will introduce two ways of doing data fusion on real data coming from imaging (SEM, TEM, AFM) and non-imaging techniques (SAXS). First approach is dedicated to high level fusion which is the art of combining various populations of results from homogeneous or heterogeneous tools, taking into account precision and repeatability of each of them to obtain a new more accurate result. The second approach is dedicated to deep level fusion which is the art of combining raw data from various tools in order to create a new raw data. We will introduce a new concept of virtual tool creator based on deep level fusion. As a conclusion we will discuss the implementation of hybrid metrology in semiconductor environment for advanced process control

Narrow Angle Diversity using ACTS Ka-band Signal with Two USAT Ground Stations

NASA Technical Reports Server (NTRS)

Kalu, A.; Emrich, C.; Ventre, J.; Wilson, W.; Acosta, R.

1998-01-01

Two ultra small aperture terminal (USAT) ground stations, separated by 1.2 km in a narrow angle diversity configuration, received a continuous Ka-band tone sent from Cleveland Link Evaluation Terminal (LET). The signal was transmitted to the USAT ground stations via NASA's Advanced Communications Technology Satellite (ACTS) steerable beam. Received signal power at the two sites was measured and analyzed. A dedicated datalogger at each site recorded time-of-tip data from tipping bucket rain gauges, providing rain amount and instantaneous rain rate. WSR-88D data was also obtained for the collection period. Eleven events with ground-to-satellite slant-path precipitation and resultant signal attenuation were observed during the data collection period. Fade magnitude and duration were compared at the two sites and diversity gain was calculated. These results exceeded standard diversity gain model predictions by several decibels. Rain statistics from tipping bucket data and from radar data were also compared to signal attenuation. The nature of Florida's subtropical rainfall, specifically its impact on signal attenuation at the sites, was addressed.

A decade of SETI observations

NASA Technical Reports Server (NTRS)

Dixon, R. S.

1986-01-01

A full time dedicated search for extraterrestrial radio signals of intelligent origin has been in progress at the Ohio State University Radio Observatory since 1973. The radio telescope has a collecting area of 2200 square meters, which is equivalent to a circular dish 175 feet in diameter. The search concentrates on a 500 kHz bandwidth centered on the 1420 MHz hydrogen line, Doppler corrected to the galactic standard of rest. A large portion of the sky visible from Ohio was searched, with particulat emphasis on the galactic center region and the M31 Andromeda galaxy. The survey is largely computer automated, and all data reduction is done in real time. Two distinct populations of signals were detected. The first is a relatively small number of signals which persist for over a minute and which are clearly extraterrestrial in origin. The second is the large number of signals which persist less than 10 seconds whose locations are anticorrelated with the galactic plane but show clumps along the galactic axis. None of these signals were observed to recur, despite repeated observations. The cause of these signals were not determined.

Academic Outcome Measures of a Dedicated Education Unit Over Time: Help or Hinder?

PubMed

Smyer, Tish; Gatlin, Tricia; Tan, Rhigel; Tejada, Marianne; Feng, Du

2015-01-01

Critical thinking, nursing process, quality and safety measures, and standardized RN exit examination scores were compared between students (n = 144) placed in a dedicated education unit (DEU) and those in a traditional clinical model. Standardized test scores showed that differences between the clinical groups were not statistically significant. This study shows that the DEU model is 1 approach to clinical education that can enhance students' academic outcomes.

Extreme-Environment Silicon-Carbide (SiC) Wireless Sensor Suite

NASA Technical Reports Server (NTRS)

Yang, Jie

2015-01-01

Phase II objectives: Develop an integrated silicon-carbide wireless sensor suite capable of in situ measurements of critical characteristics of NTP engine; Compose silicon-carbide wireless sensor suite of: Extreme-environment sensors center, Dedicated high-temperature (450 deg C) silicon-carbide electronics that provide power and signal conditioning capabilities as well as radio frequency modulation and wireless data transmission capabilities center, An onboard energy harvesting system as a power source.

Design, Implementation, and Characterization of a Dedicated Breast Computed MammoTomography System for Enhanced Lesion Imaging

DTIC Science & Technology

2008-03-01

dual view mammography with anticipated increased image contrast ; and (4) expectedly improved positive predictive value, especially for...ray source allows for reduced radiation dose as compared to standard dual-view mammography and additionally improves image contrast between soft...clear signal enhancing ~2cm diameter, detailed volume of tracer anterior to the chest wall which corresponded to that seen in the contrast enhanced

Generic controller dedicated to telemetry-controlled microsystems.

PubMed

Sodagar, Amir M; Wise, Kensall D; Najafi, Khalil

2006-01-01

This paper introduces a generic controller designed for telemetry-controlled microsystems. This controller receives a data packet through a serial link carrying a command word and the associated data, and is capable of generating a variety of control/timing signals according to the definition of the received command. The flexible microprogrammed architecture of the controller allows for defining the commands functions in an on-chip mask-programmable read-only memory.

Near-Infrared Scintillation of Liquid Argon: Recent Results Obtained with the NIR Facility at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Escobar, C. O.; Rubinov, P.; Tilly, E.

After a short review of previous attempts to observe and measure the near-infrared scintillation in liquid argon, we present new results obtained with NIR, a dedicated cryostat at the Fermilab Proton Assembly Building (PAB). The new results give confidence that the near-infrared light can be used as the much needed light signal in large liquid argon time projection chambers.11 pages,

A low-power current-reuse dual-band analog front-end for multi-channel neural signal recording.

PubMed

Sepehrian, H; Gosselin, B

2014-01-01

Thoroughly studying the brain activity of freely moving subjects requires miniature data acquisition systems to measure and wirelessly transmit neural signals in real time. In this application, it is mandatory to simultaneously record the bioelectrical activity of a large number of neurons to gain a better knowledge of brain functions. However, due to limitations in transferring the entire raw data to a remote base station, employing dedicated data reduction techniques to extract the relevant part of neural signals is critical to decrease the amount of data to transfer. In this work, we present a new dual-band neural amplifier to separate the neuronal spike signals (SPK) and the local field potential (LFP) simultaneously in the analog domain, immediately after the pre-amplification stage. By separating these two bands right after the pre-amplification stage, it is possible to process LFP and SPK separately. As a result, the required dynamic range of the entire channel, which is determined by the signal-to-noise ratio of the SPK signal of larger bandwidth, can be relaxed. In this design, a new current-reuse low-power low-noise amplifier and a new dual-band filter that separates SPK and LFP while saving capacitors and pseudo resistors. A four-channel dual-band (SPK, LFP) analog front-end capable of simultaneously separating SPK and LFP is implemented in a TSMC 0.18 μm technology. Simulation results present a total power consumption per channel of 3.1 μw for an input referred noise of 3.28 μV and a NEF for 2.07. The cutoff frequency of the LFP band is fc=280 Hz, and fL=725 Hz and fL=11.2 KHz for SPK, with 36 dB gain for LFP band 46 dB gain for SPK band.

Using Mosix for Wide-Area Compuational Resources

USGS Publications Warehouse

Maddox, Brian G.

2004-01-01

One of the problems with using traditional Beowulf-type distributed processing clusters is that they require an investment in dedicated computer resources. These resources are usually needed in addition to pre-existing ones such as desktop computers and file servers. Mosix is a series of modifications to the Linux kernel that creates a virtual computer, featuring automatic load balancing by migrating processes from heavily loaded nodes to less used ones. An extension of the Beowulf concept is to run a Mosixenabled Linux kernel on a large number of computer resources in an organization. This configuration would provide a very large amount of computational resources based on pre-existing equipment. The advantage of this method is that it provides much more processing power than a traditional Beowulf cluster without the added costs of dedicating resources.

Cognitive processes and neural basis of language switching: proposal of a new model.

PubMed

Moritz-Gasser, Sylvie; Duffau, Hugues

2009-12-09

Although studies on bilingualism are abundant, cognitive processes and neural foundations of language switching received less attention. The aim of our study is to provide new insights to this still open question: do dedicated region(s) for language switching exist or is this function underlain by a distributed circuit of interconnected brain areas, part of a more general cognitive system? On the basis of recent behavioral, neuroimaging, and brain stimulation studies, we propose an original 'hodological' model of language switching. This process might be subserved by a large-scale cortico-subcortical network, with an executive system (prefrontal cortex, anterior cingulum, caudate nucleus) controlling a more dedicated language subcircuit, which involves postero-temporal areas, supramarginal and angular gyri, Broca's area, and the superior longitudinal fasciculus.

Multiple-mouse MRI with multiple arrays of receive coils.

PubMed

Ramirez, Marc S; Esparza-Coss, Emilio; Bankson, James A

2010-03-01

Compared to traditional single-animal imaging methods, multiple-mouse MRI has been shown to dramatically improve imaging throughput and reduce the potentially prohibitive cost for instrument access. To date, up to a single radiofrequency coil has been dedicated to each animal being simultaneously scanned, thus limiting the sensitivity, flexibility, and ultimate throughput. The purpose of this study was to investigate the feasibility of multiple-mouse MRI with a phased-array coil dedicated to each animal. A dual-mouse imaging system, consisting of a pair of two-element phased-array coils, was developed and used to achieve acceleration factors greater than the number of animals scanned at once. By simultaneously scanning two mice with a retrospectively gated cardiac cine MRI sequence, a 3-fold acceleration was achieved with signal-to-noise ratio in the heart that is equivalent to that achieved with an unaccelerated scan using a commercial mouse birdcage coil. (c) 2010 Wiley-Liss, Inc.

Process Hood Stand Support Steel

DOE Office of Scientific and Technical Information (OSTI.GOV)

VAN KATWIJK, C.

2000-04-03

This package is written to comply with EN-6-035-00 for upgrade dedication of commercial grade items (CGI). The SNF-5953 CGI package provides the Technical evaluation to identify the critical characteristics and the acceptance criteria associated with the safety function of the Hood Stand Support Steel. Completion of the technical and quality requirements identified in the dedication package will provide enough data to be reasonably assured that CGI Hood Stand Support Steel will perform its SC function.

An Analysis of the Performance-Based Service Acquisition (PBSA) and Its Applicability to Hellenic Navy Service Acquisition Activities

DTIC Science & Technology

2012-12-01

potential offeror in response to its request must not be disclosed if doing so would reveal the potential offeror’s confidential business strategy...also the Navy Academy and the Navy hospital have and operate kitchen facilities. Ships have their own kitchen facilities too and dedicated personnel...abandoned. Now the HN dedicates personnel, has kitchen facilities to provide the food services and doing the whole process. The HN could outsource

A minimum spanning forest based classification method for dedicated breast CT images

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pike, Robert; Sechopoulos, Ioannis; Fei, Baowei, E-mail: bfei@emory.edu

Purpose: To develop and test an automated algorithm to classify different types of tissue in dedicated breast CT images. Methods: Images of a single breast of five different patients were acquired with a dedicated breast CT clinical prototype. The breast CT images were processed by a multiscale bilateral filter to reduce noise while keeping edge information and were corrected to overcome cupping artifacts. As skin and glandular tissue have similar CT values on breast CT images, morphologic processing is used to identify the skin based on its position information. A support vector machine (SVM) is trained and the resulting modelmore » used to create a pixelwise classification map of fat and glandular tissue. By combining the results of the skin mask with the SVM results, the breast tissue is classified as skin, fat, and glandular tissue. This map is then used to identify markers for a minimum spanning forest that is grown to segment the image using spatial and intensity information. To evaluate the authors’ classification method, they use DICE overlap ratios to compare the results of the automated classification to those obtained by manual segmentation on five patient images. Results: Comparison between the automatic and the manual segmentation shows that the minimum spanning forest based classification method was able to successfully classify dedicated breast CT image with average DICE ratios of 96.9%, 89.8%, and 89.5% for fat, glandular, and skin tissue, respectively. Conclusions: A 2D minimum spanning forest based classification method was proposed and evaluated for classifying the fat, skin, and glandular tissue in dedicated breast CT images. The classification method can be used for dense breast tissue quantification, radiation dose assessment, and other applications in breast imaging.« less

PepsNMR for 1H NMR metabolomic data pre-processing.

PubMed

Martin, Manon; Legat, Benoît; Leenders, Justine; Vanwinsberghe, Julien; Rousseau, Réjane; Boulanger, Bruno; Eilers, Paul H C; De Tullio, Pascal; Govaerts, Bernadette

2018-08-17

In the analysis of biological samples, control over experimental design and data acquisition procedures alone cannot ensure well-conditioned 1 H NMR spectra with maximal information recovery for data analysis. A third major element affects the accuracy and robustness of results: the data pre-processing/pre-treatment for which not enough attention is usually devoted, in particular in metabolomic studies. The usual approach is to use proprietary software provided by the analytical instruments' manufacturers to conduct the entire pre-processing strategy. This widespread practice has a number of advantages such as a user-friendly interface with graphical facilities, but it involves non-negligible drawbacks: a lack of methodological information and automation, a dependency of subjective human choices, only standard processing possibilities and an absence of objective quality criteria to evaluate pre-processing quality. This paper introduces PepsNMR to meet these needs, an R package dedicated to the whole processing chain prior to multivariate data analysis, including, among other tools, solvent signal suppression, internal calibration, phase, baseline and misalignment corrections, bucketing and normalisation. Methodological aspects are discussed and the package is compared to the gold standard procedure with two metabolomic case studies. The use of PepsNMR on these data shows better information recovery and predictive power based on objective and quantitative quality criteria. Other key assets of the package are workflow processing speed, reproducibility, reporting and flexibility, graphical outputs and documented routines. Copyright © 2018 Elsevier B.V. All rights reserved.

An attempt to model the human body as a communication channel.

PubMed

Wegmueller, Marc Simon; Kuhn, Andreas; Froehlich, Juerg; Oberle, Michael; Felber, Norbert; Kuster, Niels; Fichtner, Wolfgang

2007-10-01

Using the human body as a transmission medium for electrical signals offers novel data communication in biomedical monitoring systems. In this paper, galvanic coupling is presented as a promising approach for wireless intra-body communication between on-body sensors. The human body is characterized as a transmission medium for electrical current by means of numerical simulations and measurements. Properties of dedicated tissue layers and geometrical body variations are investigated, and different electrodes are compared. The new intra-body communication technology has shown its feasibility in clinical trials. Excellent transmission was achieved between locations on the thorax with a typical signal-to-noise ratio (SNR) of 20 dB while the attenuation increased along the extremities.

Efficient optical cloud removal technique for earth observation based on MOEMs device

NASA Astrophysics Data System (ADS)

Zamkotsian, Frédéric; Lanzoni, Patrick; Liotard, Arnaud; Viard, Thierry; Noell, Wilfried

2017-11-01

In Earth Observation instruments, observation of scenes including bright sources leads to an important degradation of the recorded signal. We propose a new concept to remove dynamically the bright sources and then obtain a field of view with an optically enhanced Signal-to-Noise Ratio (SNR). Micro-Opto-Electro-Mechanical Systems (MOEMS) could be key components in future generation of space instruments. MOEMS-based programmable slit masks will permit the straylight control in future Earth Observation instruments. Experimental demonstration of this concept has been conducted on a dedicated bench. This successful first demonstration shows the high potential of this new concept in future spectro-imager for Earth Observation.

Allosteric Modulation of Chemoattractant Receptors

PubMed Central

Allegretti, Marcello; Cesta, Maria Candida; Locati, Massimo

2016-01-01

Chemoattractants control selective leukocyte homing via interactions with a dedicated family of related G protein-coupled receptor (GPCR). Emerging evidence indicates that the signaling activity of these receptors, as for other GPCR, is influenced by allosteric modulators, which interact with the receptor in a binding site distinct from the binding site of the agonist and modulate the receptor signaling activity in response to the orthosteric ligand. Allosteric modulators have a number of potential advantages over orthosteric agonists/antagonists as therapeutic agents and offer unprecedented opportunities to identify extremely selective drug leads. Here, we resume evidence of allosterism in the context of chemoattractant receptors, discussing in particular its functional impact on functional selectivity and probe/concentration dependence of orthosteric ligands activities. PMID:27199992

Simulations of extragalactic magnetic fields and of their observables

NASA Astrophysics Data System (ADS)

Vazza, F.; Brüggen, M.; Gheller, C.; Hackstein, S.; Wittor, D.; Hinz, P. M.

2017-12-01

The origin of extragalactic magnetic fields is still poorly understood. Based on a dedicated suite of cosmological magneto-hydrodynamical simulations with the ENZO code we have performed a survey of different models that may have caused present-day magnetic fields in galaxies and galaxy clusters. The outcomes of these models differ in cluster outskirts, filaments, sheets and voids and we use these simulations to find observational signatures of magnetogenesis. With these simulations, we predict the signal of extragalactic magnetic fields in radio observations of synchrotron emission from the cosmic web, in Faraday rotation, in the propagation of ultra high energy cosmic rays, in the polarized signal from fast radio bursts at cosmological distance and in spectra of distant blazars. In general, primordial scenarios in which present-day magnetic fields originate from the amplification of weak (⩽nG ) uniform seed fields result in more homogeneous and relatively easier to observe magnetic fields than astrophysical scenarios, in which present-day fields are the product of feedback processes triggered by stars and active galaxies. In the near future the best evidence for the origin of cosmic magnetic fields will most likely come from a combination of synchrotron emission and Faraday rotation observed at the periphery of large-scale structures.

A Next Generation Digital Counting System For Low-Level Tritium Studies (Project Report)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bowman, P.

2016-10-03

Since the early seventies, SRNL has pioneered low-level tritium analysis using various nuclear counting technologies and techniques. Since 1999, SRNL has successfully performed routine low-level tritium analyses with counting systems based on digital signal processor (DSP) modules developed in the late 1990s. Each of these counting systems are complex, unique to SRNL, and fully dedicated to performing routine tritium analyses of low-level environmental samples. It is time to modernize these systems due to a variety of issues including (1) age, (2) lack of direct replacement electronics modules and (3) advances in digital signal processing and computer technology. There has beenmore » considerable development in many areas associated with the enterprise of performing low-level tritium analyses. The objective of this LDRD project was to design, build, and demonstrate a Next Generation Tritium Counting System (NGTCS), while not disrupting the routine low-level tritium analyses underway in the facility on the legacy counting systems. The work involved (1) developing a test bed for building and testing new counting system hardware that does not interfere with our routine analyses, (2) testing a new counting system based on a modern state of the art DSP module, and (3) evolving the low-level tritium counter design to reflect the state of the science.« less

A multi-frequency impedance analysing instrument for eddy current testing

NASA Astrophysics Data System (ADS)

Yin, W.; Dickinson, S. J.; Peyton, A. J.

2006-02-01

This paper presents the design of a high-performance multi-frequency impedance analysing instrument (MFIA) for eddy current testing which has been developed primarily for monitoring a steel production process using an inductive sensor. The system consists of a flexible multi-frequency waveform generator and a voltage/current measurement unit. The impedance of the sensor is obtained by cross-spectral analysis of the current and voltage signals. The system contains high-speed digital-to-analogue, analogue-to-digital converters and dual DSPs with one for control and interface and one dedicated to frequency-spectra analysis using fast Fourier transformation (FFT). The frequency span of the signal that can be analysed ranges from 1 kHz to 8 MHz. The system also employs a high-speed serial port interface (USB) to communicate with a personal computer (PC) and to allow for fast transmission of data and control commands. Overall, the system is capable of delivering over 250 impedance spectra per second. Although the instrument has been developed mainly for use with an inductive sensor, the system is not restricted to inductive measurement. The flexibility of the design architecture is demonstrated with capacitive and resistive measurements by using appropriate input circuitry. Issues relating to optimizing the phase of the spectra components in the excitation waveform are also discussed.

Why translation counts for mitochondria - retrograde signalling links mitochondrial protein synthesis to mitochondrial biogenesis and cell proliferation.

PubMed

Battersby, Brendan J; Richter, Uwe

2013-10-01

Organelle biosynthesis is a key requirement for cell growth and division. The regulation of mitochondrial biosynthesis exhibits additional layers of complexity compared with that of other organelles because they contain their own genome and dedicated ribosomes. Maintaining these components requires gene expression to be coordinated between the nucleo-cytoplasmic compartment and mitochondria in order to monitor organelle homeostasis and to integrate the responses to the physiological and developmental demands of the cell. Surprisingly, the parameters that are used to monitor or count mitochondrial abundance are not known, nor are the signalling pathways. Inhibiting the translation on mito-ribosomes genetically or with antibiotics can impair cell proliferation and has been attributed to defects in aerobic energy metabolism, even though proliferating cells rely primarily on glycolysis to fuel their metabolic demands. However, a recent study indicates that mitochondrial translational stress and the rescue mechanisms that relieve this stress cause the defect in cell proliferation and occur before any impairment of oxidative phosphorylation. Therefore, the process of mitochondrial translation in itself appears to be an important checkpoint for the monitoring of mitochondrial homeostasis and might have a role in establishing mitochondrial abundance within a cell. This hypothesis article will explore the evidence supporting a role for mito-ribosomes and translation in a mitochondria-counting mechanism.

Discriminative Ocular Artifact Correction for Feature Learning in EEG Analysis.

PubMed

Xinyang Li; Cuntai Guan; Haihong Zhang; Kai Keng Ang

2017-08-01

Electrooculogram (EOG) artifact contamination is a common critical issue in general electroencephalogram (EEG) studies as well as in brain-computer interface (BCI) research. It is especially challenging when dedicated EOG channels are unavailable or when there are very few EEG channels available for independent component analysis based ocular artifact removal. It is even more challenging to avoid loss of the signal of interest during the artifact correction process, where the signal of interest can be multiple magnitudes weaker than the artifact. To address these issues, we propose a novel discriminative ocular artifact correction approach for feature learning in EEG analysis. Without extra ocular movement measurements, the artifact is extracted from raw EEG data, which is totally automatic and requires no visual inspection of artifacts. Then, artifact correction is optimized jointly with feature extraction by maximizing oscillatory correlations between trials from the same class and minimizing them between trials from different classes. We evaluate this approach on a real-world EEG dataset comprising 68 subjects performing cognitive tasks. The results showed that the approach is capable of not only suppressing the artifact components but also improving the discriminative power of a classifier with statistical significance. We also demonstrate that the proposed method addresses the confounding issues induced by ocular movements in cognitive EEG study.

A USNRC perspective on the use of commercial-off-shelf software (COTS) in advanced reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stewart, J.C.

1997-12-01

The use of commercially available digital computer systems and components in safety critical systems (nuclear power plant, military, and commercial applications) is increasing rapidly. While this paper focuses on the software aspects of the application most of these continents are applicable to the hardware aspects as well. Commercial dedication (the process of assuring that a commercial grade item will perform its intended safety function) has demonstrated benefits in cost savings and a wide base of user experience, however, care must be taken to avoid difficulties with some aspects of the dedication process such as access to vendor development information, configurationmore » management long term support, and system integration.« less

Comparative Activity-Based Flavin-Dependent Oxidase Profiling.

PubMed

Krysiak, Joanna; Breinbauer, Rolf

2017-01-01

Activity-based protein profiling (ABPP) has become a powerful chemoproteomic technology allowing for the dissection of complex ligand-protein interactions in their native cellular environment. One of the biggest challenges for ABPP is the extension of the proteome coverage. In this chapter a new ABPP strategy dedicated to monoamine oxidases (MAO) is presented. These enzymes are representative examples of flavin-dependent oxidases, playing a crucial role in the regulation of nervous system signaling.

An Airborne Ultrasonic Imaging System Based on 16 Elements: 150 kHz Piezopolymer Transducer Arrays—Preliminary Simulated and Experimental Results for Cylindrical Targets Detection

NASA Astrophysics Data System (ADS)

Capineri, L.; Bulletti, A.; Calzolai, M.; Giannelli, P.

2016-12-01

This paper describes the design and fabrication of a 16-element transducer array for airborne ultrasonic imaging operating at 150 kHz, that can operate both at close range (50 mm) in the near field of a synthetic aperture, and up to 250 mm. The proposed imaging technique is based on a modified version of the delay and sum algorithm implemented with a synthetic aperture where each pixel amplitude is determined by the integration of the signal obtained by the coherent summation of the acquired signals over a delayed window with fixed length. The image reconstruction methods using raw data provides the possibility to detect targets with smaller feature size on the order of one wavelength because the coherent signals summation over the selected window length while the image reconstruction methods using the summation of enveloped signals increases the amplitude response at the expenses of a lower spatial resolution. For the implementation of this system it is important to design compact airborne transducers with large field of view and this can be obtained with a new design of hemi-cylindrical polyvinylidene fluoride film transducers directly mounted on a printed circuit board. This new method is low cost and has repeatable transducer characteristics. The complete system is compact, with a modular architecture, in which eight boards with dual ultrasonic channels are mounted on a mother board. Each daughter board hosts a microcontroller unit and can operate with transducers in the bandwidth 40-200 kHz with on-board data acquisition, pre-processing and transfer on a dedicated bus.

A CMOS IC-based multisite measuring system for stimulation and recording in neural preparations in vitro

PubMed Central

Tateno, Takashi; Nishikawa, Jun

2014-01-01

In this report, we describe the system integration of a complementary metal oxide semiconductor (CMOS) integrated circuit (IC) chip, capable of both stimulation and recording of neurons or neural tissues, to investigate electrical signal propagation within cellular networks in vitro. The overall system consisted of three major subunits: a 5.0 × 5.0 mm CMOS IC chip, a reconfigurable logic device (field-programmable gate array, FPGA), and a PC. To test the system, microelectrode arrays (MEAs) were used to extracellularly measure the activity of cultured rat cortical neurons and mouse cortical slices. The MEA had 64 bidirectional (stimulation and recording) electrodes. In addition, the CMOS IC chip was equipped with dedicated analog filters, amplification stages, and a stimulation buffer. Signals from the electrodes were sampled at 15.6 kHz with 16-bit resolution. The measured input-referred circuitry noise was 10.1 μ V root mean square (10 Hz to 100 kHz), which allowed reliable detection of neural signals ranging from several millivolts down to approximately 33 μ Vpp. Experiments were performed involving the stimulation of neurons with several spatiotemporal patterns and the recording of the triggered activity. An advantage over current MEAs, as demonstrated by our experiments, includes the ability to stimulate (voltage stimulation, 5-bit resolution) spatiotemporal patterns in arbitrary subsets of electrodes. Furthermore, the fast stimulation reset mechanism allowed us to record neuronal signals from a stimulating electrode around 3 ms after stimulation. We demonstrate that the system can be directly applied to, for example, auditory neural prostheses in conjunction with an acoustic sensor and a sound processing system. PMID:25346683

A CMOS IC-based multisite measuring system for stimulation and recording in neural preparations in vitro.

PubMed

Tateno, Takashi; Nishikawa, Jun

2014-01-01

In this report, we describe the system integration of a complementary metal oxide semiconductor (CMOS) integrated circuit (IC) chip, capable of both stimulation and recording of neurons or neural tissues, to investigate electrical signal propagation within cellular networks in vitro. The overall system consisted of three major subunits: a 5.0 × 5.0 mm CMOS IC chip, a reconfigurable logic device (field-programmable gate array, FPGA), and a PC. To test the system, microelectrode arrays (MEAs) were used to extracellularly measure the activity of cultured rat cortical neurons and mouse cortical slices. The MEA had 64 bidirectional (stimulation and recording) electrodes. In addition, the CMOS IC chip was equipped with dedicated analog filters, amplification stages, and a stimulation buffer. Signals from the electrodes were sampled at 15.6 kHz with 16-bit resolution. The measured input-referred circuitry noise was 10.1 μ V root mean square (10 Hz to 100 kHz), which allowed reliable detection of neural signals ranging from several millivolts down to approximately 33 μ Vpp. Experiments were performed involving the stimulation of neurons with several spatiotemporal patterns and the recording of the triggered activity. An advantage over current MEAs, as demonstrated by our experiments, includes the ability to stimulate (voltage stimulation, 5-bit resolution) spatiotemporal patterns in arbitrary subsets of electrodes. Furthermore, the fast stimulation reset mechanism allowed us to record neuronal signals from a stimulating electrode around 3 ms after stimulation. We demonstrate that the system can be directly applied to, for example, auditory neural prostheses in conjunction with an acoustic sensor and a sound processing system.

Protein disulfide isomerase and Nox: new partners in redox signaling.

PubMed

Trevelin, Silvia Cellone; Lopes, Lucia Rossetti

2015-01-01

Reactive oxygen species (ROS) contribute to the pathogenesis of cardiovascular disease, including hypertension, atherosclerosis, cardiac hypertrophy, heart failure and restenosis. Thiol proteins and thiol oxidoreductases are key players in cell signaling, and their altered expression and/or activity has been associated with a disrupture in cardiac and vascular homeostasis. Protein disulfide isomerase (PDI) is a thiol oxidoreductase member of the thioredoxin family that has multiple roles in cellular function. Originally discovered in the endoplasmic reticulum (ER), PDI is essential for protein folding. However, it can also be found in the cytosol and closely associated with the surface of platelets, smooth muscle cells, neutrophils and endothelial cells. On the cell surface, PDI is imperative for platelet aggregation and transnitrosation, which are related to thrombosis and control of vascular tone by nitric oxide, respectively. Furthermore, PDI signaling contributes to redox-dependent events such as smooth muscle cell migration induced by PDGF and TNFα-dependent angiogenesis. Studies from our group have shown that intracellular PDI regulates the expression and activity of the NADPH oxidase family of proteins (Nox), which are enzymes dedicated to ROS generation. PDI acts as a new organizer of leukocyte Nox2 by redox dependently associating with p47phox and controlling its recruitment to the plasma membrane, an essential step for assembly of the active enzyme. Such multiple effects of PDI suggest that specific targeting of this oxidoreductase could represent a new approach in the treatment of vascular disease. In this review, we present a novel role for PDI as an adaptor protein involved in redox processes and Nox signaling and propose PDI as a potential therapeutic target in the treatment of atherosclerosis, thrombosis and hypertension.

Multi circular-cavity surface coil for magnetic resonance imaging of monkey's brain at 4 Tesla

NASA Astrophysics Data System (ADS)

Osorio, A. I.; Solis-Najera, S. E.; Vázquez, F.; Wang, R. L.; Tomasi, D.; Rodriguez, A. O.

2014-11-01

Animal models in medical research has been used to study humans diseases for several decades. The use of different imaging techniques together with different animal models offers a great advantage due to the possibility to study some human pathologies without the necessity of chirurgical intervention. The employ of magnetic resonance imaging for the acquisition of anatomical and functional images is an excellent tool because its noninvasive nature. Dedicated coils to perform magnetic resonance imaging experiments are obligatory due to the improvement on the signal-to-noise ratio and reduced specific absorption ratio. A specifically designed surface coil for magnetic resonance imaging of monkey's brain is proposed based on the multi circular-slot coil. Numerical simulations of the magnetic and electric fields were also performed using the Finite Integration Method to solve Maxwell's equations for this particular coil design and, to study the behavior of various vector magnetic field configurations and specific absorption ratio. Monkey's brain images were then acquired with a research-dedicated magnetic resonance imaging system at 4T, to evaluate the anatomical images with conventional imaging sequences. This coil showed good quality images of a monkey's brain and full compatibility with standard pulse sequences implemented in research-dedicated imager.

Design study of dedicated brain PET with polyhedron geometry.

PubMed

Shi, Han; Du, Dong; Xu, JianFeng; Su, Zhihong; Peng, Qiyu

2015-01-01

Despite being the conventional choice, whole body PET cameras with a 76 cm diameter ring are not the optimal means of human brain imaging. In fact, a dedicated brain PET with a better geometrical structure has the potential to achieve a higher sensitivity, a higher signal-to-noise ratio, and a better imaging performance. In this study, a polyhedron geometrical dedicated brain PET (a dodecahedron design) is compared to three other candidates via their geometrical efficiencies by calculating the Solid Angle Fractions (SAF); the three other candidates include a spherical cap design, a cylindrical design, and the conventional whole body PET. The spherical cap and the dodecahedron have an identical SAF that is 58.4% higher than that of a 30 cm diameter cylinder and 5.44 times higher than that of a 76 cm diameter cylinder. The conceptual polygon-shape detectors (including pentagon and hexagon detectors based on the PMT-light-sharing scheme instead of the conventional square-shaped block detector module) are presented for the polyhedron PET design. Monte Carlo simulations are performed in order to validate the detector decoding. The results show that crystals in a pentagon-shape detector can be successfully decoded by Anger Logic. The new detector designs support the polyhedron PET investigation.

Network of dedicated processors for finding lowest-cost map path

NASA Technical Reports Server (NTRS)

Eberhardt, Silvio P. (Inventor)

1991-01-01

A method and associated apparatus are disclosed for finding the lowest cost path of several variable paths. The paths are comprised of a plurality of linked cost-incurring areas existing between an origin point and a destination point. The method comprises the steps of connecting a purality of nodes together in the manner of the cost-incurring areas; programming each node to have a cost associated therewith corresponding to one of the cost-incurring areas; injecting a signal into one of the nodes representing the origin point; propagating the signal through the plurality of nodes from inputs to outputs; reducing the signal in magnitude at each node as a function of the respective cost of the node; and, starting at one of the nodes representing the destination point and following a path having the least reduction in magnitude of the signal from node to node back to one of the nodes representing the origin point whereby the lowest cost path from the origin point to the destination point is found.

Bunch-by-bunch detection of coherent transverse modes from digitized single-bpm signals in the Tevatron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stancari, G.; Valishev, A.; Semenov, A.

2010-05-01

A system was developed for bunch-by-bunch detection of transverse proton and antiproton coherent oscillations based on the signal from a single beam-position monitor (BPM) located in a region of the ring with large amplitude functions. The signal is digitized over a large number of turns and Fourier-analyzed offline with a dedicated algorithm. To enhance the signal, the beam is excited with band-limited noise for about one second, and this was shown not to significantly affect the circulating beams even at high luminosity. The system is used to measure betatron tunes of individual bunches and to study beam-beam effects. In particular,more » it is one of the main diagnostic tools in an ongoing study of nonlinear beam-beam compensation studies with Gaussian electron lenses. We present the design and operation of this tool, together with results obtained with proton and antiproton bunches.« less

Amplifiers dedicated for large area SiC photodiodes

NASA Astrophysics Data System (ADS)

Doroz, P.; Duk, M.; Korwin-Pawlowski, M. L.; Borecki, M.

2016-09-01

Large area SiC photodiodes find applications in optoelectronic sensors working at special conditions. These conditions include detection of UV radiation in harsh environment. Moreover, the mentioned sensors have to be selective and resistant to unwanted signals. For this purpose, the modulation of light at source unit and the rejection of constant current and low frequency component of signal at detector unit are used. The popular frequency used for modulation in such sensor is 1kHz. The large area photodiodes are characterized by a large capacitance and low shunt resistance that varies with polarization of the photodiode and can significantly modify the conditions of signal pre-amplification. In this paper two pre-amplifiers topology are analyzed: the transimpedance amplifier and the non-inverting voltage to voltage amplifier with negative feedback. The feedback loops of both pre-amplifiers are equipped with elements used for initial constant current and low frequency signals rejections. Both circuits are analyzed and compared using simulation and experimental approaches.

Photon-photon scattering at the high-intensity frontier

NASA Astrophysics Data System (ADS)

Gies, Holger; Karbstein, Felix; Kohlfürst, Christian; Seegert, Nico

2018-04-01

The tremendous progress in high-intensity laser technology and the establishment of dedicated high-field laboratories in recent years have paved the way towards a first observation of quantum vacuum nonlinearities at the high-intensity frontier. We advocate a particularly prospective scenario, where three synchronized high-intensity laser pulses are brought into collision, giving rise to signal photons, whose frequency and propagation direction differ from the driving laser pulses, thus providing various means to achieve an excellent signal to background separation. Based on the theoretical concept of vacuum emission, we employ an efficient numerical algorithm which allows us to model the collision of focused high-intensity laser pulses in unprecedented detail. We provide accurate predictions for the numbers of signal photons accessible in experiment. Our study is the first to predict the precise angular spread of the signal photons, and paves the way for a first verification of quantum vacuum nonlinearity in a well-controlled laboratory experiment at one of the many high-intensity laser facilities currently coming online.

Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity.

PubMed

Weng, Jing-Ke; Ye, Mingli; Li, Bin; Noel, Joseph P

2016-08-11

Classically, hormones elicit specific cellular responses by activating dedicated receptors. Nevertheless, the biosynthesis and turnover of many of these hormone molecules also produce chemically related metabolites. These molecules may also possess hormonal activities; therefore, one or more may contribute to the adaptive plasticity of signaling outcomes in host organisms. Here, we show that a catabolite of the plant hormone abscisic acid (ABA), namely phaseic acid (PA), likely emerged in seed plants as a signaling molecule that fine-tunes plant physiology, environmental adaptation, and development. This trait was facilitated by both the emergence-selection of a PA reductase that modulates PA concentrations and by the functional diversification of the ABA receptor family to perceive and respond to PA. Our results suggest that PA serves as a hormone in seed plants through activation of a subset of ABA receptors. This study demonstrates that the co-evolution of hormone metabolism and signaling networks can expand organismal resilience. Copyright © 2016 Elsevier Inc. All rights reserved.

Bioreactors for lignocellulose conversion into fermentable sugars for production of high added value products.

PubMed

Liguori, Rossana; Ventorino, Valeria; Pepe, Olimpia; Faraco, Vincenza

2016-01-01

Lignocellulosic biomasses derived from dedicated crops and agro-industrial residual materials are promising renewable resources for the production of fuels and other added value bioproducts. Due to the tolerance to a wide range of environments, the dedicated crops can be cultivated on marginal lands, avoiding conflict with food production and having beneficial effects on the environment. Besides, the agro-industrial residual materials represent an abundant, available, and cheap source of bioproducts that completely cut out the economical and environmental issues related to the cultivation of energy crops. Different processing steps like pretreatment, hydrolysis and microbial fermentation are needed to convert biomass into added value bioproducts. The reactor configuration, the operative conditions, and the operation mode of the conversion processes are crucial parameters for a high yield and productivity of the biomass bioconversion process. This review summarizes the last progresses in the bioreactor field, with main attention on the new configurations and the agitation systems, for conversion of dedicated energy crops (Arundo donax) and residual materials (corn stover, wheat straw, mesquite wood, agave bagasse, fruit and citrus peel wastes, sunflower seed hull, switchgrass, poplar sawdust, cogon grass, sugarcane bagasse, sunflower seed hull, and poplar wood) into sugars and ethanol. The main novelty of this review is its focus on reactor components and properties.

A high-rate PCI-based telemetry processor system

NASA Astrophysics Data System (ADS)

Turri, R.

2002-07-01

The high performances reached by the Satellite on-board telemetry generation and transmission, as consequently, will impose the design of ground facilities with higher processing capabilities at low cost to allow a good diffusion of these ground station. The equipment normally used are based on complex, proprietary bus and computing architectures that prevent the systems from exploiting the continuous and rapid increasing in computing power available on market. The PCI bus systems now allow processing of high-rate data streams in a standard PC-system. At the same time the Windows NT operating system supports multitasking and symmetric multiprocessing, giving the capability to process high data rate signals. In addition, high-speed networking, 64 bit PCI-bus technologies and the increase in processor power and software, allow creating a system based on COTS products (which in future may be easily and inexpensively upgraded). In the frame of EUCLID RTP 9.8 project, a specific work element was dedicated to develop the architecture of a system able to acquire telemetry data of up to 600 Mbps. Laben S.p.A - a Finmeccanica Company -, entrusted of this work, has designed a PCI-based telemetry system making possible the communication between a satellite down-link and a wide area network at the required rate.

The Performance of the Robo-AO Laser Guide Star Adaptive Optics System at the Kitt Peak 2.1 m Telescope

NASA Astrophysics Data System (ADS)

Jensen-Clem, Rebecca; Duev, Dmitry A.; Riddle, Reed; Salama, Maïssa; Baranec, Christoph; Law, Nicholas M.; Kulkarni, S. R.; Ramprakash, A. N.

2018-01-01

Robo-AO is an autonomous laser guide star adaptive optics (AO) system recently commissioned at the Kitt Peak 2.1 m telescope. With the ability to observe every clear night, Robo-AO at the 2.1 m telescope is the first dedicated AO observatory. This paper presents the imaging performance of the AO system in its first 18 months of operations. For a median seeing value of 1.″44, the average Strehl ratio is 4% in the i\\prime band. After post processing, the contrast ratio under sub-arcsecond seeing for a 2≤slant i\\prime ≤slant 16 primary star is five and seven magnitudes at radial offsets of 0.″5 and 1.″0, respectively. The data processing and archiving pipelines run automatically at the end of each night. The first stage of the processing pipeline shifts and adds the rapid frame rate data using techniques optimized for different signal-to-noise ratios. The second “high-contrast” stage of the pipeline is eponymously well suited to finding faint stellar companions. Currently, a range of scientific programs, including the synthetic tracking of near-Earth asteroids, the binarity of stars in young clusters, and weather on solar system planets are being undertaken with Robo-AO.

Virtualized MME Design for IoT Support in 5G Systems.

PubMed

Andres-Maldonado, Pilar; Ameigeiras, Pablo; Prados-Garzon, Jonathan; Ramos-Munoz, Juan Jose; Lopez-Soler, Juan Manuel

2016-08-22

Cellular systems are recently being considered an option to provide support to the Internet of Things (IoT). To enable this support, the 3rd Generation Partnership Project (3GPP) has introduced new procedures specifically targeted for cellular IoT. With one of these procedures, the transmissions of small and infrequent data packets from/to the devices are encapsulated in signaling messages and sent through the control plane. However, these transmissions from/to a massive number of devices may imply a major increase of the processing load on the control plane entities of the network and in particular on the Mobility Management Entity (MME). In this paper, we propose two designs of an MME based on Network Function Virtualization (NFV) that aim at facilitating the IoT support. The first proposed design partially separates the processing resources dedicated to each traffic class. The second design includes traffic shaping to control the traffic of each class. We consider three classes: Mobile Broadband (MBB), low latency Machine to Machine communications (lM2M) and delay-tolerant M2M communications. Our proposals enable reducing the processing resources and, therefore, the cost. Additionally, results show that the proposed designs lessen the impact between classes, so they ease the compliance of the delay requirements of MBB and lM2M communications.

A Distributed Data Acquisition System for the Sensor Network of the TAWARA_RTM Project

NASA Astrophysics Data System (ADS)

Fontana, Cristiano Lino; Donati, Massimiliano; Cester, Davide; Fanucci, Luca; Iovene, Alessandro; Swiderski, Lukasz; Moretto, Sandra; Moszynski, Marek; Olejnik, Anna; Ruiu, Alessio; Stevanato, Luca; Batsch, Tadeusz; Tintori, Carlo; Lunardon, Marcello

This paper describes a distributed Data Acquisition System (DAQ) developed for the TAWARA_RTM project (TAp WAter RAdioactivity Real Time Monitor). The aim is detecting the presence of radioactive contaminants in drinking water; in order to prevent deliberate or accidental threats. Employing a set of detectors, it is possible to detect alpha, beta and gamma radiations, from emitters dissolved in water. The Sensor Network (SN) consists of several heterogeneous nodes controlled by a centralized server. The SN cyber-security is guaranteed in order to protect it from external intrusions and malicious acts. The nodes were installed in different locations, along the water treatment processes, in the waterworks plant supplying the aqueduct of Warsaw, Poland. Embedded computers control the simpler nodes, and are directly connected to the SN. Local-PCs (LPCs) control the more complex nodes that consist signal digitizers acquiring data from several detectors. The DAQ in the LPC is split in several processes communicating with sockets in a local sub-network. Each process is dedicated to a very simple task (e.g. data acquisition, data analysis, hydraulics management) in order to have a flexible and fault-tolerant system. The main SN and the local DAQ networks are separated by data routers to ensure the cyber-security.

Ceilometer signal performance with height in high aerosol loads

NASA Astrophysics Data System (ADS)

Bachour, D.; Perez-Astudillo, D.

2016-02-01

This paper is dedicated to the study of the Vaisala CL51 ceilometer backscatter signals during a one-year period, in particular the study of the noise embedded in the signals measured by the ceilometer, under cloudless conditions. The noise analysis is done to provide indication about the maximum atmospheric height up to which the ceilometer signal is still reliable enough in clear-sky conditions, for the detection of changing aerosol contents. The experiment was carried out in Doha, Qatar, for a period of 12 months, from December 2012 to November 2013. 214 clear days were selected during this year. Several tests were performed in order to assess the variability of the backscatter signals from day to day and between different heights in the atmosphere. To the authors' knowledge, it is the first time that the signal performance of a ceilometer is studied in a highly aerosol-loaded region, and for a relatively extended period of time. Considering the whole year, it is found that a height of 5 or 6 km represents a good compromise between including the signals arising from the dynamicity of the atmosphere and removing as much as possible the signal dominated by noise at higher heights. In winter months, however, this limit can be extended up to a height of 7 km.

Thousand-fold fluorescent signal amplification for mHealth diagnostics

PubMed Central

Balsam, Joshua; Rasooly, Reuven; Bruck, Hugh Alan; Rasooly, Avraham

2013-01-01

The low sensitivity of Mobile Health (mHealth) optical detectors, such as those found on mobile phones, is a limiting factor for many mHealth clinical applications. To improve sensitivity, we have combined two approaches for optical signal amplification: (1) a computational approach based on an image stacking algorithm to decrease the image noise and enhance weak signals, and (2) an optical signal amplifier utilizing a capillary tube array. These approaches were used in a detection system which includes a multi-wavelength LEDs capable of exciting many fluorophores in multiple wavelengths, a mobile phone or a webcam as a detector, and capillary tube array configured with 36 capillary tubes for signal enhancement. The capillary array enables a ~100X increase in signal sensitivity for fluorescein, reducing the limit of detection (LOD) for mobile phones and webcams from 1000 nM to 10 nM. Computational image stacking enables another ~10X increase in signal sensitivity, further reducing the LOD for webcam from 10 nM to 1 nM. To demonstrate the feasibility of the device for the detection of disease-related biomarkers, Adenovirus DNA labeled with SYBR Green or fluorescein was analyzed by both our capillary array and a commercial plate reader. The LOD for the capillary array was 5ug/mL, and that of the plate reader was 1 ug/mL. Similar results were obtained using DNA stained with fluorescein. The combination of the two signal amplification approaches enables a ~1000X increase in LOD for the webcam platform. This brings it into the range of a conventional plate reader while using a smaller sample volume (10ul) than the plate reader requires (100 ul). This suggests that such a device could be suitable for biosensing applications where up to 10 fold smaller sample sizes are needed. The simple optical configuration for mHealth described in this paper employing the combined capillary and image processing signal amplification is capable of measuring weak fluorescent signals without the need of dedicated laboratories. It has the potential to be used to increase sensitivity of other optically based mHealth technologies, and may increase mHealth’s clinical utility, especially for telemedicine and for resource-poor settings and global health applications. PMID:23928092

Thousand-fold fluorescent signal amplification for mHealth diagnostics.

PubMed

Balsam, Joshua; Rasooly, Reuven; Bruck, Hugh Alan; Rasooly, Avraham

2014-01-15

The low sensitivity of Mobile Health (mHealth) optical detectors, such as those found on mobile phones, is a limiting factor for many mHealth clinical applications. To improve sensitivity, we have combined two approaches for optical signal amplification: (1) a computational approach based on an image stacking algorithm to decrease the image noise and enhance weak signals, and (2) an optical signal amplifier utilizing a capillary tube array. These approaches were used in a detection system which includes multi-wavelength LEDs capable of exciting many fluorophores in multiple wavelengths, a mobile phone or a webcam as a detector, and capillary tube array configured with 36 capillary tubes for signal enhancement. The capillary array enables a ~100× increase in signal sensitivity for fluorescein, reducing the limit of detection (LOD) for mobile phones and webcams from 1000 nM to 10nM. Computational image stacking enables another ~10× increase in signal sensitivity, further reducing the LOD for webcam from 10nM to 1 nM. To demonstrate the feasibility of the device for the detection of disease-related biomarkers, adenovirus DNA labeled with SYBR green or fluorescein was analyzed by both our capillary array and a commercial plate reader. The LOD for the capillary array was 5 ug/mL, and that of the plate reader was 1 ug/mL. Similar results were obtained using DNA stained with fluorescein. The combination of the two signal amplification approaches enables a ~1000× increase in LOD for the webcam platform. This brings it into the range of a conventional plate reader while using a smaller sample volume (10 ul) than the plate reader requires (100 ul). This suggests that such a device could be suitable for biosensing applications where up to 10 fold smaller sample sizes are needed. The simple optical configuration for mHealth described in this paper employing the combined capillary and image processing signal amplification is capable of measuring weak fluorescent signals without the need of dedicated laboratories. It has the potential to be used to increase sensitivity of other optically based mHealth technologies, and may increase mHealth's clinical utility, especially for telemedicine and for resource-poor settings and global health applications. Published by Elsevier B.V.

Modeling and Design of GaN High Electron Mobility Transistors and Hot Electron Transistors through Monte Carlo Particle-based Device Simulations

NASA Astrophysics Data System (ADS)

Soligo, Riccardo

In this work, the insight provided by our sophisticated Full Band Monte Carlo simulator is used to analyze the behavior of state-of-art devices like GaN High Electron Mobility Transistors and Hot Electron Transistors. Chapter 1 is dedicated to the description of the simulation tool used to obtain the results shown in this work. Moreover, a separate section is dedicated the set up of a procedure to validate to the tunneling algorithm recently implemented in the simulator. Chapter 2 introduces High Electron Mobility Transistors (HEMTs), state-of-art devices characterized by highly non linear transport phenomena that require the use of advanced simulation methods. The techniques for device modeling are described applied to a recent GaN-HEMT, and they are validated with experimental measurements. The main techniques characterization techniques are also described, including the original contribution provided by this work. Chapter 3 focuses on a popular technique to enhance HEMTs performance: the down-scaling of the device dimensions. In particular, this chapter is dedicated to lateral scaling and the calculation of a limiting cutoff frequency for a device of vanishing length. Finally, Chapter 4 and Chapter 5 describe the modeling of Hot Electron Transistors (HETs). The simulation approach is validated by matching the current characteristics with the experimental one before variations of the layouts are proposed to increase the current gain to values suitable for amplification. The frequency response of these layouts is calculated, and modeled by a small signal circuit. For this purpose, a method to directly calculate the capacitance is developed which provides a graphical picture of the capacitative phenomena that limit the frequency response in devices. In Chapter 5 the properties of the hot electrons are investigated for different injection energies, which are obtained by changing the layout of the emitter barrier. Moreover, the large signal characterization of the HET is shown for different layouts, where the collector barrier was scaled.

Development of a dedicated readout ASIC for TPC based X-ray polarimeter

NASA Astrophysics Data System (ADS)

Zhang, Hongyan; Deng, Zhi; Li, Hong; Liu, Yinong; Feng, Hua

2016-07-01

X-ray polarimetry with time projection chambers was firstly proposed by JK Black in 2007 and has been greatly developed since then. It measured two dimensional photoelectron tracks with one dimensional strip and the other dimension was estimated by the drift time from the signal waveforms. A readout ASIC, APV25, originally developed for CMS silicon trackers was used and has shown some limitations such as waveform sampling depth. A dedicated ASIC was developed for TPC based X-ray polarimeters in this paper. It integrated 32 channel circuits and each channel consisted of an analog front-end and a waveform sampler based on switched capacitor array. The analog front-end has a charge sensitive preamplifier with a gain of 25 mV/fC, a CR-RC shaper with a peaking time of 25 ns, a baseline holder and a discriminator for self-triggering. The SCA has a buffer latency of 3.2 μs with 64 cells operating at 20 MSPS. The ASIC was fabricated in a 0.18 μm CMOS process. The equivalent noise charge (ENC) of the analog front-end was measured to be 274.8 e+34.6 e/pF. The effective resolution of the SCA was 8.8 bits at sampling rate up to 50 MSPS. The total power consumption was 2.8 mW per channel. The ASIC was also tested with real TPC detectors and two dimensional photoelectron tracks have been successfully acquired. More tests and analysis on the sensitivity to the polarimetry are undergoing and will be presented in this paper.

Predicted MHC peptide binding promiscuity explains MHC class I 'hotspots' of antigen presentation defined by mass spectrometry eluted ligand data.

PubMed

Jappe, Emma Christine; Kringelum, Jens; Trolle, Thomas; Nielsen, Morten

2018-02-15

Peptides that bind to and are presented by MHC class I and class II molecules collectively make up the immunopeptidome. In the context of vaccine development, an understanding of the immunopeptidome is essential, and much effort has been dedicated to its accurate and cost-effective identification. Current state-of-the-art methods mainly comprise in silico tools for predicting MHC binding, which is strongly correlated with peptide immunogenicity. However, only a small proportion of the peptides that bind to MHC molecules are, in fact, immunogenic, and substantial work has been dedicated to uncovering additional determinants of peptide immunogenicity. In this context, and in light of recent advancements in mass spectrometry (MS), the existence of immunological hotspots has been given new life, inciting the hypothesis that hotspots are associated with MHC class I peptide immunogenicity. We here introduce a precise terminology for defining these hotspots and carry out a systematic analysis of MS and in silico predicted hotspots. We find that hotspots defined from MS data are largely captured by peptide binding predictions, enabling their replication in silico. This leads us to conclude that hotspots, to a great degree, are simply a result of promiscuous HLA binding, which disproves the hypothesis that the identification of hotspots provides novel information in the context of immunogenic peptide prediction. Furthermore, our analyses demonstrate that the signal of ligand processing, although present in the MS data, has very low predictive power to discriminate between MS and in silico defined hotspots. © 2018 John Wiley & Sons Ltd.

Multi-faults decoupling on turbo-expander using differential-based ensemble empirical mode decomposition

NASA Astrophysics Data System (ADS)

Li, Hongguang; Li, Ming; Li, Cheng; Li, Fucai; Meng, Guang

2017-09-01

This paper dedicates on the multi-faults decoupling of turbo-expander rotor system using Differential-based Ensemble Empirical Mode Decomposition (DEEMD). DEEMD is an improved version of DEMD to resolve the imperfection of mode mixing. The nonlinear behaviors of the turbo-expander considering temperature gradient with crack, rub-impact and pedestal looseness faults are investigated respectively, so that the baseline for the multi-faults decoupling can be established. DEEMD is then utilized on the vibration signals of the rotor system with coupling faults acquired by numerical simulation, and the results indicate that DEEMD can successfully decouple the coupling faults, which is more efficient than EEMD. DEEMD is also applied on the vibration signal of the misalignment coupling with rub-impact fault obtained during the adjustment of the experimental system. The conclusion shows that DEEMD can decompose the practical multi-faults signal and the industrial prospect of DEEMD is verified as well.

Quark Phase Transition in Compact Objects and Multimessenger Astronomy: Neutrino Signals, Supernovae and Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Sokolov, V. V.; Vlasyuk, V. V.; Petkov, V. B.

2016-06-01

The International Workshop on Quark Phase Transition in Compact Objects and Multimessenger Astronomy: Neutrino Signals, Supernovae and Gamma-Ray Bursts (October, 7-14, 2015) was dedicated to Quantum ChromoDynamics (QCD) Phase Transitions and observational signals of these transitions related to formation of compact astrophysical objects. The aim of this workshop was to bring together researchers working on the problems of behavior of matter under critical conditions achievable in such astrophysical objects as "strange" or "hybrid" stars and in laboratories at heavy-ion collisions to discuss fundamental issues and recent developments. Topics included both observations (radio, optical and X-ray astronomy, gamma ray bursts, gravitational waves, neutrino detection, heavy-ion collisions, etc.) and theory (supernova simulations, proto-neutron and neutron stars, equation of state of dense matter, neutron star cooling, unstable modes, nucleosynthesis, explosive transitions, quark-gluon plasma).

Changing currents: a strategy for understanding and predicting the changing ocean circulation.

PubMed

Bryden, Harry L; Robinson, Carol; Griffiths, Gwyn

2012-12-13

Within the context of UK marine science, we project a strategy for ocean circulation research over the next 20 years. We recommend a focus on three types of research: (i) sustained observations of the varying and evolving ocean circulation, (ii) careful analysis and interpretation of the observed climate changes for comparison with climate model projections, and (iii) the design and execution of focused field experiments to understand ocean processes that are not resolved in coupled climate models so as to be able to embed these processes realistically in the models. Within UK-sustained observations, we emphasize smart, cost-effective design of the observational network to extract maximum information from limited field resources. We encourage the incorporation of new sensors and new energy sources within the operational environment of UK-sustained observational programmes to bridge the gap that normally separates laboratory prototype from operational instrument. For interpreting the climate-change records obtained through a variety of national and international sustained observational programmes, creative and dedicated UK scientists should lead efforts to extract the meaningful signals and patterns of climate change and to interpret them so as to project future changes. For the process studies, individual scientists will need to work together in team environments to combine observational and process modelling results into effective improvements in the coupled climate models that will lead to more accurate climate predictions.

Development, implementation, and characterization of a standalone embedded viscosity measurement system based on the impedance spectroscopy of a vibrating wire sensor

NASA Astrophysics Data System (ADS)

Santos, José; Janeiro, Fernando M.; Ramos, Pedro M.

2015-10-01

This paper presents an embedded liquid viscosity measurement system based on a vibrating wire sensor. Although multiple viscometers based on different working principles are commercially available, there is still a market demand for a dedicated measurement system capable of performing accurate, fast measurements and requiring little or no operator training for simple systems and solution monitoring. The developed embedded system is based on a vibrating wire sensor that works by measuring the impedance response of the sensor, which depends on the viscosity and density of the liquid in which the sensor is immersed. The core of the embedded system is a digital signal processor (DSP) which controls the waveform generation and acquisitions for the measurement of the impedance frequency response. The DSP also processes the acquired waveforms and estimates the liquid viscosity. The user can interact with the measurement system through a keypad and an LCD or through a computer with a USB connection for data logging and processing. The presented system is tested on a set of viscosity standards and the estimated values are compared with the standard manufacturer specified viscosity values. A stability study of the measurement system is also performed.

Drosophila as a genetic and cellular model for studies on axonal growth

PubMed Central

Sánchez-Soriano, Natalia; Tear, Guy; Whitington, Paul; Prokop, Andreas

2007-01-01

One of the most fascinating processes during nervous system development is the establishment of stereotypic neuronal networks. An essential step in this process is the outgrowth and precise navigation (pathfinding) of axons and dendrites towards their synaptic partner cells. This phenomenon was first described more than a century ago and, over the past decades, increasing insights have been gained into the cellular and molecular mechanisms regulating neuronal growth and navigation. Progress in this area has been greatly assisted by the use of simple and genetically tractable invertebrate model systems, such as the fruit fly Drosophila melanogaster. This review is dedicated to Drosophila as a genetic and cellular model to study axonal growth and demonstrates how it can and has been used for this research. We describe the various cellular systems of Drosophila used for such studies, insights into axonal growth cones and their cytoskeletal dynamics, and summarise identified molecular signalling pathways required for growth cone navigation, with particular focus on pathfinding decisions in the ventral nerve cord of Drosophila embryos. These Drosophila-specific aspects are viewed in the general context of our current knowledge about neuronal growth. PMID:17475018

Tracking of cell nuclei for assessment of in vitro uptake kinetics in ultrasound-mediated drug delivery using fibered confocal fluorescence microscopy.

PubMed

Derieppe, Marc; de Senneville, Baudouin Denis; Kuijf, Hugo; Moonen, Chrit; Bos, Clemens

2014-10-01

Previously, we demonstrated the feasibility to monitor ultrasound-mediated uptake of a cell-impermeable model drug in real time with fibered confocal fluorescence microscopy. Here, we present a complete post-processing methodology, which corrects for cell displacements, to improve the accuracy of pharmacokinetic parameter estimation. Nucleus detection was performed based on the radial symmetry transform algorithm. Cell tracking used an iterative closest point approach. Pharmacokinetic parameters were calculated by fitting a two-compartment model to the time-intensity curves of individual cells. Cells were tracked successfully, improving time-intensity curve accuracy and pharmacokinetic parameter estimation. With tracking, 93 % of the 370 nuclei showed a fluorescence signal variation that was well-described by a two-compartment model. In addition, parameter distributions were narrower, thus increasing precision. Dedicated image analysis was implemented and enabled studying ultrasound-mediated model drug uptake kinetics in hundreds of cells per experiment, using fiber-based confocal fluorescence microscopy.

A user-friendly LabVIEW software platform for grating based X-ray phase-contrast imaging.

PubMed

Wang, Shenghao; Han, Huajie; Gao, Kun; Wang, Zhili; Zhang, Can; Yang, Meng; Wu, Zhao; Wu, Ziyu

2015-01-01

X-ray phase-contrast imaging can provide greatly improved contrast over conventional absorption-based imaging for weakly absorbing samples, such as biological soft tissues and fibre composites. In this study, we introduced an easy and fast way to develop a user-friendly software platform dedicated to the new grating-based X-ray phase-contrast imaging setup at the National Synchrotron Radiation Laboratory of the University of Science and Technology of China. The control of 21 motorized stages, of a piezoelectric stage and of an X-ray tube are achieved with this software, it also covers image acquisition with a flat panel detector for automatic phase stepping scan. Moreover, a data post-processing module for signals retrieval and other custom features are in principle available. With a seamless integration of all the necessary functions in one software package, this platform greatly facilitate users' activities during experimental runs with this grating based X-ray phase contrast imaging setup.

Probing interval timing with scalp-recorded electroencephalography (EEG).

PubMed

Ng, Kwun Kei; Penney, Trevor B

2014-01-01

Humans, and other animals, are able to easily learn the durations of events and the temporal relationships among them in spite of the absence of a dedicated sensory organ for time. This chapter summarizes the investigation of timing and time perception using scalp-recorded electroencephalography (EEG), a non-invasive technique that measures brain electrical potentials on a millisecond time scale. Over the past several decades, much has been learned about interval timing through the examination of the characteristic features of averaged EEG signals (i.e., event-related potentials, ERPs) elicited in timing paradigms. For example, the mismatch negativity (MMN) and omission potential (OP) have been used to study implicit and explicit timing, respectively, the P300 has been used to investigate temporal memory updating, and the contingent negative variation (CNV) has been used as an index of temporal decision making. In sum, EEG measures provide biomarkers of temporal processing that allow researchers to probe the cognitive and neural substrates underlying time perception.

Generalized ISAR--part II: interferometric techniques for three-dimensional location of scatterers.

PubMed

Given, James A; Schmidt, William R

2005-11-01

This paper is the second part of a study dedicated to optimizing diagnostic inverse synthetic aperture radar (ISAR) studies of large naval vessels. The method developed here provides accurate determination of the position of important radio-frequency scatterers by combining accurate knowledge of ship position and orientation with specialized signal processing. The method allows for the simultaneous presence of substantial Doppler returns from both change of roll angle and change of aspect angle by introducing generalized ISAR ates. The first paper provides two modes of interpreting ISAR plots, one valid when roll Doppler is dominant, the other valid when the aspect angle Doppler is dominant. Here, we provide, for each type of ISAR plot technique, a corresponding interferometric ISAR (InSAR) technique. The former, aspect-angle dominated InSAR, is a generalization of standard InSAR; the latter, roll-angle dominated InSAR, seems to be new to this work. Both methods are shown to be efficient at identifying localized scatterers under simulation conditions.

Millie Hughes-Fulford, Scientist and Prior Astronaut

NASA Image and Video Library

2014-03-13

CAPE CANAVERAL, Fla. - T-cell science team member Miya Yoshida, of the Hughes-Fulford Laboratory in San Francisco, Calif., works in a biosafety hood during preflight experiment preparations in the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The immunology experiment will launch on SpaceX-3 and focus on the effects of microgravity on early T-cell signaling pathways. Current work aims to identify and compare the gene expression of microRNAs miRNAs during T-cell activation under normal gravity and in microgravity, and compare those patterns to changes seen in aging populations. The experiment will be the first flown on SpaceX funded by the National Institutes of Health. Dr. Hughes-Fulford flew aboard space shuttle mission STS-40 in June 1991, the first Spacelab mission dedicated to biomedical studies. For more information on the T-cell experiment, visit http://hughesfulfordlab.com and http://www.nasa.gov/ames/research/space-biosciences/t-cell-activation-in-aging-spacex-3/. Photo credit: NASA/Cory Huston

Millie Hughes-Fulford, Scientist and Prior Astronaut

NASA Image and Video Library

2014-03-13

CAPE CANAVERAL, Fla. - Researcher and principal investigator Dr. Millie Hughes-Fulford, of the Hughes-Fulford Laboratory, San Francisco, Calif., at the microscope, examines T-cells as part of preflight experiment operations in the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The immunology experiment will launch on SpaceX-3 and focus on the effects of microgravity on early T-cell signaling pathways. Current work aims to identify and compare the gene expression of microRNAs miRNAs during T-cell activation under normal gravity and in microgravity, and compare those patterns to changes seen in aging populations. The experiment will be the first flown on SpaceX funded by the National Institutes of Health. Dr. Hughes-Fulford flew aboard space shuttle mission STS-40 in June 1991, the first Spacelab mission dedicated to biomedical studies. For more information on the T-cell experiment, visit http://hughesfulfordlab.com and http://www.nasa.gov/ames/research/space-biosciences/t-cell-activation-in-aging-spacex-3/. Photo credit: NASA/Cory Huston

Acoustic sensors in the helmet detect voice and physiology

NASA Astrophysics Data System (ADS)

Scanlon, Michael V.

2003-09-01

The Army Research Laboratory has developed body-contacting acoustic sensors that detect diverse physiological sounds such as heartbeats and breaths, high quality speech, and activity. These sensors use an acoustic impedance-matching gel contained in a soft, compliant pad to enhance the body borne sounds, yet significantly repel airborne noises due to an acoustic impedance mismatch. The signals from such a sensor can be used as a microphone with embedded physiology, or a dedicated digital signal processor can process packetized data to separate physiological parameters from voice, and log parameter trends for performance surveillance. Acoustic sensors were placed inside soldier helmets to monitor voice, physiology, activity, and situational awareness clues such as bullet shockwaves from sniper activity and explosions. The sensors were also incorporated into firefighter breathing masks, neck and wrist straps, and other protective equipment. Heart rate, breath rate, blood pressure, voice and activity can be derived from these sensors (reports at www.arl.army.mil/acoustics). Having numerous sensors at various locations provides a means for array processing to reduce motion artifacts, calculate pulse transit time for passive blood pressure measurement, and the origin of blunt/penetrating traumas such as ballistic wounding. These types of sensors give us the ability to monitor soldiers and civilian emergency first-responders in demanding environments, and provide vital signs information to assess their health status and how that person is interacting with the environment and mission at hand. The Objective Force Warrior, Scorpion, Land Warrior, Warrior Medic, and other military and civilian programs can potentially benefit from these sensors.

Readout and DAQ for Pixel Detectors

NASA Astrophysics Data System (ADS)

Platkevic, Michal

2010-01-01

Data readout and acquisition control of pixel detectors demand the transfer of significantly a large amounts of bits between the detector and the computer. For this purpose dedicated interfaces are used which are designed with focus on features like speed, small dimensions or flexibility of use such as digital signal processors, field-programmable gate arrays (FPGA) and USB communication ports. This work summarizes the readout and DAQ system built for state-of-the-art pixel detectors of the Medipix family.

Is the body-coil at 3 Tesla feasible for the MRI evaluation of the painful knee? A comparative study.

PubMed

Lutterbey, G; Behrends, K; Falkenhausen, M V; Wattjes, M P; Morakkabati, N; Gieseke, J; Schild, H

2007-02-01

The purpose of this study was to compare the in-built body coil of the 3.0-Tesla (T) scanner with a dedicated surface coil of a 1.5 T system regarding knee imaging. We performed an intraindividual prospective clinical trial on 17 patients with knee pain using magnetic resonance imaging (MRI) at 1.5 and 3.0 T systems equipped with identical gradient systems. Proton-density-weighted turbo spin echo sequences with the same spatial resolution and comparable contrast parameters were used. A quantitative measurement of signal to noise ratio (SNR), relative contrast (RC) and contrast to noise ratio (CNR) between muscle and bone marrow was performed, followed by a qualitative assessment of anatomic/pathologic structures and the extent of artefacts. At 3.0 T, 30 lesions (91%) compared to 33 lesions at 1.5 T were detected. The SNR/CNR/RC were moderately reduced at 3.0 T versus 1.5 T (muscle 42 vs 47 and bone 83 vs 112/46 vs 69/0.33 vs 0.43). Motion artefacts from the pulsating popliteal artery were significantly increased at 3.0 T. A visible and measurable signal loss occurred at 3.0 T using the built-in body coil compared with the dedicated 1.5 T knee coil, but nearly all clinically important information could be obtained.

Dedicated cardiac rehabilitation wearable sensor and its clinical potential.

PubMed

Lee, Hooseok; Chung, Heewon; Ko, Hoon; Jeong, Changwon; Noh, Se-Eung; Kim, Chul; Lee, Jinseok

2017-01-01

We describe a wearable sensor developed for cardiac rehabilitation (CR) exercise. To effectively guide CR exercise, the dedicated CR wearable sensor (DCRW) automatically recommends the exercise intensity to the patient by comparing heart rate (HR) measured in real time with a predefined target heart rate zone (THZ) during exercise. The CR exercise includes three periods: pre-exercise, exercise with intensity guidance, and post-exercise. In the pre-exercise period, information such as THZ, exercise type, exercise stage order, and duration of each stage are set up through a smartphone application we developed for iPhones and Android devices. The set-up information is transmitted to the DCRW via Bluetooth communication. In the period of exercise with intensity guidance, the DCRW continuously estimates HR using a reflected pulse signal in the wrist. To achieve accurate HR measurements, we used multichannel photo sensors and increased the chances of acquiring a clean signal. Subsequently, we used singular value decomposition (SVD) for de-noising. For the median and variance of RMSEs in the measured HRs, our proposed method with DCRW provided lower values than those from a single channel-based method and template-based multiple-channel method for the entire exercise stage. In the post-exercise period, the DCRW transmits all the measured HR data to the smartphone application via Bluetooth communication, and the patient can monitor his/her own exercise history.

Investigation of x-ray spectra for iodinated contrast-enhanced dedicated breast CT

PubMed Central

Glick, Stephen J.; Makeev, Andrey

2017-01-01

Abstract. Screening for breast cancer with mammography has been very successful, resulting in part to a reduction of breast cancer mortality by approximately 39% since 1990. However, mammography still has limitations in performance, especially for women with dense breast tissue. Iodinated contrast-enhanced, dedicated breast CT (BCT) has been proposed to improve lesion analysis and the accuracy of diagnostic workup for patients suspected of having breast cancer. A mathematical analysis to explore the use of various x-ray filters for iodinated contrast-enhanced BCT is presented. To assess task-based performance, the ideal linear observer signal-to-noise ratio (SNR) is used as a figure-of-merit under the assumptions of a linear, shift-invariant imaging system. To estimate signal and noise propagation through the BCT detector, a parallel-cascade model was used. The lesion model was embedded into a structured background and included a realistic level of iodine uptake. SNR was computed for 84,000 different exposure settings by varying the kV setting, x-ray filter materials and thickness, breast size, and composition and radiation dose. It is shown that some x-ray filter material/thickness combinations can provide up to 75% improvement in the linear ideal observer SNR over a conventionally used x-ray filter for BCT. This improvement in SNR can be traded off for substantial reductions in mean glandular dose. PMID:28149923

FINDING EXTRATERRESTRIAL LIFE USING GROUND-BASED HIGH-DISPERSION SPECTROSCOPY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snellen, I. A. G.; Le Poole, R.; Brogi, M.

2013-02-20

Exoplanet observations promise one day to unveil the presence of extraterrestrial life. Atmospheric compounds in strong chemical disequilibrium would point to large-scale biological activity just as oxygen and methane do in the Earth's atmosphere. The cancellation of both the Terrestrial Planet Finder and Darwin missions means that it is unlikely that a dedicated space telescope to search for biomarker gases in exoplanet atmospheres will be launched within the next 25 years. Here we show that ground-based telescopes provide a strong alternative for finding biomarkers in exoplanet atmospheres through transit observations. Recent results on hot Jupiters show the enormous potential ofmore » high-dispersion spectroscopy to separate the extraterrestrial and telluric signals, making use of the Doppler shift of the planet. The transmission signal of oxygen from an Earth-twin orbiting a small red dwarf star is only a factor of three smaller than that of carbon monoxide recently detected in the hot Jupiter {tau} Booetis b, albeit such a star will be orders of magnitude fainter. We show that if Earth-like planets are common, the planned extremely large telescopes can detect oxygen within a few dozen transits. Ultimately, large arrays of dedicated flux-collector telescopes equipped with high-dispersion spectrographs can provide the large collecting area needed to perform a statistical study of life-bearing planets in the solar neighborhood.« less

Computerized engineering logic for procurement and dedication processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tulay, M.P.

1996-12-31

This paper summarizes the work performed for designing the system and especially for calculating on-line expected performance and gives some significant results. In an attempt to better meet the needs of operations and maintenance organizations, many nuclear utility procurement engineering groups have simplified their procedures, developed on-line tools for performing the specification of replacement items, and developed relational databases containing part-level information necessary to automate the procurement process. Although these improvements have helped to reduce the engineering necessary to properly specify and accept/dedicate items for nuclear safety-related applications, a number of utilities have recognized that additional long-term savings can bemore » realized by integrating a computerized logic to assist technical procurement engineering personnel.« less

Multi-DSP and FPGA based Multi-channel Direct IF/RF Digital receiver for atmospheric radar

NASA Astrophysics Data System (ADS)

Yasodha, Polisetti; Jayaraman, Achuthan; Kamaraj, Pandian; Durga rao, Meka; Thriveni, A.

2016-07-01

Modern phased array radars depend highly on digital signal processing (DSP) to extract the echo signal information and to accomplish reliability along with programmability and flexibility. The advent of ASIC technology has made various digital signal processing steps to be realized in one DSP chip, which can be programmed as per the application and can handle high data rates, to be used in the radar receiver to process the received signal. Further, recent days field programmable gate array (FPGA) chips, which can be re-programmed, also present an opportunity to utilize them to process the radar signal. A multi-channel direct IF/RF digital receiver (MCDRx) is developed at NARL, taking the advantage of high speed ADCs and high performance DSP chips/FPGAs, to be used for atmospheric radars working in HF/VHF bands. Multiple channels facilitate the radar t be operated in multi-receiver modes and also to obtain the wind vector with improved time resolution, without switching the antenna beam. MCDRx has six channels, implemented on a custom built digital board, which is realized using six numbers of ADCs for simultaneous processing of the six input signals, Xilinx vertex5 FPGA and Spartan6 FPGA, and two ADSPTS201 DSP chips, each of which performs one phase of processing. MCDRx unit interfaces with the data storage/display computer via two gigabit ethernet (GbE) links. One of the six channels is used for Doppler beam swinging (DBS) mode and the other five channels are used for multi-receiver mode operations, dedicatedly. Each channel has (i) ADC block, to digitize RF/IF signal, (ii) DDC block for digital down conversion of the digitized signal, (iii) decoding block to decode the phase coded signal, and (iv) coherent integration block for integrating the data preserving phase intact. ADC block consists of Analog devices make AD9467 16-bit ADCs, to digitize the input signal at 80 MSPS. The output of ADC is centered around (80 MHz - input frequency). The digitized data is fed to DDC block, which down converts the data to base-band. The DDC block has NCO, mixer and two chains of Bessel filters (fifth order cascaded integration comb filter, two FIR filters, two half band filters and programmable FIR filters) for in-phase (I) and Quadrature phase (Q) channels. The NCO has 32 bits and is set to match the output frequency of ADC. Further, DDC down samples (decimation) the data and reduces the data rate to 16 MSPS. This data is further decimated and the data rate is reduced down to 4/2/1/0.5/0.25/0.125/0.0625 MSPS for baud lengths 0.25/0.5/1/2/4/8/16 μs respectively. The down sampled data is then fed to decoding block, which performs cross correlation to achieve pulse compression of the binary-phase coded data to obtain better range resolution with maximum possible height coverage. This step improves the signal power by a factor equal to the length of the code. Coherent integration block integrates the decoded data coherently for successive pulses, which improves the signal to noise ratio and reduces the data volume. DDC, decoding and coherent integration blocks are implemented in Xilinx vertex5 FPGA. Till this point, function of all six channels is same for DBS mode and multi-receiver modes. Data from vertex5 FPGA is transferred to PC via GbE-1 interface for multi-modes or to two Analog devices make ADSP-TS201 DSP chips (A and B), via link port for DBS mode. ADSP-TS201 chips perform the normalization, DC removal, windowing, FFT computation and spectral averaging on the data, which is transferred to storage/display PC via GbE-2 interface for real-time data display and data storing. Physical layer of GbE interface is implemented in an external chip (Marvel 88E1111) and MAC layer is implemented internal to vertex5 FPGA. The MCDRx has total 4 GB of DDR2 memory for data storage. Spartan6 FPGA is used for generating timing signals, required for basic operation of the radar and testing of the MCDRx.

Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1.

PubMed

Szatmári, Tünde; Mundt, Filip; Kumar-Singh, Ashish; Möbus, Lena; Ötvös, Rita; Hjerpe, Anders; Dobra, Katalin

2017-12-08

The cell-surface heparan sulfate proteoglycan syndecan-1 is important for tumor cell proliferation, migration, and cell cycle regulation in a broad spectrum of malignancies. Syndecan-1, however, also translocates to the cell nucleus, where it might regulate various molecular functions. We used a fibrosarcoma model to dissect the functions of syndecan-1 related to the nucleus and separate them from functions related to the cell-surface. Nuclear translocation of syndecan-1 hampered the proliferation of fibrosarcoma cells compared to the mutant lacking nuclear localization signal. The growth inhibitory effect of nuclear syndecan-1 was accompanied by significant accumulation of cells in the G0/G1 phase, which indicated a possible G1/S phase arrest. We implemented multiple, unsupervised global transcriptome and proteome profiling approaches and combined them with functional assays to disclose the molecular mechanisms that governed nuclear translocation and its related functions. We identified genes and pathways related to the nuclear compartment with network enrichment analysis of the transcriptome and proteome. The TGF-β pathway was activated by nuclear syndecan-1, and three genes were significantly altered with the deletion of nuclear localization signal: EGR-1 (early growth response 1), NEK11 (never-in-mitosis gene a-related kinase 11), and DOCK8 (dedicator of cytokinesis 8). These candidate genes were coupled to growth and cell-cycle regulation. Nuclear translocation of syndecan-1 influenced the activity of several other transcription factors, including E2F, NFκβ, and OCT-1. The transcripts and proteins affected by syndecan-1 showed a striking overlap in their corresponding biological processes. These processes were dominated by protein phosphorylation and post-translation modifications, indicative of alterations in intracellular signaling. In addition, we identified molecules involved in the known functions of syndecan-1, including extracellular matrix organization and transmembrane transport. Collectively, abrogation of nuclear translocation of syndecan-1 resulted in a set of changes clustering in distinct patterns, which highlighted the functional importance of nuclear syndecan-1 in hampering cell proliferation and the cell cycle. This study emphasizes the importance of the localization of syndecan-1 when considering its effects on tumor cell fate.

Implementation of a custom time-domain firmware trigger for RADAR-based cosmic ray detection

NASA Astrophysics Data System (ADS)

Prohira, S.; Besson, D.; Kunwar, S.; Ratzlaff, K.; Young, R.

2018-05-01

Interest in Radio-based detection schemes for ultra-high energy cosmic rays (UHECR) has surged in recent years, owing to the potentially very low cost/detection ratio. The method of radio-frequency (RF) scatter has been proposed as potentially the most economical detection technology. Though the first dedicated experiment to employ this method, the Telescope Array RADAR experiment (TARA) reported no signal, efforts to develop more robust and sensitive trigger techniques continue. This paper details the development of a time-domain firmware trigger that exploits characteristics of the expected scattered signal from an UHECR extensive-air shower (EAS). The improved sensitivity of this trigger is discussed, as well as implementation in two separate field deployments from 2016 to 2017.

ObsPy: A Python Toolbox for Seismology - Recent Developments and Applications

NASA Astrophysics Data System (ADS)

Megies, T.; Krischer, L.; Barsch, R.; Sales de Andrade, E.; Beyreuther, M.

2014-12-01

ObsPy (http://www.obspy.org) is a community-driven, open-source project dedicated to building a bridge for seismology into the scientific Python ecosystem. It offersa) read and write support for essentially all commonly used waveform, station, and event metadata file formats with a unified interface,b) a comprehensive signal processing toolbox tuned to the needs of seismologists,c) integrated access to all large data centers, web services and databases, andd) convenient wrappers to legacy codes like libtau and evalresp.Python, currently the most popular language for teaching introductory computer science courses at top-ranked U.S. departments, is a full-blown programming language with the flexibility of an interactive scripting language. Its extensive standard library and large variety of freely available high quality scientific modules cover most needs in developing scientific processing workflows. Together with packages like NumPy, SciPy, Matplotlib, IPython, Pandas, lxml, and PyQt, ObsPy enables the construction of complete workflows in Python. These vary from reading locally stored data or requesting data from one or more different data centers through to signal analysis and data processing and on to visualizations in GUI and web applications, output of modified/derived data and the creation of publication-quality figures.ObsPy enjoys a large world-wide rate of adoption in the community. Applications successfully using it include time-dependent and rotational seismology, big data processing, event relocations, and synthetic studies about attenuation kernels and full-waveform inversions to name a few examples. All functionality is extensively documented and the ObsPy tutorial and gallery give a good impression of the wide range of possible use cases.We will present the basic features of ObsPy, new developments and applications, and a roadmap for the near future and discuss the sustainability of our open-source development model.

Bioinspired integrated nanosystems based on solid-state nanopores: “iontronic” transduction of biological, chemical and physical stimuli

PubMed Central

Pérez-Mitta, Gonzalo; Albesa, Alberto G.; Trautmann, Christina; Toimil-Molares, María Eugenia

2017-01-01

The ability of living systems to respond to stimuli and process information has encouraged scientists to develop integrated nanosystems displaying similar functions and capabilities. In this regard, biological pores have been a source of inspiration due to their exquisite control over the transport of ions within cells, a feature that ultimately plays a major role in multiple physiological processes, e.g. transduction of physical stimuli into nervous signals. Developing abiotic nanopores, which respond to certain chemical, biological or physical inputs producing “iontronic” signals, is now a reality thanks to the combination of “soft” surface science with nanofabrication techniques. The interplay between the functional richness of predesigned molecular components and the remarkable physical characteristics of nanopores plays a critical role in the rational integration of molecular functions into nanopore environments, permitting us to envisage nanopore-based biomimetic integrated nanosystems that respond to a variety of external stimuli such as pH, redox potential, molecule concentration, temperature, or light. Transduction of these stimuli into a predefined “iontronic” response can be amplified by exploiting nanoconfinement and physico-chemical effects such as charge distribution, steric constraints, equilibria displacement, or local changes in ionic concentration, to name but a few examples. While in past decades the focus has been mostly on their fundamental aspects and the in-depth study of their interesting transport properties, for several years now nanopore research has started to shift towards specific practical applications. This work is dedicated to bringing together the latest developments in the use of nanopores as “iontronic” transducing elements. Our aim is to show the wide potential of abiotic nanopores in sensing and signal transduction and also to promote the potential of this technology among doctoral students, postdocs, and researchers. We believe that even a casual reader of this perspective will not fail to be impressed by the wealth of opportunities that solid-state nanopores can offer to the transduction of biological, physical and chemical stimuli. PMID:28572900

Active laser radar (lidar) for measurement of corresponding height and reflectance images

NASA Astrophysics Data System (ADS)

Froehlich, Christoph; Mettenleiter, M.; Haertl, F.

1997-08-01

For the survey and inspection of environmental objects, a non-tactile, robust and precise imaging of height and depth is the basis sensor technology. For visual inspection,surface classification, and documentation purposes, however, additional information concerning reflectance of measured objects is necessary. High-speed acquisition of both geometric and visual information is achieved by means of an active laser radar, supporting consistent 3D height and 2D reflectance images. The laser radar is an optical-wavelength system, and is comparable to devices built by ERIM, Odetics, and Perceptron, measuring the range between sensor and target surfaces as well as the reflectance of the target surface, which corresponds to the magnitude of the back scattered laser energy. In contrast to these range sensing devices, the laser radar under consideration is designed for high speed and precise operation in both indoor and outdoor environments, emitting a minimum of near-IR laser energy. It integrates a laser range measurement system and a mechanical deflection system for 3D environmental measurements. This paper reports on design details of the laser radar for surface inspection tasks. It outlines the performance requirements and introduces the measurement principle. The hardware design, including the main modules, such as the laser head, the high frequency unit, the laser beam deflection system, and the digital signal processing unit are discussed.the signal processing unit consists of dedicated signal processors for real-time sensor data preprocessing as well as a sensor computer for high-level image analysis and feature extraction. The paper focuses on performance data of the system, including noise, drift over time, precision, and accuracy with measurements. It discuses the influences of ambient light, surface material of the target, and ambient temperature for range accuracy and range precision. Furthermore, experimental results from inspection of buildings, monuments and industrial environments are presented. The paper concludes by summarizing results achieved in industrial environments and gives a short outlook to future work.

Student and Preceptor Advancement in a Dedicated Education Site: Innovation in Clinical Education for Advanced Practice Nurses.

PubMed

Hall, Katherine C; Diffenderfer, Sandy K; Stidham, April; Mullins, Christine M

2018-04-19

In the 1990s, dedicated education units transformed undergraduate preceptorships, but graduate preceptorships remain static. The dyadic nurse practitioner preceptorship model supports an environment where faculty, students, and preceptors may overlook nuances that affect the teaching-learning process. This article describes an innovative clinical education model, Student and Preceptor Advancement in a Dedicated Education Site, designed to improve preceptorships for advanced practice nurses. The focus is on adaptations made to facilitate use in advanced practice nursing programs.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

The Time-Frequency Signatures of Advanced Seismic Signals Generated by Debris Flows

NASA Astrophysics Data System (ADS)

Chu, C. R.; Huang, C. J.; Lin, C. R.; Wang, C. C.; Kuo, B. Y.; Yin, H. Y.

2014-12-01

The seismic monitoring is expected to reveal the process of debris flow from the initial area to alluvial fan, because other field monitoring techniques, such as the video camera and the ultrasonic sensor, are limited by detection range. For this reason, seismic approaches have been used as the detection system of debris flows over the past few decades. The analysis of the signatures of the seismic signals in time and frequency domain can be used to identify the different phases of debris flow. This study dedicates to investigate the different stages of seismic signals due to debris flow, including the advanced signal, the main front, and the decaying tail. Moreover, the characteristics of the advanced signals forward to the approach of main front were discussed for the warning purpose. This study presents a permanent system, composed by two seismometers, deployed along the bank of Ai-Yu-Zi Creek in Nantou County, which is one of the active streams with debris flow in Taiwan. The three axes seismometer with frequency response of 7 sec - 200 Hz was developed by the Institute of Earth Sciences (IES), Academia Sinica for the purpose to detect debris flow. The original idea of replacing the geophone system with the seismometer technique was for catching the advanced signals propagating from the upper reach of the stream before debris flow arrival because of the high sensitivity. Besides, the low frequency seismic waves could be also early detected because of the low attenuation. However, for avoiding other unnecessary ambient vibrations, the sensitivity of seismometer should be lower than the general seismometer for detecting teleseism. Three debris flows with different mean velocities were detected in 2013 and 2014. The typical triangular shape was obviously demonstrated in time series data and the spectrograms of the seismic signals from three events. The frequency analysis showed that enormous debris flow bearing huge boulders would induce low frequency seismic waves. Owing to the less attenuation of low frequency waves, advanced signals mainly ranged between 2 and 10 Hz were detected in several minutes prior to the arrival of the main surge of a debris flow. As the results, the prior time of the advanced signals could be used not only to extend the warning time, but also to identify the initial location of a developing debris flow.

The regulation of virulence in phytopathogenic Erwinia species: quorum sensing, antibiotics and ecological considerations.

PubMed

Whitehead, Neil A; Byers, Joseph T; Commander, Paul; Corbett, Mark J; Coulthurst, Sarah J; Everson, Lee; Harris, Abigail K P; Pemberton, Clare L; Simpson, Natalie J L; Slater, Holly; Smith, Debra S; Welch, Martin; Williamson, Neil; Salmond, George P C

2002-08-01

Erwinia carotovora is a Gram-negative bacterial phytopathogen that causes soft-rot disease and potato blackleg. The organism is environmentally widespread and exhibits an opportunistic plant pathogenesis. The ability to secrete multiple plant cell wall-degrading enzymes is a key virulence trait and exoenzyme production is responsive to multiple environmental and physiological cues. One important cue is the cell population density of the pathogen. Cell density is monitored via an acylated homoserine lactone (acyl HSL) signalling molecule, which is thought to diffuse between Erwinia cells in a process now commonly known as 'quorum sensing'. This molecule also acts as the chemical communication signal controlling production of a broad-spectrum beta-lactam antibiotic (1-carbapen-2-em-3-carboxylic acid; carbapenem) synthesised in concert with exoenzyme elaboration, possibly for niche defence. In antibiotic production control, quorum sensing acts at the level of transcriptional activation of the antibiotic biosynthetic cluster. This is achieved via a dedicated LuxR-type protein, CarR that is bound to the signalling molecule. The molecular relay connecting acyl HSL production and exoenzyme induction is not clear, despite the identification of a multitude of global regulatory genes, including those of the RsmA/rsmB system, impinging on enzyme synthesis. Quorum sensing control mediated by acyl HSLs is widespread in Gram-negative bacteria and is responsible for the regulation of diverse phenotypes. Although there is still a paucity of meaningful information on acyl HSL availability and in-situ biological function, there is growing evidence that such molecules play significant roles in microbial ecology.

High-fidelity digital recording and playback sphygmomanometry system: device description and proof of concept.

PubMed

Lee, Jongshill; Chee, Youngjoon; Kim, Inyoung; Karpettas, Nikos; Kollias, Anastasios; Atkins, Neil; Stergiou, George S; O'Brien, Eoin

2015-10-01

This study describes the development of a new digital sphygmocorder (DS-II), which allows the digital recording and playback of the Korotkoff sounds, together with cuff pressure waveform, and its performance in a pilot validation study. A condenser microphone and stethoscope head detect Korotkoff sounds and an electronic chip, dedicated to audio-signal processing, is used to record high-quality sounds. Systolic and diastolic blood pressure (SBP/DBP) are determined from the recorded signals with an automatic beat detection algorithm that displays the cuff pressure at each beat on the monitor. Recordings of Korotkoff sounds, with the cuff pressure waveforms, and the simultaneous on-site assessments of SBP/DBP were performed during 100 measurements in 10 individuals. The observers reassessed the recorded signals to verify their accuracy and differences were calculated. The features of the high-fidelity DS-II, the technical specifications and the assessment procedures utilizing the playback software are described. Interobserver absolute differences (mean±SD) in measurements were 0.7±1.1/1.3±1.3 mmHg (SBP/DBP) with a mercury sphygmomanometer and 0.3±0.9/0.8±1.2 mmHg with the DS-II. The absolute DS-II mercury sphygmomanometer differences were 1.3±1.9/1.5±1.3 mmHg (SBP/DBP). The high-fidelity DS-II device presents satisfactory agreement with simultaneous measurements of blood pressure with a mercury sphygmomanometer. The device will be a valuable methodology for validating new blood pressure measurement technologies and devices.

Hunting dark matter gamma-ray lines with the Fermi LAT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vertongen, Gilles; Weniger, Christoph, E-mail: gilles.vertongen@desy.de, E-mail: weniger@mppmu.mpg.de

2011-05-01

Monochromatic photons could be produced in the annihilation or decay of dark matter particles. At high energies, the search for such line features in the cosmic gamma-ray spectrum is essentially background free because plausible astrophysical processes are not expected to produce such a signal. The observation of a gamma-ray line would hence be a 'smoking-gun' signature for dark matter, making the search for such signals particularly attractive. Among the different dark matter models predicting gamma-ray lines, the local supersymmetric extension of the standard model with small R-parity violation and gravitino LSP is of particular interest because it provides a frameworkmore » where primordial nucleosynthesis, gravitino dark matter and thermal leptogenesis are naturally consistent. Using the two-years Fermi LAT data, we present a dedicated search for gamma-ray lines coming from dark matter annihilation or decay in the Galactic halo. Taking into account the full detector response, and using a binned profile likelihood method, we search for significant line features in the energy spectrum of the diffuse flux observed in different regions of the sky. No evidence for a line signal at the 5σ level is found for photon energies between 1 and 300 GeV, and conservative bounds on dark matter decay rates and annihilation cross sections are presented. Implications for gravitino dark matter in presence of small R-parity violation are discussed, as well as the impact of our results on the prospect for seeing long-lived neutralinos or staus at the LHC.« less

Testing of electrical equipment for a commercial grade dedication program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, J.L.; Srinivas, N.

1995-10-01

The availability of qualified safety related replacement parts for use in nuclear power plants has decreased over time. This has caused many nuclear power plants to purchase commercial grade items (CGI) and utilize the commercial grade dedication process to qualify the items for use in nuclear safety related applications. The laboratories of Technical and Engineering Services (the testing facility of Detroit Edison) have been providing testing services for verification of critical characteristics of these items. This paper presents an overview of the experience in testing electrical equipment with an emphasis on fuses.

Commercial grade item (CGI) dedication of generators for nuclear safety related applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Das, R.K.; Hajos, L.G.

1993-03-01

The number of nuclear safety related equipment suppliers and the availability of spare and replacement parts designed specifically for nuclear safety related application are shrinking rapidly. These have made it necessary for utilities to apply commercial grade spare and replacement parts in nuclear safety related applications after implementing proper acceptance and dedication process to verify that such items conform with the requirements of their use in nuclear safety related application. The general guidelines for the commercial grade item (CGI) acceptance and dedication are provided in US Nuclear Regulatory Commission (NRC) Generic Letters and Electric Power Research Institute (EPRI) Report NP-5652,more » Guideline for the Utilization of Commercial Grade Items in Nuclear Safety Related Applications. This paper presents an application of these generic guidelines for procurement, acceptance, and dedication of a commercial grade generator for use as a standby generator at Salem Generating Station Units 1 and 2. The paper identifies the critical characteristics of the generator which once verified, will provide reasonable assurance that the generator will perform its intended safety function. The paper also delineates the method of verification of the critical characteristics through tests and provide acceptance criteria for the test results. The methodology presented in this paper may be used as specific guidelines for reliable and cost effective procurement and dedication of commercial grade generators for use as standby generators at nuclear power plants.« less

The Airborne Field Artillery: From Inception to Combat Operations

DTIC Science & Technology

2004-06-17

equipment they would use. In the afternoon of Stage “A” the battery personnel dedicated their time to “tumbling, calisthenics, trampoline , and the much...trip. The next day they boarded the Ben My Chice and headed for Belfast, Northern Ireland. They arrived on 11 December and were separated--C Battery...of five lights placed to form a “T,” and a Eureka installation at the head of the “T.” The jump signal was to be given when the leader of the group

A readout circuit dedicated for the detection of chemiluminescence using a silicon photomultiplier

NASA Astrophysics Data System (ADS)

Baszczyk, M.; Dorosz, P.; Mik, L.; Kucewicz, W.; Reczynski, W.; Sapor, M.

2018-05-01

A readout circuit dedicated for the detection of the chemiluminescence phenomenon using a silicon photomultiplier (SiPM) is presented. During chemiluminescence, light is generated as a result of chemical reaction. Chemiluminescence is used in many applications within medicine, chemistry, biology and biotechnology, and is one of the most important sensing techniques in biomedical science and clinical medicine. The front-end electronics consist of a preamplifier and a fast shaper—this produces pulses, the peaking time which is 3.6 ns for a single photon and the FWHM is 3.8 ns. The system has been optimised to measure chemiluminescence—it is sensitive at the level of single photons, it generates a low number of overlapping pulses and is accurate. Two methods of signal detection are analysed and compared: the counting of events and amplitude detection. The relationship between the chemiluminescence light intensity and the concentration of the chemical compound (luminol) is linear in the range of the tested concentrations and has strong linearity parameters and low prediction intervals.

Cellular and oscillatory substrates of fear extinction learning.

PubMed

Davis, Patrick; Zaki, Yosif; Maguire, Jamie; Reijmers, Leon G

2017-11-01

The mammalian brain contains dedicated circuits for both the learned expression and suppression of fear. These circuits require precise coordination to facilitate the appropriate expression of fear behavior, but the mechanisms underlying this coordination remain unclear. Using a combination of chemogenetics, activity-based neuronal-ensemble labeling and in vivo electrophysiology, we found that fear extinction learning confers on parvalbumin-expressing (PV) interneurons in the basolateral amygdala (BLA) a dedicated role in the selective suppression of a previously encoded fear memory and BLA fear-encoding neurons. In addition, following extinction learning, PV interneurons enable a competing interaction between a 6-12 Hz oscillation and a fear-associated 3-6 Hz oscillation within the BLA. Loss of this competition increases a 3-6 Hz oscillatory signature, with BLA→medial prefrontal cortex directionality signaling the recurrence of fear expression. The discovery of cellular and oscillatory substrates of fear extinction learning that critically depend on BLA PV interneurons could inform therapies aimed at preventing the pathological recurrence of fear following extinction learning.

Cellular and Oscillatory Substrates of Fear Extinction Learning

PubMed Central

Davis, Patrick; Zaki, Yosif; Maguire, Jamie; Reijmers, Leon G.

2018-01-01

The mammalian brain contains dedicated circuits for both the learned expression and suppression of fear. These circuits require precise coordination to facilitate the appropriate expression of fear behavior, but the mechanisms underlying this coordination remain unclear. Using a novel combination of chemogenetics, activity-based neuronal-ensemble labeling, and in vivo electrophysiology, we found that fear extinction learning confers parvalbumin-expressing (PV) interneurons in the basolateral amygdala (BLA) with a dedicated role in the selective suppression of a previously encoded fear memory and BLA fear-encoding neurons. In addition, following extinction learning, PV interneurons enable a competing interaction between a 6–12 Hz oscillation and a fear-associated 3–6 Hz oscillation within the BLA. Loss of this competition increases a 3–6 Hz oscillatory signature, with BLA→mPFC directionality signaling the recurrence of fear expression. The discovery of cellular and oscillatory substrates of fear extinction learning that critically depend on BLA PV-interneurons could inform therapies aimed at preventing the pathological recurrence of fear following extinction learning. PMID:28967909

36 CFR 292.14 - Introduction.

Code of Federal Regulations, 2014 CFR

2014-07-01

... dedicating or reserving the land so saved to open space. (2) Community development plan. A narrative plan... with exploration, development, mining or processing of mineral resources except prospecting which will...

36 CFR 292.14 - Introduction.

Code of Federal Regulations, 2013 CFR

2013-07-01

... dedicating or reserving the land so saved to open space. (2) Community development plan. A narrative plan... with exploration, development, mining or processing of mineral resources except prospecting which will...

36 CFR 292.14 - Introduction.

Code of Federal Regulations, 2012 CFR

2012-07-01

... dedicating or reserving the land so saved to open space. (2) Community development plan. A narrative plan... with exploration, development, mining or processing of mineral resources except prospecting which will...

36 CFR 292.14 - Introduction.

Code of Federal Regulations, 2011 CFR

2011-07-01

... dedicating or reserving the land so saved to open space. (2) Community development plan. A narrative plan... with exploration, development, mining or processing of mineral resources except prospecting which will...

36 CFR 292.14 - Introduction.

Code of Federal Regulations, 2010 CFR

2010-07-01

... dedicating or reserving the land so saved to open space. (2) Community development plan. A narrative plan... with exploration, development, mining or processing of mineral resources except prospecting which will...

Development of a 32-channel ASIC for an X-ray APD detector onboard the ISS

NASA Astrophysics Data System (ADS)

Arimoto, Makoto; Harita, Shohei; Sugita, Satoshi; Yatsu, Yoichi; Kawai, Nobuyuki; Ikeda, Hirokazu; Tomida, Hiroshi; Isobe, Naoki; Ueno, Shiro; Mihara, Tatehiro; Serino, Motoko; Kohmura, Takayoshi; Sakamoto, Takanori; Yoshida, Atsumasa; Tsunemi, Hiroshi; Hatori, Satoshi; Kume, Kyo; Hasegawa, Takashi

2018-02-01

We report on the design and performance of a mixed-signal application specific integrated circuit (ASIC) dedicated to avalanche photodiodes (APDs) in order to detect hard X-ray emissions in a wide energy band onboard the International Space Station. To realize wide-band detection from 20 keV to 1 MeV, we use Ce:GAGG scintillators, each coupled to an APD, with low-noise front-end electronics capable of achieving a minimum energy detection threshold of 20 keV. The developed ASIC has the ability to read out 32-channel APD signals using 0.35 μm CMOS technology, and an analog amplifier at the input stage is designed to suppress the capacitive noise primarily arising from the large detector capacitance of the APDs. The ASIC achieves a performance of 2099 e- + 1.5 e-/pF at root mean square (RMS) with a wide 300 fC dynamic range. Coupling a reverse-type APD with a Ce:GAGG scintillator, we obtain an energy resolution of 6.7% (FWHM) at 662 keV and a minimum detectable energy of 20 keV at room temperature (20 °C). Furthermore, we examine the radiation tolerance for space applications by using a 90 MeV proton beam, confirming that the ASIC is free of single-event effects and can operate properly without serious degradation in analog and digital processing.

A Fully Integrated Sensor SoC with Digital Calibration Hardware and Wireless Transceiver at 2.4 GHz

PubMed Central

Kim, Dong-Sun; Jang, Sung-Joon; Hwang, Tae-Ho

2013-01-01

A single-chip sensor system-on-a-chip (SoC) that implements radio for 2.4 GHz, complete digital baseband physical layer (PHY), 10-bit sigma-delta analog-to-digital converter and dedicated sensor calibration hardware for industrial sensing systems has been proposed and integrated in a 0.18-μm CMOS technology. The transceiver's building block includes a low-noise amplifier, mixer, channel filter, receiver signal-strength indicator, frequency synthesizer, voltage-controlled oscillator, and power amplifier. In addition, the digital building block consists of offset quadrature phase-shift keying (OQPSK) modulation, demodulation, carrier frequency offset compensation, auto-gain control, digital MAC function, sensor calibration hardware and embedded 8-bit microcontroller. The digital MAC function supports cyclic redundancy check (CRC), inter-symbol timing check, MAC frame control, and automatic retransmission. The embedded sensor signal processing block consists of calibration coefficient calculator, sensing data calibration mapper and sigma-delta analog-to-digital converter with digital decimation filter. The sensitivity of the overall receiver and the error vector magnitude (EVM) of the overall transmitter are −99 dBm and 18.14%, respectively. The proposed calibration scheme has a reduction of errors by about 45.4% compared with the improved progressive polynomial calibration (PPC) method and the maximum current consumption of the SoC is 16 mA. PMID:23698271

Heroin Abuse Results in Shifted RNA Expression to Neurodegenerative Diseases and Attenuation of TNFα Signaling Pathway.

PubMed

Zhu, Mei; Xu, Yu; Wang, Huawei; Shen, Zongwen; Xie, Zhenrong; Chen, Fengrong; Gao, Yunhong; Chen, Xin; Zhang, Ying; Wu, Qiang; Li, Xuejun; Yu, Juehua; Luo, Huayou; Wang, Kunhua

2018-06-18

Repeated administration of heroin results in the induction of physical dependence, which is characterized as a behavioral state of compulsive drug seeking and a high rate of relapse even after periods of abstinence. However, few studies have been dedicated to characterization of the long-term alterations in heroin-dependent patients (HDPs). Herein, we examined the peripheral blood from 810 HDPs versus 500 healthy controls (HCs) according to the inclusion criteria. Compared with the control group, significant decreases of albumin, triglyceride, and total cholesterol levels were identified in HDPs (P < 0.001) versus HCs coupled with an insignificant decrease in BMI. Meanwhile, RNA-sequencing analyses were performed on blood of 16 long-term HDPs and 25 HCs. The results showed that the TNFα signaling pathway and hematopoiesis related genes were inhibited in HDPs. We further compared the transcriptome data to those of SCA2 and posttraumatic stress disorder patients, identified neurodegenerative diseases related genes were commonly up-regulated in coupled with biological processes "vesicle transport", "mitochondria" and "splicing". Genes in the categories of "protein ubiquitination" were down-regulated indicating potential biochemical alterations shared by all three comparative to their controls. In summary, this is a leading study performing a series of through investigations and using delicate approaches. Results from this study would benefit the study of drug addiction overall and link long-term heroin abuse to neurodegenerative diseases.

A method for the automatic reconstruction of fetal cardiac signals from magnetocardiographic recordings

NASA Astrophysics Data System (ADS)

Mantini, D.; Alleva, G.; Comani, S.

2005-10-01

Fetal magnetocardiography (fMCG) allows monitoring the fetal heart function through algorithms able to retrieve the fetal cardiac signal, but no standardized automatic model has become available so far. In this paper, we describe an automatic method that restores the fetal cardiac trace from fMCG recordings by means of a weighted summation of fetal components separated with independent component analysis (ICA) and identified through dedicated algorithms that analyse the frequency content and temporal structure of each source signal. Multichannel fMCG datasets of 66 healthy and 4 arrhythmic fetuses were used to validate the automatic method with respect to a classical procedure requiring the manual classification of fetal components by an expert investigator. ICA was run with input clusters of different dimensions to simulate various MCG systems. Detection rates, true negative and false positive component categorization, QRS amplitude, standard deviation and signal-to-noise ratio of reconstructed fetal signals, and real and per cent QRS differences between paired fetal traces retrieved automatically and manually were calculated to quantify the performances of the automatic method. Its robustness and reliability, particularly evident with the use of large input clusters, might increase the diagnostic role of fMCG during the prenatal period.

Results for diffusion-weighted imaging with a fourth-channel gradient insert.

PubMed

Feldman, Rebecca E; Scholl, Timothy J; Alford, Jamu K; Handler, William B; Harris, Chad T; Chronik, Blaine A

2011-12-01

Diffusion-weighted imaging suffers from motion artifacts and relatively low signal quality due to the long echo times required to permit the diffusion encoding. We investigated the inclusion of a noncylindrical fourth gradient coil, dedicated entirely to diffusion encoding, into the imaging system. Standard three-axis whole body gradients were used during image acquisition, but we designed and constructed an insert coil to perform diffusion encodings. We imaged three phantoms on a 3-T system with a range of diffusion coefficients. Using the insert gradient, we were able to encode b values of greater than 1300 s/mm(2) with an echo time of just 83 ms. Images obtained using the insert gradient had higher signal to noise ratios than those obtained using the whole body gradient: at 500 s/mm(2) there was a 18% improvement in signal to noise ratio, at 1000 s/mm(2) there was a 39% improvement in signal to noise ratio, and at 1350 s/mm(2) there was a 56% improvement in signal to noise ratio. Using the insert gradient, we were capable of doing diffusion encoding at high b values by using relatively short echo times. Copyright © 2011 Wiley Periodicals, Inc.

CD147 regulates cancer migration via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling.

PubMed

Cui, Hong-Yong; Wang, Shi-Jie; Miao, Ji-Yu; Fu, Zhi-Guang; Feng, Fei; Wu, Jiao; Yang, Xiang-Min; Chen, Zhi-Nan; Jiang, Jian-Li

2016-02-02

The acquisition of inappropriate migratory feature is crucial for tumor metastasis. It has been suggested that CD147 and Annexin A2 are involved in regulating tumor cell movement, while the regulatory mechanisms are far from clear. In this study, we demonstrated that CD147 physically interacted with the N-terminal domain of Annexin A2 and decreased Annexin A2 phosphorylation on tyrosine 23. In vitro kinase assay showed that the I domain of CD147 was indispensable for CD147-mediated downregulation of Annexin A2 phosphorylation by Src. Furthermore, we determined that p-Annexin A2 promoted the expression of dedicator of cytokinesis 3 (DOCK3) and DOCK3 blocked β-catenin nuclear translocation, resulting in inhibition of β-catenin signaling. In addition, DOCK3 inhibited lamellipodium dynamics and tumor cell movement. Also, we found that β-catenin signaling increased WAVE2 expression. Therefore, DOCK3 was characterized as a negative regulator of WAVE2 expression via inhibiting β-catenin signaling. Our study provides the first evidence that CD147 promotes tumor cell movement and metastasis via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling axis.

Shared developmental and evolutionary origins for neural basis of vocal–acoustic and pectoral–gestural signaling

PubMed Central

Bass, Andrew H.; Chagnaud, Boris P.

2012-01-01

Acoustic signaling behaviors are widespread among bony vertebrates, which include the majority of living fishes and tetrapods. Developmental studies in sound-producing fishes and tetrapods indicate that central pattern generating networks dedicated to vocalization originate from the same caudal hindbrain rhombomere (rh) 8-spinal compartment. Together, the evidence suggests that vocalization and its morphophysiological basis, including mechanisms of vocal–respiratory coupling that are widespread among tetrapods, are ancestral characters for bony vertebrates. Premotor-motor circuitry for pectoral appendages that function in locomotion and acoustic signaling develops in the same rh8-spinal compartment. Hence, vocal and pectoral phenotypes in fishes share both developmental origins and roles in acoustic communication. These findings lead to the proposal that the coupling of more highly derived vocal and pectoral mechanisms among tetrapods, including those adapted for nonvocal acoustic and gestural signaling, originated in fishes. Comparative studies further show that rh8 premotor populations have distinct neurophysiological properties coding for equally distinct behavioral attributes such as call duration. We conclude that neural network innovations in the spatiotemporal patterning of vocal and pectoral mechanisms of social communication, including forelimb gestural signaling, have their evolutionary origins in the caudal hindbrain of fishes. PMID:22723366

A Wireless Interface for Replacing the Cables in Bridge-Sensor Applications

PubMed Central

Pavlin, Marko; Novak, Franc

2012-01-01

This paper presents a solution in which a wireless interface is employed to replace the cables in bridge-sensor measurement applications. The most noticeable feature of the presented approach is the fact that the wireless interface simply replaces the cables without any additional hardware modification to the existing system. In this approach, the concept of reciprocal topology is employed, where the transmitter side acquires signals with its own transfer function and the receiver side reconstructs them with the transfer function reciprocal to the transmitter transfer function. In this paper the principle of data acquisition and reconstruction is described together with the implementation details of the signal transfer from the sensor to the signal-monitoring equipment. The wireless data communication was investigated and proprietary data-reduction methods were developed. The proposed methods and algorithms were implemented using two different wireless technologies. The performance was evaluated with a dedicated data-acquisition system and finally, the test results were analyzed. The two different sets of results indicated the high level of amplitude and the temporal accuracy of the wirelessly transferred sensor signals. PMID:23112585

An experimental adaptive radar MTI filter

NASA Astrophysics Data System (ADS)

Gong, Y. H.; Cooling, J. E.

The theoretical and practical features of a self-adaptive filter designed to remove clutter noise from a radar signal are described. The hardware employs an 8-bit microprocessor/fast hardware multiplier combination along with analog-digital and digital-analog interfaces. The software here is implemented in assembler language. It is assumed that there is little overlap between the signal and the noise spectra and that the noise power is much greater than that of the signal. It is noted that one of the most important factors to be considered when designing digital filters is the quantization noise. This works to degrade the steady state performance from that of the ideal (infinite word length) filter. The principal limitation of the filter described here is its low sampling rate (1.72 kHz), due mainly to the time spent on the multiplication routines. The methods discussed here, however, are general and can be applied to both traditional and more complex radar MTI systems, provided that the filter sampling frequency is increased. Dedicated VLSI signal processors are seen as holding considerable promise.

Lunar lander conceptual design

NASA Technical Reports Server (NTRS)

Lee, Joo Ahn; Carini, John; Choi, Andrew; Dillman, Robert; Griffin, Sean J.; Hanneman, Susan; Mamplata, Caesar; Stanton, Edward

1989-01-01

A conceptual design is presented of a Lunar Lander, which can be the primary vehicle to transport the equipment necessary to establish a surface lunar base, the crew that will man the base, and the raw materials which the Lunar Station will process. A Lunar Lander will be needed to operate in the regime between the lunar surface and low lunar orbit (LLO), up to 200 km. This lander is intended for the establishment and operation of a manned surface base on the moon and for the support of the Lunar Space Station. The lander will be able to fulfill the requirements of 3 basic missions: A mission dedicated to delivering maximum payload for setting up the initial lunar base; Multiple missions between LLO and lunar surface dedicated to crew rotation; and Multiple missions dedicated to cargo shipments within the regime of lunar surface and LLO. A complete set of structural specifications is given.

A simple hyperbolic model for communication in parallel processing environments

NASA Technical Reports Server (NTRS)

Stoica, Ion; Sultan, Florin; Keyes, David

1994-01-01

We introduce a model for communication costs in parallel processing environments called the 'hyperbolic model,' which generalizes two-parameter dedicated-link models in an analytically simple way. Dedicated interprocessor links parameterized by a latency and a transfer rate that are independent of load are assumed by many existing communication models; such models are unrealistic for workstation networks. The communication system is modeled as a directed communication graph in which terminal nodes represent the application processes that initiate the sending and receiving of the information and in which internal nodes, called communication blocks (CBs), reflect the layered structure of the underlying communication architecture. The direction of graph edges specifies the flow of the information carried through messages. Each CB is characterized by a two-parameter hyperbolic function of the message size that represents the service time needed for processing the message. The parameters are evaluated in the limits of very large and very small messages. Rules are given for reducing a communication graph consisting of many to an equivalent two-parameter form, while maintaining an approximation for the service time that is exact in both large and small limits. The model is validated on a dedicated Ethernet network of workstations by experiments with communication subprograms arising in scientific applications, for which a tight fit of the model predictions with actual measurements of the communication and synchronization time between end processes is demonstrated. The model is then used to evaluate the performance of two simple parallel scientific applications from partial differential equations: domain decomposition and time-parallel multigrid. In an appropriate limit, we also show the compatibility of the hyperbolic model with the recently proposed LogP model.

Parallel and Serial Processes in Visual Search

ERIC Educational Resources Information Center

Thornton, Thomas L.; Gilden, David L.

2007-01-01

A long-standing issue in the study of how people acquire visual information centers around the scheduling and deployment of attentional resources: Is the process serial, or is it parallel? A substantial empirical effort has been dedicated to resolving this issue. However, the results remain largely inconclusive because the methodologies that have…

Signals of New Physics in the Underlying Event

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harnik, Roni; /Stanford U., ITP /SLAC; Wizansky, Tommer

2010-06-11

LHC searches for new physics focus on combinations of hard physics objects. In this work we propose a qualitatively different soft signal for new physics at the LHC - the 'anomalous underlying event'. Every hard LHC event will be accompanied by a soft underlying event due to QCD and pile-up effects. Though it is often used for QCD and monte carlo studies, here we propose the incorporation of an underlying event analysis in some searches for new physics. An excess of anomalous underlying events may be a smoking-gun signal for particular new physics scenarios such as 'quirks' or 'hidden valleys'more » in which large amounts of energy may be emitted by a large multiplicity of soft particles. We discuss possible search strategies for such soft diffuse signals in the tracking system and calorimetry of the LHC experiments. We present a detailed study of the calorimetric signal in a concrete example, a simple quirk model motivated by folded supersymmetry. In these models the production and radiative decay of highly excited quirk bound states leads to an 'antenna pattern' of soft unclustered energy. Using a dedicated simulation of a toy detector and a 'CMB-like' multipole analysis we compare the signal to the expected backgrounds.« less

Investigation of a novel image segmentation method dedicated to forest fire applications

NASA Astrophysics Data System (ADS)

Rudz, S.; Chetehouna, K.; Hafiane, A.; Laurent, H.; Séro-Guillaume, O.

2013-07-01

To face fire it is crucial to understand its behaviour in order to maximize fighting means. To achieve this task, the development of a metrological tool is necessary for estimating both geometrical and physical parameters involved in forest fire modelling. A key parameter is to estimate fire positions accurately. In this paper an image processing tool especially dedicated to an accurate extraction of fire from an image is presented. In this work, the clustering on several colour spaces is investigated and it appears that the blue chrominance Cb from the YCbCr colour space is the most appropriate. As a consequence, a new segmentation algorithm dedicated to forest fire applications has been built using first an optimized k-means clustering in the Cb-channel and then some properties of fire pixels in the RGB colour space. Next, the performance of the proposed method is evaluated using three supervised evaluation criteria and then compared to other existing segmentation algorithms in the literature. Finally a conclusion is drawn, assessing the good behaviour of the developed algorithm. This paper is dedicated to the memory of Dr Olivier Séro-Guillaume (1950-2013), CNRS Research Director.

Optimization of nonlinear, non-Gaussian Bayesian filtering for diagnosis and prognosis of monotonic degradation processes

NASA Astrophysics Data System (ADS)

Corbetta, Matteo; Sbarufatti, Claudio; Giglio, Marco; Todd, Michael D.

2018-05-01

The present work critically analyzes the probabilistic definition of dynamic state-space models subject to Bayesian filters used for monitoring and predicting monotonic degradation processes. The study focuses on the selection of the random process, often called process noise, which is a key perturbation source in the evolution equation of particle filtering. Despite the large number of applications of particle filtering predicting structural degradation, the adequacy of the picked process noise has not been investigated. This paper reviews existing process noise models that are typically embedded in particle filters dedicated to monitoring and predicting structural damage caused by fatigue, which is monotonic in nature. The analysis emphasizes that existing formulations of the process noise can jeopardize the performance of the filter in terms of state estimation and remaining life prediction (i.e., damage prognosis). This paper subsequently proposes an optimal and unbiased process noise model and a list of requirements that the stochastic model must satisfy to guarantee high prognostic performance. These requirements are useful for future and further implementations of particle filtering for monotonic system dynamics. The validity of the new process noise formulation is assessed against experimental fatigue crack growth data from a full-scale aeronautical structure using dedicated performance metrics.

Comparison of electronic health record system functionalities to support the patient recruitment process in clinical trials.

PubMed

Schreiweis, Björn; Trinczek, Benjamin; Köpcke, Felix; Leusch, Thomas; Majeed, Raphael W; Wenk, Joachim; Bergh, Björn; Ohmann, Christian; Röhrig, Rainer; Dugas, Martin; Prokosch, Hans-Ulrich

2014-11-01

Reusing data from electronic health records for clinical and translational research and especially for patient recruitment has been tackled in a broader manner since about a decade. Most projects found in the literature however focus on standalone systems and proprietary implementations at one particular institution often for only one singular trial and no generic evaluation of EHR systems for their applicability to support the patient recruitment process does yet exist. Thus we sought to assess whether the current generation of EHR systems in Germany provides modules/tools, which can readily be applied for IT-supported patient recruitment scenarios. We first analysed the EHR portfolio implemented at German University Hospitals and then selected 5 sites with five different EHR implementations covering all major commercial systems applied in German University Hospitals. Further, major functionalities required for patient recruitment support have been defined and the five sample EHRs and their standard tools have been compared to the major functionalities. In our analysis of the site's hospital information system environments (with four commercial EHR systems and one self-developed system) we found that - even though no dedicated module for patient recruitment has been provided - most EHR products comprise generic tools such as workflow engines, querying capabilities, report generators and direct SQL-based database access which can be applied as query modules, screening lists and notification components for patient recruitment support. A major limitation of all current EHR products however is that they provide no dedicated data structures and functionalities for implementing and maintaining a local trial registry. At the five sites with standard EHR tools the typical functionalities of the patient recruitment process could be mostly implemented. However, no EHR component is yet directly dedicated to support research requirements such as patient recruitment. We recommend for future developments that EHR customers and vendors focus much more on the provision of dedicated patient recruitment modules. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

On the development of a magnetoresistive sensor for blade tip timing and blade tip clearance measurement systems.

PubMed

Tomassini, R; Rossi, G; Brouckaert, J-F

2016-10-01

A simultaneous blade tip timing (BTT) and blade tip clearance (BTC) measurement system enables the determination of turbomachinery blade vibrations and ensures the monitoring of the existing running gaps between the blade tip and the casing. This contactless instrumentation presents several advantages compared to the well-known telemetry system with strain gauges, at the cost of a more complex data processing procedure. The probes used can be optical, capacitive, eddy current as well as microwaves, everyone with its dedicated electronics and many existing different signal processing algorithms. Every company working in this field has developed its own processing method and sensor technology. Hence, repeating the same test with different instrumentations, the answer is often different. Moreover, rarely it is possible to achieve reliability for in-service measurements. Developments are focused on innovative instrumentations and a common standard. This paper focuses on the results achieved using a novel magnetoresistive sensor for simultaneous tip timing and tip clearance measurements. The sensor measurement principle is described. The sensitivity to gap variation is investigated. In terms of measurement of vibrations, experimental investigations were performed at the Air Force Institute of Technology (ITWL, Warsaw, Poland) in a real aeroengine and in the von Karman Institute (VKI) R2 compressor rig. The advantages and limitations of the magnetoresistive probe for turbomachinery testing are highlighted.

On the development of a magnetoresistive sensor for blade tip timing and blade tip clearance measurement systems

NASA Astrophysics Data System (ADS)

Tomassini, R.; Rossi, G.; Brouckaert, J.-F.

2016-10-01

A simultaneous blade tip timing (BTT) and blade tip clearance (BTC) measurement system enables the determination of turbomachinery blade vibrations and ensures the monitoring of the existing running gaps between the blade tip and the casing. This contactless instrumentation presents several advantages compared to the well-known telemetry system with strain gauges, at the cost of a more complex data processing procedure. The probes used can be optical, capacitive, eddy current as well as microwaves, everyone with its dedicated electronics and many existing different signal processing algorithms. Every company working in this field has developed its own processing method and sensor technology. Hence, repeating the same test with different instrumentations, the answer is often different. Moreover, rarely it is possible to achieve reliability for in-service measurements. Developments are focused on innovative instrumentations and a common standard. This paper focuses on the results achieved using a novel magnetoresistive sensor for simultaneous tip timing and tip clearance measurements. The sensor measurement principle is described. The sensitivity to gap variation is investigated. In terms of measurement of vibrations, experimental investigations were performed at the Air Force Institute of Technology (ITWL, Warsaw, Poland) in a real aeroengine and in the von Karman Institute (VKI) R2 compressor rig. The advantages and limitations of the magnetoresistive probe for turbomachinery testing are highlighted.

Virtualized MME Design for IoT Support in 5G Systems

PubMed Central

Andres-Maldonado, Pilar; Ameigeiras, Pablo; Prados-Garzon, Jonathan; Ramos-Munoz, Juan Jose; Lopez-Soler, Juan Manuel

2016-01-01

Cellular systems are recently being considered an option to provide support to the Internet of Things (IoT). To enable this support, the 3rd Generation Partnership Project (3GPP) has introduced new procedures specifically targeted for cellular IoT. With one of these procedures, the transmissions of small and infrequent data packets from/to the devices are encapsulated in signaling messages and sent through the control plane. However, these transmissions from/to a massive number of devices may imply a major increase of the processing load on the control plane entities of the network and in particular on the Mobility Management Entity (MME). In this paper, we propose two designs of an MME based on Network Function Virtualization (NFV) that aim at facilitating the IoT support. The first proposed design partially separates the processing resources dedicated to each traffic class. The second design includes traffic shaping to control the traffic of each class. We consider three classes: Mobile Broadband (MBB), low latency Machine to Machine communications (lM2M) and delay-tolerant M2M communications. Our proposals enable reducing the processing resources and, therefore, the cost. Additionally, results show that the proposed designs lessen the impact between classes, so they ease the compliance of the delay requirements of MBB and lM2M communications. PMID:27556468

TIR-domain-containing adapter-inducing interferon-β (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy.

PubMed

Gentle, Ian E; McHenry, Kevin T; Weber, Arnim; Metz, Arlena; Kretz, Oliver; Porter, Dale; Häcker, Georg

2017-07-01

The formation of amyloid-like protein structures has recently emerged as a feature in signal transduction, particularly in innate immunity. These structures appear to depend on defined domains for their formation but likely also require dedicated ways to terminate signalling. We, here, define the innate immunity protein/Toll-like receptor adaptor TIR-domain-containing adapter-inducing interferon-β (TRIF) as a novel platform of fibril formation and probe signal initiation through TRIF as well as its termination in Toll-like receptor 3 (TLR3)-stimulated melanoma cells. A main signalling pathway triggered by TLR3 caused apoptosis, which was controlled by inhibitor of apoptosis proteins and was dependent on RIPK1 and independent of TNF. Using correlative electron/fluorescence microscopy, we visualised fibrillar structures formed through both Toll/interleukin-1 receptor and RIP homotypic interacting motif regions of TRIF. We provide evidence that these fibrillary structures are active signalling platforms whose activity is terminated by autophagy. TRIF-signalling enhanced autophagy, and fibrillary structures were partly contained within autophagosomes. Inhibition of autophagy increased levels of pro-apoptotic TRIF complexes, leading to the accumulation of active caspase-8 and enhanced apoptosis while stimulation of autophagy reduced TRIF-dependent death. We conclude that pro-death signals through TRIF are regulated by autophagy and propose that pro-apoptotic signalling through TRIF/RIPK1/caspase-8 occurs in fibrillary platforms. © 2017 Federation of European Biochemical Societies.

Automated Micro-Object Detection for Mobile Diagnostics Using Lens-Free Imaging Technology

PubMed Central

Roy, Mohendra; Seo, Dongmin; Oh, Sangwoo; Chae, Yeonghun; Nam, Myung-Hyun; Seo, Sungkyu

2016-01-01

Lens-free imaging technology has been extensively used recently for microparticle and biological cell analysis because of its high throughput, low cost, and simple and compact arrangement. However, this technology still lacks a dedicated and automated detection system. In this paper, we describe a custom-developed automated micro-object detection method for a lens-free imaging system. In our previous work (Roy et al.), we developed a lens-free imaging system using low-cost components. This system was used to generate and capture the diffraction patterns of micro-objects and a global threshold was used to locate the diffraction patterns. In this work we used the same setup to develop an improved automated detection and analysis algorithm based on adaptive threshold and clustering of signals. For this purpose images from the lens-free system were then used to understand the features and characteristics of the diffraction patterns of several types of samples. On the basis of this information, we custom-developed an automated algorithm for the lens-free imaging system. Next, all the lens-free images were processed using this custom-developed automated algorithm. The performance of this approach was evaluated by comparing the counting results with standard optical microscope results. We evaluated the counting results for polystyrene microbeads, red blood cells, HepG2, HeLa, and MCF7 cells lines. The comparison shows good agreement between the systems, with a correlation coefficient of 0.91 and linearity slope of 0.877. We also evaluated the automated size profiles of the microparticle samples. This Wi-Fi-enabled lens-free imaging system, along with the dedicated software, possesses great potential for telemedicine applications in resource-limited settings. PMID:27164146

DarkBit: a GAMBIT module for computing dark matter observables and likelihoods

NASA Astrophysics Data System (ADS)

Bringmann, Torsten; Conrad, Jan; Cornell, Jonathan M.; Dal, Lars A.; Edsjö, Joakim; Farmer, Ben; Kahlhoefer, Felix; Kvellestad, Anders; Putze, Antje; Savage, Christopher; Scott, Pat; Weniger, Christoph; White, Martin; Wild, Sebastian

2017-12-01

We introduce DarkBit, an advanced software code for computing dark matter constraints on various extensions to the Standard Model of particle physics, comprising both new native code and interfaces to external packages. This release includes a dedicated signal yield calculator for gamma-ray observations, which significantly extends current tools by implementing a cascade-decay Monte Carlo, as well as a dedicated likelihood calculator for current and future experiments ( gamLike). This provides a general solution for studying complex particle physics models that predict dark matter annihilation to a multitude of final states. We also supply a direct detection package that models a large range of direct detection experiments ( DDCalc), and that provides the corresponding likelihoods for arbitrary combinations of spin-independent and spin-dependent scattering processes. Finally, we provide custom relic density routines along with interfaces to DarkSUSY, micrOMEGAs, and the neutrino telescope likelihood package nulike. DarkBit is written in the framework of the Global And Modular Beyond the Standard Model Inference Tool ( GAMBIT), providing seamless integration into a comprehensive statistical fitting framework that allows users to explore new models with both particle and astrophysics constraints, and a consistent treatment of systematic uncertainties. In this paper we describe its main functionality, provide a guide to getting started quickly, and show illustrative examples for results obtained with DarkBit (both as a stand-alone tool and as a GAMBIT module). This includes a quantitative comparison between two of the main dark matter codes ( DarkSUSY and micrOMEGAs), and application of DarkBit 's advanced direct and indirect detection routines to a simple effective dark matter model.

Track-monitoring from the dynamic response of an operational train

NASA Astrophysics Data System (ADS)

Lederman, George; Chen, Siheng; Garrett, James; Kovačević, Jelena; Noh, Hae Young; Bielak, Jacobo

2017-03-01

We explore a data-driven approach for monitoring rail infrastructure from the dynamic response of a train in revenue-service. Presently, track inspection is performed either visually or with dedicated track geometry cars. In this study, we examine a more economical approach where track inspection is performed by analyzing vibration data collected from an operational passenger train. The high frequency with which passenger trains travel each section of track means that faults can be detected sooner than with dedicated inspection vehicles, and the large number of passes over each section of track makes a data-driven approach statistically feasible. We have deployed a test-system on a light-rail vehicle and have been collecting data for the past two years. The collected data underscores two of the main challenges that arise in train-based track monitoring: the speed of the train at a given location varies from pass to pass and the position of the train is not known precisely. In this study, we explore which feature representations of the data best characterize the state of the tracks despite these sources of uncertainty (i.e., in the spatial domain or frequency domain), and we examine how consistently change detection approaches can identify track changes from the data. We show the accuracy of these different representations, or features, and different change detection approaches on two types of track changes, track replacement and tamping (a maintenance procedure to improve track geometry), and two types of data, simulated data and operational data from our test-system. The sensing, signal processing, and data analysis we propose in the study could facilitate safer trains and more cost-efficient maintenance in the future. Moreover, the proposed approach is quite general and could be extended to other parts of the infrastructure, including bridges.

Probabilistic simulation of concurrent engineering of propulsion systems

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Singhal, S. N.

1993-01-01

Technology readiness and the available infrastructure is assessed for timely computational simulation of concurrent engineering for propulsion systems. Results for initial coupled multidisciplinary, fabrication-process, and system simulators are presented including uncertainties inherent in various facets of engineering processes. An approach is outlined for computationally formalizing the concurrent engineering process from cradle-to-grave via discipline dedicated workstations linked with a common database.

Dedicated hardware processor and corresponding system-on-chip design for real-time laser speckle imaging.

PubMed

Jiang, Chao; Zhang, Hongyan; Wang, Jia; Wang, Yaru; He, Heng; Liu, Rui; Zhou, Fangyuan; Deng, Jialiang; Li, Pengcheng; Luo, Qingming

2011-11-01

Laser speckle imaging (LSI) is a noninvasive and full-field optical imaging technique which produces two-dimensional blood flow maps of tissues from the raw laser speckle images captured by a CCD camera without scanning. We present a hardware-friendly algorithm for the real-time processing of laser speckle imaging. The algorithm is developed and optimized specifically for LSI processing in the field programmable gate array (FPGA). Based on this algorithm, we designed a dedicated hardware processor for real-time LSI in FPGA. The pipeline processing scheme and parallel computing architecture are introduced into the design of this LSI hardware processor. When the LSI hardware processor is implemented in the FPGA running at the maximum frequency of 130 MHz, up to 85 raw images with the resolution of 640×480 pixels can be processed per second. Meanwhile, we also present a system on chip (SOC) solution for LSI processing by integrating the CCD controller, memory controller, LSI hardware processor, and LCD display controller into a single FPGA chip. This SOC solution also can be used to produce an application specific integrated circuit for LSI processing.

ScanSAR interferometric processing using existing standard InSAR software for measuring large scale land deformation

NASA Astrophysics Data System (ADS)

Liang, Cunren; Zeng, Qiming; Jia, Jianying; Jiao, Jian; Cui, Xi'ai

2013-02-01

Scanning synthetic aperture radar (ScanSAR) mode is an efficient way to map large scale geophysical phenomena at low cost. The work presented in this paper is dedicated to ScanSAR interferometric processing and its implementation by making full use of existing standard interferometric synthetic aperture radar (InSAR) software. We first discuss the properties of the ScanSAR signal and its phase-preserved focusing using the full aperture algorithm in terms of interferometry. Then a complete interferometric processing flow is proposed. The standard ScanSAR product is decoded subswath by subswath with burst gaps padded with zero-pulses, followed by a Doppler centroid frequency estimation for each subswath and a polynomial fit of all of the subswaths for the whole scene. The burst synchronization of the interferometric pair is then calculated, and only the synchronized pulses are kept for further interferometric processing. After the complex conjugate multiplication of the interferometric pair, the residual non-integer pulse repetition interval (PRI) part between adjacent bursts caused by zero padding is compensated by resampling using a sinc kernel. The subswath interferograms are then mosaicked, in which a method is proposed to remove the subswath discontinuities in the overlap area. Then the following interferometric processing goes back to the traditional stripmap processing flow. A processor written with C and Fortran languages and controlled by Perl scripts is developed to implement these algorithms and processing flow based on the JPL/Caltech Repeat Orbit Interferometry PACkage (ROI_PAC). Finally, we use the processor to process ScanSAR data from the Envisat and ALOS satellites and obtain large scale deformation maps in the radar line-of-sight (LOS) direction.

Active thermography and post-processing image enhancement for recovering of abraded and paint-covered alphanumeric identification marks

NASA Astrophysics Data System (ADS)

Montanini, R.; Quattrocchi, A.; Piccolo, S. A.

2016-09-01

Alphanumeric marking is a common technique employed in industrial applications for identification of products. However, the realised mark can undergo deterioration, either by extensive use or voluntary deletion (e.g. removal of identification numbers of weapons or vehicles). For recovery of the lost data many destructive or non-destructive techniques have been endeavoured so far, which however present several restrictions. In this paper, active infrared thermography has been exploited for the first time in order to assess its effectiveness in restoring paint covered and abraded labels made by means of different manufacturing processes (laser, dot peen, impact, cold press and scribe). Optical excitation of the target surface has been achieved using pulse (PT), lock-in (LT) and step heating (SHT) thermography. Raw infrared images were analysed with a dedicated image processing software originally developed in Matlab™, exploiting several methods, which include thermographic signal reconstruction (TSR), guided filtering (GF), block guided filtering (BGF) and logarithmic transformation (LN). Proper image processing of the raw infrared images resulted in superior contrast and enhanced readability. In particular, for deeply abraded marks, good outcomes have been obtained by application of logarithmic transformation to raw PT images and block guided filtering to raw phase LT images. With PT and LT it was relatively easy to recover labels covered by paint, with the latter one providing better thermal contrast for all the examined targets. Step heating thermography never led to adequate label identification instead.

Lessons Learned from LIBS Calibration Development

NASA Astrophysics Data System (ADS)

Dyar, M. D.; Breves, E. A.; Lepore, K. H.; Boucher, T. F.; Giguere, S.

2016-10-01

More than two decades of work have been dedicated to development of robust standards, data processing, and calibration tools for LIBS. Here we summarize major considerations for improving accuracy of LIBS chemical analyses.

[New pharmaceuticals in treatment of chronic dust bronchitis].

PubMed

Kosarev, V V; Vakurova, N V; Babanov, S A

2007-01-01

The study was dedicated to the assessment of the therapeutic possibilities provided by erespal (fenspirid) as a new class of pharmaceuticals inhibiting the inflammatory process, in patients with chronic dust bronchitis.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lecomte, Roger; Arpin, Louis; Beaudoin, Jean-Franç

Purpose: LabPET II is a new generation APD-based PET scanner designed to achieve sub-mm spatial resolution using truly pixelated detectors and highly integrated parallel front-end processing electronics. Methods: The basic element uses a 4×8 array of 1.12×1.12 mm{sup 2} Lu{sub 1.9}Y{sub 0.1}SiO{sub 5}:Ce (LYSO) scintillator pixels with one-to-one coupling to a 4×8 pixelated monolithic APD array mounted on a ceramic carrier. Four detector arrays are mounted on a daughter board carrying two flip-chip, 64-channel, mixed-signal, application-specific integrated circuits (ASIC) on the backside interfacing to two detector arrays each. Fully parallel signal processing was implemented in silico by encoding time andmore » energy information using a dual-threshold Time-over-Threshold (ToT) scheme. The self-contained 128-channel detector module was designed as a generic component for ultra-high resolution PET imaging of small to medium-size animals. Results: Energy and timing performance were optimized by carefully setting ToT thresholds to minimize the noise/slope ratio. ToT spectra clearly show resolved 511 keV photopeak and Compton edge with ToT resolution well below 10%. After correction for nonlinear ToT response, energy resolution is typically 24±2% FWHM. Coincidence time resolution between opposing 128-channel modules is below 4 ns FWHM. Initial imaging results demonstrate that 0.8 mm hot spots of a Derenzo phantom can be resolved. Conclusion: A new generation PET scanner featuring truly pixelated detectors was developed and shown to achieve a spatial resolution approaching the physical limit of PET. Future plans are to integrate a small-bore dedicated mouse version of the scanner within a PET/CT platform.« less

Characterization of the targeting signal in mitochondrial β-barrel proteins

PubMed Central

Jores, Tobias; Klinger, Anna; Groß, Lucia E.; Kawano, Shin; Flinner, Nadine; Duchardt-Ferner, Elke; Wöhnert, Jens; Kalbacher, Hubert; Endo, Toshiya; Schleiff, Enrico; Rapaport, Doron

2016-01-01

Mitochondrial β-barrel proteins are synthesized on cytosolic ribosomes and must be specifically targeted to the organelle before their integration into the mitochondrial outer membrane. The signal that assures such precise targeting and its recognition by the organelle remained obscure. In the present study we show that a specialized β-hairpin motif is this long searched for signal. We demonstrate that a synthetic β-hairpin peptide competes with the import of mitochondrial β-barrel proteins and that proteins harbouring a β-hairpin peptide fused to passenger domains are targeted to mitochondria. Furthermore, a β-hairpin motif from mitochondrial proteins targets chloroplast β-barrel proteins to mitochondria. The mitochondrial targeting depends on the hydrophobicity of the β-hairpin motif. Finally, this motif interacts with the mitochondrial import receptor Tom20. Collectively, we reveal that β-barrel proteins are targeted to mitochondria by a dedicated β-hairpin element, and this motif is recognized at the organelle surface by the outer membrane translocase. PMID:27345737

After the Doors Opened: Asking "Why" at a New Community College

ERIC Educational Resources Information Center

Evenbeck, Scott; Merians, Linda E.

2016-01-01

This chapter describes some of the major principles, practices, and processes involved in designing and founding a new community college dedicated to improving student outcomes by doing things differently.

Sliding versus Deciding in Relationships: Associations with Relationship Quality, Commitment, and Infidelity

PubMed Central

Owen, Jesse; Rhoades, Galena K.; Stanley, Scott M.

2013-01-01

From choosing a partner to date to deciding to cohabit or marry, individuals are faced with many relationship choices. Given the costs of failed relationships (e.g., personal distress, problems with work, lower well-being for children, lost opportunities to meet other partners), it is important consider how individuals are approaching these decisions. The current study tested if more thoughtful and clear relationship decision-making processes would relate to individuals’ levels of satisfaction with and dedication to their partners as well as their extra-dyadic involvements. In a sample of 252 men and women, the results showed that regardless of relationship status (i.e., dating, cohabiting, or married), those who reported more thoughtful decision-making processes also reported more dedication to their partners, higher satisfaction with the relationship, and fewer extra-dyadic involvements. PMID:23690736

Implementation and Testing of VLBI Software Correlation at the USNO

NASA Technical Reports Server (NTRS)

Fey, Alan; Ojha, Roopesh; Boboltz, Dave; Geiger, Nicole; Kingham, Kerry; Hall, David; Gaume, Ralph; Johnston, Ken

2010-01-01

The Washington Correlator (WACO) at the U.S. Naval Observatory (USNO) is a dedicated VLBI processor based on dedicated hardware of ASIC design. The WACO is currently over 10 years old and is nearing the end of its expected lifetime. Plans for implementation and testing of software correlation at the USNO are currently being considered. The VLBI correlation process is, by its very nature, well suited to a parallelized computing environment. Commercial off-the-shelf computer hardware has advanced in processing power to the point where software correlation is now both economically and technologically feasible. The advantages of software correlation are manifold but include flexibility, scalability, and easy adaptability to changing environments and requirements. We discuss our experience with and plans for use of software correlation at USNO with emphasis on the use of the DiFX software correlator.

Variants of Independence in the Perception of Facial Identity and Expression

ERIC Educational Resources Information Center

Fitousi, Daniel; Wenger, Michael J.

2013-01-01

A prominent theory in the face perception literature--the parallel-route hypothesis (Bruce & Young, 1986)--assumes a dedicated channel for the processing of identity that is separate and independent from the channel(s) in which nonidentity information is processed (e.g., expression, eye gaze). The current work subjected this assumption to…

Simultaneous transfer of optical frequency and time over 306 km long-haul optical fibre link

NASA Astrophysics Data System (ADS)

Hucl, Vaclav; Cizek, Martin; Pravdova, Lenka; Rerucha, Simon; Hrabina, Jan; Mikel, Bretislav; Smotlacha, Vladimir; Vojtech, Josef; Lazar, Josef; Cip, Ondrej

2016-12-01

Optical fibre links for distributing optical frequencies and time stamps were researched and experimentally tested in the past fifteen years. They have been used mainly for stability comparison of experimental optical clocks. But recent development puts demands on a technology transfer from laboratory experiments to the real industry. The remote calibration of interrogators of Fibre Bragg Grating strain sensory networks is one of important examples. The first step of the adoption the time and frequency broadcasting should be the drop-out free long-term operation of this technology between research laboratories connected via long-haul fibre links. We present a 306 km long-haul optical fibre link between the cities of Prague and Brno in the Czech Republic where a coherent transfer of stable optical frequency and a stable time signal has been firstly demonstrated. The link between ISI CAS Brno and CESNET Prague uses an internet communication fibre where a window of 1540-1546 nm is dedicated for the coherent transfer and 1PPS signal. The link is equipped with 6 bidirectional EDFA amplifiers. The optical frequency standard based on the highly-coherent laser Koheras Adjustik working at 1540.5 nm and stabilized with a saturation absorption spectroscopy technique was used for the coherent wave transfer. The suppression of the Doppler shift induced by the optical fibre was based on an accoustooptical modulator with a servo-loop including a fast PID controller processing the beat-note frequency given by mixing of the Adjustik laser (Brno) and the reflected frequency of this laser from the far end of 306 km long-haul fibre link (Prague). We verified the Doppler shift suppression for the coherent wave with a measuring method analysing the transport delay of the 1PPS signal.

ALR - Laser altimeter for the ASTER deep space mission. Simulated operation above a surface with crater

NASA Astrophysics Data System (ADS)

de Brum, A. G. V.; da Cruz, F. C.; Hetem, A., Jr.

2015-10-01

To assist in the investigation of the triple asteroid system 2001-SN263, the deep space mission ASTER will carry onboard a laser altimeter. The instrument was named ALR and its development is now in progress. In order to help in the instrument design, with a view to the creation of software to control the instrument, a package of computer programs was produced to simulate the operation of a pulsed laser altimeter with operating principle based on the measurement of the time of flight of the travelling pulse. This software Simulator was called ALR_Sim, and the results obtained with its use represent what should be expected as return signal when laser pulses are fired toward a target, reflect on it and return to be detected by the instrument. The program was successfully tested with regard to some of the most common situations expected. It constitutes now the main workbench dedicated to the creation and testing of control software to embark in the ALR. In addition, the Simulator constitutes also an important tool to assist the creation of software to be used on Earth, in the processing and analysis of the data received from the instrument. This work presents the results obtained in the special case which involves the modeling of a surface with crater, along with the simulation of the instrument operation above this type of terrain. This study points out that the comparison of the wave form obtained as return signal after reflection of the laser pulse on the surface of the crater with the expected return signal in the case of a flat and homogeneous surface is a useful method that can be applied for terrain details extraction.

Maturation of Structural Health Management Systems for Solid Rocket Motors

NASA Technical Reports Server (NTRS)

Quing, Xinlin; Beard, Shawn; Zhang, Chang

2011-01-01

Concepts of an autonomous and automated space-compliant diagnostic system were developed for conditioned-based maintenance (CBM) of rocket motors for space exploration vehicles. The diagnostic system will provide real-time information on the integrity of critical structures on launch vehicles, improve their performance, and greatly increase crew safety while decreasing inspection costs. Using the SMART Layer technology as a basis, detailed procedures and calibration techniques for implementation of the diagnostic system were developed. The diagnostic system is a distributed system, which consists of a sensor network, local data loggers, and a host central processor. The system detects external impact to the structure. The major functions of the system include an estimate of impact location, estimate of impact force at impacted location, and estimate of the structure damage at impacted location. This system consists of a large-area sensor network, dedicated multiple local data loggers with signal processing and data analysis software to allow for real-time, in situ monitoring, and longterm tracking of structural integrity of solid rocket motors. Specifically, the system could provide easy installation of large sensor networks, onboard operation under harsh environments and loading, inspection of inaccessible areas without disassembly, detection of impact events and impact damage in real-time, and monitoring of a large area with local data processing to reduce wiring.

Noise reduction of coincidence detector output by the inferior colliculus of the barn owl.

PubMed

Christianson, G Björn; Peña, José Luis

2006-05-31

A recurring theme in theoretical work is that integration over populations of similarly tuned neurons can reduce neural noise. However, there are relatively few demonstrations of an explicit noise reduction mechanism in a neural network. Here we demonstrate that the brainstem of the barn owl includes a stage of processing apparently devoted to increasing the signal-to-noise ratio in the encoding of the interaural time difference (ITD), one of two primary binaural cues used to compute the position of a sound source in space. In the barn owl, the ITD is processed in a dedicated neural pathway that terminates at the core of the inferior colliculus (ICcc). The actual locus of the computation of the ITD is before ICcc in the nucleus laminaris (NL), and ICcc receives no inputs carrying information that did not originate in NL. Unlike in NL, the rate-ITD functions of ICcc neurons require as little as a single stimulus presentation per ITD to show coherent ITD tuning. ICcc neurons also displayed a greater dynamic range with a maximal difference in ITD response rates approximately double that seen in NL. These results indicate that ICcc neurons perform a computation functionally analogous to averaging across a population of similarly tuned NL neurons.

Novel hyperspectral prediction method and apparatus

NASA Astrophysics Data System (ADS)

Kemeny, Gabor J.; Crothers, Natalie A.; Groth, Gard A.; Speck, Kathy A.; Marbach, Ralf

2009-05-01

Both the power and the challenge of hyperspectral technologies is the very large amount of data produced by spectral cameras. While off-line methodologies allow the collection of gigabytes of data, extended data analysis sessions are required to convert the data into useful information. In contrast, real-time monitoring, such as on-line process control, requires that compression of spectral data and analysis occur at a sustained full camera data rate. Efficient, high-speed practical methods for calibration and prediction are therefore sought to optimize the value of hyperspectral imaging. A novel method of matched filtering known as science based multivariate calibration (SBC) was developed for hyperspectral calibration. Classical (MLR) and inverse (PLS, PCR) methods are combined by spectroscopically measuring the spectral "signal" and by statistically estimating the spectral "noise." The accuracy of the inverse model is thus combined with the easy interpretability of the classical model. The SBC method is optimized for hyperspectral data in the Hyper-CalTM software used for the present work. The prediction algorithms can then be downloaded into a dedicated FPGA based High-Speed Prediction EngineTM module. Spectral pretreatments and calibration coefficients are stored on interchangeable SD memory cards, and predicted compositions are produced on a USB interface at real-time camera output rates. Applications include minerals, pharmaceuticals, food processing and remote sensing.

Fluctuations and differential contraction during regeneration of Hydra vulgaris tissue toroids

NASA Astrophysics Data System (ADS)

Krahe, Michael; Wenzel, Iris; Lin, Kao-Nung; Fischer, Julia; Goldmann, Joseph; Kästner, Markus; Fütterer, Claus

2013-03-01

We studied regenerating bilayered tissue toroids dissected from Hydra vulgaris polyps and relate our macroscopic observations to the dynamics of force-generating mesoscopic cytoskeletal structures. Tissue fragments undergo a specific toroid-spheroid folding process leading to complete regeneration towards a new organism. The time scale of folding is too fast for biochemical signalling or morphogenetic gradients, which forced us to assume purely mechanical self-organization. The initial pattern selection dynamics was studied by embedding toroids into hydro-gels, allowing us to observe the deformation modes over longer periods of time. We found increasing mechanical fluctuations which break the toroidal symmetry, and discuss the evolution of their power spectra for various gel stiffnesses. Our observations are related to single-cell studies which explain the mechanical feasibility of the folding process. In addition, we observed switching of cells from a tissue bound to a migrating state after folding failure as well as in tissue injury. We found a supra-cellular actin ring assembled along the toroid's inner edge. Its contraction can lead to the observed folding dynamics as we could confirm by finite element simulations. This actin ring in the inner cell layer is assembled by myosin-driven length fluctuations of supra-cellular F-actin bundles (myonemes) in the outer cell layer. This paper is dedicated to Malcolm Steinberg.

Neural responses to ambiguity involve domain-general and domain-specific emotion processing systems.

PubMed

Neta, Maital; Kelley, William M; Whalen, Paul J

2013-04-01

Extant research has examined the process of decision making under uncertainty, specifically in situations of ambiguity. However, much of this work has been conducted in the context of semantic and low-level visual processing. An open question is whether ambiguity in social signals (e.g., emotional facial expressions) is processed similarly or whether a unique set of processors come on-line to resolve ambiguity in a social context. Our work has examined ambiguity using surprised facial expressions, as they have predicted both positive and negative outcomes in the past. Specifically, whereas some people tended to interpret surprise as negatively valenced, others tended toward a more positive interpretation. Here, we examined neural responses to social ambiguity using faces (surprise) and nonface emotional scenes (International Affective Picture System). Moreover, we examined whether these effects are specific to ambiguity resolution (i.e., judgments about the ambiguity) or whether similar effects would be demonstrated for incidental judgments (e.g., nonvalence judgments about ambiguously valenced stimuli). We found that a distinct task control (i.e., cingulo-opercular) network was more active when resolving ambiguity. We also found that activity in the ventral amygdala was greater to faces and scenes that were rated explicitly along the dimension of valence, consistent with findings that the ventral amygdala tracks valence. Taken together, there is a complex neural architecture that supports decision making in the presence of ambiguity: (a) a core set of cortical structures engaged for explicit ambiguity processing across stimulus boundaries and (b) other dedicated circuits for biologically relevant learning situations involving faces.

GNSS Spoofing Network Monitoring Based on Differential Pseudorange.

PubMed

Zhang, Zhenjun; Zhan, Xingqun

2016-10-23

Spoofing is becoming a serious threat to various Global Navigation Satellite System (GNSS) applications, especially for those that require high reliability and security such as power grid synchronization and applications related to first responders and aviation safety. Most current works on anti-spoofing focus on spoofing detection from the individual receiver side, which identifies spoofing when it is under an attack. This paper proposes a novel spoofing network monitoring (SNM) mechanism aiming to reveal the presence of spoofing within an area. Consisting of several receivers and one central processing component, it keeps detecting spoofing even when the network is not attacked. The mechanism is based on the different time difference of arrival (TDOA) properties between spoofing and authentic signals. Normally, TDOAs of spoofing signals from a common spoofer are identical while those of authentic signals from diverse directions are dispersed. The TDOA is measured as the differential pseudorange to carrier frequency ratio (DPF). In a spoofing case, the DPFs include those of both authentic and spoofing signals, among which the DPFs of authentic are dispersed while those of spoofing are almost overlapped. An algorithm is proposed to search for the DPFs that are within a pre-defined small range, and an alarm will be raised if several DPFs are found within such range. The proposed SNM methodology is validated by simulations and a partial field trial. Results show 99.99% detection and 0.01% false alarm probabilities are achieved. The SNM has the potential to be adopted in various applications such as (1) alerting dedicated users when spoofing is occurring, which could significantly shorten the receiver side spoofing cost; (2) in combination with GNSS performance monitoring systems, such as the Continuous Operating Reference System (CORS) and GNSS Availability, Accuracy, Reliability anD Integrity Assessment for Timing and Navigation (GAARDIAN) System, to provide more reliable monitoring services.

Dedicated Operating Room Teams and Clinical Outcomes in an Enhanced Recovery after Surgery Pathway for Colorectal Surgery.

PubMed

Grant, Michael C; Hanna, Andrew; Benson, Andrew; Hobson, Deborah; Wu, Christopher L; Yuan, Christina T; Rosen, Michael; Wick, Elizabeth C

2018-03-01

Our aim was to determine whether the establishment of a dedicated operating room team leads to improved process measure compliance and clinical outcomes in an Enhanced Recovery after Surgery (ERAS) program. Enhanced Recovery after Surgery programs involve the application of bundled best practices to improve the value of perioperative care. Successful implementation and sustainment of ERAS programs has been linked to compliance with protocol elements. Development of dedicated teams of anesthesia providers was a component of ERAS implementation. Intraoperative provider team networks (surgeons, anesthesiologists, and certified registered nurse anesthetists) were developed for all cases before and after implementation of colorectal ERAS. Four measures of centrality were analyzed in each network based on case assignments, and these measures were correlated with both rates of process measure compliance and clinical outcomes. Enhanced Recovery after Surgery provider teams led to a decrease in the closeness of anesthesiologists (p = 0.04) and significant increase in the clustering coefficient of certified registered nurse anesthetists (p = 0.005) compared with the pre-ERAS network. There was no significant change in centrality among surgeons (p = NS for all measures). Enhanced Recovery after Surgery designation among anesthesiologists and nurse anesthetists-whereby individual providers received an in-service on protocol elements and received compliance data was strongly associated with high compliance (>0.6 of measures; p < 0.001 for each group). In addition, high compliance was associated with a significant reduction in length of stay (p < 0.01), surgical site infection (p < 0.002), and morbidity (p < 0.009). Dedicated operating room teams led to increased centrality among anesthesia providers, which in turn not only increased compliance, but also improved several clinical outcomes. Copyright © 2017 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

High-definition video display based on the FPGA and THS8200

NASA Astrophysics Data System (ADS)

Qian, Jia; Sui, Xiubao

2014-11-01

This paper presents a high-definition video display solution based on the FPGA and THS8200. THS8200 is a video decoder chip launched by TI company, this chip has three 10-bit DAC channels which can capture video data in both 4:2:2 and 4:4:4 formats, and its data synchronization can be either through the dedicated synchronization signals HSYNC and VSYNC, or extracted from the embedded video stream synchronization information SAV / EAV code. In this paper, we will utilize the address and control signals generated by FPGA to access to the data-storage array, and then the FPGA generates the corresponding digital video signals YCbCr. These signals combined with the synchronization signals HSYNC and VSYNC that are also generated by the FPGA act as the input signals of THS8200. In order to meet the bandwidth requirements of the high-definition TV, we adopt video input in the 4:2:2 format over 2×10-bit interface. THS8200 is needed to be controlled by FPGA with I2C bus to set the internal registers, and as a result, it can generate the synchronous signal that is satisfied with the standard SMPTE and transfer the digital video signals YCbCr into analog video signals YPbPr. Hence, the composite analog output signals YPbPr are consist of image data signal and synchronous signal which are superimposed together inside the chip THS8200. The experimental research indicates that the method presented in this paper is a viable solution for high-definition video display, which conforms to the input requirements of the new high-definition display devices.

Time and frequency applications.

PubMed

Hellwig, H

1993-01-01

An overview is given of the capabilities of atomic clocks and quartz crystal oscillators in terms of available precision of time and frequency signals. The generation, comparison, and dissemination of time and frequency is then discussed. The principal focus is to survey uses of time and frequency in navigation, communication, and science. The examples given include the Global Positioning System, a satellite-based global navigation system, and general and dedicated communication networks, as well as experiments in general relativity and radioastronomy. The number of atomic clocks and crystal oscillators that are in actual use worldwide is estimated.

Present Status and Future Perspectives of the NEXT Experiment

DOE PAGES

Gómez Cadenas, J. J.; Álvarez, V.; Borges, F. I. G.; ...

2014-03-18

NEXT is an experiment dedicated to neutrinoless double beta decay searches in xenon. The detector is a TPC, holding 100 kg of high-pressure xenon enriched in the 136Xe isotope. It is under construction in the Laboratorio Subterráneo de Canfranc in Spain, and it will begin operations in 2015. The NEXT detector concept provides an energy resolutionbetter than 1% FWHM and a topological signal that can be used to reduce the background. Furthermore, the NEXT technology can be extrapolated to a 1 ton-scale experiment.

Sounding of the Ion Energization Region: Resolving Ambiguities

NASA Technical Reports Server (NTRS)

LaBelle, James

2003-01-01

Dartmouth College provided a single-channel high-frequency wave receiver to the Sounding of the Ion Energization Region: Resolving Ambiguities (SIERRA) rocket experiment launched from Poker Flat, Alaska, in January 2002. The receiver used signals from booms, probes, preamplifiers, and differential amplifiers provided by Cornell University coinvestigators. Output was to a dedicated 5 MHz telemetry link provided by WFF, with a small amount of additional Pulse Code Modulation (PCM) telemetry required for the receiver gain information. We also performed preliminary analysis of the data. The work completed is outlined below, in chronological order.

A Compton scattering setup for pulse shape discrimination studies in germanium detectors.

PubMed

von Sturm, K; Belogurov, S; Brugnera, R; Garfagnini, A; Lippi, I; Modenese, L; Rosso, D; Turcato, M

2017-07-01

Pulse shape discrimination is an important handle to improve sensitivity in low background experiments. A dedicated setup was built to investigate the response of high-purity germanium detectors to single Compton scattered events. Using properly collimated γ-ray sources, it is possible to select events with known interaction location. The aim is to correlate the position dependent signal shape with geometrical and electrical properties of the detector. We report on design and performance of the setup with a first look on data. Copyright © 2017 Elsevier Ltd. All rights reserved.

Computerized engineering logic for nuclear procurement and dedication processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tulay, M.P.

1996-12-31

In an attempt to better meet the needs of operations and maintenance organizations, many nuclear utility procurement engineering groups have simplified their procedures, developed on-line tools for performing the specification of replacement items, and developed relational databases containing part-level information necessary to automate the procurement process. Although these improvements have helped to reduce the engineering necessary to properly specify and accept/dedicate items for nuclear safety-related applications, a number of utilities have recognized that additional long-term savings can be realized by integrating a computerized logic to assist technical procurement engineering personnel. The most commonly used logic follows the generic processes containedmore » in Electric Power Research Institute (EPRI) published guidelines. The processes are typically customized to some extent to accommodate each utility`s organizational structure, operating procedures, and strategic goals. This paper will discuss a typical logic that integrates the technical evaluation, acceptance, and receipt inspection and testing processes. The logic this paper will describe has been successfully integrated at a growing number of nuclear utilities and has produced numerous positive results. The application of the logic ensures that utility-wide standards or procedures, common among multi-site utilities, are followed.« less

Modeling the impact of changing patient transportation systems on peri-operative process performance in a large hospital: insights from a computer simulation study.

PubMed

Segev, Danny; Levi, Retsef; Dunn, Peter F; Sandberg, Warren S

2012-06-01

Transportation of patients is a key hospital operational activity. During a large construction project, our patient admission and prep area will relocate from immediately adjacent to the operating room suite to another floor of a different building. Transportation will require extra distance and elevator trips to deliver patients and recycle transporters (specifically: personnel who transport patients). Management intuition suggested that starting all 52 first cases simultaneously would require many of the 18 available elevators. To test this, we developed a data-driven simulation tool to allow decision makers to simultaneously address planning and evaluation questions about patient transportation. We coded a stochastic simulation tool for a generalized model treating all factors contributing to the process as JAVA objects. The model includes elevator steps, explicitly accounting for transporter speed and distance to be covered. We used the model for sensitivity analyses of the number of dedicated elevators, dedicated transporters, transporter speed and the planned process start time on lateness of OR starts and the number of cases with serious delays (i.e., more than 15 min). Allocating two of the 18 elevators and 7 transporters reduced lateness and the number of cases with serious delays. Additional elevators and/or transporters yielded little additional benefit. If the admission process produced ready-for-transport patients 20 min earlier, almost all delays would be eliminated. Modeling results contradicted clinical managers' intuition that starting all first cases on time requires many dedicated elevators. This is explained by the principle of decreasing marginal returns for increasing capacity when there are other limiting constraints in the system.

Dedicated tool to assess the impact of a rhetorical task on human body temperature.

PubMed

Koprowski, Robert; Wilczyński, Sławomir; Martowska, Katarzyna; Gołuch, Dominik; Wrocławska-Warchala, Emilia

2017-10-01

Functional infrared thermal imaging is a method widely used in medicine, including analysis of the mechanisms related to the effect of emotions on physiological processes. The article shows how the body temperature may change during stress associated with performing a rhetorical task and proposes new parameters useful for dynamic thermal imaging measurements MATERIALS AND METHODS: 29 healthy male subjects were examined. They were given a rhetorical task that induced stress. Analysis and processing of collected body temperature data in a spatial resolution of 256×512pixels and a temperature resolution of 0.1°C enabled to show the dynamics of temperature changes. This analysis was preceded by dedicated image analysis and processing methods RESULTS: The presented dedicated algorithm for image analysis and processing allows for fully automated, reproducible and quantitative assessment of temperature changes and time constants in a sequence of thermal images of the patient. When performing the rhetorical task, the temperature rose by 0.47±0.19°C in 72.41% of the subjects, including 20.69% in whom the temperature decreased by 0.49±0.14°C after 237±141s. For 20.69% of the subjects only a drop in temperature was registered. For the remaining 6.89% of the cases, no temperature changes were registered CONCLUSIONS: The performance of the rhetorical task by the subjects causes body temperature changes. The ambiguous temperature response to the given stress factor indicates the complex mechanisms responsible for regulating stressful situations. Stress associated with the examination itself induces body temperature changes. These changes should always be taken into account in the analysis of infrared data. Copyright © 2017 Elsevier B.V. All rights reserved.

e-ASTROGAM mission: a major step forward for gamma-ray polarimetry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tatischeff, Vincent; De Angelis, Alessandro; Gouiffes, Christian

e-ASTROGAM is a gamma-ray space mission proposed for the fifth medium-size mission (M5) of the European Space Agency. It is dedicated to the study of the nonthermal universe in the photon energy range from ~ 0.15 MeV to 3 GeV with unprecedented sensitivity and angular and energy resolution, together with a ground-breaking capability for gamma-ray polarimetric measurements over its entire bandwidth. We discuss here the main polarization results expected at low energies, between 150 keV and 5 MeV, using Compton interactions in the e-ASTROGAM instrument, from observations of active galactic nuclei, gamma-ray bursts, microquasars, and the Crab Pulsar and Nebula.more » The anticipated performance of the proposed observatory for polarimetry is illustrated by simulations of the polarization signals expected from various sources. We show that polarimetric analyses with e-ASTROGAM should provide definitive insight into the geometry, magnetization, and content of the high-energy plasmas found in the emitting sources, as well as on the processes of radiation of these plasmas.« less

Noise and spectroscopic performance of DEPMOSFET matrix devices for XEUS

NASA Astrophysics Data System (ADS)

Treis, J.; Fischer, P.; Hälker, O.; Herrmann, S.; Kohrs, R.; Krüger, H.; Lechner, P.; Lutz, G.; Peric, I.; Porro, M.; Richter, R. H.; Strüder, L.; Trimpl, M.; Wermes, N.; Wölfel, S.

2005-08-01

DEPMOSFET based Active Pixel Sensor (APS) matrix devices, originally developed to cope with the challenging requirements of the XEUS Wide Field Imager, have proven to be a promising new imager concept for a variety of future X-ray imaging and spectroscopy missions like Simbol-X. The devices combine excellent energy resolution, high speed readout and low power consumption with the attractive feature of random accessibility of pixels. A production of sensor prototypes with 64 x 64 pixels with a size of 75 μm x 75 μm each has recently been finished at the MPI semiconductor laboratory in Munich. The devices are built for row-wise readout and require dedicated control and signal processing electronics of the CAMEX type, which is integrated together with the sensor onto a readout hybrid. A number of hybrids incorporating the most promising sensor design variants has been built, and their performance has been studied in detail. A spectroscopic resolution of 131 eV has been measured, the readout noise is as low as 3.5 e- ENC. Here, the dependence of readout noise and spectroscopic resolution on the device temperature is presented.

Pulse mode readout techniques for use with non-gridded industrial ionization chambers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Popov, Vladimir E.; Degtiarenko, Pavel V.

2011-10-01

Highly sensitive readout technique for precision long-term radiation measurements has been developed and tested in the Radiation Control Department at Jefferson Lab. The new electronics design is used to retrieve ionization data in a pulse mode. The dedicated data acquisition system works with M=Audio Audiophile 192 High-Definition 24-bit/192 kHz audio cards, taking data in continuous waveform recording mode. The on-line data processing algorithms extract signals of the ionization events from the data flow and measure the ionization value for each event. Two different ion chambers are evaluated. The first is a Reuter-Stokes Argon-filled (at 25 atm) High Pressure Ionization Chambermore » (HPIC), commonly used as a detector part in many GE Reuter-Stokes instruments of the RSS series. The second is a VacuTec Model 70181, 5 atm Xenon-filled ionization chamber. Results for both chambers indicate that the techniques allow using industrial ICs for high sensitivity and precision long-term radiation measurements, while at the same time providing information about spectral characteristics of the radiation fields.« less

Social pain and social gain in the adolescent brain: A common neural circuitry underlying both positive and negative social evaluation

PubMed Central

Dalgleish, Tim; Walsh, Nicholas D.; Mobbs, Dean; Schweizer, Susanne; van Harmelen, Anne-Laura; Dunn, Barnaby; Dunn, Valerie; Goodyer, Ian; Stretton, Jason

2017-01-01

Social interaction inherently involves the subjective evaluation of cues salient to social inclusion and exclusion. Testifying to the importance of such social cues, parts of the neural system dedicated to the detection of physical pain, the dorsal anterior cingulate cortex (dACC) and anterior insula (AI), have been shown to be equally sensitive to the detection of social pain experienced after social exclusion. However, recent work suggests that this dACC-AI matrix may index any socially pertinent information. We directly tested the hypothesis that the dACC-AI would respond to cues of both inclusion and exclusion, using a novel social feedback fMRI paradigm in a population-derived sample of adolescents. We show that the dACC and left AI are commonly activated by feedback cues of inclusion and exclusion. Our findings suggest that theoretical accounts of the dACC-AI network as a neural alarm system restricted within the social domain to the processing of signals of exclusion require significant revision. PMID:28169323

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

PubMed Central

Hornbeck, Peter V.; Zhang, Bin; Murray, Beth; Kornhauser, Jon M.; Latham, Vaughan; Skrzypek, Elzbieta

2015-01-01

PhosphoSitePlus® (PSP, http://www.phosphosite.org/), a knowledgebase dedicated to mammalian post-translational modifications (PTMs), contains over 330 000 non-redundant PTMs, including phospho, acetyl, ubiquityl and methyl groups. Over 95% of the sites are from mass spectrometry (MS) experiments. In order to improve data reliability, early MS data have been reanalyzed, applying a common standard of analysis across over 1 000 000 spectra. Site assignments with P > 0.05 were filtered out. Two new downloads are available from PSP. The ‘Regulatory sites’ dataset includes curated information about modification sites that regulate downstream cellular processes, molecular functions and protein-protein interactions. The ‘PTMVar’ dataset, an intersect of missense mutations and PTMs from PSP, identifies over 25 000 PTMVars (PTMs Impacted by Variants) that can rewire signaling pathways. The PTMVar data include missense mutations from UniPROTKB, TCGA and other sources that cause over 2000 diseases or syndromes (MIM) and polymorphisms, or are associated with hundreds of cancers. PTMVars include 18 548 phosphorlyation sites, 3412 ubiquitylation sites, 2316 acetylation sites, 685 methylation sites and 245 succinylation sites. PMID:25514926

e-ASTROGAM mission: a major step forward for gamma-ray polarimetry

DOE PAGES

Tatischeff, Vincent; De Angelis, Alessandro; Gouiffes, Christian; ...

2017-11-28

e-ASTROGAM is a gamma-ray space mission proposed for the fifth medium-size mission (M5) of the European Space Agency. It is dedicated to the study of the nonthermal universe in the photon energy range from ~ 0.15 MeV to 3 GeV with unprecedented sensitivity and angular and energy resolution, together with a ground-breaking capability for gamma-ray polarimetric measurements over its entire bandwidth. We discuss here the main polarization results expected at low energies, between 150 keV and 5 MeV, using Compton interactions in the e-ASTROGAM instrument, from observations of active galactic nuclei, gamma-ray bursts, microquasars, and the Crab Pulsar and Nebula.more » The anticipated performance of the proposed observatory for polarimetry is illustrated by simulations of the polarization signals expected from various sources. We show that polarimetric analyses with e-ASTROGAM should provide definitive insight into the geometry, magnetization, and content of the high-energy plasmas found in the emitting sources, as well as on the processes of radiation of these plasmas.« less

Design and Implementation of a Brain Computer Interface System for Controlling a Robotic Claw

NASA Astrophysics Data System (ADS)

Angelakis, D.; Zoumis, S.; Asvestas, P.

2017-11-01

The aim of this paper is to present the design and implementation of a brain-computer interface (BCI) system that can control a robotic claw. The system is based on the Emotiv Epoc headset, which provides the capability of simultaneous recording of 14 EEG channels, as well as wireless connectivity by means of the Bluetooth protocol. The system is initially trained to decode what user thinks to properly formatted data. The headset communicates with a personal computer, which runs a dedicated software application, implemented under the Processing integrated development environment. The application acquires the data from the headset and invokes suitable commands to an Arduino Uno board. The board decodes the received commands and produces corresponding signals to a servo motor that controls the position of the robotic claw. The system was tested successfully on a healthy, male subject, aged 28 years. The results are promising, taking into account that no specialized hardware was used. However, tests on a larger number of users is necessary in order to draw solid conclusions regarding the performance of the proposed system.

Note: A new method for directly reducing the sampling jitter noise of the digital phasemeter

NASA Astrophysics Data System (ADS)

Liang, Yu-Rong

2018-03-01

The sampling jitter noise is one non-negligible noise source of the digital phasemeter used for space gravitational wave detection missions. This note provides a new method for directly reducing the sampling jitter noise of the digital phasemeter, by adding a dedicated signal of which the frequency, amplitude, and initial phase should be pre-set. In contrast to the phase correction using the pilot-tone in the work of Burnett, Gerberding et al., Liang et al., Ales et al., Gerberding et al., and Ware et al. [M.Sc. thesis, Luleå University of Technology, 2010; Classical Quantum Gravity 30, 235029 (2013); Rev. Sci. Instrum. 86, 016106 (2015); Rev. Sci. Instrum. 86, 084502 (2015); Rev. Sci. Instrum. 86, 074501 (2015); and Proceedings of the Earth Science Technology Conference (NASA, USA, 2006)], the new method is intrinsically additive noise suppression. The experiment results validate that the new method directly reduces the sampling jitter noise without data post-processing and provides the same phase measurement noise level (10-6 rad/Hz1/2 at 0.1 Hz) as the pilot-tone correction.

Recent progress on the Axion Dark Matter eXperiment (ADMX)

NASA Astrophysics Data System (ADS)

Khatiwada, Rakshya; ADMX Collaboration

2017-01-01

The Axion Dark Matter eXperiment (ADMX) is one of the three ``Generation-2'' direct dark matter searches and the only one dedicated to finding the axion. It looks for axions that convert into photons through the Primakoff process in the presence of a strong magnetic field. The mass of the axion is unknown but expected to be few to tens of μeV, which corresponds to photons in the GHz range. The expected signal power is of the order 10-24 W, which puts stringent requirements on the system's noise level. ADMX has recently started its Generation-2 data run with the recent upgrades of a dilution refrigerator, which cools the system to sub-K temperature suppressing the thermal background noise and tunable, near quantum noise-limited SQUID amplifiers. This talk will summarize the current status and operation of ADMX experiment as it searches for dark matter axions. Supported by DOE Grants DE-SC0010280, DE-FG02-96ER40956, DE-AC52-07NA27344, DE-AC03-76SF00098, the Heising-Simons Foundation and the LLNL, FNAL and PNNL LDRD program.

Initial results from the NSTX Real-Time Velocity diagnostic

NASA Astrophysics Data System (ADS)

Podesta, M.; Bell, R. E.

2011-10-01

A new diagnostic for fast measurements of plasma rotation through active charge-exchange recombination spectroscopy (CHERS) was installed on NSTX. The diagnostic infers toroidal rotation from carbon ions undergoing charge-exchange with neutrals from a heating Neutral Beam (NB). Each of the 4 channels, distributed along the outer major radius, includes active views intercepting the NB and background views missing the beam. Estimated uncertainties in the measured velocity are <5% at the maximum sampling rate of 5000 Hz (or <1% at 1000 Hz), to be compared with <0.5% and 100 Hz of the main NSTX CHERS system. Signals are acquired on 2 CCD detectors, each controlled by a dedicated PC. Spectra are fitted in real-time through a C++ processing code and velocities are made available to the Plasma Control System for future implementation of feedback on velocity. Results from the initial operation during the 2011 run are discussed, emphasizing the fast dynamics of toroidal rotation, e . g . during L-H mode transition and breaking caused by instabilities and by externally-imposed magnetic perturbations. Work supported by USDOE Contract No. DE-AC02-09CH11466.

Dual ant colony operational modal analysis parameter estimation method

NASA Astrophysics Data System (ADS)

Sitarz, Piotr; Powałka, Bartosz

2018-01-01

Operational Modal Analysis (OMA) is a common technique used to examine the dynamic properties of a system. Contrary to experimental modal analysis, the input signal is generated in object ambient environment. Operational modal analysis mainly aims at determining the number of pole pairs and at estimating modal parameters. Many methods are used for parameter identification. Some methods operate in time while others in frequency domain. The former use correlation functions, the latter - spectral density functions. However, while some methods require the user to select poles from a stabilisation diagram, others try to automate the selection process. Dual ant colony operational modal analysis parameter estimation method (DAC-OMA) presents a new approach to the problem, avoiding issues involved in the stabilisation diagram. The presented algorithm is fully automated. It uses deterministic methods to define the interval of estimated parameters, thus reducing the problem to optimisation task which is conducted with dedicated software based on ant colony optimisation algorithm. The combination of deterministic methods restricting parameter intervals and artificial intelligence yields very good results, also for closely spaced modes and significantly varied mode shapes within one measurement point.

Millie Hughes-Fulford, Scientist and Prior Astronaut

NASA Image and Video Library

2014-03-13

CAPE CANAVERAL, Fla. - From left, T-cell science team members Emily Martinez, Miya Yoshida and Tara Candelario, of the Hughes-Fulford Laboratory, San Francisco, Calif., discuss preflight and post-flight experiment operations with researcher and principal investigator Dr. Millie Hughes-Fulford in the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The immunology experiment will launch on SpaceX-3 and focus on the effects of microgravity on early T-cell signaling pathways. Current work aims to identify and compare the gene expression of microRNAs miRNAs during T-cell activation under normal gravity and in microgravity, and compare those patterns to changes seen in aging populations. The experiment will be the first flown on SpaceX funded by the National Institutes of Health. Dr. Hughes-Fulford flew aboard space shuttle mission STS-40 in June 1991, the first Spacelab mission dedicated to biomedical studies. For more information on the T-cell experiment, visit http://hughesfulfordlab.com and http://www.nasa.gov/ames/research/space-biosciences/t-cell-activation-in-aging-spacex-3/. Photo credit: NASA/Cory Huston

Millie Hughes-Fulford, Scientist and Prior Astronaut

NASA Image and Video Library

2014-03-13

CAPE CANAVERAL, Fla. - T-cell science team member Tara Candelario of the Hughes-Fulford Laboratory, San Francisco, Calif., at the microscope, discusses preflight and post-flight experiment operations with researcher and principal investigator Dr. Millie Hughes-Fulford in the Space Station Processing Facility at NASA's Kennedy Space Center in Florida as T-cell science team members Emily Martinez, left, and Miya Yoshida look on. The immunology experiment will launch on SpaceX-3 and focus on the effects of microgravity on early T-cell signaling pathways. Current work aims to identify and compare the gene expression of microRNAs miRNAs during T-cell activation under normal gravity and in microgravity, and compare those patterns to changes seen in aging populations. The experiment will be the first flown on SpaceX funded by the National Institutes of Health. Dr. Hughes-Fulford flew aboard space shuttle mission STS-40 in June 1991, the first Spacelab mission dedicated to biomedical studies. For more information on the T-cell experiment, visit http://hughesfulfordlab.com and http://www.nasa.gov/ames/research/space-biosciences/t-cell-activation-in-aging-spacex-3/. Photo credit: NASA/Cory Huston

Millie Hughes-Fulford, Scientist and Prior Astronaut

NASA Image and Video Library

2014-03-13

CAPE CANAVERAL, Fla. - Researcher and principal investigator Dr. Millie Hughes-Fulford of the Hughes-Fulford Laboratory, San Francisco, Calif., at right, plans preflight and post-flight experiment operations with T-cell science team members Emily Martinez, left, and Tara Candelario in the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The immunology experiment will launch on SpaceX-3 and focus on the effects of microgravity on early T-cell signaling pathways. Current work aims to identify and compare the gene expression of microRNAs miRNAs during T-cell activation under normal gravity and in microgravity, and compare those patterns to changes seen in aging populations. The experiment will be the first flown on SpaceX funded by the National Institutes of Health. Dr. Hughes-Fulford flew aboard space shuttle mission STS-40 in June 1991, the first Spacelab mission dedicated to biomedical studies. For more information on the T-cell experiment, visit http://hughesfulfordlab.com and http://www.nasa.gov/ames/research/space-biosciences/t-cell-activation-in-aging-spacex-3/. Photo credit: NASA/Cory Huston

Millie Hughes-Fulford, Scientist and Prior Astronaut

NASA Image and Video Library

2014-03-13

CAPE CANAVERAL, Fla. - Researcher and former NASA payload specialist Millie Hughes-Fulford, of the Hughes-Fulford Laboratory, San Francisco, Calif., discusses her laboratory's T-cell experiment and the impact the research may have on aging adults and their immune systems with an interviewer in the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The immunology experiment will launch on SpaceX-3 and focus on the effects of microgravity on early T-cell signaling pathways. Current work aims to identify and compare the gene expression of microRNAs miRNAs during T-cell activation under normal gravity and in microgravity, and compare those patterns to changes seen in aging populations. The experiment will be the first flown on SpaceX funded by the National Institutes of Health. Dr. Hughes-Fulford flew aboard space shuttle mission STS-40 in June 1991, the first Spacelab mission dedicated to biomedical studies. For more information on the T-cell experiment, visit http://hughesfulfordlab.com and http://www.nasa.gov/ames/research/space-biosciences/t-cell-activation-in-aging-spacex-3/. Photo credit: NASA/Cory Huston

STEPP--Search Tool for Exploration of Petri net Paths: a new tool for Petri net-based path analysis in biochemical networks.

PubMed

Koch, Ina; Schueler, Markus; Heiner, Monika

2005-01-01

To understand biochemical processes caused by, e. g., mutations or deletions in the genome, the knowledge of possible alternative paths between two arbitrary chemical compounds is of increasing interest for biotechnology, pharmacology, medicine, and drug design. With the steadily increasing amount of data from high-throughput experiments new biochemical networks can be constructed and existing ones can be extended, which results in many large metabolic, signal transduction, and gene regulatory networks. The search for alternative paths within these complex and large networks can provide a huge amount of solutions, which can not be handled manually. Moreover, not all of the alternative paths are generally of interest. Therefore, we have developed and implemented a method, which allows us to define constraints to reduce the set of all structurally possible paths to the truly interesting path set. The paper describes the search algorithm and the constraints definition language. We give examples for path searches using this dedicated special language for a Petri net model of the sucrose-to-starch breakdown in the potato tuber.

STEPP - Search Tool for Exploration of Petri net Paths: A New Tool for Petri Net-Based Path Analysis in Biochemical Networks.

PubMed

Koch, Ina; Schüler, Markus; Heiner, Monika

2011-01-01

To understand biochemical processes caused by, e.g., mutations or deletions in the genome, the knowledge of possible alternative paths between two arbitrary chemical compounds is of increasing interest for biotechnology, pharmacology, medicine, and drug design. With the steadily increasing amount of data from high-throughput experiments new biochemical networks can be constructed and existing ones can be extended, which results in many large metabolic, signal transduction, and gene regulatory networks. The search for alternative paths within these complex and large networks can provide a huge amount of solutions, which can not be handled manually. Moreover, not all of the alternative paths are generally of interest. Therefore, we have developed and implemented a method, which allows us to define constraints to reduce the set of all structurally possible paths to the truly interesting path set. The paper describes the search algorithm and the constraints definition language. We give examples for path searches using this dedicated special language for a Petri net model of the sucrose-to-starch breakdown in the potato tuber. http://sanaga.tfh-berlin.de/~stepp/

Circularly-symmetric complex normal ratio distribution for scalar transmissibility functions. Part I: Fundamentals

NASA Astrophysics Data System (ADS)

Yan, Wang-Ji; Ren, Wei-Xin

2016-12-01

Recent advances in signal processing and structural dynamics have spurred the adoption of transmissibility functions in academia and industry alike. Due to the inherent randomness of measurement and variability of environmental conditions, uncertainty impacts its applications. This study is focused on statistical inference for raw scalar transmissibility functions modeled as complex ratio random variables. The goal is achieved through companion papers. This paper (Part I) is dedicated to dealing with a formal mathematical proof. New theorems on multivariate circularly-symmetric complex normal ratio distribution are proved on the basis of principle of probabilistic transformation of continuous random vectors. The closed-form distributional formulas for multivariate ratios of correlated circularly-symmetric complex normal random variables are analytically derived. Afterwards, several properties are deduced as corollaries and lemmas to the new theorems. Monte Carlo simulation (MCS) is utilized to verify the accuracy of some representative cases. This work lays the mathematical groundwork to find probabilistic models for raw scalar transmissibility functions, which are to be expounded in detail in Part II of this study.

Room temperature 1040fps, 1 megapixel photon-counting image sensor with 1.1um pixel pitch

NASA Astrophysics Data System (ADS)

Masoodian, S.; Ma, J.; Starkey, D.; Wang, T. J.; Yamashita, Y.; Fossum, E. R.

2017-05-01

A 1Mjot single-bit quanta image sensor (QIS) implemented in a stacked backside-illuminated (BSI) process is presented. This is the first work to report a megapixel photon-counting CMOS-type image sensor to the best of our knowledge. A QIS with 1.1μm pitch tapered-pump-gate jots is implemented with cluster-parallel readout, where each cluster of jots is associated with its own dedicated readout electronics stacked under the cluster. Power dissipation is reduced with this cluster readout because of the reduced column bus parasitic capacitance, which is important for the development of 1Gjot arrays. The QIS functions at 1040fps with binary readout and dissipates only 17.6mW, including I/O pads. The readout signal chain uses a fully differential charge-transfer amplifier (CTA) gain stage before a 1b-ADC to achieve an energy/bit FOM of 16.1pJ/b and 6.9pJ/b for the whole sensor and gain stage+ADC, respectively. Analog outputs with on-chip gain are implemented for pixel characterization purposes.

Image restoration for civil engineering structure monitoring using imaging system embedded on UAV

NASA Astrophysics Data System (ADS)

Vozel, Benoit; Dumoulin, Jean; Chehdi, Kacem

2013-04-01

Nowadays, civil engineering structures are periodically surveyed by qualified technicians (i.e. alpinist) operating visual inspection using heavy mechanical pods. This method is far to be safe, not only for civil engineering structures monitoring staff, but also for users. Due to the unceasing traffic increase, making diversions or closing lanes on bridge becomes more and more difficult. New inspection methods have to be found. One of the most promising technique is to develop inspection method using images acquired by a dedicated monitoring system operating around the civil engineering structures, without disturbing the traffic. In that context, the use of images acquired with an UAV, which fly around the structures is of particular interest. The UAV can be equipped with different vision system (digital camera, infrared sensor, video, etc.). Nonetheless, detection of small distresses on images (like cracks of 1 mm or less) depends on image quality, which is sensitive to internal parameters of the UAV (vibration modes, video exposure times, etc.) and to external parameters (turbulence, bad illumination of the scene, etc.). Though progresses were made at UAV level and at sensor level (i.e. optics), image deterioration is still an open problem. These deteriorations are mainly represented by motion blur that can be coupled with out-of-focus blur and observation noise on acquired images. In practice, deteriorations are unknown if no a priori information is available or dedicated additional instrumentation is set-up at UAV level. Image restoration processing is therefore required. This is a difficult problem [1-3] which has been intensively studied over last decades [4-12]. Image restoration can be addressed by following a blind approach or a myopic one. In both cases, it includes two processing steps that can be implemented in sequential or alternate mode. The first step carries out the identification of the blur impulse response and the second one makes use of this estimated blur kernel for performing the deconvolution of the acquired image. In the present work, different regularization methods, mainly based on the pseudo norm aforementioned Total Variation, are studied and analysed. The key point of their respective implementation, their properties and limits are investigated in this particular applicative context. References [1] J. Hadamard. Lectures on Cauchy's problem in linear partial differential equations. Yale University Press, 1923. [2] A. N. Tihonov. On the resolution of incorrectly posed problems and regularisation method (in Russian). Doklady A. N.SSSR, 151(3), 1963. [3] C. R. Vogel. Computational Methods for inverse problems, SIAM, 2002. [4] A. K. Katsaggelos, J. Biemond, R.W. Schafer, and R. M. Mersereau, "A regularized iterative image restoration algorithm," IEEE Transactions on Signal Processing, vol.39, no. 4, pp. 914-929, 1991. [5] J. Biemond, R. L. Lagendijk, and R. M. Mersereau, "Iterative methods for image deblurring," Proceedings of the IEEE, vol. 78, no. 5, pp. 856-883, 1990. [6] D. Kundur and D. Hatzinakos, "Blind image deconvolution," IEEE Signal Processing Magazine, vol. 13, no. 3, pp. 43-64, 1996. [7] Y. L. You and M. Kaveh, "A regularization approach to joint blur identification and image restoration," IEEE Transactions on Image Processing, vol. 5, no. 3, pp. 416-428, 1996. [8] T. F. Chan and C. K. Wong, "Total variation blind deconvolution," IEEE Transactions on Image Processing, vol. 7, no. 3, pp. 370-375, 1998. [9] S. Chardon, B. Vozel, and K. Chehdi. Parametric Blur Estimation Using the GCV Criterion and a Smoothness Constraint on the Image. Multidimensional Systems and Signal Processing Journal, Kluwer Ed., 10:395-414, 1999 [10] B. Vozel, K. Chehdi, and J. Dumoulin. Myopic image restoration for civil structures inspection using UAV (in French). In GRETSI, 2005. [11] L. Bar, N. Sochen, and N. Kiryati. Semi-blind image restoration via Mumford-Shah regularization. IEEE Transactions on Image Processing, 15(2), 2006. [12] J. H. Money and S. H. Kang, "Total variation minimizing blind deconvolution with shock filter reference," Image and Vision Computing, vol. 26, no. 2, pp. 302-314, 2008.

MR susceptibility imaging

NASA Astrophysics Data System (ADS)

Duyn, Jeff

2013-04-01

This work reviews recent developments in the use of magnetic susceptibility contrast for human MRI, with a focus on the study of brain anatomy. The increase in susceptibility contrast with modern high field scanners has led to novel applications and insights into the sources and mechanism contributing to this contrast in brain tissues. Dedicated experiments have demonstrated that in most of healthy brain, iron and myelin dominate tissue susceptibility variations, although their relative contribution varies substantially. Local variations in these compounds can affect both amplitude and frequency of the MRI signal. In white matter, the myelin sheath introduces an anisotropic susceptibility that has distinct effects on the water compartments inside the axons, between the myelin sheath, and the axonal space, and renders their signals dependent on the angle between the axon and the magnetic field. This offers opportunities to derive tissue properties specific to these cellular compartments.

The neural encoding of guesses in the human brain.

PubMed

Bode, Stefan; Bogler, Carsten; Soon, Chun Siong; Haynes, John-Dylan

2012-01-16

Human perception depends heavily on the quality of sensory information. When objects are hard to see we often believe ourselves to be purely guessing. Here we investigated whether such guesses use brain networks involved in perceptual decision making or independent networks. We used a combination of fMRI and pattern classification to test how visibility affects the signals, which determine choices. We found that decisions regarding clearly visible objects are predicted by signals in sensory brain regions, whereas different regions in parietal cortex became predictive when subjects were shown invisible objects and believed themselves to be purely guessing. This parietal network was highly overlapping with regions, which have previously been shown to encode free decisions. Thus, the brain might use a dedicated network for determining choices when insufficient sensory information is available. Copyright © 2011 Elsevier Inc. All rights reserved.

In situ measurements of fuel retention by laser induced desorption spectroscopy in TEXTOR

NASA Astrophysics Data System (ADS)

Zlobinski, M.; Philipps, V.; Schweer, B.; Huber, A.; Stoschus, H.; Brezinsek, S.; Samm, U.; TEXTOR Team

2011-12-01

In future fusion devices such as ITER tritium retention due to tritium co-deposition in mixed material layers can be a serious safety problem. Laser induced desorption spectroscopy (LIDS) can measure the hydrogen content of hydrogenic carbon layers locally on plasma-facing components, while hydrogen is used as a tritium substitute. For several years, this method has been applied in the TEXTOR tokamak in situ during plasma operation to monitor the hydrogen content in space and time. This work shows the LIDS signal reproducibility and studies the effects of different plasma conditions, desorption distances from the plasma and different laser energies using a dedicated sample with constant hydrogen amount. Also the LIDS signal evaluation procedure is described in detail and the detection limits for different conditions in the TEXTOR tokamak are estimated.

High-performance, multi-faceted research sonar electronics

NASA Astrophysics Data System (ADS)

Moseley, Julian W.

This thesis describes the design, implementation and testing of a research sonar system capable of performing complex applications such as coherent Doppler measurement and synthetic aperture imaging. Specifically, this thesis presents an approach to improve the precision of the timing control and increase the signal-to-noise ratio of an existing research sonar. A dedicated timing control subsystem, and hardware drivers are designed to improve the efficiency of the old sonar's timing operations. A low noise preamplifier is designed to reduce the noise component in the received signal arriving at the input of the system's data acquisition board. Noise analysis, frequency response, and timing simulation data are generated in order to predict the functionality and performance improvements expected when the subsystems are implemented. Experimental data, gathered using these subsys- tems, are presented, and are shown to closely match the simulation results, thus verifying performance.

CD147 regulates cancer migration via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling

PubMed Central

Feng, Fei; Wu, Jiao; Yang, Xiang-Min; Chen, Zhi-Nan; Jiang, Jian-Li

2016-01-01

The acquisition of inappropriate migratory feature is crucial for tumor metastasis. It has been suggested that CD147 and Annexin A2 are involved in regulating tumor cell movement, while the regulatory mechanisms are far from clear. In this study, we demonstrated that CD147 physically interacted with the N-terminal domain of Annexin A2 and decreased Annexin A2 phosphorylation on tyrosine 23. In vitro kinase assay showed that the I domain of CD147 was indispensable for CD147-mediated downregulation of Annexin A2 phosphorylation by Src. Furthermore, we determined that p-Annexin A2 promoted the expression of dedicator of cytokinesis 3 (DOCK3) and DOCK3 blocked β-catenin nuclear translocation, resulting in inhibition of β-catenin signaling. In addition, DOCK3 inhibited lamellipodium dynamics and tumor cell movement. Also, we found that β-catenin signaling increased WAVE2 expression. Therefore, DOCK3 was characterized as a negative regulator of WAVE2 expression via inhibiting β-catenin signaling. Our study provides the first evidence that CD147 promotes tumor cell movement and metastasis via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling axis. PMID:26716413

IXPE: The Imaging X-ray Polarimetry Explorer, Implementing a Dedicated Polarimetry Mission

NASA Technical Reports Server (NTRS)

Ramsey, Brian

2014-01-01

Only a few experiments have conducted x-ray polarimetry of cosmic sources since Weisskopf et al confirmed the 19% polarization of the Crab Nebula with the Orbiting Solar Observatory (OSO-8) in the 70's center dot The challenge is to measure a faint polarized component against a background of non-polarized signal (as well as the other, typical background components) center dot Typically, for a few % minimum detectable polarization, 106 photons are required. center dot So, a dedicated mission is vital with instruments that are designed specifically to measure polarization (with minimal systematic effects) Over the proposed mission life (2- 3 years), IXPE will first survey representative samples of several categories of targets: magnetars, isolated pulsars, pulsar wind nebula and supernova remnants, microquasars, active galaxies etc. The survey results will guide detailed follow-up observations. Precise calibration of IXPE is vital to ensuring sensitivity goals are met. The detectors will be characterized in Italy, and then a full calibration of the complete instrument will be performed at MSFC's stray light facility. Polarized flux at different energies Heritage: X-ray Optics at MSFC polarimetry mission.

Adjustable Nyquist-rate System for Single-Bit Sigma-Delta ADC with Alternative FIR Architecture

NASA Astrophysics Data System (ADS)

Frick, Vincent; Dadouche, Foudil; Berviller, Hervé

2016-09-01

This paper presents a new smart and compact system dedicated to control the output sampling frequency of an analogue-to-digital converters (ADC) based on single-bit sigma-delta (ΣΔ) modulator. This system dramatically improves the spectral analysis capabilities of power network analysers (power meters) by adjusting the ADC's sampling frequency to the input signal's fundamental frequency with a few parts per million accuracy. The trade-off between straightforwardness and performance that motivated the choice of the ADC's architecture are preliminary discussed. It particularly comes along with design considerations of an ultra-steep direct-form FIR that is optimised in terms of size and operating speed. Thanks to compact standard VHDL language description, the architecture of the proposed system is particularly suitable for application-specific integrated circuit (ASIC) implementation-oriented low-power and low-cost power meter applications. Field programmable gate array (FPGA) prototyping and experimental results validate the adjustable sampling frequency concept. They also show that the system can perform better in terms of implementation and power capabilities compared to dedicated IP resources.

Research and development of a dedicated collimator for 14.2 MeV fast neutrons for imaging using a D-T generator

NASA Astrophysics Data System (ADS)

Sabo-Napadensky, I.; Weiss-Babai, R.; Gayer, A.; Vartsky, D.; Bar, D.; Mor, I.; Chacham-Zada, R.; Cohen, M.; Tamim, N.

2012-06-01

One of the main problems in neutron imaging is the scattered radiation that accompanies the direct neutrons that reach the imaging detectors and affect the image quality. We have developed a dedicated collimator for 14.2 MeV fast neutrons. The collimator optimizes the amount of scattered radiation to primary neutrons that arrive at the imaging plane. We have used different materials within the collimator in order to lower the scattered radiation that arrives at the scanned object. The image quality and the signal to noise ratios that are measured show that a mixture of BORAX (Na2B4O7ṡ10H2O) and water in the experimental beam collimator give the best results. We have used GEANT4 to simulate the collimator performance, the simulations predict the optimized material looking on the ratios of the scattered to primary neutrons that contribute in the detector. We present our experimental setup, report the results of the experimental and related simulation studies with neutrons beam generated by a 14.2 MeV D-T neutron generator.

A solid-state dedicated circularly polarized luminescence spectrophotometer: Development and application.

PubMed

Harada, Takunori; Hayakawa, Hiroshi; Watanabe, Masayuki; Takamoto, Makoto

2016-07-01

A new solid-state dedicated circularly polarized luminescence (CPL) instrument (CPL-200CD) was successfully developed for measuring true CPL spectra for optically anisotropic samples on the basis of the Stokes-Mueller matrix approach. Electric components newly installed in the CPL-200CD include a pulse motor-driven sample rotation holder and a 100 kHz lock-in amplifier to achieve the linearly polarized luminescence measurement, which is essential for obtaining the true CPL signal for optically anisotropic samples. An acquisition approach devised for solid-state CPL analysis reduces the measurement times for a data set by ca. 98% compared with the time required in our previous method. As a result, the developed approach is very effective for samples susceptible to light-induced degradation. The theory and implementation of the method are described, and examples of its application to a CPL sample with macroscopic anisotropies are provided. An important advantage of the developed instrument is its ability to obtain molecular information for both excited and ground states because circular dichroism measurements can be performed by switching the monochromatic light to white light without rearrangement of the sample.

WARP: Weight Associative Rule Processor. A dedicated VLSI fuzzy logic megacell

NASA Technical Reports Server (NTRS)

Pagni, A.; Poluzzi, R.; Rizzotto, G. G.

1992-01-01

During the last five years Fuzzy Logic has gained enormous popularity in the academic and industrial worlds. The success of this new methodology has led the microelectronics industry to create a new class of machines, called Fuzzy Machines, to overcome the limitations of traditional computing systems when utilized as Fuzzy Systems. This paper gives an overview of the methods by which Fuzzy Logic data structures are represented in the machines (each with its own advantages and inefficiencies). Next, the paper introduces WARP (Weight Associative Rule Processor) which is a dedicated VLSI megacell allowing the realization of a fuzzy controller suitable for a wide range of applications. WARP represents an innovative approach to VLSI Fuzzy controllers by utilizing different types of data structures for characterizing the membership functions during the various stages of the Fuzzy processing. WARP dedicated architecture has been designed in order to achieve high performance by exploiting the computational advantages offered by the different data representations.

Knowledge Exchange in the Shrines of Knowledge: The ''How's'' and ''Where's'' of Knowledge Sharing Processes

ERIC Educational Resources Information Center

Reychav, Iris; Te'eni, Dov

2009-01-01

Academic conferences are places of situated learning dedicated to the exchange of knowledge. Knowledge is exchanged between colleagues who are looking to enhance their future research by taking part in several formal and informal settings (lectures, discussions and social events). We studied the processes of knowledge sharing and the influence of…

ESF GROUND SUPPORT - MATERIAL DEDICATION ANALYSIS FOR STRUCTURAL STEEL AND ACCESSORIES FROM A COMMERCIAL GRADE SOURCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

M.D. Stine

1996-01-23

The purpose of this analysis is to select the critical characteristics to be verified for steel sets and accessories and the verification methods to be implemented through a material dedication process for the procurement and use of commercial grade structural steel sets and accessories (which have a nuclear safety function) to be used in ground support (with the exception of alcove ground support and alcove opening framing, which are not addressed in this analysis) for the Exploratory Studies Facility (ESF) Topopah Spring (TS) Loop. The ESF TS Loop includes the North Ramp, Main Drift, and South Ramp underground openings.

MMS Partial Solar Array Inspection

NASA Image and Video Library

2014-11-14

A plaque affixed to the side of a Magnetospheric Multiscale, or MMS, observatory dedicates the mission to Richard “Richy” D’Antonio, now deceased, in grateful appreciation for his dedicated service to NASA’s MMS mission. MMS, led by a team from NASA's Goddard Space Flight Center, is a Solar Terrestrial Probes mission consisting of four identically instrumented spacecraft that will use Earth’s magnetosphere as a laboratory to study the microphysics of three fundamental plasma processes: magnetic reconnection, energetic particle acceleration and turbulence. Launch aboard a United Launch Alliance Atlas V rocket from Space Launch Complex 41 on Cape Canaveral Air Force Station is targeted for March 12, 2015.

The psychological aspects of a well-known issue

NASA Astrophysics Data System (ADS)

Arka, Ioanna

2018-01-01

From the PhD through several post-doctoral positions, to the few permanent academic posts, the selection processes determining who will populate the upper echelons of academic astronomy might not involve just merit, hard work or dedication.

Shared neural coding for social hierarchy and reward value in primate amygdala.

PubMed

Munuera, Jérôme; Rigotti, Mattia; Salzman, C Daniel

2018-03-01

The social brain hypothesis posits that dedicated neural systems process social information. In support of this, neurophysiological data have shown that some brain regions are specialized for representing faces. It remains unknown, however, whether distinct anatomical substrates also represent more complex social variables, such as the hierarchical rank of individuals within a social group. Here we show that the primate amygdala encodes the hierarchical rank of individuals in the same neuronal ensembles that encode the rewards associated with nonsocial stimuli. By contrast, orbitofrontal and anterior cingulate cortices lack strong representations of hierarchical rank while still representing reward values. These results challenge the conventional view that dedicated neural systems process social information. Instead, information about hierarchical rank-which contributes to the assessment of the social value of individuals within a group-is linked in the amygdala to representations of rewards associated with nonsocial stimuli.

Next-generation applications in healthcare digital libraries using semantic service composition and coordination.

PubMed

Möller, Thorsten; Schuldt, Heiko; Gerber, Andreas; Klusch, Matthias

2006-06-01

Healthcare digital libraries (DLs) increasingly make use of dedicated services to access functionality and/or data. Semantic (web) services enhance single services and facilitate compound services, thereby supporting advanced applications on top of a DL. The traditional process management approach tends to focus on process definition at build time rather than on actual service events in run time, and to anticipate failures in order to define appropriate strategies. This paper presents a novel approach where service coordination is distributed among a set of agents. A dedicated component plans compound semantic services on demand for a particular application. In failure, the planner is reinvoked to define contin- gency strategies. Finally, matchmaking is effected at runtime by choosing the appropriate service provider. These combined technologies will provide key support for highly flexible next-generation DL applications. Such technologies are under development within CASCOM.

A dedicated network for social interaction processing in the primate brain.

PubMed

Sliwa, J; Freiwald, W A

2017-05-19

Primate cognition requires interaction processing. Interactions can reveal otherwise hidden properties of intentional agents, such as thoughts and feelings, and of inanimate objects, such as mass and material. Where and how interaction analyses are implemented in the brain is unknown. Using whole-brain functional magnetic resonance imaging in macaque monkeys, we discovered a network centered in the medial and ventrolateral prefrontal cortex that is exclusively engaged in social interaction analysis. Exclusivity of specialization was found for no other function anywhere in the brain. Two additional networks, a parieto-premotor and a temporal one, exhibited both social and physical interaction preference, which, in the temporal lobe, mapped onto a fine-grain pattern of object, body, and face selectivity. Extent and location of a dedicated system for social interaction analysis suggest that this function is an evolutionary forerunner of human mind-reading capabilities. Copyright © 2017, American Association for the Advancement of Science.

Characteristics and Limitations of Submerged GPS L1 Observations

NASA Astrophysics Data System (ADS)

Steiner, Ladina; Geiger, Alain

2017-04-01

Extensive amount of water stored in snow covers has a high impact on flood development during snow melting periods. Early assessment of these parameters in mountain environments enhance early-warning and thus prevention of major impacts. Sub-snow GNSS techniques are lately suggested to determine liquid water content, snow water equivalent or considered for avalanche rescue. This technique is affordable, flexible, and provides accurate and continuous observations independent on weather conditions. However, the characteristics of GNSS observations for applications within a snow-pack still need to be further investigated. The magnitude of the main interaction processes involved for the GPS wavelength propagating through different layers of snow, ice or water is theoretically examined. Liquid water exerts the largest influence on GPS signal propagation through a snow-pack. Therefore, we focus on determining the characteristics of GNSS observables under water. An experiment was set-up to investigate the characteristics and limitations of submerged GPS observations using a pool, a level control by communicating pipes, a geodetic and a low-cost GPS antenna, and a water level sensor. The GPS antennas were placed into the water. The water level was increased daily by a step of two millimeters up to thirty millimeters above the antenna. Based on this experiment, the signal penetration depth, satellite availability, the attenuation of signal strength and the quality of solutions are analyzed. Our experimental results show an agreement with the theoretically derived attenuation parameter and signal penetration depth. The assumption of water as the limiting parameter for GPS observations within a snow-pack can be confirmed. Higher wetness in a snow-pack leads to less transmission, higher refraction, higher attenuation and thus a decreased penetration depth as well as a reduced quality of the solutions. In consequence, GPS applications within a snow-pack are heavily impacted by wetness which is even more pronounced during melting period. In this poster, we present a short introduction to the principle, explain the developed algorithms and show results of experiments dedicated to the signal propagation in water.

AVIRIS ground data-processing system

NASA Technical Reports Server (NTRS)

Reimer, John H.; Heyada, Jan R.; Carpenter, Steve C.; Deich, William T. S.; Lee, Meemong

1987-01-01

The Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) has been under development at JPL for the past four years. During this time, a dedicated ground data-processing system has been designed and implemented to store and process the large amounts of data expected. This paper reviews the objectives of this ground data-processing system and describes the hardware. An outline of the data flow through the system is given, and the software and incorporated algorithms developed specifically for the systematic processing of AVIRIS data are described.

Is Einsteinian no-signalling violated in Bell tests?

NASA Astrophysics Data System (ADS)

Kupczynski, Marian

2017-11-01

Relativistic invariance is a physical law verified in several domains of physics. The impossibility of faster than light influences is not questioned by quantum theory. In quantum electrodynamics, in quantum field theory and in the standard model relativistic invariance is incorporated by construction. Quantum mechanics predicts strong long range correlations between outcomes of spin projection measurements performed in distant laboratories. In spite of these strong correlations marginal probability distributions should not depend on what was measured in the other laboratory what is called shortly: non-signalling. In several experiments, performed to test various Bell-type inequalities, some unexplained dependence of empirical marginal probability distributions on distant settings was observed. In this paper we demonstrate how a particular identification and selection procedure of paired distant outcomes is the most probable cause for this apparent violation of no-signalling principle. Thus this unexpected setting dependence does not prove the existence of superluminal influences and Einsteinian no-signalling principle has to be tested differently in dedicated experiments. We propose a detailed protocol telling how such experiments should be designed in order to be conclusive. We also explain how magical quantum correlations may be explained in a locally causal way.

Measurements on wireless transmission of ECG signals

NASA Astrophysics Data System (ADS)

Gabrielli, A.; Lax, I.

2016-12-01

The scope of this research is to design an electronic prototype, an operative system as a proof of concept, to transmit and receive biological parameters, in particular electrocardiogram signals, through dedicated wireless circuits. The apparatus features microelectronics chips that were developed for more general biomedical applications, here adapted to deal with cardiac signals. The paper mainly focuses on the electronic aspects, as in this study we do not face medical or clinical aspects of the system. The transmitter circuit uses a commercial instrumentation amplifier and the receiver has been equipped with wide-band amplifiers along with made-in-the-lab band-pass filters centered at the carrier. We have been able to mount the entire system prototype into a preliminary data acquisition chain that reads out the electrocardiogram signal. The prototype allows acquiring the waveform, converting it to a digital pattern and open the transmission through a series of high-frequency packets exploiting the Ultra Wide Band protocol. The sensor value is embedded in the transmission through the rate of the digital packets. In fact, these are sent wireless at a specific packet-frequency that depends on the sensor amplitude and are detected into a receiver circuit that recovers the information.

Slab Geometry and Segmentation on Seismogenic Subduction Zone; Insight from gravity gradients

NASA Astrophysics Data System (ADS)

Saraswati, A. T.; Mazzotti, S.; Cattin, R.; Cadio, C.

2017-12-01

Slab geometry is a key parameter to improve seismic hazard assessment in subduction zones. In many cases, information about structures beneath subduction are obtained from geophysical dedicated studies, including geodetic and seismic measurements. However, due to the lack of global information, both geometry and segmentation in seismogenic zone of many subductions remain badly-constrained. Here we propose an alternative approach based on satellite gravity observations. The GOCE (Gravity field and steady-state Ocean Circulation Explorer) mission enables to probe Earth deep mass structures from gravity gradients, which are more sensitive to spatial structure geometry and directional properties than classical gravitational data. Gravity gradients forward modeling of modeled slab is performed by using horizontal and vertical gravity gradient components to better determine slab geophysical model rather than vertical gradient only. Using polyhedron method, topography correction on gravity gradient signal is undertaken to enhance the anomaly signal of lithospheric structures. Afterward, we compare residual gravity gradients with the calculated signals associated with slab geometry. In this preliminary study, straightforward models are used to better understand the characteristic of gravity gradient signals due to deep mass sources. We pay a special attention to the delineation of slab borders and dip angle variations.

Comparative Monte Carlo study on the performance of integration- and list-mode detector configurations for carbon ion computed tomography

NASA Astrophysics Data System (ADS)

Meyer, Sebastian; Gianoli, Chiara; Magallanes, Lorena; Kopp, Benedikt; Tessonnier, Thomas; Landry, Guillaume; Dedes, George; Voss, Bernd; Parodi, Katia

2017-02-01

Ion beam therapy offers the possibility of a highly conformal tumor-dose distribution; however, this technique is extremely sensitive to inaccuracies in the treatment procedures. Ambiguities in the conversion of Hounsfield units of the treatment planning x-ray CT to relative stopping power (RSP) can cause uncertainties in the estimated ion range of up to several millimeters. Ion CT (iCT) represents a favorable solution allowing to directly assess the RSP. In this simulation study we investigate the performance of the integration-mode configuration for carbon iCT, in comparison with a single-particle approach under the same set-up. The experimental detector consists of a stack of 61 air-filled parallel-plate ionization chambers, interleaved with 3 mm thick PMMA absorbers. By means of Monte Carlo simulations, this design was applied to acquire iCTs of phantoms of tissue-equivalent materials. An optimization of the acquisition parameters was performed to reduce the dose exposure, and the implications of a reduced absorber thickness were assessed. In order to overcome limitations of integration-mode detection in the presence of lateral tissue heterogeneities a dedicated post-processing method using a linear decomposition of the detector signal was developed and its performance was compared to the list-mode acquisition. For the current set-up, the phantom dose could be reduced to below 30 mGy with only minor image quality degradation. By using the decomposition method a correct identification of the components and a RSP accuracy improvement of around 2.0% was obtained. The comparison of integration- and list-mode indicated a slightly better image quality of the latter, with an average median RSP error below 1.8% and 1.0%, respectively. With a decreased absorber thickness a reduced RSP error was observed. Overall, these findings support the potential of iCT for low dose RSP estimation, showing that integration-mode detectors with dedicated post-processing strategies can provide a RSP accuracy comparable to list-mode configurations.

Synthetic Aperture Radar (SAR) data processing

NASA Technical Reports Server (NTRS)

Beckner, F. L.; Ahr, H. A.; Ausherman, D. A.; Cutrona, L. J.; Francisco, S.; Harrison, R. E.; Heuser, J. S.; Jordan, R. L.; Justus, J.; Manning, B.

1978-01-01

The available and optimal methods for generating SAR imagery for NASA applications were identified. The SAR image quality and data processing requirements associated with these applications were studied. Mathematical operations and algorithms required to process sensor data into SAR imagery were defined. The architecture of SAR image formation processors was discussed, and technology necessary to implement the SAR data processors used in both general purpose and dedicated imaging systems was addressed.

Routine Analysis of all available GNSS Stations in Greece: Processing Scheme and Dissemination of Products and Data.

NASA Astrophysics Data System (ADS)

Papanikolaou, Xanthos; Anastasiou, Demitris; Marinou, Aggeliki; Zacharis, Vangelis; Paradissis, Demitris

2015-04-01

Dionysos Satellite Observatory and Higher Geodesy Laboratory of the National Technical University of Athens, have developed an automated processing scheme to accommodate the daily analysis of all available continuous GNSS stations in Greece. For the moment, a total of approximately 150 regional stations are processed, divided in 4 subnetworks. GNSS data are processed routinely on a daily basis, via Bernese GNSS Software v5.0, developed by AIUB. Each network is solved twice, within a period of 20 days, first using ultra-rapid products (with a latency of ~10 hours) and then using final products (with a latency of ~20 days). Observations are processed using carrier phase, modelled to double differences in the ionosphere-free linear combination. Analysis results, include coordinate estimates, ionospheric corrections (TEC maps) and hourly tropospheric parameters (zenith delay). This processing scheme, has proved helpful in investigating in near real-time abrupt geophysical phenomena, as in the 2011 Santorini inflation episode and the 2014 Kephalonia earthquake events. All analysis results and products are made available via a dedicated webpage. Additionally, most of the GNSS data are hosted in a GSAC web platform, available to all interested parties. Data and results are made available through the laboratory's dedicated website: http://dionysos.survey.ntua.gr/.

Feasibility study of 235U and 239Pu characterization in radioactive waste drums using neutron-induced fission delayed gamma rays

NASA Astrophysics Data System (ADS)

Nicol, T.; Pérot, B.; Carasco, C.; Brackx, E.; Mariani, A.; Passard, C.; Mauerhofer, E.; Collot, J.

2016-10-01

This paper reports a feasibility study of 235U and 239Pu characterization in 225 L bituminized waste drums or 200 L concrete waste drums, by detecting delayed fission gamma rays between the pulses of a deuterium-tritium neutron generator. The delayed gamma yields were first measured with bare samples of 235U and 239Pu in REGAIN, a facility dedicated to the assay of 118 L waste drums by Prompt Gamma Neutron Activation Analysis (PGNAA) at CEA Cadarache, France. Detectability in the waste drums is then assessed using the MCNPX model of MEDINA (Multi Element Detection based on Instrumental Neutron Activation), another PGNAA cell dedicated to 200 L drums at FZJ, Germany. For the bituminized waste drum, performances are severely hampered by the high gamma background due to 137Cs, which requires the use of collimator and shield to avoid electronics saturation, these elements being very penalizing for the detection of the weak delayed gamma signal. However, for lower activity concrete drums, detection limits range from 10 to 290 g of 235U or 239Pu, depending on the delayed gamma rays of interest. These detection limits have been determined by using MCNPX to calculate the delayed gamma useful signal, and by measuring the experimental gamma background in MEDINA with a 200 L concrete drum mock-up. The performances could be significantly improved by using a higher interrogating neutron emission and an optimized experimental setup, which would allow characterizing nuclear materials in a wide range of low and medium activity waste packages.

SLAPex Freeze/Thaw 2015: The First Dedicated Soil Freeze/Thaw Airborne Campaign

NASA Technical Reports Server (NTRS)

Kim, Edward; Wu, Albert; DeMarco, Eugenia; Powers, Jarrett; Berg, Aaron; Rowlandson, Tracy; Freeman, Jacqueline; Gottfried, Kurt; Toose, Peter; Roy, Alexandre;

Evaluation of a recombinant insect-derived amylase performance in simultaneous saccharification and fermentation process with industrial yeasts.

PubMed

Celińska, Ewelina; Borkowska, Monika; Białas, Wojciech

2016-03-01

Starch is the dominant feedstock consumed for the bioethanol production, accounting for 60 % of its global production. Considering the significant contribution of bioethanol to the global fuel market, any improvement in its major operating technologies is economically very attractive. It was estimated that up to 40 % of the final ethanol unit price is derived from the energy input required for the substrate pre-treatment. Application of raw starch hydrolyzing enzymes (RSHE), combined with operation of the process according to a simultaneous saccharification and fermentation (SSF) strategy, constitutes the most promising solutions to the current technologies limitations. In this study, we expressed the novel RSHE derived from an insect in Saccharomyces cerevisiae strain dedicated for the protein overexpression. Afterwards, the enzyme performance was assessed in SSF process conducted by industrial ethanologenic or thermotolerant yeast species. Comparison of the insect-derived RSHE preparation with commercially available amylolytic RSH preparation was conducted. Our results demonstrate that the recombinant alpha-amylase from rice weevil can be efficiently expressed and secreted with its native signal peptide in S. cerevisiae INVSc-pYES2-Amy1 expression system (accounting for nearly 72 % of the strain's secretome). Application of the recombinant enzyme-based preparation in SSF process secured sufficient amylolytic activity for the yeast cell propagation and ethanol formation from raw starch. (Oligo)saccharide profiles generated by the compared preparations differed with respect to homogeneity of the sugar mixtures. Concomitantly, as demonstrated by a kinetic model developed in this study, the kinetic parameters describing activity of the compared preparations were different.

Tsukuba VLBI Correlator

NASA Technical Reports Server (NTRS)

Kurihara, Shinobu; Nozawa, Kentaro

2013-01-01

The K5/VSSP software correlator (Figure 1), located in Tsukuba, Japan, is operated by the Geospatial Information Authority of Japan (GSI). It is fully dedicated to processing the geodetic VLBI sessions of the International VLBI Service for Geodesy and Astrometry. All of the weekend IVS Intensives (INT2) and the Japanese domestic VLBI observations organized by GSI were processed at the Tsukuba VLBI Correlator.

Overview of the dairy and food processing research conducted at the Dairy and Functional Foods Research Unit, ERRC, and research to develop sustainable food processes

USDA-ARS?s Scientific Manuscript database

The DFFRU is dedicated to solving critical problems in the utilization of milk and specialty crop byproducts by developing high-quality, value-added functional foods and consumer products. The presentation will give an overview of the research projects that will benefit human health and well-being. ...

Application of Context Input Process and Product Model in Curriculum Evaluation: Case Study of a Call Centre

ERIC Educational Resources Information Center

Kavgaoglu, Derya; Alci, Bülent

2016-01-01

The goal of this research which was carried out in reputable dedicated call centres within the Turkish telecommunication sector aims is to evaluate competence-based curriculums designed by means of internal funding through Stufflebeam's context, input, process, product (CIPP) model. In the research, a general scanning pattern in the scope of…

Counterinsurgency Aircraft Procurement Options: Processes, Methods, Alternatives, and Estimates

DTIC Science & Technology

2009-08-01

4. TITLE AND SUBTITLE Counterinsurgency Aircraft Procurement Options: Processes, Methods, Alternatives, and Estimates 5a. CONTRACT NUMBER 5b...Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT A call is being made for an aircraft dedicated to the...counterinsurgency (COIN) mission within military academic circles and the special operations community. Support for a COIN aircraft needs hard numbers, given

Superintendent Searches Public or Confidential? The Case for an Open Search Process

ERIC Educational Resources Information Center

Davis, Terre

2010-01-01

Board of education members come and go, but the community remains. Wise candidates for a superintendent position, as well as the dedicated board members involved in fulfilling this important duty, understand this and therefore want the public to be part of the superintendent search process. As a search consultant to school boards for 20 years, the…

Eco-Balance analysis of the disused lead-acid-batteries recycling technology

NASA Astrophysics Data System (ADS)

Kamińska, Ewa; Kamiński, Tomasz

2017-10-01

The article presents the results of the eco-balance analysis of the disused lead-acid batteries recycling process. Test-dedicated technology offers the possibility to recover other elements, for example, polypropylene of the battery case or to obtain crystalline sodium sulphate. The life cycle assessment was made using ReCiPe and IMPACT2002 + methods. The results are shown as environmental points [Pt]. The results are shown in the environmental categories, specific for each of the methods grouped in the impact categories. 1 Mg of the processed srap was a dopted as the functional unit. The results of the analyses indicate that recycling processes may provide the environmental impact of recycling technology less harmful. Repeated use of lead causes that its original sources are not explored. Similarly, the use of granule production-dedicated polypropylene extracted from battery casings that are used in the plastics industry, has environmental benefits. Due to the widespread use of lead-acid batteries, the attention should be paid to their proper utilization, especially in terms of heavy metals, especially lead. According to the calculations, the highest level of environmental benefits from the use of lead from secondary sources in the production of new products, was observed in the refining process.

UOE Pipe Manufacturing Process Simulation: Equipment Designing and Construction

NASA Astrophysics Data System (ADS)

Delistoian, Dmitri; Chirchor, Mihael

2017-12-01

UOE pipe manufacturing process influence directly on pipeline resilience and operation capacity. At present most spreaded pipe manufacturing method is UOE. This method is based on cold forming. After each technological step appears a certain stress and strain level. For pipe stress strain study is designed and constructed special equipment that simulate entire technological process.UOE pipe equipment is dedicated for manufacturing of longitudinally submerged arc welded DN 400 (16 inch) steel pipe.

Enhancement of efficiency of storage and processing of food raw materials using radiation technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gracheva, A. Yu.; Zav’yalov, M. A.; Ilyukhina, N. V.

The work is dedicated to improvement of efficiency of storage and processing of food raw materials using radiation technologies. International practice of radiation processing of food raw materials is presented and an increase in the consumption of irradiated food products is shown. The prospects of using radiation technologies for the processing of food products in Russia are discussed. The results of studies of radiation effects on various food products and packaging film by γ radiation and accelerated electrons are presented.

Space processes for extended low-G testing

NASA Technical Reports Server (NTRS)

Steurer, W. H.; Kaye, S.; Gorham, D. J.

1973-01-01

Results of an investigation of verifying the capabilities of space processes in ground based experiments at low-g periods are presented. Limited time experiments were conducted with the processes. A valid representation of the complete process cycle was achieved at low-g periods ranging from 40 to 390 seconds. A minimum equipment inventory, is defined. A modular equipment design, adopted to assure low cost and high program flexibility, is presented as well as procedures and data established for the synthesis and definition of dedicated and mixed rocket payloads.

Energy Secretary Dedicates ESIF at NREL | News | NREL

Science.gov Websites

-like screen how wind turbine blades can alter the wind flow as it approaches other turbines downstream flows downstream when the blades hit it. A man with his back to the camera explains the process, while

Problems of Pedagogical Creativity Development

ERIC Educational Resources Information Center

Ibragimkyzy, Shynar; Slambekova, Tolkyn S.; Saylaubay, Yerlan E.; Albytova, Nazymgul

2016-01-01

This article provides analysis of research papers by different scholars, dedicated to topical issues of pedagogical creativity development in the educational process. The authors determined that pedagogical creativity could be considered at five levels: information-reproducing, adaptive-prognostic, innovative, research and creative-prognostic. In…

FPGA Implementation of Heart Rate Monitoring System.

PubMed

Panigrahy, D; Rakshit, M; Sahu, P K

2016-03-01

This paper describes a field programmable gate array (FPGA) implementation of a system that calculates the heart rate from Electrocardiogram (ECG) signal. After heart rate calculation, tachycardia, bradycardia or normal heart rate can easily be detected. ECG is a diagnosis tool routinely used to access the electrical activities and muscular function of the heart. Heart rate is calculated by detecting the R peaks from the ECG signal. To provide a portable and the continuous heart rate monitoring system for patients using ECG, needs a dedicated hardware. FPGA provides easy testability, allows faster implementation and verification option for implementing a new design. We have proposed a five-stage based methodology by using basic VHDL blocks like addition, multiplication and data conversion (real to the fixed point and vice-versa). Our proposed heart rate calculation (R-peak detection) method has been validated, using 48 first channel ECG records of the MIT-BIH arrhythmia database. It shows an accuracy of 99.84%, the sensitivity of 99.94% and the positive predictive value of 99.89%. Our proposed method outperforms other well-known methods in case of pathological ECG signals and successfully implemented in FPGA.

Microbial whole‐cell arrays

PubMed Central

Elad, Tal; Lee, Jin Hyung; Belkin, Shimshon; Gu, Man Bock

2008-01-01

Summary The coming of age of whole‐cell biosensors, combined with the continuing advances in array technologies, has prepared the ground for the next step in the evolution of both disciplines – the whole‐cell array. In the present review, we highlight the state‐of‐the‐art in the different disciplines essential for a functional bacterial array. These include the genetic engineering of the biological components, their immobilization in different polymers, technologies for live cell deposition and patterning on different types of solid surfaces, and cellular viability maintenance. Also reviewed are the types of signals emitted by the reporter cell arrays, some of the transduction methodologies for reading these signals and the mathematical approaches proposed for their analysis. Finally, we review some of the potential applications for bacterial cell arrays, and list the future needs for their maturation: a richer arsenal of high‐performance reporter strains, better methodologies for their incorporation into hardware platforms, design of appropriate detection circuits, the continuing development of dedicated algorithms for multiplex signal analysis and – most importantly – enhanced long‐term maintenance of viability and activity on the fabricated biochips. PMID:21261831

Quantification of water content by laser induced breakdown spectroscopy on Mars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rapin, W.; Meslin, P. -Y.; Maurice, S.

Laser induced breakdown spectroscopy (LIBS), as performed by the ChemCam instrument, provides a new technique to measure hydrogen at the surface of Mars. Using a laboratory replica of the LIBS instrument onboard the Curiosity rover, different types of hydrated samples (basalts, calcium and magnesium sulfates, opals and apatites) covering a range of targets observed on Mars have been characterized and analyzed in this paper. A number of factors related to laser parameters, atmospheric conditions and differences in targets properties can affect the standoff LIBS signal, and in particular the hydrogen emission peak. Dedicated laboratory tests were run to identify amore » normalization of the hydrogen signal which could best compensate for these effects and enable the application of the laboratory calibration to Mars data. We check that the hydrogen signal increases linearly with water content; and normalization of the hydrogen emission peak using to oxygen and carbon emission peaks (related to the breakdown of atmospheric carbon dioxide) constitutes a robust approach. Finally, moreover, the calibration curve obtained is relatively independent of the samples types.« less

Quantification of water content by laser induced breakdown spectroscopy on Mars

DOE PAGES

Rapin, W.; Meslin, P. -Y.; Maurice, S.; ...

2017-02-12

Laser induced breakdown spectroscopy (LIBS), as performed by the ChemCam instrument, provides a new technique to measure hydrogen at the surface of Mars. Using a laboratory replica of the LIBS instrument onboard the Curiosity rover, different types of hydrated samples (basalts, calcium and magnesium sulfates, opals and apatites) covering a range of targets observed on Mars have been characterized and analyzed in this paper. A number of factors related to laser parameters, atmospheric conditions and differences in targets properties can affect the standoff LIBS signal, and in particular the hydrogen emission peak. Dedicated laboratory tests were run to identify amore » normalization of the hydrogen signal which could best compensate for these effects and enable the application of the laboratory calibration to Mars data. We check that the hydrogen signal increases linearly with water content; and normalization of the hydrogen emission peak using to oxygen and carbon emission peaks (related to the breakdown of atmospheric carbon dioxide) constitutes a robust approach. Finally, moreover, the calibration curve obtained is relatively independent of the samples types.« less

Adaptive thresholding with inverted triangular area for real-time detection of the heart rate from photoplethysmogram traces on a smartphone.

PubMed

Jiang, Wen Jun; Wittek, Peter; Zhao, Li; Gao, Shi Chao

2014-01-01

Photoplethysmogram (PPG) signals acquired by smartphone cameras are weaker than those acquired by dedicated pulse oximeters. Furthermore, the signals have lower sampling rates, have notches in the waveform and are more severely affected by baseline drift, leading to specific morphological characteristics. This paper introduces a new feature, the inverted triangular area, to address these specific characteristics. The new feature enables real-time adaptive waveform detection using an algorithm of linear time complexity. It can also recognize notches in the waveform and it is inherently robust to baseline drift. An implementation of the algorithm on Android is available for free download. We collected data from 24 volunteers and compared our algorithm in peak detection with two competing algorithms designed for PPG signals, Incremental-Merge Segmentation (IMS) and Adaptive Thresholding (ADT). A sensitivity of 98.0% and a positive predictive value of 98.8% were obtained, which were 7.7% higher than the IMS algorithm in sensitivity, and 8.3% higher than the ADT algorithm in positive predictive value. The experimental results confirmed the applicability of the proposed method.

FPGA-based architecture for real-time data reduction of ultrasound signals.

PubMed

Soto-Cajiga, J A; Pedraza-Ortega, J C; Rubio-Gonzalez, C; Bandala-Sanchez, M; Romero-Troncoso, R de J

2012-02-01

This paper describes a novel method for on-line real-time data reduction of radiofrequency (RF) ultrasound signals. The approach is based on a field programmable gate array (FPGA) system intended mainly for steel thickness measurements. Ultrasound data reduction is desirable when: (1) direct measurements performed by an operator are not accessible; (2) it is required to store a considerable amount of data; (3) the application requires measuring at very high speeds; and (4) the physical space for the embedded hardware is limited. All the aforementioned scenarios can be present in applications such as pipeline inspection where data reduction is traditionally performed on-line using pipeline inspection gauges (PIG). The method proposed in this work consists of identifying and storing in real-time only the time of occurrence (TOO) and the maximum amplitude of each echo present in a given RF ultrasound signal. The method is tested with a dedicated immersion system where a significant data reduction with an average of 96.5% is achieved. Copyright © 2011 Elsevier B.V. All rights reserved.

PREDICTS

NASA Technical Reports Server (NTRS)

Zhou, Hanying

2007-01-01

PREDICTS is a computer program that predicts the frequencies, as functions of time, of signals to be received by a radio science receiver in this case, a special-purpose digital receiver dedicated to analysis of signals received by an antenna in NASA s Deep Space Network (DSN). Unlike other software used in the DSN, PREDICTS does not use interpolation early in the calculations; as a consequence, PREDICTS is more precise and more stable. The precision afforded by the other DSN software is sufficient for telemetry; the greater precision afforded by PREDICTS is needed for radio-science experiments. In addition to frequencies as a function of time, PREDICTS yields the rates of change and interpolation coefficients for the frequencies and the beginning and ending times of reception, transmission, and occultation. PREDICTS is applicable to S-, X-, and Ka-band signals and can accommodate the following link configurations: (1) one-way (spacecraft to ground), (2) two-way (from a ground station to a spacecraft to the same ground station), and (3) three-way (from a ground transmitting station to a spacecraft to a different ground receiving station).

Supernova Neutrino Physics with Xenon Dark Matter Detectors

NASA Astrophysics Data System (ADS)

Reichard, Shayne; Lang, Rafael F.; McCabe, Christopher; Selvi, Marco; Tamborra, Irene

2017-09-01

The dark matter experiment XENON1T is operational and sensitive to all flavors of neutrinos emitted from a supernova. We show that the proportional scintillation signal (S2) allows for a clear observation of the neutrino signal and guarantees a particularly low energy threshold, while the backgrounds are rendered negligible during the SN burst. XENON1T (XENONnT and LZ; DARWIN) will be sensitive to a SN burst up to 25 (40; 70) kpc from Earth at a significance of more than 5σ, observing approximately 35 (123; 704) events from a 27 M ⊙ SN progenitor at 10 kpc. Moreover, it will be possible to measure the average neutrino energy of all flavors, to constrain the total explosion energy, and to reconstruct the SN neutrino light curve. Our results suggest that a large xenon detector such as DARWIN will be competitive with dedicated neutrino telescopes, while providing complementary information that is not otherwise accessible.

4 Gbps Scalable Low-Voltage Signaling (SLVS) transceiver for pixel radiation detectors

NASA Astrophysics Data System (ADS)

Kadlubowski, Lukasz A.; Kmon, Piotr

2017-08-01

We report on the design of 4 Gbps Scalable Low-Voltage Signaling (SLVS) transceiver in 40nm CMOS technology for application-specific integrated circuits (ASICs) dedicated to pixel radiation detectors. Serial data are transmitted with +/-200mV differential swing around 200mV nominal common-mode level. The common-mode interference minimization is crucial in such a design, due to EMC requirements. For multi-gigabit-per-second speeds, the influence of power supply path becomes one of the most challenging design issues. Accurate modeling of supply pads at each step of the design is necessary. Our analysis shows that the utilization of multiple bond wires as well as separate power supply pads for bulk terminals connection of the transistors is essential to ensure proper operation of the transceiver. The design is a result of various trade-offs between speed, required operating conditions, common-mode interference as well as power and area consumption.

Stand-Alone and Hybrid Positioning Using Asynchronous Pseudolites

PubMed Central

Gioia, Ciro; Borio, Daniele

2015-01-01

global navigation satellite system (GNSS) receivers are usually unable to achieve satisfactory performance in difficult environments, such as open-pit mines, urban canyons and indoors. Pseudolites have the potential to extend GNSS usage and significantly improve receiver performance in such environments by providing additional navigation signals. This also applies to asynchronous pseudolite systems, where different pseudolites operate in an independent way. Asynchronous pseudolite systems require, however, dedicated strategies in order to properly integrate GNSS and pseudolite measurements. In this paper, several asynchronous pseudolite/GNSS integration strategies are considered: loosely- and tightly-coupled approaches are developed and combined with pseudolite proximity and receiver signal strength (RSS)-based positioning. The performance of the approaches proposed has been tested in different scenarios, including static and kinematic conditions. The tests performed demonstrate that the methods developed are effective techniques for integrating heterogeneous measurements from different sources, such as asynchronous pseudolites and GNSS. PMID:25609041

Trends in communicative access solutions for children with cerebral palsy.

PubMed

Myrden, Andrew; Schudlo, Larissa; Weyand, Sabine; Zeyl, Timothy; Chau, Tom

2014-08-01

Access solutions may facilitate communication in children with limited functional speech and motor control. This study reviews current trends in access solution development for children with cerebral palsy, with particular emphasis on the access technology that harnesses a control signal from the user (eg, movement or physiological change) and the output device (eg, augmentative and alternative communication system) whose behavior is modulated by the user's control signal. Access technologies have advanced from simple mechanical switches to machine vision (eg, eye-gaze trackers), inertial sensing, and emerging physiological interfaces that require minimal physical effort. Similarly, output devices have evolved from bulky, dedicated hardware with limited configurability, to platform-agnostic, highly personalized mobile applications. Emerging case studies encourage the consideration of access technology for all nonverbal children with cerebral palsy with at least nascent contingency awareness. However, establishing robust evidence of the effectiveness of the aforementioned advances will require more expansive studies. © The Author(s) 2014.

MuTRiG: a mixed signal Silicon Photomultiplier readout ASIC with high timing resolution and gigabit data link

NASA Astrophysics Data System (ADS)

Chen, H.; Briggl, K.; Eckert, P.; Harion, T.; Munwes, Y.; Shen, W.; Stankova, V.; Schultz-Coulon, H. C.

2017-01-01

MuTRiG is a mixed signal Silicon Photomultiplier readout ASIC designed in UMC 180 nm CMOS technology for precise timing and high event rate applications in high energy physics experiments and medical imaging. It is dedicated to the readout of the scintillating fiber detector and the scintillating tile detector of the Mu3e experiment. The MuTRiG chip extends the excellent timing performance of the STiCv3 chip with a fast digital readout for high rate applications. The high timing performance of the fully differential SiPM readout channels and 50 ps time binning TDCs are complemented by an upgraded digital readout logic and a 1.28 Gbps LVDS serial data link. The design of the chip and the characterization results of the analog front-end, TDC and the LVDS data link are presented.

A proposal for a drug product Manufacturing Classification System (MCS) for oral solid dosage forms.

PubMed

Leane, Michael; Pitt, Kendal; Reynolds, Gavin

2015-01-01

This paper proposes the development of a drug product Manufacturing Classification System (MCS) based on processing route. It summarizes conclusions from a dedicated APS conference and subsequent discussion within APS focus groups and the MCS working party. The MCS is intended as a tool for pharmaceutical scientists to rank the feasibility of different processing routes for the manufacture of oral solid dosage forms, based on selected properties of the API and the needs of the formulation. It has many applications in pharmaceutical development, in particular, it will provide a common understanding of risk by defining what the "right particles" are, enable the selection of the best process, and aid subsequent transfer to manufacturing. The ultimate aim is one of prediction of product developability and processability based upon previous experience. This paper is intended to stimulate contribution from a broad range of stakeholders to develop the MCS concept further and apply it to practice. In particular, opinions are sought on what API properties are important when selecting or modifying materials to enable an efficient and robust pharmaceutical manufacturing process. Feedback can be given by replying to our dedicated e-mail address (mcs@apsgb.org); completing the survey on our LinkedIn site; or by attending one of our planned conference roundtable sessions.

Performance study of SKIROC2/A ASIC for ILD Si-W ECAL

NASA Astrophysics Data System (ADS)

Suehara, T.; Sekiya, I.; Callier, S.; Balagura, V.; Boudry, V.; Brient, J.-C.; de la Taille, C.; Kawagoe, K.; Irles, A.; Magniette, F.; Nanni, J.; Pöschl, R.; Yoshioka, T.

2018-03-01

The ILD Si-W ECAL is a sampling calorimeter with tungsten absorber and highly segmented silicon layers for the International Large Detector (ILD), one of the two detector concepts for the International Linear Collider. SKIROC2 is an ASIC for the ILD Si-W ECAL. To investigate the issues found in prototype detectors, we prepared dedicated ASIC evaluation boards with either BGA sockets or directly soldered SKIROC2. We report a performance study with the evaluation boards, including signal-to-noise ratio and TDC performance with comparing SKIROC2 and an updated version, SKIROC2A.

Project MINERVA's Follow-up on Wide-Field, Small Telescope Photometry to Identify Exoplanets

NASA Astrophysics Data System (ADS)

Houghton, Audrey; Henderson, Morgan; Johnson, Samson; Sergi, Anthony; Eastman, Jason D.; Beatty, Thomas G.; McCrady, Nate

2017-01-01

MINERVA is an array of four 0.7-m telescopes equipped for high precision photometry and spectroscopy dedicated to exoplanet observations. During the first 18 months of science operations, MINERVA engaged in a program of photometric follow-up of potential transiting exoplanet targets identified by the Kilodegree Extremely Little Telescope (KELT). Robotically-obtained observations are passed through our data reduction pipeline and we extract light curves via differential photometry. We seek transit signals via a Markov chain Monte Carlo fit using BATMAN. We discuss results for over 100 target stars analyzed to date.

Processor Would Find Best Paths On Map

NASA Technical Reports Server (NTRS)

Eberhardt, Silvio P.

1990-01-01

Proposed very-large-scale integrated (VLSI) circuit image-data processor finds path of least cost from specified origin to any destination on map. Cost of traversal assigned to each picture element of map. Path of least cost from originating picture element to every other picture element computed as path that preserves as much as possible of signal transmitted by originating picture element. Dedicated microprocessor at each picture element stores cost of traversal and performs its share of computations of paths of least cost. Least-cost-path problem occurs in research, military maneuvers, and in planning routes of vehicles.

A Two-Layers Based Approach of an Enhanced-Map for Urban Positioning Support

PubMed Central

Piñana-Díaz, Carolina; Toledo-Moreo, Rafael; Toledo-Moreo, F. Javier; Skarmeta, Antonio

2012-01-01

This paper presents a two-layer based enhanced map that can support navigation in urban environments. One layer is dedicated to describe the drivable road with a special focus on the accurate description of its bounds. This feature can support positioning and advanced map-matching when compared with standard polyline-based maps. The other layer depicts building heights and locations, thus enabling the detection of non-line-of-sight signals coming from GPS satellites not in direct view. Both the concept and the methodology for creating these enhanced maps are shown in the paper. PMID:23202172

Development of clinical contents model markup language for electronic health records.

PubMed

Yun, Ji-Hyun; Ahn, Sun-Ju; Kim, Yoon

2012-09-01

To develop dedicated markup language for clinical contents models (CCM) to facilitate the active use of CCM in electronic health record systems. Based on analysis of the structure and characteristics of CCM in the clinical domain, we designed extensible markup language (XML) based CCM markup language (CCML) schema manually. CCML faithfully reflects CCM in both the syntactic and semantic aspects. As this language is based on XML, it can be expressed and processed in computer systems and can be used in a technology-neutral way. CCML HAS THE FOLLOWING STRENGTHS: it is machine-readable and highly human-readable, it does not require a dedicated parser, and it can be applied for existing electronic health record systems.

Applications of sonochemistry in Russian food processing industry.

PubMed

Krasulya, Olga; Shestakov, Sergey; Bogush, Vladimir; Potoroko, Irina; Cherepanov, Pavel; Krasulya, Boris

2014-11-01

In food industry, conventional methodologies such as grinding, mixing, and heat treatment are used for food processing and preservation. These processes have been well studied for many centuries and used in the conversion of raw food materials to consumable food products. This report is dedicated to the application of a cost-efficient method of energy transfer caused by acoustic cavitation effects in food processing, overall, having significant impacts on the development of relatively new area of food processing such as food sonochemistry. Copyright © 2014 Elsevier B.V. All rights reserved.

Process Based on SysML for New Launchers System and Software Developments

NASA Astrophysics Data System (ADS)

Hiron, Emmanuel; Miramont, Philippe

2010-08-01

The purpose of this paper is to present the Astrium-ST engineering process based on SysML. This process is currently set-up in the frame of common CNES /Astrium-ST R&T studies related to the Ariane 5 electrical system and flight software modelling. The tool used to set up this process is Rhapsody release 7.3 from IBM-Software firm [1]. This process focuses on the system engineering phase dedicated to Software with the objective to generate both System documents (sequential system design and flight control) and Software specifications.

Derivation of a respiration trigger signal in small animal list-mode PET based on respiration-induced variations of the ECG signal.

PubMed

Todica, Andrei; Lehner, Sebastian; Wang, Hao; Zacherl, Mathias J; Nekolla, Katharina; Mille, Erik; Xiong, Guoming; Bartenstein, Peter; la Fougère, Christian; Hacker, Marcus; Böning, Guido

2016-02-01

Raw PET list-mode data contains motion artifacts causing image blurring and decreased spatial resolution. Unless corrected, this leads to underestimation of the tracer uptake and overestimation of the lesion size, as well as inaccuracies with regard to left ventricular volume and ejection fraction (LVEF), especially in small animal imaging. A respiratory trigger signal from respiration-induced variations in the electro-cardiogram (ECG) was detected. Original and revised list-mode PET data were used for calculation of left ventricular function parameters using both respiratory gating techniques. For adequately triggered datasets we saw no difference in mean respiratory cycle period between the reference standard (RRS) and the ECG-based (ERS) methods (1120 ± 159 ms vs 1120 ± 159 ms; P = n.s.). While the ECG-based method showed somewhat higher signal noise (66 ± 22 ms vs 51 ± 29 ms; P < .001), both respiratory triggering techniques yielded similar estimates for EDV, ESV, LVEF (RRS: 387 ± 56 µL, 162 ± 34 µL, 59 ± 5%; ERS: 389 ± 59 µL, 163 ± 35 µL, 59 ± 4%; P = n.s.). This study showed that respiratory gating signals can be accurately derived from cardiac trigger information alone, without the additional requirement for dedicated measurement of the respiratory motion in rats.

SEMICONDUCTOR TECHNOLOGY A signal processing method for the friction-based endpoint detection system of a CMP process

NASA Astrophysics Data System (ADS)

Chi, Xu; Dongming, Guo; Zhuji, Jin; Renke, Kang

2010-12-01

A signal processing method for the friction-based endpoint detection system of a chemical mechanical polishing (CMP) process is presented. The signal process method uses the wavelet threshold denoising method to reduce the noise contained in the measured original signal, extracts the Kalman filter innovation from the denoised signal as the feature signal, and judges the CMP endpoint based on the feature of the Kalman filter innovation sequence during the CMP process. Applying the signal processing method, the endpoint detection experiments of the Cu CMP process were carried out. The results show that the signal processing method can judge the endpoint of the Cu CMP process.

Civil Information and Intelligence Fusion: Making Non-Traditional into New Traditional for the JTF Commander

DTIC Science & Technology

2011-06-22

accessible by intelligence professionals and intelligence organizations frequently do not dedicate enough effort to support the process of...In every theater, Commanders have developed non-doctrinal organizations uniquely suited to their mission in an effort to integrate socio-cultural...information into military decision-making processes. A prime example of a non-traditional organization is the Stability Operations Information

Rapid Presentation of Emotional Expressions Reveals New Emotional Impairments in Tourette’s Syndrome

PubMed Central

Mermillod, Martial; Devaux, Damien; Derost, Philippe; Rieu, Isabelle; Chambres, Patrick; Auxiette, Catherine; Legrand, Guillaume; Galland, Fabienne; Dalens, Hélène; Coulangeon, Louise Marie; Broussolle, Emmanuel; Durif, Franck; Jalenques, Isabelle

2013-01-01

Objective: Based on a variety of empirical evidence obtained within the theoretical framework of embodiment theory, we considered it likely that motor disorders in Tourette’s syndrome (TS) would have emotional consequences for TS patients. However, previous research using emotional facial categorization tasks suggests that these consequences are limited to TS patients with obsessive-compulsive behaviors (OCB). Method: These studies used long stimulus presentations which allowed the participants to categorize the different emotional facial expressions (EFEs) on the basis of a perceptual analysis that might potentially hide a lack of emotional feeling for certain emotions. In order to reduce this perceptual bias, we used a rapid visual presentation procedure. Results: Using this new experimental method, we revealed different and surprising impairments on several EFEs in TS patients compared to matched healthy control participants. Moreover, a spatial frequency analysis of the visual signal processed by the patients suggests that these impairments may be located at a cortical level. Conclusion: The current study indicates that the rapid visual presentation paradigm makes it possible to identify various potential emotional disorders that were not revealed by the standard visual presentation procedures previously reported in the literature. Moreover, the spatial frequency analysis performed in our study suggests that emotional deficit in TS might lie at the level of temporal cortical areas dedicated to the processing of HSF visual information. PMID:23630481

A Prototype PZT Matrix Transducer With Low-Power Integrated Receive ASIC for 3-D Transesophageal Echocardiography.

PubMed

Chen, Chao; Raghunathan, Shreyas B; Yu, Zili; Shabanimotlagh, Maysam; Chen, Zhao; Chang, Zu-yao; Blaak, Sandra; Prins, Christian; Ponte, Jacco; Noothout, Emile; Vos, Hendrik J; Bosch, Johan G; Verweij, Martin D; de Jong, Nico; Pertijs, Michiel A P

2016-01-01

This paper presents the design, fabrication, and experimental evaluation of a prototype lead zirconium titanate (PZT) matrix transducer with an integrated receive ASIC, as a proof of concept for a miniature three-dimensional (3-D) transesophageal echocardiography (TEE) probe. It consists of an array of 9 ×12 piezoelectric elements mounted on the ASIC via an integration scheme that involves direct electrical connections between a bond-pad array on the ASIC and the transducer elements. The ASIC addresses the critical challenge of reducing cable count, and includes front-end amplifiers with adjustable gains and micro-beamformer circuits that locally process and combine echo signals received by the elements of each 3 ×3 subarray. Thus, an order-of-magnitude reduction in the number of receive channels is achieved. Dedicated circuit techniques are employed to meet the strict space and power constraints of TEE probes. The ASIC has been fabricated in a standard 0.18-μm CMOS process and consumes only 0.44 mW/channel. The prototype has been acoustically characterized in a water tank. The ASIC allows the array to be presteered across ±37° while achieving an overall dynamic range of 77 dB. Both the measured characteristics of the individual transducer elements and the performance of the ASIC are in good agreement with expectations, demonstrating the effectiveness of the proposed techniques.

Glacial isostatic adjustment on the Northern Hemisphere - new results from GRACE

NASA Astrophysics Data System (ADS)

Mueller, J.; Steffen, H.; Gitlein, O.; Denker, H.; Timmen, L.

2007-12-01

The Earth's gravity field mapped by the Gravity Recovery and Climate Experiment (GRACE) satellite mission shows variations due to the integral effect of mass variations in the atmosphere, hydrosphere and geosphere. The Earth's gravity field is provided in form of monthly solutions by several institutions, e.~g. GFZ Potsdam, CSR and JPL. During the GRACE standard processing of these analysis centers, oceanic and atmospheric contributions as well as tidal effects are reduced. The solutions of the analysis centers differ slightly, which is due the application of different reduction models and center-specific processing schemes. We present our investigation of mass variations in the areas of glacial isostatic adjustment (GIA) in North America and Northern Europe from GRACE data. One key issue is the separation of GIA parts and the reduction of the observed quantities by applying dedicated filters (e.~g. isotropic, non-isotropic, and destriping filters) and global models of hydrological variations (e.~g. WGHM, LaDWorld, GLDAS). In a further step, we analyze the results of both regions regarding their reliability, and finally present a comparison to results of a geodynamical modeling and absolute gravity measurements. Our results clearly show that the quality of the GRACE-derived gravity- change signal benefits from improved reduction models and chosen analysis techniques. Nevertheless, the comparison to results of geodynamic models still reveals differences, and thus further studies are in progress.

Design considerations for a C-shaped PET system, dedicated to small animal brain imaging, using GATE Monte Carlo simulations

NASA Astrophysics Data System (ADS)

Efthimiou, N.; Papadimitroulas, P.; Kostou, T.; Loudos, G.

2015-09-01

Commercial clinical and preclinical PET scanners rely on the full cylindrical geometry for whole body scans as well as for dedicated organs. In this study we propose the construction of a low cost dual-head C-shaped PET system dedicated for small animal brain imaging. Monte Carlo simulation studies were performed using GATE toolkit to evaluate the optimum design in terms of sensitivity, distortions in the FOV and spatial resolution. The PET model is based on SiPMs and BGO pixelated arrays. Four different configurations with C- angle 0°, 15°, 30° and 45° within the modules, were considered. Geometrical phantoms were used for the evaluation process. STIR software, extended by an efficient multi-threaded ray tracing technique, was used for the image reconstruction. The algorithm automatically adjusts the size of the FOV according to the shape of the detector's geometry. The results showed improvement in sensitivity of ∼15% in case of 45° C-angle compared to the 0° case. The spatial resolution was found 2 mm for 45° C-angle.

CHARACTERIZING THE ATMOSPHERES OF TRANSITING PLANETS WITH A DEDICATED SPACE TELESCOPE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tessenyi, M.; Tinetti, G.; Swinyard, B.

Exoplanetary science is one of the fastest evolving fields of today's astronomical research, continuously yielding unexpected and surprising results. Ground-based planet-hunting surveys, together with dedicated space missions such as Kepler and CoRoT, are delivering an ever-increasing number of exoplanets, over 690, and ESA's Gaia mission will escalate the exoplanetary census into the several thousands. The next logical step is the characterization of these new worlds. What is their nature? Why are they as they are? Use of the Hubble Space Telescope and Spitzer Space Telescope to probe the atmospheres of transiting hot, gaseous exoplanets has opened perspectives unimaginable even justmore » 10 years ago, demonstrating that it is indeed possible with current technology to address the ambitious goal of characterizing the atmospheres of these alien worlds. However, these successful measurements have also shown the difficulty of understanding the physics and chemistry of these exotic environments when having to rely on a limited number of observations performed on a handful of objects. To progress substantially in this field, a dedicated facility for exoplanet characterization, able to observe a statistically significant number of planets over time and a broad spectral range will be essential. Additionally, the instrument design (e.g., detector performances, photometric stability) will be tailored to optimize the extraction of the astrophysical signal. In this paper, we analyze the performance and tradeoffs of a 1.2/1.4 m space telescope for exoplanet transit spectroscopy from the visible to the mid-IR. We present the signal-to-noise ratio as a function of integration time and stellar magnitude/spectral type for the acquisition of spectra of planetary atmospheres for a variety of scenarios: hot, warm, and temperate planets orbiting stars ranging in spectral type from hot F- to cooler M-dwarfs. Our results include key examples of known planets (e.g., HD 189733b, GJ 436b, GJ 1214b, and Cancri 55 e) and simulations of plausible terrestrial and gaseous planets, with a variety of thermodynamical conditions. We conclude that even most challenging targets, such as super-Earths in the habitable zone of late-type stars, are within reach of an M-class, space-based spectroscopy mission.« less

vMon-mobile provides wireless connection to the electronic patient record

NASA Astrophysics Data System (ADS)

Oliveira, Pedro P., Jr.; Rebelo, Marina; Pilon, Paulo E.; Gutierrez, Marco A.; Tachinardi, Umberto

2002-05-01

This work presents the development of a set of tools to help doctors to continuously monitor critical patients. Real-time monitoring signals are displayed via a Web Based Electronic Patient Record (Web-EPR) developed at the Heart Institute. Any computer on the Hospital's Intranet can access the Web-EPR that will open a browser plug-in called vMon. Recently vMon was adapted to wireless mobile devices providing the same real-time visualization of vital signals of its desktop counterpart. The monitoring network communicates with the hospital network through a gateway using HL7 messages and has the ability to export waveforms in real time using the multicast protocol through an API library. A dedicated ActiveX component was built that establishes the streaming of the biomedical signals under monitoring and displays them on an Internet Explorer 5.x browser. The mobile version - called vMon-mobile - will parse the browser window and deliver it to a PDA device connected to a local area network. The result is a virtual monitor presenting real-time data on a mobile device. All parameters and signals acquired from the moment the patient is connected to the monitors are stored for a few days. The most clinically relevant information is added to patient's EPR.

New Strategy of the Distance Education

ERIC Educational Resources Information Center

Bunyatova, Fatma Khanim; Salamov, Gulbala

2014-01-01

This article is dedicated to new strategy of distance education. The article deals with the possibilities of ICT (Information and Communication Technologies) in teaching specially distance education. In the article, ICT technological tools and their methods of application in educational process are looked over; discrepancy of intellectual…

Reflections on Language Learning.

ERIC Educational Resources Information Center

Barbara, Leila, Ed.; Scott, Mike, Ed.

The collection of papers, dedicated to Maria Antonieta Alba Celani, a celebrated English professor in Brazil, consists of writings by colleagues on four themes: developments stemming from Dr. Celani's Brazilian national project for the teaching of English for special purposes; language teacher training; language processing; and analysis of…

TECHNOLOGY AND MANPOWER IN THE TELEPHONE INDUSTRY, 1965-75.

ERIC Educational Resources Information Center

LUSKIN, SHELDON H.; AND OTHERS

ELECTRONIC SOLID STATE SWITCHING SYSTEMS, COMMUNICATIONS SATELLITES, SEMIAUTOMATIC INFORMATION SERVICES, AUTOMATIC INTERCEPTING AND DATA PROCESSING, AND DEDICATED PLANT, THE PERMANENT ASSIGNMENT OF LINES FROM A CENTRAL OFFICE TO EACH ACTUAL AND POTENTIAL SUBSCRIBER, ARE SOME OF THE TECHNOLOGICAL INNOVATIONS WHICH WILL BRING SIGNIFICANT MANPOWER…

A Community of Practice: Web Portals and Faculty Development.

ERIC Educational Resources Information Center

Carlson, Patricia A.

2002-01-01

Describes a Web portal constructed by Rose-Hulman Institute of Technology dedicated to improving middle school science, mathematics, and technology instruction. The portal emulates emerging corporate practices of knowledge management and process reinvention through information technology, and offers middle school teachers across Indiana a…

Determining the maintenance superintendent and facility needs for residencies in the Virginia Department of Transportation.

DOT National Transportation Integrated Search

2010-06-01

In the spring of 2007, the Virginia Department of Transportation (VDOT) began the process of reducing the number of superintendents and facilities dedicated to ordinary maintenance tasks. The need to downsize was the direct result of the requirement ...

American Pastured Poultry Producers Association (APPPA) Perspective of Alternative Poultry Production Practices

USDA-ARS?s Scientific Manuscript database

The American Pastured Poultry Producers Association (APPPA) is a nonprofit educational and networking organization dedicated to encouraging the production, processing, and marketing of poultry raised on pasture, and is the largest industry group focused on pastured poultry. APPPA passionately embr...

The anomaly data base of screwworm information

NASA Technical Reports Server (NTRS)

Giddings, L. E.

1976-01-01

Standard statistical processing of anomaly data in the screwworm eradication data system is possible from data compiled on magnetic tapes with the Univac 1108 computer. The format and organization of the data in the data base, which is also available on dedicated disc storage, are described.

APEX - the Hyperspectral ESA Airborne Prism Experiment

PubMed Central

Itten, Klaus I.; Dell'Endice, Francesco; Hueni, Andreas; Kneubühler, Mathias; Schläpfer, Daniel; Odermatt, Daniel; Seidel, Felix; Huber, Silvia; Schopfer, Jürg; Kellenberger, Tobias; Bühler, Yves; D'Odorico, Petra; Nieke, Jens; Alberti, Edoardo; Meuleman, Koen

2008-01-01

The airborne ESA-APEX (Airborne Prism Experiment) hyperspectral mission simulator is described with its distinct specifications to provide high quality remote sensing data. The concept of an automatic calibration, performed in the Calibration Home Base (CHB) by using the Control Test Master (CTM), the In-Flight Calibration facility (IFC), quality flagging (QF) and specific processing in a dedicated Processing and Archiving Facility (PAF), and vicarious calibration experiments are presented. A preview on major applications and the corresponding development efforts to provide scientific data products up to level 2/3 to the user is presented for limnology, vegetation, aerosols, general classification routines and rapid mapping tasks. BRDF (Bidirectional Reflectance Distribution Function) issues are discussed and the spectral database SPECCHIO (Spectral Input/Output) introduced. The optical performance as well as the dedicated software utilities make APEX a state-of-the-art hyperspectral sensor, capable of (a) satisfying the needs of several research communities and (b) helping the understanding of the Earth's complex mechanisms. PMID:27873868

Clay-cement suspensions - rheological and functional properties

NASA Astrophysics Data System (ADS)

Wojcik, L.; Izak, P.; Mastalska-Poplawska, J.; Gajek, M.

2017-01-01

The piping erosion in soil is highly unexpected in civil engineering. Elimination of such damages is difficult, expensive and time-consuming. One of the possibility is the grouting method. This method is still developed into direction of process automation as well as other useful properties of suspensions. Main way of modernization of the grouting method is connected it with rheology of injection and eventuality of fitting them to specific problems conditions. Very popular and useful became binders based on modified clays (clay-cement suspensions). Important principle of efficiency of the grouting method is using of time-dependent pseudothixotropic properties of the clay-cement suspensions. The pseudo-rheounstability aspect of the suspensions properties should be dedicated and fitted to dynamic changes of soil conditions destructions. Whole process of the modification of the suspension rheology is stimulated by the specific agents. This article contains a description of practical aspects of the rheological parameters managing of the clay-cement suspensions, dedicated to the building damages, hydrotechnic constructions etc.

Instrumentation and control system architecture of ECRH SST1

NASA Astrophysics Data System (ADS)

Patel, Harshida; Patel, Jatin; purohit, Dharmesh; Shukla, B. K.; Babu, Rajan; Mistry, Hardik

2017-07-01

The Electron Cyclotron Resonance Heating (ECRH) system is an important heating system for the reliable start-up of tokamak. The 42GHz and 82.6GHz Gyrotron based ECRH systems are used in tokomaks SST-1 and Aditya to carry out ECRH related experiments. The Gyrotrons are high power microwave tubes used as a source for ECRH systems. The Gyrotrons need to be handled with optimum care right from the installation to its Full parameter control operation. The Gyrotrons are associated with the subsystems like: High voltage power supplies (Beam voltage and anode voltage), dedicated crowbar system, magnet, filament and ion pump power supplies and cooling system. The other subsystems are transmission line, launcher and dummy load. A dedicated VME based data acquisition & control (DAC) system is developed to operate and control the Gyrotron and its associated sub system. For the safe operation of Gyrotron, two level interlocks with fail-safe logic are developed. Slow signals that are operated in scale of millisecond range are programmed through software and hardware interlock in scale of microsecond range are designed and developed indigenously. Water-cooling and the associated interlock are monitored and control by data logger with independent human machine interface.

All-digital multicarrier demodulators for on-board processing satellites in mobile communication systems

NASA Astrophysics Data System (ADS)

Yim, Wan Hung

Economical operation of future satellite systems for mobile communications can only be fulfilled by using dedicated on-board processing satellites, which would allow both cheap earth terminals and lower space segment costs. With on-board modems and codecs, the up-link and down-link can be optimized separately. An attractive scheme is to use frequency-division multiple access/single chanel per carrier (FDMA/SCPC) on the up-link and time division multiplexing (TDM) on the down-link. This scheme allows mobile terminals to transmit a narrow band, low power signal, resulting in smaller dishes and high power amplifiers (HPA's) with lower output power. On the up-link, there are hundreds to thousands of FDM channels to be demodulated on-board. The most promising approach is the use of all-digital multicarrier demodulators (MCD's), where analog and digital hardware are efficiently shared among channels, and digital signal processing (DSP) is used at an early stage to take advantage of very large scale integration (VLSI) implementation. A MCD consists of a channellizer for separation of frequency division multiplexing (FDM) channels, followed by individual modulators for each channel. Major research areas in MCD's are in multirate DSP, and the optimal estimation for synchronization, which form the basis of the thesis. Complex signal theories are central to the development of structured approaches for the sampling and processing of bandpass signals, which are the foundations in both channellizer and demodulator design. In multirate DSP, polyphase theories replace many ad-hoc, tedious and error-prone design procedures. For example, a polyphase-matrix deep space network frequency and timing system (DFT) channellizer includes all efficient filter bank techniques as special cases. Also, a polyphase-lattice filter is derived, not only for sampling rate conversion, but also capable of sampling phase variation, which is required for symbol timing adjustment in all-digital demodulators. In modulation schemes, a systematic survey is reported, based on two expressions that includes all formats in linear and constant envelope modulation. In synchronization techniques, classifications according to the criterion of statistical optimization, the data dependecy, and the method of parameter extraction, reflect the inherent complexity and performance of numerous existing algorithms. The designs of two new algorithms are presented: a differential decision frequency error detector that is simple and fast; a dual-comb-filter frequency/timing error detector that is targeted at VLSI implementation. The real-time implementation of a complete 4 x 16 kb/s MCD for the T-SAT project is described in detail, which proved many of the structured design concepts developed in this thesis. The requirements of software tools for various levels of simulation in multirate DSP and communications are analyzed. This led to the implementation of a data-flow oriented simulation system, which was used in all research work in the thesis.

Real Time Target Tracking Using Dedicated Vision Hardware

NASA Astrophysics Data System (ADS)

Kambies, Keith; Walsh, Peter

1988-03-01

This paper describes a real-time vision target tracking system developed by Adaptive Automation, Inc. and delivered to NASA's Launch Equipment Test Facility, Kennedy Space Center, Florida. The target tracking system is part of the Robotic Application Development Laboratory (RADL) which was designed to provide NASA with a general purpose robotic research and development test bed for the integration of robot and sensor systems. One of the first RADL system applications is the closing of a position control loop around a six-axis articulated arm industrial robot using a camera and dedicated vision processor as the input sensor so that the robot can locate and track a moving target. The vision system is inside of the loop closure of the robot tracking system, therefore, tight throughput and latency constraints are imposed on the vision system that can only be met with specialized hardware and a concurrent approach to the processing algorithms. State of the art VME based vision boards capable of processing the image at frame rates were used with a real-time, multi-tasking operating system to achieve the performance required. This paper describes the high speed vision based tracking task, the system throughput requirements, the use of dedicated vision hardware architecture, and the implementation design details. Important to the overall philosophy of the complete system was the hierarchical and modular approach applied to all aspects of the system, hardware and software alike, so there is special emphasis placed on this topic in the paper.

Variational Assimilation of Sparse and Uncertain Satellite Data For 1D Saint-Venant River Models

NASA Astrophysics Data System (ADS)

Garambois, P. A.; Brisset, P.; Monnier, J.; Roux, H.

2016-12-01

Profusion of satellites are providing increasingly accurate measurements of continental water cyle, and water bodies variations while in situ observability is declining. The future Surface Water and Ocean Topography (SWOT) mission will provide maps of river surface elevations widths and slopes with an almost global coverage and temporal revisits. This will offer the possibility to address a larger variety of inverse problems in surface hydrology. Data assimilation techniques, that are broadly used in several scientific fields, aim to optimally combine models, system observations and prior information. Variational assimilation consists in iterative minimization of a discrepency measure between model outputs and observations, here for retrieving boundary conditions and parameters of a 1D Saint Venant model. Nevertheless, inferring river discharge and hydraulic parameters thanks to the observation of river surface is not straightforward. This is particularly true in the case of sparse and uncertain observations of flow state variables since they are governed by nonlinear physical processes. This paper investigates the identifiability of hydraulic controls given sparse and uncertain satellite observations of a river. The identifiability of river discharge alone and with roughness is tested for several spatio temporal patterns of river observations, including SWOT like observations. A new 1D Shallow water model with variational data assimilation, within the DassFlow chain is presented as well as postprocessing and observation operator dedicated to the future SWOT and SWOT simulator data. In view to decrease inverse problem dimensionality discharge is represented in a reduced basis. Moreover we introduce an original and reduced parametrization of the flow resistance that can account for various flow regimes along with a cross section design dedicated to remote sensing. We show which discharge temporal frequencies can be identified w.r.t observation ones and at which accuracy. Eventually the important question of the discharge identifiability potential between observation times and depending on the spatio-temporal sampling is adressed with respect to the wave lengths of the hydrological signals.

Characterization and commissioning of the SST-1M camera for the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Aguilar, J. A.; Bilnik, W.; Błocki, J.; Bogacz, L.; Borkowski, J.; Bulik, T.; Cadoux, F.; Christov, A.; Curyło, M.; della Volpe, D.; Dyrda, M.; Favre, Y.; Frankowski, A.; Grudnik, Ł.; Grudzińska, M.; Heller, M.; Idźkowski, B.; Jamrozy, M.; Janiak, M.; Kasperek, J.; Lalik, K.; Lyard, E.; Mach, E.; Mandat, D.; Marszałek, A.; Medina Miranda, L. D.; Michałowski, J.; Moderski, R.; Montaruli, T.; Neronov, A.; Niemiec, J.; Ostrowski, M.; Paśko, P.; Pech, M.; Porcelli, A.; Prandini, E.; Rajda, P.; Rameez, M.; Schioppa, E., Jr.; Schovanek, P.; Seweryn, K.; Skowron, K.; Sliusar, V.; Sowiński, M.; Stawarz, Ł.; Stodulska, M.; Stodulski, M.; Toscano, S.; Troyano Pujadas, I.; Walter, R.; Wiȩcek, M.; Zagdański, A.; Ziȩtara, K.; Żychowski, P.

2017-02-01

The Cherenkov Telescope Array (CTA), the next generation very high energy gamma-rays observatory, will consist of three types of telescopes: large (LST), medium (MST) and small (SST) size telescopes. The SSTs are dedicated to the observation of gamma-rays with energy between a few TeV and a few hundreds of TeV. The SST array is expected to have 70 telescopes of different designs. The single-mirror small size telescope (SST-1 M) is one of the proposed telescope designs under consideration for the SST array. It will be equipped with a 4 m diameter segmented mirror dish and with an innovative camera based on silicon photomultipliers (SiPMs). The challenge is not only to build a telescope with exceptional performance but to do it foreseeing its mass production. To address both of these challenges, the camera adopts innovative solutions both for the optical system and readout. The Photo-Detection Plane (PDP) of the camera is composed of 1296 pixels, each made of a hollow, hexagonal light guide coupled to a hexagonal SiPM designed by the University of Geneva and Hamamatsu. As no commercial ASIC would satisfy the CTA requirements when coupled to such a large sensor, dedicated preamplifier electronics have been designed. The readout electronics also use an innovative approach in gamma-ray astronomy by adopting a fully digital approach. All signals coming from the PDP are digitized in a 250 MHz Fast ADC and stored in ring buffers waiting for a trigger decision to send them to the pre-processing server where calibration and higher level triggers will decide whether the data are stored. The latest generation of FPGAs is used to achieve high data rates and also to exploit all the flexibility of the system. As an example each event can be flagged according to its trigger pattern. All of these features have been demonstrated in laboratory measurements on realistic elements and the results of these measurements will be presented in this contribution.

[Fast determination of induction period of motor gasoline using Fourier transform attenuated total reflection infrared spectroscopy].

PubMed

Liu, Ya-Fei; Yuan, Hong-Fu; Song, Chun-Feng; Xie, Jin-Chun; Li, Xiao-Yu; Yan, De-Lin

2014-11-01

A new method is proposed for the fast determination of the induction period of gasoline using Fourier transform attenuated total reflection infrared spectroscopy (ATR-FTIR). A dedicated analysis system with the function of spectral measurement, data processing, display and storage was designed and integrated using a Fourier transform infrared spectrometer module and chemometric software. The sample presentation accessory designed which has advantages of constant optical path, convenient sample injection and cleaning is composed of a nine times reflection attenuated total reflectance (ATR) crystal of zinc selenide (ZnSe) coated with a diamond film and a stainless steel lid with sealing device. The influence of spectral scanning number and repeated sample loading times on the spectral signal-to-noise ratio was studied. The optimum spectral scanning number is 15 times and the optimum sample loading number is 4 times. Sixty four different gasoline samples were collected from the Beijing-Tianjin area and the induction period values were determined as reference data by standard method GB/T 8018-87. The infrared spectra of these samples were collected in the operating condition mentioned above using the dedicated fast analysis system. Spectra were pretreated using mean centering and 1st derivative to reduce the influence of spectral noise and baseline shift A PLS calibration model for the induction period was established by correlating the known induction period values of the samples with their spectra. The correlation coefficient (R2), standard error of calibration (SEC) and standard error of prediction (SEP) of the model are 0.897, 68.3 and 91.9 minutes, respectively. The relative deviation of the model for gasoline induction period prediction is less than 5%, which meets the requirements of repeatability tolerance in GB method. The new method is simple and fast. It takes no more than 3 minutes to detect one sample. Therefore, the method is feasible for implementing fast determination of gasoline induction period, and of a positive meaning in the evaluation of fuel quality.

Superheavy elements and r-process

NASA Astrophysics Data System (ADS)

Panov, I. V.; Korneev, I. Yu.; Thielemann, F.-K.

2009-06-01

The probability for the production of superheavy elements in the astrophysical r-process is discussed. The dependence of the estimated superheavy-element yields on input data is estimated. Preliminary calculations revealed that the superheavy-element yields at the instant of completion of the r-process may be commensurate with the uranium yield, but the former depend strongly on the models used to forecast the properties of beta-delayed, neutron-induced, and spontaneous fission. This study is dedicated to the 80th anniversary of V.S. Imshennik’s birth.

Development of a mobile system based on laser-induced breakdown spectroscopy and dedicated to in situ analysis of polluted soils

NASA Astrophysics Data System (ADS)

Bousquet, B.; Travaillé, G.; Ismaël, A.; Canioni, L.; Michel-Le Pierrès, K.; Brasseur, E.; Roy, S.; le Hecho, I.; Larregieu, M.; Tellier, S.; Potin-Gautier, M.; Boriachon, T.; Wazen, P.; Diard, A.; Belbèze, S.

2008-10-01

Principal Components Analysis (PCA) is successfully applied to the full laser-induced breakdown spectroscopy (LIBS) spectra of soil samples, defining classes according to the concentrations of the major elements. The large variability of the LIBS data is related to the heterogeneity of the samples and the representativeness of the data is finally discussed. Then, the development of a mobile LIBS system dedicated to the in-situ analysis of soils polluted by heavy metals is described. Based on the use of ten-meter long optical fibers, the mobile system allows deported measurements. Finally, the laser-assisted drying process studied by the use of a customized laser has not been retained to overcome the problem of moisture.

Development of Clinical Contents Model Markup Language for Electronic Health Records

PubMed Central

Yun, Ji-Hyun; Kim, Yoon

2012-01-01

Objectives To develop dedicated markup language for clinical contents models (CCM) to facilitate the active use of CCM in electronic health record systems. Methods Based on analysis of the structure and characteristics of CCM in the clinical domain, we designed extensible markup language (XML) based CCM markup language (CCML) schema manually. Results CCML faithfully reflects CCM in both the syntactic and semantic aspects. As this language is based on XML, it can be expressed and processed in computer systems and can be used in a technology-neutral way. Conclusions CCML has the following strengths: it is machine-readable and highly human-readable, it does not require a dedicated parser, and it can be applied for existing electronic health record systems. PMID:23115739

KSC-2014-4496

NASA Image and Video Library

2014-11-14

CAPE CANAVERAL, Fla. – A plaque affixed to the side of a Magnetospheric Multiscale, or MMS, observatory dedicates the mission to Richard “Richy” D’Antonio, now deceased, in grateful appreciation for his dedicated service to NASA’s MMS mission. MMS, led by a team from NASA's Goddard Space Flight Center, is a Solar Terrestrial Probes mission consisting of four identically instrumented spacecraft that will use Earth’s magnetosphere as a laboratory to study the microphysics of three fundamental plasma processes: magnetic reconnection, energetic particle acceleration and turbulence. Launch aboard a United Launch Alliance Atlas V rocket from Space Launch Complex 41 on Cape Canaveral Air Force Station is targeted for March 12, 2015. To learn more about MMS, visit http://mms.gsfc.nasa.gov. Photo credit: NASA/Kim Shiflett

Quality control for quantitative multicenter whole-body PET/MR studies: A NEMA image quality phantom study with three current PET/MR systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boellaard, Ronald, E-mail: r.boellaard@vumc.nl; European Association of Nuclear Medicine Research Ltd., Vienna 1060; European Association of Nuclear Medicine Physics Committee, Vienna 1060

2015-10-15

Purpose: Integrated positron emission tomography/magnetic resonance (PET/MR) systems derive the PET attenuation correction (AC) from dedicated MR sequences. While MR-AC performs reasonably well in clinical patient imaging, it may fail for phantom-based quality control (QC). The authors assess the applicability of different protocols for PET QC in multicenter PET/MR imaging. Methods: The National Electrical Manufacturers Association NU 2 2007 image quality phantom was imaged on three combined PET/MR systems: a Philips Ingenuity TF PET/MR, a Siemens Biograph mMR, and a GE SIGNA PET/MR (prototype) system. The phantom was filled according to the EANM FDG-PET/CT guideline 1.0 and scanned for 5more » min over 1 bed. Two MR-AC imaging protocols were tested: standard clinical procedures and a dedicated protocol for phantom tests. Depending on the system, the dedicated phantom protocol employs a two-class (water and air) segmentation of the MR data or a CT-based template. Differences in attenuation- and SUV recovery coefficients (RC) are reported. PET/CT-based simulations were performed to simulate the various artifacts seen in the AC maps (μ-map) and their impact on the accuracy of phantom-based QC. Results: Clinical MR-AC protocols caused substantial errors and artifacts in the AC maps, resulting in underestimations of the reconstructed PET activity of up to 27%, depending on the PET/MR system. Using dedicated phantom MR-AC protocols, PET bias was reduced to −8%. Mean and max SUV RC met EARL multicenter PET performance specifications for most contrast objects, but only when using the dedicated phantom protocol. Simulations confirmed the bias in experimental data to be caused by incorrect AC maps resulting from the use of clinical MR-AC protocols. Conclusions: Phantom-based quality control of PET/MR systems in a multicenter, multivendor setting may be performed with sufficient accuracy, but only when dedicated phantom acquisition and processing protocols are used for attenuation correction.« less

Validating and comparing GNSS antenna calibrations

NASA Astrophysics Data System (ADS)

Kallio, Ulla; Koivula, Hannu; Lahtinen, Sonja; Nikkonen, Ville; Poutanen, Markku

2018-03-01

GNSS antennas have no fixed electrical reference point. The variation of the phase centre is modelled and tabulated in antenna calibration tables, which include the offset vector (PCO) and phase centre variation (PCV) for each frequency according to the elevations and azimuths of the incoming signal. Used together, PCV and PCO reduce the phase observations to the antenna reference point. The remaining biases, called the residual offsets, can be revealed by circulating and rotating the antennas on pillars. The residual offsets are estimated as additional parameters when combining the daily GNSS network solutions with full covariance matrix. We present a procedure for validating the antenna calibration tables. The dedicated test field, called Revolver, was constructed at Metsähovi. We used the procedure to validate the calibration tables of 17 antennas. Tables from the IGS and three different calibration institutions were used. The tests show that we were able to separate the residual offsets at the millimetre level. We also investigated the influence of the calibration tables from the different institutions on site coordinates by performing kinematic double-difference baseline processing of the data from one site with different antenna tables. We found small but significant differences between the tables.

Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4

PubMed Central

Haas, Gabrielle; Azevedo, Jacinthe; Moissiard, Guillaume; Geldreich, Angèle; Himber, Christophe; Bureau, Marina; Fukuhara, Toshiyuki; Keller, Mario; Voinnet, Olivier

2008-01-01

Replication of Cauliflower mosaic virus (CaMV), a plant double-stranded DNA virus, requires the viral translational transactivator protein P6. Although P6 is known to form cytoplasmic inclusion bodies (viroplasms) so far considered essential for virus biology, a fraction of the protein is also present in the nucleus. Here, we report that monomeric P6 is imported into the nucleus through two importin-α-dependent nuclear localization signals, and show that this process is mandatory for CaMV infectivity and is independent of translational transactivation and viroplasm formation. One nuclear function of P6 is to suppress RNA silencing, a gene regulation mechanism with antiviral roles, commonly counteracted by dedicated viral suppressor proteins (viral silencing suppressors; VSRs). Transgenic P6 expression in Arabidopsis is genetically equivalent to inactivating the nuclear protein DRB4 that facilitates the activity of the major plant antiviral silencing factor DCL4. We further show that a fraction of P6 immunoprecipitates with DRB4 in CaMV-infected cells. This study identifies both genetic and physical interactions between a VSR to a host RNA silencing component, and highlights the importance of subcellular compartmentalization in VSR function. PMID:18615098

Believing androids - fMRI activation in the right temporo-parietal junction is modulated by ascribing intentions to non-human agents.

PubMed

Özdem, Ceylan; Wiese, Eva; Wykowska, Agnieszka; Müller, Hermann; Brass, Marcel; Van Overwalle, Frank

2017-10-01

Attributing mind to interaction partners has been shown to increase the social relevance we ascribe to others' actions and to modulate the amount of attention dedicated to them. However, it remains unclear how the relationship between higher-order mind attribution and lower-level attention processes is established in the brain. In this neuroimaging study, participants saw images of an anthropomorphic robot that moved its eyes left- or rightwards to signal the appearance of an upcoming stimulus in the same (valid cue) or opposite location (invalid cue). Independently, participants' beliefs about the intentionality underlying the observed eye movements were manipulated by describing the eye movements as under human control or preprogrammed. As expected, we observed a validity effect behaviorally and neurologically (increased response times and activation in the invalid vs. valid condition). More importantly, we observed that this effect was more pronounced for the condition in which the robot's behavior was believed to be controlled by a human, as opposed to be preprogrammed. This interaction effect between cue validity and belief was, however, only found at the neural level and was manifested as a significant increase of activation in bilateral anterior temporoparietal junction.

A wireless body measurement system to study fatigue in multiple sclerosis.

PubMed

Yu, Fei; Bilberg, Arne; Stenager, Egon; Rabotti, Chiara; Zhang, Bin; Mischi, Massimo

2012-12-01

Fatigue is reported as the most common symptom by patients with multiple sclerosis (MS). The physiological and functional parameters related to fatigue in MS patients are currently not well established. A new wearable wireless body measurement system, named Fatigue Monitoring System (FAMOS), was developed to study fatigue in MS. It can continuously measure electrocardiogram, body-skin temperature, electromyogram and motions of feet. The goal of this study is to test the ability of distinguishing fatigued MS patients from healthy subjects by the use of FAMOS. This paper presents the realization of the measurement system including the design of both hardware and dedicated signal processing algorithms. Twenty-six participants including 17 MS patients with fatigue and 9 sex- and age-matched healthy controls were included in the study for continuous 24 h monitoring. The preliminary results show significant differences between fatigued MS patients and healthy controls. In conclusion, the FAMOS enables continuous data acquisition and estimation of multiple physiological and functional parameters. It provides a new, flexible and objective approach to study fatigue in MS, which can distinguish between fatigued MS patients and healthy controls. The usability and reliability of the FAMOS should however be further improved and validated through larger clinical trials.

A computer simulation model to compute the radiation transfer of mountainous regions

NASA Astrophysics Data System (ADS)

Li, Yuguang; Zhao, Feng; Song, Rui

2011-11-01

In mountainous regions, the radiometric signal recorded at the sensor depends on a number of factors such as sun angle, atmospheric conditions, surface cover type, and topography. In this paper, a computer simulation model of radiation transfer is designed and evaluated. This model implements the Monte Carlo ray-tracing techniques and is specifically dedicated to the study of light propagation in mountainous regions. The radiative processes between sun light and the objects within the mountainous region are realized by using forward Monte Carlo ray-tracing methods. The performance of the model is evaluated through detailed comparisons with the well-established 3D computer simulation model: RGM (Radiosity-Graphics combined Model) based on the same scenes and identical spectral parameters, which shows good agreements between these two models' results. By using the newly developed computer model, series of typical mountainous scenes are generated to analyze the physical mechanism of mountainous radiation transfer. The results show that the effects of the adjacent slopes are important for deep valleys and they particularly affect shadowed pixels, and the topographic effect needs to be considered in mountainous terrain before accurate inferences from remotely sensed data can be made.

Palingol: a declarative programming language to describe nucleic acids' secondary structures and to scan sequence database.

PubMed Central

Billoud, B; Kontic, M; Viari, A

1996-01-01

At the DNA/RNA level, biological signals are defined by a combination of spatial structures and sequence motifs. Until now, few attempts had been made in writing general purpose search programs that take into account both sequence and structure criteria. Indeed, the most successful structure scanning programs are usually dedicated to particular structures and are written using general purpose programming languages through a complex and time consuming process where the biological problem of defining the structure and the computer engineering problem of looking for it are intimately intertwined. In this paper, we describe a general representation of structures, suitable for database scanning, together with a programming language, Palingol, designed to manipulate it. Palingol has specific data types, corresponding to structural elements-basically helices-that can be arranged in any way to form a complex structure. As a consequence of the declarative approach used in Palingol, the user should only focus on 'what to search for' while the language engine takes care of 'how to look for it'. Therefore, it becomes simpler to write a scanning program and the structural constraints that define the required structure are more clearly identified. PMID:8628670

Sleep: An Open-Source Python Software for Visualization, Analysis, and Staging of Sleep Data

PubMed Central

Combrisson, Etienne; Vallat, Raphael; Eichenlaub, Jean-Baptiste; O'Reilly, Christian; Lajnef, Tarek; Guillot, Aymeric; Ruby, Perrine M.; Jerbi, Karim

2017-01-01

We introduce Sleep, a new Python open-source graphical user interface (GUI) dedicated to visualization, scoring and analyses of sleep data. Among its most prominent features are: (1) Dynamic display of polysomnographic data, spectrogram, hypnogram and topographic maps with several customizable parameters, (2) Implementation of several automatic detection of sleep features such as spindles, K-complexes, slow waves, and rapid eye movements (REM), (3) Implementation of practical signal processing tools such as re-referencing or filtering, and (4) Display of main descriptive statistics including publication-ready tables and figures. The software package supports loading and reading raw EEG data from standard file formats such as European Data Format, in addition to a range of commercial data formats. Most importantly, Sleep is built on top of the VisPy library, which provides GPU-based fast and high-level visualization. As a result, it is capable of efficiently handling and displaying large sleep datasets. Sleep is freely available (http://visbrain.org/sleep) and comes with sample datasets and an extensive documentation. Novel functionalities will continue to be added and open-science community efforts are expected to enhance the capacities of this module. PMID:28983246

A Low Cost Sensors Approach for Accurate Vehicle Localization and Autonomous Driving Application.

PubMed

Vivacqua, Rafael; Vassallo, Raquel; Martins, Felipe

2017-10-16

Autonomous driving in public roads requires precise localization within the range of few centimeters. Even the best current precise localization system based on the Global Navigation Satellite System (GNSS) can not always reach this level of precision, especially in an urban environment, where the signal is disturbed by surrounding buildings and artifacts. Laser range finder and stereo vision have been successfully used for obstacle detection, mapping and localization to solve the autonomous driving problem. Unfortunately, Light Detection and Ranging (LIDARs) are very expensive sensors and stereo vision requires powerful dedicated hardware to process the cameras information. In this context, this article presents a low-cost architecture of sensors and data fusion algorithm capable of autonomous driving in narrow two-way roads. Our approach exploits a combination of a short-range visual lane marking detector and a dead reckoning system to build a long and precise perception of the lane markings in the vehicle's backwards. This information is used to localize the vehicle in a map, that also contains the reference trajectory for autonomous driving. Experimental results show the successful application of the proposed system on a real autonomous driving situation.