Substance Abuse Counselors and Moral Reasoning: Hypothetical and Authentic Dilemmas

ERIC Educational Resources Information Center

Sias, Shari M.

2009-01-01

This exploratory study examined the assumption that the level of moral reasoning (Defining Issues Test; J. R. Rest, 1986) used in solving hypothetical and authentic dilemmas is similar for substance abuse counselors (N = 188). The statistical analyses used were paired-sample t tests, Pearson product-moment correlation, and simultaneous multiple…

Invisible Wars: Iraq, Afghanistan, and Teaching Insurgencies in Public Schools

ERIC Educational Resources Information Center

Doyle, Christopher L.

2012-01-01

This author contends that contemporary issues classes no longer have currency, as standardized test results are the litmus test for education. In many schools, students are isolated from firsthand accounts and formal study of events that textbooks will one day proclaim as defining experiences of their generation. According to Doyle, schools tend…

Space Construction Experiment Definition Study (SCEDS), part 2. Volume 2: Study results

NASA Technical Reports Server (NTRS)

1982-01-01

The Space Construction Experiment (SCE) was defined for integration into the Space Shuttle. This included development of flight assignment data, revision and update of preliminary mission timelines and test plans, analysis of flight safety issues, and definition of ground operations scenarios. New requirements for the flight experiment and changes for a large space antenna feed mask test article were incorporated. The program plan and cost estimates were updated. Revised SCE structural dynamics characteristics were provided for simulation and analysis of experimental tests to define and verify control limits and interactions effects between the SCE and the Orbiter digital automatic pilot.

STGT program: Ada coding and architecture lessons learned

NASA Technical Reports Server (NTRS)

Usavage, Paul; Nagurney, Don

1992-01-01

STGT (Second TDRSS Ground Terminal) is currently halfway through the System Integration Test phase (Level 4 Testing). To date, many software architecture and Ada language issues have been encountered and solved. This paper, which is the transcript of a presentation at the 3 Dec. meeting, attempts to define these lessons plus others learned regarding software project management and risk management issues, training, performance, reuse, and reliability. Observations are included regarding the use of particular Ada coding constructs, software architecture trade-offs during the prototyping, development and testing stages of the project, and dangers inherent in parallel or concurrent systems, software, hardware, and operations engineering.

Developing Moral Maturity: An Evaluation of the Media Ethics Course Using the DIT-2

ERIC Educational Resources Information Center

Auger, Giselle A.; Gee, Charlie

2016-01-01

The purpose of this study was to add to the limited body of knowledge on the effect of the media ethics course, specifically to investigate the effect of the course on the growth in moral judgment reasoning of students through a quasi-experimental pre-test, post-test analysis using the Defining Issues Test 2 (DIT-2). Results demonstrated…

TRAN-STAT: statistics for environmental transuranic studies, July 1978, Number 5

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This issue is concerned with nonparametric procedures for (1) estimating the central tendency of a population, (2) describing data sets through estimating percentiles, (3) estimating confidence limits for the median and other percentiles, (4) estimating tolerance limits and associated numbers of samples, and (5) tests of significance and associated procedures for a variety of testing situations (counterparts to t-tests and analysis of variance). Some characteristics of several nonparametric tests are illustrated using the NAEG /sup 241/Am aliquot data presented and discussed in the April issue of TRAN-STAT. Some of the statistical terms used here are defined in a glossary. Themore » reference list also includes short descriptions of nonparametric books. 31 references, 3 figures, 1 table.« less

The Engineering and Science Issues Test (ESIT): a discipline-specific approach to assessing moral judgment.

PubMed

Borenstein, Jason; Drake, Matthew J; Kirkman, Robert; Swann, Julie L

2010-06-01

To assess ethics pedagogy in science and engineering, we developed a new tool called the Engineering and Science Issues Test (ESIT). ESIT measures moral judgment in a manner similar to the Defining Issues Test, second edition, but is built around technical dilemmas in science and engineering. We used a quasi-experimental approach with pre- and post-tests, and we compared the results to those of a control group with no overt ethics instruction. Our findings are that several (but not all) stand-alone classes showed a significant improvement compared to the control group when the metric includes multiple stages of moral development. We also found that the written test had a higher response rate and sensitivity to pedagogy than the electronic version. We do not find significant differences on pre-test scores with respect to age, education level, gender or political leanings, but we do on whether subjects were native English speakers. We did not find significant differences on pre-test scores based on whether subjects had previous ethics instruction; this could suggest a lack of a long-term effect from the instruction.

Assessing Medical Students' Moral Judgment over the Course of a Four-Year Professionalism and Humanism Curriculum

ERIC Educational Resources Information Center

Riegle, Sandra E.; Frye, Ann W.; Glenn, Jason; Smith, Kirk L.

2012-01-01

Teachers tasked with developing moral character in future physicians face an array of pedagogic challenges, among them identifying tools to measure progress in instilling the requisite skill set. One validated instrument for assessing moral judgment is the Defining Issues Test (DIT-2). Based on the work of Lawrence Kohlberg, the test's main…

The Development of Moral Reasoning and Perceptions of Parental Behavior in Students from Kuwait.

ERIC Educational Resources Information Center

Gielen, Uwe P.; And Others

1992-01-01

Presents a study in which students from Kuwait were given Rest's Defining Issues Test (DIT) to measure the development of moral judgment skills. Explains that results were compared with scales measuring student perception of parental behavior. Concludes that the DIT may not be a valid test for development of moral judgment in an Arab culture. (DK)

Thinking About Thinking: Enhancing Creativity and Understanding in Operational Planners

DTIC Science & Technology

2012-06-08

34An Experimental Method for Measuring the Emergence,” 462. 19Arthur J. Cropley , “Defining and Measuring Creativity: Are Creativity Tests Worth Using...Creativity and Affect in Fantasy in Children”, Creativity Research Journal Volume 12, Issue 2 (1999): 134; Cropley , 72. 117Helson, Ravenna Helson, “A...Longitudinal Study of Creative Personality in Women,” Creativity Research Journal Volume 12, Issue 2 (1999): 89; Cropley , 78. 118Lubart, “Models of

Tests of Theories of Crime in Female Prisoners.

PubMed

Lindberg, Marc A; Fugett, April; Adkins, Ashtin; Cook, Kelsey

2017-02-01

Several general theories of crime were tested with path models on 293 female prisoners in a U.S. State prison. The theories tested included Social Bond and Control, Thrill/Risk Seeking, and a new attachment-based Developmental Dynamic Systems model. A large battery of different instruments ranging from measures of risk taking, to a crime addiction scale, to Childhood Adverse Events, to attachments and clinical issues were used. The older general theories of crime did not hold up well under the rigor of path modeling. The new dynamic systems model was supported that incorporated adverse childhood events leading to (a) peer crime, (b) crime addiction, and (c) a measure derived from the Attachment and Clinical Issues Questionnaire (ACIQ) that takes individual differences in attachments and clinical issues into account. The results were discussed in terms of new approaches to Research Defined Criteria of Diagnosis (RDoC) and new approaches to intervention.

Inspiration or Infringement: Parody and the Law.

ERIC Educational Resources Information Center

Hannabuss, Stuart

2002-01-01

Examines some of the literary and legal implications of parody. Highlights include defining parody; legal and ethical issues, including copyright infringement; moral rights and wrongs; parody and fair use; the four-factor test regarding copyright; relevant court cases; and postmodern consequences, including authenticity. (LRW)

Can Ethics Be Taught? A Quasi-Experimental Study of the Impact of Class Size on the Cognitive Moral Reasoning of Freshmen Business Students

ERIC Educational Resources Information Center

Sullivan, Ethan A.

2011-01-01

The purpose of this study was to determine the impact of a business ethics course on the cognitive moral reasoning of freshmen business students. The sample consisted of 268 college students enrolled in a required business ethics course. The students took Rest's Defining Issues Test--Version 2 (DIT2) as a pre-test and then post-test (upon…

Direction and Integration of Experimental Ground Test Capabilities and Computational Methods

NASA Technical Reports Server (NTRS)

Dunn, Steven C.

2016-01-01

This paper groups and summarizes the salient points and findings from two AIAA conference panels targeted at defining the direction, with associated key issues and recommendations, for the integration of experimental ground testing and computational methods. Each panel session utilized rapporteurs to capture comments from both the panel members and the audience. Additionally, a virtual panel of several experts were consulted between the two sessions and their comments were also captured. The information is organized into three time-based groupings, as well as by subject area. These panel sessions were designed to provide guidance to both researchers/developers and experimental/computational service providers in defining the future of ground testing, which will be inextricably integrated with the advancement of computational tools.

School Psychological Services and Program Evaluation

ERIC Educational Resources Information Center

MacGregor, Mary Jo, Ed.

1972-01-01

A variety of court decisions and laws relevant to malpractice and liability of school psychologists are presented. Terms are defined and examples of faulty psychological testing, defamation, withholding information, and inferred imcompetence are provided. Suggestions regarding litigation and legal defenses are made and issues related to…

Software Defined Networking challenges and future direction: A case study of implementing SDN features on OpenStack private cloud

NASA Astrophysics Data System (ADS)

Shamugam, Veeramani; Murray, I.; Leong, J. A.; Sidhu, Amandeep S.

2016-03-01

Cloud computing provides services on demand instantly, such as access to network infrastructure consisting of computing hardware, operating systems, network storage, database and applications. Network usage and demands are growing at a very fast rate and to meet the current requirements, there is a need for automatic infrastructure scaling. Traditional networks are difficult to automate because of the distributed nature of their decision making process for switching or routing which are collocated on the same device. Managing complex environments using traditional networks is time-consuming and expensive, especially in the case of generating virtual machines, migration and network configuration. To mitigate the challenges, network operations require efficient, flexible, agile and scalable software defined networks (SDN). This paper discuss various issues in SDN and suggests how to mitigate the network management related issues. A private cloud prototype test bed was setup to implement the SDN on the OpenStack platform to test and evaluate the various network performances provided by the various configurations.

Accountability and the Struggle over What Counts.

ERIC Educational Resources Information Center

Theobald, Paul; Mills, Ed

1995-01-01

Discusses issues defining the boundaries of the current accountability debate, focusing on the historical struggle between the ideas of philosopher John Dewey and psychologist Edward Thorndike. In the Thorndike camp, corporate America wants educators to continue to sort, select, and label children, aided by standardized testing. The…

Goethe's Faust Revisited: Lessons from DIT Research.

ERIC Educational Resources Information Center

Nucci, Larry

2002-01-01

Discusses the Defining Issues Test as an invaluable tool for research and practice in moral education. Explains that because such instruments are based upon previous developmental research, they are unsuitable for research on moral development. Argues that these measures stand in the way of generating new knowledge. (CAJ)

77 FR 34129 - Heavy-Duty Highway Program: Revisions for Emergency Vehicles

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-08

... diesel vehicles, including emergency vehicles. Some control system designs and implementation strategies... broad engine families and vehicle test groups that are defined by similar emissions and performance... public safety issue related to design of engines and emission control systems on emergency vehicles that...

Changing Moral Judgement in Divinity Students

ERIC Educational Resources Information Center

Bunch, Wilton H.

2005-01-01

Gains in moral judgement, as measured by the Defining Issues Test (DIT), correlate strongly with advancing education. Curricula that are strongly biblically based may not promote, and students with a strong fundamentalist orientation may not demonstrate, such moral growth. Students at an interdenominational, but very conservative seminary,…

Styles of Parent-Child Interaction and Moral Reasoning in Adolescence.

ERIC Educational Resources Information Center

Boyes, Michael C.; Allen, Sandra G.

1993-01-01

Examined whether adolescents of authoritative parents exhibit a greater preference for postconventional moral reasoning than do adolescents of permissive or authoritarian parents. Subjects (75 high school and 67 undergraduate students) completed Rest's Defining Issues Test and Schaefer's Child Report of Parental Behavior Inventory. Results…

Local Equating Using the Rasch Model, the OPLM, and the 2PL IRT Model--or--What Is It Anyway if the Model Captures Everything There Is to Know about the Test Takers?

ERIC Educational Resources Information Center

von Davier, Matthias; González B., Jorge; von Davier, Alina A.

2013-01-01

Local equating (LE) is based on Lord's criterion of equity. It defines a family of true transformations that aim at the ideal of equitable equating. van der Linden (this issue) offers a detailed discussion of common issues in observed-score equating relative to this local approach. By assuming an underlying item response theory model, one of…

Space station structures and dynamics test program

NASA Technical Reports Server (NTRS)

Moore, Carleton J.; Townsend, John S.; Ivey, Edward W.

1987-01-01

The design, construction, and operation of a low-Earth orbit space station poses unique challenges for development and implementation of new technology. The technology arises from the special requirement that the station be built and constructed to function in a weightless environment, where static loads are minimal and secondary to system dynamics and control problems. One specific challenge confronting NASA is the development of a dynamics test program for: (1) defining space station design requirements, and (2) identifying the characterizing phenomena affecting the station's design and development. A general definition of the space station dynamic test program, as proposed by MSFC, forms the subject of this report. The test proposal is a comprehensive structural dynamics program to be launched in support of the space station. The test program will help to define the key issues and/or problems inherent to large space structure analysis, design, and testing. Development of a parametric data base and verification of the math models and analytical analysis tools necessary for engineering support of the station's design, construction, and operation provide the impetus for the dynamics test program. The philosophy is to integrate dynamics into the design phase through extensive ground testing and analytical ground simulations of generic systems, prototype elements, and subassemblies. On-orbit testing of the station will also be used to define its capability.

Multiplicity

DTIC Science & Technology

1991-04-01

that it has not adopted that test. 1 3 5 The Court did, however, recognize that the double Jeopardy protection includes a collateral estoppel feature... estoppel feature. 1 4 1 The Court articulated this new test in the following terms: The Double Jeopardy Clause bars any subsequent prosecution in which...126 Ashe v. Swenson, 397 U.S. at 452 (Brennan, J., concurring). 127 "We defined collateral estoppel as providing that ’when an issue of ultimate

An Empirical Investigation of the Moral Judgment Development of a Sample of High School Kuwaiti Teachers

ERIC Educational Resources Information Center

Al-Shurai, Saad

2012-01-01

This study was conducted to investigate the moral development of one hundred Kuwaiti high school teachers. They ranged in age from 23 to 48 years with a mean of 28.6 years and a standard deviation of 8.3 years. The teachers' individual moral judgment levels were assessed by the Defining Issues Test (DIT)--an objective test designed by James Rest…

Measuring Well What is Ill Defined?

ERIC Educational Resources Information Center

Torres Irribarra, David

2017-01-01

Maul's paper, "Rethinking Traditional Methods of Survey Validation," is a clever and pointed indictment of a set of specific but widespread practices in psychological measurement and the social sciences at large. Through it, Maul highlights central issues in the way to approach theory building and theory testing, bringing to mind the…

Gifted Children's Perception of Divorce.

ERIC Educational Resources Information Center

Falk, Carolyn

1987-01-01

The perceptions of divorce in 41 gifted and regular students (grades 5-8) were compared through interviews, writing samples, and the Defining Issues test. Gifted students gave longer stories, more readily took the perspective of adults, showed a stronger desire to understand reasons for divorce, and displayed more advanced moral reasoning.…

Do Ethics Classes Teach Ethics?

ERIC Educational Resources Information Center

Curzer, Howard J.; Sattler, Sabrina; DuPree, Devin G.; Smith-Genthôs, K. Rachelle

2014-01-01

The ethics assessment industry is currently dominated by the second version of the Defining Issues Test (DIT2). In this article, we describe an alternative assessment instrument called the Sphere-Specific Moral Reasoning and Theory Survey (SMARTS), which measures the respondent's level of moral development in several respects. We describe eight…

Issues in Education: Last Stand for Teacher Education

ERIC Educational Resources Information Center

Fischetti, John C.

2013-01-01

In this brief article, the author argues that if society defines schools as testing centers instead of learning centers where young people go to watch adults work, then teacher education programs are replaceable. Online technologies allow for the transmittal of information without the need for traditional classroom settings. However, if schools…

A Study of Moral Reasoning Development of Teacher Education Students in Northern Louisiana

ERIC Educational Resources Information Center

Wade, April Mitchell

2015-01-01

This quantitative descriptive study identified the differences in the moral reasoning development levels between undergraduate teacher education students enrolled in methods courses and graduate teacher education students enrolled in an alternative certification education program using the Defining Issues Test-2 instrument. Based on Kohlberg's…

Experimental control in software reliability certification

NASA Technical Reports Server (NTRS)

Trammell, Carmen J.; Poore, Jesse H.

1994-01-01

There is growing interest in software 'certification', i.e., confirmation that software has performed satisfactorily under a defined certification protocol. Regulatory agencies, customers, and prospective reusers all want assurance that a defined product standard has been met. In other industries, products are typically certified under protocols in which random samples of the product are drawn, tests characteristic of operational use are applied, analytical or statistical inferences are made, and products meeting a standard are 'certified' as fit for use. A warranty statement is often issued upon satisfactory completion of a certification protocol. This paper outlines specific engineering practices that must be used to preserve the validity of the statistical certification testing protocol. The assumptions associated with a statistical experiment are given, and their implications for statistical testing of software are described.

Process for Selecting System Level Assessments for Human System Technologies

NASA Technical Reports Server (NTRS)

Watts, James; Park, John

2006-01-01

The integration of many life support systems necessary to construct a stable habitat is difficult. The correct identification of the appropriate technologies and corresponding interfaces is an exhaustive process. Once technologies are selected secondary issues such as mechanical and electrical interfaces must be addressed. The required analytical and testing work must be approached in a piecewise fashion to achieve timely results. A repeatable process has been developed to identify and prioritize system level assessments and testing needs. This Assessment Selection Process has been defined to assess cross cutting integration issues on topics at the system or component levels. Assessments are used to identify risks, encourage future actions to mitigate risks, or spur further studies.

Indexes of severity: conceptual development.

PubMed Central

Krischer, J P

1979-01-01

A discussion of severity index development is presented in relation to conceptual issues in index definition, analytic issues in index formulation and validation issues in index application. The CHOP index is discussed along with six severity indexes described in an earlier paper dealing with underlying concepts to illustrate the material presented. Replies are provided to specific questions raised in an accompanying paper discussing the Injury Severity Score. This conceptual material is presented to provide a foundation for severity index development, to suggest criteria to be used in their formulation and testing, and to identify analyses that can lead to the successful selection and application of an index for a defined purpose. PMID:468553

Learning to think strategically.

PubMed

1994-01-01

Strategic thinking focuses on issues that directly affect the ability of a family planning program to attract and retain clients. This issue of "The Family Planning Manager" outlines the five steps of strategic thinking in family planning administration: 1) define the organization's mission and strategic goals; 2) identify opportunities for improving quality, expanding access, and increasing demand; 3) evaluate each option in terms of its compatibility with the organization's goals; 4) select an option; and 5) transform strategies into action. Also included in this issue is a 20-question test designed to permit readers to assess their "strategic thinking quotient" and a list of sample questions to guide a strategic analysis.

Forcible Rape: An Analysis of Legal Issues.

ERIC Educational Resources Information Center

National Inst. of Law Enforcement and Criminal Justice (Dept. of Justice/LEAA), Washington, DC.

Traditionally, rape has been defined as "carnal knowledge of a woman by force and against her will." The test of force has been crucial, and consent deduced. Victims were assumed to be consenting parties unless criminal circumstances could be proved. Victims were oftened questioned about past sexual behavior. Current reform efforts have attempted…

Arrested Development? Comparing Educational Leadership Students with National Norms on Moral Reasoning

ERIC Educational Resources Information Center

Greer, Jennifer L.; Searby, Linda J.; Thoma, Stephen J.

2015-01-01

Purpose: The public expects school leaders to be moral exemplars, yet prior research indicates that teachers and, more recently, school principals may score lower than other career groups on a widely used measure of moral reasoning, the Defining Issues Test. Moreover, little empirical research has been conducted on educators during leadership…

Between Kohlberg and Gilligan: Levels of Moral Judgment among Elementary School Principals

ERIC Educational Resources Information Center

Vitton, Charles J.; Wasonga, Teresa A.

2009-01-01

This research investigated levels of moral judgment among public elementary school principals as measured by the Defining Issues Test Version 2 for occupationally relevant and other moral dilemmas. The participants scored lower (38.7) than the predicted average P score (postconventional thinking) for individuals who have attained graduate level…

Moral Development and Social Worker Ethical Decision-Making

ERIC Educational Resources Information Center

Groessl, Joan

2013-01-01

This study examined both the moral development levels using the Defining Issues Test-2 (DIT--2) and ethical decision-making using the Professional Opinion Scale (POS) of social workers who provide field supervision to students within accredited social work programs in Wisconsin. Using the moral development theory of Kohlberg (1981) which defined…

Human perceptual deficits as factors in computer interface test and evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bowser, S.E.

1992-06-01

Issues related to testing and evaluating human computer interfaces are usually based on the machine rather than on the human portion of the computer interface. Perceptual characteristics of the expected user are rarely investigated, and interface designers ignore known population perceptual limitations. For these reasons, environmental impacts on the equipment will more likely be defined than will user perceptual characteristics. The investigation of user population characteristics is most often directed toward intellectual abilities and anthropometry. This problem is compounded by the fact that some deficits capabilities tend to be found in higher-than-overall population distribution in some user groups. The testmore » and evaluation community can address the issue from two primary aspects. First, assessing user characteristics should be extended to include tests of perceptual capability. Secondly, interface designs should use multimode information coding.« less

Traceability validation of a high speed short-pulse testing method used in LED production

NASA Astrophysics Data System (ADS)

Revtova, Elena; Vuelban, Edgar Moreno; Zhao, Dongsheng; Brenkman, Jacques; Ulden, Henk

2017-12-01

Industrial processes of LED (light-emitting diode) production include LED light output performance testing. Most of them are monitored and controlled by optically, electrically and thermally measuring LEDs by high speed short-pulse measurement methods. However, these are not standardized and a lot of information is proprietary that it is impossible for third parties, such as NMIs, to trace and validate. It is known, that these techniques have traceability issue and metrological inadequacies. Often due to these, the claimed performance specifications of LEDs are overstated, which consequently results to manufacturers experiencing customers' dissatisfaction and a large percentage of failures in daily use of LEDs. In this research a traceable setup is developed to validate one of the high speed testing techniques, investigate inadequacies and work out the traceability issues. A well-characterised short square pulse of 25 ms is applied to chip-on-board (CoB) LED modules to investigate the light output and colour content. We conclude that the short-pulse method is very efficient in case a well-defined electrical current pulse is applied and the stabilization time of the device is "a priori" accurately determined. No colour shift is observed. The largest contributors to the measurement uncertainty include badly-defined current pulse and inaccurate calibration factor.

Gun Testing Ballistics Issues for Insensitive Munitions Fragment Impact Testing

NASA Astrophysics Data System (ADS)

Baker, Ernest; Schultz, Emmanuel; NATO Munitions Safety Information Analysis Centre Team

2017-06-01

The STANAG 4496 Ed. 1 Fragment Impact, Munitions Test Procedure is normally conducted by gun launching a projectile for attack against a munition. The purpose of this test is to assess the reaction of a munition impacted by a fragment. The test specifies a standardized projectile (fragment) with a standard test velocity of 2530+/-90 m/s, or an alternate test velocity of 1830+/-60 m/s. The standard test velocity can be challenging to achieve and has several loosely defined and undefined characteristics that can affect the test item response. This publication documents the results of an international review of the STANAG 4496 related to the fragment impact test. To perform the review, MSIAC created a questionnaire in conjunction with the custodian of this STANAG and sent it to test centers. Fragment velocity variation, projectile tilt upon impact and aim point variation were identified as observed gun testing issues. Achieving 2530 m/s consistently and cost effectively can be challenging. The aim point of impact of the fragment is chosen with the objective of obtaining the most violent reaction. No tolerance for aim point is specified, although aim point variation can be a source for IM response variation. Fragment tilt on impact is also unspecified. The standard fragment fabricated from a variety of different steels which have a significant margin for mechanical properties. These, as well as other gun testing issues, have significant implications to resulting IM response.

NASA flight cell and battery issues

NASA Technical Reports Server (NTRS)

Schulze, N. R.

1989-01-01

The author presents the important battery and cell problems, encompassing both test failures and accidents, which were encountered during the past year. Practical issues facing programs, which have to be considered in the development of a battery program strategy, are addressed. The problems of one program, the GRO (Gamma Ray Observatory), during the past year are focused on to illustrate the fundamental types of battery problems that occur. Problems encountered by other programs are briefly mentioned to complete the accounting. Two major categories of issues are defined, namely, whose which are quality and design related, i.e., problems having inherent manufacturing-process-related aspects with an impact on cell reliability, and these which are accident triggered or man induced, i.e., those operational issues having an impact on battery and cell reliability.

The Relationship between Ethical Decision Making and Ethical Reasoning in Information Technology Students

ERIC Educational Resources Information Center

Woodward, Belle; Davis, Diane C.; Hodis, Flaviu A.

2007-01-01

This study examined undergraduate information technology (IT) students' (N = 122) level of ethical reasoning and decision making at a Midwestern university. The purpose was to determine whether IT students' level of ethical reasoning provided information about the degree of their ethical decision making. The Defining Issues Test-2 (DIT-2) was used…

The Effect of Personal Orientations toward Intergroup Relations on Moral Reasoning

ERIC Educational Resources Information Center

Passini, Stefano

2014-01-01

This article examined how the group membership of the person being judged influenced the level of moral reasoning. Nearly 200 ordinary Italians were given two measures of moral ingroup inclusiveness (the Bogardus social distance scale and a self-categorization measure) and the short form of Rest's Defining Issues Test (DIT). The protagonists in…

How Does PISA Assess Science Literacy? PISA in Focus. No. 66

ERIC Educational Resources Information Center

OECD Publishing, 2016

2016-01-01

The most recent round of the assessment, PISA 2015, focused on 15-year-olds' science literacy, defined as "the ability to engage with science-related issues, and with the ideas of science, as a reflective citizen". To succeed on the PISA science test, students had to display their mastery of three skills: explaining phenomena…

Moral Judgement Changes among Undergraduates in a Capstone Internship Experience

ERIC Educational Resources Information Center

Craig, Patricia J.; Oja, Sharon Nodie

2013-01-01

This mixed-methods study explored the moral growth of undergraduates in a recreation management internship experience. The quantitative phase reported moral judgement gains in Personal Interest and Post-conventional schema, and N-2 scores, as measured by the Defining Issues Test 2 (DIT-2), among 33 interns. The case-study method used a pattern…

A new test of computational protein design: predicting posttranslational modification specificity for the enzyme SMYD2.

PubMed

Reynolds, Kimberly A

2015-01-06

In this issue of Structure, Lanouette and colleagues use a combination of computation and experiment to define a specificity motif for the lysine methyltransferase SMYD2. Using this motif, they predict and experimentally verify four new SMYD2 substrates. Copyright © 2015 Elsevier Ltd. All rights reserved.

Exploring the Relationship between Academic Dishonesty and Moral Development in Law School Students

ERIC Educational Resources Information Center

Edmondson, Macey Lynd

2013-01-01

This mixed methods study explored whether a relationship existed between moral development and dishonest academic behaviors in law students. The quantitative portion of the study utilized a survey adapted from James Rest's Defining Issues Test and Donald McCabe's Academic Integrity Survey. Law students were solicited by email from two public…

The Accountability System: Defining Responsibility for Student Achievement. Children Achieving: Philadelphia's Education Reform. Progress Report Series 1996-1997.

ERIC Educational Resources Information Center

Luhm, Theresa; Foley, Ellen; Corcoran, Tom

This report explores issues related to accountability in the context of Children Achieving, the school reform effort of Philadelphia (Pennsylvania). The accountability system begins with content standards in English/language arts, mathematics, science, and the arts. The Stanford-9 Achievement Test has been designated to assess how students are…

The Moral Reasoning of Sports Management Students in the United States and Italy

ERIC Educational Resources Information Center

Forte, Almerinda

2013-01-01

The researcher analyzed the moral reasoning ability of Sports Management students in the United States and Italy. The researcher statistically analyzed data collected through a survey questionnaire designed to measure moral reasoning. The Defining Issues Test (DIT) developed by James Rest using Kohlberg's six stages of moral judgment was used in…

A Review of Methodological Issues in the Differential Diagnosis of Autism Spectrum Disorders in Children

ERIC Educational Resources Information Center

Matson, Johnny L.; Nebel-Schwalm, Marie; Matson, Michael L.

2007-01-01

The development of standardized tests to assess autism, particularly in young children, is a topic of considerable interest in the research community. Recent years have seen an exponential growth in scales for differential diagnosis. Particular emphasis has been placed on defining and better delineating the symptoms of the disorder relative to…

Validation of cell-based fluorescence assays: practice guidelines from the ICSH and ICCS - part II - preanalytical issues.

PubMed

Davis, Bruce H; Dasgupta, Amar; Kussick, Steven; Han, Jin-Yeong; Estrellado, Annalee

2013-01-01

Flow cytometry and other technologies of cell-based fluorescence assays are as a matter of good laboratory practice required to validate all assays, which when in clinical practice may pass through regulatory review processes using criteria often defined with a soluble analyte in plasma or serum samples in mind. Recently the U.S. Food and Drug Administration (FDA) has entered into a public dialogue in the U.S. regarding their regulatory interest in laboratory developed tests (LDTs) or so-called "home brew" assays performed in clinical laboratories. The absence of well-defined guidelines for validation of cell-based assays using fluorescence detection has thus become a subject of concern for the International Council for Standardization of Haematology (ICSH) and International Clinical Cytometry Society (ICCS). Accordingly, a group of over 40 international experts in the areas of test development, test validation, and clinical practice of a variety of assay types using flow cytometry and/or morphologic image analysis were invited to develop a set of practical guidelines useful to in vitro diagnostic (IVD) innovators, clinical laboratories, regulatory scientists, and laboratory inspectors. The focus of the group was restricted to fluorescence reporter reagents, although some common principles are shared by immunohistochemistry or immunocytochemistry techniques and noted where appropriate. The work product of this two year effort is the content of this special issue of this journal, which is published as 5 separate articles, this being Validation of Cell-based Fluorescence Assays: Practice Guidelines from the ICSH and ICCS - Part II - Preanalytical issues. © 2013 International Clinical Cytometry Society. © 2013 International Clinical Cytometry Society.

[Determination of blood alcohol among aviation personnel: proposed operative protocol].

PubMed

Lopez, A; Cardoni, F; Bova, M; Simonazzi, S; Romolo, F S; Ricciardi Tenore, G

2003-01-01

The problems of the use/abuse of alcohol need a special attention by the Public Authorities, based on the scientific evidences related to the subject. We would like to define in the present paper the procedures for alcohol testing (and drug testing) in the sailors, following the international aviation authorities (ICAO, JAR-OPS-1, FAA) recommendations. A Working Group was established to study both the scientific and the legal aspects of the problems related to alcohol testing in Italy. Experts from the Università "La Sapienza" and from Alitalia studied the alcohol testing issues abroad to set out criteria, guidelines and procedures for random testing in Italy.

A systems approach to solder joint fatigue in spacecraft electronic packaging

NASA Technical Reports Server (NTRS)

Ross, R. G., Jr.

1991-01-01

Differential expansion induced fatigue resulting from temperature cycling is a leading cause of solder joint failures in spacecraft. Achieving high reliability flight hardware requires that each element of the fatigue issue be addressed carefully. This includes defining the complete thermal-cycle environment to be experienced by the hardware, developing electronic packaging concepts that are consistent with the defined environments, and validating the completed designs with a thorough qualification and acceptance test program. This paper describes a useful systems approach to solder fatigue based principally on the fundamental log-strain versus log-cycles-to-failure behavior of fatigue. This fundamental behavior has been useful to integrate diverse ground test and flight operational thermal-cycle environments into a unified electronics design approach. Each element of the approach reflects both the mechanism physics that control solder fatigue, as well as the practical realities of the hardware build, test, delivery, and application cycle.

A Test of the Agenda-Setting Power of the Black Periodical Press: 1974-1982.

ERIC Educational Resources Information Center

Cherry, Dianne Lynne

Defining agenda-setting as the ability of the mass media to influence the level of the public's awareness and perceptions of political issues, a study was conducted to examine the agenda-setting power of the black periodical press in the United States. Survey responses collected by the University of Michigan Center for Political Studies were…

A Comparison of the Cognitive Moral Development of Christian University Seniors in Traditional versus Adult Degree Completion Programs

ERIC Educational Resources Information Center

Loomis, Michael J.

2009-01-01

This research uses the Defining Issues Test-2 (DIT-2) to investigate the cognitive moral development of college seniors in adult degree completion (ADC) programs and traditional undergraduate (TU) programs at three Council of Christian College and University institutions. Overall, TU students had significantly higher scores on the DIT-2, TU…

The Relationship Between Principled Moral Reasoning and Cheating Behavior under Threat and Nonthreat Situations.

ERIC Educational Resources Information Center

Leming, James S.

Based upon the theory of moral stages devised by educational psychologist Lawrence Kohlberg, this report examines the influence of the social situation on principled moral reasoning and on cheating. Research assessed the level of moral reasoning for 152 college juniors and seniors using Rest's Defining Issues Test (1976) in which levels of low,…

Modifying Defining Issues Test (DIT) as a Tool for Assessing Secondary Students' Social-Emotional Competencies

ERIC Educational Resources Information Center

Ee, Jessie

2014-01-01

This paper discusses the use of an alternative instrument to assess the social-emotional competence (SEC) of secondary school students in Singapore. The instrument was used in a larger study to explore an approach to infuse social-emotional learning in the curriculum for children in school. The design of this research instrument is based on the…

Resolution of an Orbital Issue: A Designed Experiment

NASA Technical Reports Server (NTRS)

Huddleston, Lisa L.

2011-01-01

Design of Experiments (DOE) is a systematic approach to investigation of a system or process. A series of structured tests are designed in which planned changes are made to the input variables of a process or system. The effects of these changes on a pre-defined output are then assessed. DOE is a formal method of maximizing information gained while minimizing resources required.

The Attitudes of Second-Year College Students: Exploring the Mindsets behind the "Sophomore Slump." 2013 Research Report

ERIC Educational Resources Information Center

Noel-Levitz, Inc., 2013

2013-01-01

In response to the growing call to increase college completion rates, many campus officials have turned their attention to the "sophomore slump"--a term that broadly defines the somewhat-common and lackluster performance of a substantial portion of second-year college students. To examine this issue, this report looks beyond test scores…

Computerized Neuropsychological Assessment Devices: Joint Position Paper of the American Academy of Clinical Neuropsychology and the National Academy of Neuropsychology†

PubMed Central

Bauer, Russell M.; Iverson, Grant L.; Cernich, Alison N.; Binder, Laurence M.; Ruff, Ronald M.; Naugle, Richard I.

2012-01-01

This joint position paper of the American Academy of Clinical Neuropsychology and the National Academy of Neuropsychology sets forth our position on appropriate standards and conventions for computerized neuropsychological assessment devices (CNADs). In this paper, we first define CNADs and distinguish them from examiner-administered neuropsychological instruments. We then set forth position statements on eight key issues relevant to the development and use of CNADs in the healthcare setting. These statements address (a) device marketing and performance claims made by developers of CNADs; (b) issues involved in appropriate end-users for administration and interpretation of CNADs; (c) technical (hardware/software/firmware) issues; (d) privacy, data security, identity verification, and testing environment; (e) psychometric development issues, especially reliability, and validity; (f) cultural, experiential, and disability factors affecting examinee interaction with CNADs; (g) use of computerized testing and reporting services; and (h) the need for checks on response validity and effort in the CNAD environment. This paper is intended to provide guidance for test developers and users of CNADs that will promote accurate and appropriate use of computerized tests in a way that maximizes clinical utility and minimizes risks of misuse. The positions taken in this paper are put forth with an eye toward balancing the need to make validated CNADs accessible to otherwise underserved patients with the need to ensure that such tests are developed and utilized competently, appropriately, and with due concern for patient welfare and quality of care. PMID:22382386

Computerized Neuropsychological Assessment Devices: Joint Position Paper of the American Academy of Clinical Neuropsychology and the National Academy of Neuropsychology†

PubMed Central

Bauer, Russell M.; Iverson, Grant L.; Cernich, Alison N.; Binder, Laurence M.; Ruff, Ronald M.; Naugle, Richard I.

2013-01-01

This joint position paper of the American Academy of Clinical Neuropsychology and the National Academy of Neuropsychology sets forth our position on appropriate standards and conventions for computerized neuropsychological assessment devices (CNADs). In this paper, we first define CNADs and distinguish them from examiner-administered neuropsychological instruments. We then set forth position statements on eight key issues relevant to the development and use of CNADs in the healthcare setting. These statements address (a) device marketing and performance claims made by developers of CNADs; (b) issues involved in appropriate end-users for administration and interpretation of CNADs; (c) technical (hardware/software/firmware) issues; (d) privacy, data security, identity verification, and testing environment; (e) psychometric development issues, especially reliability and validity; (f) cultural, experiential, and disability factors affecting examinee interaction with CNADs; (g) use of computerized testing and reporting services; and (h) the need for checks on response validity and effort in the CNAD environment. This paper is intended to provide guidance for test developers and users of CNADs that will promote accurate and appropriate use of computerized tests in a way that maximizes clinical utility and minimizes risks of misuse. The positions taken in this paper are put forth with an eye toward balancing the need to make validated CNADs accessible to otherwise underserved patients with the need to ensure that such tests are developed and utilized competently, appropriately, and with due concern for patient welfare and quality of care. PMID:22394228

It's about the Gateway Courses: Defining and Contextualizing the Issue

ERIC Educational Resources Information Center

Koch, Andrew K.

2017-01-01

This introductory chapter defines the phrase gateway courses, describes why these courses are one of the most compelling issues in the contemporary student success movement, and details what is at stake if the issues associated with these courses are left unaddressed.

Biometrics: A Look at Facial Recognition

DTIC Science & Technology

a facial recognition system in the city’s Oceanfront tourist area. The system has been tested and has recently been fully implemented. Senator...Kenneth W. Stolle, the Chairman of the Virginia State Crime Commission, established a Facial Recognition Technology Sub-Committee to examine the issue of... facial recognition technology. This briefing begins by defining biometrics and discussing examples of the technology. It then explains how biometrics

Rape Myth Acceptance, Hypermasculinity, and SAT Scores as Correlates of Moral Development: Understanding Sexually Aggressive Attitudes in First-Year College Men

ERIC Educational Resources Information Center

Tatum, Jerry L.; Foubert, John D.

2009-01-01

Male perpetrated sexual aggression has long been recognized as a serious problem on college campuses. The purpose of this multiple regression correlation study was to assess the relationship between levels of moral development (measured by the Defining Issues Test) and the degree to which first-year college men (N = 161) ascribed to rape…

Linguistic labels, dynamic visual features, and attention in infant category learning.

PubMed

Deng, Wei Sophia; Sloutsky, Vladimir M

2015-06-01

How do words affect categorization? According to some accounts, even early in development words are category markers and are different from other features. According to other accounts, early in development words are part of the input and are akin to other features. The current study addressed this issue by examining the role of words and dynamic visual features in category learning in 8- to 12-month-old infants. Infants were familiarized with exemplars from one category in a label-defined or motion-defined condition and then tested with prototypes from the studied category and from a novel contrast category. Eye-tracking results indicated that infants exhibited better category learning in the motion-defined condition than in the label-defined condition, and their attention was more distributed among different features when there was a dynamic visual feature compared with the label-defined condition. These results provide little evidence for the idea that linguistic labels are category markers that facilitate category learning. Copyright © 2015 Elsevier Inc. All rights reserved.

Linguistic Labels, Dynamic Visual Features, and Attention in Infant Category Learning

PubMed Central

Deng, Wei (Sophia); Sloutsky, Vladimir M.

2015-01-01

How do words affect categorization? According to some accounts, even early in development, words are category markers and are different from other features. According to other accounts, early in development, words are part of the input and are akin to other features. The current study addressed this issue by examining the role of words and dynamic visual features in category learning in 8- to 12- month infants. Infants were familiarized with exemplars from one category in a label-defined or motion-defined condition and then tested with prototypes from the studied category and from a novel contrast category. Eye tracking results indicated that infants exhibited better category learning in the motion-defined than in the label-defined condition and their attention was more distributed among different features when there was a dynamic visual feature compared to the label-defined condition. These results provide little evidence for the idea that linguistic labels are category markers that facilitate category learning. PMID:25819100

Defining and Measuring Engagement and Learning in Science: Conceptual, Theoretical, Methodological, and Analytical Issues

ERIC Educational Resources Information Center

Azevedo, Roger

2015-01-01

Engagement is one of the most widely misused and overgeneralized constructs found in the educational, learning, instructional, and psychological sciences. The articles in this special issue represent a wide range of traditions and highlight several key conceptual, theoretical, methodological, and analytical issues related to defining and measuring…

[Workers with alcohol and drug addiction problems. Consensus Document of the Study Group on Hazardous Workers].

PubMed

Magnavita, N; Bergamaschi, A; Chiarotti, M; Colombi, A; Deidda, B; De Lorenzo, G; Goggiamani, Angela; Magnavita, Giulia; Ricciardi, W; Sacco, A; Spagnolo, A G; Bevilacqua, Liliana; Brunati, Manuela Maria; Campanile, T; Cappai, M; Cicerone, Marina; Ciprani, F; Di Giannantonio, M; Di Martino, G; Fenudi, Laura; Garbarino, S; Lopez, Annunziata; Mammi, Francesca; Orsini, D; Ranalletta, Dalila; Simonazzi, S; Stanzani, C

2008-01-01

Italian Law 81/08 (so-called "Unified Text of Laws on Health and Safety at Work"), came into force on 15 May 2008 and incorporates provisions related to medical surveillance of drug and alcohol dependency at the workplace. Occupational health traditionally addresses the issue of protection of worker from occupational hazards. The issue of protection of third parties from behaviour of workers resulting from drug and alcohol dependency implies an original methodological approach, involving full cooperation of employer, employees, and health and safety consultants. A consensus development meeting was organized under the leadership of the Italian Study Group on Hazardous Workers (La.R.A. group). The meeting brought together physicians of different specialties, legal experts and bioethicists, labour and management policy-makers, to discuss the issue and define the research data available, the standards that were appropriate, and which policies were fair. The efficacy of medical surveillance, including workplace drug-testing, relies on a comprehensive policy, including written and verbal information on the use of alcohol and drugs on the job, training for supervisors and management, employee education, and employee assistance structures. Sample collection and testing should be carried out in accordance with standardized and tested procedures. Small businesses will need assistance, including development of model policies, setting up consortia for testing services and if necessary request for National Insurance benefits to reduce costs. The recently introduced Italian legislation on occupational safety and health closely resembles Finnish law since it consists of a "double channel" for workplace drug testing. At recruitment, the employer is entitled to ask a job applicant for a certificate of "Job fitness", including drug tests, that can be issued only by a public health institution, where the job applicant works on a well-defined set of tasks which require accuracy, trustworthiness, independent judgement or a very good reaction capacity. The employer may also refer the employee to the public health institution to obtain a certificate in the course of an employment contract when there is a legitimate suspicion that the employee is working while under the effects of drugs or alcohol or that the employee is a drug addict. After recruitment, the physician responsible for medical surveillance of workers (the so-called "Competent Physician") is entitled to perform drug tests on employees. The need for a test is decided by the health care professional, not by the employer, and only a general report on the health of the employee ("fit", fit with restrictions" or "unfit") may be given to the employer. Workers positive for drug tests will be referred to a public health institution for re-testing and treatment.

Virtual Shaker Testing: Simulation Technology Improves Vibration Test Performance

NASA Technical Reports Server (NTRS)

Ricci, Stefano; Peeters, Bart; Fetter, Rebecca; Boland, Doug; Debille, Jan

2008-01-01

In the field of vibration testing, the interaction between the structure being tested and the instrumentation hardware used to perform the test is a critical issue. This is particularly true when testing massive structures (e.g. satellites), because due to physical design and manufacturing limits, the dynamics of the testing facility often couples with the test specimen one in the frequency range of interest. A further issue in this field is the standard use of a closed loop real-time vibration control scheme, which could potentially shift poles and change damping of the aforementioned coupled system. Virtual shaker testing is a novel approach to deal with these issues. It means performing a simulation which closely represents the real vibration test on the specific facility by taking into account all parameters which might impact the dynamic behavior of the specimen. In this paper, such a virtual shaker testing approach is developed. It consists of the following components: (1) Either a physical-based or an equation-based coupled electro-mechanical lumped parameter shaker model is created. The model parameters are obtained from manufacturer's specifications or by carrying out some dedicated experiments; (2) Existing real-time vibration control algorithm are ported to the virtual simulation environment; and (3) A structural model of the test object is created and after defining proper interface conditions structural modes are computed by means of the well-established Craig-Bampton CMS technique. At this stage, a virtual shaker test has been run, by coupling the three described models (shaker, control loop, structure) in a co-simulation routine. Numerical results have eventually been correlated with experimental ones in order to assess the robustness of the proposed methodology.

Study of utilization of advanced composites in fuselage structures of large transports

NASA Technical Reports Server (NTRS)

Jackson, A. C.; Campion, M. C.; Pei, G.

1984-01-01

The effort required by the transport aircraft manufacturers to support the introduction of advanced composite materials into the fuselage structure of future commercial and military transport aircraft is investigated. Technology issues, potential benefits to military life cycle costs and commercial operating costs, and development plans are examined. The most urgent technology issues defined are impact dynamics, acoustic transmission, pressure containment and damage tolerance, post-buckling, cutouts, and joints and splices. A technology demonstration program is defined and a rough cost and schedule identified. The fabrication and test of a full-scale fuselage barrel section is presented. Commercial and military benefits are identified. Fuselage structure weight savings from use of advanced composites are 16.4 percent for the commercial and 21.8 percent for the military. For the all-composite airplanes the savings are 26 percent and 29 percent, respectively. Commercial/operating costs are reduced by 5 percent for the all-composite airplane and military life cycle costs by 10 percent.

Analysis of small crack behavior for airframe applications

NASA Technical Reports Server (NTRS)

Mcclung, R. C.; Chan, K. S.; Hudak, S. J., Jr.; Davidson, D. L.

1994-01-01

The small fatigue crack problem is critically reviewed from the perspective of airframe applications. Different types of small cracks-microstructural, mechanical, and chemical-are carefully defined and relevant mechanisms identified. Appropriate analysis techniques, including both rigorous scientific and practical engineering treatments, are briefly described. Important materials data issues are addressed, including increased scatter in small crack data and recommended small crack test methods. Key problems requiring further study are highlighted.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gauglitz, Phillip A.; Bontha, Jagannadha R.; Daniel, Richard C.

The Hanford Waste Treatment and Immobilization Plant (WTP) is currently being designed and constructed to pretreat and vitrify a large portion of the waste in the 177 underground waste storage tanks at the Hanford Site. A number of technical issues related to the design of the pretreatment facility (PTF) of the WTP have been identified. These issues must be resolved prior to the U.S. Department of Energy (DOE) Office of River Protection (ORP) reaching a decision to proceed with engineering, procurement, and construction activities for the PTF. One of the issues is Technical Issue T1 - Hydrogen Gas Release frommore » Vessels (hereafter referred to as T1). The focus of T1 is identifying controls for hydrogen release and completing any testing required to close the technical issue. In advance of selecting specific controls for hydrogen gas safety, a number of preliminary technical studies were initiated to support anticipated future testing and to improve the understanding of hydrogen gas generation, retention, and release within PTF vessels. These activities supported the development of a plan defining an overall strategy and approach for addressing T1 and achieving technical endpoints identified for T1. Preliminary studies also supported the development of a test plan for conducting testing and analysis to support closing T1. Both of these plans were developed in advance of selecting specific controls, and in the course of working on T1 it was decided that the testing and analysis identified in the test plan were not immediately needed. However, planning activities and preliminary studies led to significant technical progress in a number of areas. This report summarizes the progress to date from the preliminary technical studies. The technical results in this report should not be used for WTP design or safety and hazards analyses and technical results are marked with the following statement: “Preliminary Technical Results for Planning – Not to be used for WTP Design or Safety Analyses.”« less

Preclinical testing for aortic endovascular grafts: results of a Food and Drug Administration workshop.

PubMed

Abel, Dorothy B; Beebe, Hugh G; Dedashtian, Mark M; Morton, Michael C; Moynahan, Megan; Smith, Loius J; Weinberg, Steven L

2002-05-01

Since their introduction into clinical trials in the United States, endovascular aortic grafts have shown various types of problems. Although details of design and construction vary between different endovascular grafts and failure modes have had a variety of causes and clinical effects, the inability of preclinical testing to predict these failures remains common to all endovascular grafts. The need to improve preclinical testing in an attempt to reduce clinical device failures resulted in a Food and Drug Administration-sponsored workshop on endovascular graft preclinical testing held in Rockville, Md, from July 31 to August 1, 2001. FORMAT: The workshop was not designed as a consensus conference. Instead, it provided a forum for bringing stakeholders together to define problems and identify areas of agreement and disagreement. The workshop had 34 invited participants who represented device manufacturers, the medical community, the Food and Drug Administration, and testing facilities, and international attendance was more than 120 people. Discussion centered on: 1, defining the physiologic, anatomic, and morphologic characteristics of abdominal aortic aneurysms before and after endovascular graft treatment; 2, identifying the types of failures that have been observed clinically; and 3, determining which characteristics should be considered during preclinical modeling to better predict clinical performance. Attendees agreed to the need to better define and address anatomic characteristics and changes in the aneurysm after endograft treatment to optimize preclinical testing. Much discussion and little agreement occurred on the importance of flow-related forces on graft performance or the need or ability to define and model physiologic compliance during durability testing. The discussion and conclusions are summarized in this paper and are provided in detail at: http://www.fda.gov/cdrh/meetings/073101workshop.html. The workshop raised awareness of significant performance issues and the challenges of modeling the extremely variable and relatively undefined environment of abdominal aortic aneurysms. Through the interactive format of the workshop, participants identified areas of preclinical testing, device design, and aspects of the simulated environment that need further consideration.

Photovoltaic system criteria documents. Volume 3: Environmental issues and evaluation criteria for photovoltaic applications

NASA Technical Reports Server (NTRS)

Koenig, John C.; Billitti, Joseph W.; Tallon, John M.

1979-01-01

The environmental issues and evaluation criteria relating to the suitability of sites proposed for photovoltaic (PV) system deployment are identified. The important issues are defined, briefly discussed and then developed into evaluation criteria. System designers are provided with information on the environmental sensitivity of PV systems in realistic applications, background material which indicates the applicability of the siting issues identified, and evaluation criteria are defined to facilitate the selection of sites that maximize PV system operation.

Development of dual sensor hand-held detector

NASA Astrophysics Data System (ADS)

Sezgin, Mehmet

2010-04-01

In this paper hand-held dual sensor detector development requirements are considered dedicated to buried object detection. Design characteristics of such a system are categorized and listed. Hardware and software structures, ergonomics, user interface, environmental and EMC/EMI tests to be applied and performance test issues are studied. Main properties of the developed system (SEZER) are presented, which contains Metal Detector (MD) and Ground Penetrating Radar (GPR). The realized system has ergonomic structure and can detect both metallic and non-metallic buried objects. Moreover classification of target is possible if it was defined to the signal processing software in learning phase.

Ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries: protocol for a systematic review.

PubMed

Zhong, Adrina; Darren, Benedict; Dimaras, Helen

2017-07-11

There has been little focus in the literature on how to build genetic testing and counseling services in low- and middle-income countries in a responsible, ethical, and culturally appropriate manner. It is unclear to what extent this area is being explored and what form further research should take. The proposed knowledge synthesis aims to fill this gap in knowledge and mine the existing data to determine the breadth of work in this area and identify ethical, social, and cultural issues that have emerged. An integrated knowledge translation approach will be undertaken by engaging knowledge users throughout the review to ensure relevance to their practice. Electronic databases encompassing various disciplines, such as healthcare, social sciences, and public health, will be searched. Studies that address clinical genetic testing and/or counseling and ethical, social, and/or cultural issues of these genetic services, and are performed in low- and middle-income countries as defined by World Bank will be considered for inclusion. Two independent reviewers will be involved in a two-stage literature screening process, data extraction, and quality appraisal. Studies included in the review will be analyzed by thematic analysis. A narrative synthesis guided by the social ecological model will be used to summarize findings. This systematic review will provide a foundation of evidence regarding ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries. Using the social ecological model as a conceptual framework will facilitate the understanding of broader influences of the sociocultural context on an individual's experience with clinical genetic testing and counseling, thereby informing interdisciplinary sectors in future recommendations for practice and policy. PROSPERO CRD42016042894.

Grazing Incidence Optics for X-rays Interferometry

NASA Technical Reports Server (NTRS)

Shipley, Ann; Zissa, David; Cash, Webster; Joy, Marshall

1999-01-01

Grazing incidence mirror parameters and constraints for x-ray interferometry are described. We present interferometer system tolerances and ray trace results used to define mirror surface accuracy requirements. Mirror material, surface figure, roughness, and geometry are evaluated based on analysis results. We also discuss mirror mount design constraints, finite element analysis, environmental issues, and solutions. Challenges associated with quantifying high accuracy mirror surface quality are addressed and test results are compared with theoretical predictions.

Workshop on Production and Uses of Simulated Lunar Materials

NASA Technical Reports Server (NTRS)

1991-01-01

A workshop entitled, Production and Uses of Simulated Lunar Materials, was convened to define the need for simulated lunar materials and examine related issues in support of extended space exploration and development. Lunar samples are a national treasure and cannot be sacrificed in sufficient quantity to test lunar resource utilization process adequately. Hence, the workshop focused on a detailed examination of the variety of potential simulants and the methods for their production.

Terminal Area Productivity Program: Dynamic Spacing Human Factors

NASA Technical Reports Server (NTRS)

Kanki, Barbara G.

1997-01-01

Dynamic spacing human factors deals with the following human factors issues: define controller limits to incorporating dynamic changes in separation standards; identify timing, planning, and coordination strategies; and consider consistency with current practices, policies, and regulations. The AVOSS technologies will make it possible to reduce separation standards in the terminal area under certain meteorological conditions. This paper contains the following sections: Dynamic space human factors overview, Preliminary tests, and current research status & plans.

A Reliability and Validity Study of the Defining Issues Test: The Relationship of Age, Education, Gender and Parental Education with Moral Development

ERIC Educational Resources Information Center

Cesur, Sevim; Topcu, Mustafa Sami

2010-01-01

The aim of the study is twofold: First and main aim was to develop a valid and reliable Turkish version of the DIT which is one of the most important instruments in the psychology and education research; second is to explore the relationships between moral development and age, gender, education, and parental education. The study group consists of…

Development of a moral judgment measure for veterinary education.

PubMed

Verrinder, Joy M; Phillips, Clive J C

2014-01-01

Veterinarians increasingly face animal ethics issues, conflicts, and dilemmas, both in practice and in policy, such as the tension between clients' and animals' interests. Little has been done to measure the capacity of veterinarians to make ethical judgments to prevent and address these issues or to identify the effectiveness of strategies to build this capacity. The objectives of this study were, first, to develop a test to identify the capacity of veterinarians to make ethical decisions in relation to animal ethics issues and, second, to assess students' perceptions of the usefulness of three methods for the development of ethical decision making. The Veterinary Defining Issues Test (VetDIT) was piloted with 88 first-year veterinary students at an Australian university. The veterinary students were at a variety of reasoning stages in their use of the Personal Interest (PI), Maintaining Norms (MN), and Universal Principles (UP) reasoning methods in relation to both human ethics and animal ethics issues and operated at a higher level of reasoning for animal than human ethics. Thirty-eight students assessed three methods for developing ethical decision-making skills and identified these as being helpful in clarifying their positions, clarifying others' positions, increasing awareness of the complexity of making ethical decisions, using ethical frameworks and principles, and improving moral reasoning skills, with two methods identified as most helpful. These methods and the VetDIT have the potential to be used as tools for development and assessment of moral judgment in veterinary education to address animal ethics issues.

Personal Narratives of Genetic Testing: Expectations, Emotions, and Impact on Self and Family.

PubMed

Anderson, Emily E; Wasson, Katherine

2015-01-01

The stories in this volume shed light on the potential of narrative inquiry to fill gaps in knowledge, particularly given the mixed results of quantitative research on patient views of and experiences with genetic and genomic testing. Published studies investigate predictors of testing (particularly risk perceptions and worry); psychological and behavioral responses to testing; and potential impact on the health care system (e.g., when patients bring DTC genetic test results to their primary care provider). Interestingly, these themes did not dominate the narratives published in this issue. Rather, these narratives included consistent themes of expectations and looking for answers; complex emotions; areas of contradiction and conflict; and family impact. More narrative research on patient experiences with genetic testing may fill gaps in knowledge regarding how patients define the benefits of testing, changes in psychological and emotional reactions to test results over time, and the impact of testing on families.

Space Telecommunications Radio System (STRS) Compliance Testing

NASA Technical Reports Server (NTRS)

Handler, Louis M.

2011-01-01

The Space Telecommunications Radio System (STRS) defines an open architecture for software defined radios. This document describes the testing methodology to aid in determining the degree of compliance to the STRS architecture. Non-compliances are reported to the software and hardware developers as well as the NASA project manager so that any non-compliances may be fixed or waivers issued. Since the software developers may be divided into those that provide the operating environment including the operating system and STRS infrastructure (OE) and those that supply the waveform applications, the tests are divided accordingly. The static tests are also divided by the availability of an automated tool that determines whether the source code and configuration files contain the appropriate items. Thus, there are six separate step-by-step test procedures described as well as the corresponding requirements that they test. The six types of STRS compliance tests are: STRS application automated testing, STRS infrastructure automated testing, STRS infrastructure testing by compiling WFCCN with the infrastructure, STRS configuration file testing, STRS application manual code testing, and STRS infrastructure manual code testing. Examples of the input and output of the scripts are shown in the appendices as well as more specific information about what to configure and test in WFCCN for non-compliance. In addition, each STRS requirement is listed and the type of testing briefly described. Attached is also a set of guidelines on what to look for in addition to the requirements to aid in the document review process.

Defining human death: an intersection of bioethics and metaphysics.

PubMed

Manninen, Bertha Alvarez

2009-01-01

For many years now, bioethicists, physicians, and others in the medical field have disagreed concerning how to best define human death. Different theories range from the Harvard Criteria of Brain Death, which defines death as the cessation of all brain activity, to the Cognitive Criteria, which is based on the loss of almost all core mental properties, e.g., memory, self-consciousness, moral agency, and the capacity for reason. A middle ground is the Irreversibility Standard, which defines death as occurring when the capacity for consciousness is forever lost. Given all these different theories, how can we begin to approach solving the issue of how to define death? I propose that a necessary starting point is discussing an even more fundamental question that properly belongs in the philosophical field of metaphysics: we must first address the issue of diachronic identity over time, and the persistence conditions of personal identity. In this paper, I illustrate the interdependent relationship between this metaphysical question and questions concerning the definition of death. I also illustrate how it is necessary to antecedently attend to the metaphysical issue of defining death before addressing certain issues in medical ethics, e.g., whether it is morally permissible to euthanize patients in persistent vegetative states or procure organs from anencephalic infants.

Defining and Responding to Issues of Canada's Coastal Zones.

ERIC Educational Resources Information Center

Diamond, Lawrence

1984-01-01

Defines and discusses critical issues for each of Canada's coastal regions (Pacific, Arctic, Atlantic, and Great Lakes) in environmental, technological, social, and political contexts; reviews recent efforts to obtain and use environmental information; and highlights alternative ways of achieving better stewardship. (Author/DH)

Design of a reliable and operational landslide early warning system at regional scale

NASA Astrophysics Data System (ADS)

Calvello, Michele; Piciullo, Luca; Gariano, Stefano Luigi; Melillo, Massimo; Brunetti, Maria Teresa; Peruccacci, Silvia; Guzzetti, Fausto

2017-04-01

Landslide early warning systems at regional scale are used to warn authorities, civil protection personnel and the population about the occurrence of rainfall-induced landslides over wide areas, typically through the prediction and measurement of meteorological variables. A warning model for these systems must include a regional correlation law and a decision algorithm. A regional correlation law can be defined as a functional relationship between rainfall and landslides; it is typically based on thresholds of rainfall indicators (e.g., cumulated rainfall, rainfall duration) related to different exceedance probabilities of landslide occurrence. A decision algorithm can be defined as a set of assumptions and procedures linking rainfall thresholds to warning levels. The design and the employment of an operational and reliable early warning system for rainfall-induced landslides at regional scale depend on the identification of a reliable correlation law as well as on the definition of a suitable decision algorithm. Herein, a five-step process chain addressing both issues and based on rainfall thresholds is proposed; the procedure is tested in a landslide-prone area of the Campania region in southern Italy. To this purpose, a database of 96 shallow landslides triggered by rainfall in the period 2003-2010 and rainfall data gathered from 58 rain gauges are used. First, a set of rainfall thresholds are defined applying a frequentist method to reconstructed rainfall conditions triggering landslides in the test area. In the second step, several thresholds at different exceedance probabilities are evaluated, and different percentile combinations are selected for the activation of three warning levels. Subsequently, within steps three and four, the issuing of warning levels is based on the comparison, over time and for each combination, between the measured rainfall and the pre-defined warning level thresholds. Finally, the optimal percentile combination to be employed in the regional early warning system is selected evaluating the model performance in terms of success and error indicators by means of the "event, duration matrix, performance" (EDuMaP) method.

Establishing a communications-intensive network to resolve artificial intelligence issues within NASA's Space Station Freedom research centers community

NASA Technical Reports Server (NTRS)

Howard, E. Davis, III

1990-01-01

MITRE Corporation's, A Review of Space Station Freedom Program Capabilities for the Development and Application of Advanced Automation, cites as a critical issue the following situation, extant at the NASA facilities visited in the course of preparing the review: The major issues noted with regard to design and research facilities deal with cooperative problem solving, technology transfer, and communication between these facilities. While the authors were visiting lab and test beds to collect information, personnel at many of these facilities were interested in any information they could collect on activities at other facilities. A formal means of gathering this information could not be identified by these personnel. While communication between some facilities was taking place or was planned, for technology transfer or coordination of schedules (e.g., for SADP demonstrations), poor communication between these facilities could lead to a lack of technical standards, duplication of effort, poorly defined interfaces, scheduling problems, and increased cost. Formal mechanisms by which effective communication and cooperative problem solving can take place, and information can be disseminated, must be defined. A solution is proposed for the communications aspects of the issues addressed above; and offered at the same time a solution which can prove effective in dealing with some of the problems being encountered with expertise being lost via retirement or defection to the private sector. The proffered recommendations are recognizably cost-effective and tap the rising sector of expert knowledge being produced by the American academic community.

Lessons Learned in the First Year Operating Software Defined Radios in Space

NASA Technical Reports Server (NTRS)

Chelmins, David; Mortensen, Dale; Shalkhauser, Mary Jo; Johnson, Sandra K.; Reinhart, Richard

2014-01-01

Operating three unique software defined radios (SDRs) in a space environment aboard the Space Communications and Navigation (SCaN) Testbed for over one year has provided an opportunity to gather knowledge useful for future missions considering using software defined radios. This paper provides recommendations for the development and use of SDRs, and it considers the details of each SDRs approach to software upgrades and operation. After one year, the SCaN Testbed SDRs have operated for over 1000 hours. During this time, the waveforms launched with the SDR were tested on-orbit to assure that they operated in space at the same performance level as on the ground prior to launch to obtain an initial on-orbit performance baseline. A new waveform for each SDR has been developed, implemented, uploaded to the flight system, and tested in the flight environment. Recommendations for SDR-based missions have been gathered from early development through operations. These recommendations will aid future missions to reduce the cost, schedule, and risk of operating SDRs in a space environment. This paper considers the lessons learned as they apply to SDR pre-launch checkout, purchasing space-rated hardware, flexibility in command and telemetry methods, on-orbit diagnostics, use of engineering models to aid future development, and third-party software. Each SDR implements the SCaN Testbed flight computer command and telemetry interface uniquely, allowing comparisons to be drawn. The paper discusses the lessons learned from these three unique implementations, with suggestions on the preferred approach. Also, results are presented showing that it is important to have full system performance knowledge prior to launch to establish better performance baselines in space, requiring additional test applications to be developed pre-launch. Finally, the paper presents the issues encountered with the operation and implementation of new waveforms on each SDR and proposes recommendations to avoid these issues.

Lessons Learned in the First Year Operating Software Defined Radios in Space

NASA Technical Reports Server (NTRS)

Chelmins, David; Mortensen, Dale; Shalkhauser, Mary Jo; Johnson, Sandra K.; Reinhart, Richard

2014-01-01

Operating three unique software defined radios (SDRs) in a space environment aboard the Space Communications and Navigation (SCaN) Testbed for over one year has provided an opportunity to gather knowledge useful for future missions considering using software defined radios. This paper provides recommendations for the development and use of SDRs, and it considers the details of each SDR's approach to software upgrades and operation. After one year, the SCaN Testbed SDRs have operated for over 1000 hours. During this time, the waveforms launched with the SDR were tested on-orbit to assure that they operated in space at the same performance level as on the ground prior to launch to obtain an initial on-orbit performance baseline. A new waveform for each SDR has been developed, implemented, uploaded to the flight system, and tested in the flight environment. Recommendations for SDR-based missions have been gathered from early development through operations. These recommendations will aid future missions to reduce the cost, schedule, and risk of operating SDRs in a space environment. This paper considers the lessons learned as they apply to SDR pre-launch checkout, purchasing space-rated hardware, flexibility in command and telemetry methods, on-orbit diagnostics, use of engineering models to aid future development, and third-party software. Each SDR implements the SCaN Testbed flight computer command and telemetry interface uniquely, allowing comparisons to be drawn. The paper discusses the lessons learned from these three unique implementations, with suggestions on the preferred approach. Also, results are presented showing that it is important to have full system performance knowledge prior to launch to establish better performance baselines in space, requiring additional test applications to be developed pre-launch. Finally, the paper presents the issues encountered with the operation and implementation of new waveforms on each SDR and proposes recommendations to avoid these issues.

Conventional and genetic talent identification in sports: will recent developments trace talent?

PubMed

Breitbach, Sarah; Tug, Suzan; Simon, Perikles

2014-11-01

The purpose of talent identification (TI) is the earliest possible selection of auspicious athletes with the goal of systematically maximizing their potential. The literature proposes excellent reviews on various facets of talent research on different scientific issues such as sports sciences or genetics. However, the approaches of conventional and genetic testing have only been discussed separately by and for the respective groups of interest. In this article, we combine the discoveries of these disciplines into a single review to provide a comprehensive overview and elucidate the prevailing limitations. Fundamental problems in TI reside in the difficulties of defining the construct ‘talent’ or groups of different performance levels that represent the target variable of testing. Conventional and genetic testing reveal a number of methodological and technical limitations, and parallels are summarised in terms of the test designs, the point in time of testing, psychological skills or traits and unknown interactions between different variables. In conclusion, many deficiencies in the current talent research have gained attention. Alternative solutions include the talent development approach, while genetic testing is re-emphasised as a tool for risk stratification in sport participation. Future research needs to clearly define the group of interest and comprehensively implement all methodological improvement suggestions.

Methodology for Flight Relevant Arc-Jet Testing of Flexible Thermal Protection Systems

NASA Technical Reports Server (NTRS)

Mazaheri, Alireza; Bruce, Walter E., III; Mesick, Nathaniel J.; Sutton, Kenneth

2013-01-01

A methodology to correlate flight aeroheating environments to the arc-jet environment is presented. For a desired hot-wall flight heating rate, the methodology provides the arcjet bulk enthalpy for the corresponding cold-wall heating rate. A series of analyses were conducted to examine the effects of the test sample model holder geometry to the overall performance of the test sample. The analyses were compared with arc-jet test samples and challenges and issues are presented. The transient flight environment was calculated for the Hypersonic Inflatable Aerodynamic Decelerator (HIAD) Earth Atmospheric Reentry Test (HEART) vehicle, which is a planned demonstration vehicle using a large inflatable, flexible thermal protection system to reenter the Earth's atmosphere from the International Space Station. A series of correlations were developed to define the relevant arc-jet test environment to properly approximate the HEART flight environment. The computed arcjet environments were compared with the measured arc-jet values to define the uncertainty of the correlated environment. The results show that for a given flight surface heat flux and a fully-catalytic TPS, the flight relevant arc-jet heat flux increases with the arc-jet bulk enthalpy while for a non-catalytic TPS the arc-jet heat flux decreases with the bulk enthalpy.

Testing of CMA-2000 Microwave Landing System (MLS) airborne receiver

NASA Astrophysics Data System (ADS)

Labreche, L.; Murfin, A. J.

1989-09-01

Microwave landing system (MLS) is a precision approach and landing guidance system which provides position information and various air to ground data. Position information is provided on a wide coverage sector and is determined by an azimuth angle measurement, an elevation angle measurement, and a range measurement. MLS performance standards and testing of the MLS airborne receiver is mainly governed by Technical Standard Order TSO-C104 issued by the Federal Aviation Administration. This TSO defines detailed test procedures for use in determining the required performance under standard and stressed conditions. It also imposes disciplines on software development and testing procedures. Testing performed on the CMA-2000 MLS receiver and methods used in its validation are described. A computer automated test system has been developed to test for compliance with RTCA/DO-177 Minimum Operation Performance Standards. Extensive software verification and traceability tests designed to ensure compliance with RTCA/DO-178 are outlined.

17 CFR 270.2a-7 - Money market funds.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Security) issued by a Special Purpose Entity (as defined in this paragraph), substantially all of the...) Conduit security means a security issued by a Municipal Issuer (as defined in this paragraph) involving an..., which arrangement or agreement provides for or secures repayment of the security. Municipal issuer means...

17 CFR 270.2a-7 - Money market funds.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Security) issued by a Special Purpose Entity (as defined in this paragraph), substantially all of the...) Conduit security means a security issued by a Municipal Issuer (as defined in this paragraph) involving an..., which arrangement or agreement provides for or secures repayment of the security. Municipal issuer means...

17 CFR 270.2a-7 - Money market funds.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Security) issued by a Special Purpose Entity (as defined in this paragraph), substantially all of the...) Conduit Security means a security issued by a Municipal Issuer (as defined in this paragraph) involving an..., which arrangement or agreement provides for or secures repayment of the security. Municipal Issuer means...

17 CFR 270.2a-7 - Money market funds.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Security) issued by a Special Purpose Entity (as defined in this paragraph), substantially all of the...) Conduit security means a security issued by a Municipal Issuer (as defined in this paragraph) involving an..., which arrangement or agreement provides for or secures repayment of the security. Municipal issuer means...

In-space propellant logistics. Volume 4: Project planning data

NASA Technical Reports Server (NTRS)

1972-01-01

The prephase A conceptual project planning data as it pertains to the development of the selected logistics module configuration transported into earth orbit by the space shuttle orbiter. The data represents the test, implementation, and supporting research and technology requirements for attaining the propellant transfer operational capability for early 1985. The plan is based on a propellant module designed to support the space-based tug with cryogenic oxygen-hydrogen propellants. A logical sequence of activities that is required to define, design, develop, fabricate, test, launch, and flight test the propellant logistics module is described. Included are the facility and ground support equipment requirements. The schedule of activities are based on the evolution and relationship between the R and T, the development issues, and the resultant test program.

Relationship among science teacher personality characteristics and degree of teacher classroom implementation after in-service workshop

NASA Astrophysics Data System (ADS)

Sechler, Phares Lochiel Coleman

State departments of public instruction require that teachers periodically update their licenses throughout their teaching careers. Various professional development events such as in-service workshops, university offerings, and special innovative programs provide opportunities for novice and experienced teachers to grow professionally. The "Team Science" workshop was designed from models supported by research that described guidelines for successful workshop strategies. In evaluating the workshop, the question was asked "Why did not all teachers implement the ideas from the workshop in their science classrooms?" This study investigates the possible relationship between teacher personality characteristics and implementation of technology innovations. Team Science was an extensive workshop program planned to develop science teachers' expertise in using computer and video technology to teach in physical science, chemistry, and physics classrooms in rural school in North Carolina. Upon evaluating the four-year effort, it was found that the 23 participants implemented the technological strategies at various levels. At the higher end of the range of technology use, some teachers exhibited complete integration of the computers and interfacing devices into both the laboratory work and the classroom inquiry. At the lower end of the range, some teachers used the technology very little. The resulting question emerged from the data collected: Do specific teacher personality characteristics (independent variables) correlate with the degree of implementation (dependent variable) of the innovative ideas and tools used in the teacher's science classroom after the in-service workshop? To determine if there were any significant personality traits, each teacher was given five personality tests. The tests were Hunt's Conceptual Development Test, the Paragraph Completion Test; James Rest's Defining Issues Test; Simmons Personal Survey, an emotional tendency test; the Myers-Briggs Type Indicator; and Riggs and Enochs Self-Efficacy Test. The data were analyzed using descriptive statistics, multiple regression, and factor analysis to see what variables were predictors of implementation. The regression analysis revealed that subtests from Myers-Briggs Type Indicator, Simmons Personal Survey, Hunt's Paragraph Completion Test, and Rest's Defining Issues Test could be used to predict implementation. Factor analysis indicated teachers who implemented the technology were "risk takers" and "flexible planners."

[Cultural and trivial knowledge among Chilean university students].

PubMed

Vargas C, Nelson A; Pinochet T, Dante; Juárez E, Paula

2010-03-01

Culture is defined by the Webster's dictionary as acquaintance with and taste in fine arts, humanities, and broad aspects of science as distinguished from vocational and technical skills. To assess the general cultural knowledge of university students. A test containing 58 questions about art, national and universal literature, national and universal history, mythology science and trivial national issues was designed and applied to 251 medical students in Santiago (149 from first year and 86 from fifth year, Universidad de Chile) and 138 agronomy students in Valdivia (61 from first year and 77 from fifth year, Universidad Austral de Chile). All students answered the test. Medical students from first and fifth year omitted 19 and 15% of questions respectively The figures for first and fifth year agronomy students were 23% each. The percentage of cored answers among first and fifth year medical students was 50 and 59% respectively. The figures for first and fifth year agronomy students were 39 and 44% respectively. The questions with higher rates of cored answers were those about trivial issues. There was a high rate of omissions and wrong answers about general cultural issues among university students particularly in national cultural subjects.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cabrera-Palmer, Belkis

Predicting the performance of radiation detection systems at field sites based on measured performance acquired under controlled conditions at test locations, e.g., the Nevada National Security Site (NNSS), remains an unsolved and standing issue within DNDO’s testing methodology. Detector performance can be defined in terms of the system’s ability to detect and/or identify a given source or set of sources, and depends on the signal generated by the detector for the given measurement configuration (i.e., source strength, distance, time, surrounding materials, etc.) and on the quality of the detection algorithm. Detector performance is usually evaluated in the performance and operationalmore » testing phases, where the measurement configurations are selected to represent radiation source and background configurations of interest to security applications.« less

A Framework for Defining and Assessing Occupational and Training Standards in Developing Countries. Information Series.

ERIC Educational Resources Information Center

Fretwell, David H.; Lewis, Morgan V.; Deij, Arjen

The key issues, alternatives, and implications for developing countries to consider when designing systems to define occupational standards, related training standards, and assessments were analyzed. The analysis focused on the following issues: the rationale for development of standards; clarification of definitions, terminology, and assumptions;…

22 CFR 92.53 - “Commission to take depositions” defined.

Code of Federal Regulations, 2010 CFR

2010-04-01

... SERVICES Depositions and Letters Rogatory § 92.53 “Commission to take depositions” defined. A commission to take depositions is a written authority issued by a court of justice, or by a quasi-judicial body, or a... commission to take depositions is issued only when necessary or convenient, on application and notice. The...

22 CFR 92.53 - “Commission to take depositions” defined.

Code of Federal Regulations, 2011 CFR

2011-04-01

... SERVICES Depositions and Letters Rogatory § 92.53 “Commission to take depositions” defined. A commission to take depositions is a written authority issued by a court of justice, or by a quasi-judicial body, or a... commission to take depositions is issued only when necessary or convenient, on application and notice. The...

1992

EPA Science Inventory

There are two classes of statistical issues: firm issues amenable to problem statement and technical resolution and soft issues that have qualitative dimensions and ideological implications. irm issues are easy: defining and stating the problem is much of the solution. he soft is...

Defining criteria for good environmental journalism and testing their applicability: An environmental news review as a first step to more evidence based environmental science reporting.

PubMed

Rögener, Wiebke; Wormer, Holger

2017-05-01

While the quality of environmental science journalism has been the subject of much debate, a widely accepted benchmark to assess the quality of coverage of environmental topics is missing so far. Therefore, we have developed a set of defined criteria of environmental reporting. This instrument and its applicability are tested in a newly established monitoring project for the assessment of pieces on environmental issues, which refer to scientific sources and therefore can be regarded as a special field of science journalism. The quality is assessed in a kind of journalistic peer review. We describe the systematic development of criteria, which might also be a model procedure for other fields of science reporting. Furthermore, we present results from the monitoring of 50 environmental reports in German media. According to these preliminary data, the lack of context and the deficient elucidation of the evidence pose major problems in environmental reporting.

Direct-to-consumer genetic testing for predicting sports performance and talent identification: Consensus statement

PubMed Central

Webborn, Nick; Williams, Alun; McNamee, Mike; Bouchard, Claude; Pitsiladis, Yannis; Ahmetov, Ildus; Ashley, Euan; Byrne, Nuala; Camporesi, Silvia; Collins, Malcolm; Dijkstra, Paul; Eynon, Nir; Fuku, Noriyuki; Garton, Fleur C; Hoppe, Nils; Holm, Søren; Kaye, Jane; Klissouras, Vassilis; Lucia, Alejandro; Maase, Kamiel; Moran, Colin; North, Kathryn N; Pigozzi, Fabio; Wang, Guan

2015-01-01

The general consensus among sport and exercise genetics researchers is that genetic tests have no role to play in talent identification or the individualised prescription of training to maximise performance. Despite the lack of evidence, recent years have witnessed the rise of an emerging market of direct-to-consumer marketing (DTC) tests that claim to be able to identify children's athletic talents. Targeted consumers include mainly coaches and parents. There is concern among the scientific community that the current level of knowledge is being misrepresented for commercial purposes. There remains a lack of universally accepted guidelines and legislation for DTC testing in relation to all forms of genetic testing and not just for talent identification. There is concern over the lack of clarity of information over which specific genes or variants are being tested and the almost universal lack of appropriate genetic counselling for the interpretation of the genetic data to consumers. Furthermore independent studies have identified issues relating to quality control by DTC laboratories with different results being reported from samples from the same individual. Consequently, in the current state of knowledge, no child or young athlete should be exposed to DTC genetic testing to define or alter training or for talent identification aimed at selecting gifted children or adolescents. Large scale collaborative projects, may help to develop a stronger scientific foundation on these issues in the future. PMID:26582191

Fluid intelligence: A brief history.

PubMed

Kent, Phillip

2017-01-01

The concept of fluid and crystallized intelligence was introduced to the psychological community approximately 75 years ago by Raymond B. Cattell, and it continues to be an area of active research and controversy. The purpose of this paper is to provide a brief overview of the origin of the concept, early efforts to define intelligence and uses of intelligence tests to address pressing social issues, and the ongoing controversies associated with fluid intelligence and the structure of intelligence. The putative neuropsychological underpinnings and neurological substrates of fluid intelligence are discussed.

Time-Reversal Based Range Extension Technique for Ultra-wideband (UWB) Sensors and Applications in Tactical Communications and Networking

DTIC Science & Technology

2008-04-16

Zhen (Edward) Hu Peng (Peter) Zhang Yu Song Amanpreet Singh Saini Corey Cooke April 16, 2006 Department of Electrical and Computer Engineering Center...and RF frequency agility is the most challenging issue for spectrum sensing. The radio under development is an ultra-wideband software -defined radio...PC USB programming cable and accom- panying PC software as well as download test vectors to the waveform memory module, as shown in Figure 3.25,3I

WFPC2 Science Capability Report

NASA Astrophysics Data System (ADS)

Brown, David I.

2001-01-01

In the following pages, a brief outline of the salient science features of Wide Field/Planetary Camera 2 (WFPC2) that impact the proposal writing process and conceptual planning of observations is presented. At the time of writing, WFPC2, while having been better defined than in the past, is far from being at the stage where science and engineering details are well enough known that concrete observational/operational sequences can be plannned with assurance. Conceptual issues are another matter. The thrust of the Science Capability Report at this time is to outline the known performance parameters and capabilities of WFPC2, filling in with specifications when necessary to hold a place for these items as they become known. Also, primary scientific and operational differences between WFPC 1 and 2 are discussed section-by-section, along with issues that remain to be determined and idiosyncrasies when known. Clearly the determination of the latter awaits some form of testing, most likely thermal/vacuum testing. All data in this report should be viewed with a jaundiced eye at this time.

Built-In Data-Flow Integration Testing in Large-Scale Component-Based Systems

NASA Astrophysics Data System (ADS)

Piel, Éric; Gonzalez-Sanchez, Alberto; Gross, Hans-Gerhard

Modern large-scale component-based applications and service ecosystems are built following a number of different component models and architectural styles, such as the data-flow architectural style. In this style, each building block receives data from a previous one in the flow and sends output data to other components. This organisation expresses information flows adequately, and also favours decoupling between the components, leading to easier maintenance and quicker evolution of the system. Integration testing is a major means to ensure the quality of large systems. Their size and complexity, together with the fact that they are developed and maintained by several stake holders, make Built-In Testing (BIT) an attractive approach to manage their integration testing. However, so far no technique has been proposed that combines BIT and data-flow integration testing. We have introduced the notion of a virtual component in order to realize such a combination. It permits to define the behaviour of several components assembled to process a flow of data, using BIT. Test-cases are defined in a way that they are simple to write and flexible to adapt. We present two implementations of our proposed virtual component integration testing technique, and we extend our previous proposal to detect and handle errors in the definition by the user. The evaluation of the virtual component testing approach suggests that more issues can be detected in systems with data-flows than through other integration testing approaches.

Scalability and Validation of Big Data Bioinformatics Software.

PubMed

Yang, Andrian; Troup, Michael; Ho, Joshua W K

2017-01-01

This review examines two important aspects that are central to modern big data bioinformatics analysis - software scalability and validity. We argue that not only are the issues of scalability and validation common to all big data bioinformatics analyses, they can be tackled by conceptually related methodological approaches, namely divide-and-conquer (scalability) and multiple executions (validation). Scalability is defined as the ability for a program to scale based on workload. It has always been an important consideration when developing bioinformatics algorithms and programs. Nonetheless the surge of volume and variety of biological and biomedical data has posed new challenges. We discuss how modern cloud computing and big data programming frameworks such as MapReduce and Spark are being used to effectively implement divide-and-conquer in a distributed computing environment. Validation of software is another important issue in big data bioinformatics that is often ignored. Software validation is the process of determining whether the program under test fulfils the task for which it was designed. Determining the correctness of the computational output of big data bioinformatics software is especially difficult due to the large input space and complex algorithms involved. We discuss how state-of-the-art software testing techniques that are based on the idea of multiple executions, such as metamorphic testing, can be used to implement an effective bioinformatics quality assurance strategy. We hope this review will raise awareness of these critical issues in bioinformatics.

Towards a cognitive resource limitations model of diminished expression in schizotypy.

PubMed

Cohen, Alex S; Morrison, Sean C; Brown, Laura A; Minor, Kyle S

2012-02-01

Diminished expression of speech is a pernicious feature of both schizophrenia and schizotypy--defined as the personality organization reflecting a putative genetic schizophrenia liability. As yet, the mechanism underlying diminished expression is unclear. We tested the hypothesis that diminished expression reflects a cognitive resource issue--that is, as cognitive resources are depleted, expression becomes diminished in individuals with psychometrically defined schizotypy. Acoustic analysis of natural speech was procured during experimentally manipulated baseline and high cognitive-load dual tasks and examined in 38 individuals with psychometrically defined schizotypy and 34 controls. For both groups, expression significantly decreased as a function of increased task demands, although there were no group differences in expression or magnitude of change across baseline to high cognitive-load conditions. Participants with self-reported constricted affect showed significant reductions in expression under high-load versus baseline speaking conditions relative to other schizotypal and control participants. Moreover, psychometrically defined schizotypal participants with poor cognitive performance on the high-load task, suggestive of depleted cognitive resources, also showed expressivity reductions compared with other participants. These findings suggest that diminished expression occurs as a function of limited cognitive resources in psychometrically defined schizotypy. PsycINFO Database Record (c) 2012 APA, all rights reserved.

Designing a biomechanics investigation: choosing the right model.

PubMed

Olson, Steven A; Marsh, J Lawrence; Anderson, Donald D; Latta Pe, Loren L

2012-12-01

Physical testing is commonly performed to answer important biomechanical questions in the treatment of patients with fractures and other orthopaedic conditions. However, a variety of mistakes that are made in performing such investigations can severely limit their impact. The goal of this article is to discuss important aspects of study design to consider when planning for biomechanical investigations so that the studies can provide maximal benefit to the field. The best mechanical investigations begin with a good research question, one that comes out of patient care experience, is clearly defined, and can be stated concisely. The first practical issue to be considered is often choosing the type of physical specimens to be tested to address the research question. A related issue involves determining how many specimens will be needed to answer the posed mechanical question. Cadavers are generally still the closest to the actual clinical situation, but they are limited by interspecimen variability, which often requires a matched pair design that can address only one question. Simulated bone specimens limit variability and can replicate normal and osteoporotic bone. In planning the physical testing, the critical mechanical variables involved in answering the research question must be identified and due consideration given to deciding how best to measure them. Another important issue that arises relates to whether or not single static loadings will suffice in the testing (eg, to study construct stiffness) or whether cyclic dynamic testing is necessary (eg, to study late failure likely attributable to fatigue). To summarize, experimental design should be carefully planned before initiating mechanical testing. Sample size calculations should be performed to ensure adequate power and that clinically relevant differences can be detected. This pregame analysis can save significant time and cost and greatly increase the likelihood that the results will advance knowledge.

Intelligence and Creativity in Problem Solving: The Importance of Test Features in Cognition Research

PubMed Central

Jaarsveld, Saskia; Lachmann, Thomas

2017-01-01

This paper discusses the importance of three features of psychometric tests for cognition research: construct definition, problem space, and knowledge domain. Definition of constructs, e.g., intelligence or creativity, forms the theoretical basis for test construction. Problem space, being well or ill-defined, is determined by the cognitive abilities considered to belong to the constructs, e.g., convergent thinking to intelligence, divergent thinking to creativity. Knowledge domain and the possibilities it offers cognition are reflected in test results. We argue that (a) comparing results of tests with different problem spaces is more informative when cognition operates in both tests on an identical knowledge domain, and (b) intertwining of abilities related to both constructs can only be expected in tests developed to instigate such a process. Test features should guarantee that abilities can contribute to self-generated and goal-directed processes bringing forth solutions that are both new and applicable. We propose and discuss a test example that was developed to address these issues. PMID:28220098

Certification Testing Approach for Propulsion System Design

NASA Technical Reports Server (NTRS)

Rodriguez, Henry; Popp, Chris

2005-01-01

The Certification of Propulsion Systems is costly and complex which involves development and qualification testing. The desire of the certification process is to assure all requirements can be demonstrated to be compliant. The purpose of this paper is to address the technical design concerns of certifying a system for flight. The authors of this paper have experience the lessons learned from supporting the Shuttle Program for Main Propulsion and On Orbit Propulsions Systems. They have collaborated design concerns for certifying propulsion systems. Presented are Pressurization, Tankage, Feed System and Combustion Instability concerns. Propulsion System Engineers are challenged with the dilemma for testing new systems to specific levels to reduce risk yet maintain budgetary targets. A methodical approach is presented to define the types of test suitable to address the technical issues for qualifying systems for retiring the risk levels.

Nonconformity defines the self: the role of minority opinion status in self-concept clarity.

PubMed

Morrison, Kimberly Rios; Wheeler, S Christian

2010-03-01

Drawing on distinctiveness and social identity theories, the present studies tested whether minority opinion holders would have a more clearly defined sense of self than majority opinion holders. In Study 1, participants who were induced to believe that they held a minority opinion on a controversial issue had higher subsequent self-concept clarity scores than did those who were induced to believe that they held a majority opinion, controlling for self-esteem. Furthermore, the relationship between minority opinion status and self-concept clarity was strongest among participants whose opinions were highly expressive of their values (Studies 2 and 3), as well as among participants who identified strongly with the group in which they were a minority (Study 3). Theoretical and practical implications of these results are discussed.

Asilomar moments: formative framings in recombinant DNA and solar climate engineering research.

PubMed

Schäfer, Stefan; Low, Sean

2014-12-28

We examine the claim that in governance for solar climate engineering research, and especially field tests, there is no need for external governance beyond existing mechanisms such as peer review and environmental impact assessments that aim to assess technically defined risks to the physical environment. By drawing on the historical debate on recombinant DNA research, we show that defining risks is not a technical question but a complex process of narrative formation. Governance emerges from within, and as a response to, narratives of what is at stake in a debate. In applying this finding to the case of climate engineering, we find that the emerging narrative differs starkly from the narrative that gave meaning to rDNA technology during its formative period, with important implications for governance. While the narrative of rDNA technology was closed down to narrowly focus on technical risks, that of climate engineering continues to open up and includes social, political and ethical issues. This suggests that, in order to be legitimate, governance must take into account this broad perception of what constitutes the relevant issues and risks of climate engineering, requiring governance that goes beyond existing mechanisms that focus on technical risks. Even small-scale field tests with negligible impacts on the physical environment warrant additional governance as they raise broader concerns that go beyond the immediate impacts of individual experiments. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Genetic purgatory and the cardiac channelopathies: Exposing the variants of uncertain/unknown significance issue.

PubMed

Ackerman, Michael J

2015-11-01

Merriam-Webster's online dictionary defines purgatory as "an intermediate state after death for expiatory purification" or more specifically as "a place or state of punishment wherein according to Roman Catholic doctrine the souls of those who die in God׳s grace may make satisfaction for past sins and so become fit for heaven." Alternatively, it is defined as "a place or state of temporary suffering or misery." Either way, purgatory is a place where you are stuck, and you don't want to be stuck there. It is in this context that the term genetic purgatory is introduced. Genetic purgatory is a place where the genetic test-ordering physician and patients and their families are stuck when a variant of uncertain/unknown significance (VUS) has been elucidated. It is in this dark place where suffering and misery are occurring because of unenlightened handling of a VUS, which includes using the VUS for predictive genetic testing and making radical treatment recommendations based on the presence or absence of a so-called maybe mutation. Before one can escape from this miserable place, one must first recognize that one is stuck there. Hence, the purpose of this review article is to fully expose the VUS issue as it relates to the cardiac channelopathies and make the cardiologists/geneticists/genetic counselors who order such genetic tests believers in genetic purgatory. Only then can one meaningfully attempt to get out of that place and seek to promote a VUS to disease-causative mutation status or demote it to an utterly innocuous and irrelevant variant. Copyright © 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Threshold detection of boar taint chemicals using parasitic wasps.

PubMed

Olson, Dawn; Wäckers, Felix; Haugen, John-Erik

2012-10-01

Surgical castration has been long used to prevent consumers from experiencing taint in meat from male pigs, which is a large problem in the pig husbandry industry. Due to obvious animal welfare issues, the EU now wants an alternative for castration, suggesting an urgent need for novel methods of boar taint detection. As boar taint is only a problem when taint chemicals exceed a well-defined threshold, detection methods should be concentration-specific. The wasp, Microplitis croceipes' ability to learn and respond to particular concentrations of the boar taint compounds, skatole, androstenone, and indole was tested. Also tested was the wasps' ability to discriminate between known concentrations of indole, skatole, and androstenone in real boar fat samples at room temperature. Wasps were trained using associative learning by providing food-deprived wasps with sucrose-water in the presence of specific odor concentrations. Trained wasps' responses were tested to a range of concentrations of 3 compounds. Wasps showed unidirectional generalization of learned concentration responses, whereby the direction of concentration generalization was shown to be chemical-dependent. Through both positive (sucrose) and negative feeding experiences (water only) with varying compound concentrations, the wasps can also be conditioned to respond to concentrations exceeding a defined threshold, and they were successful in reporting low, medium, and high concentrations of indole, skatole, and androstenone in boar fat at room temperature. The need for threshold detection rather than simple detection of absence/presence applies to many food quality issues, including the detection of spoilage or pest damage in crops or stored foods. An inexpensive and reliable means of detecting boar tainted pork at slaughter to avoid tainted meat on the market and dissatisfied consumers. Journal of Food Science © 2012 Institute of Food Technologists® No claim to original US government works.

Fiber Optic Cable Assemblies for Space Flight 2: Thermal and Radiation Effects

NASA Technical Reports Server (NTRS)

Ott, Melanie N.

1998-01-01

Goddard Space Flight Center is conducting a search for space flight worthy fiber optic cable assemblies that will benefit all projects at all of the NASA centers. This paper is number two in a series of papers being issued as a result of this task to define and qualify space grade fiber optic cable assemblies. Though to qualify and use a fiber optic cable in space requires treatment of the cable assembly as a system, it is very important to understand the design and behavior of its parts. This paper addresses that need, providing information on cable components shrinkage testing and radiation testing results from recent experiments at Goddard Space Flight Center.

46 CFR 8.320 - Classification society authorization to issue international certificates.

Code of Federal Regulations, 2011 CFR

2011-10-01

... classification society authorized to issue international convention certificates. This agreement will define the... 46 Shipping 1 2011-10-01 2011-10-01 false Classification society authorization to issue... Classification society authorization to issue international certificates. (a) The Commandant may authorize a...

Observational methods to assess the effectiveness of screening colonoscopy in reducing right colon cancer mortality risk: SCOLAR.

PubMed

Goodman, Michael; Fletcher, Robert H; Doria-Rose, V Paul; Jensen, Christopher D; Zebrowski, Alexis M; Becerra, Tracy A; Quinn, Virginia P; Zauber, Ann G; Corley, Douglas A; Doubeni, Chyke A

2015-11-01

Screening colonoscopy's effectiveness in reducing risk of death from right colon cancers remains unclear. Methodological challenges of existing observational studies addressing this issue motivated the design of 'Effectiveness of Screening for Colorectal Cancer in Average-Risk Adults (SCOLAR)'. SCOLAR is a nested case-control study based on two large integrated health systems. This affords access to a large, well-defined historical cohort linked to integrated data on cancer outcomes, patient eligibility, test indications and important confounders. We found electronic data adequate for excluding ineligible patients (except family history), but not the detailed information needed for test indication assignment. The lessons of SCOLAR's design and implementation may be useful for future studies seeking to evaluate the effectiveness of screening tests in community settings.

Stock Issues in Aristotle's Rhetoric

ERIC Educational Resources Information Center

Harpine, Bill

1977-01-01

Defines "stock issue" by the manner in which they function in Aristotle's theory, reviews examples of modern theories of stock issues, examines previous investigations of the "Rhetoric," and analyzes Aristotle's approach to this aspect of argumentation. (MH)

The golden goose in the crosshairs: the transition to defined contribution pension plans in the public sector: unintended consequences.

PubMed

Johnson, Brian R

2013-01-01

State, county, and local governments are currently facing a myriad of economic issues, based on shrinking tax revenues combined with increased expenditures. Of these, the costs related to defined benefit pension plans are one of the most serious issues facing many public employers. Through a comprehensive review of the existing literature, this article examines how the shift from the defined benefit (DB) to defined contribution (DC) pension plan has the potential to enhance levels of labor unrest due to changes in union militancy, bargaining skills deficits, intra-organizational conflict, and issues related to economic trade-offs. Besides the capacity for immediate and deleterious ramifications in the collective bargaining process, the transition to the DC pension also presents some potentially negative consequences related to human resource management, including changes in the psychological contract, recruitment strategies, employee turnover, and changes in retirement patterns. Recommendations to improve labor relations and human resource management practices in the DC pension environment are also explored.

Joint Test Protocol for Validation of Alternative Low-Emission Surface Preparation/Depainting Technologies for Structural Steel

NASA Technical Reports Server (NTRS)

Lewis, Pattie

2005-01-01

Headquarters National Aeronautics and Space Administration (NASA) chartered the Acquisition Pollution Prevention (AP2) Office to coordinate agency activities affecting pollution prevention issues identified during system and component acquisition and sustainment processes. The primary objectives of the AP2 Office are to: (1) Reduce or eliminate the use of hazardous materials (HazMats) or hazardous processes at manufacturing, remanufacturing, and sustainment locations. (2) A void duplication of effort in actions required to reduce or eliminate HazMats through joint center cooperation and technology sharing. This project will identify, evaluate and approve alternative surface preparation technologies for use at NASA and Air Force Space Command (AFSPC) installations. Materials and processes will be evaluated with the goal of selecting those processes that will improve corrosion protection at critical systems, facilitate easier maintenance activity, extend maintenance cycles, eliminate flight hardware contamination and reduce the amount of hazardous waste generated. This Joint Test Protocol (JTP) contains the critical requirements and tests necessary to qualify alternative Low-Emission Surface Preparation/Depainting Technologies for Structural Steel Applications. These tests were derived from engineering, performance, and operational impact (supportability) requirements defined by a consensus of NASA and Air Force Space Command (AFSPC) participants. The Field Test Plan (FTP), entitled Joint Test Protocol for Validation of Alternative Low Emission Surface Preparation/Depainting Technologies for Structural Steel, prepared by ITB, defines the field evaluation and testing requirements for validating alternative surface preparation/depainting technologies and supplements the JTP.

Investigating Sustainability Impacts of Bioenergy Usage Within the Eisenwurzen Region in Austria

NASA Astrophysics Data System (ADS)

Putzhuber, F.; Hasenauer, H.

2009-04-01

Within the past few years sustainability and bioenergy usage become a key term in emphasizing the relationship between economic progress and the protection of the environment. One key difficulty is the definition of criteria and indicators for assessing sustainability issues and their change over time. This work introduces methods to create linear parametric models of the sustainable impact issues relevant in the establishment of new bio-energetic heating systems. Our application example is the Eisenwurzen region in Austria. The total area covers 5743 km km² and includes 99 municipalities. A total of 11 impact issues covering the economic, social and environmental areas are proposed for developing the linear parametric models. The indicator selection for deriving the impact issues is based on public official data from 68 indicators, as well as stakeholder interviews and the impact assessment framework. In total we obtained 415 variables from the 99 municipalities to create the 68 indicators for the Local Administration Unit 2 (LAU2) over the last (if available) 25 years. The 68 indicators are on a relative scale to address the size differences of the municipalities. The idea of the analysis is to create linear models which derive 11 defined impact issues related to the establishment of new bio-energetic heating systems. Each analysis follows a strict statistical procedure based on (i) independent indicator selection, (ii) remove indicators with higher VIF value grater then 6, (iii) remove indicators with α higher than 0,05, (iv) possible linear transformation, (v) remove the non-significant indicators (p-value >0,05), (vi) model valuation, (vii) remove the out-lines plots and (viii) test of the normality distribution of the residual with a Kolmogorov- Smirnov test. The results suggest that for the 11 sustainable impact issues 21 of the 68 indicators are significant drives. The models revealed that it is possible to create tools for assessing impact issues in a municipality level. In this case impact issues related to bio-energy usages on a rural mountain region.

[Design of a communicative model from a social perspective oriented toward physical activity].

PubMed

Prieto-Rodríguez, Adriana; Moreno-Angarita, Marisol; Cardozo-Vásquez, Yency S

2006-12-01

A communication model was designed and put into practice, in the form of a Network throughout three regions in Colombia; Bogotá, Antioquia and Quindío. Based on a macro-intentional model, this network was aimed at strengthening understanding around the subject of physical activity among those people affected by the issue, from a multidimensional perspective. The test population was defined and working groups were formed around three strategies: social production, transmission and democratization, during a three-month period. RESULTS Messages were developed based around the ideas of the community producers themselves; the initial concepts were widened to include the body, self care, physical activity and health. Communication models related to health, aimed at developing personal skills including the ability to communicate and build shared experience, can be assimilated and incorporated into broadcasts on health issues. This model serves as a communication strategy which strengthens the building of shared broadcasts on health issues. This kind of focus requires the development of local activity and capacity-building within the community.

The Organizational Decision Making Climate of Issues Management Programs: A Case Study.

ERIC Educational Resources Information Center

Wills, Sandra

A study examined the decision making climate of organizations that are using issues management and what type of model of issues management is followed--theorists have been attempting to define issues management since it began appearing 20 year ago. Subjects, 112 males and 30 females who were professionals working in the area of issues management…

Counseling Psychology Research on Sexual (Orientation) Minority Issues: Conceptual and Methodological Challenges and Opportunities

ERIC Educational Resources Information Center

Moradi, Bonnie; Mohr, Jonathan J.; Worthington, Roger L.; Fassinger, Ruth E.

2009-01-01

This lead article of the special issue discusses conceptual and methodological considerations in studying sexual minority issues, particularly in research conducted by counseling psychologists (including the work represented in this special issue). First, the overarching challenge of conceptualizing and defining sexual minority populations is…

A Case Study of 4 & 5 Cost Effectiveness

NASA Technical Reports Server (NTRS)

Neal, Ralph D.; McCaugherty, Dan; Joshi, Tulasi; Callahan, John

1997-01-01

This paper looks at the Independent Verification and Validation (IV&V) of NASA's Space Shuttle Day of Launch I-Load Update (DoLILU) project. IV&V is defined. The system's development life cycle is explained. Data collection and analysis are described. DoLILU Issue Tracking Reports (DITRs) authored by IV&V personnel are analyzed to determine the effectiveness of IV&V in finding errors before the code, testing, and integration phase of the software development life cycle. The study's findings are reported along with the limitations of the study and planned future research.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rice, John A.

A new, all ceramic magnet insulation system has been developed that can withstand the high radiation doses without significant damage. The insulation can be applied directly onto a Nb3Sn or copper cable as a ceramic based prepreg system using the same equipment and procedures used for the traditional epoxy systems. Excessive porosity was eliminated and compressions strength increased. Thermal expansion nearly matches the expansion of niobium tin conductor wire. A radiation test program has been defined and magnet fabrication issues have been identified. This report covers the results of the Phase I research program.

Comparative Issues and Methods in Organizational Diagnosis. Report II. The Decision Tree Approach.

DTIC Science & Technology

organizational diagnosis . The advantages and disadvantages of the decision-tree approach generally, and in this study specifically, are examined. A pre-test, using a civilian sample of 174 work groups with Survey of Organizations data, was conducted to assess various decision-tree classification criteria, in terms of their similarity to the distance function used by Bowers and Hausser (1977). The results suggested the use of a large developmental sample, which should result in more distinctly defined boundary lines between classification profiles. Also, the decision matrix

Topic Modeling of NASA Space System Problem Reports: Research in Practice

NASA Technical Reports Server (NTRS)

Layman, Lucas; Nikora, Allen P.; Meek, Joshua; Menzies, Tim

2016-01-01

Problem reports at NASA are similar to bug reports: they capture defects found during test, post-launch operational anomalies, and document the investigation and corrective action of the issue. These artifacts are a rich source of lessons learned for NASA, but are expensive to analyze since problem reports are comprised primarily of natural language text. We apply topic modeling to a corpus of NASA problem reports to extract trends in testing and operational failures. We collected 16,669 problem reports from six NASA space flight missions and applied Latent Dirichlet Allocation topic modeling to the document corpus. We analyze the most popular topics within and across missions, and how popular topics changed over the lifetime of a mission. We find that hardware material and flight software issues are common during the integration and testing phase, while ground station software and equipment issues are more common during the operations phase. We identify a number of challenges in topic modeling for trend analysis: 1) that the process of selecting the topic modeling parameters lacks definitive guidance, 2) defining semantically-meaningful topic labels requires nontrivial effort and domain expertise, 3) topic models derived from the combined corpus of the six missions were biased toward the larger missions, and 4) topics must be semantically distinct as well as cohesive to be useful. Nonetheless,topic modeling can identify problem themes within missions and across mission lifetimes, providing useful feedback to engineers and project managers.

Electronic vending machines for dispensing rapid HIV self-testing kits: a case study.

PubMed

Young, Sean D; Klausner, Jeffrey; Fynn, Risa; Bolan, Robert

2014-02-01

This short report evaluates the feasibility of using electronic vending machines for dispensing oral, fluid, rapid HIV self-testing kits in Los Angeles County. Feasibility criteria that needed to be addressed were defined as: (1) ability to find a manufacturer who would allow dispensing of HIV testing kits and could fit them to the dimensions of a vending machine, (2) ability to identify and address potential initial obstacles, trade-offs in choosing a machine location, and (3) ability to gain community approval for implementing this approach in a community setting. To address these issues, we contracted a vending machine company who could supply a customized, Internet-enabled machine that could dispense HIV kits and partnered with a local health center available to host the machine onsite and provide counseling to participants, if needed. Vending machines appear to be feasible technologies that can be used to distribute HIV testing kits.

Modelling accelerated degradation data using Wiener diffusion with a time scale transformation.

PubMed

Whitmore, G A; Schenkelberg, F

1997-01-01

Engineering degradation tests allow industry to assess the potential life span of long-life products that do not fail readily under accelerated conditions in life tests. A general statistical model is presented here for performance degradation of an item of equipment. The degradation process in the model is taken to be a Wiener diffusion process with a time scale transformation. The model incorporates Arrhenius extrapolation for high stress testing. The lifetime of an item is defined as the time until performance deteriorates to a specified failure threshold. The model can be used to predict the lifetime of an item or the extent of degradation of an item at a specified future time. Inference methods for the model parameters, based on accelerated degradation test data, are presented. The model and inference methods are illustrated with a case application involving self-regulating heating cables. The paper also discusses a number of practical issues encountered in applications.

Electronic vending machines for dispensing rapid HIV self-testing kits: A case study

PubMed Central

Young, Sean D.; Klausner, Jeffrey; Fynn, Risa; Bolan, Robert

2014-01-01

This short report evaluates the feasibility of using electronic vending machines for dispensing oral, fluid, rapid HIV-self testing kits in Los Angeles County. Feasibility criteria that needed to be addressed were defined as: 1) ability to find a manufacturer who would allow dispensing of HIV testing kits and could fit them to the dimensions of a vending machine, 2) ability to identify and address potential initial obstacles, trade-offs in choosing a machine location, and 3) ability to gain community approval for implementing this approach in a community setting. To address these issues, we contracted a vending machine company who could supply a customized, Internet-enabled machine that could dispense HIV kits and partnered with a local health center available to host the machine onsite and provide counseling to participants, if needed. Vending machines appear to be feasible technologies that can be used to distribute HIV testing kits. PMID:23777528

Periodontal Research: Basics and beyond – Part II (Ethical issues, sampling, outcome measures and bias)

PubMed Central

Avula, Haritha

2013-01-01

A good research beginning refers to formulating a well-defined research question, developing a hypothesis and choosing an appropriate study design. The first part of the review series has discussed these issues in depth and this paper intends to throw light on other issues pertaining to the implementation of research. These include the various ethical norms and standards in human experimentation, the eligibility criteria for the participants, sampling methods and sample size calculation, various outcome measures that need to be defined and the biases that can be introduced in research. PMID:24174747

Nuclear safety for the space exploration initiative

NASA Technical Reports Server (NTRS)

Dix, Terry E.

1991-01-01

The results of a study to identify potential hazards arising from nuclear reactor power systems for use on the lunar and Martian surfaces, related safety issues, and resolutions of such issues by system design changes, operating procedures, and other means are presented. All safety aspects of nuclear reactor power systems from prelaunch ground handling to eventual disposal were examined consistent with the level of detail for SP-100 reactor design at the 1988 System Design Review and for launch vehicle and space transport vehicle designs and mission descriptions as defined in the 90-day Space Exploration Initiative (SEI) study. Information from previous aerospace nuclear safety studies was used where appropriate. Safety requirements for the SP-100 space nuclear reactor system were compiled. Mission profiles were defined with emphasis on activities after low earth orbit insertion. Accident scenarios were then qualitatively defined for each mission phase. Safety issues were identified for all mission phases with the aid of simplified event trees. Safety issue resolution approaches of the SP-100 program were compiled. Resolution approaches for those safety issues not covered by the SP-100 program were identified. Additionally, the resolution approaches of the SP-100 program were examined in light of the moon and Mars missions.

Computer-aided resource planning and scheduling for radiological services

NASA Astrophysics Data System (ADS)

Garcia, Hong-Mei C.; Yun, David Y.; Ge, Yiqun; Khan, Javed I.

1996-05-01

There exists tremendous opportunity in hospital-wide resource optimization based on system integration. This paper defines the resource planning and scheduling requirements integral to PACS, RIS and HIS integration. An multi-site case study is conducted to define the requirements. A well-tested planning and scheduling methodology, called Constrained Resource Planning model, has been applied to the chosen problem of radiological service optimization. This investigation focuses on resource optimization issues for minimizing the turnaround time to increase clinical efficiency and customer satisfaction, particularly in cases where the scheduling of multiple exams are required for a patient. How best to combine the information system efficiency and human intelligence in improving radiological services is described. Finally, an architecture for interfacing a computer-aided resource planning and scheduling tool with the existing PACS, HIS and RIS implementation is presented.

Analysis of remote operating systems for space-based servicing operations, volume 1

NASA Technical Reports Server (NTRS)

1985-01-01

A two phase study was conducted to analyze and develop the requirements for remote operating systems as applied to space based operations for the servicing, maintenance, and repair of satellites. Phase one consisted of the development of servicing requirements to establish design criteria for remote operating systems. Phase two defined preferred system concepts and development plans which met the requirements established in phase one. The specific tasks in phase two were to: (1) identify desirable operational and conceptual approaches for selected mission scenarios; (2) examine the potential impact of remote operating systems incorporated into the design of the space station; (3) address remote operating systems design issues, such as mobility, which are effected by the space station configuration; and (4) define the programmatic approaches for technology development, testing, simulation, and flight demonstration.

A Study of the Utilization of Advanced Composites in Fuselage Structures of Commercial Aircraft

NASA Technical Reports Server (NTRS)

Watts, D. J.; Sumida, P. T.; Bunin, B. L.; Janicki, G. S.; Walker, J. V.; Fox, B. R.

1985-01-01

A study was conducted to define the technology and data needed to support the introduction of advanced composites in the future production of fuselage structure in large transport aircraft. Fuselage structures of six candidate airplanes were evaluated for the baseline component. The MD-100 was selected on the basis of its representation of 1990s fuselage structure, an available data base, its impact on the schedule and cost of the development program, and its availability and suitability for flight service evaluation. Acceptance criteria were defined, technology issues were identified, and a composite fuselage technology development plan, including full-scale tests, was identified. The plan was based on composite materials to be available in the mid to late 1980s. Program resources required to develop composite fuselage technology are estimated at a rough order of magnitude to be 877 man-years exclusive of the bird strike and impact dynamic test components. A conceptual composite fuselage was designed, retaining the basic MD-100 structural arrangement for doors, windows, wing, wheel wells, cockpit enclosure, major bulkheads, etc., resulting in a 32 percent weight savings.

Magnetotelluric Data, Central Yucca Flat, Nevada Test Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.M. Williams; B.D. Rodriguez, and T.H. Asch

2005-11-23

Nuclear weapons are integral to the defense of the United States. The U.S. Department of Energy, as the steward of these devices, must continue to gauge the efficacy of the individual weapons. This could be accomplished by occasional testing at the Nevada Test Site (NTS) in Nevada, northwest of Las Vegas. Yucca Flat Basin is one of the testing areas at the NTS. One issue of concern is the nature of the somewhat poorly constrained pre-Tertiary geology and its effects on ground-water flow in the area subsequent to a nuclear test. Ground-water modelers would like to know more about themore » hydrostratigraphy and geologic structure to support a hydrostratigraphic framework model that is under development for the Yucca Flat Corrective Action Unit (CAU). During 2003, the U.S. Geological Survey (USGS) collected and processed Magnetotelluric (MT) and Audio-magnetotelluric (AMT) data at the Nevada Test Site in and near Yucca Flat to help characterize this pre-Tertiary geology. That work will help to define the character, thickness, and lateral extent of pre-Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU) in the Yucca Flat area. Interpretation will include a three-dimensional (3-D) character analysis and two-dimensional (2-D) resistivity model. The purpose of this report is to release the MT sounding data for Central Yucca Flat, Profile 1, as shown in figure 1. No interpretation of the data is included here.« less

Magnetotelluric Data, North Central Yucca Flat, Nevada Test Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.M. Williams; B.D. Rodriguez, and T.H. Asch

2005-11-23

Nuclear weapons are integral to the defense of the United States. The U.S. Department of Energy, as the steward of these devices, must continue to gauge the efficacy of the individual weapons. This could be accomplished by occasional testing at the Nevada Test Site (NTS) in Nevada, northwest of Las Vegas. Yucca Flat Basin is one of the testing areas at the NTS. One issue of concern is the nature of the somewhat poorly constrained pre-Tertiary geology and its effects on ground-water flow in the area subsequent to a nuclear test. Ground-water modelers would like to know more about themore » hydrostratigraphy and geologic structure to support a hydrostratigraphic framework model that is under development for the Yucca Flat Corrective Action Unit (CAU). During 2003, the U.S. Geological Survey (USGS) collected and processed Magnetotelluric (MT) and Audio-magnetotelluric (AMT) data at the Nevada Test Site in and near Yucca Flat to help characterize this pre-Tertiary geology. That work will help to define the character, thickness, and lateral extent of pre-Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU) in the Yucca Flat area. Interpretation will include a three-dimensional (3-D) character analysis and two-dimensional (2-D) resistivity model. The purpose of this report is to release the MT sounding data for north central Yucca Flat, Profile 7, as shown in Figure 1. No interpretation of the data is included here.« less

Magnetotelluric Data, Northern Frenchman Flat, Nevada Test Site Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.M. Williams; B.D. Rodriguez, and T. H. Asch

2005-11-23

Nuclear weapons are integral to the defense of the United States. The U.S. Department of Energy, as the steward of these devices, must continue to gauge the efficacy of the individual weapons. This could be accomplished by occasional testing at the Nevada Test Site (NTS) in Nevada, northwest of Las Vegas. Yucca Flat Basin is one of the testing areas at the NTS. One issue of concern is the nature of the somewhat poorly constrained pre-Tertiary geology and its effects on ground-water flow in the area subsequent to a nuclear test. Ground-water modelers would like to know more about themore » hydrostratigraphy and geologic structure to support a hydrostratigraphic framework model that is under development for the Yucca Flat Corrective Action Unit (CAU). During 2003, the U.S. Geological Survey (USGS) collected and processed Magnetotelluric (MT) and Audio-magnetotelluric (AMT) data at the Nevada Test Site in and near Yucca Flat to help characterize this pre-Tertiary geology. That work will help to define the character, thickness, and lateral extent of pre-Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU) in the Yucca Flat area. Interpretation will include a three-dimensional (3-D) character analysis and two-dimensional (2-D) resistivity model. The purpose of this report is to release the MT sounding data for Frenchman Flat Profile 3, as shown in Figure 1. No interpretation of the data is included here.« less

Magnetotelluric Data, Across Quartzite Ridge, Nevada Test Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.M. Williams; B.D. Rodriguez, and T.H. Asch

2005-11-23

Nuclear weapons are integral to the defense of the United States. The U.S. Department of Energy, as the steward of these devices, must continue to gauge the efficacy of the individual weapons. This could be accomplished by occasional testing at the Nevada Test Site (NTS) in Nevada, northwest of Las Vegas. Yucca Flat Basin is one of the testing areas at the NTS. One issue of concern is the nature of the somewhat poorly constrained pre-Tertiary geology and its effects on ground-water flow in the area subsequent to a nuclear test. Ground-water modelers would like to know more about themore » hydrostratigraphy and geologic structure to support a hydrostratigraphic framework model that is under development for the Yucca Flat Corrective Action Unit (CAU). During 2003, the U.S. Geological Survey (USGS) collected and processed Magnetotelluric (MT) and Audio-magnetotelluric (AMT) data at the Nevada Test Site in and near Yucca Flat to help characterize this pre-Tertiary geology. That work will help to define the character, thickness, and lateral extent of pre-Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU) in the Yucca Flat area. Interpretation will include a three-dimensional (3-D) character analysis and two-dimensional (2-D) resistivity model. The purpose of this report is to release the MT soundings across Quartzite Ridge, Profiles 5, 6a, and 6b, as shown in Figure 1. No interpretation of the data is included here.« less

Magnetotelluric Data, Southern Yucca Flat, Nevada Test Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.M. Williams; B.D. Rodriguez, and T.H. Asch

2005-11-23

Nuclear weapons are integral to the defense of the United States. The U.S. Department of Energy, as the steward of these devices, must continue to gauge the efficacy of the individual weapons. This could be accomplished by occasional testing at the Nevada Test Site (NTS) in Nevada, northwest of Las Vegas. Yucca Flat Basin is one of the testing areas at the NTS. One issue of concern is the nature of the somewhat poorly constrained pre-Tertiary geology and its effects on ground-water flow in the area subsequent to a nuclear test. Ground-water modelers would like to know more about themore » hydrostratigraphy and geologic structure to support a hydrostratigraphic framework model that is under development for the Yucca Flat Corrective Action Unit (CAU). During 2003, the U.S. Geological Survey (USGS) collected and processed Magnetotelluric (MT) and Audio-magnetotelluric (AMT) data at the Nevada Test Site in and near Yucca Flat to help characterize this pre-Tertiary geology. That work will help to define the character, thickness, and lateral extent of pre-Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU) in the Yucca Flat area. Interpretation will include a three-dimensional (3-D) character analysis and two-dimensional (2-D) resistivity model. The purpose of this report is to release the MT sounding data for Southern Yucca Flat, Profile 4, as shown in Figure 1. No interpretation of the data is included here.« less

Magnetotelluric Data, Northern Yucca Flat, Nevada Test Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.M. Williams; B.D. Rodriguez, and T.H. Asch

2005-11-23

Nuclear weapons are integral to the defense of the United States. The U.S. Department of Energy, as the steward of these devices, must continue to gauge the efficacy of the individual weapons. This could be accomplished by occasional testing at the Nevada Test Site (NTS) in Nevada, northwest of Las Vegas. Yucca Flat Basin is one of the testing areas at the NTS. One issue of concern is the nature of the somewhat poorly constrained pre-Tertiary geology and its effects on ground-water flow in the area subsequent to a nuclear test. Ground-water modelers would like to know more about themore » hydrostratigraphy and geologic structure to support a hydrostratigraphic framework model that is under development for the Yucca Flat Corrective Action Unit (CAU). During 2003, the U.S. Geological Survey (USGS) collected and processed Magnetotelluric (MT) and Audio-magnetotelluric (AMT) data at the Nevada Test Site in and near Yucca Flat to help characterize this pre-Tertiary geology. That work will help to define the character, thickness, and lateral extent of pre-Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU) in the Yucca Flat area. Interpretation will include a three-dimensional (3-D) character analysis and two-dimensional (2-D) resistivity model. The purpose of this report is to release the MT sounding data for Profile 2, (fig. 1), located in the northern Yucca Flat area. No interpretation of the data is included here.« less

Rocketdyne LOX bearing tester program

NASA Technical Reports Server (NTRS)

Keba, J. E.; Beatty, R. F.

1988-01-01

The cause, or causes, for the Space Shuttle Main Engine ball wear were unknown, however, several mechanisms were suspected. Two testers were designed and built for operation in liquid oxygen to empirically gain insight into the problems and iterate solutions in a timely and cost efficient manner independent of engine testing. Schedules and test plans were developed that defined a test matrix consisting of parametric variations of loading, cooling or vapor margin, cage lubrication, material, and geometry studies. Initial test results indicated that the low pressure pump thrust bearing surface distress is a function of high axial load. Initial high pressure turbopump bearing tests produced the wear phenomenon observed in the turbopump and identified an inadequate vapor margin problem and a coolant flowrate sensitivity issue. These tests provided calibration data of analytical model predictions to give high confidence in the positive impact of future turbopump design modification for flight. Various modifications will be evaluated in these testers, since similar turbopump conditions can be produced and the benefit of the modification will be quantified in measured wear life comparisons.

Measurement in Sensory Modulation: The Sensory Processing Scale Assessment

PubMed Central

Miller, Lucy J.; Sullivan, Jillian C.

2014-01-01

OBJECTIVE. Sensory modulation issues have a significant impact on participation in daily life. Moreover, understanding phenotypic variation in sensory modulation dysfunction is crucial for research related to defining homogeneous groups and for clinical work in guiding treatment planning. We thus evaluated the new Sensory Processing Scale (SPS) Assessment. METHOD. Research included item development, behavioral scoring system development, test administration, and item analyses to evaluate reliability and validity across sensory domains. RESULTS. Items with adequate reliability (internal reliability >.4) and discriminant validity (p < .01) were retained. Feedback from the expert panel also contributed to decisions about retaining items in the scale. CONCLUSION. The SPS Assessment appears to be a reliable and valid measure of sensory modulation (scale reliability >.90; discrimination between group effect sizes >1.00). This scale has the potential to aid in differential diagnosis of sensory modulation issues. PMID:25184464

Current methodological issues in the economic assessment of personalized medicine.

PubMed

Annemans, Lieven; Redekop, Ken; Payne, Katherine

2013-01-01

There is a need for methodological scrutiny in the economic assessment of personalized medicine. In this article, we present a list of 10 specific issues that we argue pose specific methodological challenges that require careful consideration when designing and conducting robust model-based economic evaluations in the context of personalized medicine. Key issues are related to the correct framing of the research question, interpretation of test results, data collection of medical management options after obtaining test results, and expressing the value of tests. The need to formulate the research question clearly and be explicit and specific about the technology being evaluated is essential because various test kits can have the same purpose and yet differ in predictive value, costs, and relevance to practice and patient populations. The correct reporting of sensitivity/specificity, and especially the false negatives and false positives (which are population dependent), of the investigated tests is also considered as a key element. This requires additional structural complexity to establish the relationship between the test result and the consecutive treatment changes and outcomes. This process involves translating the test characteristics into clinical utility, and therefore outlining the clinical and economic consequences of true and false positives and true and false negatives. Information on treatment patterns and on their costs and outcomes, however, is often lacking, especially for false-positive and false-negative test results. The analysis can even become very complex if different tests are combined or sequentially used. This potential complexity can be handled by explicitly showing how these tests are going to be used in practice and then working with the combined sensitivities and specificities of the tests. Each of these issues leads to a higher degree of uncertainty in economic models designed to assess the added value of personalized medicine compared with their simple pharmaceutical counterparts. To some extent, these problems can be overcome by performing early population-level simulations, which can lead to the identification and collection of data on critical input parameters. Finally, it is important to understand that a test strategy does not necessarily lead to more quality-adjusted life-years (QALYs). It is possible that the test will lead to not only fewer QALYs but also fewer costs, which can be defined as "decremental" cost per QALYs. Different decision criteria are needed to interpret such results. © 2013 Published by Elsevier Inc. on behalf of International Society for Pharmacoeconomics and Outcomes Research (ISPOR).

Marriage and Family Therapy and Traditional Counselor Education Programs.

ERIC Educational Resources Information Center

Beamish, Patricia; Navin, Sally

This document presents a review of the literature on salient ethical issues in marriage and family counseling. Issues addressed in the paper include: (1) defining the client and the welfare and rights of individuals versus those of the family system; (2) issues of informed consent and manipulative therapeutic interventions; (3) issues related to…

Laboratory testing of candidate robotic applications for space

NASA Technical Reports Server (NTRS)

Purves, R. B.

1987-01-01

Robots have potential for increasing the value of man's presence in space. Some categories with potential benefit are: (1) performing extravehicular tasks like satellite and station servicing, (2) supporting the science mission of the station by manipulating experiment tasks, and (3) performing intravehicular activities which would be boring, tedious, exacting, or otherwise unpleasant for astronauts. An important issue in space robotics is selection of an appropriate level of autonomy. In broad terms three levels of autonomy can be defined: (1) teleoperated - an operator explicitly controls robot movement; (2) telerobotic - an operator controls the robot directly, but by high-level commands, without, for example, detailed control of trajectories; and (3) autonomous - an operator supplies a single high-level command, the robot does all necessary task sequencing and planning to satisfy the command. Researchers chose three projects for their exploration of technology and implementation issues in space robots, one each of the three application areas, each with a different level of autonomy. The projects were: (1) satellite servicing - teleoperated; (2) laboratory assistant - telerobotic; and (3) on-orbit inventory manager - autonomous. These projects are described and some results of testing are summarized.

Pendulum test measure correlates with gait parameters in children with cerebral palsy.

PubMed

Lotfian, M; Mirbagheri, M M; Kharazi, M R; Dadashi, F; Nourian, R; Irani, A; Mirbagheri, A

2016-08-01

Individuals with cerebral palsy (CP) usually suffer from different impairments including gait impairment and spasticity. Spastic hypertonia is a defining feature of spasticity and manifests as a mechanical abnormality. The objective of this study was to determine the relationship between spastic hypertonia and gait impairments in spastic children with CP, addressing an important controversial issue. Spastic hypertonia was quantified using the pendulum test. The gait impairments were evaluated using the motion capture system in a gait laboratory. Our results showed significant correlations among gait parameters; i.e. walking speed, step length, and the pendulum test measures. This indicates that neuromuscular abnormalities are associated with spasticity and may contribute to gait impairments. The clinical implication is that the impaired gait in children with CP may be improved with the treatment of neuromuscular abnormalities.

Effects of space environment on composites: An analytical study of critical experimental parameters

NASA Technical Reports Server (NTRS)

Gupta, A.; Carroll, W. F.; Moacanin, J.

1979-01-01

A generalized methodology currently employed at JPL, was used to develop an analytical model for effects of high-energy electrons and interactions between electron and ultraviolet effects. Chemical kinetic concepts were applied in defining quantifiable parameters; the need for determining short-lived transient species and their concentration was demonstrated. The results demonstrates a systematic and cost-effective means of addressing the issues and show qualitative and quantitative, applicable relationships between space radiation and simulation parameters. An equally important result is identification of critical initial experiments necessary to further clarify the relationships. Topics discussed include facility and test design; rastered vs. diffuse continuous e-beam; valid acceleration level; simultaneous vs. sequential exposure to different types of radiation; and interruption of test continuity.

Defining a Road Safety Audits Program for Enhancing Safety and Reducing Tort Liability

DOT National Transportation Integrated Search

2000-07-01

Table of Contents: (1) Introduction; (2) Review of Safety Issues; (3) Review of Legal Liability Issues; (4) Summary of Safety and Legal Liability Issues. Prepared in cooperation with Wyoming Univ., Laramie. Dept. of Civil and Architectural Engineerin...

Cloud Security: Issues and Research Directions

DTIC Science & Technology

2014-11-18

4. Cloud Computing Security: What Changes with Software - Defined Networking ? Maur´ıcio Tsugawa, Andr´ea Matsunaga, and Jos´e A. B. Fortes 5...machine’s memory from an untrusted or malicious hypervisor. In Chapter 4, Tsugawa et al. discuss the security issues introduced when Software - Defined ... Networking ( SDN ) is deployed within and across clouds. Chapters 5-9 are focused on the protection of data stored in the cloud. In Chapter 5, Wang et

Chemistry, toxicity, and bioavailability of copper and its relationship to regulation in the marine environment. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seligman, P.E.; Zirino, A.

1998-11-01

This document details issues addressed at a June 1997 workshop attended by Navy and regulatory representatives and scientific experts. Objectives discussed were: (1) define the current status and future direction of copper (Cu) regulations, (2) define problems and issues associated with the introduction of copper into the estuarine environment, and (3) discuss and evaluate the relationship between copper speciation, bio-availability, and toxicity.

Design and analysis issues of integrated control systems for high-speed civil transports

NASA Technical Reports Server (NTRS)

Mccarty, Craig A.; Feather, John B.; Dykman, John R.; Page, Mark A.; Hodgkinson, John

1992-01-01

A study was conducted to identify, rank, and define development plans for the critical guidance and control design and analysis issues as related to economically viable and environmentally acceptable high-speed civil transport. The issues were identified in a multistep process. First, pertinent literature on supersonic cruise aircraft was reviewed, and experts were consulted to establish the fundamental characteristics and problems inherent to supersonic cruise aircraft. Next, the advanced technologies and strategies being pursued for the high-speed civil transport were considered to determine any additional unique control problems the transport may have. Finally, existing technologies and methods were examined to determine their capabilities for the design and analysis of high-speed civil transport control systems and to identify the shortcomings and issues. Three priority levels - mandatory, highly beneficial, and desirable - were established. Within each of these levels, the issues were further ranked. Technology development plans for each issue were defined. Each plan contains a task breakdown and schedule.

Media in Higher Education; The Critical Issues: Ideas, Analysis, Confrontation.

ERIC Educational Resources Information Center

1976

Nine issues papers were presented at the February 1976 Critical Issues Conference, the goal of which was to expose and define issues critical to the media field in higher education. Topics included definition and management of media programs, the role of media in the future of higher education, library media programs and instructional technology,…

Some controversial multiple testing problems in regulatory applications.

PubMed

Hung, H M James; Wang, Sue-Jane

2009-01-01

Multiple testing problems in regulatory applications are often more challenging than the problems of handling a set of mathematical symbols representing multiple null hypotheses under testing. In the union-intersection setting, it is important to define a family of null hypotheses relevant to the clinical questions at issue. The distinction between primary endpoint and secondary endpoint needs to be considered properly in different clinical applications. Without proper consideration, the widely used sequential gate keeping strategies often impose too many logical restrictions to make sense, particularly to deal with the problem of testing multiple doses and multiple endpoints, the problem of testing a composite endpoint and its component endpoints, and the problem of testing superiority and noninferiority in the presence of multiple endpoints. Partitioning the null hypotheses involved in closed testing into clinical relevant orderings or sets can be a viable alternative to resolving the illogical problems requiring more attention from clinical trialists in defining the clinical hypotheses or clinical question(s) at the design stage. In the intersection-union setting there is little room for alleviating the stringency of the requirement that each endpoint must meet the same intended alpha level, unless the parameter space under the null hypothesis can be substantially restricted. Such restriction often requires insurmountable justification and usually cannot be supported by the internal data. Thus, a possible remedial approach to alleviate the possible conservatism as a result of this requirement is a group-sequential design strategy that starts with a conservative sample size planning and then utilizes an alpha spending function to possibly reach the conclusion early.

Outcomes of an International Workshop on Preconception Expanded Carrier Screening: Some Considerations for Governments.

PubMed

Molster, Caron M; Lister, Karla; Metternick-Jones, Selina; Baynam, Gareth; Clarke, Angus John; Straub, Volker; Dawkins, Hugh J S; Laing, Nigel

2017-01-01

Consideration of expanded carrier screening has become an emerging issue for governments. However, traditional criteria for decision-making regarding screening programs do not incorporate all the issues relevant to expanded carrier screening. Further, there is a lack of consistent guidance in the literature regarding the development of appropriate criteria for government assessment of expanded carrier screening. Given this, a workshop was held to identify key public policy issues related to preconception expanded carrier screening, which governments should consider when deciding whether to publicly fund such programs. In June 2015, a satellite workshop was held at the European Society of Human Genetics Conference. It was structured around two design features: (1) the provision of information from a range of perspectives and (2) small group deliberations on the key issues that governments need to consider and the benefits, risks, and challenges of implementing publicly funded whole-population preconception carrier screening. Forty-one international experts attended the workshop. The deliberations centered primarily on the conditions to be tested and the elements of the screening program itself. Participants expected only severe conditions to be screened but were concerned about the lack of a consensus definition of "severe." Issues raised regarding the screening program included the purpose, benefits, harms, target population, program acceptability, components of a program, and economic evaluation. Participants also made arguments for consideration of the accuracy of screening tests. A wide range of issues require careful consideration by governments that want to assess expanded carrier screening. Traditional criteria for government decision-making regarding screening programs are not a "best fit" for expanded carrier screening and new models of decision-making with appropriate criteria are required. There is a need to define what a "severe" condition is, to build evidence regarding the reliability and accuracy of screening tests, to consider the equitable availability and downstream effects on and costs of follow-up interventions for those identified as carriers, and to explore the ways in which the components of a screening program would be impacted by unique features of expanded carrier screening.

Test Pricing and Reimbursement in Genomic Medicine: Towards a General Strategy.

PubMed

Vozikis, Athanassios; Cooper, David N; Mitropoulou, Christina; Kambouris, Manousos E; Brand, Angela; Dolzan, Vita; Fortina, Paolo; Innocenti, Federico; Lee, Ming Ta Michael; Leyens, Lada; Macek, Milan; Al-Mulla, Fahd; Prainsack, Barbara; Squassina, Alessio; Taruscio, Domenica; van Schaik, Ron H; Vayena, Effy; Williams, Marc S; Patrinos, George P

2016-01-01

This paper aims to provide an overview of the rationale and basic principles guiding the governance of genomic testing services, to clarify their objectives, and allocate and define responsibilities among stakeholders in a health-care system, with a special focus on the EU countries. Particular attention is paid to issues pertaining to pricing and reimbursement policies, the availability of essential genomic tests which differs between various countries owing to differences in disease prevalence and public health relevance, the prescribing and use of genomic testing services according to existing or new guidelines, budgetary and fiscal control, the balance between price and access to innovative testing, monitoring and evaluation for cost-effectiveness and safety, and the development of research capacity. We conclude that addressing the specific items put forward in this article will help to create a robust policy in relation to pricing and reimbursement in genomic medicine. This will contribute to an effective and sustainable health-care system and will prove beneficial to the economy at large. © 2016 S. Karger AG, Basel.

Specimen size effects on ductile?brittle transition temperature in Charpy impact testing

NASA Astrophysics Data System (ADS)

Kurishita, H.; Yamamoto, T.; Narui, M.; Suwarno, H.; Yoshitake, T.; Yano, Y.; Yamazaki, M.; Matsui, H.

2004-08-01

One key issue for small specimen test techniques is to clarify specimen size effects on test results. In consideration of size effects on determining the ductile-to-brittle transition temperature (DBTT) in Charpy impact testing, a method to evaluate the plastic constraint loss for differently sized Charpy V-notch (CVN) specimens is proposed and applied to a ferritic-martensitic steel, 2WFK, developed by JNC. In the method, a constraint factor, α, that is an index of the plastic constraint is defined as α=σ ∗/σ y∗. Here, σ ∗ is the critical cleavage fracture stress which is a material constant and σ y∗ is the uniaxial yield stress at the DBTT at the strain rate generated in the Charpy impact test. The procedures for evaluating each of σ ∗ and σ y∗ are described and a result of σ ∗ and σ y∗, thus the value of α, is presented for different types of miniaturized and full-sized CVN specimens of 2WFK.

Alternate Reductant Cold Cap Evaluation Furnace Phase II Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, F. C.; Stone, M. E.; Miller, D. H.

2014-09-03

Savannah River Remediation (SRR) conducted a Systems Engineering Evaluation (SEE) to determine the optimum alternate reductant flowsheet for the Defense Waste Processing Facility (DWPF). Specifically, two proposed flowsheets (nitric–formic–glycolic and nitric–formic–sugar) were evaluated based upon results from preliminary testing. Comparison of the two flowsheets among evaluation criteria indicated a preference towards the nitric–formic–glycolic flowsheet. Further research and development of this flowsheet eliminated the formic acid, and as a result, the nitric–glycolic flowsheet was recommended for further testing. Based on the development of a roadmap for the nitric–glycolic acid flowsheet, Waste Solidification Engineering (WS-E) issued a Technical Task Request (TTR) tomore » address flammability issues that may impact the implementation of this flowsheet. Melter testing was requested in order to define the DWPF flammability envelope for the nitric-glycolic acid flowsheet. The Savannah River National Laboratory (SRNL) Cold Cap Evaluation Furnace (CEF), a 1/12 th scale DWPF melter, was selected by the SRR Alternate Reductant project team as the melter platform for this testing. The overall scope was divided into the following sub-tasks as discussed in the Task Technical and Quality Assurance Plan (TTQAP): Phase I - A nitric–formic acid flowsheet melter test (unbubbled) to baseline the CEF cold cap and vapor space data to the benchmark melter flammability models; Phase II - A nitric–glycolic acid flowsheet melter test (unbubbled and bubbled) to: Define new cold cap reactions and global kinetic parameters in support of the melter flammability model development; Quantify off-gas surging potential of the feed; Characterize off-gas condensate for complete organic and inorganic carbon species. After charging the CEF with cullet from Phase I CEF testing, the melter was slurry-fed with glycolic flowsheet based SB6-Frit 418 melter feed at 36% waste loading and was operated continuously for 25 days. Process data was collected throughout testing and included melter operation parameters and off-gas chemistry. In order to generate off-gas data in support of the flammability model development for the nitric-glycolic flowsheet, vapor space steady state testing in the range of ~300-750°C was conducted under the following conditions, (i) 100% (nominal and excess antifoam levels) and 125% stoichiometry feed and (ii) with and without argon bubbling. Adjustments to feed rate, heater outputs and purge air flow were necessary in order to achieve vapor space temperatures in this range. Surge testing was also completed under nominal conditions for four days with argon bubbling and one day without argon bubbling.« less

Direct-to-consumer genetic testing for predicting sports performance and talent identification: Consensus statement.

PubMed

Webborn, Nick; Williams, Alun; McNamee, Mike; Bouchard, Claude; Pitsiladis, Yannis; Ahmetov, Ildus; Ashley, Euan; Byrne, Nuala; Camporesi, Silvia; Collins, Malcolm; Dijkstra, Paul; Eynon, Nir; Fuku, Noriyuki; Garton, Fleur C; Hoppe, Nils; Holm, Søren; Kaye, Jane; Klissouras, Vassilis; Lucia, Alejandro; Maase, Kamiel; Moran, Colin; North, Kathryn N; Pigozzi, Fabio; Wang, Guan

2015-12-01

The general consensus among sport and exercise genetics researchers is that genetic tests have no role to play in talent identification or the individualised prescription of training to maximise performance. Despite the lack of evidence, recent years have witnessed the rise of an emerging market of direct-to-consumer marketing (DTC) tests that claim to be able to identify children's athletic talents. Targeted consumers include mainly coaches and parents. There is concern among the scientific community that the current level of knowledge is being misrepresented for commercial purposes. There remains a lack of universally accepted guidelines and legislation for DTC testing in relation to all forms of genetic testing and not just for talent identification. There is concern over the lack of clarity of information over which specific genes or variants are being tested and the almost universal lack of appropriate genetic counselling for the interpretation of the genetic data to consumers. Furthermore independent studies have identified issues relating to quality control by DTC laboratories with different results being reported from samples from the same individual. Consequently, in the current state of knowledge, no child or young athlete should be exposed to DTC genetic testing to define or alter training or for talent identification aimed at selecting gifted children or adolescents. Large scale collaborative projects, may help to develop a stronger scientific foundation on these issues in the future. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

A topo-graph model for indistinct target boundary definition from anatomical images.

PubMed

Cui, Hui; Wang, Xiuying; Zhou, Jianlong; Gong, Guanzhong; Eberl, Stefan; Yin, Yong; Wang, Lisheng; Feng, Dagan; Fulham, Michael

2018-06-01

It can be challenging to delineate the target object in anatomical imaging when the object boundaries are difficult to discern due to the low contrast or overlapping intensity distributions from adjacent tissues. We propose a topo-graph model to address this issue. The first step is to extract a topographic representation that reflects multiple levels of topographic information in an input image. We then define two types of node connections - nesting branches (NBs) and geodesic edges (GEs). NBs connect nodes corresponding to initial topographic regions and GEs link the nodes at a detailed level. The weights for NBs are defined to measure the similarity of regional appearance, and weights for GEs are defined with geodesic and local constraints. NBs contribute to the separation of topographic regions and the GEs assist the delineation of uncertain boundaries. Final segmentation is achieved by calculating the relevance of the unlabeled nodes to the labels by the optimization of a graph-based energy function. We test our model on 47 low contrast CT studies of patients with non-small cell lung cancer (NSCLC), 10 contrast-enhanced CT liver cases and 50 breast and abdominal ultrasound images. The validation criteria are the Dice's similarity coefficient and the Hausdorff distance. Student's t-test show that our model outperformed the graph models with pixel-only, pixel and regional, neighboring and radial connections (p-values <0.05). Our findings show that the topographic representation and topo-graph model provides improved delineation and separation of objects from adjacent tissues compared to the tested models. Copyright © 2018 Elsevier B.V. All rights reserved.

A Defense of Argument as Disagreement.

ERIC Educational Resources Information Center

Benoit, Pamela J.

1991-01-01

Rejects Robert Rowland and J. Kevin Barge's conclusion (in an article in the same issue) that defining argument as reason giving is superior to defining argument as disagreement. Maintains that defining argument as disagreement is appropriate for an interpretive argumentation theorist, and that argumentation is a complex topic with room for more…

29 CFR 1910.1096 - Ionizing radiation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... material, as defined in the Atomic Energy Act of 1954, as amended, under a license issued by the Nuclear... material, byproduct material, or special nuclear material, as defined in the Atomic Energy Act of 1954, as... source material, byproduct material, or special nuclear material, as defined in the Atomic Energy Act of...

29 CFR 1910.1096 - Ionizing radiation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... material, as defined in the Atomic Energy Act of 1954, as amended, under a license issued by the Nuclear... material, byproduct material, or special nuclear material, as defined in the Atomic Energy Act of 1954, as... source material, byproduct material, or special nuclear material, as defined in the Atomic Energy Act of...

29 CFR 1910.1096 - Ionizing radiation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... material, as defined in the Atomic Energy Act of 1954, as amended, under a license issued by the Nuclear... material, byproduct material, or special nuclear material, as defined in the Atomic Energy Act of 1954, as... source material, byproduct material, or special nuclear material, as defined in the Atomic Energy Act of...

Clarifying and Defining Library Services.

ERIC Educational Resources Information Center

Shubert, Joseph F., Ed.; Josey, E. J., Ed.

1991-01-01

This issue presents articles which, in some way, help to clarify and define library services. It is hoped that this clarification in library service will serve to secure the resources libraries need to serve the people of New York. The following articles are presented: (1) Introduction: "Clarifying and Defining Library Services" (Joseph…

Optimal management of adults with pharyngitis – a multi-criteria decision analysis

PubMed Central

Singh, Sonal; Dolan, James G; Centor, Robert M

2006-01-01

Background Current practice guidelines offer different management recommendations for adults presenting with a sore throat. The key issue is the extent to which the clinical likelihood of a Group A streptococcal infection should affect patient management decisions. To help resolve this issue, we conducted a multi-criteria decision analysis using the Analytic Hierarchy Process. Methods We defined optimal patient management using four criteria: 1) reduce symptom duration; 2) prevent infectious complications, local and systemic; 3) minimize antibiotic side effects, minor and anaphylaxis; and 4) achieve prudent use of antibiotics, avoiding both over-use and under-use. In our baseline analysis we assumed that all criteria and sub-criteria were equally important except minimizing anaphylactic side effects, which was judged very strongly more important than minimizing minor side effects. Management strategies included: a) No test, No treatment; b) Perform a rapid strep test and treat if positive; c) Perform a throat culture and treat if positive; d) Perform a rapid strep test and treat if positive; if negative obtain a throat culture and treat if positive; and e) treat without further tests. We defined four scenarios based on the likelihood of group A streptococcal infection using the Centor score, a well-validated clinical index. Published data were used to estimate the likelihoods of clinical outcomes and the test operating characteristics of the rapid strep test and throat culture for identifying group A streptococcal infections. Results Using the baseline assumptions, no testing and no treatment is preferred for patients with Centor scores of 1; two strategies – culture and treat if positive and rapid strep with culture of negative results – are equally preferable for patients with Centor scores of 2; and rapid strep with culture of negative results is the best management strategy for patients with Centor scores 3 or 4. These results are sensitive to the priorities assigned to the decision criteria, especially avoiding over-use versus under-use of antibiotics, and the population prevalence of Group A streptococcal pharyngitis. Conclusion The optimal clinical management of adults with sore throat depends on both the clinical probability of a group A streptococcal infection and clinical judgments that incorporate individual patient and practice circumstances. PMID:16533386

Protein-RNA specificity by high-throughput principal component analysis of NMR spectra.

PubMed

Collins, Katherine M; Oregioni, Alain; Robertson, Laura E; Kelly, Geoff; Ramos, Andres

2015-03-31

Defining the RNA target selectivity of the proteins regulating mRNA metabolism is a key issue in RNA biology. Here we present a novel use of principal component analysis (PCA) to extract the RNA sequence preference of RNA binding proteins. We show that PCA can be used to compare the changes in the nuclear magnetic resonance (NMR) spectrum of a protein upon binding a set of quasi-degenerate RNAs and define the nucleobase specificity. We couple this application of PCA to an automated NMR spectra recording and processing protocol and obtain an unbiased and high-throughput NMR method for the analysis of nucleobase preference in protein-RNA interactions. We test the method on the RNA binding domains of three important regulators of RNA metabolism. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

The Ascension Island hydroacoustic experiment: purpose, data set features and plans for future analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harben, P E; Rock, D; Rodgers, A J

1999-07-23

Calibration of hydroacoustic and T-phase stations for Comprehensive Nuclear-Test-Ban Treaty (CTBT) monitoring will be an important element in establishing new operational stations and upgrading existing stations. Calibration of hydroacoustic stations is herein defined as precision location of the hydrophones and determination of the amplitude response from a known source energy. T-phase station calibration is herein defined as a determination of station site attenuation as a function of frequency, bearing, and distance for known impulsive energy sources in the ocean. To understand how to best conduct calibration experiments for both hydroacoustic and T-phase stations, an experiment was conducted in May, 1999more » at Ascension Island in the South Atlantic Ocean. The experiment made use of a British oceanographic research vessel and collected data that will be used for CTBT issues and for fundamental understanding of the Ascension Island volcanic edifice.« less

Introduction to Mars Sampling Handling Workshop Series. Workshop on Life Detection: Issues and Topics

NASA Technical Reports Server (NTRS)

Rummel, John D.

2001-01-01

Before martian soil and rock samples can be distributed to the research community, the returned materials will initially be quarantined and examined in a proposed BSL-4 containment facility to assure that no putative martian microorganisms or attendant potential biohazards exist. During the initial quarantine, state-of-the-art life detection and biohazard testing of the returned martian samples will be conducted. Life detection, as defined here in regard to Mars sample return missions, is the detection of living organisms and/or materials that have been derived from living organisms that may be present in the sample.

NASA Johnson Space Center Biomedical Research Resources

NASA Technical Reports Server (NTRS)

Paloski, W. H.

1999-01-01

Johnson Space Center (JSC) medical sciences laboratories constitute a national resource for support of medical operations and life sciences research enabling a human presence in space. They play a critical role in evaluating, defining, and mitigation the untoward effect of human adaption to space flight. Over the years they have developed the unique facilities and expertise required to perform: biomedical sample analysis and physiological performance tests supporting medical evaluations of space flight crew members and scientific investigations of the operationally relevant medical, physiological, cellular, and biochemical issues associated with human space flight. A general overview of these laboratories is presented in viewgraph form.

A social-ecological systems approach for environmental management.

PubMed

Virapongse, Arika; Brooks, Samantha; Metcalf, Elizabeth Covelli; Zedalis, Morgan; Gosz, Jim; Kliskey, Andrew; Alessa, Lilian

2016-08-01

Urgent environmental issues are testing the limits of current management approaches and pushing demand for innovative approaches that integrate across traditional disciplinary boundaries. Practitioners, scholars, and policy-makers alike call for increased integration of natural and social sciences to develop new approaches that address the range of ecological and societal impacts of modern environmental issues. From a theoretical perspective, social-ecological systems (SES) science offers a compelling approach for improved environmental management through the application of transdisciplinary and resilience concepts. A framework for translating SES theory into practice, however, is lacking. In this paper, we define the key components of an SES-based environmental management approach. We offer recommendations for integrating an SES approach into existing environmental management practices. Results presented are useful for management professionals that seek to employ an SES environmental management approach and scholars aiming to advance the theoretical foundations of SES science for practical application. Published by Elsevier Ltd.

Properties of a center/surround retinex. Part 2: Surround design

NASA Technical Reports Server (NTRS)

Jobson, Daniel J.; Woodell, Glenn A.

1995-01-01

The last version of Edwin Land's retinex model for human vision's lightness and color constancy has been implemented. Previous research has established the mathematical foundations of Land's retinex but has not examined specific design issues and their effects on the properties of the retinex operation. We have sought to define a practical implementation of the retinex without particular concern for its validity as a model for human lightness and color perception. Here we describe issues involved in designing the surround function. We find that there is a trade-off between rendition and dynamic range compression that is governed by the surround space constant. Various functional forms for the retinex surround are evaluated and a Gaussian form is found to perform better than the inverse square suggested by Land. Preliminary testing led to the design of a Gaussian surround with a space constant of 80 pixels as a reasonable compromise between dynamic range compression and rendition.

Active Learning in a Neuroethics Course Positively Impacts Moral Judgment Development in Undergraduates

PubMed Central

Abu-Odeh, Desiree; Dziobek, Derek; Jimenez, Nathalia Torres; Barbey, Christopher; Dubinsky, Janet M

2015-01-01

The growing neuroscientific understanding of the biological basis of behaviors has profound social and ethical implications. To address the need for public awareness of the consequences of these advances, we developed an undergraduate neuroethics course, Neuroscience and Society, at the University of Minnesota. Course evolution, objectives, content, and impact are described here. To engage all students and facilitate undergraduate ethics education, this course employed daily reading, writing, and student discussion, case analysis, and team presentations with goals of fostering development of moral reasoning and judgment and introducing application of bioethical frameworks to topics raised by neuroscience. Pre- and post-course Defining Issues Test (DIT) scores and student end-of-course reflections demonstrated that course objectives for student application of bioethical frameworks to neuroethical issues were met. The active-learning, student-centered pedagogical approaches used to achieve these goals serve as a model for how to effectively teach neuroethics at the undergraduate level. PMID:25838802

Power, Profits, and Politics: Energy Security and Cooperation in Eurasia

NASA Astrophysics Data System (ADS)

Svyatets, Ekaterina

This study explores varying outcomes of energy cooperation, defined as diplomatic relations, bilateral trade, and investment in oil and natural gas. Tests of theories pertinent to energy security - broadly speaking, realism, liberalism, and domestic politics---reveal that they alone can offer only a narrow and one-sided explanation, not embracing the complexity of energy issues. Nevertheless, using them as a starting point, this study outlined a structured framework that incorporates three variables---economic potential, geopolitical rivalry, and domestic interest groups---that are applied to the cases of U.S.-Russia, U.S.-Azerbaijan, and Russia-Germany energy ties. This study concludes that if the economic potential (defined by geographic proximity and resource availability) is very high, such as in the case of Russia-Germany, states can overcome geopolitical rivalries and historical enmities in favor of energy cooperation. However, if the economic potential is relatively low (because of geographic obstacles or easily available alternative suppliers, as in the cases of U.S.-Russia and U.S.-Azerbaijan), then geopolitics prevails---for example, to bypass Russia or to limit American access to contracts in Russia when U.S.-Russian relations are strained. In all the cases explored here, domestic interest groups have mixed influence: if they are united along energy issues, they usually successfully achieve their energy policy goals, although the impact of these groups often becomes intertwined with state interests. In other situations, when powerful interest groups are divided or focused on non-energy-related issues (such as ethnic priorities), their influence over energy deals is much lower.

Theme Issue on Classroom Communication.

ERIC Educational Resources Information Center

Anapol, Malthon M., Ed.

1979-01-01

The first article in this journal issue offers a diffuse definition of instructional communication, the theme of the issue, and reviews literature that points out the ill-defined parameters of communication and the classroom. The following articles discuss the development of a rhetorical perspective on teaching, the parental role in facilitating…

Defining the Issues of a Presidential Election from Televised Political Spot Advertisements.

ERIC Educational Resources Information Center

Shyles, Leonard C.

1983-01-01

Discerns issues of the 1980 presidential primary campaigns through content analysis of issues presented in televised political spot advertisements created for nine presidential primary candidates. Results indicate Democrats were most concerned with the economy, energy, foreign policy, and national security, while Republicans focused on federalism…

Legal Issues in Teacher Evaluation. Handbook.

ERIC Educational Resources Information Center

Educational Testing Service, Princeton, NJ.

Various legal issues associated with teacher evaluation and significant court decisions are summarized in this handbook. Three major legal issues are defined: (1) failure of the school district to follow due process when terminating tenured and non-tenured teachers, or when abolishing positions; (2) discrimination in employment and promotion, or…

The Coverage Issue

ERIC Educational Resources Information Center

Yoshinobu, Stan; Jones, Matthew G.

2012-01-01

A significant issue mathematics instructors face is how to cover all the material. Mathematics teachers of all levels have some external and internal pressures to "get through" all the required material. The authors define "the coverage issue" to be the set of difficulties that arise in attempting to cover a lengthy list of topics. Principal among…

Native Americans and the Environment: A Survey of Twentieth-Century Issues.

ERIC Educational Resources Information Center

Lewis, David Rich

1995-01-01

Land; exploitation of land; and changing Indian needs, attitudes, and religious demands define environmental issues facing modern Native Americans. Such issues are related to agriculture and ranching, forests and watersheds, hunting and fishing, water, natural resource mining and pollution, hazardous and radioactive waste storage, urbanization of…

The Role of Issue Familiarity And Social Norms: Findings on New College Students’ Alcohol Use Intentions

PubMed Central

Rimal, Rajiv N.; Mollen, Saar

2013-01-01

Background Scholars in a variety of disciplines are interested in understanding the conditions under which social norms affect human behavior. Following the distinction made between descriptive and injunctive norms by the focus theory of normative conduct, the theory of normative social behavior predicts that the influence of descriptive norms on behavior is moderated by injunctive norms, outcome expectations, and group identity. We extended the theory by testing the proposition that the influence of descriptive norms on behavior would be greater under conditions of greater issue familiarity, defined as the ease with which one can cognitively access the behavior or behavioral issue. Design and Methods The model was tested in the domain of alcohol consumption intentions by conducting a survey among incoming students (n=719) to a large university in the United States. Data indicated that students in the sample were well representative of the university population. Results The influence of descriptive norms on behavioral intentions was moderated by issue familiarity, as predicted. Familiarity was a facilitator of behavior: the influence of descriptive norms on behavioral intentions was greater under conditions of high, rather than low, familiarity. The overall model explained 53% of the variance in alcohol consumption intentions. Conclusions Public health interventions promoting health behaviors need to take into account the extent to which the behaviors are familiar to the target audience. The influence of norms appears to be weaker when the behavior is unfamiliar or novel. Implications for theory and interventions for reducing alcohol consumption are discussed. PMID:25170478

An Ethical Issue Scale for Community Pharmacy Setting (EISP): Development and Validation.

PubMed

Crnjanski, Tatjana; Krajnovic, Dusanka; Tadic, Ivana; Stojkov, Svetlana; Savic, Mirko

2016-04-01

Many problems that arise when providing pharmacy services may contain some ethical components and the aims of this study were to develop and validate a scale that could assess difficulties of ethical issues, as well as the frequency of those occurrences in everyday practice of community pharmacists. Development and validation of the scale was conducted in three phases: (1) generating items for the initial survey instrument after qualitative analysis; (2) defining the design and format of the instrument; (3) validation of the instrument. The constructed Ethical Issue scale for community pharmacy setting has two parts containing the same 16 items for assessing the difficulty and frequency thereof. The results of the 171 completely filled out scales were analyzed (response rate 74.89%). The Cronbach's α value of the part of the instrument that examines difficulties of the ethical situations was 0.83 and for the part of the instrument that examined frequency of the ethical situations was 0.84. Test-retest reliability for both parts of the instrument was satisfactory with all Interclass correlation coefficient (ICC) values above 0.6, (for the part that examines severity ICC = 0.809, for the part that examines frequency ICC = 0.929). The 16-item scale, as a self assessment tool, demonstrated a high degree of content, criterion, and construct validity and test-retest reliability. The results support its use as a research tool to asses difficulty and frequency of ethical issues in community pharmacy setting. The validated scale needs to be further employed on a larger sample of pharmacists.

A range/depth modulation transfer function (RMTF) framework for characterizing 3D imaging LADAR performance

NASA Astrophysics Data System (ADS)

Staple, Bevan; Earhart, R. P.; Slaymaker, Philip A.; Drouillard, Thomas F., II; Mahony, Thomas

2005-05-01

3D imaging LADARs have emerged as the key technology for producing high-resolution imagery of targets in 3-dimensions (X and Y spatial, and Z in the range/depth dimension). Ball Aerospace & Technologies Corp. continues to make significant investments in this technology to enable critical NASA, Department of Defense, and national security missions. As a consequence of rapid technology developments, two issues have emerged that need resolution. First, the terminology used to rate LADAR performance (e.g., range resolution) is inconsistently defined, is improperly used, and thus has become misleading. Second, the terminology does not include a metric of the system"s ability to resolve the 3D depth features of targets. These two issues create confusion when translating customer requirements into hardware. This paper presents a candidate framework for addressing these issues. To address the consistency issue, the framework utilizes only those terminologies proposed and tested by leading LADAR research and standards institutions. We also provide suggestions for strengthening these definitions by linking them to the well-known Rayleigh criterion extended into the range dimension. To address the inadequate 3D image quality metrics, the framework introduces the concept of a Range/Depth Modulation Transfer Function (RMTF). The RMTF measures the impact of the spatial frequencies of a 3D target on its measured modulation in range/depth. It is determined using a new, Range-Based, Slanted Knife-Edge test. We present simulated results for two LADAR pulse detection techniques and compare them to a baseline centroid technique. Consistency in terminology plus a 3D image quality metric enable improved system standardization.

Sci-Fri AM: Quality, Safety, and Professional Issues 01: CPQR Technical Quality Control Suite Development including Quality Control Workload Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malkoske, Kyle; Nielsen, Michelle; Brown, Erika

A close partnership between the Canadian Partnership for Quality Radiotherapy (CPQR) and the Canadian Organization of Medical Physicist’s (COMP) Quality Assurance and Radiation Safety Advisory Committee (QARSAC) has resulted in the development of a suite of Technical Quality Control (TQC) Guidelines for radiation treatment equipment, that outline specific performance objectives and criteria that equipment should meet in order to assure an acceptable level of radiation treatment quality. The framework includes consolidation of existing guidelines and/or literature by expert reviewers, structured stages of public review, external field-testing and ratification by COMP. The adopted framework for the development and maintenance of themore » TQCs ensures the guidelines incorporate input from the medical physics community during development, measures the workload required to perform the QC tests outlined in each TQC, and remain relevant (i.e. “living documents”) through subsequent planned reviews and updates. This presentation will show the Multi-Leaf Linear Accelerator document as an example of how feedback and cross-national work to achieve a robust guidance document. During field-testing, each technology was tested at multiple centres in a variety of clinic environments. As part of the defined feedback, workload data was captured. This lead to average time associated with testing as defined in each TQC document. As a result, for a medium-sized centre comprising 6 linear accelerators and a comprehensive brachytherapy program, we evaluate the physics workload to 1.5 full-time equivalent physicist per year to complete all QC tests listed in this suite.« less

GROUND WATER SAMPLING ISSUES

EPA Science Inventory

Obtaining representative ground water samples is important for site assessment and
remedial performance monitoring objectives. Issues which must be considered prior to initiating a ground-water monitoring program include defining monitoring goals and objectives, sampling point...

Meeting Report: Validation of Toxicogenomics-Based Test Systems: ECVAM–ICCVAM/NICEATM Considerations for Regulatory Use

PubMed Central

Corvi, Raffaella; Ahr, Hans-Jürgen; Albertini, Silvio; Blakey, David H.; Clerici, Libero; Coecke, Sandra; Douglas, George R.; Gribaldo, Laura; Groten, John P.; Haase, Bernd; Hamernik, Karen; Hartung, Thomas; Inoue, Tohru; Indans, Ian; Maurici, Daniela; Orphanides, George; Rembges, Diana; Sansone, Susanna-Assunta; Snape, Jason R.; Toda, Eisaku; Tong, Weida; van Delft, Joost H.; Weis, Brenda; Schechtman, Leonard M.

2006-01-01

This is the report of the first workshop “Validation of Toxicogenomics-Based Test Systems” held 11–12 December 2003 in Ispra, Italy. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and organized jointly by ECVAM, the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). The primary aim of the workshop was for participants to discuss and define principles applicable to the validation of toxicogenomics platforms as well as validation of specific toxicologic test methods that incorporate toxicogenomics technologies. The workshop was viewed as an opportunity for initiating a dialogue between technologic experts, regulators, and the principal validation bodies and for identifying those factors to which the validation process would be applicable. It was felt that to do so now, as the technology is evolving and associated challenges are identified, would be a basis for the future validation of the technology when it reaches the appropriate stage. Because of the complexity of the issue, different aspects of the validation of toxicogenomics-based test methods were covered. The three focus areas include a) biologic validation of toxicogenomics-based test methods for regulatory decision making, b) technical and bioinformatics aspects related to validation, and c) validation issues as they relate to regulatory acceptance and use of toxicogenomics-based test methods. In this report we summarize the discussions and describe in detail the recommendations for future direction and priorities. PMID:16507466

Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.

PubMed

Corvi, Raffaella; Ahr, Hans-Jürgen; Albertini, Silvio; Blakey, David H; Clerici, Libero; Coecke, Sandra; Douglas, George R; Gribaldo, Laura; Groten, John P; Haase, Bernd; Hamernik, Karen; Hartung, Thomas; Inoue, Tohru; Indans, Ian; Maurici, Daniela; Orphanides, George; Rembges, Diana; Sansone, Susanna-Assunta; Snape, Jason R; Toda, Eisaku; Tong, Weida; van Delft, Joost H; Weis, Brenda; Schechtman, Leonard M

2006-03-01

This is the report of the first workshop "Validation of Toxicogenomics-Based Test Systems" held 11-12 December 2003 in Ispra, Italy. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and organized jointly by ECVAM, the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). The primary aim of the workshop was for participants to discuss and define principles applicable to the validation of toxicogenomics platforms as well as validation of specific toxicologic test methods that incorporate toxicogenomics technologies. The workshop was viewed as an opportunity for initiating a dialogue between technologic experts, regulators, and the principal validation bodies and for identifying those factors to which the validation process would be applicable. It was felt that to do so now, as the technology is evolving and associated challenges are identified, would be a basis for the future validation of the technology when it reaches the appropriate stage. Because of the complexity of the issue, different aspects of the validation of toxicogenomics-based test methods were covered. The three focus areas include a) biologic validation of toxicogenomics-based test methods for regulatory decision making, b) technical and bioinformatics aspects related to validation, and c) validation issues as they relate to regulatory acceptance and use of toxicogenomics-based test methods. In this report we summarize the discussions and describe in detail the recommendations for future direction and priorities.

26 CFR 1.163-3 - Deduction for discount on bond issued on or before May 27, 1969.

Code of Federal Regulations, 2010 CFR

2010-04-01

... case of a callable bond, at the earlier call date) over the issue price of the bond (as defined in... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Deduction for discount on bond issued on or... and Corporations § 1.163-3 Deduction for discount on bond issued on or before May 27, 1969. (a...

DNA banking and DNA databanking by academic and commercial laboratories

DOE Office of Scientific and Technical Information (OSTI.GOV)

McEwen, J.E.; Reilly, P.R.

The advent of DNA-based testing is giving rise to DNA banking (the long-term storage of cells, transformed cell lines, or extracted DNA for subsequent retrieval and analysis) and DNA data banking (the indefinite storage of information derived from DNA analysis). Large scale acquisition and storage of DNA and DNA data has important implications for the privacy rights of individuals. A survey of 148 academically based and commercial DNA diagnostic laboratories was conducted to determine: (1) the extent of their DNA banking activities; (2) their policies and experiences regarding access to DNA samples and data; (3) the quality assurance measures theymore » employ; and (4) whether they have written policies and/or depositor`s agreements addressing specific issues. These issues include: (1) who may have access to DNA samples and data; (2) whether scientists may have access to anonymous samples or data for research use; (3) whether they have plans to contact depositors or retest samples if improved tests for a disorder become available; (4) disposition of samples at the end of the contract period if the laboratory ceases operations, if storage fees are unpaid, or after a death or divorce; (5) the consequence of unauthorized release, loss, or accidental destruction of samples; and (6) whether depositors may share in profits from the commercialization of tests or treatments developed in part from studies of stored DNA. The results suggest that many laboratories are banking DNA, that many have already amassed a large number of samples, and that a significant number plan to further develop DNA banking as a laboratory service over the next two years. Few laboratories have developed written policies governing DNA banking, and fewer still have drafted documents that define the rights and obligations of the parties. There may be a need for increased regulation of DNA banking and DNA data banking and for better defined policies with respect to protecting individual privacy.« less

Application of LAC-type processes and concepts to nonrecreation management issues in protected areas

Treesearch

Linda Merigliano; David N. Cole; David J. Parsons

1997-01-01

When Limits of Acceptable Change concepts are applied to nonrecreational issues, two primary problems are encountered: (1) developing zoning schemes which are compatible when multiple issues are addressed, and (2) defining the desired condition and establishing measurable standards for ecosystem attributes which change in unpredictable ways. Approaches to overcome...

A Sound Education for All: Multicultural Issues in Music Education

ERIC Educational Resources Information Center

Johnson, Jr., Bob L.

2004-01-01

Establishing the legitimacy of the arts within the larger school curriculum is a defining issue in arts education. Within the context of this perennial challenge, this article examines two multicultural issues in music education: equal music education opportunity and the idiomatic hegemony of the Western classical tradition. Discussions of the…

26 CFR 1.148-1 - Definitions and elections.

Code of Federal Regulations, 2011 CFR

2011-04-01

... working capital expenditures to which the de minimis rule under § 1.148-6(d)(3)(ii)(A) applies, that carry... are in a commingled fund. De minimis amount means— (1) In reference to original issue discount (as... proceeds of an issue. Investment-type property is defined in paragraph (e) of this section. Issue price...

Issues of Learning and Knowledge in Technology Education

ERIC Educational Resources Information Center

McCormick, Robert

2004-01-01

This article examines issues that arise from learning and knowledge in technology education. The issues examined are, first, the definition of technological knowledge and what the nature of that knowledge should be, where the concern is with "how" we define and think about that knowledge, especially in the context of how students learn and use…

15 CFR 766.24 - Temporary denials.

Code of Federal Regulations, 2011 CFR

2011-01-01

... temporary denial orders were issued. Without limiting any other action BIS may take under the EAR with..., as defined in this section, of the EAA, the EAR, or any order, license or authorization issued... provided for in § 764.3(a)(2) of the EAR. (b) Issuance. (1) The Assistant Secretary may issue an order...

15 CFR 766.24 - Temporary denials.

Code of Federal Regulations, 2012 CFR

2012-01-01

... temporary denial orders were issued. Without limiting any other action BIS may take under the EAR with..., as defined in this section, of the EAA, the EAR, or any order, license or authorization issued... provided for in § 764.3(a)(2) of the EAR. (b) Issuance. (1) The Assistant Secretary may issue an order...

15 CFR 766.24 - Temporary denials.

Code of Federal Regulations, 2014 CFR

2014-01-01

... temporary denial orders were issued. Without limiting any other action BIS may take under the EAR with..., as defined in this section, of the EAA, the EAR, or any order, license or authorization issued... provided for in § 764.3(a)(2) of the EAR. (b) Issuance. (1) The Assistant Secretary may issue an order...

15 CFR 766.24 - Temporary denials.

Code of Federal Regulations, 2013 CFR

2013-01-01

... temporary denial orders were issued. Without limiting any other action BIS may take under the EAR with..., as defined in this section, of the EAA, the EAR, or any order, license or authorization issued... provided for in § 764.3(a)(2) of the EAR. (b) Issuance. (1) The Assistant Secretary may issue an order...

15 CFR 766.24 - Temporary denials.

Code of Federal Regulations, 2010 CFR

2010-01-01

... temporary denial orders were issued. Without limiting any other action BIS may take under the EAR with..., as defined in this section, of the EAA, the EAR, or any order, license or authorization issued... provided for in § 764.3(a)(2) of the EAR. (b) Issuance. (1) The Assistant Secretary may issue an order...

Introduction: Religious and Spiritual Issues in Medical Genetics

PubMed Central

Fanning, Joseph B.; Clayton, Ellen Wright

2009-01-01

This article provides an overview of a special issue on the religious and spiritual concerns that arise in the provision of genetic services. It introduces some of the challenges in defining religion and spirituality and provides contexts and summaries for the empirical and normative research that appears in the issue. PMID:19170098

The hopelessness theory of depression: attributional aspects.

PubMed

Alloy, L B; Abramson, L Y; Metalsky, G I; Hartlage, S

1988-02-01

In this article, we clarify, expand and revise the basic postulates of the hopelessness theory of depression (Abramson, Alloy & Metalsky, 1988a; Abramson, Metalsky & Alloy, 1987, 1988b; previously referred to as the reformulated helplessness theory of depression: Abramson, Seligman & Teasdale, 1978) and place the theory more explicitly in the context of work in descriptive psychiatry about the heterogeneity among the depressive disorders. We suggest that the hopelessness theory hypothesizes the existence in nature of an, as yet, unidentified subtype of depression--'hopelessness depression'--defined, in part, by its cause. We then give a critique of work conducted to test the hopelessness theory and explicate the limitations in research strategy associated with this line of work. Our critique includes a logical analysis that deduces the conceptual and methodological inadequacies of the research strategies used to test the theory. Finally, we suggest more adequate research strategies for testing the hopelessness theory and discuss conceptual and assessment issues that will arise in conducting such tests with special emphasis on attributional styles.

How does substrate roughness affect the service life of a superhydrophobic coating?

NASA Astrophysics Data System (ADS)

Zhang, Xin; Mo, Jiliang; Si, Yifan; Guo, Zhiguang

2018-05-01

Although the development of superhydrophobic coatings is rapidly maturing, issues related to their low mechanical durability persist. In this context, the effect of substrate roughness on the service life of superhydrophobic coatings was studied. In this study, superhydrophobic coatings were fabricated on sandpapers of different roughness and reciprocating wear tests were conducted. The wear-resistance number of the superhydrophobic coating, defined as the maximum number of friction cycles after which the superhydrophobic surface started to lose its superhydrophobicity, increased from 50 to 24,000 with an increase in the substrate roughness from 2000 CW to 240 CW (CW is defined as the number of particles arranged in an inch), while it decreased from 24,000 to 17,000 with a further increase in the substrate roughness from 240 CW to 60 CW. Observations of the surface structure and wear analyses indicated that the superhydrophobic material infiltrated the spaces between the sand grains, and the rough peaks could consequently protect the superhydrophobic material during the wear tests. However, this protection weakens when the substrate roughness increases or decreases beyond certain values. Furthermore, these phenomena and results were also verified by applying the superhydrophobic coatings to different types of common substrates.

Blood bank on-call physician's experiences at a large university medical center.

PubMed

Bryant, Barbara J; Alperin, Jack B; Indrikovs, Alexander J

2005-01-01

The responsibilities of the blood bank on-call physician (blood bank physician from here on) encompass many aspects of transfusion medicine and physician education. This physician is available 24 hours a day to address any issues concerning the collection and transfusion of blood and blood components. The purpose of this study was to identify and categorize the issues that may confront a blood bank physician. Each call received over a 4-month period was logged and the resolution documented. The calls were grouped into five categories: donor issues, therapeutic procedure issues, patient issues, physician education issues, and requests for blood components not meeting previously defined transfusion guidelines. The blood bank physician received 224 calls during the study period. To resolve each issue, an additional 1 to 14 telephone calls were needed to gather further information. Number of calls by category were donor issues, 20 (8.9%); therapeutic procedure issues, 9 (4.0%); patient issues, 4 (1.8%); physician education issues, 33 (14.7%); and requests for blood components not meeting previously defined transfusion guidelines, 158 (70.6%). Requests for blood components were denied in 39.8 percent of the cases not meeting guidelines. Other forms of therapy were warranted in 20.9 percent of the cases. This study revealed that 85.3 percent of the calls referred to the blood bank physician related to physician education and the appropriateness of blood component orders. These results emphasize the need for ongoing education of medical staff in transfusion medicine issues.

Integrated Behavioral Z-Scoring Increases the Sensitivity and Reliability of Behavioral Phenotyping in mice: Relevance to Emotionality and Sex

PubMed Central

Guilloux, Jean-Philippe; Seney, Marianne; Edgar, Nicole; Sibille, Etienne

2011-01-01

Defining anxiety- and depressive-like states in mice (“emotionality”) is best characterized by the use of complementary tests, leading sometimes to puzzling discrepancies and lack of correlation between similar paradigms. To address this issue, we hypothesized that integrating measures along the same behavioral dimensions in different tests would reduce the intrinsic variability of single tests and provide a robust characterization of the underlying “emotionality” of individual mouse, similarly as mood and related syndromes are defined in humans through various related symptoms over time. We describe the use of simple mathematical and integrative tools to help phenotype animals across related behavioral tests (syndrome diagnosis) and experiments (meta-analysis). We applied z-normalization across complementary measures of emotionality in different behavioral tests after unpredictable chronic mild stress (UCMS) or prolonged corticosterone exposure - two approaches to induce anxious-/depressive-like states in mice. Combining z-normalized test values, lowered the variance of emotionality measurement, enhanced the reliability of behavioral phenotyping, and increased analytical opportunities. Comparing integrated emotionality scores across studies revealed a robust sexual dimorphism in the vulnerability to develop high emotionality, manifested as higher UCMS-induced emotionality z-scores, but lower corticosterone-induced scores in females compared to males. Interestingly, the distribution of individual z-scores revealed a pattern of increased baseline emotionality in female mice, reminiscent of what is observed in humans. Together, we show that the z-scoring method yields robust measures of emotionality across complementary tests for individual mice and experimental groups, hence facilitating the comparison across studies and refining the translational applicability of these models. PMID:21277897

Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: relevance to emotionality and sex.

PubMed

Guilloux, Jean-Philippe; Seney, Marianne; Edgar, Nicole; Sibille, Etienne

2011-04-15

Defining anxiety- and depressive-like states in mice (emotionality) is best characterized by the use of complementary tests, leading sometimes to puzzling discrepancies and lack of correlation between similar paradigms. To address this issue, we hypothesized that integrating measures along the same behavioral dimensions in different tests would reduce the intrinsic variability of single tests and provide a robust characterization of the underlying "emotionality" of individual mouse, similarly as mood and related syndromes are defined in humans through various related symptoms over time. We describe the use of simple mathematical and integrative tools to help phenotype animals across related behavioral tests (syndrome diagnosis) and experiments (meta-analysis). We applied z-normalization across complementary measures of emotionality in different behavioral tests after unpredictable chronic mild stress (UCMS) or prolonged corticosterone exposure - two approaches to induce anxious-/depressive-like states in mice. Combining z-normalized test values, lowered the variance of emotionality measurement, enhanced the reliability of behavioral phenotyping, and increased analytical opportunities. Comparing integrated emotionality scores across studies revealed a robust sexual dimorphism in the vulnerability to develop high emotionality, manifested as higher UCMS-induced emotionality z-scores, but lower corticosterone-induced scores in females compared to males. Interestingly, the distribution of individual z-scores revealed a pattern of increased baseline emotionality in female mice, reminiscent of what is observed in humans. Together, we show that the z-scoring method yields robust measures of emotionality across complementary tests for individual mice and experimental groups, hence facilitating the comparison across studies and refining the translational applicability of these models. Copyright © 2011 Elsevier B.V. All rights reserved.

The Problem of Defining Intelligence.

ERIC Educational Resources Information Center

Lubar, David

1981-01-01

The major philosophical issues surrounding the concept of intelligence are reviewed with respect to the problems surrounding the process of defining and developing artificial intelligence (AI) in computers. Various current definitions and problems with these definitions are presented. (MP)

Introduction to the special issue: Thermodynamic aspects of cryobiology.

PubMed

Elliott, Janet A W

2010-02-01

This brief paper introduces the subject of thermodynamics and the papers of the special issue on thermodynamic aspects of cryobiology. Thermodynamic terminology is defined for the non-specialist. Copyright 2009 Elsevier Inc. All rights reserved.

Type-II generalized family-wise error rate formulas with application to sample size determination.

PubMed

Delorme, Phillipe; de Micheaux, Pierre Lafaye; Liquet, Benoit; Riou, Jérémie

2016-07-20

Multiple endpoints are increasingly used in clinical trials. The significance of some of these clinical trials is established if at least r null hypotheses are rejected among m that are simultaneously tested. The usual approach in multiple hypothesis testing is to control the family-wise error rate, which is defined as the probability that at least one type-I error is made. More recently, the q-generalized family-wise error rate has been introduced to control the probability of making at least q false rejections. For procedures controlling this global type-I error rate, we define a type-II r-generalized family-wise error rate, which is directly related to the r-power defined as the probability of rejecting at least r false null hypotheses. We obtain very general power formulas that can be used to compute the sample size for single-step and step-wise procedures. These are implemented in our R package rPowerSampleSize available on the CRAN, making them directly available to end users. Complexities of the formulas are presented to gain insight into computation time issues. Comparison with Monte Carlo strategy is also presented. We compute sample sizes for two clinical trials involving multiple endpoints: one designed to investigate the effectiveness of a drug against acute heart failure and the other for the immunogenicity of a vaccine strategy against pneumococcus. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

MRD Testing in Multiple Myeloma: From a Surrogate Marker of Clinical Outcomes to an Every-Day Clinical Tool.

PubMed

Landgren, Ola

2018-01-01

Minimal residual disease (MRD) testing in multiple myeloma is here to stay. Studies show that MRD negativity is consistently associated with longer progression-free survival (PFS). It is just a matter of time until MRD negativity will become a regulatory endpoint for drug approval. Until that can happen, more analysis will be required to define the exact details of MRD in the regulatory setting. For example, for randomized studies there is need to define the amount of improvement in MRD negativity between the experimental arm and the control arm at a given time-point for a drug to obtain regulatory accelerated approval. Such efforts are underway. For the multiple myeloma field as a whole, important tasks for the (near) coming future are as follows: (1) to conduct or finalize the expanded analysis to define the exact details of MRD in the regulatory setting, (2) to develop new and better MRD assays-both more sensitive MRD assays for bone marrow aspirates and nonbone marrow aspirate-based assays (eg, blood-based and imaging-based MRD assays), and (3) to design novel clinical studies to formally assess the effect of MRD negativity in clinical decision making. The aim with this issue of the Journal is to provide a deep and comprehensive summary of the latest MRD knowledge in the field, and to outline future directions. Copyright © 2018 Elsevier Inc. All rights reserved.

Evaluation of a Community's Risk for Canine Parvovirus and Distemper Using Antibody Testing and GIS Mapping of Animal Shelter Intakes.

PubMed

Spindel, Miranda E; Krecic, Matthew R; Slater, Margaret R; Vigil, Nicole

2018-03-20

This cross-sectional study aimed to identify where dogs with negative antibody tests to canine parvovirus (CPV) and canine distemper virus (CDV) originated when entering a community shelter, using a commercially available ELISA antibody test and Geographic Information Systems mapping. Of 2745 canines entering during a three-month period, 1056 test results were obtained. Dogs or puppies weighing over 2 lb were eligible if they could be humanely, nonchemically restrained for phlebotomy. Age and minor health issues weren't exclusions. Dogs were excluded if trained personnel were concerned health would be compromised by phlebotomy. Blood samples were collected within 24 hours of entry. Four hundred and twenty-seven (40%) dogs had positive antibody test results for both viruses, 422 (40%) were positive for CPV, 37 (4%) were positive for CDV, and 170 (16%) were negative for both. Mapping revealed geographic patterns for dogs with negative antibody tests. This shelter admitted dogs with negative CPV and/or CDV antibody tests from defined community areas. Targeting vaccination efforts in communities to areas where dogs with negative antibody tests originate could be an effective wellness strategy.

Embryonic stem cells and the next generation of developmental toxicity testing.

PubMed

Kugler, Josephine; Huhse, Bettina; Tralau, Tewes; Luch, Andreas

2017-08-01

The advent of stem cell technology has seen the establishment of embryonic stem cells (ESCs) as molecular model systems and screening tools. Although ESCs are nowadays widely used in research, regulatory implementation for developmental toxicity testing is pending. Areas Covered: This review evaluates the performance of current ESC, including human (h)ESC testing systems, trying to elucidate their potential for developmental toxicity testing. It shall discuss defining parameters and mechanisms, their relevance and contemplate what can realistically be expected. Crucially this includes the question of how to ascertain the quality of currently employed cell lines and tests based thereon. Finally, the use of hESCs will raise ethical concerns which should be addressed early on. Expert Opinion: While the suitability of (h)ESCs as tools for research and development goes undisputed, any routine use for developmental toxicity testing currently still seems premature. The reasons for this comprise inherent biological deficiencies as well as cell line quality and system validation. Overcoming these issues will require collaboration of scientists, test developers and regulators. Also, validation needs to be made worthwhile for academia. Finally we have to continuously rethink existing strategies, making room for improved testing and innovative approaches.

Developing Information Systems for Competitive Intelligence Support.

ERIC Educational Resources Information Center

Hohhof, Bonnie

1994-01-01

Discusses issues connected with developing information systems for competitive intelligence support; defines the elements of an effective competitive information system; and summarizes issues affecting system design and implementation. Highlights include intelligence information; information needs; information sources; decision making; and…

miR-MaGiC improves quantification accuracy for small RNA-seq.

PubMed

Russell, Pamela H; Vestal, Brian; Shi, Wen; Rudra, Pratyaydipta D; Dowell, Robin; Radcliffe, Richard; Saba, Laura; Kechris, Katerina

2018-05-15

Many tools have been developed to profile microRNA (miRNA) expression from small RNA-seq data. These tools must contend with several issues: the small size of miRNAs, the small number of unique miRNAs, the fact that similar miRNAs can be transcribed from multiple loci, and the presence of miRNA isoforms known as isomiRs. Methods failing to address these issues can return misleading information. We propose a novel quantification method designed to address these concerns. We present miR-MaGiC, a novel miRNA quantification method, implemented as a cross-platform tool in Java. miR-MaGiC performs stringent mapping to a core region of each miRNA and defines a meaningful set of target miRNA sequences by collapsing the miRNA space to "functional groups". We hypothesize that these two features, mapping stringency and collapsing, provide more optimal quantification to a more meaningful unit (i.e., miRNA family). We test miR-MaGiC and several published methods on 210 small RNA-seq libraries, evaluating each method's ability to accurately reflect global miRNA expression profiles. We define accuracy as total counts close to the total number of input reads originating from miRNAs. We find that miR-MaGiC, which incorporates both stringency and collapsing, provides the most accurate counts.

A study on the utilization of advanced composites in commercial aircraft wing structure

NASA Technical Reports Server (NTRS)

Watts, D. J.

1978-01-01

A study was conducted to define the technology and data needed to support the introduction of advanced composite materials in the wing structure of future production aircraft. The study accomplished the following: (1) definition of acceptance factors, (2) identification of technology issues, (3) evaluation of six candidate wing structures, (4) evaluation of five program options, (5) definition of a composite wing technology development plan, (6) identification of full-scale tests, (7) estimation of program costs for the total development plan, (8) forecast of future utilization of composites in commercial transport aircraft and (9) identification of critical technologies for timely program planning.

A Multi-Agent Environment for Negotiation

NASA Astrophysics Data System (ADS)

Hindriks, Koen V.; Jonker, Catholijn M.; Tykhonov, Dmytro

In this chapter we introduce the System for Analysis of Multi-Issue Negotiation (SAMIN). SAMIN offers a negotiation environment that supports and facilitates the setup of various negotiation setups. The environment has been designed to analyse negotiation processes between human negotiators, between human and software agents, and between software agents. It offers a range of different agents, different domains, and other options useful to define a negotiation setup. The environment has been used to test and evaluate a range of negotiation strategies in various domains playing against other negotiating agents as well as humans. We discuss some of the results obtained by means of these experiments.

Extending software repository hosting to code review and testing

NASA Astrophysics Data System (ADS)

Gonzalez Alvarez, A.; Aparicio Cotarelo, B.; Lossent, A.; Andersen, T.; Trzcinska, A.; Asbury, D.; Hłimyr, N.; Meinhard, H.

2015-12-01

We will describe how CERN's services around Issue Tracking and Version Control have evolved, and what the plans for the future are. We will describe the services main design, integration and structure, giving special attention to the new requirements from the community of users in terms of collaboration and integration tools and how we address this challenge when defining new services based on GitLab for collaboration to replace our current Gitolite service and Code Review and Jenkins for Continuous Integration. These new services complement the existing ones to create a new global "development tool stack" where each working group can place its particular development work-flow.

Moral reasoning and personality traits.

PubMed

Mudrack, Peter E

2006-06-01

Moral reasoning should not be clearly associated with measures of personality traits. Although this assumption pervades the moral reasoning literature, it may not always be true. This paper provides evidence that moral reasoning, as assessed with P scores of the Defining Issues Test, is indeed positively associated with five traits from the California Psychological Inventory: Achievement via Independence, Intellectual Efficiency, Tolerance, Responsibility, and Capacity for Status. Such relationships make conceptual sense, shed light on the meaning and implications of moral reasoning, call into question prevailing assumptions in the literature, and may encourage investigators to broaden the types of research questions asked in the context of moral reasoning.

Investigation of Concrete Floor Vibration Using Heel-Drop Test

NASA Astrophysics Data System (ADS)

Azaman, N. A. Mohd; Ghafar, N. H. Abd; Azhar, A. F.; Fauzi, A. A.; Ismail, H. A.; Syed Idrus, S. S.; Mokhjar, S. S.; Hamid, F. F. Abd

2018-04-01

In recent years, there is an increased in floor vibration problems of structures like residential and commercial building. Vibration is defined as a serviceability issue related to the comfort of the occupant or damage equipment. Human activities are the main source of vibration in the building and it could affect the human comfort and annoyance of residents in the building when the vibration exceed the recommend level. A new building, Madrasah Tahfiz located at Yong Peng have vibration problem when load subjected on the first floor of the building. However, the limitation of vibration occurs on building is unknown. Therefore, testing is needed to determine the vibration behaviour (frequency, damping ratio and mode shape) of the building. Heel-drop with pace 2Hz was used in field measurement to obtain the vibration response. Since, the heel-drop test results would vary in light of person performance, test are carried out three time to reduce uncertainty. Natural frequency from Frequency Response Function analysis (FRF) is 17.4Hz, 16.8, 17.4Hz respectively for each test.

21 CFR 184.1271 - L-Cysteine.

Code of Federal Regulations, 2014 CFR

2014-04-01

... dough as a dough strengthener as defined in § 170.3(o)(6) of this chapter in yeast-leavened baked goods and baking mixes as defined in § 170.3(n)(1) of this chapter. (d) This regulation is issued prior to a...

48 CFR 50.201 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... requirements or such other requirements as defined and specified by the Secretary of Homeland Security: (1) Is... otherwise cause, for which a SAFETY Act designation has been issued. For purposes of defining a QATT..., engineering services, software development services, software integration services, threat assessments...

48 CFR 50.201 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... requirements or such other requirements as defined and specified by the Secretary of Homeland Security: (1) Is... otherwise cause, for which a SAFETY Act designation has been issued. For purposes of defining a QATT..., engineering services, software development services, software integration services, threat assessments...

48 CFR 50.201 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... requirements or such other requirements as defined and specified by the Secretary of Homeland Security: (1) Is... otherwise cause, for which a SAFETY Act designation has been issued. For purposes of defining a QATT..., engineering services, software development services, software integration services, threat assessments...

48 CFR 50.201 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... requirements or such other requirements as defined and specified by the Secretary of Homeland Security: (1) Is... otherwise cause, for which a SAFETY Act designation has been issued. For purposes of defining a QATT..., engineering services, software development services, software integration services, threat assessments...

48 CFR 50.201 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... requirements or such other requirements as defined and specified by the Secretary of Homeland Security: (1) Is... otherwise cause, for which a SAFETY Act designation has been issued. For purposes of defining a QATT..., engineering services, software development services, software integration services, threat assessments...

INTEGRATING PROBABILISTIC AND FIXED-SITE MONITORING FOR ROBUST WATER QUALITY ASSESSMENTS

EPA Science Inventory

Determining the extent of water-quality degradation, controlling nonpoint sources, and defining allowable amounts of contaminants are important water-quality issues defined in the Clean Water Act that require new monitoring data. Probabilistic, randomized stream water-quality mon...

Preliminary testing of a just‐in‐time, user‐defined values clarification exercise to aid lower literate women in making informed breast cancer treatment decisions

PubMed Central

Jibaja‐Weiss, Maria L.; Volk, Robert J.; Friedman, Lois C.; Granchi, Thomas S.; Neff, Nancy E.; Spann, Stephen J.; Robinson, Emily K.; Aoki, Noriaki; Robert Beck, J.

2006-01-01

Abstract Objective  To report on the initial testing of a values clarification exercise utilizing a jewellery box within a computerized patient decision aid (CPtDA) designed to assist women in making a surgical breast cancer treatment decision. Design  Pre‐post design, with patients interviewed after diagnosis, and then after completing the CPtDA sometime later at their preoperative visit. Sample  Fifty‐one female patients, who are low literate and naïve computer users, newly diagnosed with early stage breast cancer from two urban public hospitals. Intervention  A computerized decision aid that combines entertainment‐education (edutainment) with enhanced (factual) content. An interactive jewellery box is featured to assist women in: (1) recording and reflecting over issues of concern with possible treatments, (2) deliberating over surgery decision, and (3) communicating with physician and significant others. Outcomes  Patients’ use of the jewellery box to store issues during completion of the CPtDA, and perceived clarity of values in making a treatment decision, as measured by a low literacy version of the Decisional Conflict Scale (DCS). Results  Over half of the participants utilized the jewellery box to store issues they found concerning about the treatments. On average, users flagged over 13 issues of concern with the treatments. Scores on the DCS Uncertainty and Feeling Unclear about Values subscales were lower after the intervention compared to before the decision was made. Conclusions  A values clarification exercise using an interactive jewellery box may be a promising method for promoting informed treatment decision making by low literacy breast cancer patients. PMID:16911136

How the Government Defines "Rural" Has Implications for Education Policies and Practices. Issues & Answers. REL 2007-010

ERIC Educational Resources Information Center

Arnold, Michael L.; Biscoe, Belinda; Farmer, Thomas W.; Robertson, Dylan L.; Shapley, Kathy L.

2007-01-01

Clearly defining what rural means has tangible implications for public policies and practices in education, from establishing resource needs to achieving the goals of No Child Left Behind in rural areas. The word "rural" has many meanings. It has been defined in reference to population density, geographic features, and level of economic…

Assistive Technology: Issues and Trends.

ERIC Educational Resources Information Center

Scherer, Marcia J.

This paper discusses current issues regarding assistive technology devices and services, especially in relation to the roles and responsibilities of the rehabilitation psychologist. Following an introductory section which defines an assistive technology device and an assistive technology service, the following sections discuss: (1) past…

OECD Trilog Plenary Symposium : public policy issues in global freight logistics

DOT National Transportation Integrated Search

1995-01-01

In this study, the authors present a qualitative assessment of the potential effects of various ITS strategies on pollutant emission from motor vehicles. They first provide an overview of the major issues defining the possible relationships between I...

Post-approval safety issues with innovative drugs: a European cohort study.

PubMed

Mol, Peter G M; Arnardottir, Arna H; Motola, Domenico; Vrijlandt, Patrick J; Duijnhoven, Ruben G; Haaijer-Ruskamp, Flora M; de Graeff, Pieter A; Denig, Petra; Straus, Sabine M J M

2013-11-01

At time of approval, knowledge of the full benefit risk of any drug is limited, in particular with regards to safety. Post-approval surveillance of potential drug safety concerns is recognized as an important task of regulatory agencies. For innovative, often first-in-class drugs, safety knowledge at time of approval is often even less extensive and these may require tighter scrutiny post approval. We evaluated whether more post-approval serious safety issues were identified for drugs with a higher level of innovation. A cohort study was performed that included all new active substances approved under the European Centralized Procedure and for which serious safety issues were identified post-approval from 1 January 1999 to 1 January 2012. Serious safety issues were defined as issues requiring a Direct Healthcare Professional Communication to alert individual healthcare professionals of a new serious safety issue, or a safety-related drug withdrawal. Data were retrieved from publicly available websites of the Dutch Medicines Evaluation Board and the European Medicines Agency. The level of innovation was scored using a validated algorithm, grading drugs as important (A), moderate (B) or modest (C) innovations or as pharmacological or technological (pharm/tech) innovations. The data were analyzed using appropriate descriptive statistics and Kaplan-Meier analysis, with a Mantel-Cox log-rank test, and Cox-regression models correcting for follow-up duration, to identify a possible trend in serious safety issues with an increasing level of innovation. In Europe, 279 new drugs were approved between 1999 and 2011. Fifty-nine (21 %) were graded as important, 63 (23 %) moderate, or 34 (12 %) modest innovations and 123 (44 %) as non-innovative (pharm/tech), while 15 (25 %), 13 (21 %), 8 (24 %) and 17 (14 %) had post-approval safety issues, respectively (p = 0.06, linear-by-linear test). Five drugs were withdrawn from the market. The Kaplan-Meier-derived probability for having a first serious safety issue was statistically significant, log-rank (Mantel-Cox) p = 0.036. In the final adjusted Cox proportional hazard model there was no statistically significant difference in occurrence of a first serious safety issue for important, moderate and modest innovations versus non-innovative drugs; hazard ratios 1.76 (95 % CI 0.82-3.77), 1.61 (95 % CI 0.76-3.41)], and 1.25 (95 % CI 0.51-3.06), respectively. A higher level of innovation was not clearly related to an increased risk of serious safety issues identified after approval.

Quality by design for herbal drugs: a feedforward control strategy and an approach to define the acceptable ranges of critical quality attributes.

PubMed

Yan, Binjun; Li, Yao; Guo, Zhengtai; Qu, Haibin

2014-01-01

The concept of quality by design (QbD) has been widely accepted and applied in the pharmaceutical manufacturing industry. There are still two key issues to be addressed in the implementation of QbD for herbal drugs. The first issue is the quality variation of herbal raw materials and the second issue is the difficulty in defining the acceptable ranges of critical quality attributes (CQAs). To propose a feedforward control strategy and a method for defining the acceptable ranges of CQAs for the two issues. In the case study of the ethanol precipitation process of Danshen (Radix Salvia miltiorrhiza) injection, regression models linking input material attributes and process parameters to CQAs were built first and an optimisation model for calculating the best process parameters according to the input materials was established. Then, the feasible material space was defined and the acceptable ranges of CQAs for the previous process were determined. In the case study, satisfactory regression models were built with cross-validated regression coefficients (Q(2) ) all above 91 %. The feedforward control strategy was applied successfully to compensate the quality variation of the input materials, which was able to control the CQAs in the 90-110 % ranges of the desired values. In addition, the feasible material space for the ethanol precipitation process was built successfully, which showed the acceptable ranges of the CQAs for the concentration process. The proposed methodology can help to promote the implementation of QbD for herbal drugs. Copyright © 2013 John Wiley & Sons, Ltd.

Measuring Graduation and Attrition at Ontario Colleges: A Discussion of Measurement Issues and Their Usefulness as Indicators of Student Success.

ERIC Educational Resources Information Center

Donner, Arthur; Lazar, Fred

This report discusses measurement issues and their usefulness as indicators of student success at the Colleges of Applied Arts and Technology of Ontario. The following sections are included: (1) executive summary; (2) introduction; (3) retention rates, which discusses a number of issues associated with defining and measuring graduation rates; (4)…

Consumer Education: It's a Basic.

ERIC Educational Resources Information Center

NASSP Curriculum Report, 1980

1980-01-01

The report discusses and defines consumer education for high school students, describes various consumer education school programs, annotates available sources and resources, and notes several issues needing attention. Consumer education is defined as an effort to prepare students for participation in the marketplace by imparting the…

Body Mass Index

PubMed Central

Nuttall, Frank Q.

2015-01-01

The body mass index (BMI) is the metric currently in use for defining anthropometric height/weight characteristics in adults and for classifying (categorizing) them into groups. The common interpretation is that it represents an index of an individual’s fatness. It also is widely used as a risk factor for the development of or the prevalence of several health issues. In addition, it is widely used in determining public health policies.The BMI has been useful in population-based studies by virtue of its wide acceptance in defining specific categories of body mass as a health issue. However, it is increasingly clear that BMI is a rather poor indicator of percent of body fat. Importantly, the BMI also does not capture information on the mass of fat in different body sites. The latter is related not only to untoward health issues but to social issues as well. Lastly, current evidence indicates there is a wide range of BMIs over which mortality risk is modest, and this is age related. All of these issues are discussed in this brief review. PMID:27340299

Designs and Algorithms to Map Eye Tracking Data with Dynamic Multielement Moving Objects.

PubMed

Kang, Ziho; Mandal, Saptarshi; Crutchfield, Jerry; Millan, Angel; McClung, Sarah N

2016-01-01

Design concepts and algorithms were developed to address the eye tracking analysis issues that arise when (1) participants interrogate dynamic multielement objects that can overlap on the display and (2) visual angle error of the eye trackers is incapable of providing exact eye fixation coordinates. These issues were addressed by (1) developing dynamic areas of interests (AOIs) in the form of either convex or rectangular shapes to represent the moving and shape-changing multielement objects, (2) introducing the concept of AOI gap tolerance (AGT) that controls the size of the AOIs to address the overlapping and visual angle error issues, and (3) finding a near optimal AGT value. The approach was tested in the context of air traffic control (ATC) operations where air traffic controller specialists (ATCSs) interrogated multiple moving aircraft on a radar display to detect and control the aircraft for the purpose of maintaining safe and expeditious air transportation. In addition, we show how eye tracking analysis results can differ based on how we define dynamic AOIs to determine eye fixations on moving objects. The results serve as a framework to more accurately analyze eye tracking data and to better support the analysis of human performance.

Designs and Algorithms to Map Eye Tracking Data with Dynamic Multielement Moving Objects

PubMed Central

Mandal, Saptarshi

2016-01-01

Design concepts and algorithms were developed to address the eye tracking analysis issues that arise when (1) participants interrogate dynamic multielement objects that can overlap on the display and (2) visual angle error of the eye trackers is incapable of providing exact eye fixation coordinates. These issues were addressed by (1) developing dynamic areas of interests (AOIs) in the form of either convex or rectangular shapes to represent the moving and shape-changing multielement objects, (2) introducing the concept of AOI gap tolerance (AGT) that controls the size of the AOIs to address the overlapping and visual angle error issues, and (3) finding a near optimal AGT value. The approach was tested in the context of air traffic control (ATC) operations where air traffic controller specialists (ATCSs) interrogated multiple moving aircraft on a radar display to detect and control the aircraft for the purpose of maintaining safe and expeditious air transportation. In addition, we show how eye tracking analysis results can differ based on how we define dynamic AOIs to determine eye fixations on moving objects. The results serve as a framework to more accurately analyze eye tracking data and to better support the analysis of human performance. PMID:27725830

Neural correlates of post-conventional moral reasoning: a voxel-based morphometry study.

PubMed

Prehn, Kristin; Korczykowski, Marc; Rao, Hengyi; Fang, Zhuo; Detre, John A; Robertson, Diana C

2015-01-01

Going back to Kohlberg, moral development research affirms that people progress through different stages of moral reasoning as cognitive abilities mature. Individuals at a lower level of moral reasoning judge moral issues mainly based on self-interest (personal interests schema) or based on adherence to laws and rules (maintaining norms schema), whereas individuals at the post-conventional level judge moral issues based on deeper principles and shared ideals. However, the extent to which moral development is reflected in structural brain architecture remains unknown. To investigate this question, we used voxel-based morphometry and examined the brain structure in a sample of 67 Master of Business Administration (MBA) students. Subjects completed the Defining Issues Test (DIT-2) which measures moral development in terms of cognitive schema preference. Results demonstrate that subjects at the post-conventional level of moral reasoning were characterized by increased gray matter volume in the ventromedial prefrontal cortex and subgenual anterior cingulate cortex, compared with subjects at a lower level of moral reasoning. Our findings support an important role for both cognitive and emotional processes in moral reasoning and provide first evidence for individual differences in brain structure according to the stages of moral reasoning first proposed by Kohlberg decades ago.

The Environmental Protection Agency's Community-Focused Exposure and Risk Screening Tool (C-FERST) and its potential use for environmental justice efforts.

PubMed

Zartarian, Valerie G; Schultz, Bradley D; Barzyk, Timothy M; Smuts, Marybeth; Hammond, Davyda M; Medina-Vera, Myriam; Geller, Andrew M

2011-12-01

Our primary objective was to provide higher quality, more accessible science to address challenges of characterizing local-scale exposures and risks for enhanced community-based assessments and environmental decision-making. After identifying community needs, priority environmental issues, and current tools, we designed and populated the Community-Focused Exposure and Risk Screening Tool (C-FERST) in collaboration with stakeholders, following a set of defined principles, and considered it in the context of environmental justice. C-FERST is a geographic information system and resource access Web tool under development for supporting multimedia community assessments. Community-level exposure and risk research is being conducted to address specific local issues through case studies. C-FERST can be applied to support environmental justice efforts. It incorporates research to develop community-level data and modeled estimates for priority environmental issues, and other relevant information identified by communities. Initial case studies are under way to refine and test the tool to expand its applicability and transferability. Opportunities exist for scientists to address the many research needs in characterizing local cumulative exposures and risks and for community partners to apply and refine C-FERST.

Tank 241-AZ-102 Privatization Push Mode Core Sampling and Analysis Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

RASMUSSEN, J.H.

1999-08-02

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AZ-102. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AZ-102 required to satisfy the Data Quality Objectives For TWRS Privatization Phase I: Confirm Tank TIS An Appropriate Feed Source For High-Level Waste Feed Batch X(HLW DQO) (Nguyen 1999a), Data Quality Objectives For TWRS Privatization Phase 1: Confirm Tank TIS An Appropriate Feed Source For Low-Activity Waste Feed Batch X (LAW DQO) (Nguyen 1999b), Low Activity Waste andmore » High Level Waste Feed Data Quality Objectives (L&H DQO) (Patello et al. 1999) and Characterization Data Needs for Development, Design, and Operation of Retrieval Equipment Developed through the Data Quality Objective Process (Equipment DQO) (Bloom 1996). The Tank Characterization Technical Sampling Basis document (Brown et al. 1998) indicates that these issues, except the Equipment DQO apply to tank 241-AZ-102 for this sampling event. The Equipment DQO is applied for shear strength measurements of the solids segments only. Poppiti (1999) requires additional americium-241 analyses of the sludge segments. Brown et al. (1998) also identify safety screening, regulatory issues and provision of samples to the Privatization Contractor(s) as applicable issues for this tank. However, these issues will not be addressed via this sampling event. Reynolds et al. (1999) concluded that information from previous sampling events was sufficient to satisfy the safety screening requirements for tank 241 -AZ-102. Push mode core samples will be obtained from risers 15C and 24A to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives. The 222-S Laboratory will extrude core samples, composite the liquids and solids, perform chemical analyses, and provide subsamples to the Process Chemistry Laboratory. The Process Chemistry Laboratory will prepare test plans and perform process tests to evaluate the behavior of the 241-AZ-102 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. Requirements for analyses of samples originating in the process tests will be documented in the corresponding test plan.« less

Plans, Trains, and Automobiles: Big River Crossing Issues in a Small Community

DOT National Transportation Integrated Search

1999-01-01

This paper addresses cross-cutting topics associated with the replacement of a : regional Mississippi River crossing along the Great River Road. The breadth and : depth of issues define the ease with which transportation problems can be solved. : In ...

Wanted: Good Leaders for Urban Schools

ERIC Educational Resources Information Center

Durden, Phyllis C.

2008-01-01

Differences in values and socio-economics, issues of diversity and equity, and changing educational expectations and structures challenge leadership preparation programs, particularly those in urban environments. This article focuses on discerning major urban education issues, defining constructs of leadership for urban schools, and identifying a…

A Re-Examination of Educational Issues.

ERIC Educational Resources Information Center

Kitano, Margie

This paper suggests how an anthropological perspective can help educators rethink important educational issues, including multicultural education, leadership training, and educational processes. Opening sections of the paper define anthropology (the study of human beings and their ways of life), and identify anthropological concepts and principles…

Health Related Legal Issues in Education.

ERIC Educational Resources Information Center

Thomas, Stephen B.

This monograph analyzes health and safety issues in education in terms of relevant constitutional and statutory provisions. Chapter 1, an introduction, summarizes Fourteenth Amendment equal protection and due process clauses and defines "handicapped" under the Rehabilitation Act. State assistance and student eligibility under the…

Review of the institutional issues relating to road weather information systems (RWIS)

DOT National Transportation Integrated Search

1998-08-01

This project, funded by the Aurora Program, aimed to identify and document institutional issues relating to the implementation and development of Road Weather Information Systems (RWIS). For the purposes of this study, RWIS can be briefly defined as ...

The Molecular and Cellular Basis of Bitter Taste in Drosophila

PubMed Central

Weiss, Linnea A.; Dahanukar, Anupama; Kwon, Jae Young; Banerjee, Diya; Carlson, John R.

2011-01-01

Summary The extent of diversity among bitter-sensing neurons is a fundamental issue in the field of taste. Data are limited and conflicting as to whether bitter neurons are broadly tuned and uniform, resulting in indiscriminate avoidance of bitter stimuli, or diverse, allowing a more discerning evaluation of food sources. We provide a systematic analysis of how bitter taste is encoded by the major taste organ of the Drosophila head, the labellum. Each of 16 bitter compounds is tested physiologically against all 31 bitter neurons, revealing responses that are diverse in magnitude and dynamics. Four functional classes of bitter neurons are defined. Four corresponding classes are defined through expression analysis of all 68 Gr taste receptors. A receptor-to-neuron-to-tastant map is constructed. Misexpression of one receptor confers bitter responses as predicted by the map. These results reveal a degree of complexity that greatly expands the capacity of the system to encode bitter taste. PMID:21262465

Acoustic Features Influence Musical Choices Across Multiple Genres.

PubMed

Barone, Michael D; Bansal, Jotthi; Woolhouse, Matthew H

2017-01-01

Based on a large behavioral dataset of music downloads, two analyses investigate whether the acoustic features of listeners' preferred musical genres influence their choice of tracks within non-preferred, secondary musical styles. Analysis 1 identifies feature distributions for pairs of genre-defined subgroups that are distinct. Using correlation analysis, these distributions are used to test the degree of similarity between subgroups' main genres and the other music within their download collections. Analysis 2 explores the issue of main-to-secondary genre influence through the production of 10 feature-influence matrices, one per acoustic feature, in which cell values indicate the percentage change in features for genres and subgroups compared to overall population averages. In total, 10 acoustic features and 10 genre-defined subgroups are explored within the two analyses. Results strongly indicate that the acoustic features of people's main genres influence the tracks they download within non-preferred, secondary musical styles. The nature of this influence and its possible actuating mechanisms are discussed with respect to research on musical preference, personality, and statistical learning.

Did You Remember to DID

DTIC Science & Technology

2010-04-01

threats (also known as a SWOT analysis) is a very useful method in identifying potential issues, hidden agendas, and competing egos. • Defining a...comprehensive communications plan uses what’s been defined and informs (the second key component to DID) government and con - tractor teams of the essential...program execution strategies. Inform Inform means communicating to internal and external stake- holders what was defined, expected, discovered, con

Ethics of human testing.

PubMed

Salter, D C

1990-08-01

What should one do, and why? Anyone asking such questions--and everyone does so hundreds of time each day--is concerned with ethics. Product development and testing raise many ethical questions. Particularly since the rise of 'green consumerism', these are of increasing concern to people outside the cosmetics industry, and so should be of interest to those inside it. The major problem seems to be that of reaching agreement on moral and ethical issues. Overcoming this problem involves investigating what is meant by 'ethics', and how decisions depend not on facts but on 'facts-as-perceived'. These in turn depend on many factors, with one's philosophy being the most fundamental. The range of philosophical options is reviewed and it is proposed that wider discussion is the only just way to achieve agreement. Yet some things are not negotiable. There are certain key moral concepts in terms of which discussion must take place for it to be relevant. In ethics of human testing, 'respect for others', that is, avoiding exploitation, is the principal one. Some synthesis of the key moral concepts like that of Immanuel Kant is therefore recommended as the soundest and most widely acceptable basis for the necessary discussion. Defining the responsible use of human subjects covers a range of issues, moral, historical, legal and professional. For example, there may be ethical difficulties in deliberate damage induction as in SPF and irritancy testing. But above all, to avoid exploitation, there is a moral and also a legal requirement that subjects are truly volunteers. This is the basis of the concept of 'informed consent', required but not generally explained in current professional codes of practice. It is unjustified to exploit those who may be under duress, such as 'in-house volunteers' and those with low incomes. Hence in conclusion, criteria for obtaining valid informed consent are briefly reviewed. By considering issues such as these, we can help ensure that cosmetic scientists are true professionals, that is, those who recognise and are concerned with the ethical basis of their work.

Defining and Building an Enriched Learning and Information Environment.

ERIC Educational Resources Information Center

Goodrum, David A.; And Others

1993-01-01

Discusses the development of an Enriched Learning and Information Environment (ELIE). Highlights include technology-based and theory-based frameworks for defining ELIEs; a socio-technical definition; a conceptual prototype; a participatory design process, including iterative design through rapid prototyping; and design issues for technology…

Educating Exceptional Children: Current Issue for Educators

ERIC Educational Resources Information Center

Specht, Jacqueline

2004-01-01

The Oxford dictionary defines exceptionality as "forming an exception; very unusual; outstandingly good." A thesaurus provides the following synonyms: outstanding, excellent, brilliant, antonym of ordinary. In education and psychology textbooks and journals, however, it is often defined in ways that focus on limitations, with synonyms…

Defined by Limitations

ERIC Educational Resources Information Center

Arriola, Sonya; Murphy, Katy

2010-01-01

Undocumented students are a population defined by limitations. Their lack of legal residency and any supporting paperwork (e.g., Social Security number, government issued identification) renders them essentially invisible to the American and state governments. They cannot legally work. In many states, they cannot legally drive. After the age of…

Resiliency of the Multiscale Retinex Image Enhancement Algorithm

NASA Technical Reports Server (NTRS)

Rahman, Zia-Ur; Jobson, Daniel J.; Woodell, Glenn A.

1998-01-01

The multiscale retinex with color restoration (MSRCR) continues to prove itself in extensive testing to be very versatile automatic image enhancement algorithm that simultaneously provides dynamic range compression, color constancy, and color rendition, However, issues remain with regard to the resiliency of the MSRCR to different image sources and arbitrary image manipulations which may have been applied prior to retinex processing. In this paper we define these areas of concern, provide experimental results, and, examine the effects of commonly occurring image manipulation on retinex performance. In virtually all cases the MSRCR is highly resilient to the effects of both the image source variations and commonly encountered prior image-processing. Significant artifacts are primarily observed for the case of selective color channel clipping in large dark zones in a image. These issues are of concerning the processing of digital image archives and other applications where there is neither control over the image acquisition process, nor knowledge about any processing done on th data beforehand.

Guidelines for the identification of unknown samples for laboratories performing forensic analyses for chemical terrorism.

PubMed

Magnuson, Matthew L; Satzger, R Duane; Alcaraz, Armando; Brewer, Jason; Fetterolf, Dean; Harper, Martin; Hrynchuk, Ronald; McNally, Mary F; Montgomery, Madeline; Nottingham, Eric; Peterson, James; Rickenbach, Michael; Seidel, Jimmy L; Wolnik, Karen

2012-05-01

Since the early 1990s, the FBI Laboratory has sponsored Scientific Working Groups to improve discipline practices and build consensus among the forensic community. The Scientific Working Group on the Forensic Analysis of Chemical, Biological, Radiological and Nuclear Terrorism developed guidance, contained in this document, on issues forensic laboratories encounter when accepting and analyzing unknown samples associated with chemical terrorism, including laboratory capabilities and analytical testing plans. In the context of forensic analysis of chemical terrorism, this guidance defines an unknown sample and addresses what constitutes definitive and tentative identification. Laboratory safety, reporting issues, and postreporting considerations are also discussed. Utilization of these guidelines, as part of planning for forensic analysis related to a chemical terrorism incident, may help avoid unfortunate consequences not only to the public but also to the laboratory personnel. 2011 American Academy of Forensic Sciences. Published 2011. This article is a U.S. Government work and is in the public domain in the U.S.A.

Establishing bioequivalence of veterinary premixes (Type A medicated articles).

PubMed

Hunter, R P; Lees, P; Concordet, D; Toutain, P-L

2012-04-01

a) Key issues concerning Premix (Type A medicated articles) Bioequivalence evaluations: 1) This is a complex issue concerning both route of administration and formulation. 2) If the animal is not at the bunk/trough, the animal is not self-administering (eating medicated feed), thus there can be no drug absorption. b) Differing opinions among scientists and regulatory authorities/expert bodies regarding: 1) No harmonization on how to design, conduct, and interpret in vivo studies. 2) Applicability of biowaivers to Type A (premix) products. 3) Why are topdress and complete feed considered differently? Are they different formulations or different routes of administration? 4) Single dose vs. multi-dose studies. 5) What is the final formulation? c) What are the next steps: 1) Harmonize current bioequivalence guidelines through the VICH process. 2) Determine the applicability/non-applicability of the Biopharmaceutical Classification System (BCS). 3) Establish the Total Mixed Ration (i.e. formulation) effects. 4) Define the test subject (individual, pen, etc.). © 2012 Blackwell Publishing Ltd.

Initial research on the characterization methods of sparkle spots in optical thin films

NASA Astrophysics Data System (ADS)

Jiang, Jinhu; Gu, Wenhua

2018-01-01

In this article, we made a preliminary study on the main influencing factors of sparkle spots, put forward the concept of "sparklingness" to characterize the strength of sparkle spots, and proposed a standard measurement method for the sparklingness. We proposed to use 532 nm green laser pointer as the testing light source, let the light pass through the film and form a sparkle spots image at the receiving CCD or a piece of white paper. A standard image processing method was used to obtain an index number standing for the scattering status of the laser, which is defined as "sparklingness". In the experiment, we also analyzed the power dependence of sparklingness. With proper calibration, the measurement error of the sparklingness can be minimized, and it can be used as a physical quantity to describe the film quality as of the sparkle issue. This work can be a useful reference for further study of the sparkle issue in optical films.

Image-guided intervention in the coagulopathic patient.

PubMed

Kohli, Marc; Mayo-Smith, William; Zagoria, Ronald; Sandrasegaran, Kumar

2016-04-01

Determining practice parameters for interventional procedures is challenging due to many factors including unreliable laboratory tests to measure bleeding risk, variable usage of standardized terminology for adverse events, poorly defined standards for administration of blood products, and the growing numbers of anticoagulant and antiplatelet medications. We aim to address these and other issues faced by radiologists performing invasive procedures through a review of available literature, and experiential guidance from three academic medical centers. We discuss the significant limitations with respect to using prothrombin-time and international normalized ratio to measure bleeding risk, especially in patients with synthetic defects due to liver function. Factors affecting platelet function including the impact of uremia; recent advances in laboratory testing, including platelet function testing; and thromboelastography are also discussed. A review of the existing literature of fresh-frozen plasma replacement therapy is included. The literature regarding comorbidities affecting coagulation including malignancy, liver failure, and uremia are also reviewed. Finally, the authors present a set of recommendations for laboratory thresholds, corrective transfusions, as well as withholding and restarting medications.

Computer Software & Intellectual Property. Background Paper.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Office of Technology Assessment.

This background paper reviews copyright, patent, and trade secret protections as these issues are related to computer software. Topics discussed include current issues regarding legal protection for computer software including the necessity for defining intellectual property, determining what should or should not be protected, commerical piracy,…

The Struggle with Hate Speech. Teaching Strategy.

ERIC Educational Resources Information Center

Bloom, Jennifer

1995-01-01

Discusses the issue of hate-motivated violence and special laws aimed at deterrence. Presents a secondary school lesson to help students define hate speech and understand constitutional issues related to the topic. Includes three student handouts, student learning objectives, instructional procedures, and a discussion guide. (CFR)

Policy.

ERIC Educational Resources Information Center

Evans, Judith L.; And Others

1995-01-01

This theme issue is devoted to discussions of early childhood policy issues. "Creating a Shared Vision: How Policy Affects Early Childhood Care and Development" (Judith L. Evans) defines policy, discusses the motivation for changing or creating national policy and the process for changing such policies, and provides a sample design for…

Rethinking Productivity from a Workplace Perspective. CPRN Discussion Paper.

ERIC Educational Resources Information Center

Gunderson, Morley

The issue of increasing productivity was examined from an interdisciplinary perspective focusing on the impact of workplace practices on various productivity-related outcomes. First, the following methodological issues were discussed: defining workplace practices that affect productivity; linking employer behavior and organizational performance;…

Instructional Applications of Hypermedia: Functional Features, Limitations, and Research Issues.

ERIC Educational Resources Information Center

Park, Ok-choon

1992-01-01

Defines hypermedia and describes the structure and functional requirements of a hypermedia program. Potentials of hypermedia for instructional delivery, idea generation and organization, file storage and organization, and development of computer-based instruction materials are discussed. Several research issues related to instructional…

GMOtrack: generator of cost-effective GMO testing strategies.

PubMed

Novak, Petra Krau; Gruden, Kristina; Morisset, Dany; Lavrac, Nada; Stebih, Dejan; Rotter, Ana; Zel, Jana

2009-01-01

Commercialization of numerous genetically modified organisms (GMOs) has already been approved worldwide, and several additional GMOs are in the approval process. Many countries have adopted legislation to deal with GMO-related issues such as food safety, environmental concerns, and consumers' right of choice, making GMO traceability a necessity. The growing extent of GMO testing makes it important to study optimal GMO detection and identification strategies. This paper formally defines the problem of routine laboratory-level GMO tracking as a cost optimization problem, thus proposing a shift from "the same strategy for all samples" to "sample-centered GMO testing strategies." An algorithm (GMOtrack) for finding optimal two-phase (screening-identification) testing strategies is proposed. The advantages of cost optimization with increasing GMO presence on the market are demonstrated, showing that optimization approaches to analytic GMO traceability can result in major cost reductions. The optimal testing strategies are laboratory-dependent, as the costs depend on prior probabilities of local GMO presence, which are exemplified on food and feed samples. The proposed GMOtrack approach, publicly available under the terms of the General Public License, can be extended to other domains where complex testing is involved, such as safety and quality assurance in the food supply chain.

Voices, Places and Conversations about Service Learning: Making Connections.

ERIC Educational Resources Information Center

Oliver, Helen T.

This paper defines service-learning by college students in the context of institutional purpose, mission, and curriculum while simultaneously defining community and echoing conversations about student service-learning experiences. These issues include: (1) voices--institutional purpose and mission and founding principles; (2) places--the student,…

Defining the Language Arts.

ERIC Educational Resources Information Center

Barth, Patte, Ed.

1994-01-01

This issue of "Basic Education" presents articles that discuss, respectively, defining the language arts, an agenda for English, the benefits of two languages, a new teacher (presently teaching English in a foreign country) looking ahead, and the Shaker Fellowships awarded by the school district in Shaker Heights, Ohio. Articles in the…

A finite element method for solving the shallow water equations on the sphere

NASA Astrophysics Data System (ADS)

Comblen, Richard; Legrand, Sébastien; Deleersnijder, Eric; Legat, Vincent

Within the framework of ocean general circulation modeling, the present paper describes an efficient way to discretize partial differential equations on curved surfaces by means of the finite element method on triangular meshes. Our approach benefits from the inherent flexibility of the finite element method. The key idea consists in a dialog between a local coordinate system defined for each element in which integration takes place, and a nodal coordinate system in which all local contributions related to a vectorial degree of freedom are assembled. Since each element of the mesh and each degree of freedom are treated in the same way, the so-called pole singularity issue is fully circumvented. Applied to the shallow water equations expressed in primitive variables, this new approach has been validated against the standard test set defined by [Williamson, D.L., Drake, J.B., Hack, J.J., Jakob, R., Swarztrauber, P.N., 1992. A standard test set for numerical approximations to the shallow water equations in spherical geometry. Journal of Computational Physics 102, 211-224]. Optimal rates of convergence for the P1NC-P1 finite element pair are obtained, for both global and local quantities of interest. Finally, the approach can be extended to three-dimensional thin-layer flows in a straightforward manner.

Standardized Tests as Outcome Measures for Evaluating Instructional Interventions in Mathematics and Science

NASA Astrophysics Data System (ADS)

Sussman, Joshua Michael

This three-paper dissertation explores problems with the use of standardized tests as outcome measures for the evaluation of instructional interventions in mathematics and science. Investigators commonly use students' scores on standardized tests to evaluate the impact of instructional programs designed to improve student achievement. However, evidence suggests that the standardized tests may not measure, or may not measure well, the student learning caused by the interventions. This problem is special case of a basic problem in applied measurement related to understanding whether a particular test provides accurate and useful information about the impact of an educational intervention. The three papers explore different aspects of the issue and highlight the potential benefits of (a) using particular research methods and of (b) implementing changes to educational policy that would strengthen efforts to reform instructional intervention in mathematics and science. The first paper investigates measurement problems related to the use of standardized tests in applied educational research. Analysis of the research projects funded by the Institute of Education Sciences (IES) Mathematics and Science Education Program permitted me to address three main research questions. One, how often are standardized tests used to evaluate new educational interventions? Two, do the tests appear to measure the same thing that the intervention teaches? Three, do investigators establish validity evidence for the specific uses of the test? The research documents potential problems and actual problems related to the use of standardized tests in leading applied research, and suggests changes to policy that would address measurement issues and improve the rigor of applied educational research. The second paper explores the practical consequences of misalignment between an outcome measure and an educational intervention in the context of summative evaluation. Simulated evaluation data and a psychometric model of alignment grounded in item response modeling generate the results that address the following research question: how do differences between what a test measures and what an intervention teaches influence the results of an evaluation? The simulation derives a functional relationship between alignment, defined as the match between the test and the intervention, and treatment sensitivity, defined as the statistical power for detecting the impact of an intervention. The paper presents a new model of the effect of misalignment on the results of an evaluation and recommendations for outcome measure selection. The third paper documents the educational effectiveness of the Learning Mathematics through Representations (LMR) lesson sequence for students classified as English Learners (ELs). LMR is a research-based curricular unit designed to support upper elementary students' understandings of integers and fractions, areas considered foundational for the development of higher mathematics. The experimental evaluation contains a multilevel analysis of achievement data from two assessments: a standardized test and a researcher-developed assessment. The study coordinates the two sources of research data with a theoretical mechanism of action in order to rigorously document the effectiveness and educational equity of LMR for ELs using multiple sources of information.

Defining and describing capacity issues in U.S. Doctor of Nursing Practice programs.

PubMed

Minnick, Ann F; Norman, Linda D; Donaghey, Beth

2013-01-01

Recent calls to expand the number of U.S. Doctors of Nursing Practice (DNPs) raises questions about programs' capacities, content and requirements, and their ability to expand. This paper aims to describe (1) key aspects of DNP program capacities that may provide direction for DNP program expansion plans, the timing of such expansion and program QI efforts; and (2) the impact of the DNP on faculty resources for research doctoral programs. A survey of all U.S. DNP programs (n = 130; response rate 72%) was conducted in 2011 based on previously tested items. Reviews of Web sites of nonresponding schools provided some data from all programs. Ratios of students to faculty active in advanced practice (AP) and in QI (QI) were high (AP 11.0:1, SD 10.1; QI 20.2:1, SD 17.0 respectively). There was wide variation in scholarly requirements (0-4: 50% of program had none) and program committee composition (1-5; mode=2). Almost all responding schools that offered PhD and DNP programs reported assigning research-active or potentially research-active faculty in both programs. The ability to expand programs while maintaining quality may be compromised by capacity issues. Addressing demand issues through the alignment of program requirements with societal and employment requirements may provide directions for addressing current DNP capacity issues. Copyright © 2013 Elsevier Inc. All rights reserved.

The core competency movement in marriage and family therapy: key considerations from other disciplines.

PubMed

Miller, John K; Todahl, Jeff L; Platt, Jason J

2010-01-01

There is a growing movement to define competency within the field of marriage and family therapy (MFT), particularly with respect to the training of practitioners and the evaluation of clinical practice. Efforts to define competency, however, transcend the practice of MFT and much can be learned from the experiences of other disciplines. Professions such as education, law, and medicine have made strides toward addressing the complex issue of competency standards in their respective fields. This article describes some ways in which the issue of competency has been approached in other professions, as well as some common dilemmas posed by adopting a competency-based orientation, to shed light on the process of defining competency in MFT. Moreover, this article identifies some of the more useful conceptualizations, modes of pedagogy, and evaluative practices found in other professions.

Concepcion de la Educacion Basica en Algunos Paises. Series Divulgaciones No. 1 (The Notion of Basic Education in Several Countries. Information Series No. 1).

ERIC Educational Resources Information Center

Enriquez, Galo, Ed.

This booklet defines and considers basic education and reports on the concept as it is implemented and developed in Argentina, Colombia, Chile, Spain, and Peru. Basic education, as defined here, generally refers to the education of children between the ages of 7 and 16 years. Initial remarks define the issue and discuss general principles. The…

The risks associated with falling parts of glazed facades in case of fire

NASA Astrophysics Data System (ADS)

Sędłak, Bartłomiej; Kinowski, Jacek; Sulik, Paweł; Kimbar, Grzegorz

2018-05-01

Arguably, one of the most important requirement a building have to meet in case of fire is to ensure the safe evacuation of its users and the work of rescue teams. Consequently, issues related to the risks associated with falling parts of facades are fairly well known around Europe. Even though not equally well defined as other fire safety requirements concerning glazed facades, there is plenty of test methods for assessment of facades regarding falling parts, mostly based on an approach related to fire spread. In this paper selection of test method for assessment of facades regarding falling parts is briefly presented. However, focus of this work is on fire test of typical glazed segment of façade performed in ITB Laboratory. Results of the test positively verifies conjecture that solutions with glass units configured with thin, tempered glass panes on the outer side should pose no threat. However, the question has been raised whether the behaviour of other glass unit solutions (with additional coatings or laminated) would be similar.

Defamation Issues in Higher Education.

ERIC Educational Resources Information Center

Bazluke, Francine Tilewick

This monograph reviews the law applying to defamation issues, cites various judicial decisions that affect colleges and universities, and offers guidance for minimizing the risk of defamation liability. It defines the two subclasses of defamatory statements: first, libel, which is a recorded or printed statement, and second, slander, which is…

Convergence or Divergence: Alignment of Standards, Assessment, and Issues of Diversity.

ERIC Educational Resources Information Center

Carter, Norvella, Ed.

In this report, teacher educators scrutinize the relationships between the standards and assessment movement in education and the United States' increasingly multicultural population. The papers include: "Foreword" (Jacqueline Jordan Irvine); (1) "Diversity and Standards: Defining the Issues" (Norvella P. Carter); (2) "Accountability and…

Issues in Transition.

ERIC Educational Resources Information Center

McNair, Jeff, Ed.; Kronick, Nancy, Ed.

Six papers address issues in the transition of students with disabilities into the adult world of work. In "Workplace Support," Jeff McNair defines "support," differentiates types of support, and considers various foci of intervention. The second paper titled, "Cross-Cultural Transition: An Exigent Topic for Study" by Nancy Kronick, reviews…

Research Priorities in Networking and Communications.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC.

A workshop focused on major research issues in networking and communications. This report defines the context for research priorities and initiatives and deals with issues in networking and communications. Fifteen major research priorities and four research specific initiatives were identified by participants as areas that should be pursued over…

IDRA Newsletter. Volume 35, No. 1

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2008-01-01

Each edition of the "IDRA (Intercultural Development Research Association) Newsletter" strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on parent and community engagement and includes: (1) Community Conversations about…

IDRA Newsletter. Volume 43, No. 7

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2016-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Teaching Quality and includes: (1) Fostering Culturally Diverse Learning Environments (Paula Johnson); (2) Unlocking Instruction…

Outlining ethical issues in nanotechnologies.

PubMed

Spagnolo, Antonio G; Daloiso, Viviana

2009-09-01

Nanotechnologies are an expression of the human ability to control and manipulate matter on a very small scale. Their use will enable an even and constant monitoring of human organisms, in a new and perhaps less invasive way. Debates at all levels--national, European and international--have pointed out the common difficulty of giving a complete, clear definition of nanotechnologies. This is primarily due to the variety of their components, to the fact that there is not just one technology but several. The most significant medical applications of nanotechnologies are in the diagnostic and the therapeutic fields, eg biosensors and molecular imaging, providing diagnosis and drug delivery with no invasive methods involved. Like any other emerging field, such technologies imply new possibilities for improving health but, on the other hand, they are still at an experimental stage and therefore should be implemented under rigorous safety testing before going on general release. For this purpose, the ethical, legal and social implications (ELSI) of nanotechnologies have been elaborated by study groups, in order to develop solutions before the results of the tests are diffused into medical practice. The aim of this paper is to define some of the ethical issues concerning biomedical applications and to evaluate whether there is a need for new or additional guidelines and regulations.

Military Health Care Dilemmas and Genetic Discrimination: A Family's Experience with Whole Exome Sequencing.

PubMed

Helm, Benjamin M; Langley, Katherine; Spangler, Brooke B; Schrier Vergano, Samantha A

2015-01-01

Whole-exome sequencing (WES) has increased our ability to analyze large parts of the human genome, bringing with it a plethora of ethical, legal, and social implications. A topic dominating discussion of WES is identification of "secondary findings" (SFs), defined as the identification of risk in an asymptomatic individual unrelated to the indication for the test. SFs can have considerable psychosocial impact on patients and families, and patients with an SF may have concerns regarding genomic privacy and genetic discrimination. The Genetic Information Nondiscrimination Act of 2008 (GINA) currently excludes protections for members of the military. This may cause concern in military members and families regarding genetic discrimination when considering genetic testing. In this report, we discuss a case involving a patient and family in which a secondary finding was discovered by WES. The family members have careers in the U.S. military, and a risk-predisposing condition could negatively affect employment. While beneficial medical management changes were made, the information placed exceptional stress on the family, who were forced to navigate career-sensitive "extra-medical" issues, to consider the impacts of uncovering risk-predisposition, and to manage the privacy of their genetic information. We highlight how information obtained from WES may collide with these issues and emphasize the importance of genetic counseling for anyone undergoing WES.

Experimental investigation of wave dispersion in hardened concrete and reference liquid media

NASA Astrophysics Data System (ADS)

Iliopoulos, Sokratis N.; Malm, Fabian; Grosse, Christian U.; Aggelis, Dimitrios G.

2017-04-01

Nowadays, more and more, the monitoring of concrete's setting and hardening as well as concrete's condition assessment and mechanical characterization is realized with the Ultrasonic Pulse Velocity technique. However, despite its increasing use, the high potential and the vast applicability over a wide range of materials and structures, the aforementioned nondestructive testing technique is only partially exploited since a) a default pulse usually not selected by the user is transmitted, b) a single frequency band dependent on the testing equipment (pulse generator and sensors) is excited and c) usually the first part of the signal is only considered. Moreover, the technique, as defined by its name, is based on pulse velocity measurements which strongly rely on a predefined threshold value for the calculation of the travel time between the transmitting and receiving sensor. To overcome all these issues, in the current experimental campaign, user-defined signals are generated, a broad range of ultrasonic frequencies is excited, while the full length of the signal is also taken into account. In addition, the pulse velocity measurements are replaced by the more advanced phase velocity calculations determined by reference phase points of the time domain signals or by phase differences of the signals transformed in the frequency domain. The experiments are mainly conducted in hardened concrete specimens but the aggregates are substituted by spherical glass beads of well-defined sizes and contents in order to better control the microstructure. Reference liquid media are also examined for comparison purposes. The results in both cases show strong dispersive trends indicated by significant changes in the phase velocity.

Maternal Neuroendocrine Serum Levels in Exclusively Breastfeeding Mothers

PubMed Central

Meltzer-Brody, Samantha; Pearson, Brenda; Pedersen, Cort; Grewen, Karen

2015-01-01

Abstract Background: Low milk supply is a common cause of early weaning, and supply issues are associated with dysregulation of thyroid function and prolactin. However, hormone levels compatible with successful breastfeeding are not well defined, limiting interpretation of clinical lab results. In this study we sought to quantify ranges for thyroid-stimulating hormone (TSH), free thyroxine (T4), total T4, and prolactin in a cohort of exclusively breastfeeding women. Materials and Methods: Women planning to breastfeed were recruited in the third trimester of pregnancy. Maternal endocrine function was assessed before and after a breastfeeding session at 2 and 8 weeks postpartum. We used paired t tests to determine whether values changed from the 2- to 8-week visit. Results: Of 52 study participants, 28 were exclusively breastfeeding, defined as only breastmilk feeds in the prior 7 days, at both the 2- and 8-week study visits. Endocrine function changed with time since delivery: the TSH level was higher, whereas total T4, free T4, and prolactin levels were lower, at the 8-week visit than at the 2-week visit (by paired t test, p≤0.01). We found a wide range of prolactin values at the 8-week visit, with a 5th percentile value of 9 ng/dL before feeding and 74 ng/dL at 10 minutes after feeding. Conclusions: Neuroendocrine function changes during the first 8 weeks after birth, and a wide range of values is compatible with successful breastfeeding. Further studies are needed to define reference values in breastfeeding women. PMID:25831434

Comparing measures of attachment: "To whom one turns in times of stress", parental warmth, and partner satisfaction.

PubMed

Lindberg, Marc A; Fugett, April; Thomas, Stuart W

2012-01-01

The Attachment and Clinical Issues Questionnaire (ACIQ; M. A. Lindberg & S. W. Thomas, 2011), was developed over an 18-year period containing 29 scales. The purpose of the present study was to test (a) the validity of the attachment scales in terms of how they predict to whom one turns in times of stress and for affective sharing, and (b) how the attachment scales compared with the Experiences in Close Relationship Questionnaire (ECR) in terms of concurrent, convergent, and discriminant evidence. The relevant secure scales of the ACIQ predicted to whom one turned in study 1, and study 2 demonstrated good convergent evidence with the ECR, but superior concurrent evidence in predicting partner satisfaction, and superior discriminant evidence in differentially correlating with mother and father warmth. Thus, the ACIQ passed essential validity and psychometric tests and was a more robust measure than the ECR with these defining characteristics of attachment.

Oromucosal film preparations: classification and characterization methods.

PubMed

Preis, Maren; Woertz, Christina; Kleinebudde, Peter; Breitkreutz, Jörg

2013-09-01

Recently, the regulatory authorities have enlarged the variety of 'oromucosal preparations' by buccal films and orodispersible films. Various film preparations have entered the market and pharmacopoeias. Due to the novelty of the official monographs, no standardized characterization methods and quality specifications are included. This review reports the methods of choice to characterize oromucosal film preparations with respect to biorelevant characterization and quality control. Commonly used dissolution tests for other dosage forms are not transferable for films in all cases. Alternatives and guidance on decision, which methods are favorable for film preparations are discussed. Furthermore, issues about requirements for film dosage forms are reflected. Oromucosal film preparations offer a wide spectrum of opportunities. There are a lot of suggestions in the literature on how to control the quality of these innovative products, but no standardized tests are available. Regulatory authorities need to define the standards and quality requirements more precisely.

Medical genetics, public understanding and patient experiences: An exploratory qualitative study of recently pregnant women

NASA Astrophysics Data System (ADS)

Garman, Jamie L.

The purpose of the study was to document how individuals' experiences and understanding of genetics concepts affects their medical experiences. Recently pregnant women were interviewed because they represent a population that needs to comprehend biological and genetic information to understand their health. Three women were designated as science experts (SE) defined as having extensive university level science education and three women were designated as science non-experts (SNE). In general, SEs described a more positive pregnancy experience. Both SEs and SNEs demonstrated a basic understanding of genetic concepts but varied in the application of concepts to personal medical issues. Participants' views and experiences of pre and postnatal tests were linked to their understanding of nature of science components such as recognition that tests have limitations. Results from this study indicate an incomplete understanding of the nature of science among participants may have led to unsatisfactory medical experiences.

Auris System: Providing Vibrotactile Feedback for Hearing Impaired Population

PubMed Central

Pereira Fonseca Dutra, Savio; Eduardo Coelho Freire Batista, Carlos

2017-01-01

Deafness, an issue that affects millions of people around the globe, is manifested in different intensities and related to many causes. This impairment negatively affects different aspects of the social life of the deaf people, and music-centered situations (concerts, religious events, etc.) are obviously not inviting for them. The Auris System was conceived to provide the musical experimentation for people who have some type of hearing loss. This system is able to extract musical information from audio and create a representation for music pieces using different stimuli, a new media format to be interpreted by other senses than the hearing. In addition, the system defines a testing methodology based on a noninvasive brain activity recording using an electroencephalographic (EEG) device. The results of the tests are being used to better understand the human musical cognition, in order to improve the accuracy of the Auris musical representation. PMID:29138749

Control of flexible structures

NASA Technical Reports Server (NTRS)

Russell, R. A.

1985-01-01

The requirements for future space missions indicate that many of these spacecraft will be large, flexible, and in some applications, require precision geometries. A technology program that addresses the issues associated with the structure/control interactions for these classes of spacecraft is discussed. The goal of the NASA control of flexible structures technology program is to generate a technology data base that will provide the designer with options and approaches to achieve spacecraft performance such as maintaining geometry and/or suppressing undesired spacecraft dynamics. This technology program will define the appropriate combination of analysis, ground testing, and flight testing required to validate the structural/controls analysis and design tools. This work was motivated by a recognition that large minimum weight space structures will be required for many future missions. The tools necessary to support such design included: (1) improved structural analysis; (2) modern control theory; (3) advanced modeling techniques; (4) system identification; and (5) the integration of structures and controls.

Methods and methodology for FTIR spectral correction of channel spectra and uncertainty, applied to ferrocene.

PubMed

Islam, M T; Trevorah, R M; Appadoo, D R T; Best, S P; Chantler, C T

2017-04-15

We present methodology for the first FTIR measurements of ferrocene using dilute wax solutions for dispersion and to preserve non-crystallinity; a new method for removal of channel spectra interference for high quality data; and a consistent approach for the robust estimation of a defined uncertainty for advanced structural χ r 2 analysis and mathematical hypothesis testing. While some of these issues have been investigated previously, the combination of novel approaches gives markedly improved results. Methods for addressing these in the presence of a modest signal and how to quantify the quality of the data irrespective of preprocessing for subsequent hypothesis testing are applied to the FTIR spectra of Ferrocene (Fc) and deuterated ferrocene (dFc, Fc-d 10 ) collected at the THz/Far-IR beam-line of the Australian Synchrotron at operating temperatures of 7K through 353K. Copyright © 2017 Elsevier B.V. All rights reserved.

Methods and methodology for FTIR spectral correction of channel spectra and uncertainty, applied to ferrocene

NASA Astrophysics Data System (ADS)

Islam, M. T.; Trevorah, R. M.; Appadoo, D. R. T.; Best, S. P.; Chantler, C. T.

2017-04-01

We present methodology for the first FTIR measurements of ferrocene using dilute wax solutions for dispersion and to preserve non-crystallinity; a new method for removal of channel spectra interference for high quality data; and a consistent approach for the robust estimation of a defined uncertainty for advanced structural χr2 analysis and mathematical hypothesis testing. While some of these issues have been investigated previously, the combination of novel approaches gives markedly improved results. Methods for addressing these in the presence of a modest signal and how to quantify the quality of the data irrespective of preprocessing for subsequent hypothesis testing are applied to the FTIR spectra of Ferrocene (Fc) and deuterated ferrocene (dFc, Fc-d10) collected at the THz/Far-IR beam-line of the Australian Synchrotron at operating temperatures of 7 K through 353 K.

Deceptive Advertising: Unprotected and Unknown.

ERIC Educational Resources Information Center

Ducoffe, Robert Hal

The Supreme Court tentatively extended First Amendment protection to commercial speech, but left the issue of defining and regulating deceptive advertising to the Federal Trade Commission (FTC), which has employed tools such as the cease-and-desist order, affirmative disclosure, and corrective advertising. The FTC Act did not define deception, but…

29 CFR 1952.160 - Description of the plan as initially approved.

Code of Federal Regulations, 2010 CFR

2010-07-01

... include both occupational safety and occupational health, the latter on a developmental basis. The plan defines the covered occupational safety and health issues as defined by the Secretary of Labor in 29 CFR... Section 1952.160 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH...

29 CFR 1952.320 - Description of the plan as initially approved.

Code of Federal Regulations, 2010 CFR

2010-07-01

... of Labor. (2) The plan defines the covered occupational safety and health issues as defined by the... Section 1952.320 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... Board of Health, Industrial Hygiene Division, pursuant to an agreement with the Division of Labor will...

29 CFR 1952.160 - Description of the plan as initially approved.

Code of Federal Regulations, 2011 CFR

2011-07-01

... include both occupational safety and occupational health, the latter on a developmental basis. The plan defines the covered occupational safety and health issues as defined by the Secretary of Labor in 29 CFR... Section 1952.160 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH...

29 CFR 1952.320 - Description of the plan as initially approved.

Code of Federal Regulations, 2011 CFR

2011-07-01

... of Labor. (2) The plan defines the covered occupational safety and health issues as defined by the... Section 1952.320 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... Board of Health, Industrial Hygiene Division, pursuant to an agreement with the Division of Labor will...

On the Relationships between (Relatively) Advanced Mathematical Knowledge and (Relatively) Advanced Problem-Solving Behaviours

ERIC Educational Resources Information Center

Koichu, Boris

2010-01-01

This article discusses an issue of inserting mathematical knowledge within the problem-solving processes. Relatively advanced mathematical knowledge is defined in terms of "three mathematical worlds"; relatively advanced problem-solving behaviours are defined in terms of taxonomies of "proof schemes" and "heuristic behaviours". The relationships…

Plurilingual Ethos: A Peep into the Sociology of Language.

ERIC Educational Resources Information Center

Khubchandani, Lachman M.

1998-01-01

Issues in the study of bilingualism and multilingualism in India and Pakistan are examined, including the delineation of linguistic boundaries, defining a society that is multicultural and yet has developed a "communication ethos" based on a core of common experience, the difficulty in interpreting language role and defining language…

Racism: Divided by Color. Multicultural Issues.

ERIC Educational Resources Information Center

Newman, Gerald; Layfield, Eleanor Newman

Racism can be defined as any attitude, belief, behavior, or institutional arrangement that favors one race or ethnic group over another. This discussion of racism for young people defines attitudinal racism, ideological racism, individual or group discrimination, and institutional racism as four aspects of racism in the United States. While some…

Understanding the Problem of Pornography.

ERIC Educational Resources Information Center

Metzger, Leigh Ann

This report was written to clarify the terms often associated with pornography and to help readers understand the issue of pornography more clearly. The first chapter defines pornography, as it was defined by the United States Attorney General's Commission on Pornography, as "that material (which) is predominantly sexually explicit and intended…

29 CFR 1952.310 - Description of the plan as initially approved.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 1952.310 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... and Industrial Relations as the agency responsible for administering the plan throughout the State. It proposes to define the occupational safety and health issues covered by it as defined by the Secretary of...

29 CFR 1952.110 - Description of the plan as initially approved.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 1952.110 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... Industrial Commission as the State agency designated to administer the plan throughout the State. It defines the covered occupational safety and health issues as defined by the Secretary of Labor in 29 CFR 1902...

29 CFR 1952.310 - Description of the plan as initially approved.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 1952.310 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... and Industrial Relations as the agency responsible for administering the plan throughout the State. It proposes to define the occupational safety and health issues covered by it as defined by the Secretary of...

29 CFR 1952.310 - Description of the plan as initially approved.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 1952.310 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... and Industrial Relations as the agency responsible for administering the plan throughout the State. It proposes to define the occupational safety and health issues covered by it as defined by the Secretary of...

29 CFR 1952.110 - Description of the plan as initially approved.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 1952.110 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... Industrial Commission as the State agency designated to administer the plan throughout the State. It defines the covered occupational safety and health issues as defined by the Secretary of Labor in 29 CFR 1902...

29 CFR 1952.110 - Description of the plan as initially approved.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 1952.110 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... Industrial Commission as the State agency designated to administer the plan throughout the State. It defines the covered occupational safety and health issues as defined by the Secretary of Labor in 29 CFR 1902...

Defining Disability for Women and the Problem of Unpaid Work.

ERIC Educational Resources Information Center

Reisine, Susan T.; Fifield, Judith

1988-01-01

Discusses political, theoretical, and methodological issues in defining and measuring paid and unpaid work disability. Presents results of study analyzing disability in paid work and unpaid family work among 206 women with rheumatoid arthritis, demonstrating feasibility of measuring disability in family work and showing that women experience…

Using SysML to model complex systems for security.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cano, Lester Arturo

2010-08-01

As security systems integrate more Information Technology the design of these systems has tended to become more complex. Some of the most difficult issues in designing Complex Security Systems (CSS) are: Capturing Requirements: Defining Hardware Interfaces: Defining Software Interfaces: Integrating Technologies: Radio Systems: Voice Over IP Systems: Situational Awareness Systems.

Defense Modeling and Simulation Initiative

DTIC Science & Technology

1992-05-01

project solicitation and priority ranking process, and reviewing policy issues . The activities of the DMSO and MSWG are also supported by a series of... issues have been raised for discussion, including: *Proumulgation of standards for the interoperability of models and simulations " Modeling and...have been completed or will be completed in the near term. The policy issues should be defined at a high level in the near term, although their

Language Policy in Canada: Current Issues. A Selection of the Proceedings of the Papers Dealing with Language Policy Issues in Canada at the Conference "Language Policy and Social Problems" (Curacao, Venezuela, December, 1983). Publication B-150.

ERIC Educational Resources Information Center

Cobarrubias, Juan, Ed.

The papers related to Canadian language policy at an international conference are presented: "Language Policy in Canada: Current Issues" (Juan Cobarrubias); "Multiculturalism and Language Policy in Canada" (Jim Cummins, Harold Troper); "Defining Language Policy in a Nationalistic Milieu and in a Complex Industrialized…

Study to define an approach for developing a computer-based system capable of automatic, unattended assembly/disassembly of spacecraft, phase 1

NASA Technical Reports Server (NTRS)

Nevins, J. L.; Defazio, T. L.; Seltzer, D. S.; Whitney, D. E.

1981-01-01

The initial set of requirements for additional studies necessary to implement a space-borne, computer-based work system capable of achieving assembly, disassembly, repair, or maintenance in space were developed. The specific functions required of a work system to perform repair and maintenance were discussed. Tasks and relevant technologies were identified and delineated. The interaction of spacecraft design and technology options, including a consideration of the strategic issues of repair versus retrieval-replacement or destruction by removal were considered along with the design tradeoffs for accomplishing each of the options. A concept system design and its accompanying experiment or test plan were discussed.

A view from the AIAA: Introduction of new energy storage technology into orbital programs

NASA Technical Reports Server (NTRS)

Badcock, Charles

1987-01-01

The development of new energy storage technology must be heavily weighted toward the application. The requirements for transitioning low risk technology into operational space vehicles must remain the central theme even at the preliminary development stages by the development of efforts to define operational issues and verify the reliability of the system. Failure to follow a complete plan that results in a flight qualified unit may lead to an orphan technology. Development efforts must be directed toward a stable development where changes in design are evolutionary and end items are equivalent to flight units so that life and qualification testing can be used as a vehicle to demonstrate the acceptability of the technology.

An assessment of faculty and dental student decision-making in ethics.

PubMed

Behar-Horenstein, Linda S; Catalanotto, Frank A; Garvan, Cynthia Wilson; Hudson-Vassell, Charisse

2014-01-01

This study reports and compares dental student and dental faculty scores to national norms for the Defining Issues Test 2, a measure of ethical decision-making competency. The findings showed that dental students and faculty tend to make decisions that promote self-interest, paralleling the ethical orientation of business professionals. Differences associated with gender, language, and norms from previous studies were observed. The findings underscore the importance of raising dental faculty and student awareness of their own ethical decision-making approaches. More importantly, the findings highlight the need to ensure that dental faculty have both the knowledge and skills to train dental students about the central role that ethical decision-making must play in patient care.

Weather Information Communication (WINCOMM) VDL-3 and 1090ES Final Test Requirements, Test Plans, and Test Results

NASA Technical Reports Server (NTRS)

Griner, James H.; Jirberg, Russ; Frantz, Brian; Kachmar, Brian A.

2006-01-01

NASA s Aviation Safety Program was created for the purpose of making a significant reduction in the incidents of weather related aviation accidents by improving situational awareness. The objectives of that program are being met in part through advances in weather sensor technology, and in part through advances in the communications technology that are developed for use in the National Airspace System. It is this latter element, i.e., the improvements in aviation communication technologies, that is the focus of the Weather Information Communications project. This report describes the final flight test results completed under the WINCOMM project at the NASA Glenn Research Center of the 1090 Extended Squitter (1090ES) and VDL Mode 3 (VDL-3) data links as a medium for weather data exchange. It presents the use of 1090ES to meet the program objectives of sending broadcast turbulence information and the use of VDL-3 to send graphical weather images. This report provides the test requirements and test plans, which led to flight tests, as well as final results from flight testing. The reports define the changes made to both avionics and ground-based receivers as well as the ground infrastructure to support implementation of the recommended architecture, with a focus on the issues associated with these changes.

Information Virtulization in Virtual Environments

NASA Technical Reports Server (NTRS)

Bryson, Steve; Kwak, Dochan (Technical Monitor)

2001-01-01

Virtual Environments provide a natural setting for a wide range of information visualization applications, particularly wlieit the information to be visualized is defined on a three-dimensional domain (Bryson, 1996). This chapter provides an overview of the issues that arise when designing and implementing an information visualization application in a virtual environment. Many design issues that arise, such as, e.g., issues of display, user tracking are common to any application of virtual environments. In this chapter we focus on those issues that are special to information visualization applications, as issues of wider concern are addressed elsewhere in this book.

IDRA Newsletter. Volume 44, No. 3

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2017-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Student Leadership and Engagement and includes: (1) Project Based Learning for Student Success--Teaching Across Content Areas for…

IDRA Newsletter. Volume 37, No. 4

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2010-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Parent and Community Engagement and includes: (1) Principles of Family Leadership in Education--Putting Principles into Action…

IDRA Newsletter. Volume 44, No. 5

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2017-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Family Leadership in Education and includes (1) IDRA Education CAFE--A Structure for Families Transforming Schools in their…

IDRA Newsletter. Volume 37, No. 2

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2010-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Teaching Quality and includes: (1) Ensuring Teaching Quality in a Civil Rights Context (Bradley Scott); (2) An Unspoken Culture…

New Options for the Modern Student. Info Brief. Number 50

ERIC Educational Resources Information Center

Eaton, Elizabeth; Nelson, Anne

2007-01-01

This issue of "Infobrief" concludes the exploration into the potential for high school reform in the United States. Earlier issues defined five components of an Association for Supervision and Curriculum Development (ASCD) proposal to effect reform: (1) multiple measures of assessment; (2) personalized learning strategies; (3) new models of…

An intelligent control system for rocket engines - Need, vision, and issues

NASA Technical Reports Server (NTRS)

Lorenzo, Carl F.; Merrill, Walter C.

1991-01-01

Several components of intelligence are defined. Within the context of these definitions an intelligent control system for rocket engines is described. The description includes a framework for development of an intelligent control system, including diagnostics, coordination, and direct control. Some current results and issues are presented.

41 CFR 101-39.208 - Vehicles removed from defined areas.

Code of Federal Regulations, 2010 CFR

2010-07-01

... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services... operated outside the geographical area served by the issuing GSA IFMS fleet management center. However... shall notify the issuing GSA IFMS fleet management center of the following: (1) The location at which...

Community Economic Vitality: Major Trends and Selected Issues.

ERIC Educational Resources Information Center

Summers, Gene F.; And Others

Intended for rural development practitioners and extension educators, this publication examines trends and issues in the revitalization of rural America. Chapter 1 defines community economic vitality as the capacity to ensure a flow of jobs and income over time; focuses attention on the realities of competition between communities and the…

Achieving Quality Learning in Higher Education.

ERIC Educational Resources Information Center

Nightingale, Peggy; O'Neil, Mike

This volume on quality learning in higher education discusses issues of good practice particularly action learning and Total Quality Management (TQM)-type strategies and illustrates them with seven case studies in Australia and the United Kingdom. Chapter 1 discusses issues and problems in defining quality in higher education. Chapter 2 looks at…

IDRA Newsletter. Volume 37, No. 1

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2010-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Curriculum Quality and includes: (1) Suggestions for Conducting Effective Teaching Demonstrations in Classrooms with Diverse Learners…

Corporate restructuring--strategic planning and redesign of employee benefits.

PubMed

Macey, S J

1996-12-01

Many intricate legal, actuarial, design and fiduciary issues arise during corporate restructuring. It is critical to create a process approach that clearly defines and evaluates the human resource and benefits issues that are involved, giving consideration to legal and regulatory, operational, administrative, financial and labor-related concerns.

African (Black) Psychology: Issues and Synthesis.

ERIC Educational Resources Information Center

Baldwin, Joseph A.

1986-01-01

Reviews the recent attempts of Black psychologists and social scientists to formulate a conceptual-operational framework for the study of psychological phenomena as they bear on the cultural-survival conditions of Black-African people. Outlines issues and problems in the attempt to define African (Black) psychology and discusses its relation to…

IDRA Newsletter. Volume 43, No. 3

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2016-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on College Preparedness and includes: (1) Ready Texas: Gathering Stakeholder Input to Guide Research on New Texas High School Graduation…

IDRA Newsletter. Volume 44, No. 4

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2017-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on School Integration and includes: (1) Using Socioeconomic Indicators as a Tool for School Diversity and Integration (David Hinojosa…

32 CFR 206.1 - Major characteristics of the NSEP institutional grants program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... issues of national capacity; and (3) Defines innovative approaches to issues not addressed by NSEP... base capacity currently exists in some foreign languages and area studies. It also recognizes that... cases where the demand cannot be met and encourages efforts that increase demand. (5) NSEP encourages...

32 CFR 206.1 - Major characteristics of the NSEP institutional grants program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... issues of national capacity; and (3) Defines innovative approaches to issues not addressed by NSEP... base capacity currently exists in some foreign languages and area studies. It also recognizes that... cases where the demand cannot be met and encourages efforts that increase demand. (5) NSEP encourages...

32 CFR 206.1 - Major characteristics of the NSEP institutional grants program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... issues of national capacity; and (3) Defines innovative approaches to issues not addressed by NSEP... base capacity currently exists in some foreign languages and area studies. It also recognizes that... cases where the demand cannot be met and encourages efforts that increase demand. (5) NSEP encourages...

32 CFR 206.1 - Major characteristics of the NSEP institutional grants program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... issues of national capacity; and (3) Defines innovative approaches to issues not addressed by NSEP... base capacity currently exists in some foreign languages and area studies. It also recognizes that... cases where the demand cannot be met and encourages efforts that increase demand. (5) NSEP encourages...

32 CFR 206.1 - Major characteristics of the NSEP institutional grants program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... issues of national capacity; and (3) Defines innovative approaches to issues not addressed by NSEP... base capacity currently exists in some foreign languages and area studies. It also recognizes that... cases where the demand cannot be met and encourages efforts that increase demand. (5) NSEP encourages...

Introduction to This Special Issue on Context-Aware Computing.

ERIC Educational Resources Information Center

Moran, Thomas P.; Dourish, Paul

2001-01-01

Discusses pervasive, or ubiquitous, computing; explains the notion of context; and defines context-aware computing as the key to disperse and enmesh computation into our lives. Considers context awareness in human-computer interaction and describes the broad topic areas of the essays included in this special issue. (LRW)

To Lease or Not To Lease.

ERIC Educational Resources Information Center

Hamilton, William A.

1998-01-01

Thanks to previous bond issues, the Walled Lake (Michigan) Schools had a well-defined technology plan featuring staff development, student performance benchmarks, and rooms of outdated computers. After three bond issues failed, the district adopted leasing as an alternative. Their present three-year contract supplies 154 used computers and a…

IDRA Newsletter. Volume 37, No. 8

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2010-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Change Strategies and includes: (1) YA! Es Tiempo--The Courage to Connect (Maria "Cuca" Robledo Montecel); (2) Making…

IDRA Newsletter. Volume 35, No. 3

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2008-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Curriculum Quality and includes: (1) IDRA's Community of Learners Approach to Instructional Quality: Three Critical Questions that…

IDRA Newsletter. Volume 37, No. 3

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2010-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Student Engagement and includes: (1) Supporting the Dream of Going to College Through Powerful Student Engagement (Hector Bojorquez);…

IDRA Newsletter. Volume 43, No. 8

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2016-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Accountability and Civic Engagement and includes: (1) Will States Use ESSA [Elementary and Secondary Education Act] to Undermine…

Information Liability--New Interpretations for Electronic Publishing.

ERIC Educational Resources Information Center

Tarter, Blodwen

1986-01-01

Defines the issue of information liability as it applies to electronic information and suggests ways in which the issue can be addressed and resolved. Discussion of the marketing and legal aspects of the question includes impact of the Dun & Bradstreet Inc. vs. Greenmoss Builders Inc. ruling on libel litigation. (EM)

We "Must" Integrate Human Rights into the Social Studies.

ERIC Educational Resources Information Center

O'Brien, Ed

1999-01-01

Asserts that educators need to teach about human rights issues, such as social and economic rights, in the social studies curriculum because these issues are disregarded throughout the country. Defines human rights, discusses the importance of the Universal Declaration of Human Rights (UDHR), and provides two lessons. (CMK)

IDRA Newsletter. Volume 44, No. 7

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2017-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Teaching Quality and includes: (1) Three Critical Areas of Professional Development for Teaching in 21st Century Classrooms (Paula…

IDRA Newsletter. Volume 43, No. 2

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2016-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Valuing & Asset-Based Solutions and includes: (1) Ensuring Equity and Nondiscrimination in Student Discipline Policy and Practice…

IDRA Newsletter. Volume 43, No. 5

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2016-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Student Voice and includes: (1) Youths in Action--Intergenerational Leadership (Aurelio M. Montemayor); (2) The Role of Conversation…

IDRA Newsletter. Volume 44, No. 9

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2017-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Push Outs -- Children of Color and includes: (1) Partnerships, Not Push Outs--Collaboration is Critical to Dealing with Disparities…

IDRA Newsletter. Volume 43, No. 1

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2016-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Language and includes: (1) Three Teaching Strategies for Scaffolding Instruction for English Learners in the Content Classroom (Paula…

Statewide Education Databases: Policy Issues. Discussion Draft.

ERIC Educational Resources Information Center

Hansen, Kenneth H.

This essay reviews current policy issues regarding statewide educational databases. It begins by defining the major characteristics of a database and raising two questions: (1) Is it really necessary to have a statewide educational database? (2) What is the primary rationale for creating one? The limitations of databases in formulating educational…

Financial Viability of Institutions. Issues in Post-Secondary Education.

ERIC Educational Resources Information Center

Jenny, Hans H.

Financial viability in postsecondary education is considered as part of the Postsecondary Education Core Design Project sponsored by the National Center for Education Statistics. Financial viability is defined within the scope of postsecondary education, and key policy issues at the national, state, and institutional levels are identified.…

Multisectoral Strategies for Advancing Girls' Education: Principles and Practice. SAGE Technical Report.

ERIC Educational Resources Information Center

Williams, Howard

This paper describes issues, experiences, and strategies used in developing successful multisectoral partnerships to advance girls' education, using Guinea and Morocco as examples. Chapter 1 introduces the issue, discussing barriers to girls' education and describing the multisectoral response to interrelated barriers. Chapter 2 defines the…

IDRA Newsletter. Volume 35, No. 7

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2008-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Teaching Quality and includes: (1) The "Fourth-Grade Slump" and Math Achievement: Addressing the Challenge with Student Engagement…

Terms vs. Concepts - The Case of Weight

NASA Astrophysics Data System (ADS)

Taibu, Rex

2017-01-01

Terminological and conceptual issues surrounding the definition of scientific terms have bothered teachers and students for many years. Some terms such as energy are not even usually defined, although they appear in different contexts of scientific communication, and others such as weight have debatable definitions, and for this reason the term weight is a great example to demonstrate general issues regarding terms and concepts. The term weight is defined in different ways, e.g., as the gravitational force or operationally as the force exerted by the body on its support. In an inertial situation, the magnitude of the gravitational force is equal to that of the support force. However, the two meanings are distinct when the object is in an accelerating situation (e.g., an accelerating elevator or on the surface of a rotating planet). Apart from these dichotomous definitions of weight, there are further language problems associated with each gravitational and operational definition of weight. This paper demonstrates these issues and asserts that arguing for which definition of weight is correct is not a viable approach to solve the language issue. The paper proposes an alternative route to deal with language issues facing weight and other related terms.

The Knowledge Society: Refounding the Socius

NASA Astrophysics Data System (ADS)

de Beer, Carel S.

The theme 'knowledge society' can have many meanings depending on who defines it. But can knowledge really define society since there are many other qualifying adjectives for society as well. What one should be preferred? Is knowledge a better qualifying term than risk, information, technology, or any other one? These questions need answers. There are many dreams and counter dreams regarding the ideal society. Some dreams, like Unesco's dream, focus on the self-evident issues in the knowledge society, or what people consider to be self-evident, or what is taken for granted, as if no exploration is required: issues like access to knowledge, knowledge management, knowledge sharing, etc. These dreams contain a threat despite promises of a future that cannot be achieved. Other dreams, like those of Ars Industrialis, dig deeper and look for founding possibilities, take nothing for granted, search for the original, the defining principles. These dreams bring hope and light, a future to live for.

What should we want to know about our future? A Kantian view on predictive genetic testing.

PubMed

Heinrichs, Bert

2005-01-01

Recent advances in genomic research have led to the development of new diagnostic tools, including tests which make it possible to predict the future occurrence of monogenetic diseases (e.g. Chorea Huntington) or to determine increased susceptibilities to the future development of more complex diseases (e.g. breast cancer). The use of such tests raises a number of ethical, legal and social issues which are usually discussed in terms of rights. However, in the context of predictive genetic tests a key question arises which lies beyond the concept of rights, namely, What should we want to know about our future? In the following I shall discuss this question against the background of Kant's Doctrine of Virtue. It will be demonstrated that the system of duties of virtue that Kant elaborates in the second part of his Metaphysics of Morals offers a theoretical framework for addressing the question of a proper scope of future knowledge as provided by genetic tests. This approach can serve as a source of moral guidance complementary to a justice perspective. It does, however, not rest on the-rather problematic--claim to be able to define what the "good life" is.

Inferring Genetic Ancestry: Opportunities, Challenges, and Implications

PubMed Central

Royal, Charmaine D.; Novembre, John; Fullerton, Stephanie M.; Goldstein, David B.; Long, Jeffrey C.; Bamshad, Michael J.; Clark, Andrew G.

2010-01-01

Increasing public interest in direct-to-consumer (DTC) genetic ancestry testing has been accompanied by growing concern about issues ranging from the personal and societal implications of the testing to the scientific validity of ancestry inference. The very concept of “ancestry” is subject to misunderstanding in both the general and scientific communities. What do we mean by ancestry? How exactly is ancestry measured? How far back can such ancestry be defined and by which genetic tools? How do we validate inferences about ancestry in genetic research? What are the data that demonstrate our ability to do this correctly? What can we say and what can we not say from our research findings and the test results that we generate? This white paper from the American Society of Human Genetics (ASHG) Ancestry and Ancestry Testing Task Force builds upon the 2008 ASHG Ancestry Testing Summary Statement in providing a more in-depth analysis of key scientific and non-scientific aspects of genetic ancestry inference in academia and industry. It culminates with recommendations for advancing the current debate and facilitating the development of scientifically based, ethically sound, and socially attentive guidelines concerning the use of these continually evolving technologies. PMID:20466090

Critical thinking, educational preparation, and development of moral judgment among selected groups of practicing nurses.

PubMed

Ketefian, S

1981-01-01

The focus of this descriptive study was the relationship between critical thinking, educational preparation, and level of moral judgment in 79 practicing nurses. The Watson-Glaser Critical Thinking Appraisal Test was used to measure critical thinking; information on the participating nurses' educational preparation was obtained from a personal information sheet. Moral judgment was measured by Rest's Defining Issues Test. The hypothesis that critical thinking would be positively related to moral judgment was tested by Pearson product moment correlation; the obtained coefficient of .5326 was significant at the .001 level. The hypothesis that there would be a difference between professional and technical nurses' moral judgments was tested through a one-way analysis of variance. The F ratio (F [1,77] = 9.6) was significant beyond the .01 level. Data also supported the hypothesis that critical thinking and educational preparation would predict greater variance in moral judgment than either variable alone, which was tested through multiple regression analysis (F [2,75] = 18.3, p = .01). Critical thinking and education together accounted for 32.9 percent of the variance in moral judgment. Implications of the findings are discussed for nursing research, practice, and education.

From the sea to the laboratory: Characterization of microplastic as prerequisite for the assessment of ecotoxicological impact.

PubMed

Potthoff, Annegret; Oelschlägel, Kathrin; Schmitt-Jansen, Mechthild; Rummel, Christoph Daniel; Kühnel, Dana

2017-05-01

The presence of microplastic (MP) in the aquatic environment is recognized as a global-scale pollution issue. Secondary MP particles result from an ongoing fragmentation process governed by various biotic and abiotic factors. For a reliable risk assessment of these MP particles, knowledge about interactions with biota is needed. However, extensive testing with standard organisms under reproducible laboratory conditions with well-characterized MP suspensions is not available yet. As MP in the environment represents a mixture of particles differing in properties (e.g., size, color, polymer type, surface characteristics), it is likely that only specific particle fractions pose a threat towards organisms. In order to assign hazardous effects to specific particle properties, these characteristics need to be analyzed. As shown by the testing of particles (e.g. nanoparticles), characteristics other than chemical properties are important for the emergence of toxicity in organisms, and parameters such as surface area or size distribution need consideration. Therefore, the use of "well-defined" particles for ecotoxicological testing (i.e., standard particles) facilitates the establishment of causal links between physical-chemical properties of MP particles and toxic effects in organisms. However, the benefits of well-defined particles under laboratory conditions are offset by the disadvantage of the unknown comparability with MP in the environment. Therefore, weathering effects caused by biological, chemical, physical or mechanical processes have to be considered. To date, the characterization of the progression of MP weathering based on powder and suspension characterization methods is in its infancy. The aim of this commentary is to illustrate the prerequisites for testing MP in the laboratory from 3 perspectives: (i) knowledge of particle properties; (ii) behavior of MP in test setups involving ecotoxicological test organisms; and (iii) accordingly, test conditions that may need adjustment. Only under those prerequisites will reliable hazard assessment of MP be feasible. Integr Environ Assess Manag 2017;13:500-504. © 2017 SETAC. © 2017 SETAC.

Building on common ground to address biodiversity conflicts and foster collaboration in environmental management.

PubMed

Lecuyer, Lou; White, Rehema M; Schmook, Birgit; Calmé, Sophie

2018-08-15

Conservation biology faces critical challenges that require collaborative approaches, including novel strategies to support interactions among actors in biodiversity conflicts. The goals of this study were to investigate the concept of common ground across multiple issues and to explore its practical application for the support of environmental management. We conceptually defined common ground as the areas of relevance underlying the suite of issues expressed by people regarding environmental management in a particular context. We then empirically tested this in the Calakmul region of Mexico, where the complex socio-historical context and high biodiversity have created environmental management challenges that are now being addressed by a local, multi-stakeholder management board. We conducted 26 open interviews with members of the board and a further round of quantitative prioritisation of issues raised. Using a coding process designed to reveal common ground, we categorized the issues at four levels ranging from coarse to fine (themes, topics, sub-topics and perspectives). We then analysed two levels, topics (n = 14 issues) and sub-topics (n = 51 issues). To do so, we built common ground matrices to identify and analyze common ground among actors and across issues. First, cluster and non-metrical data analyses revealed the diversity of actor positions and the lack of consistent grouping among actors by occupational activity. This demonstrated that focusing on actors' differences might be misleading, and that actors' views were not closely aligned with their roles. Second, we located issues according to their levels of common ground and importance among actors. We showed that by not focusing on single issue conflicts, the identification of common ground across multiple issues can pinpoint synergies. We then proposed a framework for collaboration that prioritizes issues of high importance with greater common ground (e.g. sustainable resource use activities), to support the development of trust and norms of reciprocity among actors, strengthening the potential for future cooperation. By adopting this approach, environmental managers could support the initial stages of collaborative conservation strategies, engaging with other actors to seek common ground, avoid the creation of polarised groups and help effectively manage biodiversity conflicts. Copyright © 2018 Elsevier Ltd. All rights reserved.

Identity Crisis: Defining the Problem and Framing a Solution for Terrorism Incident Response

DTIC Science & Technology

2007-09-01

government. Within two hours of the blast, the Oklahoma City Police Department ( OCPD ) had established a controlled perimeter around the incident site.4...Identification of personnel immediately became an issue. Initially, the OCPD moved its permit and identification section equipment to the scene to...issue identification badges. The operation lasted only a few hours as supplies were quickly exhausted.5 The OCPD continued to issue alternative forms

Neuromuscular Junction Formation between Human Stem cell-derived Motoneurons and Human Skeletal Muscle in a Defined System

PubMed Central

Guo, Xiufang; Gonzalez, Mercedes; Stancescu, Maria; Vandenburgh, Herman; Hickman, James

2011-01-01

Functional in vitro models composed of human cells will constitute an important platform in the next generation of system biology and drug discovery. This study reports a novel human-based in vitro Neuromuscular Junction (NMJ) system developed in a defined serum-free medium and on a patternable non-biological surface. The motoneurons and skeletal muscles were derived from fetal spinal stem cells and skeletal muscle stem cells. The motoneurons and skeletal myotubes were completely differentiated in the co-culture based on morphological analysis and electrophysiology. NMJ formation was demonstrated by phase contrast microscopy, immunocytochemistry and the observation of motoneuron-induced muscle contractions utilizing time lapse recordings and their subsequent quenching by D-Tubocurarine. Generally, functional human based systems would eliminate the issue of species variability during the drug development process and its derivation from stem cells bypasses the restrictions inherent with utilization of primary human tissue. This defined human-based NMJ system is one of the first steps in creating functional in vitro systems and will play an important role in understanding NMJ development, in developing high information content drug screens and as test beds in preclinical studies for spinal or muscular diseases/injuries such as muscular dystrophy, Amyotrophic lateral sclerosis and spinal cord repair. PMID:21944471

Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system.

PubMed

Guo, Xiufang; Gonzalez, Mercedes; Stancescu, Maria; Vandenburgh, Herman H; Hickman, James J

2011-12-01

Functional in vitro models composed of human cells will constitute an important platform in the next generation of system biology and drug discovery. This study reports a novel human-based in vitro Neuromuscular Junction (NMJ) system developed in a defined serum-free medium and on a patternable non-biological surface. The motoneurons and skeletal muscles were derived from fetal spinal stem cells and skeletal muscle stem cells. The motoneurons and skeletal myotubes were completely differentiated in the co-culture based on morphological analysis and electrophysiology. NMJ formation was demonstrated by phase contrast microscopy, immunocytochemistry and the observation of motoneuron-induced muscle contractions utilizing time-lapse recordings and their subsequent quenching by d-Tubocurarine. Generally, functional human based systems would eliminate the issue of species variability during the drug development process and its derivation from stem cells bypasses the restrictions inherent with utilization of primary human tissue. This defined human-based NMJ system is one of the first steps in creating functional in vitro systems and will play an important role in understanding NMJ development, in developing high information content drug screens and as test beds in preclinical studies for spinal or muscular diseases/injuries such as muscular dystrophy, Amyotrophic lateral sclerosis and spinal cord repair. Copyright © 2011 Elsevier Ltd. All rights reserved.

The evolving understanding of the construct of intellectual disability.

PubMed

Schalock, Robert L

2011-12-01

This article addresses two major areas concerned with the evolving understanding of the construct of intellectual disability. The first part of the article discusses current answers to five critical questions that have revolved around the general question, "What is Intellectual Disability?" These five are what to call the phenomenon, how to explain the phenomenon, how to define the phenomenon and determine who is a member of the class, how to classify persons so defined and identified, and how to establish public policy regarding such persons. The second part of the article discusses four critical issues that will impact both our future understanding of the construct and the approach taken to persons with intellectual disability. These four critical issues relate to the conceptualisation and measurement of intellectual functioning, the constitutive definition of intellectual disability, the alignment of clinical functions related to diagnosis, classification, and planning supports, and how the field resolves a number of emerging epistemological issues.

NASA Fastrac Engine Gas Generator Component Test Program and Results

NASA Technical Reports Server (NTRS)

Dennis, Henry J., Jr.; Sanders, T.

2000-01-01

Low cost access to space has been a long-time goal of the National Aeronautics and Space Administration (NASA). The Fastrac engine program was begun at NASA's Marshall Space Flight Center to develop a 60,000-pound (60K) thrust, liquid oxygen/hydrocarbon (LOX/RP), gas generator-cycle booster engine for a fraction of the cost of similar engines in existence. To achieve this goal, off-the-shelf components and readily available materials and processes would have to be used. This paper will present the Fastrac gas generator (GG) design and the component level hot-fire test program and results. The Fastrac GG is a simple, 4-piece design that uses well-defined materials and processes for fabrication. Thirty-seven component level hot-fire tests were conducted at MSFC's component test stand #116 (TS116) during 1997 and 1998. The GG was operated at all expected operating ranges of the Fastrac engine. Some minor design changes were required to successfully complete the test program as development issues arose during the testing. The test program data results and conclusions determined that the Fastrac GG design was well on the way to meeting the requirements of NASA's X-34 Pathfinder Program that chose the Fastrac engine as its main propulsion system.

Teaching the Interrelationships among Costs, Expense, and Liability of a Defined Benefit Pension Plan

ERIC Educational Resources Information Center

Wilson, Arlette C.; Godwin, Norman H.

2008-01-01

The Financial Accounting Standards Board (FASB) recently issued Statement of Financial Accounting Standards No. 158 "Employers' Accounting for Defined Benefit Pension and Other Postretirement Plans" (SFAS #158). Their intent is to comprehensively reconsider the accounting for postretirement benefit plans in phases. The first phase was to provide…

29 CFR 1952.310 - Description of the plan as initially approved.

Code of Federal Regulations, 2011 CFR

2011-07-01

... proposes to define the occupational safety and health issues covered by it as defined by the Secretary of Labor in 29 CFR 1902.2(c)(1). All occupational safety and health standards promulgated by the U.S... Section 1952.310 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH...

29 CFR 1952.310 - Description of the plan as initially approved.

Code of Federal Regulations, 2010 CFR

2010-07-01

... proposes to define the occupational safety and health issues covered by it as defined by the Secretary of Labor in 29 CFR 1902.2(c)(1). All occupational safety and health standards promulgated by the U.S... Section 1952.310 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH...

Choosing Pre-conception Planning for Women/Families: Counselling and Informed Consent (Part 2) - Pre-conception Reproductive Planning, Lifestyle, Immunization, and Psychosocial Issues.

PubMed

Wilson, R Douglas

2017-12-06

To inform reproductive and other health care providers about pre-conception evaluation, including considerations for reproductive planning, lifestyle modification, immunization status and attitudes, and psychosocial issues. This counselling information can be used for patient education and planning and possible pre-conception and/or prenatal testing. This information may allow for improved risk assessment when pre-conception counselling for individual patients and their families is used. CONSIDERATIONS FOR PRE-CONCEPTION CARE (PART 2) REGARDING PRE-CONCEPTION REPRODUCTIVE PLANNING, LIFESTYLE, IMMUNIZATIONS, AND PSYCHOSOCIAL ISSUES: CONSIDERATION FOR CARE STATEMENTS: For this review article, the Consideration for Care Statements use the Grading of Recommendations, Assessment, Development and Evaluations strength and quality principles because they are comparable for the clinician and the patient/public user. For example, "Strong" for clinicians is defined as "the recommendation would apply to most individuals. Formal discussion aids are not likely to be needed to help individuals make decisions consistent with their values and preferences." For patients/the public, "Strong" is defined as, "we believe most people in this situation would want the recommended course of actions and only a small number would not." Quality of evidence (High, Moderate, Low) is based on the confidence that the true effect lies close to that of the estimate of the effect. In addition, the Canadian Task Force on Preventive Health Care key to evidence statements and grading of recommendations are included. PubMed, Medline, and the Cochrane Database were searched until May 2017, using appropriate key words (i.e., preconception, reproductive planning, lifestyle modification, immunization risks and benefits, psychosocial pregnancy factors/issues). Grey (unpublished) literature was identified through searching websites of health technology assessment and health technology assessment-related agencies, clinical practice guideline collections, and national and international medical specialty societies. The benefits for the patient and her family from receiving this pre-conception counseling would include an increased understanding of the relevant issues for both pre-conception and in early pregnancy as well as better pregnancy outcomes. Harm includes potential increased anxiety or psychological stress associated with the possibility of identifying maternal pregnancy risks. Copyright © 2017 Society of Obstetricians and Gynaecologists of Canada. Published by Elsevier Inc. All rights reserved.

Direct dosing of preweaning rodents in toxicity testing and research: deliberations of an ILSI RSI Expert Working Group.

PubMed

Moser, Virginia C; Walls, Isabel; Zoetis, Tracey

2005-01-01

Laboratory animal studies designed to assess the effects of exposure of a test substance during postnatal development are commonly utilized in basic research and to evaluate potential hazard to children for chemical and pharmaceutical regulation. Direct dosing, defined here as the administration of a test substance directly to a preweaning mammal, has been identified as a useful tool that can be used in the conduct of such studies for regulatory purposes. The International Life Sciences Institute Risk Science Institute (ILSI RSI) convened an Expert Working Group to develop guidance on the design and implementation of direct dosing regulatory studies on preweaning mammals, which was published as an ILSI monograph in 2003 (Zoetis and Walls, Principles and Practices for Direct Dosing of Pre-Weaning Mammals in Toxicity Testing and Research, Washington, DC: ILSI Press, 2003). A summary of the Working Group conclusions regarding direct dosing studies with laboratory rodents are presented here, although the ILSI monograph also includes rabbits, canines, swine and nonhuman primates. Issues to be considered when designing the protocol include selection of the test species, the route of administration, dose levels, and the timing of dosing. Knowledge of the maturational status of the test species and information on critical windows of development are important in creating a valid study design. Most common routes of administration (e.g., oral, inhalation, injection) are possible with typical laboratory species; however, adjustments may be necessary due to practical considerations. Information on the pharmacokinetic profile in young animals versus adults and in the test species versus humans is very useful for determining dosing parameters. The conduct of the study and the interpretation of the data will be improved by an understanding of confounding factors as well as statistical and biological issues specific for postnatal studies. Ultimately, the success of the study will depend upon careful preparation, including thorough training of the technical staff.

Physics issues of gamma ray burst emissions

NASA Technical Reports Server (NTRS)

Liang, Edison

1987-01-01

The critical physics issues in the interpretation of gamma-ray-burst spectra are reviewed. An attempt is made to define the emission-region parameter space satisfying the maximum number of observational and theoretical constraints. Also discussed are the physical mechanisms responsible for the bursts that are most consistent with the above parameter space.

29 CFR 1952.240 - Description of the plan as initially approved.

Code of Federal Regulations, 2010 CFR

2010-07-01

... occupational safety and health issues as defined by the Secretary of Labor in § 1902.2(c)(1) of this chapter... standards and issue rules and regulations necessary for the implementation of the safety and health law. (d... Section 1952.240 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH...

29 CFR 1952.240 - Description of the plan as initially approved.

Code of Federal Regulations, 2011 CFR

2011-07-01

... occupational safety and health issues as defined by the Secretary of Labor in § 1902.2(c)(1) of this chapter... standards and issue rules and regulations necessary for the implementation of the safety and health law. (d... Section 1952.240 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH...

Basic Policy Studies Skills.

ERIC Educational Resources Information Center

Coplin, William D., Ed.; O'Leary, Michael K., Ed.

This publication will help high school and college students develop policy analysis skills and techniques and apply these to important public issues. A public policy issue is defined as a disagreement between two or more elements of a society over the way that the society's government deals with a given situation. There are six chapters. Chapter…

Ethics on Trial: Teacher's Guide for Secondary Schools.

ERIC Educational Resources Information Center

Greater Washington Educational Telecommunications Association, Inc., Arlington, VA.

Students' understanding of lawyers and the legal system may be increased through the five law-related ethical issues presented in this document. Legal ethics is defined as: (1) the minimum standard of professional conduct in daily legal situations; and (2) a lawyer's broader responsibility to society. The ethical issues are presented in three…

IDRA Newsletter. Volume 44, No. 10, November-December 2017

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2017-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Principal Leadership and includes: (1) The Power of Partnerships in the Pursuit of Leadership Development to Transform Schools (Nilka…

Latchkey Children and School-Age Child Care: A Background Briefing. Policy Issues.

ERIC Educational Resources Information Center

Fink, Dale B.

This background briefing paper synthesizes current thinking and practice on the issue of latchkey children and school-age child care (SACC). The paper defines the problem of latchkey children; reviews related literature and programmatic responses to the problem; reports responses of four southern states; and points out implications for policy…

Facts for a Change: Citizen Action Research for Better Schools.

ERIC Educational Resources Information Center

Burges, Bill

In an action research project, local citizens and community groups (often in collaboration with school professionals) investigate community-defined issues. Action research is geared to help people think clearly about an issue and find the resources they need to face it. In such a project, citizens develop skills in organizing, finding resources,…

Violence and the Media: Teaching Strategies and a Rationale.

ERIC Educational Resources Information Center

Gathercoal, Paul

This paper suggests teaching strategies for grades 4 through 12 that examine the commercial media and their messages as agenda setters, i.e., as mechanisms for selecting social issues, establishing their importance, and defining socially acceptable attitudes and responses to those issues. The strategies also explore how the media can create biased…

Comparable Worth and the Office of Institutional Research. AIR 1986 Annual Forum Paper.

ERIC Educational Resources Information Center

Budig, Jeanne E.

Comparable worth and pay equity issues are considered, along with implications for college institutional researchers. Comparable worth is generally defined as a policy of paying equal pay for work of comparable value. After discussing the issues and tracing relevant legislation, attention is directed to ways that the institutional research office…

IDRA Newsletter. Volume 44, No. 2

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2017-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on college bound students and includes: (1) Since When are Good Grades and Diversity a Bad Thing? Recommendations and the Texas Top Ten…

IDRA Newsletter. Volume 44, No. 6, June-July 2017

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2017-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Using Data for Action and includes: (1) Community and School Use of Data for College Readiness and Postsecondary Success (Karmen…

Space station architectural elements and issues definition study

NASA Technical Reports Server (NTRS)

Taylor, T. C.; Spencer, J. S.; Rocha, C. J.

1986-01-01

A study was conducted to define the architectural elements and issues of the Space Station. The objective of the study was to identify those questions which require further research and suggest ways in which the research can be undertaken. The study examined five primary topics, asked salient questions and described the merits of alternative solutions.

IDRA Newsletter. Volume 43, No. 4

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2016-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Early Learning and includes: (1) Three Signs that Your Pre-K Might Need a Make Over (Felix Montes); (2) Bilingual Early Childhood…

IDRA Newsletter. Volume 43, No. 6, June-July 2016

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2016-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Culture of Poverty vs. Culture of Possibility and includes: (1) Open Source Learning Tools Make STEM Possible in Underserved Schools…

Teaching Sustainability as a Social Issue: Learning from Three Teachers

ERIC Educational Resources Information Center

Shuttleworth, Jay M.

2013-01-01

Many researchers cite living more sustainably as humans' most pressing long- term challenge. Living sustainably can be defined as meeting one's needs without interfering with future generations ability to meet their needs. Engaging students with the social causes and effects of sustainability issues may help to address and create…

The New Literacies of Online Reading Comprehension: Expanding the Literacy and Learning Curriculum

ERIC Educational Resources Information Center

Leu, Donald J.; McVerry, J. Gregory; O'Byrne, W. Ian; Kiili, Carita; Zawilinski, Lisa; Everett-Cacopardo, Heidi; Kennedy, Clint; Forzani, Elena

2011-01-01

This commentary explores a central issue for our times, online reading comprehension. It first defines three issues that have largely gone unnoticed as the Internet enters our classrooms: (1) literacy has become deictic; (2) effective online information use requires additional online reading comprehension practices, skills, and dispositions; and…

Supervision of Marriage and Family Counselors. ERIC Digest.

ERIC Educational Resources Information Center

Cryder, Annette Petro; And Others

This digest focuses on issues of importance to the supervision of marriage and family counselors. A brief overview notes that the defining hallmark of marriage and family supervision has been a systemic orientation. Other distinguishing features include a reliance on live forms of supervision, and the viewing of ethical issues within larger…

IDRA Newsletter. Volume 44, No. 8

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2017-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Culture of Poverty Myths and includes: (1) Tying the Knot Between School Finance Policy and Serving All Students (David G. Hinojosa);…

IDRA Newsletter. Volume 43, No. 9

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2016-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Push Outs--Children of Color and includes: (1) Texas Public School Attrition Study, 2015-16: High School Attrition Inches Up to 25…

IDRA Newsletter. Volume 37, No.5

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2010-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Fair Funding and includes: (1) Fair Funding of Texas Schools is Even More Critical in Tough Economic Times (Albert Cortez); (2)…

Sexual Harassment: What's Good for the Goose Is Good For the Gander.

ERIC Educational Resources Information Center

Hazzard, Terry

Sexual harassment, once an issue only among women, is becoming a serious issue among men. The number of law suits brought by men alleging sexual harassment is increasing and will likely continue to increase as more women attain supervisory and management positions. The Equal Employment Opportunity Commission (EEOC) defines harassment as…

Scaffolding and Dialogic Teaching in Mathematics Education: Introduction and Review

ERIC Educational Resources Information Center

Bakker, Arthur; Smit, Jantien; Wegerif, Rupert

2015-01-01

This article has two purposes: firstly to introduce this special issue on scaffolding and dialogic teaching in mathematics education and secondly to review the recent literature on these topics as well as the articles in this special issue. First we define and characterise scaffolding and dialogic teaching and provide a brief historical overview…

Collision of Epistemological Frameworks: Religion and Social Science's Unshared Understanding of Ethics

ERIC Educational Resources Information Center

Firmin, Michael W.

2009-01-01

Religious scholars and social science experts frequently differ and sometimes clash when writing and discussing issues of ethics. Sometimes unshared understandings on fundamental world-view issues is the etiology for these differences. Differences in defining truth, whether philosophically or empirically, often is at the root etiology in these…

Legislation on direct-to-consumer genetic testing in seven European countries.

PubMed

Borry, Pascal; van Hellemondt, Rachel E; Sprumont, Dominique; Jales, Camilla Fittipaldi Duarte; Rial-Sebbag, Emmanuelle; Spranger, Tade Matthias; Curren, Liam; Kaye, Jane; Nys, Herman; Howard, Heidi

2012-07-01

An increasing number of private companies are now offering direct-to-consumer (DTC) genetic testing services. Although a lot of attention has been devoted to the regulatory framework of DTC genetic testing services in the USA, only limited information about the regulatory framework in Europe is available. We will report on the situation with regard to the national legislation on DTC genetic testing in seven European countries (Belgium, the Netherlands, Switzerland, Portugal, France, Germany, the United Kingdom). The paper will address whether these countries have legislation that specifically address the issue of DTC genetic testing or have relevant laws that is pertinent to the regulatory control of these services in their countries. The findings show that France, Germany, Portugal and Switzerland have specific legislation that defines that genetic tests can only be carried out by a medical doctor after the provision of sufficient information concerning the nature, meaning and consequences of the genetic test and after the consent of the person concerned. In the Netherlands, some DTC genetic tests could fall under legislation that provides the Minister the right to refuse to provide a license to operate if a test is scientifically unsound, not in accordance with the professional medical practice standards or if the expected benefit is not in balance with the (potential) health risks. Belgium and the United Kingdom allow the provision of DTC genetic tests.

Legislation on direct-to-consumer genetic testing in seven European countries

PubMed Central

Borry, Pascal; van Hellemondt, Rachel E; Sprumont, Dominique; Jales, Camilla Fittipaldi Duarte; Rial-Sebbag, Emmanuelle; Spranger, Tade Matthias; Curren, Liam; Kaye, Jane; Nys, Herman; Howard, Heidi

2012-01-01

An increasing number of private companies are now offering direct-to-consumer (DTC) genetic testing services. Although a lot of attention has been devoted to the regulatory framework of DTC genetic testing services in the USA, only limited information about the regulatory framework in Europe is available. We will report on the situation with regard to the national legislation on DTC genetic testing in seven European countries (Belgium, the Netherlands, Switzerland, Portugal, France, Germany, the United Kingdom). The paper will address whether these countries have legislation that specifically address the issue of DTC genetic testing or have relevant laws that is pertinent to the regulatory control of these services in their countries. The findings show that France, Germany, Portugal and Switzerland have specific legislation that defines that genetic tests can only be carried out by a medical doctor after the provision of sufficient information concerning the nature, meaning and consequences of the genetic test and after the consent of the person concerned. In the Netherlands, some DTC genetic tests could fall under legislation that provides the Minister the right to refuse to provide a license to operate if a test is scientifically unsound, not in accordance with the professional medical practice standards or if the expected benefit is not in balance with the (potential) health risks. Belgium and the United Kingdom allow the provision of DTC genetic tests. PMID:22274578

First-Order Open-Universe POMDPs: Formulation and Algorithms

DTIC Science & Technology

2013-12-25

A full DTBLOG model for the airport domain example is presented in the appendix. Let M ( S , A ) be a DTBLOG model defined using the sets S and A of...respectively. IfM satisfies BLOG’s requirements for well-defined probabilistic models then it constitutes a well-defined OUPOMDP model wrt S and A . Actions on... a first-order, open-universe language to describe POMDPs and identify non-trivial representational issues in describing an agent? s

Ethics in Prion Disease

PubMed Central

Bechtel, Kendra; Geschwind, Michael D.

2013-01-01

This paper is intended to discuss some of the scientific and ethical issues that are created by increased research efforts towards earlier diagnosis, as well as to treatment of, human prion diseases (and related dementias), including the resulting consequences for individuals, their families, and society. Most patients with prion disease currently are diagnosed when they are about 2/3 of the way through their disease course (Geschwind, Kuo et al. 2010; Paterson, Torres-Chae et al. 2012), when the disease has progressed so far that even treatments that stop the disease process would probably have little benefit. Although there are currently no treatments available for prion diseases, we and others have realized that we must diagnose patients earlier and with greater accuracy so that future treatments have hope of success. As approximately 15% of prion diseases have a autosomal dominant genetic etiology, this further adds to the complexity of ethical issues, particularly regarding when to conduct genetic testing, release of genetic results, and when or if to implement experimental therapies. Human prion diseases are both infectious and transmissible; great care is required to balance the needs of the family and individual with both public health needs and strained hospital budgets. It is essential to proactively examine and address the ethical issues involved, as well as to define and in turn provide best standards of care. PMID:23906487

Neural Correlates of Post-Conventional Moral Reasoning: A Voxel-Based Morphometry Study

PubMed Central

Prehn, Kristin; Korczykowski, Marc; Rao, Hengyi; Fang, Zhuo; Detre, John A.; Robertson, Diana C.

2015-01-01

Going back to Kohlberg, moral development research affirms that people progress through different stages of moral reasoning as cognitive abilities mature. Individuals at a lower level of moral reasoning judge moral issues mainly based on self-interest (personal interests schema) or based on adherence to laws and rules (maintaining norms schema), whereas individuals at the post-conventional level judge moral issues based on deeper principles and shared ideals. However, the extent to which moral development is reflected in structural brain architecture remains unknown. To investigate this question, we used voxel-based morphometry and examined the brain structure in a sample of 67 Master of Business Administration (MBA) students. Subjects completed the Defining Issues Test (DIT-2) which measures moral development in terms of cognitive schema preference. Results demonstrate that subjects at the post-conventional level of moral reasoning were characterized by increased gray matter volume in the ventromedial prefrontal cortex and subgenual anterior cingulate cortex, compared with subjects at a lower level of moral reasoning. Our findings support an important role for both cognitive and emotional processes in moral reasoning and provide first evidence for individual differences in brain structure according to the stages of moral reasoning first proposed by Kohlberg decades ago. PMID:26039547

Enhanced Damage-Resistant Optics for Spaceflight Laser Systems: Workshop findings and recommendations

NASA Technical Reports Server (NTRS)

Schulze, Norman; Cimolino, Marc; Guenther, Arthur; Mcminn, Ted; Rainer, Frank; Schmid, Ansgar; Seitel, Steven C.; Soileau, M. J.; Theon, John S.; Walz, William

1991-01-01

NASA has defined a program to address critical laser-induced damage issues peculiar to its remote sensing systems. The Langley Research Center (LaRC), with input from the Goddard Space Flight Center (GSFC), has developed a program plan focusing on the certification of optical materials for spaceflight applications and the development of techniques to determine the reliability of such materials under extended laser exposures. This plan involves cooperative efforts between NASA and optics manufacturers to quantify the performance of optical materials for NASA systems and to ensure NASA's continued application of the highest quality optics possible for enhanced system reliability. A review panel was organized to assess NASA's optical damage concerns and to evaluate the effectiveness of the LaRC proposed program plan. This panel consisted of experts in the areas of laser-induced damage, optical coating manufacture, and the design and development of laser systems for space. The panel was presented information on NASA's current and planned laser remote sensing programs, laser-induced damage problems already encountered in NASA systems, and the proposed program plan to address these issues. Additionally, technical presentations were made on the state of the art in damage mechanisms, optical materials testing, and issues of coating manufacture germane to laser damage.

A new bioimpedance research device (BIRD) for measuring the electrical impedance of acupuncture meridians.

PubMed

Wong, Felix Wu Shun; Lim, Chi Eung Danforn; Smith, Warren

2010-03-01

The aim of this article is to introduce an electrical bioimpedance device that uses an old and little-known impedance measuring technique to study the impedance of the meridian and nonmeridian tissue segments. Three (3) pilot experimental studies involving both a tissue phantom (a cucumber) and 3 human subjects were performed using this BIRD-I (Bioimpedance Research Device) device. This device consists of a Fluke RCL meter, a multiplexer box, a laptop computer, and a medical-grade isolation transformer. Segment and surface sheath (or local) impedances were estimated using formulae first published in the 1930s, in an approach that differs from that of the standard four-electrode technique used in most meridian studies to date. Our study found that, when using a quasilinear four-electrode arrangement, the reference electrodes should be positioned at least 10 cm from the test electrodes to ensure that the segment (or core) impedance estimation is not affected by the proximity of the reference electrodes. A tissue phantom was used to determine the repeatability of segment (core) impedance measurement by the device. An applied frequency of 100 kHz was found to produce the best repeatability among the various frequencies tested. In another preliminary study, with a segment of the triple energizer meridian on the lower arm selected as reference segment, core resistance-based profiles around the lower arm showed three of the other five meridians to exist as local resistance minima relative to neighboring nonmeridian segments. The profiles of the 2 subjects tested were very similar, suggesting that the results are unlikely to be spurious. In electrical bioimpedance studies, it is recommended that the measuring technique and device be clearly defined and standardized to provide optimal working conditions. In our study using the BIRD I device, we defined our standard experimental conditions as a test frequency of 100 kHz and the position of the reference electrodes of at least 10 cm from the test electrodes. Our device has demonstrated potential for use in quantifying the degree of electrical interconnection between any two surface-defined test meridian or nonmeridian segments. Issues arising from use of this device and the measurement Horton and van Ravenswaay technique were also presented.

End-of Life Issues in the Context of Alzheimer’s Disease

PubMed Central

Allen, Rebecca S.; Kwak, Jung; Lokken, Kristine L.; Haley, William E.

2009-01-01

This article presents an overview of end-of-life care for individuals with Alzheimer’s disease (AD) and their family caregivers. We define end-stage AD, and review neuropsychological and behavioral characteristics along with concomitant issues in therapeutic assessment. We then review the literature regarding programs and treatments for end-stage AD, the need for advance care planning and family participation in medical decision-making, familial caregiving stress, and issues associated with palliative care and bereavement outcomes. Methodological issues in the extant research literature are addressed, including issues of treatment implementation, validity, and clinical significance. Translational research and demonstration projects are encouraged. PMID:19997523

critcial human health issues in connection with future human missions to mMars: the HUMEX study of ESA

NASA Astrophysics Data System (ADS)

Horneck, G.; Humex Team

ESA has recently initiated a study of the human responses, limits and needs with regard to the stress environments of interplanetary and planetary missions. Emphasis was laid on human health and performance care as well as Advanced Life Support Developments including Bioregenerative Life Support Systems and environmental monitoring. The overall study goals were as follows: (i) to define reference scenarios for a European participation in human exploration and to estimate their influence on the Life Sciences and Life Support requirements; (ii) for selected mission scenarios, to critically assess the limiting factors for human health, wellbeing, and performance and to recommend relevant countermeasures; (iii) for selected mission scenarios, to critically assess the potential of Advanced Life Support Developments and to pro-pose a European strategy including terrestrial applications; (iv) to critically assess the feasibility of existing facilities and technologies on ground and in space as test-beds in preparation for human exploratory missions and to develop a test plan for ground and ISS campaigns; (v) to develop a roadmap for a future European strategy towards human exploratory missions, including preparatory activities and terrestrial applications and benefits. Two scenarios for a Mars mission were selected: (i) with a 30 days stay on Mars, and (ii) with about 500 days stay on Mars. The impact on human health, perform-ance and well being has been investigated from the view point of (i) the effects of microgravity (during space travel), reduced gravity (on Mars) and abrupt gravity changes (during launch and landing), (ii) the effects of cosmic radiation including solar particle events, (iii) psychological issues as well as general health care. Coun-termeasures as well as necessary research using ground-based testbeds and/or the ISS have been defined. The need for highly intelligent autonomous diagnostic and therapy systems was emphasized. Advanced life support systems with a high degree of autonomy and regenerative capacity and synergy effects were considered where bioregenerative life support systems and biodiagnostic systems become essential especially for the long-term Mars scenario. The considerations have been incorpo-rated into a roadmap for a future European strategy in human health issues for a potential European participation in a cooperative international exploration of our solar system by humans. Ref. Horneck et al, 2003, HUMEX, study on the Survivability and Adaptation of Humans to Long-Duration Exploratory Missions, ESA SP 1264

Tactical Level Command and Control and Decision Making Utilizing FBCB2-BFT

DTIC Science & Technology

2010-09-01

area. Due to the inherent uncertainty of battle (fog of war) and the limited range of radio communications, mission type orders were issued that...existence 8 of a tactical level was simply a reflection of the practical issues that face commanders, and the control measures that they adopt to...overcome them. These “ issues ” included the “geography they operate in, the scale of forces involved, and the technology that defines the

40 CFR 86.1806-05 - On-board diagnostics for vehicles less than or equal to 14,000 pounds GVWR.

Code of Federal Regulations, 2012 CFR

2012-07-01

... once per applicable certification test cycle as defined in paragraphs (a) and (d) of Appendix I of this...-based test procedures), excluding those test procedures defined as “Supplemental” test procedures in... infeasibility. Malfunctions are defined as a failure of the system or component to meet the electrical circuit...

40 CFR 86.1806-05 - On-board diagnostics for vehicles less than or equal to 14,000 pounds GVWR.

Code of Federal Regulations, 2013 CFR

2013-07-01

... once per applicable certification test cycle as defined in paragraphs (a) and (d) of Appendix I of this...-based test procedures), excluding those test procedures defined as “Supplemental” test procedures in... infeasibility. Malfunctions are defined as a failure of the system or component to meet the electrical circuit...

Parent's Guide to Understanding Tests.

ERIC Educational Resources Information Center

CTB / McGraw-Hill, Monterey, CA.

This brief introduction to testing is geared to parents. Types of tests are defined, such as standardized tests, achievement tests, norm referenced tests, criterion referenced tests, and aptitude tests. Various types of scores (grade equivalent, percentile rank, and stanine are also defined, and the uses made of tests by administrators, teachers,…

Significant issues in proof testing: A critical appraisal

NASA Technical Reports Server (NTRS)

Chell, G. G.; Mcclung, R. C.; Russell, D. A.; Chang, K. J.; Donnelly, B.

1994-01-01

Issues which impact on the interpretation and quantification of proof test benefits are reviewed. The importance of each issue in contributing to the extra quality assurance conferred by proof testing components is discussed, particularly with respect to the application of advanced fracture mechanics concepts to enhance the flaw screening capability of a proof test analysis. Items covered include the role in proof testing of elastic-plastic fracture mechanics, ductile instability analysis, deterministic versus probabilistic analysis, single versus multiple cycle proof testing, and non-destructive examination (NDE). The effects of proof testing on subsequent service life are reviewed, particularly with regard to stress redistribution and changes in fracture behavior resulting from the overload. The importance of proof test conditions are also addressed, covering aspects related to test temperature, simulation of service environments, test media and the application of real-time NDE. The role of each issue in a proof test methodology is assessed with respect to its ability to: promote proof test practice to a state-of-the-art; aid optimization of proof test design; and increase awareness and understanding of outstanding issues.

40 CFR 720.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Drug, and Cosmetic Act, 21 U.S.C. 321 et seq., and the regulations issued under it. In addition, the..., 21 U.S.C. 453 et seq.; meats and meat food products, as defined in the Federal Meat Inspection Act, 21 U.S.C. 60 et seq.; and eggs and egg products, as defined in the Egg Products Inspection Act, 21 U...

40 CFR 720.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Drug, and Cosmetic Act, 21 U.S.C. 321 et seq., and the regulations issued under it. In addition, the..., 21 U.S.C. 453 et seq.; meats and meat food products, as defined in the Federal Meat Inspection Act, 21 U.S.C. 60 et seq.; and eggs and egg products, as defined in the Egg Products Inspection Act, 21 U...

17 CFR 36.3 - Exempt commercial markets.

Code of Federal Regulations, 2013 CFR

2013-04-01

... entities, as that term is defined in section 1a(17) of the Act, at the time the persons enter into the... laws; that the authorized participants are “eligible commercial entities” as defined in section 1a(17... issues that are novel, or for which compliance with a Core Principle is not self-evident, an explanation...

17 CFR 36.3 - Exempt commercial markets.

Code of Federal Regulations, 2014 CFR

2014-04-01

... entities, as that term is defined in section 1a(17) of the Act, at the time the persons enter into the... laws; that the authorized participants are “eligible commercial entities” as defined in section 1a(17... issues that are novel, or for which compliance with a Core Principle is not self-evident, an explanation...

75 FR 63382 - Financial Crimes Enforcement Network; Amendment to the Bank Secrecy Act Regulations; Defining...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

...; Amendment to the Bank Secrecy Act Regulations; Defining Mutual Funds as Financial Institutions; Extension of... those provisions in 31 CFR 103.33 that apply to mutual funds. On April 14, 2010, FinCEN issued a final rule that included mutual funds within the general definition of ``financial institution'' in...

Analyzing Media: Metaphors as Methodologies.

ERIC Educational Resources Information Center

Meyrowitz, Joshua

Students have little intuitive insight into the process of thinking and structuring ideas. The image of metaphor for a phenomenon acts as a kind of methodology for the study of the phenomenon by (1) defining the key issues or problems; (2) shaping the type of research questions that are asked; (3) defining the type of data that are searched out;…

Reflections on the Field of Higher Education: Time, Space and Sub-Fields

ERIC Educational Resources Information Center

Yokoyama, Keiko

2016-01-01

The objective of this study is to define the field of higher education and clarify its identity. It examines three analytical dimensions which, it proposes, shape the field: knowledge, approach and community. It argues that contextual knowledge around the issue of higher education has defined the field but has not determined techniques that are…

42 CFR 423.520 - Prompt payment by Part D sponsors.

Code of Federal Regulations, 2011 CFR

2011-10-01

... sponsor will issue, mail, or otherwise transmit payment with respect to all clean claims, as defined in... pharmacies) within— (i) 14 days after the date on which the claim is received, as defined in paragraph (a)(2)(i) of this section, for an electronic claim; or (ii) 30 days after the date on which the claim is...

5 CFR 9701.509 - Powers and duties of the HSLRB.

Code of Federal Regulations, 2011 CFR

2011-01-01

... arbitration awards involving the exercise of management rights, as defined in § 9701.511, and the duty to bargain, as defined in § 9701.518. The HSLRB must conduct any review of an arbitral award in accordance... security. (b) The HSLRB may issue binding Department-wide opinions, which may be appealed as if they were...

Animal experimentation.

PubMed

Kolar, Roman

2006-01-01

Millions of animals are used every year in often times extremely painful and distressing scientific procedures. Legislation of animal experimentation in modern societies is based on the supposition that this is ethically acceptable when certain more or less defined formal (e.g. logistical, technical) demands and ethical principles are met. The main parameters in this context correspond to the "3Rs" concept as defined by Russel and Burch in 1959, i.e. that all efforts to replace, reduce and refine experiments must be undertaken. The licensing of animal experiments normally requires an ethical evaluation process, often times undertaken by ethics committees. The serious problems in putting this idea into practice include inter alia unclear conditions and standards for ethical decisions, insufficient management of experiments undertaken for specific (e.g. regulatory) purposes, and conflicts of interest of ethics committees' members. There is an ongoing societal debate about ethical issues of animal use in science. Existing EU legislation on animal experimentation for cosmetics testing is an example of both the public will for setting clear limits to animal experiments and the need to further critically examine other fields and aspects of animal experimentation.

Hypervirulent (hypermucoviscous) Klebsiella pneumoniae

PubMed Central

Shon, Alyssa S.; Bajwa, Rajinder P.S.; Russo, Thomas A.

2013-01-01

A new hypervirulent (hypermucoviscous) variant of Klebsiella pneumoniae has emerged. First described in the Asian Pacific Rim, it now increasingly recognized in Western countries. Defining clinical features are the ability to cause serious, life-threatening community-acquired infection in younger healthy hosts, including liver abscess, pneumonia, meningitis and endophthalmitis and the ability to metastatically spread, an unusual feature for enteric Gram-negative bacilli in the non-immunocompromised. Despite infecting a healthier population, significant morbidity and mortality occurs. Although epidemiologic features are still being defined, colonization, particularly intestinal colonization, appears to be a critical step leading to infection. However the route of entry remains unclear. The majority of cases described to date are in Asians, raising the issue of a genetic predisposition vs. geospecific strain acquisition. The traits that enhance its virulence when compared with “classical” K. pneumoniae are the ability to more efficiently acquire iron and perhaps an increase in capsule production, which confers the hypermucoviscous phenotype. An objective diagnostic test suitable for routine use in the clinical microbiology laboratory is needed. If/when these strains become increasingly resistant to antimicrobials, we will be faced with a frightening clinical scenario. PMID:23302790

Acoustic Features Influence Musical Choices Across Multiple Genres

PubMed Central

Barone, Michael D.; Bansal, Jotthi; Woolhouse, Matthew H.

2017-01-01

Based on a large behavioral dataset of music downloads, two analyses investigate whether the acoustic features of listeners' preferred musical genres influence their choice of tracks within non-preferred, secondary musical styles. Analysis 1 identifies feature distributions for pairs of genre-defined subgroups that are distinct. Using correlation analysis, these distributions are used to test the degree of similarity between subgroups' main genres and the other music within their download collections. Analysis 2 explores the issue of main-to-secondary genre influence through the production of 10 feature-influence matrices, one per acoustic feature, in which cell values indicate the percentage change in features for genres and subgroups compared to overall population averages. In total, 10 acoustic features and 10 genre-defined subgroups are explored within the two analyses. Results strongly indicate that the acoustic features of people's main genres influence the tracks they download within non-preferred, secondary musical styles. The nature of this influence and its possible actuating mechanisms are discussed with respect to research on musical preference, personality, and statistical learning. PMID:28725200

Acute mortality in hospitalized patients undergoing echocardiography with and without an ultrasound contrast agent: results in 18,671 consecutive studies.

PubMed

Kusnetzky, Lisa L; Khalid, Adnan; Khumri, Taiyeb M; Moe, Tabitha G; Jones, Philip G; Main, Michael L

2008-04-29

We sought to define acute mortality in hospitalized patients undergoing clinically indicated echocardiography with and without use of an ultrasound contrast agent. The U.S. Food and Drug Administration recently issued a boxed warning and new contraindications for the perflutren-containing ultrasound contrast agents following post-marketing reports of 4 patient deaths that were temporally related to Definity (Bristol-Myers Squibb Medical Imaging, Billerica, Massachusetts) administration. To appreciate the incremental risk of any medical procedure, the ambient risk of untoward outcome in the population in question must first be defined. There are no published data on short-term major adverse cardiac events in hospitalized patients undergoing echocardiography, either with or without administration of an ultrasound contrast agent. A retrospective analysis of hospitalized patients undergoing clinically indicated echocardiography between January 2005 and October 2007, within Saint Luke's Health System, Kansas City, Missouri, was performed. Studies were separated into 2 groups, those performed without contrast enhancement (n = 12,475) and those performed with Definity (n = 6,196). Vital status within 24 h of the echocardiographic study was available for all patients using a combination of the Social Security Death Master File and Saint Luke's Health System medical records. Incidence of death within 24 h was compared by chi-square test between Definity and unenhanced procedures. Of the 18,671 patient events, 72 patients died within 24 h. Of those that underwent unenhanced echocardiography, 46 died within 24 h (0.37%). Of patients receiving Definity during the echocardiogram, 26 died within 24 h (0.42%). There was no statistical difference between these 2 groups (p = 0.60). No patient died within 1 h of the echocardiographic study. In a random sampling from the unenhanced (n = 201) and Definity groups (n = 202), patients who underwent Definity-enhanced echocardiography exhibited higher clinical acuity, and more significant comorbidities. Approximately 0.4% of hospitalized patients die within 24 h of echocardiography. There is no increased mortality risk associated with Definity-enhanced examinations, despite evidence for higher clinical acuity and more comorbid conditions in patients undergoing contrast studies.

Laminar-airflow equipment certification: what the pharmacist needs to know.

PubMed

Bryan, D; Marback, R C

1984-07-01

The basic information pharmacy practitioners need to determine the suitability and applicability of laminar-airflow equipment test standards and procedures is presented. The operative guideline for any laminar-flow clean bench (LFCB) certification is the cleanroom and work station requirements for controlled environments as defined by the federal government under Federal Standard 209b (FS 209b). FS 209b outlines the tests, test procedures, and acceptable performance ranges for all LFCB equipment. National Sanitation Foundation Standard Number 49 (NSF 49) is used in the certification of biological-safety cabinets (BSCs). NSF 49 covers those aspects of safety, maintenance, performance, and testing that are unique BSCs. To monitor certification properly, practitioners should be familiar with these standards and the air-velocity profile, high-efficiency particulate air filter performance, noise output, light, and electrical test procedures. A review of the requisite knowledge, experience, and reputation of certifying agents is presented, along with an outline of all the necessary procedures, equipment, and documentation to be used in the process. A thorough test report should be issued upon unit certification. As pharmacy practitioners are responsible for all other aspects of quality assurance, they should also be capable of auditing these certifications to ensure the aseptic quality of products compounded in the laminar-airflow environment.

Clinical decision making in response to performance validity test failure in a psychiatric setting.

PubMed

Marcopulos, Bernice A; Caillouet, Beth A; Bailey, Christopher M; Tussey, Chriscelyn; Kent, Julie-Ann; Frederick, Richard

2014-01-01

This study examined the clinical utility of a performance validity test (PVT) for screening consecutive referrals (N = 436) to a neuropsychology service at a state psychiatric hospital treating both civilly committed and forensic patients. We created a contingency table with Test of Memory Malingering (TOMM) pass/fail (355/81) and secondary gain present/absent (181/255) to examine pass rates associated with patient demographic, clinical and forensic status characteristics. Of the 81 failed PVTs, 48 had secondary gain defined as active criminal legal charges; 33 failed PVTs with no secondary gain. These individuals tended to be older, female, Caucasian, and civilly committed compared with the group with secondary gain who failed. From estimations of TOMM False Positive Rate and True Positive Rate we estimated base rates of neurocognitive malingering for our clinical population using the Test Validation Summary (TVS; Frederick & Bowden, 2009 ). Although PVT failure is clearly more common in a group with secondary gain (31%), there were a number of false positives (11%). Clinical ratings of patients without gain who failed suggested cognitive deficits, behavioral issues, and inattention. Low scores on PVTs in the absence of secondary gain provide useful information on test engagement and can inform clinical decisions about testing.

Genetic Counselor Practices Involving Pediatric Patients with FAP: an Investigation of their Self-Reported Strategies for Genetic Testing and Hepatoblastoma Screening.

PubMed

Lawson, Caitlin E; Attard, Thomas M; Dai, Hongying; Septer, Seth

2017-06-01

Familial adenomatous polyposis (FAP) is a cancer predisposition syndrome that causes early-onset polyposis and is associated with an increased risk for hepatoblastoma. There is currently a lack of consensus on when to order APC (adenomatous polyposis coli) gene testing or implement surveillance for hepatoblastoma. An online questionnaire was completed by 62 genetic counselors to capture their current practices regarding these questions. Extracolonic findings associated with FAP that were most likely to prompt APC testing in an otherwise asymptomatic 10 year-old child with a negative family history were multiple desmoid tumors, congenital hypertrophy of the retinal pigment epithelium (CHRPE), jaw osteomas, and hepatoblastoma. For hepatoblastoma screening, the majority did recommend this in children less than age five years with known APC mutations. An interval of every 3-6 months was most commonly suggested; however, responses extended to screening on a less than annual basis. These results highlight the need for further investigation into why some genetic counselors do not recommend APC testing in young at-risk children and what factors influence views about the ideal age and indication for APC testing. Studies of these issues would help to define the best clinical practice model for genetic testing and hepatoblastoma screening in pediatric patients with FAP.

Juvenile retinoschisis: a model for molecular diagnostic testing of X-linked ophthalmic disease.

PubMed

Sieving, P A; Yashar, B M; Ayyagari, R

1999-01-01

X-linked juvenile retinoschisis (RS) provides a starting point to define clinical paradigms and understand the limitations of diagnostic molecular testing. The RS phenotype is specific, but the broad severity range is clinically confusing. Molecular diagnostic testing obviates unnecessary examinations for boys at-risk and identifies carrier females who otherwise show no clinical signs. The XLRS1 gene has 6 exons of 26-196 base-pair size. Each exon is amplified by a single polymerase chain reaction and then sequenced, starting with exons 4 through 6, which contain mutation "hot spots." The 6 XLRS1 exons are sequenced serially. If alterations are found, they are compared with mutations in our > 120 XLRS families and with the > 300 mutations reported worldwide. Point mutations, small deletions, or rearrangements are identified in nearly 90% of males with a clinical diagnosis of RS. XLRS1 has very few sequence polymorphisms. Carrier-state testing produces 1 of 3 results: (1) positive, in which the woman has the same mutation as an affected male relative or known in other RS families; (2) negative, in which she lacks the mutation of her affected male relative; and (3) uninformative, in which no known mutation is identified or no information exists about the familial mutation. Molecular RS screening is an effective diagnostic tool that complements the clinician's skills for early detection of at-risk males. Useful outcomes of carrier testing depend on several factors: (1) a male relative with a clear clinical diagnosis; (2) a well-defined inheritance pattern; (3) high disease penetrance; (4) size and organization of the gene; and (5) the types of disease-associated mutations. Ethical questions include molecular diagnostic testing of young at-risk females before the age of consent, the impact of this information on the emotional health of the patient and family, and issues of employability and insurance coverage.

Juvenile retinoschisis: a model for molecular diagnostic testing of X-linked ophthalmic disease.

PubMed Central

Sieving, P A; Yashar, B M; Ayyagari, R

1999-01-01

BACKGROUND AND PURPOSE: X-linked juvenile retinoschisis (RS) provides a starting point to define clinical paradigms and understand the limitations of diagnostic molecular testing. The RS phenotype is specific, but the broad severity range is clinically confusing. Molecular diagnostic testing obviates unnecessary examinations for boys at-risk and identifies carrier females who otherwise show no clinical signs. METHODS: The XLRS1 gene has 6 exons of 26-196 base-pair size. Each exon is amplified by a single polymerase chain reaction and then sequenced, starting with exons 4 through 6, which contain mutation "hot spots." RESULTS: The 6 XLRS1 exons are sequenced serially. If alterations are found, they are compared with mutations in our > 120 XLRS families and with the > 300 mutations reported worldwide. Point mutations, small deletions, or rearrangements are identified in nearly 90% of males with a clinical diagnosis of RS. XLRS1 has very few sequence polymorphisms. Carrier-state testing produces 1 of 3 results: (1) positive, in which the woman has the same mutation as an affected male relative or known in other RS families; (2) negative, in which she lacks the mutation of her affected male relative; and (3) uninformative, in which no known mutation is identified or no information exists about the familial mutation. CONCLUSIONS: Molecular RS screening is an effective diagnostic tool that complements the clinician's skills for early detection of at-risk males. Useful outcomes of carrier testing depend on several factors: (1) a male relative with a clear clinical diagnosis; (2) a well-defined inheritance pattern; (3) high disease penetrance; (4) size and organization of the gene; and (5) the types of disease-associated mutations. Ethical questions include molecular diagnostic testing of young at-risk females before the age of consent, the impact of this information on the emotional health of the patient and family, and issues of employability and insurance coverage. Images FIGURE 2A FIGURE 2B PMID:10703138

Reconfiguring the Nation: Contesting History and Identity in a Globalizing World

DTIC Science & Technology

2014-09-01

Dynamical Systems Theory to investigate how ethnically, religiously and ideologically defined communities interact and coexist within and between states...investigate how ethnically religiously and ideologically defined communities interact and coexist within and between states defined on the basis of...developed as a  consequence of funding support for this project. A Special Issue of the International Journal of  Intercultural  Relations (IJIR) on

Analyzing Enterprise Networks Needs: Action Research from the Mechatronics Sector

NASA Astrophysics Data System (ADS)

Cagnazzo, Luca; Taticchi, Paolo; Bidini, Gianni; Baglieri, Enzo

New business models and theories are developing nowadays towards collaborative environments direction, and many new tools in sustaining companies involved in these organizations are emerging. Among them, a plethora of methodologies to analyze their needs are already developed for single companies. Few academic works are available about Enterprise Networks (ENs) need analysis. This paper presents the learning from an action research (AR) in the mechatronics sector: AR has been used in order to experience the issue of evaluating network needs and therefore define, develop, and test a complete framework for network evaluation. Reflection on the story in the light of the experience and the theory is presented, as well as extrapolation to a broader context and articulation of usable knowledge.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Demaria, N.

This paper is a review of recent progress of RD53 Collaboration. Results obtained on the study of the radiation effects on 65 nm CMOS have matured enough to define first strategies to adopt in the design of analog and digital circuits. Critical building blocks and analog very front end chains have been designed, tested before and after 5–800 Mrad. Small prototypes of 64×64 pixels with complex digital architectures have been produced, and point to address the main issues of dealing with extremely high pixel rates, while operating at very small in-time thresholds in the analog front end. Lastly, the collaborationmore » is now proceeding at full speed towards the design of a large scale prototype, called RD53A, in 65 nm CMOS technology.« less

Transformational leadership and moral reasoning.

PubMed

Turner, Nick; Barling, Julian; Epitropaki, Olga; Butcher, Vicky; Milner, Caroline

2002-04-01

Terms such as moral and ethical leadership are used widely in theory, yet little systematic research has related a sociomoral dimension to leadership in organizations. This study investigated whether managers' moral reasoning (n = 132) was associated with the transformational and transactional leadership behaviors they exhibited as perceived by their subordinates (n = 407). Managers completed the Defining Issues Test (J. R. Rest, 1990), whereas their subordinates completed the Multifactor Leadership Questionnaire (B. M. Bass & B. J. Avolio, 1995). Analysis of covariance indicated that managers scoring in the highest group of the moral-reasoning distribution exhibited more transformational leadership behaviors than leaders scoring in the lowest group. As expected, there was no relationship between moral-reasoning group and transactional leadership behaviors. Implications for leadership development are discussed.

A system study for the application of microcomputers to research flight test techniques

NASA Technical Reports Server (NTRS)

Smyth, R. K.

1983-01-01

The onboard simulator is a three degree of freedom aircraft behavior simulator which provides parameters used by the interception procedure. These parameters can be used for verifying closed loop performance before flight. The air to air intercept mode is a software package integrated in the simulation process that generates a target motion and performs a tracking procedure that predicts the most likely next target position, for a defined time step. This procedure also updates relative position parameters and gives adequate fire commands. A microcomputer based on an aircraft spin warning system periodically samples the assymetric thrust and yaw rate of an airplane and then issues voice synthesized warnings and /or suggests to the ilot how to respond to the situation.

UV beam shaper alignment sensitivity: grayscale versus binary designs

NASA Astrophysics Data System (ADS)

Lizotte, Todd E.

2008-08-01

What defines a good flat top beam shaper? What is more important; an ideal flat top profile or ease of alignment and stability? These are the questions designers and fabricators can not easily define, since they are a function of experience. Anyone can generate a theoretical beam shaper design and model it until it is clear that on paper the design looks good and meets the general needs of the end customer. However, the method of fabrication can add a twist that is not fully understood by either party until the beam shaper is actually tested for the first time in a system and also produced in high volume. This paper provides some insight into how grayscale and binary fabrication methods can produce the same style of beam shaper, with similar beam shaping performance; however provide a result wherein each fabricated design has separate degrees of sensitivity for alignment and stability. The paper will explain the design and fabrication approach for the two units and present alignment and testing data to provide a contrast comparison. Further data will show that over twenty sets of each fabricated design there is a consistency to the sensitivity issue. An understanding of this phenomenon is essential when considering the use of beam shapers on production equipment that is dedicated to producing micron-precision features within high value microelectronic and consumer products. We will present our findings and explore potential explanations and solutions.

The Quality of Rare Disease Registries: Evaluation and Characterization.

PubMed

Coi, Alessio; Santoro, Michele; Villaverde-Hueso, Ana; Lipucci Di Paola, Michele; Gainotti, Sabina; Taruscio, Domenica; Posada de la Paz, Manuel; Bianchi, Fabrizio

2016-01-01

The focus on the quality of the procedures for data collection, storing, and analysis in the definition and implementation of a rare disease registry (RDR) is the basis for developing a valid and long-term sustainable tool. The aim of this study was to provide useful information for characterizing a quality profile for RDRs using an analytical approach applied to RDRs participating in the European Platform for Rare Disease Registries 2011-2014 (EPIRARE) survey. An indicator of quality was defined by choosing a small set of quality-related variables derived from the survey. The random forest method was used to identify the variables best defining a quality profile for RDRs. Fisher's exact test was employed to assess the association with the indicator of quality, and the Cochran-Armitage test was used to check the presence of a linear trend along different levels of quality. The set of variables found to characterize high-quality RDRs focused on ethical and legal issues, governance, communication of activities and results, established procedures to regulate access to data and security, and established plans to ensure long-term sustainability. The quality of RDRs is usually associated with a good oversight and governance mechanism and with durable funding. The results suggest that RDRs would benefit from support in management, information technology, epidemiology, and statistics. © 2016 S. Karger AG, Basel.

Sociological Approaches to Issues on Teacher Burnout.

ERIC Educational Resources Information Center

Margolin, Edythe

Sensations of burnout have a great deal to do with societal issues and the way that society defines the self concept of individuals. When people do not feel as societal values dictate, they often begin to sense disappointment in themselves, their life styles, and what they are receiving from people around them in the form of approval, praise, or…

University Intervention into Community Issues as Dialogic Public Relations: A Case Study

ERIC Educational Resources Information Center

Byrne, Jamie M.

2007-01-01

This paper examines a study of the wastewater collection and treatment issues of Little Rock and North Little Rock, Arkansas by University of Arkansas at Little Rock personnel and how it constitutes dialogic public relations. The paper defines dialogic public relations using Kent and Taylor's work and then uses their criteria to describe how this…

Issues in the Development and Evaluation of Cross-Cultural Training in a Business Setting.

ERIC Educational Resources Information Center

Broadbooks, Wendy J.

Issues in the development and evaluation of cross-cultural training in a business setting were investigated. Cross-cultural training and cross-cultural evaluation were defined as training and evaluation of training that involve the interaction of participants from two or more different countries. Two evaluations of a management development-type…

Financial Exigency as Just Cause for Dismissal of Tenured Faculty in Higher Education: What Are the Legal Issues?

ERIC Educational Resources Information Center

Karr, Mary Beth

This paper addresses the legal issues surrounding a university or college's action of dismissing tenured faculty members because of the school's troubled financial condition or program discontinuance. It explores various legal principles through an examination of specific questions. These questions are: (1) How do the courts define financial…

26 CFR 1.1244(c)-1 - Section 1244 stock defined.

Code of Federal Regulations, 2014 CFR

2014-04-01

... November 6, 1978. (2) The term post-November 1978 stock means stock issued after November 6, 1978. In order... evidenced by a security, or arises out of the performance of personal services. (2) The following examples... subparagraph (1) of this paragraph: Example 1. A taxpayer owns stock of Corporation X issued to him prior to...

26 CFR 1.1244(c)-1 - Section 1244 stock defined.

Code of Federal Regulations, 2011 CFR

2011-04-01

... November 6, 1978. (2) The term post-November 1978 stock means stock issued after November 6, 1978. In order... evidenced by a security, or arises out of the performance of personal services. (2) The following examples... subparagraph (1) of this paragraph: Example 1. A taxpayer owns stock of Corporation X issued to him prior to...

Identity Crisis in Cormac McCarthy's "All the Pretty Horses"

ERIC Educational Resources Information Center

Gebreen, Hayder A. K.

2016-01-01

The issue of identity is one of the main issues that encounters man in each culture. Identity is a set of behaviors, emotions, and thought patterns which are unique to every individual that define him as a member of a certain group. Identity is shaped by race, ethnicity, religious beliefs, language, physical features, childhood experiences, sexual…

If We Could Plan the Next 10 Years in Science Education...

ERIC Educational Resources Information Center

Mansell, Warwick

2013-01-01

Two major sessions at the 2013 ASE Summer Celebration Conference in Hatfield offered teachers (and other educators) the chance to debate and define the key issues facing science education over the next 10 years. Participants were asked to suggest the important issues. Then those with similar proposals were put into groups to develop the idea ready…

The Golden Arches Meet the Hallowed Halls: Franchise Law and the Law School Curriculum.

ERIC Educational Resources Information Center

Wright, Danaya

1995-01-01

A law school course in franchise law focuses on how various legal issues and categories interact within the context of the narrowly defined business relationship of a franchise. Four major topics included federal and state disclosure regulations, trademarks and service marks, common law contract issues, and antitrust law. Class exercises included…

IDRA Newsletter. Volume 44, No. 1

ERIC Educational Resources Information Center

Goodman, Christie L., Ed.

2017-01-01

Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on the Promise of Public Schooling and includes: (1) America Does Not Have to Stay Stuck at Losing One in Four High Schoolers (María…

Developing Open Source Software To Advance High End Computing. Report to the President.

ERIC Educational Resources Information Center

National Coordination Office for Information Technology Research and Development, Arlington, VA.

This is part of a series of reports to the President and Congress developed by the President's Information Technology Advisory Committee (PITAC) on key contemporary issues in information technology. This report defines open source software, explains PITAC's interest in this model, describes the process used to investigate issues in open source…

Early Childhood Open-Mindedness: An Investigation into Preservice Teachers' Capacity to Address Controversial Issues

ERIC Educational Resources Information Center

Bautista, Nazan; Misco, Thomas; Quaye, Stephen John

2018-01-01

We investigated the characteristics of early childhood education (ECE) preservice teachers (PSTs) who were identified as closed minded and their capacity to deal with controversial issues. We define open-mindedness as the willingness to consider experiences, beliefs, values, and perspectives that differ from one's own. First, we used quantitative…

Issues in Designing a Hypermedia Document System: The Intermedia Case Study.

ERIC Educational Resources Information Center

Yankelovich, Nicole; And Others

1986-01-01

Intermedia, a hypermedia system developed at Brown University's Institute for Research (Rhode Island) in Information and Scholarship, is first described, and then used as a case study to explore a number of key issues that software designers must consider in the development of hypermedia document systems. A hypermedia document system is defined as…

10 CFR 13.6 - Prerequisities for issuing a complaint.

Code of Federal Regulations, 2010 CFR

2010-01-01

... amount of money, or the value of property or services, demanded or requested. [56 FR 47135, Sept. 18... time such claim is submitted (as defined in paragraph (b) of this section), the amount of money or the... complaint. (a) The reviewing official may issue a complaint under § 13.7 only if— (1) The Department of...

The Hazardous-Drums Project: A Multiweek Laboratory Exercise for General Chemistry Involving Environmental, Quality Control, and Cost Evaluation

ERIC Educational Resources Information Center

Hayes, David; Widanski, Bozena

2013-01-01

A laboratory experiment is described that introduces students to "real-world" hazardous waste management issues chemists face. The students are required to define an analytical problem, choose a laboratory analysis method, investigate cost factors, consider quality-control issues, interpret the meaning of results, and provide management…

Scaling a waterfall: a meta-ethnography of adolescent progression through the stages of HIV care in sub-Saharan Africa.

PubMed

Williams, Shannon; Renju, Jenny; Ghilardi, Ludovica; Wringe, Alison

2017-09-15

Observational studies have shown considerable attrition among adolescents living with HIV across the "cascade" of HIV care in sub-Saharan Africa, leading to higher mortality rates compared to HIV-infected adults or children. We synthesized evidence from qualitative studies on factors that promote or undermine engagement with HIV services among adolescents living with HIV in sub-Saharan Africa. We systematically searched five databases for studies published between 2005 and 2016 that met pre-defined inclusion criteria. We used a meta-ethnographic approach to identify first, second and third order constructs from eligible studies, and applied a socio-ecological framework to situate our results across different levels of influence, and in relation to each stage of the HIV cascade. We identified 3089 citations, of which 24 articles were eligible for inclusion. Of these, 17 were from Southern Africa while 11 were from Eastern Africa. 6 explored issues related to HIV testing, 11 explored treatment adherence, and 7 covered multiple stages of the cascade. Twelve third-order constructs emerged to explain adolescents' engagement in HIV care. Stigma was the most salient factor impeding adolescents' interactions with HIV care over the past decade. Self-efficacy to adapt to life with HIV and support from family or social networks were critical enablers supporting uptake and retention in HIV care and treatment programmes. Provision of adolescent-friendly services and health systems issues, such as the availability of efficient, confidential and comfortable services, were also reported to drive sustained care engagement. Individual-level factors, including past illness experiences, identifying mechanisms to manage pill-taking in social situations, financial (in)stability and the presence/absence of future aspirations also shaped adolescents HIV care engagement. Adolescents' initial and ongoing use of HIV care was frequently undermined by individual-level issues; although family, community and health systems factors played important roles. Interventions should prioritise addressing psychosocial issues among adolescents to promote individual-level engagement with HIV care, and ultimately reduce mortality. Further research should explore issues relating to care linkage and ART initiation in different settings, particularly as "test and treat" policies are scaled up.

Implementing standard setting into the Conjoint MAFP/FRACGP Part 1 examination - Process and issues.

PubMed

Chan, S C; Mohd Amin, S; Lee, T W

2016-01-01

The College of General Practitioners of Malaysia and the Royal Australian College of General Practitioners held the first Conjoint Member of the College of General Practitioners (MCGP)/Fellow of Royal Australian College of General Practitioners (FRACGP) examination in 1982, later renamed the Conjoint MAFP/FRACGP examinations. The examination assesses competency for safe independent general practice and as family medicine specialists in Malaysia. Therefore, a defensible standard set pass mark is imperative to separate the competent from the incompetent. This paper discusses the process and issues encountered in implementing standard setting to the Conjoint Part 1 examination. Critical to success in standard setting were judges' understanding of the process of the modified Angoff method, defining the borderline candidate's characteristics and the composition of judges. These were overcome by repeated hands-on training, provision of detailed guidelines and careful selection of judges. In December 2013, 16 judges successfully standard set the Part 1 Conjoint examinations, with high inter-rater reliability: Cronbach's alpha coefficient 0.926 (Applied Knowledge Test), 0.921 (Key Feature Problems).

Theoretical and methodological issues with testing the SCCT and RIASEC models: Comment on Lent, Sheu, and Brown (2010) and Lubinski (2010).

PubMed

Armstrong, Patrick Ian; Vogel, David L

2010-04-01

The current article replies to comments made by Lent, Sheu, and Brown (2010) and Lubinski (2010) regarding the study "Interpreting the Interest-Efficacy Association From a RIASEC Perspective" (Armstrong & Vogel, 2009). The comments made by Lent et al. and Lubinski highlight a number of important theoretical and methodological issues, including the process of defining and differentiating between constructs, the assumptions underlying Holland's (1959, 1997) RIASEC (Realistic, Investigative, Artistic, Social, Enterprising, and Conventional types) model and interrelations among constructs specified in social cognitive career theory (SCCT), the importance of incremental validity for evaluating constructs, and methodological considerations when quantifying interest-efficacy correlations and for comparing models using multivariate statistical methods. On the basis of these comments and previous research on the SCCT and Holland models, we highlight the importance of considering multiple theoretical perspectives in vocational research and practice. Alternative structural models are outlined for examining the role of interests, self-efficacy, learning experiences, outcome expectations, personality, and cognitive abilities in the career choice and development process. PsycINFO Database Record (c) 2010 APA, all rights reserved.

Empowerment theory: clarifying the nature of higher-order multidimensional constructs.

PubMed

Peterson, N Andrew

2014-03-01

Development of empowerment theory has focused on defining the construct at different levels of analysis, presenting new frameworks or dimensions, and explaining relationships between empowerment-related processes and outcomes. Less studied, and less conceptually developed, is the nature of empowerment as a higher-order multidimensional construct. One critical issue is whether empowerment is conceptualized as a superordinate construct (i.e., empowerment is manifested by its dimensions), an aggregate construct (i.e., empowerment is formed by its dimensions), or rather as a set of distinct constructs. To date, researchers have presented superordinate models without careful consideration of the relationships between dimensions and the higher-order construct of empowerment. Empirical studies can yield very different results, however, depending on the conceptualization of a construct. This paper represents the first attempt to address this issue systematically in empowerment theory. It is argued that superordinate models of empowerment are misspecified and research that tests alternative models at different levels of analysis is needed to advance theory, research, and practice in this area. Recommendations for future work are discussed.

Methodological challenges in using the Finnish Hospital Discharge Register for studying fire-related injuries leading to inpatient care

PubMed Central

2013-01-01

Background The objective was to examine feasibility of using hospital discharge register data for studying fire-related injuries. Methods The Finnish National Hospital Discharge Register (FHDR) was the database used to select relevant hospital discharge data to study usability and data quality issues. Patterns of E-coding were assessed, as well as prominent challenges in defining the incidence of injuries. Additionally, the issue of defining the relevant amount of hospital days accounted for in injury care was considered. Results Directly after the introduction of the ICD-10 classification system, in 1996, the completeness of E-coding was found to be poor, but to have improved dramatically around 2000 and thereafter. The scale of the challenges to defining the incidence of injuries was found to be manageable. In counting the relevant hospital days, psychiatric and long-term care were found to be the obvious and possible sources of overestimation. Conclusions The FHDR was found to be a feasible data source for studying fire-related injuries so long as potential challenges are acknowledged and taken into account. Hospital discharge data can be a unique and powerful means for injury research as issues of representativeness and coverage of traditional probability samples can frequently be completely avoided. PMID:23496937

Strength and deformability of compressed concrete elements with various types of non-metallic fiber and rods reinforcement under static loading

NASA Astrophysics Data System (ADS)

Nevskii, A. V.; Baldin, I. V.; Kudyakov, K. L.

2015-01-01

Adoption of modern building materials based on non-metallic fibers and their application in concrete structures represent one of the important issues in construction industry. This paper presents results of investigation of several types of raw materials selected: basalt fiber, carbon fiber and composite fiber rods based on glass and carbon. Preliminary testing has shown the possibility of raw materials to be effectively used in compressed concrete elements. Experimental program to define strength and deformability of compressed concrete elements with non-metallic fiber reinforcement and rod composite reinforcement included design, manufacture and testing of several types of concrete samples with different types of fiber and longitudinal rod reinforcement. The samples were tested under compressive static load. The results demonstrated that fiber reinforcement of concrete allows increasing carrying capacity of compressed concrete elements and reducing their deformability. Using composite longitudinal reinforcement instead of steel longitudinal reinforcement in compressed concrete elements insignificantly influences bearing capacity. Combined use of composite rod reinforcement and fiber reinforcement in compressed concrete elements enables to achieve maximum strength and minimum deformability.

MoMaS reactive transport benchmark using PFLOTRAN

NASA Astrophysics Data System (ADS)

Park, H.

2017-12-01

MoMaS benchmark was developed to enhance numerical simulation capability for reactive transport modeling in porous media. The benchmark was published in late September of 2009; it is not taken from a real chemical system, but realistic and numerically challenging tests. PFLOTRAN is a state-of-art massively parallel subsurface flow and reactive transport code that is being used in multiple nuclear waste repository projects at Sandia National Laboratories including Waste Isolation Pilot Plant and Used Fuel Disposition. MoMaS benchmark has three independent tests with easy, medium, and hard chemical complexity. This paper demonstrates how PFLOTRAN is applied to this benchmark exercise and shows results of the easy benchmark test case which includes mixing of aqueous components and surface complexation. Surface complexations consist of monodentate and bidentate reactions which introduces difficulty in defining selectivity coefficient if the reaction applies to a bulk reference volume. The selectivity coefficient becomes porosity dependent for bidentate reaction in heterogeneous porous media. The benchmark is solved by PFLOTRAN with minimal modification to address the issue and unit conversions were made properly to suit PFLOTRAN.

Methicillin-Resistant Staphylococcus aureus Ocular Infection in Taiwan

PubMed Central

Kang, Yu-Chuan; Hsiao, Ching-Hsi; Yeh, Lung-Kun; Ma, David H.K.; Chen, Phil Y.F.; Lin, Hsin-Chiung; Tan, Hsin-Yuan; Chen, Hung-Chi; Chen, Shin-Yi; Huang, Yhu-Chering

2015-01-01

Abstract Methicillin-resistant Staphylococcus aureus (MRSA) infection is an important public health issue. This observational study aimed to characterize clinical features, antibiotic susceptibility, and genotypes of ocular infections caused by MRSA based on the clinical and molecular definitions of community-associated (CA) and healthcare-associated (HA) strains. Fifty-nine patients with culture-proven S aureus ocular infection were enrolled from January 1, 2010 to December 31, 2011 at Chang Gung Memorial Hospital, Taiwan. Antibiotic susceptibility was verified using disk diffusion/E test. For characterization, staphylococcal cassette chromosome mec (SCCmec), pulsed-field gel electrophoresis (PFGE), multilocus sequence type (MLST), and Panton–Valentine leukocidin (PVL) gene, were performed. MRSA isolates from the patients with HA factors were classified as clinically defined HA-MRSA, and those carrying SCCmec type I to III as molecularly defined HA-MRSA. Thirty-four patients with MRSA ocular infection were identified. The most common clone of CA-MRSA and HA-MRSA isolates was ST59/PFGE type D/SCCmec IV,VT/PVL (+) (n = 12) and CC 239/PFGE type A/SCCmec III, IIIA/PVL(−) (n = 10), respectively. All the 11 patients with molecularly defined HA-MRSA infections and 50% of the 22 patients with molecularly defined CA-MRSA infections were found to have HA factors (P = .005). CA-MRSA tended to cause lid infections, whereas HA-MRSA tended to cause corneal infections. Contrary to HA-MRSA isolates, nearly all the CA-MRSA isolates were susceptible to trimethoprim/sulfamethoxazole and fluoroquinolones under either clinical or molecular classifications. In Taiwan, CA-MRSA isolates exhibited considerably higher susceptibility to fluoroquinolones when compared with HA-MRSA isolates. A strong correlation was observed between the HA factors and molecularly defined HA-MRSA isolates. PMID:26496268

Earthquake likelihood model testing

USGS Publications Warehouse

Schorlemmer, D.; Gerstenberger, M.C.; Wiemer, S.; Jackson, D.D.; Rhoades, D.A.

2007-01-01

INTRODUCTIONThe Regional Earthquake Likelihood Models (RELM) project aims to produce and evaluate alternate models of earthquake potential (probability per unit volume, magnitude, and time) for California. Based on differing assumptions, these models are produced to test the validity of their assumptions and to explore which models should be incorporated in seismic hazard and risk evaluation. Tests based on physical and geological criteria are useful but we focus on statistical methods using future earthquake catalog data only. We envision two evaluations: a test of consistency with observed data and a comparison of all pairs of models for relative consistency. Both tests are based on the likelihood method, and both are fully prospective (i.e., the models are not adjusted to fit the test data). To be tested, each model must assign a probability to any possible event within a specified region of space, time, and magnitude. For our tests the models must use a common format: earthquake rates in specified “bins” with location, magnitude, time, and focal mechanism limits.Seismology cannot yet deterministically predict individual earthquakes; however, it should seek the best possible models for forecasting earthquake occurrence. This paper describes the statistical rules of an experiment to examine and test earthquake forecasts. The primary purposes of the tests described below are to evaluate physical models for earthquakes, assure that source models used in seismic hazard and risk studies are consistent with earthquake data, and provide quantitative measures by which models can be assigned weights in a consensus model or be judged as suitable for particular regions.In this paper we develop a statistical method for testing earthquake likelihood models. A companion paper (Schorlemmer and Gerstenberger 2007, this issue) discusses the actual implementation of these tests in the framework of the RELM initiative.Statistical testing of hypotheses is a common task and a wide range of possible testing procedures exist. Jolliffe and Stephenson (2003) present different forecast verifications from atmospheric science, among them likelihood testing of probability forecasts and testing the occurrence of binary events. Testing binary events requires that for each forecasted event, the spatial, temporal and magnitude limits be given. Although major earthquakes can be considered binary events, the models within the RELM project express their forecasts on a spatial grid and in 0.1 magnitude units; thus the results are a distribution of rates over space and magnitude. These forecasts can be tested with likelihood tests.In general, likelihood tests assume a valid null hypothesis against which a given hypothesis is tested. The outcome is either a rejection of the null hypothesis in favor of the test hypothesis or a nonrejection, meaning the test hypothesis cannot outperform the null hypothesis at a given significance level. Within RELM, there is no accepted null hypothesis and thus the likelihood test needs to be expanded to allow comparable testing of equipollent hypotheses.To test models against one another, we require that forecasts are expressed in a standard format: the average rate of earthquake occurrence within pre-specified limits of hypocentral latitude, longitude, depth, magnitude, time period, and focal mechanisms. Focal mechanisms should either be described as the inclination of P-axis, declination of P-axis, and inclination of the T-axis, or as strike, dip, and rake angles. Schorlemmer and Gerstenberger (2007, this issue) designed classes of these parameters such that similar models will be tested against each other. These classes make the forecasts comparable between models. Additionally, we are limited to testing only what is precisely defined and consistently reported in earthquake catalogs. Therefore it is currently not possible to test such information as fault rupture length or area, asperity location, etc. Also, to account for data quality issues, we allow for location and magnitude uncertainties as well as the probability that an event is dependent on another event.As we mentioned above, only models with comparable forecasts can be tested against each other. Our current tests are designed to examine grid-based models. This requires that any fault-based model be adapted to a grid before testing is possible. While this is a limitation of the testing, it is an inherent difficulty in any such comparative testing. Please refer to appendix B for a statistical evaluation of the application of the Poisson hypothesis to fault-based models.The testing suite we present consists of three different tests: L-Test, N-Test, and R-Test. These tests are defined similarily to Kagan and Jackson (1995). The first two tests examine the consistency of the hypotheses with the observations while the last test compares the spatial performances of the models.

Special Issue: "Functional Dendrimers".

PubMed

Tomalia, Donald A

2016-08-09

This special issue entitled "Functional Dendrimers" focuses on the manipulation of at least six "critical nanoscale design parameters" (CNDPs) of dendrimers including: size, shape, surface chemistry, flexibility/rigidity, architecture and elemental composition. These CNDPs collectively define properties of all "functional dendrimers". This special issue contains many interesting examples describing the manipulation of certain dendrimer CNDPs to create new emerging properties and, in some cases, predictive nanoperiodic property patterns (i.e., dendritic effects). The systematic engineering of CNDPs provides a valuable strategy for optimizing functional dendrimer properties for use in specific applications.

Tracking wakefulness as it fades: Micro-measures of alertness.

PubMed

Jagannathan, Sridhar R; Ezquerro-Nassar, Alejandro; Jachs, Barbara; Pustovaya, Olga V; Bareham, Corinne A; Bekinschtein, Tristan A

2018-08-01

A major problem in psychology and physiology experiments is drowsiness: around a third of participants show decreased wakefulness despite being instructed to stay alert. In some non-visual experiments participants keep their eyes closed throughout the task, thus promoting the occurrence of such periods of varying alertness. These wakefulness changes contribute to systematic noise in data and measures of interest. To account for this omnipresent problem in data acquisition we defined criteria and code to allow researchers to detect and control for varying alertness in electroencephalography (EEG) experiments under eyes-closed settings. We first revise a visual-scoring method developed for detection and characterization of the sleep-onset process, and adapt the same for detection of alertness levels. Furthermore, we show the major issues preventing the practical use of this method, and overcome these issues by developing an automated method (micro-measures algorithm) based on frequency and sleep graphoelements, which are capable of detecting micro variations in alertness. The validity of the micro-measures algorithm was verified by training and testing using a dataset where participants are known to fall asleep. In addition, we tested generalisability by independent validation on another dataset. The methods developed constitute a unique tool to assess micro variations in levels of alertness and control trial-by-trial retrospectively or prospectively in every experiment performed with EEG in cognitive neuroscience under eyes-closed settings. Copyright © 2018. Published by Elsevier Inc.

Diagnosis and management of Silver-Russell syndrome: first international consensus statement.

PubMed

Wakeling, Emma L; Brioude, Frédéric; Lokulo-Sodipe, Oluwakemi; O'Connell, Susan M; Salem, Jennifer; Bliek, Jet; Canton, Ana P M; Chrzanowska, Krystyna H; Davies, Justin H; Dias, Renuka P; Dubern, Béatrice; Elbracht, Miriam; Giabicani, Eloise; Grimberg, Adda; Grønskov, Karen; Hokken-Koelega, Anita C S; Jorge, Alexander A; Kagami, Masayo; Linglart, Agnes; Maghnie, Mohamad; Mohnike, Klaus; Monk, David; Moore, Gudrun E; Murray, Philip G; Ogata, Tsutomu; Petit, Isabelle Oliver; Russo, Silvia; Said, Edith; Toumba, Meropi; Tümer, Zeynep; Binder, Gerhard; Eggermann, Thomas; Harbison, Madeleine D; Temple, I Karen; Mackay, Deborah J G; Netchine, Irène

2017-02-01

This Consensus Statement summarizes recommendations for clinical diagnosis, investigation and management of patients with Silver-Russell syndrome (SRS), an imprinting disorder that causes prenatal and postnatal growth retardation. Considerable overlap exists between the care of individuals born small for gestational age and those with SRS. However, many specific management issues exist and evidence from controlled trials remains limited. SRS is primarily a clinical diagnosis; however, molecular testing enables confirmation of the clinical diagnosis and defines the subtype. A 'normal' result from a molecular test does not exclude the diagnosis of SRS. The management of children with SRS requires an experienced, multidisciplinary approach. Specific issues include growth failure, severe feeding difficulties, gastrointestinal problems, hypoglycaemia, body asymmetry, scoliosis, motor and speech delay and psychosocial challenges. An early emphasis on adequate nutritional status is important, with awareness that rapid postnatal weight gain might lead to subsequent increased risk of metabolic disorders. The benefits of treating patients with SRS with growth hormone include improved body composition, motor development and appetite, reduced risk of hypoglycaemia and increased height. Clinicians should be aware of possible premature adrenarche, fairly early and rapid central puberty and insulin resistance. Treatment with gonadotropin-releasing hormone analogues can delay progression of central puberty and preserve adult height potential. Long-term follow up is essential to determine the natural history and optimal management in adulthood.

Estimating influenza vaccine effectiveness: Evolution of methods to better understand effects of confounding in older adults.

PubMed

McElhaney, Janet E; Andrew, Melissa K; McNeil, Shelly A

2017-11-01

Older adults are at high risk for serious complications of influenza illness and loss of vaccine-mediated protection. It is increasingly recognized that in addition to age, multiple chronic conditions and associated frailty contribute to the decline in vaccine effectiveness in this population. However, observational studies have been fraught with issues of confounding related to the degree of frailty and functional decline, measures of which are not included in standard administrative health care databases that are used to calculate vaccine effectiveness. This issue has led to the identification of confounding by indication or from "healthy vaccinee" bias, which respectively lead to underestimates or overestimates of influenza vaccine effectiveness. In addition, the sensitivity and specificity of the criteria used to define influenza-like illness declines with increasing age due to atypical presentations of illness and the inability to distinguish between influenza and other respiratory viruses. The test-negative case:control design has emerged as a method to estimate influenza vaccine effectiveness by comparing vaccination rates in those with laboratory-confirmed influenza to those with other acute viral respiratory illnesses. This review provides a perspective on how test-negative case:control study designs and new insights into mechanisms of protection have considerably strengthened influenza vaccination policy decisions for older adults that have historically been undermined by the conclusions of observational studies. Copyright © 2017 Elsevier Ltd. All rights reserved.

Validation of cell-based fluorescence assays: practice guidelines from the ICSH and ICCS - part IV - postanalytic considerations.

PubMed

Barnett, David; Louzao, Raaul; Gambell, Peter; De, Jitakshi; Oldaker, Teri; Hanson, Curtis A

2013-01-01

Flow cytometry and other technologies of cell-based fluorescence assays are as a matter of good laboratory practice required to validate all assays, which when in clinical practice may pass through regulatory review processes using criteria often defined with a soluble analyte in plasma or serum samples in mind. Recently the U.S. Food and Drug Administration (FDA) has entered into a public dialogue in the U.S. regarding their regulatory interest in laboratory developed tests (LDTs) or so-called home brew assays performed in clinical laboratories. The absence of well-defined guidelines for validation of cell-based assays using fluorescence detection has thus become a subject of concern for the International Council for Standardization of Haematology (ICSH) and International Clinical Cytometry Society (ICCS). Accordingly, a group of over 40 international experts in the areas of test development, test validation, and clinical practice of a variety of assay types using flow cytometry and/or morphologic image analysis were invited to develop a set of practical guidelines useful to in vitro diagnostic (IVD) innovators, clinical laboratories, regulatory scientists, and laboratory inspectors. The focus of the group was restricted to fluorescence reporter reagents, although some common principles are shared by immunohistochemistry or immunocytochemistry techniques and noted where appropriate. The work product of this two year effort is the content of this special issue of this journal, which is published as 5 separate articles, this being Validation of Cell-based Fluorescence Assays: Practice Guidelines from the ICSH and ICCS - Part IV - Postanalytic considerations. © 2013 International Clinical Cytometry Society.

Cognitive software defined radar: waveform design for clutter and interference suppression

NASA Astrophysics Data System (ADS)

Kirk, Benjamin H.; Owen, Jonathan W.; Narayanan, Ram M.; Blunt, Shannon D.; Martone, Anthony F.; Sherbondy, Kelly D.

2017-05-01

Clutter and radio frequency interference (RFI) are prevalent issues in the field of radar and are specifically of interest to of cognitive radar. Here, methods for applying and testing the utility of cognitive radar for clutter and RFI mitigation are explored. Using the adaptable transmit capability, environmental database, and general "awareness" of a cognitive radar system (i.e. spectrum sensing, geographical location, etc.), a matched waveform is synthesized that improves the signal-to-clutter ratio (SCR), assuming at least an estimate of the target response and the environmental clutter response are known a prior i. RFI may also be mitigated by sensing the RF spectrum and adapting the transmit center frequency and bandwidth using methods that optimize bandwidth and signal-to-interference plus noise ratio (SINR) (i.e. the spectrum sensing, multi-objective (SS-MO) algorithm). The improvement is shown by a decrease in the noise floor. The above methods' effectiveness are examined via a test-bed developed around a software defined radio (SDR). Testing and the general use of commercial off the shelf (COTS) devices are desirable for their cost effectiveness, general ease of use, as well as technical and community support, but these devices provide design challenges in order to be effective. The universal software radio peripheral (USRP) X310 SDR is a relatively cheap and portable device that has all the system components of a basic cognitive radar. Design challenges of the SDR include phase coherency between channels, bandwidth limitations, dynamic range, and speed of computation and data communication / recording.

Workplace Issues: Testing, Training and Policy.

ERIC Educational Resources Information Center

Feuer, Dale

1987-01-01

Presents information on organizations with over 50 employees concerning such workplace issues as drug testing, Acquired Immune Deficiency Syndrome testing, and policies on these issues and on smoking, sexual harassment, and affirmative action. Results are broken down by company size and by industry. (CH)

Top-Down Modulation on Perceptual Decision with Balanced Inhibition through Feedforward and Feedback Inhibitory Neurons

PubMed Central

Wang, Cheng-Te; Lee, Chung-Ting; Wang, Xiao-Jing; Lo, Chung-Chuan

2013-01-01

Recent physiological studies have shown that neurons in various regions of the central nervous systems continuously receive noisy excitatory and inhibitory synaptic inputs in a balanced and covaried fashion. While this balanced synaptic input (BSI) is typically described in terms of maintaining the stability of neural circuits, a number of experimental and theoretical studies have suggested that BSI plays a proactive role in brain functions such as top-down modulation for executive control. Two issues have remained unclear in this picture. First, given the noisy nature of neuronal activities in neural circuits, how do the modulatory effects change if the top-down control implements BSI with different ratios between inhibition and excitation? Second, how is a top-down BSI realized via only excitatory long-range projections in the neocortex? To address the first issue, we systematically tested how the inhibition/excitation ratio affects the accuracy and reaction times of a spiking neural circuit model of perceptual decision. We defined an energy function to characterize the network dynamics, and found that different ratios modulate the energy function of the circuit differently and form two distinct functional modes. To address the second issue, we tested BSI with long-distance projection to inhibitory neurons that are either feedforward or feedback, depending on whether these inhibitory neurons do or do not receive inputs from local excitatory cells, respectively. We found that BSI occurs in both cases. Furthermore, when relying on feedback inhibitory neurons, through the recurrent interactions inside the circuit, BSI dynamically and automatically speeds up the decision by gradually reducing its inhibitory component in the course of a trial when a decision process takes too long. PMID:23626812

Top-down modulation on perceptual decision with balanced inhibition through feedforward and feedback inhibitory neurons.

PubMed

Wang, Cheng-Te; Lee, Chung-Ting; Wang, Xiao-Jing; Lo, Chung-Chuan

2013-01-01

Recent physiological studies have shown that neurons in various regions of the central nervous systems continuously receive noisy excitatory and inhibitory synaptic inputs in a balanced and covaried fashion. While this balanced synaptic input (BSI) is typically described in terms of maintaining the stability of neural circuits, a number of experimental and theoretical studies have suggested that BSI plays a proactive role in brain functions such as top-down modulation for executive control. Two issues have remained unclear in this picture. First, given the noisy nature of neuronal activities in neural circuits, how do the modulatory effects change if the top-down control implements BSI with different ratios between inhibition and excitation? Second, how is a top-down BSI realized via only excitatory long-range projections in the neocortex? To address the first issue, we systematically tested how the inhibition/excitation ratio affects the accuracy and reaction times of a spiking neural circuit model of perceptual decision. We defined an energy function to characterize the network dynamics, and found that different ratios modulate the energy function of the circuit differently and form two distinct functional modes. To address the second issue, we tested BSI with long-distance projection to inhibitory neurons that are either feedforward or feedback, depending on whether these inhibitory neurons do or do not receive inputs from local excitatory cells, respectively. We found that BSI occurs in both cases. Furthermore, when relying on feedback inhibitory neurons, through the recurrent interactions inside the circuit, BSI dynamically and automatically speeds up the decision by gradually reducing its inhibitory component in the course of a trial when a decision process takes too long.

Issues associated with the emergence of coeliac disease in the Asia–Pacific region: a working party report of the World Gastroenterology Organization and the Asian Pacific Association of Gastroenterology.

PubMed

Makharia, Govind K; Mulder, Chris J J; Goh, Khean Lee; Ahuja, Vineet; Bai, Julio C; Catassi, Carlo; Green, Peter H R; Gupta, Siddhartha Datta; Lundin, Knut E A; Ramakrishna, Balakrishnan Siddartha; Rawat, Ramakant; Sharma, Hanish; Sood, Ajit; Watanabe, Chikako; Gibson, Peter R

2014-04-01

Once thought to be uncommon in Asia, coeliac disease (CD) is now being increasingly recognized in Asia–Pacific region. In many Asian nations, CD is still considered to be either nonexistent or very rare. In recognition of such heterogeneity of knowledge and awareness, the World Gastroenterology Organization and the Asian Pacific Association of Gastroenterology commissioned a working party to address the key issues in emergence of CD in Asia. A working group consisting of members from Asia–Pacific region, Europe, North America, and South America reviewed relevant existing literature with focus on those issues specific to Asia–Pacific region both in terms of what exists and what needs to be done. The working group identified the gaps in epidemiology, diagnosis, and management of CD in Asian–Pacific region and recommended the following: to establish prevalence of CD across region, increase in awareness about CD among physicians and patients, and recognition of atypical manifestations of CD. The challenges such as variability in performance of serological tests, lack of population-specific cut-offs values for a positive test, need for expert dietitians for proper counseling and supervision of patients, need for gluten-free infrastructure in food supply and creation of patient advocacy organizations were also emphasized. Although absolute number of patients with CD at present is not very large, this number is expected to increase over the next few years or decades. It is thus appropriate that medical community across the Asia–Pacific region define extent of problem and get prepared to handle impending epidemic of CD.

Semi-Automated Air-Coupled Impact-Echo Method for Large-Scale Parkade Structure.

PubMed

Epp, Tyler; Svecova, Dagmar; Cha, Young-Jin

2018-03-29

Structural Health Monitoring (SHM) has moved to data-dense systems, utilizing numerous sensor types to monitor infrastructure, such as bridges and dams, more regularly. One of the issues faced in this endeavour is the scale of the inspected structures and the time it takes to carry out testing. Installing automated systems that can provide measurements in a timely manner is one way of overcoming these obstacles. This study proposes an Artificial Neural Network (ANN) application that determines intact and damaged locations from a small training sample of impact-echo data, using air-coupled microphones from a reinforced concrete beam in lab conditions and data collected from a field experiment in a parking garage. The impact-echo testing in the field is carried out in a semi-autonomous manner to expedite the front end of the in situ damage detection testing. The use of an ANN removes the need for a user-defined cutoff value for the classification of intact and damaged locations when a least-square distance approach is used. It is postulated that this may contribute significantly to testing time reduction when monitoring large-scale civil Reinforced Concrete (RC) structures.

Semi-Automated Air-Coupled Impact-Echo Method for Large-Scale Parkade Structure

PubMed Central

Epp, Tyler; Svecova, Dagmar; Cha, Young-Jin

2018-01-01

Structural Health Monitoring (SHM) has moved to data-dense systems, utilizing numerous sensor types to monitor infrastructure, such as bridges and dams, more regularly. One of the issues faced in this endeavour is the scale of the inspected structures and the time it takes to carry out testing. Installing automated systems that can provide measurements in a timely manner is one way of overcoming these obstacles. This study proposes an Artificial Neural Network (ANN) application that determines intact and damaged locations from a small training sample of impact-echo data, using air-coupled microphones from a reinforced concrete beam in lab conditions and data collected from a field experiment in a parking garage. The impact-echo testing in the field is carried out in a semi-autonomous manner to expedite the front end of the in situ damage detection testing. The use of an ANN removes the need for a user-defined cutoff value for the classification of intact and damaged locations when a least-square distance approach is used. It is postulated that this may contribute significantly to testing time reduction when monitoring large-scale civil Reinforced Concrete (RC) structures. PMID:29596332

Rationality, practice variation and person‐centred health policy: a threshold hypothesis

PubMed Central

Hamm, Robert M.; Mayrhofer, Thomas; Hozo, Iztok; Van den Ende, Jef

2015-01-01

Abstract Variation in practice of medicine is one of the major health policy issues of today. Ultimately, it is related to physicians' decision making. Similar patients with similar likelihood of having disease are often managed by different doctors differently: some doctors may elect to observe the patient, others decide to act based on diagnostic testing and yet others may elect to treat without testing. We explain these differences in practice by differences in disease probability thresholds at which physicians decide to act: contextual social and clinical factors and emotions such as regret affect the threshold by influencing the way doctors integrate objective data related to treatment and testing. However, depending on a theoretical construct each of the physician's behaviour can be considered rational. In fact, we showed that the current regulatory policies lead to predictably low thresholds for most decisions in contemporary practice. As a result, we may expect continuing motivation for overuse of treatment and diagnostic tests. We argue that rationality should take into account both formal principles of rationality and human intuitions about good decisions along the lines of Rawls' ‘reflective equilibrium/considered judgment’. In turn, this can help define a threshold model that is empirically testable. PMID:26639018

How to prevent overdiagnosis.

PubMed

Chiolero, Arnaud; Paccaud, Fred; Aujesky, Drahomir; Santschi, Valérie; Rodondi, Nicolas

2015-01-01

Overdiagnosis is the diagnosis of an abnormality that is not associated with a substantial health hazard and that patients have no benefit to be aware of. It is neither a misdiagnosis (diagnostic error), nor a false positive result (positive test in the absence of a real abnormality). It mainly results from screening, use of increasingly sensitive diagnostic tests, incidental findings on routine examinations, and widening diagnostic criteria to define a condition requiring an intervention. The blurring boundaries between risk and disease, physicians' fear of missing a diagnosis and patients' need for reassurance are further causes of overdiagnosis. Overdiagnosis often implies procedures to confirm or exclude the presence of the condition and is by definition associated with useless treatments and interventions, generating harm and costs without any benefit. Overdiagnosis also diverts healthcare professionals from caring about other health issues. Preventing overdiagnosis requires increasing awareness of healthcare professionals and patients about its occurrence, the avoidance of unnecessary and untargeted diagnostic tests, and the avoidance of screening without demonstrated benefits. Furthermore, accounting systematically for the harms and benefits of screening and diagnostic tests and determining risk factor thresholds based on the expected absolute risk reduction would also help prevent overdiagnosis.

Non-Destructive Thermography Analysis of Impact Damage on Large-Scale CFRP Automotive Parts.

PubMed

Maier, Alexander; Schmidt, Roland; Oswald-Tranta, Beate; Schledjewski, Ralf

2014-01-14

Laminated composites are increasingly used in aeronautics and the wind energy industry, as well as in the automotive industry. In these applications, the construction and processing need to fulfill the highest requirements regarding weight and mechanical properties. Environmental issues, like fuel consumption and CO₂-footprint, set new challenges in producing lightweight parts that meet the highly monitored standards for these branches. In the automotive industry, one main aspect of construction is the impact behavior of structural parts. To verify the quality of parts made from composite materials with little effort, cost and time, non-destructive test methods are increasingly used. A highly recommended non-destructive testing method is thermography analysis. In this work, a prototype for a car's base plate was produced by using vacuum infusion. For research work, testing specimens were produced with the same multi-layer build up as the prototypes. These specimens were charged with defined loads in impact tests to simulate the effect of stone chips. Afterwards, the impacted specimens were investigated with thermography analysis. The research results in that work will help to understand the possible fields of application and the usage of thermography analysis as the first quick and economic failure detection method for automotive parts.

Pharmacoeconomics--an aid to better decision-making.

PubMed

Arenas-Guzman, R; Tosti, A; Hay, R; Haneke, E

2005-09-01

The first aim of this workshop was to define pharmacoeconomic concepts and terminology. Pharmacoeconomics can be defined as the branch of economics that uses cost-benefit, cost-effectiveness, cost-minimization, cost-of-illness and cost-utility analyses to compare pharmaceutical products and treatment strategies. Economic evaluations provide healthcare decision-makers with valuable information, allowing optimal allocation of limited resources. However, pharmacoeconomics is based on long-term benefits, whereas physicians are typically forced to seek immediate savings. The second aim was to review pharmacoeconomic studies in the field of onychomycosis and finally to discuss future perspectives. We discussed current pharmacoeconomic issues on the management of onychomycosis. Consensus was reached on the following issues: * Published pharmacoeconomic studies concerning onychomycosis are flawed. Future studies should be based on internationally validated principles and appropriate models. The fact that costs of different drugs, laboratory examinations and physician visits vary worldwide should be considered. Cost-benefit studies are required. * The National Institute for Clinical Excellence (NICE) recommendations are often considered in countries other than the UK, even when not adapted to the country in question. * Generic drugs might reduce costs, but this depends on their effectiveness (bioavailability). * Sampling requests affect the economic cost (dependent on methodology, which depends on country) and physicians often trust their instincts even when tests are repeatedly negative. * The cost of adverse event management is usually considered to be 10%; this may be too high for onychomycosis, as treatments are relatively safe without severe side-effects. * Probability of recurrence for each drug should be determined. * Need for disease severity standardization, definition of diagnostic criteria and successful treatment (mycological and clinical cure).

Ares I-X Roll Control System Development

NASA Technical Reports Server (NTRS)

Unger, Ronald J.; Massey, Edmund C.

2009-01-01

Project Managers often face challenging technical, schedule and budget issues. This presentation will explore how the Ares I-X Roll Control System Integrated Product Team (IPT) mitigated challenges such as concurrent engineering requirements and environments and evolving program processes, while successfully managing an aggressive project schedule and tight budget. IPT challenges also included communications and negotiations among inter- and intra-government agencies, including the US Air Force, NASA/MSFC Propulsion Engineering, LaRC, GRC, KSC, WSTF, and the Constellation Program. In order to successfully meet these challenges it was essential that the IPT define those items that most affected the schedule critical path, define early mitigation strategies to reduce technical, schedule, and budget risks, and maintain the end-product focus of an "unmanned test flight" context for the flight hardware. The makeup of the IPT and how it would function were also important considerations. The IPT consisted of NASA/MSFC (project management, engineering, and safety/quality) and contractors (Teledyne Brown Engineering and Pratt and Whitney Rocketdyne, who supplied heritage hardware experience). The early decision to have a small focused IPT working "badgelessly" across functional lines to eliminate functional stove-piping allowed for many more tasks to be done by fewer people. It also enhanced a sense of ownership of the products, while still being able to revert back to traditional roles in order to provide the required technical independence in design reviews and verification closures. This presentation will highlight several prominent issues and discuss how they were mitigated and the resulting Lessons Learned that might benefit other projects.

Using pressure transient analysis to improve well performance and optimize field development in compartmentalized shelf margin deltaic reservoirs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Badgett, K.L.; Crawford, G.E.; Mills, W.H.

1996-12-31

BP Exploration`s Gulf of Mexico group developed procedures to conduct effective well tests on conventional production wells and employed them during the development drilling phase of the Mississippi Canyon 109 (MC109) field. Bottomhole pressure data were recorded during the initial few weeks of production. Typically, a 48 hour pressure buildup survey (surface shut-in) was obtained near the end of data acquisition. Data from these tests were analyzed for completion efficiency, reservoir flow capacity, reservoir heterogeneities, and drainage area. Initially wells were gravel packed for sand control, until buildup interpretations indicated skins greater than 20. Frac packing technology was then employed,more » and an immediate improvement was observed with skins dropping into the teens. Over a period of time frac packs were optimized using the test derived skins as a metric. Analysis of pressure data also played an important role in identifying reservoir compartmentalization. The two major reservoir horizons at MC 109 are interpreted as shelf margin deltas. However, each of these has distinctly different compartmentalization issues. The continuous character of the G Sand made it easier to define the depositional system and investigate reservoir compartmentalization issues using a combination of well log, 3D seismic, static pressure trends, and fluid information. In the more distal deltaic reservoirs of the J Sand however, complications with seismic amplitudes and a less reliable tie between wireline and seismic data required the use of pressure transient analysis to efficiently exploit the reservoir.« less

Historical development of limits of acceptable change: conceptual clarifications and possible extensions

Treesearch

David N. Cole; George H. Stankey

1997-01-01

The Limits of Acceptable Change (LAC) process was developed to deal with the issue of recreational carrying capacity. For that purpose, the LAC process sought to explicitly define a compromise between resource/visitor experience protection and recreation use goals. The most critical and unique element of the process is the specification of LAC standards that define...

Focal Uncaging of GABA Reveals a Temporally Defined Role for GABAergic Inhibition during Appetitive Associative Olfactory Conditioning in Honeybees

ERIC Educational Resources Information Center

Raccuglia, Davide; Mueller, Uli

2013-01-01

Throughout the animal kingdom, the inhibitory neurotransmitter ?-aminobutyric acid (GABA) is a key modulator of physiological processes including learning. With respect to associative learning, the exact time in which GABA interferes with the molecular events of learning has not yet been clearly defined. To address this issue, we used two…

A Defining Time for Physical Education Futures? Exploring the Legacy of Fritz Duras

ERIC Educational Resources Information Center

Kirk, David

2014-01-01

This paper explores the legacy of Dr Fritz Duras in order to address the issue of whether the implementation of a new curriculum for health and physical education in Australia represents a defining time for the subject. Dr Duras was Director of the first physical education teacher education course at the University of Melbourne during an earlier…

Review of the Research Literature on Defining and Demonstrating Quality Teaching and Impact in Higher Education

ERIC Educational Resources Information Center

Strang, Lucy; Bélanger, Julie; Manville, Catriona; Meads, Catherine

2016-01-01

In March 2016, the Higher Education Academy (HEA) commissioned RAND Europe to conduct a literature review of research published since 2012, with the aim of identifying and summarising the key trends and issues in the literature on how "quality teaching" and its impact are currently being defined and demonstrated at higher education…

Research in geosciences policy

NASA Technical Reports Server (NTRS)

Brunner, Ronald D.

1992-01-01

The general task was to look beyond the adverse physical impacts and to defining the policy problem. In order for policy actions to be effective, they must address the right policy problems, which will be different from and broader than the physical problems. We will work on defining the policy problems with a view to indicating how practical solutions might be implemented. In particular, public officials need advice on what should be said, and done, and for what purposes. That advice needs to be based on systematic analysis of: (1) the scholarly literature in the social sciences, and related disciplines; (2) the charging content of the policy debate at the center of attention; and (3) how citizens perceive and understand issues related to global change. We will conduct this analysis. Chapter 1 and 2 each reports work on defining the policy problem and analyzing the scholarly literature. Chapters 3 and 4, respectively, address the policy debate and citizen viewpoints in issues related to global change.

Public consultation in ethics: an experiment in representative ethics.

PubMed

Burgess, Michael M

2004-01-01

Genome Canada has funded a research project to evaluate the usefulness of different forms of ethical analysis for assessing the moral weight of public opinion in the governance of genomics. This paper will describe a role of public consultation for ethical analysis and a contribution of ethical analysis to public consultation and the governance of genomics/biotechnology. Public consultation increases the robustness of ethical analysis with a more diverse set of moral experiences. Consultation must be carefully and respectfully designed to generate sufficiently diverse and rich accounts of moral experiences. Since dominant groups tend to define ethical or policy issues in a manner that excludes some interests or perspectives, it is important to identify the range of interests that diverse publics hold before defining the issue and scope of the discussion and the premature foreclosure of ethical dialogue. Consequently, a significant contribution of ethical dialogue strengthened by social analysis is to consider the context and non-policy use of power to govern genomics and to sustain social debate on enduring ethical issues.