Rice yellow stunt rhabdovirus protein 6 suppresses systemic RNA silencing by blocking RDR6-mediated secondary siRNA synthesis.

PubMed

Guo, Hongyan; Song, Xiaoguang; Xie, Chuanmiao; Huo, Yan; Zhang, Fujie; Chen, Xiaoying; Geng, Yunfeng; Fang, Rongxiang

2013-08-01

The P6 protein of Rice yellow stunt rhabdovirus (RYSV) is a virion structural protein that can be phosphorylated in vitro. However its exact function remains elusive. We found that P6 enhanced the virulence of Potato virus X (PVX) in Nicotiana benthamiana and N. tabacum plants, suggesting that it might function as a suppressor of RNA silencing. We examined the mechanism of P6-mediated silencing suppression by transiently expressing P6 in both N. benthamiana leaves and rice protoplasts. Our results showed that P6 could repress the production of secondary siRNAs and inhibit systemic green fluorescent protein RNA silencing but did not interfere with local RNA silencing in N. benthamiana plants or in rice protoplasts. Intriguingly, P6 and RDR6 had overlapping subcellular localization and P6 bound both rice and Arabidopsis RDR6 in vivo. Furthermore, transgenic rice plants expressing P6 showed enhanced susceptibility to infection by Rice stripe virus. Hence, we propose that P6 is part of the RYSV's counter-defense machinery against the plant RNA silencing system and plays a role mainly in affecting RDR6-mediated secondary siRNA synthesis. Our work provides a new perspective on how a plant-infecting nucleorhabdovirus may counteract host RNA silencing-mediated antiviral defense.

Free radical-mediated systemic immunity in plants.

PubMed

Wendehenne, David; Gao, Qing-Ming; Kachroo, Aardra; Kachroo, Pradeep

2014-08-01

Systemic acquired resistance (SAR) is a form of defense that protects plants against a broad-spectrum of secondary infections by related or unrelated pathogens. SAR related research has witnessed considerable progress in recent years and a number of chemical signals and proteins contributing to SAR have been identified. All of these diverse constituents share their requirement for the phytohormone salicylic acid, an essential downstream component of the SAR pathway. However, recent work demonstrating the essential parallel functioning of nitric oxide (NO)-derived and reactive oxygen species (ROS)-derived signaling together with SA provides important new insights in the overlapping pathways leading to SAR. This review discusses the potential significance of branched pathways and the relative contributions of NO/ROS-derived and SA-derived pathways in SAR. Copyright © 2014 Elsevier Ltd. All rights reserved.

Emotional Hypochondriasis, Hyperbole, and the Borderline Patient

PubMed Central

ZANARINI, MARY C.; FRANKENBURG, FRANCES R.

1994-01-01

The authors define a new defense mechanism, emotional hypochondriasis, that is hypothesized to be central to borderline psychopathology. The behavioral manifestation of this defense—the hyperbolic stance of the borderline patient—is also defined and related to the complex phenomenology of borderline personality disorder. Borderline patients are seen as making an active attempt to maintain a tolerable, if tenuous, adaptation in the face of tremendous subjective emotional pain that has been shaped in large measure by traumatic childhood events that have never been validated. Twelve treatment implications and three expectable, if overlapping, stages of treatment stemming from the use of this defense and its behavioral sequelae are detailed. PMID:22700171

Frigate Defense Effectiveness in Asymmetrical Green Water Engagements

DTIC Science & Technology

2009-09-01

the model not employ- ing a helicopter, a high overlap in the sets of factors determining loss is observed. Both factor weighting and the predicted...61 4.1 Model Parameter Estimates Overview. . . . . . . . . . . . . . . . . . . . . . 69 4.2 Distribution of loss ...74 4.7 The range at which a contact is deemed hostile has low impact on predicted loss

Song matching, overlapping, and switching in the banded wren: the sender’s perspective

PubMed Central

Vehrencamp, Sandra L.; Hall, Michelle L.; Bohman, Erin R.; Depeine, Catherine D.; Dalziell, Anastasia H.

2008-01-01

Interpreting receiver responses to on-territory playback of aggressive signals is problematic. One solution is to combine such receiver-perspective experiments with a sender-perspective experiment that allows subjects to demonstrate how their choice of singing strategies is associated with their approach behavior. Here we report the results of a sender-perspective study on the banded wren (Thryothorus pleurostictus), and combine information on context and results of previous receiver-perspective experiments to clarify function. Territorial males were presented with a 5-min playback consisting of song types present in their repertoire. We assessed the degree to which the subjects’ song matching rate, overlapping rate, and song-type versatility were correlated with their approach latency, closeness of approach, latency to first retreat, and time spent close to the speaker. Male age, breeding stage, and features of the playback stimuli were also considered. Song matching was associated with rapid and close approach, consistent with the receiver-perspective interpretation of type matching as a conventional signal of aggressive motivation. Overlapping was associated with earlier retreat, and together with the aversive receiver response to our previous overlapping playback experiment suggests that overlapping is a defensive withdrawal signal. High versatility was associated with slower first retreat from the speaker and high levels of reciprocal matching between subject and playback. Males with fledglings sang with particularly low versatility and approached the speaker aggressively, whereas males with nestlings overlapped more and retreated quickly. Finally, older males matched more but overlapped less. PMID:18392112

The role of ROS signaling in cross-tolerance: from model to crop

PubMed Central

Perez, Ilse Barrios; Brown, Patrick J.

2014-01-01

Reactive oxygen species (ROS) are key signaling molecules produced in response to biotic and abiotic stresses that trigger a variety of plant defense responses. Cross-tolerance, the enhanced ability of a plant to tolerate multiple stresses, has been suggested to result partly from overlap between ROS signaling mechanisms. Cross-tolerance can manifest itself both as a positive genetic correlation between tolerance to different stresses (inherent cross-tolerance), and as the priming of systemic plant tolerance through previous exposure to another type of stress (induced cross-tolerance). Research in model organisms suggests that cross-tolerance could be used to benefit the agronomy and breeding of crop plants. However, research under field conditions has been scarce and critical issues including the timing, duration, and intensity of a stressor, as well as its interactions with other biotic and abiotic factors, remain to be addressed. Potential applications include the use of chemical stressors to screen for stress-resistant genotypes in breeding programs and the agronomic use of chemical inducers of plant defense for plant protection. Success of these applications will rely on improving our understanding of how ROS signals travel systemically and persist over time, and of how genetic correlations between resistance to ROS, biotic, and abiotic stresses are shaped by cooperative and antagonistic interactions within the underlying signaling pathways. PMID:25566313

Investigating Concurrency in Weapons Programs

DTIC Science & Technology

2010-10-01

manipulation. Defense AT&L: September-October 2010 20 acquisition’s Feb. 6, 2006, memorandum, “Design/Build Con - currency,” identified the high degree...We have consistently reported on the elevated risk of poor program outcomes from the substantial overlap of development, test, and production...rency a program can experience before significant cost increase is incurred rages on. Advantages and Disadvantages Intuitively, one can see the

The Tangled World of Teacher Debt: Clashing Rules and Uncertain Benefits for Federal Student-Loan Subsidies

ERIC Educational Resources Information Center

Delisle, Jason; Holt, Alexander

2017-01-01

The world of student loans and debt forgiveness for teachers is a patchwork of overlapping programs, contradictory regulations, and expensive subsidies that date back to Dwight D. Eisenhower's signing of the National Defense Education Act of 1958. The 60-year experiment in using federal loan dollars to encourage students to become teachers could…

Science-based stockpile stewardship at LANSCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Browne, J.

1995-10-01

Let me tell you a little about the Los Alamos Neutron Science Center (LANSCE) and how some of the examples you heard about from Sig Hecker and John Immele fit together in this view of a different world in the future where defense, basic and industrial research overlap. I am going to talk about science-based stockpile stewardship at LANSCE; the accelerator production of tritium (APT), which I think has a real bearing on the neutron road map; the world-class neutron science user facility, for which I will provide some examples so you can see the connection with defense science; andmore » lastly, testing concepts for a high-power spallation neutron target and waste transmutation.« less

Increasing security through public health: a practical model.

PubMed

Parker, R David

2011-01-01

As political and social changes sweep the globe, there are opportunities to increase national security through innovative approaches. While traditional security methods such as defense forces and homeland security provide both pre-emptive and defensive protection, new methods could meet emerging challenges by responding to the political, financial, and social trends. One method is the integration of defense, medicine and public health. By assisting a nation by providing basic services, such as healthcare, collaborative efforts can increase stabilization in areas of unrest. Improved health outcomes leads to increased domestic security, which can create a ripple effect across a region. Assessment, uptake and sustainability by the host nation are critical for program success. The proposed methodology focuses on the use of primarily extant resources, such as programs used by Special Operations Forces and other health and defense programs. Additional components include evaluation, set objectives and mission collaborations. As the nexus between foreign affairs, security, and public health is increasingly validated through research and practice, standardized interventions should be developed to minimize overlapping expenditures, promote security and strengthen international relations. 2011.

Joint Professional Military Education: Opportunities Exist for Greater Oversight and Coordination of Associated Research Institutions

DTIC Science & Technology

2014-03-01

research requests across the department exposes DOD to the risk of potential overlap of studies and analysis research. View GAO-14-216. For more...National Defense University GPRA Government Performance and Results Act CCO Center for Complex Operations CSR Center for Strategic...their future leadership positions. To provide broad educational experiences, students can conduct research at the JPME research institutions as part

Comparative genomics of defense systems in archaea and bacteria

PubMed Central

Makarova, Kira S.; Wolf, Yuri I.; Koonin, Eugene V.

2013-01-01

Our knowledge of prokaryotic defense systems has vastly expanded as the result of comparative genomic analysis, followed by experimental validation. This expansion is both quantitative, including the discovery of diverse new examples of known types of defense systems, such as restriction-modification or toxin-antitoxin systems, and qualitative, including the discovery of fundamentally new defense mechanisms, such as the CRISPR-Cas immunity system. Large-scale statistical analysis reveals that the distribution of different defense systems in bacterial and archaeal taxa is non-uniform, with four groups of organisms distinguishable with respect to the overall abundance and the balance between specific types of defense systems. The genes encoding defense system components in bacterial and archaea typically cluster in defense islands. In addition to genes encoding known defense systems, these islands contain numerous uncharacterized genes, which are candidates for new types of defense systems. The tight association of the genes encoding immunity systems and dormancy- or cell death-inducing defense systems in prokaryotic genomes suggests that these two major types of defense are functionally coupled, providing for effective protection at the population level. PMID:23470997

Clarifying the Role of Defensive Reactivity Deficits in Psychopathy and Antisocial Personality Using Startle Reflex Methodology

PubMed Central

Vaidyanathan, Uma; Hall, Jason R.; Patrick, Christopher J.; Bernat, Edward M.

2010-01-01

Prior research has demonstrated deficits in defensive reactivity (indexed by potentiation of the startle blink reflex) in psychopathic individuals. However, the basis of this association remains unclear, as diagnostic criteria for psychopathy encompass two distinct phenotypic components that may reflect differing neurobiological mechanisms – an affective-interpersonal component, and an antisocial deviance component. Likewise, the role of defensive response deficits in antisocial personality disorder (APD), a related but distinct syndrome, remains to be clarified. The current study examined affective priming deficits in relation to factors of psychopathy and symptoms of APD using startle reflex methods in 108 adult male prisoners. Deficits in blink reflex potentiation during aversive picture viewing were found in relation to the affective-interpersonal (Factor 1) component of psychopathy, and to a lesser extent in relation to the antisocial deviance (Factor 2) component of psychopathy and symptoms of APD—but only as a function of their overlap with affective-interpersonal features of psychopathy. These findings provide clear evidence that deficits in defensive reactivity are linked specifically to the affective-interpersonal features of psychopathy, and not the antisocial deviance features represented most strongly in APD. PMID:20973594

Phosphorylation of a NAC Transcription Factor by a Calcium/Calmodulin-Dependent Protein Kinase Regulates Abscisic Acid-Induced Antioxidant Defense in Maize [Phosphorylation of a NAC Transcription Factor by ZmCCaMK Regulates Abscisic Acid-Induced Antioxidant Defense in Maize

DOE PAGES

Zhu, Yuan; Yan, Jingwei; Liu, Weijuan; ...

2016-05-10

Calcium/calmodulin-dependent protein kinase (CCaMK) has been shown to play an important role in abscisic acid (ABA)-induced antioxidant defense and enhance the tolerance of plants to drought stress. However, its downstream molecular events are poorly understood. Here, we identify a NAC transcription factor, ZmNAC84, in maize, which physically interacts with ZmCCaMK in vitro and in vivo. ZmNAC84 display a partially overlapping expression pattern with ZmCCaMK after ABA treatment and H 2O 2 is required for ABA-induced ZmNAC84 expression. Functional analysis reveals that ZmNAC84 is essential for ABA-induced antioxidant defense in a ZmCCaMK-dependent manner. Furthermore, ZmCCaMK directly phosphorylates S113 of ZmNAC84 inmore » vitro, and S113 is essential for the ABA-induced stimulation of antioxidant defense by ZmCCaMK. Moreover, overexpression of ZmNAC84 in tobacco can improve drought tolerance, and alleviate drought-induced oxidative damage of transgenic plants. These results define a mechanism for ZmCCaMK function in ABA-induced antioxidant defense, where ABA-produced H 2O 2 first induces expression of ZmCCaMK and ZmNAC84 and activates ZmCCaMK, and subsequently the activated ZmCCaMK phosphorylates ZmNAC84 at S113, thereby inducing antioxidant defense by activating downstream genes.« less

Phosphorylation of a NAC Transcription Factor by a Calcium/Calmodulin-Dependent Protein Kinase Regulates Abscisic Acid-Induced Antioxidant Defense in Maize [Phosphorylation of a NAC Transcription Factor by ZmCCaMK Regulates Abscisic Acid-Induced Antioxidant Defense in Maize

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Yuan; Yan, Jingwei; Liu, Weijuan

Calcium/calmodulin-dependent protein kinase (CCaMK) has been shown to play an important role in abscisic acid (ABA)-induced antioxidant defense and enhance the tolerance of plants to drought stress. However, its downstream molecular events are poorly understood. Here, we identify a NAC transcription factor, ZmNAC84, in maize, which physically interacts with ZmCCaMK in vitro and in vivo. ZmNAC84 display a partially overlapping expression pattern with ZmCCaMK after ABA treatment and H 2O 2 is required for ABA-induced ZmNAC84 expression. Functional analysis reveals that ZmNAC84 is essential for ABA-induced antioxidant defense in a ZmCCaMK-dependent manner. Furthermore, ZmCCaMK directly phosphorylates S113 of ZmNAC84 inmore » vitro, and S113 is essential for the ABA-induced stimulation of antioxidant defense by ZmCCaMK. Moreover, overexpression of ZmNAC84 in tobacco can improve drought tolerance, and alleviate drought-induced oxidative damage of transgenic plants. These results define a mechanism for ZmCCaMK function in ABA-induced antioxidant defense, where ABA-produced H 2O 2 first induces expression of ZmCCaMK and ZmNAC84 and activates ZmCCaMK, and subsequently the activated ZmCCaMK phosphorylates ZmNAC84 at S113, thereby inducing antioxidant defense by activating downstream genes.« less

The nuclear immune receptor RPS4 is required for RRS1SLH1-dependent constitutive defense activation in Arabidopsis thaliana.

PubMed

Sohn, Kee Hoon; Segonzac, Cécile; Rallapalli, Ghanasyam; Sarris, Panagiotis F; Woo, Joo Yong; Williams, Simon J; Newman, Toby E; Paek, Kyung Hee; Kobe, Bostjan; Jones, Jonathan D G

2014-10-01

Plant nucleotide-binding leucine-rich repeat (NB-LRR) disease resistance (R) proteins recognize specific "avirulent" pathogen effectors and activate immune responses. NB-LRR proteins structurally and functionally resemble mammalian Nod-like receptors (NLRs). How NB-LRR and NLR proteins activate defense is poorly understood. The divergently transcribed Arabidopsis R genes, RPS4 (resistance to Pseudomonas syringae 4) and RRS1 (resistance to Ralstonia solanacearum 1), function together to confer recognition of Pseudomonas AvrRps4 and Ralstonia PopP2. RRS1 is the only known recessive NB-LRR R gene and encodes a WRKY DNA binding domain, prompting suggestions that it acts downstream of RPS4 for transcriptional activation of defense genes. We define here the early RRS1-dependent transcriptional changes upon delivery of PopP2 via Pseudomonas type III secretion. The Arabidopsis slh1 (sensitive to low humidity 1) mutant encodes an RRS1 allele (RRS1SLH1) with a single amino acid (leucine) insertion in the WRKY DNA-binding domain. Its poor growth due to constitutive defense activation is rescued at higher temperature. Transcription profiling data indicate that RRS1SLH1-mediated defense activation overlaps substantially with AvrRps4- and PopP2-regulated responses. To better understand the genetic basis of RPS4/RRS1-dependent immunity, we performed a genetic screen to identify suppressor of slh1 immunity (sushi) mutants. We show that many sushi mutants carry mutations in RPS4, suggesting that RPS4 acts downstream or in a complex with RRS1. Interestingly, several mutations were identified in a domain C-terminal to the RPS4 LRR domain. Using an Agrobacterium-mediated transient assay system, we demonstrate that the P-loop motif of RPS4 but not of RRS1SLH1 is required for RRS1SLH1 function. We also recapitulate the dominant suppression of RRS1SLH1 defense activation by wild type RRS1 and show this suppression requires an intact RRS1 P-loop. These analyses of RRS1SLH1 shed new light on mechanisms by which NB-LRR protein pairs activate defense signaling, or are held inactive in the absence of a pathogen effector.

The Nuclear Immune Receptor RPS4 Is Required for RRS1SLH1-Dependent Constitutive Defense Activation in Arabidopsis thaliana

PubMed Central

Sarris, Panagiotis F.; Woo, Joo Yong; Williams, Simon J.; Newman, Toby E.; Paek, Kyung Hee; Kobe, Bostjan; Jones, Jonathan D. G.

2014-01-01

Plant nucleotide-binding leucine-rich repeat (NB-LRR) disease resistance (R) proteins recognize specific “avirulent” pathogen effectors and activate immune responses. NB-LRR proteins structurally and functionally resemble mammalian Nod-like receptors (NLRs). How NB-LRR and NLR proteins activate defense is poorly understood. The divergently transcribed Arabidopsis R genes, RPS4 (resistance to Pseudomonas syringae 4) and RRS1 (resistance to Ralstonia solanacearum 1), function together to confer recognition of Pseudomonas AvrRps4 and Ralstonia PopP2. RRS1 is the only known recessive NB-LRR R gene and encodes a WRKY DNA binding domain, prompting suggestions that it acts downstream of RPS4 for transcriptional activation of defense genes. We define here the early RRS1-dependent transcriptional changes upon delivery of PopP2 via Pseudomonas type III secretion. The Arabidopsis slh1 (sensitive to low humidity 1) mutant encodes an RRS1 allele (RRS1SLH1) with a single amino acid (leucine) insertion in the WRKY DNA-binding domain. Its poor growth due to constitutive defense activation is rescued at higher temperature. Transcription profiling data indicate that RRS1SLH1-mediated defense activation overlaps substantially with AvrRps4- and PopP2-regulated responses. To better understand the genetic basis of RPS4/RRS1-dependent immunity, we performed a genetic screen to identify suppressor of slh1 immunity (sushi) mutants. We show that many sushi mutants carry mutations in RPS4, suggesting that RPS4 acts downstream or in a complex with RRS1. Interestingly, several mutations were identified in a domain C-terminal to the RPS4 LRR domain. Using an Agrobacterium-mediated transient assay system, we demonstrate that the P-loop motif of RPS4 but not of RRS1SLH1 is required for RRS1SLH1 function. We also recapitulate the dominant suppression of RRS1SLH1 defense activation by wild type RRS1 and show this suppression requires an intact RRS1 P-loop. These analyses of RRS1SLH1 shed new light on mechanisms by which NB-LRR protein pairs activate defense signaling, or are held inactive in the absence of a pathogen effector. PMID:25340333

Developing an Adaptability Training Strategy and Policy for the Department of Defense (DOD)

DTIC Science & Technology

2010-08-01

reach a broad audience, and do so much more inexpensively than would be the case with live simulations. With this in mind, we attended the annual...authors acknowledge ongoing debates about the relationship between training and education. Because the military makes a distinction between training...programs and educational programs, we simply accept that both are vehicles for learning and that there is an overlap between the two. 23 See for

75 FR 65439 - Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting System

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-25

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 219 and 252 [DFARS Case... System AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Interim rule... Supplement (DFARS) to conform to the Federal Acquisition Regulation (FAR) by providing Department of Defense...

Bacillus subtilis extracytoplasmic function (ECF) sigma factors and defense of the cell envelope

PubMed Central

Helmann, John D.

2016-01-01

Summary Bacillus subtilis provides a model for investigation of the bacterial cell envelope, the first line of defense against environmental threats. Extracytoplasmic function (ECF) sigma factors activate genes that confer resistance to agents that threaten the integrity of the envelope. Although their individual regulons overlap, σW is most closely associated with membrane-active agents, σX with cationic antimicrobial peptide resistance, and σV with resistance to lysozyme. Here, I highlight the role of the σM regulon, which is strongly induced by conditions that impair peptidoglycan synthesis and includes the core pathways of envelope synthesis and cell division, as well as stress-inducible alternative enzymes. Studies of these cell envelope stress responses provide insights into how bacteria acclimate to the presence of antibiotics. PMID:26901131

NATO and the Challenges of Austerity

DTIC Science & Technology

2012-01-01

Navy’s participation in operations in Libya in 2011. The The Impact of Defense Cuts on Key NATO Allies 7 elimination of the Nimrod MRA.4 maritime... Nimrod MRA. Mk2. The CSR cuts included the entire fleet of Harrier GR.9 combat aircraft. The Harrier cut has joint implications because the RAF Har- riers...overlap of its replacement. The Boeing RC-135 “Rivet Joint” signals intelligence (SIGINT) aircraft will replace the two remaining Nimrod R.1 platforms

Department of Defense Healthcare Management System Modernization (DHMSM)

DTIC Science & Technology

2016-03-01

2016 Major Automated Information System Annual Report Department of Defense Healthcare Management System Modernization (DHMSM) Defense...DSN Fax: Date Assigned: November 16, 2015 Program Information Program Name Department of Defense Healthcare Management System Modernization...DHMSM) DoD Component DoD The acquiring DoD Component is Program Executive Office (PEO) Department of Defense (DoD) Healthcare Management Systems (DHMS

Defense Islands in Bacterial and Archaeal Genomes and Prediction of Novel Defense Systems ▿†‡

PubMed Central

Makarova, Kira S.; Wolf, Yuri I.; Snir, Sagi; Koonin, Eugene V.

2011-01-01

The arms race between cellular life forms and viruses is a major driving force of evolution. A substantial fraction of bacterial and archaeal genomes is dedicated to antivirus defense. We analyzed the distribution of defense genes and typical mobilome components (such as viral and transposon genes) in bacterial and archaeal genomes and demonstrated statistically significant clustering of antivirus defense systems and mobile genes and elements in genomic islands. The defense islands are enriched in putative operons and contain numerous overrepresented gene families. A detailed sequence analysis of the proteins encoded by genes in these families shows that many of them are diverged variants of known defense system components, whereas others show features, such as characteristic operonic organization, that are suggestive of novel defense systems. Thus, genomic islands provide abundant material for the experimental study of bacterial and archaeal antivirus defense. Except for the CRISPR-Cas systems, different classes of defense systems, in particular toxin-antitoxin and restriction-modification systems, show nonrandom clustering in defense islands. It remains unclear to what extent these associations reflect functional cooperation between different defense systems and to what extent the islands are genomic “sinks” that accumulate diverse nonessential genes, particularly those acquired via horizontal gene transfer. The characteristics of defense islands resemble those of mobilome islands. Defense and mobilome genes are nonrandomly associated in islands, suggesting nonadaptive evolution of the islands via a preferential attachment-like mechanism underpinned by the addictive properties of defense systems such as toxins-antitoxins and an important role of horizontal mobility in the evolution of these islands. PMID:21908672

Defense islands in bacterial and archaeal genomes and prediction of novel defense systems.

PubMed

Makarova, Kira S; Wolf, Yuri I; Snir, Sagi; Koonin, Eugene V

2011-11-01

The arms race between cellular life forms and viruses is a major driving force of evolution. A substantial fraction of bacterial and archaeal genomes is dedicated to antivirus defense. We analyzed the distribution of defense genes and typical mobilome components (such as viral and transposon genes) in bacterial and archaeal genomes and demonstrated statistically significant clustering of antivirus defense systems and mobile genes and elements in genomic islands. The defense islands are enriched in putative operons and contain numerous overrepresented gene families. A detailed sequence analysis of the proteins encoded by genes in these families shows that many of them are diverged variants of known defense system components, whereas others show features, such as characteristic operonic organization, that are suggestive of novel defense systems. Thus, genomic islands provide abundant material for the experimental study of bacterial and archaeal antivirus defense. Except for the CRISPR-Cas systems, different classes of defense systems, in particular toxin-antitoxin and restriction-modification systems, show nonrandom clustering in defense islands. It remains unclear to what extent these associations reflect functional cooperation between different defense systems and to what extent the islands are genomic "sinks" that accumulate diverse nonessential genes, particularly those acquired via horizontal gene transfer. The characteristics of defense islands resemble those of mobilome islands. Defense and mobilome genes are nonrandomly associated in islands, suggesting nonadaptive evolution of the islands via a preferential attachment-like mechanism underpinned by the addictive properties of defense systems such as toxins-antitoxins and an important role of horizontal mobility in the evolution of these islands.

76 FR 36905 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Taxes

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2011-06-23

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76 FR 8303 - Defense Federal Acquisition Regulation Supplement; Award-Fee Contracts (DFARS Case 2006-D021)

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78 FR 41331 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

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2013-07-10

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How Human Amygdala and Bed Nucleus of the Stria Terminalis May Drive Distinct Defensive Responses.

PubMed

Klumpers, Floris; Kroes, Marijn C W; Baas, Johanna M P; Fernández, Guillén

2017-10-04

The ability to adaptively regulate responses to the proximity of potential danger is critical to survival and imbalance in this system may contribute to psychopathology. The bed nucleus of the stria terminalis (BNST) is implicated in defensive responding during uncertain threat anticipation whereas the amygdala may drive responding upon more acute danger. This functional dissociation between the BNST and amygdala is however controversial, and human evidence scarce. Here we used data from two independent functional magnetic resonance imaging studies [ n = 108 males and n = 70 (45 females)] to probe how coordination between the BNST and amygdala may regulate responses during shock anticipation and actual shock confrontation. In a subset of participants from Sample 2 ( n = 48) we demonstrate that anticipation and confrontation evoke bradycardic and tachycardic responses, respectively. Further, we show that in each sample when going from shock anticipation to the moment of shock confrontation neural activity shifted from a region anatomically consistent with the BNST toward the amygdala. Comparisons of functional connectivity during threat processing showed overlapping yet also consistently divergent functional connectivity profiles for the BNST and amygdala. Finally, childhood maltreatment levels predicted amygdala, but not BNST, hyperactivity during shock anticipation. Our results support an evolutionary conserved, defensive distance-dependent dynamic balance between BNST and amygdala activity. Shifts in this balance may enable shifts in defensive reactions via the demonstrated differential functional connectivity. Our results indicate that early life stress may tip the neural balance toward acute threat responding and via that route predispose for affective disorder. SIGNIFICANCE STATEMENT Previously proposed differential contributions of the BNST and amygdala to fear and anxiety have been recently debated. Despite the significance of understanding their contributions to defensive reactions, there is a paucity of human studies that directly compared these regions on activity and connectivity during threat processing. We show strong evidence for a dissociable role of the BNST and amygdala in threat processing by demonstrating in two large participant samples that they show a distinct temporal signature of threat responding as well as a discriminable pattern of functional connections and differential sensitivity to early life threat. Copyright © 2017 the authors 0270-6474/17/379645-12$15.00/0.

78 FR 18877 - Defense Federal Acquisition Regulation Supplement; Specialty Metals-Definition of “Produce...

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2013-03-28

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Bacillus subtilis extracytoplasmic function (ECF) sigma factors and defense of the cell envelope.

PubMed

Helmann, John D

2016-04-01

Bacillus subtilis provides a model for investigation of the bacterial cell envelope, the first line of defense against environmental threats. Extracytoplasmic function (ECF) sigma factors activate genes that confer resistance to agents that threaten the integrity of the envelope. Although their individual regulons overlap, σ(W) is most closely associated with membrane-active agents, σ(X) with cationic antimicrobial peptide resistance, and σ(V) with resistance to lysozyme. Here, I highlight the role of the σ(M) regulon, which is strongly induced by conditions that impair peptidoglycan synthesis and includes the core pathways of envelope synthesis and cell division, as well as stress-inducible alternative enzymes. Studies of these cell envelope stress responses provide insights into how bacteria acclimate to the presence of antibiotics. Copyright © 2016 Elsevier Ltd. All rights reserved.

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... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0454] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Administrative Matters AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice; request for...

78 FR 70294 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-25

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [Docket Number DARS 2013-0046] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Administrative Matters AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice and request...

Spacecraft Dynamics and Control Program at AFRPL

NASA Technical Reports Server (NTRS)

Das, A.; Slimak, L. K. S.; Schloegel, W. T.

1986-01-01

A number of future DOD and NASA spacecraft such as the space based radar will be not only an order of magnitude larger in dimension than the current spacecraft, but will exhibit extreme structural flexibility with very low structural vibration frequencies. Another class of spacecraft (such as the space defense platforms) will combine large physical size with extremely precise pointing requirement. Such problems require a total departure from the traditional methods of modeling and control system design of spacecraft where structural flexibility is treated as a secondary effect. With these problems in mind, the Air Force Rocket Propulsion Laboratory (AFRPL) initiated research to develop dynamics and control technology so as to enable the future large space structures (LSS). AFRPL's effort in this area can be subdivided into the following three overlapping areas: (1) ground experiments, (2) spacecraft modeling and control, and (3) sensors and actuators. Both the in-house and contractual efforts of the AFRPL in LSS are summarized.

The Defense Systems Acquisition and Review Council

DTIC Science & Technology

1976-09-15

THE DEFENSE SYSTEMS ACQUISITION AND REVIEW COUNCIL.. A Study of Areas of Consideration Affecting the Functions and Process of Defense Major...COUNfIL: 4 Study of Areas of Considerationi Affecting/he Functions and Process of Defense _- 1 Major Systems Acquisition. , ; O,. v AUTHOR(e) I. C...Studies DSARC -- Functions and Process OSDCAIG *, Army Systems . A - =A -- he Defense Systems Acquisition Review Council (DSARC) was created to assume

76 FR 52131 - Defense Federal Acquisition Regulation Supplement; Nonavailability Exception for Procurement of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-19

... Vol. 76 Friday, No. 161 August 19, 2011 Part III Department of Defense Defense Acquisition Regulations System 48 CFR Parts 201, 209, 216, et al. Defense Federal Acquisition Regulation Supplements... DEFENSE Defense Acquisition Regulations System 48 CFR Part 225 RIN 0750-AH17 Defense Federal Acquisition...

Microbial Genomics: The Expanding Universe of Bacterial Defense Systems.

PubMed

Forsberg, Kevin J; Malik, Harmit S

2018-04-23

Bacteria protect themselves against infection using multiple defensive systems that move by horizontal gene transfer and accumulate in genomic 'defense islands'. A recent study exploited these features to uncover ten novel defense systems, substantially expanding the catalog of bacterial defense systems and predicting the discovery of many more. Copyright © 2018 Elsevier Ltd. All rights reserved.

CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis.

PubMed

Zhu, Yingfang; Schluttenhoffer, Craig M; Wang, Pengcheng; Fu, Fuyou; Thimmapuram, Jyothi; Zhu, Jian-Kang; Lee, Sang Yeol; Yun, Dae-Jin; Mengiste, Tesfaye

2014-10-01

CYCLIN-DEPENDENT KINASE8 (CDK8) is a widely studied component of eukaryotic Mediator complexes. However, the biological and molecular functions of plant CDK8 are not well understood. Here, we provide evidence for regulatory functions of Arabidopsis thaliana CDK8 in defense and demonstrate its functional and molecular interactions with other Mediator and non-Mediator subunits. The cdk8 mutant exhibits enhanced resistance to Botrytis cinerea but susceptibility to Alternaria brassicicola. The contributions of CDK8 to the transcriptional activation of defensin gene PDF1.2 and its interaction with MEDIATOR COMPLEX SUBUNIT25 (MED25) implicate CDK8 in jasmonate-mediated defense. Moreover, CDK8 associates with the promoter of AGMATINE COUMAROYLTRANSFERASE to promote its transcription and regulate the biosynthesis of the defense-active secondary metabolites hydroxycinnamic acid amides. CDK8 also interacts with the transcription factor WAX INDUCER1, implying its additional role in cuticle development. In addition, overlapping functions of CDK8 with MED12 and MED13 and interactions between CDK8 and C-type cyclins suggest the conserved configuration of the plant Mediator kinase module. In summary, while CDK8's positive transcriptional regulation of target genes and its phosphorylation activities underpin its defense functions, the impaired defense responses in the mutant are masked by its altered cuticle, resulting in specific resistance to B. cinerea. © 2014 American Society of Plant Biologists. All rights reserved.

RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways1[OPEN

PubMed Central

Bequette, Carlton J.; Fu, Zheng Qing; Loraine, Ann E.

2016-01-01

AINTEGUMENTA (ANT) and AINTEGUMENTA-LIKE6 (AIL6) are two related transcription factors in Arabidopsis (Arabidopsis thaliana) that have partially overlapping roles in several aspects of flower development, including floral organ initiation, identity specification, growth, and patterning. To better understand the biological processes regulated by these two transcription factors, we performed RNA sequencing (RNA-Seq) on ant ail6 double mutants. We identified thousands of genes that are differentially expressed in the double mutant compared with the wild type. Analyses of these genes suggest that ANT and AIL6 regulate floral organ initiation and growth through modifications to the cell wall polysaccharide pectin. We found reduced levels of demethylesterified homogalacturonan and altered patterns of auxin accumulation in early stages of ant ail6 flower development. The RNA-Seq experiment also revealed cross-regulation of AIL gene expression at the transcriptional level. The presence of a number of overrepresented Gene Ontology terms related to plant defense in the set of genes differentially expressed in ant ail6 suggest that ANT and AIL6 also regulate plant defense pathways. Furthermore, we found that ant ail6 plants have elevated levels of two defense hormones: salicylic acid and jasmonic acid, and show increased resistance to the bacterial pathogen Pseudomonas syringae. These results suggest that ANT and AIL6 regulate biological pathways that are critical for both development and defense. PMID:27208279

78 FR 67132 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Contract...

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2013-11-08

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75 FR 45104 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Contract...

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2010-08-02

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78 FR 68830 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Service...

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2013-11-15

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78 FR 68829 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Contract...

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2013-11-15

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75 FR 47561 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Contract...

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2010-08-06

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Contract Financing (OMB Control Number 0704- 0359) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice and request...

48 CFR 225.7902 - Defense Trade Cooperation Treaties.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Defense Trade Cooperation Treaties. 225.7902 Section 225.7902 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION EXPORT CONTROL 225.7902 Defense Trade Cooperation Treaties. This...

48 CFR 225.7902 - Defense Trade Cooperation Treaties.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Defense Trade Cooperation Treaties. 225.7902 Section 225.7902 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION EXPORT CONTROL 225.7902 Defense Trade Cooperation Treaties. This...

Robotic Missions to Small Bodies and Their Potential Contributions to Human Exploration and Planetary Defense

NASA Technical Reports Server (NTRS)

Abell, Paul A.; Rivkin, Andrew S.

2015-01-01

Introduction: Robotic missions to small bodies will directly address aspects of NASA's Asteroid Initiative and will contribute to future human exploration and planetary defense. The NASA Asteroid Initiative is comprised of two major components: the Grand Challenge and the Asteroid Mission. The first component, the Grand Challenge, focuses on protecting Earth's population from asteroid impacts by detecting potentially hazardous objects with enough warning time to either prevent them from impacting the planet, or to implement civil defense procedures. The Asteroid Mission involves sending astronauts to study and sample a near-Earth asteroid (NEA) prior to conducting exploration missions of the Martian system, which includes Phobos and Deimos. The science and technical data obtained from robotic precursor missions that investigate the surface and interior physical characteristics of an object will help identify the pertinent physical properties that will maximize operational efficiency and reduce mission risk for both robotic assets and crew operating in close proximity to, or at the surface of, a small body. These data will help fill crucial strategic knowledge gaps (SKGs) concerning asteroid physical characteristics that are relevant for human exploration considerations at similar small body destinations. These data can also be applied for gaining an understanding of pertinent small body physical characteristics that would also be beneficial for formulating future impact mitigation procedures. Small Body Strategic Knowledge Gaps: For the past several years NASA has been interested in identifying the key SKGs related to future human destinations. These SKGs highlight the various unknowns and/or data gaps of targets that the science and engineering communities would like to have filled in prior to committing crews to explore the Solar System. An action team from the Small Bodies Assessment Group (SBAG) was formed specifically to identify the small body SKGs under the direction of the Human Exploration and Operations Missions Directorate (HEOMD), given NASA's recent interest in NEAs and the Martian moons as potential human destinations. The action team organized the SKGs into four broad themes: 1) Identify human mission targets; 2) Understand how to work on and interact with the small body surface; 3) Understand the small body environment and its potential risk/benefit to crew, systems, and operational assets; and 4) Understand the small body resource potential. Of these four SKG themes, the first three have significant overlap with planetary defense considerations. The data obtained from investigations of small body physical characteristics under these three themes can be directly applicable to planetary defense initiatives. Conclusions: Missions to investigate small bodies can address small body strategic knowledge gaps and contribute to the overall success for human exploration missions to asteroids and the Martian moons. In addition, such reconnaissance of small bodies can also provide a wealth of information relevant to the science and planetary defense of NEAs.

An extension to artifact-free projection overlaps

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Jianyu, E-mail: jianyulin@hotmail.com

2015-05-15

Purpose: In multipinhole single photon emission computed tomography, the overlapping of projections has been used to increase sensitivity. Avoiding artifacts in the reconstructed image associated with projection overlaps (multiplexing) is a critical issue. In our previous report, two types of artifact-free projection overlaps, i.e., projection overlaps that do not lead to artifacts in the reconstructed image, were formally defined and proved, and were validated via simulations. In this work, a new proposition is introduced to extend the previously defined type-II artifact-free projection overlaps so that a broader range of artifact-free overlaps is accommodated. One practical purpose of the new extensionmore » is to design a baffle window multipinhole system with artifact-free projection overlaps. Methods: First, the extended type-II artifact-free overlap was theoretically defined and proved. The new proposition accommodates the situation where the extended type-II artifact-free projection overlaps can be produced with incorrectly reconstructed portions in the reconstructed image. Next, to validate the theory, the extended-type-II artifact-free overlaps were employed in designing the multiplexing multipinhole spiral orbit imaging systems with a baffle window. Numerical validations were performed via simulations, where the corresponding 1-pinhole nonmultiplexing reconstruction results were used as the benchmark for artifact-free reconstructions. The mean square error (MSE) was the metric used for comparisons of noise-free reconstructed images. Noisy reconstructions were also performed as part of the validations. Results: Simulation results show that for noise-free reconstructions, the MSEs of the reconstructed images of the artifact-free multiplexing systems are very similar to those of the corresponding 1-pinhole systems. No artifacts were observed in the reconstructed images. Therefore, the testing results for artifact-free multiplexing systems designed using the extended type-II artifact-free overlaps numerically validated the developed theory. Conclusions: First, the extension itself is of theoretical importance because it broadens the selection range for optimizing multiplexing multipinhole designs. Second, the extension has an immediate application: using a baffle window to design a special spiral orbit multipinhole imaging system with projection overlaps in the orbit axial direction. Such an artifact-free baffle window design makes it possible for us to image any axial portion of interest of a long object with projection overlaps to increase sensitivity.« less

76 FR 50461 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Types of...

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2011-08-15

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75 FR 20825 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-21

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0332] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot Mentor-Protege Program AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION...

76 FR 52139 - Defense Federal Acquisition Regulation Supplement; Government; Property (DFARS Case 2009-D008)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-19

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 201, 245, and 252 RIN...-D008) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule... Department of Defense as ineligible, debarred, or suspended from defense contracts; or (iv) Subject to denial...

77 FR 30366 - Defense Federal Acquisition Regulation Supplement: Contingency Contract Closeout (DFARS Case 2012...

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2012-05-22

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 204 RIN 0750-AH71 Defense...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is issuing a final rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to require...

75 FR 9114 - Defense Federal Acquisition Regulation Supplement; Additional Requirements Applicable to...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-01

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 217 Defense Federal Acquisition Regulation Supplement; Additional Requirements Applicable to Multiyear Contracts (DFARS Case 2008-D023) AGENCY: Defense Acquisition Regulations System. Department of Defense (DoD). ACTION: Interim rule...

75 FR 33271 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Foreign...

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2010-06-11

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0229... AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice and request... Certain Contracts with Foreign Entities for the Conduct of Ballistic Missile Defense Research, Development...

78 FR 13543 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 201, 204, 215, 225, 227, 242, 245, and 252 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is...

32 CFR 21.200 - What is the Defense Grant and Agreement Regulatory System (DGARS)?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false What is the Defense Grant and Agreement Regulatory System (DGARS)? 21.200 Section 21.200 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Defense...

32 CFR 21.200 - What is the Defense Grant and Agreement Regulatory System (DGARS)?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false What is the Defense Grant and Agreement Regulatory System (DGARS)? 21.200 Section 21.200 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Defense...

32 CFR 21.200 - What is the Defense Grant and Agreement Regulatory System (DGARS)?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false What is the Defense Grant and Agreement Regulatory System (DGARS)? 21.200 Section 21.200 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Defense...

32 CFR 21.200 - What is the Defense Grant and Agreement Regulatory System (DGARS)?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false What is the Defense Grant and Agreement Regulatory System (DGARS)? 21.200 Section 21.200 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Defense...

32 CFR 21.200 - What is the Defense Grant and Agreement Regulatory System (DGARS)?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false What is the Defense Grant and Agreement Regulatory System (DGARS)? 21.200 Section 21.200 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Defense...

76 FR 64885 - Defense Federal Acquisition Regulation Supplement: Reporting of Government-Furnished Property...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-19

... property accounting system of record, and the Army requires GFP to be recorded in DPAS as well. Response... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 211 and 252 RIN 0750... (DFARS Case 2012-D001) AGENCIES: Defense Acquisition Regulations System, Department of Defense (DoD...

Evolutionary Genomics of Defense Systems in Archaea and Bacteria*

PubMed Central

Koonin, Eugene V.; Makarova, Kira S.; Wolf, Yuri I.

2018-01-01

Evolution of bacteria and archaea involves an incessant arms race against an enormous diversity of genetic parasites. Accordingly, a substantial fraction of the genes in most bacteria and archaea are dedicated to antiparasite defense. The functions of these defense systems follow several distinct strategies, including innate immunity; adaptive immunity; and dormancy induction, or programmed cell death. Recent comparative genomic studies taking advantage of the expanding database of microbial genomes and metagenomes, combined with direct experiments, resulted in the discovery of several previously unknown defense systems, including innate immunity centered on Argonaute proteins, bacteriophage exclusion, and new types of CRISPR-Cas systems of adaptive immunity. Some general principles of function and evolution of defense systems are starting to crystallize, in particular, extensive gain and loss of defense genes during the evolution of prokaryotes; formation of genomic defense islands; evolutionary connections between mobile genetic elements and defense, whereby genes of mobile elements are repeatedly recruited for defense functions; the partially selfish and addictive behavior of the defense systems; and coupling between immunity and dormancy induction/programmed cell death. PMID:28657885

75 FR 48278 - Defense Federal Acquisition Regulation Supplement; Excessive Pass-Through Charges

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-10

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 215, 231, and 252 [DFARS Case 2006-D057] Defense Federal Acquisition Regulation Supplement; Excessive Pass-Through Charges AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY...

SU-F-I-57: Evaluate and Optimize PET Acquisition Overlap in 18F-FDG Oncology Wholebody PET/CT: Can We Scan PET Faster?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, J; Natwa, M; Hall, NC

Purpose: The longer patient has to remain on the table during PET imaging, the higher the likelihood of motion artifacts due to patient discomfort. This study was to investigate and optimize PET acquisition overlap in 18F-FDG oncology wholebody PET/CT to speed up PET acquisition and improve patient comfort. Methods: Wholebody 18F-FDG PET/CT of phantoms, 8 pre-clinical patients (beagles) and 5 clinical oncology patients were performed in 90s/bed on a time-of-flight Gemini TF 64 system. Imaging of phantoms and beagles was acquired with reduced PET overlaps (40%, 33%, 27%, 20%, 13% and no overlap) in addition to the system default (53%).more » In human studies, 1 or 2 reduced overlaps from the listed options were used to acquire PET/CT sweeps right after the default standard of care imaging. Image quality was blindly reviewed using visual scoring criteria and quantitative SUV assessment. NEMA PET sensitivity was performed under different overlaps. Results: All PET exams demonstrated no significant impact on the visual grades for overlaps >20%. Blinded reviews assigned the best visual scores to PET using overlaps 53%–27%. Reducing overlap to 27% for oncology patients (12-bed) saved an average of ∼40% acquisition time (11min) compared to using the default overlap (18min). No significant SUV variances were found when reducing overlap to half of default for cerebellum, lung, heart, aorta, liver, fat, muscle, bone marrow, thighs and target lesions (p>0.05), except expected variability in urinary system. Conclusion: This study demonstrated by combined phantom, pre-clinical and clinical PET/CT scans that PET acquisition overlap in axial of today’s systems can be reduced and optimized. It showed that a reduction of PET acquisition overlap to 27% (half of system default) can be implemented to reduce table time by ∼40% to improve patient comfort and minimize potential motion artifacts, without prominently degrading image quality or compromising PET quantification.« less

77 FR 58817 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0321... Financing AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice and... . Paper copies are available from Mr. Mark Gomersall, OUSD(AT&L) DPAP/DARS, Room 3B855, 3060 Defense...

76 FR 23504 - Defense Federal Acquisition Regulation Supplement; Definition of Multiple-Award Contract (DFARS...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 207 RIN 0750-AH12 Defense Federal Acquisition Regulation Supplement; Definition of Multiple-Award Contract (DFARS Case 2011-D016) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY...

78 FR 33994 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

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2013-06-06

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 252 RIN Number 0750-AG38 Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to Technical Data (DFARS 2009-D031); Correction AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD...

75 FR 40714 - Defense Federal Acquisition Regulation Supplement; Publication of Notification of Bundling of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-13

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75 FR 33752 - Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest in Major...

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2010-06-15

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76 FR 32843 - Defense Federal Acquisition Regulation Supplement; Fire-Resistant Fiber for Production of...

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2011-06-06

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78 FR 48397 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Transportation (DFARS...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 212, 216, 247, and 252...--Transportation (DFARS Case 2012-D057) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... manufacture, fabrication, or assembly by the Contractor or any subcontractor. (2) ``Department of Defense...

75 FR 75444 - Defense Federal Acquisition Regulation Supplement; Government Property (DFARS Case 2009-D008)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-03

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 201, 245, and 252 RIN...-D008) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Proposed... demilitarization shall be demilitarized by the Purchaser under the supervision of qualified Department of Defense...

77 FR 52254 - Defense Federal Acquisition Regulation Supplement: Reporting of Government-Furnished Property...

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2012-08-29

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 211, 212, and 252 RIN... (DFARS Case 2012-D001) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... requirements of the current clause, which requires Defense contractors to report (primarily) Government...

Synchronization of developmental processes and defense signaling by growth regulating transcription factors.

PubMed

Liu, Jinyi; Rice, J Hollis; Chen, Nana; Baum, Thomas J; Hewezi, Tarek

2014-01-01

Growth regulating factors (GRFs) are a conserved class of transcription factor in seed plants. GRFs are involved in various aspects of tissue differentiation and organ development. The implication of GRFs in biotic stress response has also been recently reported, suggesting a role of these transcription factors in coordinating the interaction between developmental processes and defense dynamics. However, the molecular mechanisms by which GRFs mediate the overlaps between defense signaling and developmental pathways are elusive. Here, we report large scale identification of putative target candidates of Arabidopsis GRF1 and GRF3 by comparing mRNA profiles of the grf1/grf2/grf3 triple mutant and those of the transgenic plants overexpressing miR396-resistant version of GRF1 or GRF3. We identified 1,098 and 600 genes as putative targets of GRF1 and GRF3, respectively. Functional classification of the potential target candidates revealed that GRF1 and GRF3 contribute to the regulation of various biological processes associated with defense response and disease resistance. GRF1 and GRF3 participate specifically in the regulation of defense-related transcription factors, cell-wall modifications, cytokinin biosynthesis and signaling, and secondary metabolites accumulation. GRF1 and GRF3 seem to fine-tune the crosstalk between miRNA signaling networks by regulating the expression of several miRNA target genes. In addition, our data suggest that GRF1 and GRF3 may function as negative regulators of gene expression through their association with other transcription factors. Collectively, our data provide new insights into how GRF1 and GRF3 might coordinate the interactions between defense signaling and plant growth and developmental pathways.

Detection thresholds for gaps, overlaps, and no-gap-no-overlaps.

PubMed

Heldner, Mattias

2011-07-01

Detection thresholds for gaps and overlaps, that is acoustic and perceived silences and stretches of overlapping speech in speaker changes, were determined. Subliminal gaps and overlaps were categorized as no-gap-no-overlaps. The established gap and overlap detection thresholds both corresponded to the duration of a long vowel, or about 120 ms. These detection thresholds are valuable for mapping the perceptual speaker change categories gaps, overlaps, and no-gap-no-overlaps into the acoustic domain. Furthermore, the detection thresholds allow generation and understanding of gaps, overlaps, and no-gap-no-overlaps in human-like spoken dialogue systems. © 2011 Acoustical Society of America

Systematic discovery of antiphage defense systems in the microbial pangenome.

PubMed

Doron, Shany; Melamed, Sarah; Ofir, Gal; Leavitt, Azita; Lopatina, Anna; Keren, Mai; Amitai, Gil; Sorek, Rotem

2018-03-02

The arms race between bacteria and phages led to the development of sophisticated antiphage defense systems, including CRISPR-Cas and restriction-modification systems. Evidence suggests that known and unknown defense systems are located in "defense islands" in microbial genomes. Here, we comprehensively characterized the bacterial defensive arsenal by examining gene families that are clustered next to known defense genes in prokaryotic genomes. Candidate defense systems were systematically engineered and validated in model bacteria for their antiphage activities. We report nine previously unknown antiphage systems and one antiplasmid system that are widespread in microbes and strongly protect against foreign invaders. These include systems that adopted components of the bacterial flagella and condensin complexes. Our data also suggest a common, ancient ancestry of innate immunity components shared between animals, plants, and bacteria. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 225 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System... Federal Acquisition Regulation Supplement (DFARS) to direct contracting officers to additional guidance on...

Acquisition Planning at the Defense Communications Agency.

DTIC Science & Technology

1984-04-01

guidelines for interaction are developed under the leadership of DCA agencywide integrators with the participation of personnel from DCA, the Services...Communications System DCSO - Defense Communications System Organizatin . DDN - Defense Data Network DEC - Decision Making DG - Defense Guidance DIA - Defense

76 FR 73602 - Privacy Act of 1974; System of Records

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2011-11-29

...; System of Records AGENCY: Defense Logistics Agency, Department of Defense (DoD). ACTION: Notice to amend a system of records. SUMMARY: The Defense Logistics Agency is proposing to amend a system of records...: Ms. Jody Sinkler, DLA FOIA/Privacy Act Office, Headquarters, Defense Logistics Agency, ATTN: DGA...

77 FR 76938 - Defense Federal Acquisition Regulation Supplement: Contracting Activity Updates (DFARS Case 2012...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 202 RIN 0750-AH81 Defense...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is... has either a significant effect beyond the internal operating procedures of the agency issuing the...

76 FR 71558 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Requests...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [Docket No. DARS 2011-0069-0002] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Requests for Equitable Adjustment (OMB Control Number 0704-0397) AGENCY: Defense Acquisition Regulations System, Department of...

Distinct Roles of Jasmonates and Aldehydes in Plant-Defense Responses

PubMed Central

Chehab, E. Wassim; Kaspi, Roy; Savchenko, Tatyana; Rowe, Heather; Negre-Zakharov, Florence; Kliebenstein, Dan; Dehesh, Katayoon

2008-01-01

Background Many inducible plant-defense responses are activated by jasmonates (JAs), C6-aldehydes, and their corresponding derivatives, produced by the two main competing branches of the oxylipin pathway, the allene oxide synthase (AOS) and hydroperoxide lyase (HPL) branches, respectively. In addition to competition for substrates, these branch-pathway-derived metabolites have substantial overlap in regulation of gene expression. Past experiments to define the role of C6-aldehydes in plant defense responses were biased towards the exogenous application of the synthetic metabolites or the use of genetic manipulation of HPL expression levels in plant genotypes with intact ability to produce the competing AOS-derived metabolites. To uncouple the roles of the C6-aldehydes and jasmonates in mediating direct and indirect plant-defense responses, we generated Arabidopsis genotypes lacking either one or both of these metabolites. These genotypes were subsequently challenged with a phloem-feeding insect (aphids: Myzus persicae), an insect herbivore (leafminers: Liriomyza trifolii), and two different necrotrophic fungal pathogens (Botrytis cinerea and Alternaria brassicicola). We also characterized the volatiles emitted by these plants upon aphid infestation or mechanical wounding and identified hexenyl acetate as the predominant compound in these volatile blends. Subsequently, we examined the signaling role of this compound in attracting the parasitoid wasp (Aphidius colemani), a natural enemy of aphids. Principal Findings This study conclusively establishes that jasmonates and C6-aldehydes play distinct roles in plant defense responses. The jasmonates are indispensable metabolites in mediating the activation of direct plant-defense responses, whereas the C6-aldehyes are not. On the other hand, hexenyl acetate, an acetylated C6-aldehyde, is the predominant wound-inducible volatile signal that mediates indirect defense responses by directing tritrophic (plant-herbivore-natural enemy) interactions. Significance The data suggest that jasmonates and hexenyl acetate play distinct roles in mediating direct and indirect plant-defense responses. The potential advantage of this “division of labor” is to ensure the most effective defense strategy that minimizes incurred damages at a reduced metabolic cost. PMID:18382679

78 FR 69076 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-18

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DoD-2013-OS-0216] Privacy Act of 1974; System of Records AGENCY: Defense Health Agency, DoD. ACTION: Notice to amend nineteen Record Systems..., Department of Defense. Defense Health Agency How Systems of Records Are Designated In the Department of...

76 FR 46756 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-03

...; System of Records AGENCY: Missile Defense Agency, Department of Defense (DoD). ACTION: Notice to Delete a System of Records. SUMMARY: The Missile Defense Agency proposes to delete a system of records notice in.... Peter Shearston, Missile Defense Agency, MDA/DXCM, 730 Irwin Ave, Schriever AFB, CO 80912-2101, or by...

78 FR 43866 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-22

... INFORMATION CONTACT or at the Defense Privacy and Civil Liberties Web site at http://dpclo.defense.gov/privacy... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DoD-2013-OS-0136] Privacy Act of 1974; System of Records AGENCY: Defense Information Systems Agency, DoD. ACTION: Notice to delete a System of...

Genome Dynamics and Evolution of the Mla (Powdery Mildew) Resistance Locus in BarleyW⃞

PubMed Central

Wei, Fusheng; Wing, Rod A.; Wise, Roger P.

2002-01-01

Genes that confer defense against pathogens often are clustered in the genome and evolve via diverse mechanisms. To evaluate the organization and content of a major defense gene complex in cereals, we determined the complete sequence of a 261-kb BAC contig from barley cv Morex that spans the Mla (powdery mildew) resistance locus. Among the 32 predicted genes on this contig, 15 are associated with plant defense responses; 6 of these are associated with defense responses to powdery mildew disease but function in different signaling pathways. The Mla region is organized as three gene-rich islands separated by two nested complexes of transposable elements and a 45-kb gene-poor region. A heterochromatic-like region is positioned directly proximal to Mla and is composed of a gene-poor core with 17 families of diverse tandem repeats that overlap a hypermethylated, but transcriptionally active, gene-dense island. Paleontology analysis of long terminal repeat retrotransposons indicates that the present Mla region evolved over a period of >7 million years through a variety of duplication, inversion, and transposon-insertion events. Sequence-based recombination estimates indicate that R genes positioned adjacent to nested long terminal repeat retrotransposons, such as Mla, do not favor recombination as a means of diversification. We present a model for the evolution of the Mla region that encompasses several emerging features of large cereal genomes. PMID:12172030

Parentage of overlapping offspring of an arboreal-breeding frog with no nest defense: implications for nest site selection and reproductive strategy.

PubMed

Tung, Wan-Ping; Chen, Yi-Huey; Cheng, Wei-Chun; Chuang, Ming-Feng; Hsu, Wan-Tso; Kam, Yeong-Choy; Lehtinen, Richard M

2015-01-01

Overlapping offspring occurs when eggs are laid in a nest containing offspring from earlier reproduction. Earlier studies showed that the parentage is not always obvious due to difficulties in field observation and/or alternative breeding tactics. To unveil the parentage between overlapping offspring and parents is critical in understanding oviposition site selection and the reproductive strategies of parents. Amplectant pairs of an arboreal-breeding frog, Kurixalus eiffingeri, lay eggs in tadpole-occupied nests where offspring of different life stages (embryos and tadpoles) coexist. We used five microsatellite DNA markers to assess the parentage between parents and overlapping offspring. We also tested the hypothesis that the male or female frog would breed in the same breeding site because of the scarcity of nest sites. Results showed varied parentage patterns, which may differ from the phenomenon of overlapping egg clutches reported earlier. Parentage analyses showed that only 58 and 25% of the tadpole-occupied stumps were reused by the same male and female respectively, partially confirming our prediction. Re-nesting by the same individual was more common in males than females, which is most likely related to the cost of tadpole feeding and/or feeding schemes of females. On the other hand, results of parentage analyses showed that about 42 and 75% of male and female respectively bred in tadpole-occupied stumps where tadpoles were genetically unrelated. Results of a nest-choice experiment revealed that 40% of frogs chose tadpole-occupied bamboo cups when we presented identical stumps, without or with tadpoles, suggesting that the habitat saturation hypothesis does not fully explain why frogs used the tadpole-occupied stumps. Several possible benefits of overlapping offspring with different life stages were proposed. Our study highlights the importance of integrating molecular data with field observations to better understand the reproductive biology and nest site selection of anuran amphibians.

77 FR 11367 - Defense Federal Acquisition Regulation Supplement; Extension of the Department of Defense Mentor...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 219 and Appendix I to Chapter 2 RIN 0750-AH59 Defense Federal Acquisition Regulation Supplement; Extension of the Department of... Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is issuing this final rule...

32 CFR 37.1025 - Must I report information to the Defense Assistance Awards Data System?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Must I report information to the Defense Assistance Awards Data System? 37.1025 Section 37.1025 National Defense Department of Defense OFFICE OF THE... Award Reporting Information About the Award § 37.1025 Must I report information to the Defense...

32 CFR 37.1025 - Must I report information to the Defense Assistance Awards Data System?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false Must I report information to the Defense Assistance Awards Data System? 37.1025 Section 37.1025 National Defense Department of Defense OFFICE OF THE... Award Reporting Information About the Award § 37.1025 Must I report information to the Defense...

32 CFR 37.1025 - Must I report information to the Defense Assistance Awards Data System?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Must I report information to the Defense Assistance Awards Data System? 37.1025 Section 37.1025 National Defense Department of Defense OFFICE OF THE... Award Reporting Information About the Award § 37.1025 Must I report information to the Defense...

32 CFR 37.1025 - Must I report information to the Defense Assistance Awards Data System?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Must I report information to the Defense Assistance Awards Data System? 37.1025 Section 37.1025 National Defense Department of Defense OFFICE OF THE... Award Reporting Information About the Award § 37.1025 Must I report information to the Defense...

32 CFR 37.1025 - Must I report information to the Defense Assistance Awards Data System?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Must I report information to the Defense Assistance Awards Data System? 37.1025 Section 37.1025 National Defense Department of Defense OFFICE OF THE... Award Reporting Information About the Award § 37.1025 Must I report information to the Defense...

Issues With Access to Acquisition Data and Information in the Department of Defense: Doing Data Right in Weapon System Acquisition

DTIC Science & Technology

2016-04-30

Defense: Doing Data Right in Weapon System Acquisition Nancy Moore, Senior Management Scientist, RAND Megan McKernan, Defense Research Analyst...Access to Acquisition Data & Information in the Department of Defense: Doing Data Right in Weapon System Acquisition Nancy Moore, Senior Management...With Access to Acquisition Data and Information in the Department of Defense: Doing Data Right in Weapon System Acquisition Nancy Y. Moore—is a

Overlapping buprenorphine, opioid, and benzodiazepine prescriptions among Veterans dually enrolled in VA and Medicare Part D

PubMed Central

Gellad, Walid F.; Zhao, Xinhua; Thorpe, Carolyn T.; Thorpe, Joshua M.; Sileanu, Florentina E.; Cashy, John P.; Mor, Maria; Hale, Jennifer A.; Radomski, Thomas; Hausmann, Leslie R. M.; Fine, Michael J.; Good, Chester B.

2016-01-01

Background Buprenorphine is a key tool in the management of opioid use disorder, but there are growing concerns about abuse, diversion and safety. These concerns are amplified for the Department of Veterans Affairs (VA), whose patients may receive care concurrently from multiple prescribers within and outside VA. To illustrate the extent of this challenge, we examined overlapping prescriptions for buprenorphine, opioids, and benzodiazepines among Veterans dually enrolled in VA and Medicare Part D. Methods We constructed a cohort of all Veterans dually enrolled in VA and Part D who filled an opioid prescription in 2012. We identified patients who received tablet or film buprenorphine products from either source. We calculated the proportion of buprenorphine recipients with any overlapping prescription (based on days supply) for a non-buprenorphine opioid or benzodiazepine, focusing on Veterans who received overlapping prescriptions from a different system than their buprenorphine prescription (Part D buprenorphine recipients receiving overlapping opioids or benzodiazepines from VA and vice versa). Results We identified 1,790 dually enrolled Veterans with buprenorphine prescriptions, including 760 (43%) from VA and 1,091 (61%) from Part D (61 Veterans with buprenorphine from both systems were included in each group). Among VA buprenorphine recipients, 199 (26%) received an overlapping opioid prescription and 11 (1%) received an overlapping benzodiazepine prescription from Part D. Among Part D buprenorphine recipients, 208 (19%) received an overlapping opioid prescription and 178 (16%) received an overlapping benzodiazepine prescription from VA. Among VA and Part D buprenorphine recipients with cross-system opioid overlap, 25% (49/199) and 35% (72/208), respectively, had >90 days of overlap. Conclusions Many buprenorphine recipients receive overlapping prescriptions for opioids and benzodiazepines from a different health care system than the one in which their buprenorphine was filled. These findings highlight a previously undocumented safety risk for Veterans dually enrolled in VA and Medicare. PMID:27925868

Overlapping buprenorphine, opioid, and benzodiazepine prescriptions among veterans dually enrolled in Department of Veterans Affairs and Medicare Part D.

PubMed

Gellad, Walid F; Zhao, Xinhua; Thorpe, Carolyn T; Thorpe, Joshua M; Sileanu, Florentina E; Cashy, John P; Mor, Maria; Hale, Jennifer A; Radomski, Thomas; Hausmann, Leslie R M; Fine, Michael J; Good, Chester B

2017-01-01

Buprenorphine is a key tool in the management of opioid use disorder, but there are growing concerns about abuse, diversion, and safety. These concerns are amplified for the Department of Veterans Affairs (VA), whose patients may receive care concurrently from multiple prescribers within and outside VA. To illustrate the extent of this challenge, we examined overlapping prescriptions for buprenorphine, opioids, and benzodiazepines among veterans dually enrolled in VA and Medicare Part D. We constructed a cohort of all veterans dually enrolled in VA and Part D who filled an opioid prescription in 2012. We identified patients who received tablet or film buprenorphine products from either source. We calculated the proportion of buprenorphine recipients with any overlapping prescription (based on days supply) for a nonbuprenorphine opioid or benzodiazepine, focusing on veterans who received overlapping prescriptions from a different system than their buprenorphine prescription (Part D buprenorphine recipients receiving overlapping opioids or benzodiazepines from VA and vice versa). There were 1790 dually enrolled veterans with buprenorphine prescriptions, including 760 (43%) from VA and 1091 (61%) from Part D (61 veterans with buprenorphine from both systems were included in each group). Among VA buprenorphine recipients, 199 (26%) received an overlapping opioid prescription and 11 (1%) received an overlapping benzodiazepine prescription from Part D. Among Part D buprenorphine recipients, 208 (19%) received an overlapping opioid prescription and 178 (16%) received an overlapping benzodiazepine prescription from VA. Among VA and Part D buprenorphine recipients with cross-system opioid overlap, 25% (49/199) and 35% (72/208), respectively, had >90 days of overlap. Many buprenorphine recipients receive overlapping prescriptions for opioids and benzodiazepines from a different health care system than the one in which their buprenorphine was filled. These findings highlight a previously undocumented safety risk for veterans dually enrolled in VA and Medicare.

Clinical, Cellular, and Molecular Aspects in the Pathophysiology of Rosacea

PubMed Central

Steinhoff, Martin; Buddenkotte, Jörg; Aubert, Jerome; Sulk, Mathias; Novak, Pawel; Schwab, Verena D.; Mess, Christian; Cevikbas, Ferda; Rivier, Michel; Carlavan, Isabelle; Déret, Sophie; Rosignoli, Carine; Metze, Dieter; Luger, Thomas A.; Voegel, Johannes J.

2013-01-01

Rosacea is a chronic inflammatory skin disease of unknown etiology. Although described centuries ago, the pathophysiology of this disease is still poorly understood. Epidemiological studies indicate a genetic component, but a rosacea gene has not been identified yet. Four subtypes and several variants of rosacea have been described. It is still unclear whether these subtypes represent a “developmental march” of different stages or are merely part of a syndrome that develops independently but overlaps clinically. Clinical and histopathological characteristics of rosacea make it a fascinating “human disease model” for learning about the connection between the cutaneous vascular, nervous, and immune systems. Innate immune mechanisms and dysregulation of the neurovascular system are involved in rosacea initiation and perpetuation, although the complex network of primary induction and secondary reaction of neuroimmune communication is still unclear. Later, rosacea may result in fibrotic facial changes, suggesting a strong connection between chronic inflammatory processes and skin fibrosis development. This review highlights recent molecular (gene array) and cellular findings and aims to integrate the different body defense mechanisms into a modern concept of rosacea pathophysiology. PMID:22076321

Study on combat effectiveness of air defense missile weapon system based on queuing theory

NASA Astrophysics Data System (ADS)

Zhao, Z. Q.; Hao, J. X.; Li, L. J.

2017-01-01

Queuing Theory is a method to analyze the combat effectiveness of air defense missile weapon system. The model of service probability based on the queuing theory was constructed, and applied to analyzing the combat effectiveness of "Sidewinder" and "Tor-M1" air defense missile weapon system. Finally aimed at different targets densities, the combat effectiveness of different combat units of two types' defense missile weapon system is calculated. This method can be used to analyze the usefulness of air defense missile weapon system.

77 FR 2653 - Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 212 and 252 RIN 0750-AH27 Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military-Purpose Nondevelopmental Items (DFARS Case 2011-D034) AGENCY: Defense Acquisition Regulations System...

Defenses and morality: Adam Smith, Sigmund Freud, and contemporary psychoanalysis.

PubMed

Gabrinetti, Paul A; Özler, Sule

2014-10-01

In this paper we follow the development and transmission of moral learning from Adam Smith's impartial spectator to Sigmund Freud's superego and then to contemporary psychoanalysis. We argue that defenses are an integral component in the acquisition of any moral system. Elaborating on this argument, we assert that there is a progression from defensive systems that are "closed" to defensive systems that are "open," as defined in a recent work by Novick and Novick. The former system is "static, avoids reality, and is characterized by power dynamics, sadomasochism, and omnipotent defense." The latter, on the other hand, is a system that allows for "joy, creativity, spontaneity, love and it is attuned to reality." Furthermore, while Smith and Freud's systems are more one-person systems of defense, contemporary psychoanalysis has moved to more of a two-person system.

Missile Defense: Ballistic Missile Defense System Testing Delays Affect Delivery of Capabilities

DTIC Science & Technology

2016-04-28

Page 1 GAO- 16 -339R Ballistic Missile Defense 441 G St. N.W. Washington, DC 20548 April 28, 2016 Congressional Committees Missile Defense...Ballistic Missile Defense System Testing Delays Affect Delivery of Capabilities For over half a century , the Department of Defense (DOD) has been...81, § 232 (a) (2011). 2 GAO- 16 -339R Ballistic Missile Defense baselines, we analyzed the testing goals for selected elements, which are

76 FR 63287 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-12

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DOD-2011-OS-0110] Privacy Act of 1974; System of Records AGENCY: Office of the Secretary of Defense, Department of Defense (DoD). ACTION: Notice..., Alternate OSD Federal Register Liaison Officer, Department of Defense. DHA 22 System name: Medical...

32 CFR 322.7 - Exempt systems of records.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Exempt systems of records. 322.7 Section 322.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.7 Exempt systems of...

32 CFR 322.7 - Exempt systems of records.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Exempt systems of records. 322.7 Section 322.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.7 Exempt systems of...

32 CFR 322.7 - Exempt systems of records.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Exempt systems of records. 322.7 Section 322.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.7 Exempt systems of...

32 CFR 322.7 - Exempt systems of records.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Exempt systems of records. 322.7 Section 322.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL SECURITY AGENCY/CENTRAL SECURITY SERVICES PRIVACY ACT PROGRAM § 322.7 Exempt systems of...

78 FR 33993 - Defense Federal Acquisition Regulation Supplement; Clarification of “F” Orders in the Procurement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-06

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 204 RIN 0750-AH80 Defense Federal Acquisition Regulation Supplement; Clarification of ``F'' Orders in the Procurement Instrument Identification Number Structure (DFARS Case 2012-D040); Correction AGENCY: Defense Acquisition Regulations System...

77 FR 35921 - Defense Federal Acquisition Regulation Supplement: Item Unique Identifier Update (DFARS Case 2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 211, 212, 218, 246, 252 and Appendix F to Chapter 2 RIN 0750-AH64 Defense Federal Acquisition Regulation Supplement: Item Unique Identifier Update (DFARS Case 2011-D055) AGENCY: Defense Acquisition Regulations System...

76 FR 6006 - Defense Federal Acquisition Regulation Supplement; Reporting of Government Property Lost, Stolen...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 245 and 252 [DFARS Case 2008-D049] RIN 0750-AG64 Defense Federal Acquisition Regulation Supplement; Reporting of Government Property Lost, Stolen, Damaged, or Destroyed AGENCY: Defense Acquisition Regulations System; Department of...

76 FR 21849 - Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card® and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 213 RIN 0750-AH07 Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card[supreg] and Aircraft Ground Services (DFARS Case 2009-D019) AGENCY: Defense Acquisition Regulations System, Department of...

76 FR 58149 - Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card® and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 213 RIN 0750-AH07 Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card[supreg] and Aircraft Ground Services (DFARS Case 2009-D019) AGENCY: Defense Acquisition Regulations System, Department of...

75 FR 20954 - Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest in Major...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 202, 203, 212, and 252 RIN 0750-AG63 Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest... System, Department of Defense (DoD). ACTION: Proposed rule with request for comments. SUMMARY: DoD is...

Clock Controller For Ac Self-Timing Analysis Of Logic System

DOEpatents

Lo, Tinchee; Flanagan, John D.

2004-05-18

A clock controller and clock generating method are provided for AC self-test timing analysis of a logic system. The controller includes latch circuitry which receives a DC input signal at a data input, and a pair of continuous out-of-phase clock signals at capture and launch clock inputs thereof. The latch circuitry outputs two overlapping pulses responsive to the DC input signal going high. The two overlapping pulses are provided to waveform shaper circuitry which produces therefrom two non-overlapping pulses at clock speed of the logic system to be tested. The two non-overlapping pulses are a single pair of clock pulses which facilitate AC self-test timing analysis of the logic system.

5 CFR 9901.404 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM...-for-performance evaluation system means the performance management system established under this...

32 CFR Appendix E to Part 310 - Sample of New or Altered System of Records Notice in Federal Register Format

Code of Federal Regulations, 2014 CFR

2014-07-01

... Notice in Federal Register Format E Appendix E to Part 310 National Defense Department of Defense... Format (See paragraph (f) of § 310.30) New system of records notice DEPARTMENT OF DEFENSE Office of the..., Department of Defense. NSLRB 01 System name: The National Security Labor Relations Board (NSLRB). System...

Prophage-mediated defense against viral attack and viral counter-defense

PubMed Central

Dedrick, Rebekah M.; Jacobs-Sera, Deborah; Guerrero Bustamante, Carlos A.; Garlena, Rebecca A.; Mavrich, Travis N.; Pope, Welkin H.; Reyes, Juan C Cervantes; Russell, Daniel A.; Adair, Tamarah; Alvey, Richard; Bonilla, J. Alfred; Bricker, Jerald S.; Brown, Bryony R.; Byrnes, Deanna; Cresawn, Steven G.; Davis, William B.; Dickson, Leon A.; Edgington, Nicholas P.; Findley, Ann M.; Golebiewska, Urszula; Grose, Julianne H.; Hayes, Cory F.; Hughes, Lee E.; Hutchison, Keith W.; Isern, Sharon; Johnson, Allison A.; Kenna, Margaret A.; Klyczek, Karen K.; Mageeney, Catherine M.; Michael, Scott F.; Molloy, Sally D.; Montgomery, Matthew T.; Neitzel, James; Page, Shallee T.; Pizzorno, Marie C.; Poxleitner, Marianne K.; Rinehart, Claire A.; Robinson, Courtney J.; Rubin, Michael R.; Teyim, Joseph N.; Vazquez, Edwin; Ware, Vassie C.; Washington, Jacqueline; Hatfull, Graham F.

2017-01-01

Temperate phages are common and prophages are abundant residents of sequenced bacterial genomes. Mycobacteriophages are viruses infecting mycobacterial hosts including Mycobacterium tuberculosis and Mycobacterium smegmatis, encompass substantial genetic diversity, and are commonly temperate. Characterization of ten Cluster N temperate mycobacteriophages reveals at least five distinct prophage-expressed viral defense systems that interfere with infection of lytic and temperate phages that are either closely-related (homotypic defense) or unrelated (heterotypic defense). Target specificity is unpredictable, ranging from a single target phage to one-third of those tested. The defense systems include a single-subunit restriction system, a heterotypic exclusion system, and a predicted (p)ppGpp synthetase, which blocks lytic phage growth, promotes bacterial survival, and enables efficient lysogeny. The predicted (p)ppGpp synthetase coded by the Phrann prophage defends against phage Tweety infection, but Tweety codes for a tetrapeptide repeat protein, gp54, that acts as a highly effective counter-defense system. Prophage-mediated viral defense offers an efficient mechanism for bacterial success in host-virus dynamics, and counter-defense promotes phage co-evolution. PMID:28067906

76 FR 79660 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

...; System of Records AGENCY: Defense Information Systems Agency, DoD. ACTION: Notice to delete a system of records. SUMMARY: The Defense Information Systems Agency is deleting one system of records notices in its...: Ms. Jeanette M. Weathers-Jenkins, Defense Information Systems Agency, 6916 Cooper Avenue, Fort Meade...

78 FR 52517 - Membership of the Performance Review Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-23

... Agency, Defense Contract Audit Agency, Defense Contract Management Agency, Defense Finance and Accounting Service, Defense Information Systems Agency, Defense Legal Services Agency, Defense Logistics Agency...

77 FR 49440 - Membership of the Performance Review Board

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-16

... Agency, Defense Contract Audit Agency, Defense Contract Management Agency, Defense Finance And Accounting Service, Defense Information Systems Agency, Defense Legal Services Agency, Defense Logistics Agency...

77 FR 40861 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-11

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2012-OS-0084] Privacy Act of 1974... Officer, Department of Defense. DHRA 10 DoD System name: Defense Sexual Assault Advocate Certification.... SUMMARY: The Office of the Secretary of Defense proposes to add a new system of records in its inventory...

76 FR 72689 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-25

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2011-OS-0131] Privacy Act of 1974; System of Records AGENCY: Office of the Secretary of Defense, Department of Defense (DoD). ACTION: Notice..., Alternate OSD Federal Register Liaison Officer, Department of Defense. DWHS E01 DoD System name: DoD Federal...

32 CFR 327.5 - Systems of records.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Systems of records. 327.5 Section 327.5 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM... disclosure within the Department of Defense (DoD). The contractor is considered the agent of DeCA and is to...

Strategic Defense Initiative: Splendid Defense or Pipe Dream? Headline Series No. 275.

ERIC Educational Resources Information Center

Armstrong, Scott; Grier, Peter

This pamphlet presents a discussion of the various components of President Reagan's Strategic Defense Initiative (SDI) including the problem of pulling together various new technologies into an effective defensive system and the politics of the so-called "star wars" system. An important part of the defense initiative is the…

32 CFR Appendix E to Part 247 - DoD Command Newspaper and Magazine Review System

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false DoD Command Newspaper and Magazine Review System E Appendix E to Part 247 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN...

32 CFR Appendix E to Part 247 - DoD Command Newspaper and Magazine Review System

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false DoD Command Newspaper and Magazine Review System E Appendix E to Part 247 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN...

32 CFR Appendix E to Part 247 - DoD Command Newspaper and Magazine Review System

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false DoD Command Newspaper and Magazine Review System E Appendix E to Part 247 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN...

32 CFR Appendix E to Part 247 - DoD Command Newspaper and Magazine Review System

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false DoD Command Newspaper and Magazine Review System E Appendix E to Part 247 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN...

Department of Defense (DOD) Automated Biometric Identification System (ABIS) Version 1.2: Initial Operational Test and Evaluation Report

DTIC Science & Technology

2015-05-01

Director, Operational Test and Evaluation Department of Defense (DOD) Automated Biometric Identification System (ABIS) Version 1.2 Initial...Operational Test and Evaluation Report May 2015 This report on the Department of Defense (DOD) Automated Biometric Identification System...COVERED - 4. TITLE AND SUBTITLE Department of Defense (DOD) Automated Biometric Identification System (ABIS) Version 1.2 Initial Operational Test

An Analysis of Turkey’s Defense Systems Acquisition Policy

DTIC Science & Technology

2009-03-01

i NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT An Analysis of Turkey’s Defense Systems Acquisition...2009 3. REPORT TYPE AND DATES COVERED MBA THESIS 4. TITLE AND SUBTITLE An Analysis of Turkey’s Defense Systems Acquisition Policy 6. AUTHOR(S...DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) The purpose of this MBA thesis is to analyze Turkey’s defense systems acquisition policy and

The Evolution of the Contract Type Used in Defense Acquisition with a Focus on Major Defense Weapon Systems

DTIC Science & Technology

2012-09-01

III. THE DEFENSE MARKETPLACE A. DEFENSE INDUSTRY OVERVIEW The market of the defense industry in the United States is different than the commercial...marketplace in a number of respects. Lorell, Lowell, Kennedy, and Levaux (2000) defined the uniqueness of the U.S. defense market in two ways. First...the U.S. defense market for weapon systems is characterized by a single buyer (Lorell et al., 2000, p. 13). “The second distinguishing feature of

5 CFR 9901.101 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... of Defense and the Director of the Office of Personnel Management (OPM). The Secretary may establish...

5 CFR 9901.101 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... of Defense and the Director of the Office of Personnel Management (OPM). The Secretary may establish...

77 FR 58816 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DoD-2012-OS-0094] Privacy Act of 1974; System of Records AGENCY: Defense Information Systems Agency, DoD. ACTION: Notice to delete five Systems of Records. SUMMARY: The Defense Information Systems Agency is deleting five systems of records...

Depth Perception and Defensive System Activation in a 3-D Environment

PubMed Central

Combe, Emmanuelle; Fujii, Naotaka

2011-01-01

To survive, animals must be able to react appropriately (in temporal and behavioral terms) when facing a threat. One of the essential parameters considered by the defensive system is the distance of the threat, the “defensive distance.” In this study, we investigate the visual depth cues that could be considered as an alarm cue for the activation of the defensive system. For this purpose, we performed an active-escape pain task in a virtual three-dimensional environment. In two experiments, we manipulated the nature and consistency of different depth cues: vergence, linear perspective, and angular size. By measuring skin conductance responses, we characterized the situations that activated the defensive system. We show that the angular size of the predator was sufficient information to trigger responses from the defensive system, but we also demonstrate that vergence, which can delay the emotional response in inconsistent situations, is also a highly reliable cue for the activation of the defensive system. PMID:21941515

Protecting Networks Via Automated Defense of Cyber Systems

DTIC Science & Technology

2016-09-01

autonomics, and artificial intelligence . Our conclusion is that automation is the future of cyber defense, and that advances are being made in each of...SUBJECT TERMS Internet of Things, autonomics, sensors, artificial intelligence , cyber defense, active cyber defense, automated indicator sharing...called Automated Defense of Cyber Systems, built upon three core technological components: sensors, autonomics, and artificial intelligence . Our

32 CFR Appendix C to Part 323 - Instructions for Preparation of Reports to New or Altered Systems

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Instructions for Preparation of Reports to New or Altered Systems C Appendix C to Part 323 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM Pt...

32 CFR Appendix C to Part 323 - Instructions for Preparation of Reports to New or Altered Systems

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Instructions for Preparation of Reports to New or Altered Systems C Appendix C to Part 323 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM Pt...

48 CFR 228.102-70 - Defense Environmental Restoration Program construction contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Restoration Program construction contracts. 228.102-70 Section 228.102-70 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.102-70 Defense Environmental Restoration Program construction contracts...

Sleeping tree selection of Cao Vit gibbon (Nomascus nasutus) living in degraded karst forest in Bangliang, Jingxi, China.

PubMed

Fei, Han-Lan; Scott, Matthew B; Zhang, Wen; Ma, Chang-Yong; Xiang, Zuo-Fu; Fan, Peng-Fei

2012-11-01

We studied the sleep-related behavior of two Cao Vit gibbon (Nomascus nasutus) groups in Bangliang Nature Reserve in Jingxi County, China between January 2008 and December 2009 to test four hypotheses related to sleeping tree selection (predation avoidance, thermoregulation, food access, and range defense). Gibbons entered sleeping trees 88 ± SD 37 min before sunset before their main potential nocturnal predator become active. They usually moved rapidly and straight to sleeping trees and kept silent once settled. Over the course of the study, gibbon groups used many (87 and 57 per group) sleeping trees and reused them irregularly. They also tended to sleep in relatively tall trees without lianas, choosing small branches close to the treetop. These behaviors would make it difficult for potential terrestrial predators to detect and approach the gibbons. Therefore, these results strongly support the predation avoidance hypothesis. Gibbons tended to sleep closer to ridges than to valley bottoms and they did not sleep at lower elevations in colder months. They thus appeared not to select sleeping trees to minimize thermoregulatory stress. Gibbons very rarely slept in feeding trees, instead generally sleeping more than 100 m away from the last feeding trees of the day or the first feeding tree of the next morning. These patterns led us to reject the food access hypothesis. Lastly, we did not find evidence to support the range defense hypothesis because gibbons did not sleep in overlap areas with neighbors more often than expected based on the proportion of overlap and exclusively used areas. © 2012 Wiley Periodicals, Inc.

75 FR 81247 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-27

... Control Records system of records is also covered by the Defense Finance and Accounting System T7330a... Defense Finance and Accounting System T7332, Defense Debt Management System (February 17, 2009, 74 FR 7665... of 1974; System of Records AGENCY: Office of the Secretary, DoD. ACTION: Notice to delete three...

32 CFR Appendix F to Part 286 - DoD Freedom of Information Act Program Components

Code of Federal Regulations, 2010 CFR

2010-07-01

... Defense Information Systems Agency Defense Contract Audit Agency Defense Intelligence Agency Defense Security Service Defense Logistics Agency National Imagery and Mapping Agency Defense Special Weapons Agency National Security Agency Office of the Inspector General, Department of Defense Defense Finance...

78 FR 35262 - Detection and Avoidance of Counterfeit Electronic Parts

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-12

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [DFARS Case 2012-D055] Detection and Avoidance of Counterfeit Electronic Parts AGENCY: Defense Acquisition Regulations System, Department of... detection and avoidance coverage proposed to be included in the Defense Federal Acquisition Regulation...

78 FR 27194 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-09

...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to delete a System of Records. SUMMARY: The Defense Finance and Accounting Service is deleting a system of records...: The Defense Finance and Accounting Service systems of records notices subject to the Privacy Act of...

77 FR 60400 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-03

...; System of Records AGENCY: Defense Finance and Accounting Service. ACTION: Notice to delete two systems of records. SUMMARY: The Defense Finance and Accounting Service is deleting two systems of records notices in.... SUPPLEMENTARY INFORMATION: The Defense Finance and Accounting Service systems of records notices subject to the...

78 FR 69392 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-19

...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to delete a system of records. SUMMARY: The Defense Finance and Accounting Service is deleting a system of records... INFORMATION: The Defense Finance and Accounting Service systems of records notices subject to the Privacy Act...

78 FR 6078 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to delete a system of records. SUMMARY: The Defense Finance and Accounting Service is deleting a system of records.... SUPPLEMENTARY INFORMATION: The Defense Finance and Accounting Service systems of records notices subject to the...

78 FR 27194 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-09

...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to delete two Systems of Records. SUMMARY: The Defense Finance and Accounting Service is deleting two systems of records...: The Defense Finance and Accounting Service systems of records notices subject to the Privacy Act of...

77 FR 65370 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-26

...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to delete a Systems of Records. SUMMARY: The Defense Finance and Accounting Service is deleting a system of records.... SUPPLEMENTARY INFORMATION: The Defense Finance and Accounting Service systems of records notices subject to the...

75 FR 17910 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

...; Systems of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to delete a system of records. SUMMARY: The Defense Logistics Agency proposes to delete a system of records notice in its existing...-5045. SUPPLEMENTARY INFORMATION: The Defense Logistics Agency systems of records notices subject to the...

75 FR 15694 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

...; Systems of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to delete a system of records. SUMMARY: The Defense Logistics Agency proposes to delete a system of records notice in its existing...-5045. SUPPLEMENTARY INFORMATION: The Defense Logistics Agency systems of records notices subject to the...

75 FR 33792 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... instructions for submitting comments. Mail: Federal Docket Management System Office, 1160 Defense Pentagon...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to add a system of records. SUMMARY: The Defense Intelligence proposes to add a system of records notice to its inventory of record...

75 FR 52515 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-26

...; System of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to alter a system of records. SUMMARY: The Defense Logistics Agency proposes to alter a system of records notice in its existing.... Jody Sinkler at (703) 767-5045. SUPPLEMENTARY INFORMATION: The Defense Logistics Agency systems of...

75 FR 19377 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

...; Systems of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to alter a system of records. SUMMARY: The Defense Logistics Agency proposes to alter a system of records notice in its existing...-5045. SUPPLEMENTARY INFORMATION: The Defense Logistics Agency systems of records notices subject to the...

75 FR 20580 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

...; Systems of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to amend a system of records. SUMMARY: The Defense Logistics Agency proposes to amend a system of records notice in its existing.... SUPPLEMENTARY INFORMATION: The Defense Logistics Agency systems of records notices subject to the Privacy Act of...

75 FR 10473 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

...; Systems of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to amend a system of records. SUMMARY: The Defense Logistics Agency proposes to amend a system of records notice in its existing...-5045. SUPPLEMENTARY INFORMATION: The Defense Logistics Agency systems of records notices subject to the...

76 FR 53420 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-26

...; Systems of Records AGENCY: Defense Logistics Agency, Department of Defense (DoD). ACTION: Notice to Delete a System of Records. SUMMARY: The Defense Logistics Agency proposes to delete a system of records... Docket Management System Office, 4800 Mark Center Drive, Suite 02G09, Alexandria, VA 22350-3100...

75 FR 17904 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to alter a system of records. Summary: The Defense Intelligence Agency is proposing to alter a system in its existing inventory of.... SUPPLEMENTARY INFORMATION: The Defense Intelligence Agency system of records notices subject to the Privacy Act...

75 FR 26201 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to amend a system of records. SUMMARY: The Defense Intelligence Agency is proposing to amend a system in its existing inventory of.... SUPPLEMENTARY INFORMATION: The Defense Intelligence Agency systems of records notices subject to the Privacy Act...

75 FR 30791 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-02

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to alter a system of records. SUMMARY: The Defense Intelligence Agency is proposing to alter a system of records in its existing... Lowery at (202) 231-1193. SUPPLEMENTARY INFORMATION: The Defense Intelligence Agency system of records...

77 FR 77047 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

...; System of Records AGENCY: Defense Contract Audit Agency, DoD. ACTION: Notice to delete a Systems of Records. SUMMARY: The Defense Contract Audit Agency (DCAA) is deleting a system of records in its existing... at (703) 767-1022. SUPPLEMENTARY INFORMATION: The Defense Contract Audit Agency (DCAA) systems of...

77 FR 77048 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

...; System of Records AGENCY: Defense Contract Audit Agency, DoD. ACTION: Notice to amend a System of Records. SUMMARY: The Defense Contract Audit Agency is amending a system of records notice in its existing.... SUPPLEMENTARY INFORMATION: The Defense Contract Audit Agency systems of records notices subject to the Privacy...

78 FR 27195 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-09

...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to delete two Systems of Records. SUMMARY: The Defense Finance and Accounting Service is deleting two systems of records...: The Defense Finance and Accounting Service systems of records notices subject to the Privacy Act of...

78 FR 31905 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-28

...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to amend a System of Records. SUMMARY: The Defense Finance and Accounting Service is amending a system of records...: The Defense Finance and Accounting Service systems of records notices subject to the Privacy Act of...

75 FR 21248 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-23

...; Systems of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to alter a system of records. SUMMARY: The Defense Finance and Accounting Service (DFAS) is proposing to alter a system...) 522-5225. SUPPLEMENTARY INFORMATION: The Defense Finance and Accounting Service notices for systems of...

75 FR 47797 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-09

... DEPARTMENT OF DEFENSE Defense Logistics Agency [Docket ID: DOD-2010-OS-0110] Privacy Act of 1974; System of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to delete a system of records. [[Page 47798

48 CFR 252.244-7001 - Contractor purchasing system administration.

Code of Federal Regulations, 2012 CFR

2012-10-01

... system administration. 252.244-7001 Section 252.244-7001 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... that materially affects the ability of officials of the Department of Defense to rely upon information...

48 CFR 252.244-7001 - Contractor purchasing system administration.

Code of Federal Regulations, 2011 CFR

2011-10-01

... system administration. 252.244-7001 Section 252.244-7001 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... that materially affects the ability of officials of the Department of Defense to rely upon information...

48 CFR 252.244-7001 - Contractor purchasing system administration.

Code of Federal Regulations, 2013 CFR

2013-10-01

... system administration. 252.244-7001 Section 252.244-7001 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... that materially affects the ability of officials of the Department of Defense to rely upon information...

48 CFR 245.7203 - Assigning plant clearance case numbers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Q—Navy E—Air Force L—Marine Corps U—Defense Logistics Agency N—Defense Nuclear Agency M—National... case numbers. 245.7203 Section 245.7203 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Special Instructions 245...

48 CFR 214.407-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Missile Defense Agency: General Counsel, MDA. (ix) Defense Contract Management Agency: General Counsel... before award. 214.407-3 Section 214.407-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of...

48 CFR 214.407-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Missile Defense Agency: General Counsel, MDA. (ix) Defense Contract Management Agency: General Counsel... before award. 214.407-3 Section 214.407-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of...

48 CFR 214.407-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) Missile Defense Agency: General Counsel, MDA. (ix) Defense Contract Management Agency: General Counsel... before award. 214.407-3 Section 214.407-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of...

48 CFR 214.407-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Missile Defense Agency: General Counsel, MDA. (ix) Defense Contract Management Agency: General Counsel... before award. 214.407-3 Section 214.407-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of...

48 CFR 214.407-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) Missile Defense Agency: General Counsel, MDA. (ix) Defense Contract Management Agency: General Counsel... before award. 214.407-3 Section 214.407-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of...

Why Innate Lymphoid Cells?

PubMed

Kotas, Maya E; Locksley, Richard M

2018-06-19

Innate lymphoid cells (ILCs) are positioned in tissues perinatally, constitutively express receptors responsive to their organ microenvironments, and perform an arsenal of effector functions that overlap those of adaptive CD4 + T cells. Based on knowledge regarding subsets of invariant-like lymphocytes (e.g., natural killer T [NKT] cells, γδ T cells, mucosal-associated invariant T [MAIT] cells, etc.) and fetally derived macrophages, we hypothesize that immune cells established during the perinatal period-including, but not limited to, ILCs-serve intimate roles in tissue that go beyond classical understanding of the immune system in microbial host defense. In this Perspective, we propose mechanisms by which the establishment of ILCs and the tissue lymphoid niche during early development may have consequences much later in life. Although definitive answers require better tools, efforts to achieve deeper understanding of ILC biology across the mammalian lifespan have the potential to lift the veil on the unknown breadth of immune cell functions. Copyright © 2018 Elsevier Inc. All rights reserved.

Shared signals and the potential for phylogenetic espionage between plants and animals.

PubMed

Schultz, Jack C

2002-07-01

Until recently, the study and understanding of plant and animal signalling and response mechanisms have developed independently. Recent biochemical and molecular work is producing a growing list of elements involved in responses to biotic and abiotic stimuli that are very similar across kingdoms. Some of the more interesting examples of these include prostaglandin/octadecanoid-mediated responses to wounding, steroid-based signalling systems, and pathogen-recognition mechanisms. Some of these similarities probably represent evolutionary convergence; others may be ancestral to plants and animals. Ecological and evolutionary implications of such overlaps include the existence of pathogens that can cause disease in plants and animals, the ability of herbivores to manipulate plant responses, usurpation of microbial mechanisms and genes by herbivorous animals and plants, evolution of plant defenses exploiting shared signals in animals, and the medicinal use of plants by humans. Comparative study of the signalling and response mechanisms used by plants, animals, and microbes provides novel and useful insights to the ecology and evolution of interactions across kingdoms.

Discrete Mathematical Approaches to Graph-Based Traffic Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joslyn, Cliff A.; Cowley, Wendy E.; Hogan, Emilie A.

2014-04-01

Modern cyber defense and anlaytics requires general, formal models of cyber systems. Multi-scale network models are prime candidates for such formalisms, using discrete mathematical methods based in hierarchically-structured directed multigraphs which also include rich sets of labels. An exemplar of an application of such an approach is traffic analysis, that is, observing and analyzing connections between clients, servers, hosts, and actors within IP networks, over time, to identify characteristic or suspicious patterns. Towards that end, NetFlow (or more generically, IPFLOW) data are available from routers and servers which summarize coherent groups of IP packets flowing through the network. In thismore » paper, we consider traffic analysis of Netflow using both basic graph statistics and two new mathematical measures involving labeled degree distributions and time interval overlap measures. We do all of this over the VAST test data set of 96M synthetic Netflow graph edges, against which we can identify characteristic patterns of simulated ground-truth network attacks.« less

32 CFR 1290.2 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS... Federal Magistrate System by DLA. This part 1290 is applicable to HQ DLA, Defense Supply Centers (DSC's), less Defense Fuel Supply Center and Defense Industrial Supply Center, and to Defense Depots, less...

32 CFR 1290.2 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-07-01

... National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS... Federal Magistrate System by DLA. This part 1290 is applicable to HQ DLA, Defense Supply Centers (DSC's), less Defense Fuel Supply Center and Defense Industrial Supply Center, and to Defense Depots, less...

32 CFR 1290.2 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-07-01

... National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS... Federal Magistrate System by DLA. This part 1290 is applicable to HQ DLA, Defense Supply Centers (DSC's), less Defense Fuel Supply Center and Defense Industrial Supply Center, and to Defense Depots, less...

32 CFR 1290.2 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-07-01

... National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS... Federal Magistrate System by DLA. This part 1290 is applicable to HQ DLA, Defense Supply Centers (DSC's), less Defense Fuel Supply Center and Defense Industrial Supply Center, and to Defense Depots, less...

32 CFR 1290.2 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-07-01

... National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS... Federal Magistrate System by DLA. This part 1290 is applicable to HQ DLA, Defense Supply Centers (DSC's), less Defense Fuel Supply Center and Defense Industrial Supply Center, and to Defense Depots, less...

The Jasmonate Pathway Is a Key Player in Systemically Induced Defense against Root Knot Nematodes in Rice1[C

PubMed Central

Nahar, Kamrun; Kyndt, Tina; De Vleesschauwer, David; Höfte, Monica; Gheysen, Godelieve

2011-01-01

Complex defense signaling pathways, controlled by different hormones, are involved in the reaction of plants to a wide range of biotic and abiotic stress factors. We studied the ability of salicylic acid, jasmonate (JA), and ethylene (ET) to induce systemic defense in rice (Oryza sativa) against the root knot nematode Meloidogyne graminicola. Exogenous ET (ethephon) and JA (methyl jasmonate) supply on the shoots induced a strong systemic defense response in the roots, exemplified by a major up-regulation of pathogenesis-related genes OsPR1a and OsPR1b, while the salicylic acid analog BTH (benzo-1,2,3-thiadiazole-7-carbothioic acid S-methyl ester) was a less potent systemic defense inducer from shoot to root. Experiments with JA biosynthesis mutants and ET-insensitive transgenics showed that ET-induced defense requires an intact JA pathway, while JA-induced defense was still functional when ET signaling was impaired. Pharmacological inhibition of JA and ET biosynthesis confirmed that JA biosynthesis is needed for ET-induced systemic defense, and quantitative real-time reverse transcription-polymerase chain reaction data revealed that ET application onto the shoots strongly activates JA biosynthesis and signaling genes in the roots. All data provided in this study point to the JA pathway to play a pivotal role in rice defense against root knot nematodes. The expression of defense-related genes was monitored in root galls caused by M. graminicola. Different analyzed defense genes were attenuated in root galls caused by the nematode at early time points after infection. However, when the exogenous defense inducers ethephon and methyl jasmonate were supplied to the plant, the nematode was less effective in counteracting root defense pathways, hence making the plant more resistant to nematode infection. PMID:21715672

77 FR 69444 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-19

..., Defense Finance and Accounting Service, Freedom of Information/Privacy Act Program Manager, Corporate...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to amend a system of records. SUMMARY: The Defense Finance and Accounting Service is amending a system of records...

78 FR 41917 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-12

...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to amend a System of Records. SUMMARY: The Defense Finance and Accounting Service is amending a system of records...: Mr. Gregory Outlaw, (317) 510-4591. SUPPLEMENTARY INFORMATION: The Defense Finance and Accounting...

32 CFR 637.20 - Security surveillance systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 4 2011-07-01 2011-07-01 false Security surveillance systems. 637.20 Section 637.20 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW... surveillance systems. Closed circuit video recording systems, to include those with an audio capability, may be...

32 CFR 637.20 - Security surveillance systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 4 2012-07-01 2011-07-01 true Security surveillance systems. 637.20 Section 637.20 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW... surveillance systems. Closed circuit video recording systems, to include those with an audio capability, may be...

32 CFR 637.20 - Security surveillance systems.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 4 2014-07-01 2013-07-01 true Security surveillance systems. 637.20 Section 637.20 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW... surveillance systems. Closed circuit video recording systems, to include those with an audio capability, may be...

32 CFR 637.20 - Security surveillance systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 4 2013-07-01 2013-07-01 false Security surveillance systems. 637.20 Section 637.20 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW... surveillance systems. Closed circuit video recording systems, to include those with an audio capability, may be...

Secured network sensor-based defense system

NASA Astrophysics Data System (ADS)

Wei, Sixiao; Shen, Dan; Ge, Linqiang; Yu, Wei; Blasch, Erik P.; Pham, Khanh D.; Chen, Genshe

2015-05-01

Network sensor-based defense (NSD) systems have been widely used to defend against cyber threats. Nonetheless, if the adversary finds ways to identify the location of monitor sensors, the effectiveness of NSD systems can be reduced. In this paper, we propose both temporal and spatial perturbation based defense mechanisms to secure NSD systems and make the monitor sensor invisible to the adversary. The temporal-perturbation based defense manipulates the timing information of published data so that the probability of successfully recognizing monitor sensors can be reduced. The spatial-perturbation based defense dynamically redeploys monitor sensors in the network so that the adversary cannot obtain the complete information to recognize all of the monitor sensors. We carried out experiments using real-world traffic traces to evaluate the effectiveness of our proposed defense mechanisms. Our data shows that our proposed defense mechanisms can reduce the attack accuracy of recognizing detection sensors.

5 CFR 9901.401 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... between the performance management system and DoD's strategic plan; (4) A means for ensuring employee... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM...

5 CFR 9901.401 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-01-01

... between the performance management system and DoD's strategic plan; (4) A means for ensuring employee... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM...

75 FR 81247 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-27

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to delete a system of records. SUMMARY: The Defense Intelligence Agency proposes to delete a system of records notice in its existing... Defense Intelligence Agency systems of records notices subject to the Privacy Act of 1974, (5 U.S.C. 552a...

75 FR 13089 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

...; Systems of Records AGENCY: Defense Intelligence Agency, (DoD). ACTION: Notice to amend a system of records. SUMMARY: The Defense Intelligence Agency proposes to amend a system of records notice of its inventory of... INFORMATION: The Defense Intelligence Agency notices for systems of records subject to the Privacy Act of 1974...

77 FR 26260 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to Delete a System of Records. SUMMARY: The Defense Intelligence Agency proposes to delete a system of records notice in its existing...: The Defense Intelligence Agency systems of records notices subject to the Privacy Act of 1974 (5 U.S.C...

76 FR 10010 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-23

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to Delete a System of Records. SUMMARY: The Defense Intelligence Agency proposes to delete a system of records notice in its existing... Defense Intelligence Agency systems of records notices subject to the Privacy Act of 1974, (5 U.S.C. 552a...

75 FR 33791 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to add a system of records. SUMMARY: The Defense Intelligence Agency proposes to add a system of records to its inventory of record...: The Defense Intelligence Agency systems of records notices subject to the Privacy Act of 1974, (5 U.S...

78 FR 14282 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-05

...; System of Records AGENCY: Defense Contract Audit Agency, DoD. ACTION: Notice to alter a System of Records. SUMMARY: The Defense Contract Audit Agency proposes to alter a system of records in its inventory of.... SUPPLEMENTARY INFORMATION: The Defense Contract Audit Agency notices for systems of records subject to the...

76 FR 115 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-03

...; System of Records AGENCY: Defense Contract Audit Agency, DoD. ACTION: Notice to amend a system of records. SUMMARY: The Defense Contract Audit Agency is proposing to amend a system of records notice in its... INFORMATION: The Defense Contract Audit Agency systems of records notices subject to the Privacy Act of 1974...

76 FR 114 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-03

...; System of Records AGENCY: Defense Contract Audit Agency, DoD. ACTION: Notice to amend a system of records. SUMMARY: The Defense Contract Audit Agency is proposing to amend a system of records notice in its... INFORMATION: The Defense Contract Audit Agency systems of records notices subject to the Privacy Act of 1974...

78 FR 14284 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-05

...; System of Records AGENCY: Defense Contract Audit Agency, DoD. ACTION: Notice to alter a System of Records. SUMMARY: The Defense Contract Audit Agency proposes to alter a system of records in its inventory of.... SUPPLEMENTARY INFORMATION: The Defense Contract Audit Agency notices for systems of records subject to the...

78 FR 47309 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-05

...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to amend a System of Records. SUMMARY: The Defense Finance and Accounting Service proposes to alter a system of records... Defense Finance and Accounting Service systems of records notices subject to the Privacy Act of 1974 (5 U...

75 FR 33788 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... Allard at (703) 588-6830. SUPPLEMENTARY INFORMATION: The Office of the Secretary of Defense systems of...; System of Records AGENCY: Department of Defense, DoD. ACTION: Notice to delete a system of records. SUMMARY: The Office of the Secretary of Defense proposes to delete a systems of record notice from its...

77 FR 25991 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

... DEPARTMENT OF DEFENSE Department of the Army [Docket ID: USA-2012-0008] Privacy Act of 1974; System of Records AGENCY: Defense Information Systems Agency, DoD. ACTION: Notice to Add a New System of... Federal Register Liaison Officer, Department of Defense. A0350-1 ARNG System name: Guard University (Guard...

75 FR 76430 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-08

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DOD-2010-OS-0159] Privacy Act of 1974.... Park, Alternate OSD Federal Register Liaison Officer, Department of Defense. DWHS P37 * * * * * SYSTEM... Headquarters Services, Department of Defense, 1155 Defense Pentagon, Washington, DC 20301-1155.'' CATEGORIES OF...

76 FR 58788 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-22

... Manager, Corporate Communications, Defense Finance and Accounting Service, DFAS-HKC/IN, 8899 E. 56th... inquires to FOIA/PA Program Manager, Corporate Communications, Defense Finance and Accounting Service, DFAS...; Systems of Records AGENCY: Defense Finance and Accounting Service, Department of Defense, (DoD). ACTION...

5 CFR 9901.341 - General.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... supports mission accomplishment. ...

5 CFR 9901.341 - General.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... supports mission accomplishment. ...

Defense Enterprise Accounting and Management System-Increment 1 (DEAMS Inc 1)

DTIC Science & Technology

2016-03-01

information accurately and in conformance with Generally Accepted Accounting Principles , to comply with Congressional requirements of the Chief Financial ...2016 Major Automated Information System Annual Report Defense Enterprise Accounting and Management System-Increment 1 (DEAMS Inc 1) Defense...Phone: 937-257-2714 Fax: DSN Phone: 787-2714 DSN Fax: Date Assigned: August 17, 2015 Program Information Program Name Defense Enterprise Accounting

32 CFR 634.44 - The traffic point system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true The traffic point system. 634.44 Section 634.44 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND... § 634.44 The traffic point system. The traffic point system provides a uniform administrative device to...

75 FR 61450 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

..., Corporate Communications, Defense Finance and Accounting Service, DFAS-HKC/IN, 8899 E. 56th Avenue...; System of Records AGENCY: Defense Finance and Accounting Service; DoD. ACTION: Notice to add a system of records. SUMMARY: The Defense Finance and Accounting Service (DFAS) is proposing to add a system of...

75 FR 36640 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-28

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2010-OS-0085] Privacy Act of 1974; System of Records AGENCY: Department of Defense (DoD). ACTION: Notice to alter a system of records... Liaison Officer, Department of Defense. DWHS D01 System name: Pentagon Parking/national Capital Region...

75 FR 63160 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-14

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DOD-2010-OS-0142] Privacy Act of 1974; System of Records AGENCY: Department of Defense (DoD). ACTION: Notice to alter a system of records... Federal Register Liaison Officer, Department of Defense. DWHS E05 System name: Mandatory Declassification...

78 FR 6077 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DoD-2013-OS-0009] Privacy Act of 1974; System of Records AGENCY: Defense Security Service, DoD. ACTION: Notice to amend a System of Records... OSD Federal Register Liaison Officer, Department of Defense. V5-04 System name: Counterintelligence...

77 FR 34357 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2012-OS-0062] Privacy Act of 1974; System of Records AGENCY: Defense Information Systems Agency, DoD. ACTION: Notice to alter a system of..., 2012. Aaron Siegel, Alternate OSD Federal Register Liaison Officer, Department of Defense. K890.01...

32 CFR 635.27 - Vehicle Registration System.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Vehicle Registration System. 635.27 Section 635.27 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Offense Reporting § 635.27 Vehicle Registration System. The Vehicle Registration System (VR...

32 CFR 310.32 - System notices.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Publication Requirements § 310.32 System notices. (a) Contents of the system... database or the IT system if the name does not meet the criteria in paragraph (c)(1) of this section. (d...

32 CFR 310.32 - System notices.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Publication Requirements § 310.32 System notices. (a) Contents of the system... database or the IT system if the name does not meet the criteria in paragraph (c)(1) of this section. (d...

32 CFR 310.32 - System notices.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Publication Requirements § 310.32 System notices. (a) Contents of the system... database or the IT system if the name does not meet the criteria in paragraph (c)(1) of this section. (d...

76 FR 24000 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

...; Systems of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to add a system of records. SUMMARY: The Defense Logistics Agency proposes to add a system of records notice to its existing inventory... Act Officer, Headquarters, Defense Logistics Agency, Attn: DGA, 8725 John J. Kingman Road, Stop 16443...

76 FR 20339 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

...; Systems of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to Alter a System of Records. SUMMARY: The Defense Logistics Agency proposes to alter a system of records notice in its existing... Officer, Headquarters, Defense Logistics Agency, Attn: DGA, 8725 John J. Kingman Road, Stop 16443, Fort...

77 FR 26258 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to Alter a System of Records. SUMMARY: The Defense Intelligence Agency is proposing to alter a system to its existing inventory of... identifiers or contact information. FOR FURTHER INFORMATION CONTACT: Ms. Theresa Lowery, Defense Intelligence...

78 FR 47308 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-05

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to alter a System of Records. SUMMARY: The Defense Intelligence Agency is proposing to alter a system of records in its existing.... FOR FURTHER INFORMATION CONTACT: Ms. Theresa Lowery at Defense Intelligence Agency, DAN 1-C, 600...

78 FR 22524 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-16

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to alter a System of Records. SUMMARY: The Defense Intelligence Agency is proposing to alter a system to its existing inventory of.... FOR FURTHER INFORMATION CONTACT: Ms. Theresa Lowery at Defense Intelligence Agency, DAN 1-C, 600...

76 FR 35191 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-16

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to alter a system of records. SUMMARY: The Defense Intelligence Agency is proposing to alter a system to its existing inventory of...: Ms. Theresa Lowery, Defense Intelligence Agency, DAN 1-C, 600 McDill Blvd., Washington, DC 20340...

77 FR 57077 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-17

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to Add a System of Records. SUMMARY: The Defense Intelligence Agency is proposing the add a system to its existing inventory of... information. FOR FURTHER INFORMATION CONTACT: Ms. Theresa Lowery at Defense Intelligence Agency, DAN 1-C, 600...

77 FR 26262 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to alter a system of records. SUMMARY: The Defense Intelligence Agency is proposing to alter a system to its existing inventory of.... FOR FURTHER INFORMATION CONTACT: Ms. Theresa Lowery. Defense Intelligence Agency, DAN 1-C, 600 McDill...

78 FR 5787 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-28

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to alter a System of Records. SUMMARY: The Defense Intelligence Agency is proposing to alter a system to its existing inventory of.... FOR FURTHER INFORMATION CONTACT: Ms. Theresa Lowery at Defense Intelligence Agency, DAN 1-C, 600...

77 FR 26256 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to Alter a System of Records. SUMMARY: The Defense Intelligence Agency is proposing to alter a system to its existing inventory of.... FOR FURTHER INFORMATION CONTACT: Ms. Theresa Lowery, Defense Intelligence Agency, DAN 1-C, 600 McDill...

78 FR 41916 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-12

... Defense Finance and Accounting Service, Freedom of Information/Privacy Act Program Manager, Corporate...; System of Records AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice to alter a System of Records. SUMMARY: The Defense Finance and Accounting Service proposes to alter a system of records...

76 FR 52322 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

...; System of Records AGENCY: Office of the Secretary of Defense, Department of Defense (DoD). ACTION: Notice to delete a System of Records. SUMMARY: The Office of the Secretary of Defense (Office of Assistant General Counsel, Manpower and Health Affairs) is deleting systems of records notice from its existing...

75 FR 32416 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2010-OS-0075] Privacy Act of 1974; System of Records AGENCY: Department of Defense (DoD). ACTION: Notice to amend a system of records.... Mitchell S. Bryman, Alternate OSD Federal Register Liaison Officer, Department of Defense. WUSU 07 System...

77 FR 26261 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

...; System of Records AGENCY: Office of the Defense Logistics Agency, DoD. ACTION: Notice to alter a system of records. SUMMARY: The Defense Logistics Agency proposes to alter a system of records in its.../Privacy Act Office, Headquarters, Defense Logistics Agency, ATTN: DGA, 8725 John J. Kingman Road, Suite...

32 CFR 701.129 - Exemptions for specific Marine Corps record systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Exemptions for specific Marine Corps record systems. 701.129 Section 701.129 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY... Exemptions for specific Marine Corps record systems. (a) [Reserved] (b) System identifier and name: (1...

32 CFR 701.129 - Exemptions for specific Marine Corps record systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Exemptions for specific Marine Corps record systems. 701.129 Section 701.129 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY... Exemptions for specific Marine Corps record systems. (a) [Reserved] (b) System identifier and name: (1...

76 FR 20341 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

...; Systems of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to alter a system of records. SUMMARY: The Defense Logistics Agency proposes to alter a system of records notice in its existing... Officer, Headquarters, Defense Logistics Agency, Attn: DGA, 8725 John J. Kingman Road, Stop 16443, Fort...

76 FR 12078 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-04

...; Systems of Records AGENCY: Defense Logistics Agency. ACTION: Notice to alter a system of records. SUMMARY: The Defense Logistics Agency proposes to alter a system of records notice in its existing inventory of... Act Officer, Headquarters, Defense Logistics Agency, Attn: DGA, 8725 John J. Kingman Road, Stop 16443...

76 FR 13991 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-15

...; System of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to amend a system of records. SUMMARY: The Defense Logistics Agency is proposing to amend a system of records notice in its existing...-5045, or the Privacy Act Officer, Headquarters Defense Logistics Agency, ATTN: DGA, 8725 John J...

76 FR 28002 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-13

...; Systems of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to delete three systems of records. SUMMARY: The Defense Logistics Agency proposes to delete three systems of records notices in its..., Headquarters Defense Logistics Agency, ATTN: DGA, 8725 John J. Kingman Road, Suite 1644, Fort Belvoir, VA 22060...

76 FR 12076 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-04

...; System of Records AGENCY: Defense Logistics Agency, DoD. ACTION: Notice to amend a system of records. SUMMARY: The Defense Logistics Agency is proposing to amend a system of records notice in its existing...-5045, or Privacy Act Officer, Headquarters Defense Logistics Agency, ATTN: DGA, 8725 John J. Kingman...

Idiopathic inflammatory myopathies overlapping with systemic diseases

PubMed Central

Lepreux, Sébastien; Hainfellner, Johannes A.; Vital, Anne

2018-01-01

A muscle biopsy is currently requested to assess the diagnosis of an idiopathic inflammatory myopathy overlapping with a systemic disease. During the past few years, the classification of inflammatory myopathy subtypes has been revisited progressively on the basis of correlations between clinical phenotypes, autoantibodies and histological data. Several syndromic entities are now more clearly defined, and the aim of the present review is to clarify the contribution of muscle biopsy in a setting of idiopathic inflammatory myopathies overlapping with systemic diseases. PMID:29154752

75 FR 78619 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 216 and 237 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations... the Defense Federal Acquisition Regulation Supplement (DFARS) to set forth references to supplementary...

Sandia National Laboratories: National Security Missions: Defense Systems

Science.gov Websites

; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

Communication Avoiding and Overlapping for Numerical Linear Algebra

DTIC Science & Technology

2012-05-08

future exascale systems, communication cost must be avoided or overlapped. Communication-avoiding 2.5D algorithms improve scalability by reducing...linear algebra problems to future exascale systems, communication cost must be avoided or overlapped. Communication-avoiding 2.5D algorithms improve...will continue to grow relative to the cost of computation. With exascale computing as the long-term goal, the community needs to develop techniques

78 FR 19467 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-01

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [Docket Number DARS-2013-0010... Mentor-Prot[eacute]g[eacute] Program AGENCY: Defense Acquisition Regulations System, Department of... Collection DFARS Appendix I-112.2(a)-(d) requires mentor firms to report on the progress made under active...

Medical isotope identification with large mobile detection systems

NASA Astrophysics Data System (ADS)

Mukhopadhyay, Sanjoy; Maurer, Richard

2012-10-01

The Remote Sensing laboratory (RSL) of National Security Technologies Inc. has built an array of large (5.08 - cm x 10.16 - cm x 40.6 - cm) thallium doped sodium iodide (NaI: Tl) scintillators to locate and screen gamma-ray emitting radioisotopes that are of interests to radiological emergency responders [1]. These vehicle mounted detectors provide the operators with rapid, simple, specific information for radiological threat assessment. Applications include large area inspection, customs inspection, border protection, emergency response, and monitoring of radiological facilities. These RSL mobile units are currently being upgraded to meet the Defense Threat Reduction Agency mission requirements for a next-generation system capable of detecting and identifying nuclear threat materials. One of the challenging problems faced by these gamma-ray detectors is the unambiguous identification of medical isotopes like 131I (364.49 keV [81.7%], 636.99 keV [7.17%]), 99Tcm (140.51 keV [89.1%]) and 67Ga (184.6 keV [19.7%], 300.2 [16.0%], 393.5 [4.5%] that are used in radionuclide therapy and often have overlapping gamma-ray energy regions of interest (ROI). The problem is made worse by short (about 5 seconds) acquisition time of the spectral data necessary for dynamic mobile detectors. This article describes attempts to identify medical isotopes from data collected from this mobile detection system in a short period of time (not exceeding 5 secs) and a large standoff distance (typically 10 meters) The mobile units offer identification capabilities that are based on hardware auto stabilization of the amplifier gain. The 1461 keV gamma-energy line from 40K is tracked. It uses gamma-ray energy windowing along with embedded mobile Gamma Detector Response and Analysis Software (GADRAS) [2] simultaneously to deconvolve any overlapping gamma-energy ROIs. These high sensitivity detectors are capable of resolving complex masking scenarios and exceed all ANSI N42.34 (2006) requirements for the identification of bare, shielded and multiple isotopes.

Phase-space overlap measures. I. Fail-safe bias detection in free energies calculated by molecular simulation

NASA Astrophysics Data System (ADS)

Wu, Di; Kofke, David A.

2005-08-01

We consider ways to quantify the overlap of the parts of phase space important to two systems, labeled A and B. Of interest is how much of the A-important phase space lies in that important to B, and how much of B lies in A. Two measures are proposed. The first considers four total-energy distributions, formed from all combinations made by tabulating either the A-system or the B-system energy when sampling either the A or B system. Measures for A in B and B in A are given by two overlap integrals defined on pairs of these distributions. The second measure is based on information theory, and defines two relative entropies which are conveniently expressed in terms of the dissipated work for free-energy perturbation (FEP) calculations in the A →B and B →A directions, respectively. Phase-space overlap is an important consideration in the performance of free-energy calculations. To demonstrate this connection, we examine bias in FEP calculations applied to a system of independent particles in a harmonic potential. Systems are selected to represent a range of overlap situations, including extreme subset, subset, partial overlap, and nonoverlap. The magnitude and symmetry of the bias (A →B vs B →A) are shown to correlate well with the overlap, and consequently with the overlap measures. The relative entropies are used to scale the amount of sampling to obtain a universal bias curve. This result leads to develop a simple heuristic that can be applied to determine whether a work-based free-energy measurement is free of bias. The heuristic is based in part on the measured free energy, but we argue that it is fail-safe inasmuch as any bias in the measurement will not promote a false indication of accuracy.

The Science and Technology of the US National Missile Defense System

NASA Astrophysics Data System (ADS)

Postol, Theodore A.

2010-03-01

The National Missile Defense System utilizes UHF and X-band radars for search, track and discrimination, and interceptors that use long-wave infrared sensors to identify and home on attacking warheads. The radars and infrared sensors in the missile defense system perform at near the theoretical limits predicted by physics. However, in spite of the fantastic technical advances in sensor technology, signal processing, and computational support functions, the National Missile Defense System cannot be expected to ever work in realistic combat environments. This talk will describe why these impressive technologies can never deliver on the promise of a credible defense against long-range ballistic missiles.

48 CFR 211.002 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DEFENSE ACQUISITION PLANNING DESCRIBING AGENCY NEEDS 211.002 Policy. All defense technology and... System, and DoDI 5000.2, Operation of the Defense Acquisition System. [71 FR 27641, May 12, 2006] ...

78 FR 15711 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-12

... use to determine if contractor material management and accounting systems conform to established DoD... DEPARTMENT OF DEFENSE Defense Acquisition Regulation System [Docket No. 2012-0044-0001] Submission for OMB Review; Comment Request ACTION: Notice. The Defense Acquisition Regulations System has...

Component Composition for Embedded Systems Using Semantic Aspect-Oriented Programming

DTIC Science & Technology

2004-10-01

real - time systems for the defense community. Our research focused on Real-Time Java implementation and analysis techniques. Real-Time Java is important for the defense community because it holds out the promise of enabling developers to apply COTS Java technology to specialized military embedded systems. It also promises to allow the defense community to utilize a large Java-literate workforce for building defense systems. Our research has delivered several techniques that may make Real-Time Java a better platform for developing embedded

Defense Logistics Agency Did Not Obtain Fair and Reasonable Prices From Meggitt Aircraft Braking Systems for Sole-Source Commercial Spare Parts (REDACTED)

DTIC Science & Technology

2015-05-08

Defense Logistics Agency Did Not Obtain Fair and Reasonable Prices From Meggitt Aircraft Braking Systems for Sole-Source Commercial Spare Parts...Defense Logistics Agency Did Not Obtain Fair and Reasonable Prices From Meggitt Aircraft Braking Systems for Sole-Source Commercial Spare Parts...D000AH-0180.000) │ i Results in Brief Defense Logistics Agency Did Not Obtain Fair and Reasonable Prices From Meggitt Aircraft Braking Systems for

Density-dependent adjustment of inducible defenses.

PubMed

Tollrian, Ralph; Duggen, Sonja; Weiss, Linda C; Laforsch, Christian; Kopp, Michael

2015-08-03

Predation is a major factor driving evolution, and organisms have evolved adaptations increasing their survival chances. However, most defenses incur trade-offs between benefits and costs. Many organisms save costs by employing inducible defenses as responses to fluctuating predation risk. The level of defense often increases with predator densities. However, individual predation risk should not only depend on predator density but also on the density of conspecifics. If the predator has a saturating functional response one would predict a negative correlation between prey density and individual predation risk and hence defense expression. Here, we tested this hypothesis using six model systems, covering a taxonomic range from protozoa to rotifers and crustaceans. In all six systems, we found that the level of defense expression increased with predator density but decreased with prey density. In one of our systems, i.e. in Daphnia, we further show that the response to prey density is triggered by a chemical cue released by conspecifics and congeners. Our results indicate that organisms adjust the degree of defense to the acute predation risk, rather than merely to predators' densities. Our study suggests that density-dependent defense expression reflects accurate predation-risk assessment and is a general principle in many inducible-defense systems.

Density-dependent adjustment of inducible defenses

PubMed Central

Tollrian, Ralph; Duggen, Sonja; Weiss, Linda C.; Laforsch, Christian; Kopp, Michael

2015-01-01

Predation is a major factor driving evolution, and organisms have evolved adaptations increasing their survival chances. However, most defenses incur trade-offs between benefits and costs. Many organisms save costs by employing inducible defenses as responses to fluctuating predation risk. The level of defense often increases with predator densities. However, individual predation risk should not only depend on predator density but also on the density of conspecifics. If the predator has a saturating functional response one would predict a negative correlation between prey density and individual predation risk and hence defense expression. Here, we tested this hypothesis using six model systems, covering a taxonomic range from protozoa to rotifers and crustaceans. In all six systems, we found that the level of defense expression increased with predator density but decreased with prey density. In one of our systems, i.e. in Daphnia, we further show that the response to prey density is triggered by a chemical cue released by conspecifics and congeners. Our results indicate that organisms adjust the degree of defense to the acute predation risk, rather than merely to predators’ densities. Our study suggests that density-dependent defense expression reflects accurate predation-risk assessment and is a general principle in many inducible-defense systems. PMID:26235428

75 FR 16758 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

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77 FR 75621 - Privacy Act of 1974; System of Records

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76 FR 26714 - Privacy Act of 1974; Systems of Records

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76 FR 11213 - Privacy Act of 1974; Systems of Records

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75 FR 59102 - Defense Federal Acquisition Regulation Supplement; Part 204, Administrative Matters

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... indexing methodology across DoD. This technical amendment adds language to the Defense Federal Acquisition... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 204 Defense Federal Acquisition Regulation Supplement; Part 204, Administrative Matters AGENCY: Defense Acquisition Regulations...

32 CFR 319.5 - Procedures for requests pertaining to individual records in a record system.

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2012-07-01

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32 CFR 319.5 - Procedures for requests pertaining to individual records in a record system.

Code of Federal Regulations, 2010 CFR

2010-07-01

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32 CFR 319.5 - Procedures for requests pertaining to individual records in a record system.

Code of Federal Regulations, 2014 CFR

2014-07-01

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32 CFR 701.128 - Exemptions for specific Navy record systems.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 5 2014-07-01 2014-07-01 false Exemptions for specific Navy record systems. 701.128 Section 701.128 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED... purposes by the Department of the Navy and the Department of Defense. [71 FR 27536, May 11, 2006, as...

48 CFR 252.225-7040 - Contractor Personnel Supporting U.S. Armed Forces Deployed Outside the United States.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS... Directive 3002.01E, Personnel Recovery in the Department of Defense. (o) Mortuary affairs. Contractor... Commander or as directed by the Secretary of Defense. (2) Contract performance in support of U.S. Armed...

32 CFR 323.6 - Exemption rules.

Code of Federal Regulations, 2013 CFR

2013-07-01

... DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM § 323.6 Exemption rules. (a) The Director, DLA or designee may... proceedings. (c) Exempt Records Systems. All systems of records maintained by the Defense Logistics Agency... Identifier: S500.20 (Specific exemption). (1) System name: Defense Logistics Agency (DLA) Criminal Incident...

32 CFR 323.6 - Exemption rules.

Code of Federal Regulations, 2014 CFR

2014-07-01

... DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM § 323.6 Exemption rules. (a) The Director, DLA or designee may... proceedings. (c) Exempt Records Systems. All systems of records maintained by the Defense Logistics Agency... Identifier: S500.20 (Specific exemption). (1) System name: Defense Logistics Agency (DLA) Criminal Incident...

Defense Planning and Programming Categories: A Special Tool for Special Needs. Volume 3. Appendix E. Proposed Expanded DPPC Structure

DTIC Science & Technology

1990-04-01

SURVEILLANCE & WARNING SYTEMS A2C COMMAND & CONTROL ACTIVITIES A2D SPACE ACTIVITIES (STRATEGIC CONTROL & SURV) A2E STRAT CONTROL & SURV: COMMUNICATIONS A2F...STRATEGIC AIR DEFENSE 0501802A NIKE-AJAX (ARNS) (H) AID STRATEGIC AIR DEFENSE AIC SPACE DEFENSE OI02115N F-6 Squadrons (H) AIC SPACE DEFENSE 0102215N ABM ...WARNING SYTEMS 0102310F NCHC - TW/AA Systems A2B SURVEILLANCE & WARNIIIG SYTEMS 0102311F NCMC - Space Defense Systems A21 SURVEILLANCE & WARNING SYTEMS

Using a Red Team to devise countermeasures

NASA Astrophysics Data System (ADS)

Swedenburg, R. L.

1995-01-01

The ability of a defense system to operate effectively when deployed in battle is dependent on designs able to deal with countermeasures against the defense. The formation of a technical Red Team to stress the preliminary designs of the defensive system with technologically feasible and effective potential countermeasures provides a means to identify such potential countermeasures. This paper describes the experience of the U.S. Ballistic Missile Defense Organization's (BMDO) Theater Missile Defense Red Team since the Gulf War in 1991, the Red-Blue Exchange process, and the value it has provided to the designers of the U.S. Theater Missile Defense systems for developing robust systems. A wide-range of technologically feasible countermeasures has been devised, analyzed, tested for feasibility, and provided to the system developers for mitigation design. The process for independently analyzing possible susceptibilities of preliminary designs and exploiting the susceptibilities to identify possible countermeasures is explained. Designing and characterizing the Red Team's countermeasures, determining their feasibility, and analyzing their potential effectiveness against the defense are explained. A technique for the Blue Team's designers to deal with a wide range of potential countermeasures is explained.

Utilizing an Intelligent Tutoring System in Tactical Action Officer Sandbox

DTIC Science & Technology

2014-06-01

Office of Naval Research Future Naval Capabilities, the Defense Technology Area Plan from 2005 and the Department of Defense Science and Technology ...LEFT BLANK v ABSTRACT The Office of Naval Research Future Naval Capabilities, the Defense Technology Area Plan from 2005 and the Department...of Defense Science and Technology Priorities for FY13-17 all share a focus on systems to promote warfighter performance. The goal of these systems is

32 CFR 162.4 - Policy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Policy. 162.4 Section 162.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING PRODUCTIVITY ENHANCING CAPITAL...D Component investment planning and of the Defense Planning, Programming, and Budgeting System (PPBS...

32 CFR 162.4 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Policy. 162.4 Section 162.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING PRODUCTIVITY ENHANCING CAPITAL...D Component investment planning and of the Defense Planning, Programming, and Budgeting System (PPBS...

32 CFR 162.4 - Policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Policy. 162.4 Section 162.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING PRODUCTIVITY ENHANCING CAPITAL...D Component investment planning and of the Defense Planning, Programming, and Budgeting System (PPBS...

32 CFR 162.4 - Policy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Policy. 162.4 Section 162.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING PRODUCTIVITY ENHANCING CAPITAL...D Component investment planning and of the Defense Planning, Programming, and Budgeting System (PPBS...

Cost of space-based laser ballistic missile defense.

PubMed

Field, G; Spergel, D

1986-03-21

Orbiting platforms carrying infrared lasers have been proposed as weapons forming the first tier of a ballistic missile defense system under the President's Strategic Defense Initiative. As each laser platform can destroy a limited number of missiles, one of several methods of countering such a system is to increase the number of offensive missiles. Hence it is important to know whether the cost-exchange ratio, defined as the ratio of the cost to the defense of destroying a missile to the cost to the offense of deploying an additional missile, is greater or less than 1. Although the technology to be used in a ballistic missile defense system is still extremely uncertain, it is useful to examine methods for calculating the cost-exchange ratio. As an example, the cost of an orbiting infrared laser ballistic missile defense system employed against intercontinental ballistic missiles launched simultaneously from a small area is compared to the cost of additional offensive missiles. If one adopts lower limits to the costs for the defense and upper limits to the costs for the offense, the cost-exchange ratio comes out substantially greater than 1. If these estimates are confirmed, such a ballistic missile defense system would be unable to maintain its effectiveness at less cost than it would take to proliferate the ballistic missiles necessary to overcome it and would therefore not satisfy the President's requirements for an effective strategic defense. Although the method is illustrated by applying it to a space-based infrared laser system, it should be straightforward to apply it to other proposed systems.

Cost of space-based laser ballistic missile defense

DOE Office of Scientific and Technical Information (OSTI.GOV)

Field, G.; Spergel, D.

1986-03-21

Orbiting platforms carrying infrared lasers have been proposed as weapons forming the first tier of a ballistic missile defense system under the President's Strategic Defense Initiative. As each laser platform can destroy a limited number of missiles, one of several methods of countering such a system is to increase the number of offensive missiles. Hence it is important to know whether the cost-exchange ratio, defined as the ratio of the cost to the defense of destroying a missile to the cost to the offense of deploying an additional missile, is greater or less than 1. Although the technology to bemore » used in a ballistic missile defense system is still extremely uncertain, it is useful to examine methods for calculating the cost-exchange ration. As an example, the cost of an orbiting infrared laser ballistic missile defense system employed against intercontinental ballistic missiles launched simultaneously from a small area is compared to the cost of additional offensive missiles. If one adopts lower limits to the costs for the defense and upper limits to the costs for the offense, the cost-exchange ratio comes out substantially greater than 1. If these estimates are confirmed, such a ballistic missile defense system would be unable to maintain its effectiveness at less cost than it would take to proliferate the ballistic missiles necessary to overcome it and would therefore not satisfy the President's requirements for an effective strategic defense. Although the method is illustrated by applying it to a space-based infrared laser system, it should be straightforward to apply it to other proposed systems. 28 references, 2 tables.« less

75 FR 54526 - Defense Federal Acquisition Regulation Supplement; Additional Requirements Applicable to...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-08

... Procurement of Major Systems of the Department of Defense.'' DATES: Effective Date: September 8, 2010. FOR... 217 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System. 0... funding or reprogramming for procurement of a major system under a multiyear contract authorized under...

5 CFR 9901.221 - Classification requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Section 9901.221 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM (NSPS) Classification Classification Process § 9901.221 Classification...

48 CFR 242.7301 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 242.7301 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contractor Insurance/Pension Review.../Insurance Pension Review (CIPR). Defense Contract Management Agency (DCMA) insurance/pension specialists and...

48 CFR 242.7301 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 242.7301 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contractor Insurance/Pension Review.../Insurance Pension Review (CIPR). Defense Contract Management Agency (DCMA) insurance/pension specialists and...

75 FR 10471 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

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75 FR 3178 - Defense Federal Acquisition Regulation Supplement; Lead System Integrators

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

... Government procurement. Amy G. Williams, Editor, Defense Acquisition Regulations System. 0 Accordingly, the..., without change, an interim rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to... limitations on the award of new contracts for lead system integrator functions in the acquisition of major DoD...

32 CFR Appendix H to Part 323 - DLA Exemption Rules

Code of Federal Regulations, 2012 CFR

2012-07-01

... PROGRAM DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM Pt. 323, App. H Appendix H to Part 323—DLA Exemption Rules Exempted Records Systems. All systems of records maintained by the Defense Logistics Agency will.... b. ID: S500.20 (Specific exemption). 1. System name: Defense Logistics Agency Criminal Incident...

32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral System...

32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral System...

32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral System...

32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral System...

32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral System...

Detection technique of targets for missile defense system

NASA Astrophysics Data System (ADS)

Guo, Hua-ling; Deng, Jia-hao; Cai, Ke-rong

2009-11-01

Ballistic missile defense system (BMDS) is a weapon system for intercepting enemy ballistic missiles. It includes ballistic-missile warning system, target discrimination system, anti-ballistic-missile guidance systems, and command-control communication system. Infrared imaging detection and laser imaging detection are widely used in BMDS for surveillance, target detection, target tracking, and target discrimination. Based on a comprehensive review of the application of target-detection techniques in the missile defense system, including infrared focal plane arrays (IRFPA), ground-based radar detection technology, 3-dimensional imaging laser radar with a photon counting avalanche photodiode (APD) arrays and microchip laser, this paper focuses on the infrared and laser imaging detection techniques in missile defense system, as well as the trends for their future development.

75 FR 32639 - Defense Federal Acquisition Regulation Supplement; Limitations on Procurements With Non-Defense...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... elements of the Department of Homeland Security concerned with the analysis of intelligence information... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 217 RIN 0750-AG67 Defense Federal Acquisition Regulation Supplement; Limitations on Procurements With Non-Defense Agencies (DFARS...

The Transcription Factor ABI4 Is Required for the Ascorbic Acid–Dependent Regulation of Growth and Regulation of Jasmonate-Dependent Defense Signaling Pathways in Arabidopsis[C][W

PubMed Central

Kerchev, Pavel I.; Pellny, Till K.; Vivancos, Pedro Diaz; Kiddle, Guy; Hedden, Peter; Driscoll, Simon; Vanacker, Hélène; Verrier, Paul; Hancock, Robert D.; Foyer, Christine H.

2011-01-01

Cellular redox homeostasis is a hub for signal integration. Interactions between redox metabolism and the ABSCISIC ACID-INSENSITIVE-4 (ABI4) transcription factor were characterized in the Arabidopsis thaliana vitamin c defective1 (vtc1) and vtc2 mutants, which are defective in ascorbic acid synthesis and show a slow growth phenotype together with enhanced abscisic acid (ABA) levels relative to the wild type (Columbia-0). The 75% decrease in the leaf ascorbate pool in the vtc2 mutants was not sufficient to adversely affect GA metabolism. The transcriptome signatures of the abi4, vtc1, and vtc2 mutants showed significant overlap, with a large number of transcription factors or signaling components similarly repressed or induced. Moreover, lincomycin-dependent changes in LIGHT HARVESTING CHLOROPHYLL A/B BINDING PROTEIN 1.1 expression were comparable in these mutants, suggesting overlapping participation in chloroplast to nucleus signaling. The slow growth phenotype of vtc2 was absent in the abi4 vtc2 double mutant, as was the sugar-insensitive phenotype of the abi4 mutant. Octadecanoid derivative-responsive AP2/ERF-domain transcription factor 47 (ORA47) and AP3 (an ABI5 binding factor) transcripts were enhanced in vtc2 but repressed in abi4 vtc2, suggesting that ABI4 and ascorbate modulate growth and defense gene expression through jasmonate signaling. We conclude that low ascorbate triggers ABA- and jasmonate-dependent signaling pathways that together regulate growth through ABI4. Moreover, cellular redox homeostasis exerts a strong influence on sugar-dependent growth regulation. PMID:21926335

Overexpression of miR169o, an Overlapping microRNA in Response to Both Nitrogen Limitation and Bacterial Infection, Promotes Nitrogen Use Efficiency and Susceptibility to Bacterial Blight in Rice.

PubMed

Chao, Yu; Chen, Yutong; Cao, Yaqian; Chen, Huamin; Wang, Jichun; Bi, Yong-Mei; Tian, Fang; Yang, Fenghuan; Rothstein, Steven J; Zhou, Xueping; He, Chenyang

2018-03-15

Limiting nitrogen (N) supply contributes to improved resistance to bacterial blight (BB) caused by Xanthomonas oryzae pv. oryzae (Xoo) in susceptible rice (Oryza sativa). To understand the regulatory roles of microRNAs in this phenomenon, sixty-three differentially-expressed overlapping miRNAs in response to Xoo infection and N-limitation stress in rice were identified through deep RNA-sequence and stem loop qRT-PCR. Among these, miR169o was further assessed as a typical overlapping miRNA through the overexpression of the miR169o primary gene. Osa-miR169o-OX plants were taller, and had more biomass accumulation with significantly increased nitrate and total amino acid contents in roots than wild type (WT). Transcript level assays showed that under different N supply conditions miR169o opposite regulated NRT2 which is reduced under normal N supply condition but remarkably induced under N limiting stress. On the other hand, osa-miR169o-OX plants also displayed increased disease lesion lengths and reduced transcriptional levels of defense gene (PR1b, PR10a, PR10b and PAL) compared with WT after inoculation with Xoo. In addition, miR169o impeded Xoo-mediated NRT transcription. Therefore, the overlapping miR169o contributes to increase N use efficiency and negatively regulates the resistance to bacterial blight in rice. Consistently, transient expression of NF-YAs in rice protoplast promoted the transcripts of PR genes and NRT2 genes, while reduced the transcripts of NRT1 genes. Our results provide novel and additional insights into the coordinated regulatory mechanisms of crosstalk between Xoo infection and N-deficiency responses in rice.

48 CFR 225.7016-1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... with Foreign Entities for the Conduct of Ballistic Missile Defense Research, Development, Test, and... Section 225.7016-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Authorization Acts, Appropriations Acts, and...

48 CFR 216.504 - Indefinite-quantity contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Deputy Director, Defense Procurement and Acquisition Policy (Contract Policy and International... contracts. 216.504 Section 216.504 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Indefinite...

5 CFR 9901.104 - Scope of authority.

Code of Federal Regulations, 2010 CFR

2010-01-01

....104 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY... with performance appraisal systems; (b) Chapter 51, dealing with General Schedule job classification...

5 CFR 9901.504 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM (NSPS) Staffing and Employment General § 9901.504 Definitions. In this subpart— Career conditional...

Real-world injury patterns associated with Hybrid III sternal deflections in frontal crash tests.

PubMed

Brumbelow, Matthew L; Farmer, Charles M

2013-01-01

This study investigated the relationship between the peak sternal deflection measurements recorded by the Hybrid III 50th percentile male anthropometric test device (ATD) in frontal crash tests and injury and fatality outcomes for drivers in field crashes. ATD sternal deflection data were obtained from the Insurance Institute for Highway Safety's 64 km/h, 40 percent overlap crashworthiness evaluation tests for vehicles with seat belt crash tensioners, load limiters, and good-rated structure. The National Automotive Sampling System Crashworthiness Data System (NASS-CDS) was queried for frontal crashes of these vehicles in which the driver was restrained by a seat belt and air bag. Injury probability curves were calculated by frontal crash type using the injuries coded in NASS-CDS and peak ATD sternal deflection data. Fatality Analysis Reporting System (FARS) front-to-front crashes with exactly one driver death were also studied to determine whether the difference in measured sternal deflections for the 2 vehicles was related to the odds of fatality. For center impacts, moderate overlaps, and large overlaps in NASS-CDS, the probability of the driver sustaining an Abbreviated Injury Scale (AIS) score ≥ 3 thoracic injury, or any nonextremity AIS ≥ 3 injury, increased with increasing ATD sternal deflection measured in crash tests. For small overlaps, however, these probabilities decreased with increasing deflection. For FARS crashes, the fatally injured driver more often was in the vehicle with the lower measured deflection in crash tests (55 vs. 45%). After controlling for other factors, a 5-mm difference in measured sternal deflections between the 2 vehicles was associated with a fatality odds ratio of 0.762 for the driver in the vehicle with the greater deflection (95% confidence interval = 0.373, 1.449). Restraint systems that reduce peak Hybrid III sternal deflection in a moderate overlap crash test are beneficial in real-world crashes with similar or greater overlap but likely have a disbenefit in crashes with small overlap. This may occur because belt-force limiters employed to control deflections allow excursion that could produce contact with interior vehicle components in small overlaps, given the more oblique occupant motion and potential inboard movement of the air bag. Although based on a limited number of cases, this interpretation is supported by differences in skeletal fracture locations among drivers in crashes with different overlaps. Current restraint systems could be improved by designs that reduce sternal deflection in moderate and large overlap crashes without increasing occupant excursion in small overlap crashes.

Uncertainties in building a strategic defense.

PubMed

Zraket, C A

1987-03-27

Building a strategic defense against nuclear ballistic missiles involves complex and uncertain functional, spatial, and temporal relations. Such a defensive system would evolve and grow over decades. It is too complex, dynamic, and interactive to be fully understood initially by design, analysis, and experiments. Uncertainties exist in the formulation of requirements and in the research and design of a defense architecture that can be implemented incrementally and be fully tested to operate reliably. The analysis and measurement of system survivability, performance, and cost-effectiveness are critical to this process. Similar complexities exist for an adversary's system that would suppress or use countermeasures against a missile defense. Problems and opportunities posed by these relations are described, with emphasis on the unique characteristics and vulnerabilities of space-based systems.

Joint Operational Medicine Information Systems (JOMIS)

DTIC Science & Technology

2016-03-01

Component is Program Executive Office (PEO) Department of Defense (DoD) Healthcare Management Systems (DHMS) for Defense Health Agency (DHA). Responsible...AT&L)) and the Program Executive Office (PEO) Defense Healthcare Management Systems (DHMS). ​Operational medicine is the application of routine and...acquired by the DoD Healthcare Management System Modernization (DHMSM) program for Health Care Delivery (HCD) capabilities. JOMIS future release(s

Codifying Information Assurance Controls for Department of Defense (DoD) Supervisory Control and Data Acquisition (SCADA) Systems

DTIC Science & Technology

2010-03-01

CODIFYING INFORMATION ASSURANCE CONTROLS FOR DEPARTMENT OF DEFENSE (DOD) SUPERVISORY CONTROL AND DATA...Force, Department of Defense, or the U.S. Government. AFIT/GCO/ENG/10-13 CODIFYING INFORMATION ASSURANCE CONTROLS FOR DEPARTMENT OF...DEFENSE (DOD) SUPERVISORY CONTROL AND DATA ACQUISITION (SCADA) SYSTEMS THESIS Presented to the Faculty Department of Electrical and Computer

1990 Annual Tropical Cyclone Report

DTIC Science & Technology

1995-01-01

land) - followed further loss of convective organization as system underwent increased vertical wind shear and loss of latent and sensible heat. III...FOLXTECHNICOF HONG KONG CIUDAD UNIVERSITARLA,M)XICO CML DEFENSE, BELAU CML DEFENSE, MAJURO CML DEFENSE, POHNPEI CML DEFENSE, SAIPAN CML DEFENSE, TRUK

Hitting the sweet spot-glycans as targets of fungal defense effector proteins.

PubMed

Künzler, Markus

2015-05-06

Organisms which rely solely on innate defense systems must combat a large number of antagonists with a comparably low number of defense effector molecules. As one solution of this problem, these organisms have evolved effector molecules targeting epitopes that are conserved between different antagonists of a specific taxon or, if possible, even of different taxa. In order to restrict the activity of the defense effector molecules to physiologically relevant taxa, these target epitopes should, on the other hand, be taxon-specific and easily accessible. Glycans fulfill all these requirements and are therefore a preferred target of defense effector molecules, in particular defense proteins. Here, we review this defense strategy using the example of the defense system of multicellular (filamentous) fungi against microbial competitors and animal predators.

5 CFR 9901.222 - Review of classification decisions.

Code of Federal Regulations, 2011 CFR

2011-01-01

....222 Section 9901.222 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM (NSPS) Classification Classification Process § 9901.222 Review of...

48 CFR 225.7016-2 - Restriction.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the Ballistic Missile Defense Program. [68 FR 15627, Mar. 31, 2003. Redesignated at 74 FR 53413, Oct... Section 225.7016-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Authorization Acts, Appropriations Acts, and...

5 CFR 9901.304 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... accomplishment of the organization's mission and goals. CONUS or Continental United States means the States of...

5 CFR 9901.304 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... accomplishment of the organization's mission and goals. CONUS or Continental United States means the States of...

5 CFR 9901.404 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM (NSPS) Performance Management § 9901.404 Definitions. In this subpart— Appraisal means the review and...

5 CFR 9901.413 - Reconsideration of ratings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Section 9901.413 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM (NSPS) Performance Management § 9901.413 Reconsideration of ratings. (a...

32 CFR 37.605 - What is the general policy on participants' financial, property, and purchasing systems?

Code of Federal Regulations, 2010 CFR

2010-07-01

...' financial, property, and purchasing systems? 37.605 Section 37.605 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Award Terms Affecting Participants' Financial, Property, and Purchasing Systems § 37.605 What is the...

77 FR 19266 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-30

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2012-OS-0040] Privacy Act of 1974; System of Records AGENCY: Office of the Secretary of Defense, DoD. ACTION: Notice to alter a system of... Department of Defense (DoD) civilian employees including Foreign Nationals, retired personnel, former DoD...

76 FR 66916 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DOD-2011-OS-0118] Privacy Act of 1974; System of Records AGENCY: Office of the Secretary, Department of Defense (DoD). ACTION: Notice to Amend a.... Aaron Siegel, Alternate OSD Federal Register Liaison Officer, Department of Defense. DWHS E05 System...

76 FR 76959 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-09

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2011-OS-0143] Privacy Act of 1974; System of Records AGENCY: Office of the Secretary, Department of Defense (DoD). ACTION: Notice to Alter a... OSD Federal Register Liaison Officer, Department of Defense. DWHS D01 System name: DoD National...

76 FR 3099 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-19

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2011-OS-0006] Privacy Act of 1974; System of Records AGENCY: Office of the Secretary of Defense, DoD. ACTION: Notice to Add a System of...: January 11, 2011. Morgan F. Park, Alternate OSD Federal Register Liaison Officer, Department of Defense...

76 FR 76958 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-09

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2011-OS-0141] Privacy Act of 1974; System of Records AGENCY: Office of the Secretary, Department of Defense (DoD). ACTION: Notice to Amend a... Siegel, Alternate OSD Federal Register Liaison Officer, Department of Defense. DWHS P18 System name...

78 FR 63462 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-24

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [Docket Number DARS-2013-0035] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Organizational Conflict..., Department of Defense (DoD). ACTION: Notice and request for comments regarding a proposed extension of an...

5 CFR 3601.102 - Designation of separate agency components.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Service; (8) Defense Information Systems Agency; (9) Defense Intelligence Agency; (10) Defense Logistics... ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF DEFENSE § 3601.102 Designation of separate agency...

48 CFR 201.170 - Peer Reviews.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 201.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... Peer Reviews, the military departments, defense agencies, and DoD field activities shall provide a... departments, defense agencies, and DoD field activities shall establish procedures for— (1) Pre-award Peer...

48 CFR 201.170 - Peer Reviews.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 201.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... Peer Reviews, the military departments, defense agencies, and DoD field activities shall provide a... departments, defense agencies, and DoD field activities shall establish procedures for— (1) Pre-award Peer...

Evolution of System Safety at NASA as Related to Defense-in-Depth

NASA Technical Reports Server (NTRS)

Dezfuli, Homayoon

2015-01-01

Presentation given at the Defense-in-Depth Inter-Agency Workshop on August 26, 2015 in Rockville, MD by Homayoon Dezfuli. The presentation addresses the evolution of system safety at NASA as related to Defense-in-Depth.

5 CFR 9901.356 - Pay retention.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... employee who would not be affected personally requests a reduction in band; (ii) Management determines the...

48 CFR 235.010 - Scientific and technical reports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... reports. 235.010 Section 235.010 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.010 Scientific and technical reports. (b) For DoD, the Defense Technical Information Center is...

48 CFR 235.010 - Scientific and technical reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... reports. 235.010 Section 235.010 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.010 Scientific and technical reports. (b) For DoD, the Defense Technical Information Center is...

48 CFR 235.010 - Scientific and technical reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... reports. 235.010 Section 235.010 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.010 Scientific and technical reports. (b) For DoD, the Defense Technical Information Center is...

48 CFR 230.201-5 - Waiver.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 230.201-5 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF... 230.201-5 Waiver. (a)(1)(A) The military departments and the Director, Defense Procurement and... waiver requests to the Director, Defense Procurement and Acquisition Policy. (2) The military departments...

48 CFR 235.010 - Scientific and technical reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... reports. 235.010 Section 235.010 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.010 Scientific and technical reports. (b) For DoD, the Defense Technical Information Center is...

48 CFR 235.010 - Scientific and technical reports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... reports. 235.010 Section 235.010 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.010 Scientific and technical reports. (b) For DoD, the Defense Technical Information Center is...

5 CFR 9901.407 - Minimum period of performance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Section 9901.407 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM (NSPS) Performance Management § 9901.407 Minimum period of performance. (a) Only...

5 CFR 9901.406 - Setting and communicating performance expectations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... expectations. 9901.406 Section 9901.406 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM (NSPS) Performance Management § 9901.406 Setting and...

5 CFR 9901.204 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... meaning given that term in § 9901.103. Classification, also referred to as job evaluation, means the...

5 CFR 9901.321 - Structure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... career group, the Secretary will establish a common rate range that applies in all locations. (c) The...

5 CFR 9901.311 - Major features.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... structure of rate ranges linked to various pay bands for each career group, in alignment with the...

NEXT GENERATION AERIAL REFUELING: CRITICAL CAPABILITY FOR PENETRATING CHINESE DENIED ENVIRONMENTS

DTIC Science & Technology

2015-10-26

defensive systems capability reduces aircraft damage, saves aircrew lives and keeps the tanker engaged in supplying a critical resource to the...legacy KC- 135. Additionally, there are requirement for a defensive system , which enhances the pilots situational awareness. The defensive system ...1 The ALR-69(V) is the world’s first all-digital radar warning receiver (RWR). The RWR system detects, identifies

Defense Intelligence: Additional Steps Could Better Integrate Intelligence Input into DODs Acquisition of Major Weapon Systems

DTIC Science & Technology

2016-11-01

DEFENSE INTELLIGENCE Additional Steps Could Better Integrate Intelligence Input into DOD’s Acquisition of Major Weapon...States Government Accountability Office Highlights of GAO-17-10, a report to congressional committees November 2016 DEFENSE INTELLIGENCE ...Additional Steps Could Better Integrate Intelligence Input into DOD’s Acquisition of Major Weapon Systems What GAO Found The Department of Defense (DOD

32 CFR 64.5 - Responsibilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Defense Agencies, the Secretary of Homeland Security, the Director of the Selective Service System, and... 32 National Defense 1 2012-07-01 2012-07-01 false Responsibilities. 64.5 Section 64.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN...

75 FR 32416 - Defense Science Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... DEPARTMENT OF DEFENSE Office of the Secretary Defense Science Board AGENCY: Department of Defense (DoD). ACTION: Notice of advisory committee meeting. SUMMARY: The Defense Science Board Task Force on the Survivability of DoD Systems and Assets to Electromagnetic Pulse (EMP) and other Nuclear Weapons...

Defense Primer: The National Defense Budget Function (050)

DTIC Science & Technology

2017-03-17

in parenthesis). This defense primer addresses the National Defense Budget (050), which is frequently used to explain trends in military spending...but which also includes some activities not conducted by the Department of Defense. What Is the Purpose of the Budget Function System? The budget

32 CFR 316.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Purpose. 316.1 Section 316.1 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY PRIVACY PROGRAM § 316.1 Purpose. This part delineates responsibility and provides...

Plastic Transcriptomes Stabilize Immunity to Pathogen Diversity: The Jasmonic Acid and Salicylic Acid Networks within the Arabidopsis/Botrytis Pathosystem[OPEN

PubMed Central

Eshbaugh, Robert; Chen, Fang; Atwell, Susana

2017-01-01

To respond to pathogen attack, selection and associated evolution has led to the creation of plant immune system that are a highly effective and inducible defense system. Central to this system are the plant defense hormones jasmonic acid (JA) and salicylic acid (SA) and crosstalk between the two, which may play an important role in defense responses to specific pathogens or even genotypes. Here, we used the Arabidopsis thaliana-Botrytis cinerea pathosystem to test how the host’s defense system functions against genetic variation in a pathogen. We measured defense-related phenotypes and transcriptomic responses in Arabidopsis wild-type Col-0 and JA- and SA-signaling mutants, coi1-1 and npr1-1, individually challenged with 96 diverse B. cinerea isolates. Those data showed genetic variation in the pathogen influences on all components within the plant defense system at the transcriptional level. We identified four gene coexpression networks and two vectors of defense variation triggered by genetic variation in B. cinerea. This showed that the JA and SA signaling pathways functioned to constrain/canalize the range of virulence in the pathogen population, but the underlying transcriptomic response was highly plastic. These data showed that plants utilize major defense hormone pathways to buffer disease resistance, but not the metabolic or transcriptional responses to genetic variation within a pathogen. PMID:29042403

Plastic Transcriptomes Stabilize Immunity to Pathogen Diversity: The Jasmonic Acid and Salicylic Acid Networks within the Arabidopsis/Botrytis Pathosystem.

PubMed

Zhang, Wei; Corwin, Jason A; Copeland, Daniel; Feusier, Julie; Eshbaugh, Robert; Chen, Fang; Atwell, Susana; Kliebenstein, Daniel J

2017-11-01

To respond to pathogen attack, selection and associated evolution has led to the creation of plant immune system that are a highly effective and inducible defense system. Central to this system are the plant defense hormones jasmonic acid (JA) and salicylic acid (SA) and crosstalk between the two, which may play an important role in defense responses to specific pathogens or even genotypes. Here, we used the Arabidopsis thaliana - Botrytis cinerea pathosystem to test how the host's defense system functions against genetic variation in a pathogen. We measured defense-related phenotypes and transcriptomic responses in Arabidopsis wild-type Col-0 and JA- and SA-signaling mutants, coi1-1 and npr1-1 , individually challenged with 96 diverse B. cinerea isolates. Those data showed genetic variation in the pathogen influences on all components within the plant defense system at the transcriptional level. We identified four gene coexpression networks and two vectors of defense variation triggered by genetic variation in B. cinerea This showed that the JA and SA signaling pathways functioned to constrain/canalize the range of virulence in the pathogen population, but the underlying transcriptomic response was highly plastic. These data showed that plants utilize major defense hormone pathways to buffer disease resistance, but not the metabolic or transcriptional responses to genetic variation within a pathogen. © 2017 American Society of Plant Biologists. All rights reserved.

A Resonance Overlap Criterion for the Onset of Chaos in Systems of Two Eccentric Planets

NASA Astrophysics Data System (ADS)

Hadden, Sam; Lithwick, Yoram

2018-04-01

I will desrcribe a new analytic criterion to predict the onset of chaos in systems consisting of two massive, eccentric planets. Given a planet pair's spacing and masses, the criterion predicts the eccentricities at which the onset of large-scale chaos occurs. The onset of chaos is predicted based on overlap of mean motion resonances as in Wisdom (1980)'s pioneering work. Whereas Wisdom's work was limited to the overlap of first-order resonance and therefore to nearly circular planets, we account for resonances of all orders. This allows us to consider resonance overlap for planets with arbitrary eccentricities (up to orbit-crossing). Our results show excellent agreement with numerical simulations.

Defense Agencies Initiative Increment 2 (DAI Inc 2)

DTIC Science & Technology

2016-03-01

2016 Major Automated Information System Annual Report Defense Agencies Initiative Increment 2 (DAI Inc 2) Defense Acquisition Management...Automated Information System MAIS OE - MAIS Original Estimate MAR – MAIS Annual Report MDA - Milestone Decision Authority MDD - Materiel Development...management systems supporting diverse operational functions and the warfighter in decision making and financial reporting . These disparate, non

75 FR 51327 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-19

..., and defense services for the Hughes Air Defense Radar and Air Defense System (HADAR) in Taiwan for the... technical data, and defense services, for the GD-53 Multimode Radar on Taiwan's Indigenous Defensive Fighter... agreement associated with this notification consists of components of the GD-53 Multimode Radar. The end...

48 CFR 201.402 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Policy. 201.402 Section... DEFENSE GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 201.402 Policy. (1) The Director of Defense Procurement and Acquisition Policy, Office of the Under Secretary of Defense...

48 CFR 252.245-7004 - Reporting, Reutilization, and Disposal.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., and Disposal. 252.245-7004 Section 252.245-7004 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT.... Government under surplus sales contracts; (iii) Designated by the Department of Defense as ineligible...

48 CFR 252.245-7004 - Reporting, Reutilization, and Disposal.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., and Disposal. 252.245-7004 Section 252.245-7004 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... surplus sales contracts; (iii) Designated by the Department of Defense as ineligible, debarred, or...

48 CFR 252.245-7004 - Reporting, Reutilization, and Disposal.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., and Disposal. 252.245-7004 Section 252.245-7004 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT.... Government under surplus sales contracts; (iii) Designated by the Department of Defense as ineligible...

48 CFR 252.245-7004 - Reporting, Reutilization, and Disposal.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., and Disposal. 252.245-7004 Section 252.245-7004 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... surplus sales contracts; (iii) Designated by the Department of Defense as ineligible, debarred, or...

5 CFR 9901.222 - Review of classification decisions.

Code of Federal Regulations, 2010 CFR

2010-01-01

....222 Section 9901.222 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE...., pay system, career group, occupational series, official title, pay schedule, or pay band) of his or...

5 CFR 9901.371 - Conversion into NSPS pay system.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Section 9901.371 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL....231 for conversion rules related to determining an employee's career group, pay schedule, and band...

5 CFR 9901.351 - General.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM... § 9901.354) in an NSPS position from a GS or FWS position through a management-directed action (except...

5 CFR 9901.211 - Career groups.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Career groups. 9901.211 Section 9901.211 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL SYSTEM...

32 CFR 636.20 - Point system procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Point system procedures. 636.20 Section 636.20 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION (SPECIFIC INSTALLATIONS) Fort Stewart, Georgia...

Müllerian mimicry in aposematic spiny plants.

PubMed

Lev-Yadun, Simcha

2009-06-01

Müllerian mimicry is common in aposematic animals but till recently, like other aspects of plant aposematism was almost unknown. Many thorny, spiny and prickly plants are considered aposematic because their sharp defensive structures are colorful and conspicuous. Many of these spiny plant species (e.g., cacti and Agave in North American deserts; Aloe, Euphorbia and acacias with white thorns in Africa; spiny plants in Ohio; and spiny members of the Asteraceae in the Mediterranean basin) have overlapping territories, and also similar patterns of conspicuous coloration, and suffer from the evolutionary pressure of grazing by the same large herbivores. I propose that many of these species form Müllerian mimicry rings.

32 CFR 287.3 - Authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Authority. 287.3 Section 287.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 287.3 Authority. This part...

32 CFR 287.9 - Reports.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Reports. 287.9 Section 287.9 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 287.9 Reports. An annual...

32 CFR 316.3 - Authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Authority. 316.3 Section 316.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY PRIVACY PROGRAM § 316.3 Authority. This part is published in accordance with the...

32 CFR 287.7 - Fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Fees. 287.7 Section 287.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 287.7 Fees. Fees charged...

32 CFR 316.7 - Questions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Questions. 316.7 Section 316.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY PRIVACY PROGRAM § 316.7 Questions. Questions on both the substance and procedure of...

Plant defense compounds: systems approaches to metabolic analysis.

PubMed

Kliebenstein, Daniel J

2012-01-01

Systems biology attempts to answer biological questions by integrating across diverse genomic data sets. With the increasing ability to conduct genomics experiments, this integrative approach is being rapidly applied across numerous biological research communities. One of these research communities investigates how plants utilize secondary metabolites or defense metabolites to defend against attack by pathogens and other biotic organisms. This use of systems biology to integrate across transcriptomics, metabolomics, and genomics is significantly enhancing the rate of discovery of genes, metabolites, and bioactivities for plant defense compounds as well as extending our knowledge of how these compounds are regulated. Plant defense compounds are also providing a unique proving platform to develop new approaches that enhance the ability to conduct systems biology with existing and previously unforseen genomics data sets. This review attempts to illustrate both how systems biology is helping the study of plant defense compounds and vice versa.

Information Resource Management Planning in the Office of the Under Secretary of Defense (Acquisition)

DTIC Science & Technology

1989-08-01

Include in this plan the role of the Defense Technical Information Center (DTIC), the Defense Technology Security Administration ( DTSA ), and ODDR&E’s...DTIC = Defense Technical Information Center DTSA = Defense Technology Security Administration DUSD = Deputy Under Secretary of Defense Gloss. 2 DUSD...technologically sensitive requests. The Defense Technology Security Administi ation ( DTSA ) is developing a large system to track foreign military sales

48 CFR 252.246-7000 - Material inspection and receiving report.

Code of Federal Regulations, 2011 CFR

2011-10-01

... receiving report. 252.246-7000 Section 252.246-7000 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... extent required by Appendix F, Material Inspection and Receiving Report, of the Defense FAR Supplement...

48 CFR 252.246-7000 - Material inspection and receiving report.

Code of Federal Regulations, 2013 CFR

2013-10-01

... receiving report. 252.246-7000 Section 252.246-7000 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... extent required by Appendix F, Material Inspection and Receiving Report, of the Defense FAR Supplement...

48 CFR 252.246-7000 - Material inspection and receiving report.

Code of Federal Regulations, 2014 CFR

2014-10-01

... receiving report. 252.246-7000 Section 252.246-7000 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... extent required by Appendix F, Material Inspection and Receiving Report, of the Defense FAR Supplement...

48 CFR 252.246-7000 - Material inspection and receiving report.

Code of Federal Regulations, 2010 CFR

2010-10-01

... receiving report. 252.246-7000 Section 252.246-7000 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... extent required by Appendix F, Material Inspection and Receiving Report, of the Defense FAR Supplement...

48 CFR 252.246-7000 - Material inspection and receiving report.

Code of Federal Regulations, 2012 CFR

2012-10-01

... receiving report. 252.246-7000 Section 252.246-7000 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... extent required by Appendix F, Material Inspection and Receiving Report, of the Defense FAR Supplement...

32 CFR 1605.28 - Signing official papers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Signing official papers. 1605.28 Section 1605.28 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM SELECTIVE SERVICE SYSTEM ORGANIZATION District Appeal Boards § 1605.28 Signing official papers. Official documents issued...

32 CFR 1605.28 - Signing official papers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Signing official papers. 1605.28 Section 1605.28 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM SELECTIVE SERVICE SYSTEM ORGANIZATION District Appeal Boards § 1605.28 Signing official papers. Official documents issued...

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.

PubMed

Rosowski, Emily E; Deng, Qing; Keller, Nancy P; Huttenlocher, Anna

2016-12-15

Leukocyte motility is required for host defense responses. Rac-family Rho GTPases are implicated in leukocyte function; however, the distinct roles of different Rac isoforms in host defense in vivo have remained unclear. In this study, we generated Rac2-deficient zebrafish using transcription activator-like effector nucleases to directly compare the role of Rac2 in vivo in neutrophils and macrophages in motility and the response to infection. This zebrafish larval model is highly amenable to live imaging of leukocyte behavior, and we report that in rac2 -/- larvae both neutrophils and macrophages are defective in basic motility, leading to impaired responses to localized wounds or infections. rac2 -/- larvae are highly susceptible to infection with Pseudomonas aeruginosa, which can be almost fully rescued by ectopic expression of either Rac2 or Rac1 specifically in neutrophils, indicating that these isoforms have partially overlapping functions in vivo. Rescue of Rac2 expression specifically in macrophages also confers resistance to Pseudomonas infection, highlighting an important role for Rac2 in this leukocyte population as well. Surprisingly, in contrast to neutrophils expressing a Rac2 dominant inhibitory human disease mutation, rac2 -/- neutrophils do not have altered polarity or mobilization from hematopoietic tissue, suggesting that a different Rac isoform, such as Rac1, also contributes to these phenotypes in vivo. Copyright © 2016 by The American Association of Immunologists, Inc.

32 CFR 316.5 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 316.5 Section 316.5 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY PRIVACY PROGRAM § 316.5 Policy. It is the policy of DISA: (a) To preserve the...

The glabra1 Mutation Affects Cuticle Formation and Plant Responses to Microbes1[C][W][OA

PubMed Central

Xia, Ye; Yu, Keshun; Navarre, Duroy; Seebold, Kenneth; Kachroo, Aardra; Kachroo, Pradeep

2010-01-01

Systemic acquired resistance (SAR) is a form of defense that provides resistance against a broad spectrum of pathogens in plants. Previous work indicates a role for plastidial glycerolipid biosynthesis in SAR. Specifically, mutations in FATTY ACID DESATURASE7 (FAD7), which lead to reduced trienoic fatty acid levels and compromised plastidial lipid biosynthesis, have been associated with defective SAR. We show that the defective SAR in Arabidopsis (Arabidopsis thaliana) fad7-1 plants is not associated with a mutation in FAD7 but rather with a second-site mutation in GLABRA1 (GL1), a gene well known for its role in trichome formation. The compromised SAR in gl1 plants is associated with impairment in their cuticles. Furthermore, mutations in two other components of trichome development, GL3 and TRANSPARENT TESTA GLABRA1, also impaired cuticle development and SAR. This suggests an overlap in the biochemical pathways leading to cuticle and trichome development. Interestingly, exogenous application of gibberellic acid (GA) not only enhanced SAR in wild-type plants but also restored SAR in gl1 plants. In contrast to GA, the defense phytohoromes salicylic acid and jasmonic acid were unable to restore SAR in gl1 plants. GA application increased levels of cuticular components but not trichome formation on gl1 plants, thus implicating cuticle, but not trichomes, as an important component of SAR. Our findings question the prudence of using mutant backgrounds for genetic screens and underscore a need to reevaluate phenotypes previously studied in the gl1 background. PMID:20699396

48 CFR 245.105 - Contractors' property management system compliance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... management system compliance. 245.105 Section 245.105 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.105 Contractors' property management system compliance. (a) Definitions— (1) Acceptable property management system...

48 CFR 252.235-7011 - Final scientific or technical report.

Code of Federal Regulations, 2014 CFR

2014-10-01

... technical report. 252.235-7011 Section 252.235-7011 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... of the report; and (c) For submission of reports in other than paper copy, contact the Defense...

75 FR 58368 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-24

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DOD-2010-OS-0125] Privacy Act of 1974... Register Liaison Officer, Department of Defense. ZDO-001 System name: Accountability Records/Recall Rosters... commissaries, including Department of Defense (DoD) Federal employees, military service personnel not assigned...

48 CFR 252.235-7011 - Final scientific or technical report.

Code of Federal Regulations, 2012 CFR

2012-10-01

... technical report. 252.235-7011 Section 252.235-7011 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... of the report; and (c) For submission of reports in other than paper copy, contact the Defense...

48 CFR 252.235-7011 - Final scientific or technical report.

Code of Federal Regulations, 2010 CFR

2010-10-01

... technical report. 252.235-7011 Section 252.235-7011 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... of the report; and (c) For submission of reports in other than paper copy, contact the Defense...

48 CFR 252.235-7011 - Final scientific or technical report.

Code of Federal Regulations, 2011 CFR

2011-10-01

... technical report. 252.235-7011 Section 252.235-7011 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... of the report; and (c) For submission of reports in other than paper copy, contact the Defense...

48 CFR 252.235-7011 - Final scientific or technical report.

Code of Federal Regulations, 2013 CFR

2013-10-01

... technical report. 252.235-7011 Section 252.235-7011 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... of the report; and (c) For submission of reports in other than paper copy, contact the Defense...

48 CFR 247.573-3 - Annual reporting requirement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... requirement. 247.573-3 Section 247.573-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag... report to the congressional defense committees, by June 1st of each year, in accordance with Section 1017...

48 CFR 247.573-3 - Annual reporting requirement.

Code of Federal Regulations, 2013 CFR

2013-10-01

... requirement. 247.573-3 Section 247.573-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag... report to the congressional defense committees, by June 1st of each year, in accordance with Section 1017...

32 CFR 1605.59 - Signing official papers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Signing official papers. 1605.59 Section 1605.59 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM SELECTIVE SERVICE SYSTEM ORGANIZATION Local Boards § 1605.59 Signing official papers. Official papers issued by a local...

32 CFR 1605.59 - Signing official papers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Signing official papers. 1605.59 Section 1605.59 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM SELECTIVE SERVICE SYSTEM ORGANIZATION Local Boards § 1605.59 Signing official papers. Official papers issued by a local...

Effects of Gain/Loss Framing in Cyber Defense Decision-Making

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bos, Nathan; Paul, Celeste; Gersh, John

Cyber defense requires decision making under uncertainty. Yet this critical area has not been a strong focus of research in judgment and decision-making. Future defense systems, which will rely on software-defined networks and may employ ‘moving target’ defenses, will increasingly automate lower level detection and analysis, but will still require humans in the loop for higher level judgment. We studied the decision making process and outcomes of 17 experienced network defense professionals who worked through a set of realistic network defense scenarios. We manipulated gain versus loss framing in a cyber defense scenario, and found significant effects in one ofmore » two focal problems. Defenders that began with a network already in quarantine (gain framing) used a quarantine system more than those that did not (loss framing). We also found some difference in perceived workload and efficacy. Alternate explanations of these findings and implications for network defense are discussed.« less

Identification of putative TAL effector targets of the citrus canker pathogens shows functional convergence underlying disease development and defense response

PubMed Central

2014-01-01

Background Transcriptional activator-like (TAL) effectors, formerly known as the AvrBs3/PthA protein family, are DNA-binding effectors broadly found in Xanthomonas spp. that transactivate host genes upon injection via the bacterial type three-secretion system. Biologically relevant targets of TAL effectors, i.e. host genes whose induction is vital to establish a compatible interaction, have been reported for xanthomonads that colonize rice and pepper; however, citrus genes modulated by the TAL effectors PthA“s” and PthC“s” of the citrus canker bacteria Xanthomonas citri (Xc) and Xanthomonas aurantifolii pathotype C (XaC), respectively, are poorly characterized. Of particular interest, XaC causes canker disease in its host lemon (Citrus aurantifolia), but triggers a defense response in sweet orange. Results Based on, 1) the TAL effector-DNA binding code, 2) gene expression data of Xc and XaC-infiltrated sweet orange leaves, and 3) citrus hypocotyls transformed with PthA2, PthA4 or PthC1, we have identified a collection of Citrus sinensis genes potentially targeted by Xc and XaC TAL effectors. Our results suggest that similar with other strains of Xanthomonas TAL effectors, PthA2 and PthA4, and PthC1 to some extent, functionally converge. In particular, towards induction of genes involved in the auxin and gibberellin synthesis and response, cell division, and defense response. We also present evidence indicating that the TAL effectors act as transcriptional repressors and that the best scoring predicted DNA targets of PthA“s” and PthC“s” in citrus promoters predominantly overlap with or localize near to TATA boxes of core promoters, supporting the idea that TAL effectors interact with the host basal transcriptional machinery to recruit the RNA pol II and start transcription. Conclusions The identification of PthA“s” and PthC“s” targets, such as the LOB (LATERAL ORGAN BOUNDARY) and CCNBS genes that we report here, is key for the understanding of the canker symptoms development during host susceptibility, or the defenses of sweet orange against the canker bacteria. We have narrowed down candidate targets to a few, which pointed out the host metabolic pathways explored by the pathogens. PMID:24564253

Identification of putative TAL effector targets of the citrus canker pathogens shows functional convergence underlying disease development and defense response.

PubMed

Pereira, Andre L A; Carazzolle, Marcelo F; Abe, Valeria Y; de Oliveira, Maria L P; Domingues, Mariane N; Silva, Jaqueline C; Cernadas, Raul A; Benedetti, Celso E

2014-02-25

Transcriptional activator-like (TAL) effectors, formerly known as the AvrBs3/PthA protein family, are DNA-binding effectors broadly found in Xanthomonas spp. that transactivate host genes upon injection via the bacterial type three-secretion system. Biologically relevant targets of TAL effectors, i.e. host genes whose induction is vital to establish a compatible interaction, have been reported for xanthomonads that colonize rice and pepper; however, citrus genes modulated by the TAL effectors PthA"s" and PthC"s" of the citrus canker bacteria Xanthomonas citri (Xc) and Xanthomonas aurantifolii pathotype C (XaC), respectively, are poorly characterized. Of particular interest, XaC causes canker disease in its host lemon (Citrus aurantifolia), but triggers a defense response in sweet orange. Based on, 1) the TAL effector-DNA binding code, 2) gene expression data of Xc and XaC-infiltrated sweet orange leaves, and 3) citrus hypocotyls transformed with PthA2, PthA4 or PthC1, we have identified a collection of Citrus sinensis genes potentially targeted by Xc and XaC TAL effectors. Our results suggest that similar with other strains of Xanthomonas TAL effectors, PthA2 and PthA4, and PthC1 to some extent, functionally converge. In particular, towards induction of genes involved in the auxin and gibberellin synthesis and response, cell division, and defense response. We also present evidence indicating that the TAL effectors act as transcriptional repressors and that the best scoring predicted DNA targets of PthA"s" and PthC"s" in citrus promoters predominantly overlap with or localize near to TATA boxes of core promoters, supporting the idea that TAL effectors interact with the host basal transcriptional machinery to recruit the RNA pol II and start transcription. The identification of PthA"s" and PthC"s" targets, such as the LOB (lateral organ boundary) and CCNBS genes that we report here, is key for the understanding of the canker symptoms development during host susceptibility, or the defenses of sweet orange against the canker bacteria. We have narrowed down candidate targets to a few, which pointed out the host metabolic pathways explored by the pathogens.

UV Habitable Zones Further Constrain Possible Life

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-02-01

Where should we search for life in the universe? Habitable zones are traditionallydetermined based on the possibility of liquid water existing on a planet but ultraviolet (UV) radiation also plays a key role.The UV Habitable ZoneSchematic showing how the traditional habitable zones location and width changes around different types of stars. The UV habitable zone also hasdifferent locations and widths depending on the mass and metallicity of the star. [NASA/Kepler Mission/Dana Berry]Besides the presence of liquid water, there are other things life may need to persist. For life as we know it, one important elementis moderate UV radiation: if a planet receives too little UV flux, many biological compounds cant be synthesized. If it receives too much, however, then terrestrial biological systems (e.g. DNA) can be damaged.To determinethe most likely place to findpersistent life, we should therefore look for the region where a stars traditional habitable zone, within which liquid water is possible, overlaps with its UV habitable zone, within which the UV flux is at the right level to support life.Relationship between the stellar mass and location of the boundaries of the traditional and UV habitable zones for a solar-metallicity star. din and dout denote inner and outer boundaries, respectively. ZAMS and TMS denote when the star joins and leaves the main sequence, respectively. The traditional and UV habitable zones overlap only for stars of 11.5 solar masses. [Adapted from Oishi and Kamaya 2016]Looking for OverlapIn a recent study, two scientists from the National Defense Academy of Japan, Midori Oishi and Hideyuki Kamaya, explored howthe location of this UV habitable zone and that of its overlap with the traditional habitable zone might be affected by a stars mass and metallicity.Oishi and Kamaya developed a simple evolutional model of the UV habitable zone in stars in the mass range of 0.084 solar masses with metallicities of roughly solar metallicity (Z=0.02), a tenth of solar metallicity, and a hundredth of solar metallicity.They calculate the location of the inner and outer UV habitable zone boundaries for each star at the beginning and end of its main-sequence life. They then determine the region for which the UV habitable zone and the traditional habitable zone overlap which maximizes the potential to support persistent life.The Field NarrowsRelationship between the stellar mass and location of the boundaries of the traditional and UV habitable zones for a star of one hundredth solar metallicity. The traditional and UV habitable zones do not overlap for stars of any mass. [Adapted from Oishi and Kamaya 2016]Oishi and Kamaya find that taking the UV habitable zone into account unsurprisingly decreases the places where persistent life might be found. For solar-metallicity stars, for instance, only those stars between 1.01.5 solar masses even have overlapping traditional and UV habitable zones.As metallicity of the host star decreases, the overlapping regions decrease as well: at a metallicity of one hundredth that of the Sun (Z=0.0002), the UV and traditional habitable zones do not overlap for any mass star.The authors point out that this does not necessarily mean that such stars cant support life. Stellar activity such as flares and coronal mass ejections can temporarily increase UV flux, possibly providing enough to make up for low steady-state flux. And oceans on planetary surfaces could shield potential life from UV flux that is too high.Nonetheless, the estimates of the UV habitable zone in this study help us to narrow down the most probableplaces for findinglife in the universe.CitationMidori Oishi and Hideyuki Kamaya 2016 ApJ 833 293. doi:10.3847/1538-4357/833/2/293

Defense Acquisitions. Missile Defense Agency Fields Initial Capability but Falls Short of Original Goals

DTIC Science & Technology

2006-03-01

Implementation Plan MAP Missile Defense System Assurance Provisions MDA Missile Defense System NASA National Aeronautics and Space Administration NFIRE ...fourth element, KEI, also delayed some activities related to its Near Field Infrared Experiment ( NFIRE ), which is being conducted to gather data on the...to complete a number of tasks that would have enabled it to conduct the NFIRE experiment. The experiment places sensors aboard a satellite that

Development of System Architecture to Investigate the Impact of Integrated Air and Missile Defense in a Distributed Lethality Environment

DTIC Science & Technology

2017-12-01

SYSTEM ARCHITECTURE TO INVESTIGATE THE IMPACT OF INTEGRATED AIR AND MISSILE DEFENSE IN A DISTRIBUTED LETHALITY ENVIRONMENT by Justin K. Davis...TO INVESTIGATE THE IMPACT OF INTEGRATED AIR AND MISSILE DEFENSE IN A DISTRIBUTED LETHALITY ENVIRONMENT 5. FUNDING NUMBERS 6. AUTHOR(S) Justin K...ARCHITECTURE TO INVESTIGATE THE IMPACT OF INTEGRATED AIR AND MISSILE DEFENSE IN A DISTRIBUTED LETHALITY ENVIRONMENT Justin K. Davis Lieutenant

The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches.

PubMed

Richards, Christopher; Albin, John S; Demir, Özlem; Shaban, Nadine M; Luengas, Elizabeth M; Land, Allison M; Anderson, Brett D; Holten, John R; Anderson, John S; Harki, Daniel A; Amaro, Rommie E; Harris, Reuben S

2015-12-01

APOBEC3 family DNA cytosine deaminases provide overlapping defenses against pathogen infections. However, most viruses have elaborate evasion mechanisms such as the HIV-1 Vif protein, which subverts cellular CBF-β and a polyubiquitin ligase complex to neutralize these enzymes. Despite advances in APOBEC3 and Vif biology, a full understanding of this direct host-pathogen conflict has been elusive. We combine virus adaptation and computational studies to interrogate the APOBEC3F-Vif interface and build a robust structural model. A recurring compensatory amino acid substitution from adaptation experiments provided an initial docking constraint, and microsecond molecular dynamic simulations optimized interface contacts. Virus infectivity experiments validated a long-lasting electrostatic interaction between APOBEC3F E289 and HIV-1 Vif R15. Taken together with mutagenesis results, we propose a wobble model to explain how HIV-1 Vif has evolved to bind different APOBEC3 enzymes and, more generally, how pathogens may evolve to escape innate host defenses. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription.

PubMed

Akay, Alper; Di Domenico, Tomas; Suen, Kin M; Nabih, Amena; Parada, Guillermo E; Larance, Mark; Medhi, Ragini; Berkyurek, Ahmet C; Zhang, Xinlian; Wedeles, Christopher J; Rudolph, Konrad L M; Engelhardt, Jan; Hemberg, Martin; Ma, Ping; Lamond, Angus I; Claycomb, Julie M; Miska, Eric A

2017-08-07

Small RNAs play a crucial role in genome defense against transposable elements and guide Argonaute proteins to nascent RNA transcripts to induce co-transcriptional gene silencing. However, the molecular basis of this process remains unknown. Here, we identify the conserved RNA helicase Aquarius/EMB-4 as a direct and essential link between small RNA pathways and the transcriptional machinery in Caenorhabditis elegans. Aquarius physically interacts with the germline Argonaute HRDE-1. Aquarius is required to initiate small-RNA-induced heritable gene silencing. HRDE-1 and Aquarius silence overlapping sets of genes and transposable elements. Surprisingly, removal of introns from a target gene abolishes the requirement for Aquarius, but not HRDE-1, for small RNA-dependent gene silencing. We conclude that Aquarius allows small RNA pathways to compete for access to nascent transcripts undergoing co-transcriptional splicing in order to detect and silence transposable elements. Thus, Aquarius and HRDE-1 act as gatekeepers coordinating gene expression and genome defense. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Cloud Overlapping Detection Algorithm Using Solar and IR Wavelengths With GOSE Data Over ARM/SGP Site

NASA Technical Reports Server (NTRS)

Kawamoto, Kazuaki; Minnis, Patrick; Smith, William L., Jr.

2001-01-01

One of the most perplexing problems in satellite cloud remote sensing is the overlapping of cloud layers. Although most techniques assume a 1-layer cloud system in a given retrieval of cloud properties, many observations are affected by radiation from more than one cloud layer. As such, cloud overlap can cause errors in the retrieval of many properties including cloud height, optical depth, phase, and particle size. A variety of methods have been developed to identify overlapped clouds in a given satellite imager pixel. Baum el al. (1995) used CO2 slicing and a spatial coherence method to demonstrate a possible analysis method for nighttime detection of multilayered clouds. Jin and Rossow (1997) also used a multispectral CO2 slicing technique for a global analysis of overlapped cloud amount. Lin et al. (1999) used a combination infrared, visible, and microwave data to detect overlapped clouds over water. Recently, Baum and Spinhirne (2000) proposed 1.6 and 11 microns. bispectral threshold method. While all of these methods have made progress in solving this stubborn problem, none have yet proven satisfactory for continuous and consistent monitoring of multilayer cloud systems. It is clear that detection of overlapping clouds from passive instruments such as satellite radiometers is in an immature stage of development and requires additional research. Overlapped cloud systems also affect the retrievals of cloud properties over the ARM domains (e.g., Minnis et al 1998) and hence should identified as accurately as possible. To reach this goal, it is necessary to determine which information can be exploited for detecting multilayered clouds from operational meteorological satellite data used by ARM. This paper examines the potential information available in spectral data available on the Geostationary Operational Environmental Satellite (GOES) imager and the NOAA Advanced Very High Resolution Radiometer (AVHRR) used over the ARM SGP and NSA sites to study the capability of detecting overlapping clouds

Cloud Overlapping Detection Algorithm Using Solar and IR Wavelengths with GOES Data Over ARM/SGP Site

NASA Technical Reports Server (NTRS)

Kawamoto, K.; Minnis, P.; Smith, W. L., Jr.

2001-01-01

One of the most perplexing problems in satellite cloud remote sensing is the overlapping of cloud layers. Although most techniques assume a one layer cloud system in a given retrieval of cloud properties, many observations are affected by radiation from more than one cloud layer. As such, cloud overlap can cause errors in the retrieval of many properties including cloud height, optical depth, phase, and particle size. A variety of methods have been developed to identify overlapped clouds in a given satellite imager pixel. Baum et al used CO2 slicing and a spatial coherence method to demonstrate a possible analysis method for nighttime detection of multilayered clouds. Jin and Rossow also used a multispectral CO2 slicing technique for a global analysis of overlapped cloud amount. Lin et al. used a combination infrared (IR), visible (VIS), and microwave data to detect overlapped clouds over water. Recently, Baum and Spinhirne proposed a 1.6 and 11 micron bispectral threshold method. While all of these methods have made progress in solving this stubborn problem none have yet proven satisfactory for continuous and consistent monitoring of multilayer cloud systems. It is clear that detection of overlapping clouds from passive instruments such as satellite radiometers is in an immature stage of development and requires additional research. Overlapped cloud systems also affect the retrievals of cloud properties over the Atmospheric Radiation Measurement (ARM) domains and hence should be identified as accurately as possible. To reach this goal, it is necessary to determine which information can be exploited for detecting multilayered clouds from operational meteorological satellite data used by ARM. This paper examines the potential information available in spectral data available on the Geostationary Operational Environmental Satellite (GOES) imager and the National Oceanic Atmospheric Administration (NOAA) Advanced Very High Resolution Radiometer (AVHRR) used over the ARM Program's Southern Great Plains (SGP), and North Slope of Alaska (NSA) sites to study the capability of detecting overlapping clouds.

75 FR 13095 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

... DEPARTMENT OF DEFENSE Department of the Air Force [Docket ID: USAF-2010-0007] Privacy Act of 1974... Federal Register Liaison Officer, Department of Defense. F031 AF SF B System Name: Security Forces... all Active Duty Military personnel, Reserve and Guard; Department of Defense (DoD) civilians and...

78 FR 45185 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-26

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DoD-2013-OS-0166] Privacy Act of 1974.... FOR FURTHER INFORMATION CONTACT: Mark Dorgan, DoD IG FOIA/Privacy Office, Department of Defense... OSD Federal Register Liaison Officer, Department of Defense. CIG-16 System name: DoD Hotline Program...

32 CFR 1602.14 - Local board.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Local board. 1602.14 Section 1602.14 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.14 Local board. A local board or a panel thereof of the Selective Service System is a group of not less...

32 CFR 1602.14 - Local board.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Local board. 1602.14 Section 1602.14 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.14 Local board. A local board or a panel thereof of the Selective Service System is a group of not less...

32 CFR 701.128 - Exemptions for specific Navy record systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Exemptions for specific Navy record systems. 701.128 Section 701.128 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND...

77 FR 40863 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-11

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2012-OS-0085] Privacy Act of 1974... Register Liaison Officer, Department of Defense. QNRO-31 System name: Software Security Risk Evaluations... the Department of Defense; DoDD 5240.2, DoD Counterintelligence (CI); DoDI 5240.8, Security...

32 CFR 701.128 - Exemptions for specific Navy record systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Exemptions for specific Navy record systems. 701.128 Section 701.128 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND...

32 CFR 701.128 - Exemptions for specific Navy record systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Exemptions for specific Navy record systems. 701.128 Section 701.128 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND...

32 CFR 701.128 - Exemptions for specific Navy record systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 5 2011-07-01 2011-07-01 false Exemptions for specific Navy record systems. 701.128 Section 701.128 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND...

75 FR 32635 - Defense Acquisition Regulations System; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... Regulations System; Defense Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption... implement the exemption from the Balance of Payments Program for construction material that is commercial... is proposing to amend the DFARS to implement in the clauses at 252.225-7044, Balance of Payments...

32 CFR 651.7 - Delegation of authority for non-acquisition systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Delegation of authority for non-acquisition systems. 651.7 Section 651.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Introduction § 651.7...

Discrete Event Simulation of a Suppression of Enemy Air Defenses (SEAD) Mission

DTIC Science & Technology

2008-03-01

component-based DES developed in Java® using the Simkit simulation package. Analysis of ship self air defense system selection ( Turan , 1999) is another...Institute of Technology, Wright-Patterson AFB OH, March 2003 (ADA445279 ) Turan , Bulent. A Comparative Analysis of Ship Self Air Defense (SSAD) Systems

48 CFR 252.225-7040 - Contractor Personnel Authorized to Accompany U.S. Armed Forces Deployed Outside the United States.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-7040 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252... Department of Defense. (o) Mortuary affairs. Mortuary affairs for Contractor personnel who die while...

48 CFR 252.225-7040 - Contractor Personnel Authorized to Accompany U.S. Armed Forces Deployed Outside the United States.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-7040 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252... Department of Defense. (o) Mortuary affairs. Mortuary affairs for Contractor personnel who die while...

48 CFR 252.225-7040 - Contractor Personnel Authorized to Accompany U.S. Armed Forces Deployed Outside the United States.

Code of Federal Regulations, 2013 CFR

2013-10-01

...-7040 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252... Department of Defense. (o) Mortuary affairs. Mortuary affairs for Contractor personnel who die while...

48 CFR 252.225-7040 - Contractor Personnel Authorized to Accompany U.S. Armed Forces Deployed Outside the United States.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-7040 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252... Department of Defense. (o) Mortuary affairs. Mortuary affairs for Contractor personnel who die while...

78 FR 35609 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-13

... DEPARTMENT OF DEFENSE Department of the Navy [Docket ID USN-2013-0018] Privacy Act of 1974; System... 10, 2013. Aaron Siegel, Alternate OSD Federal Register Liaison Officer, Department of Defense. N06110... of Social Security Number (SSN), Department of Defense Identification Number (DoD ID Number), Unit...

75 FR 22562 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2010-OS-0057] Privacy Act of 1974... Federal Register Liaison Officer, Department of Defense. S335.01 System name: Training and Employee... training funded or sponsored by the Defense Logistics Agency (DLA) to include DLA employees, Department of...

48 CFR 18.202 - Defense or recovery from certain attacks.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Defense or recovery from certain attacks. 18.202 Section 18.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency Acquisition Flexibilities 18.202 Defense or recovery from certain...

High-Throughput Identification of Antimicrobial Peptides from Amphibious Mudskippers

PubMed Central

You, Xinxin; Bian, Chao; Chen, Shixi; Lv, Zhao; Qiu, Limei; Shi, Qiong

2017-01-01

Widespread existence of antimicrobial peptides (AMPs) has been reported in various animals with comprehensive biological activities, which is consistent with the important roles of AMPs as the first line of host defense system. However, no big-data-based analysis on AMPs from any fish species is available. In this study, we identified 507 AMP transcripts on the basis of our previously reported genomes and transcriptomes of two representative amphibious mudskippers, Boleophthalmus pectinirostris (BP) and Periophthalmus magnuspinnatus (PM). The former is predominantly aquatic with less time out of water, while the latter is primarily terrestrial with extended periods of time on land. Within these identified AMPs, 449 sequences are novel; 15 were reported in BP previously; 48 are identically overlapped between BP and PM; 94 were validated by mass spectrometry. Moreover, most AMPs presented differential tissue transcription patterns in the two mudskippers. Interestingly, we discovered two AMPs, hemoglobin β1 and amylin, with high inhibitions on Micrococcus luteus. In conclusion, our high-throughput screening strategy based on genomic and transcriptomic data opens an efficient pathway to discover new antimicrobial peptides for ongoing development of marine drugs. PMID:29165344

High-Throughput Identification of Antimicrobial Peptides from Amphibious Mudskippers.

PubMed

Yi, Yunhai; You, Xinxin; Bian, Chao; Chen, Shixi; Lv, Zhao; Qiu, Limei; Shi, Qiong

2017-11-22

Widespread existence of antimicrobial peptides (AMPs) has been reported in various animals with comprehensive biological activities, which is consistent with the important roles of AMPs as the first line of host defense system. However, no big-data-based analysis on AMPs from any fish species is available. In this study, we identified 507 AMP transcripts on the basis of our previously reported genomes and transcriptomes of two representative amphibious mudskippers, Boleophthalmus pectinirostris (BP) and Periophthalmus magnuspinnatus (PM). The former is predominantly aquatic with less time out of water, while the latter is primarily terrestrial with extended periods of time on land. Within these identified AMPs, 449 sequences are novel; 15 were reported in BP previously; 48 are identically overlapped between BP and PM; 94 were validated by mass spectrometry. Moreover, most AMPs presented differential tissue transcription patterns in the two mudskippers. Interestingly, we discovered two AMPs, hemoglobin β1 and amylin, with high inhibitions on Micrococcus luteus . In conclusion, our high-throughput screening strategy based on genomic and transcriptomic data opens an efficient pathway to discover new antimicrobial peptides for ongoing development of marine drugs.

48 CFR 245.105 - Contractor's property management system compliance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... management system compliance. 245.105 Section 245.105 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.105 Contractor's property management system compliance. The assigned property administrator shall perform...

Defense Occupational and Environmental Health Readiness System (DOEHRS) Guidance

DTIC Science & Technology

2009-07-01

TERMS Defense Occupational and Environmental Health Reporting System (DOEHRS), Industrial Hygiene, Environmental Health, Information Management System Hygiene...Information System (AF EMIS), the Air Force Enterprise Environmental, Safety, and Occupational Health Information Management System (EESOH MIS), or the

Defense Systems Management Review. Volume I, Number 4. Autumn 1977

DTIC Science & Technology

1977-10-03

quarterly by the Defense Systems Management College, Fort Belvoir, VA 22060. Publication of the Review was approved by OASD(PA) May 18 1976. The views...Two copies of reprinted material should be forwarded to the Editor. Distribution of this publication is controlled. Inquiries concerning...DESTBIBUTION STATEMENT A Approved for public release; ■Distribution Unlimited in DEFENSE SYSTEMS MANAGEMENT REVIEW PURPOSE The purpose of the

Defense AT&L Magazine: A Publication of the Defense Acquisition University. Volume 34, Number 3, DAU 184

DTIC Science & Technology

2005-01-01

developed a partnership with the Defense Acquisition University to in- tegrate DISA’s systems engineering processes, software , and network...in place, with processes being implemented: deployment management; systems engineering ; software engineering ; configuration man- agement; test and...CSS systems engineering is a transition partner with Carnegie Mellon University’s Software Engineering Insti- tute and its work on the capability

Reconstruction of the evolution of microbial defense systems.

PubMed

Puigbò, Pere; Makarova, Kira S; Kristensen, David M; Wolf, Yuri I; Koonin, Eugene V

2017-04-04

Evolution of bacterial and archaeal genomes is a highly dynamic process that involves intensive loss of genes as well as gene gain via horizontal transfer, with a lesser contribution from gene duplication. The rates of these processes can be estimated by comparing genomes that are linked by an evolutionary tree. These estimated rates of genome dynamics events substantially differ for different functional classes of genes. The genes involved in defense against viruses and other invading DNA are among those that are gained and lost at the highest rates. We employed a stochastic birth-and-death model to obtain maximum likelihood estimates of the rates of gain and loss of defense genes in 35 groups of closely related bacterial genomes and one group of archaeal genomes. We find that on average, the defense genes experience 1.4 fold higher flux than the rest of microbial genes. This excessive flux of defense genes over the genomic mean is consistent across diverse microbial groups. The few exceptions include intracellular parasites with small, degraded genomes that possess few defense systems which are more stable than in other microbes. Generally, defense genes follow the previously established pattern of genome dynamics, with gene family loss being about 3 times more common than gain and an order of magnitude more common than expansion or contraction of gene families. Case by case analysis of the evolutionary dynamics of defense genes indicates frequent multiple events in the same locus and widespread involvement of mobile elements in the gain and loss of defense genes. Evolution of microbial defense systems is highly dynamic but, notwithstanding the host-parasite arms race, generally follows the same trends that have been established for the rest of the genes. Apart from the paucity and the low flux of defense genes in parasitic bacteria with deteriorating genomes, there is no clear connection between the evolutionary regime of defense systems and microbial life style.

76 FR 71823 - Defense Federal Acquisition Regulation Supplement: Responsibility and Liability for Government...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... Vol. 76 Friday, No. 223 November 18, 2011 Part V Department of Defense Defense Acquisition Regulation System 48 CFR Parts 202, 203, 211, et al. Defense Federal Acquisition Regulation Supplements... Regulations#0;#0; [[Page 71824

76 FR 35424 - Information Collection Requirements; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System Information Collection Requirements; Defense Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Contracts AGENCY..., Construction and Architect-Engineer Contracts, and Related Clauses at DFARS 252.236; OMB Control Number 0704...

75 FR 45104 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0225] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Administrative Matters... Supplement (DFARS) Part 204, Administrative Matters, and related clauses at DFARS 252.204; DD Form 2051...

76 FR 20336 - Defense Audit Advisory Committee (DAAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... DEPARTMENT OF DEFENSE Office of the Secretary Defense Audit Advisory Committee (DAAC) AGENCY... following Federal advisory committee meeting of the Defense Audit Advisory Committee will be held. DATES... management to include financial reporting processes, systems of internal controls, audit processes, and...

77 FR 74834 - Office of the Secretary

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-18

... DEPARTMENT OF DEFENSE Office of the Secretary Defense Audit Advisory Committee (DAAC); Notice of... Defense announces the following Federal advisory committee meeting of the Defense Audit Advisory Committee... financial management to include financial reporting processes, systems of internal controls, audit processes...

Program Manager: The Journal of the Defense Systems Management College. Volume 15, Number 4, July-August 1986.

DTIC Science & Technology

1986-08-01

Architect, troi systems, CAD CAM, and com- functional analysis , synthesis, and National Bureau of Standards, mon engineering data bases will be the trade...Recurrent analysis of a management these s h e m evolutionary chain of data processing problem combining real data and ponents of defense support system...at the Defense first constructed his support simulator Systems Management College, the by assembling appropriate analysis Data Storage and Retrieval

Dollar Summary of Federal Supply Classification and Service Category by Company, FY83, Part 4 (AA92-N063).

DTIC Science & Technology

1983-01-01

INTEGRATED SYSTEMS ANALYSTS INC VIRGINIA NAVY RDTE/ELECTRONICS AND COMMUNICATION EQUIP 964 INTERACTIVE SYSTEMS INC MICHIGAN USAF ROTE/ELECTRONICS AND...HARD GOODS INTERACTIVE SYSTEMS INC COLORADO ARMY RDTE/MISCELLANEOUS HARD GOODS LITTON SYSTEMS INC NEW JERSEY NAVY RDTE/MISCELLANEOUS HARD GOODS I...DEFENSE 88 INTELLIGENT SY STATE TOTAL 114 INTERACTIVE TE CO CALIFORNIA ARMY RDTE/OTHER DEFENSE 201 INTERNATIONAL I NAVY ROTE/OTHER DEFENSE 778 USAF RDTE

Transcriptome and Metabolite Profiling of the Infection Cycle of Zymoseptoria tritici on Wheat Reveals a Biphasic Interaction with Plant Immunity Involving Differential Pathogen Chromosomal Contributions and a Variation on the Hemibiotrophic Lifestyle Definition1[OPEN

PubMed Central

Rudd, Jason J.; Kanyuka, Kostya; Hassani-Pak, Keywan; Derbyshire, Mark; Andongabo, Ambrose; Devonshire, Jean; Lysenko, Artem; Saqi, Mansoor; Desai, Nalini M.; Powers, Stephen J.; Hooper, Juliet; Ambroso, Linda; Bharti, Arvind; Farmer, Andrew; Hammond-Kosack, Kim E.; Dietrich, Robert A.; Courbot, Mikael

2015-01-01

The hemibiotrophic fungus Zymoseptoria tritici causes Septoria tritici blotch disease of wheat (Triticum aestivum). Pathogen reproduction on wheat occurs without cell penetration, suggesting that dynamic and intimate intercellular communication occurs between fungus and plant throughout the disease cycle. We used deep RNA sequencing and metabolomics to investigate the physiology of plant and pathogen throughout an asexual reproductive cycle of Z. tritici on wheat leaves. Over 3,000 pathogen genes, more than 7,000 wheat genes, and more than 300 metabolites were differentially regulated. Intriguingly, individual fungal chromosomes contributed unequally to the overall gene expression changes. Early transcriptional down-regulation of putative host defense genes was detected in inoculated leaves. There was little evidence for fungal nutrient acquisition from the plant throughout symptomless colonization by Z. tritici, which may instead be utilizing lipid and fatty acid stores for growth. However, the fungus then subsequently manipulated specific plant carbohydrates, including fructan metabolites, during the switch to necrotrophic growth and reproduction. This switch coincided with increased expression of jasmonic acid biosynthesis genes and large-scale activation of other plant defense responses. Fungal genes encoding putative secondary metabolite clusters and secreted effector proteins were identified with distinct infection phase-specific expression patterns, although functional analysis suggested that many have overlapping/redundant functions in virulence. The pathogenic lifestyle of Z. tritici on wheat revealed through this study, involving initial defense suppression by a slow-growing extracellular and nutritionally limited pathogen followed by defense (hyper) activation during reproduction, reveals a subtle modification of the conceptual definition of hemibiotrophic plant infection. PMID:25596183

Signal signature and transcriptome changes of Arabidopsis during pathogen and insect attack.

PubMed

De Vos, Martin; Van Oosten, Vivian R; Van Poecke, Remco M P; Van Pelt, Johan A; Pozo, Maria J; Mueller, Martin J; Buchala, Antony J; Métraux, Jean-Pierre; Van Loon, L C; Dicke, Marcel; Pieterse, Corné M J

2005-09-01

Plant defenses against pathogens and insects are regulated differentially by cross-communicating signaling pathways in which salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) play key roles. To understand how plants integrate pathogen- and insect-induced signals into specific defense responses, we monitored the dynamics of SA, JA, and ET signaling in Arabidopsis after attack by a set of microbial pathogens and herbivorous insects with different modes of attack. Arabidopsis plants were exposed to a pathogenic leaf bacterium (Pseudomonas syringae pv. tomato), a pathogenic leaf fungus (Alternaria brassicicola), tissue-chewing caterpillars (Pieris rapae), cell-content-feeding thrips (Frankliniella occidentalis), or phloem-feeding aphids (Myzus persicae). Monitoring the signal signature in each plant-attacker combination showed that the kinetics of SA, JA, and ET production varies greatly in both quantity and timing. Analysis of global gene expression profiles demonstrated that the signal signature characteristic of each Arabidopsis-attacker combination is orchestrated into a surprisingly complex set of transcriptional alterations in which, in all cases, stress-related genes are overrepresented. Comparison of the transcript profiles revealed that consistent changes induced by pathogens and insects with very different modes of attack can show considerable overlap. Of all consistent changes induced by A. brassicicola, Pieris rapae, and E occidentalis, more than 50% also were induced consistently by P. syringae. Notably, although these four attackers all stimulated JA biosynthesis, the majority of the changes in JA-responsive gene expression were attacker specific. All together, our study shows that SA, JA, and ET play a primary role in the orchestration of the plant's defense response, but other regulatory mechanisms, such as pathway cross-talk or additional attacker-induced signals, eventually shape the highly complex attacker-specific defense response.

FUNCTIONAL OVERLAP OF ROOT SYSTEMS IN AN OLD-GROWTH FOREST INFERRED FROM TRACER 15N UPTAKE

EPA Science Inventory

Belowground competition for nutrients and water is considered a key factor affecting spatial organization and productivity of individual stems within forest stands, yet there are few data describing the lateral extent and overlap of competing root systems. We quantified the func...

77 FR 43477 - Defense Federal Acquisition Regulation Supplement: Ownership of Offeror (DFARS Case 2011-D044)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-24

... DEPARTMENT OF DEFENSE 48 CFR Parts 204, 212, and 252 RIN 0750-AH58 Defense Federal Acquisition Regulation Supplement: Ownership of Offeror (DFARS Case 2011-D044) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Proposed rule. SUMMARY: DoD is proposing to amend the...

32 CFR Appendix A to Part 323 - Instructions for Preparation of System Notices

Code of Federal Regulations, 2011 CFR

2011-07-01

... DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM Pt. 323, App. A Appendix A to... Copies may be obtained from the Defense Logistics Agency, ATTN: DSS-CV, 8725 John J. Kingman Road, Suite... Secretary of Defense has issued DoD Directive 5105.22 (32 CFR part 398), Defense Logistics Agency (DLA), the...

32 CFR Appendix A to Part 323 - Instructions for Preparation of System Notices

Code of Federal Regulations, 2012 CFR

2012-07-01

... DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM Pt. 323, App. A Appendix A to... Copies may be obtained from the Defense Logistics Agency, ATTN: DSS-CV, 8725 John J. Kingman Road, Suite... Secretary of Defense has issued DoD Directive 5105.22 (32 CFR part 398), Defense Logistics Agency (DLA), the...

32 CFR Appendix A to Part 323 - Instructions for Preparation of System Notices

Code of Federal Regulations, 2010 CFR

2010-07-01

... DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM Pt. 323, App. A Appendix A to... Copies may be obtained from the Defense Logistics Agency, ATTN: DSS-CV, 8725 John J. Kingman Road, Suite... Secretary of Defense has issued DoD Directive 5105.22 (32 CFR part 398), Defense Logistics Agency (DLA), the...

Directed Energy Technology Working Group Report (IDA/OSD R&M (Institute for Defense Analyses/Office of the Secretary of Defense Reliability and Maintainability) Study).

DTIC Science & Technology

1983-08-01

Missile (SLBM) Defense Scenario ............................................ B-1 C Space-Based Anti-Ballistic Missile ( ABM ) Defense Scenario...Ballistic Missile (SLBM) Defense Scenario, and at Strategic Space-Based Anti-Ballistic Missile ( ABM ) Defense Scenario. These case studies are provided...of flight. 3.5.3 Spaced-Based ABM Defense Scenario In this scenario, an orbiting battle station is operating as an element of GBMD System, and it is

76 FR 35421 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2011-OS-0064] Privacy Act of 1974..., 2011. Aaron Siegel, Alternate OSD Federal Register Liaison Officer, Department of Defense. DHRA 06.... SUMMARY: The Office of the Secretary of Defense proposes to alter a system of records in its inventory of...

32 CFR Appendix H to Part 323 - DLA Exemption Rules

Code of Federal Regulations, 2011 CFR

2011-07-01

... PROGRAM DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM Pt. 323, App. H Appendix H to Part 323—DLA Exemption... systems of records maintained by the Defense Logistics Agency will be exempt from the requirements of 5 U... Defense Logistics Agency claims the same exemptions for the records from those “other” systems that are...

48 CFR 222.101-3-70 - Impact of labor disputes on defense programs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Impact of labor disputes... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Basic Labor Policies 222.101-3-70 Impact of labor disputes on defense programs. (a...

32 CFR 806b.30 - Evaluating information systems for Privacy Act compliance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Evaluating information systems for Privacy Act compliance. 806b.30 Section 806b.30 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR... privacy issues are unchanged. (d) The depth and content of the Privacy Impact Assessment should be...

32 CFR 806b.30 - Evaluating information systems for Privacy Act compliance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Evaluating information systems for Privacy Act compliance. 806b.30 Section 806b.30 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR... privacy issues are unchanged. (d) The depth and content of the Privacy Impact Assessment should be...

Goldwater-Nichols at 30: Defense Reform and Issues for Congress

DTIC Science & Technology

2016-06-02

observers maintain that a reform of the broader interagency system on national security matters is needed. Despite these disagreements, several...Taken together, however, the issues raised by these questions suggest the systemic nature of the challenges with which the Department of Defense...External Defense Expert Reform Proposals ............................................................................ 24 Formulating Requirements

77 FR 4629 - Defense Federal Acquisition Regulation Supplement; Trade Agreements Thresholds (DFARS Case 2012...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-30

... Vol. 77 Monday, No. 19 January 30, 2012 Part II Department of Defense Defense Acquisitions Regulations System 48 CFR Part 212, 225, 231, et al. Defense Federal Acquisition Regulation Supplements; Final... and Regulations#0;#0; [[Page 4630

48 CFR 5452.249 - Allocation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 5452.249 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE... Fuel Supply Center is authorized to use the following clause in domestic and overseas petroleum... Defense that the Defense Fuel Supply Center be provided contract volumes exceeding the pro rata amount of...

48 CFR 5452.249 - Allocation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Section 5452.249 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE... Fuel Supply Center is authorized to use the following clause in domestic and overseas petroleum... Defense that the Defense Fuel Supply Center be provided contract volumes exceeding the pro rata amount of...

48 CFR 5452.249 - Allocation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Section 5452.249 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE... Fuel Supply Center is authorized to use the following clause in domestic and overseas petroleum... Defense that the Defense Fuel Supply Center be provided contract volumes exceeding the pro rata amount of...

48 CFR 5452.249 - Allocation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 5452.249 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE... Fuel Supply Center is authorized to use the following clause in domestic and overseas petroleum... Defense that the Defense Fuel Supply Center be provided contract volumes exceeding the pro rata amount of...

48 CFR 5452.249 - Allocation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 5452.249 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE... Fuel Supply Center is authorized to use the following clause in domestic and overseas petroleum... Defense that the Defense Fuel Supply Center be provided contract volumes exceeding the pro rata amount of...

76 FR 13297 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

... 215 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System... Director, Defense Procurement and Acquisition Policy. DATES: Effective Date: March 11, 2011. Applicability... adding a section at 215.300 with a reference to Director, Defense Procurement and Acquisition Policy...

32 CFR 1285.5 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS DEFENSE LOGISTICS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 1285.5 Procedures. (a) FOIA channels. If DLA personnel... office, they will immediately forward it to the local FOIA manager. (b) Central log system. Each FOIA...

Defense Inventory: Further Analysis and Enhanced Metrics Could Improve Service Supply and Depot Operations

DTIC Science & Technology

2016-06-01

of and replace. DOD maintains weapon systems (e.g., aircraft and ships) and equipment (e.g., generators and radars) that require regular and...including helicopters, combat vehicles, air defense systems, ships, fighter and bomber aircraft , intercontinental ballistic missiles, jet aircraft ...Defense for Acquisition, Technology, and Logistics. 19In the depot maintenance context, an end item can be a weapon system, such as an aircraft , ship

Semantic Web and Inferencing Technologies for Department of Defense Systems

DTIC Science & Technology

2014-10-01

contact report for a specific type of aircraft . Intra-domain-specific metadata in the threat data domain might be used to categorize the contact...DEFENSE SYSTEMS by Duane Davis October 2014 Approved for public release; distribution is unlimited Prepared for: The NPS Center for Multi-INT...TITLE AND SUBTITLE Semantic Web and Inferencing Technologies for Department of Defense Systems 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

DoD Source Selection: Competencies, Deficiencies, and Remedies

DTIC Science & Technology

2014-04-30

University, Ministry of National Defense, Republic of China Strategic Planning and Management in Defense Systems Acquisition Stanley Rosen, Defense... systems procurement officer. He was employed in purchasing management for prime contractors on NASA’s Hubble Space Telescope, DoE’s Positron Electron...was living the good life, “he … was squandering precious tax dollars for, among other things, systems the military didn’t ask for, didn’t need and

48 CFR 234.003 - Responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Responsibilities. 234.003 Section 234.003 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION 234.003 Responsibilities. DoDD...

75 FR 30003 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

...; System of Records AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice to delete a system of records. SUMMARY: The Defense Intelligence Agency proposes to delete a system of records notice in its existing...) 231-1193. [[Page 30004

48 CFR 225.7003-2 - Restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 225.7003-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Authorization Acts, Appropriations Acts, and...) Missile or space systems. (3) Ships. (4) Tank or automotive items. (5) Weapon systems. (6) Ammunition. (b...

48 CFR 225.7003-2 - Restrictions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Section 225.7003-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Authorization Acts, Appropriations Acts, and...) Missile or space systems. (3) Ships. (4) Tank or automotive items. (5) Weapon systems. (6) Ammunition. (b...

48 CFR 225.7003-2 - Restrictions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 225.7003-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Authorization Acts, Appropriations Acts, and...) Missile or space systems. (3) Ships. (4) Tank or automotive items. (5) Weapon systems. (6) Ammunition. (b...

48 CFR 225.7003-2 - Restrictions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Section 225.7003-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Authorization Acts, Appropriations Acts, and...) Missile or space systems. (3) Ships. (4) Tank or automotive items. (5) Weapon systems. (6) Ammunition. (b...

48 CFR 225.7003-2 - Restrictions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 225.7003-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Authorization Acts, Appropriations Acts, and...) Missile or space systems. (3) Ships. (4) Tank or automotive items. (5) Weapon systems. (6) Ammunition. (b...

48 CFR 201.301 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Policy. 201.301 Section 201.301 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Agency Acquisition Regulations 201.301 Policy. (a...

The Future Role of the Department of Defense in Protecting and Defending America’s Economy in Cyberspace

DTIC Science & Technology

2014-12-12

hold. The retail giant installed a FireEye computer security system that completed a month long testing phase in May 2013. The system was designed ...agencies. Through the Untied States Cyber Command, the Department of Defense has capability that can be used to defend America. This reseach paper looks... reseach paper looks at the roles and responsibilities of the Department of Defense as it relates to Homeland Defense and the protection of credit

Evaluation of the DEIMS (Defense Economic Impact Modeling System) System.

DTIC Science & Technology

1984-07-01

AOORESS(H d~fereet m Caii~dl Offiee) IS. SECURITY CLASS. (of Wd e~w Vr OUSDRE (DoD-IDA Management Office) UCASFE 1801 N. Beauregard Street UCASFE...Defense Spending Mr. Paul Dickens, PA&E Labor Demand - Dr. David Blond Conclusion - Dr. David L. Mdicol 11:00 Break SESSION III - IMPACT OF DEFENSE...presented highlights of the industrial and labor impact of defense spending during. . 1985-89. Mr. Paul Dickens then analysed trends in the I- .""L- " ’•L

Harnessing the Prokaryotic Adaptive Immune System as a Eukaryotic Antiviral Defense

PubMed Central

Price, Aryn A.; Grakoui, Arash; Weiss, David S.

2016-01-01

Clustered, regularly interspaced, short palindromic repeats - CRISPR associated (CRISPR-Cas) systems are sequence specific RNA-directed endonuclease complexes that bind and cleave nucleic acids. These systems evolved within prokaryotes as adaptive immune defenses to target and degrade nucleic acids derived from bacteriophages and other foreign genetic elements. The antiviral function of these systems has now been exploited to combat eukaryotic viruses throughout the viral life cycle. Here we discuss current advances in CRISPR-Cas9 technology as a eukaryotic antiviral defense. PMID:26852268

Plant innate immunity: an updated insight into defense mechanism.

PubMed

Muthamilarasan, Mehanathan; Prasad, Manoj

2013-06-01

Plants are invaded by an array of pathogens of which only a few succeed in causing disease. The attack by others is countered by a sophisticated immune system possessed by the plants. The plant immune system is broadly divided into two, viz. microbial-associated molecular-patterns-triggered immunity (MTI) and effector-triggered immunity (ETI). MTI confers basal resistance, while ETI confers durable resistance, often resulting in hypersensitive response. Plants also possess systemic acquired resistance (SAR), which provides long-term defense against a broad-spectrum of pathogens. Salicylic-acid-mediated systemic acquired immunity provokes the defense response throughout the plant system during pathogen infection at a particular site. Trans-generational immune priming allows the plant to heritably shield their progeny towards pathogens previously encountered. Plants circumvent the viral infection through RNA interference phenomena by utilizing small RNAs. This review summarizes the molecular mechanisms of plant immune system, and the latest breakthroughs reported in plant defense. We discuss the plant–pathogen interactions and integrated defense responses in the context of presenting an integral understanding in plant molecular immunity.

32 CFR 320.12 - Exemptions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Exemptions. 320.12 Section 320.12 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL GEOSPATIAL-INTELLIGENCE AGENCY (NGA) PRIVACY § 320.12 Exemptions. (a) Exempt systems of record...

32 CFR 320.12 - Exemptions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Exemptions. 320.12 Section 320.12 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM NATIONAL GEOSPATIAL-INTELLIGENCE AGENCY (NGA) PRIVACY § 320.12 Exemptions. (a) Exempt systems of record...

32 CFR 287.2 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Applicability. This part applies to DISA and the Office of the Manager, National Communications System (OMNCS). ... 32 National Defense 2 2012-07-01 2012-07-01 false Applicability. 287.2 Section 287.2 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF...

32 CFR 287.2 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Applicability. This part applies to DISA and the Office of the Manager, National Communications System (OMNCS). ... 32 National Defense 2 2013-07-01 2013-07-01 false Applicability. 287.2 Section 287.2 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF...

32 CFR 287.2 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Applicability. This part applies to DISA and the Office of the Manager, National Communications System (OMNCS). ... 32 National Defense 2 2010-07-01 2010-07-01 false Applicability. 287.2 Section 287.2 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF...

32 CFR 287.2 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Applicability. This part applies to DISA and the Office of the Manager, National Communications System (OMNCS). ... 32 National Defense 2 2011-07-01 2011-07-01 false Applicability. 287.2 Section 287.2 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF...

32 CFR 287.2 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Applicability. This part applies to DISA and the Office of the Manager, National Communications System (OMNCS). ... 32 National Defense 2 2014-07-01 2014-07-01 false Applicability. 287.2 Section 287.2 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF...