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Sample records for deep-inelastic ep scattering

  1. Measurement of isolated photons accompanied by jets in deep inelastic ep scattering

    NASA Astrophysics Data System (ADS)

    ZEUS Collaboration; Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Bartosik, N.; Bartsch, D.; Basile, M.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Bertolin, A.; Bhadra, S.; Bindi, M.; Blohm, C.; Bokhonov, V.; Bołd, T.; Bondarenko, K.; Boos, E. G.; Borras, K.; Boscherini, D.; Bot, D.; Brock, I.; Brownson, E.; Brugnera, R.; Brümmer, N.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bussey, P. J.; Bylsma, B.; Caldwell, A.; Capua, M.; Carlin, R.; Catterall, C. D.; Chekanov, S.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; D'Agostini, G.; Dal Corso, F.; del Peso, J.; Dementiev, R. K.; De Pasquale, S.; Derrick, M.; Devenish, R. C. E.; Dobur, D.; Dolgoshein, B. A.; Dolinska, G.; Doyle, A. T.; Drugakov, V.; Durkin, L. S.; Dusini, S.; Eisenberg, Y.; Ermolov, P. F.; Eskreys, A.; Fang, S.; Fazio, S.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Forrest, M.; Foster, B.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gialas, I.; Gizhko, A.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Gogota, O.; Golubkov, Yu. A.; Göttlicher, P.; Grabowska-Bołd, I.; Grebenyuk, J.; Gregor, I.; Grigorescu, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Gwenlan, C.; Haas, T.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Hilger, E.; Hochman, D.; Hori, R.; Hüttmann, A.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Jakob, H.-P.; Januschek, F.; Jones, T. W.; Jüngst, M.; Kadenko, I.; Kahle, B.; Kananov, S.; Kanno, T.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, M.; Kaur, P.; Keramidas, A.; Khein, L. A.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, U.; Koffeman, E.; Kondrashova, N.; Kononenko, O.; Kooijman, P.; Korol, Ie.; Korzhavina, I. A.; Kotański, A.; Kötz, U.; Kowalski, H.; Kuprash, O.; Kuze, M.; Lee, A.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Ling, T. Y.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Magill, S.; Makarenko, I.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Martin, J. F.; Mastroberardino, A.; Mattingly, M. C. K.; Melzer-Pellmann, I.-A.; Mergelmeyer, S.; Miglioranzi, S.; Mohamad Idris, F.; Monaco, V.; Montanari, A.; Morris, J. D.; Mujkic, K.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Nigro, A.; Ning, Y.; Nobe, T.; Notz, D.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Olkiewicz, K.; Onishchuk, Yu.; Papageorgiu, K.; Parenti, A.; Paul, E.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perlański, W.; Perrey, H.; Piotrzkowski, K.; Pluciński, P.; Pokrovskiy, N. S.; Polini, A.; Proskuryakov, A. S.; Przybycień, M.; Raval, A.; Reeder, D. D.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Robertson, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Sacchi, R.; Samson, U.; Sartorelli, G.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schneekloth, U.; Schönberg, V.; Schörner-Sadenius, T.; Schwartz, J.; Sciulli, F.; Shcheglova, L. M.; Shehzadi, R.; Shimizu, S.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Smith, W. H.; Sola, V.; Solano, A.; Son, D.; Sosnovtsev, V.; Spiridonov, A.; Stadie, H.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stopa, P.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tapper, A. D.; Tassi, E.; Terrón, J.; Theedt, T.; Tiecke, H.; Tokushuku, K.; Tomaszewska, J.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Vázquez, M.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Walczak, R.; Wan Abdullah, W. A. T.; Whitmore, J. J.; Wichmann, K.; Wiggers, L.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Yagües-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Zabiegalov, O.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zeuner, W.; Zhautykov, B. O.; Zhmak, N.; Zichichi, A.; Zolkapli, Z.; Zotkin, D. S.

    2012-08-01

    The production of isolated high-energy photons accompanied by jets has been measured in deep inelastic ep scattering with the ZEUS detector at HERA, using an integrated luminosity of 326 pb. Measurements were made for exchanged photon virtualities, Q2, in the range 10 to 350 GeV. The photons were measured in the transverse-energy and pseudorapidity ranges 4

  2. Measurement of D ± production in deep inelastic ep scattering with the ZEUS detector at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Bartosik, N.; Bartsch, D.; Basile, M.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Bertolin, A.; Bhadra, S.; Bindi, M.; Blohm, C.; Bokhonov, V.; Bold, T.; Boos, E. G.; Borras, K.; Boscherini, D.; Bot, D.; Brock, I.; Brownson, E.; Brugnera, R.; Brümmer, N.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bussey, P. J.; Bylsma, B.; Caldwell, A.; Capua, M.; Carlin, R.; Catterall, C. D.; Chekanov, S.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; D'Agostini, G.; Corso, F. Dal; del Peso, J.; Dementiev, R. K.; De Pasquale, S.; Derrick, M.; Devenish, R. C. E.; Dobur, D.; Dolgoshein, B. A.; Dolinska, G.; Doyle, A. T.; Drugakov, V.; Durkin, L. S.; Dusini, S.; Eisenberg, Y.; Ermolov, P. F.; Eskreys, A.; Fang, S.; Fazio, S.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Foster, B.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gialas, I.; Gizhko, A.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Gogota, O.; Golubkov, Yu. A.; Göttlicher, P.; Grabowska-Bold, I.; Grebenyuk, J.; Gregor, I.; Grigorescu, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Gwenlan, C.; Haas, T.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Hilger, E.; Hochman, D.; Hori, R.; Hüttmann, A.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Iudin, A.; Jakob, H.-P.; Januschek, F.; Jones, T. W.; Jüngst, M.; Kadenko, I.; Kahle, B.; Kananov, S.; Kanno, T.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, M.; Kaur, P.; Keramidas, A.; Khein, L. A.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, U.; Koffeman, E.; Kondrashova, N.; Kononenko, O.; Kooijman, P.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Lee, A.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Ling, T. Y.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Magill, S.; Makarenko, I.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Martin, J. F.; Mastroberardino, A.; Mattingly, M. C. K.; Melzer-Pellmann, I.-A.; Mergelmeyer, S.; Miglioranzi, S.; Idris, F. Mohamad; Monaco, V.; Montanari, A.; Morris, J. D.; Mujkic, K.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Nigro, A.; Ning, Y.; Nobe, T.; Notz, D.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Olkiewicz, K.; Onishchuk, Yu.; Papageorgiu, K.; Parenti, A.; Paul, E.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perlanski, W.; Perrey, H.; Piotrzkowski, K.; Plucinski, P.; Pokrovskiy, N. S.; Polini, A.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Reeder, D. D.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Robertson, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Sacchi, R.; Samson, U.; Sartorelli, G.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schneekloth, U.; Schönberg, V.; Schörner-Sadenius, T.; Schwartz, J.; Sciulli, F.; Shcheglova, L. M.; Shehzadi, R.; Shimizu, S.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Smith, W. H.; Sola, V.; Solano, A.; Son, D.; Sosnovtsev, V.; Spiridonov, A.; Stadie, H.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stopa, P.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tapper, A. D.; Tassi, E.; Terrón, J.; Theedt, T.; Tiecke, H.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Vázquez, M.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Walczak, R.; Abdullah, W. A. T. Wan; Whitmore, J. J.; Wichmann, K.; Wiggers, L.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Yagües-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zeuner, W.; Zhautykov, B. O.; Zhmak, N.; Zichichi, A.; Zolkapli, Z.; Zotkin, D. S.

    2013-05-01

    Charm production in deep inelastic ep scattering was measured with the ZEUS detector using an integrated luminosity of 354 pb-1. Charm quarks were identified by reconstructing D ± mesons in the D ± → K ∓π±π± decay channel. Lifetime information was used to reduce combinatorial background substantially. Differential cross sections were measured in the kinematic region 5 < Q 2 < 1000 GeV2, 0 .02 < y < 0 .7, 1 .5 < p T ( D ±) < 15 GeV and | η( D ±)| < 1 .6, where Q 2 is the photon virtuality, y is the inelasticity, and p T ( D ±) and η( D ±) are the transverse momentum and the pseudorapidity of the D ± meson, respectively. Next-to-leading-order QCD predictions are compared to the data. The charm contribution, F_2^{{coverline{c}}} , to the proton structure-function F 2 was extracted.

  3. Measurement of Charged and Neutral Current e-p Deep Inelastic Scattering Cross Sections at High Q2

    NASA Astrophysics Data System (ADS)

    Derrick, M.; Krakauer, D.; Magill, S.; Mikunas, D.; Musgrave, B.; Repond, J.; Stanek, R.; Talaga, R. L.; Zhang, H.; Ayad, R.; Bari, G.; Basile, M.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Bruni, P.; Cara Romeo, G.; Castellini, G.; Chiarini, M.; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; Gialas, I.; Giusti, P.; Iacobucci, G.; Laurenti, G.; Levi, G.; Margotti, A.; Massam, T.; Nania, R.; Nemoz, C.; Palmonari, F.; Polini, A.; Sartorelli, G.; Timellini, R.; Zamora Garcia, Y.; Zichichi, A.; Bargende, A.; Crittenden, J.; Desch, K.; Diekmann, B.; Doeker, T.; Eckert, M.; Feld, L.; Frey, A.; Geerts, M.; Geitz, G.; Grothe, M.; Haas, T.; Hartmann, H.; Haun, D.; Heinloth, K.; Hilger, E.; Jakob, H.-P.; Katz, U. F.; Mari, S. M.; Mass, A.; Mengel, S.; Mollen, J.; Paul, E.; Rembser, Ch.; Schattevoy, R.; Schramm, D.; Stamm, J.; Wedemeyer, R.; Campbell-Robson, S.; Cassidy, A.; Dyce, N.; Foster, B.; George, S.; Gilmore, R.; Heath, G. P.; Heath, H. F.; Llewellyn, T. J.; Morgado, C. J.; Norman, D. J.; O'Mara, J. A.; Tapper, R. J.; Wilson, S. S.; Yoshida, R.; Rau, R. R.; Arneodo, M.; Iannotti, L.; Schioppa, M.; Susinno, G.; Bernstein, A.; Caldwell, A.; Cartiglia, N.; Parsons, J. A.; Ritz, S.; Sciulli, F.; Straub, P. B.; Wai, L.; Yang, S.; Zhu, Q.; Borzemski, P.; Chwastowski, J.; Eskreys, A.; Piotrzkowski, K.; Zachara, M.; Zawiejski, L.; Adamczyk, L.; Bednarek, B.; Jeleń, K.; Kisielewska, D.; Kowalski, T.; Rulikowska-Zarȩbska, E.; Suszycki, L.; ZajaÇ, J.; Kotański, A.; Przybycień, M.; Bauerdick, L. A.; Behrens, U.; Beier, H.; Bienlein, J. K.; Coldewey, C.; Deppe, O.; Desler, K.; Drews, G.; Flasiński, M.; Gilkinson, D. J.; Glasman, C.; Göttlicher, P.; Grosse-Knetter, J.; Gutjahr, B.; Hain, W.; Hasell, D.; Hessling, H.; Hultschig, H.; Iga, Y.; Joos, P.; Kasemann, M.; Klanner, R.; Koch, W.; Köpke, L.; Kötz, U.; Kowalski, H.; Labs, J.; Ladage, A.; Löhr, B.; Löwe, M.; Lüke, D.; Mańczak, O.; Ng, J. S.; Nickel, S.; Notz, D.; Ohrenberg, K.; Roco, M.; Rohde, M.; Roldán, J.; Schneekloth, U.; Schulz, W.; Selonke, F.; Stiliaris, E.; Surrow, B.; Voss, T.; Westphal, D.; Wolf, G.; Youngman, C.; Zhou, J. F.; Grabosch, H. J.; Kharchilava, A.; Leich, A.; Mattingly, M.; Meyer, A.; Schlenstedt, S.; Wulff, N.; Barbagli, G.; Pelfer, P.; Anzivino, G.; Maccarrone, G.; de Pasquale, S.; Votano, L.; Bamberger, A.; Eisenhardt, S.; Freidhof, A.; Söldner-Rembold, S.; Schroeder, J.; Trefzger, T.; Brook, N. H.; Bussey, P. J.; Doyle, A. T.; Fleck, J. I.; Saxon, D. H.; Utley, M. L.; Wilson, A. S.; Dannemann, A.; Holm, U.; Horstmann, D.; Neumann, T.; Sinkus, R.; Wick, K.; Badura, E.; Burow, B. D.; Hagge, L.; Lohrmann, E.; Mainusch, J.; Milewski, J.; Nakahata, M.; Pavel, N.; Poelz, G.; Schott, W.; Zetsche, F.; Bacon, T. C.; Butterworth, I.; Gallo, E.; Harris, V. L.; Hung, B. Y.; Long, K. R.; Miller, D. B.; Morawitz, P. P.; Prinias, A.; Sedgbeer, J. K.; Whitfield, A. F.; Mallik, U.; McCliment, E.; Wang, M. Z.; Wang, S. M.; Wu, J. T.; Zhang, Y.; Cloth, P.; Filges, D.; An, S. H.; Hong, S. M.; Nam, S. W.; Park, S. K.; Suh, M. H.; Yon, S. H.; Imlay, R.; Kartik, S.; Kim, H.-J.; McNeil, R. R.; Metcalf, W.; Nadendla, V. K.; Barreiro, F.; Cases, G.; Graciani, R.; Hernández, J. M.; Hervás, L.; Labarga, L.; del Peso, J.; Puga, J.; Terron, J.; de Trocóniz, J. F.; Smith, G. R.; Corriveau, F.; Hanna, D. S.; Hartmann, J.; Hung, L. W.; Lim, J. N.; Matthews, C. G.; Patel, P. M.; Sinclair, L. E.; Stairs, D. G.; St. Laurent, M.; Ullmann, R.; Zacek, G.; Bashkirov, V.; Dolgoshein, B. A.; Stifutkin, A.; Bashindzhagyan, G. L.; Ermolov, P. F.; Gladilin, L. K.; Golubkov, Y. A.; Kobrin, V. D.; Kuzmin, V. A.; Proskuryakov, A. S.; Savin, A. A.; Shcheglova, L. M.; Solomin, A. N.; Zotov, N. P.; Botje, M.; Chlebana, F.; Dake, A.; Engelen, J.; de Kamps, M.; Kooijman, P.; Kruse, A.; Tiecke, H.; Verkerke, W.; Vreeswijk, M.; Wiggers, L.; de Wolf, E.; van Woudenberg, R.; Acosta, D.; Bylsma, B.; Durkin, L. S.; Honscheid, K.; Li, C.; Ling, T. Y.; McLean, K. W.; Murray, W. N.; Park, I. H.; Romanowski, T. A.; Seidlein, R.; Bailey, D. S.; Blair, G. A.; Byrne, A.; Cashmore, R. J.; Cooper-Sarkar, A. M.; Daniels, D.; Devenish, R. C.; Harnew, N.; Lancaster, M.; Luffman, P. E.; Lindemann, L.; McFall, J. D.; Nath, C.; Noyes, V. A.; Quadt, A.; Uijterwaal, H.; Walczak, R.; Wilson, F. F.; Yip, T.; Abbiendi, G.; Bertolin, A.; Brugnera, R.; Carlin, R.; dal Corso, F.; de Giorgi, M.; Dosselli, U.; Limentani, S.; Morandin, M.; Posocco, M.; Stanco, L.; Stroili, R.; Voci, C.; Bulmahn, J.; Butterworth, J. M.; Feild, R. G.; Oh, B. Y.; Whitmore, J. J.; D'Agostini, G.; Marini, G.; Nigro, A.; Tassi, E.; Hart, J. C.; McCubbin, N. A.; Prytz, K.; Shah, T. P.; Short, T. L.; Barberis, E.; Dubbs, T.; Heusch, C.; van Hook, M.; Hubbard, B.; Lockman, W.; Rahn, J. T.; Sadrozinski, H. F.-W.; Seiden, A.; Biltzinger, J.; Schwarzer, O.; Seifert, R. J.; Walenta, A. H.; Zech, G.; Abramowicz, H.; Briskin, G.; Dagan, S.; Levy, A.; Hasegawa, T.; Hazumi, M.; Ishii, T.; Kuze, M.; Mine, S.; Nagasawa, Y.; Nakao, M.; Suzuki, I.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Chiba, M.; Hamatsu, R.; Hirose, T.; Homma, K.; Kitamura, S.; Nakamitsu, Y.; Yamauchi, K.; Cirio, R.; Costa, M.; Ferrero, M. I.; Lamberti, L.; Maselli, S.; Peroni, C.; Sacchi, R.; Solano, A.; Staiano, A.; Dardo, M.; Bailey, D. C.; Bandyopadhyay, D.; Benard, F.; Brkic, M.; Crombie, M. B.; Gingrich, D. M.; Hartner, G. F.; Joo, K. K.; Levman, G. M.; Martin, J. F.; Orr, R. S.; Sampson, C. R.; Teuscher, R. J.; Catterall, C. D.; Jones, T. W.; Kaziewicz, P. B.; Lane, J. B.; Saunders, R. L.; Shulman, J.; Blankenship, K.; Kochocki, J.; Lu, B.; Mo, L. W.; Bogusz, W.; Charchuła, K.; Ciborowski, J.; Gajewski, J.; Grzelak, G.; Kasprzak, M.; Krzyżanowski, M.; Muchorowski, K.; Nowak, R. J.; Pawlak, J. M.; Tymieniecka, T.; Wróblewski, A. K.; Zakrzewski, J. A.; Żarnecki, A. F.; Adamus, M.; Eisenberg, Y.; Karshon, U.; Revel, D.; Zer-Zion, D.; Ali, I.; Badgett, W. F.; Behrens, B.; Dasu, S.; Fordham, C.; Foudas, C.; Goussiou, A.; Loveless, R. J.; Reeder, D. D.; Silverstein, S.; Smith, W. H.; Vaiciulis, A.; Wodarczyk, M.; Tsurugai, T.; Bhadra, S.; Cardy, M. L.; Fagerstroem, C.-P.; Frisken, W. R.; Furutani, K. M.; Khakzad, M.; Schmidke, W. B.

    1995-08-01

    Deep inelastic e-p scattering has been studied in both the charged current (CC) and neutral current (NC) reactions at momentum transfers squared Q2 above 400 GeV2 using the ZEUS detector at the HERA ep collider. The CC and NC total cross sections, the NC to CC cross section ratio, and the differential cross sections dσ/dQ2 are presented. From the Q2 dependence of the CC cross section, the mass term in the CC propagator is determined to be MW = 76+/-16+/-13 GeV.

  4. NEW APPROACHES: Deep inelastic scattering

    NASA Astrophysics Data System (ADS)

    Allday, J.

    1998-01-01

    Feynman diagrams can be used to explain deep inelastic scattering, but it must be remembered that the emission and absorption of a photon are not independent events - the underlying field is important.

  5. Combination and QCD analysis of charm production cross section measurements in deep-inelastic ep scattering at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Alexa, C.; Andreev, V.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Baghdasaryan, A.; Baghdasaryan, S.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Bartel, W.; Bartosik, N.; Bartsch, D.; Basile, M.; Begzsuren, K.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Belousov, A.; Belov, P.; Bertolin, A.; Bhadra, S.; Bindi, M.; Blohm, C.; Bokhonov, V.; Bondarenko, K.; Boos, E. G.; Borras, K.; Boscherini, D.; Bot, D.; Boudry, V.; Bozovic-Jelisavcic, I.; Bołd, T.; Brümmer, N.; Bracinik, J.; Brandt, G.; Brinkmann, M.; Brisson, V.; Britzger, D.; Brock, I.; Brownson, E.; Brugnera, R.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bunyatyan, A.; Bussey, P. J.; Bylinkin, A.; Bylsma, B.; Bystritskaya, L.; Caldwell, A.; Campbell, A. J.; Cantun Avila, K. B.; Capua, M.; Carlin, R.; Catterall, C. D.; Ceccopieri, F.; Cerny, K.; Chekanov, S.; Chekelian, V.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Contreras, J. G.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; Cvach, J.; D'Agostini, G.; Dainton, J. B.; Dal Corso, F.; Daum, K.; Delvax, J.; Dementiev, R. K.; Derrick, M.; Devenish, R. C. E.; De Pasquale, S.; De Wolf, E. A.; del Peso, J.; Diaconu, C.; Dobre, M.; Dobur, D.; Dodonov, V.; Dolgoshein, B. A.; Dolinska, G.; Dossanov, A.; Doyle, A. T.; Drugakov, V.; Durkin, L. S.; Dusini, S.; Eckerlin, G.; Egli, S.; Eisenberg, Y.; Elsen, E.; Ermolov, P. F.; Eskreys, A.; Fang, S.; Favart, L.; Fazio, S.; Fedotov, A.; Felst, R.; Feltesse, J.; Ferencei, J.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Fischer, D.-J.; Fleischer, M.; Fomenko, A.; Foster, B.; Gabathuler, E.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Gayler, J.; Geiser, A.; Ghazaryan, S.; Gialas, I.; Gizhko, A.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Glazov, A.; Goerlich, L.; Gogitidze, N.; Gogota, O.; Golubkov, Y. A.; Göttlicher, P.; Gouzevitch, M.; Grab, C.; Grabowska-Bołd, I.; Grebenyuk, A.; Grebenyuk, J.; Greenshaw, T.; Gregor, I.; Grigorescu, G.; Grindhammer, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Gwenlan, C.; Hüttmann, A.; Haas, T.; Habib, S.; Haidt, D.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Henderson, R. C. W.; Hennekemper, E.; Henschel, H.; Herbst, M.; Herrera, G.; Hildebrandt, M.; Hilger, E.; Hiller, K. H.; Hladký, J.; Hochman, D.; Hoffmann, D.; Hori, R.; Horisberger, R.; Hreus, T.; Huber, F.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Jacquet, M.; Jakob, H.-P.; Janssen, X.; Januschek, F.; Jones, T. W.; Jönsson, L.; Jüngst, M.; Jung, A. W.; Jung, H.; Kadenko, I.; Kahle, B.; Kananov, S.; Kanno, T.; Kapichine, M.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, P.; Kaur, M.; Kenyon, I. R.; Keramidas, A.; Khein, L. A.; Kiesling, C.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, M.; Klein, U.; Kleinwort, C.; Kötz, U.; Koffeman, E.; Kogler, R.; Kondrashova, N.; Kononenko, O.; Kooijman, P.; Korol, I.; Korzhavina, I. A.; Kostka, P.; Kotański, A.; Kowalski, H.; Krämer, M.; Kretzschmar, J.; Krüger, K.; Kuprash, O.; Kuze, M.; Landon, M. P. J.; Lange, W.; Laštovička-Medin, G.; Laycock, P.; Lebedev, A.; Lee, A.; Lendermann, V.; Levchenko, B. B.; Levonian, S.; Levy, A.; Libov, V.; Limentani, S.; Ling, T. Y.; Lipka, K.; Lisovyi, M.; List, B.; List, J.; Lobodzinska, E.; Lobodzinski, B.; Löhr, B.; Lohmann, W.; Lohrmann, E.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lopez-Fernandez, R.; Lubimov, V.; Lukina, O. Y.; Maeda, J.; Magill, S.; Makarenko, I.; Malinovski, E.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Martin, J. F.; Martyn, H.-U.; Mastroberardino, A.; Mattingly, M. C. K.; Maxfield, S. J.; Mehta, A.; Melzer-Pellmann, I.-A.; Mergelmeyer, S.; Meyer, A. B.; Meyer, H.; Meyer, J.; Miglioranzi, S.; Mikocki, S.; Milcewicz-Mika, I.; Mohamad Idris, F.; Monaco, V.; Montanari, A.; Moreau, F.; Morozov, A.; Morris, J. V.; Morris, J. D.; Mujkic, K.; Müller, K.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Naumann, T.; Newman, P. R.; Niebuhr, C.; Nigro, A.; Nikitin, D.; Ning, Y.; Nobe, T.; Notz, D.; Nowak, G.; Nowak, K.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Olkiewicz, K.; Olsson, J. E.; Onishchuk, Y.; Ozerov, D.; Pahl, P.; Palichik, V.; Pandurovic, M.; Papageorgiu, K.; Parenti, A.; Pascaud, C.; Patel, G. D.; Paul, E.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perez, E.; Perlański, W.; Perrey, H.; Petrukhin, A.; Picuric, I.; Piotrzkowski, K.; Pirumov, H.; Pitzl, D.; Plačakytė, R.; Pluciński, P.; Pokorny, B.; Pokrovskiy, N. S.; Polifka, R.; Polini, A.; Povh, B.; Proskuryakov, A. S.; Przybycień, M.; Radescu, V.; Raicevic, N.; Raval, A.; Ravdandorj, T.; Reeder, D. D.; Reimer, P.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Rizvi, E.; Robertson, A.; Robmann, P.; Roloff, P.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Rubinsky, I.; Ruiz Tabasco, J. E.; Rusakov, S.; Ruspa, M.; Sacchi, R.; Šálek, D.; Samson, U.; Sankey, D. P. C.; Sartorelli, G.; Sauter, M.; Sauvan, E.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schmitt, S.; Schneekloth, U.; Schoeffel, L.; Schönberg, V.; Schöning, A.; Schörner-Sadenius, T.; Schultz-Coulon, H.-C.; Schwartz, J.; Sciulli, F.; Sefkow, F.; Shcheglova, L. M.; Shehzadi, R.; Shimizu, S.; Shushkevich, S.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Smith, W. H.; Sola, V.; Solano, A.; Soloviev, Y.; Son, D.; Sopicki, P.; Sosnovtsev, V.; South, D.; Spaskov, V.; Specka, A.; Spiridonov, A.; Stadie, H.; Stanco, L.; Staykova, Z.; Steder, M.; Stefaniuk, N.; Stella, B.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stoicea, G.; Stopa, P.; Straumann, U.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sykora, T.; Sztuk-Dambietz, J.; Szuba, J.; Szuba, D.; Tapper, A. D.; Tassi, E.; Terrón, J.; Theedt, T.; Thompson, P. D.; Tiecke, H.; Tokushuku, K.; Tomaszewska, J.; Tran, T. H.; Traynor, D.; Truöl, P.; Trusov, V.; Tsakov, I.; Tseepeldorj, B.; Tsurugai, T.; Turcato, M.; Turkot, O.; Turnau, J.; Tymieniecka, T.; Vázquez, M.; Valkárová, A.; Vallée, C.; Van Mechelen, P.; Vazdik, Y.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Walczak, R.; Wan Abdullah, W. A. T.; Wegener, D.; Whitmore, J. J.; Wichmann, K.; Wiggers, L.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Wünsch, E.; Yagües-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Zabiegalov, O.; Žáček, J.; Zálešák, J.; Zenaiev, O.; Zeuner, W.; Zhang, Z.; Zhautykov, B. O.; Zhmak, N.; Zichichi, A.; Žlebčík, R.; Zohrabyan, H.; Zolkapli, Z.; Zomer, F.; Zotkin, D. S.; Żarnecki, A. F.

    2013-02-01

    Measurements of open charm production cross sections in deep-inelastic ep scattering at HERA from the H1 and ZEUS Collaborations are combined. Reduced cross sections σ_red^{cbar{c}} for charm production are obtained in the kinematic range of photon virtuality 2.5≤ Q 2≤2000 GeV2 and Bjorken scaling variable 3ṡ10-5≤ x≤5ṡ10-2. The combination method accounts for the correlations of the systematic uncertainties among the different data sets. The combined charm data together with the combined inclusive deep-inelastic scattering cross sections from HERA are used as input for a detailed NLO QCD analysis to study the influence of different heavy flavour schemes on the parton distribution functions. The optimal values of the charm mass as a parameter in these different schemes are obtained. The implications on the NLO predictions for W ± and Z production cross sections at the LHC are investigated. Using the fixed flavour number scheme, the running mass of the charm quark is determined.

  6. Combination of differential D∗± cross-section measurements in deep-inelastic ep scattering at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Andreev, V.; Antonelli, S.; Aushev, V.; Aushev, Y.; Baghdasaryan, A.; Begzsuren, K.; Behnke, O.; Behrens, U.; Belousov, A.; Bertolin, A.; Bloch, I.; Boos, E. G.; Borras, K.; Boudry, V.; Brandt, G.; Brisson, V.; Britzger, D.; Brock, I.; Brook, N. H.; Brugnera, R.; Bruni, A.; Buniatyan, A.; Bussey, P. J.; Bylinkin, A.; Bystritskaya, L.; Caldwell, A.; Campbell, A. J.; Avila, K. B. Cantun; Capua, M.; Catterall, C. D.; Ceccopieri, F.; Cerny, K.; Chekelian, V.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Contreras, J. G.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; Cvach, J.; Dainton, J. B.; Daum, K.; Dementiev, R. K.; Devenish, R. C. E.; Diaconu, C.; Dobre, M.; Dodonov, V.; Dolinska, G.; Dusini, S.; Eckerlin, G.; Egli, S.; Elsen, E.; Favart, L.; Fedotov, A.; Feltesse, J.; Ferencei, J.; Figiel, J.; Fleischer, M.; Fomenko, A.; Foster, B.; Gabathuler, E.; Gach, G.; Gallo, E.; Garfagnini, A.; Gayler, J.; Geiser, A.; Ghazaryan, S.; Gizhko, A.; Gladilin, L. K.; Goerlich, L.; Gogitidze, N.; Golubkov, Yu. A.; Gouzevitch, M.; Grab, C.; Grebenyuk, A.; Grebenyuk, J.; Greenshaw, T.; Gregor, I.; Grindhammer, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Haidt, D.; Hain, W.; Henderson, R. C. W.; Hladky, J.; Hochman, D.; Hoffmann, D.; Hori, R.; Horisberger, R.; Hreus, T.; Huber, F.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Jacquet, M.; Janssen, X.; Januschek, F.; Jomhari, N. Z.; Jung, A. W.; Jung, H.; Kadenko, I.; Kananov, S.; Kapichine, M.; Karshon, U.; Kaur, M.; Kaur, P.; Kiesling, C.; Kisielewska, D.; Klanner, R.; Klein, M.; Klein, U.; Kleinwort, C.; Kogler, R.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kostka, P.; Kotanski, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kretzschmar, J.; Krüger, K.; Krupa, B.; Kuprash, O.; Kuze, M.; Landon, M. P. J.; Lange, W.; Laycock, P.; Lebedev, A.; Levchenko, B. B.; Levonian, S.; Levy, A.; Libov, V.; Limentani, S.; Lipka, K.; Lisovyi, M.; List, B.; List, J.; Lobodzinska, E.; Lobodzinski, B.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Makarenko, I.; Malinovski, E.; Malka, J.; Martyn, H.-U.; Maxfield, S. J.; Mehta, A.; Mergelmeyer, S.; Meyer, A. B.; Meyer, H.; Meyer, J.; Mikocki, S.; Mohamad Idris, F.; Morozov, A.; Muhammad Nasir, N.; Müller, K.; Myronenko, V.; Nagano, K.; Naumann, Th.; Newman, P. R.; Niebuhr, C.; Nobe, T.; Notz, D.; Nowak, G.; Nowak, R. J.; Olsson, J. E.; Onishchuk, Yu.; Ozerov, D.; Pahl, P.; Pascaud, C.; Patel, G. D.; Paul, E.; Perez, E.; Perlanski, W.; Petrukhin, A.; Picuric, I.; Pirumov, H.; Pitzl, D.; Plačakytė, R.; Pokorny, B.; Pokrovskiy, N. S.; Polifka, R.; Przybycien, M.; Radescu, V.; Raicevic, N.; Ravdandorj, T.; Reimer, P.; Rizvi, E.; Robmann, P.; Roloff, P.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Rubinsky, I.; Rusakov, S.; Ruspa, M.; Šálek, D.; Sankey, D. P. C.; Sauter, M.; Sauvan, E.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schmitt, S.; Schneekloth, U.; Schoeffel, L.; Schöning, A.; Schörner-Sadenius, T.; Sefkow, F.; Shcheglova, L. M.; Shevchenko, R.; Shkola, O.; Shushkevich, S.; Shyrma, Yu.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Solano, A.; Soloviev, Y.; Sopicki, P.; South, D.; Spaskov, V.; Specka, A.; Stanco, L.; Steder, M.; Stefaniuk, N.; Stern, A.; Stopa, P.; Straumann, U.; Sykora, T.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Thompson, P. D.; Tokushuku, K.; Tomaszewska, J.; Traynor, D.; Trofymov, A.; Truöl, P.; Tsakov, I.; Tseepeldorj, B.; Tsurugai, T.; Turcato, M.; Turkot, O.; Turnau, J.; Tymieniecka, T.; Valkárová, A.; Vallée, C.; Van Mechelen, P.; Vazdik, Y.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wegener, D.; Wichmann, K.; Wing, M.; Wolf, G.; Wünsch, E.; Yamada, S.; Yamazaki, Y.; Žáček, J.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhang, Z.; Zhautykov, B. O.; Zhmak, N.; Žlebčík, R.; Zohrabyan, H.; Zomer, F.; Zotkin, D. S.

    2015-09-01

    H1 and ZEUS have published single-differential cross sections for inclusive D ∗±-meson production in deep-inelastic ep scattering at HERA from their respective final data sets. These cross sections are combined in the common visible phase-space region of photon virtuality Q 2 > 5 GeV2, electron inelasticity 0 .02 < y < 0 .7 and the D ∗± meson's transverse momentum p T( D ∗) > 1 .5 GeV and pseudorapidity | η( D ∗)| < 1 .5. The combination procedure takes into account all correlations, yielding significantly reduced experimental uncertainties. Double-differential cross sections d2 σ/d Q 2d y are combined with earlier D ∗± data, extending the kinematic range down to Q 2 > 1 .5 GeV2. Perturbative next-to-leading-order QCD predictions are compared to the results.

  7. Combined inclusive diffractive cross sections measured with forward proton spectrometers in deep inelastic ep scattering at HERA

    NASA Astrophysics Data System (ADS)

    Aaron, F. D.; Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Alexa, C.; Andreev, V.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Backovic, S.; Baghdasaryan, A.; Baghdasaryan, S.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Barrelet, E.; Bartel, W.; Bartosik, N.; Bartsch, D.; Basile, M.; Begzsuren, K.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Belousov, A.; Belov, P.; Bertolin, A.; Bhadra, S.; Bindi, M.; Bizot, J. C.; Blohm, C.; Bokhonov, V.; Bondarenko, K.; Boos, E. G.; Borras, K.; Boscherini, D.; Bot, D.; Boudry, V.; Bozovic-Jelisavcic, I.; Bołd, T.; Brümmer, N.; Bracinik, J.; Brandt, G.; Brinkmann, M.; Brisson, V.; Britzger, D.; Brock, I.; Brownson, E.; Brugnera, R.; Bruncko, D.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bunyatyan, A.; Bussey, P. J.; Bylinkin, A.; Bylsma, B.; Bystritskaya, L.; Caldwell, A.; Campbell, A. J.; Cantun Avila, K. B.; Capua, M.; Carlin, R.; Catterall, C. D.; Ceccopieri, F.; Cerny, K.; Cerny, V.; Chekanov, S.; Chekelian, V.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Contreras, J. G.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; Coughlan, J. A.; Cvach, J.; D'Agostini, G.; Dainton, J. B.; Dal Corso, F.; Daum, K.; Delcourt, B.; Delvax, J.; Dementiev, R. K.; Derrick, M.; Devenish, R. C. E.; De Pasquale, S.; De Wolf, E. A.; del Peso, J.; Diaconu, C.; Dobre, M.; Dobur, D.; Dodonov, V.; Dolgoshein, B. A.; Dolinska, G.; Dossanov, A.; Doyle, A. T.; Drugakov, V.; Dubak, A.; Durkin, L. S.; Dusini, S.; Eckerlin, G.; Egli, S.; Eisenberg, Y.; Eliseev, A.; Elsen, E.; Ermolov, P. F.; Eskreys, A.; Fang, S.; Favart, L.; Fazio, S.; Fedotov, A.; Felst, R.; Feltesse, J.; Ferencei, J.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Fischer, D.-J.; Fleischer, M.; Fomenko, A.; Forrest, M.; Foster, B.; Gabathuler, E.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Gayler, J.; Geiser, A.; Ghazaryan, S.; Gialas, I.; Gizhko, A.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Glazov, A.; Goerlich, L.; Gogitidze, N.; Gogota, O.; Golubkov, Y. A.; Göttlicher, P.; Gouzevitch, M.; Grab, C.; Grabowska-Bołd, I.; Grebenyuk, A.; Grebenyuk, J.; Greenshaw, T.; Gregor, I.; Grigorescu, G.; Grindhammer, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Gwenlan, C.; Hüttmann, A.; Haas, T.; Habib, S.; Haidt, D.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Henderson, R. C. W.; Hennekemper, E.; Henschel, H.; Herbst, M.; Herrera, G.; Hildebrandt, M.; Hilger, E.; Hiller, K. H.; Hladký, J.; Hochman, D.; Hoffmann, D.; Hori, R.; Horisberger, R.; Hreus, T.; Huber, F.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Jacquet, M.; Jakob, H.-P.; Janssen, X.; Januschek, F.; Jones, T. W.; Jönsson, L.; Jüngst, M.; Jung, H.; Kadenko, I.; Kahle, B.; Kananov, S.; Kanno, T.; Kapichine, M.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, P.; Kaur, M.; Kenyon, I. R.; Keramidas, A.; Khein, L. A.; Kiesling, C.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, M.; Klein, U.; Kleinwort, C.; Koffeman, E.; Kogler, R.; Kondrashova, N.; Kononenko, O.; Kooijman, P.; Korol, I.; Korzhavina, I. A.; Kostka, P.; Kotański, A.; Kötz, U.; Kowalski, H.; Krämer, M.; Kretzschmar, J.; Krüger, K.; Kuprash, O.; Kuze, M.; Landon, M. P. J.; Lange, W.; Laštovička-Medin, G.; Laycock, P.; Lebedev, A.; Lee, A.; Lendermann, V.; Levchenko, B. B.; Levonian, S.; Levy, A.; Libov, V.; Limentani, S.; Ling, T. Y.; Lipka, K.; Lisovyi, M.; List, B.; List, J.; Lobodzinska, E.; Lobodzinski, B.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lopez-Fernandez, R.; Lubimov, V.; Lukina, O. Y.; Maeda, J.; Magill, S.; Makarenko, I.; Malinovski, E.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Martin, J. F.; Martyn, H.-U.; Mastroberardino, A.; Mattingly, M. C. K.; Maxfield, S. J.; Mehta, A.; Melzer-Pellmann, I.-A.; Mergelmeyer, S.; Meyer, A. B.; Meyer, H.; Meyer, J.; Miglioranzi, S.; Mikocki, S.; Milcewicz-Mika, I.; Mohamad Idris, F.; Monaco, V.; Montanari, A.; Moreau, F.; Morozov, A.; Morris, J. V.; Morris, J. D.; Mujkic, K.; Müller, K.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Naumann, T.; Newman, P. R.; Niebuhr, C.; Nigro, A.; Nikitin, D.; Ning, Y.; Nobe, T.; Notz, D.; Nowak, G.; Nowak, K.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Olkiewicz, K.; Olsson, J. E.; Onishchuk, Y.; Ozerov, D.; Pahl, P.; Palichik, V.; Pandurovic, M.; Papageorgiu, K.; Parenti, A.; Pascaud, C.; Patel, G. D.; Paul, E.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perez, E.; Perlański, W.; Perrey, H.; Petrukhin, A.; Picuric, I.; Piotrzkowski, K.; Pirumov, H.; Pitzl, D.; Plačakytė, R.; Pluciński, P.; Pokorny, B.; Pokrovskiy, N. S.; Polifka, R.; Polini, A.; Povh, B.; Proskuryakov, A. S.; Przybycień, M.; Radescu, V.; Raicevic, N.; Raval, A.; Ravdandorj, T.; Reeder, D. D.; Reimer, P.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Rizvi, E.; Robertson, A.; Robmann, P.; Roloff, P.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Rubinsky, I.; Ruiz Tabasco, J. E.; Rusakov, S.; Ruspa, M.; Sacchi, R.; Šálek, D.; Samson, U.; Sankey, D. P. C.; Sartorelli, G.; Sauter, M.; Sauvan, E.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schmitt, S.; Schneekloth, U.; Schoeffel, L.; Schönberg, V.; Schöning, A.; Schörner-Sadenius, T.; Schultz-Coulon, H.-C.; Schwartz, J.; Sciulli, F.; Sefkow, F.; Shcheglova, L. M.; Shehzadi, R.; Shimizu, S.; Shtarkov, L. N.; Shushkevich, S.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Sloan, T.; Smith, W. H.; Sola, V.; Solano, A.; Soloviev, Y.; Son, D.; Sopicki, P.; Sosnovtsev, V.; South, D.; Spaskov, V.; Specka, A.; Spiridonov, A.; Stadie, H.; Stanco, L.; Staykova, Z.; Steder, M.; Stefaniuk, N.; Stella, B.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stoicea, G.; Stopa, P.; Straumann, U.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sykora, T.; Sztuk-Dambietz, J.; Szuba, J.; Szuba, D.; Tapper, A. D.; Tassi, E.; Terrón, J.; Theedt, T.; Thompson, P. D.; Tiecke, H.; Tokushuku, K.; Tomaszewska, J.; Tran, T. H.; Traynor, D.; Truöl, P.; Trusov, V.; Tsakov, I.; Tseepeldorj, B.; Tsurugai, T.; Turcato, M.; Turkot, O.; Turnau, J.; Tymieniecka, T.; Vázquez, M.; Valkárová, A.; Vallée, C.; Van Mechelen, P.; Vazdik, Y.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Walczak, R.; Wan Abdullah, W. A. T.; Wegener, D.; Whitmore, J. J.; Wichmann, K.; Wiggers, L.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Wünsch, E.; Yagües-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Zabiegalov, O.; Žáček, J.; Zálešák, J.; Zawiejski, L.; Zenaiev, O.; Zeuner, W.; Zhang, Z.; Zhautykov, B. O.; Zhmak, N.; Zhokin, A.; Zichichi, A.; Žlebčík, R.; Zohrabyan, H.; Zolkapli, Z.; Zomer, F.; Zotkin, D. S.; Żarnecki, A. F.

    2012-10-01

    A combination of the inclusive diffractive cross section measurements made by the H1 and ZEUS Collaborations at HERA is presented. The analysis uses samples of diffractive deep inelastic ep scattering data at a centre-of-mass energy sqrt{s}=318 GeV where leading protons are detected by dedicated spectrometers. Correlations of systematic uncertainties are taken into account, resulting in an improved precision of the cross section measurement which reaches 6 % for the most precise points. The combined data cover the range 2.5< Q 2<200 GeV2 in photon virtuality, 0.00035 < {x_{{P}}}< 0.09 in proton fractional momentum loss, 0.09<| t|<0.55 GeV2 in squared four-momentum transfer at the proton vertex and 0.0018< β<0.816 in β=x/{x_{{P}}}, where x is the Bjorken scaling variable.

  8. Parity violation in deep inelastic scattering

    SciTech Connect

    Souder, P.

    1994-04-01

    AA beam of polarized electrons at CEBAF with an energy of 8 GeV or more will be useful for performing precision measurements of parity violation in deep inelastic scattering. Possible applications include precision tests of the Standard Model, model-independent measurements of parton distribution functions, and studies of quark correlations.

  9. Deep inelastic scattering near the Coulomb barrier

    SciTech Connect

    Gehring, J.; Back, B.; Chan, K.

    1995-08-01

    Deep inelastic scattering was recently observed in heavy ion reactions at incident energies near and below the Coulomb barrier. Traditional models of this process are based on frictional forces and are designed to predict the features of deep inelastic processes at energies above the barrier. They cannot be applied at energies below the barrier where the nuclear overlap is small and friction is negligible. The presence of deep inelastic scattering at these energies requires a different explanation. The first observation of deep inelastic scattering near the barrier was in the systems {sup 124,112}Sn + {sup 58,64}Ni by Wolfs et al. We previously extended these measurements to the system {sup 136}Xe + {sup 64}Ni and currently measured the system {sup 124}Xe + {sup 58}Ni. We obtained better statistics, better mass and energy resolution, and more complete angular coverage in the Xe + Ni measurements. The cross sections and angular distributions are similar in all of the Sn + Ni and Xe + Ni systems. The data are currently being analyzed and compared with new theoretical calculations. They will be part of the thesis of J. Gehring.

  10. Measurement of high-Q2 neutral current deep inelastic e+p scattering cross sections with a longitudinally polarized positron beam at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Bartosik, N.; Bartsch, D.; Basile, M.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Bertolin, A.; Bhadra, S.; Bindi, M.; Blohm, C.; Bokhonov, V.; Bołd, T.; Bondarenko, K.; Boos, E. G.; Borras, K.; Boscherini, D.; Bot, D.; Brock, I.; Brownson, E.; Brugnera, R.; Brümmer, N.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bussey, P. J.; Bylsma, B.; Caldwell, A.; Capua, M.; Carlin, R.; Catterall, C. D.; Chekanov, S.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; D'Agostini, G.; Dal Corso, F.; del Peso, J.; Dementiev, R. K.; De Pasquale, S.; Derrick, M.; Devenish, R. C. E.; Dobur, D.; Dolgoshein, B. A.; Dolinska, G.; Doyle, A. T.; Drugakov, V.; Durkin, L. S.; Dusini, S.; Eisenberg, Y.; Ermolov, P. F.; Eskreys, A.; Fang, S.; Fazio, S.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Foster, B.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gialas, I.; Gizhko, A.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Gogota, O.; Golubkov, Yu. A.; Göttlicher, P.; Grabowska-Bołd, I.; Grebenyuk, J.; Gregor, I.; Grigorescu, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Gwenlan, C.; Haas, T.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Hilger, E.; Hochman, D.; Hori, R.; Hüttmann, A.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Jakob, H.-P.; Januschek, F.; Jones, T. W.; Jüngst, M.; Kadenko, I.; Kahle, B.; Kananov, S.; Kanno, T.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, M.; Kaur, P.; Keramidas, A.; Khein, L. A.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, U.; Koffeman, E.; Kondrashova, N.; Kononenko, O.; Kooijman, P.; Korol, Ie.; Korzhavina, I. A.; Kotański, A.; Kötz, U.; Kowalski, H.; Kuprash, O.; Kuze, M.; Lee, A.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Ling, T. Y.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Magill, S.; Makarenko, I.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Martin, J. F.; Mastroberardino, A.; Mattingly, M. C. K.; Melzer-Pellmann, I.-A.; Mergelmeyer, S.; Miglioranzi, S.; Mohamad Idris, F.; Monaco, V.; Montanari, A.; Morris, J. D.; Mujkic, K.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Nigro, A.; Ning, Y.; Nobe, T.; Notz, D.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Olkiewicz, K.; Onishchuk, Yu.; Papageorgiu, K.; Parenti, A.; Paul, E.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perlański, W.; Perrey, H.; Piotrzkowski, K.; Pluciński, P.; Pokrovskiy, N. S.; Polini, A.; Proskuryakov, A. S.; Przybycień, M.; Raval, A.; Reeder, D. D.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Robertson, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Sacchi, R.; Samson, U.; Sartorelli, G.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schneekloth, U.; Schönberg, V.; Schörner-Sadenius, T.; Schwartz, J.; Sciulli, F.; Shcheglova, L. M.; Shehzadi, R.; Shimizu, S.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Smith, W. H.; Sola, V.; Solano, A.; Son, D.; Sosnovtsev, V.; Spiridonov, A.; Stadie, H.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stopa, P.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tapper, A. D.; Tassi, E.; Terrón, J.; Theedt, T.; Tiecke, H.; Tokushuku, K.; Tomaszewska, J.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Vázquez, M.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Walczak, R.; Wan Abdullah, W. A. T.; Whitmore, J. J.; Wichmann, K.; Wiggers, L.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Yagües-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Zabiegalov, O.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zeuner, W.; Zhautykov, B. O.; Zhmak, N.; Zichichi, A.; Zolkapli, Z.; Zotkin, D. S.

    2013-03-01

    Measurements of neutral current cross sections for deep inelastic scattering in e+p collisions at HERA with a longitudinally polarized positron beam are presented. The single-differential cross-sections dσ/dQ2, dσ/dx and dσ/dy and the reduced cross section σ˜ are measured in the kinematic region Q2>185GeV2 and y<0.9, where Q2 is the four-momentum transfer squared, x the Bjorken scaling variable and y the inelasticity of the interaction. The measurements are performed separately for positively and negatively polarized positron beams. The measurements are based on an integrated luminosity of 135.5pb-1 collected with the ZEUS detector in 2006 and 2007 at a center-of-mass energy of 318 GeV. The structure functions F˜3 and F3γZ are determined by combining the e+p results presented in this paper with previously published e-p neutral current results. The asymmetry parameter A+ is used to demonstrate the parity violation predicted in electroweak interactions. The measurements are well described by the predictions of the Standard Model.

  11. Pion in deep inelastic scattering

    SciTech Connect

    Povh, B.

    2008-10-13

    The forward neutron production in the ep collisions at 300 GeV measured by the H1 and ZEUS Collaborations at DESY has been used to estimate the total probability for the proton fluctuation into n{pi}{sup +} and p{pi}{sup 0}. The probability found is on the order of the 30%. This number is compared with the numbers of obtained for the probability of quark fluctuation into {pi}{sup +} from several alternative DIS processes (Gottfried sum rule, polarized structure function) and the axial-vector coupling constant, where the pion fluctuation is believed to play an important role.

  12. Quantum Chromodynamics and Deep Inelastic Scattering

    NASA Astrophysics Data System (ADS)

    Ellis, R. Keith

    2016-10-01

    This article first describes the parton model which was the precursor of the QCD description of hard scattering processes. After the discovery of QCD and asymptotic freedom, the first successful applications were to Deep Inelastic lepton-hadron scattering. The subsequent application of QCD to processes with two initial state hadrons required the understanding and proof of factorization. To take the fledgling theory and turn it into the robust calculational engine it has become today, required a number of technical and conceptual developments which will be described. Prospects for higher loop calculations are also reviewed.

  13. Deep inelastic neutron scattering in condensed hydrogen

    NASA Astrophysics Data System (ADS)

    Bafile, Ubaldo; Celli, Milva; Zoppi, Marco

    1996-02-01

    The neutron cross-section of molecular hydrogen that is measured by deep inelastic neutron scattering (DINS) is compared with two distinct models. One is a generalization of the molecular Young and Koppel model (1964) that takes into account the modification to the translational kinetic energy that is induced by quantum effects. The second model assumes a free particle wave function for the final state of the proton (C. Andreani et al., 1995). The comparison between these two models, and with the experimental results, provides information on the crossover between the molecular and atomic regime of hydrogen in DINS.

  14. Nuclear PDFs from neutrino deep inelastic scattering

    SciTech Connect

    I. Schienbein; J. Y. Yu; C. Keppel; J. G. Morfin; F. Olness; J.F. Owens

    2007-11-13

    We study nuclear effects in charged current deep inelastic neutrino--iron scattering in the framework of a chi^2-analysis of parton distribution functions. We extract a set of iron PDFs and show that under reasonable assumptions it is possible to constrain the valence, light sea and strange quark distributions. We compare our results with nuclear parton distribution functions from the literature and find good agreement. Our iron PDFs are used to compute nuclear correction factors which are required in global analyses of free nucleon PDFs.

  15. Deep inelastic scattering in conformal QCD

    NASA Astrophysics Data System (ADS)

    Cornalba, Lorenzo; Costa, Miguel S.; Penedones, João

    2010-03-01

    We consider the Regge limit of a CFT correlation function of two vector and two scalar operators, as appropriate to study small-x deep inelastic scattering in mathcal{N} = 4 SYM or in QCD assuming approximate conformal symmetry. After clarifying the nature of the Regge limit for a CFT correlator, we use its conformal partial wave expansion to obtain an impact parameter representation encoding the exchange of a spin j Reggeon for any value of the coupling constant. The CFT impact parameter space is the three-dimensional hyperbolic space H 3, which is the impact parameter space for high energy scattering in the dual AdS space. We determine the small-x structure functions associated to the exchange of a Reggeon. We discuss unitarization from the point of view of scattering in AdS and comment on the validity of the eikonal approximation. We then focus on the weak coupling limit of the theory where the amplitude is dominated by the exchange of the BFKL pomeron. Conformal invariance fixes the form of the vector impact factor and its decomposition in transverse spin 0 and spin 2 components. Our formalism reproduces exactly the general results predict by the Regge theory, both for a scalar target and for γ* - γ* scattering. We compute current impact factors for the specific examples of mathcal{N} = 4 SYM and QCD, obtaining very simple results. In the case of the R-current of mathcal{N} = 4 SYM, we show that the transverse spin 2 component vanishes. We conjecture that the impact factors of all chiral primary operators of mathcal{N} = 4 SYM only have components with 0 transverse spin.

  16. Deep Inelastic Scattering on Ultracold Gases

    NASA Astrophysics Data System (ADS)

    Hofmann, Johannes; Zwerger, Wilhelm

    2017-01-01

    We discuss Bragg scattering on both Bose and Fermi gases with strong short-range interactions in the deep inelastic regime of large wave vector transfer q , where the dynamic structure factor is dominated by a resonance near the free-particle energy ℏω =ɛq=ℏ2q2/2 m . Using a systematic short-distance expansion, the structure factor at high momentum is shown to exhibit a nontrivial dependence on frequency characterized by two separate scaling regimes. First, for frequencies that differ from the single-particle energy by terms of order O (q ) (i.e., small deviations compared to the single-particle energy), the dynamic structure factor is described by the impulse approximation of Hohenberg and Platzman. Second, deviations of order O (q2) (i.e., of the same order or larger than the single-particle energy) are described by the operator product expansion, with a universal crossover connecting both regimes. The scaling is consistent with the leading asymptotics for a number of sum rules in the large momentum limit. Furthermore, we derive an exact expression for the shift and width of the single-particle peak at large momentum due to interactions, thus extending a result by Beliaev [J. Exp. Theor. Phys. 7, 299 (1958)] for the low-density Bose gas to arbitrary values of the scattering length a . The shift exhibits a maximum around q a ≃1 , which is connected with a maximum in the static structure factor due to strong short-range correlations. For Bose gases with moderate interaction strengths, the theoretically predicted shift is consistent with the value observed by Papp et al. [Phys. Rev. Lett. 101, 135301 (2008), 10.1103/PhysRevLett.101.135301]. Finally, we develop a diagrammatic theory for the dynamic structure factor which accounts for the correlations beyond Bogoliubov theory. It covers the full range of momenta and frequencies and provides an explicit example for the emergence of asymptotic scaling at large momentum.

  17. Measurement of the cross section ratio σψ(2S)/σJ/ψ(1S) in deep inelastic exclusive ep scattering at HERA

    NASA Astrophysics Data System (ADS)

    Ciborowsk, Jacek

    2016-11-01

    The exclusive deep inelastic electroproduction of ψ (2S) and J/ψ (1S) at an ep centre-of-mass energy of 317 GeV has been studied with the ZEUS detector at HERA in the kinematic range 2 < Q2 < 80 GeV2, 30 < W < 210 GeV and |t| < 1 GeV2, where Q2 is the photon virtuality, W is the photon-proton centre-of-mass energy and t is the squared four-momentum transfer at the proton vertex. The data for 2 < Q2 < 5 GeV2 were taken in the HERAI running period and correspond to an integrated luminosity of 114 pb-1. The data for 5 < Q2 < 80 GeV2 are from both HERAI and HERAII periods and correspond to an integrated luminosity of 468 pb-1. The decay modes analysed were μ+ μ- and J/ψ (1S) π+ π- for the ψ (2S) and μ+ μ- for the J/ψ(1S). The cross-section ratio σψ(2S)/σJ/ψ(1S) has been measured as a function of Q2; W and t. The results are compared to predictions of QCD-inspired models of exclusive vector-meson production.

  18. Measurement of the cross-section ratio σψ(2S)/σJ/ψ(1S) in deep inelastic exclusive ep scattering at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Antonelli, S.; Aushev, V.; Aushev, Y.; Behnke, O.; Behrens, U.; Bertolin, A.; Bloch, I.; Boos, E. G.; Borras, K.; Brock, I.; Brook, N. H.; Brugnera, R.; Bruni, A.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; Dementiev, R. K.; Devenish, R. C. E.; Dolinska, G.; Dusini, S.; Figiel, J.; Foster, B.; Gach, G.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Jomhari, N. Z.; Kadenko, I.; Kananov, S.; Karshon, U.; Kaur, M.; Kaur, P.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kotański, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Krupa, B.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Makarenko, I.; Malka, J.; Mergelmeyer, S.; Mohamad Idris, F.; Mohammad Nasir, N.; Myronenko, V.; Nagano, K.; Nobe, T.; Notz, D.; Nowak, R. J.; Onishchuk, Yu.; Paul, E.; Perlański, W.; Pokrovskiy, N. S.; Przybycień, M.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schneekloth, U.; Schörner-Sadenius, T.; Shcheglova, L. M.; Shevchenko, R.; Shkola, O.; Shyrma, Yu.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Solano, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zhmak, N.; Zotkin, D. S.

    2016-08-01

    The exclusive deep inelastic electroproduction of ψ (2 S) and J / ψ (1 S) at an ep centre-of-mass energy of 317 GeV has been studied with the ZEUS detector at HERA in the kinematic range 2

  19. Response functions for deep inelastic scattering from 40Ca

    NASA Astrophysics Data System (ADS)

    Deady, M.; Williamson, C. F.; Wong, J.; Zimmerman, P. D.; Blatchley, C.; Finn, J. M.; Lerose, J.; Sioshansi, P.; Altemus, R.; McCarthy, J. S.; Whitney, R. R.

    1983-08-01

    Deep inelastic electron scattering cross sections have been measured from 40Ca at energies between 100 and 375 MeV and at scattering angles of 90° and 140°. Longitudinal and transverse response functions at three-vector momentum transfers of 330, 370, and 410 MeV/c were extracted from these data using a Rosenbluth separation. The integrated longitudinal response functions for the three momentum transfers are found to have, respectively, 65%, 75%, and 90% of the longitudinal strength predicted by the Fermi gas model. NUCLEAR REACTIONS Deep inelastic electron scattering from 40Ca, extracted transverse and longitudinal response functions.

  20. Deep-inelastic muon scattering from nuclei with hadron detection

    SciTech Connect

    Geesaman, D.; Jackson, H.; Kaufman, S.

    1995-08-01

    Deep-inelastic lepton scattering from nuclei provides a direct look at the quark structure of nuclear matter. These reactions revealed the first convincing evidence that the structure of nucleons is modified in the nuclear medium and had profound implications on the understanding of nuclear dynamics. FNAL experiment E665, using the 490-GeV muon beams at Fermi National Accelerator Laboratory, provides new information on the nuclear effects on nucleon properties by studying deep-inelastic muon scattering with coincident hadron detection. The high beam energy makes the experiment particularly suited to the study of the region of x < 0.1 (where x is the fraction of the momentum of the nucleon carried by the struck quark in the infinite momentum frame), and total center-of-mass hadronic energy > 25 GeV, where hard QCD processes are expected to become evident and there are little data from other deep-inelastic measurements.

  1. Inclusive Deep Inelastic Scattering at HERA

    SciTech Connect

    Newman, Paul

    2011-07-15

    Recent inclusive charged and neutral current scattering data from HERA are presented. Emphasis is placed on the resulting constraints on the proton parton densities and on the influence of low x proton structure on diffraction.

  2. NLO QCD corrections to graviton induced deep inelastic scattering

    NASA Astrophysics Data System (ADS)

    Stirling, W. J.; Vryonidou, E.

    2011-06-01

    We consider Next-to-Leading-Order QCD corrections to ADD graviton exchange relevant for Deep Inelastic Scattering experiments. We calculate the relevant NLO structure functions by calculating the virtual and real corrections for a set of graviton interaction diagrams, demonstrating the expected cancellation of the UV and IR divergences. We compare the NLO and LO results at the centre-of-mass energy relevant to HERA experiments as well as for the proposed higher energy lepton-proton collider, LHeC, which has a higher fundamental scale reach.

  3. Deep inelastic electron scattering from iron 56 and other tails

    NASA Astrophysics Data System (ADS)

    Altemus, R. M.

    1980-03-01

    Deep inelastic electron scattering data on iron 56 are presented for angles of 160 degrees, 140 degrees and 90 degrees and at incident energies ranging from 372 MeV to 100 MeV. Radiative contributions from real target bremsstrahlung and from the continuum are included. The data were separated into longitudinal, Sl(q, omega) and transverse, ST(q, omega) response functions. A Coulomb sum rule for constant q is formulated and compared with an independent particle model (Fermi gas). Short range correlations, finite size effects, effective momentum transfer and final state interactions are considered in an attempt to explain the observed discrepancies.

  4. Neutrino-Nucleon Deep Inelastic Scattering in MINERvA

    NASA Astrophysics Data System (ADS)

    Norrick, Anne; Minerva Collaboration

    2015-04-01

    Neutrino-Nucleon Deep Inelastic Scattering (DIS) events provide a probe into the structure of the nucleus that cannot be accessed via charged lepton-nucleon interactions. The MINERvA experiment is stationed in the Neutrinos from the Main Injector (NuMI) beam line at Fermi National Accelerator Laboratory. The projected sensitivity of nuclear structure function analyses using MINERvA's suite of nuclear targets (C, CH, Fe and Pb) in the upgraded 6 GeV neutrino energy NuMI beam will be explored, and their impact discussed.

  5. Measurement of D*± production in deep inelastic scattering at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Bartosik, N.; Bartsch, D.; Basile, M.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Bertolin, A.; Bhadra, S.; Bindi, M.; Blohm, C.; Bokhonov, V.; Bold, T.; Boos, E. G.; Borras, K.; Boscherini, D.; Bot, D.; Brock, I.; Brownson, E.; Brugnera, R.; Brümmer, N.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bussey, P. J.; Bylsma, B.; Caldwell, A.; Capua, M.; Carlin, R.; Catterall, C. D.; Chekanov, S.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; D'Agostini, G.; Dal Corso, F.; del Peso, J.; Dementiev, R. K.; De Pasquale, S.; Derrick, M.; Devenish, R. C. E.; Dobur, D.; Dolgoshein, B. A.; Dolinska, G.; Doyle, A. T.; Drugakov, V.; Durkin, L. S.; Dusini, S.; Eisenberg, Y.; Ermolov, P. F.; Eskreys, A.; Fang, S.; Fazio, S.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Foster, B.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gialas, I.; Gizhko, A.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Gogota, O.; Golubkov, Yu. A.; Göttlicher, P.; Grabowska-Bold, I.; Grebenyuk, J.; Gregor, I.; Grigorescu, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Gwenlan, C.; Haas, T.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Hilger, E.; Hochman, D.; Hori, R.; Hüttmann, A.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Iudin, A.; Jakob, H.-P.; Januschek, F.; Jones, T. W.; Jüngst, M.; Kadenko, I.; Kahle, B.; Kananov, S.; Kanno, T.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, M.; Kaur, P.; Keramidas, A.; Khein, L. A.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, U.; Koffeman, E.; Kondrashova, N.; Kononenko, O.; Kooijman, P.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Lee, A.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Ling, T. Y.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Magill, S.; Makarenko, I.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Martin, J. F.; Mastroberardino, A.; Mattingly, M. C. K.; Melzer-Pellmann, I.-A.; Mergelmeyer, S.; Miglioranzi, S.; Mohamad Idris, F.; Monaco, V.; Montanari, A.; Morris, J. D.; Mujkic, K.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Nigro, A.; Ning, Y.; Nobe, T.; Notz, D.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Olkiewicz, K.; Onishchuk, Yu.; Papageorgiu, K.; Parenti, A.; Paul, E.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perlanski, W.; Perrey, H.; Piotrzkowski, K.; Plucinski, P.; Pokrovskiy, N. S.; Polini, A.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Reeder, D. D.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Robertson, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Sacchi, R.; Samson, U.; Sartorelli, G.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schneekloth, U.; Schönberg, V.; Schörner-Sadenius, T.; Schwartz, J.; Sciulli, F.; Shcheglova, L. M.; Shehzadi, R.; Shimizu, S.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Smith, W. H.; Sola, V.; Solano, A.; Son, D.; Sosnovtsev, V.; Spiridonov, A.; Stadie, H.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stopa, P.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tapper, A. D.; Tassi, E.; Terrón, J.; Theedt, T.; Tiecke, H.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Vázquez, M.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Walczak, R.; Wan Abdullah, W. A. T.; Whitmore, J. J.; Wichmann, K.; Wiggers, L.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Yagües-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zeuner, W.; Zhautykov, B. O.; Zhmak, N.; Zichichi, A.; Zolkapli, Z.; Zotkin, D. S.

    2013-05-01

    The production of D *± mesons in deep inelastic ep scattering has been measured for exchanged photon virtualities 5 < Q 2 < 1000 GeV2, using an integrated luminosity of 363 pb-1 with the ZEUS detector at HERA. Differential cross sections have been measured and compared to next-to-leading-order QCD calculations. The cross-sections are used to extract the charm contribution to the proton structure functions, expressed in terms of the reduced charm cross section, σ_{red}^{{coverline{c}}} . Theoretical calculations based on fits to inclusive HERA data are compared to the results.

  6. Bessel-Weighted Asymmetries in Semi Inclusive Deep Inelastic Scattering

    SciTech Connect

    D. Boer, L. Gamberg, B.U. Musch, A. Prokudin

    2011-10-01

    The concept of weighted asymmetries is revisited for semi-inclusive deep inelastic scattering. We consider the cross section in Fourier space, conjugate to the outgoing hadron's transverse momentum, where convolutions of transverse momentum dependent parton distribution functions and fragmentation functions become simple products. Individual asymmetric terms in the cross section can be projected out by means of a generalized set of weights involving Bessel functions. Advantages of employing these Bessel weights are that they suppress (divergent) contributions from high transverse momentum and that soft factors cancel in (Bessel-) weighted asymmetries. Also, the resulting compact expressions immediately connect to previous work on evolution equations for transverse momentum dependent parton distribution and fragmentation functions and to quantities accessible in lattice QCD. Bessel weighted asymmetries are thus model independent observables that augment the description and our understanding of correlations of spin and momentum in nucleon structure.

  7. Photon-jet cross sections in deep-inelastic scattering

    NASA Astrophysics Data System (ADS)

    Aurenche, P.; Fontannaz, M.

    2015-02-01

    We present the complete next-to-leading order calculation of isolated prompt photon production in association with a jet in deep-inelastic scattering. The calculation involves, direct, resolved, and fragmentation contributions. It is shown that defining the transverse momenta in the proton virtual-photon frame (CM), as usually done, or in the laboratory frame, as done in some experiments, is not equivalent and leads to important differences concerning the perturbative approach. In fact, using the latter frame may preclude, under certain conditions, the calculation of the next-to-leading order correction to the important resolved component. A comparison with the latest ZEUS data is performed and good agreement is found in the perturbatively stable regions.

  8. New measurement of inclusive deep inelastic scattering cross sections at HERA

    NASA Astrophysics Data System (ADS)

    Picuric, Ivana

    2016-03-01

    A combined measurement is presented of all inclusive deep inelastic cross sections measured by the H1 and ZEUS collaborations in neutral and charged current unpolarised e±p scattering at HERA. The H1 and ZEUS collaborations collected total integrated luminosities of approximately 500 pb-1 each, divided about equally between e+p and e-p scattering. They include data taken at electron (positron) beam energy of 27.5 GeV and proton beam energies of 920, 820, 575 and 460 GeV corresponding to centre-of-mass energy of 320, 300, 251 and 225 GeV respectively. This enabled the two collaborations to explore a large phase space in Bjorken x and negative four-momentum-transfer squared, Q2. The combination method takes the correlations of the systematic uncertainties into account, resulting in improved accuracy.

  9. Self Organizing Maps for use in Deep Inelastic Scattering

    NASA Astrophysics Data System (ADS)

    Askanazi, Evan

    2015-04-01

    Self Organizing Maps are a type of artificial neural network that has been proven to be particularly useful in solving complex problems in neural biology, engineering, robotics and physics. We are attempting to use the Self Organizing Map to solve problems and probe phenomenological patterns in subatomic physics, specifically in Deep Inelastic Scattering (DIS). In DIS there is a cross section in electron hadron scattering that is dependent on the momentum fraction x of the partons in the hadron and the momentum transfer of the virtual photon exchanged. There is a soft cross part of this cross section that currently can only be found through experimentation; this soft part is comprised of Structure Functions which in turn are comprised of the Parton Distribution Functions (PDFs). We aim to use the Self Organizing Process, or SOP, to take theoretical models of these PDFs and fit it to the previous, known data. The SOP will also be used to probe the behavior of the PDFs in particular at large x values, in order to observe how they congregate. The ability of the SOPto take multidimensional data and convert it into two dimensional output is anticipated to be particularly useful in achieving this aim.

  10. QCD analysis of neutrino charged current structure function F2 in deep inelastic scattering

    NASA Technical Reports Server (NTRS)

    Saleem, M.; Aleem, F.

    1985-01-01

    An analytic expression for the neutrino charged current structure function F sub 2 (x, Q sup 2) in deep inelastic scattering, consistent with quantum chromodynamics, is proposed. The calculated results are in good agreement with experiment.

  11. Precise QCD Predictions for the Production of Dijet Final States in Deep Inelastic Scattering.

    PubMed

    Currie, James; Gehrmann, Thomas; Niehues, Jan

    2016-07-22

    The production of two-jet final states in deep inelastic scattering is an important QCD precision observable. We compute it for the first time to next-to-next-to-leading order (NNLO) in perturbative QCD. Our calculation is fully differential in the lepton and jet variables and allows one to impose cuts on the jets in both the laboratory and the Breit frame. We observe that the NNLO corrections are moderate in size, except at kinematical edges, and that their inclusion leads to a substantial reduction of the scale variation uncertainty on the predictions. Our results will enable the inclusion of deep inelastic dijet data in precision phenomenology studies.

  12. Open charm production in deep inelastic scattering at next-to-leading order at HERA.

    SciTech Connect

    Harris, B. W.

    1999-09-20

    An introduction and overview of charm production in deep inelastic scattering at HERA is given. The existing next-to-leading order perturbative QCD calculations are then reviewed, and key results are summarized. Finally, comparisons are made with the most recent HERA data, and unresolved issues are highlighted.

  13. Measurement of the diffractive structure function in deep inelastic scattering at HERA

    NASA Astrophysics Data System (ADS)

    Derrick, M.; Krakauer, D.; Magill, S.; Mikunas, D.; Musgrave, B.; Repond, J.; Stanek, R.; Talaga, R. L.; Zhang, H.; Ayad, R.; Bari, G.; Basile, M.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Bruni, P.; Cara Romeo, G.; Castellini, G.; Chiarini, M.; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; Gialas, I.; Giusti, P.; Iacobucci, G.; Laurenti, G.; Levi, G.; Margotti, A.; Massam, T.; Nania, R.; Nemoz, C.; Palmonari, F.; Polini, A.; Sartorelli, G.; Timellini, R.; Zamora Garcia, Y.; Zichichi, A.; Bargende, A.; Crittenden, J.; Desch, K.; Diekmann, B.; Doeker, T.; Eckert, M.; Feld, L.; Frey, A.; Geerts, M.; Geitz, G.; Grothe, M.; Hartmann, H.; Heinloth, H.; Hilger, E.; Jakob, H.-P.; Katz, U. F.; Mari, S. M.; Mass, A.; Mengel, S.; Mollen, J.; Paul, E.; Rembser, Ch.; Schramm, D.; Stamm, J.; Wedemeyer, R.; Campbell-Robson, S.; Cassidy, A.; Dyce, N.; Foster, B.; George, S.; Gilmore, R.; Heath, G. P.; Heath, H. F.; Llewellyn, T. J.; Morgado, C. J. S.; Norman, D. J. P.; O'Mara, J. A.; Tapper, R. J.; Wilson, S. S.; Yoshida, R.; Rau, R. R.; Arneodo, M.; Capua, M.; Garfagnini, A.; Iannotti, L.; Schioppa, M.; Susinno, G.; Bernstein, A.; Caldwell, A.; Cartiglia, N.; Parsons, J. A.; Ritz, S.; Sciulli, F.; Straub, P. B.; Wai, L.; Yang, S.; Zhu, Q.; Borzemski, P.; Chwastowski, J.; Eskreys, A.; Piotrzkowski, K.; Zachara, M.; Zawiejski, L.; Adamczyk, L.; Bednarek, B.; Jeleń, K.; Kisielewska, D.; Kowalski, T.; Rulikowska-Zarębska, E.; Suszycki, L.; Zając, J.; Kotański, A.; Przybycień, M.; Bauerdick, L. A. T.; Behrens, U.; Beier, H.; Bienlein, J. K.; Coldewey, C.; Deppe, O.; Desler, K.; Drews, G.; Flasiński, M.; Gilkinson, D. J.; Glasman, C.; Göttlicher, P.; Große-Knetter, J.; Gutjahr, B.; Haas, T.; Hain, W.; Hasell, D.; Heßling, H.; Iga, Y.; Joos, P.; Kasemann, M.; Klanner, R.; Koch, W.; Köpke, L.; Kötz, U.; Kowalski, H.; Labs, J.; Ladage, A.; Löhr, B.; Löwe, M.; Lüke, D.; Mainusch, J.; Mańczak, O.; Monteiro, T.; Ng, J. S. T.; Nickel, S.; Notz, D.; Ohrenberg, K.; Roco, M.; Rohde, M.; Roldán, J.; Schneekloth, U.; Schulz, W.; Selonke, F.; Stiliaris, E.; Surrow, B.; Voß, T.; Westphal, D.; Wolf, G.; Youngman, C.; Zhou, J. F.; Grabosch, H. J.; Kharchilava, A.; Leich, A.; Mattingly, M. C. K.; Meyer, A.; Schlenstedt, S.; Wulff, N.; Barbagli, G.; Pelfer, P.; Anzivino, G.; Maccarrone, G.; de Pasquale, S.; Votano, L.; Bamberger, A.; Eisenhardt, S.; Freidhof, A.; Söldner-Rembold, S.; Schroeder, J.; Trefzger, T.; Brook, N. H.; Bussey, P. J.; Doyle, A. T.; Fleck, J. I.; Saxon, D. H.; Utley, M. L.; Wilson, A. S.; Dannemann, A.; Holm, U.; Horstmann, D.; Neumann, T.; Sinkus, R.; Wick, K.; Badura, E.; Burow, B. D.; Hagge, L.; Lohrmann, E.; Milewski, J.; Nakahata, M.; Pavel, N.; Poelz, G.; Schott, W.; Zetsche, F.; Bacon, T. C.; Butterworth, I.; Gallo, E.; Harris, V. L.; Hung, B. Y. H.; Long, K. R.; Miller, D. B.; Morawitz, P. P. O.; Prinias, A.; Sedgbeer, J. K.; Whitfield, A. F.; Mallik, U.; McCliment, E.; Wang, M. Z.; Wang, S. M.; Wu, J. T.; Zhang, Y.; Cloth, P.; Filges, D.; An, S. H.; Hong, S. M.; Nam, S. W.; Park, S. K.; Suh, M. H.; Yon, S. H.; Imlay, R.; Kartik, S.; Kim, H.-J.; McNeil, R. R.; Metcalf, W.; Nadendla, V. K.; Barreiro, F.; Cases, G.; Fernandez, J. P.; Graciani, R.; Hernández, J. M.; Hervás, L.; Labarga, L.; Martinez, M.; Del Peso, J.; Puga, J.; Terron, J.; de Trocóniz, J. F.; Smith, G. R.; Corriveau, F.; Hanna, D. S.; Hartmann, J.; Hung, L. W.; Lim, J. N.; Matthews, C. G.; Patel, P. M.; Sinclair, L. E.; Stairs, D. G.; St. Laurent, M.; Ullmann, R.; Zacek, G.; Bashkirov, V.; Dolgoshein, B. A.; Stifutkin, A.; Bashindzhagyan, G. L.; Ermolov, P. F.; Gladilin, L. K.; Golubkov, Yu. A.; Kobrin, V. D.; Korzhavina, I. A.; Kuzmin, V. A.; Lukina, O. Yu.; Proskuryakov, A. S.; Savin, A. A.; Shcheglova, L. M.; Solomin, A. N.; Zotov, N. P.; Botje, M.; Chlebana, F.; Dake, A.; Engelen, J.; de Kamps, M.; Kooijman, P.; Kruse, A.; Tiecke, H.; Verkerke, W.; Vreeswijk, M.; Wiggers, L.; de Wolf, E.; van Woudenberg, R.; Acosta, D.; Bylsma, B.; Durkin, L. S.; Honscheid, K.; Li, C.; Ling, T. Y.; McLean, K. W.; Murray, W. N.; Park, I. H.; Romanowski, T. A.; Seidlein, R.; Bailey, D. S.; Byrne, A.; Cashmore, R. J.; Cooper-Sarkar, A. M.; Devenish, R. C. E.; Harnew, N.; Lancaster, M.; Lindemann, L.; McFall, J. D.; Nath, C.; Noyes, V. A.; Quadt, A.; Tickner, J. R.; Uijterwaal, H.; Walczak, R.; Waters, D. S.; Wilson, F. F.; Yip, T.; Abbiendi, G.; Bertolin, A.; Brugnera, R.; Carlin, R.; Dal Corso, F.; de Giorgi, M.; Dosselli, U.; Limentani, S.; Morandin, M.; Posocco, M.; Stanco, L.; Stroili, R.; Voci, C.; Bulmahn, J.; Butterworth, J. M.; Feild, R. G.; Oh, B. Y.; Whitmore, J. J.; D'Agostini, G.; Marini, G.; Nigro, A.; Tassi, E.; Hart, J. C.; McCubbin, N. A.; Prytz, K.; Shah, T. P.; Short, T. L.; Barberis, E.; Dubbs, T.; Heusch, C.; van Hook, M.; Hubbard, B.; Lockman, W.; Rahn, J. T.; Sadrozinski, H. F.-W.; Seiden, A.; Biltzinger, J.; Seifert, R. J.; Schwarzer, O.; Walenta, A. H.; Zech, G.; Abramowicz, H.; Briskin, G.; Dagan, S.; Levy, A.; Hasegawa, T.; Hazumi, M.; Ishii, T.; Kuze, M.; Mine, S.; Nagasawa, Y.; Nakao, M.; Suzuki, I.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Chiba, M.; Hamatsu, R.; Hirose, T.; Homma, K.; Kitamura, S.; Nakamitsu, Y.; Yamauchi, K.; Cirio, R.; Costa, M.; Ferrero, M. I.; Lamberti, L.; Maselli, S.; Peroni, C.; Sacchi, R.; Solano, A.; Staiano, A.; Dardo, M.; Bailey, D. C.; Bandyopadhyay, D.; Benard, F.; Brkic, M.; Crombie, M. B.; Gingrich, D. M.; Hartner, G. F.; Joo, K. K.; Levman, G. M.; Martin, J. F.; Orr, R. S.; Sampson, C. R.; Teuscher, R. J.; Catterall, C. D.; Jones, T. W.; Kaziewicz, P. B.; Lane, J. B.; Saunders, R. L.; Shulman, J.; Blankenship, K.; Lu, B.; Mo, L. W.; Bogusz, W.; Charchula, K.; Ciborowski, J.; Gajewski, J.; Grzelak, G.; Kasprzak, M.; Krzyżanowski, M.; Muchorowski, K.; Nowak, R. J.; Pawlak, J. M.; Tymieniecka, T.; Wróblewski, A. K.; Zakrzewski, J. A.; Żarnecki, A. F.; Adamus, M.; Eisenberg, Y.; Karshon, U.; Revel, D.; Zer-Zion, D.; Ali, I.; Badgett, W. F.; Behrens, B.; Dasu, S.; Fordham, C.; Foudas, C.; Goussiou, A.; Loveless, R. J.; Reeder, D. D.; Silverstein, S.; Smith, W. H.; Vaiciulis, A.; Wodarczyk, M.; Tsurugai, T.; Bhadra, S.; Cardy, M. L.; Fagerstroem, C.-P.; Frisken, W. R.; Furutani, K. M.; Khakzad, M.; Schmidke, W. B.

    1995-12-01

    This paper presents an analysis of the inclusive properties of diffractive deep inelastic scattering events produced in ep interactions at HERA. The events are characterised by a rapidity gap between the outgoing proton system and the remaining hadronic system. Inclusive distributions are presented and compared with Monte Carlo models for diffractive processes. The data are consistent with models where the pomeron structure function has a hard and a soft contribution. The diffractive structure function is measured as a function of x ℙ, the momentum fraction lost by the proton, of β, the momentum fraction of the struck quark with respect to x ℙ, and of Q 2 in the range 6.3·10-4< x ℙ <10-2, 0.1<β<0.8 and 8< Q 2<100 GeV2. The dependence is consistent with the form x ℙ where a=1.30±0.08(stat) {-0.14/+0.08} (sys) in all bins of β and Q 2. In the measured Q 2 range, the diffractive structure function approximately scales with Q 2 at fixed β. In an Ingelman-Schlein type model, where commonly used pomeron flux factor normalisations are assumed, it is found that the quarks within the pomeron do not saturate the momentum sum rule.

  14. Two Photon Exchange in Quasi-elastic and Deep-inelastic Scattering

    SciTech Connect

    Averett, Todd D.; Katich, Joseph; Zhao Bo

    2011-10-24

    In this paper, I present an overview and preliminary results from three experiments at Jefferson Lab that were recently completed using a {sup 3}He gas target with polarization oriented normal to the scattering plane of unpolarized incident electrons. A target single spin asymmetry was formed by periodically flipping the direction of the target spin. In the reaction {up_arrow}{sup 3}He(e,e'), the Born contribution is expected to be zero, giving direct sensitivity to two photon exchange. This asymmetry was measured in the quasi-elastic and deep-inelastic regimes with 0.1 < Q{sup 2} < 1.0 GeV{sup 2}. The asymmetry is predicted to decrease by two-orders of magnitude for deep-inelastic versus quasi-elastic scattering. Preliminary results from these experiments will be presented.

  15. Production of Ξ- in deep inelastic scattering with ZEUS detector at HERA

    NASA Astrophysics Data System (ADS)

    Nasir, N. Mohammad; Wan Abdullah, W. A. T.

    2016-01-01

    In this paper, we discussed about the possible mechanism on how strange baryon are being produced. The discovery of strange quarks in cosmic rays before the quarks model being proposed makes the searches become more interesting, as it has long lifetimes. The inclusive deep inelastic scattering of Ξ- has been studied in electron-proton collisions with ZEUS detector at HERA. We also studied HERA kinematics and phase space.

  16. Production of Ξ{sup −} in deep inelastic scattering with ZEUS detector at HERA

    SciTech Connect

    Nasir, N. Mohammad Wan Abdullah, W. A. T.

    2016-01-22

    In this paper, we discussed about the possible mechanism on how strange baryon are being produced. The discovery of strange quarks in cosmic rays before the quarks model being proposed makes the searches become more interesting, as it has long lifetimes. The inclusive deep inelastic scattering of Ξ{sup −} has been studied in electron-proton collisions with ZEUS detector at HERA. We also studied HERA kinematics and phase space.

  17. Measurements of transverse momentum in semi-inclusive deep-inelastic scattering at CLAS

    SciTech Connect

    K.A. Griffioen

    2012-12-01

    With mounting experimental evidence that only a small fraction of the proton's spin comes from the spins of its quarks and gluons, the quest for orbital angular momentum has begun. The parton distributions relevant to this depend on transverse quark momenta. Recent CLAS semi-inclusive deep-inelastic scattering measurements probe these new transverse-momentum-dependent parton distributions using longitudinally polarized beams and targets and detecting {pi}{sup +},{pi}{sup -} and {pi}{sup 0} in the final state.

  18. Multi-jet production rates in deep-inelastic muon-proton scattering

    SciTech Connect

    Salgado, C.W. )

    1992-02-01

    Measurements of forward multi-jet production rates in deep-inelastic muon-proton scattering are presented. Data were taken with a 490 GeV muon beam incident on a hydrogen target. Jets were defined using the JADE jet finding algorithm. The measured rates are presented as function of W, the hadronic center-of-mass energy and the jet resolution parameter, [ital y][sub [ital cut

  19. Toward a QCD analysis of jet rates in deep-inelastic Muon-Proton scattering

    SciTech Connect

    Salgado, C.W.; E665 Collaboration

    1993-08-01

    Measurements of multi-jet production rates in deep-inelastic Muon-Proton scattering at Fermilab-E665 are presented. Jet rates defined by the JADE clustering algorithm are compared to perturbative Quantum chromodynamics (PQCD) and different Monte Carlo model predictions. The applicability of the jet-parton duality hypothesis is studied. We obtain hadronic jet rates which are approximately a factor of two higher than PQCD predictions at the parton level. Possible causes for this discrepancy are discussed.

  20. Test of factorization in diffractive deep inelastic scattering and photoproduction at HERA

    SciTech Connect

    Polifka, Richard

    2015-04-10

    The QCD factorization theorem in diffraction is tested by comparing diffractive jet production data to QCD predictions based on fits to inclusive diffractive cross section data. H1 measured dijet production with a leading proton detected in the Very Forward Proton Spectrometer (VFPS), both in deep-inelastic scattering and in photoproduction. The DIS measurements are complemented by measurements of dijet production with an associated rapidity gap and in a data sample selected with a leading proton in the Forward Proton Spectrometer (FPS)

  1. Transverse response functions in deep inelastic electron scattering for 40Ca, 48Ca, and 56Fe

    NASA Astrophysics Data System (ADS)

    Meziani, Z. E.; Barreau, P.; Bernheim, M.; Morgenstern, J.; Turck-Chieze, S.; Altemus, R.; McCarthy, J.; Orphanos, L. J.; Whitney, R. R.; Capitani, G. P.; de Sanctis, E.; Frullani, S.; Garibaldi, F.

    1985-03-01

    Deep-inelastic inclusive electron-scattering cross sections from 40Ca, 48Ca, and 56Fe have been measured at 60°, 90°, and 140° and at energy transfers including the Δ(3,3) region. The transverse response function in the momentum interval 300 MeV/c<||q-->||<600 MeV/c was extracted by the Rosenbluth prescription. Different theoretical approaches to the quasielastic region are compared to the data. A mass-number scaling is observed.

  2. AdS Black Disk Model for Small-x Deep Inelastic Scattering

    NASA Astrophysics Data System (ADS)

    Cornalba, Lorenzo; Costa, Miguel S.; Penedones, João

    2010-08-01

    Using the approximate conformal invariance of QCD at high energies we consider a simple anti-de Sitter black disk model to describe saturation in deep inelastic scattering. Deep inside saturation the structure functions have the same power law scaling, FT˜FL˜x-ω, where ω is related to the expansion rate of the black disk with energy. Furthermore, the ratio FL/FT is given by the universal value (1+ω)/(3+ω), independently of the target. For γ*-γ* scattering at high energies we obtain explicit expressions and ratios for the total cross sections of transverse and longitudinal photons in terms of the single parameter ω.

  3. Deep Inelastic Scattering results from the first year of HERA operation

    SciTech Connect

    Magill, S.R.

    1993-12-31

    The first year of operation of the HERA electron-proton collider has resulted in Deep Inelastic Scattering (DIS) Physics results from both the H1 and ZEUS experiments. Reported here are the H1 and ZEUS measurements of the proton structure function F{sub 2} at higher Q{sup 2} and lower x than previously reported from fixed target experiments. Also included are the results of QCD studies on hadronic final states and jets, and the observation of high Q{sup 2} charged current events from both experiments. Finally, the observation of events with large rapidity gaps by the ZEUS collaboration is also reported.

  4. Jet production in deep-inelastic muon scattering at 490 GeV

    SciTech Connect

    Melanson, H.L.

    1993-06-01

    Measurements of jet rates in deep-inelastic muon scattering are presented. The JADE algorithm is used to define jets in the kinematic region 9 < W < 33 GeV. Data taken on a proton target are analyzed within the QCD framework, with the goal of extracting [alpha][sub s]. Results on the Q[sup 2] dependence of the average transverse momentum of jets are used to demonstrate the running of the strong coupling constant [alpha][sub s]. In addition, first measurements of the production of jets from heavy nuclei in the region x[sub B[sub j

  5. Study of Σ(1385) and Ξ(1321) hyperon and antihyperon production in deep inelastic muon scattering

    NASA Astrophysics Data System (ADS)

    Adolph, C.; Alekseev, M. G.; Alexakhin, V. Y.; Alexandrov, Y.; Alexeev, G. D.; Amoroso, A.; Austregesilo, A.; Badełek, B.; Balestra, F.; Barth, J.; Baum, G.; Bedfer, Y.; Berlin, A.; Bernhard, J.; Bertini, R.; Bicker, K.; Bieling, J.; Birsa, R.; Bisplinghoff, J.; Bordalo, P.; Bradamante, F.; Braun, C.; Bravar, A.; Bressan, A.; Büchele, M.; Burtin, E.; Capozza, L.; Chiosso, M.; Chung, S. U.; Cicuttin, A.; Crespo, M. L.; Dalla Torre, S.; Dasgupta, S. S.; Dasgupta, S.; Denisov, O. Y.; Donskov, S. V.; Doshita, N.; Duic, V.; Dünnweber, W.; Dziewiecki, M.; Efremov, A.; Elia, C.; Eversheim, P. D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Filin, A.; Finger, M.; Finger, M.; Fischer, H.; Franco, C.; du Fresne von Hohenesche, N.; Friedrich, J. M.; Frolov, V.; Garfagnini, R.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Geyer, R.; Giorgi, M.; Gnesi, I.; Gobbo, B.; Goertz, S.; Grabmüller, S.; Grasso, A.; Grube, B.; Gushterski, R.; Guskov, A.; Guthörl, T.; Haas, F.; von Harrach, D.; Heinsius, F. H.; Herrmann, F.; Heß, C.; Hinterberger, F.; Höppner, C.; Horikawa, N.; d'Hose, N.; Huber, S.; Ishimoto, S.; Ivanshin, Y.; Iwata, T.; Jahn, R.; Jary, V.; Jasinski, P.; Joosten, R.; Kabuß, E.; Kang, D.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Y. A.; Kisselev, Y.; Klein, F.; Klimaszewski, K.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Königsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O.; Krämer, M.; Kroumchtein, Z. V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levorato, S.; Lichtenstadt, J.; Maggiora, A.; Magnon, A.; Makke, N.; Mallot, G. K.; Mann, A.; Marchand, C.; Martin, A.; Marzec, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Y. V.; Miyachi, Y.; Morreale, A.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neubert, S.; Neyret, D.; Nikolaenko, V. I.; Novy, J.; Nowak, W.-D.; Nunes, A. S.; Olshevsky, A. G.; Ostrick, M.; Panknin, R.; Panzieri, D.; Parsamyan, B.; Paul, S.; Piragino, G.; Platchkov, S.; Pochodzalla, J.; Polak, J.; Polyakov, V. A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Reicherz, G.; Rocco, E.; Rodionov, V.; Rondio, E.; Rossiyskaya, N. S.; Ryabchikov, D. I.; Samoylenko, V. D.; Sandacz, A.; Sapozhnikov, M. G.; Sarkar, S.; Savin, I. A.; Sbrizzai, G.; Schiavon, P.; Schill, C.; Schlüter, T.; Schmidt, A.; Schmidt, K.; Schmitt, L.; Schmïden, H.; Schönning, K.; Schopferer, S.; Schott, M.; Shevchenko, O. Y.; Silva, L.; Sinha, L.; Sirtl, S.; Sosio, S.; Sozzi, F.; Srnka, A.; Steiger, L.; Stolarski, M.; Sulc, M.; Sulej, R.; Suzuki, H.; Sznajder, P.; Takekawa, S.; Ter Wolbeek, J.; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Uhl, S.; Uman, I.; Vandenbroucke, M.; Virius, M.; Wang, L.; Weisrock, T.; Wilfert, M.; Windmolders, R.; Wiślicki, W.; Wollny, H.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Zhuravlev, N.; Ziembicki, M.

    2013-10-01

    Large samples of Λ, Σ(1385) and Ξ(1321) hyperons produced in the deep-inelastic muon scattering off a 6LiD target were collected with the COMPASS experimental setup at CERN. The relative yields of Σ(1385)+, Σ(1385)-, , , Ξ(1321)-, and hyperons decaying into were measured. The ratios of heavy-hyperon to Λ and heavy-antihyperon to were found to be in the range 3.8 % to 5.6 % with a relative uncertainty of about 10 %. They were used to tune the parameters relevant for strange particle production of the LEPTO Monte Carlo generator.

  6. Hadron transverse momentum distributions in muon deep inelastic scattering at 160 GeV/ c

    NASA Astrophysics Data System (ADS)

    Adolph, C.; Alekseev, M. G.; Alexakhin, V. Yu.; Alexandrov, Yu.; Alexeev, G. D.; Amoroso, A.; Andrieux, V.; Austregesilo, A.; Badełek, B.; Balestra, F.; Barth, J.; Baum, G.; Bedfer, Y.; Berlin, A.; Bernhard, J.; Bertini, R.; Bicker, K.; Bieling, J.; Birsa, R.; Bisplinghoff, J.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bravar, A.; Bressan, A.; Büchele, M.; Burtin, E.; Capozza, L.; Chiosso, M.; Chung, S. U.; Cicuttin, A.; Crespo, M. L.; Dalla Torre, S.; Dasgupta, S. S.; Dasgupta, S.; Denisov, O. Yu.; Donskov, S. V.; Doshita, N.; Duic, V.; Dünnweber, W.; Dziewiecki, M.; Efremov, A.; Elia, C.; Eversheim, P. D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Filin, A.; Finger, M.; Finger, M.; Fischer, H.; Franco, C.; du Fresne von Hohenesche, N.; Friedrich, J. M.; Frolov, V.; Garfagnini, R.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Geyer, R.; Giorgi, M.; Gnesi, I.; Gobbo, B.; Goertz, S.; Grabmüller, S.; Grasso, A.; Grube, B.; Gushterski, R.; Guskov, A.; Guthörl, T.; Haas, F.; von Harrach, D.; Heinsius, F. H.; Herrmann, F.; Heß, C.; Hinterberger, F.; Höppner, Ch.; Horikawa, N.; d'Hose, N.; Huber, S.; Ishimoto, S.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jary, V.; Jasinski, P.; Joosten, R.; Kabuß, E.; Kang, D.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Yu. A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Königsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O.; Krämer, M.; Kroumchtein, Z. V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levorato, S.; Lichtenstadt, J.; Maggiora, A.; Magnon, A.; Makke, N.; Mallot, G. K.; Mann, A.; Marchand, C.; Martin, A.; Marzec, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Morreale, A.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neubert, S.; Neyret, D.; Nikolaenko, V. I.; Novy, J.; Nowak, W.-D.; Nunes, A. S.; Olshevsky, A. G.; Ostrick, M.; Panknin, R.; Panzieri, D.; Parsamyan, B.; Paul, S.; Piragino, G.; Platchkov, S.; Pochodzalla, J.; Polak, J.; Polyakov, V. A.; Pretz, J.; Quaresma, M.; Quintans, C.; Rajotte, J.-F.; Ramos, S.; Reicherz, G.; Rocco, E.; Rodionov, V.; Rondio, E.; Rossiyskaya, N. S.; Ryabchikov, D. I.; Samoylenko, V. D.; Sandacz, A.; Sapozhnikov, M. G.; Sarkar, S.; Savin, I. A.; Sbrizzai, G.; Schiavon, P.; Schill, C.; Schlüter, T.; Schmidt, A.; Schmidt, K.; Schmitt, L.; Schmïden, H.; Schönning, K.; Schopferer, S.; Schott, M.; Shevchenko, O. Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Sosio, S.; Sozzi, F.; Srnka, A.; Steiger, L.; Stolarski, M.; Sulc, M.; Sulej, R.; Suzuki, H.; Sznajder, P.; Takekawa, S.; Ter Wolbeek, J.; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Uhl, S.; Uman, I.; Vandenbroucke, M.; Virius, M.; Wang, L.; Weisrock, T.; Wilfert, M.; Windmolders, R.; Wiślicki, W.; Wollny, H.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Zhuravlev, N.; Ziembicki, M.

    2013-08-01

    Multiplicities of charged hadrons produced in deep inelastic muon scattering off a 6LiD target have been measured as a function of the DIS variables x Bj , Q 2, W 2 and the final state hadron variables p T and z. The distributions are fitted with a single exponential function at low values of to determine the dependence of on x Bj , Q 2, W 2 and z. The z-dependence of is shown to be a potential tool to extract the average intrinsic transverse momentum squared of partons, , as a function of x Bj and Q 2 in a leading order QCD parton model.

  7. Nuclear dependence of structure functions in the shadowing region of deep inelastic scattering

    SciTech Connect

    Berger, E.L.; Qiu, Jianwei

    1988-07-27

    A discussion of nuclear shadowing in deep inelastic lepton scattering is presented. We show that the parton recombination model suggests that shadowing should begin to occur at larger values of Bjorken x as A increases. This expectation as well as that of weak dependence on Q/sup 2/, and the trend of the x dependence of the shadowing phenomenon are consistent with recent data. Shadowing at small x is combined with nuclear bound state effects, responsible for nuclear dependence at larger x, to provide description of the A dependence of the structure function for the entire range of x. 21 refs., 5 figs.

  8. Final-state interactions in semi-inclusive deep inelastic scattering off the Deuteron

    SciTech Connect

    Wim Cosyn, Misak Sargsian

    2011-07-01

    Semi-inclusive deep inelastic scattering off the Deuteron with production of a slow nucleon in recoil kinematics is studied in the virtual nucleon approximation, in which the final state interaction (FSI) is calculated within general eikonal approximation. The cross section is derived in a factorized approach, with a factor describing the virtual photon interaction with the off-shell nucleon and a distorted spectral function accounting for the final-state interactions. One of the main goals of the study is to understand how much the general features of the diffractive high energy soft rescattering accounts for the observed features of FSI in deep inelastic scattering (DIS). Comparison with the Jefferson Lab data shows good agreement in the covered range of kinematics. Most importantly, our calculation correctly reproduces the rise of the FSI in the forward direction of the slow nucleon production angle. By fitting our calculation to the data we extracted the W and Q{sup 2} dependences of the total cross section and slope factor of the interaction of DIS products, X, off the spectator nucleon. This analysis shows the XN scattering cross section rising with W and decreasing with an increase of Q{sup 2}. Finally, our analysis points at a largely suppressed off-shell part of the rescattering amplitude.

  9. Final-state interactions in semi-inclusive deep inelastic scattering off the deuteron

    NASA Astrophysics Data System (ADS)

    Cosyn, W.; Sargsian, M.

    2011-07-01

    Semi-inclusive deep inelastic scattering off the deuteron with production of a slow nucleon in recoil kinematics is studied in the virtual nucleon approximation, in which the final-state interaction (FSI) is calculated within generalized eikonal approximation. The cross section is derived in a factorized approach, with a factor describing the virtual photon interaction with the off-shell nucleon and a distorted spectral function accounting for the final-state interactions. One of the main goals of the study is to understand how much the general features of the diffractive high-energy soft rescattering accounts for the observed features of FSI in deep inelastic scattering (DIS). Comparison with the Jefferson Lab data shows good agreement in the covered range of kinematics. Most importantly, our calculation correctly reproduces the rise of the FSI in the forward direction of the slow nucleon production angle. By fitting our calculation to the data we extracted the W and Q2 dependencies of the total cross section and slope factor of the interaction of DIS products, X, off the spectator nucleon. This analysis shows the XN-scattering cross section rising with W and decreasing with an increase of Q2. Finally, our analysis points at a largely suppressed off-shell part of the rescattering amplitude.

  10. Single-spin asymmetries in semi-inclusive deep inelastic scattering and Drell-Yan processes

    SciTech Connect

    Brodsky, Stanley J.; Hwang, Dae Sung; Kovchegov, Yuri V.; Schmidt, Ivan; Sievert, Matthew D.

    2013-07-01

    We examine in detail the diagrammatic mechanisms which provide the change of sign between the single transverse spin asymmetries measured in semi-inclusive deep inelastic scattering (SIDIS) and in the Drell-Yan process (DY). This asymmetry is known to arise due to the transverse spin dependence of the target proton combined with a T-odd complex phase. Using the discrete symmetry properties of transverse spinors, we show that the required complex phase originates in the denominators of rescattering diagrams and their respective cuts. For simplicity, we work in a model where the proton consists of a valence quark and a scalar diquark. We then show that the phases generated in SIDIS and in DY originate from distinctly different cuts in the amplitudes, which at first appears to obscure the relationship between the single-spin asymmetries in the two processes. Nevertheless, further analysis demonstrates that the contributions of these cuts are identical in the leading-twist Bjorken kinematics considered, resulting in the standard sign-flip relation between the Sivers functions in SIDIS and DY. Physically, this fundamental, but yet untested, prediction occurs because the Sivers effect in the Drell-Yan reaction is modified by the initial-state “lensing” interactions of the annihilating antiquark, in contrast to the final-state lensing which produces the Sivers effect in deep inelastic scattering.

  11. Polarized Electron - Polarized Deuteron Deep-Inelastic Scattering in Electron-Ion Collider with Tagging

    NASA Astrophysics Data System (ADS)

    Sargsian, Misak; Cosyn, Wim; Weiss, Christian

    2015-10-01

    For the past several years there have been an intensive research and development for the possible electron-ion collider that will be able to probe deep inelastic processes at unprecedentedly high energies in eA channel. One of the important advantages of the collider kinematics in DIS processes is the possibility for an unambiguous separation of hadrons emerging from DIS and hadrons fragmenting from the target nucleus. This creates a unique possibility for tagging the interacting nucleon with the recoil slow fragments in the DIS process. The situation is most clean for the deuteron target in which case the recoil particle is a nucleon. In addition, the possibility of having polarized deuteron beams will create unprecedented opportunities in probing polarization degrees of freedom for parton distributions in the interacting bound nucleon. In this work we develop a theoretical framework for the polarized electron-polarized deuteron deep inelastic scattering in which the recoil nucleon is detected in the target fragmentation region. Two main contributions for which theoretical models are developed are the plane-wave impulse approximation, in which no reinteractions are taking place between the final state products of DIS and the recoil nucleon.

  12. First Search for the EMC Effect and Nuclear Shadowing in Neutrino Nucleus Deep Inelastic Scattering at MINERvA

    SciTech Connect

    Mousseau, Joel A.

    2015-01-01

    Decades of research in electron-nucleus deep inelastic scattering (DIS) have provided a clear picture of nuclear physics at high momentum transfer. While these effects have been clearly demonstrated by experiment, the theoretical explanation of their origin in some kinematic regions has been lacking. Particularly, the effects in the intermediate regions of Bjorken-x, anti-shadowing and the EMC effect have no universally accepted quantum mechanical explanation. In addition, these effects have not been measured systematically with neutrino-nucleus deep inelastic scattering, due to experiments lacking multiple heavy targets.

  13. D^* production in deep-inelastic scattering at low Q^2

    SciTech Connect

    Jung, Andreas W.; /Fermilab

    2011-07-01

    Inclusive production of D* mesons in deep-inelastic scattering at HERA is studied in the range 5 < Q{sup 2} < 100 GeV{sup 2} of the photon virtuality and 0.02 < y < 0.70 of the inelasticity of the scattering process. The visible range for the D* meson is p{sub T} (D*) > 1.25 GeV and |{eta}(D*)| < 1.8. The data were taken with the H1 detector in the years 2004 to 2007 and correspond to an integrated luminosity of 347 pb{sup -1}. Single and double differential cross sections are measured. The results are compared to QCD predictions.

  14. Single and Double Spin Asymmetries for Semi-Inclusive Deep Inelastic Scattering on Proton and Deuteron

    NASA Astrophysics Data System (ADS)

    Koirala, Suman; Kuhn, Sebastian

    2013-04-01

    Transverse momentum dependent (TMD) parton distribution functions encode information on the transverse motion of quarks and gluons inside the nucleon, and may help us understand their orbital angular momentum. The TMDs can be accessed from the target and double spin asymmetries of semi-inclusive deep inelastic scattering (SIDIS) reactions, where the asymmetries, AUL and ALL are convolutions of the fragmentation functions and the TMDs. The EG1-DVCS experiment with CLAS at Jefferson Lab measured semi-inclusive pion production on longitudinally polarized proton and deuteron targets with polarized electrons of 6 GeV. We will show preliminary results on target single spin asymmetries and target-beam double spin asymmetries for these reactions.

  15. The exclusive production of Rho mesons in deep inelastic scattering at HERA

    NASA Astrophysics Data System (ADS)

    Bulmahn, Jeffrey W.

    1997-11-01

    The exclusive production of ρ0 mesons in deep inelastic scattering (DIS) was studied using data obtained with the ZEUS detector from the 1994 HERA run. The cross section for this process has been determined in the range 3 < Q2 < 30 [ GeV2] and 42 < W < 141 [ GeV], subject to the restrictions pT2 < 0.6 [ GeV2] and 0.4 < M/piπ/

  16. Towards semi-inclusive deep inelastic scattering at next-to-next-to-leading order

    NASA Astrophysics Data System (ADS)

    Anderle, Daniele; de Florian, Daniel; Rotstein Habarnau, Yamila

    2017-02-01

    In this paper, we compute the first set of O (αs2) corrections to semi-inclusive deep inelastic scattering structure functions. We start by studying the impact of the contribution of the partonic subprocesses that open at this order for the longitudinal structure function. We perform the full calculation analytically, and obtain the expression of the factorized cross section at this order. Special care is given to the study of their flavor decomposition structure. We analyze the phenomenological effect of the corrections finding that, even though expected to be small a priori, it turns out to be sizable with respect to the previous order known, calling for a full next-to-next-to-leading order calculation.

  17. Jet production in deep-inelastic muon scattering at 490 GeV

    SciTech Connect

    Melanson, H.L.; E665 Collaboration

    1993-06-01

    Measurements of jet rates in deep-inelastic muon scattering are presented. The JADE algorithm is used to define jets in the kinematic region 9 < W < 33 GeV. Data taken on a proton target are analyzed within the QCD framework, with the goal of extracting {alpha}{sub s}. Results on the Q{sup 2} dependence of the average transverse momentum of jets are used to demonstrate the running of the strong coupling constant {alpha}{sub s}. In addition, first measurements of the production of jets from heavy nuclei in the region x{sub B{sub j}} > 0.001 are discussed. Initial results indicate a suppression in the rate of two forward jets in carbon, calcium and lead as compared to deuterium. All results presented are preliminary.

  18. Multi-jet production rates in deep-inelastic muon-proton scattering

    SciTech Connect

    Salgado, C.W.

    1992-10-01

    Measurements of forward multi-jet production rates in deep-inelastic muonproton scattering are presented. Data were taken with a 490 GeV muon beam incident on a hydrogen target. Jets were defined using the JADE jet finding algorithm. The measured rates are presented as function of W, the hadronic center-of-mass energy and the jet resolution parameter, y[sub cut], in energies up to W=33 GeV. Good agreement is found in comparisons with predictions of the QCD-inspired Lund Monte Carlo models. Non-perturbative QCD production mechanisms, inside the Lund Model, can not reproduce the results for energies greater than W [approx equal] 20 GeV. Sensitivities of the jet rate measurements to the low x (x [approx equal] 0.02) gluon content of the nucleon and the evolution of [alpha][sub s], are studied.

  19. Multi-jet production rates in deep-inelastic muon-proton scattering

    SciTech Connect

    Salgado, C.W.; E665 Collaboration

    1992-10-01

    Measurements of forward multi-jet production rates in deep-inelastic muonproton scattering are presented. Data were taken with a 490 GeV muon beam incident on a hydrogen target. Jets were defined using the JADE jet finding algorithm. The measured rates are presented as function of W, the hadronic center-of-mass energy and the jet resolution parameter, y{sub cut}, in energies up to W=33 GeV. Good agreement is found in comparisons with predictions of the QCD-inspired Lund Monte Carlo models. Non-perturbative QCD production mechanisms, inside the Lund Model, can not reproduce the results for energies greater than W {approx_equal} 20 GeV. Sensitivities of the jet rate measurements to the low x (x {approx_equal} 0.02) gluon content of the nucleon and the evolution of {alpha}{sub s}, are studied.

  20. Measurement of azimuthal hadron asymmetries in semi-inclusive deep inelastic scattering off unpolarised nucleons

    NASA Astrophysics Data System (ADS)

    Adolph, C.; Akhunzyanov, R.; Alexeev, M. G.; Alexandrov, Yu.; Alexeev, G. D.; Amoroso, A.; Andrieux, V.; Anosov, V.; Austregesilo, A.; Badełek, B.; Balestra, F.; Barth, J.; Baum, G.; Beck, R.; Bedfer, Y.; Berlin, A.; Bernhard, J.; Bertini, R.; Bicker, K.; Bieling, J.; Birsa, R.; Bisplinghoff, J.; Bodlak, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bravar, A.; Bressan, A.; Büchele, M.; Burtin, E.; Capozza, L.; Chiosso, M.; Chung, S. U.; Cicuttin, A.; Crespo, M. L.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S. S.; Dasgupta, S.; Denisov, O. Yu.; Donskov, S. V.; Doshita, N.; Duic, V.; Dünnweber, W.; Dziewiecki, M.; Efremov, A.; Elia, C.; Eversheim, P. D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Filin, A.; Finger, M.; Finger, M.; Fischer, H.; Franco, C.; du Fresne von Hohenesche, N.; Friedrich, J. M.; Frolov, V.; Garfagnini, R.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Geyer, R.; Giorgi, M.; Gnesi, I.; Gobbo, B.; Goertz, S.; Gorzellik, M.; Grabmüller, S.; Grasso, A.; Grube, B.; Guskov, A.; Guthörl, T.; Haas, F.; von Harrach, D.; Hahne, D.; Hashimoto, R.; Heinsius, F. H.; Herrmann, F.; Hinterberger, F.; Höppner, Ch.; Horikawa, N.; d'Hose, N.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jary, V.; Jasinski, P.; Joerg, P.; Joosten, R.; Kabuß, E.; Kang, D.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Yu. A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Königsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O.; Kral, Z.; Krämer, M.; Kroumchtein, Z. V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levorato, S.; Lichtenstadt, J.; Maggiora, A.; Magnon, A.; Makke, N.; Mallot, G. K.; Marchand, C.; Martin, A.; Marzec, J.; Matousek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Miyachi, Y.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neubert, S.; Neyret, D.; Nikolaenko, V. I.; Novy, J.; Nowak, W.-D.; Nunes, A. S.; Orlov, I.; Olshevsky, A. G.; Ostrick, M.; Panknin, R.; Panzieri, D.; Parsamyan, B.; Paul, S.; Pesek, M.; Peshekhonov, D.; Piragino, G.; Platchkov, S.; Pochodzalla, J.; Polak, J.; Polyakov, V. A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Reicherz, G.; Rocco, E.; Rodionov, V.; Rondio, E.; Rychter, A.; Rossiyskaya, N. S.; Ryabchikov, D. I.; Samoylenko, V. D.; Sandacz, A.; Sarkar, S.; Savin, I. A.; Sbrizzai, G.; Schiavon, P.; Schill, C.; Schlüter, T.; Schmidt, A.; Schmidt, K.; Schmieden, H.; Schönning, K.; Schopferer, S.; Schott, M.; Shevchenko, O. Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Sosio, S.; Sozzi, F.; Srnka, A.; Steiger, L.; Stolarski, M.; Sulc, M.; Sulej, R.; Suzuki, H.; Szableski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; ter Wolbeek, J.; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Uhl, S.; Uman, I.; Vandenbroucke, M.; Virius, M.; Vondra, J.; Wang, L.; Weisrock, T.; Wilfert, M.; Windmolders, R.; Wiślicki, W.; Wollny, H.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.

    2014-09-01

    Spin-averaged asymmetries in the azimuthal distributions of positive and negative hadrons produced in deep inelastic scattering were measured using the CERN SPS longitudinally polarised muon beam at 160 GeV/c and a 6LiD target. The amplitudes of the three azimuthal modulations cos⁡ϕh, cos⁡2ϕh and sin⁡ϕh were obtained binning the data separately in each of the relevant kinematic variables x, z or pTh and binning in a three-dimensional grid of these three variables. The amplitudes of the cos⁡ϕh and cos⁡2ϕh modulations show strong kinematic dependencies both for positive and negative hadrons.

  1. Agreement of neutrino deep inelastic scattering data with global fits of parton distributions.

    PubMed

    Paukkunen, Hannu; Salgado, Carlos A

    2013-05-24

    The compatibility of neutrino-nucleus deep inelastic scattering data within the universal, factorizable nuclear parton distribution functions has been studied independently by several groups in the past few years. The conclusions are contradictory, ranging from a violation of the universality up to a good agreement, most of the controversy originating from the use of the neutrino-nucleus data from the NuTeV Collaboration. Here, we pay attention to non-negligible differences in the absolute normalization between different neutrino data sets. We find that such variations are large enough to prevent a tensionless fit to all data simultaneously and could therefore misleadingly point towards nonuniversal nuclear effects. We propose a concrete method to deal with the absolute normalization and show that an agreement between independent neutrino data sets is established.

  2. Production of exclusive dijets in diffractive deep inelastic scattering at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Antonelli, S.; Aushev, V.; Aushev, Y.; Behnke, O.; Behrens, U.; Bertolin, A.; Bloch, I.; Boos, E. G.; Borras, K.; Brock, I.; Brook, N. H.; Brugnera, R.; Bruni, A.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; Dementiev, R. K.; Devenish, R. C. E.; Dolinska, G.; Dusini, S.; Figiel, J.; Foster, B.; Gach, G.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Jomhari, N. Z.; Kadenko, I.; Kananov, S.; Karshon, U.; Kaur, M.; Kaur, P.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kotański, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Krupa, B.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Makarenko, I.; Malka, J.; Mergelmeyer, S.; Mohamad Idris, F.; Mohammad Nasir, N.; Myronenko, V.; Nagano, K.; Nobe, T.; Notz, D.; Nowak, R. J.; Onishchuk, Yu.; Paul, E.; Perlański, W.; Pokrovskiy, N. S.; Przybycień, M.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schneekloth, U.; Schörner-Sadenius, T.; Shcheglova, L. M.; Shevchenko, R.; Shkola, O.; Shyrma, Yu.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Solano, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zhmak, N.; Zotkin, D. S.

    2016-01-01

    Production of exclusive dijets in diffractive deep inelastic e^± p scattering has been measured with the ZEUS detector at HERA using an integrated luminosity of 372 pb^{-1}. The measurement was performed for γ ^{*}- p centre-of-mass energies in the range 90< W < {250} {GeV} and for photon virtualities Q^2 > {25} {GeV2}. Energy flows around the jet axis are presented. The cross section is presented as a function of β and φ , where β =x/x_IP, x is the Bjorken variable and x_IP is the proton fractional longitudinal momentum loss. The angle φ is defined by the γ ^{*}-dijet plane and the γ ^{*}-e^± plane in the rest frame of the diffractive final state. The φ cross section is measured in bins of β . The results are compared to predictions from models based on different assumptions about the nature of the diffractive exchange.

  3. Nucleon-nucleon correlations and multiquark cluster effects in semi-inclusive deep inelastic lepton scattering off

    SciTech Connect

    Simula, S.

    1994-04-01

    Semi-inclusive deep inelastic lepton scattering off nuclei is investigated assuming that virtual boson absorption occurs on a hadronic cluster which can be either a two-nucleon correlated pair or a six-quark bag. The differences in the energy distribution of nucleons produced in backward and forward directions are analyzed both at x<1 and x>1.

  4. Jet rates from deep inelastic muon scattering in the W range of 15 to 35 GeV

    SciTech Connect

    Salgado, C.

    1991-08-01

    Production rates of forward jets in deep inelastic muon scattering are studied using the JADE jet finding algorithm. The evolution of di-jet rates with W is compared to QCD first order predictions in the W range of 15 to 25 GeV. 7 refs., 3 figs.

  5. Measurement of partonic nuclear effects in deep-inelastic neutrino scattering using MINERvA

    DOE PAGES

    Mousseau, J.

    2016-04-19

    Here, the MINERvA Collaboration reports a novel study of neutrino-nucleus charged-current deep inelastic scattering (DIS) using the same neutrino beam incident on targets of polystyrene, graphite, iron, and lead. Results are presented as ratios of C, Fe, and Pb to CH. The ratios of total DIS cross sections as a function of neutrino energy and flux-integrated differential cross sections as a function of the Bjorken scaling variable x are presented in the neutrino-energy range of 5–50 GeV. Based on the predictions of charged-lepton scattering ratios, good agreement is found between the data and prediction at medium x and low neutrino energy.more » However, the ratios appear to be below predictions in the vicinity of the nuclear shadowing region, x < 0.1. This apparent deficit, reflected in the DIS cross-section ratio at high Eν, is consistent with previous MINERvA observations [B. Tice (MINERvA Collaboration), Phys. Rev. Lett. 112, 231801 (2014).] and with the predicted onset of nuclear shadowing with the axial-vector current in neutrino scattering.« less

  6. Measurement of partonic nuclear effects in deep-inelastic neutrino scattering using MINERvA

    SciTech Connect

    Mousseau, J.

    2016-04-19

    Here, the MINERvA Collaboration reports a novel study of neutrino-nucleus charged-current deep inelastic scattering (DIS) using the same neutrino beam incident on targets of polystyrene, graphite, iron, and lead. Results are presented as ratios of C, Fe, and Pb to CH. The ratios of total DIS cross sections as a function of neutrino energy and flux-integrated differential cross sections as a function of the Bjorken scaling variable x are presented in the neutrino-energy range of 5–50 GeV. Based on the predictions of charged-lepton scattering ratios, good agreement is found between the data and prediction at medium x and low neutrino energy. However, the ratios appear to be below predictions in the vicinity of the nuclear shadowing region, x < 0.1. This apparent deficit, reflected in the DIS cross-section ratio at high Eν, is consistent with previous MINERvA observations [B. Tice (MINERvA Collaboration), Phys. Rev. Lett. 112, 231801 (2014).] and with the predicted onset of nuclear shadowing with the axial-vector current in neutrino scattering.

  7. Measurement of partonic nuclear effects in deep-inelastic neutrino scattering using MINERvA

    NASA Astrophysics Data System (ADS)

    Mousseau, J.; Wospakrik, M.; Aliaga, L.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Budd, H.; Cai, T.; Carneiro, M. F.; Christy, M. E.; Chvojka, J.; da Motta, H.; Devan, J.; Dytman, S. A.; Díaz, G. A.; Eberly, B.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Gallagher, H.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Hurtado, K.; Kiveni, M.; Kleykamp, J.; Kordosky, M.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Marshall, C. M.; Martinez Caicedo, D. A.; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman; Osta, J.; Paolone, V.; Park, J.; Patrick, C. E.; Perdue, G. N.; Rakotondravohitra, L.; Ramirez, M. A.; Ransome, R. D.; Ray, H.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schellman, H.; Schmitz, D. W.; Solano Salinas, C. J.; Tagg, N.; Tice, B. G.; Valencia, E.; Walton, T.; Wolcott, J.; Zavala, G.; Zhang, D.; Minerν A Collaboration

    2016-04-01

    The MINERvA Collaboration reports a novel study of neutrino-nucleus charged-current deep inelastic scattering (DIS) using the same neutrino beam incident on targets of polystyrene, graphite, iron, and lead. Results are presented as ratios of C, Fe, and Pb to CH. The ratios of total DIS cross sections as a function of neutrino energy and flux-integrated differential cross sections as a function of the Bjorken scaling variable x are presented in the neutrino-energy range of 5-50 GeV. Based on the predictions of charged-lepton scattering ratios, good agreement is found between the data and prediction at medium x and low neutrino energy. However, the ratios appear to be below predictions in the vicinity of the nuclear shadowing region, x <0.1 . This apparent deficit, reflected in the DIS cross-section ratio at high Eν, is consistent with previous MINERvA observations [B. Tice et al. (MINERvA Collaboration), Phys. Rev. Lett. 112, 231801 (2014).] and with the predicted onset of nuclear shadowing with the axial-vector current in neutrino scattering.

  8. Multiplicities of charged kaons from deep-inelastic muon scattering off an isoscalar target

    NASA Astrophysics Data System (ADS)

    Adolph, C.; Aghasyan, M.; Akhunzyanov, R.; Alexeev, M. G.; Alexeev, G. D.; Amoroso, A.; Andrieux, V.; Anfimov, N. V.; Anosov, V.; Augsten, K.; Augustyniak, W.; Austregesilo, A.; Azevedo, C. D. R.; Badełek, B.; Balestra, F.; Ball, M.; Barth, J.; Beck, R.; Bedfer, Y.; Bernhard, J.; Bicker, K.; Bielert, E. R.; Birsa, R.; Bodlak, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bressan, A.; Büchele, M.; Capozza, L.; Chang, W.-C.; Chatterjee, C.; Chiosso, M.; Choi, I.; Chung, S.-U.; Cicuttin, A.; Crespo, M. L.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S. S.; Dasgupta, S.; Denisov, O. Yu.; Dhara, L.; Donskov, S. V.; Doshita, N.; Dreisbach, Ch.; Duic, V.; Dünnweber, W.; Dziewiecki, M.; Efremov, A.; Eversheim, P. D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Finger, M.; Finger, M.; Fischer, H.; Franco, C.; du Fresne von Hohenesche, N.; Friedrich, J. M.; Frolov, V.; Fuchey, E.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Giordano, F.; Gnesi, I.; Gorzellik, M.; Grabmüller, S.; Grasso, A.; Grosse Perdekamp, M.; Grube, B.; Grussenmeyer, T.; Guskov, A.; Haas, F.; Hahne, D.; Hamar, G.; von Harrach, D.; Heinsius, F. H.; Heitz, R.; Herrmann, F.; Horikawa, N.; d'Hose, N.; Hsieh, C.-Y.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jary, V.; Joosten, R.; Jörg, P.; Kabuß, E.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Yu. A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Königsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O. M.; Krämer, M.; Kremser, P.; Krinner, F.; Kroumchtein, Z. V.; Kulinich, Y.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levillain, M.; Levorato, S.; Lian, Y.-S.; Lichtenstadt, J.; Longo, R.; Maggiora, A.; Magnon, A.; Makins, N.; Makke, N.; Mallot, G. K.; Marianski, B.; Martin, A.; Marzec, J.; Matoušek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G. V.; Meyer, M.; Meyer, W.; Mikhailov, Yu. V.; Mikhasenko, M.; Mitrofanov, E.; Mitrofanov, N.; Miyachi, Y.; Nagaytsev, A.; Nerling, F.; Neyret, D.; Nový, J.; Nowak, W.-D.; Nukazuka, G.; Nunes, A. S.; Olshevsky, A. G.; Orlov, I.; Ostrick, M.; Panzieri, D.; Parsamyan, B.; Paul, S.; Peng, J.-C.; Pereira, F.; Pešek, M.; Peshekhonov, D. V.; Pierre, N.; Platchkov, S.; Pochodzalla, J.; Polyakov, V. A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Regali, C.; Reicherz, G.; Riedl, C.; Roskot, M.; Rossiyskaya, N. S.; Ryabchikov, D. I.; Rybnikov, A.; Rychter, A.; Salac, R.; Samoylenko, V. D.; Sandacz, A.; Santos, C.; Sarkar, S.; Savin, I. A.; Sawada, T.; Sbrizzai, G.; Schiavon, P.; Schmidt, K.; Schmieden, H.; Schönning, K.; Seder, E.; Selyunin, A.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Smolik, J.; Sozzi, F.; Srnka, A.; Steffen, D.; Stolarski, M.; Subrt, O.; Sulc, M.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; Tasevsky, M.; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Thiel, A.; Tosello, F.; Tskhay, V.; Uhl, S.; Veloso, J.; Virius, M.; Vondra, J.; Wallner, S.; Weisrock, T.; Wilfert, M.; Windmolders, R.; ter Wolbeek, J.; Zaremba, K.; Zavada, P.; Zavertyaev, M.; Zemlyanichkina, E.; Zhuravlev, N.; Ziembicki, M.; Zink, A.

    2017-04-01

    Precise measurements of charged-kaon multiplicities in deep inelastic scattering were performed. The results are presented in three-dimensional bins of the Bjorken scaling variable x, the relative virtual-photon energy y, and the fraction z of the virtual-photon energy carried by the produced hadron. The data were obtained by the COMPASS Collaboration by scattering 160 GeV muons off an isoscalar 6LiD target. They cover the kinematic domain 1(GeV / c) 2 5 GeV /c2 in the invariant mass of the hadronic system. The results from the sum of the z-integrated K+ and K- multiplicities at high x point to a value of the non-strange quark fragmentation function larger than obtained by the earlier DSS fit.

  9. Ordered analysis of heavy flavor production in deep-inelastic scattering

    NASA Astrophysics Data System (ADS)

    Thorne, R. S.; Roberts, R. G.

    1998-06-01

    At low Q2, charm production in deep-inelastic scattering is adequately described by assuming generation in electroweak boson-light parton scattering (dominantly boson-gluon fusion), which naturally incorporates the correct threshold behavior. At high Q2 this description is inadequate, since it does not sum logs in Q2/m2c, and is replaced by the treatment of the charm quark as a light parton. We show how the problem of going from one description to the other can be solved in a satisfactory manner to all orders. The key ingredient is the constraint of matching the evolution of the physical structure function F2 order by order in αs(Q2), in addition, to the matching of the value of F2 itself. This leads to new expressions for the coefficient functions associated with the charm parton, which are unique in incorporating both the correct threshold and asymptotic behaviors at each order in perturbation theory. The use of these improved coefficients leads to an improvement in global fits and an excellent description of the observed F2,charm.

  10. Final-state interactions in inclusive deep-inelastic scattering from the deuteron

    DOE PAGES

    Cosyn, Wim; Melnitchouk, Wally; Sargsian, Misak M.

    2014-01-16

    We explore the role of final-state interactions (FSI) in inclusive deep-inelastic scattering from the deuteron. Relating the inclusive cross section to the deuteron forward virtual Compton scattering amplitude, a general formula for the FSI contribution is derived in the generalized eikonal approximation, utilizing the diffractive nature of the effective hadron-nucleon interaction. The calculation uses a factorized model with a basis of three resonances with mass W~<2 GeV and a continuum contribution for larger W as the relevant set of effective hadron states entering the final-state interaction amplitude. The results show sizeable on-shell FSI contributions for Bjorken x ~> 0.6 andmore » Q2 < 10 GeV2 increasing in magnitude for lower Q2, but vanishing in the high-Q2 limit due to phase space constraints. The off-shell rescattering contributes at x ~> 0.8 and is taken as an uncertainty on the on-shell result.« less

  11. Diffractive deep inelastic scattering in an AdS/CFT inspired model: A phenomenological study

    SciTech Connect

    Betemps, M. A.; Goncalves, V. P.; Santana Amaral, J. T. de

    2010-05-01

    The analytical treatment of the nonperturbative QCD dynamics is one of the main open questions of the strong interactions. Currently, it is only possible to get some qualitative information about this regime considering other QCD-like theories, as, for example, the N=4 super Yang-Mills theory, where one can perform calculations in the nonperturbative limit of large 't Hooft coupling using the anti-de Sitter space/conformal field theory (AdS/CFT). Recently, the high energy scattering amplitude was calculated in the AdS/CFT approach, applied to deep-inelastic scattering and confronted with the F{sub 2} HERA data. In this work we extend the nonperturbative AdS/CFT inspired model for diffractive processes and compare its predictions with a perturbative approach based on the Balitsky-Kovchegov equation. We demonstrate that the AdS/CFT inspired model is not able to describe the current F{sub 2}{sup D(3)} HERA data and predicts a similar behavior to that from the Balitsky-Kovchegov equation in the range 10{sup -7} < or approx. x{sub P} < or approx. 10{sup -4}. At smaller values of x{sub P} the diffractive structure function is predicted to be energy independent.

  12. Search for a narrow baryonic state decaying to p KS0 and p ‾ KS0 in deep inelastic scattering at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Antonelli, S.; Aushev, V.; Behnke, O.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Boos, E. G.; Brock, I.; Brook, N. H.; Brugnera, R.; Bruni, A.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Dementiev, R. K.; Devenish, R. C. E.; Dusini, S.; Foster, B.; Gach, G.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Golubkov, Yu. A.; Grzelak, G.; Guzik, M.; Gwenlan, C.; Hain, W.; Hlushchenko, O.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Januschek, F.; Jomhari, N. Z.; Kadenko, I.; Kananov, S.; Karshon, U.; Kaur, P.; Kisielewska, D.; Klanner, R.; Klein, U.; Korzhavina, I. A.; Kotański, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Krupa, B.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Makarenko, I.; Malka, J.; Mastroberardino, A.; Mohamad Idris, F.; Mohammad Nasir, N.; Myronenko, V.; Nagano, K.; Nobe, T.; Nowak, R. J.; Onishchuk, Yu.; Paul, E.; Perlański, W.; Pokrovskiy, N. S.; Polini, A.; Przybycień, M.; Roloff, P.; Ruspa, M.; Saxon, D. H.; Schioppa, M.; Schneekloth, U.; Schörner-Sadenius, T.; Shcheglova, L. M.; Shevchenko, R.; Shkola, O.; Shyrma, Yu.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Solano, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stopa, P.; Sztuk-Dambietz, J.; Tassi, E.; Tokushuku, K.; Tomaszewska, J.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zotkin, D. S.

    2016-08-01

    A search for a narrow baryonic state in the p KS0 and p ‾ KS0 system has been performed in ep collisions at HERA with the ZEUS detector using an integrated luminosity of 358pb-1 taken in 2003-2007. The search was performed with deep inelastic scattering events at an ep centre-of-mass energy of 318GeV for exchanged photon virtuality, Q2, between 20 and 100GeV2. Contrary to evidence presented for such a state around 1.52 GeV in a previous ZEUS analysis using a sample of 121 pb-1 taken in 1996-2000, no resonance peak was found in the p (p ‾) KS0 invariant-mass distribution in the range 1.45-1.7 GeV. Upper limits on the production cross section are set.

  13. Parity Violating Deep Inelastic Electron Scattering from the Deuteron at 6 GeV

    SciTech Connect

    Pan, Kai

    2013-02-01

    An experiment that measured the parity violating (PV) asymmetry Ad in e-2H deep inelastic scattering (DIS) at Q2 ~ 1.10 and 1.90 (GeV/c)2 and xB ~ 0.3 was completed in experimental Hall A at the Thomas Jefferson National Accelerator Facility. The asymmetry can be used to extract the neutral weak coupling combination (2C2u-C2d), providing a factor of five to six improvement over the current world data. To achieve this precision, asymmetries of the 10-4 level needed to be measured at event rates up to 500 kHz with high electron detection efficiency and high pion background rejection capability. A specialized scaler-based counting data acquisition system (DAQ) with hardware-based particle identification was successfully implemented. The statistical quality of the asymmetry measurement agreed with the Gaussian distribution to over five orders of magnitudes and the experimental goal of 3-4% statistical uncertainty was achieved. The design and performance of the new DAQ system is presented with the preliminary asymmetry results given in the end.

  14. Simulator for the Parity-Violating Deep Inelastic Scattering experiment in the Solenoidal Large Intensity Detector

    NASA Astrophysics Data System (ADS)

    Anderson, Jack; Hall A SoLID Collaboration

    2013-10-01

    The Solenoid Large Intensity Detector (SoLID) particle detector is the main detector that will be used for high energy particle experiments in Hall A that will be used with the 12 GeV electron beam at the Jefferson Lab. SoLID geometries were writen to be implemented in Geant4 using openGL as the visualization tool. This will allow us to test how the calorimeter, a specific yet integral part of the SoLID detector, detects the particles that result from electron beams colliding with targets. The goal is to simulate the approved experiments for the SoLID detector, starting with the Parity-Violating Deep Inelastic Scattering (PVDIS) experiment. This will provide critical information regarding the effectiveness of the calorimeter's design for such experiments. The expectation is that a Shashlik calorimeter will prove effective for the experiments approved for the SoLID detector. The ideal number of layers, or types of material for said layers, is an aspect of the calorimeter that will require testing through the simulations.The geometry files allow an easily-packaged program that can be shared amongst any collaborators interested in the SoLID experiments. NSF Grant No. 714001.

  15. Longitudinal-Transverse Separation of Deep-Inelastic Scattering at Low Q² on Nucleons and Nuclei

    SciTech Connect

    Tvaskis, Vladas

    2004-12-06

    Since the early experiments at SLAC, which discovered the nucleon substructure and led to the development of the quark parton model, deep inelastic scattering (DIS) has been the most powerful tool to investigate the partonic substructure of the nucleon. After about 30 years of experiments with electron and muon beams the nucleon structure function F2(x,Q2) is known with high precision over about four orders of magnitude in x and Q2. In the region of Q2 > 1 (GeV/c)2 the results of the DIS measurements are interpreted in terms of partons (quarks and gluons). The theoretical framework is provided in this case by perturbative Quantum Chromo Dynamics (pQCD), which includes scaling violations, as described by the Dokshitzer-Gribov-Lipatov-Altarelli-Parisi (DGLAP) equations. The description starts to fail when Q2 becomes of the order of 1 (GeV/c)2, where non-perturbative effects (higher-twist effects), which are still not fully understood, become important (non-pQCD). The sensitivity for order-n twist effects increases with decreasing Q2, since they include a factor 1/(Q2n) (n ≥ 1).

  16. Electroweak higher-order effects and theoretical uncertainties in deep-inelastic neutrino scattering

    SciTech Connect

    Diener, K.-P.O.; Dittmaier, S.; Hollik, W.

    2005-11-01

    A previous calculation of electroweak O({alpha}) corrections to deep-inelastic neutrino scattering, as e.g. measured by NuTeV and NOMAD, is supplemented by higher-order effects. In detail, we take into account universal two-loop effects from {delta}{alpha} and {delta}{rho} as well as higher-order final-state photon radiation off muons in the structure function approach. Moreover, we make use of the recently released O({alpha})-improved parton distributions MRST2004QED and identify the relevant QED factorization scheme, which is DIS-like. As a technical by-product, we describe slicing and subtraction techniques for an efficient calculation of a new type of real corrections that are induced by the generated photon distribution. A numerical discussion of the higher-order effects suggests that the remaining theoretical uncertainty from unknown electroweak corrections is dominated by nonuniversal two-loop effects and is of the order 0.0003 when translated into a shift in sin{sup 2}{theta}{sub W}=1-M{sub W}{sup 2}/M{sub Z}{sup 2}. The O({alpha}) corrections implicitly included in the parton distributions lead to a shift of about 0.0004.

  17. Momentum space saturation model for deep inelastic scattering and single inclusive hadron production

    NASA Astrophysics Data System (ADS)

    Basso, E. A. F.; Gay Ducati, M. B.; de Oliveira, E. G.

    2011-08-01

    We show how the Santana Amaral-Gay Ducati-Betemps-Soyez (AGBS) model, originally developed for deep inelastic scattering applied to HERA data on the proton structure function, can also describe the RHIC data on single inclusive hadron yield for d+Au and p+p collisions through a new simultaneous fit. The single inclusive hadron production is modeled through the color glass condensate, which uses the quark (and gluon) condensate amplitudes in momentum space. The AGBS model is also a momentum space model based on the asymptotic solutions of the Balitsky-Kovchegov equation, although a different definition of the Fourier transform is used. This aspect is overcome, and a description entirely in transverse momentum of both processes arises for the first time. The small difference between the simultaneous fit and the one for HERA data alone suggests that the AGBS model describes very well both kinds of processes and thus emerges as a good tool to investigate the inclusive hadron production data. We use this model for predictions at LHC energies, which agrees very well with available experimental data.

  18. Final-State Interactions and Single-Spin Asymmetries in Semi-inclusive Deep Inelastic Scattering

    SciTech Connect

    Brodsky, Stanley J.; Hwang, Dae Sung; Schmidt, Ivan; /Santa Maria U., Valparaiso

    2007-11-14

    Recent measurements from the HERMES and SMC collaborations show a remarkably large azimuthal single-spin asymmetries A{sub UL} and A{sub UT} of the proton in semi-inclusive pion leptoproduction {gamma}*(q)p {yields} {pi}X. We show that final-state interactions from gluon exchange between the outgoing quark and the target spectator system leads to single-spin asymmetries in deep inelastic lepton-proton scattering at leading twist in perturbative QCD; i.e., the rescattering corrections are not power-law suppressed at large photon virtuality q{sup 2} at fixed x{sub bj}. The existence of such single-spin asymmetries requires a phase difference between two amplitudes coupling the proton target with J{sup z}{sub p} = {+-}1/2 to the same final-state, the same amplitudes which are necessary to produce a nonzero proton anomalous magnetic moment. We show that the exchange of gauge particles between the outgoing quark and the proton spectators produces a Coulomb-like complex phase which depends on the angular momentum L{sup z} of the proton's constituents and thus is distinct for different proton spin amplitudes. The single-spin asymmetry which arises from such final-state interactions does not factorize into a product of structure function and fragmentation function, and it is not related to the transversity distribution {delta}q(x;Q) which correlates transversely polarized quarks with the spin of the transversely polarized target nucleon.

  19. Triple gluon coupling, Adler-Bell-Jackiw anomaly, and polarized deep inelastic scattering

    SciTech Connect

    Lam, C.S.; Li, B.A.

    1980-05-01

    An unusual effect of triple gluon coupling and the Adler-Bell-Jackiw anomaly on the flavor singlet part of the polaried deep inelastic scattering structure function ..nu..G/sub 1/(Q/sup 2/,x) are discussed. Namely, the x-integral I/sub S/(Q/sup 2/) of this function is Q/sup 2/-independent both in parton model and leading logarithm calculations, but the first order nonleading logarithm calculation produces a term growing like (-lnlnQ/sup 2/), dominating over the parton model contributions at large Q/sup 2/. The detection of this unusual term will amount to an experimental confirmation of the existence of triple gluon coupling and the Adler-Bell-Jackiw anomaly. Technically, this term comes from a new axial vector gluon operator which is introduced in the Wilson expansion. Other results of this paper include a discussion of mass-sensitive and mass-insensitive structure functions and the derivation of the expression for, and the relations between, some of these structure functions.

  20. Distribution of Linearly Polarized Gluons and Elliptic Azimuthal Anisotropy in Deep Inelastic Scattering Dijet Production at High Energy

    SciTech Connect

    Dumitru, Adrian; Lappi, Tuomas; Skokov, Vladimir

    2015-12-17

    In this study, we determine the distribution of linearly polarized gluons of a dense target at small x by solving the Balitsky–Jalilian-Marian–Iancu–McLerran–Weigert–Leonidov–Kovner rapidity evolution equations. From these solutions, we estimate the amplitude of cos2Φ azimuthal asymmetries in deep inelastic scattering dijet production at high energies. We find sizable long-range in rapidity azimuthal asymmetries with a magnitude in the range of v2=~10%.

  1. Distribution of Linearly Polarized Gluons and Elliptic Azimuthal Anisotropy in Deep Inelastic Scattering Dijet Production at High Energy

    DOE PAGES

    Dumitru, Adrian; Lappi, Tuomas; Skokov, Vladimir

    2015-12-17

    In this study, we determine the distribution of linearly polarized gluons of a dense target at small x by solving the Balitsky–Jalilian-Marian–Iancu–McLerran–Weigert–Leonidov–Kovner rapidity evolution equations. From these solutions, we estimate the amplitude of cos2Φ azimuthal asymmetries in deep inelastic scattering dijet production at high energies. We find sizable long-range in rapidity azimuthal asymmetries with a magnitude in the range of v2=~10%.

  2. CT14QED parton distribution functions from isolated photon production in deep inelastic scattering

    NASA Astrophysics Data System (ADS)

    Schmidt, Carl; Pumplin, Jon; Stump, Daniel; Yuan, C.-P.

    2016-06-01

    We describe the implementation of quantum electrodynamic (QED) evolution at leading order (LO) along with quantum chromodynamic (QCD) evolution at next-to-leading order (NLO) in the CTEQ-TEA global analysis package. The inelastic contribution to the photon parton distribution function (PDF) is described by a two-parameter ansatz, coming from radiation off the valence quarks, and based on the CT14 NLO PDFs. Setting the two parameters to be equal allows us to completely specify the inelastic photon PDF in terms of the inelastic momentum fraction carried by the photon, p0γ, at the initial scale Q0=1.295 GeV . We obtain constraints on the photon PDF by comparing with ZEUS data [S. Chekanov et al. (ZEUS Collaboration), Phys. Lett. B 687, 16 (2010)] on the production of isolated photons in deep inelastic scattering, e p →e γ +X . For this comparison we present a new perturbative calculation of the process that consistently combines the photon-initiated contribution with the quark-initiated contribution. Comparison with the data allows us to put a constraint at the 90% confidence level of p0γ≲0.14 % for the inelastic photon PDF at the initial scale of Q0=1.295 GeV in the one-parameter radiative ansatz. The resulting inelastic CT14QED PDFs will be made available to the public. In addition, we also provide CT14QEDinc PDFs, in which the inclusive photon PDF at the scale Q0 is defined by the sum of the inelastic photon PDF and the elastic photon distribution obtained from the equivalent photon approximation.

  3. Charm-Quark Production in Deep-Inelastic Neutrino Scattering at Next-to-Next-to-Leading Order in QCD.

    PubMed

    Berger, Edmond L; Gao, Jun; Li, Chong Sheng; Liu, Ze Long; Zhu, Hua Xing

    2016-05-27

    We present a fully differential next-to-next-to-leading order calculation of charm-quark production in charged-current deep-inelastic scattering, with full charm-quark mass dependence. The next-to-next-to-leading order corrections in perturbative quantum chromodynamics are found to be comparable in size to the next-to-leading order corrections in certain kinematic regions. We compare our predictions with data on dimuon production in (anti)neutrino scattering from a heavy nucleus. Our results can be used to improve the extraction of the parton distribution function of a strange quark in the nucleon.

  4. Energy dissipation in heavy systems: the transition from quasi-elastic to deep-inelastic scattering

    SciTech Connect

    Rehm, K.E.; van den Berg, A.; Kolata, J.J.; Kovar, D.G.; Kutschera, W.; Rosner, G.; Stephans, G.S.F.; Yntema, J.L.; Lee, L.L.

    1984-01-01

    The interaction of medium mass projectiles (A = 28 - 64) with /sup 208/Pb has been studied using a split-pole spectrograph which allows single mass and charge identification. The reaction process in all systems studied so far is dominated by quasi-elastic neutron transfer reactions, especially at incident energies in the vicinity of the Coulomb barrier. In addition to the quasi-elastic component deep inelastic contributions are present in all reaction channels. The good mass and charge separation allows to generate Wilczynski plots for individual channels; for the system /sup 48/Ti + /sup 208/Pb we observe that the transition between the quasi-elastic and deep-inelastic reactions occurs around Q = -(30 to 35) MeV.

  5. Contribution of twist-3 multigluon correlation functions to single spin asymmetry in semi-inclusive deep inelastic scattering

    SciTech Connect

    Beppu, Hiroo; Yoshida, Shinsuke; Koike, Yuji; Tanaka, Kazuhiro

    2010-09-01

    As a possible source of the single transverse-spin asymmetry, we study the contribution from purely gluonic correlation represented by the twist-3 ''three-gluon correlation'' functions in the transversely polarized nucleon. We first define a complete set of the relevant three-gluon correlation functions, and then derive its contribution to the twist-3 single-spin-dependent cross section for the D-meson production in semi-inclusive deep inelastic scattering, which is relevant to determine the three-gluon correlations. Our cross-section formula differs from the corresponding result in the literature, and the origin of the discrepancy is clarified.

  6. Measurement of the Parity-Violating Asymmetry in Deep Inelastic Scattering at JLab 6 GeV

    SciTech Connect

    Wang, Diancheng

    2013-12-01

    The parity-violating asymmetry in deep inelastic scattering (PVDIS) offers us a useful tool to study the weak neutral couplings and the hadronic structure of the nucleon, and provides high precision tests on the Standard Model. During the 6 GeV PVDIS experiment at the Thomas Jefferson National Accelerator Facility, the parity-violating asymmetries A{sub PV} of a polarized electron beam scattering off an unpolarized deuteron target in the deep inelastic scattering region were precisely measured at two Q2 values of 1.1 and 1.9 (GeV/c)2. The asymmetry at Q2=1.9 (GeV/c)2 can be used to extract the weak coupling combination 2C2u - C2d, assuming the higher twist effect is small. The extracted result from this measurement is in good agreement with the Standard Model prediction, and improves the precision by a factor of five over previous data. In addition, combining the asymmetries at both Q2 values provides us extra knowledge on the higher twist effects. The parity violation asymmetries in the resonance region were also measured during this experiment. These results are the first APV data in the resonance region beyond the Δ (1232). They provide evidence that the quark hadron duality works for APV at the (10-15)% level, and set constraints on nucleon resonance models that are commonly used for background calculations to other parity-violating electron scattering measurements.

  7. Distorted spin dependent spectral function of {sup 3}He and semi-inclusive deep inelastic scattering processes

    SciTech Connect

    Kaptari, Leonya P.; Del Dotto, Alessio; Pace, Emanuele; Salme, Giovanni; Scopetta, Sergio

    2014-03-01

    The spin dependent spectral function, relevant to describe polarized electron scattering off polarized {sup 3}He, is studied, within the Plane Wave Impulse Approximation and taking into account final state interaction effects (FSI). In particular, the case of semi-inclusive deep inelastic scattering (SiDIS) is considered, evaluating the FSI of the hadronizing quark with the nuclear remnants. It is shown that particular kinematical regions can be selected to minimize the latter effects, so that parton distributions in the neutron can be accessed. On the other side, in the regions where FSI dominates, the considered reactions can elucidate the mechanism of hadronization of quarks during the propagation in the nuclear medium. It is shown that the obtained spin dependent spectral function can be directly applied to investigate the SiDIS reaction e-vector + {sup 3}He-vector to h+X, where the hadron h originates from the current fragmentation. Experiments of this type are being performed at JLab to extract neutron transverse momentum dependent parton distributions. As a case study, a different SiDIS process, with detection of slow (A-1) systems in the final state, is considered in more details, in order to establish when nuclear structure effects and FSI can be distinguished from elementary reactions on quasi-free nucleons. It is argued that, by a proper choice of kinematics, the origin of nuclear effects in polarized DIS phenomena and the details of the interaction between the hadronizing quark and the nuclear medium can be investigated at a level which is not reachable in inclusive deep inelastic scattering.

  8. Multiplicities of charged pions and charged hadrons from deep-inelastic scattering of muons off an isoscalar target

    NASA Astrophysics Data System (ADS)

    Adolph, C.; Aghasyan, M.; Akhunzyanov, R.; Alexeev, G. D.; Alexeev, M. G.; Amoroso, A.; Andrieux, V.; Anfimov, N. V.; Anosov, V.; Augsten, K.; Augustyniak, W.; Austregesilo, A.; Azevedo, C. D. R.; Badełek, B.; Balestra, F.; Barth, J.; Beck, R.; Bedfer, Y.; Bernhard, J.; Bicker, K.; Bielert, E. R.; Birsa, R.; Bisplinghoff, J.; Bodlak, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bressan, A.; Büchele, M.; Capozza, L.; Chang, W.-C.; Chatterjee, C.; Chiosso, M.; Choi, I.; Chung, S.-U.; Cicuttin, A.; Crespo, M. L.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S. S.; Dasgupta, S.; Denisov, O. Yu.; Dhara, L.; Donskov, S. V.; Doshita, N.; Duic, V.; Dünnweber, W.; Dziewiecki, M.; Efremov, A.; Eversheim, P. D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Finger, M.; Finger, M.; Fischer, H.; Franco, C.; du Fresne von Hohenesche, N.; Friedrich, J. M.; Frolov, V.; Fuchey, E.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Giordano, F.; Gnesi, I.; Gorzellik, M.; Grabmüller, S.; Grasso, A.; Grosse Perdekamp, M.; Grube, B.; Grussenmeyer, T.; Guskov, A.; Haas, F.; Hahne, D.; von Harrach, D.; Hashimoto, R.; Heinsius, F. H.; Heitz, R.; Herrmann, F.; Hinterberger, F.; Horikawa, N.; d'Hose, N.; Hsieh, C.-Y.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jary, V.; Joosten, R.; Jörg, P.; Kabuß, E.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Yu. A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Königsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O. M.; Krämer, M.; Kremser, P.; Krinner, F.; Kroumchtein, Z. V.; Kuhn, R.; Kulinich, Y.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levillain, M.; Levorato, S.; Lian, Y.-S.; Lichtenstadt, J.; Longo, R.; Maggiora, A.; Magnon, A.; Makins, N.; Makke, N.; Mallot, G. K.; Marchand, C.; Marianski, B.; Martin, A.; Marzec, J.; Matoušek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G. V.; Meyer, M.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Mikhasenko, M.; Mitrofanov, E.; Mitrofanov, N.; Miyachi, Y.; Montuenga, P.; Nagaytsev, A.; Nerling, F.; Neyret, D.; Nikolaenko, V. I.; Nový, J.; Nowak, W.-D.; Nukazuka, G.; Nunes, A. S.; Olshevsky, A. G.; Orlov, I.; Ostrick, M.; Panzieri, D.; Parsamyan, B.; Paul, S.; Peng, J.-C.; Pereira, F.; Pešek, M.; Peshekhonov, D. V.; Pierre, N.; Platchkov, S.; Pochodzalla, J.; Polyakov, V. A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Regali, C.; Reicherz, G.; Riedl, C.; Roskot, M.; Rossiyskaya, N. S.; Ryabchikov, D. I.; Rybnikov, A.; Rychter, A.; Salac, R.; Samoylenko, V. D.; Sandacz, A.; Santos, C.; Sarkar, S.; Savin, I. A.; Sawada, T.; Sbrizzai, G.; Schiavon, P.; Schmidt, K.; Schmieden, H.; Schönning, K.; Schopferer, S.; Seder, E.; Selyunin, A.; Shevchenko, O. Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Smolik, J.; Sozzi, F.; Srnka, A.; Steffen, D.; Stolarski, M.; Sulc, M.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; Tasevsky, M.; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Tosello, F.; Tskhay, V.; Uhl, S.; Veloso, J.; Virius, M.; Vondra, J.; Weisrock, T.; Wilfert, M.; Windmolders, R.; ter Wolbeek, J.; Zaremba, K.; Zavada, P.; Zavertyaev, M.; Zemlyanichkina, E.; Zhuravlev, N.; Ziembicki, M.; Zink, A.

    2017-01-01

    Multiplicities of charged pions and charged hadrons produced in deep-inelastic scattering were measured in three-dimensional bins of the Bjorken scaling variable x, the relative virtual-photon energy y and the relative hadron energy z. Data were obtained by the COMPASS Collaboration using a 160GeV muon beam and an isoscalar target (6LiD). They cover the kinematic domain in the photon virtuality Q2 > 1(GeV / c) 2, 0.004 < x < 0.4, 0.2 < z < 0.85 and 0.1 < y < 0.7. In addition, a leading-order pQCD analysis was performed using the pion multiplicity results to extract quark fragmentation functions.

  9. First measurement of unpolarized semi-inclusive deep-inelastic scattering cross sections from a 3He target

    NASA Astrophysics Data System (ADS)

    Yan, X.; Allada, K.; Aniol, K.; Annand, J. R. M.; Averett, T.; Benmokhtar, F.; Bertozzi, W.; Bradshaw, P. C.; Bosted, P.; Camsonne, A.; Canan, M.; Cates, G. D.; Chen, C.; Chen, J.-P.; Chen, W.; Chirapatpimol, K.; Chudakov, E.; Cisbani, E.; Cornejo, J. C.; Cusanno, F.; Dalton, M. M.; Deconinck, W.; de Jager, C. W.; De Leo, R.; Deng, X.; Deur, A.; Ding, H.; Dolph, P. A. M.; Dutta, C.; Dutta, D.; El Fassi, L.; Frullani, S.; Gao, H.; Garibaldi, F.; Gaskell, D.; Gilad, S.; Gilman, R.; Glamazdin, O.; Golge, S.; Guo, L.; Hamilton, D.; Hansen, O.; Higinbotham, D. W.; Holmstrom, T.; Huang, J.; Huang, M.; Ibrahim, H. F.; Iodice, M.; Jiang, X.; Jin, G.; Jones, M. K.; Katich, J.; Kelleher, A.; Kim, W.; Kolarkar, A.; Korsch, W.; LeRose, J. J.; Li, X.; Li, Y.; Lindgren, R.; Liu, T.; Liyanage, N.; Long, E.; Lu, H.-J.; Margaziotis, D. J.; Markowitz, P.; Marrone, S.; McNulty, D.; Meziani, Z.-E.; Michaels, R.; Moffit, B.; Muñoz Camacho, C.; Nanda, S.; Narayan, A.; Nelyubin, V.; Norum, B.; Oh, Y.; Osipenko, M.; Parno, D.; Peng, J.-C.; Phillips, S. K.; Posik, M.; Puckett, A. J. R.; Qian, X.; Qiang, Y.; Rakhman, A.; Ransome, R.; Riordan, S.; Saha, A.; Sawatzky, B.; Schulte, E.; Shahinyan, A.; Shabestari, M. H.; Širca, S.; Stepanyan, S.; Subedi, R.; Sulkosky, V.; Tang, L.-G.; Tobias, W. A.; Urciuoli, G. M.; Vilardi, I.; Wang, K.; Wojtsekhowski, B.; Wang, Y.; Yan, X.; Yao, H.; Ye, Y.; Ye, Z.; Yuan, L.; Zhan, X.; Zhang, Y.; Zhang, Y.-W.; Zhao, B.; Zhao, Y. X.; Zheng, X.; Zhu, L.; Zhu, X.; Zong, X.; Jefferson Lab Hall A Collaboration

    2017-03-01

    The unpolarized semi-inclusive deep-inelastic scattering (SIDIS) differential cross sections in 3He(e ,e'π±)X have been measured for the first time in Jefferson Lab experiment E06-010 with a 5.9 GeV e- beam on a 3He gas target. The experiment focuses on the valence quark region, covering a kinematic range 0.12

  10. First search for the EMC effect and nuclear shadowing in neutrino nucleus deep inelastic scattering at MINERVA

    NASA Astrophysics Data System (ADS)

    Mousseau, Joel A.

    Decades of research in electron-nucleus deep inelastic scattering (DIS) have provided a clear picture of nuclear physics at high momentum transfer. While these effects have been clearly demonstrated by experiment, the theoretical explanation of their origin in some kinematic regions has been lacking. Particularly, the effects in the intermediate regions of Bjorken-x, anti-shadowing and the EMC effect have no universally accepted quantum mechanical explanation. In addition, these effects have not been measured systematically with neutrino-nucleus deep inelastic scattering, due to experiments lacking multiple heavy targets. The MINERνA (Main Injector Experiment ν-A) experiment, located in the Neutrinos at the Main Injector (NuMI) facility at Fermilab, is designed explicitly to measure these kind of effects with neutrinos. MINEνA is equipped with solid targets of graphite, iron, lead and plastic scintillator. The plastic scintillator region provides excellent particle tracking capabilities, and the MINOS (Main Injector Neutrino Oscillation Search) near detector is used as a downstream muon spectrometer. The exposure of multiple nuclear targets to an identical neutrino beam allows for a systematic study of these nuclear effects. An analysis of the MINERνA DIS data on carbon, iron, lead and plastic scintillator has been conducted in the energy region 5 ≤ E ν < 50 GeV and thetamu < 17°. The data are presented as ratios of the total cross section (sigma(E ν)) as well as the differential cross section with respect to Bjorken-x (dsigma/dxbj) of carbon, iron and lead to scintillator. The total cross section data is useful for deciphering gross nuclear effects which effect neutrino energy reconstruction. No significant differences between simulation and MINνA DIS data are observed in the total cross section. The ratios of the xbj differential ratios however, may provide clues for decoding long standing questions about the EMC effect. The MINERνA data tend to

  11. Single Transverse Spin Asymmetry for Semi-Inclusive Deep Inelastic Scattering

    SciTech Connect

    Eguchi, Hisato; Koike, Yuji; Tanaka, Kazuhiro

    2007-06-13

    Establishing the twist-3 formalsim for the single transverse spin asymmetry, we present a complete single-spin-dependent cross section for SIDIS, ep{up_arrow} {yields} e{pi}X, associated with the twist-3 distribution for the transversely polarized nucleon. We emphasize that the consistency condition from the Ward identities for color gauge invariance is crucial to prove factorization property of the cross section.

  12. Simultaneous extraction of transversity and Collins functions from new semi-inclusive deep inelastic scattering and e{sup +}e{sup -} data

    SciTech Connect

    Anselmino, Mauro; Boglione, Mariaelena; D'Alesio, Umberto; Melis, Stefano; Murgia, Francesco; Prokudin, Alexei

    2013-05-01

    We present a global re-analysis of the most recent experimental data on azimuthal asymmetries in semi-inclusive deep inelastic scattering, from the HERMES and COMPASS Collaborations, and in e{sup +}e{sup -} {yields} h{sub 1} h{sub 2} X processes, from the Belle Collaboration. The transversity and the Collins functions are extracted simultaneously, in the framework of a revised global analysis in which a new parameterisation of the unknown functions is also tested.

  13. Measurement of “pretzelosity” asymmetry of charged pion production in semi-inclusive deep inelastic scattering on a polarized He3 target

    DOE PAGES

    Zhang, Y.; Qian, X.; Allada, K.; ...

    2014-11-24

    An experiment to measure single-spin asymmetries in semi-inclusive production of charged pions in deep-inelastic scattering on a transversely polarized ³He target was performed at Jefferson Lab in the kinematic region of 0.16 < x < 0.35 and 1.4 < Q² < 2.7 GeV². Our results show that both π± on 3He and on neutron pretzelosity asymmetries are consistent with zero within experimental uncertainties.

  14. Measurement of beauty production in deep inelastic scattering at HERA using decays into electrons

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Aushev, V.; Aushev, Y.; Bachynska, O.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Bartosik, N.; Bartsch, D.; Basile, M.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Bertolin, A.; Bhadra, S.; Bindi, M.; Blohm, C.; Bokhonov, V.; Bołd, T.; Bolilyi, O.; Boos, E. G.; Borras, K.; Boscherini, D.; Bot, D.; Boutle, S. K.; Brock, I.; Brownson, E.; Brugnera, R.; Brümmer, N.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bussey, P. J.; Butterworth, J. M.; Bylsma, B.; Caldwell, A.; Capua, M.; Carlin, R.; Catterall, C. D.; Chekanov, S.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; D'Agostini, G.; Dal Corso, F.; del Peso, J.; Dementiev, R. K.; De Pasquale, S.; Derrick, M.; Devenish, R. C. E.; Dobur, D.; Dolgoshein, B. A.; Dolinska, G.; Doyle, A. T.; Drugakov, V.; Durkin, L. S.; Dusini, S.; Eisenberg, Y.; Ermolov, P. F.; Eskreys, A.; Fang, S.; Fazio, S.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Forrest, M.; Foster, B.; Fourletov, S.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gialas, I.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Gogota, O.; Golubkov, Y. A.; Göttlicher, P.; Grabowska-Bołd, I.; Grebenyuk, J.; Gregor, I.; Grigorescu, G.; Grzelak, G.; Gueta, O.; Gwenlan, C.; Haas, T.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Hilger, E.; Hochman, D.; Hori, R.; Horton, K.; Hüttmann, A.; Iacobucci, G.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Jakob, H.-P.; Januschek, F.; Jimenez, M.; Jones, T. W.; Jüngst, M.; Kadenko, I.; Kahle, B.; Kamaluddin, B.; Kananov, S.; Kanno, T.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, M.; Kaur, P.; Keramidas, A.; Khein, L. A.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, U.; Koffeman, E.; Kooijman, P.; Korol, I.; Korzhavina, I. A.; Kotański, A.; Kötz, U.; Kowalski, H.; Kulinski, P.; Kuprash, O.; Kuze, M.; Lee, A.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Ling, T. Y.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Loizides, J. H.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Y.; Łużniak, P.; Maeda, J.; Magill, S.; Makarenko, I.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Martin, J. F.; Mastroberardino, A.; Mattingly, M. C. K.; Melzer-Pellmann, I.-A.; Mergelmeyer, S.; Miglioranzi, S.; Mohamad Idris, F.; Monaco, V.; Montanari, A.; Morris, J. D.; Mujkic, K.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Nicholass, D.; Nigro, A.; Ning, Y.; Noor, U.; Notz, D.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Oliver, K.; Olkiewicz, K.; Onishchuk, Y.; Papageorgiu, K.; Parenti, A.; Paul, E.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perlanski, W.; Perrey, H.; Piotrzkowski, K.; Plucinski, P.; Pokrovskiy, N. S.; Polini, A.; Proskuryakov, A. S.; Przybycień, M.; Raval, A.; Reeder, D. D.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Robertson, A.; Roloff, P.; Ron, E.; Rubinsky, I.; Ruspa, M.; Sacchi, R.; Salii, A.; Samson, U.; Sartorelli, G.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schneekloth, U.; Schönberg, V.; Schörner-Sadenius, T.; Schwartz, J.; Sciulli, F.; Shcheglova, L. M.; Shehzadi, R.; Shimizu, S.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Smith, W. H.; Sola, V.; Solano, A.; Son, D.; Sosnovtsev, V.; Spiridonov, A.; Stadie, H.; Stanco, L.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stopa, P.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tapper, A. D.; Tassi, E.; Terrón, J.; Theedt, T.; Tiecke, H.; Tokushuku, K.; Tomalak, O.; Tomaszewska, J.; Tsurugai, T.; Turcato, M.; Tymieniecka, T.; Uribe-Estrada, C.; Vázquez, M.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Volynets, O.; Walczak, R.; Wan Abdullah, W. A. T.; Whitmore, J. J.; Whyte, J.; Wiggers, L.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Yagües-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zeuner, W.; Zhautykov, B. O.; Zhmak, N.; Zhou, C.; Zichichi, A.; Zolko, M.; Zotkin, D. S.; Zulkapli, Z.

    2011-02-01

    The production of beauty quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared Q 2>10 GeV2, using an integrated luminosity of 363 pb-1. The beauty events were identified using electrons from semileptonic b decays with a transverse momentum 0.9 < pTe < 8 GeV and pseudorapidity | η e |<1.5. Cross sections for beauty production were measured and compared with next-to-leading-order QCD calculations. The beauty contribution to the proton structure function F 2 was extracted from the double-differential cross section as a function of Bjorken- x and Q 2.

  15. Polarized gluon distributions from high-pT pair hadron productions in polarized deep inelastic scattering

    NASA Astrophysics Data System (ADS)

    Yamanishi, Teruya; Yu-Bing, Dong; Morii, Toshiyuki

    2001-06-01

    To study the polarized gluon density Δg(x) in the nucleon, we propose the high-pT pair charmed hadron production process in polarized lp scattering. The double spin asymmetry ALL for this process is a good observable for testing the models of Δg(x). .

  16. Hadron mass corrections in semi-inclusive deep-inelastic scattering

    SciTech Connect

    Guerrero Teran, Juan Vicente; Ethier, James J.; Accardi, Alberto; Casper, Steven W.; Melnitchouk, Wally

    2015-09-24

    We found that the spin-dependent cross sections for semi-inclusive lepton-nucleon scattering are derived in the framework of collinear factorization, including the effects of masses of the target and produced hadron at finite Q2. At leading order the cross sections factorize into products of parton distribution and fragmentation functions evaluated in terms of new, mass-dependent scaling variables. Furthermore, the size of the hadron mass corrections is estimated at kinematics relevant for current and future experiments, and the implications for the extraction of parton distributions from semi-inclusive measurements are discussed.

  17. Hadron mass corrections in semi-inclusive deep-inelastic scattering

    DOE PAGES

    Guerrero Teran, Juan Vicente; Ethier, James J.; Accardi, Alberto; ...

    2015-09-24

    We found that the spin-dependent cross sections for semi-inclusive lepton-nucleon scattering are derived in the framework of collinear factorization, including the effects of masses of the target and produced hadron at finite Q2. At leading order the cross sections factorize into products of parton distribution and fragmentation functions evaluated in terms of new, mass-dependent scaling variables. Furthermore, the size of the hadron mass corrections is estimated at kinematics relevant for current and future experiments, and the implications for the extraction of parton distributions from semi-inclusive measurements are discussed.

  18. Study of deep inelastic scattering of polarized electrons off polarized deuterons

    SciTech Connect

    Kuriki, M.

    1996-03-01

    This thesis describes a 29GeV electron - nucleon scattering experiment carried out at Stanford Linear Accelerator Center (SLAC). Highly polarized electrons are scattered off a polarized ND{sub 3} target. Scattered electrons are detected by two spectrometers located in End Station A (ESA) at angles of 4.5{degrees} and 7{degrees} with respect to the beam axis. We have measured the spin structure function g{sub 1} of deuteron over the range of 0.029 < x < 0.8 and 1. 0 < Q{sup 2} < 12.0(GeV/c){sup 2}. This integral indicates a discrepancy of more than three standard deviations from the prediction of the Ellis-Jaffe sum rule, 0.068{+-}0.005 at Q{sup 2} = 3.0(GeV/c){sup 2} while our result of g{sub 1}{sup d} in good agreement with SMC results. Combined with g{sub 1} of the proton, the measurement of {integral}{sub 0}{sup 1}(g{sub 1}{sup d}-g{sub 1}{sup n}) is 0.169{+-}0.008. We also obtained the strong coupling constant at Q{sup 2} = 3.0(GeV/c){sup 2} to be 0.417{sub -0.110}{sup +0.086}, using the power correction for the sum rule up to third order of {alpha}{sub s}. This result is in agreement with the strong coupling constant {alpha}{sub s}(Q{sup 2}) = 3.0(GeV/c{sup 2}) obtained from various experiments. Using our deuteron results and the axial vector couplings of hyperon decays, the total quark polarization along the nucleon spin is found to be 0.286{+-}.055, implying that quarks carry only 30% of the nucleon spin. The strange sea quark polarization is also determined to be -0.101 {+-} .023. These measurements are in agreement with other experiments and provide the world`s most precise measurement of these quark polarizations. 80 refs., 151 figs., 23 tabs.

  19. Time reversal odd fragmentation functions in semi-inclusive deep inelastic lepton-hadron scattering

    SciTech Connect

    Mulders, P.J.; Levelt, J.

    1994-04-01

    In semi-inclusive scattering of polarized leptons from unpolarized hadrons, one can measure a time reversal odd structure function. It shows up as a sin({phi}) asymmetry of the produced hadrons. This asymmetry can be expressed as the product of a twist-three {open_quotes}hadron {r_arrow} quark{close_quotes} profile function and a time reversal odd twist-two {open_quotes}quark {r_arrow} hadron{close_quotes} fragmentation function. This fragmentation function can only be measured for nonzero transverse momenta of the produced hadron. Its appearance is a consequence of final state interactions between the produced hadron and the rest of the final state.

  20. Transverse momentum broadening in semi-inclusive deep inelastic scattering at next-to-leading order

    NASA Astrophysics Data System (ADS)

    Kang, Zhong-Bo; Wang, Enke; Wang, Xin-Nian; Xing, Hongxi

    2016-12-01

    Within the framework of higher-twist collinear factorization, transverse momentum broadening for the final hadrons in semi-inclusive deeply inelastic e +A collisions is studied at the next-to-leading order (NLO) in perturbative QCD. Through explicit calculations of real and virtual corrections at twist 4, the transverse-momentum-weighted differential cross section due to double scattering is shown to factorize at NLO and can be expressed as a convolution of twist-4 nuclear parton correlation functions, the usual twist-2 fragmentation functions and hard parts which are finite and free of any divergences. A QCD evolution equation is also derived for the renormalized twist-4 quark-gluon correlation function which can be applied to future phenomenological studies of transverse momentum broadening and jet quenching at NLO.

  1. Structure Functions in Deep Inelastic Lepton Scattering: Data from DOE laboratory experiments as compiled in data reviews by the Durham High Energy Physics Database Group

    DOE Data Explorer

    Gehrmann, T; Roberts, R. G.; Whalley, M. R.; Durham HEP Database Group

    Gehrmann, Roberts, and Whalley in their 1999 paper, A Compilation of Structure Functions in Deep Inelastic Scattering, published in volume 25 of Journal of Physics G (Nuclear and Particle Physics) note that these data will continue to be relevant to the next generation of hadron colliders. They present data on the unpolarized structure functions F2 and xF3, R D ._L=_T /, the virtual photon asymmetries A1 and A2 and the polarized structure functions g1 and g2, from deep inelastic lepton scattering off protons, deuterium and nuclei. Data are presented in both tabular and graphical format and include predictions based on the MRST98 and CTEQ4 parton distribution functionsö as well. The data gathered from the relevant collaborations at DOE's Fermilab, SLAC, and JLAB are available, and so are data from related collaborations based at CERN and DESY. The Durham High Energy Physics (HEP) Database Group makes these data, extracted from papers and data reviews, available in one place in an easy-to-access format. These data are also include in the Durham HEP Reaction Data Database which can be searched at http://hepdata.cedar.ac.uk/reaction

  2. Measurement of the Target-Normal Single-Spin Asymmetry in Deep-Inelastic Scattering from the Reaction 3He{uparrow}(e,e')X

    SciTech Connect

    Katich, Joseph; Qian, Xin; Zhao, Yuxiang; Allada, Kalyan; Aniol, Konrad; Annand, John; Averett, Todd; Benmokhtar, Fatiha; Bertozzi, William; Bradshaw, Elliott; Bosted, Peter; Camsonne, Alexandre; Canan, Mustafa; Cates, Gordon; Chen, Chunhua; Chen, Jian-Ping; Chen, Wei; Chirapatpimol, Khem; Chudakov, Eugene; Cisbani, Evaristo; Cornejo, Juan; Cusanno, Francesco; Dalton, Mark; Deconinck, Wouter; De Jager, Cornelis; De Leo, Raffaele; Deng, Xiaoyan; Deur, Alexandre; Ding, Huaibo; Dolph, Peter; Dutta, Chiranjib; Dutta, Dipangkar; El Fassi, Lamiaa; Frullani, Salvatore; Gao, Haiyan; Garibaldi, Franco; Gaskell, David; Gilad, Gilad; Gilman, Ronald; Glamazdin, Oleksandr; Golge, Serkan; Guo, Lei; Hamilton, David; Hansen, Jens-Ole; Higinbotham, Douglas; Holmstrom, Timothy; Huang, Jijun; Huang, Min; Ibrahim Abdalla, Hassan; Iodice, Mauro; Jin, Ge; Jones, Mark; Kelleher, Aidan; Kim, Wooyoung; Kolarkar, Ameya; Korsch, Wolfgang; LeRose, John; Li, Xiaomei; Li, Y; Lindgren, Richard; Liyanage, Nilanga; Long, Elena; Lu, Hai-jiang; Margaziotis, Demetrius; Markowitz, Pete; Marrone, Stefano; McNulty, Dustin; Meziani, Zein-Eddine; Michaels, Robert; Moffit, Bryan; Munoz Camacho, Carlos; Nanda, Sirish; Narayan, Amrendra; Nelyubin, Vladimir; Norum, Blaine; Oh, Yoomin; Osipenko, Mikhail; Parno, Diana; Peng, Jen-chieh; Phillips, Sarah; Posik, Matthew; Puckett, Andrew; Qiang, Yi; Rakhman, Abdurahim; Ransome, Ronald; Riordan, Seamus; Saha, Arunava; Sawatzky, Bradley; Schulte, Elaine; Shahinyan, Albert; Hashemi Shabestari, Mitra; Sirca, Simon; Stepanyan, Stepan; Subedi, Ramesh; Sulkosky, Vincent; Tang, Liguang; Tobias, William; Urciuoli, Guido; Vilardi, Ignazio; Wang, Kebin; Wang, Y; Wojtsekhowski, Bogdan; Yan, X; Yao, Huan; Ye, Yunxiu; Ye, Z; Yuan, Lulin; Zhan, Xiaohui; Zhang, Yi; Zhang, Y -W; Zhao, Bo; Zheng, Xiaochao; Zhu, Lingyan; Zhu, Xiaofeng; Zong, Xing

    2014-07-01

    We report the first measurement of the target single-spin asymmetry in deep-inelastic scattering from the inclusive reaction 3He{uparrow}(e,e')X on a 3He gas target polarized normal to the lepton plane. Assuming time-reversal invariance, this asymmetry is strictly zero in the Born approximation. The experiment, conducted at Jefferson Lab using a 5.89 GeV electron beam, covers a range of 1.72 GeV, which is non-zero at the 2.75sigma level. Theoretical calculations, which assume two-photon exchange with quasi-free quarks, predict a neutron asymmetry of O(10−4) when both photons couple to one quark, and O(10−2) for the photons coupling to different quarks. Our measured asymmetry agrees both in sign and magnitude with the prediction that uses input based on the Sivers transverse momentum distribution obtained from semi-inclusive deep-inelastic scattering.

  3. A high-statistics measurement of transverse spin effects in dihadron production from muon-proton semi-inclusive deep-inelastic scattering

    NASA Astrophysics Data System (ADS)

    Adolph, C.; Akhunzyanov, R.; Alekseev, M. G.; Alexandrov, Yu.; Alexeev, G. D.; Amoroso, A.; Andrieux, V.; Anosov, V.; Austregesilo, A.; Badełek, B.; Balestra, F.; Barth, J.; Baum, G.; Beck, R.; Bedfer, Y.; Berlin, A.; Bernhard, J.; Bertini, R.; Bicker, K.; Bieling, J.; Birsa, R.; Bisplinghoff, J.; Bodlak, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bravar, A.; Bressan, A.; Büchele, M.; Burtin, E.; Capozza, L.; Chiosso, M.; Chung, S. U.; Cicuttin, A.; Crespo, M. L.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S. S.; Dasgupta, S.; Denisov, O. Yu.; Donskov, S. V.; Doshita, N.; Duic, V.; Dünnweber, W.; Dziewiecki, M.; Efremov, A.; Elia, C.; Eversheim, P. D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Filin, A.; Finger, M.; Finger, M.; Fischer, H.; Franco, C.; du Fresne von Hohenesche, N.; Friedrich, J. M.; Frolov, V.; Garfagnini, R.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Geyer, R.; Giorgi, M.; Gnesi, I.; Gobbo, B.; Goertz, S.; Gorzellik, M.; Grabmüller, S.; Grasso, A.; Grube, B.; Guskov, A.; Guthörl, T.; Haas, F.; von Harrach, D.; Hahne, D.; Hashimoto, R.; Heinsius, F. H.; Herrmann, F.; Hinterberger, F.; Höppner, Ch.; Horikawa, N.; d'Hose, N.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jary, V.; Jasinski, P.; Joerg, P.; Joosten, R.; Kabuß, E.; Kang, D.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Yu. A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Königsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O.; Kral, Z.; Krämer, M.; Kroumchtein, Z. V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levorato, S.; Lichtenstadt, J.; Maggiora, A.; Magnon, A.; Makke, N.; Mallot, G. K.; Marchand, C.; Martin, A.; Marzec, J.; Matousek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Miyachi, Y.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neubert, S.; Neyret, D.; Nikolaenko, V. I.; Novy, J.; Nowak, W.-D.; Nunes, A. S.; Orlov, I.; Olshevsky, A. G.; Ostrick, M.; Panknin, R.; Panzieri, D.; Parsamyan, B.; Paul, S.; Pesek, M.; Peshekhonov, D.; Piragino, G.; Platchkov, S.; Pochodzalla, J.; Polak, J.; Polyakov, V. A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Reicherz, G.; Rocco, E.; Rodionov, V.; Rondio, E.; Rychter, A.; Rossiyskaya, N. S.; Ryabchikov, D. I.; Samoylenko, V. D.; Sandacz, A.; Sarkar, S.; Savin, I. A.; Sbrizzai, G.; Schiavon, P.; Schill, C.; Schlüter, T.; Schmidt, A.; Schmidt, K.; Schmieden, H.; Schönning, K.; Schopferer, S.; Schott, M.; Shevchenko, O. Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Sosio, S.; Sozzi, F.; Srnka, A.; Steiger, L.; Stolarski, M.; Sulc, M.; Sulej, R.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; ter Wolbeek, J.; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Uhl, S.; Uman, I.; Vandenbroucke, M.; Virius, M.; Vondra, J.; Wang, L.; Weisrock, T.; Wilfert, M.; Windmolders, R.; Wiślicki, W.; Wollny, H.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.

    2014-09-01

    A measurement of the azimuthal asymmetry in dihadron production in deep-inelastic scattering of muons on transversely polarised proton (NH3) targets is presented. They provide independent access to the transversity distribution functions through the measurement of the Collins asymmetry in single hadron production. The data were taken in the year 2010 with the COMPASS spectrometer using a 160 GeV/c muon beam of the CERN SPS, increasing by a factor of about four the overall statistics with respect to the previously published data taken in the year 2007. The measured sizeable asymmetry is in good agreement with the published data. An approximate equality of the Collins asymmetry and the dihadron asymmetry is observed, suggesting a common physical mechanism in the underlying fragmentation.

  4. Single spin asymmetries in charged kaon production from semi-inclusive deep inelastic scattering on a transversely polarized He3 target

    DOE PAGES

    Zhao, Y. X.; Wang, Y.; Allada, K.; ...

    2014-11-03

    We report the first measurement of target single spin asymmetries of charged kaons produced in semi-inclusive deep inelastic scattering of electrons off a transversely polarized 3He target. Both the Collins and Sivers moments, which are related to the nucleon transversity and Sivers distributions, respectively, are extracted over the kinematic range of 0.1 < xbj<0.4 for K+ and K– production. While the Collins and Sivers moments for K+ are consistent with zero within the experimental uncertainties, both moments for K– favor negative values. The Sivers moments are compared to the theoretical prediction from a phenomenological fit to the world data. Whilemore » the K+ Sivers moments are consistent with the prediction, the K– results differ from the prediction at the 2-sigma level.« less

  5. Single/Double-Spin Asymmetry Measurements of Semi-Inclusive Pion Electroproduction on a Transversely Polarized 3He Target through Deep Inelastic Scattering

    SciTech Connect

    Xin Qian

    2012-06-01

    Parton distribution functions, which represent the flavor and spin structure of the nucleon, provide invaluable information in illuminating quantum chromodynamics in the confinement region. Among various processes that measure such parton distribution functions, semi-inclusive deep inelastic scattering is regarded as one of the golden channels to access transverse momentum dependent parton distribution functions, which provide a 3-D view of the nucleon structure in momentum space. The Jefferson Lab experiment E06-010 focuses on measuring the target single and double spin asymmetries in the 3He(e, e'pi+,-)X reaction with a transversely polarized 3He target in Hall A with a 5.89 GeV electron beam. A leading pion and the scattered electron are detected in coincidence by the left High-Resolution Spectrometer at 16{sup o} and the BigBite spectrometer at 30{sup o} beam right, respectively. The kinematic coverage concentrates in the valence quark region, x {approx} 0.1-0.4, at Q2 {approx}1-3 Gev{sub 2}. The Collins and Sivers asymmetries of 3He and neutron are extracted. In this review, an overview of the experiment and the final results are presented. Furthermore, an upcoming 12-GeV program with a large acceptance solenoidal device and the future possibilities at an electron-ion collider are discussed.

  6. Next-to-leading order transverse momentum-weighted Sivers asymmetry in semi-inclusive deep inelastic scattering: The role of the three-gluon correlator

    DOE PAGES

    Dai, Ling -Yun; Kang, Zhong -Bo; Prokudin, Alexei; ...

    2015-12-22

    Here, we study the Sivers asymmetry in semi-inclusive hadron production in deep inelastic scattering. We concentrate on the contribution from the photon-gluon fusion channel at O(αem2αs), where three-gluon correlation functions play a major role within the twist-3 collinear factorization formalism. We establish the correspondence between such a formalism with three-gluon correlation functions and the usual transverse momentum-dependent (TMD) factorization formalism at moderate hadron transverse momenta. We derive the coefficient functions used in the usual TMD evolution formalism related to the quark Sivers function expansion in terms of the three-gluon correlation functions. We further perform the next-to-leading order calculation for themore » transverse momentum-weighted spin-dependent differential cross section and identify the off-diagonal contribution from the three-gluon correlation functions to the QCD collinear evolution of the twist-3 Qiu-Sterman function.« less

  7. Next-to-leading order transverse momentum-weighted Sivers asymmetry in semi-inclusive deep inelastic scattering: The role of the three-gluon correlator

    SciTech Connect

    Dai, Ling -Yun; Kang, Zhong -Bo; Prokudin, Alexei; Vitev, Ivan

    2015-12-22

    Here, we study the Sivers asymmetry in semi-inclusive hadron production in deep inelastic scattering. We concentrate on the contribution from the photon-gluon fusion channel at O(αem2αs), where three-gluon correlation functions play a major role within the twist-3 collinear factorization formalism. We establish the correspondence between such a formalism with three-gluon correlation functions and the usual transverse momentum-dependent (TMD) factorization formalism at moderate hadron transverse momenta. We derive the coefficient functions used in the usual TMD evolution formalism related to the quark Sivers function expansion in terms of the three-gluon correlation functions. We further perform the next-to-leading order calculation for the transverse momentum-weighted spin-dependent differential cross section and identify the off-diagonal contribution from the three-gluon correlation functions to the QCD collinear evolution of the twist-3 Qiu-Sterman function.

  8. Collective phenomena in pp and ep scattering

    NASA Astrophysics Data System (ADS)

    Celiberto, Francesco Giovanni; Fiore, Roberto; Jenkovszky, László

    2017-03-01

    Bjorken scaling violation in deep inelastic electron-proton scattering (DIS) is related to the rise of hadronic cross sections by using the additive quark model. Of special interest is the connection between saturation in the low-x behavior of the DIS structure functions (SF) and possible slow-down of the pp cross section rise due to saturation effects. We also identify saturation effects in the DIS SF with phase transition that can be described by the Van der Waals equation of state.

  9. Measurement of Single Spin Asymmetries in Semi-Inclusive Deep Inelastic Scattering Reaction n(e, e'π+) X at Jefferson Lab

    SciTech Connect

    Allada, Kalyan

    2010-06-01

    What constitutes the spin of the nucleon? The answer to this question is still not completely understood. Although we know the longitudinal quark spin content very well, the data on the transverse quark spin content of the nucleon is still very sparse. Semi-inclusive Deep Inelastic Scattering (SIDIS) using transversely polarized targets provide crucial information on this aspect. The data that is currently available was taken with proton and deuteron targets. The E06-010 experiment was performed at Jefferson Lab in Hall-A to measure the single spin asymmetries in the SIDIS reaction n(e, e'π±/K±)X using transversely polarized 3He target. The experiment used the continuous electron beam provided by the CEBAF accelerator with a beam energy of 5.9 GeV. Hadrons were detected in a high-resolution spectrometer in coincidence with the scattered electrons detected by the BigBite spectrometer. The kinematic coverage focuses on the valence quark region, x = 0.19 to 0.34, at Q2 = 1.77 to 2.73 (GeV/c)2. This is the first measurement on a neutron target. The data from this experiment, when combined with the world data on the proton and the deuteron, will provide constraints on the transversity and Sivers distribution functions on both the u and d-quarks in the valence region. In this work we report on the single spin asymmetries in the SIDIS n(e, e'π+)X reaction.

  10. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A. N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E. G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R. K.; Devenish, R. C. E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L. A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J. F.; Mergelmeyer, S.; Mohamad Idris, F.; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R. J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N. S.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schneekloth, U.; Schörner-Sadenius, T.; Schwartz, J.; Shcheglova, L. M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zhmak, N.; Zotkin, D. S.

    2014-09-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q 2 < 1000 GeV2 using an integrated luminosity of 354 pb-1. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q 2, Bjorken x, jet trans- verse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q 2. The running beauty-quark mass, m b at the scale m b , was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m b ( m b ) = 4.07 ± 0.14 (fit){-/0.07 + 0.01}(mod.){-/0.00 + 0.05}(param.){-/0.05 + 0.08}(theo.) GeV.

  11. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A. N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E. G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R. K.; Devenish, R. C. E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L. A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J. F.; Mergelmeyer, S.; Mohamad Idris, F.; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R. J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N. S.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schneekloth, U.; Schörner-Sadenius, T.; Schwartz, J.; Shcheglova, L. M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zhmak, N.; Zotkin, D. S.

    2014-10-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q 2 < 1000 GeV2 using an integrated luminosity of 354 pb-1. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q 2, Bjorken x, jet trans- verse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q 2. The running beauty-quark mass, m b at the scale m b , was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m b ( m b ) = 4.07 ± 0.14 (fit){-/0.07 + 0.01}(mod.){-/0.00 + 0.05}(param.){-/0.05 + 0.08}(theo.) GeV.

  12. Virtual Compton scattering and neutral pion electroproduction in the resonance region up to the deep inelastic region at backward angles

    SciTech Connect

    Laveissiere, Geraud; Degrande, Natalie; Jaminion, Stephanie; Jutier, Christophe; Todor, Luminita; Di Salvo, Rachele; Van Hoorebeke, L.; Alexa, L.C.; Anderson, Brian; Aniol, Konrad; Arundell, Kathleen; Audit, Gerard; Auerbach, Leonard; Baker, F.; Baylac, Maud; Berthot, J.; Bertin, Pierre; Bertozzi, William; Bimbot, Louis; Boeglin, Werner; Brash, Edward; Breton, Vincent; Breuer, Herbert; Burtin, Etienne; Calarco, John; Cardman, Lawrence; Cavata, Christian; Chang, C.; Chang, C.C.; Chang, C.; Chang, C.C.; Chang, C.; Chang, C.C.; Chang, C.; Chang, C.C.; Chen, Jian-Ping; Chudakov, Eugene; Cisbani, Evaristo; Dale, Daniel; De Jager, Cornelis; De Leo, Raffaele; Deur, Alexandre; D'Hose, Nicole; Dodge, Gail; Domingo, John; Elouadrhiri, Latifa; Epstein, Martin; Ewell, Lars; Finn, John; Fissum, Kevin; Fonvieille, Helene; Fournier, Guy; Frois, Bernard; Frullani, Salvatore; Furget, Christophe; Gao, Haiyan; Gao, Juncai; Garibaldi, Franco; Gasparian, Ashot; Gilad, Shalev; Gilman, Ronald; Glamazdin, Oleksandr; Glashausser, Charles; Gomez, Javier; Gorbenko, Viktor; Grenier, Philippe; Guichon, Pierre; Hansen, Jens-Ole; Holmes, Richard; Holtrop, Maurik; Howell, Calvin; Huber, Garth; Hyde, Charles; Incerti, Sebastien; Iodice, Mauro; Jardillier, Johann; Jones, Mark; Kahl, William; Kamalov, Sabit; Kato, Seigo; Katramatou, A.T.; Kelly, James; Kerhoas, Sophie; Ketikyan, Armen; Khayat, Mohammad; Kino, Kouichi; Kox, Serge; Kramer, Laird; Kumar, Krishna; Kumbartzki, Gerfried; Kuss, Michael; Leone, Antonio; LeRose, John; Liang, Meihua; Lindgren, Richard; Liyanage, Nilanga; Lolos, George; Lourie, Robert; Madey, Richard; Maeda, Kazushige; Malov, Sergey; Manley, D.; Marchand, Claude; Marchand, Dominique; Margaziotis, Demetrius; Markowitz, Pete; Marroncle, Jacques; Martino, Jacques; McCormick, Kathy; McIntyre, Justin; Mehrabyan, Surik; Merchez, Fernand; Meziani, Zein-Eddine; Michaels, Robert; Miller, Gerald; Mougey, Jean; Nanda, Sirish; Neyret, Damien; Offermann, Edmond; Papandreou, Zisis; Perdrisat, Charles; Perrino, R.; Petratos, Gerassimos; Platchkov, Stephane; Pomatsalyuk, Roman; Prout, David; Punjabi, Vina; Pussieux, Thierry; Quemener, Gilles; Ransome, Ronald; Ravel, Oliver; Real, Jean-Sebastien; Renard, F.; Roblin, Yves; Rowntree, David; Rutledge, Gary; Rutt, Paul; Saha, Arunava; Saito, Teijiro; Sarty, Adam; Serdarevic, A.; Smith, T.; Smirnov, G.; Soldi, K.; Sorokin, Pavel; Souder, Paul; Suleiman, Riad; Templon, Jeffrey; Terasawa, Tatsuo; Tiator, Lothar; Tieulent, Raphael; Tomasi-Gustaffson, E.; Tsubota, Hiroaki; Ueno, Hiroaki; Ulmer, Paul; Urciuoli, Guido; Van De Vyver, R.; van der Meer, Rob; Vernin, Pascal; Vlahovic, B.; Voskanyan, Hakob; Voutier, Eric; Watson, J.W.; Weinstein, Lawrence; Wijesooriya, Krishni; Wilson, R.; Wojtsekhowski, Bogdan; Zainea, Dan; Zhang, Wei-Ming; Zhao, Jie; Zhou, Z.-L.

    2009-01-01

    We have made the first measurements of the virtual Compton scattering (VCS) process via the H(e,e'p)? exclusive reaction in the nucleon resonance region, at backward angles. Results are presented for the W-dependence at fixed Q2=1 GeV2, and for the Q2-dependence at fixed W near 1.5 GeV. The VCS data show resonant structures in the first and second resonance regions. The observed Q2-dependence is smooth. The measured ratio of H(e,e'p)? to H(e,e'p)?0 cross sections emphasizes the different sensitivity of these two reactions to the various nucleon resonances. Finally, when compared to Real Compton Scattering (RCS) at high energy and large angles, our VCS data at the highest W (1.8-1.9 GeV) show a striking Q2-independence, which may suggest a transition to a perturbative scattering mechanism at the quark level.

  13. Measurement of the A-dependence of the EMC effect and R in deep-inelastic electron scattering from nuclei

    SciTech Connect

    Rock, S.E.

    1984-08-01

    Significant differences in the inelastic structure functions of Fe, Al, and deuterium nuclei have recently been observed in muon and electron scattering experiments. This has been interpreted as a distortion of the quark momentum distributions in bound nucleons. To study the A-dependence of this effect, we have measured differential cross sections for the inelastic scattering of electrons from deuterium, He, Be, C, Al, Ca, Fe, Ag, and Au over a large kinematic range (x values between 0.09 and 0.9 and Q/sup 2/ values of 2, 5, 10, and 15 (GeV/c)/sup 2/). The Stanford Linear Accelerator Center (SLAC) provided electrons with incident energies (E) ranging from 8 to 24.5 GeV. The SLAC 8-GeV/c spectrometer was used at 23 settings to detect electrons with energies (E') from 3.1 to 8.4 GeV scattered at angles (theta) between 11 and 23/sup 0/.

  14. Virtual Compton scattering and neutral pion electroproduction in the resonance region up to the deep inelastic region at backward angles

    SciTech Connect

    Laveissiere, G.; Jaminion, S.; Salvo, R. Di; Berthot, J.; Bertin, P. Y.; Breton, V.; Fonvieille, H.; Grenier, P.; Ravel, O.; Roblin, Y.; Smirnov, G.; Jutier, C.; Hyde, C. E.; Todor, L.; Dodge, G. E.; McCormick, K.; Ulmer, P. E.

    2009-01-15

    We have made the first measurements of the virtual Compton scattering (VCS) process via the H(e, e{sup '}p){gamma} exclusive reaction in the nucleon resonance region, at backward angles. Results are presented for the W-dependence at fixed Q{sup 2}=1 GeV{sup 2} and for the Q{sup 2} dependence at fixed W near 1.5 GeV. The VCS data show resonant structures in the first and second resonance regions. The observed Q{sup 2} dependence is smooth. The measured ratio of H(e, e{sup '}p){gamma} to H(e, e{sup '}p){pi}{sup 0} cross sections emphasizes the different sensitivity of these two reactions to the various nucleon resonances. Finally, when compared to real Compton scattering (RCS) at high energy and large angles, our VCS data at the highest W (1.8-1.9 GeV) show a striking Q{sup 2} independence, which may suggest a transition to a perturbative scattering mechanism at the quark level.

  15. Recovery Act - Measurement of Parity Violation in Deep Inelastic Scattering and Studies of the Nucleon Spin Structure at JLab 6 and 11 GeV

    SciTech Connect

    Zheng, Xiaochao

    2016-03-10

    The program proposed contains two ingredients which aim to address aspects of two of the three research frontiers of nuclear science as identified in the 2007 NSAC Long Range Plan. The first topic, a test of the current Standard Model, is an ongoing project focusing on measurements of the parity-violating asymmetry in ~e-2H deep inelastic scattering (PVDIS). The PVDIS measurement is complementary to other completed or ongoing low- to medium-energy tests of the Standard Model. As the first, exploratory, step, an experiment using a 6 GeV electron beam will be carried out from October to December 2009 at the Thomas Jefferson National Accelerator Facility (JLab). Meanwhile, a program using the upgraded JLab 11 GeV beam is being planned. The PVDIS program as a whole will provide the first precision data on the axial quark neutral-weak coupling constants. This will either put the current Standard Model to a test that has never been done before, or reveal information on where to look for New Physics beyond the current Standard Model. The PVDIS program will also provide results on hadronic physics effects such as charge symmetry violation. The second part of the proposed program uses spin observables to address the research frontier concerning QCD and structure of the nucleon. An experiment using the JLab 6 GeV beam in 2001 showed that, contrary to predictions from perturbative quantum chromodynamics (pQCD), while the valence up quark’s spin is parallel to the nucleon’s spin, the valence down quark’s spin is not. In order to test the limit of QCD in describing the nucleon spin structure to a region beyond the 6 GeV kinematics, this measurement will be extended to a more energetic, “deeper” valence quark region using the upgraded JLab 11 GeV beam with a polarized 3He target. Although the two topics of the proposed program appear to focus on different physics, for the upgraded JLab 11 GeV beam, both will utilize a new, yet-to-be-built large acceptance

  16. Combination of measurements of inclusive deep inelastic {e^{± }p} scattering cross sections and QCD analysis of HERA data. H1 and ZEUS Collaborations

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Andreev, V.; Antonelli, S.; Antunović, B.; Aushev, V.; Aushev, Y.; Baghdasaryan, A.; Begzsuren, K.; Behnke, O.; Behrendt Dubak, A.; Behrens, U.; Belousov, A.; Belov, P.; Bertolin, A.; Bloch, I.; Boos, E. G.; Borras, K.; Boudry, V.; Brandt, G.; Brisson, V.; Britzger, D.; Brock, I.; Brook, N. H.; Brugnera, R.; Bruni, A.; Buniatyan, A.; Bussey, P. J.; Bylinkin, A.; Bystritskaya, L.; Caldwell, A.; Campbell, A. J.; Cantun Avila, K. B.; Capua, M.; Catterall, C. D.; Ceccopieri, F.; Cerny, K.; Chekelian, V.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Contreras, J. G.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; Cvach, J.; Dainton, J. B.; Daum, K.; Dementiev, R. K.; Devenish, R. C. E.; Diaconu, C.; Dobre, M.; Dodonov, V.; Dolinska, G.; Dusini, S.; Eckerlin, G.; Egli, S.; Elsen, E.; Favart, L.; Fedotov, A.; Feltesse, J.; Ferencei, J.; Figiel, J.; Fleischer, M.; Fomenko, A.; Foster, B.; Gabathuler, E.; Gach, G.; Gallo, E.; Garfagnini, A.; Gayler, J.; Geiser, A.; Ghazaryan, S.; Gizhko, A.; Gladilin, L. K.; Goerlich, L.; Gogitidze, N.; Golubkov, Yu. A.; Gouzevitch, M.; Grab, C.; Grebenyuk, A.; Grebenyuk, J.; Greenshaw, T.; Gregor, I.; Grindhammer, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Gwenlan, C.; Haidt, D.; Hain, W.; Henderson, R. C. W.; Henkenjohann, P.; Hladkỳ, J.; Hochman, D.; Hoffmann, D.; Hori, R.; Horisberger, R.; Hreus, T.; Huber, F.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Jacquet, M.; Janssen, X.; Januschek, F.; Jomhari, N. Z.; Jung, H.; Kadenko, I.; Kananov, S.; Kapichine, M.; Karshon, U.; Katzy, J.; Kaur, M.; Kaur, P.; Kiesling, C.; Kisielewska, D.; Klanner, R.; Klein, M.; Klein, U.; Kleinwort, C.; Kogler, R.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kostka, P.; Kotański, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kretzschmar, J.; Krücker, D.; Krüger, K.; Krupa, B.; Kuprash, O.; Kuze, M.; Landon, M. P. J.; Lange, W.; Laycock, P.; Lebedev, A.; Levchenko, B. B.; Levonian, S.; Levy, A.; Libov, V.; Limentani, S.; Lipka, K.; Lisovyi, M.; List, B.; List, J.; Lobodzinska, E.; Lobodzinski, B.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Makarenko, I.; Malinovski, E.; Malka, J.; Martyn, H.-U.; Maxfield, S. J.; Mehta, A.; Mergelmeyer, S.; Meyer, A. B.; Meyer, H.; Meyer, J.; Mikocki, S.; Mohamad Idris, F.; Morozov, A.; Muhammad Nasir, N.; Müller, K.; Myronenko, V.; Nagano, K.; Naumann, Th.; Newman, P. R.; Niebuhr, C.; Nikiforov, A.; Nobe, T.; Notz, D.; Nowak, G.; Nowak, R. J.; Olsson, J. E.; Onishchuk, Yu.; Ozerov, D.; Pahl, P.; Pascaud, C.; Patel, G. D.; Paul, E.; Perez, E.; Perlański, W.; Petrukhin, A.; Picuric, I.; Pirumov, H.; Pitzl, D.; Pokorny, B.; Pokrovskiy, N. S.; Polifka, R.; Przybycień, M.; Radescu, V.; Raicevic, N.; Ravdandorj, T.; Reimer, P.; Rizvi, E.; Robmann, P.; Roloff, P.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Rubinsky, I.; Rusakov, S.; Ruspa, M.; Šálek, D.; Sankey, D. P. C.; Sauter, M.; Sauvan, E.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schmitt, S.; Schneekloth, U.; Schoeffel, L.; Schöning, A.; Schörner-Sadenius, T.; Sefkow, F.; Shcheglova, L. M.; Shevchenko, R.; Shkola, O.; Shushkevich, S.; Shyrma, Yu.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Solano, A.; Soloviev, Y.; Sopicki, P.; South, D.; Spaskov, V.; Specka, A.; Stanco, L.; Steder, M.; Stefaniuk, N.; Stella, B.; Stern, A.; Stopa, P.; Straumann, U.; Sykora, T.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Thompson, P. D.; Tokushuku, K.; Tomaszewska, J.; Traynor, D.; Trofymov, A.; Truöl, P.; Tsakov, I.; Tseepeldorj, B.; Tsurugai, T.; Turcato, M.; Turkot, O.; Turnau, J.; Tymieniecka, T.; Valkárová, A.; Vallée, C.; Van Mechelen, P.; Vazdik, Y.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wegener, D.; Wichmann, K.; Wing, M.; Wolf, G.; Wünsch, E.; Yamada, S.; Yamazaki, Y.; Žáček, J.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhang, Z.; Zhautykov, B. O.; Zhmak, N.; Žlebčík, R.; Zohrabyan, H.; Zomer, F.; Zotkin, D. S.

    2015-12-01

    A combination is presented of all inclusive deep inelastic cross sections previously published by the H1 and ZEUS collaborations at HERA for neutral and charged current e^{± }p scattering for zero beam polarisation. The data were taken at proton beam energies of 920, 820, 575 and 460 GeV and an electron beam energy of 27.5 GeV. The data correspond to an integrated luminosity of about 1 fb^{-1} and span six orders of magnitude in negative four-momentum-transfer squared, Q^2, and Bjorken x. The correlations of the systematic uncertainties were evaluated and taken into account for the combination. The combined cross sections were input to QCD analyses at leading order, next-to-leading order and at next-to-next-to-leading order, providing a new set of parton distribution functions, called HERAPDF2.0. In addition to the experimental uncertainties, model and parameterisation uncertainties were assessed for these parton distribution functions. Variants of HERAPDF2.0 with an alternative gluon parameterisation, HERAPDF2.0AG, and using fixed-flavour-number schemes, HERAPDF2.0FF, are presented. The analysis was extended by including HERA data on charm and jet production, resulting in the variant HERAPDF2.0Jets. The inclusion of jet-production cross sections made a simultaneous determination of these parton distributions and the strong coupling constant possible, resulting in α _s(M_Z^2)=0.1183 ± 0.0009 (exp) ± 0.0005(model/parameterisation) ± 0.0012(hadronisation) ^{+0.0037}_{-0.0030}(scale). An extraction of xF_3^{γ Z} and results on electroweak unification and scaling violations are also presented.

  17. Deep inelastic cross-section measurements at large y with the ZEUS detector at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A. N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E. G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R. K.; Devenish, R. C. E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L. A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kotański, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J. F.; Mergelmeyer, S.; Mohamad Idris, F.; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R. J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlański, W.; Perrey, H.; Pokrovskiy, N. S.; Proskuryakov, A. S.; Przybycień, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schneekloth, U.; Schörner-Sadenius, T.; Schwartz, J.; Shcheglova, L. M.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zhmak, N.; Zotkin, D. S.; ZEUS Collaboration

    2014-10-01

    The reduced cross sections for e+p deep inelastic scattering have been measured with the ZEUS detector at HERA at three different center-of-mass energies, 318, 251 and 225 GeV. The cross sections, measured double differentially in Bjorken x and the virtuality, Q2, were obtained in the region 0.13≤y ≤0.75, where y denotes the inelasticity and 5≤Q2≤110 GeV2. The proton structure functions F2 and FL were extracted from the measured cross sections.

  18. Limits on the effective quark radius from inclusive ep scattering at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Antonelli, S.; Aushev, V.; Behnke, O.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Boos, E. G.; Brock, I.; Brook, N. H.; Brugnera, R.; Bruni, A.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Dementiev, R. K.; Devenish, R. C. E.; Dusini, S.; Foster, B.; Gach, G.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Golubkov, Yu. A.; Grzelak, G.; Guzik, M.; Gwenlan, C.; Hain, W.; Hlushchenko, O.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Januschek, F.; Jomhari, N. Z.; Kadenko, I.; Kananov, S.; Karshon, U.; Kaur, P.; Kisielewska, D.; Klanner, R.; Klein, U.; Korzhavina, I. A.; Kotański, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Krupa, B.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Makarenko, I.; Malka, J.; Mastroberardino, A.; Mohamad Idris, F.; Mohammad Nasir, N.; Myronenko, V.; Nagano, K.; Nobe, T.; Nowak, R. J.; Onishchuk, Yu.; Paul, E.; Perlański, W.; Pokrovskiy, N. S.; Polini, A.; Przybycień, M.; Roloff, P.; Ruspa, M.; Saxon, D. H.; Schioppa, M.; Schneekloth, U.; Schörner-Sadenius, T.; Shcheglova, L. M.; Shevchenko, R.; Shkola, O.; Shyrma, Yu.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Solano, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stopa, P.; Sukhonos, D.; Sztuk-Dambietz, J.; Tassi, E.; Tokushuku, K.; Tomaszewska, J.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zotkin, D. S.

    2016-06-01

    The high-precision HERA data allows searches up to TeV scales for beyond the Standard Model contributions to electron-quark scattering. Combined measurements of the inclusive deep inelastic cross sections in neutral and charged current ep scattering corresponding to a luminosity of around 1 fb-1 have been used in this analysis. A new approach to the beyond the Standard Model analysis of the inclusive ep data is presented; simultaneous fits of parton distribution functions together with contributions of "new physics" processes were performed. Results are presented considering a finite radius of quarks within the quark form-factor model. The resulting 95% C.L. upper limit on the effective quark radius is 0.43 ṡ10-16 cm.

  19. Measurement of “pretzelosity” asymmetry of charged pion production in semi-inclusive deep inelastic scattering on a polarized He3 target

    SciTech Connect

    Zhang, Y.; Qian, X.; Allada, K.; Dutta, C.; Huang, J.; Katich, J.; Wang, Y.; Aniol, K.; Annand, J. R. M.; Averett, T.; Benmokhtar, F.; Bertozzi, W.; Bradshaw, P. C.; Bosted, P.; Camsonne, A.; Canan, M.; Cates, G. D.; Chen, C.; Chen, J. -P.; Chen, W.; Chirapatpimol, K.; Chudakov, E.; Cisbani, E.; Cornejo, J. C.; Cusanno, F.; Dalton, M. M.; Deconinck, W.; de Jager, C. W.; De Leo, R.; Deng, X.; Deur, A.; Ding, H.; Dolph, P. A. M.; Dutta, D.; El Fassi, L.; Frullani, S.; Gao, H.; Garibaldi, F.; Gaskell, D.; Gilad, S.; Gilman, R.; Glamazdin, O.; Golge, S.; Guo, L.; Hamilton, D.; Hansen, O.; Higinbotham, D. W.; Holmstrom, T.; Huang, M.; Ibrahim, H. F.; Iodice, M.; Jiang, X.; Jin, G.; Jones, M. K.; Kelleher, A.; Kim, W.; Kolarkar, A.; Korsch, W.; LeRose, J. J.; Li, X.; Li, Y.; Lindgren, R.; Liyanage, N.; Long, E.; Lu, H. -J.; Margaziotis, D. J.; Markowitz, P.; Marrone, S.; McNulty, D.; Meziani, Z. -E.; Michaels, R.; Moffit, B.; Muñoz Camacho, C.; Nanda, S.; Narayan, A.; Nelyubin, V.; Norum, B.; Oh, Y.; Osipenko, M.; Parno, D.; Peng, J. C.; Phillips, S. K.; Posik, M.; Puckett, A. J. R.; Qiang, Y.; Rakhman, A.; Ransome, R. D.; Riordan, S.; Saha, A.; Sawatzky, B.; Schulte, E.; Shahinyan, A.; Shabestari, M. H.; Širca, S.; Stepanyan, S.; Subedi, R.; Sulkosky, V.; Tang, L. -G.; Tobias, W. A.; Urciuoli, G. M.; Vilardi, I.; Wang, K.; Wojtsekhowski, B.; Yan, X.; Yao, H.; Ye, Y.; Ye, Z.; Yuan, L.; Zhan, X.; Zhang, Y. -W.; Zhao, B.; Zheng, X.; Zhu, L.; Zhu, X.; Zong, X.

    2014-11-24

    An experiment to measure single-spin asymmetries in semi-inclusive production of charged pions in deep-inelastic scattering on a transversely polarized ³He target was performed at Jefferson Lab in the kinematic region of 0.16 < x < 0.35 and 1.4 < Q² < 2.7 GeV². Our results show that both π± on 3He and on neutron pretzelosity asymmetries are consistent with zero within experimental uncertainties.

  20. Single spin asymmetries in charged kaon production from semi-inclusive deep inelastic scattering on a transversely polarized He3 target

    SciTech Connect

    Zhao, Y. X.; Wang, Y.; Allada, K.; Aniol, K.; Annand, J. R.M.; Averett, T.; Benmokhtar, F.; Bertozzi, W.; Bradshaw, P. C.; Bosted, P.; Camsonne, A.; Canan, M.; Cates, G. D.; Chen, C.; Chen, J. -P.; Chen, W.; Chirapatpimol, K.; Chudakov, E.; Cisbani, E.; Cornejo, J. C.; Cusanno, F.; Dalton, M. M.; Deconinck, W.; de Jager, C. W.; De Leo, R.; Deng, X.; Deur, A.; Ding, H.; Dolph, P. A. M.; Dutta, C.; Dutta, D.; El Fassi, L.; Frullani, S.; Gao, H.; Garibaldi, F.; Gaskell, D.; Gilad, S.; Gilman, R.; Glamazdin, O.; Golge, S.; Guo, L.; Hamilton, D.; Hansen, O.; Higinbotham, D. W.; Holmstrom, T.; Huang, J.; Huang, M.; Ibrahim, H. F.; Iodice, M.; Jiang, X.; Jin, G.; Jones, M. K.; Katich, J.; Kelleher, A.; Kim, W.; Kolarkar, A.; Korsch, W.; LeRose, J. J.; Li, X.; Li, Y.; Lindgren, R.; Liyanage, N.; Long, E.; Lu, H. -J.; Margaziotis, D. J.; Markowitz, P.; Marrone, S.; McNulty, D.; Meziani, Z. -E.; Michaels, R.; Moffit, B.; Muñoz Camacho, C.; Nanda, S.; Narayan, A.; Nelyubin, V.; Norum, B.; Oh, Y.; Osipenko, M.; Parno, D.; Peng, J. -C.; Phillips, S. K.; Posik, M.; Puckett, A. J. R.; Qian, X.; Qiang, Y.; Rakhman, A.; Ransome, R.; Riordan, S.; Saha, A.; Sawatzky, B.; Schulte, E.; Shahinyan, A.; Shabestari, M. H.; Širca, S.; Stepanyan, S.; Subedi, R.; Sulkosky, V.; Tang, L. -G.; Tobias, A.; Urciuoli, G. M.; Vilardi, I.; Wang, K.; Wojtsekhowski, B.; Yan, X.; Yao, H.; Ye, Y.; Ye, Z.; Yuan, L.; Zhan, X.; Zhang, Y.; Zhang, Y. -W.; Zhao, B.; Zheng, X.; Zhu, L.; Zhu, X.; Zong, X.

    2014-11-03

    We report the first measurement of target single spin asymmetries of charged kaons produced in semi-inclusive deep inelastic scattering of electrons off a transversely polarized 3He target. Both the Collins and Sivers moments, which are related to the nucleon transversity and Sivers distributions, respectively, are extracted over the kinematic range of 0.1 < xbj<0.4 for K+ and K production. While the Collins and Sivers moments for K+ are consistent with zero within the experimental uncertainties, both moments for K favor negative values. The Sivers moments are compared to the theoretical prediction from a phenomenological fit to the world data. While the K+ Sivers moments are consistent with the prediction, the K results differ from the prediction at the 2-sigma level.

  1. Beam-Target Double-Spin Asymmetry ALT in Charged Pion Production from Deep Inelastic Scattering on a Transversely Polarized He3 Target at 1.4

    DOE PAGES

    Huang, J.; Allada, K.; Dutta, C.; ...

    2012-01-01

    We report the first measurement of the double-spin asymmetry ALT for charged pion electroproduction in semi-inclusive deep inelastic electron scattering on a transversely polarized 3He target. The kinematics focused on the valence quark region, 0.16 < x < 0.35 with 1.4 < Q2 < 2.7 GeV2. The corresponding neutron ALT asymmetries were extracted from the measured 3He asymmetries and proton/3He cross section ratios using the effective polarization approximation. These new data probe the transverse momentum dependent parton distribution function g1Tq and therefore provide access to quark spin-orbit correlations. Our results indicate a positive azimuthal asymmetry for π- production on 3Hemore » and the neutron, while our π+ asymmetries are consistent with zero.« less

  2. Beam-target double-spin asymmetry A{LT} in charged pion production from deep inelastic scattering on a transversely polarized {3}He target at 1.4

    PubMed

    Huang, J; Allada, K; Dutta, C; Katich, J; Qian, X; Wang, Y; Zhang, Y; Aniol, K; Annand, J R M; Averett, T; Benmokhtar, F; Bertozzi, W; Bradshaw, P C; Bosted, P; Camsonne, A; Canan, M; Cates, G D; Chen, C; Chen, J-P; Chen, W; Chirapatpimol, K; Chudakov, E; Cisbani, E; Cornejo, J C; Cusanno, F; Dalton, M M; Deconinck, W; de Jager, C W; De Leo, R; Deng, X; Deur, A; Ding, H; Dolph, P A M; Dutta, D; El Fassi, L; Frullani, S; Gao, H; Garibaldi, F; Gaskell, D; Gilad, S; Gilman, R; Glamazdin, O; Golge, S; Guo, L; Hamilton, D; Hansen, O; Higinbotham, D W; Holmstrom, T; Huang, M; Ibrahim, H F; Iodice, M; Jiang, X; Jin, G; Jones, M K; Kelleher, A; Kim, W; Kolarkar, A; Korsch, W; Lerose, J J; Li, X; Li, Y; Lindgren, R; Liyanage, N; Long, E; Lu, H-J; Margaziotis, D J; Markowitz, P; Marrone, S; McNulty, D; Meziani, Z-E; Michaels, R; Moffit, B; Muñoz Camacho, C; Nanda, S; Narayan, A; Nelyubin, V; Norum, B; Oh, Y; Osipenko, M; Parno, D; Peng, J C; Phillips, S K; Posik, M; Puckett, A J R; Qiang, Y; Rakhman, A; Ransome, R D; Riordan, S; Saha, A; Sawatzky, B; Schulte, E; Shahinyan, A; Shabestari, M H; Sirca, S; Stepanyan, S; Subedi, R; Sulkosky, V; Tang, L-G; Tobias, A; Urciuoli, G M; Vilardi, I; Wang, K; Wojtsekhowski, B; Yan, X; Yao, H; Ye, Y; Ye, Z; Yuan, L; Zhan, X; Zhang, Y-W; Zhao, B; Zheng, X; Zhu, L; Zhu, X; Zong, X

    2012-02-03

    We report the first measurement of the double-spin asymmetry A{LT} for charged pion electroproduction in semi-inclusive deep-inelastic electron scattering on a transversely polarized {3}He target. The kinematics focused on the valence quark region, 0.16

  3. First measurement of unpolarized semi-inclusive deep-inelastic scattering cross sections from a He3 target [First measurement of unpolarized SIDIS cross section from a 3He target

    DOE PAGES

    Yan, X.; Allada, K.; Aniol, K.; ...

    2017-03-24

    Here, the unpolarized semi-inclusive deep-inelastic scattering (SIDIS) differential cross sections in 3He(e,e'π±)X have been measured for the first time in Jefferson Lab experiment E06-010 with a 5.9 GeV e– beam on a 3He gas target. The experiment focuses on the valence quark region, covering a kinematic range 0.12 < xbj < 0.45,1 < Q2 < 4(GeV/c)2,0.45 < zh < 0.65, and 0.05 < Pt < 0.55GeV/c. The extracted SIDIS differential cross sections of π± production are compared with existing phenomenological models while the 3He nucleus approximated as two protons and one neutron in a plane-wave picture, in multidimensional bins. Withinmore » the experimental uncertainties, the azimuthal modulations of the cross sections are found to be consistent with zero.« less

  4. QCD studies in ep collisions

    SciTech Connect

    Smith, W.H.

    1997-06-01

    These lectures describe QCD physics studies over the period 1992--1996 from data taken with collisions of 27 GeV electrons and positrons with 820 GeV protons at the HERA collider at DESY by the two general-purpose detectors H1 and ZEUS. The focus of these lectures is on structure functions and jet production in deep inelastic scattering, photoproduction, and diffraction. The topics covered start with a general introduction to HERA and ep scattering. Structure functions are discussed. This includes the parton model, scaling violation, and the extraction of F{sub 2}, which is used to determine the gluon momentum distribution. Both low and high Q{sup 2} regimes are discussed. The low Q{sup 2} transition from perturbative QCD to soft hadronic physics is examined. Jet production in deep inelastic scattering to measure {alpha}{sub s}, and in photoproduction to study resolved and direct photoproduction, is also presented. This is followed by a discussion of diffraction that begins with a general introduction to diffraction in hadronic collisions and its relation to ep collisions, and moves on to deep inelastic scattering, where the structure of diffractive exchange is studied, and in photoproduction, where dijet production provides insights into the structure of the Pomeron. 95 refs., 39 figs.

  5. A precise measurement of the polarization of a 200 GeV muon beam in a polarized deep inelastic scattering experiment at CERN

    NASA Astrophysics Data System (ADS)

    Eichblatt, Stephen Lynn

    1997-09-01

    The Spin Muon Collaboration (SMC) measures the spin dependent structure function g1 of the proton and nentron by measuring the scattering asymmetry of polarized 200 GeV muons off polarized protons and deuterons. The structure functions enable tests of theoretical sum rules, and a measurement of the spin contribution of the quarks to the nucleon. The uncertainty of the muon beam polarization was a major source of error in preliminary measurements of proton structure functions. A muon polarimeter measuring the shape of the Michel spectrum of positrons from muon decay was built. In this polarimeter muons enter and are allowed to decay (μ+ /to e+νe/barνμ) in a 35 meter length. The shape of the momentum spectrum of electrons is sensitive to the muon polarization. The decay positrons are momentum-analyzed and the measured spectrum is fit to the Michel formula to determine the polarization. A data sample with a μsp- beam was used to estimate the effects of background events in the spectrum. Careful analysis of the polarimeter data determined the polarization to within 3%. The muon polarization was found to be stable in time and to vary with muon momentum. This variation will be included in the structure function analysis. A second polarimeter measuring the scattering asymmetry of polarized muons off polarized electrons obtained consistent results. The two independent polarization measurements were combined to give a polarization of -0.778 ± 0.019 at 186.9 GeV. With the improved structure function measurements, the Bjorken sum rule was tested and confirmed. Assuming that the gluons are unpolarized, the contribution of the quarks to the nucleon spin was estimated to be 20%, and the strange quark sea negatively polarized.

  6. Single-spin beam asymmetry in semi-exclusive deep-inelastic electroproduction

    SciTech Connect

    Andrei Afanasev; C. E. Carlson

    2003-05-01

    Recent measurements from Jefferson Lab show significant beam single spin asymmetries in deep inelastic scattering. The asymmetry is due to interference of longitudinal and transverse photoabsorption amplitudes which have different phases induced by the final-state interaction between the struck quark and the target spectators. We developed a dynamical model for a single-spin beam asymmetry in deep-inelastic scattering. Our results are consistent with the experimentally observed magnitude of this effect. We conclude that similar mechanisms involving quark orbital angular momentum ('Sivers effect') are responsible for both target and beam single-spin asymmetries.

  7. Rapidity gaps in deep inelastic scattering

    SciTech Connect

    Bjorken, J.D. |

    1995-12-31

    A simple semiquantitative picture of diffractive electroproduction is described. Although the diffractive component of F{sub 2} is approximately independent of Q{sup 2} and W{sup 2}, this mechanism is ``soft,`` i.e. it depends upon large-distance physics and is not readily describable within perturbative QCD.

  8. Phenomenology of deep-inelastic processes

    SciTech Connect

    Moretto, L.G.

    1983-03-01

    The field of heavy-ion deep-inelastic reactions is reviewed with particular attention to the experimental picture. The most important degrees of freedom involved in the process are identified and illustrated with relevant experiments. Energy dissipation and mass transfer are discussed in terms of particles and/or phonons exchanged in the process. The equilibration of the fragment neutron-to-proton ratios is inspected for evidence of giant isovector resonances. The angular momentum effects are observed in the fragment angular distributions and the angular momentum transfer is inferred from the magnitude and alignment of the fragments spins. The possible sources of light particles accompanying the deep-inelastic reactions are discussed. The use of the sequentially emitted particles as angular momentum probes is illustrated. The significance and uses of a thermalized component emitted by the dinucleus is reviewed. The possible presence of Fermi jets in the prompt component is shown to be critical to the justification of the one-body theories.

  9. Statistical properties of deep inelastic reactions

    SciTech Connect

    Moretto, L.G.

    1983-08-01

    The multifaceted aspects of deep-inelastic heavy-ion collisions are discussed in terms of the statistical equilibrium limit. It is shown that a conditional statistical equilibrium, where a number of degrees of freedom are thermalized while others are still relaxing, prevails in most of these reactions. The individual degrees of freedom that have been explored experimentally are considered in their statistical equilibrium limit, and the extent to which they appear to be thermalized is discussed. The interaction between degrees of freedom on their way towards equilibrium is shown to create complex feedback phenomena that may lead to self-regulation. A possible example of self-regulation is shown for the process of energy partition between fragments promoted by particle exchange. 35 references.

  10. Interplay of threshold resummation and hadron mass corrections in deep inelastic processes

    SciTech Connect

    Accardi, Alberto; Anderle, Daniele P.; Ringer, Felix

    2015-02-01

    We discuss hadron mass corrections and threshold resummation for deep-inelastic scattering lN-->l'X and semi-inclusive annihilation e+e- → hX processes, and provide a prescription how to consistently combine these two corrections respecting all kinematic thresholds. We find an interesting interplay between threshold resummation and target mass corrections for deep-inelastic scattering at large values of Bjorken xB. In semi-inclusive annihilation, on the contrary, the two considered corrections are relevant in different kinematic regions and do not affect each other. A detailed analysis is nonetheless of interest in the light of recent high precision data from BaBar and Belle on pion and kaon production, with which we compare our calculations. For both deep inelastic scattering and single inclusive annihilation, the size of the combined corrections compared to the precision of world data is shown to be large. Therefore, we conclude that these theoretical corrections are relevant for global QCD fits in order to extract precise parton distributions at large Bjorken xB, and fragmentation functions over the whole kinematic range.

  11. Interplay of threshold resummation and hadron mass corrections in deep inelastic processes

    DOE PAGES

    Accardi, Alberto; Anderle, Daniele P.; Ringer, Felix

    2015-02-01

    We discuss hadron mass corrections and threshold resummation for deep-inelastic scattering lN-->l'X and semi-inclusive annihilation e+e- → hX processes, and provide a prescription how to consistently combine these two corrections respecting all kinematic thresholds. We find an interesting interplay between threshold resummation and target mass corrections for deep-inelastic scattering at large values of Bjorken xB. In semi-inclusive annihilation, on the contrary, the two considered corrections are relevant in different kinematic regions and do not affect each other. A detailed analysis is nonetheless of interest in the light of recent high precision data from BaBar and Belle on pion and kaonmore » production, with which we compare our calculations. For both deep inelastic scattering and single inclusive annihilation, the size of the combined corrections compared to the precision of world data is shown to be large. Therefore, we conclude that these theoretical corrections are relevant for global QCD fits in order to extract precise parton distributions at large Bjorken xB, and fragmentation functions over the whole kinematic range.« less

  12. Angular correlations in three-jet events in ep collisions at HERA

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Aushev, V.; Aushev, Y.; Bachynska, O.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Bartosik, N.; Bartsch, D.; Basile, M.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Bertolin, A.; Bhadra, S.; Bindi, M.; Blohm, C.; Bokhonov, V.; Bołd, T.; Bondarenko, K.; Boos, E. G.; Borras, K.; Boscherini, D.; Bot, D.; Brock, I.; Brownson, E.; Brugnera, R.; Brümmer, N.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bussey, P. J.; Bylsma, B.; Caldwell, A.; Capua, M.; Carlin, R.; Catterall, C. D.; Chekanov, S.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; D'Agostini, G.; Corso, F. Dal; del Peso, J.; Dementiev, R. K.; De Pasquale, S.; Derrick, M.; Devenish, R. C. E.; Dobur, D.; Dolgoshein, B. A.; Dolinska, G.; Doyle, A. T.; Drugakov, V.; Durkin, L. S.; Dusini, S.; Eisenberg, Y.; Ermolov, P. F.; Eskreys, A.; Fang, S.; Fazio, S.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Forrest, M.; Foster, B.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gialas, I.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Gogota, O.; Golubkov, Yu. A.; Göttlicher, P.; Grabowska-Bołd, I.; Grebenyuk, J.; Gregor, I.; Grigorescu, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Gwenlan, C.; Haas, T.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Hilger, E.; Hochman, D.; Hori, R.; Horton, K.; Hüttmann, A.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Jakob, H.-P.; Januschek, F.; Jimenez, M.; Jones, T. W.; Jüngst, M.; Kadenko, I.; Kahle, B.; Kananov, S.; Kanno, T.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, M.; Kaur, P.; Keramidas, A.; Khein, L. A.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, U.; Koffeman, E.; Kooijman, P.; Korol, Ie.; Korzhavina, I. A.; Kotański, A.; Kötz, U.; Kowalski, H.; Kuprash, O.; Kuze, M.; Lee, A.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Ling, T. Y.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Magill, S.; Makarenko, I.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Martin, J. F.; Mastroberardino, A.; Mattingly, M. C. K.; Melzer-Pellmann, I.-A.; Mergelmeyer, S.; Miglioranzi, S.; Mohamad Idris, F.; Monaco, V.; Montanari, A.; Morris, J. D.; Mujkic, K.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Nigro, A.; Ning, Y.; Nobe, T.; Noor, U.; Notz, D.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Oliver, K.; Olkiewicz, K.; Onishchuk, Yu.; Papageorgiu, K.; Parenti, A.; Paul, E.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perlański, W.; Perrey, H.; Piotrzkowski, K.; Pluciński, P.; Pokrovskiy, N. S.; Polini, A.; Proskuryakov, A. S.; Przybycień, M.; Raval, A.; Reeder, D. D.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Robertson, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Sacchi, R.; Salii, A.; Samson, U.; Sartorelli, G.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schneekloth, U.; Schönberg, V.; Schörner-Sadenius, T.; Schwartz, J.; Sciulli, F.; Shcheglova, L. M.; Shehzadi, R.; Shimizu, S.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Smith, W. H.; Sola, V.; Solano, A.; Son, D.; Sosnovtsev, V.; Spiridonov, A.; Stadie, H.; Stanco, L.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stopa, P.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tapper, A. D.; Tassi, E.; Terrón, J.; Theedt, T.; Tiecke, H.; Tokushuku, K.; Tomalak, O.; Tomaszewska, J.; Tsurugai, T.; Turcato, M.; Tymieniecka, T.; Vázquez, M.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Volynets, O.; Walczak, R.; Wan Abdullah, W. A. T.; Whitmore, J. J.; Wiggers, L.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Yagües-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zeuner, W.; Zhautykov, B. O.; Zhmak, N.; Zhou, C.; Zichichi, A.; Zolkapli, Z.; Zolko, M.; Zotkin, D. S.

    2012-03-01

    Three-jet production in deep inelastic ep scattering and photoproduction was investigated with the ZEUS detector at HERA using an integrated luminosity of up to 127pb-1. Measurements of differential cross sections are presented as functions of angular correlations between the three jets in the final state and the proton-beam direction. These correlations provide a stringent test of perturbative QCD and show sensitivity to the contributions from different color configurations. Fixed-order perturbative calculations assuming the values of the color factors CF, CA, and TF as derived from a variety of gauge groups were compared to the measurements to study the underlying gauge group symmetry. The measured angular correlations in the deep inelastic ep scattering and photoproduction regimes are consistent with the admixture of color configurations as predicted by SU(3) and disfavour other symmetry groups, such as SU(N) in the limit of large N.

  13. Recent progress in electron scattering at SLAC

    SciTech Connect

    Arnold, R.G.

    1984-09-01

    A new experiment on ep elastic scattering at large momentum transfer, Experiment E136, has recently completed data taking. A new measurement of deep inelastic electron scattering from nuclear targets, Experiment E139, has been completed and preliminary results are available. A new program of experiments has begun, called Nuclear Physics at SLAC (NPAS), that will use a new injector on the SLAC linac to provide high intensity beams in the energy range from 0.5 to 6 GeV.

  14. Polarized e-p elastic scattering in the collider frame

    SciTech Connect

    Sofiatti, C.; Donnelly, T. W.

    2011-07-15

    Double polarization elastic e-vector-p-vector cross sections and asymmetries are considered in collider kinematics. Covariant expressions are derived for the general situation involving crossed beams; these are checked against the well-known results obtained when the proton is at rest. Results are given using modern models for the proton electromagnetic form factors for kinematics of interest in e-p colliders such as the Electron-Ion Collider facility which is in its planning stage. In context, parity-violating elastic e-vector-p scattering is compared and contrasted with these double-polarization (parity-conserving) results.

  15. Deep Inelastic Transfer Reactions - A New Way to Exotic Nuclei?

    NASA Astrophysics Data System (ADS)

    Heinz, Sophie; Beliuskina, Olga

    2014-05-01

    We studied deep inelastic multinucleon transfer reactions in collisions of 64Ni+207Pb and 48Ca+238U at energies around the Coulomb barrier. The experiments were performed at the velocity filter SHIP at GSI Darmstadt. One of the goals was to investigate if deep inelastic transfer is superior to fragmentation reactions for producing neutron-rich isotopes in the astrophysically interesting region of nuclei along the magic neutron number N = 126. With both collision systems, rather neutron-rich transfer products were populated, some of them reaching out to the limits of the present chart of nuclides. New isotopes could not be identified. A comparison of the measured transfer cross-sections and yields with those from fragmentation reactions allowed for interesting conclusions.

  16. Deep inelastic separated response functions from 40Ca and 48Ca

    NASA Astrophysics Data System (ADS)

    Deady, M.; Williamson, C. F.; Zimmerman, P. D.; Altemus, R.; Whitney, R. R.

    1986-06-01

    Deep inelastic scattering cross sections have been measured for 40Ca and 48Ca at electron energies between 100 and 375 MeV at scattering angles of 90° and 140°. Longitudinal and transverse response functions at three-momentum transfers between 250 and 410 MeV/c have been extracted using a Rosenbluth separation. The response functions are compared to calculations modeling the nucleus as a noninteracting relativistic Fermi gas. The model is found to agree with the observed transverse response function in the region of expected quasi-free nucleon knockout, but the model overestimates the observed longitudinal response. Comparisons of the response functions of the two isotopes are made, and differences between 40Ca and 48Ca are seen.

  17. Transition from quasi-elastic to deep-inelastic reactions

    SciTech Connect

    Rehm, K.E.

    1986-01-01

    Heavy ion induced transfer reactions are usually considered to fall into two categories. Quasi-elastic processes, on one hand, are characterized by small energy transfers, with one-nucleon transfer reactions being a typical example. These processes are dominant for grazing collisions, and are generally described within simple one-step DWBA calculations. Deep inelastic reactions, on the other hand, occur for more central collisions where the interaction time is longer and subsequently more energy and particles can be exchanged. Quasi-elastic collisions dominate transfer reactions induced by light heavy ions (e.g., /sup 16/O) at energies not too high above the barrier, while deep inelastic collisions are observed mainly in reactions induced by heavier projectiles (Kr, Xe). In this contribution, we discuss the transition between these two processes for the system /sup 48/Ti + /sup 208/Pb. /sup 48/Ti is located between light (/sup 16/O) and heavy (Kr) projectiles and should be well suited for a study of the interrelation between quasi- and deep-inelastic reactions. The experiments were performed with a 300 MeV /sup 48/Ti beam obtained from the Argonne National Laboratory superconducting linac. The outgoing particles were momentum analyzed in a split pole magnetic spectrograph and detected in the focal plane by a position sensitive ionization chamber. The specific energy loss, the magnetic rigidity and the total energy of the outgoing particles were measured enabling mass and Z-identification. The energy resolution was about 3 MeV, determined by the thickness of the /sup 208/Pb target, and thus excluded study of transfer reactions to discrete final states. Angular distributions were measured in the range theta/sub lab/ = 20/sup 0/ to 80/sup 0/ in steps of 5/sup 0/. 8 refs.

  18. Measurement of Single and Double Spin Asymmetries in Deep Inelastic Pion Electroproduction with a Longitudinally Polarized Target

    SciTech Connect

    Avakian, H; Bosted, P; Elouadrhiri, L; Adhikari, K P; Aghasyan, M; Amaryan, M; Anghinolfi, M; Baghdasaryan, H; Ball, J; Battaglieri, M; Bedlinskiy, I; Biselli, A S; Branford, D; Briscoe, W J; Brooks, W; Carman, D S; Casey, L; Cole, P L; Collins, P; Crabb, D; Crede, V; D'Angelo, A; Daniel, A; Dashyan, N; DeVita, R; DeSanctis, E; Deur, A; Dey, B; Dhamija, S; Dickson, R; Djalali, C; Dodge, G; Doughty, D; Dupre, R; El Alaoui, A; Eugenio, P; Fegan, S; Fersch, M; Guler, N; Guo, L; Hafidi, K; Hakobyan, H; Hanretty, C; Hassall, N; Heddle, D; Hicks, K; Holtrop, M; Ilieva, Y; Ireland, D G; Isupov, E L; Jawalkar, S S; Jo, H S; Joo, K; Keller, D; Khandaker, M; Khetarpal,; Kim, W; Klein, A; Klein, F J; Konczykowski, P; Kubarovsky, V; Kuhn, S E; Kuleshov, S V; Kuznetsov, V; Livingston, K; Lu, H Y; Markov, N; Mayer, M; McAndrew, J; McCracken, M E; McKInnon, B; Meyer, C A; Mineeva, T; Mirazita, M; Mokeev, V; Moreno, B; Moriya, K; Morrison, B; Moutarde, H; Munevar, E; Nadel-Turonski, P; Nasseripour, R; Niccolai, S; Niculescu, G; Niculescu, I; Niroula, M R; Osipenko, M; Ostrovidov, A I; Paremuzyan, R; Park, K; Park, S; Pasyuk, E; Anefalos Pereira, S; Perrin, Y; Pisano, S; Pogorelko, O; Price, J W; Procureur, S; Prok, Protopopescu; Raue, B A; Ricco, G; Ripani, M; Rosner, G; Rossi, P; Sabatie, F; Saini, M S; Salamanca, J; Salgado, C; Schumacher, R A; Seder, E; Seraydaryan, H; Sharabian, Y G; Sober, D I; Sokhan, D; Stapanyan, S S; Stepanyan, S; Stoler, P; Strauch, S; Suleiman, R; Taiuti, M; Tedeschi, D J; Tkachenko, S; Ungaro, M; Vernarsky, B; Vineyard, M F; Voutier, E; Watts, D P; Weinstein, L B; Weygand, D P; Wood, M H; Zhang, J; Zhao, B; Zhao, Z W

    2010-12-01

    We report the first measurement of the transverse momentum dependence of double spin asymmetries in semi-inclusive production of pions in deep inelastic scattering off the longitudinally polarized proton. Data have been obtained using a polarized electron beam of 5.7 GeV with the CLAS detector at the Thomas Jefferson National Accelerator Facility (JLab). A significant non-zero $\\sin2\\phi$ single spin asymmetry was also observed for the first time indicating strong spin-orbit correlations for transversely polarized quarks in the longitudinally polarized proton. The azimuthal modulations of single spin asymmetries have been measured over a wide kinematic range.

  19. Absolute Beam Energy Measurement using Elastic ep Scattering at Thomas Jefferson National Accelerator Facility

    NASA Astrophysics Data System (ADS)

    Deur, Alexandre

    1999-10-01

    The Jefferson Lab beam energy measurement in Hall A using the elastic ep scattering will be described. This new, non-magnetic, energy measurement method allows a ( triangle E/E=10-4 ) precision. First-order corrections are canceled by the measurements of the electron and proton scattering angles for two symmetric kinematics. The measurement principle will be presented as well as the device and measurement results. Comparison with independent magnetic energy measurements of the same accuracy will be shown. This project is the result of a collaboration between the LPC: université Blaise Pascal/in2p3), Saclay and Jefferson Lab.

  20. The Proton Coulomb Form Factor from Polarized Inclusive e-p Scattering

    SciTech Connect

    Harris, Christopher Matthew

    2001-05-01

    The proton form factors provide information on the fundamental properties of the proton and provide a test for models based on QCD. In 1998 at Jefferson Lab (JLAB) in Newport News, VA, experiment E93026 measured the inclusive e-p scattering cross section from a polarized ammonia (15NH3) target at a four momentum transfer squared of Q2 = 0.5 (GeV/c)2. Longitudinally polarized electrons were scattered from the polarized target and the scattered electron was detected. Data has been analyzed to obtain the asymmetry from elastically scattered electrons from hydrogen in 15NH3. The asymmetry, Ap, has been used to determine the proton elastic form factor GEp. The result is consistent with the dipole model and data from previous experiments. However, due to the choice of kinematics, the uncertainty in the measurement is large.

  1. Measurement of the structure function of the nearly free neutron using spectator tagging in inelastic 2H(e ,e'ps )X scattering with CLAS

    NASA Astrophysics Data System (ADS)

    Tkachenko, S.; Baillie, N.; Kuhn, S. E.; Zhang, J.; Arrington, J.; Bosted, P.; Bültmann, S.; Christy, M. E.; Fenker, H.; Griffioen, K. A.; Kalantarians, N.; Keppel, C. E.; Melnitchouk, W.; Tvaskis, V.; Adhikari, K. P.; Aghasyan, M.; Amaryan, M. J.; Anefalos Pereira, S.; Avakian, H.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Bedlinskiy, I.; Biselli, A. S.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Cole, P. L.; Contalbrigo, M.; Cortes, O.; Crede, V.; D'Angelo, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Deur, A.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dupre, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fleming, J. A.; Garillon, B.; Gevorgyan, N.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Golovatch, E.; Gothe, R. W.; Guidal, M.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Harrison, N.; Hattawy, M.; Hicks, K.; Ho, D.; Holtrop, M.; Hyde, C. E.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Jo, H. S.; Keller, D.; Khandaker, M.; Kim, A.; Kim, W.; King, P. M.; Klein, A.; Klein, F. J.; Koirala, S.; Kubarovsky, V.; Kuleshov, S. V.; Lenisa, P.; Lewis, S.; Livingston, K.; Lu, H.; MacCormick, M.; MacGregor, I. J. D.; Markov, N.; Mayer, M.; McKinnon, B.; Mineeva, T.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Moutarde, H.; Munoz Camacho, C.; Nadel-Turonski, P.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Pappalardo, L. L.; Paremuzyan, R.; Park, K.; Pasyuk, E.; Phillips, J. J.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Protopopescu, D.; Puckett, A. J. R.; Rimal, D.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Schott, D.; Schumacher, R. A.; Seder, E.; Senderovich, I.; Sharabian, Y. G.; Simonyan, A.; Smith, G. D.; Sober, D. I.; Sokhan, D.; Stepanyan, S.; Stepanyan, S. S.; Strauch, S.; Tang, W.; Ungaro, M.; Vlassov, A. V.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zana, L.; Zonta, I.; CLAS Collaboration

    2014-04-01

    Background: Much less is known about neutron structure than that of the proton due to the absence of free neutron targets. Neutron information is usually extracted from data on nuclear targets such as deuterium, requiring corrections for nuclear binding and nucleon off-shell effects. These corrections are model dependent and have significant uncertainties, especially for large values of the Bjorken scaling variable x . As a consequence, the same data can lead to different conclusions, for example, about the behavior of the d quark distribution in the proton at large x . Purpose: The Barely Off-shell Nucleon Structure experiment at Jefferson Lab measured the inelastic electron-deuteron scattering cross section, tagging spectator protons in coincidence with the scattered electrons. This method reduces nuclear binding uncertainties significantly and has allowed for the first time a (nearly) model-independent extraction of the neutron structure function F2(x ,Q2) in the resonance and deep-inelastic regions. Method: A novel compact radial time projection chamber was built to detect protons with momentum between 70 and 150 MeV/c and over a nearly 4 π angular range. For the extraction of the free-neutron structure function F2n, spectator protons at backward angles (>100∘ relative to the momentum transfer) and with momenta below 100 MeV/c were selected, ensuring that the scattering took place on a nearly free neutron. The scattered electrons were detected with Jefferson Lab's CLAS spectrometer, with data taken at beam energies near 2, 4, and 5 GeV. Results: The extracted neutron structure function F2n and its ratio to the inclusive deuteron structure function F2d are presented in both the resonance and the deep-inelastic regions for momentum transfer squared Q2 between 0.7 and 5 GeV2/c2 , invariant mass W between 1 and 2.7 GeV/c2 , and Bjorken x between 0.25 and 0.6 (in the deep-inelastic scattering region). The dependence of the semi-inclusive cross section on the

  2. Tuning of the Charged Hadrons Multiplicities for Deep Inelastic Interactions in NEUT

    NASA Astrophysics Data System (ADS)

    Bronner, Christophe; Hartz, Mark

    We describe a procedure to tune the charged hadron multiplicities for deep inelastic events produced by the NEUT neutrino interaction generator. This tuning uses a model based on Koba-Nielsen-Olesen scaling, whose parameters are obtained by fitting multiplicity data from deuterium bubble chamber experiments. After tuning, the multiplicities of the events generated by NEUT are found to be in good agreement with the measurements from the bubble chamber experiments.

  3. Measuring Quasi-Elastic e-n and e-p Scattering from Deuterium

    NASA Astrophysics Data System (ADS)

    Balsamo, Alexander; Sherman, Keegan; Gilfoyle, Gerard

    2016-09-01

    The main physics goal of Jefferson Lab is to understand how quarks and gluons form nuclei. We are developing algorithms to extract the relative amounts of electron-neutron (e-n) to electron-proton (e-p) scattering events from deuterium in quasi-elastic (QE) kinematics for an approved experiment with the CLAS12 detector. Our analysis focuses on neutrons detected in the CLAS12 calorimeters and protons measured with the CLAS12 toroidal magnetic field. Events were generated with the Quasi-Elastic Event Generator (QUEEG) and passed through the Monte Carlo code gemc to simulate the CLAS12 response. These simulated events were then reconstructed using CLAS12 Common Tools. We first match the solid angle for e-n and e-p events. The electron information is used to predict the trajectory of both a neutron and proton through CLAS12. If both particles would interact in the CLAS12 volume, we know the sample has the same solid angle for e-n and e-p events. We then select QE events by searching for a nucleon near the predicted position. The angle between the predicted 3-momentum of the nucleon and the measured value, θpq, reaches a peak near zero for QE events, but not for other inelastic events. A cut on θpq separates QE events from inelastic ones. Work supported by the University of Richmond and the US Department of Energy.

  4. Beam-Target Double-Spin Asymmetry ALT in Charged Pion Production from Deep Inelastic Scattering on a Transversely Polarized He3 Target at 1.4<Q2<2.7 GeV2

    SciTech Connect

    Huang, J.; Allada, K.; Dutta, C.; Katich, J.; Qian, X.; Wang, Y.; Zhang, Y.; Aniol, K.; Annand, J. R. M.; Averett, T.; Benmokhtar, F.; Bertozzi, W.; Bradshaw, P. C.; Bosted, P.; Camsonne, A.; Canan, M.; Cates, G. D.; Chen, C.; Chen, J. -P.; Chen, W.; Chirapatpimol, K.; Chudakov, E.; Cisbani, E.; Cornejo, J. C.; Cusanno, F.; Dalton, M. M.; Deconinck, W.; de Jager, C. W.; De Leo, R.; Deng, X.; Deur, A.; Ding, H.; Dolph, P. A. M.; Dutta, D.; El Fassi, L.; Frullani, S.; Gao, H.; Garibaldi, F.; Gaskell, D.; Gilad, S.; Gilman, R.; Glamazdin, O.; Golge, S.; Guo, L.; Hamilton, D.; Hansen, O.; Higinbotham, D. W.; Holmstrom, T.; Huang, M.; Ibrahim, H. F.; Iodice, M.; Jiang, X.; Jin, G.; Jones, M. K.; Kelleher, A.; Kim, W.; Kolarkar, A.; Korsch, W.; LeRose, J. J.; Li, X.; Li, Y.; Lindgren, R.; Liyanage, N.; Long, E.; Lu, H. -J.; Margaziotis, D. J.; Markowitz, P.; Marrone, S.; McNulty, D.; Meziani, Z. -E.; Michaels, R.; Moffit, B.; Muñoz Camacho, C.; Nanda, S.; Narayan, A.; Nelyubin, V.; Norum, B.; Oh, Y.; Osipenko, M.; Parno, D.; Peng, J. C.; Phillips, S. K.; Posik, M.; Puckett, A. J. R.; Qiang, Y.; Rakhman, A.; Ransome, R. D.; Riordan, S.; Saha, A.; Sawatzky, B.; Schulte, E.; Shahinyan, A.; Shabestari, M. H.; Širca, S.; Stepanyan, S.; Subedi, R.; Sulkosky, V.; Tang, L. -G.; Tobias, A.; Urciuoli, G. M.; Vilardi, I.; Wang, K.; Wojtsekhowski, B.; Yan, X.; Yao, H.; Ye, Y.; Ye, Z.; Yuan, L.; Zhan, X.; Zhang, Y. -W.; Zhao, B.; Zheng, X.; Zhu, L.; Zhu, X.; Zong, X.

    2012-01-01

    We report the first measurement of the double-spin asymmetry ALT for charged pion electroproduction in semi-inclusive deep inelastic electron scattering on a transversely polarized 3He target. The kinematics focused on the valence quark region, 0.16 < x < 0.35 with 1.4 < Q2 < 2.7 GeV2. The corresponding neutron ALT asymmetries were extracted from the measured 3He asymmetries and proton/3He cross section ratios using the effective polarization approximation. These new data probe the transverse momentum dependent parton distribution function g1Tq and therefore provide access to quark spin-orbit correlations. Our results indicate a positive azimuthal asymmetry for π- production on 3He and the neutron, while our π+ asymmetries are consistent with zero.

  5. Leading neutron production in e+p collisions at HERA

    NASA Astrophysics Data System (ADS)

    Chekanov, S.; Krakauer, D.; Magill, S.; Musgrave, B.; Pellegrino, A.; Repond, J.; Yoshida, R.; Mattingly, M. C. K.; Antonioli, P.; Bari, G.; Basile, M.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cara Romeo, G.; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; De Pasquale, S.; Giusti, P.; Iacobucci, G.; Levi, G.; Margotti, A.; Nania, R.; Palmonari, F.; Pesci, A.; Sartorelli, G.; Zichichi, A.; Aghuzumtsyan, G.; Bartsch, D.; Brock, I.; Crittenden, J.; Goers, S.; Hartmann, H.; Hilger, E.; Irrgang, P.; Jakob, H.-P.; Kappes, A.; Katz, U. F.; Kerger, R.; Kind, O.; Paul, E.; Rautenberg, J.; Renner, R.; Schnurbusch, H.; Stifutkin, A.; Tandler, J.; Voss, K. C.; Weber, A.; Bailey, D. S.; Brook, N. H.; Cole, J. E.; Foster, B.; Heath, G. P.; Heath, H. F.; Robins, S.; Rodrigues, E.; Scott, J.; Tapper, R. J.; Wing, M.; Capua, M.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Kim, J. Y.; Kim, Y. K.; Lee, J. H.; Lim, I. T.; Pac, M. Y.; Caldwell, A.; Helbich, M.; Liu, X.; Mellado, B.; Paganis, S.; Schmidke, W. B.; Sciulli, F.; Chwastowski, J.; Eskreys, A.; Figiel, J.; Olkiewicz, K.; Przybycień, M. B.; Stopa, P.; Zawiejski, L.; Bednarek, B.; Grabowska-Bold, I.; Jeleń, K.; Kisielewska, D.; Kowal, A. M.; Kowal, M.; Kowalski, T.; Mindur, B.; Przybycień, M.; Rulikowska-Zarȩbska, E.; Suszycki, L.; Szuba, D.; Szuba, J.; Kotański, A.; Słomiński, W.; Bauerdick, L. A. T.; Behrens, U.; Borras, K.; Chiochia, V.; Dannheim, D.; Derrick, M.; Drews, G.; Fourletova, J.; Fox-Murphy, A.; Fricke, U.; Geiser, A.; Goebel, F.; Göttlicher, P.; Gutsche, O.; Haas, T.; Hain, W.; Hartner, G. F.; Hillert, S.; Kötz, U.; Kowalski, H.; Labes, H.; Lelas, D.; Löhr, B.; Mankel, R.; Martínez, M.; Moritz, M.; Notz, D.; Pellmann, I.-A.; Petrucci, M. C.; Polini, A.; Schneekloth, U.; Selonke, F.; Surrow, B.; Wessoleck, H.; Wichmann, R.; Wolf, G.; Youngman, C.; Zeuner, W.; Lopez-Duran Viani, A.; Meyer, A.; Schlenstedt, S.; Barbagli, G.; Gallo, E.; Genta, C.; Pelfer, P. G.; Bamberger, A.; Benen, A.; Coppola, N.; Markun, P.; Raach, H.; Wölfle, S.; Bell, M.; Bussey, P. J.; Doyle, A. T.; Glasman, C.; Hanlon, S.; Lee, S. W.; Lupi, A.; McCance, G. J.; Saxon, D. H.; Skillicorn, I. O.; Gialas, I.; Bodmann, B.; Carli, T.; Holm, U.; Klimek, K.; Krumnack, N.; Lohrmann, E.; Milite, M.; Salehi, H.; Stonjek, S.; Wick, K.; Ziegler, A.; Ziegler, Ar; Collins-Tooth, C.; Foudas, C.; Gonçalo, R.; Long, K. R.; Metlica, F.; Miller, D. B.; Tapper, A. D.; Walker, R.; Cloth, P.; Filges, D.; Kuze, M.; Nagano, K.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Barakbaev, A. N.; Boos, E. G.; Pokrovskiy, N. S.; Zhautykov, B. O.; Lim, H.; Son, D.; Barreiro, F.; González, O.; Labarga, L.; del Peso, J.; Redondo, I.; Terrón, J.; Vázquez, M.; Barbi, M.; Bertolin, A.; Corriveau, F.; Ochs, A.; Padhi, S.; Stairs, D. G.; St-Laurent, M.; Tsurugai, T.; Antonov, A.; Bashkirov, V.; Danilov, P.; Dolgoshein, B. A.; Gladkov, D.; Sosnovtsev, V.; Suchkov, S.; Dementiev, R. K.; Ermolov, P. F.; Golubkov, Yu. A.; Katkov, I. I.; Khein, L. A.; Korzhavina, I. A.; Kuzmin, V. A.; Levchenko, B. B.; Lukina, O. Yu; Proskuryakov, A. S.; Shcheglova, L. M.; Vlasov, N. N.; Zotkin, S. A.; Bokel, C.; Engelen, J.; Grijpink, S.; Koffeman, E.; Kooijman, P.; Maddox, E.; Schagen, S.; Tassi, E.; Tiecke, H.; Tuning, N.; Velthuis, J. J.; Wiggers, L.; de Wolf, E.; Brümmer, N.; Bylsma, B.; Durkin, L. S.; Gilmore, J.; Ginsburg, C. M.; Kim, C. L.; Ling, T. Y.; Boogert, S.; Cooper-Sarkar, A. M.; Devenish, R. C. E.; Ferrando, J.; Grzelak, G.; Matsushita, T.; Rigby, M.; Ruske, O.; Sutton, M. R.; Walczak, R.; Brugnera, R.; Carlin, R.; Dal Corso, F.; Dusini, S.; Garfagnini, A.; Limentani, S.; Longhin, A.; Parenti, A.; Posocco, M.; Stanco, L.; Turcato, M.; Adamczyk, L.; Heaphy, E. A.; Oh, B. Y.; Saull, P. R. B.; Whitmore, J. J.; Iga, Y.; D'Agostini, G.; Marini, G.; Nigro, A.; Cormack, C.; Hart, J. C.; McCubbin, N. A.; Heusch, C.; Park, I. H.; Pavel, N.; Abramowicz, H.; Dagan, S.; Gabareen, A.; Kananov, S.; Kreisel, A.; Levy, A.; Abe, T.; Fusayasu, T.; Kohno, T.; Umemori, K.; Yamashita, T.; Hamatsu, R.; Hirose, T.; Inuzuka, M.; Kitamura, S.; Matsuzawa, K.; Nishimura, T.; Arneodo, M.; Cartiglia, N.; Cirio, R.; Costa, M.; Ferrero, M. I.; Maselli, S.; Monaco, V.; Peroni, C.; Ruspa, M.; Sacchi, R.; Solano, A.; Staiano, A.; Fagerstroem, C.-P.; Galea, R.; Koop, T.; Martin, J. F.; Mirea, A.; Sabetfakhri, A.; Butterworth, J. M.; Gwenlan, C.; Hall-Wilton, R.; Jones, T. W.; Lane, J. B.; Lightwood, M. S.; Loizides, J. H.; West, B. J.; Ciborowski, J.; Ciesielski, R.; Nowak, R. J.; Pawlak, J. M.; Smalska, B.; Sztuk, J.; Tymieniecka, T.; Ukleja, A.; Ukleja, J.; Zakrzewski, J. A.; Żarnecki, A. F.; Adamus, M.; Plucinski, P.; Eisenberg, Y.; Gladilin, L. K.; Hochman, D.; Karshon, U.; Kçira, D.; Lammers, S.; Li, L.; Reeder, D. D.; Savin, A. A.; Smith, W. H.; Deshpande, A.; Dhawan, S.; Hughes, V. W.; Straub, P. B.; Bhadra, S.; Catterall, C. D.; Fourletov, S.; Khakzad, M.; Menary, S.; Soares, M.; Standage, J.; ZEUS Collaboration

    2002-08-01

    The production of neutrons carrying at least 20% of the proton beam energy ( x L> 0.2 ) in e+p collisions has been studied with the ZEUS detector at HERA for a wide range of Q2, the photon virtuality, from photoproduction to deep inelastic scattering. The neutron-tagged cross section, ep→ e' Xn, is measured relative to the inclusive cross section, ep→ e' X, thereby reducing the systematic uncertainties. For xL> 0.3, the rate of neutrons in photoproduction is about half of that measured in hadroproduction, which constitutes a clear breaking of factorisation. There is about a 20% rise in the neutron rate between photoproduction and deep inelastic scattering, which may be attributed to absorptive rescattering in the γp system. For 0.64< xL<0.82, the rate of neutrons is almost independent of the Bjorken scaling variable x and Q2. However, at lower and higher xL values, there is a clear but weak dependence on these variables, thus demonstrating the breaking of limiting fragmentation. The neutron-tagged structure function, FLN(3)2( x, Q2, xL), rises at low values of x in a way similar to that of the inclusive F2( x, Q2) of the proton. The total γπ cross section and the structure function of the pion, Fπ2( xπ, Q2) where xπ= x/(1- xL), have been determined using a one-pion-exchange model, up to uncertainties in the normalisation due to the poorly understood pion flux. At fixed Q2, Fπ2 has approximately the same x dependence as F2 of the proton.

  6. Measurement of Beam-Spin Asymmetries for Deep Inelastic pi{sup +} Electroproduction

    SciTech Connect

    H. Avakian; Volker D. Burkert; Latifa Elouadrhiri; et. al.

    2002-12-01

    We report the first evidence for a non-zero beam-spin azimuthal asymmetry in the electroproduction of positive pions in the deep-inelastic region. Data have been obtained using a polarized electron beam of 4.3 GeV and with the CLAS detector at the Thomas Jefferson National Accelerator Facility (JLab). The amplitude of the sin phi modulation increases with the momentum of the pion relative to the virtual photon, z, with an average amplitude of 0.038+/-0.005+/-0.003 for 0.5

  7. The Excitation of High Spin States with Quasielastic and Deep Inelastic Reactions.

    NASA Astrophysics Data System (ADS)

    Knott, Clinton Neal

    1988-12-01

    The feasibility of populating high spin states using reactions induced by a 220 MeV ^{22 }Ne beam on a ^{170} Er target was studied. The experiment was carried out using a multidetector array for high resolution gamma-ray spectroscopy, a 14 element sum multiplicity spectrometer and six DeltaE-E particle telescopes. Detailed information was obtained concerning the reaction mechanisms associated with various reaction channels. Deep inelastic collisions are shown to be a promising tool for high spin spectroscopy in regions of the chart of nuclides which are not accessible by other reactions.

  8. Population of high spin states by quasi-elastic and deep inelastic collisions

    NASA Astrophysics Data System (ADS)

    Takai, H.; Knott, C. N.; Winchell, D. F.; Saladin, J. X.; Kaplan, M. S.; de Faro, L.; Aryaeinejad, R.; Blue, R. A.; Ronningen, R. M.; Morrissey, D. J.; Lee, I. Y.; Dietzsch, O.

    1988-09-01

    The feasibility of populating high spin states using reactions induced by a 10 MeV/nucleon 22Ne beam on 170Er was studied. The experiment was carried out using a multidetector array for high resolution γ-ray spectroscopy, a 14 element sum-multiplicity spectrometer and six ΔE-E telescopes. Detailed information was obtained concerning the reaction mechanisms associated with various reaction channels. Deep inelastic collisions are shown to be a promising tool for high spin spectroscopy in regions of the chart of nuclides which are not accessible by other reactions.

  9. The excitation of high spin states with quasi-elastic and deep inelastic reactions

    SciTech Connect

    Knott, C.N.

    1988-01-01

    The feasibility of populating high spin states using reactions induced by a 220 MeV {sup 22}Ne beam on a {sup 170}Er target was studied. The experiment was carried out using a multidetector array for high resolution {gamma}-ray spectroscopy, a 14 element sum multiplicity spectrometer and six {Delta}E-E particle telescopes. Detailed information was obtained concerning the reaction mechanisms associated with various reaction channels. Deep inelastic collisions are shown to be a promising tool for high spin spectroscopy in regions of the chart of nuclides which are not accessible by other reactions.

  10. Population of high spin states by quasi-elastic and deep inelastic collisions

    SciTech Connect

    Takai, H.; Knott, C.N.; Winchell, D.F.; Saladin, J.X.; Kaplan, M.S.; de Faro, L.; Aryaeinejad, R.; Blue, R.A.; Ronningen, R.M.; Morrissey, D.J.; and others

    1988-09-01

    The feasibility of populating high spin states using reactions induced by a 10 MeV/nucleon /sup 22/Ne beam on /sup 170/Er was studied. The experiment was carried out using a multidetector array for high resolution ..gamma..-ray spectroscopy, a 14 element sum-multiplicity spectrometer and six ..delta..E-E telescopes. Detailed information was obtained concerning the reaction mechanisms associated with various reaction channels. Deep inelastic collisions are shown to be a promising tool for high spin spectroscopy in regions of the chart of nuclides which are not accessible by other reactions.

  11. Demonstration of imaging X-ray Thomson scattering on OMEGA EP

    NASA Astrophysics Data System (ADS)

    Belancourt, Patrick X.; Theobald, Wolfgang; Keiter, Paul A.; Collins, Tim J. B.; Bonino, Mark J.; Kozlowski, Pawel M.; Regan, Sean P.; Drake, R. Paul

    2016-11-01

    Foams are a common material for high-energy-density physics experiments because of low, tunable densities, and being machinable. Simulating these experiments can be difficult because the equation of state is largely unknown for shocked foams. The focus of this experiment was to develop an x-ray scattering platform for measuring the equation of state of shocked foams on OMEGA EP. The foam used in this experiment is resorcinol formaldehyde with an initial density of 0.34 g/cm3. One long-pulse (10 ns) beam drives a shock into the foam, while the remaining three UV beams with a 2 ns square pulse irradiate a nickel foil to create the x-ray backlighter. The primary diagnostic for this platform, the imaging x-ray Thomson spectrometer, spectrally resolves the scattered x-ray beam while imaging in one spatial dimension. Ray tracing analysis of the density profile gives a compression of 3 ± 1 with a shock speed of 39 ± 6 km/s. Analysis of the scattered x-ray spectra gives an upper bound temperature of 20 eV.

  12. Meson exchange effects in elastic ep scattering at loop level and the electromagnetic form factors of the proton

    NASA Astrophysics Data System (ADS)

    Chen, Hong-Yu; Zhou, Hai-Qing

    2014-10-01

    A new form of two-photon exchange (TPE) effect is studied to explain the discrepancy between unpolarized and polarized experimental data in elastic ep scattering. The mechanism is based on a simple idea that apart from the usual TPE effects from box and crossed-box diagrams, the mesons may also be exchanged in elastic ep scattering by two-photon coupling at loop level. The detailed study shows such contributions to reduced unpolarized cross section (σun) and polarized observables (Pt,Pl) at fixed Q2 are only dependent on proton's electromagnetic form factors GE ,M and a new unknown universal parameter g. After combining this contribution with the usual TPE contributions from box and crossed-box diagrams, the ratio μpGE/GM extracted from the recent precise unpolarized and polarized experimental data can be described consistently.

  13. Access quark information in semi-inclusive deep inelastic scattering at JLab-12GeV

    SciTech Connect

    Jiang, Xiadong

    2009-01-01

    We outline a plan for a detailed study of SIDIS hadron-multiplicities (pion and kaon). The goal of this plan is to firmly establish the kinematic region over which SIDIS reaction can be reliably interpreted to the next-to-leading-order QCD in terms of parton distributions and fragmentation functions.

  14. Semi-Inclusive Deep Inelastic Scattering and Bessel-Weighted Asymmetries

    SciTech Connect

    Gamberg, Leonard; Boer, Daniel; Musch, Bernhard; Prokudin, Alexei

    2011-12-14

    We consider the cross section in Fourier space, conjugate to the outgoing hadron's transverse momentum, where convolutions of transverse momentum dependent parton distribution functions and fragmentation functions become simple products. Individual asymmetric terms in the cross section can be projected out by means of a generalized set of weights involving Bessel functions. Advantages of employing these Bessel weights are that they suppress (divergent) contributions from high transverse momentum and that soft factors cancel in (Bessel-) weighted asymmetries. Also, the resulting compact expressions immediately connect to previous work on evolution equations for transverse momentum dependent parton distribution and fragmentation functions and to quantities accessible in lattice QCD. Bessel-weighted asymmetries are thus model independent observables that augment the description and our understanding of correlations of spin and momentum in nucleon structure.

  15. Measurement of the Target-Normal Single-Spin Asymmetry Ayn in the Deep Inelastic Region from the Reaction 3He(e,e')

    SciTech Connect

    Katich, Joseph

    2011-01-01

    A first measurement of the inclusive target single-spin asymmetry, Any, has been performed in deep-inelastic scattering of electrons from a 3He target polarized normal to the electron scattering plane. This asymmetry is void of contributions at the Born level, and thus is a direct observable for two-photon physics. The experiment was performed in Hall A at Thomas Jefferson National Accelerator Facility from October 2008 through early February 2009. The measurement is the first from a polarized neutron target. The final overall precision is several times better than previously existing SLAC proton data, and significantly extends the kinematic range over which the asymmetry has been measured. The asymmetry was measured at five kinematic points in the deep inelastic scattering region covering Q2 = 1 - 3 GeV2 and xB = 0.16 to 0.41. The asymmetry varied from 0.006 to 0.071 with astatistical precision at the 10-2 level.

  16. Nuclear structure studies of 202Hg and 203Tl using deep-inelastic collisions

    NASA Astrophysics Data System (ADS)

    Gass, Emily; McCutchan, E. A.; Sonzogni, A. A.; Barrett, J. S.; Loveland, W.; Yanez, R.; Zhu, S.; Ayangeakaa, A. D.; Carpenter, M. P.; Greene, J. P.; Janssens, R. V. F.; Lauritsen, T.; Chiara, C. J.; Harker, J. L.; Walters, W. B.

    2016-09-01

    Nuclei with a few valence nucleons outside 208Pb are crucial for testing the nuclear shell model and guiding our understanding of single particle structure. Data in this region are also potentially relevant to nuclear astrophysics. This analysis focused on the high-spin structure of 202Hg and 203Tl. Excited states in these nuclei were populated through deep-inelastic reactions from a beam of 136Xe and that was incident on a thick target of 208Pb in the Gammasphere array at Argonne National Laboratory. The level schemes of 202Hg and 203Tl were extended by locating a new isomer in each nucleus and a number of new high-spin states built on top of the isomers. The newly-observed states will be discussed in the context of the shell model. Supported by US DOE under the SULI Program and Grant Nos. DE-FG06-97ER41026 and DE-FG02-94ER40834 and Contract Nos. DE-AC02-06CH11357 and DE-AC02-06CH10886.

  17. Polarised Parton Densities from the Fits to the Deep Inelastic Spin Asymmetries on Nucleons

    NASA Astrophysics Data System (ADS)

    Bartelski, Jan; Tatur, Stanislaw

    2001-07-01

    We have updated our next to leading order QCD fit for polarised parton densities [S. Tatur, J. Bartelski, M. Kurzela, Acta Phys. Pol. B31, 647 (2000)] using recent experimental data on the deep inelastic spin asymmetries on nucleons. Our distributions have functional form inspired by the unpolarised ones given by MRST (Martin, Roberts, Stirling and Thorne) fit. In addition to usually used data sample (averaged over variable Q2 for the same value of x variable) we have also considered the points with the same x and different Q2. Our fits to both groups of data give very similar results with substantial antiquark contribution in the measured region of x. In the first case we get rather small (Δ G=0.31) gluon polarisation. For the non averaged data the best fit is obtained when gluon contribution vanishes at Q2=1GeV2. Our new parametrisation of parton densities and additional experimental data taken into account do not change much our previous results.

  18. Radiative corrections to the elastic e-p and mu-p scattering in Monte Carlo simulation approach

    NASA Astrophysics Data System (ADS)

    Koshchii, Oleksandr; Afanasev, Andrei; MUSE Collaboration

    2015-04-01

    In this paper, we calculated exactly lepton mass corrections for the elastic e-p and mu-p scatterings using the ELRADGEN 2.1 Monte Carlo generator. These estimations are essential to be used in the MUSE experiment that is designed to solve the proton radius puzzle. This puzzle is due to the fact that two methods of measuring proton radius (the spectroscopy method, which measures proton energy levels in hydrogen, and the electron scattering experiment) predicted the radius to be 0.8768 +/-0.0069 fm, whereas the experiment that used muonic hydrogen provided the value that is 5% smaller. Since the radiative corrections are different for electrons and muons due to their mass difference, these corrections are extremely important for analysis and interpretation of upcoming MUSE data.

  19. W- and Z-boson production at ep colliders

    SciTech Connect

    Baur, U.

    1992-04-01

    We briefly summarize the results of a comprehensive study of W and Z production in high energy ep collisions. The processes ep {yields} vWX{sup {plus_minus}}X, ep {yields} vW{sup {minus}}X, ep {yields} eZX and ep {yields} vZX are investigated. The region of small momentum transfer in eW and eZ production, with a fermion exchanged in the u-channel, is treated using the photon structure function approach, and carefully matched to the deep inelastic region. Low momentum photon exchange contributions to vW and eZ production, where the proton either stays intact or is transformed into a nucleon resonance, are calculated using form factors and structure functions fitted directly to experimental data.

  20. Monte Carlo generator ELRADGEN 2.0 for simulation of radiative events in elastic ep-scattering of polarized particles

    NASA Astrophysics Data System (ADS)

    Akushevich, I.; Filoti, O. F.; Ilyichev, A.; Shumeiko, N.

    2012-07-01

    The structure and algorithms of the Monte Carlo generator ELRADGEN 2.0 designed to simulate radiative events in polarized ep-scattering are presented. The full set of analytical expressions for the QED radiative corrections is presented and discussed in detail. Algorithmic improvements implemented to provide faster simulation of hard real photon events are described. Numerical tests show high quality of generation of photonic variables and radiatively corrected cross section. The comparison of the elastic radiative tail simulated within the kinematical conditions of the BLAST experiment at MIT BATES shows a good agreement with experimental data. Catalogue identifier: AELO_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AELO_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC license, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 1299 No. of bytes in distributed program, including test data, etc.: 11 348 Distribution format: tar.gz Programming language: FORTRAN 77 Computer: All Operating system: Any RAM: 1 MB Classification: 11.2, 11.4 Nature of problem: Simulation of radiative events in polarized ep-scattering. Solution method: Monte Carlo simulation according to the distributions of the real photon kinematic variables that are calculated by the covariant method of QED radiative correction estimation. The approach provides rather fast and accurate generation. Running time: The simulation of 108 radiative events for itest:=1 takes up to 52 seconds on Pentium(R) Dual-Core 2.00 GHz processor.

  1. γZ corrections to forward-angle parity-violating ep scattering

    DOE PAGES

    Alex Sibirtsev; Blunden, Peter G.; Melnitchouk, Wally; ...

    2010-07-30

    We use dispersion relations to evaluate the γZ box contribution to parity-violating electron scattering in the forward limit, taking into account constraints from recent JLab data on electroproduction in the resonance region as well as high energy data from HERA. The correction to the asymmetry is found to be 1.2 +- 0.2% at the kinematics of the JLab Qweak experiment, which is well within the limits required to achieve a 4% measurement of the weak charge of the proton.

  2. Contributions From yZ Box Diagrams to Parity Violating Elastic e-p Scattering

    SciTech Connect

    Benjamin Rislow, Carl Carlson

    2011-06-01

    Parity-violating (PV) elastic electron-proton scattering measures Q-weak for the proton, Q{sub W}{sup p}. To extract Q{sub W}{sup p} from data, all radiative corrections must be well-known. Recently, disagreement on the {gamma}Z box contribution to Q{sub W}{sup p} has prompted the need for further analysis of this term. Here, we support one choice of a debated factor, go beyond the previously assumed equality of electromagnetic and {gamma}Z structure functions, and find an analytic result for one of the {gamma}Z box integrals. Our numerical evaluation of the {gamma}Z box is in agreement within errors with previous reports, albeit somewhat larger in central value, and is within the uncertainty requirements of current experiments.

  3. Rates for inclusive deep-inelastic electroproduction of charm quarks at HERA

    NASA Astrophysics Data System (ADS)

    Riemersma, S.; Smith, J.; van Neerven, W. L.

    1995-02-01

    The coefficient functions for heavy flavour production in deeply inelastic electron hadron scattering have been calculated previously. These functions are so long that no analytic expressions could be published. Therefore we have tabulated them as two-dimensional arrays as is often done for the scale dependent parton densities. Using this computer program we present event rates for charm production at HERA in bins of x and Q2. These rates are insensitive to variations in the factorization and renormalization scale μ.

  4. Microscopic calculations of heavy-residue formation in quasielastic and deep-inelastic collisions below the Fermi energy.

    NASA Astrophysics Data System (ADS)

    Souliotis, G. A.; Shetty, D. V.; Galanopoulos, S.; Yennello, S. J.

    2007-10-01

    During the last several years we have undertaken a systematic study of heavy residues formed in quasi-elastic and deep- inelastic collisions near and below the Fermi energy [1,2]. Presently, we are exploring the possibility of extracting information on the dynamics by comparing our heavy residue data to calculations using microscopic models based on the quantum molecular dynamics approach (QMD). We have performed detailed calculations of QMD type using the recent version of the constrained molecular dynamics code CoMD of M. Papa [3]. CoMD is especially designed for reactions near the Fermi energy. It implements an effective interaction with a nuclear-matter compressibility of K=200 (soft EOS) with several forms of the density dependence of the nucleon-nucleon symmetry potential. CoMD imposes a constraint in the phase space occupation for each nucleon, thus restoring the Pauli principle at each time step of the collision. Results of the calculations and comparisons with our residue data will be presented and discussed in detail. [1] G.A. Souliotis et al., Phys. Rev. Lett. 91, 022701 (2003); Nucl. Instrum. Methods B 204 166 (2003). [2] G.A. Souliotis et al., Phys. Lett. B 588, 35 (2004). [3] M. Papa et al., Phys. Rev. C 64, 024612 (2001).

  5. Next-to-leading order QCD factorization for semi-inclusive deep inelastic scattering at twist 4.

    PubMed

    Kang, Zhong-Bo; Wang, Enke; Wang, Xin-Nian; Xing, Hongxi

    2014-03-14

    Within the framework of a high-twist approach, we calculate the next-to-leading order (NLO) perturbative QCD corrections to the transverse momentum broadening in semi-inclusive hadron production in deeply inelastic e+A collisions, as well as lepton pair production in p+A collisions. With explicit calculations of both real and virtual contributions, we verify, for the first time, the factorization theorem at twist 4 in NLO for the nuclear-enhanced transverse momentum weighted differential cross section and demonstrate the universality of the associated twist-4 quark-gluon correlation function. We also identify the QCD evolution equation for the twist-4 quark-gluon correlation function in a large nucleus, which can be solved to determine the scale dependence of the jet transport parameter in the study of jet quenching.

  6. QCD analysis of nucleon structure functions in deep-inelastic neutrino-nucleon scattering: Laplace transform and Jacobi polynomials approach

    NASA Astrophysics Data System (ADS)

    Nejad, S. Mohammad Moosavi; Khanpour, Hamzeh; Tehrani, S. Atashbar; Mahdavi, Mahdi

    2016-10-01

    We present a detailed QCD analysis of nucleon structure functions x F3(x ,Q2) , based on Laplace transforms and the Jacobi polynomials approach. The analysis corresponds to the next-to-leading order and next-to-next-to-leading order approximations of perturbative QCD. The Laplace transform technique, as an exact analytical solution, is used for the solution of nonsinglet Dokshitzer-Gribov-Lipatov-Altarelli-Parisi evolution equations at low- and large-x values. The extracted results are used as input to obtain the x and Q2 evolution of x F3(x ,Q2) structure functions using the Jacobi polynomials approach. In our work, the values of the typical QCD scale ΛMS¯ (nf) and the strong coupling constant αs(MZ2) are determined for four quark flavors (nf=4 ) as well. A careful estimation of the uncertainties shall be performed using the Hessian method for the valence-quark distributions, originating from the experimental errors. We compare our valence-quark parton distribution functions sets with those of other collaborations, in particular with the CT14, MMHT14, and NNPDF sets, which are contemporary with the present analysis. The obtained results from the analysis are in good agreement with those from the literature.

  7. Constraints on large-x parton distributions from new weak boson production and deep-inelastic scattering data

    DOE PAGES

    Accardi, A.; Brady, L. T.; Melnitchouk, W.; ...

    2016-06-20

    A new set of leading twist parton distribution functions, referred to as "CJ15", is presented, which take advantage of developments in the theoretical treatment of nuclear corrections as well as new data. The analysis includes for the first time data on the free neutron structure function from Jefferson Lab, and new high-precision charged lepton and W-boson asymmetry data from Fermilab, which significantly reduce the uncertainty on the d/u ratio at large values of x.

  8. Light-particle emission as a probe of the rotational degrees of freedom in deep-inelastic reactions

    SciTech Connect

    Sobotka, L.G.

    1982-05-01

    The emission of alpha particles in coincidence with the most deeply inelastic heavy-ion reactions has been studied for /sup 181/Ta/sup +/ /sup 165/Ho at 1354 MeV laboratory energy and /sup nat/Ag + /sup 84/Kr at 664 MeV. Alpha particle energy spectra and angular distributions, in coincidence with a projectile-like fragment, were acquired both in the reaction plane and out of the reaction plane at a fixed in-plane angle. The in-plane data for both systems are employed to show that the bulk of the alpha particles in coincidence with the deep-inelastic exit channel can be explained by evaporation from the fully accelerated fragments. Average velocity diagrams, ..cap alpha..-particle energy spectra as a function of angle in several rest frames, and ..cap alpha..-particle angular distributions are presented. The out-of-plane alpha particle angular distributions and the gamma-ray multiplicities are used to study the transfer and partitioning of angular momentum between the two fragments. For the /sup nat/Ag + /sup 84/Kr system, individual fragment spins are extracted form the alpha particle angular distributions as a function of mass asymmetry while the sum of the fragment spins is derived from the gamma-ray multiplicities. These data, together with the fragment kinetic energies, are consistent with rigid rotation of an intermediate complex consisting of two substantially deformed spheroids in near proximity. These data also indicate that some angular momentum fractionation exists at the largest asymmetries examined. Out-of-plane alpha particle distributions, gamma-ray multiplicities, fragment spins as well as the formalism for the spin evaluation at various levels of sophistication are presented.

  9. Structure of ²⁰⁷Pb populated in ²⁰⁸Pb + ²⁰⁸Pb deep-inelastic collisions*

    DOE PAGES

    Shand, C. M.; Wilson, E.; Podolyák, Zs.; ...

    2015-01-01

    The yrast structure of 207Pb above the 13/2+ isomeric state has been investigated in deep-inelastic collisions of 208Pb and 208Pb at ATLAS, Argonne National Laboratory. New and previously observed transitions were measured using the Gammasphere detector array. The level scheme of 207Pb is presented up to ~ 6 MeV, built using coincidence and γ-ray intensity analyses. In addition, the spin and parity assignments of states were made, based on angular distributions and comparisons to shell model calculations.

  10. Structure of ²⁰⁷Pb populated in ²⁰⁸Pb + ²⁰⁸Pb deep-inelastic collisions*

    SciTech Connect

    Shand, C. M.; Wilson, E.; Podolyák, Zs.; Grawe, H.; Brown, B. A.; Fornal, B.; Janssens, R. V. F.; Bowry, M.; Bunce, M.; Carpenter, M. P.; Carroll, R. J.; Chiara, C. J.; Cieplicka-Oryńczak, N.; Deo, A. Y.; Dracoulis, G. D.; Hoffman, C. R.; Kempley, R. S.; Kondev, F. G.; Lane, G. J.; Lauritsen, T.; Lotay, G.; Reed, M. W.; Regan, P. H.; Rodriguez-Triguero, C.; Seweryniak, D.; Szpak, B.; Walker, P. M.; Zhu, S.

    2015-01-01

    The yrast structure of 207Pb above the 13/2+ isomeric state has been investigated in deep-inelastic collisions of 208Pb and 208Pb at ATLAS, Argonne National Laboratory. New and previously observed transitions were measured using the Gammasphere detector array. The level scheme of 207Pb is presented up to ~ 6 MeV, built using coincidence and γ-ray intensity analyses. In addition, the spin and parity assignments of states were made, based on angular distributions and comparisons to shell model calculations.

  11. Intracardiac electrophysiology study (EPS)

    MedlinePlus

    ... rhythms - EPS; Bradycardia - EPS; Tachycardia - EPS; Fibrillation - EPS; Arrhythmia - EPS; Heart block - EPS ... you have signs of an abnormal heart rhythm ( arrhythmia ). You may need to have other tests before ...

  12. Deeply virtual Compton scattering at 6 GeV

    SciTech Connect

    Jian-ping Chen; Eugene Chudakov; Cornelis De Jager; Javier Gomez; Jens-ole Hansen; John Lerose; Robert Michaels; Joseph Mitchell; Arunava Saha; Bogdan Wojtsekhowski; J. Berthot; Pierre Bertin; Alexandre Deur; Rachele Di Salvo; Lawrence Weinstein; Werner Boeglin; Pete Markowitz; Jeffrey Templon; Paul Gueye; Ting Chang; Alan Nathan; Raffaele De Leo; Luigi Lagamba; Moskov Amarian; Evaristo Cisbani; Salvatore Frullani; Franco Garibaldi; R. Iommi; Mauro Iodice; Guido Urciuoli; Marc Vanderhaeghen; Douglas Higinbotham; Xiaodong Jiang; Pierre Guichon; Yves Roblin; Gail Dodge; Christophe Jutier; Charles Hyde-wright; Franck Sabatie; Luminita Todor; Paul Ulmer

    2000-06-01

    The authors propose a measurement of the Deep Virtual Compton Scattering process (DVCS) ep {yields} ep{gamma} in Hall A at Jefferson Lab with a 6 GeV beam. The authors are able to explore the onset of Q{sup 2} scaling, by measuring a beam helicity asymmetry for Q{sup 2} ranging from 1.5 to 2.5 GeV{sup 2} at x{sub B} {approx} 0.35. At this kinematics, the asymmetry is dominated by the DVCS Bethe-Heitler (BH) interference, which is proportional to the imaginary part of the DVCS amplitude amplified by the full magnitude of the BH amplitude. The imaginary part of the DVCS amplitude is expected to scale early. Indeed, the imaginary part of the forward Compton amplitude measured in deep inelastic scattering (via the optical theorem) scales at Q{sup 2} as low as 1 GeV{sup 2}. If the scaling regime is reached, they make an 8% measurement of the skewed parton distributions (SPD) contributing to the DVCS amplitude. Also, this experiment allows them to separately estimate the size of the higher-twist effects, since they are only suppressed by an additional factor 1/Q compared to the leading-twist term, and have a different angular dependence. They use a polarized electron beam and detect the scattered electron in the HRSe, the real photon in an electromagnetic calorimeter (under construction) and the recoil proton in a shielded scintillator array (to be constructed). This allows them to determine the difference in cross-sections for electrons of opposite helicities. This observable is directly linked to the SPD's. The authors estimate that 25 days of beam (600 hours) are needed to achieve this goal.

  13. Probing Quark-Gluon Structure of Matter with e-p and e-A Reactions

    SciTech Connect

    Jian-Ping Chen

    2011-11-01

    Understanding the strong interaction (QCD) in the truly strong ('non-perturbative') region remains a major challenge in modern physics. Nucleon and nuclei provide natural laboratories to study the strong interaction. The quark-gluon structure of the nucleon and nuclei are important by themselves since they are the main (>99%) part of the visible world. With electroweak interaction well-understood, e-p and e-A are clean means to probe the nucleon and nuclear structure and to study the strong interaction (QCD). Inclusive Deep-Inelastic Scattering (DIS) experiments have provided us with the most extensive information on the unpolarized and longitudinally-polarized parton (quark and gluon) distributions (PDFs). It has becoming clear that transverse spin and transverse structure (both transverse spatial structure via generalized parton distributions (GPDs) and transverse momentum structure via transverse- momentum-dependent distributions (TMDs)) study are crucial for a more complete understanding of the nucleon structure and the dynamics of the strong interaction(QCD). The transverse spin, GPDs and TMDs have been the subjects of increasingly intense theoretical and experimental study recently. With 12 GeV energy upgrade, Jefferson Lab (JLab) will provide the most precise multi-dimensional map of the TMDs and GPDs in the valence quark region through Semi-Inclusive DIS (SIDIS) and Deep-Exclusive experiments, providing a 3-d partonic picture of the nucleon in momentum and spatial spaces. The precision information on TMDs and GPDs will provide access to the quark orbital angular momentum and its correlation with the quark and the nucleon spins. The planned future Electron-Ion Collider (EIC) will enable a precision study of the TMDs and GPDs of the sea quarks and gluons, in addition to completing the study in the valence region. The EIC will also open a new window to study the role of gluons in nuclei.

  14. Transverse Spin Structure of the Nucleon through Target Single Spin Asymmetry in Semi-Inclusive Deep-Inelastic $(e,e^\\prime \\pi^\\pm)$ Reaction at Jefferson Lab

    SciTech Connect

    Gao, H; Chen, J -P; Qian, X; Qiang, Y; Huang, M; Afanasev, A; Anselmino, M; Avakian, H; Cates, G; Chudakov, E; Cisbani, E; de Jager, C; Garibaldi, F; Hu, B T; Jiang, X; Kumar, K S; Li, X M; Lu, H J; Meziani, Z -E; Ma, B -Q; Mao, Y J; Peng, J -C; Prokudin, A; Schlegel, M; Souder, P; Xiao, Z G; Ye, Y; Zhu, L

    2011-01-01

    Jefferson Lab (JLab) 12 GeV energy upgrade provides a golden opportunity to perform precision studies of the transverse spin and transverse-momentum-dependent structure in the valence quark region for both the proton and the neutron. In this paper, we focus our discussion on a recently approved experiment on the neutron as an example of the precision studies planned at JLab. The new experiment will perform precision measurements of target Single Spin Asymmetries (SSA) from semi-inclusive electro-production of charged pions from a 40-cm long transversely polarized $^3$He target in Deep-Inelastic-Scattering kinematics using 11 and 8.8 GeV electron beams. This new coincidence experiment in Hall A will employ a newly proposed solenoid spectrometer (SoLID). The large acceptance spectrometer and the high polarized luminosity will provide precise 4-D ($x$, $z$, $P_T$ and $Q^2$) data on the Collins, Sivers, and pretzelocity asymmetries for the neutron through the azimuthal angular dependence. The full 2$\\pi$ azimuthal angular coverage in the lab is essential in controlling the systematic uncertainties. The results from this experiment, when combined with the proton Collins asymmetry measurement and the Collins fragmentation function determined from the e$^+$e$^-$ collision data, will allow for a quark flavor separation in order to achieve a determination of the tensor charge of the d quark to a 10% accuracy. The extracted Sivers and pretzelocity asymmetries will provide important information to understand the correlations between the quark orbital angular momentum and the nucleon spin and between the quark spin and nucleon spin.

  15. Determination of the weak charge of the proton through parity violating asymmetry measurements in the elastic e+p scattering

    SciTech Connect

    Subedi, Adesh

    2014-12-01

    The Qweak experiment has taken data to make a 2.5% measurement of parity violating elastic e+p asymmetry in the four momentum transfer region of 0.0250 (GeV/c)2. This asymmetry is proportional to the weak charge of the proton, which is related to the weak mixing angle, sin2(theta_W). The final Qweak measurement will provide the most precise measurement of the weak mixing angle below the Z0 pole to test the Standard Model prediction. A description of the experimental apparatus is provided in this dissertation. The experiment was carried out using a longitudinally polarized electron beam of up to 180 microampere on a 34.5 cm long unpolarized liquid hydrogen target. The Qweak target is not only the world's highest cryogenic target ever built for a parity experiment but also is the least noisy target. This dissertation provides a detailed description of this target and presents a thorough analysis of the target performance. Statistical analysis of Run 1 data, collected between Feb - May 2011, is done to extract a blinded parity violating asymmetry of size -299.7 ± 13.4 (stat.) ± 17.2 (syst.) ± 68 (blinding) parts-per-billion. This resulted in a preliminary proton's weak charge of value 0.0865 ± 0.0085, a 9% measurement. Based on this blinded asymmetry, the weak mixing angle was determined to be sin2(theta_W) = 0.23429 ± 0.00211.

  16. Towards a Precision Measurement of Parity-Violating e-p Elastic Scattering at Low Momentum Transfer

    SciTech Connect

    Pan, Jie

    2012-01-01

    The goal of the Q-weak experiment is to make a measurement of the proton's weak charge QWp = 1 - 4 sin2W2(θW2(θWWp by measuring the parity violating asymmetry in elastic electron-proton scattering at low momentum transfer Q2 = 0.026 (GeV/c)2 and forward angles (8 degrees). The anticipated size of the asymmetry, based on the SM, is about 230 parts per billion (ppb). With the proposed accuracy, the experiment may probe new physics beyond Standard Model at the TeV scale. This thesis focuses on my contributions to the experiment, including track reconstruction for momentum transfer determination of the scattering process, and the focal plane scanner, a detector I designed and built to measure the flux profile of scattered electrons on the focal plane of the Q-weak spectrometer to assist in the extrapolation of low beam current tracking results to high beam current. Preliminary results from the commissioning and the first run period of the Q-weak experiment are reported and discussed.

  17. Jet production in muon scattering at Fermilab E665

    SciTech Connect

    Salgado, C.W.; E665 Collaboration

    1993-11-01

    Measurements of multi-jet production rates from Muon-Nucleon and Muon-Nuclei scattering at Fermilab-E665 are presented. Jet rates are defined by the JADE clustering algorithm. Rates in Muon-Nucleon deep-inelastic scattering are compared to Monte Carlo model predictions. Preliminary results from jet production on heavy targets, in the shadowing region, show a higher suppression of two-forward jets as compared to one-forward jet production.

  18. Measurement of D{plus-minus} and D{sup 0} production in deep Inelastic scattering using a lifetime tag at HERA.

    SciTech Connect

    Chekanov, S.; Derrick, M.; Magill, S.; Musgrave, B.; Repond, J.; Yoshida, R.; Nicholass, D.; High Energy Physics; ZEUS Collboration

    2009-10-01

    The production of D{sup {+-}}- and D{sup 0}-mesons has been measured with the ZEUS detector at HERA using an integrated luminosity of 133.6 pb{sup -1}. The measurements cover the kinematic range 5 < Q{sup 2} < 1000 GeV{sup 2}, 0.02 < y < 0.7, 1.5 < p T{sup D} < 15 GeV and |{eta}{sup D}| < 1.6. Combinatorial background to the D-meson signals is reduced by using the ZEUS microvertex detector to reconstruct displaced secondary vertices. Production cross sections are compared with the predictions of next-to-leading-order QCD, which is found to describe the data well. Measurements are extrapolated to the full kinematic phase space in order to obtain the open-charm contribution, F{sub 2}{sup c{bar c}} to the proton structure function, F{sub 2}.

  19. Single Spin Asymmetries in Charged Pion Production from Semi-Inclusive Deep Inelastic Scattering on a Transversely Polarized $^3$He Target

    SciTech Connect

    Qian, X; Allada, K; Huang, J; Katich, J; Wang, Y; Zhang, Y; Aniol, K; Annand, J.R.M.; Averett, T; Benmokhtar, F; Bertozzi, W; Bradshaw, P C; Bosted, P; Camsonne, A; Canan, M; Cates, G D; Chen, C; Chen, J -P; Chen, W; Chirapatpimol, K; Chudakov, E; Cisbani, E; Cornejo, J C; Cusanno, F; Dalton, M M; Deconinck, W; de Jager, C W; De Leo, R; Deng, X; Deur, A; Ding, H; Dolph, P.A.M.; Dutta, D; El Fassi, L; Frullani, S; Gao, H; Garibaldi, F; Gaskell, D; Gilad, S; Gilman, R; Glamazdin, O; Golge, S; Guo, L; Hamilton, D; Hansen, O; Higinbotham, D W; Holmstrom, T; Huang, M; Ibrahim, H F; Iodice, M; Jiang, X; Jin, G; Jones, M K; Kelleher, A; Kim, W; Kolarkar, A; Korsch, W; LeRose, J J; Li, X; Li, Y; Lindgren, R; Liyanage, N; Long, E; Lu, H -J; Margaziotis, D J; Markowitz, P; Marrone, S; McNulty, D; Meziani, Z -E; Michaels, R; Moffit, B; Munoz Camacho, C; Nanda, S; Narayan, A; Nelyubin, V; Norum, B; Oh, Y; Osipenko, M; Parno, D; Peng, J C; Phillips, S K; Posik, M; Puckett, A.J.R.; Qiang, Y; Rakhman, A; Ransome, R D; Riordan, S; Saha, A; Sawatzky, B; Schulte, E; Shahinyan, A; Shabestari, M H; Sirca, S; Stepanyan, S; Subedi, R; Sulkosky, V; Tang, L -G; Tobias, A; Urciuoli, G M; Vilardi, I; Wang, K; Wojtsekhowski, B; Yan, X; Yao, H; Ye, Y; Ye, Z; Yuan, L; Zhan, X; Zhang, Y -W; Zhao, B; Zheng, X; Zhu, L; Zhu, X; Zong, X

    2011-08-01

    We report the first measurement of target single spin asymmetries in the semi-inclusive $^3{He}(e,e'\\pi^\\pm)X$ reaction on a transversely polarized target. The experiment, conducted at Jefferson Lab using a 5.9 GeV electron beam, covers a range of 0.14 $< x <$ 0.34 with 1.3 $

  20. Constraints on large-x parton distributions from new weak boson production and deep-inelastic scattering data

    SciTech Connect

    Accardi, A.; Brady, L. T.; Melnitchouk, W.; Owens, J. F.; Sato, N.

    2016-06-20

    A new set of leading twist parton distribution functions, referred to as "CJ15", is presented, which take advantage of developments in the theoretical treatment of nuclear corrections as well as new data. The analysis includes for the first time data on the free neutron structure function from Jefferson Lab, and new high-precision charged lepton and W-boson asymmetry data from Fermilab, which significantly reduce the uncertainty on the d/u ratio at large values of x.

  1. Constrained gamma-Z interference corrections to parity-violating electron scattering

    SciTech Connect

    Hall, Nathan Luke; Blunden, Peter Gwithian; Melnitchouk, Wally; Thomas, Anthony W.; Young, Ross D.

    2013-07-01

    We present a comprehensive analysis of gamma-Z interference corrections to the weak charge of the proton measured in parity-violating electron scattering, including a survey of existing models and a critical analysis of their uncertainties. Constraints from parton distributions in the deep-inelastic region, together with new data on parity-violating electron scattering in the resonance region, result in significantly smaller uncertainties on the corrections compared to previous estimates. At the kinematics of the Qweak experiment, we determine the gamma-Z box correction to be Re\\box_{gamma-Z}^V = (5.61 +- 0.36) x 10^{-3}. The new constraints also allow precise predictions to be made for parity-violating deep-inelastic asymmetries on the deuteron.

  2. Parity Violation Inelastic Scattering Experiments at 6 GeV and 12 GeV Jefferson Lab

    SciTech Connect

    Sulkosky, Vincent A.; et. al.,

    2015-03-01

    We report on the measurement of parity-violating asymmetries in the deep inelastic scattering and nucleon resonance regions using inclusive scattering of longitudinally polarized electrons from an unpolarized deuterium target. The effective weak couplings C$_{2q}$ are accessible through the deep-inelastic scattering measurements. Here we report a measurement of the parity-violating asymmetry, which yields a determination of 2C$_{2u}$ - C$_{2d}$ with an improved precision of a factor of five relative to the previous result. This result indicates evidence with 95% confidence that the 2C$_{2u}$ - C$_{2d}$ is non-zero. This experiment also provides the first parity-violation data covering the whole resonance region, which provide constraints on nucleon resonance models. Finally, the program to extend these measurements at Jefferson Lab in the 12 GeV era using the Solenoidal Large Intensity Device was also discussed.

  3. Measurement of parity-violating asymmetry in electron-deuteron inelastic scattering

    DOE PAGES

    Wang, D.; Pan, K.; Subedi, R.; ...

    2015-04-01

    The parity-violating asymmetries between a longitudinally-polarized electron beam and an unpolarized deuterium target have been measured recently. The measurement covered two kinematic points in the deep inelastic scattering region and five in the nucleon resonance region. We provide here details of the experimental setup, data analysis, and results on all asymmetry measurements including parity-violating electron asymmetries and those of inclusive pion production and beam-normal asymmetries. The parity-violating deep-inelastic asymmetries were used to extract the electron-quark weak effective couplings, and the resonance asymmetries provided the first evidence for quark-hadron duality in electroweak observables. These electron asymmetries and their interpretation were publishedmore » earlier, but are presented here in more detail.« less

  4. Measurement of parity-violating asymmetry in electron-deuteron inelastic scattering

    SciTech Connect

    Wang, D.; Pan, K.; Subedi, R.; Ahmed, Z.; Allada, K.; Aniol, K. A.; Armstrong, D. S.; Arrington, J.; Bellini, V.; Beminiwattha, R.; Benesch, J.; Benmokhtar, F.; Bertozzi, W.; Camsonne, A.; Canan, M.; Cates, G. D.; Chen, J.-P.; Chudakov, E.; Cisbani, E.; Dalton, M. M.; de Jager, C. W.; De Leo, R.; Deconinck, W.; Deng, X.; Deur, A.; Dutta, C.; Fassi, L. El; Erler, J.; Flay, D.; Franklin, G. B.; Friend, M.; Frullani, S.; Garibaldi, F.; Gilad, S.; Giusa, A.; Glamazdin, A.; Golge, S.; Grimm, K.; Hafidi, K.; Hansen, J.-O.; Higinbotham, D. W.; Holmes, R.; Holmstrom, T.; Holt, R. J.; Huang, J.; Hyde, C. E.; Jen, C. M.; Jones, D.; Kang, Hoyoung; King, P. M.; Kowalski, S.; Kumar, K. S.; Lee, J. H.; LeRose, J. J.; Liyanage, N.; Long, E.; McNulty, D.; Margaziotis, D. J.; Meddi, F.; Meekins, D. G.; Mercado, L.; Meziani, Z.-E.; Michaels, R.; Mihovilovic, M.; Muangma, N.; Mesick, K. E.; Nanda, S.; Narayan, A.; Nelyubin, V.; Nuruzzaman, none; Oh, Y.; Parno, D.; Paschke, K. D.; Phillips, S. K.; Qian, X.; Qiang, Y.; Quinn, B.; Rakhman, A.; Reimer, P. E.; Rider, K.; Riordan, S.; Roche, J.; Rubin, J.; Russo, G.; Saenboonruang, K.; Saha, A.; Sawatzky, B.; Shahinyan, A.; Silwal, R.; Sirca, S.; Souder, P. A.; Suleiman, R.; Sulkosky, V.; Sutera, C. M.; Tobias, W. A.; Urciuoli, G. M.; Waidyawansa, B.; Wojtsekhowski, B.; Ye, L.; Zhao, B.; Zheng, X.

    2015-04-01

    The parity-violating asymmetries between a longitudinally-polarized electron beam and an unpolarized deuterium target have been measured recently. The measurement covered two kinematic points in the deep inelastic scattering region and five in the nucleon resonance region. We provide here details of the experimental setup, data analysis, and results on all asymmetry measurements including parity-violating electron asymmetries and those of inclusive pion production and beam-normal asymmetries. The parity-violating deep-inelastic asymmetries were used to extract the electron-quark weak effective couplings, and the resonance asymmetries provided the first evidence for quark-hadron duality in electroweak observables. These electron asymmetries and their interpretation were published earlier, but are presented here in more detail.

  5. Parity-Violating and Parity-Conserving Asymmetries in e->p and e->N Scattering in the Qweak Experiment

    NASA Astrophysics Data System (ADS)

    Deconinck, Wouter; Qweak Collaboration

    2016-03-01

    The Qweak experiment at Jefferson Lab has made the first determination of the weak charge of the proton in elastic scattering of longitudinally polarized electrons from unpolarized protons at a momentum transfer Q2 of 0.025 (GeV/c)2. To achieve the required precision to measure the small parity-violating asymmetry of -279 parts per billion, we directed a 180 μA 85%-polarized electron beam on a 35 cm long liquid hydrogen target and integrated scattered events in eight azimuthally symmetric fused silica Cerenkov detectors. Based on 4% of the total data collected by the experiment, we find a value for the weak charge of proton in agreement with predictions of the Standard Model. To correct for the contributions from background processes, we conducted several additional parity-violating and parity-conserving asymmetry measurements with different kinematics (elastic and N --> Δ), electron polarization (longitudinal and transverse), and targets (protons, electrons, aluminum, and carbon). In many cases, these ancillary results are first or high-precision measurements as well. I will discuss the analysis and anticipated results of the main experiment with a focus on several of the ancillary results. This work was supported in part by the National Science Foundation under Grant No. PHY-1405857.

  6. Inclusive Inelastic Electron Scattering from Nuclei

    SciTech Connect

    Fomin, Nadia

    2007-10-26

    Inclusive electron scattering from nuclei at large x and Q{sup 2} is the result of a reaction mechanism that includes both quasi-elastic scattering from nucleons and deep inelastic scattering from the quark consitituents of the nucleons. Data in this regime can be used to study a wide variety of topics, including the extraction of nuclear momentum distributions, the infiuence of final state interactions and the approach to y-scaling, the strength of nucleon-nucleon correlations, and the approach to x-scaling, to name a few. Selected results from the recent experiment E02-019 at the Thomas Jefferson National Accelerator Facility will be shown and their relevance discussed.

  7. REVIVING AND UPGRADING OF THE EP DEVICE

    SciTech Connect

    Rodriquez, I.; Higinbotham, D.W.

    2008-01-01

    At Thomas Jefferson National Accelerator Facility, an electron beam is used to probe the fundamental properties of the nucleus. In these experiments, it is essential to know the precise energy of the beam. An important instrument along the beamline to measure the beam energy is the eP device. The device measures the scattered electron angle and the recoil proton angle of an elastic collision. From these angle measurements, the beam energy can be calculated. Many eP device components such as computer software, controls, and mechanical parts needed to be upgraded and/or replaced in order for the eP device to be operational again. A research study was conducted of the current hydrogen target and its properties as well as alternate targets for better performance. As the maximum electron beam energy incident on the eP device will soon be upgraded from 6 GeV to 12 GeV, an analysis was also done on potential changes to the position of the electron and proton detectors in order to accommodate this change. Calculations show that for the new energy upgrade, electron detectors need to be positioned at 5° above and below the beamline to measure the energy of 12 GeV. New proton detectors need to be placed at an angle of 49.2° above and below the beamline to measure energies of 6.6 GeV and 8.8 GeV. With these changes the eP device will measure the range of new energies from 2.2 GeV to 12 GeV. From the target research studies it was found that a carbon nanotube mixture with polypropylene could be the ideal target for the eP device because of its high thermal conductivity and its high hydrogen content. The changes made to the eP device demonstrate the importance of continued research and new technologies.

  8. Jet production in muon-proton and muon-nuclei scattering at Fermilab-E665

    SciTech Connect

    Salgado, C.W.; E665 Collaboration

    1993-08-01

    Measurements of multi-jet production rates from Muon-Proton Muon- Nuclei scattering at Fermilab-E665 are presented. Jet rates are defined by the JADE clustering algorithm. Rates in Muon-Proton deep-inelastic scattering are compared to perturbative Quantum Chromodynamics (PQCD) and Monte Carlo model predictions. We observe hadronic (2+1)-jet rates which are a factor of two higher than PQCD predictions at the partonic level. Preliminary results from jet production on heavy targets, in the shadowing region, show a suppression of the jet rates as compared to deuterium. The two- forward jet sample present higher suppression as compared to the one-forward jet sample.

  9. eP physics at the CBA

    SciTech Connect

    Wiss, J.E.; White, D.H.; Morse, W.M.

    1982-01-01

    In this report we have tried to demonstrate how a 20 x 400 GeV ep facility at the CBA will complement the physics of high energy e/sup -/e/sup +/ and hadron-hadron colliders. An ep collider will extend tests of the standard model by about an order of magnitude in spacelike momentum transfer, and extend our knowledge of electro-weak processes to a remarkable degree. It will be especially interesting to see if the lefthanded nature of the charged current observed at low spacelike momentum transfers persists to large, space momentum transfers. A high energy ep collider is unique in the opportunity to investigate QCD through the scale breaking at high Q/sup 2/ the high P/sub t/ QCD Compton process. In addition to probing small distance behavior in kinematic regions orthogonal to other collider facilities, an ep facility will generate data ultimately crucial to the understanding of the physics of e/sup +/e/sup -/ and hadron-hadron collisions. The current jet that is produced in the high energy ep neutral current process recoils against a single electron which can be used to predict the momentum of the quark which gives rise to the jet. The central problem in jet physics of deducing the kinematics of a quark by measurement of its hadronization jet can be studied under uniquely controlled circumstances. Finally the high Q/sup 2/ structure functions of the proton which are essential in understanding hard processes in hadron-hadron scattering can only be cleanly measured in an ep collider.

  10. eP physics at the CBA

    SciTech Connect

    Wiss, J.E.; White, D.H.; Morse, W.M.

    1982-01-01

    In this report we have tried to demonstrate how a 20 x 400 GeV eP facility at the CBA will complement the future physics of high energy e+e/sup -/ and hadron-hadron colliders. By offering the first glimpse of the physics of 17 TeV muon and neutrino beams, an eP collider will extend tests of the standard model by about an order of magnitude in spacelike momentum transfer, and thus close the final kinematic gap of knowledge about electro-weak processes. It will be especially interesting to test whether the lefthanded nature of the charged current observed at low spacelike momentum transfers persists to large, spacelike momentum transfers. A high energy eP collider also enables unique tests of QCD such as a study of high Q/sup 2/ scale breaking and the high P/sub t/ QCD Compton process. In addition to probing small distance behavior in kinematic regions orthogonal to other collider facilities, an eP facility will generate data useful to understanding the physics of e+e/sup -/ and hadron-hadron collisions. The current jet produced in the high energy eP neutral current process is produced against a single electron which can be used to predict the momentum of the quark which gives rise to the jet. Hence the central problem in jet physics of deducing the kinematics of a quark by measurement of its hadronization jet can be studied under uniquely controlled circumstances. Finally the high Q/sup 2/ structure functions of the proton which are essential in understanding hard process in hadron-hadron scattering can only be cleanly measured in an eP collider.

  11. Enhanced Polar System (EPS)

    DTIC Science & Technology

    2015-12-01

    payloads on classified host satellites in highly elliptical Molniya orbits. EPS is composed of four segments: the eXtended Data Rate (XDR) Payload...facility, as directed by the Naval Undersea Warfare Center in November 2015. The Time Division Multiple Access Interface Processor , which is the Navy...and data correctness, availability and processing requirements in the Joint integrated architecture. interfaces; services; policy-enforcement

  12. Nuclear Effects in Neutrino Scattering at MINERvA

    NASA Astrophysics Data System (ADS)

    Tice, Brian

    2014-09-01

    MINERvA is a neutrino cross section experiment in the NuMI beamline at Fermilab. The MINERvA detector employs fine-grained plastic scintillator (CH) for tracking and calorimetry, and is capable of reconstructing exclusive final states. The detector includes nuclear targets of carbon, iron, lead, liquid helium, and water, with which MINERvA can measure the nuclear dependence of neutrino interactions. Neutrino scattering measurements complement those done with charged leptons, because neutrino scattering directly probes axial structure and is sensitive to the deep inelastic structure function F3. In addition, precise neutrino-nucleus measurements will reduce the significant nuclear model uncertainties incurred by using heavy nuclear targets to obtain high statistics in neutrino experiments. Such nuclear effects include both changes to the interaction cross section and alterations to the final state products through their interactions in the target nucleus. These uncertainties have implications for the utilization of neutrino deep inelastic scattering data in fitting parton distribution functions and for the extraction of neutrino oscillation parameters. We present three recent results from MINERvA that address this need for better knowledge of nuclear effects in neutrino scattering. First, measurements of νμ and νμ quasielastic cross sections. Then, a measurement of charged pion production from inclusive νμ interactions. Lastly, the first measurements of inclusive νμ cross section ratios of carbon, iron, and lead to scintillator as functions of neutrino energy and Bjorken-x. MINERvA is a neutrino cross section experiment in the NuMI beamline at Fermilab. The MINERvA detector employs fine-grained plastic scintillator (CH) for tracking and calorimetry, and is capable of reconstructing exclusive final states. The detector includes nuclear targets of carbon, iron, lead, liquid helium, and water, with which MINERvA can measure the nuclear dependence of neutrino

  13. The single particle dynamics of iodine in the Sachs-Teller regime: An inelastic x-ray scattering study

    SciTech Connect

    Izzo, M. G.; Bencivenga, F.; Di Fonzo, S.; Cunsolo, A.; Verbeni, R.; De Lorenzo, R. Gimenez

    2010-09-28

    The high frequency dynamics of liquid iodine has been investigated by deep inelastic x-ray scattering at exchanged wave-vectors (q) ranging from 2.5 to 15 A{sup -1}. The experimental data have been analyzed in the frame of the Sachs-Teller theory of the molecular spectrum while accounting for final state corrections to the lineshape. The performed data analysis carries insights on physical quantities as relevant as the mean rototranslational kinetic energy and the mean square Laplacian of the intermolecular potential. In both cases the measured values are consistent with corresponding theoretical expectations.

  14. G{sub Ep}/G{sub Mp} ratio by polarization transfer in ep {yields} ep

    SciTech Connect

    Mark K. Jones; Konrad A. Aniol; F.T. Baker; J. Berthot; Pierre Bertin; William Bertozzi; A. Besson; Louis Bimbot; Werner Boeglin; Ed Brash; D. Brown; John Calarco, Larry S. Cardman; C.-C. Chang; Jian-ping Chen; Eugene Chudakov; Steve Churchwell; Evaristo Cisbani; Dan Dale; R. De Leo; Alexandre Deur; Brian Diederich; John Domingo; Martin B. Epstein; Lars Ewell; Kevin Fissum; A. Fleck; Helene Fonvieille; Salvatore Frullani; J. Gao; Franco Garibaldi; Ashot Gasparian; G. Gerstner; Shalev Gilad; Ron Gilman.; Alexander Glamazdin; Charles Glashausser; Javier Gomez; V. Gorbenko; A. Green; Jens-Ole Hansen; Howell, C.R.; Huber, G.M.; Mauro Iodice; Kees de Jager; Stephanie Jaminion; Xiangdong Jiang; William Kahl; James J. Kelly; M. Khayat; Laird H. Kramer; G. Kumbartzki; Michael Kuss; E. Lakuriki; G. Lavessiere; John J. LeRose; Meme Liang; Richard Lindgren; Nilanga Liyanage; George Lolos; R. Macri; Richard Madey; Sergey Malov; Dimitri Margaziotis; Pete Markowitz; Kathy McCormick; Justin McIntyre; R.L. van der Meer; R. Michaels; B.D. Milbrath; Jean Mougey; S.K. Nanda; E.A.J.M. Offerman; Z. Papandreou; Charles F. Perdrisat; Gerassimos G. Petratos; N.M. Piskunov; R.I. Pomatsalyuk; David Prout; Vina Punjabi; Gilles Quemener; Ronald Ransome; Brian Raue; Yves Roblin; Rikki Roche; Gary Rutledge; Paul Rutt; Arun Saha; Teijiro Saito; Adam Sarty; Timothy Smith; P. Sorokin; Steffen Strauch; R. Suleiman; K. Takahashi; Jeff Templon; Luminita Todor; Paul E. Ulmer; Guido M. Urciuoli; Pascal Vernin; B. Vlahovic; H. Voskanyan, H.; Krishni Wijesooriya; Bogdan Wojtsekhowski; R.J. Woo; F. Xiong; George Dan Zainea; Z.-L. Zhou

    2000-02-14

    The ratio of the proton's elastic electromagnetic form factors, G{sub Ep}/G{sub Mp} was obtained by measuring P{sub t} and P{ell}, the transverse and the longitudinal recoil proton polarization, respectively. For elastic ep {yields} ep, G{sub Ep}/G{sub Mp} is proportional to P{sub t}/P{ell}. Simultaneous measurement of P{sub t} and P{ell} in a polarimeter provides good control of the systematic uncertainty. The results for the ratio G{sub Ep}/G{sub Mp} show a systematic decrease as Q{sup 2} increases from 0.5 to 3.5 GeV{sup 2}, indicating for the first time a definite difference in the spatial distribution of charge and magnetization currents in the proton.

  15. EXPERIMENTAL STATUS DVCS epepγ AND en → enγ AT JEFFERSON LAB-HALL A

    NASA Astrophysics Data System (ADS)

    Ferdi, C.

    2005-02-01

    The experiments E00-110 and E03-106 [1] propose to measure the Deep Virtual Compton Scattering process (DVCS) epepγ and en → enγ in Hall A at Jefferson Lab with a 5.75 GeV longitudinally polarized electron beam. The exclusivity requires the High Resolution Spectrometer of the Hall A for the detection of the scattered electron (∆p/p = 10-4), an electromagnetic calorimeter for the detection of the real photon (σ/E < 5%) and a scintillator array for the detection of the third particle. A 1 GHz sampling system allows one to deal with pile-up as expected from running detectors at small angles and high luminosity L = 1037 cm-2 s-1. We will describe the apparatus and will explain the method to extract GPDs and evaluate the contributions from higher twists from the measurement of the cross-section difference.

  16. Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes.

    PubMed

    Konger, R L; Malaviya, R; Pentland, A P

    1998-02-04

    We examined the contribution of specific EP receptors in regulating cell growth. By RT-PCR and northern hybridization, adult human keratinocytes express mRNA for three PGE2 receptor subtypes associated with cAMP signaling (EP2, EP3, and small amounts of EP4). In actively growing, non-confluent primary keratinocyte cultures, the EP2 and EP4 selective agonists, 11-deoxy PGE1 and 1-OH PGE1, caused complete reversal of indomethacin-induced growth inhibition. The EP3/EP2 agonist (misoprostol), and the EP1/EP2 agonist (17-phenyl trinor PGE2), showed less activity. Similar results were obtained with agonist-induced cAMP formation. The ability of exogenous dibutyryl cAMP to completely reverse indomethacin-induced growth inhibition support the conclusion that growth stimulation occurs via an EP2 and/or EP4 receptor-adenylyl cyclase coupled response. In contrast, activation of EP3 receptors by sulprostone, which is virtually devoid of agonist activity at EP2 or EP4 receptors, inhibited bromodeoxyuridine uptake in indomethacin-treated cells up to 30%. Although human EP3 receptor variants have been shown in other cell types to markedly inhibit cAMP formation via a pertussis toxin sensitive mechanisms, EP3 receptor activation and presumably growth inhibition was independent of adenylyl cyclase, suggesting activation of other signaling pathways.

  17. Comparative study of nuclear effects in polarized electron scattering from 3 He

    DOE PAGES

    Ethier, J. J.; Melnitchouk, W.

    2013-11-01

    We present a detailed analysis of nuclear effects in inclusive electron scattering from polarized 3He nuclei for polarization asymmetries, structure functions and their moments, both in the nucleon resonance and deep-inelastic regions. We compare the results of calculations within the weak binding approximation at finite Q2 with the effective polarization ansatz often used in experimental data analyses, and explore the impact of Δ components in the nuclear wave function and nucleon off-shell corrections on extractions of the free neutron structure. Using the same framework we also make predictions for the Q2 dependence of quasielastic scattering from polarized 3He, data onmore » which can be used to constrain the spin-dependent nuclear smearing functions in 3He.« less

  18. QCD Precision Measurements and Structure Function Extraction at a High Statistics, High Energy Neutrino Scattering Experiment: NuSOnG

    SciTech Connect

    Adams, T.; Batra, P.; Bugel, Leonard G.; Camilleri, Leslie Loris; Conrad, Janet Marie; de Gouvea, A.; Fisher, Peter H.; Formaggio, Joseph Angelo; Jenkins, J.; Karagiorgi, Georgia S.; Kobilarcik, T.R.; /Fermilab /Texas U.

    2009-06-01

    We extend the physics case for a new high-energy, ultra-high statistics neutrino scattering experiment, NuSOnG (Neutrino Scattering On Glass) to address a variety of issues including precision QCD measurements, extraction of structure functions, and the derived Parton Distribution Functions (PDFs). This experiment uses a Tevatron-based neutrino beam to obtain a sample of Deep Inelastic Scattering (DIS) events which is over two orders of magnitude larger than past samples. We outline an innovative method for fitting the structure functions using a parameterized energy shift which yields reduced systematic uncertainties. High statistics measurements, in combination with improved systematics, will enable NuSOnG to perform discerning tests of fundamental Standard Model parameters as we search for deviations which may hint of 'Beyond the Standard Model' physics.

  19. Measurement of ep-->ep[pi]0 beam spin asymmetries above the resonance region

    SciTech Connect

    De Masi, Rita; Garcon, Michel; Zhao, Bo; Amaryan, Moscov; Amaryan, Moskov; Ambrozewicz, Pawel; Anghinolfi, Marco; Asryan, Gegham; Avagyan, Harutyun; Baghdasaryan, Hovhannes; Baillie, Nathan; Ball, J.P.; Ball, Jacques; Ball, J.P.; Ball, Jacques; Ball, James; Baltzell, Nathan; Baturin, Vitaly; Battaglieri, Marco; Bedlinskiy, Ivan; Bellis, Matthew; Benmouna, Nawal; Berman, Barry; Bertin, Pierre; Biselli, Angela; Blaszczyk, Lukasz; Bouchigny, Sylvain; Boyarinov, Sergey; Bradford, Robert; Branford, Derek; Briscoe, William; Brooks, William; Bultmann, S.; Bueltmann, Stephen; Bultmann, S.; Bueltmann, Stephen; Burkert, Volker; Butuceanu, Cornel; Calarco, John; Careccia, Sharon; Carman, Daniel; Casey, Liam; Chen, Shifeng; Cheng, Lu; Cole, Philip; Collins, Patrick; Coltharp, Philip; Crabb, Donald; Crede, Volker; Dashyan, Natalya; De Sanctis, Enzo; De Vita, Raffaella; Degtiarenko, Pavel; Deur, Alexandre; Dharmawardane, Kahanawita; Dickson, Richard; Djalali, Chaden; Dodge, Gail; Donnelly, Joseph; Doughty, David; Dugger, Michael; Dzyubak, Oleksandr; Egiyan, Hovanes; Egiyan, Kim; Elfassi, Lamiaa; Elouadrhiri, Latifa; Eugenio, Paul; Fedotov, Gleb; Feldman, Gerald; Fradi, Ahmed; Funsten, Herbert; Gavalian, Gagik; Gilfoyle, Gerard; Giovanetti, Kevin; Girod, Francois-Xavier; Goetz, John; Gonenc, Atilla; Gothe, Ralf; Griffioen, Keith; Guidal, Michel; Guler, Nevzat; Guo, Lei; Gyurjyan, Vardan; Hafidi, Kawtar; Hakobyan, Hayk; Hanretty, Charles; Hersman, F.; Hicks, Kenneth; Hleiqawi, Ishaq; Holtrop, Maurik; Hyde, Charles; Ilieva, Yordanka; Ireland, David; Ishkhanov, Boris; Isupov, Evgeny; Ito, Mark; Jenkins, David; Jo, Hyon-Suk; Johnstone, John; Joo, Kyungseon; Juengst, Henry; Kalantarians, Narbe; Kellie, James; Khandaker, Mahbubul; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Klimenko, Alexei; Kossov, Mikhail; Krahn, Zebulun; Kramer, Laird; Kubarovsky, Valery; Kuhn, Joachim; Kuhn, Sebastian; Kuleshov, Sergey; Lachniet, Jeff; Laget, Jean; Langheinrich, Jorn; Lawrence, David; Lee, Tsung-Shung; Livingston, Kenneth; Lu, Haiyun; MacCormick, Marion; Markov, Nikolai; Mattione, Paul; Mazouz, Malek; McKinnon, Bryan; Mecking, Bernhard; Mestayer, Mac; Meyer, Curtis; Mibe, Tsutomu; Michel, Bernard; Mikhaylov, Konstantin; Mirazita, Marco; Miskimen, Rory; Mokeev, Viktor; Moreno, Brahim; Moriya, Kei; Morrow, Steven; Moteabbed, Maryam; Munevar Espitia, Edwin; Mutchler, Gordon; Nadel-Turonski, Pawel; Nasseripour, Rakhsha; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria-Ioana; Niczyporuk, Bogdan; Niroula, Megh; Niyazov, Rustam; Nozar, Mina; Osipenko, Mikhail; Ostrovidov, Alexander; Park, Kijun; Pasyuk, Evgueni; Paterson, Craig; Pereira, Sergio; Pierce, Joshua; Pivnyuk, Nikolay; Pocanic, Dinko; Pogorelko, Oleg; Pozdnyakov, Sergey; Price, John; Procureur, Sebastien; Prok, Yelena; Protopopescu, Dan; Raue, Brian; Ricco, Giovanni; Ripani, Marco; Ritchie, Barry; Ronchetti, Federico; Rosner, Guenther; Rossi, Patrizia; Sabatie, Franck; Salamanca, Julian; Salgado, Carlos; Santoro, Joseph; Sapunenko, Vladimir; Schumacher, Reinhard; Serov, Vladimir; Sharabian, Youri; Sharov, Dmitri; Shvedunov, Nikolay; Smith, Elton; Smith, Lee; Sober, Daniel; Sokhan, Daria; Stavinsky, Aleksey; Stepanyan, Samuel; Stepanyan, Stepan; Stokes, Burnham; Stoler, Paul; Strakovski, Igor; Strauch, Steffen; Taiuti, Mauro; Tedeschi, David; Tkabladze, Avtandil; Tkachenko, Svyatoslav; Tur, Clarisse; Ungaro, Maurizio; Vineyard, Michael; Vlassov, Alexander; Voutier, Eric; Watts, Daniel; Weinstein, Lawrence; Weygand, Dennis; Williams, Michael; Wolin, Elliott; Wood, Michael; Yegneswaran, Amrit; Zana, Lorenzo; Zhang, Jixie; Zhao, Zhiwen

    2008-04-01

    The beam spin asymmetry (BSA) in the exclusive reaction e-vector p-->eppi0 was measured with the CEBAF 5.77 GeV polarized electron beam and Large Acceptance Spectrometer (CLAS). The xB,Q2,t, and phi dependences of the pi0 BSA are presented in the deep inelastic regime. The asymmetries are fitted with a sinphi function and their amplitudes are extracted. Overall, they are of the order of 0.04â 0.11 and roughly independent of t. This is the signature of a nonzero longitudinal-transverse interference. The implications concerning the applicability of a formalism based on generalized parton distributions, as well as the extension of a Regge formalism at high photon virtualities, are discussed.

  20. Current Concepts for PrEP Adherence

    PubMed Central

    Haberer, Jessica E.

    2016-01-01

    Purpose of review This review describes 1) the current understanding of adherence to oral PrEP, 2) methods for adherence measurement, 3) approaches to supporting PrEP adherence, and 4) guidance for defining PrEP adherence goals within the larger context of HIV prevention. Recent findings PrEP adherence has generally been higher in recent trials, open-label extensions, and demonstration projects compared to the initial clinical trials; potential explanations include known PrEP efficacy and different motivations to take PrEP. Recent studies have explored adherence monitoring through electronic pill containers, short message service (SMS), and drug concentrations in hair and dried blood spots. The few PrEP adherence interventions developed to date include combinations of enhanced counseling, feedback of objective adherence measurement, and SMS. Conceptualization of PrEP adherence is evolving. The goal is not 100% adherence indefinitely, as it was in clinical trials. PrEP adherence should be defined with respect to HIV exposure, which varies over time by sexual behavior and use of other prevention strategies. Summary PrEP adherence beyond clinical trials has generally been high enough to achieve reliable HIV prevention. Future efforts to measure and support PrEP adherence should focus on the context of risk for HIV acquisition, accounting for dynamic behaviors and choices among HIV prevention options. PMID:26633638

  1. Light dark matter in neutrino beams: Production modeling and scattering signatures at MiniBooNE, T2K, and SHiP

    NASA Astrophysics Data System (ADS)

    deNiverville, Patrick; Chen, Chien-Yi; Pospelov, Maxim; Ritz, Adam

    2017-02-01

    We analyze the prospects for detection of light sub-GeV dark matter produced in experiments designed to study the properties of neutrinos, such as MiniBooNE, T2K, SHiP, DUNE etc. We present an improved production model, when dark matter couples to hadronic states via a dark photon or baryonic vector mediator, incorporating bremsstrahlung of the dark vector. In addition to elastic scattering, we also study signatures of light dark matter undergoing deep inelastic or quasielastic NC π0 -like scattering in the detector producing neutral pions, which for certain experiments may provide the best sensitivity. Supplemental Material provides extensive documentation for a publicly available simulation tool BdNMC that can be applied to determine the hidden sector dark matter production and scattering rate at a range of proton fixed target experiments.

  2. The detection of EpCAM+ and EpCAM– circulating tumor cells

    PubMed Central

    Wit, Sanne de; Dalum, Guus van; Lenferink, Aufried T. M.; Tibbe, Arjan G. J.; Hiltermann, T. Jeroen N.; Groen, Harry J. M.; van Rijn, Cees J. M.; Terstappen, Leon W. M. M.

    2015-01-01

    EpCAM expressing circulating tumor cells, detected by CellSearch, are predictive of short survival in several cancers and may serve as a liquid biopsy to guide therapy. Here we investigate the presence of EpCAM+ CTC detected by CellSearch and EpCAM– CTC discarded by CellSearch, after EpCAM based enrichment. EpCAM– CTC were identified by filtration and fluorescent labelling. This approach was validated using different cell lines spiked into blood and evaluated on blood samples of 27 metastatic lung cancer patients. The majority of spiked EpCAM+ cells could be detected with CellSearch, whereas most spiked cells with EpCAMlow or EpCAM– expression were detected using filtration. Five or more CTC were detected in 15% of the patient samples, this increased to 41% when adding the CTC detected in the discarded blood. The number of patients with CTC and the number of CTC detected were doubled by the presence of EpCAM– CTC. In this pilot study, the presence of EpCAM+ CTC was associated with poor outcome, whereas the EpCAM– CTC were not. This observation will need to be confirmed in larger studies and molecular characterization needs to be conducted to elucidate differences between EpCAM– and EpCAM+ CTC. PMID:26184843

  3. A precise measurement of the weak mixing angle in neutrino-nucleon scattering

    NASA Astrophysics Data System (ADS)

    Zeller, Geralyn P.

    This dissertation reports a precise determination of the weak mixing angle, sin2 thetaW, from measurement of the ratios of neutral current to charged current neutrino deep inelastic cross sections. High statistics samples of separately collected neutrino and antineutrino events, resulting from exposure to the Fermilab neutrino beam during the period from 1996 to 1997, allowed the reduction of systematic errors associated with charm production and other sources. The final value, sin 2 thetaW(on shell) = 0.2277 +/- 0.0013 (stat) +/- 0.0009 (syst), lies three standard deviations above the standard model prediction. The measurement is currently the most precise determination of sin2 theta W in neutrino-nucleon scattering, surpassing its predecessors by a factor of two in precision. A model independent analysis recasts the same data into a measurement of effective left and right handed neutral current quark couplings.

  4. Forward virtual Compton scattering and the Lamb shift in chiral perturbation theory

    SciTech Connect

    Nevado, David; Pineda, Antonio

    2008-03-15

    We compute the spin-independent structure functions of the forward virtual-photon Compton tensor of the proton at one loop using heavy baryon chiral perturbation theory and dispersion relations. We study the relation between both approaches. We use these results to generalize some sum rules to virtual photon transfer momentum and relate them with sum rules in deep inelastic scattering. We then compute the leading chiral term of the polarizability correction to the Lamb shift of hydrogen and muonic hydrogen. We obtain -87.05/n{sup 3}Hz and -0.148/n{sup 3}meV for the correction to the hydrogen and muonic hydrogen Lamb shift, respectively.

  5. ep Collider experiments and physics

    SciTech Connect

    Atwood, D.; Baur, U.; Bluemlein, J.

    1992-12-31

    The physics prospects for detectors at ep colliders are examined. Colliders considered include the HERA facility at DESY, LEP I {times} LHC, and LEP II {times} LHC at CERN. Physics topics studied include machine energy and polarization, as well as detector resolution, calibration, jet identification and backgrounds from beam-gas interactions. QCD topics include measurements of the quark and gluon structure functions and parton distributions, as well as the expansion of the observable cross section into angular functions. Electroweak topics include measurements of the weak mixing angle, radiative corrections, and WW{gamma} (WWZ) couplings. Topics beyond the standard model include observation of new Z`s, indirect production of Leptoquarks, pair production of sfermions and searches for R-parity-violating SUSY particle production.

  6. Equivalency Programmes (EPs) for Promoting Lifelong Learning

    ERIC Educational Resources Information Center

    Haddad, Caroline, Ed.

    2006-01-01

    Equivalency programmes (EPs) refers to alternative education programmes that are equivalent to the formal education system in terms of curriculum and certification, policy support mechanisms, mode of delivery, staff training, and other support activities such as monitoring, evaluation and assessment. The development of EPs is potentially an…

  7. Measurement of single-target spin asymmetries in the electroproduction of negative pions in the semi-inclusive deep inelastic reaction n(e,e'π-)X on a transversely polarized 3He target

    SciTech Connect

    Dutta, Chiranjib

    2010-06-14

    The experiment E06010 measured the target single spin asymmetry (SSA) in the semiinclusive deep inelastic (SIDIS) n(e,e'π-)X reaction with a transversely polarized 3He target as an e ective neutron target. This is the very rst independent measurement of the neutron SSA, following the measurements at HERMES and COMPASS on the proton and the deuteron. The experiment acquired data in Hall A at Je erson Laboratory with a continuous electron beam of energy 5.9 GeV, probing the valence quark region, with x = 0.13 → 0.41, at Q2 = 1.31 → 3.1 GeV2. The two contributing mechanisms to the measured asymmetry, viz, the Collins effect and the Sivers effect can be realized through the variation of the asymmetry as a function of the Collins and Sivers angles. The neutron Collins and Sivers moments, associated with the azimuthal angular modulations, are extracted from the measured asymmetry for the very first time and are presented in this thesis. The kinematics of this experiment is comparable to the HERMES proton measurement. However, the COMPASS measurements on deuteron and proton are in the low-x region. The results of this experiment are crucial as the first step toward the extraction of quark transversity and Sivers distribution functions in SIDIS. With the existing results on proton and deuteron, these new results on neutron will provide powerful constraints on the transversity and Sivers distributions of both the u and d-quarks in the valence region.

  8. Comparative study of nuclear effects in polarized electron scattering from 3 He

    SciTech Connect

    Ethier, J. J.; Melnitchouk, W.

    2013-11-01

    We present a detailed analysis of nuclear effects in inclusive electron scattering from polarized 3He nuclei for polarization asymmetries, structure functions and their moments, both in the nucleon resonance and deep-inelastic regions. We compare the results of calculations within the weak binding approximation at finite Q2 with the effective polarization ansatz often used in experimental data analyses, and explore the impact of Δ components in the nuclear wave function and nucleon off-shell corrections on extractions of the free neutron structure. Using the same framework we also make predictions for the Q2 dependence of quasielastic scattering from polarized 3He, data on which can be used to constrain the spin-dependent nuclear smearing functions in 3He.

  9. EP300 — EDRN Public Portal

    Cancer.gov

    EP300, or E1A binding protein p300, functions as a histone acetyltransferase and regulates transcription via chromatin remodeling. EP300 is important in the processes of cell proliferation and differentiation, and also functions as acetyltransferase for nonhistone targets. EP300 mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.

  10. H1 search for a narrow baryonic resonance decaying to K{sub S}{sup 0}p(p-bar)

    SciTech Connect

    Risler, Christiane

    2005-10-06

    Preliminary results from the H1 experiment on the search for the production of a candidate for the strange pentaquark in the decay channel {theta}{sup +} {yields} K{sub s}{sup 0}p and its antiparticle in the invariant mass combinations of K{sub s}{sup 0} mesons with protons and antiprotons in deep-inelastic ep-scattering at HERA are presented.

  11. Pre-Exposure Prophylaxis (PrEP)

    MedlinePlus

    ... Sites Podcasts QR Codes RSS Feeds Social Bookmarking Social Network Sites Text Messaging Twitter Video Games Video Sharing ... PrEP be considered for people who are HIV-negative and at very high risk for HIV infection . ...

  12. EPS forces in Bacillus subtilis biofilms

    NASA Astrophysics Data System (ADS)

    Zhang, Wenbo; Angelini, Thomas; Tsai, Shih-Ming; Nixon, Ryan

    2014-03-01

    Bacteria have evolved to congregate in complex communities known as biofilms. The structure that holds a biofilm together is a matrix called extracellular polymeric substance (EPS). It has been observed in previous studies that EPS up-regulation occurs when the nutrient levels fall below a threshold concentration; this increase in EPS concentration produces an osmotic pressure that forces the colony to spread outward. This osmotic pressure may drive nutrient uptake, but the stresses generated by the EPS matrix has never been measured. Here we present measurements of the forces exerted by a biofilm on its supporting substrate and on its fluid nutrients. In our experiments, we use a technique analogous to traction force microscopy to measure strain in agar nutrient substrates imposed by Bacillus subtilis biofilms. By running additional test to measure the permeability and elastic modulus of the agar, we can estimate the pressure generated by the biofilm.

  13. NS/EP Implications of Electronic Commerce

    DTIC Science & Technology

    1999-06-01

    THE PRESIDENT’S NATIONAL SECURITY TELECOMMUNICATIONS ADVISORY COMMITTEE NS/EP IMPLICATIONS OF ELECTRONIC COMMERCE JUNE 1999 Form SF298 Citation Data... Electronic Commerce Procedures Contract or Grant Number Program Element Number Authors Project Number Task Number Work Unit Number Performing Organization...99 3. REPORT TYPE AND DATES COVERED Report 4. TITLE AND SUBTITLE NS/EP Implications of Electronic Commerce 5. FUNDING NUMBERS 6. AUTHOR(S) President’s

  14. PrEP: controversy, agency and ownership

    PubMed Central

    Cairns, Gus P; Race, Kane; Goicochea, Pedro

    2016-01-01

    Pre-exposure prophylaxis (PrEP) has been and continues to be an intervention that causes controversy and debate between stakeholders involved in providing or advocating for it, and within communities in need of it. These controversies extend beyond the intrinsically complex issues of making it available. In this commentary, some of the possible roots of the air of dissent and drama that accompanies PrEP are explored. The similarities between the controversies that dogged the earliest human trials of PrEP and the ones we see today in the era of licensing and implementation are explored. We outline five mediating principles or cultural norms that may influence arguments about PrEP differently. Three areas of specific concern are identified: medical risk versus benefit, distrust and fear of healthcare interventions, and fears for individual responsibility and community cohesion. The fear that PrEP may somehow represent a loss of control over one or more of these domains is suggested as an underlying factor. The development of countervailing measures, to institute greater community “ownership” of PrEP, and concomitant improvements in the sense of individual agency over sexual risk are outlined and recommended. PMID:27760689

  15. Fluid flow shear stress upregulates prostanoid receptor EP2 but not EP4 in murine podocytes.

    PubMed

    Srivastava, Tarak; McCarthy, Ellen T; Sharma, Ram; Kats, Alexander; Carlton, Carol G; Alon, Uri S; Cudmore, Patricia A; El-Meanawy, Ashraf; Sharma, Mukut

    2013-01-01

    Podocytes in the glomerular filtration barrier regulate the passage of plasma proteins into urine. Capillary pressure and ultrafiltration impact the structure and function of podocytes. The mechanism of podocyte injury by fluid flow shear stress (FFSS) from hyperfiltration in chronic kidney disease (CKD) is not completely understood. Recently, we demonstrated increased synthesis of prostaglandin E2 in podocytes exposed to FFSS. Here, we determine the effect of FFSS on prostanoid receptors EP1-EP4 in cultured podocytes and in Os/+ mouse kidney, a model of hyperfiltration. Results of RT-PCR, qRT-PCR, immunoblotting and immunofluorescence studies indicate that cultured podocytes express EP1, EP2 and EP4 but not EP3. FFSS resulted in upregulated expression of only EP2 in podocytes. Kidney immunostaining showed significantly increased expression of EP2 in Os/+ mice compared with littermate controls. These novel results suggest that EP2 may be responsible for mediating podocyte injury from hyperfiltration-induced augmented FFSS in CKD.

  16. Up-regulation of prostaglandin E receptor EP2 and EP4 subtypes in rat synovial tissues with adjuvant arthritis

    PubMed Central

    Kurihara, Y; Endo, H; Akahoshi, T; Kondo, H

    2001-01-01

    To evaluate the role of the prostaglandin E receptor (EP) subtypes in the development of inflammatory synovitis, we examined EP subtype mRNA distribution in the synovial tissue of rats with adjuvant arthritis and the effect of selective EP agonists on cytokine production by cultured rat synovial cells. We used reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridization to measure the level of EP subtype (EP1, EP2, EP3, and EP4) mRNA expression in synovial tissues and cultured synovial cells from the arthritic joints of rats. RT-PCR and ELISA were used to analyse the effects of two selective EP agonists on IL-6 production by cultured rat synovial cells. EP2 and EP4 mRNA expression in inflamed synovial tissues was up-regulated. EP2 and EP4 mRNA were co-expressed in synovial macrophages and fibroblasts in inflamed tissues. EP4 and EP2 agonists both inhibited IL-1-induced IL-6 production. Our results suggest that prostaglandin E2 regulates the functions of synovial macrophages and fibroblasts through EP2 and EP4, which are induced by inflammatory stimuli in rats with adjuvant arthritis. PMID:11207665

  17. Up-regulation of prostaglandin E receptor EP2 and EP4 subtypes in rat synovial tissues with adjuvant arthritis.

    PubMed

    Kurihara, Y; Endo, H; Akahoshi, T; Kondo, H

    2001-02-01

    To evaluate the role of the prostaglandin E receptor (EP) subtypes in the development of inflammatory synovitis, we examined EP subtype mRNA distribution in the synovial tissue of rats with adjuvant arthritis and the effect of selective EP agonists on cytokine production by cultured rat synovial cells. We used reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridization to measure the level of EP subtype (EP1, EP2, EP3, and EP4) mRNA expression in synovial tissues and cultured synovial cells from the arthritic joints of rats. RT-PCR and ELISA were used to analyse the effects of two selective EP agonists on IL-6 production by cultured rat synovial cells. EP2 and EP4 mRNA expression in inflamed synovial tissues was up-regulated. EP2 and EP4 mRNA were co-expressed in synovial macrophages and fibroblasts in inflamed tissues. EP4 and EP2 agonists both inhibited IL-1-induced IL-6 production. Our results suggest that prostaglandin E2 regulates the functions of synovial macrophages and fibroblasts through EP2 and EP4, which are induced by inflammatory stimuli in rats with adjuvant arthritis.

  18. Extracellular polymeric substances (EPS) in a hybrid growth membrane bioreactor (HG-MBR): viscoelastic and adherence characteristics.

    PubMed

    Ying, Wang; Yang, Fei; Bick, Amos; Oron, Gideon; Herzberg, Moshe

    2010-11-15

    Extracellular polymeric substances (EPS) comprising the microbial biofilms in membrane bioreactor (MBR) systems are considered the most significant factor affecting sludge viscoelastic properties as well as membrane fouling. Understanding the water chemistry effects on EPS viscoelastic, conformational, and adherence properties are critical for defining the microbial biofilm's propensity of fouling the membrane surface. In this study, EPS extracted from a hybrid growth membrane bioreactor (HG-MBR) were analyzed for their adherence, viscoelastic properties and size distribution using quartz crystal microbalance with dissipation monitoring (QCM-D) and dynamic light scattering (DLS), respectively. Also, adsorption characteristics of EPS extracted from different locations in the HG-MBR (bioreactor liquor, fluidized carriers, and membrane surface) were defined and linked to the extent of the total polysaccharide content in the EPS. In accordance with the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory, more EPS were adsorbed at higher ionic strength, lower pH and in the presence of calcium cations. Based on the QCM-D results, the calculated thickness of the EPS adsorbed layer was increased at lower ionic strength, higher pH, and only had a minor increase in the presence of calcium cations. The calculated shear modules and shear viscosity suggest that at lower pH and in the presence of calcium, EPS becomes more viscous and elastic, respectively. DLS analysis correlated to the QCM-D results: A decrease in the hydrodynamic radius of the EPS colloids was observed at lower pH, and in the presence of calcium, most likely attributed to intermolecular attraction forces. Based on this study, low pH and presence of calcium may induce flocs' stability that resist erosion in the MBRs, while on the other hand, these conditions may induce the formation of an elastic and viscous EPS layer fouling the ultrafiltration (UF) membrane.

  19. EP2 Receptor Signaling Regulates Microglia Death

    PubMed Central

    Yang, Myung-Soon; Jiang, Jianxiong; Ganesh, Thota; Joe, Eunhye; Dingledine, Raymond

    2015-01-01

    The timely resolution of inflammation prevents continued tissue damage after an initial insult. In the brain, the death of activated microglia by apoptosis has been proposed as one mechanism to resolve brain inflammation. How microglial death is regulated after activation is still unclear. We reported that exposure to lipopolysaccharide (LPS) and interleukin (IL)-13 together initially activates and then kills rat microglia in culture by a mechanism dependent on cyclooxygenase-2 (COX-2). We show here that activation of the E prostanoid receptor 2 (EP2, PTGER2) for prostaglandin E2 mediates microglial death induced by LPS/IL-13, and that EP2 activation by agonist alone kills microglia. Both EP2 antagonists and reactive oxygen scavengers block microglial death induced by either LPS/IL-13 or EP2 activation. By contrast, the homeostatic induction of heme oxygenase 1 (Hmox1) by LPS/IL-13 or EP2 activation protects microglia. Both the Hmox1 inducer cobalt protoporphyrin and a compound that releases the Hmox1 product carbon monoxide (CO) attenuated microglial death produced by LPS/IL-13. Whereas CO reduced COX-2 protein expression, EP2 activation increased Hmox1 and COX-2 expression at both the mRNA and protein level. Interestingly, caspase-1 inhibition prevented microglial death induced by either LPS/IL-13 or low (but not high) concentrations of butaprost, suggestive of a predominantly pyroptotic mode of death. Butaprost also caused the expression of activated caspase-3 in microglia, pointing to apoptosis. These results indicate that EP2 activation, which initially promotes microglial activation, later causes delayed death of activated microglia, potentially contributing to the resolution phase of neuroinflammation. PMID:25715797

  20. Transverse momentum at work in high-energy scattering experiments

    NASA Astrophysics Data System (ADS)

    Signori, Andrea

    2017-01-01

    I will review some aspects of the definition and the phenomenology of Transverse-Momentum-Dependent distributions (TMDs) which are potentially interesting for the physics program at several current and future experimental facilities. First of all, I will review the definition of quark, gluon and Wilson loop TMDs based on gauge invariant hadronic matrix elements. Looking at the phenomenology of quarks, I will address the flavor dependence of the intrinsic transverse momentum in unpolarized TMDs, focusing on its extraction from Semi-Inclusive Deep-Inelastic Scattering. I will also present an estimate of its impact on the transverse momentum spectrum of W and Z bosons produced in unpolarized hadronic collisions and on the determination of the W boson mass. Moreover, the combined effect of the flavor dependence and the evolution of TMDs with the energy scale will be discussed for electron-positron annihilation. Concerning gluons, I will present from an effective theory point of view the TMD factorization theorem for the transverse momentum spectrum of pseudoscalar quarkonium produced in hadronic collisions. Relying on this, I will discuss the possibility of extracting precise information on (un)polarized gluon TMDs at a future Fixed Target Experiment at the LHC (AFTER@LHC).

  1. In vivo intra-luteal implants of prostaglandin (PG) E1 or E2 (PGE1, PGE2) prevent luteolysis in cows. II: mRNA for PGF2α, EP1, EP2, EP3 (A-D), EP3A, EP3B, EP3C, EP3D, and EP4 prostanoid receptors in luteal tissue.

    PubMed

    Weems, Yoshie S; Bridges, Phillip J; Jeoung, Myoungkun; Arreguin-Arevalo, J Alejandro; Nett, Torrance M; Vann, Rhonda C; Ford, Stephen P; Lewis, Andrew W; Neuendorff, Don A; Welsh, Thomas H; Randel, Ronald D; Weems, Charles W

    2012-01-01

    Previously, it was reported that chronic intra-uterine infusion of PGE(1) or PGE(2) every 4h inhibited luteolysis in ewes by altering luteal mRNA for luteinizing hormone (LH) receptors and unoccupied and occupied luteal LH receptors. However, estradiol-17β or PGE(2) given intra-uterine every 8h did not inhibit luteolysis in cows, but infusion of estradiol+PGE(2) inhibited luteolysis. In contrast, intra-luteal implants containing PGE(1) or PGE(2) in Angus or Brahman cows also inhibited the decline in circulating progesterone, mRNA for LH receptors, and loss of unoccupied and occupied receptors for LH to prevent luteolysis. The objective of this experiment was to determine how intra-luteal implants of PGE(1) or PGE(2) alter mRNA for prostanoid receptors and how this could influence luteolysis in Brahman or Angus cows. On day-13 Angus cows received no intra-luteal implant and corpora lutea were retrieved or Angus and Brahman cows received intra-luteal silastic implants containing Vehicle, PGE(1), or PGE(2) and corpora lutea were retrieved on day-19. Corpora lutea slices were analyzed for mRNA for prostanoid receptors (FP, EP1, EP2, EP3 (A-D), EP3A, EP3B, EP3C, EP3D, and EP4) by RT-PCR. Day-13 Angus cow luteal tissue served as pre-luteolytic controls. mRNA for FP receptors decreased in day-19 Vehicle controls compared to day-13 Vehicle controls regardless of breed. PGE(1) and PGE(2) up-regulated FP gene expression on day-19 compared to day-19 Vehicle controls regardless of breed. EP1 mRNA was not altered by any treatment. PGE(1) and PGE(2) down-regulated EP2 and EP4 mRNA compared to day-19 Vehicle controls regardless of breed. PGE(1) or PGE(2) up-regulated mRNA EP3B receptor subtype compared to day-19 Vehicle control cows regardless of breed. The similarities in relative gene expression profiles induced by PGE(1) and PGE(2) support their agonistic effects. We conclude that both PGE(1) and PGE(2) may prevent luteolysis by altering expression of mRNA for prostanoid

  2. Moisture performance analysis of EPS frost insulation

    SciTech Connect

    Ojanen, T.; Kokko, E.

    1997-11-01

    A horizontal layer of expanded polystyrene foam (EPS) is widely used as a frost insulation of building foundations in the Nordic countries. The performance properties of the insulation depend strongly on the moisture level of the material. Experimental methods are needed to produce samples for testing the material properties in realistic moisture conditions. The objective was to analyze the moisture loads and the wetting mechanisms of horizontal EPS frost insulation. Typical wetting tests, water immersion and diffusive water vapor absorption tests, were studied and the results were compared with the data from site investigations. Usually these tests give higher moisture contents of EPS than what are detected in drained frost insulation applications. Also the effect of different parameters, like the immersion depth and temperature gradient were studied. Special attention was paid to study the effect of diffusion on the wetting process. Numerical simulation showed that under real working conditions the long period diffusive moisture absorption in EPS frost insulation remained lower than 1% Vol. Moisture performance was determined experimentally as a function of the distance between the insulation and the free water level in the ground. The main moisture loads and the principles for good moisture performance of frost insulation are presented.

  3. Precision QCD measurements at HERA

    NASA Astrophysics Data System (ADS)

    Pirumov, Hayk

    2014-11-01

    A review of recent experimental results on perturbative QCD from the HERA experiments H1 and ZEUS is presented. All inclusive deep inelastic cross sections measured by the H1 and ZEUS collaborations in neutral and charged current unpolarised ep scattering are combined. They span six orders of magnitude in negative four-momentum-transfer squared, Q2, and in Bjorken x. This data set is used as the sole input to NLO and NNLO QCD analyses to determine new sets of parton distributions, HERAPDF2.0, with small experimental uncertainties and an estimate of model and parametrisation uncertainties. Also shown are new results on inclusive jet, dijet and trijet differential cross sections measured in neutral current deep inelastic scattering. The precision jet data is used to extract the strong coupling αs at NLO with small experimental errors.

  4. Impact of heavy-flavour production cross sections measured by the LHCb experiment on parton distribution functions at low x

    DOE PAGES

    Zenaiev, O.; Geiser, A.; Lipka, K.; ...

    2015-08-01

    The impact of recent measurements of heavy-flavour production in deep inelastic ep scattering and in pp collisions on parton distribution functions is studied in a QCD analysis in the fixed-flavour number scheme at next-to-leading order. Differential cross sections of charm- and beauty-hadron production measured by LHCb are used together with inclusive and heavy-flavour production cross sections in deep inelastic scattering at HERA. The heavy-flavour data of the LHCb experiment impose additional constraints on the gluon and the sea-quark distributions at low partonic fractions x of the proton momentum, down to x~5×10-6. This kinematic range is currently not covered by othermore » experimental data in perturbative QCD fits.« less

  5. Impact of heavy-flavour production cross sections measured by the LHCb experiment on parton distribution functions at low x

    SciTech Connect

    Zenaiev, O.; Geiser, A.; Lipka, K.; Blumlein, J.; Cooper-Sarkar, A.; Garzelli, M. -V.; Guzzi, M.; Kuprash, O.; Moch, S. -O.; Nadolsky, P.; Placakyte, R.; Rabbertz, K.; Schienbein, I.; Starovoitov, P.

    2015-08-01

    The impact of recent measurements of heavy-flavour production in deep inelastic ep scattering and in pp collisions on parton distribution functions is studied in a QCD analysis in the fixed-flavour number scheme at next-to-leading order. Differential cross sections of charm- and beauty-hadron production measured by LHCb are used together with inclusive and heavy-flavour production cross sections in deep inelastic scattering at HERA. The heavy-flavour data of the LHCb experiment impose additional constraints on the gluon and the sea-quark distributions at low partonic fractions x of the proton momentum, down to x~5×10-6. This kinematic range is currently not covered by other experimental data in perturbative QCD fits.

  6. 42 CFR 495.102 - Incentive payments to EPs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Incentive payments to EPs. 495.102 Section 495.102... PROGRAM Requirements Specific to the Medicare Program § 495.102 Incentive payments to EPs. (a) General...) Increase in incentive payment limit for EPs who predominantly furnish services in a geographic HPSA. In...

  7. The complete O (αs2) non-singlet heavy flavor corrections to the structure functions g1,2ep (x ,Q2), F1,2,Lep (x ,Q2), F1,2,3ν (ν bar) (x ,Q2) and the associated sum rules

    NASA Astrophysics Data System (ADS)

    Blümlein, Johannes; Falcioni, Giulio; De Freitas, Abilio

    2016-09-01

    We calculate analytically the flavor non-singlet O (αs2) massive Wilson coefficients for the inclusive neutral current non-singlet structure functions F1,2,Lep (x ,Q2) and g1,2ep (x ,Q2) and charged current non-singlet structure functions F1,2,3ν (ν bar) p (x ,Q2), at general virtualities Q2 in the deep-inelastic region. Numerical results are presented. We illustrate the transition from low to large virtualities for these observables, which may be contrasted to basic assumptions made in the so-called variable flavor number scheme. We also derive the corresponding results for the Adler sum rule, the unpolarized and polarized Bjorken sum rules and the Gross-Llewellyn Smith sum rule. There are no logarithmic corrections at large scales Q2 and the effects of the power corrections due to the heavy quark mass are of the size of the known O (αs4) corrections in the case of the sum rules. The complete charm and bottom corrections are compared to the approach using asymptotic representations in the region Q2 ≫mc,b2. We also study the target mass corrections to the above sum rules.

  8. EPS analysis of nominal STS-1 flight

    NASA Technical Reports Server (NTRS)

    Wolfgram, D. F.; Pipher, M. D.

    1980-01-01

    The results of electrical power system (EPS) analysis of the planned Shuttle Transportation System Flight 1 mission are presented. The capability of the orbiter EPS to support the planned flight and to provide program tape information and supplementary data specifically requested by the flight operations directorate was assessed. The analysis was accomplished using the orbiter version of the spacecraft electrical power simulator program, operating from a modified version of orbiter electrical equipment utilization baseline revision four. The results indicate that the nominal flight, as analyzed, is within the capabilities of the orbiter power generation system, but that a brief, and minimal, current overload may exist between main distributor 1 and mid power controlled 1, and that inverter 9 may the overloaded for extended periods of time. A comparison of results with launch commit criteria also indicated that some of the presently existing launch redlines may be violated during the terminal countdown.

  9. Regulation of prostaglandin EP1 and EP4 receptor signaling by carrier-mediated ligand reuptake

    PubMed Central

    Chi, Yuling; Suadicani, Sylvia O; Schuster, Victor L

    2014-01-01

    After synthesis and release from cells, prostaglandin E2 (PGE2) undergoes reuptake by the prostaglandin transporter (PGT), followed by cytoplasmic oxidation. Although genetic inactivation of PGT in mice and humans results in distinctive phenotypes, and although experiments in localized environments show that manipulating PGT alters downstream cellular events, a direct mechanistic link between PGT activity and PGE2 (EP) receptor activation has not been made. Toward this end, we created two reconstituted systems to examine the effect of PGT expression on PGE2 signaling via two of its receptors (EP1 and EP4). In human embryonic kidney cells engineered to express the EP1 receptor, exogenous PGE2 induced a dose-dependent increase in cytoplasmic Ca2+. When PGT was expressed at the plasma membrane, the PGE2 dose–response curve was right-shifted, consistent with reduction in cell surface PGE2 availability; a potent PGT inhibitor acutely reversed this shift. When bradykinin was used to induce endogenous PGE2 release, PGT expression similarly induced a reduction in Ca2+ responses. In separate experiments using Madin–Darby Canine Kidney cells engineered to express the PGE2 receptor EP4, bradykinin again induced autocrine PGE2 signaling, as judged by an abrupt increase in intracellular cAMP. As in the EP1 experiments, expression of PGT at the plasma membrane caused a reduction in bradykinin-induced cAMP accumulation. Pharmacological concentrations of exogenous PGE2 induced EP4 receptor desensitization, an effect that was mitigated by PGT. Thus, at an autocrine/paracrine level, plasma membrane PGT regulates PGE2 signaling by decreasing ligand availability at cell surface receptors. PMID:25505603

  10. Hard exclusive neutral pion production at Jefferson Lab Hall A

    SciTech Connect

    E. Fuchey

    2011-10-01

    We present measurements of the ep {yields} ep{pi}{sup 0} cross section extracted at two values of four-momentum transfer Q{sup 2} = 1.9 GeV{sup 2} and Q{sup 2} = 2.3 GeV{sup 2} at Jefferson Lab Hall A. The kinematic range allows to study the evolution of the cross section as a function of Q{sup 2} and W. Results will be confronted with Regge inspired calculations and GPD predictions. An interpretation of our data within the framework of semi-inclusive deep inelastic scattering has also been attempted.

  11. Exclusive Neutral Pion Electroproduction in the Deeply Virtual Regime

    SciTech Connect

    Fuchey, E; Camsonne, A; Mazouz, M; Gavalian, G; Kuchina, E; Amarian, M; Aniol, K A; Beaumel, M; Benaoum, H; Bertin, P; Brossard, M; Canan, M; Chen, J -P; Chudakov, E; Craver, B; Cusanno, F; de Jager, C W; Deur, A; Ferdi, C; Feuerbach, R; Fieschi, J -M; Frullani, S; Garcon, M; Garibaldi, F; Gayou, O; Gilman, R; Gomez, J; Gueye, P; Guichon, P.A.M.; Guillon, B; Hansen, O; Hayes, D; Higinbotham, D W; Homstrom, T; Hyde, C E; Ibrahim, H; Igarashi, R; Itard, F; Jiang, X; Jo, H S; Kaufman, L J; Kelleher, A; Kolarkar, A; Kumbartzki, G; Laveissiere, G; LeRose, J J; Lindgren, R; Liyanage, N; Lu, H -J; Margaziotis, D J; Meziani, Z -E; McCormick, K; Michaels, R; Michel, B; Moffit, B; Monaghan, P; Nanda, S; Nelyubin, V; Potokar, M; Qiang, Y; Ransome, R D; Real, J -S; Reitz, B; Roblin, Y; Roche, J; Sabatie, F; Saha, A; Sirca, S; Slifer, K; Solvignon, P; Subedi, R; Sulkosky, V; Ulmer, P E; Voutier, E; Wang, K; Weinstein, L B; Wojtsekhowski, B; Zheng, X; Zhu, L

    2011-02-01

    We present measurements of the ep->ep pi^0 cross section extracted at two values of four-momentum transfer Q^2=1.9 GeV^2 and Q^2=2.3 GeV^2 at Jefferson Lab Hall A. The kinematic range allows to study the evolution of the extracted hadronic tensor as a function of Q^2 and W. Results will be confronted with Regge inspired calculations and GPD predictions. An intepretation of our data within the framework of semi-inclusive deep inelastic scattering has also been attempted.

  12. Exclusive neutral pion electroproduction in the deeply virtual regime

    SciTech Connect

    Fuchey, E.; Camsonne, A.; Bertin, P.; Munoz Camacho, C.; Gavalian, G.; Amarian, M.; Canan, M.; Hayes, D.; Ibrahim, H.; Ulmer, P. E.; Weinstein, L. B.; Kuchina, E.; Gilman, R.; Jiang, X.; Kumbartzki, G.; McCormick, K.; Ransome, R. D.; Aniol, K. A.; Margaziotis, D. J.

    2011-02-15

    We present measurements of the ep{yields}ep{pi}{sup 0} cross section extracted at two values of four-momentum transfer Q{sup 2}=1.9 GeV{sup 2} and Q{sup 2}=2.3 GeV{sup 2} at Jefferson Lab Hall A. The kinematic range allows one to study the evolution of the extracted cross section as a function of Q{sup 2} and W. Results are confronted with Regge-inspired calculations and GPD predictions. An intepretation of our data within the framework of semi-inclusive deep inelastic scattering is also discussed.

  13. Hard exclusive neutral pion production at Jefferson Lab Hall A

    SciTech Connect

    Fuchey, E.

    2011-10-24

    We present measurements of the ep{yields}ep{pi}{sup 0} cross section extracted at two values of four-momentum transfer Q{sup 2} = 1.9 GeV{sup 2} and Q{sup 2} = 2.3 GeV{sup 2} at Jefferson Lab Hall A. The kinematic range allows to study the evolution of the cross section as a function of Q{sup 2} and W. Results will be confronted with Regge inspired calculations and GPD predictions. An intepretation of our data within the framework of semi-inclusive deep inelastic scattering has also been attempted.

  14. Lead Optimization Studies of Cinnamic Amide EP2 Antagonists

    PubMed Central

    2015-01-01

    Prostanoid receptor EP2 can play a proinflammatory role, exacerbating disease pathology in a variety of central nervous system and peripheral diseases. A highly selective EP2 antagonist could be useful as a drug to mitigate the inflammatory consequences of EP2 activation. We recently identified a cinnamic amide class of EP2 antagonists. The lead compound in this class (5d) displays anti-inflammatory and neuroprotective actions. However, this compound exhibited moderate selectivity to EP2 over the DP1 prostanoid receptor (∼10-fold) and low aqueous solubility. We now report compounds that display up to 180-fold selectivity against DP1 and up to 9-fold higher aqueous solubility than our previous lead. The newly developed compounds also display higher selectivity against EP4 and IP receptors and a comparable plasma pharmacokinetics. Thus, these compounds are useful for proof of concept studies in a variety of models where EP2 activation is playing a deleterious role. PMID:24773616

  15. Redox properties of extracellular polymeric substances (EPS) from electroactive bacteria

    NASA Astrophysics Data System (ADS)

    Li, Shan-Wei; Sheng, Guo-Ping; Cheng, Yuan-Yuan; Yu, Han-Qing

    2016-12-01

    Although the capacity for electroactive bacteria to convert environmental metallic minerals and organic pollutants is well known, the role of the redox properties of microbial extracellular polymeric substances (EPS) in this process is poorly understood. In this work, the redox properties of EPS from two widely present electroactive bacterial strains (Shewanella oneidensis and Pseudomonas putida) were explored. Electrochemical analysis demonstrates that the EPS extracted from the two strains exhibited redox properties. Spectroelectrochemical and protein electrophoresis analyses indicate that the extracted EPS from S. oneidensis and P. putida contained heme-binding proteins, which were identified as the possible redox components in the EPS. The results of heme-mediated behavior of EPS may provide an insight into the important roles of EPS in electroactive bacteria to maximize their redox capability for biogeochemical cycling, environmental bioremediation and wastewater treatment.

  16. Lead optimization studies of cinnamic amide EP2 antagonists.

    PubMed

    Ganesh, Thota; Jiang, Jianxiong; Yang, Myung-Soon; Dingledine, Ray

    2014-05-22

    Prostanoid receptor EP2 can play a proinflammatory role, exacerbating disease pathology in a variety of central nervous system and peripheral diseases. A highly selective EP2 antagonist could be useful as a drug to mitigate the inflammatory consequences of EP2 activation. We recently identified a cinnamic amide class of EP2 antagonists. The lead compound in this class (5d) displays anti-inflammatory and neuroprotective actions. However, this compound exhibited moderate selectivity to EP2 over the DP1 prostanoid receptor (∼10-fold) and low aqueous solubility. We now report compounds that display up to 180-fold selectivity against DP1 and up to 9-fold higher aqueous solubility than our previous lead. The newly developed compounds also display higher selectivity against EP4 and IP receptors and a comparable plasma pharmacokinetics. Thus, these compounds are useful for proof of concept studies in a variety of models where EP2 activation is playing a deleterious role.

  17. Redox properties of extracellular polymeric substances (EPS) from electroactive bacteria

    PubMed Central

    Li, Shan-Wei; Sheng, Guo-Ping; Cheng, Yuan-Yuan; Yu, Han-Qing

    2016-01-01

    Although the capacity for electroactive bacteria to convert environmental metallic minerals and organic pollutants is well known, the role of the redox properties of microbial extracellular polymeric substances (EPS) in this process is poorly understood. In this work, the redox properties of EPS from two widely present electroactive bacterial strains (Shewanella oneidensis and Pseudomonas putida) were explored. Electrochemical analysis demonstrates that the EPS extracted from the two strains exhibited redox properties. Spectroelectrochemical and protein electrophoresis analyses indicate that the extracted EPS from S. oneidensis and P. putida contained heme-binding proteins, which were identified as the possible redox components in the EPS. The results of heme-mediated behavior of EPS may provide an insight into the important roles of EPS in electroactive bacteria to maximize their redox capability for biogeochemical cycling, environmental bioremediation and wastewater treatment. PMID:27991531

  18. Development of the nuclear weapons complex EP architecture

    SciTech Connect

    Murray, C.; Halbleib, L.

    1996-07-01

    The Nuclear Weapons Guidance Team is an interagency committee led by Earl Whiteman, DOE that chartered the generation of EP40100, Concurrent Qualification and its successor EP401099, Concurrent Engineering and Qualification. As this new philosophy of concurrent operations has evolved and as implementation has been initiated, conflicts and insufficiencies in the remaining Engineering Procedures (EPs) have become more apparent. At the Guidance Team meeting in November 1995, this issue was explored and several approaches were considered. It was concluded at this meeting, that a smaller set of interagency EPs described in a hierarchical system could provide the necessary interagency direction to support complex-wide implementation. This set consolidates many existing EP processes where consistency and commonality are critical to success of the extended enterprise. The Guidance Team subsequently chartered an interagency team to initiate development activity associated with the envisioned new EP set. This team had participation from seven Nuclear Weapons Complex (NWC) sites as well as DOE/AL and DP-14 (team members are acknowledged later in this report). Per the Guidance Team, this team, referred to as the Architecture Subcommittee, was to map out and define an EP Architecture for the interagency EPs, make recommendations regarding a more agile process for EP approval and suggest an aggressive timeline to develop the combined EPs. The Architecture Subcommittee was asked to brief their output at the February Guidance Team meeting. This SAND report documents the results of the Architecture Subcommittee`s recommendations.

  19. Experimental search for two-hard-photon exchange in elastic ep experiments

    SciTech Connect

    Charles Perdrisat

    2012-09-01

    A remarkable change of paradigm was precipitated by the results, obtained in the last 12 years, of new measurements of the proton form factor ratio; the two form factors, G{sub Ep} and G{sub Mp}, are not in a constant ratio, as had been concluded from previous cross section experiments, and would be the case if charge and magnetization spatial distributions were the same. Rather, as the series of polarization measurements at JLab shows, the ratio {mu}{sub p}G{sub Ep}/G{sub Mp} decreases smoothly from 1 at Q{sup 2} = 0, to about 0.15 at Q{sup 2} = 8.5 GeV{sup 2}, with Q{sup 2} the negative of the four-momentum transfer squared. The interesting question is then: how can the results using two methods both related through the Born approximation, be found to lead to a different form factor ratio? The short answer is that cross sections require large radiative corrections, which tend to mask G{sub Ep} for increasing Q{sup 2}, whereas recoil polarization experiments measure the ratio of two components of the recoil polarization, which tends to cancel the effect of radiative corrections. Radiative corrections to the cross section of ep scattering have a long history. They may just not be accurate enough when the ratio G{sub Ep}/G{sub Mp} {approx} 0.05 and {tau} = Q{sup 2}/4m{sub p}{sup 2} {approx} 2.5, as is the case for the largest Q{sup 2} for which we have double-polarization data, 8.5 GeV{sup 2}. For this Q{sup 2} and with the Born cross section given by d{sigma} {approx} G{sub Ep}{sup 2} + ({tau}/{var_epsilon})G{sub Mp}{sup 2}, with {var_epsilon} the kinematic factor, the contribution to the cross section of G{sub Ep} becomes smaller than 0.1%, i.e. non-measurable in cross section experiments. The other hypothesis, is that the radiative corrections are incomplete, and that the exchange of two hard photons is the source of the discrepancy; the idea has been pursued in numerous works, but to this day there is no direct, experimental evidence that two

  20. Rooting gene trees without outgroups: EP rooting.

    PubMed

    Sinsheimer, Janet S; Little, Roderick J A; Lake, James A

    2012-01-01

    Gene sequences are routinely used to determine the topologies of unrooted phylogenetic trees, but many of the most important questions in evolution require knowing both the topologies and the roots of trees. However, general algorithms for calculating rooted trees from gene and genomic sequences in the absence of gene paralogs are few. Using the principles of evolutionary parsimony (EP) (Lake JA. 1987a. A rate-independent technique for analysis of nucleic acid sequences: evolutionary parsimony. Mol Biol Evol. 4:167-181) and its extensions (Cavender, J. 1989. Mechanized derivation of linear invariants. Mol Biol Evol. 6:301-316; Nguyen T, Speed TP. 1992. A derivation of all linear invariants for a nonbalanced transversion model. J Mol Evol. 35:60-76), we explicitly enumerate all linear invariants that solely contain rooting information and derive algorithms for rooting gene trees directly from gene and genomic sequences. These new EP linear rooting invariants allow one to determine rooted trees, even in the complete absence of outgroups and gene paralogs. EP rooting invariants are explicitly derived for three taxon trees, and rules for their extension to four or more taxa are provided. The method is demonstrated using 18S ribosomal DNA to illustrate how the new animal phylogeny (Aguinaldo AMA et al. 1997. Evidence for a clade of nematodes, arthropods, and other moulting animals. Nature 387:489-493; Lake JA. 1990. Origin of the metazoa. Proc Natl Acad Sci USA 87:763-766) may be rooted directly from sequences, even when they are short and paralogs are unavailable. These results are consistent with the current root (Philippe H et al. 2011. Acoelomorph flatworms are deuterostomes related to Xenoturbella. Nature 470:255-260).

  1. Strain hardening of steel EP836

    SciTech Connect

    Lyadskaya, A.A.; Lappa, R.M.; Spuskanyuk, V.Z.

    1986-03-01

    The authors investigate the effect of different combinations of cold hydraulic pressing and heat treatment on the physical and mechanical properties of steel EP836 (03N17K10V10MT), containing 0.03% C, 16-17% Ni, 10-11.5% Co, 9.5-11.5% W, 1% Ti, 1% Mo, and 0.15% A1. Deformation of the unaged steel resulted in insignificant hardening without a decrease in plasticity; this agrees with the results of investigations of other steels of this class.

  2. Rayleigh Scattering.

    ERIC Educational Resources Information Center

    Young, Andrew T.

    1982-01-01

    The correct usage of such terminology as "Rayleigh scattering,""Rayleigh lines,""Raman lines," and "Tyndall scattering" is resolved during an historical excursion through the physics of light-scattering by gas molecules. (Author/JN)

  3. Overview of microalgal extracellular polymeric substances (EPS) and their applications.

    PubMed

    Xiao, Rui; Zheng, Yi

    2016-11-15

    Microalgae have been studied as natural resources for a number of applications, most particularly food, animal feed, biofuels, pharmaceuticals, and nutraceuticals. In addition to the intracellular compounds of interest, microalgae can also excrete various extracellular polymeric substances (EPS) into their immediate living environment during their life cycle to form a hydrated biofilm matrix. These microalgal EPS mainly consist of polysaccharides, proteins, nucleic acids and lipids. Most notably, EPS retain their stable matrix structure and form a 3-D polymer network for cells to interact with each other, and mediate their adhesion to surfaces. EPS also play a role as extracellular energy and carbon sinks. They are also abundant source of structurally and compositionally diverse biopolymers which possess unique bioactivities for special high-value applications, specifically as antivirals, antitumor agents, antioxidants, anticoagulants and anti-inflammatories. Their superior rheological properties also make microalgal EPS particularly useful in mechanical engineering (e.g., biolubricants and drag reducers) and food science/engineering (e.g., thickener and preservatives) applications. The chemical composition and structure of EPS appear to correlate with their applications, but the fundamentals of such relationship are not well understood. This article summarizes previous research on microalgal EPS derived from green algae, diatoms and red algae, including compositions/functions/structure, production, and potential applications. The importance of exopolysaccharides and EPS proteins, with their particular metabolic characteristics, are also described because of their potential high-value applications. This review concludes with potential future research areas of microalgal EPS.

  4. Determination of the angular and energy dependence of hard constituent scattering from. pi. /sup 0/ pair events at the CERN intersecting storage rings

    SciTech Connect

    Angelis, A.L.S.; Besch, H.J.; Blumenfeld, B.J.

    1982-08-23

    We present data on proton-proton collisions, obtained at the CERN Intersecting Storage Rings, in which two roughly back-to-back ..pi../sup 0/'s of high transverse momentum (p/sub T/) were produced. The angular distribution of the dipion axis relative to the collision axis is found to be independent of both the effective mass m of the dipion system and the centre-of-mass energy ..sqrt..s of the proton-proton collision. The cross-sections dsigma/dm at the two values of ..sqrt..s satisfy a scaling law of the form dsigma/dm = G(x)/m/sup n/, where x = m(..pi../sup 0/,..pi../sup 0/)/..sqrt..s and n = 6.5 +- 0.5. We show from our data that the leading ..pi../sup 0/ carries most of the momentum of the scattered parton. Given this fact, the axis of the dipion system follows closely the direction of the scattered constituents, and we exploit this to determine the angular dependence of the hard-scattering subprocess. We also compare our data with the lowest order QCD predictions using structure functions as determined in deep-inelastic scattering and fragmentation functions from electron-positron annihilation.

  5. EPS-SJ Exopolisaccharide Produced by the Strain Lactobacillus paracasei subsp. paracasei BGSJ2-8 Is Involved in Adhesion to Epithelial Intestinal Cells and Decrease on E. coli Association to Caco-2 Cells

    PubMed Central

    Živković, Milica; Miljković, Marija S.; Ruas-Madiedo, Patricia; Markelić, Milica B.; Veljović, Katarina; Tolinački, Maja; Soković, Svetlana; Korać, Aleksandra; Golić, Nataša

    2016-01-01

    The aim of this study was to determine the role of an exopolysaccharide produced by natural dairy isolate Lactobacillus paracasei subsp. paracasei BGSJ2-8, in the adhesion to intestinal epithelial cells and a decrease in Escherichia coli’s association with Caco-2 cells. Annotation of the BGSJ2-8 genome showed the presence of a gene cluster, epsSJ, which encodes the biosynthesis of the strain-specific exopolysaccharide EPS-SJ, detected as two fractions (P1 and P2) by size exclusion chromatography (SEC) coupled with multi-angle laser light scattering (MALLS) detection. SEC-MALLS analysis revealed that an EPS-SJ- mutant (EPS7, obtained by insertion mutagenesis of the glps_2198 gene encoding primary glycosyltransferase) does not produce the P2 fraction of EPS-SJ. Transmission electron microscopy showed that EPS7 mutant has a thinner cell wall compared to the EPS-SJ+ strain BGSJ2-83 (a plasmid free-derivative of BGSJ2-8). Interestingly, strain BGSJ2-83 showed higher adhesion to Caco-2 epithelial intestinal cell line than the EPS7 mutant. Accordingly, BGSJ2-83 effectively reduced E. coli ATCC25922’s association with Caco-2 cells, while EPS7 did not show statistically significant differences. In addition, the effect of EPS-SJ on the proliferation of lymphocytes in gastrointestinal associated lymphoid tissue (GALT) was tested and the results showed that the reduction of GALT lymphocyte proliferation was higher by BGSJ2-83 than by the mutant. To the best of our knowledge this is the first report indicating that the presence of EPS (EPS-SJ) on the surface of lactobacilli can improve communication between bacteria and intestinal epithelium, implying its possible role in gut colonization. PMID:27014210

  6. EPS-SJ Exopolisaccharide Produced by the Strain Lactobacillus paracasei subsp. paracasei BGSJ2-8 Is Involved in Adhesion to Epithelial Intestinal Cells and Decrease on E. coli Association to Caco-2 Cells.

    PubMed

    Živković, Milica; Miljković, Marija S; Ruas-Madiedo, Patricia; Markelić, Milica B; Veljović, Katarina; Tolinački, Maja; Soković, Svetlana; Korać, Aleksandra; Golić, Nataša

    2016-01-01

    The aim of this study was to determine the role of an exopolysaccharide produced by natural dairy isolate Lactobacillus paracasei subsp. paracasei BGSJ2-8, in the adhesion to intestinal epithelial cells and a decrease in Escherichia coli's association with Caco-2 cells. Annotation of the BGSJ2-8 genome showed the presence of a gene cluster, epsSJ, which encodes the biosynthesis of the strain-specific exopolysaccharide EPS-SJ, detected as two fractions (P1 and P2) by size exclusion chromatography (SEC) coupled with multi-angle laser light scattering (MALLS) detection. SEC-MALLS analysis revealed that an EPS-SJ(-) mutant (EPS7, obtained by insertion mutagenesis of the glps_2198 gene encoding primary glycosyltransferase) does not produce the P2 fraction of EPS-SJ. Transmission electron microscopy showed that EPS7 mutant has a thinner cell wall compared to the EPS-SJ(+) strain BGSJ2-83 (a plasmid free-derivative of BGSJ2-8). Interestingly, strain BGSJ2-83 showed higher adhesion to Caco-2 epithelial intestinal cell line than the EPS7 mutant. Accordingly, BGSJ2-83 effectively reduced E. coli ATCC25922's association with Caco-2 cells, while EPS7 did not show statistically significant differences. In addition, the effect of EPS-SJ on the proliferation of lymphocytes in gastrointestinal associated lymphoid tissue (GALT) was tested and the results showed that the reduction of GALT lymphocyte proliferation was higher by BGSJ2-83 than by the mutant. To the best of our knowledge this is the first report indicating that the presence of EPS (EPS-SJ) on the surface of lactobacilli can improve communication between bacteria and intestinal epithelium, implying its possible role in gut colonization.

  7. The Recovery of TOMS-EP

    NASA Technical Reports Server (NTRS)

    Robertson, Brent; Sabelhaus, Phil; Mendenhall, Todd; Fesq, Lorraine

    1998-01-01

    On December 13th 1998, the Total Ozone Mapping Spectrometer - Earth Probe (TOMS-EP) spacecraft experienced a Single Event Upset which caused the system to reconfigure and enter a Safe Mode. This incident occurred two and a half years after the launch of the spacecraft which was designed for a two year life. A combination of factors, including changes in component behavior due to age and extended use, very unfortunate initial conditions and the safe mode processing logic prevented the spacecraft from entering its nominal long term storage mode. The spacecraft remained in a high fuel consumption mode designed for temporary use. By the time the onboard fuel was exhausted, the spacecraft was Sun pointing in a high rate flat spin. Although the uncontrolled spacecraft was initially in a power and thermal safe orientation, it would not stay in this state indefinitely due to a slow precession of its momentum vector. A recovery team was immediately assembled to determine if there was time to develop a method of despinning the vehicle and return it to normal science data collection. A three stage plan was developed that used the onboard magnetic torque rods as actuators. The first stage was designed to reduce the high spin rate to within the linear range of the gyros. The second stage transitioned the spacecraft from sun pointing to orbit reference pointing. The final stage returned the spacecraft to normal science operation. The entire recovery scenario was simulated with a wide range of initial conditions to establish the expected behavior. The recovery sequence was started on December 28th 1998 and completed by December 31st. TOMS-EP was successfully returned to science operations by the beginning of 1999. This paper describes the TOMS-EP Safe Mode design and the factors which led to the spacecraft anomaly and loss of fuel. The recovery and simulation efforts are described. Flight data are presented which show the performance of the spacecraft during its return to science

  8. Selected engineering properties and applications of EPS geofoam

    NASA Astrophysics Data System (ADS)

    Elragi, Ahmed Fouad

    Expanded polystyrene (EPS) geofoam is a lightweight material that has been used in engineering applications since at least the 1950s. Its density is about a hundredth of that of soil. It has good thermal insulation properties with stiffness and compression strength comparable to medium clay. It is utilized in reducing settlement below embankments, sound and vibration damping, reducing lateral pressure on substructures, reducing stresses on rigid buried conduits and related applications. This study starts with an overview on EPS geofoam. EPS manufacturing processes are described followed by a review of engineering properties found in previous research work done so far. Standards and design manuals applicable to EPS are presented. Selected EPS geofoam-engineering applications are discussed with examples. State-of-the-art of experimental work is done on different sizes of EPS specimens under different loading rates for better understanding of the behavior of the material. The effects of creep, sample size, strain rate and cyclic loading on the stress strain response are studied. Equations for the initial modulus and the strength of the material under compression for different strain rates are presented. The initial modulus and Poisson's ratio are discussed in detail. Sample size effect on creep behavior is examined. Three EPS projects are shown in this study. The creep behavior of the largest EPS geofoam embankment fill is shown. Results from laboratory tests, mathematical modeling and field records are compared to each other. Field records of a geofoam-stabilized slope are compared to finite difference analysis results. Lateral stress reduction on an EPS backfill retaining structure is analyzed. The study ends with a discussion on two promising properties of EPS geofoam. These are the damping ability and the compressibility of this material. Finite element analysis, finite difference analysis and lab results are included in this discussion. The discussion with the

  9. Proton Magnetic Form Factor from Existing Elastic e-p Cross Section Data

    NASA Astrophysics Data System (ADS)

    Ou, Longwu; Christy, Eric; Gilad, Shalev; Keppel, Cynthia; Schmookler, Barak; Wojtsekhowski, Bogdan

    2015-04-01

    The proton magnetic form factor GMp, in addition to being an important benchmark for all cross section measurements in hadron physics, provides critical information on proton structure. Extraction of GMp from e-p cross section data is complicated by two-photon exchange (TPE) effects, where available calculations still have large theoretical uncertainties. Studies of TPE contributions to e-p scattering have observed no nonlinear effects in Rosenbluth separations. Recent theoretical investigations show that the TPE correction goes to 0 when ɛ approaches 1, where ɛ is the virtual photon polarization parameter. In this talk, existing e-p elastic cross section data are reanalyzed by extrapolating the reduced cross section for ɛ approaching 1. Existing polarization transfer data, which is supposed to be relatively immune to TPE effects, are used to produce a ratio of electric and magnetic form factors. The extrapolated reduced cross section and polarization transfer ratio are then used to calculate GEp and GMp at different Q2 values.

  10. EP Additive Performance in Biobased vs. Paraffinic Base Oils

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A series of commercial extreme pressure (EP) additives containing sulfur, phosphorus, and chlorine were investigated for their EP properties in soybean (SBO) and paraffinic (PRFN) base oils. The investigations were conducted using a 4-ball (4B) and twist-compression (TC) tribometers. The concentra...

  11. Spacecraft Electrical Power System (EPS) generic analysis tools and techniques

    NASA Technical Reports Server (NTRS)

    Morris, Gladys M.; Sheppard, Mark A.

    1992-01-01

    An overview is provided of the analysis tools and techiques used in modeling the Space Station Freedom electrical power system, as well as future space vehicle power systems. The analysis capabilities of the Electrical Power System (EPS) are described and the EPS analysis tools are surveyed.

  12. Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists.

    PubMed

    Ganesh, Thota; Jiang, Jianxiong; Shashidharamurthy, Rangaiah; Dingledine, Ray

    2013-07-11

    Prostanoid receptor EP2 is emerging as a novel target for development of anti-inflammatory drugs for the treatment of chronic neurodegenerative and peripheral diseases; however, the availability of EP2 antagonist probes for exploration of peripheral disease models is very limited. We now report identification and characterization of a novel chemical class of compounds that show nanomolar potency and competitive antagonism of the EP2 receptor. A compound in this class, TG6-129, showed prolonged plasma half-life and did not cross the blood brain barrier. This compound also suppressed the induction of inflammatory mRNA markers in a macrophage cell line upon activation of EP2. Thus, this compound could be useful as a probe for a variety of peripheral chronic inflammatory diseases such as rheumatoid arthritis and chronic obstructive pulmonary disease, in which EP2 appears to play a pathogenic role.

  13. Discovery of G Protein-Biased EP2 Receptor Agonists

    PubMed Central

    2016-01-01

    To identify G protein-biased and highly subtype-selective EP2 receptor agonists, a series of bicyclic prostaglandin analogues were designed and synthesized. Structural hybridization of EP2/4 dual agonist 5 and prostacyclin analogue 6, followed by simplification of the ω chain enabled us to discover novel EP2 agonists with a unique prostacyclin-like scaffold. Further optimization of the ω chain was performed to improve EP2 agonist activity and subtype selectivity. Phenoxy derivative 18a showed potent agonist activity and excellent subtype selectivity. Furthermore, a series of compounds were identified as G protein-biased EP2 receptor agonists. These are the first examples of biased ligands of prostanoid receptors. PMID:26985320

  14. Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines.

    PubMed

    Okuyama, T; Ishihara, S; Sato, H; Rumi, M A K; Kawashima, K; Miyaoka, Y; Suetsugu, H; Kazumori, H; Cava, C F Ortega; Kadowaki, Y; Fukuda, R; Kinoshita, Y

    2002-08-01

    The effect of prostaglandin E2 (PGE2) on the proliferation of gastric cancer cells is still unclear. PGE2 receptors are divided into four subtypes - EP1, EP2, EP3, and EP4 - which are coupled to three different intracellular signal-transduction systems. Stimulation of EP2 and EP4 is linked with cyclic adenosine 3', 5'-monophosphate (cAMP)-dependent protein kinase A (PKA). In some human gastric cancer cells, PGE2 has been suggested to have an antiproliferative effect by way of increased cAMP production. Expression of EP2 and EP4 in human gastric carcinoma cells, however, has not been examined. We examined the expression of EP2 and EP4 and the antiproliferative effects of specific EP2 and EP4 agonists on four different human gastric cancer cell lines. Our data clarified that all the cell lines investigated in this study expressed EP2 and EP4 and that the specific agonists of these receptors induced growth inhibition with an accompanying increase in cAMP production. In summary, gastric cancer cells have EP2 and EP4 receptors, and their selective activation is linked with the decreased cell proliferation.

  15. Anorexia and cachexia in prostaglandin EP1 and EP3 subtype receptor knockout mice bearing a tumor with high intrinsic PGE2 production and prostaglandin related cachexia.

    PubMed

    Wang, W; Andersson, M; Lönnroth, C; Svanberg, E; Lundholm, K

    2005-03-01

    Previous studies in our laboratory have suggested that prostaglandin (PG) E2 is involved in anorexia/cachexia development in MCG 101 tumor-bearing mice. However, the role of COX pathways in the pathogenesis of cancer anorexia/cachexia is not fully resolved. In the present study, we investigated the role of PGE receptors subtype EP1 and EP3 on the development of anorexia in MCG 101-bearing mice. Our results show that the absence of host EP1 or EP3 receptors did not alter the magnitude of anorexia in tumor-bearers. However, anorexia in tumor-bearing EP1 and EP3 knockouts was not improved by indomethacin treatment as observed in wild type tumor-bearers. By contrast, indomethacin improved body composition similar in EP1 and EP3 knockouts as well as in wild type tumor-bearing animals and tumor growth was retarded in EP1 and promoted in EP3 knock outs. Our results demonstrate that host EP1 and EP3 receptors are involved in the control of local tumor growth, which translates into anorexia, this being the main cause of metabolic adaptive alterations to explain weight loss in this model. Brain EP1 and EP3 subtype receptors do not seem to directly control anorexia, which leaves EP2 and EP4 as potential candidates.

  16. Adhesion of Bacterial EPS to Goethite and Silica Surfaces

    NASA Astrophysics Data System (ADS)

    Chorover, J.; Omoike, A.

    2003-12-01

    Bacterial adhesion to mineral surfaces is mediated by cell surface macromolecules including lipopolysaccharides, lipoteichoic acids, surface proteins and extracellular polymeric substances (EPS). EPS, a heterogeneous mixture of polysaccharides, proteins and nucleic acids that occur in both cell-bound (capsular) and free form, are thought to mediate cell adhesion through modification of cell surface chemistry and formation of conditioning films, but molecular-scale interactions are not well known. We isolated EPS from the exponential and stationary growth phases of Bacillus subtilis, a common soil bacterium, and characterized them using spectroscopy (XPS, FTIR, NMR) and high pressure size exclusion chromatography (HPSEC). Attenuated total reflectance (ATR)- FTIR was employed to probe EPS adsorption from aqueous solution to goethite and amorphous silica colloids that were coated onto a Ge internal reflectance element. Relative intensity of IR bands characteristic of protein, polysaccharides and nucleic acids were dependent on growth phase and type of EPS (free or cell-bound). Proton complexation at acidic functional groups resulted in protein conformational changes; alpha-helical conformation was observed at pH < 4 and random coil (unordered) conformation at pH > 6. The apparent molecular mass estimated by HPSEC ranged from 0.42-132 kDa and peak elution times exhibited significant dependence on aqueous chemistry reflecting changes in conformation. EPS exhibited higher affinity for goethite than for silica but sorption to both solids resulted in molecular changes that were detectable by FTIR. We observed an increase in amide II band intensity and an amide I band shift to higher wavenumbers, suggesting changes in EPS secondary structure of proteins upon adsorption. Silica-sorbed EPS exhibited weak polysaccharide bands whereas sorption to goethite showed polysaccharide fractionation. Distinct spectral features indicative of the formation of P-O-Fe bonds were observed in

  17. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α

    PubMed Central

    Kuan, I.-I.; Liang, Kang-Hao; Wang, Yi-Ping; Kuo, Ting-Wen; Meir, Yaa-Jyuhn James; Wu, Sareina Chiung-Yuan; Yang, Shang-Chih; Lu, Jean; Wu, Han-Chung

    2017-01-01

    Epithelial cell adhesion molecule (EpCAM) was reported to be cleaved into extracellular domain of EpCAM (EpEX) and intracellular domain of EpCAM (EpICD). We previously reported that EpCAM serves as a potent stem cell marker which is highly and selectively expressed by undifferentiated rather than differentiated hESC. However, the functional role of EpCAM remains elusive. Here, we found that EpEX and EpCAM enhance the efficiency of OSKM reprogramming. Interestingly, Oct4 or Klf4 alone, but not Sox2, can successfully reprogram fibroblasts into iPSCs with EpEX and EpCAM. Moreover, EpEX and EpCAM trigger reprogramming via activation of STAT3, which leads to the nuclear-translocation of HIF2α. This study reveals the importance of a novel EpEX/EpCAM-STAT3-HIF2α signal in the reprogramming process, and uncovers a new means of triggering reprogramming by delivery of soluble and transmembrane proteins. PMID:28157205

  18. Microbial extracellular polymeric substances (EPS) in fresh water sediments.

    PubMed

    Gerbersdorf, Sabine Ulrike; Westrich, Bernhard; Paterson, David M

    2009-08-01

    Microbially produced extracellular polymeric substances (EPS) have been linked with many important ecological functions in natural sediments; yet, most information has been derived from marine systems. The present paper is the first comprehensive study on EPS (i.e., carbohydrates and proteins) dynamics in riverine sediments addressing spatial (six reservoirs and four groyne fields across three European rivers), temporal (all seasons in 2003-2005), and vertical (over a 50-cm sediment depth transect) pattern. The variation in hydrodynamic regime found in the reservoirs and groyne fields was reflected in the biomass and composition of the benthic microorganisms that produce EPS. The microphytobenthic communities consisted mainly of diatoms and a higher algal biomass (up to 248 microg g(-1) dry weight, DW) seemed to be indicative for higher amounts of secreted colloidal carbohydrates. Consequently, the model proposed by Underwood and Smith (1998) for the relation chlorophyll-colloidal carbohydrates was also applicable for upper riverine sediment layers. The close relation between algal biomass and bacterial cell counts (10(8)-10(9) cells g(-1) DW) supports the idea of bacterial use of the secreted EPS. However, the data also suggest a contribution to the EPS pool through bacterial secretion of proteins/extracellular enzymes and possibly carbohydrates. Over depth, the relationships between microorganisms and EPS became increasingly decoupled along with increasing ratios of bound (refractory) to colloidal (labile) EPS. These data suggest fresh production of polymeric substances in upper sediment layers and mainly accumulation of refractory, biodegraded material in deeper layers. The high contents of EPS colloidal and bound carbohydrates (0.1-1.8 and 1.3-6.7 mg g(-1) DW, respectively) and EPS proteins (0.4-12.9 mg g(-1) DW) at the freshwater study sites might indicate an important role in sediment ecology.

  19. Exopolysaccharide (EPS) Synthesis by Oenococcus oeni: From Genes to Phenotypes

    PubMed Central

    Dimopoulou, Maria; Vuillemin, Marlène; Campbell-Sills, Hugo; Lucas, Patrick M.; Ballestra, Patricia; Miot-Sertier, Cécile; Favier, Marion; Coulon, Joana; Moine, Virginie; Doco, Thierry; Roques, Maryline; Williams, Pascale; Petrel, Melina; Gontier, Etienne; Moulis, Claire; Remaud-Simeon, Magali; Dols-Lafargue, Marguerite

    2014-01-01

    Oenococcus oeni is the bacterial species which drives malolactic fermentation in wine. The analysis of 50 genomic sequences of O. oeni (14 already available and 36 newly sequenced ones) provided an inventory of the genes potentially involved in exopolysaccharide (EPS) biosynthesis. The loci identified are: two gene clusters named eps1 and eps2, three isolated glycoside-hydrolase genes named dsrO, dsrV and levO, and three isolated glycosyltransferase genes named gtf, it3, it4. The isolated genes were present or absent depending on the strain and the eps gene clusters composition diverged from one strain to another. The soluble and capsular EPS production capacity of several strains was examined after growth in different culture media and the EPS structure was determined. Genotype to phenotype correlations showed that several EPS biosynthetic pathways were active and complementary in O. oeni. Can be distinguished: (i) a Wzy -dependent synthetic pathway, allowing the production of heteropolysaccharides made of glucose, galactose and rhamnose, mainly in a capsular form, (ii) a glucan synthase pathway (Gtf), involved in β-glucan synthesis in a free and a cell-associated form, giving a ropy phenotype to growth media and (iii) homopolysaccharide synthesis from sucrose (α-glucan or β-fructan) by glycoside-hydrolases of the GH70 and GH68 families. The eps gene distribution on the phylogenetic tree was examined. Fifty out of 50 studied genomes possessed several genes dedicated to EPS metabolism. This suggests that these polymers are important for the adaptation of O. oeni to its specific ecological niche, wine and possibly contribute to the technological performance of malolactic starters. PMID:24901216

  20. Deeply Virtual Compton Scattering with CLAS

    SciTech Connect

    F.X. Girod

    2007-12-17

    The beam spin asymmetries of the reaction ep -> epg in the Bjorken regime were measured over a wide kinematical domain using the CLAS detector and a new lead-tungstate calorimeter. Through the interference of the Bethe-Heitler process with Deeply Virtual Compton Scattering, those asymmetries provide constraints for the nucleon Generalized Parton Distributions models. The observed shapes are in agreement with twist-2 dominance predictions.

  1. Resonance scattering at third-order exceptional points

    NASA Astrophysics Data System (ADS)

    Heiss, W. D.; Wunner, G.

    2015-08-01

    We analyze scattering cross sections at and near third-order exceptional points (EP3), i.e., points in physical parameter space where three energies and eigenfunctions coincide. At an EP3, the Green’s function contains a pole of third order, in addition to poles of second and first order. We show that the interference of the three pole terms produces a rich variety of line shapes at the exceptional point and in its neighbourhood. This is demonstrated by extending previous work on two harmonic oscillators to a system of three driven coupled damped oscillators. We also discuss the similarities and the differences in the behaviour of the amplitudes in the classical problem and the scattering cross sections in the quantum mechanical problem at the EP3.

  2. Clinician Attitudes Toward CDC Interim Pre-Exposure Prophylaxis (PrEP) Guidance and Operationalizing PrEP for Adolescents

    PubMed Central

    Lally, Michelle; Zimet, Gregory; Kahn, Jessica A.

    2015-01-01

    Abstract Prior to issuing formal HIV pre-exposure prophylaxis (PrEP) clinical practice guidelines in 2014, the US Centers for Disease Control and Prevention (CDC) had released interim guidance for oral PrEP use among adults. Because oral PrEP may be used off-label for youth and may soon be indicated for minor adolescents, we examined the potential adoption of the interim guidance among clinicians who care for HIV-infected and at-risk youth. Individual, semi-structured interviews were conducted with 15 US clinicians who were recruited through an adolescent HIV research network. The theory-driven interview guide, consisting primarily of open-ended questions, assessed demographics, familiarity with the guidance, attitudes toward the guidance, and attitudes toward the use of the guidance for adult and adolescent patients. Transcripts were analyzed using framework analysis. Most clinicians (11/15) reported that the guidance was compatible with their practice, although several reported that some aspects, particularly frequency of follow-up visits, needed to be tailored to meet their patients' needs. We found variability in clinician reported characteristics of appropriate PrEP candidates (e.g., youth with substance use and mental health issues were noted to be both suitable and unsuitable PrEP candidates) and PrEP use in serodiscordant couples (e.g., whether PrEP would be recommended to a patient whose HIV-infected partner is virally suppressed). Clinician reported steps for initiation, monitoring, and discontinuing PrEP were largely consistent with the guidance. The observed variability in clinician practice with regard to oral PrEP may be reduced through interventions to educate clinicians about the content and rationale for guideline recommendations. PMID:25692683

  3. Association Mechanisms of Sand with Anionic Extracellular Polysaccharides (EPS)

    NASA Astrophysics Data System (ADS)

    Albalasmeh, Ammar; Berhe, Asmeret; Ghezzehei, Teamrat

    2013-04-01

    The configuration, molecular weight and the type and charge of functional groups often have a strong effect on adhesion of Extracellular Polysaccharides (EPS) to solid surfaces. Our hypothesis is that the EPS with higher molecular weight will be more associated with sand as compared to those with a low molecular weight. In this study, we investigated the association of anionic EPS by sand of six size fractions. The association experiment was carried out at different time, initial concentrations, and sorbent concentrations. EPS concentrations were determined by Sulfuric Acid-UV method. Preliminary results indicate that increasing the concentration will lead to the formation of longer molecules. Therefore, more association with sand will be occurred until critical length is reached where increasing the length of the molecules will adversely affect the association.

  4. 48 CFR 504.570 - Procedures for using the EPS.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... (c) Although GSA intends that the EPS will substitute for paper copies of solicitations, web-based... ensure adequate security. In other cases, an exhibit or attachment incorporated in a solicitation may...

  5. PrEP implementation research in Africa: what is new?

    PubMed Central

    Cowan, Frances M; Delany-Moretlwe, Sinead; Sanders, Eduard J; Mugo, Nelly R; Guedou, Fernand A; Alary, Michel; Behanzin, Luc; Mugurungi, Owen; Bekker, Linda-Gail

    2016-01-01

    Introduction Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM), transgender women and injection drug users) are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW) are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. Discussion In each of the target populations, there are overarching issues related to (i) creating demand for PrEP, (ii) addressing supply-side issues and (iii) providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely to have an

  6. Optimization of amide-based EP3 receptor antagonists.

    PubMed

    Lee, Esther C Y; Futatsugi, Kentaro; Arcari, Joel T; Bahnck, Kevin; Coffey, Steven B; Derksen, David R; Kalgutkar, Amit S; Loria, Paula M; Sharma, Raman

    2016-06-01

    Prostaglandin E receptor subtype 3 (EP3) antagonism may treat a variety of symptoms from inflammation to cardiovascular and metabolic diseases. Previously, most EP3 antagonists were large acidic ligands that mimic the substrate, prostaglandin E2 (PGE2). This manuscript describes the optimization of a neutral small molecule amide series with improved lipophilic efficiency (LipE) also known as lipophilic ligand efficiency (LLE) ((a) Nat. Rev. Drug Disc.2007, 6, 881; (b) Annu. Rep. Med. Chem.2010, 45, 380).

  7. Contribution of Δ(1232) to real photon radiative corrections for elastic electron-proton scattering

    NASA Astrophysics Data System (ADS)

    Gerasimov, R. E.; Fadin, V. S.

    2016-12-01

    Here we consider the contribution of the Δ(1232) resonance to the real photon radiative corrections for elastic ep-scattering. The effect is found to be small for past experiments studying the unpolarized cross section, as well as for the recent VEPP-3 experiment investigating two-photon exchange effects by the precision measurement of the {e}+/- p-scattering cross section ratio.

  8. SU-E-T-15: A Comparison of COMS and EP917 Eye Plaque Applicators Using Different Radionuclides

    SciTech Connect

    Aryal, P; Molloy, JA; Rivard, MJ

    2015-06-15

    Purpose: To investigate the effect of plaque design and radionuclides on eye plaque dosimetry. Methods: The Monte Carlo N-particle Code version 6 (MCNP6) was used for radiation transport simulations. The 14 mm and 16 mm diameter COMS plaques and the model EP917 plaque were simulated using brachytherapy seeds containing I-125, Pd-103, and Cs-131 radionuclides. The origin was placed at the scleral inner surface. The central axis (CAX) doses of both COMS plaques at −1 mm, 0 mm, 1 mm, 2 mm, 5 mm, 10 mm, 15 mm, 20 mm, and 22.6 mm were compared to the model EP917 plaque. Dose volume histograms (DVHs) were also created for both COMS plaques for the tumor and outer sclera then compared to results for the model EP917 plaque. Results: For all radionuclides, the EP917 plaque delivered higher dose (max 343%) compared to the COMS plaques, except for the 14 mm COMS plaque with Cs-131 at 1 mm and 2 mm depths from outer sclera surface. This could be due to source design. For all radionuclides, the 14 mm COMS plaque delivered higher doses compared to the 16 mm COMS plaque for the depths up to 5 mm. Dose differences were not significant beyond depths of 10 mm due to ocular lateral scatter for the different plaque designs. Tumor DVHs for the 16 mm COMS plaque with Cs-131 provided better dose homogeneity and conformity compared to other COMS plaques with I-125 and Pd-103. Using Pd-103, DVHs for the 16 mm COMS plaque delivered less dose to outer sclera compared to other plaques. Conclusion: This study identified improved tumor homogeneity upon considering radionuclides and plaque designs, and found that scleral dose with the model EP917 plaque was higher than for the 16 mm COMS plaque for all the radionuclides studied.

  9. Determination of the Strange-Quark Density of the Proton from ATLAS Measurements of the W→ℓν and Z→ℓℓ Cross Sections

    NASA Astrophysics Data System (ADS)

    Aad, G.; Abbott, B.; Abdallah, J.; Abdelalim, A. A.; Abdesselam, A.; Abdinov, O.; Abi, B.; Abolins, M.; AbouZeid, O. S.; Abramowicz, H.; Abreu, H.; Acerbi, E.; Acharya, B. S.; Adamczyk, L.; Adams, D. L.; Addy, T. N.; Adelman, J.; Aderholz, M.; Adomeit, S.; Adragna, P.; Adye, T.; Aefsky, S.; Aguilar-Saavedra, J. A.; Aharrouche, M.; Ahlen, S. P.; Ahles, F.; Ahmad, A.; Ahsan, M.; Aielli, G.; Akdogan, T.; Åkesson, T. P. A.; Akimoto, G.; Akimov, A. V.; Akiyama, A.; Alam, M. S.; Alam, M. A.; Albert, J.; Albrand, S.; Aleksa, M.; Aleksandrov, I. N.; Alessandria, F.; Alexa, C.; Alexander, G.; Alexandre, G.; Alexopoulos, T.; Alhroob, M.; Aliev, M.; Alimonti, G.; Alison, J.; Aliyev, M.; Allbrooke, B. M. M.; Allport, P. P.; Allwood-Spiers, S. E.; Almond, J.; Aloisio, A.; Alon, R.; Alonso, A.; Alvarez Gonzalez, B.; Alviggi, M. G.; Amako, K.; Amaral, P.; Amelung, C.; Ammosov, V. V.; Amorim, A.; Amorós, G.; Amram, N.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, G.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Andrieux, M.-L.; Anduaga, X. S.; Angerami, A.; Anghinolfi, F.; Anisenkov, A.; Anjos, N.; Annovi, A.; Antonaki, A.; Antonelli, M.; Antonov, A.; Antos, J.; Anulli, F.; Aoun, S.; Aperio Bella, L.; Apolle, R.; Arabidze, G.; Aracena, I.; Arai, Y.; Arce, A. T. H.; Arfaoui, S.; Arguin, J.-F.; Arik, E.; Arik, M.; Armbruster, A. J.; Arnaez, O.; Arnault, C.; Artamonov, A.; Artoni, G.; Arutinov, D.; Asai, S.; Asfandiyarov, R.; Ask, S.; Åsman, B.; Asquith, L.; Assamagan, K.; Astbury, A.; Astvatsatourov, A.; Aubert, B.; Auge, E.; Augsten, K.; Aurousseau, M.; Avolio, G.; Avramidou, R.; Axen, D.; Ay, C.; Azuelos, G.; Azuma, Y.; Baak, M. A.; Baccaglioni, G.; Bacci, C.; Bach, A. M.; Bachacou, H.; Bachas, K.; Backes, M.; Backhaus, M.; Badescu, E.; Bagnaia, P.; Bahinipati, S.; Bai, Y.; Bailey, D. C.; Bain, T.; Baines, J. T.; Baker, O. K.; Baker, M. D.; Baker, S.; Banas, E.; Banerjee, P.; Banerjee, Sw.; Banfi, D.; Bangert, A.; Bansal, V.; Bansil, H. S.; Barak, L.; Baranov, S. P.; Barashkou, A.; Barbaro Galtieri, A.; Barber, T.; Barberio, E. L.; Barberis, D.; Barbero, M.; Bardin, D. Y.; Barillari, T.; Barisonzi, M.; Barklow, T.; Barlow, N.; Barnett, B. M.; Barnett, R. M.; Baroncelli, A.; Barone, G.; Barr, A. J.; Barreiro, F.; Barreiro Guimarães da Costa, J.; Barrillon, P.; Bartoldus, R.; Barton, A. E.; Bartsch, V.; Bates, R. L.; Batkova, L.; Batley, J. R.; Battaglia, A.; Battistin, M.; Bauer, F.; Bawa, H. S.; Beale, S.; Beau, T.; Beauchemin, P. H.; Beccherle, R.; Bechtle, P.; Beck, H. P.; Becker, S.; Beckingham, M.; Becks, K. H.; Beddall, A. J.; Beddall, A.; Bedikian, S.; Bednyakov, V. A.; Bee, C. P.; Begel, M.; Behar Harpaz, S.; Behera, P. K.; Beimforde, M.; Belanger-Champagne, C.; Bell, P. J.; Bell, W. H.; Bella, G.; Bellagamba, L.; Bellina, F.; Bellomo, M.; Belloni, A.; Beloborodova, O.; Belotskiy, K.; Beltramello, O.; Ben Ami, S.; Benary, O.; Benchekroun, D.; Benchouk, C.; Bendel, M.; Benekos, N.; Benhammou, Y.; Benhar Noccioli, E.; Benitez Garcia, J. A.; Benjamin, D. P.; Benoit, M.; Bensinger, J. R.; Benslama, K.; Bentvelsen, S.; Berge, D.; Bergeaas Kuutmann, E.; Berger, N.; Berghaus, F.; Berglund, E.; Beringer, J.; Bernat, P.; Bernhard, R.; Bernius, C.; Berry, T.; Bertella, C.; Bertin, A.; Bertinelli, F.; Bertolucci, F.; Besana, M. I.; Besson, N.; Bethke, S.; Bhimji, W.; Bianchi, R. M.; Bianco, M.; Biebel, O.; Bieniek, S. P.; Bierwagen, K.; Biesiada, J.; Biglietti, M.; Bilokon, H.; Bindi, M.; Binet, S.; Bingul, A.; Bini, C.; Biscarat, C.; Bitenc, U.; Black, K. M.; Blair, R. E.; Blanchard, J.-B.; Blanchot, G.; Blazek, T.; Blocker, C.; Blocki, J.; Blondel, A.; Blum, W.; Blumenschein, U.; Bobbink, G. J.; Bobrovnikov, V. B.; Bocchetta, S. S.; Bocci, A.; Boddy, C. R.; Boehler, M.; Boek, J.; Boelaert, N.; Bogaerts, J. A.; Bogdanchikov, A.; Bogouch, A.; Bohm, C.; Boisvert, V.; Bold, T.; Boldea, V.; Bolnet, N. M.; Bona, M.; Bondarenko, V. G.; Bondioli, M.; Boonekamp, M.; Booth, C. N.; Bordoni, S.; Borer, C.; Borisov, A.; Borissov, G.; Borjanovic, I.; Borri, M.; Borroni, S.; Bortolotto, V.; Bos, K.; Boscherini, D.; Bosman, M.; Boterenbrood, H.; Botterill, D.; Bouchami, J.; Boudreau, J.; Bouhova-Thacker, E. V.; Boumediene, D.; Bourdarios, C.; Bousson, N.; Boveia, A.; Boyd, J.; Boyko, I. R.; Bozhko, N. I.; Bozovic-Jelisavcic, I.; Bracinik, J.; Braem, A.; Branchini, P.; Brandenburg, G. W.; Brandt, A.; Brandt, G.; Brandt, O.; Bratzler, U.; Brau, B.; Brau, J. E.; Braun, H. M.; Brelier, B.; Bremer, J.; Brenner, R.; Bressler, S.; Britton, D.; Brochu, F. M.; Brock, I.; Brock, R.; Brodbeck, T. J.; Brodet, E.; Broggi, F.; Bromberg, C.; Bronner, J.; Brooijmans, G.; Brooks, W. K.; Brown, G.; Brown, H.; Bruckman de Renstrom, P. A.; Bruncko, D.; Bruneliere, R.; Brunet, S.; Bruni, A.; Bruni, G.

    2012-07-01

    A QCD analysis is reported of ATLAS data on inclusive W± and Z boson production in pp collisions at the LHC, jointly with ep deep-inelastic scattering data from HERA. The ATLAS data exhibit sensitivity to the light quark sea composition and magnitude at Bjorken x˜0.01. Specifically, the data support the hypothesis of a symmetric composition of the light quark sea at low x. The ratio of the strange-to-down sea quark distributions is determined to be 1.00-0.28+0.25 at absolute four-momentum transfer squared Q2=1.9GeV2 and x=0.023.

  10. Neutral current neutrino-nucleus interactions at high energies

    SciTech Connect

    Gay Ducati, M. B.; Machado, M. M.; Machado, M. V. T.

    2009-04-01

    We present a QCD analysis of the neutral current (NC) neutrino-nucleus interaction at the small-x region using the color dipole formalism. This phenomenological approach is quite successful in describing experimental results in deep inelastic ep scattering and charged current neutrino-nucleus interactions at high energies. We present theoretical predictions for the relevant structure functions and the corresponding implications for the total NC neutrino cross section. It is shown that at small x, the NC boson-nucleon cross section should exhibit the geometric scaling property that has important consequences for ultrahigh energy neutrino phenomenology.

  11. Jets and Heavy Flavors at HERA

    SciTech Connect

    Shehzadi, R.

    2011-07-15

    Recent results on jet cross sections and heavy-flavor production in photoproduction and neutral current deep inelastic ep scattering from the H1 and ZEUS Collaborations are presented. The jet measurements are used to perform stringent tests of perturbative QCD, to extract precise values of the strong coupling and to constrain further the proton and photon parton distribution functions. The measurement of beauty and charm production at HERA is an important testing ground for perturbative QCD and can provide information on the structure of the proton.

  12. Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2

    PubMed Central

    Jones, Victoria C; Birrell, Mark A; Maher, Sarah A; Griffiths, Mark; Grace, Megan; O'Donnell, Valerie B; Clark, Stephen R

    2016-01-01

    Background and Purpose Airway microvascular leak (MVL) involves the extravasation of proteins from post‐capillary venules into surrounding tissue. MVL is a cardinal sign of inflammation and an important feature of airway inflammatory diseases such as asthma. PGE2, a product of COX‐mediated metabolism of arachidonic acid, binds to four receptors, termed EP1–4. PGE2 has a wide variety of effects within the airway, including modulation of inflammation, sensory nerve activation and airway tone. However, the effect of PGE2 on airway MVL and the receptor/s that mediate this have not been described. Experimental Approach Evans Blue dye was used as a marker of airway MVL, and selective EP receptor agonists and antagonists were used alongside EP receptor‐deficient mice to define the receptor subtype involved. Key Results PGE2 induced significant airway MVL in mice and guinea pigs. A significant reduction in PGE2‐induced MVL was demonstrated in Ptger2 −/− and Ptger4 −/− mice and in wild‐type mice pretreated simultaneously with EP2 (PF‐04418948) and EP4 (ER‐819762) receptor antagonists. In a model of allergic asthma, an increase in airway levels of PGE2 was associated with a rise in MVL; this change was absent in Ptger2 −/− and Ptger4 −/− mice. Conclusions and Implications PGE2 is a key mediator produced by the lung and has widespread effects according to the EP receptor activated. Airway MVL represents a response to injury and under ‘disease’ conditions is a prominent feature of airway inflammation. The data presented highlight a key role for EP2 and EP4 receptors in MVL induced by PGE2. PMID:26639895

  13. Analysis of pion production data in electron-hadron scattering at JLAB using the TMD Parton Model Formalism

    NASA Astrophysics Data System (ADS)

    Warmate, Tamuno-Negiyeofori; Gamberg, Leonard; Prokudin, Alexei

    2016-09-01

    I have performed a phenomenological analysis of pion production data from Jefferson Laboratory in semi-inclusive deep inelastic scattering of electrons on unpolarized nucleons and deuterium using the transverse momentum dependent (TMD) parton model formalism. We parameterize the data in terms of TMD parton distribution functions that describe the three-dimensional (3-D) partonic structure of the nucleon. One of the main enigmas of data analysis is how to reliably estimate the errors of the parameters that describe some particular physical process. A common method is to use Hessian matrix or vary the delta chi-square of the corresponding fits to the data. In this particular project we use the so-called bootstrap method that is very robust for error estimation. This method has not been extensively used in the description of the TMD distributions that describe the 3-D nucleon structure. The reliable estimate of the errors and thus reliable predictions for future experiments is of great scientific interest. We are using Python and modern methods of data analysis in this project. The results of the project will be useful for understanding the effects of internal motion of quarks and gluons inside of the proton and will be reported in a forthcoming publication.

  14. Production and Characterization of the Intra- and Extracellular Carbohydrates and Polymeric Substances (EPS) of Three Sea-Ice Diatom Species, and Evidence for a Cryoprotective Role for EPS.

    PubMed

    Aslam, Shazia N; Cresswell-Maynard, Tania; Thomas, David N; Underwood, Graham J C

    2012-12-01

    Diatoms and their associated extracellular polymeric substances (EPS) are major constituents of the microalgal assemblages present within sea ice. Yields and chemical composition of soluble and cell-associated polysaccharides produced by three sea-ice diatoms, Synedropsis sp., Fragilariopsis curta, and F. cylindrus, were compared. Colloidal carbohydrates (CC) contained heteropolysaccharides rich in mannose, xylose, galactose, and glucose. Synedropsis sp. CC consisted mainly of carbohydrates <8 kDa size, with relatively soluble EPS, compared to high proportions of less-soluble EPS produced by both Fragilariopsis spp. F. curta colloidal EPS contained high concentrations of amino sugars (AS). Both Fragilariopsis species had high yields of hot bicarbonate (HB) soluble EPS, rich in xylose, mannose, galactose, and fucose (and AS in F. cylindrus). All species had frustule-associated EPS rich in glucose-mannose. Nutrient limitation resulted in declines in EPS yields and in glucose content of all EPS fractions. Significant similarities between EPS fractions from cultures and different components of natural EPS from Antarctic sea ice were found. Increased salinity (52) reduced growth, but increased yields of EPS in Fragilariopsis cylindrus. Ice formation was inhibited byF. cylindrus, EPS, and by enhanced EPS content (additional xanthan gum) down to -12°C, with growth rate reduced in the presence of xanthan. Differences in the production and composition of EPS between Synedropsis sp. and Fragilariopsis spp., and the association between EPS, freezing and cell survival, supports the hypothesis that EPS production is a strategy to assist polar ice diatoms to survive the cold and saline conditions present in sea ice.

  15. EP300 Protects from Light-Induced Retinopathy in Zebrafish

    PubMed Central

    Kawase, Reiko; Nishimura, Yuhei; Ashikawa, Yoshifumi; Sasagawa, Shota; Murakami, Soichiro; Yuge, Mizuki; Okabe, Shiko; Kawaguchi, Koki; Yamamoto, Hiroshi; Moriyuki, Kazumi; Yamane, Shinsaku; Tsuruma, Kazuhiro; Shimazawa, Masamitsu; Hara, Hideaki; Tanaka, Toshio

    2016-01-01

    Exposure of rhodopsin to bright white light can induce photoreceptor cell damage and degeneration. However, a comprehensive understanding of the mechanisms underlying light-induced retinopathy remains elusive. In this study, we performed comparative transcriptome analysis of three rodent models of light-induced retinopathy, and we identified 37 genes that are dysregulated in all three models. Gene ontology analysis revealed that this gene set is significantly associated with a cytokine signaling axis composed of signal transducer and activator of transcription 1 and 3 (STAT1/3), interleukin 6 signal transducer (IL6ST), and oncostatin M receptor (OSMR). Furthermore, the analysis suggested that the histone acetyltransferase EP300 may be a key upstream regulator of the STAT1/3–IL6ST/OSMR axis. To examine the role of EP300 directly, we developed a larval zebrafish model of light-induced retinopathy. Using this model, we demonstrated that pharmacological inhibition of EP300 significantly increased retinal cell apoptosis, decreased photoreceptor cell outer segments, and increased proliferation of putative Müller cells upon exposure to intense light. These results suggest that EP300 may protect photoreceptor cells from light-induced damage and that activation of EP300 may be a novel therapeutic approach for the treatment of retinal degenerative diseases. PMID:27242532

  16. NEXT GENERATION ORAL PrEP: BEYOND TENOFOVIR

    PubMed Central

    Abraham, Bisrat K.; Gulick, Roy

    2013-01-01

    Purpose Clinical trials of oral pre-exposure prophylaxis (PrEP) have focused testing on regimens of tenofovir (TDF) with or without emtricitabine (FTC). However, TDF may be associated with toxicities (renal, bone) and FTC may select for drug resistance. In this review, we discuss agents that might serve as alternatives to TDF/FTC for HIV prevention. Recent Findings Several drug characteristics are important to consider when selecting agents for PrEP with the most critical being safety, tolerability, adequate penetration into target tissues, prevention of HIV infection, and long lasting activity with convenient dosing. With these factors in mind, we review several potentially useful agents for PrEP. The first group includes drugs that are already FDA-approved (maraviroc, raltegravir) with attributes that make them attractive for PrEP. The second groups of drugs include investigational agents with long-lasting activities that are being developed in parenteral form (rilpivirine-long acting, S/GSK 1265744, ibalizumab). Summary Current research suggests there will be a broader array of PrEP drugs to choose from in the near future, thereby giving clinicians the flexibility to select agents that best suit the needs of their patient population. PMID:23032733

  17. Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia.

    PubMed

    Jeske, Nathaniel A; Berg, Kelly A; Cousins, Joanne C; Ferro, Emer S; Clarke, William P; Glucksman, Marc J; Roberts, James L

    2006-04-01

    Metalloendopeptidases expressed in neural tissue are characterized in terms of their neuropeptide substrates. One such neuropeptide, bradykinin (BK), is an important inflammatory mediator that activates the type-2 BK receptor (B2R) on the terminal endings of specialized pain-sensing neurons known as nociceptors. Among several metalloendopeptidases that metabolize and inactivate BK, EP24.15 and EP24.16 are known to associate with the plasma membrane in several immortalized cell lines. Potentially, the colocalization of EP24.15/16 and B2R at plasma membrane microdomains known as lipid rafts in a physiologically relevant nociceptive system would allow for discrete, peptidase regulation of BK signaling. Western blot analysis of crude subcellular fractions and lipid raft preparations of cultured rat trigeminal ganglia demonstrate similar expression profiles between EP24.15/16 and B2R on a subcellular level. Furthermore, the treatment of primary cultures of trigeminal ganglia with inhibitors of EP24.15/16 led to the potentiation of several bradykinin-induced events that occur downstream of B2R activation. EP24.15/16 inhibition by N-[1(R,S)-carboxy-3-phenylpropyl]-Ala-AlalTyr-p-aminobenzoate (cFP) resulted in a 1000-fold increase in B2R sensitivity to BK as measured by inositol phosphate accumulation. In addition, cFP treatment resulted in a 31.1+/-5.0% potentiation of the ability of BK to inhibit protein kinase B (Akt) activity. Taken together, these data demonstrate that EP24.15/16 modulate intracellular, peptidergic signaling cascades through B2R in a physiologically relevant nociceptive system.

  18. EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells

    PubMed Central

    Chun, Kyung-Soo; Shim, Minsub

    2015-01-01

    Prostaglandin E2 (PGE2), a major product of cyclooxygenase, binds to four different prostaglandin E2 receptors (EP1, EP2, EP3, and EP4) which are G-protein coupled transmembrane receptors (GPCRs). Although GPCRs including EP receptors have been shown to be associated with their specific G proteins, recent evidences suggest that GPCRs can regulate MAPK signaling via non-G protein coupled pathways including Src. EP2 is differentially expressed in various tissues and the expression of EP2 is induced by extracellular stimuli. We hypothesized that an increased level of EP2 expression may affect MAPK signaling. The overexpression of EP2 in HEK 293 cells resulted in significant increase in intracellular cAMP levels response to treatment with butaprost, a specific EP2 agonist, while overexpression of EP2 alone did not increase intracellular cAMP levels. However, EP2 overexpression in the absence of PGE2 induced an increase in the level of p38 phosphorylation as well as the kinase activity of p38, suggesting that up-regulation of EP2 may promote p38 activation via non-G protein coupled pathway. Inhibition of Src completely blocked EP2-induced p38 phosphorylation and overexpression of Src increased the level of p38 phosphorylation, indicating that Src is upstream kinase for EP2-induced p38 phosphorylation. EP2 overexpression also increased the Src activity and EP2 protein was co-immunoprecipitated with Src. Furthermore, sequential co-immunoprecipitation studies showed that EP2, Src, and β-arrestin can form a complex. Our study found a novel pathway in which EP2 is associated with Src, regulating p38 pathway. PMID:26535079

  19. Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue

    PubMed Central

    Xu, Hu; Fu, Jia-Lin; Miao, Yi-Fei; Wang, Chun-Jiong; Han, Qi-Fei; Li, Sha; Huang, Shi-Zheng; Du, Sheng-Nan; Qiu, Yu-Xiang; Yang, Ji-Chun; Gustafsson, Jan-Åke; Breyer, Richard M.; Zheng, Feng; Wang, Nan-Ping; Zhang, Xiao-Yan; Guan, You-Fei

    2016-01-01

    Among the four prostaglandin E2 receptors, EP3 receptor is the one most abundantly expressed in white adipose tissue (WAT). The mouse EP3 gene gives rise to three isoforms, namely EP3α, EP3β, and EP3γ, which differ only at their C-terminal tails. To date, functions of EP3 receptor and its isoforms in WAT remain incompletely characterized. In this study, we found that the expression of all EP3 isoforms were downregulated in WAT of both db/db and high-fat diet-induced obese mice. Genetic ablation of three EP3 receptor isoforms (EP3−/− mice) or EP3α and EP3γ isoforms with EP3β intact (EP3β mice) led to an obese phenotype with increased food intake, decreased motor activity, reduced insulin sensitivity, and elevated serum triglycerides. Since the differentiation of preadipocytes and mouse embryonic fibroblasts to adipocytes was markedly facilitated by either pharmacological blockade or genetic deletion/inhibition of EP3 receptor via the cAMP/PKA/PPARγ pathway, increased adipogenesis may contribute to obesity in EP3−/− and EP3β mice. Moreover, both EP3−/− and EP3β mice had increased lipolysis in WAT mainly due to the activated cAMP/PKA/hormone-sensitive lipase pathway. Taken together, our findings suggest that EP3 receptor and its α and γ isoforms are involved in both adipogenesis and lipolysis and influence food intake, serum lipid levels, and insulin sensitivity. PMID:27436752

  20. Non-linear QCD dynamics and exclusive production in ep collisions

    NASA Astrophysics Data System (ADS)

    Gonçalves, V. P.; Machado, M. V. T.; Meneses, A. R.

    2010-07-01

    The exclusive processes in electron-proton ( ep) interactions are an important tool to investigate the QCD dynamics at high energies as they are in general driven by the gluon content of proton which is strongly subject to parton saturation effects. In this paper we compute the cross sections for the exclusive vector meson production as well as the deeply virtual Compton scattering (DVCS) relying on the color dipole approach and considering the numerical solution of the Balitsky-Kovchegov equation including running coupling corrections. We show that the small- x evolution given by this evolution equation is able to describe the DESY-HERA data and is relevant for the physics of the exclusive observables in future electron-proton colliders and in photoproduction processes to be measured in coherent interactions at the LHC.

  1. Design Method for EPS Control System Based on KANSEI Structure

    NASA Astrophysics Data System (ADS)

    Saitoh, Yumi; Itoh, Hideaki; Ozaki, Fuminori; Nakamura, Takenobu; Kawaji, Shigeyasu

    Recently, it has been identified that a KANSEI engineering plays an important role in functional design developing for realizing highly sophisticated products. However, in practical development methods, we design products and optimise the design trial and error, which indecates that we depend on the skill set of experts. In this paper, we focus on an automobile electric power steering (EPS) for which a functional design is required. First, the KANSEI structure is determined on the basis of the steering feeling of an experienced driver, and an EPS control design based on this KANSEI structure is proposed. Then, the EPS control parameters are adjusted in accordance with the KANSEI index. Finally, by assessing the experimental results obtained from the driver, the effectiveness of the proposed design method is verified.

  2. Sample EP Flow Analysis of Severely Damaged Networks

    SciTech Connect

    Werley, Kenneth Alan; McCown, Andrew William

    2016-10-12

    These are slides for a presentation at the working group meeting of the WESC SREMP Software Product Integration Team on sample EP flow analysis of severely damaged networks. The following topics are covered: ERCOT EP Transmission Model; Zoomed in to Houston and Overlaying StreetAtlas; EMPACT Solve/Dispatch/Shedding Options; QACS BaseCase Power Flow Solution; 3 Substation Contingency; Gen. & Load/100 Optimal Dispatch; Dispatch Results; Shed Load for Low V; Network Damage Summary; Estimated Service Areas (Potential); Estimated Outage Areas (potential).

  3. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro.

    PubMed

    Shin, Vivian Y; Jin, Hong C; Ng, Enders K O; Cho, Chi H; Leung, Wai K; Sung, Joseph J Y; Chu, Kent-Man

    2011-05-01

    Prostaglandin E (EP) receptor is positively related with COX-2, which is involved in cancer biology. A mechanistic study on how 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) promotes gastric carcinogenesis is lacking. Recently, we found that nicotine promoted tumor growth through upregulation of the COX-2/prostaglandin E(2) pathway. This extended our study on the involvement of EP receptors in gastric carcinogenesis. Both in vitro and in vivo studies showed that NNK promoted cancer cell growth with concomitant EP2 and EP4 upregulation. We found that NNK stimulated vascular endothelial growth factor (VEGF) and angiogenesis, but suppressed apoptosis by increasing Bcl2 and decreasing caspase-3 expressions. Both EP2 and EP4 siRNA significantly impaired these tumorigenic actions of NNK in xenograft tumor. Cell cycle analysis showed that NNK increased S phase entry with increased cyclin D1 and the associated cyclin-dependent kinase 4/6, and downregulation of p21 and p27. The p38 phosphorylation was EP2/4-dependent, and SB203580 (p38 inhibitor) suppressed NNK-induced prostaglandin E(2) , VEGF, and cell proliferation. Antagonists of EP2 or EP4 abolished the elevated VEGF and VEGF receptor-2. These data strongly indicate that EP2/4 are important for NNK-promoted gastric carcinogenesis, thus providing a framework for future evaluation of EP antagonist(s) as anticancer drugs for smokers.

  4. Prostaglandin EP2 and EP4 receptors modulate expression of the chemokine CCL2 (MCP-1) in response to LPS-induced renal glomerular inflammation.

    PubMed

    Zahner, Gunther; Schaper, Melanie; Panzer, Ulf; Kluger, Malte; Stahl, Rolf A K; Thaiss, Friedrich; Schneider, André

    2009-08-27

    The pro-inflammatory chemokine CCL2 [chemokine (Cys-Cys motif) ligand 2; also known as MCP-1 (monocyte chemotactic protein-1)] is up-regulated in the glomerular compartment during the early phase of LPS (lipopolysaccharide)-induced nephritis. This up-regulation also occurs in cultured MCs (mesangial cells) and is more pronounced in MCs lacking the PGE2 (prostaglandin E2) receptor EP2 or in MCs treated with a prostaglandin EP4 receptor antagonist. To examine a possible feedback mechanism of EP receptor stimulation on CCL2 expression, we used an in vitro model of MCs with down-regulated EP receptor expression. Selectively overexpressing the various EP receptors in these cells then allows the effects on the LPS-induced CCL2 expression to be examined. Cells were stimulated with LPS and CCL2 gene expression was examined and compared with LPS-stimulated, mock-transfected PTGS2 [prostaglandin-endoperoxide synthase 2, also known as COX-2 (cyclo-oxygenase-2)]-positive cells. Overexpression of EP1, as well as EP3, had no effect on LPS-induced Ccl2 mRNA expression. In contrast, overexpression of EP2, as well as EP4, significantly decreased LPS-induced CCL2 expression. These results support the hypothesis that PTGS2-derived prostaglandins, when strongly induced, counter-balance inflammatory processes through the EP2 and EP4 receptors in MCs.

  5. Functional and bioinformatics analysis of an exopolysaccharide-related gene (epsN) from Lactobacillus kefiranofaciens ZW3.

    PubMed

    Wang, Jingrui; Tang, Wei; Zheng, Yongna; Xing, Zhuqing; Wang, Yanping

    2016-09-01

    A novel lactic acid bacteria strain Lactobacillus kefiranofaciens ZW3 exhibited the characteristics of high production of exopolysaccharide (EPS). The epsN gene, located in the eps gene cluster of this strain, is associated with EPS biosynthesis. Bioinformatics analysis of this gene was performed. The conserved domain analysis showed that the EpsN protein contained MATE-Wzx-like domains. Then the epsN gene was amplified to construct the recombinant expression vector pMG36e-epsN. The results showed that the EPS yields of the recombinants were significantly improved. By determining the yields of EPS and intracellular polysaccharide, it was considered that epsN gene could play its Wzx flippase role in the EPS biosynthesis. This is the first time to prove the effect of EpsN on L. kefiranofaciens EPS biosynthesis and further prove its functional property.

  6. Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2.

    PubMed

    Fujino, Hiromichi; West, Kimberly A; Regan, John W

    2002-01-25

    Recently we have shown that the FP(B) prostanoid receptor, a G-protein-coupled receptor that couples to Galpha(q), activates T-cell factor (Tcf)/lymphoid enhancer factor (Lef)-mediated transcriptional activation (Fujino, H., and Regan, J. W. (2001) J. Biol. Chem. 276, 12489-12492). We now report that the EP(2) and EP(4) prostanoid receptors, which couple to Galpha(s), also activate Tcf/Lef signaling. By using a Tcf/Lef-responsive luciferase reporter gene, transcriptional activity was stimulated approximately 10-fold over basal by 1 h of treatment with prostaglandin E(2) (PGE(2)) in HEK cells that were stably transfected with the human EP(2) and EP(4) receptors. This stimulation of reporter gene activity was accompanied by a PGE(2)-dependent increase in the phosphorylation of both glycogen synthase kinase-3 (GSK-3) and Akt kinase. H-89, an inhibitor of protein kinase A (PKA), completely blocked the agonist-dependent phosphorylation of GSK-3 in both EP(2)- and EP(4)-expressing cells. However, H-89 pretreatment only blocked PGE(2)-stimulated Lef/Tcf reporter gene activity by 20% in EP(4)-expressing cells compared with 65% inhibition in EP(2)-expressing cells. On the other hand wortmannin, an inhibitor of phosphatidylinositol 3-kinase, had the opposite effect and inhibited PGE(2)-stimulated reporter gene activity to a much greater extent in EP(4)-expressing cells as compared with EP(2)-expressing cells. These findings indicate that the activation of Tcf/Lef signaling by EP(2) receptors occurs primarily through a PKA-dependent pathway, whereas EP(4) receptors activate Tcf/Lef signaling mainly through a phosphatidylinositol 3-kinase-dependent pathway. This is the first indication of a fundamental difference in the signaling potential of EP(2) and EP(4) prostanoid receptors.

  7. Role of microbial exopolymeric substances (EPS) on chromium sorption and transport in heterogeneous subsurface soils: II. Binding of Cr(III) in EPS/soil system.

    PubMed

    Kantar, Cetin; Demiray, Hilal; Dogan, Nazime Mercan

    2011-03-01

    Laboratory batch sorption and column experiments were performed to investigate the effects of microbial EPSs isolated from Pseudomonas putida P18, Pseudomonas aeruginosa P16 and Pseudomonas stutzeri P40 on Cr(III) mobility in heterogeneous subsurface soils. Our batch and column results indicate that microbial EPS may have a pronounced effect on Cr(III) sorption and transport behavior depending on system conditions (e.g., pH, type of EPS). While EPS had no effect on Cr(III) sorption at pH<5, it led to a significant decrease in Cr(III) sorption under slightly acidic to alkaline pH range. Column experiments performed at pH 7.9 suggest that, in the presence of EPS, chromium(III) was significantly mobilized relative to non-EPS containing system due to the formation less sorbing and highly soluble Cr-EPS complexes and competition of EPS against Cr for surface sites. A two-site non-electrostatic surface chemical model incorporating a discrete ligand approach for the description of Cr-EPS interactions accurately predicted Cr(III) sorption and transport behavior in the presence of EPS under variable chemical conditions. Our simulations show that an accurate description of Cr(III) transport in the presence of EPS requires incorporation of proton and Cr(III) binding by EPS, EPS binding by soil minerals, Cr(III) binding by soil minerals, and ternary Cr(III)-EPS surface complexes into the transport equations. Although this approach may not accurately describe the actual mechanisms at the molecular level, it can improve our ability to accurately describe the effects of EPS on Cr(III) mobility in subsurface environment relative to the use of distribution coefficients (K(d)).

  8. Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2.

    PubMed

    Fujino, Hiromichi; Salvi, Sambhitab; Regan, John W

    2005-07-01

    The EP2 and EP4 prostanoid receptors are G-protein-coupled receptors whose activation by their endogenous ligand, prostaglandin (PG) E2, stimulates the formation of intracellular cAMP. We have previously reported that the stimulation of cAMP formation in EP4-expressing cells is significantly less than in EP2-expressing cells, despite nearly identical levels of receptor expression (J Biol Chem 277:2614-2619, 2002). In addition, a component of EP4 receptor signaling, but not of EP2 receptor signaling, was found to involve the activation of phosphatidylinositol 3-kinase (PI3K). In this study, we report that PGE2 stimulation of cells expressing either the EP2 or EP4 receptor results in the phosphorylation of the cAMP response element binding protein (CREB) at serine-133. Pretreatment of cells with N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H-89), an inhibitor of protein kinase A (PKA), attenuated the PGE2-mediated phosphorylation of CREB in EP2-expressing cells, but not in EP4-expressing cells. Pretreatment of cells with wortmannin, an inhibitor of PI3K, had no effects on the PGE2-mediated phosphorylation of CREB in either EP2- or EP4-expressing cells, although it significantly increased the PGE2-mediated activation of PKA in EP4-expressing cells. However, combined pretreatment with H-89 and wortmannin blocked PGE2-mediated phosphorylation in EP2-expressing cells as well as in EP2-expressing cells. PGE2-mediated intracellular cAMP formation was not affected by pretreatment with wortmannin, or combined treatment with wortmannin and H-89, in either the EP2- or EP4-expressing cells. These findings suggest that PGE2 stimulation of EP4 receptors, but not EP2 receptors, results in the activation of a PI3K signaling pathway that inhibits the activity of PKA and that the PGE2-mediated phosphorylation of CREB by these receptors occurs through different signaling pathways

  9. 42 CFR 495.102 - Incentive payments to EPs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Incentive payments to EPs. 495.102 Section 495.102 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY...

  10. 48 CFR 504.570 - Procedures for using the EPS.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GENERAL ADMINISTRATIVE MATTERS Electronic Commerce in Contracting 504.570 Procedures for using the EPS. (a... writing the Contracting Officer at the address in . (e) The Electronic Posting System Manual provides... that electronic access to a solicitation will result in adequate competition, distribute...

  11. Stratification of extracellular polymeric substances (EPS) for aggregated anammox microorganisms.

    PubMed

    Jia, Fangxu; Yang, Qing; Liu, Xiuhong; Li, Xiyao; Li, Baikun; Zhang, Liang; Peng, Yongzhen

    2017-02-27

    Sludge aggregation and biofilm formation are the most effective approaches to solve the washout of anammox microorganisms. In this study, the structure and composition of EPS (extracellular polymeric substances) were investigated to elucidate the factors for the anammox aggregation property. Anammox sludge taken from 18 lab-scale and pilot-scale reactors treating different types of wastewater was analyzed using EEM-PARAFAC (excitation-emission matrix and parallel factor analysis), FTIR (fourier transform infrared spectroscopy) and real-time PCR combined with multivariate statistical analysis. The results showed that slime and TB-EPS (tightly bound EPS) were closely related with water quality and sludge morphology, and could be used as the indicators for anammox microbial survival ability and microbial aggregate morphology. Furthermore, slime secreted from anammox bacterial cells may be exhibited higher viscosity to the sludge surface and easily formed the gel network to aggregate. Large amounts of hydrophobic groups of protein in TB-EPS promoted the microbial aggregation. The mechanisms of anammox aggregation explored in this study enhanced the understanding of anammox stability in wastewater treatment processes.

  12. How EPs Record the Voice of the Child

    ERIC Educational Resources Information Center

    Harding, Emma; Atkinson, Cathy

    2009-01-01

    Legislation, literature and research have recently advocated the importance of establishing and representing the views of children and young people. This study aimed to establish how Educational Psychologists (EPs) in one authority ascertain and present children's views in written reports. Content analysis was undertaken on the pupils' view…

  13. A Simple Updated Constitutive Model of EPS Geofoam

    NASA Astrophysics Data System (ADS)

    Leo, Chin J.; Wong, Henry K.; Liyanapathirana, Samanthika

    2010-05-01

    This paper describes an updated and simple EPS constitutive model proposed by the authors for modelling EPS geofoam in geotechnical applications where geofoam-structure as well as geofoam-soil interactions occur. The work is based on an earlier model developed by the authors, which has since been modified to reflect recent experimental results suggesting the admissibility of the Drucker-Prager failure criterion in lieu of the Mohr-Coulumb criterion. The updated model is developed within the framework of classical elasto-plasticity, with the inclusion of strain hardening, a hardening rule defined in terms of equivalent deviatoric plastic strain and a non-associate flow rule. It is simple to calibrate (with 6 independent parameters determined from triaxial tests) and is relatively easy to incorporate into numerical codes. The updated model has been calibrated against results from a series of "drained" triaxial tests performed on the EPS geofoam. The steps required for calibration are described in the paper. It has been also been shown to accurately reproduce the responses of the material under shearing, in particular, of the shear-contraction post yield behaviour typical of geofoam material. The model will be applicable for a variety of geotechnical applications such as for the modelling of EPS geofoam inclusion behind retaining structures and as a buffer material to mitigate against dynamic loading and vibrations.

  14. The ZInEP Epidemiology Survey: background, design and methods.

    PubMed

    Ajdacic-Gross, Vladeta; Müller, Mario; Rodgers, Stephanie; Warnke, Inge; Hengartner, Michael P; Landolt, Karin; Hagenmuller, Florence; Meier, Magali; Tse, Lee-Ting; Aleksandrowicz, Aleksandra; Passardi, Marco; Knöpfli, Daniel; Schönfelder, Herdis; Eisele, Jochen; Rüsch, Nicolas; Haker, Helene; Kawohl, Wolfram; Rössler, Wulf

    2014-12-01

    This article introduces the design, sampling, field procedures and instruments used in the ZInEP Epidemiology Survey. This survey is one of six ZInEP projects (Zürcher Impulsprogramm zur nachhaltigen Entwicklung der Psychiatrie, i.e. the "Zurich Program for Sustainable Development of Mental Health Services"). It parallels the longitudinal Zurich Study with a sample comparable in age and gender, and with similar methodology, including identical instruments. Thus, it is aimed at assessing the change of prevalence rates of common mental disorders and the use of professional help and psychiatric sevices. Moreover, the current survey widens the spectrum of topics by including sociopsychiatric questionnaires on stigma, stress related biological measures such as load and cortisol levels, electroencephalographic (EEG) and near-infrared spectroscopy (NIRS) examinations with various paradigms, and sociophysiological tests. The structure of the ZInEP Epidemiology Survey entails four subprojects: a short telephone screening using the SCL-27 (n of nearly 10,000), a comprehensive face-to-face interview based on the SPIKE (Structured Psychopathological Interview and Rating of the Social Consequences for Epidemiology: the main instrument of the Zurich Study) with a stratified sample (n = 1500), tests in the Center for Neurophysiology and Sociophysiology (n = 227), and a prospective study with up to three follow-up interviews and further measures (n = 157). In sum, the four subprojects of the ZInEP Epidemiology Survey deliver a large interdisciplinary database.

  15. 42 CFR 495.102 - Incentive payments to EPs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... EP's covered professional services during the payment year are determined based on claims submitted... furnishes covered professional services in more than one practice, are determined based on claims submitted... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN...

  16. EpsA is an essential gene in exopolysaccharide production in L actobacillus johnsonii FI9785

    PubMed Central

    Dertli, Enes; Colquhoun, Ian J.; Narbad, Arjan

    2015-01-01

    Summary L actobacillus johnsonii FI9785 has an eps gene cluster which is required for the biosynthesis of homopolymeric exopolysaccharides (EPS)‐1 and heteropolymeric EPS‐2 as a capsular layer. The first gene of the cluster, epsA, is the putative transcriptional regulator. In this study we showed the crucial role of epsA in EPS biosynthesis by demonstrating that deletion of epsA resulted in complete loss of both EPS‐1 and EPS‐2 on the cell surface. Plasmid complementation of the epsA gene fully restored EPS production, as confirmed by transmission electron microscopy and nuclear magnetic resonance (NMR) analysis. Furthermore, this complementation resulted in a twofold increase in the expression levels of this gene, which almost doubled amounts of EPS production in comparison with the wild‐type strain. Analysis of EPS by NMR showed an increased ratio of the heteropolysaccharide to homopolysaccharide in the complemented strain and allowed identification of the acetylated residue in EPS‐2 as the (1,4)‐linked βGlcp unit, with the acetyl group located at O‐6. These findings indicate that epsA is a positive regulator of EPS production and that EPS production can be manipulated by altering its expression. PMID:26401596

  17. Study of Double Spin Asymmetries in Inclusive ep Scattering at Jefferson Lab

    SciTech Connect

    Kang, Hoyoung

    2014-08-01

    The spin structure of the proton has been investigated in the high Bjorken x and low momentum transfer Q2 region. We used Jefferson Lab's polarized electron beam, a polarized target, and a spectrometer to get both the parallel and perpendicular spin asymmetries Apar and Aperp. These asymmetries produced the physics asymmetries A_1 and A_2 and spin structure functions g_1 and g_2. We found Q2 dependences of the asymmetries at resonance region and higher-twist effects. Our result increases the available data on the proton spin structure, especially at resonance region with low Q2. Moreover, A_2 and g_2 data show clear Q2 evolution, comparing with RSS and SANE-BETA. Negative resonance in A_2 data needs to be examined by theory. It can be an indication of very negative transverse-longitudinal interference contribution at W ~ 1.3 GeV. Higher twist effect appears at the low Q2 of 1.9 GeV2, although it is less significant than lower Q2 data of RSS. Twist03 matrix element d_2 was calculated using our asymmetry fits evaluation at Q2 – 1.9 GeV2. D-bar_2 = -0.0087±0.0014 was obtained by integrating 0.47 ≤ x ≤ 0.87.

  18. Extracellular polymeric substances (EPS) producing bacterial strains of municipal wastewater sludge: isolation, molecular identification, EPS characterization and performance for sludge settling and dewatering.

    PubMed

    Bala Subramanian, S; Yan, S; Tyagi, R D; Surampalli, R Y

    2010-04-01

    Wastewater treatment plants often face the problems of sludge settling mainly due to sludge bulking. Generally, synthetic organic polymer and/or inorganic coagulants (ferric chloride, alum and quick lime) are used for sludge settling. These chemicals are very expensive and further pollute the environment. Whereas, the bioflocculants are environment friendly and may be used to flocculate the sludge. Extracellular polymeric substances (EPS) produced by sludge microorganisms play a definite role in sludge flocculation. In this study, 25 EPS producing strains were isolated from municipal wastewater treatment plant. Microorganisms were selected based on EPS production properties on solid agar medium. Three types of EPS (slime, capsular and bacterial broth mixture of both slime and capsular) were harvested and their characteristics were studied. EPS concentration (dry weight), viscosity and their charge (using a Zetaphoremeter) were also measured. Bioflocculability of obtained EPS was evaluated by measuring the kaolin clay flocculation activity. Six bacterial strains (BS2, BS8, BS9, BS11, BS15 and BS25) were selected based on the kaolin clay flocculation. The slime EPS was better for bioflocculation than capsular EPS and bacterial broth. Therefore, extracted slime EPS (partially purified) from six bacterial strains was studied in terms of sludge settling [sludge volume index (SVI)] and dewatering [capillary suction time (CST)]. Biopolymers produced by individual strains substantially improved dewaterability. The extracted slime EPS from six different strains were partially characterized.

  19. Influence of EPS isolated from thermophilic sulphate-reducing bacteria on carbon steel corrosion.

    PubMed

    Dong, Ze Hua; Liu, Tao; Liu, Hong Fang

    2011-05-01

    Extracellular polymeric substances (EPS) were isolated by centrifugation of thermophilic sulphate-reducing bacteria (SRB) grown in API-RP38 culture medium. The protein and polysaccharide fractions were quantified and the highest concentrations were extracted from a 14-day old culture. The effect of EPS on carbon steel corrosion was investigated by electrochemical techniques. At 30°C, a small amount of EPS in 3% NaCl solution inhibited corrosion, whilst excessive amounts of EPS facilitated corrosion. In addition, the inhibition efficiency of EPS decreased with temperature due to thermal desorption of the EPS. The results suggest that adsorbed EPS layers could be beneficial to anti-corrosion by hindering the reduction of oxygen. However, the accumulation of an EPS film could stimulate the anodic dissolution of the underlying steel by chelation of Fe2+ ions.

  20. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.

    PubMed

    Boniface, Katia; Bak-Jensen, Kristian S; Li, Ying; Blumenschein, Wendy M; McGeachy, Mandy J; McClanahan, Terrill K; McKenzie, Brent S; Kastelein, Robert A; Cua, Daniel J; de Waal Malefyt, René

    2009-03-16

    Prostaglandins, particularly prostaglandin E2 (PGE2), play an important role during inflammation. This is exemplified by the clinical use of cyclooxygenase 2 inhibitors, which interfere with PGE2 synthesis, as effective antiinflammatory drugs. Here, we show that PGE2 directly promotes differentiation and proinflammatory functions of human and murine IL-17-producing T helper (Th17) cells. In human purified naive T cells, PGE2 acts via prostaglandin receptor EP2- and EP4-mediated signaling and cyclic AMP pathways to up-regulate IL-23 and IL-1 receptor expression. Furthermore, PGE2 synergizes with IL-1beta and IL-23 to drive retinoic acid receptor-related orphan receptor (ROR)-gammat, IL-17, IL-17F, CCL20, and CCR6 expression, which is consistent with the reported Th17 phenotype. While enhancing Th17 cytokine expression mainly through EP2, PGE2 differentially regulates interferon (IFN)-gamma production and inhibits production of the antiinflammatory cytokine IL-10 in Th17 cells predominantly through EP4. Furthermore, PGE2 is required for IL-17 production in the presence of antigen-presenting cells. Hence, the combination of inflammatory cytokines and noncytokine immunomodulators, such as PGE2, during differentiation and activation determines the ultimate phenotype of Th17 cells. These findings, together with the altered IL-12/IL-23 balance induced by PGE2 in dendritic cells, further highlight the crucial role of the inflammatory microenvironment in Th17 cell development and regulation.

  1. Precision measurement of sin(squared) {theta}{sub W} from {nu}-N scattering at NuTeV and direct measurements of M{sub W}

    SciTech Connect

    Yu, J. FNAL

    1998-08-01

    We present the preliminary result of sin{sup 2}{theta}{sub W} from {nu}-N deep inelastic scattering experiment, NuTeV, at Fermilab. This measurement of sin{sup 2}{theta}{sub W} comes from measuring the Paschos-Wolfenstein parameter R=({sigma}{sup {nu}}{sub NC}-{sigma}{sup {anti {nu}}}{sub NC}), using separate beams of {nu} and {anti {nu}}, utilizing the SSQT. The resulting value of sin{sup 2}{theta}{sub W}{sup on-shell} is 0.2253 {+-} 0.0019(stat) {+-} 0.0010(syst). This value is equivalent to the mass of the W boson, M{sub W} = 80.26 {+-} 0.11 GeV/c{sup 2}. We also summarize the direct measurements of M{sub W} from the Tevatron {anti p}p collider experiments, D0 and CDF. Combining these two direct measurements yields M{sub W} = 80.37 {+-} 0.08 GeV/c{sup 2}.

  2. PrEP-selected Drug Resistance Decays Rapidly After Drug Cessation

    PubMed Central

    Weis, Julie F.; Baeten, Jared M.; Mccoy, Connor O.; Warth, Chris; Donnell, Deborah; Thomas, Katherine K.; Hendrix, Craig W.; Marzinke, Mark A.; Mugo, Nelly; Matsen, Frederick A.; Celum, Connie; Lehman, Dara A.

    2015-01-01

    Objective Resistance to emtricitabine plus tenofovir disoproxil fumarate (FTC/TDF) or TDF alone used as pre-exposure prophylaxis (PrEP) has been detected in individuals who initiated PrEP during unrecognized acute HIV infection and, rarely, in PrEP breakthrough infections. PrEP-selected resistance could alter future treatment options, and therefore we sought to determine how long resistance persisted after PrEP cessation. Methods The Partners PrEP Study was a randomized placebo-controlled trial of FTC/TDF or TDF as PrEP for HIV prevention. We previously reported that PrEP-related mutations (K65R, K70E or M184IV) were detected by 454 sequencing following seroconversion in 9 individuals who acquired HIV during the Partners PrEP Study. In the current study, we used 454 sequencing to detect and quantify PrEP-related mutations in HIV RNA-positive plasma samples prior to seroconversion, as well as in plasma from 6, 12, and 24 months after PrEP cessation from these 9 individuals. Results HIV RNA-positive, antibody-negative samples were available prior to seroconversion for 4 of 9 individuals with resistance detected at seroconversion. In all 4 cases, K65R, K70E and M184IV were not detected prior to seroconversion, suggesting PrEP-related resistance was selected and not transmitted. All PrEP-selected mutations were no longer detectable by 6 months after PrEP cessation and remained undetectable at 12 and 24 months in the absence of antiretroviral therapy. Conclusion Using highly sensitive assays, PrEP-selected resistance in plasma decays below detection by six months following drug cessation and remains undetectable for ≥24 months. Even high levels of resistance mutations during acute infection decay rapidly in the absence of ongoing PrEP exposure. PMID:26731753

  3. 1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists.

    PubMed

    Zhou, Nian; Polozov, Alexandre M; O'Connell, Matthew; Burgeson, James; Yu, Peng; Zeller, Wayne; Zhang, Jun; Onua, Emmanuel; Ramirez, Jose; Palsdottir, Gudrun A; Halldorsdottir, Gudrun V; Andresson, Thorkell; Kiselyov, Alex S; Gurney, Mark; Singh, Jasbir

    2010-04-15

    A series of novel 1,7-disubstituted oxyindoles were shown to be potent and selective EP(3) receptor antagonists. Variation of substitution pattern at the C-3 position of indole enhanced in vitro metabolic stability of the resulting derivatives. Series 27a-c showed >1000-fold selectivity over a panel of prostanoid receptors including IP, FP, EP(1), EP(2) and EP(4). These agents also featured low CYP inhibition and good activity in the functional rat platelet aggregation assay.

  4. EpCAM and the biology of hepatic stem/progenitor cells.

    PubMed

    Dollé, Laurent; Theise, Neil D; Schmelzer, Eva; Boulter, Luke; Gires, Olivier; van Grunsven, Leo A

    2015-02-15

    Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein, which is frequently and highly expressed on carcinomas, tumor-initiating cells, selected tissue progenitors, and embryonic and adult stem cells. During liver development, EpCAM demonstrates a dynamic expression, since it can be detected in fetal liver, including cells of the parenchyma, whereas mature hepatocytes are devoid of EpCAM. Liver regeneration is associated with a population of EpCAM-positive cells within ductular reactions, which gradually lose the expression of EpCAM along with maturation into hepatocytes. EpCAM can be switched on and off through a wide panel of strategies to fine-tune EpCAM-dependent functional and differentiative traits. EpCAM-associated functions relate to cell-cell adhesion, proliferation, maintenance of a pluripotent state, regulation of differentiation, migration, and invasion. These functions can be conferred by the full-length protein and/or EpCAM-derived fragments, which are generated upon regulated intramembrane proteolysis. Control by EpCAM therefore not only depends on the presence of full-length EpCAM at cellular membranes but also on varying rates of the formation of EpCAM-derived fragments that have their own regulatory properties and on changes in the association of EpCAM with interaction partners. Thus spatiotemporal localization of EpCAM in immature liver progenitors, transit-amplifying cells, and mature liver cells will decisively impact the regulation of EpCAM functions and might be one of the triggers that contributes to the adaptive processes in stem/progenitor cell lineages. This review will summarize EpCAM-related molecular events and how they relate to hepatobiliary differentiation and regeneration.

  5. EpCAM and the biology of hepatic stem/progenitor cells

    PubMed Central

    Theise, Neil D.; Schmelzer, Eva; Boulter, Luke; Gires, Olivier; van Grunsven, Leo A.

    2014-01-01

    Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein, which is frequently and highly expressed on carcinomas, tumor-initiating cells, selected tissue progenitors, and embryonic and adult stem cells. During liver development, EpCAM demonstrates a dynamic expression, since it can be detected in fetal liver, including cells of the parenchyma, whereas mature hepatocytes are devoid of EpCAM. Liver regeneration is associated with a population of EpCAM-positive cells within ductular reactions, which gradually lose the expression of EpCAM along with maturation into hepatocytes. EpCAM can be switched on and off through a wide panel of strategies to fine-tune EpCAM-dependent functional and differentiative traits. EpCAM-associated functions relate to cell–cell adhesion, proliferation, maintenance of a pluripotent state, regulation of differentiation, migration, and invasion. These functions can be conferred by the full-length protein and/or EpCAM-derived fragments, which are generated upon regulated intramembrane proteolysis. Control by EpCAM therefore not only depends on the presence of full-length EpCAM at cellular membranes but also on varying rates of the formation of EpCAM-derived fragments that have their own regulatory properties and on changes in the association of EpCAM with interaction partners. Thus spatiotemporal localization of EpCAM in immature liver progenitors, transit-amplifying cells, and mature liver cells will decisively impact the regulation of EpCAM functions and might be one of the triggers that contributes to the adaptive processes in stem/progenitor cell lineages. This review will summarize EpCAM-related molecular events and how they relate to hepatobiliary differentiation and regeneration. PMID:25477371

  6. Polysulfide and bio-based EP additive performance in vegetable vs. paraffinic base oils

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Twist compression test (TCT) and 4-ball extreme pressure (EP) methods were used to investigate commercial polysulfide (PS) and bio-based polyester (PE) EP additives in paraffinic (150N) and refined soybean (SOY) base oils of similar viscosity. Binary blends of EP additive and base oil were investiga...

  7. Should Earnings per Share (EPS) Be Taught as a Means of Comparing Intercompany Performance?

    ERIC Educational Resources Information Center

    Jordan, Charles E.; Clark, Stanley J.; Smith, W. Robert

    2007-01-01

    Accounting standards state that the purpose of presenting earnings per share (EPS) is to provide financial statement users with information on the performance of a single entity. Yet, several textbook authors go further to state that EPS can be used to make comparisons among firms. In this article, the authors show that although EPS comparisons…

  8. Isolation and characterization of two exopolysaccharides produced by Lactobacillus plantarum EP56.

    PubMed

    Tallon, Richard; Bressollier, Philippe; Urdaci, Maria C

    2003-12-01

    A Lactobacillus plantarum strain producing exopolysaccharides (EPSs) was isolated from corn silage. When this strain, named L. plantarum EP56, was grown on a chemically defined medium, two EPS fractions were isolated. The cell-bound EPS fraction (EPS-b) was composed of a single high-molecular-mass polymer of 8.5x10(5) Da containing glucose, galactose and N-acetylgalactosamine in a molar ratio of approximately 3:1:1 and traces of glycerol and phosphoglycerol. The released EPS fraction (EPS-r) was composed of the high-molecular-mass bound polysaccharide and a second polymer of 4x10(4) Da containing glucose, galactose and rhamnose in a molar ratio of 3:1:1 and traces of glycerol and phosphoglycerol. EPS-b and EPS-r contained phosphate which contributes to their negative net charge. Studies on polysaccharide production and location showed that both polymers were synthesized during the exponential growth phase and that the EPS-b polymer was progressively released into the culture medium during the stationary growth phase. Carbon source and temperature influenced EPS synthesis when L. plantarum EP56 was grown in a chemically defined medium. Lactose was the most efficient carbon source among the five tested (glucose, galactose, fructose, lactose and sucrose). EPS production was also increased when the incubation temperature is lowered.

  9. 30 CFR 250.228 - What administrative information must accompany the EP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What administrative information must accompany the EP? 250.228 Section 250.228 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Contents of Exploration Plans (ep) § 250.228 What administrative information must accompany the EP?...

  10. 30 CFR 250.223 - What mitigation measures information must accompany the EP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What mitigation measures information must accompany the EP? 250.223 Section 250.223 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Contents of Exploration Plans (ep) § 250.223 What mitigation measures information must accompany the EP?...

  11. The Role of Healthcare Providers in the Roll-Out of PrEP

    PubMed Central

    Krakower, Douglas S.; Mayer, Kenneth H.

    2015-01-01

    Purpose of Review To review the most recent studies assessing the preparedness of healthcare practitioners to provide anti-HIV pre-exposure prophylaxis (PrEP) and to suggest areas for future implementation research. Recent Findings As PrEP is a bio-behavioral intervention, healthcare providers are likely to play a critical role in implementing PrEP in care settings. Studies suggest that many specialized providers are aware of PrEP and support its provision as a public health intervention, though knowledge and acceptance are less among generalists. Therefore, utilization of PrEP by clinicians has been limited to a few early adopters. Concerns about the efficacy and long-term safety of PrEP, and perceived barriers to prescribing PrEP, could limit prescribing behaviors and intentions. Resistance to performing routine HIV risk assessments by clinicians is an additional barrier to implementing PrEP, though innovative tools to help clinicians routinely perform risk assessments are being developed. Summary Interventions are needed to engage a broader array of healthcare providers in PrEP provision. Utilizing a framework based on diffusion of innovation theory, this review proposes strategies that can be implemented and evaluated to increase PrEP prescribing by healthcare providers. If resources are invested in training clinicians to provide PrEP, then these stakeholders could enhance the use of PrEP as part of a prevention package by primary providers. PMID:26417953

  12. 30 CFR 250.285 - How do I submit revised and supplemental EPs, DPPs, and DOCDs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false How do I submit revised and supplemental EPs....285 How do I submit revised and supplemental EPs, DPPs, and DOCDs? (a) Submittal. You must submit to the Regional Supervisor any revisions and supplements to approved EPs, DPPs, or DOCDs for...

  13. 30 CFR 250.285 - How do I submit revised and supplemental EPs, DPPs, and DOCDs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I submit revised and supplemental EPs... supplemental EPs, DPPs, and DOCDs? (a) Submittal. You must submit to the Regional Supervisor any revisions and supplements to approved EPs, DPPs, or DOCDs for approval, whether you initiate them or the Regional...

  14. 42 CFR 495.10 - Participation requirements for EPs, eligible hospitals, and CAHs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Participation requirements for EPs, eligible... HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM General Provisions § 495.10 Participation requirements for EPs... incentive payment reassignments. (1) EPs are permitted to reassign their incentive payments to...

  15. 7 CFR 3201.53 - Expanded polystyrene (EPS) foam recycling products.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Expanded polystyrene (EPS) foam recycling products... FOR FEDERAL PROCUREMENT Designated Items § 3201.53 Expanded polystyrene (EPS) foam recycling products... with this part, will give a procurement preference for qualifying biobased EPS foam recycling...

  16. 7 CFR 3201.53 - Expanded polystyrene (EPS) foam recycling products.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Expanded polystyrene (EPS) foam recycling products... FOR FEDERAL PROCUREMENT Designated Items § 3201.53 Expanded polystyrene (EPS) foam recycling products... with this part, will give a procurement preference for qualifying biobased EPS foam recycling...

  17. 7 CFR 3201.53 - Expanded polystyrene (EPS) foam recycling products.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Expanded polystyrene (EPS) foam recycling products... FOR FEDERAL PROCUREMENT Designated Items § 3201.53 Expanded polystyrene (EPS) foam recycling products... with this part, will give a procurement preference for qualifying biobased EPS foam recycling...

  18. 7 CFR 2902.53 - Expanded polystyrene (EPS) foam recycling products.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Expanded polystyrene (EPS) foam recycling products... FEDERAL PROCUREMENT Designated Items § 2902.53 Expanded polystyrene (EPS) foam recycling products. (a..., will give a procurement preference for qualifying biobased EPS foam recycling products. By that...

  19. 30 CFR 250.222 - What lease stipulations information must accompany the EP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What lease stipulations information must accompany the EP? 250.222 Section 250.222 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Contents of Exploration Plans (ep) § 250.222 What lease stipulations information must accompany the EP?...

  20. 42 CFR 495.10 - Participation requirements for EPs, eligible hospitals, and CAHs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... manner specified by CMS its CMS Certification Number (CCN) and its Taxpayer Identification Number (TIN... Number (TIN) which may be the EP's Social Security Number (SSN) to which the EP's incentive payment... CFR part 424 subpart F. (ii) Medicaid EPs may also assign their incentive payments to a TIN for...

  1. 42 CFR 495.10 - Participation requirements for EPs, eligible hospitals, and CAHs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... manner specified by CMS its CMS Certification Number (CCN) and its Taxpayer Identification Number (TIN... Number (TIN) which may be the EP's Social Security Number (SSN) to which the EP's incentive payment... CFR part 424 subpart F. (ii) Medicaid EPs may also assign their incentive payments to a TIN for...

  2. PrEP in Europe – expectations, opportunities and barriers

    PubMed Central

    McCormack, Sheena Mary; Noseda, Veronica; Molina, Jean-Michel

    2016-01-01

    Introduction In contrast to the global trend showing a decline in new HIV infections, the number reported in the World Health Organization (WHO) region of Europe is increasing. Health systems are disparate, but even countries with free access to screening and treatment observe continuing high rates of new infections in key populations, notably men who have sex with men (MSM). Pre-exposure prophylaxis (PrEP) is only available in France. This commentary describes the European epidemics and healthcare settings where PrEP could be delivered, how need might be estimated for MSM and the residual barriers to access. Discussion Health systems and government commitment to HIV prevention and care, both financial and political, differ considerably between the countries that make up Europe. A common feature is that funds for prevention are a small fraction of funds for care. Although care is generally good, access is limited in the middle-income countries of Eastern Europe and central Asia, and only 19% of people living with HIV received antiretroviral therapy in 2014. It is challenging to motivate governments or civil society to implement PrEP in the context of this unmet treatment need, which is driven by limited national health budgets and diminishing assistance from foreign aid. The high-income countries of Western Europe have hesitated to embrace PrEP for different reasons, initially due to key gaps in the evidence. Now that PrEP has been shown to be highly effective in European MSM in two randomized controlled trials, it is clear that the major barrier is the cost of the drug which is still on patent, although inadequate health systems and diminishing investment in civil society are also key challenges to overcome. Conclusions The momentum to implement PrEP in European countries is increasing and provides a welcome opportunity to expand and improve clinical services and civil society support focused on HIV and related infections including other sexually transmitted and

  3. Nonperturbative short-range dynamics in TMDs

    SciTech Connect

    Weiss, Christian

    2013-05-01

    This presentation covers: deep inelastic processes and transverse momentum distributions; chiral symmetry breaking, including the physical picture, the dynamical model, and parton distributions; partonic structures, including transverse momentum distributions, coordinate space correlator, and short range correlations; and measurements of semi-inclusive deep inelastic scattering, correlations, and multi-parton processes in pp interactions.

  4. Soft color screening effects in diffractive DIS

    SciTech Connect

    Pasechnik, Roman; Enberg, Rikard; Ingelman, Gunnar

    2011-07-15

    We construct a QCD-based model where soft gluon rescattering between final state partons in deep inelastic scattering leads to events with large rapidity gaps and a leading proton. The model successfully describes the precise HERA data on the diffractive deep inelastic structure function in the whole available kinematical range.

  5. A Maladaptive Role for EP4 Receptors in Mouse Mesangial Cells

    PubMed Central

    Yang, Guang-xia; Xu, Yu-yin; Fan, Ya-ping; Wang, Jing; Chen, Xiao-lan; Zhang, Yi-de; Wu, Jian-hua

    2014-01-01

    Roles of the prostaglandin E2 E-prostanoid 4 receptor (EP4) on extracellular matrix (ECM) accumulation induced by TGF-β1 in mouse glomerular mesangial cells (GMCs) remain unknown. Previously, we have identified that TGF-β1 stimulates the expression of FN and Col I in mouse GMCs. Here we asked whether stimulation of EP4 receptors would exacerbate renal fibrosis associated with enhanced glomerular ECM accumulation. We generated EP4Flox/Flox and EP4+/− mice, cultured primary WT, EP4Flox/Flox and EP4+/− GMCs, AD-EP4 transfected WT GMCs (EP4 overexpression) and AD-Cre transfected EP4Flox/Flox GMCs (EP4 deleted). We found that TGF-β1-induced cAMP and PGE2 synthesis decreased in EP4 deleted GMCs and increased in EP4 overexpressed GMCs. Elevated EP4 expression in GMCs augmented the coupling of TGF-β1 to FN, Col I expression and COX2/PGE2 signaling, while TGF-β1 induced FN, Col I expression and COX2/PGE2 signaling were down-regulated in EP4 deficiency GMCs. 8 weeks after 5/6 nephrectomy (Nx), WT and EP4+/− mice exhibited markedly increased accumulation of ECM compared with sham-operated controls. Albuminuria, blood urea nitrogen and creatinine (BUN and Cr) concentrations were significantly increased in WT mice as compared to those of EP4+/− mice. Urine osmotic pressure was dramatically decreased after 5/6 Nx surgery in WT mice as compared to EP4+/− mice. The pathological changes in kidney of EP4+/− mice was markedly alleviated compared with WT mice. Immunohistochemical analysis showed significant reductions of Col I and FN in the kidney of EP4+/− mice compared with WT mice. Collectively, this investigation established EP4 as a potent mediator of the pro-TGF-β1 activities elicited by COX2/PGE2 in mice GMCs. Our findings suggested that prostaglandin E2, acting via EP4 receptors contributed to accumulation of ECM in GMCs and promoted renal fibrosis. PMID:25122504

  6. The quantum nature of the OH stretching mode in ice and water probed by neutron scattering experiments

    SciTech Connect

    Senesi, Roberto; Flammini, Davide; Kolesnikov, Alexander I; Murray, Eamonn D.; Galli, Giulia; Andreani, Carla

    2013-01-01

    The OH stretching vibrational spectrum of water was measured in a wide range of temperatures across the triple point, 269 K < T < 296 K, using Inelastic Neutron Scattering (INS). The hydrogen projected density of states and the proton mean kinetic energy, _OH, were determined for the first time within the framework of a harmonic description of the proton dynamics. We found that in the liquid the value of _OH is nearly constant as a function of T, indicating that quantum effects on the OH stretching frequency are weakly dependent on temperature. In the case of ice, ab initio electronic structure calculations, using non-local van der Waals functionals, provided _OH values in agreement with INS experiments. We also found that the ratio of the stretching (_OH) to the total (_exp) kinetic energy, obtained from the present measurements, increases in going from ice, where hydrogen bonding is the strongest, to the liquid at ambient conditions and then to the vapour phase, where hydrogen bonding is the weakest. The same ratio was also derived from the combination of previous deep inelastic neutron scattering data, which does not rely upon the harmonic approximation, and the present measurements. We found that the ratio of stretching to the total kinetic energy shows a minimum in the metastable liquid phase. This finding suggests that the strength of intermolecular interactions increases in the supercooled phase, with respect to that in ice, contrary to the accepted view that supercooled water exhibits weaker hydrogen bonding than ice.

  7. The effect of deletion of cyclooxygenase-2, prostaglandin receptor EP2, or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell lines.

    PubMed

    Ono, Katsuhiro; Akatsu, Takuhiko; Kugai, Nobuo; Pilbeam, Carol C; Raisz, Lawrence G

    2003-11-01

    The inducible prostaglandin (PG) synthesis enzyme, cyclooxygenase-2 (COX-2), is involved in osteoclast (OC) formation in cocultures of mouse mammary cancer cell lines (MMT060562 or BALB/c-MC) and bone marrow cells through production of PGE(2). There are four PGE(2) receptors but only the EP2 and EP4 receptors are reported to be important for OC formation. We have investigated the role of COX-2, EP2 receptor, and EP4 receptor in marrow cells for osteoclastogenesis in cocultures of cancer cells and bone marrow cells. We cocultured cancer cell lines with bone marrow cells from COX-2 knockout (-/-), EP2 -/- or EP4 -/- mice compared to wild-type mice. In addition, an EP4 receptor antagonist (EP4 RA) was added in some cocultures. Disruption of COX-2 gene in bone marrow cells had no effect on PGE(2) production and OC formation in cocultures with MMT060562, while it abrogated PGE(2) production and OC formation in cocultures with BALB/c-MC. Disruption of the EP2 gene in bone marrow cells had no effect on OC formation in the cocultures, while disruption of the EP4 gene in bone marrow cells abrogated OC formation in the cocultures. Furthermore, EP4 RA suppressed OC formation and prevented the increase in receptor activator of nuclear factor kappaB ligand (RANKL) mRNA levels in the cocultures. We conclude that COX-2 in cancer cells is responsible for PGE(2) and OC production in cocultures with MMT060562, while COX-2 in bone marrow cells, not cancer cells, is responsible for PGE(2) and OC production in cocultures with BALB/c-MC, and EP4 receptors are essential for OC formation in both cocultures.

  8. Association of EP2 receptor and SLC19A3 in regulating breast cancer metastasis

    PubMed Central

    Cheuk, Isabella W; Shin, Vivian Y; Siu, Man T; Tsang, Julia Y; Ho, John C; Chen, Jiawei; Tse, Gary M; Wang, Xian; Kwong, Ava

    2015-01-01

    Breast cancer is the most common cancer in women worldwide. Triple-negative breast cancer patients have higher metastatic rate than patients with other breast cancer subtypes. Distant metastasis is one of the causes leading to the high mortality rates. Cyclooxygenase-2 (COX2) is associated with breast cancer metastasis and the downstream prostaglandin E2 (PGE2) exerted its effect through EP receptors (EP1-EP4). However, the exact molecular events of EP receptors in breast cancer metastasis remain undefined. Expressions of EP receptors were determined during cancer development in NOD-SCID mice inoculated with MB-231 and MB-231-EP2 clone. EP2 overexpressing stable clone was constructed to investigate the proliferation and invasion potentials in vivo and in vitro. Drug transporter array was used to identify EP2 receptor-associated drug transported genes in breast cancer metastasis. Localization of EP2 receptor in primary tissues and xenografts were examined by immunostaining. Stable EP2-expression cells formed larger tumors than parental cells in mice model and was highly expressed in both primary and metastatic tissues. Silencing of EP2 receptor by siRNA and antagonist (AH 6809) significantly decreased cell proliferation and invasion, concomitant with reduced MMP-2 and MMP-9 expressions. Results from array data showed that expression of SLC19A3 was markedly increased in EP2 siRNA transfected cells. Ectopic expression of SLC19A3 retarded cell proliferation, invasion and MMPs expressions. Notably, SLC19A3 had a lower expression in primary tissues and was negatively correlated with EP2 receptor expression. Our novel finding revealed that EP2 receptor regulated metastasis through downregulation of SLC19A3. Thus, targeting EP2-SLC19A3 signaling is a potential therapeutic therapy for treating metastatic breast cancer. PMID:26807319

  9. Expanded polystyrene (EPS) floats for surveillance of Ochlerotatus japonicus.

    PubMed

    Scott, Jamesina J; Crans, Wayne J

    2003-12-01

    Blocks of expanded polystyrene (EPS) were placed in a variety of habitats to investigate their potential as an egg-collection device for container-dwelling Aedes and Ochlerotatus species. Eggs from Ochlerotatus japonicus, Oc. triseriatus, Oc. hendersoni, and Aedes albopictus were collected with EPS floats. The float provides an inexpensive, low-maintenance alternative to the Centers for Disease Control ovitrap for sampling container-dwelling mosquito species that are important vectors of disease. Eggs collected on the floats have many potential applications, including use in routine population surveillance; detection of Oc. japonicus, Ae. albopictus, and other container-dwelling species in new areas; species distribution studies; natural transovarial transmission studies; ovipositional studies; collection of local field populations for insecticide resistance assays; assessment of adulticiding efficacy; and establishment of new laboratory colonies.

  10. High-Z Coating Experiments on Omega EP

    NASA Astrophysics Data System (ADS)

    Karasik, Max; Oh, J.; Stoeckl, C.; Schmitt, A. J.; Aglitskiy, Y.; Obenschain, S. P.

    2016-10-01

    Previous experiments on Nike KrF laser (λ=248nm) at NRL found that a thin (400-800 Å) high-Z (Au or Pd) overcoat on the target is effective in suppressing broadband imprint. Implementation of this technique on the tripled Nd:glass (351nm) NIF would enable higher uniformity direct-drive experiments there. To this end, we are carrying out experiments using the NIF-like beams of Omega EP. On Nike, a low-intensity, highly smooth prepulse heats and pre-expands the low thermal mass metallic coating to 100 um scale length. This likely improves imprint reduction for longer spatial scales because of increased distance between laser absorption and the ablation surface. The 3 ω beams of Omega EP do not have this feature due to nonlinear harmonic conversion. We introduced a means of pre-expanding the high-Z coating to similar length scale on Omega EP using a soft x-ray prepulse, generated by irradiating an auxiliary Au foil 1cm in front of the main target tens of ns prior to the main target drive. Coating dynamics are measured using side-on radiography. The effectiveness of pre-expansion on imprint reduction will be assessed by measurements of the RT-amplified imprint using monochromatic curved crystal radiography. Work supported by the Department of Energy/NNSA.

  11. Implications of HIV PrEP Trials Results

    PubMed Central

    Anton, Peter; Fletcher, Courtney V.; DeGruttola, Victor; McGowan, Ian; Becker, Stephen; Zwerski, Sheryl; Burns, David

    2011-01-01

    Abstract Six randomized clinical trials have been implemented to examine the efficacy of tenofovir disoproxil fumarate (TDF) and/or TDF/emtricitabine (TDF/FTC) as preexposure prophylaxis for HIV-1 infection (PrEP). Although largely complementary, the six trials have many similar features. As the earliest results become available, an urgent question may arise regarding whether changes should be made in the conduct of the other trials. To consider this in advance, a Consultation on the Implications of HIV Pre-Exposure Prophylaxis (PrEP) Trials Results sponsored by the Division of AIDS (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), and the Bill and Melinda Gates Foundation (BMGF) was held on January 29, 2010, at the Natcher Conference Center, NIH, Bethesda, MD. Participants included basic scientists, clinical researchers (including investigators performing the current PrEP trials), and representatives from the U.S. Food and Drug Administration (FDA) and the agencies sponsoring the trials: the U.S. Centers for Disease Control and Prevention (CDC), the U.S. Agency for International Development (USAID), the BMGF, and the U.S. NIH. We report here a summary of the presentations and highlights of salient discussion topics from this workshop. PMID:20969483

  12. The Ep - Eiso relation and the internal shock model

    NASA Astrophysics Data System (ADS)

    Mochkovitch, R.; Nava, L.

    2015-05-01

    Context. The validity of the Ep - Eiso correlation in gamma-ray bursts and the possibility of explaining the prompt emission with internal shocks are highly debated questions. Aims: We study whether the Ep - Eiso correlation can be reproduced if internal shocks are indeed responsible for the prompt emission, or conversely, if the correlation can be used to constrain the internal shock scenario. Methods: We developed a toy model where internal shocks are limited to the collision of only two shells. Synthetic burst populations were constructed for various distributions of the model parameters, such as the injected power in the relativistic outflow, the average Lorentz factor, and its typical contrast between the shells. These parameters can be independent or linked by various relations. Results: Synthetic Ep - Eiso diagrams are obtained in the different cases and compared with the observed correlation. The reference observed correlation is the one defined by the BAT6 sample, a sample of Swift bursts almost complete in redshift and affected by well-known and reproducible instrumental selection effects. The comparison is then performed with a subsample of synthetic bursts that satisfy the same selection criteria as were imposed on the BAT6 sample. A satisfactory agreement between model and data can often be achieved, but only if several strong constraints are satisfied on both the dynamics of the flow and the microphysics that governs the redistribution of the shock-dissipated energy.

  13. EP-toxicity testing of mercury removal resin grout

    SciTech Connect

    Mersman, K.E.

    1984-07-18

    To determine which category a waste will fit into, the EPA requires a classification test. The test, EP-toxicity, consists of a physical integrity test followed by an extraction. For the case of the mercury removal resin grout, the mercury concentration in the extract cannot exceed 0.2 mg/L if the waste is to be classified as ``solid waste.`` Otherwise, the waste is classified as ``hazardous.`` Simulated process solutions were used to load the mercury removal resin. The resin was solidified with the addition of cement and water using a formulation based on grout formulations typically used to solidify power reactor ion exchange resins. Envirodyne Engineers of St. Louis, Missouri, an EPA sanctioned laboratory, performed the EP-toxicity test for the two samples. One sample was a blank which was made with unloaded resin. For the formulation tested, the EP-toxicity test results showed that the mercury removal resin grout does not fit into the ``hazardous waste`` category.

  14. Implications of HIV PrEP trials results.

    PubMed

    Veronese, Fulvia; Anton, Peter; Fletcher, Courtney V; DeGruttola, Victor; McGowan, Ian; Becker, Stephen; Zwerski, Sheryl; Burns, David

    2011-01-01

    Abstract Six randomized clinical trials have been implemented to examine the efficacy of tenofovir disoproxil fumarate (TDF) and/or TDF/emtricitabine (TDF/FTC) as preexposure prophylaxis for HIV-1 infection (PrEP). Although largely complementary, the six trials have many similar features. As the earliest results become available, an urgent question may arise regarding whether changes should be made in the conduct of the other trials. To consider this in advance, a Consultation on the Implications of HIV Pre-Exposure Prophylaxis (PrEP) Trials Results sponsored by the Division of AIDS (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), and the Bill and Melinda Gates Foundation (BMGF) was held on January 29, 2010, at the Natcher Conference Center, NIH, Bethesda, MD. Participants included basic scientists, clinical researchers (including investigators performing the current PrEP trials), and representatives from the U.S. Food and Drug Administration (FDA) and the agencies sponsoring the trials: the U.S. Centers for Disease Control and Prevention (CDC), the U.S. Agency for International Development (USAID), the BMGF, and the U.S. NIH. We report here a summary of the presentations and highlights of salient discussion topics from this workshop.

  15. Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.

    PubMed

    Honda, A; Sugimoto, Y; Namba, T; Watabe, A; Irie, A; Negishi, M; Narumiya, S; Ichikawa, A

    1993-04-15

    A functional cDNA clone encoding mouse EP2 subtype of prostaglandin (PG) E receptor was isolated from a mouse cDNA library by cross-hybridization with the mouse EP3 subtype PGE receptor cDNA. The mouse EP2 receptor consists of 513 amino acid residues with putative seven-transmembrane domains. In contrast to EP3 receptor, this receptor possesses long third intracellular loop and carboxyl-terminal tail. [3H] PGE2 specifically bound to the membrane of mammalian COS cells transfected with the cDNA. The binding to the membrane was displaced with unlabeled PG in the order of PGE2 = PGE1 > iloprost > or = PGF2 alpha > or = PGD2. The binding was also inhibited by misoprostol, an EP2 and EP3 agonist, but not by sulprostone, an EP1 and EP3 agonist, and SC-19220, an EP1 antagonist. PGE2 markedly increased cAMP level in COS cells transfected with the cDNA. These results suggest that this receptor is EP2 subtype. Northern blot analysis demonstrated that the EP2 mRNA is widely expressed in various tissues, the abundant expression being observed in ileum, thymus, and mastocytoma P-815 cells.

  16. HIV-negative male couples' attitudes about pre-exposure prophylaxis (PrEP) and using PrEP with a sexual agreement.

    PubMed

    Mitchell, Jason W; Lee, Ji-Young; Woodyatt, Cory; Bauermeister, José; Sullivan, Patrick; Stephenson, Rob

    2016-08-01

    One efficacious strategy to help prevent HIV is oral pre-exposure prophylaxis (PrEP), a daily regimen of antiretroviral treatment taken by HIV-negative individuals. Two of the recommendations of Centers for Disease Control and Prevention (CDC) guidelines for PrEP pertain to being in a relationship (i.e., male couples). Despite the recognition of how primary partners in male couples' relationships shape HIV risk and CDC's PrEP guidelines, there is a paucity of data that examine HIV-negative male couples' attitudes toward PrEP use and using PrEP with a sexual agreement. A sexual agreement is an explicit agreement made between two individuals about what sex and other related behaviors may occur within and outside of their relationship. In this qualitative study, we examine HIV-negative male couples' attitudes toward PrEP use and whether they thought PrEP could be integrated into a sexual agreement. Data for this study are drawn from couple-level interviews conducted in 2014 with 29 HIV-negative male couples who had a sexual agreement and were from Atlanta or Detroit. Both passive (e.g., flyers) and active (e.g., targeted Facebook advertisements) recruitment methods were used; the sample was stratified by agreement type. Thematic analysis was applied to identify the following themes regarding HIV-negative male couples' attitudes toward PrEP use: (1) PrEP and condom use; (2) concerns about PrEP (e.g., effectiveness, side effects, and promoting sexually risky behavior); and (3) accessibility of PrEP. Some thought PrEP could be a part of couples' agreement because it could help reduce sexual anxiety and sexual risk, and would help keep the couple safe. Others described PrEP use with an agreement as something for "others". Some were also concerned that incorporating PrEP could usurp the need for a sexual agreement in a couples' relationship. These themes highlight the need to improve informational messaging and promotion efforts about PrEP among HIV-negative male couples

  17. The Angular Momentum Structure of the Nucleon

    SciTech Connect

    Nowak, Wolf-Dieter

    2008-10-13

    The proton spin budget is discussed. Results are presented from inclusive and semi-inclusive deep inelastic scattering and from deeply virtual Compton scattering. They permit interpretations towards the determination of various contributions to the proton spin.

  18. Prostaglandin receptor EP2 mediates PGE2 stimulated hypercalcemia in mice in vivo.

    PubMed

    Li, Xiaodong; Tomita, Masato; Pilbeam, Carol C; Breyer, Richard M; Raisz, Lawrence G

    2002-04-01

    Prostaglandin E2 (PGE2) can stimulate bone resorption by a cyclic AMP-dependent pathway. Two PGE2 receptors, EP2 and EP4 have been shown to play a role in PGE2 stimulation of osteoclast formation. In primary osteoblastic cell cultures from EP2 wild type (EP2 +/+) mice, PGE2 (0.1 microM) increased cyclic AMP production 3.5-fold, but PGE2 had no effect on cells from mice in which the EP2 receptor had been deleted (EP2 -/-). To examine the role of the EP2 receptor in the resorption response in vivo we injected PGE2 in EP2 -/- mice, and compared them with EP2 +/+ mice. Injection of PGE2 (3 mg/kg, four times daily for three days) in 9- to 12-month-old male mice on a 129 SvEv background increased serum calcium from 9.8 +/- 0.5 to 10.7 +/- 0.3 mg/dl (P < 0.01) in EP2 +/+ mice but not in EP2 -/- mice (10.1 +/- 0.3 vs. 10.2 +/- 0.3 mg/dl). PGE2 injection (6 mg/kg twice a day for three days) in 3-4 month old male mice on a C57 BL/6 X 129 SvEv background increased calcium from 8.2 +/- 0.1 to 9.0 +/- 0.3 mg/dl (P < 0.05) in EP2 +/+ mice but had no effect in EP2-/- mice (8.4 +/- 0.1 vs. 8.3 +/- 0.2 mg/dl). Injection of PGE2 over the calvariae of EP2 +/+ and EP2-/- mice increased the expression of receptor activator of nuclear factor kappaB ligand (RANKL) both locally and in the tibia, but RANKL responses were lower in EP2 -/- mice. We conclude that EP2 receptor plays a role in the hypercalcemic response to PGE2. This impaired response in EP2 -/- mice may be due to decreased ability to stimulate cyclic AMP and in part, to a smaller increase in the expression of RANKL mRNA.

  19. Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype.

    PubMed

    Hibbs, T A; Lu, B; Smock, S L; Vestergaard, P; Pan, L C; Owen, T A

    1999-05-01

    Prostaglandin E2 (PGE2) binds to four G-protein coupled cell surface receptors (EP1-EP4) and has been implicated as a local mediator of bone anabolism via a cyclic AMP mediated pathway following activation of the EP2 and/or EP4 receptor subtype. A canine kidney cDNA library was screened using a human EP2 probe, and a clone with an open reading frame of 1083 bp, potentially encoding a protein of 361 amino acids, was characterized. This open reading frame has 89% identity to the human EP2 cDNA at the nucleotide level and 87% identity at the predicted protein level. Scatchard analysis of a CHO cell line stably transfected with canine EP2 yielded a dissociation constant of 22 nM for PGE2. Competition binding studies, using 3H-PGE2 as ligand, demonstrated specific displacement by PGE2, Prostaglandin E1, Prostaglandin A3, and butaprost (an EP2 selective ligand), but not by ligands with selectivity for the related DP, FP, IP, or TP receptors. Specific ligand binding also resulted in increased levels of cAMP in EP2 transfected cells with no evidence of short-term, ligand-induced desensitization. Northern blot analysis revealed two transcripts of 3300 and 2400 bp in canine lung, and reverse-transcription polymerase chain reaction showed expression in all tissues examined. Southern blot analysis suggests the presence of a single-copy gene for EP2 in the dog.

  20. Characteristics of extracellular polymeric substances (EPS) fractions from excess sludges and their effects on bioflocculability.

    PubMed

    Yu, Guang-Hui; He, Pin-Jing; Shao, Li-Ming

    2009-07-01

    Extracellular polymeric substances (EPS) of biological origin are ubiquitous in excess sludges and can be applied as an underlying bioflocculant, owing to their high content of macromolecules and cations. However, low flocculating activity limits the feasibility of their practical applications. This study provides a novel EPS fractionation approach to improve their flocculability by extracting an active EPS fraction and removing the others with low flocculability. The results showed that for two excess sludges (called sludge A and sludge B), the tightly bound EPS (TB-EPS) fraction possessed a high flocculating rate to kaolin suspension compared with the other EPS fractions [i.e., supernatant, slime, and loosely bound EPS (LB-EPS) fraction] (>54.1+/-1.4% vs <7.8+/-1.6%). High bioflocculability of TB-EPS fraction could be attributable to high contents of macromolecules (330-1200 kDa) and trivalent cations (Fe(3+) and Al(3+)). Further investigation reveals that the TB-EPS fraction caused aggregation of particles by bridging and sweep flocculation.

  1. Composition and aggregation of extracellular polymeric substances (EPS) in hyperhaline and municipal wastewater treatment plants

    PubMed Central

    Zeng, Jie; Gao, Jun-Min; Chen, You-Peng; Yan, Peng; Dong, Yang; Shen, Yu; Guo, Jin-Song; Zeng, Ni; Zhang, Peng

    2016-01-01

    As important constituents of activated sludge flocs, extracellular polymeric substances (EPS) play significant roles in pollutants adsorption, the formation and maintenance of microbial aggregates, and the protection of microbes from external environmental stresses. In this work, EPS in activated sludge from a municipal wastewater treatment plant (M-WWTP) with anaerobic/anoxic/oxic (A2/O) process and a hyperhaline wastewater treatment plant (H-WWTP) with anaerobic/oxic (A/O) process were extracted by ultrasound method. The proteins and polysaccharides contents in EPS were determined by using a modified Lowry method and anthrone colorimetry respectively to analyze the detail differences in two types of WWTPs. Fourier transform-infrared spectroscopy and three-dimensional excitation-emission matrix fluorescence spectroscopy demonstrated proteins and polysaccharides were the dominant components of the two types of EPS, and the aromatic protein-like substances accounted for a larger proportion in EPS proteins. The results of the aggregation test indicated that EPS were good for the sludge aggregation, and the EPS in oxic sludge were more beneficial to sludge aggregation than that in anoxic sludge. Anoxic sludge EPS in H-WWTP showed a negligible effect on sludge aggregation. Comparative study on EPS of different tanks in the M-WWTP and H-WWTP was valuable for understanding the characteristics of EPS isolated from two typical wastewater treatment processes. PMID:27220287

  2. E-type prostanoid receptor 4 (EP4) in disease and therapy

    PubMed Central

    Konya, Viktoria; Marsche, Gunther; Schuligoi, Rufina; Heinemann, Akos

    2013-01-01

    The large variety of biological functions governed by prostaglandin (PG) E2 is mediated by signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse strains with genetic ablation of each EP receptor subtype and the development of selective EP agonists and antagonists have tremendously advanced our understanding of PGE2 as a physiologically and clinically relevant mediator. Moreover, studies using disease models revealed numerous conditions in which distinct EP receptors might be exploited therapeutically. In this context, the EP4 receptor is currently emerging as most versatile and promising among PGE2 receptors. Anti-inflammatory, anti-thrombotic and vasoprotective effects have been proposed for the EP4 receptor, along with its recently described unfavorable tumor-promoting and pro-angiogenic roles. A possible explanation for the diverse biological functions of EP4 might be the multiple signaling pathways switched on upon EP4 activation. The present review attempts to summarize the EP4 receptor-triggered signaling modules and the possible therapeutic applications of EP4-selective agonists and antagonists. PMID:23523686

  3. Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor development.

    PubMed

    Sung, Y M; He, G; Hwang, D H; Fischer, S M

    2006-09-07

    We previously showed that the EP2 knockout mice were resistant to chemically induced skin carcinogenesis. The purpose of this study was to investigate the role of the overexpression of the EP2 receptor in mouse skin carcinogenesis. To determine the effect of overexpression of EP2, we used EP2 transgenic (TG) mice and wild-type (WT) mice in a DMBA (7,12-dimethylbenz[alpha]anthracene)/TPA (12-O-tetradecanoylphorbol-13-acetate) two-stage carcinogenesis protocol. EP2 TG mice developed significantly more tumors compared with WT mice. Overexpression of the EP2 receptor increased TPA-induced keratinocyte proliferation both in vivo and in vitro. In addition, the epidermis of EP2 TG mice 48 h after topical TPA treatment was significantly thicker compared to that of WT mice. EP2 TG mice showed significantly increased cyclic adenosine monophosphate levels in the epidermis after prostaglandin E2 (PGE2) treatment. The inflammatory response to TPA was increased in EP2 TG mice, as demonstrated by an increased number of macrophages in the dermis. Tumors and 7 x TPA-treated and DMBA-TPA-treated (6 weeks) skins from EP2 TG mice produced more blood vessels than those of WT mice as determined by CD-31 immunostaining. Vascular endothelial growth factor (VEGF) protein expression was significantly increased in squamous cell carcinoma (SCC) samples from EP2 TG mice compared that of WT mice. There was, however, no difference in the number of apoptotic cells in tumors from WT and EP2 TG mice. Together, our results suggest that the overexpression of the EP2 receptor plays a significant role in the protumorigenic action of PGE2 in mouse skin.

  4. Understanding HIV Care Provider Attitudes Regarding Intentions to Prescribe PrEP

    PubMed Central

    Castel, Amanda D.; Feaster, Daniel J.; Tang, Wenze; Willis, Sarah; Jordan, Heather; Villamizar, Kira; Kharfen, Michael; Kolber, Michael A.; Rodriguez, Allan; Metsch, Lisa

    2015-01-01

    Introduction Pre-exposure prophylaxis (PrEP) is a promising approach to reducing HIV incidence. Thus garnering the support of HIV providers, who are most familiar with antiretrovirals and likely to encounter patients in HIV serodiscordant relationships, to scale-up PrEP implementation is essential. We sought to determine whether certain subgroups of HIV providers were more likely to intend to prescribe PrEP. Methods Surveys were administered to HIV providers in Miami, Florida and Washington, DC. Composite scores were developed to measure PrEP knowledge, experience, and likelihood of prescribing. Latent class analysis (LCA) was used to stratify provider attitudes toward PrEP. Results Among 142 HIV providers, 73.2% had cared for more than 20 HIV-infected patients in the prior 3 months; 17% had ever prescribed PrEP. LCA identified two classes of providers (entropy 0.904); Class 1 (n=95) found PrEP less effective and perceived barriers to prescribing it; Class 2 (n=47) perceived PrEP as moderately effective and perceived fewer barriers to prescribing it. Compared to Class 2, Class 1 had significantly less experience with PrEP delivery (t(22.7)=2.88, p=0.009) and was significantly less likely to intend to prescribe to patients with multiple sex partners (20% vs. 43%, p=0.04) and those with a drug use history (7% vs. 24%, p=0.001). Conclusions While most HIV providers found PrEP to be effective, those considering it less effective had limited knowledge and experience with PrEP and had lesser intentions to prescribe. Provider training regarding whom should receive PrEP and addressing potential barriers to PrEP provision are needed if this HIV prevention method is to be optimized. PMID:26247895

  5. Development of the HyStEP Device

    SciTech Connect

    Johnson, Terry A.; Ainscough, Christopher; Terlip, Danny; Meadows, Graham; Quinlan, Liam; Wong, Brad

    2016-04-05

    With the introduction of more fuel cell electric vehicles (FCEVs) on U.S. roadways, especially in California, the need for available hydrogen refueling stations is growing. While funding from the California Energy Commission is helping to solve this problem, solutions need to be developed and implemented to help reduce the time to commission a hydrogen station. The current practice of hydrogen station acceptance can take months because each vehicle manufacturer conducts their own testing and evaluation. This process is not practical or sufficient to support the timely development of a hydrogen fueling station network. To address this issue, as part of the Hydrogen Fueling Infrastructure Research and Station Technology (H2FIRST) Project Sandia National Laboratories and the National Renewable Energy Laboratory along with a team of stakeholders and contractor Powertech Labs has developed the Hydrogen Station Equipment Performance (HyStEP) Device. The HyStEP Device is intended to be a surrogate for FCEVs that can be used to collect data on hydrogen station fueling performance. The device includes three Type IV 70 MPa tanks capable of storing a total of 9 kg H2 that are instrumented with pressure and temperature sensors. The tanks can be used individually or in parallel to simulate small, medium, and large fuel systems. The tanks are connected to a 70 MPa receptacle equipped with pressure and temperature sensor as well as infrared communications integrated with a data acquisition, analysis, and control system. The HyStEP Device is capable of performing tests defined in the test method standard CSA HGV 4.3 and providing the data needed to ensure that hydrogen stations meet the fueling protocol standard SAE J2601-2014. These include IrDA communication tests, fault detection tests, and communication and non-communication fueling.

  6. Remember the water--a comment on EPS colligative properties.

    PubMed

    Keiding, K; Wybrandt, L; Nielsen, P H

    2001-01-01

    The relationship between water and activated sludge components was examined. Reevaluation of published data on freezing point depression, drying rates and dewatering has been performed. The basis of this has been the assumption that the water/sludge relationship is considered to be a colligative effect. Since the results indicate this to be the case, we suggest that the published concepts of "pools of water" are false. Data on swelling properties of EPS as a function of pH suggests that the colligative properties are largely determined by the counterions of charged polymers and surfaces.

  7. Sentinel-1 EPS Architecture And Power Conversion Trade-Off

    NASA Astrophysics Data System (ADS)

    Catalano, Toni Fabio; Costanitini, Stefano; Daparati, Giorgio

    2011-10-01

    The paper will present the selected EPS (Electrical Power System) Architecture for the Sentinel-1 mission. After a brief survey of Sentinel-1 mission, the EPS design will be illustrated, with particular focus on the architecture adopted for SAW (Solar Array Wing) power conversion and relevant trade-off. In the early phase of the project, various trade-offs have been carried out in order to define the suitable Sentinel- 1 EPS architecture. Mainly the following subjects have been exploited: -BTA (Battery) technology and topology identification; -SAW rotation strategy and relevant mechanism selection; -primary power bus voltage selection; - distribution and protection philosophy; -SAW power conditioning strategy. All those, and many minor ones, have been evaluated singly to assess the best solution for the individual problem and all together to evaluate the consequences of the interactions at subsystem level to be finally reflected in system budget and architecture sizing. As the choice of the most appropriate conditioning architecture is directly influenced by chosen EPS architecture and has direct impact on S/C (Spacecraft) capability to sustain required operational profile, specially considering the long mission lifetime plus mission extension, dedicated analysis and simulations have been carried out. This paper focuses on SAW conditioning trade-off analysis results along with a brief description of the in- house developed simulator used during this study. Basing on project inputs such as mission operational scenarios, system requirement and HW constraints, a direct comparison of the performances achievable with the different accounted conditioning systems, S3R, MPPT buck and MPPT boost, is given. Finally, the outcomes of simulations run lead to a substantial equivalence of the three architecture topologies if no specific BTA configuration is accounted (ideal configuration). When considering different BTA topologies (s-p or p-s) and related possible failures, a

  8. Morphology of Highly Textured E/EP Diblock Copolymers

    DTIC Science & Technology

    1994-05-26

    ORGANIZATION REPORT NUMBER(S) 12 1ONR 6a. NAME OF PERFORMING ORGANIZATION 6b. OFFICE SYMBOL 7a. NAME OF MONITORING ORGANIZATION MIT J (if applicable ) ONE 6C...e. NAME OF FUNDING /SPONSORING 8ab. OFFICE SYMBOL 9. PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER ORGANIZATION Of applicable ) ONR SC. ADDRESS (City...mepolYme. E/EP/5 of PolY~etbyke) (E) and poly(aibyhlino- isoepylane) (El’) use auloeria to big). lowe of plane strain conm- prolnasing ad1 s ogm ills

  9. PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

    PubMed Central

    Zablotska, Iryna; Grulich, Andrew E; Phanuphak, Nittaya; Anand, Tarandeep; Janyam, Surang; Poonkasetwattana, Midnight; Baggaley, Rachel; van Griensven, Frits; Lo, Ying-Ru

    2016-01-01

    Introduction HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM) and other key populations. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes. PMID:27760688

  10. Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype.

    PubMed

    Sando, T; Usui, T; Tanaka, I; Mori, K; Sasaki, Y; Fukuda, Y; Namba, T; Sugimoto, Y; Ichikawa, A; Narumiya, S

    1994-05-16

    A cDNA clone encoding the rat prostaglandin (PG) E receptor EP2 subtype was cloned from a rat lung cDNA library. It encodes 488 amino acid residues with putative seven-transmembrane domains. Specific binding of [3H]PGE2 was found in COS-7 cells transfected with the cDNA and was displaced with unlabeled prostaglandins in the order of PGE2 = PGE1 > iloprost > or = PGF2 alpha > or = PGD2. The binding was also inhibited by misoprostol, an EP2 and EP3 agonist, but not by sulprostone, an EP1 and EP3 agonist. Northern blot analysis demonstrated that the EP2 mRNA is widely expressed in various tissues, the significant expression being observed in the thymus, lung, spleen, heart stomach, and pancreas.

  11. R&D for the Post-EP Processes of Superconducting RF Cavity

    SciTech Connect

    Saeki, Takayuki; Funahashi, Y.; Hayano, H.; Kato, Seigo; Nishiwaki, Michiru; Sawabe, Motoaki; Ueno, Kenji; Watanabe, K.; Antoine, Claire; Berry, Stefurn; Eozenou, F.; Gasser, Y.; Visentin, B.; Clemens, William A.; Geng, Rongli; Manus, Robert; Tyagi, Puneet

    2009-11-01

    The Electro-Polishing (EP) process is the best candidate of final surface treatment for the production of ILC cavities. Nevertheless, the broad distribution of the gradient caused by field emitters in cavities is sitll a serious problem for the EP process. A candidate source of field emitter is the sulfur component which is produced in the EP process and remains the inner-surface of cavities. We studied the effect of Ethanole- and degreaser-rinse processes after the EP process by a unique method. Moreover, we tried to test the sponge cleaning as the post-EP process to remove the field emitter inside the cavcity. This article describe the results of series tests of the post-EP process at KEK.

  12. The Proton as Seen by the HERA Collider

    NASA Astrophysics Data System (ADS)

    Abt, Iris

    2016-10-01

    Deep-inelastic electron-proton (ep) scattering at the HERA collider has been very important in the investigation of the partonic structure of the proton. The neutral- and charged-current cross sections, measured over a large kinematic range, are one of the legacies of the first and so far only ep collider. Here I discuss the combination of H1 and ZEUS data. The HERA data alone can provide parton distribution functions (PDFs) within the framework of perturbative QCD. I also discuss the family of sets of PDFs called HERAPDF2.0 as well as the interpretation of such proton PDFs that characterize proton interactions in momentum space. I then introduce other possible applications of the precision cross sections. In addition, some measurements at HERA provide hints about spatial aspects of the proton. Finally, I present a brief discussion of the connection to nuclear physics.

  13. Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptor antagonists.

    PubMed

    Hategan, Georgeta; Polozov, Alexandre M; Zeller, Wayne; Cao, Hua; Mishra, Rama K; Kiselyov, Alex S; Ramirez, Jose; Halldorsdottir, Gudrún; Andrésson, Thornorkell; Gurney, Mark E; Singh, Jasbir

    2009-12-01

    We have developed a pharmacophore model for the EP(3) receptor antagonists based on its endogenous ligand PGE(2). This ligand-based design yielded a series of novel peri-substituted [4.3.0] bicyclic aromatics featuring 1-alklyaryl 7-heterocyclic sulfonamide substituents. The synthesized molecules are potent antagonists of human EP(3) receptor in vitro and show inhibition of rat platelets aggregation. Optimized derivatives display high selectivity over IP, FP, and other EP receptor panels.

  14. Epithelial Cell Adhesion Molecule (EpCAM) Regulates Claudin Dynamics and Tight Junctions* ♦

    PubMed Central

    Wu, Chuan-Jin; Mannan, Poonam; Lu, Michael; Udey, Mark C.

    2013-01-01

    Epithelial cell adhesion molecule (EpCAM) (CD326) is a surface glycoprotein expressed by invasive carcinomas and some epithelia. Herein, we report that EpCAM regulates the composition and function of tight junctions (TJ). EpCAM accumulated on the lateral interfaces of human colon carcinoma and normal intestinal epithelial cells but did not co-localize with TJ. Knockdown of EpCAM in T84 and Caco-2 cells using shRNAs led to changes in morphology and adhesiveness. TJ formed readily after EpCAM knockdown; the acquisition of trans-epithelial electroresistance was enhanced, and TJ showed increased resistance to disruption by calcium chelation. Preparative immunoprecipitation demonstrated that EpCAM bound tightly to claudin-7. Co-immunoprecipitation documented associations of EpCAM with claudin-7 and claudin-1 but not claudin-2 or claudin-4. Claudin-1 associated with claudin-7 in co-transfection experiments, and claudin-7 was required for association of claudin-1 with EpCAM. EpCAM knockdown resulted in decreases in claudin-7 and claudin-1 proteins that were reversed with lysosome inhibitors. Immunofluorescence microscopy revealed that claudin-7 and claudin-1 continually trafficked into lysosomes. Although EpCAM knockdown decreased claudin-1 and claudin-7 protein levels overall, accumulations of claudin-1 and claudin-7 in TJ increased. Physical interactions between EpCAM and claudins were required for claudin stabilization. These findings suggest that EpCAM modulates adhesion and TJ function by regulating intracellular localization and degradation of selected claudins. PMID:23486470

  15. Integral Benchmark Data for Nuclear Data Testing Through the ICSBEP & IRPhEP

    SciTech Connect

    J. Blair Briggs; John D. Bess; Jim Gulliford; Ian Hill

    2013-10-01

    The status of the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and International Reactor Physics Experiment Evaluation Project (IRPhEP) was last discussed directly with the nuclear data community at ND2007. Since ND2007, integral benchmark data that are available for nuclear data testing have increased significantly. The status of the ICSBEP and the IRPhEP is discussed and selected benchmark configurations that have been added to the ICSBEP and IRPhEP Handbooks since ND2007 are highlighted.

  16. General secretion pathway (eps) genes required for toxin secretion and outer membrane biogenesis in Vibrio cholerae.

    PubMed

    Sandkvist, M; Michel, L O; Hough, L P; Morales, V M; Bagdasarian, M; Koomey, M; DiRita, V J; Bagdasarian, M

    1997-11-01

    The general secretion pathway (GSP) of Vibrio cholerae is required for secretion of proteins including chitinase, enterotoxin, and protease through the outer membrane. In this study, we report the cloning and sequencing of a DNA fragment from V. cholerae, containing 12 open reading frames, epsC to -N, which are similar to GSP genes of Aeromonas, Erwinia, Klebsiella, Pseudomonas, and Xanthomonas spp. In addition to the two previously described genes, epsE and epsM (M. Sandkvist, V. Morales, and M. Bagdasarian, Gene 123: 81-86, 1993; L. J. Overbye, M. Sandkvist, and M. Bagdasarian, Gene 132:101-106, 1993), it is shown here that epsC, epsF, epsG, and epsL also encode proteins essential for GSP function. Mutations in the eps genes result in aberrant outer membrane protein profiles, which indicates that the GSP, or at least some of its components, is required not only for secretion of soluble proteins but also for proper outer membrane assembly. Several of the Eps proteins have been identified by use of the T7 polymerase-promoter system in Escherichia coli. One of them, a pilin-like protein, EpsG, was analyzed also in V. cholerae and found to migrate as two bands on polyacrylamide gels, suggesting that in this organism it might be processed or otherwise modified by a prepilin peptidase. We believe that TcpJ prepilin peptidase, which processes the subunit of the toxin-coregulated pilus, TcpA, is not involved in this event. This is supported by the observations that apparent processing of EpsG occurs in a tcpJ mutant of V. cholerae and that, when coexpressed in E. coli, TcpJ cannot process EpsG although the PilD peptidase from Neisseria gonorrhoeae can.

  17. Integral Benchmark Data for Nuclear Data Testing Through the ICSBEP & IRPhEP

    NASA Astrophysics Data System (ADS)

    Briggs, J. B.; Bess, J. D.; Gulliford, J.

    2014-04-01

    The status of the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and International Reactor Physics Experiment Evaluation Project (IRPhEP) was last discussed directly with the nuclear data community at ND2007. Since ND2007, integral benchmark data that are available for nuclear data testing have increased significantly. The status of the ICSBEP and the IRPhEP is discussed and selected benchmark configurations that have been added to the ICSBEP and IRPhEP Handbooks since ND2007 are highlighted.

  18. Prostanoid receptor EP2 as a therapeutic target.

    PubMed

    Ganesh, Thota

    2014-06-12

    Cycoloxygenase-2 (COX-2) induction is prevalent in a variety of (brain and peripheral) injury models where COX-2 levels correlate with disease progression. Thus, COX-2 has been widely explored for anti-inflammatory therapy with COX-2 inhibitors, which proved to be effective in reducing the pain and inflammation in patients with arthritis and menstrual cramps, but they have not provided any benefit to patients with chronic inflammatory neurodegenerative disease. Recently, two COX-2 drugs, rofecoxib and valdecoxib, were withdrawn from the United States market due to cardiovascular side effects. Thus, future anti-inflammatory therapy could be targeted through a specific prostanoid receptor downstream of COX-2. The PGE2 receptor EP2 is emerging as a pro-inflammatory target in a variety of CNS and peripheral diseases. Here we highlight the latest developments on the role of EP2 in diseases, mechanism of activation, and small molecule discovery targeted either to enhance or to block the function of this receptor.

  19. Prostanoid Receptor EP2 as a Therapeutic Target

    PubMed Central

    Ganesh, Thota

    2014-01-01

    Cycoloxygenase-2 (COX-2) induction is prevalent in a variety of (brain and peripheral) injury models where COX-2 levels correlate with disease progression. Thus, COX-2 has been widely explored for anti-inflammatory therapy with COX-2 inhibitors, which proved to be effective in reducing the pain and inflammation in patients with arthritis and menstrual cramps, but they have not provided any benefit to patients with chronic inflammatory neurodegenerative disease. Recently, two COX-2 drugs: rofecoxib and valdecoxib were withdrawn from the United States market due to cardiovascular side effects. Thus, future anti-inflammatory therapy could be targeted through a specific prostanoid receptor downstream of COX-2. The PGE2 receptor EP2 is emerging as a pro-inflammatory target in a variety of CNS and peripheral diseases. Here we highlight the latest developments on the role of EP2 in diseases, mechanism of activation and small molecule discovery targeted either to enhance or to block the function of this receptor. PMID:24279689

  20. On the affordances of the MaxEP principle

    NASA Astrophysics Data System (ADS)

    Chung, Bong Jae; McDermid, Kirk; Vaidya, Ashwin

    2014-01-01

    Optimality principles have long been popular in the natural sciences and enjoyed much successes in various applications. However these principles seem to be disparate, each applied in limited contexts and there are far too many of them causing some consternation among scientists and philosophers of science regarding the ad-hoc nature of the optimality arguments. In this paper, we discuss the Maximum entropy production (MaxEP) as a plausible over-arching principle to understand stable configurations in fluid mechanics and related problems. The MaxEP being based upon sound physical arguments and in the immutable laws of thermodynamics along with the fact that it has been successfully co-opted across disciplines makes it worthy of attention. We discuss various physical and metaphysical aspects of this principle and use it to analyze some model problems regarding patterns in particle sedimentation such as sedimentation of a particle in Newtonian and non-Newtonian fluids and stable deformation of a falling droplet.

  1. Shock-Wave Acceleration of Protons on OMEGA EP

    NASA Astrophysics Data System (ADS)

    Haberberger, D.; Froula, D. H.; Pak, A.; Link, A.; Patel, P.; Fiuza, F.; Tochitsky, S.; Joshi, C.

    2016-10-01

    The creation of an electrostatic shock wave and ensuing ion acceleration is studied on the OMEGA EP Laser System at the Laboratory for Laser Energetics. Previous work using a 10- μm CO2 laser in a H2 gas jet shows promising results for obtaining narrow spectral features in the accelerated proton spectra. Scaling the shock-wave acceleration mechanism to the 1- μm-wavelength drive laser makes it possible to use petawatt-scale laser systems such as OMEGA-EP, but involves tailoring of the plasma profile. To accomplish the necessitated sharp rise to near-critical plasma density and a long exponential fall, an 1- μm-thick CH foil is illuminated on the back side by thermal x rays produced from an irradiated gold foil. The plasma density is measured using the fourth-harmonic probe system, the accelerating fields are probed using an orthogonal proton source, and the accelerated protons and ions are detected with a Thomson parabola. These results will be presented and compared with particle-in-cell simulations. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944 and LLNL's Laboratory Directed Research and Development program under project 15-LW-095.

  2. Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice

    PubMed Central

    Hosono, Kanako; Isonaka, Risa; Kawakami, Tadashi; Narumiya, Shuh; Majima, Masataka

    2016-01-01

    Lymphangiogenesis plays an important role in homeostasis, metabolism, and immunity, and also occurs during wound-healing. Here, we examined the roles of prostaglandin E2 (PGE2) receptor (EP) signaling in enhancement of lymphangiogenesis in wound healing processes. The hole-punch was made in the ears of male C57BL/6 mice using a metal ear punch. Healing process and lymphangiogenesis together with macrophage recruitment were analyzed in EP knockout mice. Lymphangiogenesis was up-regulated in the granulation tissues at the margins of punched-hole wounds in mouse ears, and this increase was accompanied by increased expression levels of COX-2 and microsomal prostaglandin E synthase-1. Administration of celecoxib, a COX-2 inhibitor, suppressed lymphangiogenesis in the granulation tissues and reduced the induction of the pro-lymphangiogenic factors, vascular endothelial growth factor (VEGF) -C and VEGF-D. Topical applications of selective EP receptor agonists enhanced the expressions of lymphatic vessel endothelial hyaluronan receptor-1 and VEGF receptor-3. The wound-healing processes and recruitment of CD11b-positive macrophages, which produced VEGF-C and VEGF-D, were suppressed under COX-2 inhibition. Mice lacking either EP3 or EP4 exhibited reduced wound-healing, lymphangiogenesis and recruitment of M2 macrophages, compared with wild type mice. Proliferation of cultured human lymphatic endothelial cells was not detected under PGE2 stimulation. Lymphangiogenesis and recruitment of M2 macrophages that produced VEGF-C/D were suppressed in mice treated with a COX-2 inhibitor or lacking either EP3 or EP4 during wound healing. COX-2 and EP3/EP4 signaling may be novel targets to control lymphangiogenesis in vivo. PMID:27711210

  3. Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice.

    PubMed

    Hosono, Kanako; Isonaka, Risa; Kawakami, Tadashi; Narumiya, Shuh; Majima, Masataka

    2016-01-01

    Lymphangiogenesis plays an important role in homeostasis, metabolism, and immunity, and also occurs during wound-healing. Here, we examined the roles of prostaglandin E2 (PGE2) receptor (EP) signaling in enhancement of lymphangiogenesis in wound healing processes. The hole-punch was made in the ears of male C57BL/6 mice using a metal ear punch. Healing process and lymphangiogenesis together with macrophage recruitment were analyzed in EP knockout mice. Lymphangiogenesis was up-regulated in the granulation tissues at the margins of punched-hole wounds in mouse ears, and this increase was accompanied by increased expression levels of COX-2 and microsomal prostaglandin E synthase-1. Administration of celecoxib, a COX-2 inhibitor, suppressed lymphangiogenesis in the granulation tissues and reduced the induction of the pro-lymphangiogenic factors, vascular endothelial growth factor (VEGF) -C and VEGF-D. Topical applications of selective EP receptor agonists enhanced the expressions of lymphatic vessel endothelial hyaluronan receptor-1 and VEGF receptor-3. The wound-healing processes and recruitment of CD11b-positive macrophages, which produced VEGF-C and VEGF-D, were suppressed under COX-2 inhibition. Mice lacking either EP3 or EP4 exhibited reduced wound-healing, lymphangiogenesis and recruitment of M2 macrophages, compared with wild type mice. Proliferation of cultured human lymphatic endothelial cells was not detected under PGE2 stimulation. Lymphangiogenesis and recruitment of M2 macrophages that produced VEGF-C/D were suppressed in mice treated with a COX-2 inhibitor or lacking either EP3 or EP4 during wound healing. COX-2 and EP3/EP4 signaling may be novel targets to control lymphangiogenesis in vivo.

  4. PREFACE: The EPS High Energy Particle Physics Conference

    NASA Astrophysics Data System (ADS)

    Barlow, Roger

    2008-03-01

    HEPP2007, the EPS High Energy Particle Physics Conference, was held in Manchester from July 19-26 2007. It brought together 580 delegates across the whole subject: from string theorists to detector technologists, from young postgraduate students to senior professors. Geographically they came from the UK, from the rest of Europe, from North America, and from the rest of the world. It covered the whole spectrum of the subject, not only accelerator-based experiments but also its astrophysical and cosmological aspects. The parallel and plenary talks can be found in these proceedings. A key feature of the conference, as always, was the award of the prizes: this year the EPS prize was awarded to Makoto Kobayashi and Toshihide Maskawa for their explanation of CP violation with a 6 quark model—Kobayashi came to accept it in person. The Gribov medal went to Niklas Beisert, the outreach prize to Richard Jacobsson and Charles Timmermans and the Young Physicist prizer to I Furic, G Gomez-Ceballos and S Menzemer. Parallel sessions were held in Manchester University, and plenary talks were held in the Bridgewater Hall in Manchester Town centre, a magnificent modern venue whose positive and co-operative staff enabled the conference to make the most of the impressive surroundings. We were able to put the hall to its proper purpose one evening with a concert by the Fairey Band—one of the distinctive brass bands who form part of the rich musical tradition of the North of England, and came as something new and different to many of the delegates. The conference ran smoothly and successfully, thanks largely to hard work by the local organising committee who devoted a lot of time to planning, producing ideas, and anticipating potential problems. Many of them were not from Manchester itself but from other universities and laboratories in the North of England, so their dedication was especially appreciated. The EPS committee also played a major part, by the selection of plenary

  5. The Role of EPS in Microhydrology and Transport Processes Affecting Microbial Activity in Unsaturated Porous Media

    NASA Astrophysics Data System (ADS)

    Or, D.; Phutane, S.

    2005-12-01

    Extra-cellular Polymeric Substances (EPS) refers to biopolymers excreted and surrounding soil bacterial cells (and other biota) forming the scaffolding for colonies and serving a wide array of transport, nutrient entrapment, and mechanical functions. In essence, EPS is a porous matrix through which aqueous, gaseous and nutrient fluxes flow to supply the embedded bacterial cells. The large water holding capacity and retarded water loss rates of EPS dampens rapid fluctuations in hydration status of host porous medium which sustain higher diffusion fluxes than in surrounding porous medium, and shelters microbial cells from effect of rapid desiccation or rewetting. The morphology of EPS changes from an open well-hydrated bioweb to dense and highly cross-linked structure under dry conditions. Such morphological changes are accompanied by enhanced mechanical strength and retardation of water loss that provide additional time for physiological adaptation to desiccation. Additional capacitance results from the disparity in dynamic hydrological properties between EPS and soil that promotes water entrapment in EPS during rapid drainage. EPS may also trap dissolved nutrients that may be unevenly distributed and irregularly supplied in unsaturated environments, thereby increasing nutrient availability in the microhabitat and offsetting decreased supply by diffusion during drying. The remarkable transport and mechanical properties of EPS makes it an important stabilizing agent for soil aggregation and even minute amounts of EPS may significantly alter macroscopic hydrological properties of host porous medium.

  6. Interactions of EPS with soil minerals: A combination study by ITC and CLSM.

    PubMed

    Lin, Di; Ma, Wenting; Jin, Zhaoxia; Wang, Yixuan; Huang, Qiaoyun; Cai, Peng

    2016-02-01

    The adsorption of extracellular polymeric substances (EPS) from Pseudomonas putida on montmorillonite, kaolinite and goethite was investigated as a function of pH using batch studies coupled with confocal laser scanning microscopy (CLSM) and isothermal titration calorimetry (ITC). Characterization by Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectroscopy showed that the extracted EPS contained carboxyl, phosphoryl, amino, and hydroxyl on functional groups as well as polysaccharides, protein and nucleic acid on components. The mass fraction of EPS adsorption on minerals decreased with the final pH increased from 3.0 to 9.0. The mass fraction of EPS-N adsorption varied with pH values and was higher than that of EPS-C or EPS-P on montmorillonite and kaolinite, while the mass fraction of EPS-P adsorption was the highest on goethite. CLSM results further demonstrated that proteins were predominantly distributed on the montmorillonite and kaolinite surfaces, while nucleic acids were mainly on the goethite surface. ITC results revealed that the adsorption process in all mineral systems was exothermic, and pH altered the heat effect of EPS-mineral reactions. The data obtained in this study would facilitate a better understanding of the adsorption mechanisms of EPS on minerals.

  7. Sequestration of nanoparticles by an EPS matrix reduces the particle-specific bactericidal activity

    NASA Astrophysics Data System (ADS)

    Wang, Qian; Kang, Fuxing; Gao, Yanzheng; Mao, Xuewei; Hu, Xiaojie

    2016-02-01

    Most artificial nanomaterials are known to exhibit broad-spectrum bactericidal activity; however, the defence mechanisms that bacteria use based on extracellular polymeric substances (EPS) to detoxify nanoparticles (NPs) are not well known. We ruled out the possibility of ion-specific bactericidal activity by showing the lack of equivalent dissolved zinc and silicon toxicity and determined the particle-specific toxicity of ZnO and SiO2 nanoparticles (ZnONPs/SiO2NPs) through dialysis isolation experiments. Surprisingly, the manipulation of the E. coli EPS (i.e., no EPS manipulation or EPS removal by sonication/centrifugation) showed that their particle-specific bactericidal activity could be antagonized by NP-EPS sequestration. The survival rates of pristine E. coli (no EPS manipulation) reached 65% (ZnONPs, 500 mg L‑1) and 79% (SiO2NPs, 500 mg L‑1), whereas survival rates following EPS removal by sonication/centrifugation were 11% and 63%, respectively. Transmission electron microscopy (TEM) combined with fluorescence micro-titration analysis and Fourier-transform infrared spectroscopy (FTIR) showed that protein-like substances (N-H and C-N in amide II) and secondary carbonyl groups (C=O) in the carboxylic acids of EPS acted as important binding sites that were involved in NP sequestration. Accordingly, the amount and composition of EPS produced by bacteria have important implications for the bactericidal efficacy and potential environmental effects of NPs.

  8. EpCAM associates with endoplasmic reticulum aminopeptidase 2 (ERAP2) in breast cancer cells.

    PubMed

    Gadalla, Salah-Eldin; Öjemalm, Karin; Vasquez, Patricia Lara; Nilsson, Ingmarie; Ericsson, Christer; Zhao, Jian; Nistér, Monica

    2013-09-20

    Epithelial cell adhesion molecule (EpCAM) is an epithelial and cancer cell "marker" and there is a cumulative and growing evidence of its signaling role. Its importance has been recognized as part of the breast cancer stem cell phenotype, the tumorigenic breast cancer stem cell is EpCAM(+). In spite of its complex functions in normal cell development and cancer, relatively little is known about EpCAM-interacting proteins. We used breast cancer cell lines and performed EpCAM co-immunoprecipitation followed by mass spectrometry in search for novel potentially interacting proteins. The endoplasmic reticulum aminopeptidase 2 (ERAP2) was found to co-precipitate with EpCAM and to co-localize in the cytoplasm/ER and the plasma membrane. ERAP2 is a proteolytic enzyme set in the endoplasmic reticulum (ER) where it plays a central role in the trimming of peptides for presentation by MHC class I molecules. Expression of EpCAM and ERAP2 in vitro in the presence of dog pancreas rough microsomes (ER vesicles) confirmed N-linked glycosylation, processing in ER and the size of EpCAM. The association between ERAP2 and EpCAM is a unique and novel finding that provides new ideas on EpCAM processing and on how antigen presentation may be regulated in cancer.

  9. Sequestration of nanoparticles by an EPS matrix reduces the particle-specific bactericidal activity

    PubMed Central

    Wang, Qian; Kang, Fuxing; Gao, Yanzheng; Mao, Xuewei; Hu, Xiaojie

    2016-01-01

    Most artificial nanomaterials are known to exhibit broad-spectrum bactericidal activity; however, the defence mechanisms that bacteria use based on extracellular polymeric substances (EPS) to detoxify nanoparticles (NPs) are not well known. We ruled out the possibility of ion-specific bactericidal activity by showing the lack of equivalent dissolved zinc and silicon toxicity and determined the particle-specific toxicity of ZnO and SiO2 nanoparticles (ZnONPs/SiO2NPs) through dialysis isolation experiments. Surprisingly, the manipulation of the E. coli EPS (i.e., no EPS manipulation or EPS removal by sonication/centrifugation) showed that their particle-specific bactericidal activity could be antagonized by NP-EPS sequestration. The survival rates of pristine E. coli (no EPS manipulation) reached 65% (ZnONPs, 500 mg L−1) and 79% (SiO2NPs, 500 mg L−1), whereas survival rates following EPS removal by sonication/centrifugation were 11% and 63%, respectively. Transmission electron microscopy (TEM) combined with fluorescence micro-titration analysis and Fourier-transform infrared spectroscopy (FTIR) showed that protein-like substances (N-H and C-N in amide II) and secondary carbonyl groups (C=O) in the carboxylic acids of EPS acted as important binding sites that were involved in NP sequestration. Accordingly, the amount and composition of EPS produced by bacteria have important implications for the bactericidal efficacy and potential environmental effects of NPs. PMID:26856606

  10. More and more indirect signals for extra dimensions at more and more colliders

    SciTech Connect

    Rizzo, T.G.

    1999-06-01

    It has been recently suggested by Arkani-Hamed, Dimopoulos and Dvali that gravity may become strong at energies not far above the electroweak scale and thus remove the hierarchy problem. Such a scenario can be tested at both present and future accelerators since towers of Kaluza-Klein gravitons and associated scalar fields now play an important phenomenological role. In this paper we examine several processes for their sensitivity to a low scale for quantum gravity including deep inelastic ep scattering at DESY HERA, high precision low energy {nu}N scattering, Bhabha and Mo/ller scattering at linear colliders and both fermion and gluon pair production at {gamma}{gamma} colliders. {copyright} {ital 1999} {ital The American Physical Society}

  11. Measurement of the scintillation light quenching at room temperature of sodium recoils in NaI(Tl) and hydrogen recoils in NE 213 by the scattering of neutrons

    NASA Astrophysics Data System (ADS)

    Jagemann, Th.; Feilitzsch, F. v.; Jochum, J.

    2006-08-01

    At the newly installed neutron scattering facility for the calibration of Dark Matter (DM) detectors we have measured quenching factors (QFs) at room temperature in NE 213 and NaI(Tl). For proton energies Ep between 1 and 3.5 MeV we found the electron-equivalent energy Eee to obey the relation Eee=(0.23±0.03)Ep+(0.02±0.01)Ep2. The QF of the light output from Na recoils in NaI(Tl) at 850 keV was measured to be Q=0.21±0.04.

  12. Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs.

    PubMed

    Iskander, Deena; Psaila, Bethan; Gerrard, Gareth; Chaidos, Aristeidis; En Foong, Hui; Harrington, Yvonne; Karnik, Leena C; Roberts, Irene; de la Fuente, Josu; Karadimitris, Anastasios

    2015-04-16

    Diamond-Blackfan anemia (DBA) is a disorder characterized by a selective defect in erythropoiesis. Delineation of the precise defect is hampered by a lack of markers that define cells giving rise to erythroid burst- and erythroid colony-forming unit (BFU-E and CFU-E) colonies, the clonogenic assays that quantify early and late erythroid progenitor (EEP and LEP) potential, respectively. By combining flow cytometry, cell-sorting, and single-cell clonogenic assays, we identified Lin(-)CD34(+)CD38(+)CD45RA(-)CD123(-)CD71(+)CD41a(-)CD105(-)CD36(-) bone marrow cells as EEP giving rise to BFU-E, and Lin(-)CD34(+/-)CD38(+)CD45RA(-)CD123(-)CD71(+)CD41a(-)CD105(+)CD36(+) cells as LEP giving rise to CFU-E, in a hierarchical fashion. We then applied these definitions to DBA and identified that, compared with controls, frequency, and clonogenicity of DBA, EEP and LEP are significantly decreased in transfusion-dependent but restored in corticosteroid-responsive patients. Thus, both quantitative and qualitative defects in erythroid progenitor (EP) contribute to defective erythropoiesis in DBA. Prospective isolation of defined EPs will facilitate more incisive study of normal and aberrant erythropoiesis.

  13. Rayleigh scattering. [molecular scattering terminology redefined

    NASA Technical Reports Server (NTRS)

    Young, A. T.

    1981-01-01

    The physical phenomena of molecular scattering are examined with the objective of redefining the confusing terminology currently used. The following definitions are proposed: molecular scattering consists of Rayleigh and vibrational Raman scattering; the Rayleigh scattering consists of rotational Raman lines and the central Cabannes line; the Cabannes line is composed of the Brillouin doublet and the central Gross or Landau-Placzek line. The term 'Rayleigh line' should never be used.

  14. Prognostic role of PGE2 receptor EP2 in esophageal squamous cell carcinoma.

    PubMed

    Kuo, Kuang-Tai; Wang, Hao-Wei; Chou, Teh-Ying; Hsu, Wen-Hu; Hsu, Han-Shui; Lin, Chi-Hung; Wang, Liang-Shun

    2009-02-01

    Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, has been shown to affect numerous tumorigenic processes. PGE2 acts through G-protein-coupled receptors designated as EPs. Recently it has been documented that PGE2 promotes colon cancer cell growth via EP2. However, the expression and the prognostic role of EP2 in esophageal squamous cell carcinoma (ESCC) remained unknown. From January 1995 to January 2001, tissue samples from 226 patients with ESCC who underwent esophagectomies at our institutions were collected and made into tissue core arrays for study. EP2 expression was examined by immunohistochemical staining and confirmed by Western blot. The clinicopathologic data were then analyzed. EP2 overexpression was observed in 43.4% (98/226) of ESCC. Overexpression of EP2 correlated positively with depth of tumor invasion (T status) (P = 0.016) and was associated with worse overall survival (P = 0.047). In patients without regional or distant lymph node metastasis (N0 or M0), EP2 overexpression was associated with worse overall survival (P = 0.033 and P = 0.003, respectively). Using Cox regression analysis, T status, N status, and M status were the independent factors of overall survival, but EP2 expression was not. However, when focusing on patients with T1-3N0M0 status, EP2 expression became an independent factor of overall survival (P = 0.048). Our results show that EP2 overexpression was associated with worse prognosis, and correlated positively with T status in ESCC. Meanwhile, among those patients at earlier stages, EP2 overexpression significantly disclosed patients at high risks for poor prognosis.

  15. Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress

    PubMed Central

    Carrasco, Emilce; Werner, Peter; Casper, Diana

    2008-01-01

    Dopaminergic neurons in the substantia nigra (SN) selectively die in Parkinson’s disease (PD), but it is unclear how and why this occurs. Recent findings implicate prostaglandin E2 (PGE2) and two of its four receptors, namely EP1 and EP2, as mediators of degenerative and protective events in situations of acute and chronic neuronal death. EP1 activation can exacerbate excitotoxic damage in stroke models and our recent study showed that EP1 activation may explain the selective sensitivity of dopaminergic neurons to oxidative stress. Conversely, EP2 activation may be neuroprotective, although toxic effects have also been demonstrated. Here we investigated if and how EP2 activation might alter the survival of dopaminergic neurons following selective low-level oxidative injury evoked by the neurotoxin 6-hydroxydopamine (6-OHDA) in primary neuronal cultures prepared from embryonic rat midbrain. We found that cultured dopaminergic neurons displayed EP2 receptors. Butaprost, a selective EP2 agonist, significantly reduced 6-OHDA neurotoxicity. EP2 receptors are coupled to stimulatory G-proteins (Gs), which activate adenylate cyclase, increasing cAMP synthesis, which then activates protein kinase A (PKA). Both dibutyryl cAMP and forskolin reduced dopaminergic cell loss after 6-OHDA exposure. Conversely, KT5720 and H-89, two structurally distinct high-affinity PKA inhibitors, abolished the protective effect of butaprost, implicating cAMP-dependent PKA activity in the neuroprotection by EP2 activation. Finally, we show that melanized dopaminergic neurons in the human SN express EP2. This pathway warrants consideration as a neuroprotective strategy for PD. PMID:18597941

  16. Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress.

    PubMed

    Carrasco, Emilce; Werner, Peter; Casper, Diana

    2008-08-15

    Dopaminergic neurons in the substantia nigra (SN) selectively die in Parkinson's disease (PD), but it is unclear how and why this occurs. Recent findings implicate prostaglandin E(2) (PGE(2)) and two of its four receptors, namely EP1 and EP2, as mediators of degenerative and protective events in situations of acute and chronic neuronal death. EP1 activation can exacerbate excitotoxic damage in stroke models and our recent study showed that EP1 activation may explain the selective sensitivity of dopaminergic neurons to oxidative stress. Conversely, EP2 activation may be neuroprotective, although toxic effects have also been demonstrated. Here we investigated if and how EP2 activation might alter the survival of dopaminergic neurons following selective low-level oxidative injury evoked by the neurotoxin 6-hydroxydopamine (6-OHDA) in primary neuronal cultures prepared from embryonic rat midbrain. We found that cultured dopaminergic neurons displayed EP2 receptors. Butaprost, a selective EP2 agonist, significantly reduced 6-OHDA neurotoxicity. EP2 receptors are coupled to stimulatory G-proteins (Gs), which activate adenylate cyclase, increasing cAMP synthesis, which then activates protein kinase A (PKA). Both dibutyryl cAMP and forskolin reduced dopaminergic cell loss after 6-OHDA exposure. Conversely, KT5720 and H-89, two structurally distinct high-affinity PKA inhibitors, abolished the protective effect of butaprost, implicating cAMP-dependent PKA activity in the neuroprotection by EP2 activation. Finally, we show that melanized dopaminergic neurons in the human SN express EP2. This pathway warrants consideration as a neuroprotective strategy for PD.

  17. Deposition kinetics of extracellular polymeric substances (EPS) on silica in monovalent and divalent salts.

    PubMed

    Zhu, Pingting; Long, Guoyu; Ni, Jinren; Tong, Meiping

    2009-08-01

    The deposition kinetics of extracellular polymeric substances (EPS) on silica surfaces were examined in both monovalent and divalent solutions under a variety of environmentally relevant ionic strength and pH conditions by employing a quartz crystal microbalance with dissipation (DCM-D). Soluble EPS (SEPS) and bound EPS (BEPS) were extracted from four bacterial strains with different characteristics. Maximum favorable deposition rates (k(fa)) were observed for all EPS at low ionic strengths in both NaCl and CaCl2 solutions. With the increase of ionic strength, k(fa) decreased due to the simultaneous occurrence of EPS aggregation in solutions. Deposition efficiency (alpha; the ratio of deposition rates obtained under unfavorable versus corresponding favorable conditions) for all EPS increased with increasing ionic strength in both NaCl and CaCl2 solutions, which agreed with the trends of zeta potentials and was consistent with the classic Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. Comparison of alpha for SEPS and BEPS extracted from the same strain showed that the trends of alpha did not totally agree with trends of zeta potentials, indicating the deposition kinetics of EPS on silica surfaces were not only controlled by DLVO interactions, but also non-DLVO forces. Close comparison of alpha for EPS extracted from different sources showed alpha increased with increasing proteins to polysaccharides ratio. Subsequent experiments for EPS extracted from the same strain but with different proteins to polysaccharides ratios and from activated sludge also showed that alpha were largest for EPS with greatest proteins to polysaccharides ratio. Additional experiments for pure protein and solutions with different pure proteins to pure saccharides ratios further corroborated that larger proteins to polysaccharides ratio resulted in greater EPS deposition.

  18. Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition.

    PubMed

    Liu, Chao; Zhu, Ping; Wang, Wangsheng; Li, Wenjiao; Shu, Qun; Chen, Zi-Jiang; Myatt, Leslie; Sun, Kang

    2016-03-15

    The underlying mechanism leading to rupture of the membranes at parturition is not fully understood. Lysyl oxidase (LOX) cross-links collagen fibrils thereby increasing the tensile strength of the membranes. Thus, understanding the regulation of LOX expression may be of crucial importance for elucidation of the process of rupture of the fetal membranes. Prostaglandin E2 (PGE2), mainly produced in the amnion, plays crucial roles during human parturition. However it is not known whether PGE2 regulates LOX expression in the fetal membranes. Using primary human amnion fibroblasts, we showed that addition of PGE2 decreased LOX mRNA and protein levels, which were blocked by inhibition of EP2/EP4 receptors and the receptor-coupled cAMP/PKA pathway. EP2/EP4 receptor agonists and stimulators of the cAMP/PKA pathway consistently decreased LOX expression. Furthermore, PGE2 induced cyclo-oxygenase-2 (COX-2) expression, a key enzyme in PGE2 production, via an EP2 and EP4 receptor-coupled cAMP/PKA pathway. Small interfering RNA-mediated knock-down of COX-2 expression significantly increased the basal expression of LOX. In addition, an increase in COX-2 and a reciprocal decrease in LOX abundance occurred in amnion tissue following labor at term. In conclusion, we have revealed a feed-forward loop of induction of COX-2 and reduction in LOX expression by PGE2 acting via an EP2/EP4 receptor-coupled cAMP/PKA pathway in human amnion fibroblasts toward the end of gestation, which may play a significant role in the rupture of fetal membranes.

  19. EPS-I Polysaccharide Protects Mycoplasma pulmonis from Phagocytosis

    PubMed Central

    Shaw, Brandon M.; Daubenspeck, James M.; Simmons, Warren L.; Dybvig, Kevin

    2012-01-01

    Few mycoplasmal polysaccharides have been described and little is known about their role in pathogenesis. The infection of mice with Mycoplasma pulmonis has been utilized in many in vivo and in vitro studies to gain a better understanding of host-pathogen interactions during chronic respiratory infection. Although alveolar macrophages have a primary role in host defense, M. pulmonis is killed inefficiently in vitro. One antiphagocytic factor produced by the mycoplasma is the family of phase- and size-variable Vsa lipoproteins. However, bacteria generally employ multiple strategies for combating host defenses, with capsular polysaccharide often having a key role. We show here that mutants lacking the EPS-I polysaccharide of M. pulmonis exhibit increased susceptibility to binding and subsequent killing by alveolar macrophages. These results give further insight into how mycoplasmas are able to avoid the host immune system and sustain a chronic infection. PMID:23190331

  20. The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis.

    PubMed

    Katsuyama, M; Nishigaki, N; Sugimoto, Y; Morimoto, K; Negishi, M; Narumiya, S; Ichikawa, A

    1995-09-25

    A functional cDNA clone for the mouse prostaglandin (PG) E receptor EP2 subtype was isolated from a mouse cDNA library. The mouse EP2 receptor consists of 362 amino acid residues with seven putative transmembrane domains. [3H]PGE2 bound specifically to the membrane of Chinese hamster ovary cells stably expressing the cloned receptor. This binding was displaced by unlabeled prostanoids in the order of PGE2 = PGE1 > iloprost, a stable PGI2 agonist > PGF2 alpha > PGD2. Binding was also inhibited by butaprost (an EP2 agonist) and to a lesser extent by M&B 28767 (an EP3 agonist), but not by sulprostone (an EP1 and EP3 agonist) or SC-19220 (an EP1 antagonist). PGE2 and butaprost increased the cAMP level in the Chinese hamster ovary cells in a concentration-dependent manner. Northern blot analysis revealed that EP2 mRNA is expressed most abundantly in the uterus, followed by the spleen, lung, thymus, ileum, liver, and stomach.

  1. EP2 receptors mediate airway relaxation to substance P, ATP, and PGE2.

    PubMed

    Fortner, C N; Breyer, R M; Paul, R J

    2001-08-01

    Substance P (SP) and ATP evoke transient, epithelium-dependent relaxation of constricted mouse tracheal smooth muscle. Relaxation to either SP or ATP is blocked by indomethacin, but the specific eicosanoid(s) involved have not been definitively identified. SP and ATP are reported to release PGE2 from airway epithelium in other species, suggesting PGE2 as a likely mediator in epithelium-dependent airway relaxation. Using mice homozygous for a gene-targeted deletion of the EP2 receptor [EP2(-/-)], one of the PGE2 receptors, we tested the hypothesis that PGE2 is the primary mediator of relaxation to SP or ATP. Relaxation in response to SP or ATP was significantly reduced in tracheas from EP2(-/-) mice. There were no differences between EP2(-/-) and wild-type tracheas in their physical dimensions, contraction to ACh, or relaxation to isoproterenol, thus ruling out any general alterations of smooth muscle function. There were also no differences between EP2(-/-) and wild-type tracheas in basal or stimulated PGE2 production. Exogenous PGE2 produced significantly less relaxation in EP2(-/-) tracheas compared with the wild type. Taken together, this experimental evidence supports the following two conclusions: EP2 receptors are of primary importance in airway relaxation to PGE2 and relaxation to SP or ATP is mediated through PGE2 acting on EP2 receptors.

  2. 42 CFR 495.10 - Participation requirements for EPs, eligible hospitals, and CAHs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM General Provisions § 495.10 Participation requirements for EPs... 42 Public Health 5 2010-10-01 2010-10-01 false Participation requirements for EPs,...

  3. 30 CFR 550.215 - What hydrogen sulfide (H2S) information must accompany the EP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What hydrogen sulfide (H2S) information must accompany the EP? 550.215 Section 550.215 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... Information Contents of Exploration Plans (ep) § 550.215 What hydrogen sulfide (H2S) information...

  4. 30 CFR 250.215 - What hydrogen sulfide (H2S) information must accompany the EP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What hydrogen sulfide (H2S) information must accompany the EP? 250.215 Section 250.215 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Contents of Exploration Plans (ep) § 250.215 What hydrogen sulfide (H2S) information must accompany the...

  5. 30 CFR 550.215 - What hydrogen sulfide (H2S) information must accompany the EP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What hydrogen sulfide (H2S) information must accompany the EP? 550.215 Section 550.215 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... Information Contents of Exploration Plans (ep) § 550.215 What hydrogen sulfide (H2S) information...

  6. 30 CFR 250.215 - What hydrogen sulfide (H2S) information must accompany the EP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What hydrogen sulfide (H2S) information must accompany the EP? 250.215 Section 250.215 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION... CONTINENTAL SHELF Plans and Information Contents of Exploration Plans (ep) § 250.215 What hydrogen...

  7. 30 CFR 550.215 - What hydrogen sulfide (H2S) information must accompany the EP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What hydrogen sulfide (H2S) information must accompany the EP? 550.215 Section 550.215 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... Information Contents of Exploration Plans (ep) § 550.215 What hydrogen sulfide (H2S) information...

  8. 30 CFR 550.226 - What Coastal Zone Management Act (CZMA) information must accompany the EP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the EP? 550.226 Section 550.226 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... and Information Contents of Exploration Plans (ep) § 550.226 What Coastal Zone Management Act...

  9. 30 CFR 250.226 - What Coastal Zone Management Act (CZMA) information must accompany the EP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the EP? 250.226 Section 250.226 Mineral Resources MINERALS MANAGEMENT SERVICE... and Information Contents of Exploration Plans (ep) § 250.226 What Coastal Zone Management Act...

  10. 30 CFR 250.226 - What Coastal Zone Management Act (CZMA) information must accompany the EP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the EP? 250.226 Section 250.226 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... Zone Management Act (CZMA) information must accompany the EP? The following CZMA information...

  11. 30 CFR 550.226 - What Coastal Zone Management Act (CZMA) information must accompany the EP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the EP? 550.226 Section 550.226 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... and Information Contents of Exploration Plans (ep) § 550.226 What Coastal Zone Management Act...

  12. 30 CFR 550.226 - What Coastal Zone Management Act (CZMA) information must accompany the EP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the EP? 550.226 Section 550.226 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... and Information Contents of Exploration Plans (ep) § 550.226 What Coastal Zone Management Act...

  13. Composition of Extracellular Polymeric Substances (EPS) produced by Flavobacterium columnare isolated from tropical fish in Brazil

    PubMed Central

    de Alexandre Sebastião, Fernanda; Pilarski, Fabiana; Lemos, Manoel Victor Franco

    2013-01-01

    Thirty nine isolates of Flavobacterium columnare from Brazilian fish farms had their carbohydrate composition of EPS evaluated by high efficiency liquid chromatography, using the phenol-sulfuric acid method of EPS. The occurrence of capsules on F. columnare cells was not directly related to biofilm formation, and the predominant monosaccharide is glucose. PMID:24516426

  14. 76 FR 52952 - Student Services Contract EP-11-D-000403 Yin Gu; Transfer of Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... AGENCY Student Services Contract EP-11-D-000403 Yin Gu; Transfer of Data AGENCY: Environmental Protection... Rodenticide Act (FIFRA) and the Federal Food, Drug, and Cosmetic Act (FFDCA), including information that may... Student Services Contract EP- 11-D-000403 Yin Gu in accordance with 40 CFR 2.307(h)(3) and...

  15. Differential expression of prostaglandin E receptor subtype EP2 in rat uterus during early pregnancy.

    PubMed

    Shi, J J; Ma, X H; Diao, H L; Ni, H; Xu, L B; Zhu, H; Yang, Z M

    2005-10-01

    PGE2 is essential for mammalian female reproduction. This study was to examine the expression of EP2 gene in the rat uterus during early pregnancy, delayed implantation and artificial decidualization by in situ hybridization and immunohistochemistry. There was no detectable EP2 mRNA expression in the uterus from days 1 to 4 of pregnancy (day 1 = day of vaginal sperm). A low level of EP2 immunostaining was observed in the luminal and glandular epithelium from days 1 to 4 of pregnancy. Both EP2 mRNA and protein expression were highly detected in the luminal epithelium at implantation sites on day 6 of pregnancy. EP2 expression decreased from day 7 of pregnancy and was undetectable on days 8 and 9 of pregnancy. After delayed implantation was terminated by estrogen treatment and the embryo implanted, both EP2 mRNA and protein expression were strongly observed in the luminal epithelium at the implantation site. There was no detectable EP2 expression in both control and decidualized uteri. In conclusion, these data suggest that EP2 expression at implantation site may play an important role during embryo implantation in rats.

  16. Molecular Basis for the Dual Function of Eps8 on Actin Dynamics: Bundling and Capping

    PubMed Central

    Hazelwood, Larnele; Disanza, Andrea; Liu, HongJun; Perlade, Emilie; Malabarba, Maria Grazia; Pasqualato, Sebastiano; Maiolica, Alessio; Confalonieri, Stefano; Le Clainche, Christophe; Offenhauser, Nina; Block, Jennifer; Rottner, Klemens; Di Fiore, Pier Paolo; Carlier, Marie-France; Volkmann, Niels; Hanein, Dorit; Scita, Giorgio

    2010-01-01

    Actin capping and cross-linking proteins regulate the dynamics and architectures of different cellular protrusions. Eps8 is the founding member of a unique family of capping proteins capable of side-binding and bundling actin filaments. However, the structural basis through which Eps8 exerts these functions remains elusive. Here, we combined biochemical, molecular, and genetic approaches with electron microscopy and image analysis to dissect the molecular mechanism responsible for the distinct activities of Eps8. We propose that bundling activity of Eps8 is mainly mediated by a compact four helix bundle, which is contacting three actin subunits along the filament. The capping activity is mainly mediated by a amphipathic helix that binds within the hydrophobic pocket at the barbed ends of actin blocking further addition of actin monomers. Single-point mutagenesis validated these modes of binding, permitting us to dissect Eps8 capping from bundling activity in vitro. We further showed that the capping and bundling activities of Eps8 can be fully dissected in vivo, demonstrating the physiological relevance of the identified Eps8 structural/functional modules. Eps8 controls actin-based motility through its capping activity, while, as a bundler, is essential for proper intestinal morphogenesis of developing Caenorhabditis elegans. PMID:20532239

  17. The Folly of Making EPS Comparisons across Companies: Do Accounting Textbooks Send the Correct Message?

    ERIC Educational Resources Information Center

    Kelley, Timothy P.; Hora, Judith A.

    2008-01-01

    This paper demonstrates why EPS comparisons across companies are meaningless. An example is provided showing how a company with a higher ROE than another company may have a lower EPS simply from having a lower book value per share (and more shares outstanding) than the comparison company. While ROE comparisons across companies can be useful,…

  18. 30 CFR 550.222 - What lease stipulations information must accompany the EP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What lease stipulations information must accompany the EP? 550.222 Section 550.222 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... Information Contents of Exploration Plans (ep) § 550.222 What lease stipulations information must...

  19. 30 CFR 550.222 - What lease stipulations information must accompany the EP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What lease stipulations information must accompany the EP? 550.222 Section 550.222 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... Information Contents of Exploration Plans (ep) § 550.222 What lease stipulations information must...

  20. EpCAM Intracellular Domain Promotes Porcine Cell Reprogramming by Upregulation of Pluripotent Gene Expression via Beta-catenin Signaling

    PubMed Central

    Yu, Tong; Ma, Yangyang; Wang, Huayan

    2017-01-01

    Previous study showed that expression of epithelial cell adhesion molecule (EpCAM) was significantly upregulated in porcine induced pluripotent stem cells (piPSCs). However, the regulatory mechanism and the downstream target genes of EpCAM were not well investigated. In this study, we found that EpCAM was undetectable in fibroblasts, but highly expressed in piPSCs. Promoter of EpCAM was upregulated by zygotic activated factors LIN28, and ESRRB, but repressed by maternal factors OCT4 and SOX2. Knocking down EpCAM by shRNA significantly reduced the pluripotent gene expression. Conversely, overexpression of EpCAM significantly increased the number of alkaline phosphatase positive colonies and elevated the expression of endogenous pluripotent genes. As a key surface-to-nucleus factor, EpCAM releases its intercellular domain (EpICD) by a two-step proteolytic processing sequentially. Blocking the proteolytic processing by inhibitors TAPI-1 and DAPT could reduce the intracellular level of EpICD and lower expressions of OCT4, SOX2, LIN28, and ESRRB. We noticed that increasing intracellular EpICD only was unable to improve activity of EpCAM targeted genes, but by blocking GSK-3 signaling and stabilizing beta-catenin signaling, EpICD could then significantly stimulate the promoter activity. These results showed that EpCAM intracellular domain required beta-catenin signaling to enhance porcine cell reprogramming. PMID:28393933

  1. Expression of EpCam and Villin in Barrett’s Esophagus and in Gastric Cardia

    PubMed Central

    Anders, Mario; Sarbia, Mario; Grotzinger, Carsten; Meining, Alexander; Hofler, Heinz; Wiedenmann, Bertram; Rosch, Thomas

    2008-01-01

    In the current study we aimed to clarify the potential of EpCAM and villin as in vivo biomarkers for both Barrett esophagus (BE)-associated neoplasia and BE versus cardiac mucosa. Immunohistochemical staining in BE with various degrees of intraepithelial neoplasia (IN), Barrett carcinoma (BC) and in normal cardiac mucosa (CM) revealed a lack of EpCam and villin in squamous esophageal epithelium. All specimens of IN and BC showed EpCam with varying staining intensities. In 57% of CM samples a weak signal was detected; the remainder displayed strong EpCam expression. Villin was found in 97% of BE specimens and in all those with IN; 37% of BC and 75% of CM specimens were also positive. We conclude that expression of EpCam and villin differs only between squamous epithelium and BE. Determination of these proteins does not allow discrimination between different degrees of neoplasia or between esophageal intestinal metaplasia and cardiac mucosa. PMID:18688077

  2. EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis.

    PubMed

    Greaves, Erin; Horne, Andrew W; Jerina, Helen; Mikolajczak, Marta; Hilferty, Lisa; Mitchell, Rory; Fleetwood-Walker, Sue M; Saunders, Philippa T K

    2017-03-10

    Endometriosis is an incurable gynecological disorder characterized by debilitating pain and the establishment of innervated endometriosis lesions outside the uterus. In a preclinical mouse model of endometriosis we demonstrated overexpression of the PGE2-signaling pathway (including COX-2, EP2, EP4) in endometriosis lesions, dorsal root ganglia (DRG), spinal cord, thalamus and forebrain. TRPV1, a PGE2-regulated channel in nociceptive neurons was also increased in the DRG. These findings support the concept that an amplification process occurs along the pain neuroaxis in endometriosis. We then tested TRPV1, EP2, and EP4 receptor antagonists: The EP2 antagonist was the most efficient analgesic, reducing primary hyperalgesia by 80% and secondary hyperalgesia by 40%. In this study we demonstrate reversible peripheral and central hyperalgesia in mice with induced endometriosis.

  3. Detection and Biological Activities of Carboxyethylpyrrole Ethanolamine Phospholipids (CEP-EPs)

    PubMed Central

    2015-01-01

    Oxidation of docosahexaenoate phospholipids produces 4-hydroxy-7-oxo-hept-5-eonyl phospholipids (HOHA-PLs) that react with protein lysyl ε-amino residues to generate 2-ω-carboxyethylpyrrole (CEP) derivatives, endogenous factors that induce angiogenesis in the retina and tumors. It seemed likely, but remained unproven, that HOHA-PLs react with ethanolamine phospholipids (EPs) in vivo to generate CEP-EPs. We now show that CEP-EPs are present in human blood at 4.6-fold higher levels in age-related macular degeneration plasma than in normal plasma. We also show that CEP-EPs are pro-angiogenic, inducing tube formation by human umbilical vein endothelial cells by activating Toll-like receptor 2. CEP-EP levels may be a useful biomarker for clinical assessment of AMD risk and CEP-associated tumor progression and a tool for monitoring the efficacy of therapeutic interventions. PMID:25380349

  4. EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis

    PubMed Central

    Greaves, Erin; Horne, Andrew W.; Jerina, Helen; Mikolajczak, Marta; Hilferty, Lisa; Mitchell, Rory; Fleetwood-Walker, Sue M.; Saunders, Philippa T. K.

    2017-01-01

    Endometriosis is an incurable gynecological disorder characterized by debilitating pain and the establishment of innervated endometriosis lesions outside the uterus. In a preclinical mouse model of endometriosis we demonstrated overexpression of the PGE2-signaling pathway (including COX-2, EP2, EP4) in endometriosis lesions, dorsal root ganglia (DRG), spinal cord, thalamus and forebrain. TRPV1, a PGE2-regulated channel in nociceptive neurons was also increased in the DRG. These findings support the concept that an amplification process occurs along the pain neuroaxis in endometriosis. We then tested TRPV1, EP2, and EP4 receptor antagonists: The EP2 antagonist was the most efficient analgesic, reducing primary hyperalgesia by 80% and secondary hyperalgesia by 40%. In this study we demonstrate reversible peripheral and central hyperalgesia in mice with induced endometriosis. PMID:28281561

  5. Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.

    PubMed

    Bastien, L; Sawyer, N; Grygorczyk, R; Metters, K M; Adam, M

    1994-04-22

    A cDNA clone encoding the human prostaglandin (PG) E2 receptor EP2 subtype has been isolated from a human lung cDNA library. The 1.9-kilobase pair cDNA, hEP2, encodes for a 488-amino acid protein with a predicted molecular mass of 53,115 and has the seven putative transmembrane domains characteristic of G protein-coupled receptors. The specific binding of [3H]PGE2 to COS cell membranes transfected with the hEP2 cDNA was of high affinity with an equilibrium dissociation constant (Kd) of 1 nM and the rank order of potency for prostaglandins in competition for [3H]PGE2 specific binding was PGE1 = PGE2 > iloprost > PGF2 alpha > PGD2. In competition studies using more selective prostanoid-receptor agonist and antagonists, the [3H]PGE2 specific binding was competed by MB28767, an EP3 agonist, but not by the EP1-preferring antagonists AH6809 and SC19220, or by the EP2 agonist butaprost. Electrophysiological studies of Xenopus oocytes co-injected with hEP2 and cystic fibrosis transmembrane conductance regulator (cAMP-activated Cl- channel) cDNAs detected PGE2-specific inward Cl- currents, demonstrating that the hEP2 cDNA encoded a functional receptor which produced an increase in cAMP levels. Thus, we have cloned the human EP2 receptor subtype which is functionally coupled to increase in cAMP. Northern blot analysis showed that hEP2 is expressed as a 3.8-kilobase mRNA in a number of human tissues with the highest expression levels present in the small intestine.

  6. The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia.

    PubMed

    Chang, Sung-Hee; Ai, Youxi; Breyer, Richard M; Lane, Timothy F; Hla, Timothy

    2005-06-01

    Expression of cyclooxygenase 2 (COX-2) in breast cancer correlates with poor prognosis, and COX-2 enzyme inhibitors reduce breast cancer incidence in humans. We recently showed that COX-2 overexpression in the mammary gland of transgenic mice induced mammary cancer. Because prostaglandin E2 (PGE2) is the major eicosanoid and because the EP2 subtype of the PGE2 receptor is highly expressed in the mammary tumors, we tested if this G protein-coupled receptor is required for tumorigenesis. We crossed the MMTV-COX-2 transgenic mice with Ep2-/- mice and studied tumor development in bigenic mice. Lack of EP2 receptor strongly suppressed COX-2-induced effects such as precocious development of the mammary gland in virgins and the development of mammary hyperplasia in multiparous female mice. Interestingly, the expression of amphiregulin, a potent mammary epithelial cell growth factor was down regulated in mammary glands of Ep2-/- mice. Total cyclic AMP (cAMP) levels were reduced in Ep2-/- mammary glands suggesting that PGE2 signaling via the EP2 receptor activates the Gs/cAMP/protein kinase A pathway. In mammary tumor cell lines, expression of the EP2 receptor followed by treatment with CAY10399, an EP2-specific agonist, strongly induced amphiregulin mRNA levels in a protein kinase A-dependent manner. These data suggest that PGE2 signaling via the EP2 receptor in mammary epithelial cells regulate mammary gland hyperplasia by the cAMP-dependent induction of amphiregulin. Inhibition of the EP2 pathway in the mammary gland may be a novel approach in the prevention and/or treatment of mammary cancer.

  7. The receptor EP3 to PGE2: A rational target to prevent atherothrombosis without inducing bleeding.

    PubMed

    Mawhin, Marie-Anne; Tilly, Peggy; Fabre, Jean-Etienne

    2015-09-01

    The prostanoid E2 (PGE2) is known to modulate the aggregative response of platelets to their conventional agonists such as ADP, TXA2, thrombin or collagen. Through the activation of its receptor EP3, PGE2 sensitizes platelets to their agonists but also inhibits them through its two other receptors, EP2 and EP4. In mice, the net result of these opposed actions is the EP3-mediated potentiation of platelet aggregation and the in vivo aggravation of murine atherothrombosis. Since the pathway PGE2/EP3 is not involved in murine hemostasis, we propose a "platelet EP3 paradigm" to describe this apparently paradoxical association between the facilitating impact on atherothrombosis and the unaltered hemostasis. Consistent with this paradigm, a drug blocking EP3 dramatically decreased atherothrombosis without inducing bleeding in mice. In humans, several studies did not agree on the effect of PGE2 on platelets. Reinterpreting these data with the notion of "potentiation window" and taking the platelet initial cAMP level into account reconciled these inconsistent results. Thereby, the in vitro potentiating effect of PGE2 on human platelets becomes clear. In addition, the EP3 blocking drug DG-041 abrogated the potentiating effect of PGE2 in whole human blood but did not prolong bleeding times in volunteers. Thus, the murine "platelet EP3 paradigm" would apply to humans if the aggravating role of PGE2 on atherothrombosis is shown in patients. Therefore, testing an EP3 blocker in a phase III trial would be of high interest to fulfill the unmet medical need which is to control atherothrombosis without impacting hemostasis and thus to improve the prevention of myocardial infarction.

  8. Influences of influent carbon source on extracellular polymeric substances (EPS) and physicochemical properties of activated sludge.

    PubMed

    Ye, Fenxia; Peng, Ge; Li, Ying

    2011-08-01

    It is necessary to understand the bioflocculation, settling and dewatering characteristics in the activated sludge process in order to establish more efficient operational strategies. The influences of carbon source on the extracellular polymeric substances (EPS) and flocculation, settling and dewatering properties of the activated sludge were investigated. Laboratory-scale completely mixed activated sludge processes were used to grow the activated sludge with different carbon sources of starch, glucose and sodium acetate. The sludge fed with acetate had highest loosely bound EPS (LB-EPS) and that fed with starch lowest. The amount of tightly bound EPS (TB-EPS), protein content in LB-EPS, polysaccharide content and protein contents in TB-EPS, were independent of the influent carbon source. The polysaccharide content in LB-EPS of the activated sludge fed with sodium acetate was lower slightly than those of starch and glucose. The sludge also had a nearly consistent flocs size and the sludge volume index (SVI) value. ESS content of the sludge fed with sodium acetate was higher initially, although it was similar to those fed with glucose and starch finally. However, the specific resistance to filtration and normalized capillary suction time fluctuated first, but finally were stable at around 5.0×10(8)mkg(-1) and 3.5 s Lg(-1) SS, respectively. Only the protein content in LB-EPS weakly correlated with the flocs size and SVI of the activated sludge. But there was no correlation between any other EPS contents or components and the physicochemical properties of the activated sludge.

  9. Functional pharmacological evidence for EP2 and EP4 prostanoid receptors in immortalized human trabecular meshwork and non-pigmented ciliary epithelial cells.

    PubMed

    Crider, J Y; Sharif, N A

    2001-02-01

    The aim of these studies was to characterize the molecular pharmacology of the prostanoid receptors positively coupled to stimulation of adenylyl cyclase activity in immortalized human trabecular meshwork (TM-3) cells and to compare these results with that of the receptors in immortalized human nonpigmented epithelial (NPE) cells. In general, the TM-3 and NPE cells showed a similar profile with respect to their responses to various prostaglandin (PG) receptor agonists. The rank order of potency (EC50; means +/- SEM) for these compounds in the TM-3 cells was: PGE2 (124 +/- 21 nM) > 13,14-dihydro-PGE1 (430 +/- 110 nM) = PGE1 (522 +/- 345 nM) > 11-deoxy-PGE1 (1063 +/- 118 nM) = 16,16-dimethyl-PGE2 (1776 +/- 460 nM) = butaprost (1920 +/- 527 nM) > PGD2 = PGI2 = PGF2alpha (n = 3 - 12). While the agonist profile indicated the presence of EP2 receptors, the effects of the EP4 receptor antagonists suggested the additional expression of EP4 receptors in both of these cells. Thus, the EP4 receptor antagonist, AH23848B, at a concentration of 30 microM, caused a dextral shift in the PGE2 concentration-response curves in both TM-3 and NPE cells coupled with a 20-28% decrease in the maximal response of PGE2, indicating apparent noncompetitive antagonism profiles. The antagonist potency of AH23848B in these cells was: Kb = 38.4 +/- 14.8 microM and 23.5 +/- 4.5 microM; -log Kb = 4.7. The other EP4 receptor antagonist, AH22921 (-log Kb = 4.1 - 4.7), was weaker than AH23848B. Taken together, these pharmacological studies have shown than TM-3 and NPE cells apparently contain functional EP2 and EP4 prostanoid receptors positively coupled to adenylyl cyclase.

  10. Relation between EPS adherence, viscoelastic properties, and MBR operation: Biofouling study with QCM-D.

    PubMed

    Sweity, Amer; Ying, Wang; Ali-Shtayeh, Mohammed S; Yang, Fei; Bick, Amos; Oron, Gideon; Herzberg, Moshe

    2011-12-01

    Membrane fouling is one of the main constraints of the wide use of membrane bioreactor (MBR) technology. The biomass in MBR systems includes extracellular polymeric substances (EPS), metabolic products of active microbial secretion that adversely affect the membrane performance. Solids retention time (SRT) in the MBR is one of the most important parameters affecting membrane fouling in MBR systems, where fouling is minimized at optimal SRT. Among the operating parameters in MBR systems, SRT is known to strongly influence the ratio of proteins to polysaccharides in the EPS matrix. In this study, we have direct evidence for changes in EPS adherence and viscoelastic properties due to changes in the sludge removal rate that strongly correlate with the membrane fouling rate and EPS composition. EPS were extracted from a UF membrane in a hybrid growth MBR operated at sludge removal rates of 59, 35.4, 17.7, and 5.9 L day(-1) (corresponding SRT of 3, 5, 10, and 30 days, respectively). The EPS adherence and adsorption kinetics were carried out in a quartz crystal microbalance with dissipation monitoring (QCM-D) technology in several adsorption measurements to a gold sensor coated with Polyvinylidene Fluoride (PVDF). EPS adsorption to the sensor surface is characterized by a decrease of the oscillation frequency and an increase in the dissipation energy of the sensor during parallel flow of aqueous media, supplemented with EPS, above the sensor surface. The results from these experiments were further modeled using the Voigt based model, in which the thickness, shear modulus, and shear viscosity values of the adsorbed EPS layers on the PVDF crystal were calculated. The observations in the QCM-D suggested that the elevated fouling of the UF membrane is due to higher adherence of the EPS as well as reduction in viscosity and elasticity of the EPS adsorbed layer and elevation of the EPS fluidity. These results corroborate with confocal laser scanning microscopy (CLSM) image

  11. Conformal symmetry and the Balitsky-Kovchegov equation

    SciTech Connect

    Gubser, Steven S.

    2011-10-15

    Solutions to the Balitsky-Kovchegov equation are considered which respect an SO(3) subgroup of the conformal group. The symmetry dictates a specific dependence of the saturation scale on the impact parameter. Applications to deep inelastic scattering are considered.

  12. Electromagnetic studies of nuclear structure and reactions

    SciTech Connect

    Hersman, F.W.; Dawson, J.F.; Heisenberg, J.H.; Calarco, J.R.

    1990-06-01

    This report contains papers on the following topics: giant resonance studies; deep inelastic scattering studies; high resolution nuclear structure work; and relativistic RPA; and field theory in the Schroedinger Representation.

  13. TMD Evolution at Moderate Hard Scales

    SciTech Connect

    Rogers, Ted; Collins, John C.

    2016-01-01

    We summarize some of our recent work on non-perturbative transverse momentum dependent (TMD) evolution, emphasizing aspects that are necessary for dealing with moderately low scale processes like semi-inclusive deep inelastic scattering.

  14. Twist-3 spin observables for single-hadron production in DIS

    SciTech Connect

    Gamberg, Leonard P.; Kanazawa, Koichi; Kang, Zhong-Bo; Metz, Andreas; Pitonyak, Daniel A.; Prokudin, Alexei; Schlegel, Marc

    2015-09-01

    Recently, three twist-3 spin asymmetries for single-inclusive hadron production in deep-inelastic lepton-nucleon scattering have been computed using collinear factorization and the leading order approximation. Here we summarize the main findings of these studies.

  15. THE ECLIPSING SYSTEM EP ANDROMEDAE AND ITS CIRCUMBINARY COMPANIONS

    SciTech Connect

    Lee, Jae Woo; Hinse, Tobias Cornelius; Park, Jang-Ho E-mail: tchinse@gmail.com

    2013-04-15

    We present new long-term CCD photometry for EP And acquired during the period 2007-2012. The light curves display total eclipses at primary minima and season-to-season light variability. Our synthesis for all available light curves indicates that the eclipsing pair is a W-type overcontact binary with parameters of q = 2.578, i = 83. Degree-Sign 3, {Delta}T = 27 K, f = 28%, and l{sub 3} = 2%-3%. The asymmetric light curves in 2007 were satisfactorily modeled by a cool spot on either of the eclipsing components from a magnetic dynamo. Including our 95 timing measurements, a total of 414 times of minimum light spanning about 82 yr was used for a period study. A detailed analysis of the eclipse timing diagram revealed that the orbital period of EP And has varied as a combination of an upward-opening parabola and two periodic variations, with cycle lengths of P{sub 3} = 44.6 yr and P{sub 4} = 1.834 yr and semi-amplitudes of K{sub 3} = 0.0100 days and K{sub 4} = 0.0039 days, respectively. The observed period increase at a fractional rate of +1.39 Multiplication-Sign 10{sup -10} is in excellent agreement with that calculated from the W-D code and can be plausibly explained by some combination of mass transfer from the primary to the secondary star and angular momentum loss due to magnetic braking. The most reasonable explanation for both cycles is a pair of light-travel-time effects driven by the possible existence of a third and fourth component with projected masses of M{sub 3} = 0.25 M{sub Sun} and M{sub 4} = 0.90 M{sub Sun }. The more massive companion could be revealed using high-resolution spectroscopic data extending over the course of a few years and could also be a binary itself. It is possible that the circumbinary objects may have played an important role in the formation and evolution of the eclipsing pair, which would cause it to have a short initial orbital period and thus evolve into an overcontact configuration by angular momentum loss.

  16. QED radiative effects in the processes of exclusive photon electroproduction from polarized protons with the next-to-leading accuracy

    SciTech Connect

    Akushevich, Igor V.; Ilyichev, Alexander; Shumeiko, Nikolai M

    2014-08-01

    Radiative effects in the electroproduction of photons in polarized ep-scattering are calculated with the next-to-leading (NLO) accuracy. The contributions of loops and two photon emission were presented in analytical form. The covariant approach of Bardin and Shumeiko was used to extract the infrared divergence. All contributions to the radiative correction were presented in the form of the correction to the leptonic tensor thus allowing for further applications in other experiments, e.g., deep inelastic scattering. The radiative corrections (RC) to the cross sections and polarization asymmetries were analyzed numerically for kinematical conditions of the current measurement at Jefferson Lab. Specific attention was paid on analyzing kinematical conditions for the process with large radiative effect when momenta of two photons in the final state are collinear to momenta of initial and final electrons, respectively.

  17. 3,4-Disubstituted indole acylsulfonamides: a novel series of potent and selective human EP3 receptor antagonists.

    PubMed

    Zhou, Nian; Zeller, Wayne; Krohn, Michael; Anderson, Herb; Zhang, Jun; Onua, Emmanuel; Kiselyov, Alex S; Ramirez, Jose; Halldorsdottir, Gułrún; Andrésson, Thornorkell; Gurney, Mark E; Singh, Jasbir

    2009-01-01

    A series of potent and selective EP(3) receptor antagonists are described. Utilizing a pharmacophore model developed for the EP(3) receptor, a series of 3,4-disubstituted indoles were shown to be high affinity ligands for this target. These compounds showed high selectivity over IP, FP and other EP receptors and are potent antagonists in functional assays.

  18. 30 CFR 550.235 - If a State objects to the EP's coastal zone consistency certification, what can I do?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false If a State objects to the EP's coastal zone... EP's coastal zone consistency certification, what can I do? If an affected State objects to the coastal zone consistency certification accompanying your proposed EP within the timeframe prescribed...

  19. 30 CFR 550.235 - If a State objects to the EP's coastal zone consistency certification, what can I do?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false If a State objects to the EP's coastal zone... EP's coastal zone consistency certification, what can I do? If an affected State objects to the coastal zone consistency certification accompanying your proposed EP within the timeframe prescribed...

  20. 30 CFR 550.235 - If a State objects to the EP's coastal zone consistency certification, what can I do?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false If a State objects to the EP's coastal zone... EP's coastal zone consistency certification, what can I do? If an affected State objects to the coastal zone consistency certification accompanying your proposed EP within the timeframe prescribed...

  1. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA... in June 2011 (for plan year 2012), MA organizations seeking reimbursement for qualifying MA EPs...

  2. Biosynthesis of selenium rich exopolysaccharide (Se-EPS) by Pseudomonas PT-8 and characterization of its antioxidant activities.

    PubMed

    Ye, Shuhong; Zhang, Jiajia; Liu, Zhaofang; Zhang, Yu; Li, Jiang; Li, Yao Olive

    2016-05-20

    Biosynthesis of organo-selenium is achieved by submerged fermentation of selenium-tolerant Pseudomonas PT-8. The end product of metabolic process is selenium-bearing exopolysaccharide (Se-EPS), which contains a higher content of uronic acid than the exopolysaccharide (EPS) by the strain without selenium in the culture medium. Selenium content in Se-EPS reached a maximum yield of 256.7 mg/kg when using an optimized culture condition. Crude Se-EPS was purified into two fractions-a pH neutral Se-EPS-1 and an acidic Se-EPS-2. Structure and chemical composition of Se-EPS-2 were investigated by chromatographic analyses. Results showed that Se-EPS-2 was a homogenous polysaccharide with molecular weight of 7.3 kDa, consisting of monosaccharides, rhamnose, arabinose, xylose, mannose, glucose and galactose with a molar ratio of 19.58:19.28:5.97:18.99:23.70:12.48, respectively. Compared to the EPS, the content of rhamnose in Se-EPS increased and molecular weight decreased. The Se-EPS had strong scavenging actions on DPPH•, •OH and •O2(-), which is much higher than the EPS.

  3. EpCAM-selective elimination of carcinoma cells by a novel MAP-based cytolytic fusion protein.

    PubMed

    Hristodorov, Dmitrij; Amoury, Manal; Mladenov, Radoslav; Niesen, Judith; Arens, Katharina; Berges, Nina; Hein, Lea; Di Fiore, Stefano; Pham, Anh-Tuan; Huhn, Michael; Helfrich, Wijnand; Fischer, Rainer; Thepen, Theo; Barth, Stefan

    2014-09-01

    In normal epithelia, the epithelial cell adhesion molecule (EpCAM) expression is relatively low and only present at the basolateral cell surface. In contrast, EpCAM is aberrantly overexpressed in various human carcinomas. Therefore, EpCAM is considered to be a highly promising target for antibody-based cancer immunotherapy. Here, we present a new and fully human cytolytic fusion protein (CFP), designated "anti-EpCAM(scFv)-MAP," that is comprised of an EpCAM-specific antibody fragment (scFv) genetically fused to the microtubule-associated protein tau (MAP). Anti-EpCAM(scFv)-MAP shows potent EpCAM-restricted proapoptotic activity toward rapidly proliferating carcinoma cells. In vitro assays confirmed that treatment with anti-EpCAM(scFv)-MAP resulted in the colocalization and stabilization of microtubules, suggesting that this could be the potential mode of action. Dose-finding experiments indicated that anti-EpCAM(scFv)-MAP is well tolerated in mice. Using noninvasive far-red in vivo imaging in a tumor xenograft mouse model, we further demonstrated that anti-EpCAM(scFv)-MAP inhibited tumor growth in vivo. In conclusion, our data suggest that anti-EpCAM(scFv)-MAP may be of therapeutic value for the targeted elimination of EpCAM(+) carcinomas.

  4. EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer

    PubMed Central

    Schneck, Helen; Gierke, Berthold; Uppenkamp, Frauke; Behrens, Bianca; Niederacher, Dieter; Stoecklein, Nikolas H.; Templin, Markus F.; Pawlak, Michael; Fehm, Tanja; Neubauer, Hans

    2015-01-01

    Circulating tumor cells (CTCs) are the potential precursors of metastatic disease. Most assays established for the enumeration of CTCs so far–including the gold standard CellSearch—rely on the expression of the cell surface marker epithelial cell adhesion molecule (EpCAM). But, these approaches may not detect CTCs that express no/low levels of EpCAM, e.g. by undergoing epithelial-to-mesenchymal transition (EMT). Here we present an enrichment strategy combining different antibodies specific for surface proteins and extracellular matrix (ECM) components to capture an EpCAMlow/neg cell line and EpCAMneg CTCs from blood samples of breast cancer patients depleted for EpCAM-positive cells. The expression of respective proteins (Trop2, CD49f, c-Met, CK8, CD44, ADAM8, CD146, TEM8, CD47) was verified by immunofluorescence on EpCAMpos (e.g. MCF7, SKBR3) and EpCAMlow/neg (MDA-MB-231) breast cancer cell lines. To test antibodies and ECM proteins (e.g. hyaluronic acid (HA), collagen I, laminin) for capturing EpCAMneg cells, the capture molecules were first spotted in a single- and multi-array format onto aldehyde-coated glass slides. Tumor cell adhesion of EpCAMpos/neg cell lines was then determined and visualized by Coomassie/MitoTracker staining. In consequence, marginal binding of EpCAMlow/neg MDA-MB-231 cells to EpCAM-antibodies could be observed. However, efficient adhesion/capturing of EpCAMlow/neg cells could be achieved via HA and immobilized antibodies against CD49f and Trop2. Optimal capture conditions were then applied to immunomagnetic beads to detect EpCAMneg CTCs from clinical samples. Captured CTCs were verified/quantified by immunofluorescence staining for anti-pan-Cytokeratin (CK)-FITC/anti-CD45 AF647/DAPI. In total, in 20 out of 29 EpCAM-depleted fractions (69%) from 25 metastatic breast cancer patients additional EpCAMneg CTCs could be identified [range of 1–24 CTCs per sample] applying Trop2, CD49f, c-Met, CK8 and/or HA magnetic enrichment. Ep

  5. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells

    PubMed Central

    Kofler, David M.; Marson, Alexander; Dominguez-Villar, Margarita; Xiao, Sheng; Kuchroo, Vijay K.; Hafler, David A.

    2014-01-01

    Prostaglandin E2 (PGE2) promotes Th17 expansion while otherwise inhibiting other CD4+ T cell subsets. Here, we identified a PGE2-dependent pathway that induces pathogenic Th17 cells in autoimmune disease and is regulated by the transcription factor RORC. Compared with other CD4+ cell types from healthy subjects, there is a surprising lack of the prostaglandin receptor EP2 on Th17 cells; therefore, we examined the hypothesis that RORγt, which is highly expressed in Th17 cells, mediates EP2 downregulation. Chromatin immunoprecipitation followed by DNA sequencing revealed that RORγt binds directly to Ptger2 (the gene encoding EP2 receptor) in Th17 cells isolated from WT mice. In Th17 cells isolated from humans, RORC repressed EP2 by directly silencing PTGER2 transcription, and knock down of RORC restored EP2 expression in Th17 cells. Compared with Th17 cells from healthy individuals, Th17 cells from patients with MS exhibited reduced RORC binding to the PTGER2 promoter region, resulting in higher EP2 levels and increased expression of IFN-γ and GM-CSF. Finally, overexpression of EP2 in Th17 cells from healthy individuals induced a specific program of inflammatory gene transcription that produced a pathogenic Th17 cell phenotype. These findings reveal that RORC directly regulates the effects of PGE2 on Th17 cells, and dysfunction of this pathway induces a pathogenic Th17 cell phenotype. PMID:24812667

  6. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.

    PubMed

    Kofler, David M; Marson, Alexander; Dominguez-Villar, Margarita; Xiao, Sheng; Kuchroo, Vijay K; Hafler, David A

    2014-06-01

    Prostaglandin E2 (PGE2) promotes Th17 expansion while otherwise inhibiting other CD4+ T cell subsets. Here, we identified a PGE2-dependent pathway that induces pathogenic Th17 cells in autoimmune disease and is regulated by the transcription factor RORC. Compared with other CD4+ cell types from healthy subjects, there is a surprising lack of the prostaglandin receptor EP2 on Th17 cells; therefore, we examined the hypothesis that RORγt, which is highly expressed in Th17 cells, mediates EP2 downregulation. Chromatin immunoprecipitation followed by DNA sequencing revealed that RORγt binds directly to Ptger2 (the gene encoding EP2 receptor) in Th17 cells isolated from WT mice. In Th17 cells isolated from humans, RORC repressed EP2 by directly silencing PTGER2 transcription, and knock down of RORC restored EP2 expression in Th17 cells. Compared with Th17 cells from healthy individuals, Th17 cells from patients with MS exhibited reduced RORC binding to the PTGER2 promoter region, resulting in higher EP2 levels and increased expression of IFN-γ and GM-CSF. Finally, overexpression of EP2 in Th17 cells from healthy individuals induced a specific program of inflammatory gene transcription that produced a pathogenic Th17 cell phenotype. These findings reveal that RORC directly regulates the effects of PGE2 on Th17 cells, and dysfunction of this pathway induces a pathogenic Th17 cell phenotype.

  7. Clinicopathology of EpCAM and EGFR in Human Epithelial Ovarian Carcinoma

    PubMed Central

    Zheng, Jingying; Zhao, Lijing; Wang, Yi; Zhao, Shuhua; Cui, Manhua

    2017-01-01

    Abstract The objective of this study was to explore the expression of EpCAM and EGFR in human epithelial ovarian cancer (EOC) and their correlation with clinicopathological parameters. The protein expression levels of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR) were evaluated by immunohistochemistry in formalin-fixed paraffin-embedded specimens from 30 patients with epithelial ovarian carcinoma and 15 normal ovary tissues. Clinicopathological characteristics were gathered by retrospective review of the patients’ files. The correlation between EpCAM and EGFR expression, as well as their association with clinical pathological parameters were investigated. The SPSS 17.0 package was used to perform statistical analyses. The positive expression rates of EpCAM and EGFR were significantly elevated in epithelial ovarian cancer tissues than in normal ovary tissues. The positive expressions of EpCAM and EGFR in EOC were associated with International Federation of Gynecology and Obstetrics (FIGO) stage and tumor differentiation, lymph node metastasis. Spearman correlation analysis demonstrated a significant positive association between EpCAM and EGFR expression in EOC. The co-expression of EpCAM and EGFR may play an important role in the carcinogenesis of EOC and might provide a promising molecular therapeutic target.

  8. EP4 and EP2 receptor activation of protein kinase A by prostaglandin E2 impairs macrophage phagocytosis of Clostridium sordellii

    PubMed Central

    Rogers, Lisa M.; Thelen, Tennille; Fordyce, Krystle; Bourdonnay, Emilie; Lewis, Casey; Yu, Han; Zhang, Junyong; Xie, Jingli; Serezani, Carlos H.; Peters-Golden, Marc; Aronoff, David M.

    2013-01-01

    Problem Clostridium sordellii causes endometrial infections but little is known regarding host defenses against this pathogen. Method of Study We tested the hypothesis that the immunoregulatory lipid prostaglandin (PG) E2 suppresses human macrophage clearance of C. sordellii through receptor-induced increases in intracellular cAMP. The THP-1 macrophage cell line was used to quantify C. sordellii phagocytosis. Results PGE2 increased cAMP levels, activated protein kinase A (PKA), and inhibited the class A scavenger receptor-dependent phagocytosis of C. sordellii. Activation of the EP2 and EP4 receptors increased intracellular cAMP and inhibited phagocytosis, with evidence favoring a more important role for EP4 over EP2. This was supported by EP receptor expression data and the use of pharmacological receptor antagonists. In addition, the PKA isoform RI appeared to be more important than RII in mediating the suppression of ingestion of C. sordellii. Conclusions The endogenous lipid mediator PGE2 impairs human innate immune responses against C. sordellii. PMID:23902376

  9. Ca2+ signals evoked by histamine H1 receptors are attenuated by activation of prostaglandin EP2 and EP4 receptors in human aortic smooth muscle cells

    PubMed Central

    Pantazaka, Evangelia; Taylor, Emily J A; Bernard, William G; Taylor, Colin W

    2013-01-01

    Background and Purpose Histamine and prostaglandin E2 (PGE2), directly and via their effects on other cells, regulate the behaviour of vascular smooth muscle (VSM), but their effects on human VSM are incompletely resolved. Experimental Approach The effects of PGE2 on histamine-evoked changes in intracellular free Ca2+ concentration ([Ca2+]i) and adenylyl cyclase activity were measured in populations of cultured human aortic smooth muscle cells (ASMCs). Selective ligands of histamine and EP receptors were used to identify the receptors that mediate the responses. Key Results Histamine, via H1 receptors, stimulates an increase in [Ca2+]i that is entirely mediated by activation of inositol 1,4,5-trisphosphate receptors. Selective stimulation of EP2 or EP4 receptors attenuates histamine-evoked Ca2+ signals, but the effects of PGE2 on both Ca2+ signals and AC activity are largely mediated by EP2 receptors. Conclusions and Implications Two important inflammatory mediators, histamine via H1 receptors and PGE2 acting largely via EP2 receptors, exert opposing effects on [Ca2+]i in human ASMCs. PMID:23638853

  10. Efficiency of the EPS emulsifier produced by Ochrobactrum anthropi in different hydrocarbon bioremediation assays.

    PubMed

    Calvo, C; Silva-Castro, G A; Uad, I; García Fandiño, C; Laguna, J; González-López, J

    2008-11-01

    Ochrobactrum anthropi strain AD2 was isolated from the waste water treatment plant of an oil refinery and was identified by analysis of the sequence of the gene encoding 16S rDNA. This bacterium produced exopolysaccharides in glucose nutrient broth media supplemented with various hydrocarbons (n-octane, mineral light and heavy oils and crude oils). The exopolysaccharide AD2 (EPS emulsifier) synthesized showed a wide range of emulsifying activity but none of them had surfactant activity. Yield production varied from 0.47 to 0.94 g of EPS l(-1) depending on the hydrocarbon added. In the same way, chemical composition and emulsification activity of EPS emulsifier varied with the culture conditions. Efficiency of the EPS emulsifier as biostimulating agent was assayed in soil microcosms and experimental biopiles. The AD2 biopolymer was added alone or combined with commercial products frequently used in oil bioremediation such as inorganic NPK fertilizer and oleophilic fertilizer (S200 C). Also, its efficiency was tested in mixture with activated sludge from an oil refinery. In soil microcosms supplemented with S200 C+EPS emulsifier as combined treatment, indigenous microbial populations as well as hydrocarbon degradation was enhanced when compared with microcosms treated with NPK fertilizer or EPS emulsifier alone. In the same way EPS emulsifier stimulated the bioremediation effect of S200 C product, increasing the number of bacteria and decreasing the amount of hydrocarbon remained. Finally, similar effects were obtained in biopile assays amended with EPS emulsifier plus activated sludge. Our results suggest that the bioemulsifier EPS emulsifier has interesting properties for its application in environment polluted with oil hydrocarbon compounds and may be useful for bioremediation purposes.

  11. The axisymmetric envelopes of RS Cnc and EP Aqr

    NASA Astrophysics Data System (ADS)

    Le Bertre, T.; Hoai, D. T.; Nhung, P. T.; Winters, J. M.

    2016-12-01

    We report on observations obtained at IRAM on two semi-regular variable Asymptotic Giant Branch (AGB) stars, RS Cnc and EP Aqr, undergoing mass loss at an intermediate rate of ˜ 10^{-7} MȯMd. Interferometric data obtained with the Plateau-de-Bure interferometer (NOEMA) have been combined with On-The-Fly maps obtained with the 30-m telescope in the CO(1-0) and (2-1) rotational lines. The spectral maps of spatially resolved sources reveal an axisymmetric morphology in which matter is flowing out at a low velocity (˜ 2 kms) in the equatorial planes, and at a larger velocity (˜ 8 kms) along the polar axes. There are indications that this kind of morpho-kinematics is relatively frequent among stars at the beginning of their evolution on the Thermally-Pulsing AGB, in particular among those that show composite CO line profiles, and that it might be caused by the presence of a companion. We discuss the progress that could be expected for our understanding of the mass loss mechanisms in this kind of sources by increasing the spatial resolution of the observations with ALMA or NOEMA.

  12. GRB cosmology through the Ep,i-intensity correlation

    NASA Astrophysics Data System (ADS)

    Amati, L.; Sawant, D. S.; Della Valle, M.

    Despite they are not standard candles, the investigation of Gamma-Ray Bursts (GRBs) as a tool for measuring the geometry and expansion rate of the Universe is strongly motivated by their unique combination of huge luminosity, up to more than 10/53 erg/s, with a redshift distribution extending up to more than z = 9. In recent years, several attempts to exploit the correlation between the photon energy at which the vFv spec- trum peaks (peak energy) and the radiated energy (or luminosity) for standardizing GRBs and using them to estimate cosmological parameters have been made. These studies show that already with the present data-set, GRBs can provide a significant and independent confirmation of ΛM ˜ 0.3 for a flat ΛCDM. The investigation of the correlation of Ep,i with different intensity indicators (e.g., radiated energy, average and peak luminosity, bolometric vs. monochromatic quantities, etc.) both in terms of intrinsic dispersion of and accuracy for estimating ΛM further confirms its reliability and effectiveness for both GRB physics and their standardization for cosmology. Current (e.g., Swift, Fermi/GBM, Konus-WIND) and forthcoming GRB experiments (e.g., CALET/GBM, SVOM, Lomonosov/UFFO) will allow us to constrain ΛM with an accuracy comparable to that currently exhibited by Type Ia supernovae and to study the properties of dark energy and their evolution with time.

  13. Introduction to the study of collisions between heavy nuclei

    SciTech Connect

    Bayman, B.F.

    1980-01-01

    Current investigations concerning the collisions of nuclei governed by small de Broglie wavelengths are reviewed. The wave packets localize nuclei in regions small compared to their diameters. Cross sections are examined for potential scattering, elastic scattering, quasi-molecular states, peripheral particle-transfer reactions, fusion, and deep inelastic collisions. Theories of fusion and deep inelastic collisions are summarized. This paper is in the nature of a review-tutorial. 45 references, 51 figures, 2 tables. (RWR)

  14. EP3 Receptor Isoforms are Differentially Expressed in Subpopulations of Primate Granulosa Cells and Couple to Unique G-Proteins

    PubMed Central

    Kim, Soon Ok; Dozier, Brandy L.; Kerry, Julie A.; Duffy, Diane M.

    2013-01-01

    Prostaglandin E2 produced within the ovarian follicle is necessary for ovulation. Prostaglandin E2 is recognized by four distinct G-protein coupled receptors. Among them, PTGER3 (also known as EP3) is unique in that mRNA splicing generates multiple isoforms. Each isoform has a distinct amino acid composition in the C-terminal region, which is involved in G-protein coupling. To determine if monkey EP3 isoforms couple to different G-proteins, each EP3 isoform was expressed in Chinese hamster ovary (CHO) cells, and intracellular signals were examined after stimulation with the EP3 agonist sulprostone. Stimulation of EP3 isoform 5 (EP3-5) reduced cyclic adenosine monophosphate (cAMP) in a pertussis toxin-sensitive manner, indicating involvement of Gαi. Stimulation of EP3-9 increased cAMP, which was reduced by the general G-protein inhibitor GDP-β-S, and also increased intracellular calcium, which was reduced by pertussis toxin and GDP-β-S. So, EP3-9 likely couples to both Gαs and a pertussis toxin-sensitive G-protein to regulate intracellular signals. Stimulation of EP3-14 increased cAMP, which was further increased by pertussis toxin, so EP3-14 likely regulates cAMP via multiple G-proteins. Granulosa cell expression of all EP3 isoforms increased in response to an ovulatory dose of hCG. Two EP3 isoforms were differentially expressed in functional subpopulations of granulosa cells. EP3-5 was low in granulosa cells at the follicle apex while EP3-9 was high in cumulus granulosa cells. Differential expression of EP3 isoforms may yield different intracellular responses to prostaglandin E2 in granulosa cell subpopulations, contributing to the different roles played by granulosa cell subpopulations in the process of ovulation. PMID:24062570

  15. Overview of the 2014 Edition of the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook)

    SciTech Connect

    John D. Bess; J. Blair Briggs; Jim Gulliford; Ian Hill

    2014-10-01

    The International Reactor Physics Experiment Evaluation Project (IRPhEP) is a widely recognized world class program. The work of the IRPhEP is documented in the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook). Integral data from the IRPhEP Handbook is used by reactor safety and design, nuclear data, criticality safety, and analytical methods development specialists, worldwide, to perform necessary validations of their calculational techniques. The IRPhEP Handbook is among the most frequently quoted reference in the nuclear industry and is expected to be a valuable resource for future decades.

  16. Exogenous arachidonic acid mediates permeability of human brain microvessel endothelial cells through prostaglandin E2 activation of EP3 and EP4 receptors.

    PubMed

    Dalvi, Siddhartha; Nguyen, Hieu H; On, Ngoc; Mitchell, Ryan W; Aukema, Harold M; Miller, Donald W; Hatch, Grant M

    2015-12-01

    The blood-brain barrier, formed by microvessel endothelial cells, is the restrictive barrier between the brain parenchyma and the circulating blood. Arachidonic acid (ARA; 5,8,11,14-cis-eicosatetraenoic acid) is a conditionally essential polyunsaturated fatty acid [20:4(n-6)] and is a major constituent of brain lipids. The current study examined the transport processes for ARA in confluent monolayers of human brain microvascular endothelial cells (HBMEC). Addition of radioactive ARA to the apical compartment of HBMEC cultured on Transwell(®) inserts resulted in rapid incorporation of radioactivity into the basolateral medium. Knock down of fatty acid transport proteins did not alter ARA passage into the basolateral medium as a result of the rapid generation of prostaglandin E2 (PGE2 ), an eicosanoid known to facilitate opening of the blood-brain barrier. Permeability following ARA or PGE2 exposure was confirmed by an increased movement of fluorescein-labeled dextran from apical to basolateral medium. ARA-mediated permeability was attenuated by specific cyclooxygenase-2 inhibitors. EP3 and EP4 receptor antagonists attenuated the ARA-mediated permeability of HBMEC. The results indicate that ARA increases permeability of HBMEC monolayers likely via increased production of PGE2 which acts upon EP3 and EP4 receptors to mediate permeability. These observations may explain the rapid influx of ARA into the brain previously observed upon plasma infusion with ARA. The blood-brain barrier, formed by microvessel endothelial cells, is a restrictive barrier between the brain parenchyma and the circulating blood. Radiolabeled arachidonic acid (ARA) movement across, and monolayer permeability in the presence of ARA, was examined in confluent monolayers of primary human brain microvessel endothelial cells (HBMECs) cultured on Transwell(®) plates. Incubation of HBMECs with ARA resulted in a rapid increase in HBMEC monolayer permeability. The mechanism was mediated, in part

  17. Optics as Scattering

    ERIC Educational Resources Information Center

    di Francia, Giuliano Toraldo

    1973-01-01

    The art of deriving information about an object from the radiation it scatters was once limited to visible light. Now due to new techniques, much of the modern physical science research utilizes radiation scattering. (DF)

  18. A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.

    PubMed

    Croce, Assunta; Cassata, Giuseppe; Disanza, Andrea; Gagliani, Maria Cristina; Tacchetti, Carlo; Malabarba, Maria Grazia; Carlier, Marie-France; Scita, Giorgio; Baumeister, Ralf; Di Fiore, Pier Paolo

    2004-12-01

    Redundant gene function frequently hampers investigations of the physiological roles of mammalian proteins. This is the case for Eps8, a receptor tyrosine kinase (RTK) substrate that participates in the activation of the Rac-specific guanine nucleotide-exchange function of Sos1 (refs 2-5), thereby regulating actin remodelling by RTKs. EPS8-knockout mice, however, exhibit no evident phenotype, owing to the redundant function of three other EPS8-related genes. Here we show that in the nematode Caenorhabditis elegans, only one orthologue of the EPS8 gene exists, which gives rise to two alternatively spliced isoforms, EPS-8A and EPS-8B, differing at their carboxyl termini. In the nematode, eps-8 is essential for embryonic development. Furthermore, EPS-8A, but not EPS-8B, is specifically required for proper apical morphogenesis in the intestinal cells. This latter phenotype could be precisely correlated with a previously unknown actin barbed-end-capping activity, which is present in the C terminus of the EPS-8A isoform. Therefore, nematode genetics allowed not only the unmasking of distinct EPS-8-linked phenotypes, but also the definition of a novel function for this molecule in actin dynamics.

  19. Role of Prostaglandin Receptor EP2 in the Regulations of Cancer Cell Proliferation, Invasion, and Inflammation

    PubMed Central

    Dingledine, Ray

    2013-01-01

    Population studies, preclinical, and clinical trials suggest a role for cyclooxygenase-2 (COX-2, PTGS2) in tumor formation and progression. The downstream prostanoid receptor signaling pathways involved in tumorigenesis are poorly understood, although prostaglandin E2 (PGE2), a major COX-2 metabolite which is usually upregulated in the involved tissues, presumably plays important roles in tumor biology. Taking advantage of our recently identified novel selective antagonist for the EP2 (PTGER2) subtype of PGE2 receptor, we demonstrated that EP2 receptor activation could promote prostate cancer cell growth and invasion in vitro, accompanied by upregulation of the tumor-promoting inflammatory cytokines, such as IL-1β and IL-6. Our results suggest the involvement of prostaglandin receptor EP2 in cancer cell proliferation and invasion possibly via its inflammatory actions, and indicate that selective blockade of the PGE2-EP2 signaling pathway via small molecule antagonists might represent a novel therapy for tumorigenesis. PMID:23192657

  20. Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.

    PubMed

    Jiang, Jianxiong; Dingledine, Ray

    2013-02-01

    Population studies, preclinical, and clinical trials suggest a role for cyclooxygenase-2 (COX-2, PTGS2) in tumor formation and progression. The downstream prostanoid receptor signaling pathways involved in tumorigenesis are poorly understood, although prostaglandin E2 (PGE(2)), a major COX-2 metabolite which is usually upregulated in the involved tissues, presumably plays important roles in tumor biology. Taking advantage of our recently identified novel selective antagonist for the EP2 (PTGER2) subtype of PGE(2) receptor, we demonstrated that EP2 receptor activation could promote prostate cancer cell growth and invasion in vitro, accompanied by upregulation of the tumor-promoting inflammatory cytokines, such as IL-1β and IL-6. Our results suggest the involvement of prostaglandin receptor EP2 in cancer cell proliferation and invasion possibly via its inflammatory actions, and indicate that selective blockade of the PGE(2)-EP2 signaling pathway via small molecule antagonists might represent a novel therapy for tumorigenesis.

  1. Quick stimulation of Alcanivorax sp. by bioemulsificant EPS2003 on microcosm oil spill simulation

    PubMed Central

    Cappello, Simone; Genovese, Maria; Denaro, Renata; Santisi, Santina; Volta, Anna; Bonsignore, Martina; Mancini, Giuseppe; Giuliano, Laura; Genovese, Lucrezia; Yakimov, Michail M.

    2014-01-01

    Oil spill microcosms experiments were carried out to evaluate the effect of bioemulsificant exopolysaccharide (EPS2003) on quick stimulation of hydrocarbonoclastic bacteria. Early hours of oil spill, were stimulated using an experimental seawater microcosm, supplemented with crude oil and EPS2003 (SW+OIL+EPS2003); this system was monitored for 2 days and compared to control microcosm (only oil-polluted seawater, SW+OIL). Determination of bacterial abundance, heterotrophic cultivable and hydrocarbon-degrading bacteria were carried out. Community composition of marine bacterioplankton was determined by 16S rRNA gene clone libraries. Data obtained indicated that bioemulsificant addition stimulated an increase of total bacterial abundance and, in particular, selection of bacteria related to Alcanivorax genus; confirming that EPS2003 could be used for the dispersion of oil slicks and could stimulate the selection of marine hydrocarbon degraders thus increasing bioremediation process. PMID:25763036

  2. The impact of different operating conditions on membrane fouling and EPS production.

    PubMed

    Dvořák, Lukáš; Gómez, Marcel; Dvořáková, Markéta; Růžičková, Iveta; Wanner, Jiří

    2011-07-01

    The main goal of this research was to investigate how different factors influence membrane fouling. The impact of the different concentrations of activated sludge and the amount of extracellular polymer substances (EPS) were monitored. Two pilot plants with submerged membrane modules (hollow fiber and flat sheet) were operated and the raw wastewater was used. Humic substances were identified as the major components of EPS in the activated sludge (more than 34%) in both pilot plants. As the basic constituent in permeate, humic substances were identified as the most dominant components in the effluent (61%) in both pilot plants. Conversely, proteins were mostly analyzed in permeate and supernatant below the detection limit. The total amount of EPS [mgg(-1) (VSS)] was similar for concentrations of activated sludge 6, 10 and 14 g L(-1). Carbohydrates were identified as the component of EPS which tends most to clog membranes.

  3. 3. Historic American Buildings Survey, E.P. MacFarland, Photographer April 3, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, E.P. MacFarland, Photographer April 3, 1934, DETAIL OF CORNICE (SOUTH ELEVATION). - St. George's Rectory, Prospect & Greenwich Streets, Hempstead, Nassau County, NY

  4. 5. Historic American Buildings Survey, E.P. MacFarland, Photographer May 1, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, E.P. MacFarland, Photographer May 1, 1934, DETAIL OF MANTEL (PARLOR -- SOUTH WALL). - St. George's Rectory, Prospect & Greenwich Streets, Hempstead, Nassau County, NY

  5. 4. Historic American Buildings Survey, E.P. MacFarland, Photographer May 1, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, E.P. MacFarland, Photographer May 1, 1934, DETAIL OF STAIR (1st STORY -- REAR HALL). - St. George's Rectory, Prospect & Greenwich Streets, Hempstead, Nassau County, NY

  6. 4. Historic American Buildings Survey, E.P. MacFarland, Photographer April 23, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, E.P. MacFarland, Photographer April 23, 1934, DETAIL OF MANTEL (LIVING ROOM -- WEST WALL). - Edwin Forrest House, 436 West Twenty-second Street, New York County, NY

  7. 3. Historic American Buildings Survey, E.P. MacFarland, Photographer April 23, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, E.P. MacFarland, Photographer April 23, 1934, DETAIL OF DOORWAY (LIVING ROOM -- NORTH WALL). - Edwin Forrest House, 436 West Twenty-second Street, New York County, NY

  8. Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts

    PubMed Central

    Farrugia, Aaron J.; Calvo, Fernando

    2017-01-01

    ABSTRACT Rho family GTPases such as Cdc42 are key regulators of essential cellular processes through their effects on cytoskeletal dynamics, signaling and gene expression. Rho GTPases modulate these functions by engaging a wide variety of downstream effectors. Among these effectors is the largely understudied Cdc42EP/BORG family of Cdc42 effectors. BORG proteins have been linked to actin and septin regulation, but their role in development and disease is only starting to emerge. Recently, Cdc42EP3/BORG2 was shown to coordinate actin and septin cytoskeleton rearrangements in cancer-associated fibroblasts (CAFs). Interestingly, Cdc42EP3 expression potentiated cellular responses to mechanical stimulation leading to signaling and transcriptional adaptations required for the emergence of a fully activated CAF phenotype. These findings uncover a novel role for the BORG/septin network in cancer. Here, we demonstrate that Cdc42EP3 function in CAFs relies on tight regulation by Cdc42. PMID:27248291

  9. 2. Historic American Buildings Survey, E.P. MacFarland, Photographer May 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, E.P. MacFarland, Photographer May 10, 1934, DETAIL OF PORTICO (FROM SOUTHWEST). - Old Leake & Watts Orphanage, Amsterdam Avenue & 110th Street, New York County, NY

  10. Report On The Commissioning Of The JET-EP ITER-Like ICRH Antenna

    SciTech Connect

    Durodie, F.; Dumortier, P.; Huygen, S.; Lamalle, P. U.; Messiaen, A. M.; Vervier, M.; Vrancken, M.; Argouarch, A.

    2007-09-28

    The paper summarizes the activities carried out and difficulties encountered assembling and testing the JET-EP ITER-like ICRH antenna. First results from low power as well as high power testing and commissioning activities are presented.

  11. Science, technology, power and sex: PrEP and HIV-positive gay men in Paris.

    PubMed

    Brisson, Julien; Nguyen, Vinh-Kim

    2017-02-21

    The pre-exposure prophylaxis (PrEP) drug Truvada is a new HIV prevention technology that is predominantly promoted as relevant to HIV-negative gay men. This paper explores what PrEP represents for HIV-positive gay men living in Paris, based upon data collected through interviews and ethnographic research. While HIV-positive gay men do not directly consume Truvada through PrEP, they nonetheless hold opinions and understandings of this drug, specifically as it relates to their own sexuality. This paper expands the representations and meanings of this new technology in a different light through the voices of gay men living with HIV in Paris. The main argument of this article is that PrEP as an additional HIV prevention tool blurs the lines between science, technologies and human sexuality.

  12. 30 CFR 250.227 - What environmental impact analysis (EIA) information must accompany the EP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... accompany your EP: (a) General requirements. Your EIA must: (1) Assess the potential environmental impacts... use, subsistence resources and harvest practices, recreation, recreational and commercial fishing... Supervisor. (c) Environmental impacts. Your EIA must: (1) Analyze the potential direct and indirect...

  13. Scattering from binary optics

    NASA Technical Reports Server (NTRS)

    Ricks, Douglas W.

    1993-01-01

    There are a number of sources of scattering in binary optics: etch depth errors, line edge errors, quantization errors, roughness, and the binary approximation to the ideal surface. These sources of scattering can be systematic (deterministic) or random. In this paper, scattering formulas for both systematic and random errors are derived using Fourier optics. These formulas can be used to explain the results of scattering measurements and computer simulations.

  14. Prostanoid EP1- and TP-receptors involved in the contraction of human pulmonary veins

    PubMed Central

    Walch, Laurence; de Montpreville, Vincent; Brink, Charles; Norel, Xavier

    2001-01-01

    To characterize the prostanoid receptors (TP, FP, EP1 and/or EP3) involved in the vasoconstriction of human pulmonary veins, isolated venous preparations were challenged with different prostanoid-receptor agonists in the absence or presence of selective antagonists. The stable thromboxane A2 mimetic, U46619, was a potent constrictor agonist on human pulmonary veins (pEC50=8.60±0.11 and Emax=4.61±0.46 g; n=15). The affinity values for two selective TP-antagonists (BAY u3405 and GR32191B) versus U46619 were BAY u3405: pA2=8.94±0.23 (n=3) and GR32191B: apparent pKB=8.25±0.34 (n=3), respectively. These results are consistent with the involvement of TP-receptor in the U46619 induced contractions. The two EP1-/EP3- agonists (17-phenyl-PGE2 and sulprostone) induced contraction of human pumonary veins (pEC50=8.56±0.18; Emax=0.56±0.24 g; n=5 and pEC50=7.65±0.13; Emax=1.10±0.12 g; n=14, respectively). The potency ranking for these agonists: 17-phenyl-PGE2>sulprostone suggests the involvement of an EP1-receptor rather than EP3. In addition, the contractions induced by sulprostone, 17-phenyl-PGE2 and the IP-/EP1- agonist (iloprost) were blocked by the DP-/EP1-/EP2-receptor antagonist (AH6809) as well as by the EP1 antagonist (SC19220). PGF2α induced small contractions which were blocked by AH6809 while fluprostenol was ineffective. These results indicate that FP-receptors are not implicated in the contraction of human pulmonary veins. These data suggest that the contractions induced by prostanoids involved TP- and EP1-receptors in human pulmonary venous smooth muscle. PMID:11739243

  15. Social, structural, behavioral and clinical factors influencing retention in Pre-Exposure Prophylaxis (PrEP) care in Mississippi

    PubMed Central

    Arnold, Trisha; Brinkley-Rubinstein, Lauren; Chan, Philip A.; Perez-Brumer, Amaya; Bologna, Estefany S.; Beauchamps, Laura; Johnson, Kendra; Mena, Leandro; Nunn, Amy

    2017-01-01

    Pre-exposure prophylaxis (PrEP) is a biomedical intervention that can reduce rates of HIV transmission when taken once daily by HIV-negative individuals. Little is understood about PrEP uptake and retention in care among the populations most heavily impacted by the HIV epidemic, particularly among young men who have sex with men (YMSM) in the Deep South. Therefore, this study explored the structural, social, behavioral, and clinical factors that affect PrEP use and retention in care among YMSM in Jackson, Mississippi. Thirty MSM who were prescribed PrEP at an outpatient primary care clinic were interviewed and included 23 men who had been retained in PrEP care and seven who had not been retained. The mean age of participants was 26.6 years. Most (23) participants were African American. Major factors affecting PrEP use and retention in PrEP care included 1) structural factors such as cost and access to financial assistance for medications and clinical services; 2) social factors such as stigma and relationship status; 3) behavioral factors including sexual risk behaviors; and 4) clinical factors such as perceived and actual side effects. Many participants also discussed the positive spillover effects of PrEP use and reported that PrEP had a positive impact on their health. Four of the seven individuals who had not been retained re-enrolled in PrEP care after completing their interviews, suggesting that case management and ongoing outreach can enhance retention in PrEP care. Interventions to enhance retention in PrEP care among MSM in the Deep South will be most effective if they address the complex structural, social, clinical, and behavioral factors that influence PrEP uptake and retention in PrEP care. PMID:28222118

  16. Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.

    PubMed

    Jiang, Jianxiong; Dingledine, Ray

    2013-07-01

    Modulation of a specific prostanoid synthase or receptor provides therapeutic alternatives to nonsteroidal anti-inflammatory drugs (NSAIDs) for treating pathological conditions governed by cyclooxygenase-2 (COX-2 or PTGS2). Among the COX-2 downstream signaling pathways, the prostaglandin E2 (PGE2) receptor EP2 subtype (PTGER2) is emerging as a crucial mediator of many physiological and pathological events. Genetic ablation strategies and recent advances in chemical biology provide tools for a better understanding of EP2 signaling. In the brain, the EP2 receptor modulates some beneficial effects, including neuroprotection, in acute models of excitotoxicity, neuroplasticity, and spatial learning via cAMP-PKA signaling. Conversely, EP2 activation accentuates chronic inflammation mainly through the cAMP-Epac pathway, likely contributing to delayed neurotoxicity. EP2 receptor activation also engages β-arrestin in a G-protein-independent pathway that promotes tumor cell growth and migration. Understanding the conditions under which multiple EP2 signaling pathways are engaged might suggest novel therapeutic strategies to target this key inflammatory prostaglandin receptor.

  17. Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

    PubMed Central

    and, Jianxiong Jiang; Dingledine, Ray

    2014-01-01

    Modulation of a specific prostanoid synthase or receptor provides therapeutic alternatives to non-steroidal anti-inflammatory drugs (NSAIDs) for treating cyclooxygenase-2 (COX-2 or PTGS2)-governed pathological conditions. Among the COX-2 downstream signaling pathways, the prostaglandin E2 (PGE2) receptor EP2 subtype (PTGER2) is emerging as a crucial mediator of many physiological and pathological events. Genetic ablation strategies and recent advances in chemical biology provide tools for a better understanding of EP2 signaling. In the brain, the EP2 receptor modulates some beneficial effects including neuroprotection in acute models of excitotoxicity, neuroplasticity, and spatial learning via cAMP/PKA signaling. Conversely, EP2 activation accentuates chronic inflammation mainly through the cAMP/Epac pathway, likely contributing to delayed neurotoxicity. EP2 receptor activation also engages β-arrestin in a G protein-independent pathway that promotes tumor cell growth and migration. Understanding the conditions under which multiple EP2 signaling pathways are engaged might suggest novel therapeutic strategies targeting this key inflammatory prostaglandin receptor. PMID:23796953

  18. Component analysis and heavy metal adsorption ability of extracellular polymeric substances (EPS) from sulfate reducing bacteria.

    PubMed

    Yue, Zheng-Bo; Li, Qing; Li, Chuan-chuan; Chen, Tian-hu; Wang, Jin

    2015-10-01

    Extracellular polymeric substances (EPS) play an important role in the treatment of acid mine drainage (AMD) by sulfate-reducing bacteria (SRB). In this paper, Desulfovibrio desulfuricans was used as the test strain to explore the effect of heavy metals on the components and adsorption ability of EPS. Fourier-transform infrared (FTIR) spectroscopy analysis results showed that heavy metals did not influence the type of functional groups of EPS. Potentiometric titration results indicated that the acidic constants (pKa) of the EPS fell into three ranges of 3.5-4.0, 5.9-6.7, and 8.9-9.8. The adsorption site concentrations of the surface functional groups also increased. Adsorption results suggested that EPS had a specific binding affinity for the dosed heavy metal, and that EPS extracted from the Zn(2+)-dosed system had a higher binding affinity for all heavy metals. Additionally, Zn(2+) decreased the inhibitory effects of Cd(2+) and Cu(2+) on the SRB.

  19. Brief Report: PrEP Uptake, Adherence, and Discontinuation Among California YMSM Using Geosocial Networking Applications.

    PubMed

    Holloway, Ian W; Dougherty, Ryan; Gildner, Jennifer; Beougher, Sean C; Pulsipher, Craig; Montoya, Jorge A; Plant, Aaron; Leibowitz, Arleen

    2017-01-01

    We investigated pre-exposure prophylaxis (PrEP) uptake, adherence, and discontinuation among young app-using men who have sex with men in California (N = 761). Approximately, 9.7% of participants had ever used PrEP; 87% of those deemed good candidates for screening (indicated by a Centers for Disease Control and Prevention risk index score ≥10) were not current or past users. PrEP use was associated with higher income [adjusted odds ratio (aOR): 4.13; confidence interval (CI): 1.87 to 9.12], receptive condomless anal sex (aOR: 3.41; CI: 1.71 to 6.78), HIV-positive sex partners (aOR: 2.87; CI: 1.53 to 5.38), popper use (aOR: 3.47; CI: 1.96 to 6.13), and recent sexually transmitted infection diagnosis (aOR: 2.90; CI: 1.64 to 5.13). Some users (41.5%) wanted help remembering to take PrEP. The top reason for discontinuation was concern about long-term side effects (33.0%). Young men who have sex with men app users are prime candidates for PrEP, despite low uptake. Apps may be useful tools for PrEP information dissemination, adherence monitoring, and support.

  20. A novel integrated approach to quantitatively evaluate the efficiency of extracellular polymeric substances (EPS) extraction process.

    PubMed

    Sun, Min; Li, Wen-Wei; Yu, Han-Qing; Harada, Hideki

    2012-12-01

    A novel integrated approach is developed to quantitatively evaluate the extracellular polymeric substances (EPS) extraction efficiency after taking into account EPS yield, EPS damage, and cell lysis. This approach incorporates grey relational analysis and fuzzy logic analysis, in which the evaluation procedure is established on the basis of grey relational coefficients generation, membership functions construction, and fuzzy rules description. The flocculation activity and DNA content of EPS are chosen as the two evaluation responses. To verify the feasibility and effectiveness of this integrated approach, EPS from Bacillus megaterium TF10 are extracted using five different extraction methods, and their extraction efficiencies are evaluated as one real case study. Based on the evaluation results, the maximal extraction grades and corresponding optimal extraction times of the five extraction methods are ordered as EDTA, 10 h > formaldehyde + NaOH, 60 min > heating, 120 min > ultrasonication, 30 min > H₂SO₄, 30 min > control. The proposed approach here offers an effective tool to select appropriate EPS extraction methods and determine the optimal extraction conditions.

  1. EpCAM Expression in Lymph Node and Bone Metastases of Prostate Carcinoma: A Pilot Study

    PubMed Central

    Campos, Anna K.; Hoving, Hilde D.; Rosati, Stefano; van Leenders, Geert J. L. H.; de Jong, Igle J.

    2016-01-01

    There is an urgent need for new imaging modalities in prostate carcinoma staging. A non-invasive modality that can assess lymph node and bone metastases simultaneously is preferred. Epithelial cell adhesion molecule (EpCAM) is a membranous protein of interest as an imaging target since it is overexpressed in prostatic carcinoma compared with benign prostate epithelium and compared with stroma. However, EpCAM expression in lymph node metastases is sparsely available in the literature and EpCAM expression in bone metastases is yet unknown. The current study evaluates the expression of EpCAM in prostate carcinoma lymph nodes, in matched normal lymph nodes, in prostate carcinoma bone metastases, and in normal bone by immunohistochemistry. EpCAM was expressed in 100% of lymph node metastases (21 out of 21), in 0% of normal lymph nodes (0 out of 21), in 95% of bone metastases (19 out of 20), and in 0% of normal bone (0 out of 14). Based on these results, EpCAM may be a feasible imaging target in prostate carcinoma lymph node and bone metastases. Prospective clinical trials are needed to confirm current results. Preoperative visualization of prostate carcinoma metastases will improve disease staging and will prevent unnecessary invasive surgery. PMID:27690012

  2. Characterization of Pressure Transients Generated by Nanosecond Electrical Pulse (nsEP) Exposure.

    PubMed

    Roth, Caleb C; Barnes, Ronald A; Ibey, Bennett L; Beier, Hope T; Christopher Mimun, L; Maswadi, Saher M; Shadaram, Mehdi; Glickman, Randolph D

    2015-10-09

    The mechanism(s) responsible for the breakdown (nanoporation) of cell plasma membranes after nanosecond pulse (nsEP) exposure remains poorly understood. Current theories focus exclusively on the electrical field, citing electrostriction, water dipole alignment and/or electrodeformation as the primary mechanisms for pore formation. However, the delivery of a high-voltage nsEP to cells by tungsten electrodes creates a multitude of biophysical phenomena, including electrohydraulic cavitation, electrochemical interactions, thermoelastic expansion, and others. To date, very limited research has investigated non-electric phenomena occurring during nsEP exposures and their potential effect on cell nanoporation. Of primary interest is the production of acoustic shock waves during nsEP exposure, as it is known that acoustic shock waves can cause membrane poration (sonoporation). Based on these observations, our group characterized the acoustic pressure transients generated by nsEP and determined if such transients played any role in nanoporation. In this paper, we show that nsEP exposures, equivalent to those used in cellular studies, are capable of generating high-frequency (2.5 MHz), high-intensity (>13 kPa) pressure transients. Using confocal microscopy to measure cell uptake of YO-PRO®-1 (indicator of nanoporation of the plasma membrane) and changing the electrode geometry, we determined that acoustic waves alone are not responsible for poration of the membrane.

  3. Functional consequences of EpCam mutation in mice and men.

    PubMed

    Mueller, James L; McGeough, Matthew D; Peña, Carla A; Sivagnanam, Mamata

    2014-02-15

    Congenital tufting enteropathy (CTE) is a severe diarrheal disease of infancy characterized by villous changes and epithelial tufts. We previously identified mutations in epithelial cell adhesion molecule (EpCAM) as the cause of CTE. We developed an in vivo mouse model of CTE based on EpCAM mutations found in patients with the aim to further elucidate the in vivo role of EpCAM and allow for a direct comparison to human CTE. Using Cre-LoxP recombination technology, we generated a construct lacking exon 4 in Epcam. Epcam(Δ4/Δ4) mice and CTE patient intestinal tissue integrity was analyzed by histology using both light immunohistochemistry and electron microscopy. Epcam(Δ4/Δ4) mice demonstrate neonatal lethality and growth retardation with pathological features, including epithelial tufts, enterocyte crowding, altered desmosomes, and intercellular gaps, similar to human CTE patients. Mutant EpCAM protein is present at low levels and is mislocalized in the intestine of Epcam(Δ4/Δ4) mice and CTE patients. Deletion of exon 4 was found to decrease expression of both EpCAM and claudin-7 causing a loss of colocalization, functionally disrupting the EpCAM/claudin-7 complex, a finding for the first time confirmed in CTE patients. Furthermore, compared with unaffected mice, mutation of Epcam leads to enhanced permeability and intestinal cell migration, uncovering underlying disease mechanisms.

  4. Characterization of Pressure Transients Generated by Nanosecond Electrical Pulse (nsEP) Exposure

    NASA Astrophysics Data System (ADS)

    Roth, Caleb C.; Barnes, Ronald A., Jr.; Ibey, Bennett L.; Beier, Hope T.; Christopher Mimun, L.; Maswadi, Saher M.; Shadaram, Mehdi; Glickman, Randolph D.

    2015-10-01

    The mechanism(s) responsible for the breakdown (nanoporation) of cell plasma membranes after nanosecond pulse (nsEP) exposure remains poorly understood. Current theories focus exclusively on the electrical field, citing electrostriction, water dipole alignment and/or electrodeformation as the primary mechanisms for pore formation. However, the delivery of a high-voltage nsEP to cells by tungsten electrodes creates a multitude of biophysical phenomena, including electrohydraulic cavitation, electrochemical interactions, thermoelastic expansion, and others. To date, very limited research has investigated non-electric phenomena occurring during nsEP exposures and their potential effect on cell nanoporation. Of primary interest is the production of acoustic shock waves during nsEP exposure, as it is known that acoustic shock waves can cause membrane poration (sonoporation). Based on these observations, our group characterized the acoustic pressure transients generated by nsEP and determined if such transients played any role in nanoporation. In this paper, we show that nsEP exposures, equivalent to those used in cellular studies, are capable of generating high-frequency (2.5 MHz), high-intensity (>13 kPa) pressure transients. Using confocal microscopy to measure cell uptake of YO-PRO®-1 (indicator of nanoporation of the plasma membrane) and changing the electrode geometry, we determined that acoustic waves alone are not responsible for poration of the membrane.

  5. Characterization of Pressure Transients Generated by Nanosecond Electrical Pulse (nsEP) Exposure

    PubMed Central

    Roth, Caleb C.; Barnes Jr., Ronald A.; Ibey, Bennett L.; Beier, Hope T.; Christopher Mimun, L.; Maswadi, Saher M.; Shadaram, Mehdi; Glickman, Randolph D.

    2015-01-01

    The mechanism(s) responsible for the breakdown (nanoporation) of cell plasma membranes after nanosecond pulse (nsEP) exposure remains poorly understood. Current theories focus exclusively on the electrical field, citing electrostriction, water dipole alignment and/or electrodeformation as the primary mechanisms for pore formation. However, the delivery of a high-voltage nsEP to cells by tungsten electrodes creates a multitude of biophysical phenomena, including electrohydraulic cavitation, electrochemical interactions, thermoelastic expansion, and others. To date, very limited research has investigated non-electric phenomena occurring during nsEP exposures and their potential effect on cell nanoporation. Of primary interest is the production of acoustic shock waves during nsEP exposure, as it is known that acoustic shock waves can cause membrane poration (sonoporation). Based on these observations, our group characterized the acoustic pressure transients generated by nsEP and determined if such transients played any role in nanoporation. In this paper, we show that nsEP exposures, equivalent to those used in cellular studies, are capable of generating high-frequency (2.5 MHz), high-intensity (>13 kPa) pressure transients. Using confocal microscopy to measure cell uptake of YO-PRO®-1 (indicator of nanoporation of the plasma membrane) and changing the electrode geometry, we determined that acoustic waves alone are not responsible for poration of the membrane. PMID:26450165

  6. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors.

    PubMed

    Tunaru, Sorin; Althoff, Till F; Nüsing, Rolf M; Diener, Martin; Offermanns, Stefan

    2012-06-05

    Castor oil is one of the oldest drugs. When given orally, it has a laxative effect and induces labor in pregnant females. The effects of castor oil are mediated by ricinoleic acid, a hydroxylated fatty acid released from castor oil by intestinal lipases. Despite the wide-spread use of castor oil in conventional and folk medicine, the molecular mechanism by which ricinoleic acid acts remains unknown. Here we show that the EP(3) prostanoid receptor is specifically activated by ricinoleic acid and that it mediates the pharmacological effects of castor oil. In mice lacking EP(3) receptors, the laxative effect and the uterus contraction induced via ricinoleic acid are absent. Although a conditional deletion of the EP(3) receptor gene in intestinal epithelial cells did not affect castor oil-induced diarrhea, mice lacking EP(3) receptors only in smooth-muscle cells were unresponsive to this drug. Thus, the castor oil metabolite ricinoleic acid activates intestinal and uterine smooth-muscle cells via EP(3) prostanoid receptors. These findings identify the cellular and molecular mechanism underlying the pharmacological effects of castor oil and indicate a role of the EP(3) receptor as a target to induce laxative effects.

  7. Functional consequences of EpCam mutation in mice and men

    PubMed Central

    Mueller, James L.; McGeough, Matthew D.; Peña, Carla A.

    2013-01-01

    Congenital tufting enteropathy (CTE) is a severe diarrheal disease of infancy characterized by villous changes and epithelial tufts. We previously identified mutations in epithelial cell adhesion molecule (EpCAM) as the cause of CTE. We developed an in vivo mouse model of CTE based on EpCAM mutations found in patients with the aim to further elucidate the in vivo role of EpCAM and allow for a direct comparison to human CTE. Using Cre-LoxP recombination technology, we generated a construct lacking exon 4 in Epcam. EpcamΔ4/Δ4 mice and CTE patient intestinal tissue integrity was analyzed by histology using both light immunohistochemistry and electron microscopy. EpcamΔ4/Δ4 mice demonstrate neonatal lethality and growth retardation with pathological features, including epithelial tufts, enterocyte crowding, altered desmosomes, and intercellular gaps, similar to human CTE patients. Mutant EpCAM protein is present at low levels and is mislocalized in the intestine of EpcamΔ4/Δ4 mice and CTE patients. Deletion of exon 4 was found to decrease expression of both EpCAM and claudin-7 causing a loss of colocalization, functionally disrupting the EpCAM/claudin-7 complex, a finding for the first time confirmed in CTE patients. Furthermore, compared with unaffected mice, mutation of Epcam leads to enhanced permeability and intestinal cell migration, uncovering underlying disease mechanisms. PMID:24337010

  8. Expression of Prostanoid EP3 Receptors in Oral Squamous Epithelium and Oral Squamous Cell Carcinoma

    PubMed Central

    Ishfaq, Muhammad; Nagi, A. H.

    2015-01-01

    Objectives. To carry out a descriptive analysis of the expression of the EP3 receptors of PGE2 in different histological grades of OSCC and adjacent normal epithelium. Material and Methods. A total of 46 patients presenting with various histological subtypes and grades of OSCC were recruited from Maxillofacial Surgery Department of Nishtar Institute of Dentistry Multan. Microscopically tumour subtyping and histological grading according to Anneroth's grading system were carried out. Immunohistochemical staining with rabbit polyclonal EP3 receptor antibody was performed and sections were scored for intensity and proportion of positive adjacent squamous epithelial and tumour cells. Results. Out of 46 patients n = 28 (60.9%) were well differentiated, n = 15 (32.6%) were moderately differentiated, and only n = 3 (6.5%) were poorly differentiated. All n = 46 cases of OSCC were positive for EP3 receptor antibody, n = 14 (30.4%) cases had strong intensity of anti EP3 antibody staining in tumour tissue, n = 17 (37%) cases showed moderate intensity, and n = 15 (32.6%) cases showed weak intensity. Conclusion. Prostanoid EP3 receptors are widely but variably expressed in OSCC. Most of well differentiated OSCC cases show a moderate to strong expression of EP3 receptors. However, insignificant statistical relation to histological grades of OSCC has been observed. This might be due to small sample size of the study. PMID:25741449

  9. Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

    PubMed Central

    Jiang, Jianxiong; Ganesh, Thota; Du, Yuhong; Thepchatri, Pahk; Rojas, Asheebo; Lewis, Iestyn; Kurtkaya, Serdar; Li, Lian; Qui, Min; Serrano, Geidy; Shaw, Renee; Sun, Aiming; Dingledine, Ray

    2010-01-01

    Activation of the Gαs-coupled EP2 receptor for prostaglandin E2 (PGE2) promotes cell survival in several models of tissue damage. To advance understanding of EP2 functions, we designed experiments to develop allosteric potentiators of this key prostaglandin receptor. Screens of 292,000 compounds identified 93 that at 20 μM (i) potentiated the cAMP response to a low concentration of PGE2 by > 50%; (ii) had no effect on EP4 or β2 adrenergic receptors, the cAMP assay itself, or the parent cell line; and (iii) increased the potency of PGE2 on EP2 receptors at least 3-fold. In aqueous solution, the active compounds are largely present as nanoparticles that appear to serve as active reservoirs for bioactive monomer. From 94 compounds synthesized or purchased, based on the modification of one hit compound, the most active increased the potency of PGE2 on EP2 receptors 4- to 5-fold at 10 to 20 μM and showed substantial neuroprotection in an excitotoxicity model. These small molecules represent previously undescribed allosteric modulators of a PGE2 receptor. Our results strongly reinforce the notion that activation of EP2 receptors by endogenous PGE2 released in a cell-injury setting is neuroprotective. PMID:20080612

  10. Multiple scattering technique lidar

    NASA Technical Reports Server (NTRS)

    Bissonnette, Luc R.

    1992-01-01

    The Bernouilli-Ricatti equation is based on the single scattering description of the lidar backscatter return. In practice, especially in low visibility conditions, the effects of multiple scattering can be significant. Instead of considering these multiple scattering effects as a nuisance, we propose here to use them to help resolve the problems of having to assume a backscatter-to-extinction relation and specifying a boundary value for a position far remote from the lidar station. To this end, we have built a four-field-of-view lidar receiver to measure the multiple scattering contributions. The system has been described in a number of publications that also discuss preliminary results illustrating the multiple scattering effects for various environmental conditions. Reported here are recent advances made in the development of a method of inverting the multiple scattering data for the determination of the aerosol scattering coefficient.

  11. Production of cryoprotectant extracellular polysaccharide substances (EPS) by the marine psychrophilic bacterium Colwellia psychrerythraea strain 34H under extreme conditions.

    PubMed

    Marx, Joseph G; Carpenter, Shelly D; Deming, Jody W

    2009-01-01

    Extracellular polysaccharide substances (EPS) play critical roles in microbial ecology, including the colonization of extreme environments in the ocean, from sea ice to the deep sea. After first developing a sugar-free growth medium, we examined the relative effects of temperature, pressure, and salinity on EPS production (on a per cell basis) by the obligately marine and psychrophilic gamma-proteobacterium, Colwellia psychrerythraea strain 34H. Over growth-permissive temperatures of approximately 10 to -4 degrees C, EPS production did not change, but from -8 to -14 degrees C when samples froze, EPS production rose dramatically. Similarly, at growth-permissive hydrostatic pressures of 1-200 atm (1 atm = 101.325 kPa) (at -1 and 8 degrees C), EPS production was unchanged, but at higher pressures of 400 and 600 atm EPS production rose markedly. In salinity tests at 10-100 parts per million (and -1 and 5 degrees C), EPS production increased at the freshest salinity tested. Extreme environmental conditions thus appear to stimulate EPS production by this strain. Furthermore, strain 34H recovered best from deep-freezing to -80 degrees C (not found for Earthly environments) if first supplemented with a preparation of its own EPS, rather than other cryoprotectants like glycerol, suggesting EPS production as both a survival strategy and source of compounds with potentially novel properties for biotechnological and other applications.

  12. Pre-exposure Prophylaxis (PrEP) for HIV Infection: How Antiretroviral Pharmacology helps to Monitor and Improve Adherence

    PubMed Central

    Blumenthal, Jill; Haubrich, Richard

    2014-01-01

    Pre-exposure prophylaxis (PrEP) with antiretroviral drugs is a novel biomedical intervention that can prevent HIV transmission among high-risk populations. As findings from multiple PrEP studies have suggested that adherence is vital to achieve the full prevention benefits of PrEP, it is important to understand the clinical pharmacology and pharmacokinetic (PK) properties of PrEP antiretrovirals, the association of PK and PrEP efficacy and the potential for drug concentration measurement to be used as a tool to monitor PrEP adherence. In this review, we examine studies related to PrEP adherence with attention to the clinical pharmacology and pharmacokinetics of current and novel PrEP agents. Studies of animal models, pharmacokinetics and clinical trials related to PrEP and adherence were reviewed. In summary, when combined as part of a comprehensive prevention strategy that includes use of condoms and risk reduction counseling, PrEP has tremendous promise as a adjunctive biomedical HIV prevention intervention, providing that adherence is maintained. PMID:23800167

  13. Role of Microbial Exopolymeric Substances (EPS) on Chromium Sorption and Transport in Heterogeneous Subsurface Soils: I. Cr(III) Complexation with EPS in Aqueous Solution

    SciTech Connect

    C Kantar; H Demiray; N Dogan; C Dodge

    2011-12-31

    Chromium (III) binding by exopolymeric substances (EPS) isolated from Pseudomonas putida P18, Pseudomonas aeruginosa P16 and Pseudomonas stutzeri P40 strains were investigated by the determination of conditional stability constants and the concentration of functional groups using the ion-exchange experiments and potentiometric titrations. Spectroscopic (EXAFS) analysis was also used to obtain information on the nature of Cr(III) binding with EPS functional groups. The data from ion-exchange experiments and potentiometric titrations were evaluated using a non-electrostatic discrete ligand approach. The modeling results show that the acid/base properties of EPSs can be best characterized by invoking four different types of acid functional groups with arbitrarily assigned pK{sub a} values of 4, 6, 8 and 10. The analysis of ion-exchange data using the discrete ligand approach suggests that while the Cr binding by EPS from P. aeruginosa can be successfully described based on a reaction stoichiometry of 1:2 between Cr(III) and HL{sub 2} monoprotic ligands, the accurate description of Cr binding by EPSs extracted from P. putida and P. stutzeri requires postulation of 1:1 Cr(III)-ligand complexes with HL{sub 2} and HL{sub 3} monoprotic ligands, respectively. These results indicate that the carboxyl and/or phosphoric acid sites contribute to Cr(III) binding by microbial EPS, as also confirmed by EXAFS analysis performed in the current study. Overall, this study highlights the need for incorporation of Cr-EPS interactions into transport and speciation models to more accurately assess microbial Cr(VI) reduction and chromium transport in subsurface systems, including microbial reactive treatment barriers.

  14. Role of microbial exopolymeric substances (EPS) on chromium sorption and transport in heterogeneous subsurface soils: I. Cr(III) complexation with EPS in aqueous solution

    SciTech Connect

    Kantar, C.; Dodge, C.; Demiray, H.; Dogan, N.M.

    2011-01-26

    Chromium (III) binding by exopolymeric substances (EPS) isolated from Pseudomonas putida P18, Pseudomonas aeruginosa P16 and Pseudomonas stutzeri P40 strains were investigated by the determination of conditional stability constants and the concentration of functional groups using the ion-exchange experiments and potentiometric titrations. Spectroscopic (EXAFS) analysis was also used to obtain information on the nature of Cr(III) binding with EPS functional groups. The data from ion-exchange experiments and potentiometric titrations were evaluated using a non-electrostatic discrete ligand approach. The modeling results show that the acid/base properties of EPSs can be best characterized by invoking four different types of acid functional groups with arbitrarily assigned pK{sub a} values of 4, 6, 8 and 10. The analysis of ion-exchange data using the discrete ligand approach suggests that while the Cr binding by EPS from P. aeruginosa can be successfully described based on a reaction stoichiometry of 1:2 between Cr(III) and HL{sub 2} monoprotic ligands, the accurate description of Cr binding by EPSs extracted from P. putida and P. stutzeri requires postulation of 1:1 Cr(III)-ligand complexes with HL{sub 2} and HL{sub 3} monoprotic ligands, respectively. These results indicate that the carboxyl and/or phosphoric acid sites contribute to Cr(III) binding by microbial EPS, as also confirmed by EXAFS analysis performed in the current study. Overall, this study highlights the need for incorporation of Cr-EPS interactions into transport and speciation models to more accurately assess microbial Cr(VI) reduction and chromium transport in subsurface systems, including microbial reactive treatment barriers.

  15. Role of microbial exopolymeric substances (EPS) on chromium sorption and transport in heterogeneous subsurface soils: I. Cr(III) complexation with EPS in aqueous solution.

    PubMed

    Kantar, Cetin; Demiray, Hilal; Dogan, Nazime Mercan; Dodge, Cleveland J

    2011-03-01

    Chromium (III) binding by exopolymeric substances (EPS) isolated from Pseudomonas putida P18, Pseudomonas aeruginosa P16 and Pseudomonas stutzeri P40 strains were investigated by the determination of conditional stability constants and the concentration of functional groups using the ion-exchange experiments and potentiometric titrations. Spectroscopic (EXAFS) analysis was also used to obtain information on the nature of Cr(III) binding with EPS functional groups. The data from ion-exchange experiments and potentiometric titrations were evaluated using a non-electrostatic discrete ligand approach. The modeling results show that the acid/base properties of EPSs can be best characterized by invoking four different types of acid functional groups with arbitrarily assigned pK(a) values of 4, 6, 8 and 10. The analysis of ion-exchange data using the discrete ligand approach suggests that while the Cr binding by EPS from P. aeruginosa can be successfully described based on a reaction stoichiometry of 1:2 between Cr(III) and HL(2) monoprotic ligands, the accurate description of Cr binding by EPSs extracted from P. putida and P. stutzeri requires postulation of 1:1 Cr(III)-ligand complexes with HL(2) and HL(3) monoprotic ligands, respectively. These results indicate that the carboxyl and/or phosphoric acid sites contribute to Cr(III) binding by microbial EPS, as also confirmed by EXAFS analysis performed in the current study. Overall, this study highlights the need for incorporation of Cr-EPS interactions into transport and speciation models to more accurately assess microbial Cr(VI) reduction and chromium transport in subsurface systems, including microbial reactive treatment barriers.

  16. Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skin.

    PubMed

    Ansari, Kausar M; Sung, You Me; He, Guobin; Fischer, Susan M

    2007-10-01

    The EP2 prostanoid receptor is one of the four subtypes of receptors for prostaglandin E2 (PGE2). We previously reported that deletion of EP2 led to resistance to chemically induced mouse skin carcinogenesis, whereas overexpression of EP2 resulted in enhanced tumor development. The purpose of this study was to investigate the underlying molecular mechanisms. We found that EP2 knockout mice had reduced cyclooxygenase-2 (COX-2) expression after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment compared with wild-type (WT) mice. Further, primary keratinocytes from EP2 transgenic mice had increased COX-2 expression after either TPA or PGE2 treatment and COX-2 expression was blocked by 10 microM SQ 22,536, an adenylate cyclase inhibitor. EP2 knockout mice had significantly decreased, whereas EP2 transgenic mice had significantly increased PGE2 production in response to a single treatment of TPA. Cyclic AMP response element-binding protein (CREB) phosphorylation was elevated to a greater extent in keratinocytes from EP2 transgenic mice compared with those of WT mice following PGE2 treatment. A protein kinase A (PKA) inhibitor reduced PGE2-mediated CREB phosphorylation in keratinocytes from EP2 transgenic mice. Furthermore, we found that there was no CREB phosphorylation in EP2 knockout mice following PGE2 treatment. PGE2-induced DNA synthesis (cell proliferation) was significantly decreased in keratinocytes from EP2 knockout mice following pretreatment with 10 microM SQ 22,536. Taken together, EP2 activation of the PKA/CREB-signaling pathway is responsible for keratinocyte proliferation and our findings reveal a positive feedback loop between COX-2 and PGE2 that is mediated by the EP2 receptor.

  17. Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts

    PubMed Central

    Gao, Min; Cao, Rong; Du, Shengnan; Jia, Xiao; Zheng, Senfeng; Huang, Shizheng; Han, Qifei; Liu, Jia; Zhang, Xiaoyan; Miao, Yifei; Kang, Jihong; Gustafsson, Jan-Åke; Guan, Youfei

    2015-01-01

    The antidiuretic hormone arginine vasopressin is a systemic effector in urinary concentration. However, increasing evidence suggests that other locally produced factors may also play an important role in the regulation of water reabsorption in renal collecting ducts. Recently, prostaglandin E2 (PGE2) receptor EP4 has emerged as a potential therapeutic target for the treatment of nephrogenic diabetes insipidus, but the underlying mechanism is unknown. To evaluate the role of EP4 in regulating water homeostasis, mice with renal tubule-specific knockout of EP4 (Ksp-EP4−/−) and collecting duct-specific knockout of EP4 (AQP2-EP4−/−) were generated using the Cre-loxP recombination system. Urine concentrating defect was observed in both Ksp-EP4−/− and AQP2-EP4−/− mice. Decreased aquaporin 2 (AQP2) abundance and apical membrane targeting in renal collecting ducts were evident in Ksp-EP4−/− mice. In vitro studies demonstrated that AQP2 mRNA and protein levels were significantly up-regulated in mouse primary inner medullary collecting duct (IMCD) cells after pharmacological activation or adenovirus-mediated overexpression of EP4 in a cAMP/cAMP-response element binding protein-dependent manner. In addition, EP4 activation or overexpression also increased AQP2 membrane accumulation in a mouse IMCD cell line (IMCD3) stably transfected with the AQP2 gene, mainly through the cAMP/protein kinase A and extracellular signal-regulated kinase pathways. In summary, the EP4 receptor in renal collecting ducts plays an important role in regulating urinary concentration under physiological conditions. The ability of EP4 to promote AQP2 membrane targeting and increase AQP2 abundance makes it a potential therapeutic target for the treatment of clinical disorders including acquired and congenital diabetes insipidus. PMID:26100911

  18. Imaging the proton via hard exclusive production in diffractive pp scattering

    SciTech Connect

    Charles Hyde; Leonid Frankfurt; Mark Strikman; Christian Weiss

    2007-05-21

    We discuss the prospects for probing Generalized Parton Distributions (GPDs) via exclusive production of a high-mass system (H = heavy quarkonium, di-photon, di-jet, Higgs boson) in diffractive pp scattering, pp -> p + H + p. In such processes the interplay of hard and soft interactions gives rise to a diffraction pattern in the final-state proton transverse momenta, which is sensitive to the transverse spatial distribution of partons in the colliding protons. We comment on the plans for diffractive pp measurements at RHIC and LHC. Such studies could complement future measurements of GPDs in hard exclusive ep scattering (JLab, COMPASS, EIC).

  19. Correlation of EPS content in activated sludge at different sludge retention times with membrane fouling phenomena.

    PubMed

    Al-Halbouni, Djamila; Traber, Jacqueline; Lyko, Sven; Wintgens, Thomas; Melin, Thomas; Tacke, Daniela; Janot, Andreas; Dott, Wolfgang; Hollender, Juliane

    2008-03-01

    In this study, activated sludge characteristics were studied with regard to membrane fouling in membrane bioreactors (MBRs) for two pilot plants and one full-scale plant treating municipal wastewater. For the full-scale MBR, concentrations of extracellular polymeric substances (EPS) bound to sludge flocs were shown to have seasonal variations from as low as 17mgg(-1) dry matter (DM) in summer up to 51mg(gDM)(-1) in winter, which correlated with an increased occurrence of filamentous bacteria in the colder season. Therefore, it was investigated at pilot-scale MBRs with different sludge retention times (SRTs) whether different EPS contents and corresponding sludge properties influence membrane fouling. Activated sludge from the pilot MBR with low SRT (23d) was found to have worse filterability, settleability and dewaterability. Photometric analysis of EPS extracts as well as LC-OCD measurements showed that it contained significantly higher concentrations of floc-bound EPS than sludge at higher SRT (40d) The formation of fouling layers on the membranes, characterised by SEM-EDX as well as photometric analysis of EPS extracts, was more distinct at lower SRT where concentrations of deposited EPS were 40-fold higher for proteins and 5-fold higher for carbohydrates compared with the membrane at higher SRT. Floc-bound EPS and metals were suggested to play a role in the fouling process at the full-scale MBR and this was confirmed by the pilot-scale study. However, despite the different sludge properties, the permeability of membranes was found to be similar.

  20. Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8.

    PubMed

    Auciello, Giulio; Cunningham, Debbie L; Tatar, Tulin; Heath, John K; Rappoport, Joshua Z

    2013-01-15

    Fibroblast growth factor receptors (FGFRs) mediate a wide spectrum of cellular responses that are crucial for development and wound healing. However, aberrant FGFR activity leads to cancer. Activated growth factor receptors undergo stimulated endocytosis, but can continue to signal along the endocytic pathway. Endocytic trafficking controls the duration and intensity of signalling, and growth factor receptor signalling can lead to modifications of trafficking pathways. We have developed live-cell imaging methods for studying FGFR dynamics to investigate mechanisms that coordinate the interplay between receptor trafficking and signal transduction. Activated FGFR enters the cell following recruitment to pre-formed clathrin-coated pits (CCPs). However, FGFR activation stimulates clathrin-mediated endocytosis; FGF treatment increases the number of CCPs, including those undergoing endocytosis, and this effect is mediated by Src and its phosphorylation target Eps8. Eps8 interacts with the clathrin-mediated endocytosis machinery and depletion of Eps8 inhibits FGFR trafficking and immediate Erk signalling. Once internalized, FGFR passes through peripheral early endosomes en route to recycling and degredative compartments, through an Src- and Eps8-dependent mechanism. Thus Eps8 functions as a key coordinator in the interplay between FGFR signalling and trafficking. This work provides the first detailed mechanistic analysis of growth factor receptor clustering at the cell surface through signal transduction and endocytic trafficking. As we have characterised the Src target Eps8 as a key regulator of FGFR signalling and trafficking, and identified the early endocytic system as the site of Eps8-mediated effects, this work provides novel mechanistic insight into the reciprocal regulation of growth factor receptor signalling and trafficking.

  1. Role of the pharmacist in pre-exposure chemoprophylaxis (PrEP) therapy for HIV prevention

    PubMed Central

    Clauson, Kevin A.; Polen, Hyla H.; Joseph, Shine A.; Zapantis, Antonia

    2008-01-01

    With a global estimate of 2.5 million new infections of HIV occurring yearly, discovering novel methods to help stem the spread of the virus is critical. The use of antiretroviral chemoprophylaxis for preventing HIV after accidental or occupational exposure and in maternal to fetal transmission has become a widely accepted method to combat HIV. Based on this success, pre-exposure chemoprophylaxis (PrEP) is being explored in at-risk patient populations such as injecting drug users, female sex workers and men who have sex with men. This off-label and unmonitored use has created a need for education and intervention by pharmacists and other healthcare professionals. Pharmacists should educate themselves on PrEP and be prepared to counsel patients about their means of obtaining it (e.g. borrowing or sharing medications and ordering from disreputable Internet pharmacies). They should also be proactive about medication therapy management in these patients due to clinically important drug interactions with PrEP medications. Only one trial exploring the safety and efficacy of tenofovir as PrEP has been completed thus far. However, five ongoing trials are in various stages and two additional studies are scheduled for the near future. Unfortunately, studies in this arena have met with many challenges that have threatened to derail progress. Ethical controversy surrounding post-trial care of participants who seroconvert during studies, as well as concerns over emerging viral resistance and logistical site problems, have already halted several PrEP trials. Information about these early trials has already filtered down to affected individuals who are experimenting with this unproven therapy as an “evening before pill”. The potential for PrEP is promising; however, more extensive trials are necessary to establish its safety and efficacy. Pharmacists are well-positioned to play a key role in helping patients make choices about PrEP, managing their therapy, and developing

  2. EP24.15 as a Potential Regulator of Kisspeptin Within the Neuroendocrine Hypothalamus

    PubMed Central

    Woitowich, Nicole C.; Philibert, Keith D.; Leitermann, Randy J.; Wungjiranirun, Manida

    2016-01-01

    The neuropeptide kisspeptin (Kiss1) is integral to the advent of puberty and the generation of cyclical LH surges. Although many complex actions of Kiss1 are known, the mechanisms governing the processing/regulation of this peptide have not been unveiled. The metallo enzyme, endopeptidase 24.15 (thimet oligopeptidase), has been demonstrated to play a key role in the processing and thus the duration of action of the reproductive neuropeptide, GnRH, which signals downstream of Kiss1. Initial in silico modeling implied that Kiss1 could also be a putative substrate for EP24.15. Coincubation of Kiss1 and EP24.15 demonstrated multiple cleavages of the peptide predominantly between Arg29-Gly30 and Ser47-Phe48 (corresponding to Ser5-Phe6 in Kiss-10; Kiss-10 as a substrate had an additional cleavage between Phe6-Gly7) as determined by mass spectrometry. Vmax for the reaction was 2.37±0.09 pmol/min · ng with a Km of 19.68 ± 2.53μM, which is comparable with other known substrates of EP24.15. EP24.15 immunoreactivity, as previously demonstrated, is distributed in cell bodies, nuclei, and processes throughout the hypothalamus. Kiss1 immunoreactivity is localized primarily to cell bodies and fibers within the mediobasal and anteroventral-periventricular hypothalamus. Double-label immunohistochemistry indicated coexpression of EP24.15 and Kiss1, implicating that the regulation of Kiss1 by EP24.15 could occur in vivo. Further studies will be directed at determining the precise temporal sequence of EP24.15 effects on Kiss1 as it relates to the control of reproductive hormone secretion and treatment of fertility issues. PMID:26653570

  3. Role of the pharmacist in pre-exposure chemoprophylaxis (PrEP) therapy for HIV prevention.

    PubMed

    Clauson, Kevin A; Polen, Hyla H; Joseph, Shine A; Zapantis, Antonia

    2009-01-01

    With a global estimate of 2.5 million new infections of HIV occurring yearly, discovering novel methods to help stem the spread of the virus is critical. The use of antiretroviral chemoprophylaxis for preventing HIV after accidental or occupational exposure and in maternal to fetal transmission has become a widely accepted method to combat HIV. Based on this success, pre-exposure chemoprophylaxis (PrEP) is being explored in at-risk patient populations such as injecting drug users, female sex workers and men who have sex with men. This off-label and unmonitored use has created a need for education and intervention by pharmacists and other healthcare professionals. Pharmacists should educate themselves on PrEP and be prepared to counsel patients about their means of obtaining it (e.g. borrowing or sharing medications and ordering from disreputable Internet pharmacies). They should also be proactive about medication therapy management in these patients due to clinically important drug interactions with PrEP medications. Only one trial exploring the safety and efficacy of tenofovir as PrEP has been completed thus far. However, five ongoing trials are in various stages and two additional studies are scheduled for the near future. Unfortunately, studies in this arena have met with many challenges that have threatened to derail progress. Ethical controversy surrounding post-trial care of participants who seroconvert during studies, as well as concerns over emerging viral resistance and logistical site problems, have already halted several PrEP trials. Information about these early trials has already filtered down to affected individuals who are experimenting with this unproven therapy as an "evening before pill". The potential for PrEP is promising; however, more extensive trials are necessary to establish its safety and efficacy. Pharmacists are well-positioned to play a key role in helping patients make choices about PrEP, managing their therapy, and developing policy

  4. Review of two-photon exchange in electron scattering

    SciTech Connect

    J. Arrington, P. G. Blunden, W. Melnitchouk

    2011-10-01

    We review the role of two-photon exchange (TPE) in electron-hadron scattering, focusing in particular on hadronic frameworks suitable for describing the low and moderate Q^2 region relevant to most experimental studies. We discuss the effects of TPE on the extraction of nucleon form factors and their role in the resolution of the proton electric to magnetic form factor ratio puzzl