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  1. RELACIÓN MÉDICO PACIENTE: DERECHOS DEL ADULTO MAYOR

    PubMed Central

    Barrantes-Monge, Melba; Rodríguez, Eduardo; Lama, Alexis

    2009-01-01

    Existen prejuicios en relación con la vejez, incluso entre los profesionales que se dedican a la gerontología. Uno común y peligroso es considerar que los viejos son todos enfermos o discapacitados. La relación médico-paciente es la piedra angular de la práctica y ética médicas. Para alcanzar el respeto por los adultos mayores es necesaria una medicina prudente, basada en una práctica en la cual la reflexión ética y clínica pueda contribuir. Esto último es posible si se hacen valer los derechos del adulto mayor, en particular como paciente para la toma de decisiones. PMID:20379380

  2. Fusarium sambucinum astA gene expressed during potato infection is a functional orthologue of Aspergillus nidulans astA.

    PubMed

    Piłsyk, Sebastian; Natorff, Renata; Gawińska-Urbanowicz, Hanna; Kruszewska, Joanna S

    2015-06-01

    Sulfate assimilation plays a vital role in prototrophic organisms. Orthologues of the alternative sulfate transporter (AstA) gene from Aspergillus nidulans were identified in the fungal plant pathogens Fusarium sambucinum and Fusarium graminearum. By physiological and biochemical analyses, the AstA orthologues were determined to be able to uptake sulfate from the environment. Similarly to astA in A. nidulans, the FsastA gene was found to be regulated by sulfur metabolite repression (SMR) in a sulfur-dependent manner. In contrast, the FgastA transcript was undetectable, however, when the FgastA gene was expressed heterologously in A. nidulans, the translated FgAstA protein acted as a sulfate transporter. Interestingly, F. sambucinum astA expression was remarkably augmented in infected potato tubers, despite the presence abundant sulfate and was found not to be correlated with plant resistance.

  3. Fusarium sambucinum astA gene expressed during potato infection is a functional orthologue of Aspergillus nidulans astA.

    PubMed

    Piłsyk, Sebastian; Natorff, Renata; Gawińska-Urbanowicz, Hanna; Kruszewska, Joanna S

    2015-06-01

    Sulfate assimilation plays a vital role in prototrophic organisms. Orthologues of the alternative sulfate transporter (AstA) gene from Aspergillus nidulans were identified in the fungal plant pathogens Fusarium sambucinum and Fusarium graminearum. By physiological and biochemical analyses, the AstA orthologues were determined to be able to uptake sulfate from the environment. Similarly to astA in A. nidulans, the FsastA gene was found to be regulated by sulfur metabolite repression (SMR) in a sulfur-dependent manner. In contrast, the FgastA transcript was undetectable, however, when the FgastA gene was expressed heterologously in A. nidulans, the translated FgAstA protein acted as a sulfate transporter. Interestingly, F. sambucinum astA expression was remarkably augmented in infected potato tubers, despite the presence abundant sulfate and was found not to be correlated with plant resistance. PMID:25986548

  4. Channeling Radiation Experiment at Fermilab ASTA

    SciTech Connect

    Mihalcea, D.; Edstrom, D. R.; Piot, P.; Rush, W.; Sen, T.

    2015-06-01

    Electron beams with moderate energy ranging from 4 to 50 MeV can be used to produce x-rays through the Channeling Radiation (CR) mechanism. Typically, the xray spectrum from these sources extends up to 140 keV and this range covers the demand for most practical applications. The parameters of the electron beam determine the spectral brilliance of the x-ray source. The electron beam produced at the Fermilab new facility Advanced Superconducting Test Accelerator (ASTA) meets the requirements to assemble an experimental high brilliance CR xray source. In the first stage of the experiment the energy of the beam is 20 MeV and due to the very low emittance ($\\approx 100$ nm ) at low bunch charge (20 pC) the expected average brilliance of the x-ray source is about $10^9$ photons/[s- $(mm-mrad)^2$-0.1% BW]. In the second stage of the experiment the beam energy will be increased to 50 MeV and consequently the average brilliance will increase by a factor of five. Also, the x-ray spectrum will extend from about 30 keV to 140 keV

  5. A Global Approach to STEM Education: ASTA Science Teachers Exchange--Japan 2015

    ERIC Educational Resources Information Center

    Teaching Science, 2015

    2015-01-01

    The new Australian Curriculum includes among its three cross-curriculum priorities a focus on Asia and Australia's engagement with Asia. The Australian Science Teachers Association (ASTA)'s Science Teachers Exchange--JAPAN program provides teachers with direct, personal insight into one of Australia's key Asian neighbours.

  6. Spectral brilliance of channeling radiation at the ASTA photoinjector

    DOE PAGESBeta

    Sen, Tanaji; Lynn, Christopher

    2014-12-01

    We study channeling radiation from electron beams with energies under 100 MeV. We introduce a phenomenological model of dechanneling, correct nonradiative transition rates from thermal scattering, and discuss in detail the population dynamics in low-order bound states. These are used to revisit the X-ray properties measured at the ELBE facility in Forschungszentrum Dresden–Rosenstock (FZDR), extract parameters for dechanneling states, and obtain satisfactory agreement with measured photon yields. The importance of rechanneling phenomena in thick crystals is emphasized. The model is then used to calculate the expected X-ray energies, linewidths and brilliance for forthcoming channeling radiation experiments at Fermilab's ASTA photoinjector.

  7. Mitigation Plans for the Microbunching-Instability-Related COTR at ASTA/FNAL

    SciTech Connect

    Lumpkin, A. H.; Johnson, A. M.

    2013-05-01

    At the Advanced Superconducting Test Accelerator (ASTA) now under construction at Fermilab, we anticipate the appearance of the microbunching instability related to the longitudinal space charge (LSC) impedances. With a photoinjector source and up to two chicane compressors planned, the conditions should result in the shift of some microbunched features into the visible light regime. The presence of longitudinal microstructures (microbunching) in the electron beam or the leading edge spikes can result in strong, spatially localized coherent enhancements of optical transition radiation (COTR) that mask the actual beam profile. Several efforts on mitigation of the effects in the diagnostics task have been identified. At ASTA we have designed the beam profiling stations to have mitigation features based on spectral filtering, scintillator choice, and the timing of the trigger to the digital camera's CCD chip. Since the COTR is more intense in the NIR than UV we have selectable bandpass filters centered at 420 nm which also overlap the spectral emissions of the LYSO:Ce scintillators. By delaying the CCD trigger timing of the integration window by 40-50 ns, we can reject the prompt OTR signal and integrate on the delayed scintillator light predominately. This combination of options should allow mitigation of COTR enhancements of order 100-1000 in the distribution.

  8. Development and validation of a new Arrhythmia-Specific questionnaire in Tachycardia and Arrhythmia (ASTA) with focus on symptom burden

    PubMed Central

    2012-01-01

    Background Arrhythmias can appear with a variety of symptoms, all from vague to pronounced and handicapping symptoms. Therefore, patient-reported outcomes (PROs) concerning symptom burden are important to assess and take into consideration in the care and treatment of patients with arrhythmias. The main purpose was to develop and validate a disease-specific questionnaire evaluating symptom burden in patients with different forms of arrhythmias. Methods A literature review was conducted and arrhythmia patients were interviewed. Identified symptoms were evaluated by an expert panel consisting of cardiologists and nurses working daily with arrhythmia patients. SF-36 and Symptoms Checklist (SCL) were used in the validation of the new questionnaire Arrhythmia-Specific questionnaire in Tachycardia and Arrhythmia (ASTA). Homogeneity was evaluated with Spearman´s correlations and Cronbach´s alpha coefficient (α) was used to evaluate internal consistency. Construct validity was evaluated using item-total correlations and convergent and discriminant validity. For this, Spearman´s correlations were calculated between the ASTA symptom scale, SCL and SF-36. Concurrent validity was validated by Spearman´s correlations between the ASTA symptom scale and SCL. Results The correlations between the different items in the ASTA symptom scale showed generally sufficient homogeneity. Cronbach´s coefficient was found to be satisfactory (α = 0.80; lower bound 95 % CI for α = 0.76). Construct validity was supported by item-total correlations where all items in the symptom scale were sufficiently correlated (≥0.3). Convergent and discriminant validity was supported by the higher correlations to the arrhythmia-specific SCL compared to the generic SF-36. Concurrent validity was evaluated and there were sufficiently, but not extremely strong correlations found between the ASTA symptom scale and SCL. Conclusions The nine items of the ASTA symptom scale were found to have good

  9. Tell It to the Mayor

    ERIC Educational Resources Information Center

    Schachter, Ron

    2009-01-01

    Mayoral control of public schools is nothing new. Boston pioneered the practice in 1992, replacing elected school committee members with mayoral appointees. Since then, a dozen urban districts--including Cleveland, Chicago, New York City, and Washington, D.C.--have undergone a similar change in school governance that has shifted some or most of…

  10. Mechanical Design of a High Energy Beam Absorber for the Advanced Superconducting Test Accelerator (ASTA) at Fermilab

    SciTech Connect

    Baffes, C.; Church, M.; Leibfritz, J.; Oplt, S.; Rakhno, I.; /Fermilab

    2012-05-10

    A high energy beam absorber has been built for the Advanced Superconducting Test Accelerator (ASTA) at Fermilab. In the facility's initial configuration, an electron beam will be accelerated through 3 TTF-type or ILC-type SRF cryomodules to an energy of 750MeV. The electron beam will be directed to one of multiple downstream experimental and diagnostic beam lines and then deposited in one of two beam absorbers. The facility is designed to accommodate up to 6 cryomodules, which would produce a 75kW beam at 1.5GeV; this is the driving design condition for the beam absorbers. The beam absorbers consist of water-cooled graphite, aluminum and copper layers contained in a helium-filled enclosure. This paper describes the mechanical implementation of the beam absorbers, with a focus on thermal design and analysis. The potential for radiation-induced degradation of the graphite is discussed.

  11. Mayoral Governance and Student Achievement: How Mayor-Led Districts Are Improving School and Student Performance

    ERIC Educational Resources Information Center

    Wong, Kenneth K.; Shen, Francis X.

    2013-01-01

    Mayoral control and accountability is one of very few major education reforms that aim at governance coherence in this nation's highly fragmented urban school systems. A primary feature of mayoral governance is that it holds the office of the mayor accountable for school performance. As an institutional redesign, mayoral governance integrates…

  12. Mayoral School Leadership and Integrated Governance

    ERIC Educational Resources Information Center

    Center for the Study of Education Policy, 2009

    2009-01-01

    The past two decades have seen an emerging trend in urban school governance: mayors taking the reins of school district leadership. The impetus for putting the mayor in charge of a city's schools usually stems from at least one of the following being documented or generally perceived about an urban school district: (1) Lack of accountability; (2)…

  13. Mayoral Control in the Windy City

    ERIC Educational Resources Information Center

    Russo, Alexander

    2014-01-01

    When former U.S. congressman and Obama administration chief of staff Rahm Emanuel marched triumphantly into the Chicago mayor's office in 2011, he promised to revamp Chicago Public Schools (CPS) in ways that had barely been contemplated in 16 years of mayoral control over the city's sprawling public-school system. This article discusses…

  14. Performance and race in evaluating minority mayors.

    PubMed

    Howell, S E

    2001-01-01

    This research compares a performance model to a racial model in explaining approval of a black mayor. The performance model emphasizes citizen evaluations of conditions in the city and the mayor's perceived effectiveness in dealing with urban problems. The racial model stipulates that approval of a black mayor is based primarily on racial identification or racism. A model of mayoral approval is tested with two surveys over different years of citizens in a city that has had 20 years' experience with black mayors. Findings indicate that performance matters when evaluating black mayors, indicating that the national performance models of presidential approval are generalizable to local settings with black executives. Implications for black officeholders are discussed. However, the racial model is alive and well, as indicated by its impact on approval and the finding that, in this context, performance matters more to white voters than to black voters. A final, highly tentative conclusion is offered that context conditions the relative power of these models. The performance model may explain more variation in approval of the black mayor than the racial model in a context of rapidly changing city conditions that focuses citizen attention on performance, but during a period of relative stability the two models are evenly matched.

  15. The Mayor's Role in School Desegregation Implementation

    ERIC Educational Resources Information Center

    Rossell, Christine

    1977-01-01

    Successful, or at least nonviolent, strategy for school desegregation depends upon the city's social and political structure. Mayors should plan school desegregation policy as part of a total approach to urban renewal. (Author/GC)

  16. Aztec Mexico: Discovery of Templo Mayor.

    ERIC Educational Resources Information Center

    Breslav, Marc

    1982-01-01

    Describes the Aztec archaeological artifacts shown in the American Museum of Natural History exhibit: "Aztec Mexico: Discovery of Templo Mayor." More than 100 objects, ranging from human skulls to jewelry, found in the excavation of the Great Temple of Mexico located under the center of Mexico City, were displayed. (AM)

  17. Templo Mayor, Tenochtitlan - Calendar and Astronomy

    NASA Astrophysics Data System (ADS)

    Galindo Trejo, Jesús

    The Templo Mayor of Tenochtitlan was the principal symbol of political power and religious control of the Mexicas. Its orientation was chosen according to ancestral calendrical traditions that considered the Mesoamerican calendar as a sacred concern. The solar alignments incorporated into this emblematic building symbolized moments that divided the solar year according to basic properties of the Mesoamerican calendar.

  18. Welcome by the Mayor of Valtetsi

    NASA Astrophysics Data System (ADS)

    Papanikolau, N.

    Welcome by the Mayor of Valtetsi Mr. Chairman Ladies and Gentlemen The municipality of Valtetsi welcomes you and wishes success in your work. Arcadia is both a historical and modern region. Moreover, as a name it remained in the western culture recalling a harmonious and peaceful dream, a lost and desirable situation where the human being lived in balance with nature, a region where the person did not feel yet uprooted. For thousands of years the poetic voices retained vivid this eternal bucolic call of simplicity and accessible happiness. Gazing the starlit sky we will always see Kallisto, the daughter of Lykaona, king of Arcadia and her son Arcadian as they were both transformed in to the constellations Major and Minor Ursus because of the erotic libido of Jupiter and the jealousy of Hera. And we will always remember Centaurus Cheirona, the great schoolteacher of ancient heroes, who was the first to name the constellations according to mythology. Finally we would like to thank the patriot Mr. T. Tzioumi who returns to his beautiful village in Arcadia just like Antaios did. In the geographic place that inspired the arcadian ideal, such activities recall in the limelight Arcadia as was dreamed by Europe. Mr. Chairman, ladies and gentlemen, success in your scientific work. The Municipality of Valtetsi and I myself will be always next to you so that your stay at Arcadia will always remain vivid in your memory. Thank you. Nikos Papanikolaou Mayor of Valtetsi

  19. Impact of Radio Ads on New Mexico Mayoral Races.

    ERIC Educational Resources Information Center

    McCleneghan, J. Sean

    1987-01-01

    Compares local radio advertising with small daily and weekly newspapers in influencing the outcome of 11 New Mexico mayoral races in 1986. Reports that the 11 winning mayoral candidates paid attention to radio political advertising in their media mix. (MM)

  20. The Political Dynamics of Mayoral Engagement in Public Education

    ERIC Educational Resources Information Center

    Wong, Kenneth K.

    2006-01-01

    Like many urban reform strategies, mayoral leadership in education has both proponents and skeptics. On the one hand, proponents argue that mayor-led initiatives have the potential to transform low-performing schools and to hold schools and students accountable to systemwide standards. On the other hand, skeptics see mayoral involvement as…

  1. Detection of virulence factors of Escherichia coli focused on prevalence of EAST1 toxin in stool of diarrheic and non-diarrheic piglets and presence of adhesion involving virulence factors in astA positive strains.

    PubMed

    Zajacova, Zuzana Sramkova; Konstantinova, Lucie; Alexa, Pavel

    2012-01-27

    Between 2005 and 2009, a total of 800 Escherichia coli strains isolated from piglets with diarrhea were tested for the presence of enteroaggregative heat-stable enterotoxin EAST1, heat-labile (LT) and heat-stable enterotoxins (STa) and shigatoxin (Stx2e) by PCR with the purpose of investigating the present distribution of virulence factors on swine farms in the Czech Republic. The isolates were analyzed for their O-serogroup, fimbrial (K88, K99, 987P, F41, F18) and nonfimbrial adhesins (adhesin involved in diffuse adherence AIDA and porcine attaching and effacing-associated factor PAA). The detection rates of ETEC and STEC isolates were 36.5% and 7.75%, respectively, which implies that ETEC play the major role in E. coli infections in Czech herds. Generally, the most common serotype was O149:K88 which possessed genetic determinants for LT and EAST1. None of the tested E. coli isolates was positive for genes K99, 987P and F41. It was shown that out of 800 E. coli strains isolated from pigs, 277 were EAST1 positive and 74% from the latter were identified as ETEC. Of the fimbrial adhesins, K88 and F18 were commonly detected. Over 80% of K88/EAST1 positive strains possessed the gene for paa. We detected no EAE isolate positive for fimbrial adhesins or PAA and AIDA. The AIDA was more often associated with F18 than with K88. The gene astA was also identified among E. coli isolates of non-diarrheic piglets. We tested rectal swab samples collected from apparently healthy piglets on three farms. On all farms, E. coli astA positive strains (26.66%, 90.00% and 46.66% astA positive animals) were isolated. Our results showed a significantly higher prevalence of astA positive E. coli isolates among apparently healthy piglets in comparison with diarrheic piglets. The question remains as to what is the role of the astA gene in the pathogenesis of porcine colibacillosis and as a virulence factor. PMID:21864997

  2. Indianapolis Mayor Bart Peterson: The Peyton Manning of Charter Schools

    ERIC Educational Resources Information Center

    Skinner, David

    2007-01-01

    Indianapolis Mayor Bart Peterson has laid down a bold challenge to the city's troubled public school system: improve or see your students migrate to the city's growing roster of impressive charter schools. This is no idle threat. In the 2006-2007 academic year, the mayor oversaw 16 charter schools serving 3,870 students. Peterson is currently the…

  3. Priorities for "The New American City." Mayors 2001.

    ERIC Educational Resources Information Center

    Coles, H. Brent

    This report focuses on the scope and potential of the New American City, a term employed by entrepreneurial mayors who have forged partnerships with businesses, nonprofits, and other governmental entities to improve the quality of life in their cities. U.S. mayors believe that it is possible to strengthen and maintain the growth of the New…

  4. Some problems of Maryland towns as seen by their mayors

    NASA Technical Reports Server (NTRS)

    Peake, H. J.

    1978-01-01

    Conversations were held with the mayors of six Maryland towns to discuss possible models and needs for technology transfer. An unexpected outcome of the discussions was a considerable insight into local problems as perceived by the mayors. Problems, whether administrative, socio-economic, or technological, are different, from town to town, in degree, not in kind. Recognition of this feature of local priorities is vital to any considerations of external assistance.

  5. Salud mental en desastres naturales: estrategias interventivas con adultos mayores en sectores rurales de Chile.

    PubMed

    Osorio-Parraguez, Paulina; Espinoza, Adriana

    2016-06-01

    En el presente artículo se da a conocer una estrategia de intervención llevada a cabo con adultos mayores en la comuna de Paredones, sexta región de Chile, con posterioridad al terremoto y tsunami del 27 de febrero 2010 en Chile, en el contexto de una investigación sobre fortalezas y vulnerabilidades desplegadas por este grupo etario, con posterioridad a un desastre natural. Se presenta una descripción del desarrollo metodológico de la intervención y de los sustentos teóricos y conceptuales en los que se basa. Como resultado de este proceso, se propone una estrategia que trabaje a través de la identificación de las propias experiencias y fortalezas de los sujetos. De tal forma se minimizan los efectos negativos de los determinantes sociales de la salud (como la edad y el lugar de residencia) en contexto de crisis; permitiendo a los adultos mayores fortalecer sus recursos individuales y colectivos, en pro de su bienestar psicosocial.

  6. Salud mental en desastres naturales: estrategias interventivas con adultos mayores en sectores rurales de Chile.

    PubMed

    Osorio-Parraguez, Paulina; Espinoza, Adriana

    2016-06-01

    En el presente artículo se da a conocer una estrategia de intervención llevada a cabo con adultos mayores en la comuna de Paredones, sexta región de Chile, con posterioridad al terremoto y tsunami del 27 de febrero 2010 en Chile, en el contexto de una investigación sobre fortalezas y vulnerabilidades desplegadas por este grupo etario, con posterioridad a un desastre natural. Se presenta una descripción del desarrollo metodológico de la intervención y de los sustentos teóricos y conceptuales en los que se basa. Como resultado de este proceso, se propone una estrategia que trabaje a través de la identificación de las propias experiencias y fortalezas de los sujetos. De tal forma se minimizan los efectos negativos de los determinantes sociales de la salud (como la edad y el lugar de residencia) en contexto de crisis; permitiendo a los adultos mayores fortalecer sus recursos individuales y colectivos, en pro de su bienestar psicosocial. PMID:25724751

  7. Mayors and Public Education: The Case for Greater Involvement

    ERIC Educational Resources Information Center

    Usdan, Michael D.

    2006-01-01

    Over the last generation, a new politics of education has evolved throughout the United States. Since the 1983 watershed report "A Nation at Risk" (National Commission on Excellence in Education, 1983), the country's most influential business and political leaders--and, more recently, mayors--have spearheaded efforts to improve student achievement…

  8. Will Mayor De Blasio Turn Back the School Reform Clock?

    ERIC Educational Resources Information Center

    Meyer, Peter

    2014-01-01

    While heads were spinning, policy watchers seemed genuinely perplexed by New York City's Mayor de Blasio's education opinions. De Blasio opposed many of Bloomberg's reform efforts despite the achievement gains realized by the nation's largest school district during the last 12 years. Yet on close reading, de Blasio's…

  9. Grading the Mayor: Agenda-Setting in Defiance, Ohio.

    ERIC Educational Resources Information Center

    Christy, Karen J.

    In an attempt to explore the press's power to influence its readers and viewers, a study replicated other agenda-setting research using content analysis of the media and a telephone survey of residents of Defiance, Ohio. Subjects, 364 residents (representing a 45% response rate), were asked to grade the mayor on the best and worst things he had…

  10. DIABETES MELLITUS COMO FACTOR DE RIESGO DE DEMENCIA EN LA POBLACIÓN ADULTA MAYOR MEXICANA

    PubMed Central

    Silvia, Mejía-Arango; Clemente, y Zúñiga-Gil

    2012-01-01

    Introduccion La diabetes mellitus y las demencias constituyen dos problemas crecientes de salud entre la población adulta mayor del mundo y en particular de los paises en desarrollo. Hacen falta estudios longitudinales sobre el papel de la diabetes como factor de riesgo para demencia. Objetivo Determinar el riesgo de demencia en sujetos Mexicanos con diabetes mellitus tipo 2. Materiales y Metodos Los sujetos diabéticos libres de demencia pertenecientes al Estudio Nacional de Salud y Envejecimiento en México fueron evaluados a los dos años de la línea de base. Se estudió el papel de los factores sociodemográficos, de otras comorbilidades y del tipo de tratamiento en la conversión a demencia. Resultados Durante la línea de base 749 sujetos (13.8%) tuvieron diabetes. El riesgo de desarrollar demencia en estos individuos fue el doble (RR, 2.08 IC 95%, 1.59–2.73). Se encontró un riesgo mayor en individuos de 80 años y más (RR 2.44 IC 95%, 1.46–4.08), en los hombres (RR, 2.25 IC 95%, 1.46–3.49) y en sujetos con nivel educativo menor de 7 años. El estar bajo tratamiento con insulina incrementó el riesgo de demencia (RR, 2.83, IC 95%, 1.58–5.06). Las otras comorbilidades que aumentaron el riesgo de demencia en los pacientes diabéticos fueron la hipertensión (RR, 2.75, IC 95%, 1.86–4.06) y la depresión (RR, 3.78, 95% IC 2.37–6.04). Conclusión Los sujetos con diabetes mellitus tienen un riesgo mayor de desarrollar demencia, La baja escolaridad y otras comorbilidades altamente prevalentes en la población Mexicana contribuyen a la asociación diabetes-demencia. PMID:21948010

  11. Mayor's Firm Hand over N.Y.C. Schools Sparks New Debate

    ERIC Educational Resources Information Center

    Archer, Jeff

    2004-01-01

    This article reports a new debate on mayoral control over New York City schools. Mayoral control of the N.Y.C. schools was at the center of renewed debate, after Mayor Michael R. Bloomberg replaced two members of the city's education policymaking board to ensure enough votes for a controversial plan he backed to end social promotion. The shakeup…

  12. Chartering New Waters: The Indianapolis Mayoral Transition and the Charter School Community

    ERIC Educational Resources Information Center

    Prusinski, Ellen L.; Ruddy, Anne-Maree; Plucker, Jonathan A.; Cierniak, Katherine A.

    2015-01-01

    As the first mayor in the United States to possess independent charter school authorizing authority, Mayor Bart Peterson oversaw the establishment and expansion of Indianapolis's ambitious charter school initiative. In 2007, Democratic Mayor Peterson's oversight of the initiative came to an end when he was unexpectedly defeated by Republican…

  13. Evolution of a Quaternary peralkaline volcano: Mayor Island, New Zealand

    USGS Publications Warehouse

    Houghton, B.F.; Weaver, S.D.; Wilson, C.J.N.; Lanphere, M.A.

    1992-01-01

    Mayor Island is a Holocene pantelleritic volcano showing a wide range of dispersive power and eruptive intensity despite a very limited range in magma composition of only 2% SiO2. The primary controls on this range appear to have been the magmatic gas content on eruption and a varying involvement of basaltic magma, rather than major-element chemistry of the rhyolites. The ca. 130 ka subaerial history of the volcano contains portions of three geochemical cycles with abrupt changes in trace-element chemistry following episodes of caldera collapse. The uniform major-element chemistry of the magma may relate to a fine balance between rates of eruption and supply and the higher density of the more evolved (Ferich) magmas which could be tapped only after caldera-forming events had removed significant volumes of less evolved but lighter magma. ?? 1992.

  14. A Case Study in Policy Change: Mayoral Control in New York City's Schools

    ERIC Educational Resources Information Center

    McGlynn, Adam

    2010-01-01

    During the 33 years New York City schools were controlled primarily by community school boards, the city's mayors posited that greater mayoral influence was the cure for the ills afflicting the city's schools. This paper applies theories of policy change to the 30-year battle for control of New York's schools while highlighting the role of the…

  15. Building Suburban Dreams: School District Secession and Mayoral Control in Suburban Utah

    ERIC Educational Resources Information Center

    Buendia, Edward; Humbert-Fisk, Paul

    2015-01-01

    Background/Context: Mayoral control of large city school districts has become the newest form of school district reorganization. Researchers have documented how real and perceived crises have propelled mayors in Chicago, Baltimore, and Washington DC, amongst others, to redefine the role of board governance by situating the operations of districts…

  16. Identifying the Causes of Mayoral Control in Urban Public School Systems

    ERIC Educational Resources Information Center

    McGlynn, Adam J.

    2010-01-01

    Absent from the literature on mayoral control of urban public schools are quantitative studies that create a coherent theory of why mayoral control occurs. This article attempts to fill this gap by analyzing 47 urban school districts from 1991 to 2002, using a Cox Proportional Hazards model to assess the effects of political, economic, and…

  17. Preparación de los adultos mayores en los Estados Unidos para hacer frente a los desastres naturales: encuesta a escala nacional*

    PubMed Central

    Al-rousan, Tala M.; Rubenstein, Linda M.; Wallace, Robert B.

    2015-01-01

    Objetivos. Nos propusimos determinar el grado de preparación frente a los desastres naturales de los adultos mayores en los Estados Unidos y evaluar los factores que pueden afectar negativamente la salud y la seguridad durante este tipo de incidentes. Métodos. Obtuvimos una muestra de adultos de 50 años en adelante (n = 1 304) de la encuesta del 2010 del Estudio de la Salud y la Jubilación (HRS por su sigla en inglés). La encuesta recogió datos sobre las características demográficas generales, el estado de discapacidad o las limitaciones funcionales, y también sobre factores y comportamientos relacionados con la preparación frente a los desastres. Calculamos una puntuación global de preparación mediante indicadores individuales a fin de evaluar el grado de preparación general. Resultados. La media de la edad de los participantes (n = 1 304) fue de 70 años (desviación estándar [DE] = 9,3). Solo 34,3% informaron que habían participado en un programa formativo o que habían leído materiales sobre la preparación para los desastres. Casi 15% indicaron que usaban dispositivos médicos eléctricos que podían correr riesgo de no funcionar si se interrumpiera el suministro eléctrico. La puntuación de preparación indicó que la edad más avanzada, la discapacidad física y el menor nivel de escolaridad y de ingresos se asociaban independiente y significativamente a un grado de preparación general inferior. Conclusiones. A pesar de la mayor vulnerabilidad ante los desastres y del número cada vez mayor de adultos mayores en los Estados Unidos, muchos de los problemas sustanciales que encontramos son remediables y requieren atención en los sectores de la sociedad dedicados a la atención clínica, a la salud pública y al manejo de situaciones de emergencia.

  18. Changing Course on School Reform: Strategic Organizing around the New York City Mayoral Election

    ERIC Educational Resources Information Center

    Easton, Billy

    2014-01-01

    New York City's new mayor, Bill de Blasio, represents a dramatic shift from his predecessor Michael Bloomberg in the area of education. Bloomberg was a national trendsetter on market reforms focused on privatization, testing, and competition. De Blasio was elected on an agenda of classroom investments, student supports, parent and community…

  19. L.A. Mayor Seeks Role in District: Villaraigosa Wants State Law Stripping Board of Powers

    ERIC Educational Resources Information Center

    Maxwell, Lesli A.

    2006-01-01

    After months of deliberations and promises of dramatic change for Los Angeles' embattled schools, Mayor Antonio Villaraigosa the week of April 17, 2006 called for California lawmakers to put his office in charge of running the day-to-day operations of the nation's second largest school district. In his first State of the City address, Mr.…

  20. Looking for Leadership: Assessing the Case for Mayoral Control of Urban School Systems

    ERIC Educational Resources Information Center

    Hess, Frederick M.

    2008-01-01

    Replacing boards of education conceived during the Progressive Era with mayoral control has been a popular reform strategy in urban districts such as Boston, Chicago, and New York City. A thorough review of the extant research, however, shows little evidence regarding its impact on governance, management, school organization, or teaching and…

  1. Community Support for Mayoral Control of Urban School Districts: A Critical Reexamination

    ERIC Educational Resources Information Center

    Shen, Francis X.

    2012-01-01

    This article challenges the view that citywide referenda alone are an effective means of ensuring accountability for mayoral control. Through new empirical analysis of the referenda results in Boston and Cleveland, the article shows that rather than establish genuine democratic legitimacy, the referenda in fact mask strong class-based, and in…

  2. Getting Hold of District Finances: A Make-or-Break Issue for Mayoral Involvement in Education

    ERIC Educational Resources Information Center

    Hill, Paul T.

    2006-01-01

    In this essay, the author calls attention to a little-studied but critical aspect of school system reform: the nontransparent and sometimes illogical ways school districts allocate funds and personnel, especially teachers. Drawing on a series of studies produced by his Center for Reinventing Public Education, the author asserts that mayors who…

  3. Redesigning Urban Districts in the USA: Mayoral Accountability and the Diverse Provider Model

    ERIC Educational Resources Information Center

    Wong, Kenneth K.

    2011-01-01

    In response to public pressure, urban districts in the USA have initiated reforms that aim at redrawing the boundaries between the school system and other major local institutions. More specifically, this article focuses on two emerging reform strategies. We will examine an emerging model of governance that enables big-city mayors to establish…

  4. Attitudes and Perceptions of Vocational Education in New York City: Implications for the Mayor's School Reform Initiative

    ERIC Educational Resources Information Center

    Green, Rupert

    2012-01-01

    Under-performing New York City (NYC) schools precipitated Mayor Michael Bloomberg's decision to advance a vocational education initiative. The initiative was to address the problem of the many city high school graduates lacking both the skills for gainful employment and the academic preparedness to pursue higher education. The mayor's initiative…

  5. Resultado negativo de prueba del VPH es mejor predictor de riesgo bajo de cáncer de cuello uterino

    Cancer.gov

    De acuerdo con un estudio en el que participaron más de un millón de mujeres, los investigadores del NCI han determinado que el resultado negativo de una prueba para la detección del VPH proporciona mayor certeza o seguridad frente a riesgos futuros de cá

  6. Sustaining and Strengthening DC Schools: Challenges and Choices for the New Mayor

    ERIC Educational Resources Information Center

    Gallagher, Megan; Bogle, Mary

    2014-01-01

    Mayor-elect Bowser assumed control at a delicate juncture in the turbulent history of DC schools. In the 2008-09 school year, public school enrollment--in both traditional and charter schools--increased for the first time since the 1960s. In 2013-14, the District had the largest student body in over 25 years, and over the past 15 years, public…

  7. The role of a keystone fault in triggering the complex El Mayor-Cucapah earthquake rupture

    NASA Astrophysics Data System (ADS)

    Fletcher, John M.; Oskin, Michael E.; Teran, Orlando J.

    2016-04-01

    The 2010 Mw 7.2 El Mayor-Cucapah earthquake in Baja California, Mexico activated slip on multiple faults of diverse orientations, which is commonly the case for large earthquakes. The critical stress level for fault failure depends on fault orientation and is lowest for optimally oriented faults positioned approximately 30° to the greatest principal compressive stress. Yet, misoriented faults whose positioning is not conducive to rupture are also common. Here we use stress inversions of surface displacement and seismic data to show that the El Mayor-Cucapah earthquake initiated on a fault that, owing to its orientation, was among those that required the greatest stress for failure. Although other optimally oriented faults must have reached critical stress earlier in the interseismic period, Coulomb stress modelling shows that slip on these faults was initially muted because they were pinned, held in place by misoriented faults that helped regulate their slip. In this way, faults of diverse orientations could be maintained at critical stress without destabilizing the network. We propose that regional stress build-up continues until a misoriented keystone fault reaches its threshold and its failure then spreads spontaneously across the network in a large earthquake. Our keystone fault hypothesis explains seismogenic failure of severely misoriented faults such as the San Andreas fault and the entire class of low-angle normal faults.

  8. Deformation associated with the 2010 Sierra El Mayor earthquake from GPS and InSAR

    NASA Astrophysics Data System (ADS)

    Funning, G. J.; Floyd, M. A.; Ben-Zion, D.

    2010-12-01

    The 4 April 2010, M7.2 Sierra El Mayor earthquake ruptured over 50 km of a system of faults located on the western side of the Sierra El Mayor mountains, where they meet the dry lake Laguna Salada. The terrain in the region is mostly poorly vegetated desert, and thus a promising target for InSAR. We use L-band radar data from the PALSAR instrument on the Japanese ALOS satellite, to generate SAR interferograms of the epicentral area spanning the earthquake and the early postseismic period. Coseismic offsets in satellite line-of-sight are in some places greater than 1.5 m, indicating peak right-lateral fault slip of approximately double that amount. Azimuth offsets, calculated at high resolution for the same data, are used to map the location of the earthquake surface rupture. We supplement these data with GPS data - a relatively dense network of continuous data from north of the US-Mexico border, and a sparse network of semi-continuous and campaign GPS data collected by UCR, Scripps and CICESE south of the border. Near-field sites show transient deformation on a timescale of weeks to months following the earthquake. Preliminary inverse models indicate a oblique-normal mode of slip may provide the best fit to the coseismic data, consistent with preliminary focal mechanisms and the local geomorphology; the geodetic moment-magnitude of 7.2 for these models is also in line with those estimated seismically.

  9. "Good Politics Is Good Government": The Troubling History of Mayoral Control of the Public Schools in Twentieth-Century Chicago

    ERIC Educational Resources Information Center

    Carl, Jim

    2009-01-01

    This article looks at urban education through the vantage point of Chicago's mayors. It begins with Carter H. Harrison II (who served from 1897 to 1905 and again from 1911 to 1915) and ends with Richard M. Daley (1989 to the present), with most of the focus on four long-serving mayors: William Hale Thompson (1915-23 and 1927-31), Edward Kelly…

  10. Estudio del NCI revela que la obesidad extrema puede acortar la esperanza de vida hasta en 14 años

    Cancer.gov

    Los adultos con obesidad extrema tienen mayor riesgo de morir a edad más joven por cáncer y muchas otras causas entre ellas, enfermedades cardíacas, accidentes cerebrovasculares, diabetes y enfermedades del hígado y los riñones, según estudio del NCI.

  11. Near-field deformation from the El Mayor-Cucapah earthquake revealed by differential LIDAR.

    PubMed

    Oskin, Michael E; Arrowsmith, J Ramon; Hinojosa Corona, Alejandro; Elliott, Austin J; Fletcher, John M; Fielding, Eric J; Gold, Peter O; Gonzalez Garcia, J Javier; Hudnut, Ken W; Liu-Zeng, Jing; Teran, Orlando J

    2012-02-10

    Large [moment magnitude (M(w)) ≥ 7] continental earthquakes often generate complex, multifault ruptures linked by enigmatic zones of distributed deformation. Here, we report the collection and results of a high-resolution (≥nine returns per square meter) airborne light detection and ranging (LIDAR) topographic survey of the 2010 M(w) 7.2 El Mayor-Cucapah earthquake that produced a 120-kilometer-long multifault rupture through northernmost Baja California, Mexico. This differential LIDAR survey completely captures an earthquake surface rupture in a sparsely vegetated region with pre-earthquake lower-resolution (5-meter-pixel) LIDAR data. The postevent survey reveals numerous surface ruptures, including previously undocumented blind faults within thick sediments of the Colorado River delta. Differential elevation changes show distributed, kilometer-scale bending strains as large as ~10(3) microstrains in response to slip along discontinuous faults cutting crystalline bedrock of the Sierra Cucapah. PMID:22323817

  12. Did stresses from the Cerro Prieto Geothermal Field influence the El Mayor-Cucapah rupture sequence?

    NASA Astrophysics Data System (ADS)

    Trugman, Daniel T.; Borsa, Adrian A.; Sandwell, David T.

    2014-12-01

    The Mw 7.2 El Mayor-Cucapah (EMC) earthquake ruptured a complex fault system in northern Baja California that was previously considered inactive. The Cerro Prieto Geothermal Field (CPGF), site of the world's second largest geothermal power plant, is located approximately 15 km to the northeast of the EMC hypocenter. We investigate whether anthropogenic fluid extraction at the CPGF caused a significant perturbation to the stress field in the EMC rupture zone. We use Advanced Land Observing Satellite interferometric synthetic aperture radar data to develop a laterally heterogeneous model of fluid extraction at the CPGF and estimate that this extraction generates positive Coulomb stressing rates of order 15 kPa/yr near the EMC hypocenter, a value which exceeds the local tectonic stressing rate. Although we cannot definitively conclude that production at the CPGF triggered the EMC earthquake, its influence on the local stress field is substantial and should not be neglected in local seismic hazard assessments.

  13. Getting food policy on the Mayoral table: a comparison of two election cycles in New York and London.

    PubMed

    Freudenberg, N; Atkinson, S

    2015-04-01

    Cities and Mayors are increasingly being recognized as important in shaping social policy and improving social well-being. And municipal food policies are increasingly important as a tool to reduce food insecurity and prevent diet-related chronic diseases. Thus city governments have a unique ability to improve local food environments. To realize this potential for improving urban food environments, nutrition advocates will need to find innovative approaches for influencing municipal food policy. This paper examines Mayoral elections as a vehicle to advance food policy. To explore this strategy, Mayoral elections in two cities, New York City (NYC) and London, during two recent cycles were compared. To gather evidence multiple sources were used including campaign documents, media and opinion polls as well as the authors' own observations as food policy observers and participants in the two cities. Mayoral governance differs between NYC and London, with the Mayor in NYC having greater powers of management and administration, whilst the London Mayor has a more strategic role and may need to also use 'influence'. Food policy and related issues did not feature strongly in the first election cycles in either city. However by the 2012 and 2013 elections food issues were definitely 'on the table' and featured in main candidates' campaign literature. These latter elections also saw the importance of food advocates coming together to form common alliances and place food issues higher on the municipal agenda. In this way, food policy has become part of the election dialogue in both cities and candidates are expected to consider food policy issues. This analysis leads to make observations which could guide advocates as to how to use Mayoral elections to raise policy objectives for the benefit of public health. PMID:25834929

  14. A dated pollen record of vegetation change on Mayor Island (Tuhua) throughout the last 3000 years

    NASA Astrophysics Data System (ADS)

    Empson, Leighanne; Flenley, John; Sheppard, Peter

    2002-07-01

    Pollen data are presented from Mayor Island, Bay of Plenty. The island was important in prehistory as a source of obsidian (Seelenfreund, A., Bollong, C., 1989. The sourcing of New Zealand obsidian artefacts using energy dispersive XRF Spectroscopy. In: D. Sutton (Editor), Saying So Doesn't Make It So: Papers in honour of B. Foss Leach. New Zealand Archaeological Association Monograph, Wellington, pp. 168-189.) and holds a strategic location relative to the settlement of the North Island of New Zealand since it lies on possible arrival routes from Polynesia, and also relative to travel up and down the east coast of the North Island. The pollen data show that the island was generally forested between c. 3000 and c. 450 BP, when forest declined and the bracken fern Pteridium esculentum (and charcoal) increased. Before significant forest decline at 450 BP, which is consistent with Maori occupation at the time of the fortified settlements known as pa, there is evidence of other episodes of vegetation disturbance dating back to c. 2200 BP which may represent earlier visits by people.

  15. Adding Up the Numbers: The Education Budget under Mayoral Control. Update and Summary of 2005-06 EPP Bulletins

    ERIC Educational Resources Information Center

    Connell, Noreen

    2007-01-01

    For more than a century, a succession of New York City (NYC) mayors have claimed that they were reducing administrative overhead in the school system and driving more resources to instruction. These claims have been dutifully reported by the press with rarely any effort to verify them. For the last 50 years, the salaries of teachers were increased…

  16. The Mayor's Plan for Achieving Success in the DCPS: Is the Implementation Likely to Match the Vision?

    ERIC Educational Resources Information Center

    Council of the Great City Schools, 2007

    2007-01-01

    The Mayor Adrian Fenty's achievement plan for the District of Columbia Public Schools (DCPS) is divided into four major parts. The first section outlines the philosophical foundation undergirding the plan. The second section outlines the plan's goals and strategies. In preparing this commentary, the Council of the Great City Schools assessed how…

  17. Los Angeles Takes over Its School District: An Overview of Mayor Antonio Villaraigosa's Bid to Restructure LAUSD. Policy Note

    ERIC Educational Resources Information Center

    Ramirez, Hernan

    2007-01-01

    Across the nation, takeovers of schools or entire systems by mayors, state legislatures, or control boards have come as a result of increasing pressure to improve low performing schools, particularly those in central cities serving disadvantaged or minority students. Citing a need for improvement in the city's schools, Antonio Villaraigosa…

  18. Postseismic Deformation Following the 2010 El Mayor-Cucapah Earthquake: Observations, Kinematic Inversions, and Dynamic Models

    NASA Astrophysics Data System (ADS)

    Rollins, Christopher; Barbot, Sylvain; Avouac, Jean-Philippe

    2015-05-01

    Due to its location on a transtensional section of the Pacific-North American plate boundary, the Salton Trough is a region featuring large strike-slip earthquakes within a regime of shallow asthenosphere, high heat flow, and complex faulting, and so postseismic deformation there may feature enhanced viscoelastic relaxation and afterslip that is particularly detectable at the surface. The 2010 El Mayor-Cucapah earthquake was the largest shock in the Salton Trough since 1892 and occurred close to the US-Mexico border, and so the postseismic deformation recorded by the continuous GPS network of southern California provides an opportunity to study the rheology of this region. Three-year postseismic transients extracted from GPS displacement time-series show four key features: (1) 1-2 cm of cumulative uplift in the Imperial Valley and 1 cm of subsidence in the Peninsular Ranges, (2) relatively large cumulative horizontal displacements 150 km from the rupture in the Peninsular Ranges, (3) rapidly decaying horizontal displacement rates in the first few months after the earthquake in the Imperial Valley, and (4) sustained horizontal velocities, following the rapid early motions, that were still visibly ongoing 3 years after the earthquake. Kinematic inversions show that the cumulative 3-year postseismic displacement field can be well fit by afterslip on and below the coseismic rupture, though these solutions require afterslip with a total moment equivalent to at least a earthquake and higher slip magnitudes than those predicted by coseismic stress changes. Forward modeling shows that stress-driven afterslip and viscoelastic relaxation in various configurations within the lithosphere can reproduce the early and later horizontal velocities in the Imperial Valley, while Newtonian viscoelastic relaxation in the asthenosphere can reproduce the uplift in the Imperial Valley and the subsidence and large westward displacements in the Peninsular Ranges. We present two forward

  19. The Mayor of EarthCube: Cities as an Analogue for Governing Cyberinfrastructure

    NASA Astrophysics Data System (ADS)

    Pearthree, G. M.; Allison, M. L.; Patten, K.

    2012-12-01

    Historical development of national and global infrastructure follows common paths with common imperatives. The nascent development may be led a by champion, innovator, or incubating organization. Once the infrastructure reaches a tipping point and adoption spreads rapidly, the organization and governance evolves in concert. Ultimately, no wide-spread infrastructure (from canals to highways to the electric grid to radio/television, or the Internet) operates with a single overarching governing body. The NSF EarthCube initiative is a prototype implementation of cyberinfrastructure, using the broad geoscience community as the testbed. Governance for EarthCube is emulating the pattern of other infrastructure, which we argue is a system of systems that can be described by organized complexity, emergent systems, and non-linear thermodynamics. As we consider governance cyberinfrastructure in the geosciences, we might look to cities as analogs: cities provide services such as fire, police, water, and trash collection. Cities issue permits and often oversee zoning, but much of what defines cities is outside the direct control of city government. Businesses choose whether to locate there, where to operate, and what to build. Residents make similar decisions. State and federal agencies make decisions or impose criteria that greatly affect cities, without necessarily getting agreement from them. City government must thus operate at multiple levels - providing oversight and management of city services, interaction with residents, businesses, and visitors, and dealing with actions and decisions made by independent entities over which they have little or no control. Cities have a range of organizational and management models, ranging from city managers, councils, and weak to strong mayors, some elected directly, some chosen from councils. The range and complexity of governance issues in building, operating, and sustaining cyberinfrastructure in the geosciences and beyond, rival

  20. Tectonic Geomorphology of an Active Low-Angle Normal Fault, Sierra El Mayor, Northern Baja California

    NASA Astrophysics Data System (ADS)

    Fletcher, J. M.; Spelz, R.

    2007-05-01

    Low angle normal faults (LANF) are ubiquitously distributed throughout the northern Gulf of California. They commonly bound uplifted mountain ranges and are found in numerous seismic sections in the Altar Desert and Wagner Basin (A. Martin, unpublished data). The Canada David detachment (CDD) is a spectacular example of an active LANF that controls the western mountain front of Sierra El Mayor over a strike length of 60 Km. Like most LANFs, the CDD contains two prominent antiform-synform megamullion pairs that strongly control the tectonic geomorphology of the uplifted footwall block and alluvial terraces along the range flank. Quantitative morphometric analysis along the mountain front shows that drainage basins in antiformal domains have systematically higher outlet elevations, higher gradients, greater relief, and much greater hypsometric integrals. Additionally river valleys are narrower and dominated by bedrock channels that extend nearly to the outlet, which is consistent with the fact that mountain front sinuosity is almost an order of magnitude less in the antiformal domains. A sequence of as many as 8 different regional strath terraces are preserved along the range flank and reconnaissance dating of the deposits by cosmogenic isotopes suggests that they formed during the major interglacial-to-glacial climatic transitions. Strath terraces are generally much older, and relative heights between terraces is significantly lower in synformal domains. All of these geomorphologic characteristics suggest that the synformal domains have experienced much lower rates of uplift and erosion of the footwall and likewise lower rates of sedimentation in the adjacent hanging wall basin. The lack of slip gradients on the master fault between synformal and antiformal domains suggests that the megamullions formed instead by regional buckling perpendicular to the extension direction. A Quaternary scarp array extends along the entire length of the mountain front and also shows

  1. GPS Time Series Analysis of Southern California Associated with the 2010 M7.2 El Mayor/Cucapah Earthquake

    NASA Technical Reports Server (NTRS)

    Granat, Robert; Donnellan, Andrea

    2011-01-01

    The Magnitude 7.2 El-Mayor/Cucapah earthquake the occurred in Mexico on April 4, 2012 was well instrumented with continuous GPS stations in California. Large Offsets were observed at the GPS stations as a result of deformation from the earthquake providing information about the co-seismic fault slip as well as fault slip from large aftershocks. Information can also be obtained from the position time series at each station.

  2. Estudio del sistema simbiótico AR Pavonis

    NASA Astrophysics Data System (ADS)

    Quiroga, C.; Brandi, E.; Ferrer, O.; García, L.; Barbá, R.

    Se presenta un estudio espectroscópico y polarimétrico de la binaria eclipsante AR Pavonis a partir de observaciones obtenidas con el telescopio de 2.15 m. del CASLEO (San Juan). El estudio de la naturaleza del sistema se realizó a través del análisis de algunos espectros reunidos entre los años 1990 y 1995 y de datos polarimétricos correspondientes al intervalo 1995 y 1997. El análisis espectroscópico indica que AR Pav está compuesta por una gigante roja M3.7 y una componente caliente compacta, con una temperatura mayor a 90000 K y una luminosidad del orden de 500Lsolar. A lo largo del período orbital, las variaciones observadas en flujo y en velocidades radiales, reflejan que las emisiones permitidas se forman en una región que rodea la componente caliente. El estudio de la polarización lineal de AR Pav indica que además de una componente interestelar, existe una componente intrínseca del sistema que varía temporalmente y con la longitud de onda de la luz polarizada. El distinto comportamiento del grado de polarización y del ángulo de posición observado en fases diferentes, sugiere que distintos mecanismos pueden estar actuando, dependiendo de la región de scattering observado a lo largo de la línea de la visual.

  3. Procesamiento Digital de Imagenes del Cometa Halley

    NASA Astrophysics Data System (ADS)

    Ferrin, L.; Fuenmayor, F.; Naranjo, O.; Bulka, P.; Mendoza, C.

    1987-05-01

    Se reportan observaciones fotográficas del cometa Halley, obtenidas con los telescopios Schmidt de 1-m del CIDA, y de 35 cms de la ULA. Se hicieron exposiciones desde 2 segundos a 30 minutos y se utilizaron emulsiones IIa-O, 103a-F, y 103a-D, guladas manualmente 0 automaticámente. Las imágenes fueron digitalizadas con el microdensitómetro PDS, y procesadas con el sistema HACIENDA del CCIBM. Se experimentó con la Transformada de Fourier en dos dimensiones, y con la aplicación de filtros de paso alto y bajo. Se encontró que el metodo de "autocorrelación" es el mejor para separar "la vegetación" de "la montaña". Se aplicaron diversas técnicas a fin de cubrir ambos extremos: a) enfatizar detalles débiles en la cola, y b) penetrar en las regiones más intensas de la coma. Se lograron ambos objetivos. Detalles en la cola permitieron determinar velocidades de propagación de unos 50 a 90 kms/ seg. Se pudieron detectar no menos de tres perturbaciones en "Y", y una en 5? Co de Cisne). Se cree que las primeras están asociadas a eventos de desconexión. Se puede separar la cola de gas de la de polvo. Las fotos de color permiten enfatizar diferentes regiones espectrales con mayor claridad aún. El "balance" del color puede ser hecho con la computadora.

  4. Características del viento en estrellas Be derivadas del perfil Hα

    NASA Astrophysics Data System (ADS)

    Rohrmann, R.; Cidale, L.

    El estudio teórico de perfiles Hα y su variabilidad en estrellas Be ha sido frecuentemente desarrollado en base a modelos de envolturas circunestelares inhomogéneas, donde la geometría del material es responsable de la forma del perfil dependiendo de la dirección de observación. Nosotros damos una interpretación alternativa y proponemos que la mayoría de las propiedades de esta línea tienen origen en la base de un viento estelar y de una estructura cromosférica anexa a la fotósfera. Encontramos que típicos perfiles Hα en Be, como son los llamados pole-on y winebottle, pueden ser reproducidos cualitativamente sin recurrir a la existencia de una envoltura asimétrica. Analizamos como la línea Hα permite identificar la posible estructura del viento en la región donde éste se inicia.

  5. [Use and attitudes about drugs among nursing students at the Universidad Mayor de San Andrés].

    PubMed

    Flores, Iblin Elizabeth Enriquez; Luis, Margarita Antonia Villar

    2004-01-01

    This study presents the results of a research that examined the use and attitudes about alcohol, tobacco, coca leaves, tranquilizers and amphetamines among nursing students at the Universidad Mayor de San Andrés who had not used these substances over the last 12 months. Data were collected in August 2002 by means of a self-administered and distributed questionnaire, which guaranteed anonymity. The following results were obtained: Attitudes related to drugs approve of coca leaf and tranquilizer use and disapprove of cocaine. Personal use of drugs during the last 12 months corresponds to: daily use of coca leaves, alcohol less than once per week and tobacco every day. The main reason for using these drugs is related to religious practice; the students' first contact with drugs occurs through family members and (girl or boy) friends.

  6. Growth of a Structure Connecting the 2010 M 7.2 El Mayor - Cucapah Rupture with the Elsinore Faul

    NASA Astrophysics Data System (ADS)

    Donnellan, A.; Parker, J. W.

    2015-12-01

    The M 7.2 El Mayor - Cucapah earthquake occurred on 4 April 2010 in the northern part of Baja, Mexico. The rupture extended about 120 km from near the northern tip of the Gulf of California to the US - Mexican border south of the Elsinore fault zone. Most of the aftershocks occurred within days of the main event. On 14 June 2010 a M 5.7 late aftershock occurred 8 km southeast of Ocotillo, CA and is the largest aftershock in the sequence. The right-lateral event occurred in a cluster of aftershocks and was followed by its own aftershock sequence. UAVSAR data were collected for a swath covering the aftershock on 13 April, 2010 just after the El Mayor - Cucapah earthquake and before the earthquake on 21 October 2009. The line was reflown 1 July 2010 after the M 5.7 14 June 2010 aftershock. Data have been continued to be collected semi yearly to yearly since then. Repeat Pass Interferomety (RPI) products spanning the aftershock show the growth of a lineament that with an azimuth of 121.5° or a strike of -58.5°. The interferograms suggest that a stepover develops following the earthquake. The epicenter of the M 5.7 aftershock is proximal to the linear discontinuity in the postseismic interferogram and the mechanism of the event is consistent with slip on this stepover. Inversions for slip on the northeast linear structure that steps west of the mainshock rupture yield a moment magnitude ranging from 5.5 - 5.8, which is consistent with the magnitude of the aftershock. Slip occurs at a depth of 2-10 km on a steeply dipping fault.

  7. Mastering Slip Distributions by Minimizing Model Parameterization Errors: A Case Study with the 2010 Sierra El Mayor, Mexico Earthquake

    NASA Astrophysics Data System (ADS)

    Lohman, R. B.; Barnhart, W. D.

    2010-12-01

    Inversions of coseismic slip distributions from geodetic observations provide important information about the spatial distribution and magnitude of slip that can be used in better understanding static stress changes, the nature of slip asperities, and relations of aftershocks to co- and post-seismic processes. A variety of errors, including incorrect fault geometry, improper or simplified rigidity structure, and noise are propagated into slip distributions leading to incorrect assumptions when using these models to drive further modeling. In this work, we explore the potential to understand model parameterization errors by constraining the model geometry through a variety of means. We use the 2010 April 4 Sierra El Mayor earthquake as a case study due to the abundance of geological and geodetic observations of the rupture and local faults. We begin by exploring very simple, planar fault geometries to demonstrate errors associated with oversimplification. We then use digitized fault traces from geologic maps and literature to demonstrate errors that may be propagated into the slip distributions by assuming an incorrect fault location or fault strand. We also use fault traces digitized from deformation maps derived through pixel tracking offsets in SAR scenes to derive a model geometry. This technique allows us the best constraint on the actual surface rupture location without going into the field, but does not necessarily provide strong constraints on the fault geometry at depth. We explore the potential modeling errors associated with deeper portions of the fault through the use of a synthetic scenario similar to the Sierra El Mayor earthquake. In addition to variable fault geometries, we also demonstrate how variable model dislocation sizes can allow for parameterization of complicated surface fault traces without introducing unresolved resolution at depth.

  8. Systematic Study of Foreshocks and Triggered Earthquakes During the 2010 Mw7.2 El Mayor-Cucapah Earthquake Sequence

    NASA Astrophysics Data System (ADS)

    Meng, X.; Peng, Z.; Deng, S.; Castro, R. R.

    2015-12-01

    The 2010 Mw7.2 El Mayor-Cucapah earthquake occurred southwest of the Pacific-North America plate boundary in north Baja California. It was preceded by an intensive foreshock sequence, and was followed by numerous aftershocks both on and off the mainshock rupture zone, hence providing us a great opportunity to study the physical mechanisms of foreshock and aftershock triggering. In our previously published work (Meng and Peng, GJI, 2014), we focused on the seismicity rate changes around the Salton Sea Geothermal Field (SSGF) and along the San Jacinto Fault (SJF) following the mainshock. Based on a recently developed matched filter technique, we were able to detect up to 20 times more events than listed in the SCSN catalog. We found that the seismicity rate near SSGF and SJF both experienced significant increase immediately following the mainshock. However, the seismicity rate near SSGF, where static Coulomb stress decreased, dropped below the pre-mainshock level after ~50 days. On the other hand, the seismicity rate near SJF, where static Coulomb stress increased, remained high till the end of our detecting time window. Such pattern indicates that both static and dynamic triggering may coexist, but dominate in different time scales. Motivated by this success, we shift our focus to the foreshock and aftershock sequence of the El Mayor-Cucapah event. We utilize available seismic stations immediately north to US-Mexico boarder and a few stations within Mexico to conduct a similar detection ~40 days before to 40 days after the mainshock. We aim to obtain a complete foreshock sequence and investigate its spatio-temporal evolutions before the mainshock. Moreover, we plan to study similar patterns for aftershocks and the corresponding triggering mechanisms. Updated results will be presented at the meeting.

  9. Factores socio-económicos asociados a la percepción de situación socioeconómica entre adultos mayores de dos países latinoamericanos

    PubMed Central

    Brenes-Camacho, Gilbert

    2014-01-01

    El objetivo principal del artículo es estudiar la asociación entre la percepción subjetiva sobre la situación económica propia y una serie de medidas objetivas de bienestar socioeconómico –fuentes de ingresos, tenencia de vivienda, nivel educativo y transferencias familiares informales de dinero- entre adultos mayores de dos países Latinoamericanos: México y Costa Rica. Los datos se obtienen de las primeras rondas de dos encuestas sobre envejecimiento: CRELES para Costa Rica y ENASEM para México. La variable dependiente más importante se obtiene de las respuestas a las pregunta “¿Cómo califica su situación económica actual?” en Costa Rica y “¿Diría usted que su situación económica es…?” en México. Para ambas encuestas, las respuestas se codificaron en forma binaria; el código 0 representa las categorías Excelente, Muy buena y Buena, y el código 1 representa a las categorías Regular y Mala. Se encontró que el ingreso por jubilación es un importante determinante de la percepción de bienestar en ambos países. En Costa Rica, el ingreso del cónyuge y la tenencia de vivienda son importantes predictores de la percepción de bienestar, mientras que en México, los ingresos por transferencias están fuertemente asociados con dicha percepción. PMID:25360057

  10. Grading the Mayor

    ERIC Educational Resources Information Center

    Gewertz, Catherine

    2005-01-01

    In the shadow of a Manhattan housing project, Public School 33 is coming back to life. A new principal has brought a wave of optimism, test scores are way up, and middle-class families who used to avoid the school are enrolling their children. In Brooklyn, teenagers who might have dropped out of school are getting diplomas through a special…

  11. Liquefaction and other ground failures in Imperial County, California, from the April 4, 2010, El Mayor-Cucapah earthquake

    USGS Publications Warehouse

    McCrink, Timothy P.; Pridmore, Cynthia L.; Tinsley, John C.; Sickler, Robert R.; Brandenberg, Scott J.; Stewart, Jonathan P.

    2011-01-01

    The Colorado River Delta region of southern Imperial Valley, California, and Mexicali Valley, Baja California, is a tectonically dynamic area characterized by numerous active faults and frequent large seismic events. Significant earthquakes that have been accompanied by surface fault rupture and/or soil liquefaction occurred in this region in 1892 (M7.1), 1915 (M6.3; M7.1), 1930 (M5.7), 1940 (M6.9), 1950 (M5.4), 1957 (M5.2), 1968 (6.5), 1979 (6.4), 1980 (M6.1), 1981 (M5.8), and 1987 (M6.2; M6.8). Following this trend, the M7.2 El Mayor-Cucapah earthquake of April 4, 2010, ruptured approximately 120 kilometers along several known faults in Baja California. Liquefaction caused by the M7.2 El Mayor-Cucapah earthquake was widespread throughout the southern Imperial Valley but concentrated in the southwest corner of the valley, southwest of the city centers of Calexico and El Centro where ground motions were highest. Although there are few strong motion recordings in the very western part of the area, the recordings that do exist indicate that ground motions were on the order of 0.3 to 0.6g where the majority of liquefaction occurrences were found. More distant liquefaction occurrences, at Fites Road southwest of Brawley and along Rosita Canal northwest of Holtville were triggered where ground motions were about 0.2 g. Damage to roads was associated mainly with liquefaction of sandy river deposits beneath bridge approach fills, and in some cases liquefaction within the fills. Liquefaction damage to canal and drain levees was not always accompanied by vented sand, but the nature of the damage leads the authors to infer that liquefaction was involved in the majority of observed cases. Liquefaction-related damage to several public facilities - Calexico Waste Water Treatment Plant, Fig Lagoon levee system, and Sunbeam Lake Dam in particular - appears to be extensive. The cost to repair these facilities to prevent future liquefaction damage will likely be prohibitive. As

  12. Triggered Fault Slip in Southern California Associated with the 2010 Sierra El Mayor-Cucapah, Baja California, Mexico, Earthquake

    NASA Astrophysics Data System (ADS)

    Rymer, M. J.; Treiman, J. A.; Kendrick, K. J.; Lienkaemper, J. J.; Wei, M.; Weldon, R. J.; Bilham, R. G.; Fielding, E. J.

    2010-12-01

    Surface fracturing (triggered slip) occurred in the central Salton Trough and to the southwest, in the Yuha Desert area—all in association with the 4 April 2010 (M7.2) El Mayor-Cucapah earthquake and its aftershocks. Triggered slip in the central Salton Trough occurred on the ‘frequent movers’: the southern San Andreas, Coyote Creek, Superstition Hills, and Imperial Faults, all of which have slipped in previous moderate to large, local and regional earthquakes in the past five decades. Other faults in the central Salton Trough that also slipped in 2010 include the Wienert Fault (southeastern section of the Superstition Hills Fault), the Kalin Fault (in the Brawley Seismic Zone), and the Brawley Fault Zone; triggered slip had not been reported on these faults in the past. Geologic measures of slip on faults in the central Salton Trough ranged from 1 to 18 mm, and everywhere was located where previous primary (tectonic) or triggered slip has occurred. Triggered slip in the Yuha Desert area occurred along at least two dozen faults, only some of which were known before the 4 April 2010 El Mayor-Cucapah earthquake. From east to northwest, slip occurred in seven general areas; 1) in the Northern Centinela Fault Zone (newly named), 2) along unnamed faults south of Pinto Wash, 3) along the Yuha Fault (newly named), 4) along both east and west branches of the Laguna Salada Fault, 5) along the Yuha Well Fault Zone (newly revised name), 6) along the Ocotillo Fault (newly named), and 7) along the southeastern-most section of the Elsinore Fault. Faults that slipped in the Yuha Desert area include northwest-trending right-lateral faults, northeast-trending left-lateral faults, and north-south faults, some of which had dominantly vertical slip. Triggered slip along the Ocotillo and Elsinore Faults occurred only in association with the 14 June 2010 (M5.7) aftershock, which also initiated slip along other faults near the town of Ocotillo. Triggered slip on faults in the Yuha

  13. Differentiating static and dynamic triggering near Salton Sea following the 2010 Mw7.2 El Mayor-Cucapah earthquake

    NASA Astrophysics Data System (ADS)

    Meng, X.; Peng, Z.; Zhao, P.

    2011-12-01

    Whether static or dynamic triggering is the dominant mechanism for triggering aftershocks in near field is currently under heated debate. Previous studies on earthquake triggering mostly examined seismicity rate changes around the occurrence time of large earthquakes based on existing earthquake catalogs. However, such catalogs could be incomplete immediately after the mainshock, which may cause apparent seismicity rate changes that are unrelated to stress changes. In this study, we examine seismicity rate changes around the Salton Sea geothermal region following the 2010 Mw7.2 El Mayor-Cucapah earthquake in Baja California. We focus on this region mainly because of its abundant background seismicity, dense network coverage, and being in the apparent stress shadow of the mainshock, which is the key factor to differentiate static and dynamic triggering. According to the Southern California Seismic Network (SCSN) catalog, the seismicity rate near Salton Sea clearly increased immediately after the mainshock and dropped below the pre-mainshock level within a few days. The seismicity remains low for another few months before returning back to the pre-mainshock level. To check whether such patterns are caused by catalog incompleteness, we are currently applying a waveform-based matched filter technique to detect possible missing events around Salton Sea that were masked by rigorous aftershock sequence around the mainshock rupture region. With more completed catalog, we can identify the genuine seismicity rate changes for better comparison with the static and dynamic stress changes. In addition to seismicity rate, static and dynamic stress changes could also affect seismic velocity in the upper crust, with a pattern that is somewhat similar to seismicity rate changes. Thus, monitoring seismic velocity changes can further help to differentiate the triggering mechanisms. In our preliminary study, we apply the ambient noise cross-correlation technique to continuously monitor

  14. El Informe a la Nación sobre el Estado del Cáncer, 1975-2012

    Cancer.gov

    El Informe a la Nación sobre el Estado del Cáncer (1975-2012) indica que continuó la baja de tasas de mortalidad de todos los cánceres juntos, así como de la mayoría de los cánceres en hombres y mujeres de todos los grupos raciales y étnicos principales.

  15. A harmonised dataset of greenhouse gas emissions inventories from cities under the EU Covenant of Mayors initiative

    NASA Astrophysics Data System (ADS)

    Iancu, A.; Martelli, S.; Cerutti, A. K.; Janssens-Maenhout, G.; Melica, G.; Rivas-Calvete, S.; Kona, A.; Zancanella, P.; Bertoldi, P.

    2015-06-01

    The realization of national climate change commitments, as agreed through international negotiations, requires local action. However, data is still insufficient to make accurate statements about the scale of urban emissions (UNHABITAT, 2011). The need of comparable emission inventories at city level, including smaller cities, is widely recognized to develop evidence-based policies accounting for the relation between emissions and institutional, socio-economic and demographic characteristics at city level. This paper presents a collection of harmonized greenhouse gases (GHG) emission inventories (the "CoM sample 2013") at municipal level directly computed by the cities and towns that participate in the EU Covenant of Mayors initiative. This is the mainstream European movement of local and regional authorities who voluntarily commit to reduce GHG emissions by 20 % or more by 2020. The "CoM sample 2013" (http://edgar.jrc.ec.europa.eu/com/data/index.php?SECURE=123, doi:10.2904/EDGARcom2013) has been carefully checked to ensure its internal consistency and its congruity with respect to internationally accepted guide values for emission factors. Overall, it provides valuable data for the analysis of the heterogeneity of final energy consumption and greenhouse gas emissions of cities.

  16. The songs of Tlaloc: Interference of ten ceramical duct flutes, Offering 89 of the Aztec Templo Mayor

    NASA Astrophysics Data System (ADS)

    Both, M. A. Adje

    2002-11-01

    Among the many preserved sound artefacts deposited in the offerings of the Aztec Templo Mayor are a set of ten tubular duct flutes made from clay, dating Late Postclassic Mesoamerica, 1350-1521 AD. The aerophones are completely painted in blue, and characterized by: (1) a short mouthpiece; (2) a framed aperture; (3) a tube with four fingerholes; and (4) an applicated mask with features of the Aztec rain god Tlaloc, basically three rings and a standardized relief structure of two clouds. While all measurements follow the same pattern, one particular organological distinction was made, as five flutes show an exit hole in the middle ring of the mask and five flutes are stopped. Thus, five instruments sound considerably higher, apart from the minimal pitch deviation of each specimen. Both the tonal capacity of each flute and the acoustics of several flutes played simultaneously were recorded and measured. A series of remarkable interference effects could be produced, which were strongly related to the ritual complex reflected in the offering. Taking in consideration the Aztec concept of music, it could be supposed that they were perceived as a principle of the song, or proper voice of Tlaloc.

  17. Aftershocks of the 2010 Mw 7.2 El Mayor-Cucapah earthquake revealcomplex faulting in the Yuha Desert, California

    USGS Publications Warehouse

    Kroll, K.; Cochran, Elizabeth S.; Richards-Dinger, K.; Sumy, Danielle

    2013-01-01

    We detect and precisely locate over 9500 aftershocks that occurred in the Yuha Desert region during a 2 month period following the 4 April 2010 Mw 7.2 El Mayor-Cucapah (EMC) earthquake. Events are relocated using a series of absolute and relative relocation procedures that include Hypoinverse, Velest, and hypoDD. Location errors are reduced to ~40 m horizontally and ~120 m vertically.Aftershock locations reveal a complex pattern of faulting with en echelon fault segments trending toward the northwest, approximately parallel to the North American-Pacific plate boundary and en echelon, conjugate features trending to the northeast. The relocated seismicity is highly correlated with published surface mapping of faults that experienced triggered surface slip in response to the EMC main shock. Aftershocks occurred between 2 km and 11 km depths, consistent with previous studies of seismogenic thickness in the region. Three-dimensional analysis reveals individual and intersecting fault planes that are limited in their along-strike length. These fault planes remain distinct structures at depth, indicative of conjugate faulting, and do not appear to coalesce onto a throughgoing fault segment. We observe a complex spatiotemporal migration of aftershocks, with seismicity that jumps between individual fault segments that are active for only a few days to weeks. Aftershock rates are roughly consistent with the expected earthquake production rates of Dieterich (1994). The conjugate pattern of faulting and nonuniform aftershock migration patterns suggest that strain in the Yuha Desert is being accommodated in a complex manner.

  18. Feature Detection in SAR Interferograms With Missing Data Displays Fault Slip Near El Mayor-Cucapah and South Napa Earthquakes

    NASA Astrophysics Data System (ADS)

    Parker, J. W.; Donnellan, A.; Glasscoe, M. T.; Stough, T.

    2015-12-01

    Edge detection identifies seismic or aseismic fault motion, as demonstrated in repeat-pass inteferograms obtained by the Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) program. But this identification, demonstrated in 2010, was not robust: for best results, it requires a flattened background image, interpolation into missing data (holes) and outliers, and background noise that is either sufficiently small or roughly white Gaussian. Proper treatment of missing data, bursting noise patches, and tiny noise differences at short distances apart from bursts are essential to creating an acceptably reliable method sensitive to small near-surface fractures. Clearly a robust method is needed for machine scanning of the thousands of UAVSAR repeat-pass interferograms for evidence of fault slip, landslides, and other local features: hand-crafted intervention will not do. Effective methods of identifying, removing and filling in bad pixels reveal significant features of surface fractures. A rich network of edges (probably fractures and subsidence) in difference images spanning the South Napa earthquake give way to a simple set of postseismically slipping faults. Coseismic El Mayor-Cucapah interferograms compared to post-seismic difference images show nearly disjoint patterns of surface fractures in California's Sonoran Desert; the combined pattern reveals a network of near-perpendicular, probably conjugate faults not mapped before the earthquake. The current algorithms for UAVSAR interferogram edge detections are shown to be effective in difficult environments, including agricultural (Napa, Imperial Valley) and difficult urban areas (Orange County.).

  19. Efecto del Programa de Entrenamiento “Manejo del Dolor” en la Documentación de Enfermería en el Expediente Electrónico

    PubMed Central

    Monsiváis, María Guadalupe Moreno; Guzmán, Ma. Guadalupe Interial; Flores, Paz Francisco Sauceda; Arreola, Leticia Vázquez

    2012-01-01

    Resumen En el presente trabajo se muestra la importancia de entrenar al personal de enfermería para mejorar la documentación en el expediente electrónico. Se eligió el manejo del dolor por ser un área prioritaria; una alta proporción de pacientes en período post operatorio cursa con dolor, por lo tanto, la documentación debe ser útil para la toma de decisiones clínicas. Se implementó un programa de entrenamiento denominado “Manejo del Dolor” dirigido al personal de enfermería. Se utilizó la tecnología de la información como herramienta para fortalecer el conocimiento con base en la revisión sistemática de la literatura; el personal de enfermería participante seleccionó la mejor evidencia; posteriormente se trabajó en la transferencia de este conocimiento a la práctica a través del diseño de un protocolo para el manejo del dolor. Se concluye que el conocimiento del manejo del dolor es fundamental para que enfermería documente con mayor precisión sus intervenciones. PMID:24199106

  20. Building on Years of Parent and Student Activism to Place a New Education Agenda at the Center of a Mayoral Election

    ERIC Educational Resources Information Center

    Fernández, María C.; Williams, Ocynthia

    2014-01-01

    For over a decade, students and parents in New York City have organized in coalitions across boroughs to fight for an equitable, just school system for all public school students. In a time when the Department of Education (DOE) centralized all power in the hands of one mayor and one schools chancellor, the Urban Youth Collaborative (UYC) and the…

  1. Terrestrial LiDAR analyses of coseismic surface deformation from the 4 April 2010 El Mayor-Cucapa Earthquake (Invited)

    NASA Astrophysics Data System (ADS)

    Gold, P. O.; Elliott, A. J.; Oskin, M. E.; Taylor, M. H.; Herrs, A. J.; Hinojosa, A.; Kreylos, O.; Bernardin, T. S.; Cowgill, E.

    2010-12-01

    High-resolution terrestrial LiDAR (t-LiDAR) datasets collected 12-18 days after the 4 April 2010, Mw7.2 El Mayor-Cucapah earthquake in northern Mexico demonstrate the capability of t-LiDAR to rapidly quantify and preserve details of coseismic surface deformation at high resolution. Though the quantity of equipment required even for highly portable t-LiDAR systems remains a limitation, where data acquisition can be accomplished the resulting cm-resolution topography can uniquely enhance understanding of how earthquakes deform the earth’s surface. Our surveys of the El Mayor-Cucapah surface rupture, totaling ~2 km in length, quantify fresh meter-scale fault scarps, centimeter- to decimeter-scale distributed slip, and striations on the fault face. To visualize and interpret the data, we use the KeckCAVES immersive 3D virtual reality space and a 3D-enabled desktop computer. We emphasize the importance of interacting with the full resolution point data, even when mapping on gridded digital elevation models (DEMs). An important component of our analysis is to manually de-vegetate the point clouds to improve resolution of fine topographic features. Using the point-cloud data, we measured lineations on near-vertical bedrock fault faces. Populations of data from two sites independently resolve two southeast plunging slip-vectors that differ in rake by ~25°. The shallower set of lineations (30±5° rake) closely matches the 34±8° rake of the 2010 slip vector we measured from displaced landforms. Thus, we conclude that the steeper and more poorly preserved set of lineations (55±10° rake) indicate the slip direction in the penultimate surface-rupturing event. To constrain displacement during the previous earthquake, we reconstructed the pre-rupture topography and collected profiles across a prominent paleo-fault scarp. These profiles yield an average throw of 3.3 m, from which we estimate an oblique right-normal displacement during the penultimate event of ~4 m along a

  2. Early postseismic deformation following the 2010 El Mayor-Cucapah earthquake from ALOS PALSAR and campaign GPS data

    NASA Astrophysics Data System (ADS)

    Funning, G. J.; Ryder, I. M.; Floyd, M. A.

    2011-12-01

    The 4 April 2010 M7.2 El Mayor-Cucapah earthquake ruptured approximately 110 km of the plate boundary zone in northern Baja California and southern California, including a previously unmapped section through the Colorado River delta. The event was unusual in that it had a longer rupture length than other recent events of the same magnitude, perhaps a manifestation of crustal thinning in the region, in the transition between transform motion on the San Andreas-Imperial fault system to the northwest and seafloor spreading in the Gulf of California to the southeast. Here we examine the ongoing postseismic deformation that has occurred in the aftermath of the event, using a combination of InSAR and GPS time series. In order to identify the spatial pattern of postseismic deformation, we process the full archive of ALOS PALSAR data held by the Alaska Satellite Facility's USGRC datapool, spanning a nine month interval from April 2010 to January 2011. We supplement these data with campaign GPS measurements made on a series of post-earthquake campaigns in Baja California by researchers from UCR, Scripps Institiute of Oceanography and CICESE, starting one day after the event. Preliminary indications suggest that the first year of postseismic deformation was marked by i) a narrow zone of ~10 cm of subsidence bounded to the north by the Colorado delta segment of the main fault rupture; ii) a secondary area of initial subsidence located a few kilometers to the northeast of the main subsiding zone that is recovered within ~6 months of the earthquake; iii) near-field right-lateral shear of ~5 cm across the Sierra Cucapah. The first two of these deformation signals are consistent with a combination of transient poroelastic deformation and the third with shallow afterslip. Preliminary models of predicted Maxwell viscoelastic relaxation do not appear to explain this early, rapid deformation.

  3. Triggered surface slips in southern California associated with the 2010 El Mayor-Cucapah, Baja California, Mexico, earthquake

    USGS Publications Warehouse

    Rymer, Michael J.; Treiman, Jerome A.; Kendrick, Katherine J.; Lienkaemper, James J.; Weldon, Ray J.; Bilham, Roger; Wei, Meng; Fielding, Eric J.; Hernandez, Janis L.; Olson, Brian P.E.; Irvine, Pamela J.; Knepprath, Nichole; Sickler, Robert R.; Tong, Xiaopeng; Siem, Martin E.

    2011-01-01

    Triggered slip in the Yuha Desert area occurred along more than two dozen faults, only some of which were recognized before the April 4, 2010, El Mayor-Cucapah earthquake. From east to northwest, slip occurred in seven general areas: (1) in the Northern Centinela Fault Zone (newly named), (2) along unnamed faults south of Pinto Wash, (3) along the Yuha Fault (newly named), (4) along both east and west branches of the Laguna Salada Fault, (5) along the Yuha Well Fault Zone (newly revised name) and related faults between it and the Yuha Fault, (6) along the Ocotillo Fault (newly named) and related faults to the north and south, and (7) along the southeasternmost section of the Elsinore Fault. Faults that slipped in the Yuha Desert area include northwest-trending right-lateral faults, northeast-trending left-lateral faults, and north-south faults, some of which had dominantly vertical offset. Triggered slip along the Ocotillo and Elsinore Faults appears to have occurred only in association with the June 14, 2010 (Mw5.7), aftershock. This aftershock also resulted in slip along other faults near the town of Ocotillo. Triggered offset on faults in the Yuha Desert area was mostly less than 20 mm, with three significant exceptions, including slip of about 50–60 mm on the Yuha Fault, 40 mm on a fault south of Pinto Wash, and about 85 mm on the Ocotillo Fault. All triggered slips in the Yuha Desert area occurred along preexisting faults, whether previously recognized or not.

  4. Preguntas y respuestas acerca del Estudio del

    Cancer.gov

    El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en ingls) es un estudio clnico (un estudio de investigacin conducido con voluntarios) diseado para ver cómo el medicamento raloxifeno (Evista) se compara con el medicamento tamoxifeno (Nolvadex)

  5. Airborne and terrestrial lidar imaging and analysis of the 4 April 2010 El Mayor-Cucapah earthquake rupture

    NASA Astrophysics Data System (ADS)

    Oskin, M. E.; Gold, P. O.; Hinojosa, A.; Arrowsmith, R.; Elliott, A. J.; Taylor, M. H.; Herrs, A. J.; Sartori, M.; Gonzalez-Garcia, J. J.; Gonzalez, A.; Kreylos, O.; Cowgill, E.

    2010-12-01

    We report newly available data sets and preliminary analysis of ground- and airborne-lidar surveys of the 4 April 2010 El Mayor-Cucapah earthquake rupture. The hyperarid setting and varied surficial geology of this complex rupture zone presents an ideal setting to advance the use of lidar in post-earthquake scientific response. Terrestrial lidar surveys commenced within two weeks of the earthquake and capture ephemeral geomorphic features of the rupture zone. We recorded approximately 2 km of rupture on the Borrego fault where oblique dextral slip approaches four meters. These data highlight fine-scale features such as centimeter-scale scarps, subtle warping of the ground surface, and striations on the exposed fault free-face. Airborne lidar surveys, collected mid-August, 2010, span the rupture zone for 100 km in a NW-SE direction, from just south of the international border to the tidal flats of the Colorado River delta at the head of the Gulf of California. 3.8 billion point measurements were obtained with an average density of 11 points per square meter. GPS ground control was provided from a combination of PBO stations north of the border and coordination with the occupation of post-earthquake campaign sites in the central and southern portions of the rupture zone. The 3 km average width of the survey captures the complexity of strain-transfer between the multiple fault segments that slipped in 2010, as well as the adjacent zone of surface ruptures attributed to the 1892 Laguna Salada earthquake. This data set provides a new basis for offset measurements to be compared against field data collected immediately following the 2010 earthquake. Quantitative comparison to lower-resolution, pre-event lidar collected by the Instituto Nacional de Estadística y Geografía (INEGI) illuminates near-field distributed vertical deformation adjacent to the fault rupture. The southeastern half of the lidar survey spans a zone of cryptic dextral deformation, hosted within the

  6. Determinacion de Caracteristicas Opticas del Telescopio OAN150

    NASA Astrophysics Data System (ADS)

    Galan, M. J.; Cobos, F. J.

    1987-05-01

    En el Observatorio de Calar Alto, en Almería, España, está ubicado un telescopio de 15O-cms de diámetro -construído por REOSC- perteneciente al Observatorio Astronómico Nacional, con sede en Madrid, España. La infraestructura técnica del OAN ha sido tradicionalmente débil y actualmente se está haciendo un esfuerzo por fortalecerla. Existe una información muy limitada del telescopio en general; de su óptica en particular se conocían los valores de los parámetros principales pero sin saber si éstos corresponden a valores teóricos ó de construcción. Por ello se consideró necesario iniciar una investigación para conocer en detalle los valores reales de las componentes ópticas del telescopio, obteniéndose algunos resultados de interés. El primario del telescopio OANl5O es aproximadamente F/3 y el siste ma en su conjunto es F/8.2, con su sistema corrector de campo. En términos generales, la imagen es satisfactoria en todo el campo y, sin sistema corrector, la imagen axial también es buena. En un futuro muy cercano se piensa diseñar instrumentación adicional para este telescopio. Conocer con mayor precisión sus características puede ser de gran utilidad para tal fin, pues se efectúan los cálculos considerando conjuntamente al telescopio y al instrumento.

  7. Estrategia innovadora enfocada en parejas del mismo sexo para disminuir la infección del VIH en hombres Latinos

    PubMed Central

    Martinez, Omar; Wu, Elwin; Sandfort, Theo; Shultz, Andrew Z.; Capote, Jonathan; Chávez, Silvia; Moya, Eva; Dodge, Brian; Morales, Gabriel; Porras, Antonio; Ovejero, Hugo

    2014-01-01

    Resumen El VIH es un problema de salud importante dentro de la comunidad latina de los Estados Unidos. Gracias a los esfuerzos de prevención, los niveles de contagio entre los latinos se han mantenido estables por más de una década. Sin embargo, esta población sigue siendo afectada a niveles muy altos, en particular entre hombres que tienen sexo con hombres (HSH), de origen latino y que hablan principalmente el idioma español. Existen varios factores que contribuyen a la transmisión del VIH entre esta población, como son: el uso de drogas; la violencia dentro de la pareja; la presencia de infecciones de transmisión sexual; relaciones sexuales sin protección, dentro y fuera de la pareja; el evadir la búsqueda de recursos (prueba y tratamiento adecuado) por temor a ser discriminado o por su estatus migratorio; la escasez de recursos económicos o estado de pobreza y los patrones relacionados a la migración. En particular, Investigaciones Epidemiológicas de Comportamientos han determinado: cómo algunas dinámicas en parejas están directamente asociadas a los comportamientos sexuales de riesgos. En consecuencia, es necesaria mayor investigación para identificar esas dinámicas, y a su vez, realizar intervenciones dirigidas a la reducción de conductas de riesgo enfocadas en parejas de hombres del mismo sexo. En este escrito, se describe la importancia del uso de las relaciones de pareja como estrategia en la reducción de la trasmisión del VIH/SIDA en HSH de origen latino y que hablan principalmente el idioma español en los Estados Unidos. PMID:25580466

  8. Mini-mastoidectomía para anastomosis hipogloso-facial con sección parcial del nervio hipogloso

    PubMed Central

    Campero, Álvaro; Ajler, Pablo; Socolovsky, Mariano; Martins, Carolina; Rhoton, Albert

    2012-01-01

    Introducción: La anastomosis hipogloso-facial es la técnica de elección para la reparación de la parálisis facial cuando no se dispone de un cabo proximal sano del nervio facial. La técnica de anastomosis mediante fresado mastoideo y sección parcial del hipogloso minimiza la atrofia lingual sin sacrificar resultados a nivel facial. Método: La porción mastoidea del nervio facial transcurre por la pared anterior de la AM, a un promedio de 18+/-3 mm de profundidad respecto de la pared lateral. Se debe reconocer la cresta supramastoidea, desde la cual se marca una línea vertical paralela al eje mayor de la AM, 1 cm por detrás de la pared posterior del CAE El fresado se comienza desde la línea medio mastoidea hasta la pared posterior del CAE. Una vez encontrado el nervio facial en el tercio medio del canal mastoideo, el mismo es seguido hacia proximal y distal. Resultados: El abordaje descripto permite acceder al nervio facial intratemporal en su porción mastoidea, y efectuar un fresado óseo sin poner en riesgo al nervio o a estructuras vasculares cercanas. Se trata de un procedimiento técnicamente más sencillo que los abordajes amplios habitualmente utilizados al hueso temporal; no obstante su uso debe ser restringido mayormente a la anastomosis hipogloso-facial. Conclusión: Esta es una técnica relativamente sencilla, que puede ser reproducida por cirujanos sin mayor experiencia en el tema, luego de su paso por el laboratorio de anatomía. PMID:23596555

  9. Estudio del CH interestelar

    NASA Astrophysics Data System (ADS)

    Olano, C.; Lemarchand, G.; Sanz, A. J.; Bava, J. A.

    El objetivo principal de este proyecto consiste en el estudio de la distribución y abundancia del CH en nubes interestelares a través de la observación de las líneas hiperfinas del CH en 3,3 GHz. El CH es una molécula de amplia distribución en el espacio interestelar y una de las pocas especies que han sido observadas tanto con técnicas de radio como ópticas. Desde el punto de vista tecnológico se ha desarrollado un cabezal de receptor que permitirá la realización de observaciones polarimétricas en la frecuencia de 3,3 GHz, con una temperatura del sistema de 60 K y un ancho de banda de 140 MHz, y que será instalado en el foco primario de la antena parabólica del IAR. El cabezal del receptor es capaz de detectar señales polarizadas, separando las componentes de polarización circular derecha e izquierda. Para tal fin el cabezal consta de dos ramas receptoras que amplificarán la señal y la trasladarán a una frecuencia más baja (frecuencia intermedia), permitiendo de esa forma un mejor transporte de la señal a la sala de control para su posterior procesamiento. El receptor además de tener características polarimétricas, podrá ser usado en el continuo y en la línea, utilizando las ventajas observacionales y de procesamiento de señal que actualmente posee el IAR.

  10. The Del Rio ataxite, Texas

    NASA Technical Reports Server (NTRS)

    Henderson, E. P.; King, E. A.

    1977-01-01

    Basic data are presented on the Del Rio, Nordheim, and Monahans ataxites found in Texas. Results are reported for bulk-chemistry analysis, metallographic observations, and electron-microprobe analysis of the Del Rio meteorite. It is shown that Del Rio is distinctly different from the other two ataxites in terms of nickel, phosphorous, and carbon content, and is composed of at least three coarse grains in different crystallographic orientations. All the kamacite in Del Rio is found to have transformation structures that are probable shock products, and minor inclusions of daubreelite, schreibersite, and troilite are observed. It is concluded that Del Rio was apparently mildly shocked prior to its fall.

  11. Distribución espacial de cúmulos y asociaciones estelares con diferentes edades en la Nube Mayor de Magallanes

    NASA Astrophysics Data System (ADS)

    Bica, E.; Clariá, J. J.; Dottori, H.; Santos, J. F. C.; Piatti, A. E.

    Sobre la base de observaciones realizadas en Cerro Tololo y el Casleo, se presenta un catálogo con fotometría UBV integrada de 504 cúmulos y 120 asociaciones estelares en la Nube Mayor de Magallanes. Se determinan edades en términos de los tipos SWB y se identifican 38 cúmulos tipo VII, muchos de los cuales pueden ser cúmulos globulares clásicos. El tamaño de las distribuciones espaciales crece uniformemente con la edad (tipo SWB), en tanto que existe una diferencia en el cociente axial entre los grupos más jóvenes y más viejos que 30 millones de años, lo que implica una orientación aproximadamente de frente para los primeros y una posición inclinada ~ 45o para el segundo grupo. Las asimetrías en las distribuciones espaciales, juntamente con la falta de coincidencia de los centroides de los diferentes grupos de edad, sugiere que el disco de la Nube Mayor de Magallanes fue severamente perturbado en el pasado.

  12. The M7.2 2010 El-Mayor-Cucapah Earthquake: How much of the Complexity Can We Explain With Our Models?

    NASA Astrophysics Data System (ADS)

    Kyriakopoulos, C.; Funning, G.; Oglesby, D. D.; Fletcher, J. M.; Ryan, K. J.

    2015-12-01

    The 2010 El Mayor-Cucapah earthquake is one of the most complex multi-segment events ever documented in the Pacific-North America plate boundary zone, rupturing at least seven distinct segments, some of which were previously unknown. An important question for both earthquake physics and seismic hazard analysis of other complex fault systems is whether this earthquake's complex rupture and slip pattern can be reproduced and explained with dynamic rupture models. In particular, what details of the fault geometry and of the pre-event fault stress distribution are required to allow such a rupture, with multiple stepovers and changes in dip and strike, to take place? We perform 3D Finite Element (FE) modeling of this event using realistic fault geometry and topography, and explore the effects of geometry, frictional properties, and stress assumptions on the ability to reproduce observed features of this earthquake. These models are part of a larger project that combines a 3D geodetic model of the El Mayor-Cucapah event with dynamic rupture models that are designed to match this inverted slip distribution. By combining observations with dynamic modeling in an iterative fashion, we are able to produce physically-reasonable models that match primary observations of this event.

  13. Cambios históricos en el aporte terrígeno de la cuenca del Río de la Plata sobre la plataforma interna Uruguaya

    NASA Astrophysics Data System (ADS)

    Marrero, Analía; Tudurí, Adriana; Pérez, Laura; Cuña, Caroline; Muniz, Pablo; Lopes Figueira, Rubens; Michaelovitch de Mahiques, Michel; Alves de Lima Ferreira, Paulo; Pittauerová, Daniela; Hanebuth, Till; García Rodríguez, Felipe

    2014-12-01

    El Río de la Plata (RdlP) presenta significativas variaciones naturales (hidrodinámicas y oceanográficas) asociadas a diferentes condiciones climáticas. El propósito de este trabajo es inferir los cambios de aportes continentales de sedimentos y su relación con las variaciones hidrológicas del Río de la Plata, a través del análisis de proxies sedimentológicos y geoquímicos en testigos de sedimentos de la plataforma interna uruguaya que registran los últimos 100 años, aproximadamente. A partir de la datación por 210Pb de dos testigos de sedimentos (GeoB 13813-4 y BAR1) se reconstruyó la geocronología del ambiente, y se relacionó con datos de las forzantes climáticas Pacific Decadal Oscillation, El Niño/La Niña Southern Oscillation, Atlantic Multidecadal Oscillation, y las anomalías hidrológicas de los ríos Paraná y Uruguay. Los valores más positivos y estables del Southern Oscillation Index, los cuales corresponden a fases La Niña, se observan en el periodo correspondiente entre 1910-1970, respecto al resto de la serie, donde se aprecia una mayor variabilidad y una tendencia hacia valores más negativos (eventos El Niño). Se hicieron dendrogramas (clustering) jerárquicos para ambos testigos. Para el testigo GeoB 13813-4, se utilizó la relación Ca/Ti y la granulometría, mientras que para BAR1 se recurrió a variables granulométricas y la tasa de sedimentación. El mayor aporte continental hacia la región de la plataforma adyacente al Río de la Plata registrado a partir del año 1970, podría ser el factor principal de los agrupamientos observados en los clusters para ambos testigos. Las agrupaciones mostraron una diferenciación en la década de 1970, lo que estaría asociado al aumento de los caudales de los ríos Paraná y Uruguay, durante las últimas tres décadas del siglo XX. Por otra parte se observa que la granulometría del testigo BAR1 presentó un mayor tamaño de grano y más variabilidad que en el caso del testigo Geo

  14. Nevado del Huila, Columbia

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Nevado del Huila Volcano in Colombia is actually a volcanic chain running north to south, capped by a glacier. With peaks ranging in height from 2,600 to 5,780 meters (8,530 to 18,960 feet), Nevado del Huila is a stratovolcano composed of alternating layers of hardened lava, solidified ash, and volcanic rocks. Its first recorded eruption occurred in the mid-sixteenth century. The long-dormant volcano erupted again in mid-April 2007. A few months before the eruption, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite captured this image of Nevado del Huila, on February 23, 2007. In this image, the bright white area just east of the central summit is ice. Immediately west of the summit are bare rocks, appearing as blue-gray. West of those rocks, white reappears, but this patch of white results from clouds hovering in the nearby valley. In the east, the colors turn to brown (indicating bare rock) and bright green (indicating vegetation). ASTER photographed Nevado del Huila near the end of a long phase of quietude. On April 17, 2007, local authorities recorded seismic activity associated with rock fracturing on the volcano's central summit, according to the ReliefWeb Website. Activity intensified the following day with an eruption and mudflows, forcing thousands of nearby residents to evacuate. As the Associated Press reported, the eruption caused avalanches and floods that wiped away both houses and bridges. It marked the volcano's first recorded eruption since the Spanish colonized the area five centuries earlier. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

  15. [Bibliometric analysis of Revista Médica del IMSS in the Scopus database for the period between 2005-2013].

    PubMed

    García-Gómez, Francisco; Ramírez-Méndez, Fernando

    2015-01-01

    Objetivo: analizar la visibilidad de la Revista Médica del Instituto Mexicano del Seguro Social (Rev Med Inst Mex Seguro Soc) en la base de datos Scopus y describir los principales indicadores bibliométricos cuantitativos de la producción científica publicados durante el periodo 2005-2013. Métodos: para el análisis se utilizó la base de datos Scopus y se limitó el periodo de búsqueda a los años 2005-2013. La estrategia de búsqueda se ejecutó en los campos específicos de Título de la Publicación (Source Title) con el término Revista Médica del Instituto Mexicano del Seguro Social y sus posibles variantes, asícomo el número ISSN de la revista. Para el análisis de los datos obtenidos se utilizaron las herramientas de Scopus y los programas Excel y Access. Resultados: se encontraron 864 trabajos publicados durante el periodo 2005-2013 que fueron incluidos en Scopus. Se identificaron los autores con mayor producción científica y mayor número de citas acumuladas a sus trabajos, asícomo las principales revistas que citan a la Rev Med Inst Mex Seguro Soc. Se describen las principales áreas temáticas, tipos de documentos y otros indicadores bibliométricos que caracterizan a la publicación. Conclusiones: el uso de Scopus brinda la posibilidad de analizar con una herramienta externa al IMSS la visibilidad de la producción científica publicada en la Revista Médica del IMSS, además de que contribuye a identificar el estado de la ciencia en México y de los países en vías desarrollo.

  16. [Knowledge on drugs phenomenon by students and faculty from the Medical School at Universidad Mayor de San Andrés, La Paz, Bolivia].

    PubMed

    Navia-Bueno, Maria del Pilar; Farah-Bravo, Jacqueline; Yaksic-Feraudy, Nina; Philco-Lima, Patrícia; Takayanagui, Angela Maria Magosso

    2011-06-01

    The goal of this study was to identify the degree of knowledge of students and health educators on licit and illicit drugs, related to the type, classification, action, mechanisms damages, consequences and adverse effects, besides use and consumption. A cross-sectional methodological design was used, with a sample of 172 students, professors and residents in medicine and nursing at Universidad Mayor de San Andrés (UMSA), Bolivia. The results reveal weak knowledge on the classification of psychotropic substances according to structure, chemical property and effects for health, highlighting significant difference with knowledge on licit and illicit drugs use, with high percentages. In conclusion, there is lack of knowledge in all groups studied on licit and illicit drugs regarding the consequences and adverse effects. This confirms the need to improve teaching on this content in health schools.

  17. Mapping 3D fault geometry in earthquakes using high-resolution topography: Examples from the 2010 El Mayor-Cucapah (Mexico) and 2013 Balochistan (Pakistan) earthquakes

    NASA Astrophysics Data System (ADS)

    Zhou, Yu; Walker, Richard T.; Elliott, John R.; Parsons, Barry

    2016-04-01

    Fault dips are usually measured from outcrops in the field or inferred through geodetic or seismological modeling. Here we apply the classic structural geology approach of calculating dip from a fault's 3-D surface trace using recent, high-resolution topography. A test study applied to the 2010 El Mayor-Cucapah earthquake shows very good agreement between our results and those previously determined from field measurements. To obtain a reliable estimate, a fault segment ≥120 m long with a topographic variation ≥15 m is suggested. We then applied this method to the 2013 Balochistan earthquake, getting dips similar to previous estimates. Our dip estimates show a switch from north to south dipping at the southern end of the main trace, which appears to be a response to local extension within a stepover. We suggest that this previously unidentified geometrical complexity may act as the endpoint of earthquake ruptures for the southern end of the Hoshab fault.

  18. Atlas del Genoma del Cáncer: Antecedentes

    Cancer.gov

    El Atlas del Genoma del Cáncer es una iniciativa de los Institutos Nacionales de la Salud (NIH) para crear mapas multidimensionales completos de los cambios genómicos clave en los tipos y subtipos principales de cáncer.

  19. Cirugía de los trastornos del comportamiento: el estado del arte

    PubMed Central

    Yampolsky, Claudio; Bendersky, Damián

    2014-01-01

    Introducción: La cirugía de los trastornos del comportamiento (CTC) se está convirtiendo en un tratamiento más común desde el desarrollo de la neuromodulación. Métodos: Este artículo es una revisión no sistemática de la historia, indicaciones actuales, técnicas y blancos quirúrgicos de la CTC. Dividimos su historia en 3 eras: la primera comienza en los inicios de la psicocirugía y termina con el desarrollo de las tícnicas estereotácticas, cuando comienza la segunda era. Ésta se caracteriza por la realización de lesiones estereotácticas. Nos encontramos transitando la tercera era, que comienza cuando la estimulación cerebral profunda (ECP) comienza a ser usada en CTC. Resultados: A pesar de los errores graves cometidos en el pasado, hoy en día, la CTC está renaciendo. Los trastornos psiquiátricos que se más frecuentemente se tratan con cirugía son: depresión refractaria, trastorno obsesivo-compulsivo y síndrome de Tourette. Además, algunos pacientes con agresividad fueron tratados quirúrgicamente. Hay varios blancos estereotácticos descriptos para estos trastornos. La estimulación vagal puede ser usada también para depresión. Conclusión: Los resultados de la ECP en estos trastornos parecen alentadores. Sin embargo, se necesitan más estudios randomizados para establecer la efectividad de la CTC. Debe tenerse en cuenta que una apropiada selección de pacientes nos ayudará a realizar un procedimiento más seguro así como también a lograr mejores resultados quirúrgicos, conduciendo a la CTC a ser más aceptada por psiquiatras, pacientes y sus familias. Se necesita mayor investigación en varios temas como: fisiopatología de los trastornos del comportamiento, indicaciones de CTC y nuevos blancos quirúrgicos. PMID:25165612

  20. Static Rupture Model of the 2010 M7.2 El Mayor-Cucapah Earthquake from ALOS, ENVISAT, SPOT and GPS Data

    NASA Astrophysics Data System (ADS)

    Fialko, Y.; Gonzalez, A.; Gonzalez-Garcia, J. J.; Barbot, S.; Leprince, S.; Sandwell, D. T.; Agnew, D. C.

    2010-12-01

    The April 4, 2010 "Easter Sunday" earthquake on the US-Mexico border was the largest event to strike Southern California in the last 18 years. The earthquake occurred on a northwest trending fault close to, but not coincident with the identified 1892 Laguna Salada rupture. We investigate coseismic deformation due to the 2010 El Mayor-Cucapah earthquake using Synthetic Aperture Radar (SAR) imagery form ENVISAT and ALOS satellites, optical imagery from SPOT-5 satellite, and continuous and campaign GPS data. The earliest campaign postseismic GPS survey was conducted within days after the earthquake, and provided the near-field cosesmic offsets. Along-track SAR interferograms and amplitude cross-correlation of optical images reveal a relatively simple continuous fault trace with maximum offsets of the order of 3 meters. This is in contrast to the results of geological mapping that portrayed a complex broad zone of distributed faulting. Also, SAR data indicate that the rupture propagated bi-laterally from the epicenter near the town of Durango both to the North-West into the Cucapah mountains and to the South-East into the Mexically valley. The inferred South-East part of the rupture was subsequently field-checked and associated with several fresh scarps, although overall the earthquake fault does not have a conspicuous surface trace South-East of the hypocenter. It is worth noting that the 2010 earthquake propagated into stress shadows of prior events - the Laguna Salada earthquake that ruptured the North-West part of the fault in 1892, and several M6+ earthquakes that ruptured the South-East part of the fault over the last century. Analysis of the coseismic displacement field at the Earth's surface (in particular, the full 3-component displacement field retrieved from SAR and optical imagery) shows a pronounced asymmetry in horizontal displacements across both nodal planes. The maximum displacements are observed in the North-Eastern and South-Western quadrants. This

  1. Yeast DEL assay detects clastogens.

    PubMed

    Kirpnick, Zhanna; Homiski, Michael; Rubitski, Elizabeth; Repnevskaya, Marina; Howlett, Niall; Aubrecht, Jiri; Schiestl, Robert H

    2005-04-01

    Chromosomal rearrangements, including DNA deletions are involved in carcinogenesis. The deletion (DEL) assay scoring for DNA deletions in the yeast Saccharomyces cerevisiae is able to detect a wide range of carcinogens. Among approximately 60 compounds of known carcinogenic activity, the DEL assay detected 86% correctly whereas the Ames Salmonella assay detected only 30% correctly [R.J. Brennan, R.H. Schiestl, Detecting carcinogens with the yeast DEL assay, Methods Mol. Biol. 262 (2004) 111-124]. Since the DEL assay is highly inducible by DNA double strand breaks, this study examined the utility of the DEL assay for detecting clastogens. Ten model compounds, with varied mechanisms of genotoxicity, were examined for their effect on the frequency of DNA deletions with the DEL assay. The compounds tested were: actinomycin D, camptothecin, methotrexate and 5-fluorodeoxyuridine, which are anticancer agents, noscapine and furosemide are therapeutics, acridine, methyl acrylate and resorcinol are industrial chemicals and diazinon is an insecticide. The in vitro micronucleus assay (IVMN) in CHO cells, a commonly used tool for detection of clastogens, was performed on the same compounds and the results of the two assays were compared. The results of our study show that there is 70% concordance in the presence of metabolic activation (rat liver S9) and 80% concordance in the absence of metabolic activation between the DEL assay and the standard in vitro micronucleus assay. The lack of cytotoxicity observed for four of the ten compounds examined indicates limited diffusion of lipophilic compounds across the yeast cell wall. Thus, the development of a more permeable yeast tester strain is expected to greatly improve concordance of the DEL assay with the IVMN assay. The yeast DEL assay is inexpensive, amenable to automation and requires less expertise to perform than the IVMN. Thus, it has a strong potential as a robust, fast and economical screen for detecting clastogens in

  2. El diseño final del espectrógrafo de banco (EBASIM) para CASLEO

    NASA Astrophysics Data System (ADS)

    Simmons, J.; Levato, H.

    Utilizando el código de óptica ACCOS V se ha finalizado el diseño del espectrógrafo de banco para CASLEO. En una comunicación anterior habíamos indicado que utilizaríamos un colimador de 150 mm de diámetro con un radio de curvatura de 1540 mm. Para el espejo cámara, que tiene un diámetro de 200 mm, el radio de curvatura es de 1200 mm, ambos radios con una tolerancia no mayor a los 3 mm. En la presente, se informa sobre los detalles finales del cálculo del espectrógrafo que incluye el cómputo para 5 longitudes de onda diferentes y alrededor de 100 rayos. En todos los casos el 75 % de energía está dentro de un diámetro de 13 micrones. El diseño ha sido probado entre 3500 Å hasta 9000 Å con resultados satisfactorios.

  3. Seismicity rate changes in the Salton Sea Geothermal Field and the San Jacinto Fault Zone after the 2010 Mw 7.2 El Mayor-Cucapah earthquake

    NASA Astrophysics Data System (ADS)

    Meng, Xiaofeng; Peng, Zhigang

    2014-06-01

    Whether static or dynamic stress changes play the most important role in triggering earthquakes in the near field is still in debate. Here, we examine the seismicity rate changes in southern California following the 2010 Mw 7.2 El Mayor-Cucapah earthquake. We focus on the Salton Sea Geothermal Field (SSGF) and the San Jacinto Fault Zone (SJFZ) because of high-sensitivity continuous borehole recordings and ample background seismicity. A significant increase in seismic activity is found in both study regions immediately following the main shock. However, near the SSGF where the static Coulomb stress decreased, the seismicity rate dropped below the pre-main-shock rate after ˜1 month. In comparison, along the SJFZ with an increase in the static Coulomb stress, the seismicity rate remained higher than the background rate with several moderate-size earthquakes occurring in the subsequent months. While we cannot completely rule out other mechanisms, these observations are best consistent with a widespread increase in seismicity from dynamic stress changes immediately after the main shock, and longer term seismicity rate changes from static stress changes. Our observation, together with other recent studies, suggests that both static and dynamic stress changes are important in triggering near-field earthquakes, but their affected regions and timescales are different.

  4. Damage from the El Mayor-Cucapah earthquake, April 2010: Why society cannot afford to ignore seismic risks to agricultural regions

    NASA Astrophysics Data System (ADS)

    Stenner, H. D.; Mathieson, E. L.; Okubo, S.; Anderson, R.; Rodriguez C., M. A.

    2010-12-01

    The M7.2 El Mayor-Cucapah earthquake of April 4, 2010 in Mexico’s Baja California caused extensive damage to the agricultural area of Mexicali Valley. The damage included wide-spread liquefaction and lateral spreading which destroyed or damaged irrigation canals. Without water, wheat, alfalfa, and other crops were lost. Fields were cut by fissures and partially buried by massive sand blows. Regional tilting from the earthquake was a serious issue for the gravity-controlled irrigation system. Ruptured canals and groundwater from sand blows flooded fields, roads, and towns. Flooding further damaged crops and brought contamination with it. Fissures and scarps through farm communities cracked buildings; ruptured water, sewer, and other pipelines; and made roads temporarily difficult to pass. Economically, farmers, seasonal farm workers, and agricultural suppliers were affected; reducing their ability to consume the goods and services of businesses unrelated to agriculture. Similar damage was observed in earlier earthquakes over the past 100 years. Society quickly forgets how the earth responds to strong shaking. We hope to provide a vivid portrait of this agricultural disaster so that other farming communities prone to strong seismic shaking may visualize what can happen from their own inevitable future earthquake. Fissure and sand blows southeast of Cucapah, Baja California, April 16, 2010. Heavily damaged irrigation canal northwest of Zacamoto, Baja California, April 15, 2010.

  5. Slip on faults in the Imperial Valley triggered by the 4 April 2010 Mw 7.2 El Mayor-Cucapah earthquake revealed by InSAR

    NASA Astrophysics Data System (ADS)

    Wei, Meng; Sandwell, David; Fialko, Yuri; Bilham, Roger

    2011-01-01

    Radar interferometry (InSAR), field measurements and creepmeters reveal surface slip on multiple faults in the Imperial Valley triggered by the main shock of the 4 April 2010 El Mayor-Cucapah Mw 7.2 earthquake. Co-seismic offsets occurred on the San Andreas, Superstition Hills, Imperial, Elmore Ranch, Wienert, Coyote Creek, Elsinore, Yuha, and several minor faults near the town of Ocotillo at the northern end of the mainshock rupture. We documented right-lateral slip (<40 mm) on northwest-striking faults and left-lateral slip (<40 mm) on southwest-striking faults. Slip occurred on 15-km- and 20-km-long segments of the San Andreas Fault in the Mecca Hills (≤50 mm) and Durmid Hill (≤10 mm) respectively, and on 25 km of the Superstition Hills Fault (≤37 mm). Field measurements of slip on the Superstition Hills Fault agree with InSAR and creepmeter measurements to within a few millimeters. Dislocation models of the InSAR data from the Superstition Hills Fault confirm that creep in this sequence, as in previous slip events, is confined to shallow depths (<3 km).

  6. The Virtual Quake earthquake simulator: a simulation-based forecast of the El Mayor-Cucapah region and evidence of predictability in simulated earthquake sequences

    NASA Astrophysics Data System (ADS)

    Yoder, Mark R.; Schultz, Kasey W.; Heien, Eric M.; Rundle, John B.; Turcotte, Donald L.; Parker, Jay W.; Donnellan, Andrea

    2015-12-01

    In this manuscript, we introduce a framework for developing earthquake forecasts using Virtual Quake (VQ), the generalized successor to the perhaps better known Virtual California (VC) earthquake simulator. We discuss the basic merits and mechanics of the simulator, and we present several statistics of interest for earthquake forecasting. We also show that, though the system as a whole (in aggregate) behaves quite randomly, (simulated) earthquake sequences limited to specific fault sections exhibit measurable predictability in the form of increasing seismicity precursory to large m > 7 earthquakes. In order to quantify this, we develop an alert-based forecasting metric, and show that it exhibits significant information gain compared to random forecasts. We also discuss the long-standing question of activation versus quiescent type earthquake triggering. We show that VQ exhibits both behaviours separately for independent fault sections; some fault sections exhibit activation type triggering, while others are better characterized by quiescent type triggering. We discuss these aspects of VQ specifically with respect to faults in the Salton Basin and near the El Mayor-Cucapah region in southern California, USA and northern Baja California Norte, Mexico.

  7. Strategies, Programs and Projects 2008 of the Astrophysical Group "SPACE-Universidad Nacional Mayor De San Marcos, Peru" - Preparing for the IYA2009

    NASA Astrophysics Data System (ADS)

    Vera, Victor; Aguilar, M.; Huisacayna, J.

    2008-05-01

    We present a review of our efforts to introduce astronomy as scientific career in Peru, showing how our astronomy outreach programs have been one of the most important keys to reach our national astronomical scientific goals, remarking the crucial role that the celebration of the IYA2009 must play, in order to promote PhD programmes in astronomy in developing countries. We show the importance of the creation of the Seminario Permanente de Astronomía y Ciencias Espaciales (SPACE) in the Universidad Nacional Mayor de San Marcos, as an academic scientific and cultural center in Peru, to support our 26 years-old "Astronomical Fridays” which are addressed to wide range of public, from schoolchildren to scientists. We also show how important was to rediscover our ancient astronomical cultural past of Incas in order to promote the construction of a Astronomical Center located near Cusco city over 4000 meters above sea level, which includes a tourist-educational observatory, a scientific optical observatory and a solar radio observatory.

  8. Case Study: del Amo Bioventing

    EPA Science Inventory

    The attached presentation discusses the fundamentals of bioventing in the vadose zone. The basics of bioventing are presented. The experience to date with the del Amo Superfund Site is presented as a case study.

  9. Keeping Fit with Asta O'Donnell. An Exercise Program for Problem Backs.

    ERIC Educational Resources Information Center

    O'Donnell, Asta

    An estimated 75 million people in the United States suffer from some type of back problem. Most are caused by muscle strain and improper posture. This book describes an exercise program designed to relieve muscle strain, improve and correct posture, and reduce stress and tension. The book is divided into four sections: "Warm Ups,""Basic Exercise…

  10. Heterogeneous Earth Structure, Deformation, and Slip During the 2010 Mw 7.2 El Mayor-Cucapah Earthquake from Geodetic Data

    NASA Astrophysics Data System (ADS)

    Huang, M. H.; Dickinson, H.; Fielding, E. J.; Sun, J.; Freed, A. M.; Burgmann, R.

    2015-12-01

    The 4th of April 2010 Mw 7.2 El Mayor-Cucapah (EMC) earthquake in Baja California and Sonora, Mexico has primarily right-lateral strike-slip motion and a minor normal slip component. The surface rupture extends about 120 km west of the boundary between the Pacific and the North American plates. The EMC event initiated near the center and ruptured bilaterally into an east-dipping strike-slip fault zone to the north and a west-dipping strike-slip zone to the south. Here we use geodetic measurements including GPS, InSAR (SAR interferometry), and sub-pixel offset measurements to characterize the fault slip during the EMC event. We use dislocation inversion methods to determine fault geometry as well as sub-fault slip distribution based on geodetic measurements. We find that assuming layered earth elastic structure increased the inferred deep slip (10-15 km depth) by up to 1.6 m (60%) compared to assuming a homogeneous elastic structure. Inferred slip was also strongly (up to 2 m) influenced by the choice of observational constraints used in the inversion. The choice of constraints also influenced the inverted seismic moment from Mw 7.20 to 7.26, and the difference is equivalent to a Mw 6.5 event. Our results show that the outcomes of coseismic inversions can vary greatly depending on the methodology, something that needs to be considered both for characterizing an earthquake and when using such results in subsequent studies of postseismic deformation.

  11. El Mayor-Cucapah (Mw 7.2) earthquake: Early near-field postseismic deformation from InSAR and GPS observations

    NASA Astrophysics Data System (ADS)

    Gonzalez-Ortega, J. A.

    2015-12-01

    El Mayor-Cucapah earthquake occurred on 4 April 2010 in northeastern Baja California just south of the U.S.-Mexico border. The earthquake ruptured several previously mapped faults, as well as some unidentified ones, including the Pescadores, Borrego, Paso Inferior and Paso Superior faults in the Sierra Cucapah, and the Indiviso fault in the Mexicali Valley and Colorado River Delta.We conducted several Global Positioning System (GPS) campaign surveys of preexisting and newly established benchmarks within 30 km of the earthquake rupture. Most of the benchmarks were occupied within days after the earthquake, allowing us to capture the very early postseismic transient motions. The GPS data show postseismic displacements in the same direction as the coseismic displacements; time series indicate a gradual decay in postseismic velocities with characteristic time scales of 66 ± 9 days and 20 ± 3 days, assuming exponential and logarithmic decay, respectively. We also analyzed interferometric synthetic aperture radar (InSAR) data from the Envisat and ALOS satellites. The main deformation features seen in the line-of-sight displacement maps indicate subsidence concentrated in the southern and northern parts of the main rupture, in particular at the Indiviso fault, at the Laguna Salada basin, and at the Paso Superior fault. We show that the near-field GPS and InSAR observations over a time period of 5 months after the earthquake can be explained by a combination of afterslip, fault zone contraction, and a possible minor contribution of poroelastic rebound. Far-field data require an additional mechanism, most likely viscoelastic relaxation in the ductile substrate.

  12. Inferred Rheology and Petrology of Southern California and Northwest Mexico Mantle from Postseismic Deformation following the 2010 El Mayor-Cucapah Earthquake

    NASA Astrophysics Data System (ADS)

    Freed, A. M.; Dickinson, H.; Huang, M. H.; Fielding, E. J.; Burgmann, R.; Andronicos, C.

    2015-12-01

    The Mw 7.2 El Mayor-Cucapah (EMC) earthquake ruptured a ~120 km long series of faults striking northwest from the Gulf of California to the Sierra Cucapah. Five years after the EMC event, a dense network of GPS stations in southern California and a sparse array of sites installed after the earthquake in northern Mexico measure ongoing surface deformation as coseismic stresses relax. We use 3D finite element models of seismically inferred crustal and mantle structure with earthquake slip constrained by GPS, InSAR range change and SAR and SPOT image sub-pixel offset measurements to infer the rheologic structure of the region. Model complexity, including 3D Moho structure and distinct geologic regions such as the Peninsular Ranges and Salton Trough, enable us to explore vertical and lateral heterogeneities of crustal and mantle rheology. We find that postseismic displacements can be explained by relaxation of a laterally varying, stratified rheologic structure controlled by temperature and crustal thickness. In the Salton Trough region, particularly large postseismic displacements require a relatively weak mantle column that weakens with depth, consistent with a strong but thin (22 km thick) crust and high regional temperatures. In contrast, beneath the neighboring Peninsular Ranges a strong, thick (up to 35 km) crust and cooler temperatures lead to a rheologically stronger mantle column. Thus, we find that the inferred rheologic structure corresponds with observed seismic structure and thermal variations. Significant afterslip is not required to explain postseismic displacements, but cannot be ruled out. Combined with isochemical phase diagrams, our results enable us to go beyond rheologic structure and infer some basic properties about the regional mantle, including composition, water content, and the degree of partial melting.

  13. [Pertussis in Mexico, an epidemiological overview. A study of 19 years at the Instituto Mexicano del Seguro Social].

    PubMed

    Pérez-Pérez, Gabriela Fidela; Rojas-Mendoza, Teresita; Cabrera-Gaytán, David Alejandro; Grajales-Muñiz, Concepción

    2015-01-01

    Introducción: La infección por Bordetella pertussis ha sido un problema de salud pública en varios países desarrollados y en vías de desarrollo. El objetivo de este estudio fue describir el panorama epidemiológico de los casos de síndrome coqueluchoide y tos ferina del subsistema especial de vigilancia epidemiológica de 1992 a 2011en una población con seguridad social. Métodos: Se obtuvieron los casos del subsistema especial de vigilancia epidemiológica de tos ferina de 1992 a 2011. Se hizo análisis univariado de tasas, razones y proporciones. Se determinó prueba de Wilson para proporciones a un valor alfa del 0.05, t de Student para diferencia de medias. Resultados: Se aprecian ciclos epidémicos, cada tres a cinco años, la incidencia basal promedio, sin contar los años epidémicos, se considera de 0.1 casos confirmados por cada 100 000 derechohabientes adscritos a medicina familiar, la mayor incidencia se registró en 1997 y 2009. Los más afectados han sido los menores de 1 año de edad y en brotes, la enfermedad se presentó en edades mayores. Conclusión: Durante el periodo se observan ciclos epidémicos intermedios de 5 y 3 años, la presentación de la edad es consistente en otros países.

  14. El libro del Relogio del Palacio de las Horas

    NASA Astrophysics Data System (ADS)

    Morales, J. D.

    2009-08-01

    This paper resume the investigation entitled ``El libro del Relogio del Palacio de las Horas''. That consist in an edition of the original text of the book of the Clock of the Palace of the Hours from the Books of the knowledge of Astronomy of Alfonso X (Manuscript 156, Complutense University). And a description of the astronomical functionality of the Clock of the Palace of the Hours. It includes a geometric description of the positional astronomy on which the operation of the Palace is based.

  15. [Registry of myocardial infarction in a tertiary hospital of the Instituto Mexicano del Seguro Social].

    PubMed

    González-Pliego, José Angel; Gudiño-Amezcua, Diego Armando; Celis, Alfredo; Gutiérrez-Díaz, Gonzalo Israel

    2014-01-01

    Introducción: dado que el pronóstico de infarto del miocardio con elevación del segmento ST (IMCEST) depende de su manejo inmediato y de las medidas de prevención secundaria, el no seguir las recomendaciones actuales impide mejorar las expectativas de la población afectada por este padecimiento. El objetivo es describir el perfil clínico-epidemiológico y el proceso de atención del IMCEST en un hospital de tercer nivel. Métodos: se analiza la información clínica, la estratificación de riesgo, la terapia de revascularización y los hábitos de prescripción al egreso de los casos con IMCEST atendidos en un año. Resultados: se incluyeron 246 pacientes con edad promedio de 61 años; el 76 % fueron varones. La mayoría (37.3 %) de IMCEST ocurrió entre los 60 y los 69 años. El sedentarismo fue el factor de riesgo predominante. El 81.7 % de los casos tuvo score TIMI de riesgo bajo. El 35 % tuvo isquemia/viabilidad y en todos los cateterizados se demostraron obstrucciones coronarias. El 76 % se revascularizó con stent, principalmente farmacológico (77.5 %). Al egreso más del 90 % de los casos recibió estatina y antiplaquetarios, mientras otras drogas se prescribieron al 64-82 % de los casos. Conclusiones: el IMCEST predomina en hombres sedentarios de la séptima década. Estratificar el riesgo, buscar isquemia/viabilidad residual y revascularizar con stent farmacológico son prácticas comunes; el cumplimiento de recomendaciones basadas en la evidencia es mejor que en el pasado, pero todavía no es óptimo.

  16. Vacunas contra los virus del papiloma humano

    Cancer.gov

    Una hoja informativa acerca de las vacunas contra los virus del papiloma humano (VPH) para prevenir infecciones con ciertos tipos de VPH, los cuales son la causa principal del cáncer de cuello del útero o cérvix.

  17. A National Action Plan on School Violence and Kids from 2:00 to 8:00 PM. Proposals Adopted at the National Summit by Mayors, Police Chiefs, Educators, Students, Arts, Parks and Recreation Officials, Health Experts, and Representatives from the News Media and Entertainment Industry (Salt Lake City, Utah, September 24, 1998).

    ERIC Educational Resources Information Center

    United States Conference of Mayors, Washington, DC.

    In an emergency response to the recent spree of school shootings, a group of experts came together to draft a national action plan on school violence and children. Participants included: almost 60 members of the U.S. Conference of Mayors Leadership; several mayors from communities which had recently experienced school shootings; police chiefs;…

  18. La utilizacion de los mapas conceptuales en la ensenanza de biologia y su efecto sobre el dominio del proceso de fotosintesis en los estudiantes universitarios

    NASA Astrophysics Data System (ADS)

    Gonzalez Rivera, Maria M.

    prueba Mann-Whitney comparando la posprueba de ambos grupos. El valor de W fue de a 777, para un valor p de 0.2782. Aunque las puntuaciones de las pospruebas del grupo colaborativo fueron mayores que las puntuaciones de la posprueba del grupo individual, la diferencia no fue estadisticamente significativa.

  19. Prevalencia y tamizaje del Trastorno por Déficit de Atención con Hiperactividad en Costa Rica

    PubMed Central

    Weiss, Nicholas T.; Schuler, Jovita; Monge, Silvia; McGough, James J.; Chavira, Denise; Bagnarello, Monica; Herrera, Luis Diego; Mathews, Carol A.

    2015-01-01

    Resumen La investigación tuvo como propósito estimar la prevalencia del Trastorno por Déficit de Atención con Hiperactividad (TDAH) en Costa Rica y determinar si la versión en español del cuestionario Swanson Nolan and Pelham Scale IV (SNAP-IV) es un instrumento de tamizaje útil en una población de niños y niñas escolares costarricenses. El instrumento fue entregado a padres y maestros de 425 niños entre 5 y 13 años de edad (promedio = 8.8). Todos fueron evaluados con el instrumento Swanson, Kotkin, Agler, M-Flynn and Pelham Scale (SKAMP). Su diagnóstico fue confirmado con una entrevista clínica. La sensibilidad y la especificidad del SNAP-IV fueron evaluadas como predictores de criterios de diagnóstico según el DSM-IV. La prevalencia puntual en la muestra del TDAH fue del 5%. El tamizaje más preciso lo hizo el SNAP-IV completado por el maestro en un corte de 20%, con una sensibilidad de 96% y una especificidad de un 82%. La sensibilidad de los instrumentos completados por los padres fue más baja que aquella de los maestros. El SNAP-IV completado por las maestras con un corte aislando el 20% de los mayores puntajes categorizó correctamente a un 87% de los sujetos. PMID:22432094

  20. [Implementation of respiratory rehabilitation in the municipalities of Valparaíso, Viña del Mar, Quilpué and Villa Alemana in 2013].

    PubMed

    Manriquez Villarroel, Pablo; Colines Rodríguez, Yasna; Poblete Vega, Felipe; Otárola Bravo, Jaime; Paredes Barrera, Cristhian; Acuña Cabrera, Ana María

    2014-10-03

    Introducción: La rehabilitación respiratoria es un pilar fundamental en el tratamiento del paciente con Enfermedad Pulmonar Obstructiva Crónica. Reduce importantemente los costos para el sistema de salud, el uso de recursos sanitarios, disminuyendo la estadía hospitalaria y las consultas a servicios de urgencia. Objetivo: Describir la condición actual de la rehabilitación respiratoria en los centros de atención primaria ubicados en la región de Valparaíso. Método: Se aplicó una encuesta cerrada a cada profesional a cargo del área respiratoria en los centros de atención primaria de salud. La muestra estuvo conformada por 32 centros de salud correspondientes a las comunas de Valparaíso, Viña del Mar, Quilpué y Villa Alemana. Resultados: 9 centros (28%) del total de la muestra realizan rehabilitación respiratoria y el mismo número tiene un programa de rehabilitación estructurado. En 15 (47%) de los centros existe un Nutricionista dentro del equipo de salud. En el 100% de los centros se evalúa a los pacientes mediante espirometría y escalas de disnea. La mayoría de los centros (89%) realiza entrenamiento de extremidades superiores e inferiores. Dentro de los factores que limitan la realización de la rehabilitación respiratoria, 20 (63%) centros refieren que el horario de atención es uno de los factores más limitantes, mientras que 23 (72%) centros refieren que no cuentan con espacio físico adecuado y 22 (69%) centros relatan no contar con los implementos mínimos necesarios. Discusión: Los datos obtenidos indican que en la mayoría de los centros encuestados no se realiza rehabilitación respiratoria como parte del tratamiento del paciente con Enfermedad Pulmonar Obstructiva Crónica, principalmente por problemas de recursos humanos, materiales e infraestructura.

  1. RASTREO DEL CANCER COLORRECTAL CONOCIMIENTO Y ACTITUD DE LA POBLACION

    PubMed Central

    CASAL, ENRIQUE R.; VELAZQUEZ, ELIZABETH N.; MEJIA, RAUL M.; CUNEO, ALDO; PEREZ-STABLE, ELISEO J.

    2014-01-01

    Resumen El rastreo de cáncer colorrectal (CCR) cuenta con fuertes evidencias en su favor. Datos preliminares indican que a pesar de ello no se lleva a cabo con la frecuencia adecuada. Se intenta aquí determinar, dentro de un Sistema de Salud que cuenta con los recursos necesarios, los elementos que facilitan o generan barreras para concretar esta práctica preventiva, cuántos individuos lo ponen en práctica y qué predice esta conducta. Se realizó una encuesta telefónica a los afiliados de una Obra Social de empleados de la Universidad de Buenos Aires, de los que 132 completaron el cuestionario (tasa de respuesta 70%). Los elementos considerados facilitadores del rastreo obtuvieron respuestas afirmativas en el 64 a 97%, mientras que los que definían barreras un 11 a 27%. En este último grupo, una categoría diferenciada la constituía el miedo a los efectos adversos: 39%, y el sentimiento de vergüenza relacionado con los procedimientos: 30%. Un 33% de los encuestados tenían hecho un método de rastreo, mayoritariamente de sangre oculta (27), sigmoideoscopía (11) y colonoscopía (20). Una mayoría afirmó que “se haría el procedimiento si el médico se lo recomendara” (95%), o “no se lo haría excepto que su médico se lo aconseje” (87%). Contestar afirmativamente que “los médicos hacen lo mejor para los pacientes” se asoció con haberse hecho un método de rastreo de CCR, OR 1.55 (IC 95%: 1.02-2.37) p: 0.04. El grupo de individuos estudiado parece bien predispuesto para el rastreo del CCR, la recomendación médica sería aquí un determinante prominente para ponerlo en práctica. PMID:19414294

  2. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Marina Del Rey, CA. 80.1118... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del...

  3. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marina Del Rey, CA. 80.1118... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del...

  4. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Marina Del Rey, CA. 80.1118... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del...

  5. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Marina Del Rey, CA. 80.1118... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del...

  6. Analysis of Triggering of Earthquakes and Tremor in the Western U.S. due to the 2010 El Mayor Cucapah Earthquake and the Mw6.8 Mendocino Triple Junction Earthquake in 2014

    NASA Astrophysics Data System (ADS)

    Hatch, R. L.; Polet, J.

    2014-12-01

    Recent studies indicate that the passage of seismic waves from large earthquakes are able to trigger small earthquakes and tremor at regional distances. These small events may be detected by applying a high-pass filter to seismograms to remove the much larger ground motion amplitudes from the large distant earthquake. Our interests are in examining the local triggering of earthquakes and tremor throughout the West Coast of North America from the magnitude 7.2 El Mayor-Cucapah 2010 earthquake and the magnitude 6.8 Northern California, March 10, 2014 earthquake, just north of the Mendocino Triple Junction. We will present the results of the analysis of waveform data from hundreds of seismometers throughout Southern California, Northern California, Oregon, Washington, as well as some stations bordering these states. Our preliminary results suggest that triggering of local earthquakes and tremor occurred for both earthquakes. In the case of the records of the Southern California stations for the El Mayor Cucapah 2010 earthquake, 27 stations showed triggering near the seismic station. 13 of these stations are located in or near known geothermal areas, while others were located along active faults and one offshore. While conducting this study, we detected an instrumental noise signal present in 63 of the Southern California seismograms for the El Mayor-Cucapah earthquake. Initially, the signal looked like a typical triggered event, yet with further investigation we found its likely cause to be instrumental noise. We plan to relate our observations of triggered seismicity and tremor to the tectonic environment to test the hypothesis that triggering and tremor most commonly occurs in volcanic and geothermal areas.

  7. Tierra del Fuego, Argentina, South America

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Mitre Peninsula is the easternmost tip of Tierra del Fuego, Argentina, (54.5S, 65.5W). Early winter snow can be seen on this south tip of the Andes Mountains. These same mountains continue underwater to Antarctica. The Strait of Magellan, separating the South American mainland from Tierra del Fuego is off the scene to the north and west, but the Strait of LeMaire, separating Tierra del Fuego from the Isla de los Estados can be seen.

  8. Control del cáncer y salud mundial: noticia del Instituto Nacional del Cáncer (NCI)

    Cancer.gov

    En combinación con una reunión de alto nivel de las Naciones Unidas sobre enfermedades no transmisibles en países en vías de desarrollo, el doctor Harold Varmus, director del NCI, y el doctor Ted L. Trimble, del NCI, han publicado un comentario en Science

  9. Líneas Vitales: Programas y servicios del NCI

    Cancer.gov

    Artículos y videos sobre los programas y servicios del Instituto Nacional del Cáncer de la serie educativa Líneas Vitales del NCI, la cual está dirigida especialmente a poblaciones multiculturales.

  10. DISYUNTIVAS EN LAS CONCEPCIONES SOBRE AUTONOMÍA Y BENEFICENCIA QUE AFECTAN LA TERAPÉUTICA DEL INTENTO SUICIDA.

    PubMed

    Mondragón, Liliana; Monroy, Zuraya; Ito, Ma Emily; Medina-Mora, Dra Ma Elena

    2010-06-01

    El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio.La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos.Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos.

  11. DISYUNTIVAS EN LAS CONCEPCIONES SOBRE AUTONOMÍA Y BENEFICENCIA QUE AFECTAN LA TERAPÉUTICA DEL INTENTO SUICIDA.

    PubMed

    Mondragón, Liliana; Monroy, Zuraya; Ito, Ma Emily; Medina-Mora, Dra Ma Elena

    2010-06-01

    El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio.La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos.Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos. PMID:20830214

  12. DISYUNTIVAS EN LAS CONCEPCIONES SOBRE AUTONOMÍA Y BENEFICENCIA QUE AFECTAN LA TERAPÉUTICA DEL INTENTO SUICIDA1

    PubMed Central

    Mondragón, Liliana; Monroy, Zuraya; Ito, Ma. Emily; Medina-Mora, Dra. Ma. Elena

    2010-01-01

    El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio. La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos. Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos. PMID:20830214

  13. Instantánea del linfoma

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el linfoma; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  14. Instantánea del melanoma

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el melanoma; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  15. Instantánea del sarcoma

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el sarcoma; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  16. Instantánea del mieloma

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el mieloma; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  17. Posible origen del agua terrestre

    NASA Astrophysics Data System (ADS)

    di Sisto, R. P.; Orellana, R. B.; Brunini, A.

    The most plausible sources of the terrestrial water are found in the main external asteroid belt, the giant planetary region and in the Kuiper belt, because of its great presence of ices. However, the timing of earth planets's formation (108 years) marks an inferior limit for the dynamical lifetime of the objects of interest since the previous megaimpacts would volatilize the icy material previusly accreted. The central parameter that allow us to rebuild the origin of water in the solar system is the rate of the Deuterium/Hydrogen isotope (D/H). The D/H measured in three comets has an average value two times greater that the value measured in the terrestrial oceans. Morbidelli et al. support that the main part of the present buldge of water on earth was product of the accretion, in the last formation stages, of some planetary embryos originally formed in the external asteroid belt. In the Jupiter zone, the D/H could be of the order of the terrestrial value. Then, we would have there posible sources with an apropiate isotopic composition that have survived for several 108 years. These sources are: the Troyan asteroids, objects in the Jupiter-Saturn region and objects in the external limit of the asteroidal belt. As for this last group we have considered in this work, the Hilda Family asteroids. The Hilda Family asteroids are placed in the 3/2 mean motion resonance with Jupiter. From the present distribution of the Hilda's orbital parameters, we generate randomly, inicial conditions for 500 massless particles in the Hildas region. Trough numerical simulations we follow their dynamical evolution during 500 millon years and its final state. The mayority of these particles are eyected out of the Solar System (76 %) due to the gravitational action of Jupiter and only a 24 % stay in the resonance zone. The 8.1 % of the particles that leave the resonance, hit Jupiter. Some objects have encounters with the terrestrial planets. From the number of encounters with each planet

  18. Surface rupture and slip variation induced by the 2010 El Mayor-Cucapah earthquake, Baja California, quantified using COSI-Corr analysis on pre- and post-earthquake LiDAR acquisitions

    NASA Astrophysics Data System (ADS)

    Leprince, S.; Hudnut, K. W.; Akciz, S. O.; Hinojosa-Corona, A.; Fletcher, J. M.

    2011-12-01

    One-hundred and three years after the publication of the Lawson report on the Great 1906 earthquake, accurate documentation of surface deformation along the entire length of an earthquake is still challenging. Analysis of pre- and post-earthquake topographic data provides an opportunity to deliver the full 3D displacement field of the ground's surface. However, direct differencing of a pre- and post-earthquake digital topography model (DEM) generally leads to biased estimation of the vertical component of the deformation. Indeed, if the earthquake also produced significant horizontal motion, or if the pre- and post-earthquake DEM acquisitions exhibit non-negligible horizontal mis-registration, then the vertical offset measured by direct differencing will be biased by the local topography gradient. To overcome this limitation, we use the COSI-Corr sub-pixel correlation algorithm to estimate the relative horizontal offset between the pre- and post- 2010 El Mayor - Cucapah earthquake high resolution LiDAR acquisitions. Compensating for the horizontal offset between the two LiDAR acquisitions allows us to estimate unbiased measurements of the vertical component of the surface fault rupture induced by the El Mayor-Cucapah earthquake. We will also show the limitations of the available data set, such as aircraft jitter artifacts, which impaired accurate measurements of the horizontal component of the surface deformation. This analysis shows an unprecedented view of the complete vertical slip component of the rupture induced by the Mw 7.2 2010 El Mayor-Cucapah earthquake, sampled at every 5 m, over a length of about 100 km, and with a vertical accuracy of a few centimeters. Using sampling bins as narrow as 150 m and 1.5 km long, variations in the vertical component of an oblique slip earthquake are presented, with breaks along multiple fault-strands showing opposite dip directions and diffuse boundaries. With the availability of high precision pre- and post-earthquake data

  19. Incentivos para atraer y retener personal de salud de zonas rurales del Perú: un estudio cualitativo

    PubMed Central

    Huicho, Luis; Canseco, Francisco Díez; Lema, Claudia; Miranda, J. Jaime; Lescano, Andrés G.

    2014-01-01

    El objetivo fue identificar incentivos de atracción y retención en zonas rurales y distantes de Ayacucho, Perú. Fueron realizadas entrevistas en profundidad con 80 médicos, enfermeras, obstetras y técnicos (20 por grupo) de las zonas más pobres y con 11 funcionarios. No existen políticas sistemáticas de atracción y retención de personal de salud en Ayacucho. Los principales incentivos, en orden de importancia, fueron mejoras salariales, oportunidades de formación y capacitación, estabilidad laboral y nombramiento, mejoras en infraestructura y equipos, e incremento del personal. Se mencionaron también mejoras en la vivienda y alimentación, mayor cercanía con la familia y reconocimiento por el sistema de salud. Existen coincidencias y singularidades entre los distintos grupos sobre los incentivos clave para estimular el trabajo rural, que deben considerarse al diseñar políticas públicas. Las iniciativas del Estado deben comprender procesos rigurosos de monitoreo y evaluación, para asegurar que las mismas tengan el impacto deseado. PMID:22488318

  20. Autoreporte de exposición a publicidad y promoción de tabaco en una cohorte de fumadores mexicanos: Antes y durante la publicación de la Ley General para el Control del tabaco en 2008

    PubMed Central

    Hernández, Rosaura Pérez; Thrasher, James F.; Bolaños, Rosibel Rodríguez; Gutiérrez, Inti Barrientos; Hernández, Norma A Ibañez

    2015-01-01

    Resumen Objetivo Determinar en población fumadora el nivel de exposición a la mercadotecnia por parte de la Industria Tabacalera (IT), a través de diferentes métodos de promocionar sus productos de tabaco, antes y durante la publicación de la Ley General para el Control del Tabaco (LGCT) en 2008. Material y métodos Estudio de cohorte en fumadores adultos (n=941 pre-LGCT y n=1051 post-LGCT) de cuatro ciudades mexicanas. Se realizaron análisis multivariados mediante modelos de ecuaciones de estimación generalizada (GEE). Resultados Se incremento el autoreporte de recepción de muestras gratis de cigarros (3.7% a 8.1%), ropa o artículos con marcas o logos (3.6% a 6.4%), haber visto información sobre eventos especiales (1.9% a 4.7%), y bares, antros y discos para mayores de edad (21.4% a 28%). Se observaron decrementos de publicidad en exteriores (54.7% a 47.2%). Conclusión Es necesaria una política integral con prohibiciones totales de la publicidad y promoción de los productos de tabaco que integre mayor vigilancia y sanciones para lograr la disminución y prevención del consumo de tabaco. PMID:22689158

  1. Produccion Gaseosa del Cometa Halley: Erupciones Y Fotodisociacion del Radical OH

    NASA Astrophysics Data System (ADS)

    Silva, A. M.; Mirabel, I. F.

    1990-11-01

    RESUMEN:En este trabajo informamos la detecci6n de 20 erupciones en la li'nea de =18cm (1667MHz) del radical OH en el Cometa Halley.Las observaciones incluyen todos los monitoreos existentes y se extienden desde 120 dias antes del perihelio hasta 90 dias despues.Se detectan bruscos crecimientos en el flujo medido,hasta un factor 1O,seguidos por decaimientos lentos asociados con la fotodisociaci6n del OH. Se obtuvieron valores para el tiempo de vida fotoquimico del OH y del H2O basandose en el modelo desarrollado previamente por Silva(1988). Esos tiempos de vida estan de acuerdo con predicciones teoricas y con las observaciones en el Ultravioleta, y los resultados, los que son fuertemente dependientes de la velocidad heliocentrica del Coineta (variando hasta un factor 6), han sido calculados para varios rangos de velocidad entre +28 y -28 km/seg. Key wo'L :

  2. Gonadal dysgenesis in del (18p) syndrome

    SciTech Connect

    Telvi, L.; Ion, A.; Fouquet, F.

    1995-07-17

    We report on a girl with syndromal gonadal dysgenesis and a de novo del (18p). Genetic factors controlling gonadal development are located not only on the X chromosome, but also on autosomes. The present case suggests that one of these genes is situated on 18p. We conclude that patients with del (18p) syndrome should be evaluated for gonadal dysgenesis. 16 refs., 3 figs.

  3. Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"

    ERIC Educational Resources Information Center

    LaGreca, Nancy

    2012-01-01

    This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

  4. The Mayors' Charter Schools

    ERIC Educational Resources Information Center

    Magee, Michael

    2014-01-01

    In 2007, the case could be made that Rhode Island had, dollar for dollar, the worst-performing public education system in the United States. Despite per-pupil expenditures ranking in the top 10 nationally, the state's 8th graders fared no better than 40th in reading and 33rd in math on the National Assessment of Educational Progress (NAEP).…

  5. Some characteristics of the complex El Mayor-Cucapah, MW7.2, April 4, 2010, Baja California, Mexico, earthquake, from well-located aftershock data from local and regional networks.

    NASA Astrophysics Data System (ADS)

    Frez, J.; Nava Pichardo, F. A.; Acosta, J.; Munguia, L.; Carlos, J.; García, R.

    2015-12-01

    Aftershocks from the El Mayor-Cucapah (EMC), MW7.2, April 4, 2010, Baja California, Mexico, earthquake, were recorded over two months by a 31 station local array (Reftek RT130 seismographs loaned from IRIS-PASSCAL), complemented by regional data from SCSN, and CICESE. The resulting data base includes 518 aftershocks with ML ≥ 3.0, plus 181 smaller events. Reliable hypocenters were determined using HYPODD and a velocity structure determined from refraction data for a mesa located to the west of the Mexicali-Imperial Valley. Aftershock hypocenters show that the El Mayor-Cucapah earthquake was a multiple event comprising two or three different ruptures of which the last one constituted the main event. The main event rupture, which extends in a roughly N45°W direction, is complex with well-defined segments having different characteristics. The main event central segment, located close to the first event epicenter is roughly vertical, the northwest segment dips ~68°NE, while the two southeast segments dip ~60°SW and ~52°SW, respectively, which agrees with results of previous studies based on teleseismic long periods and on GPS-INSAR. All main rupture aftershock hypocenters have depths above 10-11km and, except for the central segment, they delineate the edges of zones with largest coseismic displacement. The two southern segments show seismicity concentrated below 5km and 3.5km, respectively; the paucity of shallow seismicity may be caused by the thick layer of non-consolidated sediments in this region. The ruptures delineated by aftershocks in the southern regions correspond to the Indiviso fault, unidentified until the occurrence of the EMC earthquake. The first event was relocated together with the aftershocks; the epicenter lies slightly westwards of published locations, but it definitely does not lie on, or close to, the main rupture. The focal mechanism of the first event, based on first arrival polarities, is predominantly strike-slip; the focal plane

  6. Visiting the Gödel universe.

    PubMed

    Grave, Frank; Buser, Michael

    2008-01-01

    Visualization of general relativity illustrates aspects of Einstein's insights into the curved nature of space and time to the expert as well as the layperson. One of the most interesting models which came up with Einstein's theory was developed by Kurt Gödel in 1949. The Gödel universe is a valid solution of Einstein's field equations, making it a possible physical description of our universe. It offers remarkable features like the existence of an optical horizon beyond which time travel is possible. Although we know that our universe is not a Gödel universe, it is interesting to visualize physical aspects of a world model resulting from a theory which is highly confirmed in scientific history. Standard techniques to adopt an egocentric point of view in a relativistic world model have shortcomings with respect to the time needed to render an image as well as difficulties in applying a direct illumination model. In this paper we want to face both issues to reduce the gap between common visualization standards and relativistic visualization. We will introduce two techniques to speed up recalculation of images by means of preprocessing and lookup tables and to increase image quality through a special optimization applicable to the Gödel universe. The first technique allows the physicist to understand the different effects of general relativity faster and better by generating images from existing datasets interactively. By using the intrinsic symmetries of Gödel's spacetime which are expressed by the Killing vector field, we are able to reduce the necessary calculations to simple cases using the second technique. This even makes it feasible to account for a direct illumination model during the rendering process. Although the presented methods are applied to Gödel's universe, they can also be extended to other manifolds, for example light propagation in moving dielectric media. Therefore, other areas of research can benefit from these generic improvements. PMID

  7. Calidad de Imagen del Telescopio UNAM212

    NASA Astrophysics Data System (ADS)

    Cobos, F. J.; Teiada de Vargas, C.

    1987-05-01

    El telescopio UNAM2l2, del Observatorio Astronómico Nacional, situado en la Sierra de San Pedro Mártir (Baja California, México), cumplira en un futuro muy cercano siete años de uso para fines de investigación astronómica. Aunque en este tiempo no se ha efectuado un estudio sistemático acerca de su comportamiento óptico y de los factores que influyen en la calidad de las imágenes, se han realizado pruebas diversas, estudios parciales y reuniones especificas, cuyos resultados no siempre se han difundido ampliamente y generalmente no se han presentado por escrito. Es por ello que hemos creido necesario intentar una recopilación de la información existente para poder con ella establecer un diagnóstjco que, aunque no sea definitivo, sirva de base para futuros trabajos tendientes a optimizar el comportamiento óptico del telescopio. Es evidente que un buen número de las conclusiones que se presentan son resultado del trabajo de muchas personas ó de esfuerzos colectivos. Asimismo, hemos tratado de localizar información bibliográfica que pueda ser de utilidad. Nuestro objetivo primordial ha consistido en centrarnos en la óptica del telescopio y su calidad, pero también se han considerado otros aspectos que puedan afectar las imágenes obtenidas tales como: celda del primario, `seeing' local y externo, flexiones posibles en la estructura mecánica del telescopio, etc.

  8. Visiting the Gödel universe.

    PubMed

    Grave, Frank; Buser, Michael

    2008-01-01

    Visualization of general relativity illustrates aspects of Einstein's insights into the curved nature of space and time to the expert as well as the layperson. One of the most interesting models which came up with Einstein's theory was developed by Kurt Gödel in 1949. The Gödel universe is a valid solution of Einstein's field equations, making it a possible physical description of our universe. It offers remarkable features like the existence of an optical horizon beyond which time travel is possible. Although we know that our universe is not a Gödel universe, it is interesting to visualize physical aspects of a world model resulting from a theory which is highly confirmed in scientific history. Standard techniques to adopt an egocentric point of view in a relativistic world model have shortcomings with respect to the time needed to render an image as well as difficulties in applying a direct illumination model. In this paper we want to face both issues to reduce the gap between common visualization standards and relativistic visualization. We will introduce two techniques to speed up recalculation of images by means of preprocessing and lookup tables and to increase image quality through a special optimization applicable to the Gödel universe. The first technique allows the physicist to understand the different effects of general relativity faster and better by generating images from existing datasets interactively. By using the intrinsic symmetries of Gödel's spacetime which are expressed by the Killing vector field, we are able to reduce the necessary calculations to simple cases using the second technique. This even makes it feasible to account for a direct illumination model during the rendering process. Although the presented methods are applied to Gödel's universe, they can also be extended to other manifolds, for example light propagation in moving dielectric media. Therefore, other areas of research can benefit from these generic improvements.

  9. Radio-Observaciones del OH EN la Coma del Cometa Halley Desde EL Hemisferio Sur

    NASA Astrophysics Data System (ADS)

    Silva, A. M.; Bajaja, E.; Morras, R.; Cersosimo, J. C.; Martin, M. C.; Arnal, E. M.; Poppel, W. G. L.; Colomb, F. R.; Mazzaro, J.; Olalde, J. C.; Boriakoff, V.; Mirabel, I. F.

    1987-05-01

    Se utilizó una antena de 30 metros del Instituto Argentino de Radioastronomía para observaciones diarias Cf ebrero a abril de 1986) de la transición en 1667 MHz ( λ = 18 cm) del OH en la coma del cometa Halley. De las observaciones realizadas se concluye: 1) El número promedio de moléculas de OH en la coma durante 37 días de observación fue de (8.9±3.5)x1034 moléculas, lo que implica una tasa de producción promedio de OH de 1.8x1029 moléculas seg-1 y consecuentemente una pérdida de masa promedio de 17±6 toneladas seg-1 . Este valor está de acuerdo con las mediciones realizadas por las sondas Vega y Giotto. 2) El monitoreo desde el lAR revela la existencia de variaciones bruscas en los flujos de absorción del OH. Estas variaciones son consistentes con los modelos que representan la producción gaseosa a partir de ejecciones y/o desprendimientos discretos de materia congelada del núcleo. 3) Las variaciones en la densidad de flujo son consistentes con las estimaciones de los tiem- pos de vida medios del H2O y del OH en presencia del campo de radiación solar. 4) Se encuentra una correlación entre la intensidad del flujo absorbido y anisotropías en Ia dinamica de la coma.

  10. [Revista de Gastroenterologia del Peru: 25 years].

    PubMed

    Celestino Fernández, Alvaro

    2005-01-01

    In this article is described in a very summarized form the history of the Revista de Gastroenterología del Perú (RGP) that dates from the same origins of the Sociedad de Gastroenterología del Perú, when based in October 30 of 1952 already glimpse the presence of the RGP as the official organ for the publication for studies of doctors of the society or foreign guests. We spent 29 years, and this idea becomes reality; and today the RGP turns to their XXV anniversary. The RGP, to locate itself as the Peruvian medical publication best reputation.

  11. Manual del McVCO 1999

    USGS Publications Warehouse

    McChesney, P.J.

    1999-01-01

    El McVCO es un generador de frecuencias basado en un microcontrolador que reemplaza al oscilador controlado por voltaje (VCO) utilizado en telemetría analógica de datos sísmicas. Acepta señales de baja potencia desde un sismómetro y produce una señal subportadora modulada en frecuencia adecuada para enlaces telefónicos o vía radio a un lugar remoto de recolección de datos. La frecuencia de la subportadora y la ganancia pueden ser seleccionadas mediante un interruptor. Tiene la opción de poder operar con dos canales para la observación con ganancia alta y baja. El McVCO fue diseñado con el propósito de mejorar la telemetría analógica de las señales dentro de la Pacific Northwest Seismograph Network (PNSN) (Red Sismográfica del Noroeste del Pacífico). Su desarrollo recibió el respaldo del Programa de Geofísica de la Universidad de Washington y del "Volcano Hazards and Earthquake Hazards programs of the United States Geological Survey (USGS) (Programa de Investigaciones de Riesgos Volcánicos y Programa de Investigaciones de Riesgos Sísmicos de los EEUU). Cientos de instrumentos se han construido e instalado. Además de utilizarlo el PNSN, el McVCO es usado por el Observatorio Vulcanológico de Alaska para monitorear los volcanes aleutianos y por el USGS Volcano Disaster Assistance Program (Programa de Ayuda en las Catástrofes Volcánicas del USGS) para responder a crisis volcánicas en otros países. Este manual cubre el funcionamiento del McVCO, es una referencia técnica para aquellos que necesitan saber con más detalle cómo funciona el McVCO, y cubre una serie de temas que requieren un trato explícito o que derivan del despliegue del instrumento.

  12. WWC Review of the Report "Meeting the Challenge of Combating Chronic Absenteeism: Impact of the NYC Mayor's Interagency Task Force on Chronic Absenteeism and School Attendance and Its Implications for Other Cities." What Works Clearinghouse Single Study Review

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2014

    2014-01-01

    The 2013 study, "Meeting the Challenge of Combating Chronic Absenteeism: Impact of the NYC Mayor's Interagency Task Force on Chronic Absenteeism and School Attendance and Its Implications for Other Cities", examined the impact of the strategies developed by an interagency task force in New York City to combat chronic absenteeism in…

  13. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Marina Del Rey, CA. 80.1118 Section 80.1118 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light...

  14. Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)

    USGS Publications Warehouse

    Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; Rivera, M.C.; Munoz, A.

    1998-01-01

    La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

  15. Hopeful (protein InDel) monsters?

    PubMed

    Tóth-Petróczy, Agnes; Tawfik, Dan S

    2014-06-10

    In this issue of Structure, Arpino and colleagues describe in atomic detail how a protein stomachs a deletion within a helix, an event that rarely occurs in nature or in the lab. Can insertions and deletions (InDels) trigger dramatic structural transitions?

  16. Near Infrared Photometry of Nova Del 2013

    NASA Astrophysics Data System (ADS)

    Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.

    2013-09-01

    We continued to follow Nova Del 2013 during the period from 31.15 August 2013 UT through 25.18 September 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). Vega (alpha Lyrae) is used as the standard star.

  17. del and Gödel-type universes in Brans-Dicke theory

    NASA Astrophysics Data System (ADS)

    Agudelo, J. A.; Nascimento, J. R.; Petrov, A. Yu.; Porfírio, P. J.; Santos, A. F.

    2016-11-01

    In this paper, conditions for existence of Gödel and Gödel-type solutions in Brans-Dicke (BD) scalar-tensor theory and their main features are studied. The consistency of equations of motion, causality violation and existence of CTCs (closed time-like curves) are investigated. The role which cosmological constant and Mach principle play to achieve the consistency of this model is studied.

  18. Observación y registro fotográfico del cometa HYAKUTAKE C/1996 B2

    NASA Astrophysics Data System (ADS)

    Arquiola, A. P.; Arquiola, F. E.

    Desde el momento en que nos llega la información del descubrimiento, comenzamos la observación de forma detallada a fin de apreciar y seguir su creciente actividad. La primera observación se realizó el 17 de febrero de 1996 a las 4h20m UT con nuestro telescopio de 300mm newtoniano de f/6.5, con una muy buena transparencia atmosférica, estimando una magnitud de 8.5. Realizábamos observaciones casi todas las noches, mientras nos lo permitían las condiciones climáticas. Ya el 26 de febrero el cometa presentaba un aspecto muy particular, ligeramente distinto a las primeras observaciones, ya que comenzamos a notar su gran actividad. En primer lugar se destacaba la cola de iones mucho mas extensa que la cola de polvo. Magnitud estimada 7.5. El 19 de marzo ya era visible a simple vista y en especial su cola muy abierta y extensa (3 grados) y no quedaba duda alguna que la última noche de observación del cometa en el horizonte de la Ciudad de Funes, que fue el 24 de marzo de 1996, un día antes del acercamiento a la Tierra, tendríamos una apreciación del cometa en su máximo esplendor. El 24 de marzo de 1996 a las 4hs UT, asomó el cometa por el horizonte NE, con su cola espectacular, llegando a medir 23 grados de longitud, muy recta y brillante, y su cabellera muy estelar. A este marco de observación se sumaron mas de 600 personas que participaron usando instrumentos, siendo la mayoría de los concurrentes de la vecina Ciudad de Rosario, ya que su observación era a muy baja atura sobre el horizonte norte. Instrumentos utilizados : Telescopio Newtoniano 300mm f/6.5, Telescopio Schmidt-Cassegrain 200mm , Binoculares 10 x 50, 7 x 50, Lente normal 50mm a f/1.8, Película 100 - 400 ASA Lugar de Observación : Ciudad de Funes, zona rural, ``Estancia La Polola" Latitud: - 32o 55' Longitud: 60o 40' Oeste

  19. Testing long-period ground-motion simulations of scenario earthquakes using the Mw 7.2 El Mayor-Cucapah mainshock: Evaluation of finite-fault rupture characterization and 3D seismic velocity models

    USGS Publications Warehouse

    Graves, Robert W.; Aagaard, Brad T.

    2011-01-01

    Using a suite of five hypothetical finite-fault rupture models, we test the ability of long-period (T>2.0 s) ground-motion simulations of scenario earthquakes to produce waveforms throughout southern California consistent with those recorded during the 4 April 2010 Mw 7.2 El Mayor-Cucapah earthquake. The hypothetical ruptures are generated using the methodology proposed by Graves and Pitarka (2010) and require, as inputs, only a general description of the fault location and geometry, event magnitude, and hypocenter, as would be done for a scenario event. For each rupture model, two Southern California Earthquake Center three-dimensional community seismic velocity models (CVM-4m and CVM-H62) are used, resulting in a total of 10 ground-motion simulations, which we compare with recorded ground motions. While the details of the motions vary across the simulations, the median levels match the observed peak ground velocities reasonably well, with the standard deviation of the residuals generally within 50% of the median. Simulations with the CVM-4m model yield somewhat lower variance than those with the CVM-H62 model. Both models tend to overpredict motions in the San Diego region and underpredict motions in the Mojave desert. Within the greater Los Angeles basin, the CVM-4m model generally matches the level of observed motions, whereas the CVM-H62 model tends to overpredict the motions, particularly in the southern portion of the basin. The variance in the peak velocity residuals is lowest for a rupture that has significant shallow slip (<5 km depth), whereas the variance in the residuals is greatest for ruptures with large asperities below 10 km depth. Overall, these results are encouraging and provide confidence in the predictive capabilities of the simulation methodology, while also suggesting some regions in which the seismic velocity models may need improvement.

  20. Abundancias químicas de las estrellas CP del grupo HgMn μ Leporis y 53 Tauri. II. Boro, Berilio, Carbono, Magnesio, Aluminio y Silicio

    NASA Astrophysics Data System (ADS)

    López García, Z.; Malaroda, S. M.; Faraggiana, R.

    Se determinan las abundancias químicas de los elementos más livianos presentes en dos estrellas CP del grupo HgMn, μ Lep y 53 Tau, utilizando espectros IUE de alta resolución y técnicas de cálculo de espectros sintéticos. Para el cálculo de las líneas se utiliza la lista mas completa de datos atómicos disponible y el programa SYNTHE. Para el cálculo de la abundancia de un elemento se comparan, para cada imagen, los perfiles observados del mayor número de líneas presentes con los perfiles calculados obtenidos por variación de las abundancias iniciales, reteniendo la abundancia para la cual el acuerdo entre las líneas observadas y calculadas es considerado visualmente el mejor. Los resultados obtenidos son comparados con los estimados por la teoría de la difusión.

  1. Educación sobre sexualidad y prevención del VIH: un diagnóstico para América Latina y el Caribe

    PubMed Central

    DeMaria, Lisa M.; Galárraga, Omar; Campero, Lourdes; Walker, Dilys M.

    2016-01-01

    RESUMEN Objetivo Mostrar, a través de un diagnóstico en América Latina y el Caribe, el panorama legislativo y curricular sobre sexualidad y prevención contra el virus de inmunodeficiencia humana (VIH) en el ámbito escolar, contrastándolo con los comportamientos sexuales reportados en encuestas demográficas y de salud. Métodos En mayo de 2008 se realizó, con el apoyo del Fondo de Población de las Naciones Unidas (UNFPA), una encuesta a informantes clave en 34 países de la Región. El cuestionario autoaplicado solicitó información sustantiva de agentes de las diferentes partes interesadas, como ministerios de educación y de salud, sobre los programas de prevención contra el VIH/Sida que se están aplicando en las escuelas. Resultados Respondieron a la encuesta 27 países que representan 95,5% de la población objetivo (6 a 18 años de edad). La mayoría de los países informó tener al menos un libro de texto o un capítulo específico para enseñar los temas de educación sobre sexualidad y prevención del VIH. En la escuela secundaria se cubren la mayor parte de los temas pertinentes relevantes para la educación sobre sexualidad, pero no todos. Por ejemplo, el problema de la discriminación por orientación o preferencia sexual no se incluye en los programas escolares. Conclusiones El material educativo sobre sexualidad debe ser revisado y actualizado periódicamente de modo que refleje los avances en los temas y en la forma de tratar los contenidos. En cada país el currículo debe abordar el tema del respeto a la diversidad sobre orientación, preferencia e identidad sexuales, y en particular el manejo apropiado de la educación para prevenir infecciones de transmisión sexual (ITS) en hombres que tienen sexo con hombres. Los esfuerzos de evaluación de la efectividad de los programas deben contemplar desenlaces tales como marcadores biológicos (incidencia y prevalencia de ITS y embarazo) y no únicamente indicadores de conocimiento y

  2. The Punta del Cobre Formation, Punta del Cobre Candelaria area, northern Chile

    NASA Astrophysics Data System (ADS)

    Marschik, Robert; Fontboté, Lluís.

    2001-09-01

    The Punta del Cobre Formation hosts the iron oxide-rich Cu-Au(-Zn-Ag) deposits of the Punta del Cobre belt, Chile. Hydrothermal alteration associated with mineralization and/or contact metamorphism caused by the Coastal Batholith exposed in the west resulted in new mineral assemblages and significant changes in the geochemical composition of its rocks. This paper presents a redefinition of the Punta del Cobre Formation and discusses its geologic context. The Punta del Cobre Formation is subdivided, from bottom to top, into: (1) the 'Geraldo-Negro Member', composed mainly of massive andesitic volcanic rocks (>300 m) and locally dacitic rocks (up to 200 m) that overlie the latter, and (2) the 'Algarrobos Member' (up to >800 m) comprising mainly volcaniclastic rocks, basalt andesitic and basaltic flows, and volcanic breccias. The Punta del Cobre Formation is overlain by the Chañarcillo Group, the lowest part of which is represented by alternating carbonate and volcaniclastic beds of the Abundancia Formation, which pass vertically and laterally into limestones of the Nantoco Formation. The contact between the Punta del Cobre Formation and the overlying Abundancia Formation is transitional and defined by the first continuous bed of massive limestone or its metamorphosed equivalent. A pre-upper Valanginian age for the Punta del Cobre Formation is suggested by ammonites of Berriasian age found in the upper part of the Algarrobos Member and Late Valanginian-Early Hauterivian fauna in the overlying Abundancia Formation. Despite the intense alteration, immobile element compositions of the volcanic rocks of the Punta del Cobre Formation enable the recognition of a calc-alkaline suite with a trend to more primitive, less differentiated magmas towards the top of the stratigraphic sequence, reflecting initial stages of basin development. The transgressive nature of the sedimentary part of the Punta del Cobre Formation marks the onset of increased subsidence that eventually

  3. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    PubMed Central

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  4. Del Norte means north to recycling

    SciTech Connect

    Aquino, J.T.

    1998-06-01

    Del Norte Regional Recycling and Transfer Station is owned by the city of Oxnard, California and operated by BLT Enterprises, Inc. The Del Norte facility--located in southwestern Ventura County about an hour northwest of Los Angeles--processes polyethylene terephthalate (PET) and high-density polyethylene (HDPE) plastic containers, aluminum, steel, glass, old corrugated containers (OCC), newspapers, computer printout paper, white and colored ledger paper, coated book, supermix paper, telephone books, and old magazines. According to the company, there has been virtually no community opposition to the site. The facility has few neighbors, and those are agricultural. To keep the community relationship strong, the facility`s design and location all but eliminated odor and noise complaints. The building was designed against the prevailing wind pattern, and BLT processes odorous material fast. A misting system installed for dust suppression also can be used with a solution for odor control should the need arise.

  5. del, Einstein, Mach, Gamow, and Lanczos: Gödel's remarkable excursion into cosmology

    NASA Astrophysics Data System (ADS)

    Rindler, Wolfgang

    2009-06-01

    This article is an expanded version of a talk given at the International Symposium Celebrating the 100th Birthday of Kurt Gödel (Vienna, 2006). It seeks to trace the path which led this preeminent mathematical logician to discover one of the famous results of General Relativity, the rotating Gödel Universe. This universe has some remarkable properties, which gave the philosophers plenty to worry about. It allows a person to travel into his own past, with all the ensuing causal paradoxes; it allows no unique temporal ordering of events; and though Gödel's Universe is rigid and infinite, the Foucault pendulum planes everywhere in it rotate in unison, a clear affront to adherents of Mach's Principle. We also discuss some lesser known precursors in the field, who just missed discovering Gödel's universe. While the article gives all the necessary derivations in simplified form (for example, of the metric and its geodesics), much of it should be accessible to the general reader, who can simply skip most of the mathematics. [Reprinted, with permission, from Kurt Gödel and the Foundations of Mathematics: Horizons of Truth, edited by Matthias Baaz, Christos H. Papadimitriou, Dana S. Scott, Hilary Putnam, and Charles L. Harper, Jr. (Cambridge U. P., New York, 2009).

  6. B4 2 After, 3D Deformation Field From Matching Pre- To Post-Event Aerial LiDAR Point Clouds, The 2010 El Mayor-Cucapah M7.2 Earthquake Case

    NASA Astrophysics Data System (ADS)

    Hinojosa-Corona, A.; Nissen, E.; Limon-Tirado, J. F.; Arrowsmith, R.; Krishnan, A.; Saripalli, S.; Oskin, M. E.; Glennie, C. L.; Arregui, S. M.; Fletcher, J. M.; Teran, O. J.

    2013-05-01

    Aerial LiDAR surveys reconstruct with amazing fidelity the sinuosity of terrain relief. In this research we explore the 3D deformation field at the surface after a big earthquake (M7.2) by comparing pre- to post-event aerial LiDAR point clouds. The April 4 2010 earthquake produced a NW-SE surface rupture ~110km long with right-lateral normal slip up to 3m in magnitude over a very favorable target: scarcely vegetated and unaltered desert mountain range, sierras El Mayor and Cucapah, in northern Baja California, close to the US-México border. It is a plate boundary region between the Pacific and North American plates. The pre-event LiDAR with lower point density (0.013-0.033 pts m-2) required filtering and post-processing before comparing with the denser (9-18 pts m-2) more accurate post event dataset. The 3D surface displacement field was determined using an adaptation of the Iterative Closest Point (ICP) algorithm, implemented in the open source Point Cloud Library (PCL). The LiDAR datasets are first split into a grid of windows, and for each one, ICP iteratively converges on the rigid body transformation (comprising translations and rotations) that best aligns the pre- to post-event points. Perturbing the pre- and post-event point clouds independently with a synthetic right lateral inverse displacements of known magnitude along a proposed fault, ICP recovered the synthetically introduced translations. Windows with dimensions of 100-200m gave the best results for datasets with these densities. The simplified surface rupture photo interpreted and mapped in the field, delineates very well the vertical displacements patterns unveiled by ICP. The method revealed block rotations, some with clockwise and others counter clockwise direction along the simplified surface rupture. As ground truth, displacements from ICP have similar values as those measured in the field along the main rupture by Fletcher and collaborators. The vertical component was better estimated than the

  7. Aftershock Relocation and Shear Wave Splitting in the Yuha Desert Following the 4 April 2010 M7.2 El Mayor-Cucapah Earthquake Kayla A. Kroll (UCR), Elizabeth S. Cochran (USGS), Keith Richards-Dinger (UCR)

    NASA Astrophysics Data System (ADS)

    Kroll, K.; Cochran, E. S.; Richards-Dinger, K. B.

    2011-12-01

    Following the 4 April 2010 El Mayor-Cucapah earthquake, 8 temporary seismometers were installed in the Yuha Desert region north of the Mexican border. During the deployment period, between 6 April and 14 June 2010, over 4,000 aftershocks, within a 20km by 14km study area in the Yuha Desert, are reported in the SCEDC catalog. We relocate the aftershocks and also determine shallow crustal anisotropy to illuminate the complex fault structure in this region. We compute the double difference hypocenter relocations using hypoDD with both manually picked P and S phase arrivals and waveform cross-correlations. We test three velocity models based on the Imperial Valley profile from the SCEC Community Velocity Model, Version 4 (CVM-S4), including the original profile and the profile with a 10% and 20% velocity reduction in Vp/Vs. We use a jackknife test in which the relocations are recomputed with one of the 13 stations removed in each test to estimate horizontal and vertical relative errors. By comparison with the LSQR errors of hypoDD, we find that scaling the LSQR errors by the jackknife/ LSQR error ratio provides a better error estimate. We find that the Imperial Valley profile with a 10% velocity reduction results in the lowest location errors. The absolute and relative relocation errors were reduced by at least an order of magnitude when compared to the original SCEDC catalog locations. We then use statistical uncertainties in the data to identify simple structures in the cloud of earthquake relocations. This modified collapsing method employs principal component analysis to identify three types of structures that a set of closely located events is most likely associated with: point, line or plane. With this method, collapsed locations provide insight to the poorly understood geologic structures in the Yuha Desert. Additionally, we measure the shallow crustal anisotropy using shear wave splitting techniques. Preliminary visual inspection of the data suggests clear

  8. Different styles of postseismic deformation after the 2013 M7.7 Balochistan earthquake in Pakistan and the 2010 M7.2 El Mayor-Cucapah earthquake in Mexico

    NASA Astrophysics Data System (ADS)

    Fielding, E. J.; Yague-Martinez, N.; Motagh, M.; Gonzalez-Ortega, J. A.; Huang, M. H.; Burgmann, R.; Freed, A. M.; Samsonov, S. V.

    2014-12-01

    We study postseismic deformation after the Mw 7.7 earthquake in the Balochistan region of western Pakistan on 24 September 2013 and the Mw 7.2 El Mayor-Cucapah (EMC) earthquake in Baja California of northern Mexico on 4 April 2010. Pakistan InSAR measurements from the German TerraSAR-X (TSX) and Canadian RADARSAT-2 (RS2) satellites include TSX narrow stripmap beams on a descending track, RS2 wide strip modes, and TSX wide-swath ScanSAR images on an ascending track, specially acquired with interferometric alignment of ScanSAR bursts. For the EMC earthquake, InSAR includes Envisat, ALOS, and RS2 satellites and NASA/JPL UAVSAR airborne InSAR, with piece-wise time coverage. Plate Boundary Observatory acquires continuous GPS data and others collect campaign GPS. Interferograms show significant afterslip on both main ruptures in the first weeks and months, not masked by the atmospheric effects. Balochistan shallow afterslip reaches at least 10 cm in 2-4 months in the same area as the largest coseismic slip, but less near the aftershock activity. Rapid afterslip was observed primarily at the ends of the EMC mainshock rupture where the strike changes, with magnitudes up to 30 cm. Large variations of tropospheric water vapor complicate measurement of small long-wavelength deformation so we do time series analysis. We expect viscoelastic relaxation after these two strike-slip earthquakes to differ due to completely opposite tectonic settings: EMC earthquake in the Salton Trough rift and fast-moving strike-slip system, where crust and lithosphere are thin and hot with very shallow asthenosphere, and Balochistan earthquake in the shortening Makran accretional prism with much slower strike-slip deformation rates and cold and thick lithosphere of the subducting Arabian plate directly beneath it, so asthenosphere is much deeper. Studies have found rapid and large viscoelastic relaxation for the EMC quake, but we don't expect measurable relaxation in the Balochistan area in the

  9. Visualization of the Gödel universe

    NASA Astrophysics Data System (ADS)

    Buser, M.; Kajari, E.; Schleich, W. P.

    2013-01-01

    The standard model of modern cosmology, which is based on the Friedmann-Lemaître-Robertson-Walker metric, allows the definition of an absolute time. However, there exist (cosmological) models consistent with the theory of general relativity for which such a definition cannot be given since they offer the possibility for time travel. The simplest of these models is the cosmological solution discovered by Kurt Gödel, which describes a homogeneous, rotating universe. Disregarding the paradoxes that come along with the abolishment of causality in such space-times, we are interested in the purely academic question of how an observer would visually perceive the time travel of an object in Gödel's universe. For this purpose, we employ the technique of ray tracing, a standard tool in computer graphics, and visualize various scenarios to bring out the optical effects experienced by an observer located in this universe. In this way, we provide a new perspective on the space-time structure of Gödel's model.

  10. The Effects of Salinity and Sodium Adsorption Ratio on the Water Retention and Hydraulic Conductivity Curves of Soils From The Pampa del Tamarugal, Chile

    NASA Astrophysics Data System (ADS)

    Lagos, M. S.; Munoz, J.; Suarez, F. I.; Fierro, V.; Moreno, C.

    2015-12-01

    The Pampa del Tamarugal is located in the Atacama Desert, the most arid desert of the world. It has important reserves of groundwater, which are probably fed by infiltration coming from the Andes Mountain, with groundwater levels fluctuating between 3 and 10-70 m below the land surface. In zones where shallow groundwater exists, the capillary rise allows to have a permanently moist vadose zone, which sustain native vegetation such as the Tamarugos (Prosopis tamarugo Phil.) and Algarrobos (Prosopis alba Griseb.). The native vegetation relies on the soil moisture and on the evaporative fluxes, which are controlled by the hydrodynamic characteristics of the soils. The soils associated to the salt flats of the Pampa del Tamarugal are a mixture of sands and clays, which have high levels of sulfates, chloride, carbonates, sodium, calcium, magnesium, and potassium, with high pH and electrical conductivity, and low organic matter and cationic exchange capacity. In this research, we are interested in evaluating the impact of salinity and sodium adsorption ratio (SAR) on the hydrodynamic characteristics of the soil, i.e., water retention and hydraulic conductivity curves. Soils were collected from the Pampa del Tamarugal and brought to the laboratory for characterization. The evaporation method (HYPROP, UMS) was used to determine the water retention curve and the hydraulic conductivity curve was estimated combining the evaporation method with direct measurements using a variable head permeameter (KSAT, UMS). It was found that higher sodium concentrations increase the water retention capacity and decrease the soiĺs hydraulic conductivity. These changes occur in the moist range of the hydrodynamic characteristics. The soil's hydraulic properties have significant impact on evaporation fluxes, which is the mayor component of the water balance. Thus, it is important to quantify them and incorporate salt precipitation/dissolution effect on the hydrodynamic properties to correctly

  11. Morphology, geology and geochemistry of the "Salar del Gran Bajo del Gualicho" (Rio Negro, Argentina)

    USGS Publications Warehouse

    Angelucci, A.; Barbieri, M.; Brodtkorb, A.; Ciccacci, S.; Civitelli, G.; De Barrio, R.; Di, Filippo M.; Fredi, P.; Friedman, I.; Lombardi, S.; Schalamuk, A.I.; Toro, B.

    1996-01-01

    A multidisciplinary study of the Gran Bajo del Gualicho area (Rio Negro - Argentina) was carried out; the aim was to delineate its geological and geomorphological evolution and to estabilish the genesis of salts filling the depression. Climatic conditions were analized first to individuate their role in the present morphogenetic processes; moreover the main morphological features of present landscape were examined as well as the stratigraphy of the outcropping formations, and of the Gran Bajo del Gualicho Formation in particular. Finally, a possible geomorphological evolution of the studied area was traced. Geophysical analyses allowed to estabilish that the paleosurface shaped on the crystalline basement is strongly uneven and shows evidence of the strong tectonic phases it underwent. The result of isotope analyses confirmed that the salt deposits on the Gran Bajo del Gualicho bottom were produced by fresh water evaporation, while strontium isotope ratio suggested that such waters were responsible for solubilization of more ancient evaporitic deposits.

  12. Kurt Gödels Brünner Verwandte

    NASA Astrophysics Data System (ADS)

    Müller, Dora

    2007-11-01

    The author of this memoir Dora Müller (born 1920) belongs - as well as Kurt Gödel-to the German minority playing an important role in the past life of Brno. The marriage of his son included her among the Gödels collaterals. She was chemist, but also pianist, historician, participant of antinacist movement and iniciator of Czech-German understanding after war. Following her personal experiences, remembrances of Gödels relatives and documental materials, she evokes the atmosphere of broader family milieu of Kurt Gödel.

  13. Spectral Amplification Factors of Long-Period (3 to 10 s) Strong Ground Motions in and around the Los Angeles Basin during the Mw7.2 El Mayor-Cucapah Earthquake of April 4, 2010

    NASA Astrophysics Data System (ADS)

    Hatayama, K.; Kalkan, E.

    2012-12-01

    We evaluated spectral amplification factors of long-period ground motions (3 to 10 s) in the Los Angeles (LA) basin by computing Fourier spectral ratios of the basin sites with respect to the surrounding reference hard-rock sites from the Mw7.2 April 4, 2010 El Mayor-Cucapah earthquake records and presented period-specific (4, 6, 8 and 10 s) maps of amplification factors for the long periods. This earthquake was the first event providing many (236) high-quality recordings to study spatial variation of long-period amplification in the LA basin. We also tried numerical wave propagation simulations for two of the recent 3D seismic-velocity models for south California: SCEC (Southern California Earthquake Center) CVM (Community Velocity Model)-4.0 and CVM-H 6.2 to examine how these models account for the observed long-period amplification factors. Comparison of the period-specific maps of amplification factors between the observation and the simulation for the two velocity models shows that both CVM-4.0 and CVM-H 6.2 can roughly reproduce the observed amplification factors with the period range of 8 to 10 s in the LA basin. Concerning the shorter-period range (4 to 6 s), however, both of the two models leave more to be improved so that the observed amplification factors can be better simulated. We also find that CVM-4.0 has an advantage over CVM-H 6.2 in terms of the south-eastern part of the LA basin, because CVM-H 6.2 indicates non-observed large amplification there, while CVM-4.0 does not indicate the false amplification. For the period of 10 s, the largest amplification factor of about 5 was observed in the central part of the LA basin, which is well simulated in terms of good agreements between the observed and the simulated amplification factors. The simulation from the two velocity models also indicates the large amplification even in the San Gabriel (SG) valley, which disagrees with the observation. For 8 s, larger amplification factors of about 5 were observed

  14. An evening at "La Clinica del Pueblo".

    PubMed

    Shefsky, M L

    1986-01-01

    This article describes a typical evening at the Clinica del Pueblo in the Hispanic neighborhood of Adams-Morgan in Washington, D.c. The Clinical del Pueblo began operating in 1983 in response to the urgen medical needs of Central American refugees arriving in the Washington D.c. area. The refugees bring with them severe trauma, fear, and health problems caused by the civil was and exacerbated by inadequate or non-existant health services. Approximately 80,000 Salvadoran refugees live in the area. They do not receive adequate health care for 3 reasons. 1) Because the US goverment is unwilling to recognize them as true refugees, they live with the constant threat of deportatin back to the violence from which they have fled. 2) Refugees lack the ability to pay for private care. 3) Langauage and culture create frightening barriers to health care for the refugees. For those who do seek care, these barriers can lead to the inadequate or incomplete diagnoses and poor compliance and follow-up. Plenty International and the Central American Refugee Center responded to these problems by organizing a free clinic to provide not only medical care but also a training course for volunteers. The director of the clinic organizes the course, the classes are taught by a variety of people including the clinic's volunteer physicians, nurses, and public health educators as well as graduates of previus training courses and people from the wider community. The services of the clinic reach only a small portion of the population in need. However, the fact that free medical services are now available to some Central American refugees make the Clinica del Pueblo an important program.

  15. Huave de San Mateo del Mar, Oaxaca (Huave of San Mateo del Mar, Oaxaca).

    ERIC Educational Resources Information Center

    Mexico Coll. (Mexico City)

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Huave, an indigenous language of Mexico spoken in San Mateo del Mar, in the state of Oaxaca. The objective of collecting such a representative sampling of…

  16. Near Infrared Photometry of Nova Del 2013

    NASA Astrophysics Data System (ADS)

    Cass, C. A.; Carlon, L. R.; Corgan, T. D.; Dykhoff, A. D.; Gehrz, D. R.; Shenoy, P. D.

    2013-08-01

    Subjects: Infra-Red, Nova We report RIJHKLM photometry of Nova Del 2013 taken on August 28.13 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). Vega (alpha Lyrae) was used as the standard star. On this date we find: R = 5.6 +/- 0.1, I = 5.2 +/- 0.1, J = 4.5 +/- 0.1, H = 4.7 +/- 0.1, K = 4.7 +/- 0.1, L = 3.3 +/- 0.2, M = +1.8 +/- 0.3.

  17. Prevalencia y factores de riesgo para infecciones del tracto urinario de inicio en la comunidad causadas por Escherichia coli productor de betalactamasas de espectro extendido en Colombia

    PubMed Central

    Blanco, Victor M.; Maya, Juan J.; Correa, Adriana; Perenguez, Marcela; Muñoz, Juan S.; Motoa, Gabriel; Pallares, Christian J.; Rosso, Fernando; Matta, Lorena; Celis, Yamile; Garzon, Martha; Villegas, y María V.

    2016-01-01

    RESUMEN Introducción Las infecciones del tracto urinario (ITU) son frecuentes en la comunidad. Sin embargo, la información de aislamientos resistentes en este contexto es limitada en Latinoamérica. Este estudio tiene como objetivo determinar la prevalencia y los factores de riesgo asociados con ITU de inicio en la comunidad (ITU-IC) causadas por Escherichia coli productor de betalactamasas de espectro extendido (BLEE) en Colombia. Materiales y métodos Entre agosto y diciembre de 2011 se realizó un estudio de casos y controles en 3 instituciones de salud de tercer nivel en Colombia. Se invitó a participar a todos los pacientes admitidos a urgencias con diagnóstico probable de ITU-IC, y se les pidió una muestra de orina. En los aislamien-tos de E. coli se realizaron pruebas confirmatorias para BLEE, susceptibilidad antibiótica, caracterización molecular (PCR en tiempo real para genes bla, repetitive element palindromic PCR [rep-PCR], multilocus sequence typing [MLST] y factores de virulencia por PCR). Se obtuvo información clínica y epidemiológica, y posteriormente se realizó el análisis estadístico. Resultados De los 2.124 pacientes seleccionados, 629 tuvieron un urocultivo positivo, en 431 de estos se aisló E. coli, 54 fueron positivos para BLEE y 29 correspondieron a CTX-M-15. La mayoría de los aislamientos de E. coli productor de BLEE fueron sensibles a ertapenem, fosfomicina y amikacina. La ITU complicada se asoció fuertemente con infecciones por E. coli productor de BLEE (OR = 3,89; IC 95%: 1,10–13,89; p = 0,03). E. coli productor de CTX-M-15 mostró 10 electroferotipos diferentes; de estos, el 65% correspondieron al ST131. La mayoría de estos aislamientos tuvieron 8 de los 9 factores de virulencia analizados. Discusión E. coli portador del gen blaCTX-M-15 asociado al ST131 sigue siendo frecuente en Colombia. La presencia de ITU-IC complicada aumenta el riesgo de tener E. coli productor de BLEE, lo cual debe tenerse en cuenta para ofrecer

  18. 33 CFR 110.65 - Indian River Bay, Del.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Indian River Bay, Del. 110.65 Section 110.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point...

  19. 33 CFR 110.65 - Indian River Bay, Del.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Indian River Bay, Del. 110.65 Section 110.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point...

  20. 33 CFR 110.65 - Indian River Bay, Del.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Indian River Bay, Del. 110.65 Section 110.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point...

  1. Instantánea del cáncer colorrectal

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer colorrectal; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  2. Pastoral del Nino: Bringing the Abundant Life to Paraguayan Children

    ERIC Educational Resources Information Center

    Austin, Ann Berghout; Aquino, Cyle; Burro, Elizabeth

    2007-01-01

    Pastoral del Nino is transforming children's lives in rural Paraguay. Part of Pastoral Social (Catholic Social Services), Pastoral del Nino's primary focus is to bring "vida en abundancia" (the abundant life) to families by ensuring that mothers survive childbirth and children reach their first birthdays. In addition, the organization promotes…

  3. 33 CFR 110.65 - Indian River Bay, Del.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Indian River Bay, Del. 110.65... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing... State highway bridge across Indian River Inlet; thence 174°, 600 feet; thence 264°, 800 feet; thence...

  4. 33 CFR 110.111 - Marina del Rey Harbor, Calif.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marina del Rey Harbor, Calif. 110.111 Section 110.111 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.111 Marina del Rey Harbor, Calif. An area...

  5. Instantánea del sarcoma de Kaposi

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el sarcoma de Kaposi; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  6. [Strengths and future of the Revista Médica del Instituto Mexicano del Seguro Social].

    PubMed

    Fajardo-Dolci, Germán

    2014-01-01

    The journals of medicine arose as a communication tool more than 200 years ago. At the beginning, their nature was local; later, their aim was to spread medical information along the nation; and, finally, they sought to reach the world distribution. The Revista Médica del Instituto Mexicano del Seguro Social was published for the first time 52 years ago, and it has walked its way from local to international distribution. This journal has 23 000 subscribers, it is included in Medline and it reached a 0.112 SCImago Journal Rank in 2012. Its website receives around 200 000 visits monthly and 45 % are foreign visits. In the future, the peer review system is going to be strengthened, and the journal is going to offer audio, video, and applications to reinforce interactive participation between authors, readers in order to reach modernity and draw young new attention.

  7. Illuminating water and life: Emilio Del Giudice.

    PubMed

    Ho, Mae-Wan

    2015-01-01

    The quantum electrodynamics theory of water put forward by Del Giudice and colleagues provides a useful foundation for a new science of water for life. The interaction of light with liquid water generates quantum coherent domains in which the water molecules oscillate between the ground state and an excited state close to the ionizing potential of water. This produces a plasma of almost free electrons favoring redox reactions, the basis of energy metabolism in living organisms. Coherent domains stabilized by surfaces, such as membranes and macromolecules, provide the excited interfacial water that enables photosynthesis to take place, on which most of life on Earth depends. Excited water is the source of superconducting protons for rapid intercommunication within the body. Coherent domains can also trap electromagnetic frequencies from the environment to orchestrate and activate specific biochemical reactions through resonance, a mechanism for the most precise regulation of gene function.

  8. Illuminating water and life: Emilio Del Giudice.

    PubMed

    Ho, Mae-Wan

    2015-01-01

    The quantum electrodynamics theory of water put forward by Del Giudice and colleagues provides a useful foundation for a new science of water for life. The interaction of light with liquid water generates quantum coherent domains in which the water molecules oscillate between the ground state and an excited state close to the ionizing potential of water. This produces a plasma of almost free electrons favoring redox reactions, the basis of energy metabolism in living organisms. Coherent domains stabilized by surfaces, such as membranes and macromolecules, provide the excited interfacial water that enables photosynthesis to take place, on which most of life on Earth depends. Excited water is the source of superconducting protons for rapid intercommunication within the body. Coherent domains can also trap electromagnetic frequencies from the environment to orchestrate and activate specific biochemical reactions through resonance, a mechanism for the most precise regulation of gene function. PMID:26098522

  9. Estudio teórico del CO2. Orbitales de valencia y del ``core''

    NASA Astrophysics Data System (ADS)

    Olalla Gutiérrez, E.

    Hemos calculado las intensidades de las transiciones E1 a los miembros de las series de Rydberg con origen en los orbitales ``no enlazantes'' del dióxido de carbono, especie de conocida relevancia atmosférica. Se han computado, asimismo, los continuos de fotoionización correspondientes a los distintos canales de ionización, representándolos como densidad espectral de fuerza de oscilador frente a la energía del fotón incidente; mostramos los resultados df/dE para la fotoionización total de esta especie en el intervalo 15-60 eV. Todos los cálculos se han llevado a cabo mediante la formulación Molecular del Método de los Orbitales de Defecto Cuántico, MQDO [1,2]. La calidad de los resultados que presentamos se ha evaluado en base a la comparación con los datos, tanto experimentales como teóricos, disponibles en la bibliografía. El acuerdo encontrado es altamente satisfactorio

  10. [La Medicina del Lavoro: 100 volumes].

    PubMed

    Zocchetti, C

    2009-01-01

    With these pages La Medicina del Lavoro starts its 100th volume, so we have yet another historical occasion to celebrate the oldest occupational health journal in the world that is still publishing. Over the last few years we have had many occasions to celebrate, for example several anniversaries of the Journal (the 80th volume in 1989, 90 years in 1992, 100 years in 2001); the centenary of the foundation of the Clinica del Lavoro "Luigi Devoto" of Milan in 2001; the celebration of the 300 years' anniversary of the publication of De Morbis Artificum Diatriba by Bernardino Ramazzini, and we obviously hope to continue for many years to come in this positive outlook. One hundred volumes makes for a very large collection, with the highs and lows ofthe Journal's history (here we mean the variations in number of pages and physical size of the Journal). It is thanks to the Editors-in-chief(there have been very few so we can cite them all: Luigi Devoto, 1901-1936; Luigi Preti, 1936-1941; Enrico Vigliani, 1943-1992; e Vito Foà, 1992 to the present); the contributors who in various ways and with varying degrees of commitment but always with an exceptional personal participation, that it has been possible to reach 100 volumes, starting with C. Moreschi who, along with Luigi Devoto, was the first and sole editor at the Journal's foundation; up to the present extended and impressive editorial board; the printers (from the first. Tipografia Cooperativa, Via dei Molini in Pavia, to the latest: Casa Editrice Mattioli in Fidenza); the sponsors, including the most evident who, via advertising (rather limited as a matter offact), directly gave information about themselves, but also those who have often been or are behind the scenes, ensuring fundamental support which is not visible; content. articles, news, events, reports, ideas, opinions, photographs, tables, numbers... etc, which are really impossible to sum up. But the true collection which, for obvious reasons, cannot be

  11. 394delTT: a Nordic cystic fibrosis mutation.

    PubMed

    Schwartz, M; Anvret, M; Claustres, M; Eiken, H G; Eiklid, K; Schaedel, C; Stolpe, L; Tranebjaerg, L

    1994-02-01

    In a systematic screening for mutations in the gene encoding the cystic fibrosis transmembrane regulator among Danish cystic fibrosis (CF) patients, we identified a mutation in exon 3 (394delTT); this mutation was found to be relatively common in Denmark. We therefore screened for 394delTT in Sweden and Norway, where it turned out to be the second most frequent mutation, accounting for 4% of all CF mutations. It also occurs with a high frequency in Finland, but has not been found in larger surveys of mutations in the CFTR gene. Thus, 394delTT seems to be a specific Nordic CF mutation.

  12. La estructura dinámica del cinturón de Kuiper interior y la formación de Urano y Neptuno

    NASA Astrophysics Data System (ADS)

    Melita, M. D.; Brunini, A.

    De acuerdo a los más recientes estudios sobre la formación de Urano y Neptuno, éstos podrían haber sufrido una importante migración radial hacia el exterior, debido al intercambio de momento angular con los planetesimales presentes en esa región durante las últimas etapas de la formación del Sistema Solar. Esta migración radial habría tenido importantes consecuencias sobre la presente estructura dinámica del cinturón cometario de Kuiper. Tal como lo reflejan las observaciones, la mayoría de los cuerpos observados en el cinturón de Kuiper se encuentran en resonancia de movimientos medios exteriores con Neptuno, hecho que también se refleja en la presente órbita de Plutón. En el presente trabajo se estudia tanto numérica como analíticamente la influencia de la variación de las masas de Urano y Neptuno durante el proceso de migración sobre las probabilidades de captura en algunas de las resonancias exteriores de Neptuno. Se estudia también la influencia de encuentros gravitacionales mutuos sobre la estabilidad de las órbitas resonantes. Este estudio ofrece argumentos de plausibilidad para explicar por qué ninguno de los objetos descubiertos en el cinturón de Kuiper se encontraría en la resonancia 2:1.

  13. Living Legacy: A Conversation with Carolina Gomez del Valle.

    ERIC Educational Resources Information Center

    Montessori Life, 1993

    1993-01-01

    Carolina Gomez del Valle has been involved in training other Montessorians in Mexico, Chile, Nicaragua, Peru, and Taiwan. This interview explores her experiences with Montessori education and describes how she has woven her religious training and Montessori philosophy together. (PAM)

  14. Centro para la Salud Mundial (CGH) del NCI

    Cancer.gov

    El Centro para la Salud Mundial (CGH) del NCI coordina actividades de investigación y trabaja con socios nacionales e internacionales para comprender y enfrentar la carga que representa el cáncer a nivel mundial.

  15. Del Pueblo: A School That's "Customade" for Learning

    ERIC Educational Resources Information Center

    Cooper, Terry Touff

    1975-01-01

    The contributions made by Hispanic people to the development of the United States were emphasized through the use of a model bilingual/bicultural program produced by the Del Pueblo Elementary School in Denver, Colorado. (Author/RK)

  16. Se evitaron casi 800 000 muertes por descenso del tabaquismo

    Cancer.gov

    Programas y estrategias de control del tabaco del siglo XX fueron responsables de la prevención de más de 795 000 muertes por cáncer de pulmón en Estados Unidos de 1975 al 2000. Si todo el tabaquismo en este país hubiera cesado después de la publicación d

  17. 65. Photographer unknown March 1931 DEL NORTE COUNTY, SECTION B, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    65. Photographer unknown March 1931 DEL NORTE COUNTY, SECTION B, HIGHWAY 1, 1-DN-1-B #66A, STA. 166.0+00 WIDENED ROADBED BEFORE COVERING LOG CRIB, 3-31. BACK READS: WIDENING ROAD BED WITH LOGS, APPROX 30 SQUARE & 60 LONG ON DN-1 SEC B STA 156+. Stamped office copy, - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  18. V339 Del (Nova Del 2013) is a weak non-super-soft X-ray source

    NASA Astrophysics Data System (ADS)

    Page, K. L.; Beardmore, A. P.

    2013-09-01

    V339 Del (Nova Del 2013) is currently being monitored approximately daily by Swift-XRT. X-ray analysis has been complicated due to optical loading caused by photons from the very bright optical source. (For a discussion of optical loading in the XRT, see our help page.) At early times, the data were collected mainly in Windowed Timing mode to mitigate this issue, and no X-ray source was detected (ATel #5283, #5305, #5318).

  19. Alloimmunization of patients by blood units harboring distinct DEL variants.

    PubMed

    St-Louis, Maryse; Lebrun, André; Goldman, Mindy; Lavoie, Marianne

    2013-01-01

    The alloimmunization potential of many RHD variants is unknown, and it can be explored by lookback and traceback studies. Hema-Quebec (HQ) investigated the RHD status of 3980 D- repeat blood donors. Thirteen were found to be RHD positive: 4 RHD*1p, and 1 RHD*487delACAG, which show a Dphenotype;and 1 RHD*885T and 7 RHD*(93-94insT) causing a DEL phenotype when C antigen is present. Look back studies were done to verify the alloimmunization potential of these eight DEL donors. Coincidentally, Canadian Blood Services (CBS)performed a trace back study by investigating the RHD status of donors after aD- recipient developed anti-Dafter transfusion of two D- red blood cell (RBC) units. Donor genotyping was done either manually (HQ) or using the Progenika Bloodchip platform(CBS). Donations were traced through computer records. Letters were sent to hospital blood bank physicians to verify the presence of anti-Din recipients and to donors to request repeat samples.A total of 118 RBC units were transfused, 82 to D- recipients.Anti-D was found in three patients transfused with RHD*(93-94insT) DEL red blood cells. One donor presenting the same DEL variant was involved in the trace back study. Even without strong evidence clearly demonstrating the alloimmunization potential of DEL variants, whenever HQ or CBS identifies a donor harboring a DEL phenotype, his or her D status will be changed from DtoD+ to protect against the potential alloimmunization risk. PMID:24689683

  20. May Gödel's Ideas Be Addressed Philosophically?

    NASA Astrophysics Data System (ADS)

    Dokulil, Miloš

    2007-11-01

    del emphasised philosophy as an important tool in science. Much less is known about his religious background. We should bear in mind that our evaluational perspective differs very much from the one in which Gödel lived. He was personally sure that there must be another existence after death-an afterlife (''of unlimited life span''). As a ''Baptized Lutheran'' he did not include ''Trinity'' in his creed. He was also certain that mind is separate from matter. This text tries to include Libet's ''readiness potential'' into the debate concerning the specificity of the mind. Neither Gödel's identification of materialism with mechanism nor his vision of the ''spirit'' are a viable solution of the problem.

  1. Estudio multifrecuencia del medio interestelar cercano a HD 192281

    NASA Astrophysics Data System (ADS)

    Arnal, E. M.; Cappa, C.; Cichowolski, S.; Pineault, S.; St-Louis, N.

    Una de las causas que modifica la estructura y dinámica del medio interestelar es la acción que los vientos de las estrellas de gran masa ejercen sobre el mismo. En este trabajo, mediante el uso de datos interferométricos obtenidos en la banda de radio en la transición de 21-cm del Hidrógeno neutro y de imágenes de la emisión de continuo en las bandas de 408 y 1420 MHz, de imágenes HIRES del satélite IRAS en 60 y 100 micrones, y de observaciones de continuo obtenidas con radiotelescopios de disco simple en 2695, 4850 y 8350 MHz se ha realizado un estudio multifrecuencia de los efectos que los vientos estelares de HD 192281, una estrella de tipo espectral O5 Vn((f))p, han tenido sobre el medio interestelar que rodea a la misma.

  2. Photometric study of the binary system NN Del

    NASA Astrophysics Data System (ADS)

    Gómez-Forrellad, J. M.; Sánchez-Bajo, F.; Corbera-Subirana, M.; GarcÍa-Melendo, E.; Vidal-Sainz, J.

    We present the results of the differential V light curve analysis of NN Del. We show that NN Del is an EA eclipsing binary system with a period of 99.27 days and a highly eccentric orbit. Photometric solutions obtained using the Russell and the Wilson-Devinney models seem to indicate that both components are very similar in radii and luminosities (assuming a F5 spectral type). Constraints imposed on the V luminosity of the system by the HIPPARCOS data suggest that the components of the system could be subgiants instead of main sequence stars.

  3. Outcome following haematopoietic cell transplantation in patients with myelodysplasia and del (5q) karyotypes.

    PubMed

    Stewart, B; Verdugo, M; Guthrie, K A; Appelbaum, F; Deeg, H J

    2003-12-01

    The deletion (5q) karyotype [del (5q)] in patients with myelodysplastic syndrome (MDS) is considered a good risk feature, while the impact of del (5q) combined with other karyotypic abnormalities [del (5q)+] is less well defined. We analysed the outcome of haematopoietic cell transplants (HCT) in patients with MDS with del (5q) or del (5q)+. Fifty-seven patients, aged 6-72 years, with MDS and del (5q) abnormalities received HCT from related (n = 32) or unrelated (n = 25) donors. By French-American-British (FAB) criteria, 27 patients had refractory anaemia (RA), 10 RA with excess blasts (RAEB), eight RAEB in transformation (RAEB-T) and 12 acute myeloid leukaemia evolving from MDS (tAML). Non-relapse mortality at 1-year post-transplantation was 30% for del (5q) and 38% for del (5q)+ patients. Relapse occurred in one of 20 del (5q) patients and 15 of 37 del (5q)+ patients (P = 0.001). After adjusting for del (5q) status, blast count (<5%) was the only factor significantly associated with relapse-free survival. Patients with del (5q), either as a '5q- syndrome' or with MDS in general, had better outcomes than did patients with del (5q)+. The indication for transplantation in patients with del (5q) was generally severe cytopenias, compared with disease progression to a more advanced FAB stage in patients with del (5q)+. Conceivably, outcome for patients with del (5q)+ would be improved with transplantation earlier in the disease course. PMID:14632779

  4. Síntesis: Resultados iniciales del Estudio Nacional de Ex

    Cancer.gov

    El 4 de noviembre de 2010, el Estudio Nacional de Exámenes de Pulmóndio a conocer resultados iniciales que indican que hubo 20% menos muertes por cáncer de pulmón entre los participantes del estudio evaluados con tomografía computarizada espiral de baja d

  5. Cosmogenic Radionuclides in the Campo Del Cielo Iron Meteorite

    NASA Technical Reports Server (NTRS)

    Liberman, R. G.; FernandezNiello, J. O.; Reedy, R. C.; Fifield, L. K.; diTada, M. L.

    2001-01-01

    Cosmogenic Be-10, Al-26, Cl-36, Ca-41, and Ni-59 were measured in the Campo del Cielo iron meteorite. Our results led us to conclude that the pre-atmospheric radius might have been approximately 2 m. Comparisons with other big bodies are also presented. Additional information is contained in the original extended abstract.

  6. 75 FR 21220 - Del Norte Resource Advisory Committee (RAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... agency #0;statements of organization and functions are examples of documents #0;appearing in this section...; ] DEPARTMENT OF AGRICULTURE Forest Service Del Norte Resource Advisory Committee (RAC) AGENCY: Forest Service... Rivers National Forest, 1330 Bayshore Way, Eureka, CA 95503 (707) 441-3673; e-mail...

  7. Design, aerodynamics and autonomy of the DelFly.

    PubMed

    de Croon, G C H E; Groen, M A; De Wagter, C; Remes, B; Ruijsink, R; van Oudheusden, B W

    2012-06-01

    One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the DelFly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the DelFly illustrate some of the properties of the top-down approach, which allows the identification and resolution of issues that also play a role at smaller scales. A parametric variation of the wing stiffener layout produced a 5% more power-efficient wing. An experimental aerodynamic investigation revealed that this could be associated with an improved stiffness of the wing, while further providing evidence of the vortex development during the flap cycle. The presented experiments resulted in an improvement in the generated lift, allowing the inclusion of a yaw rate gyro, pressure sensor and microcontroller onboard the DelFly. The autonomy of the DelFly is expanded by achieving (1) an improved turning logic to obtain better vision-based obstacle avoidance performance in environments with varying texture and (2) successful onboard height control based on the pressure sensor. PMID:22617112

  8. Design, aerodynamics and autonomy of the DelFly.

    PubMed

    de Croon, G C H E; Groen, M A; De Wagter, C; Remes, B; Ruijsink, R; van Oudheusden, B W

    2012-06-01

    One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the DelFly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the DelFly illustrate some of the properties of the top-down approach, which allows the identification and resolution of issues that also play a role at smaller scales. A parametric variation of the wing stiffener layout produced a 5% more power-efficient wing. An experimental aerodynamic investigation revealed that this could be associated with an improved stiffness of the wing, while further providing evidence of the vortex development during the flap cycle. The presented experiments resulted in an improvement in the generated lift, allowing the inclusion of a yaw rate gyro, pressure sensor and microcontroller onboard the DelFly. The autonomy of the DelFly is expanded by achieving (1) an improved turning logic to obtain better vision-based obstacle avoidance performance in environments with varying texture and (2) successful onboard height control based on the pressure sensor.

  9. Faculty Activity Analysis in the Universidad Tecnica Del Estado Campuses.

    ERIC Educational Resources Information Center

    Karadima, Oscar

    An analysis of academic activities of college faculty at the eight campuses of Chile's Universidad Tecnica del Estado was conducted. Activities were grouped into seven categories: direct teaching, indirect teaching, research, community services, faculty development, academic administration, and other activities. Following the narrative…

  10. 78 FR 50025 - Del Norte County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ...The Del Norte County Resource Advisory Committee (RAC) will meet in Crescent City, California on the dates listed below. The Committee is authorized under the Secure Rural Schools and Community Self-Determination Act (Act) (Pub. L. 112-141) and operates in compliance with the Federal Advisory Committee Act (FACA) (Pub. L. 92- 463). The purpose of the Committee is to improve collaborative......

  11. Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).

    ERIC Educational Resources Information Center

    Ford-Guerrera, Rebecca

    This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math computation, map…

  12. Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).

    NASA Astrophysics Data System (ADS)

    Menéndez, J. M.; Martín, I.; Velasco, A. M.

    El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

  13. Blackstone Valley Prep Mayoral Academy: BVP High School

    ERIC Educational Resources Information Center

    EDUCAUSE, 2015

    2015-01-01

    This Rhode Island charter high school serves an intentionally diverse population of students from two urban and two suburban communities. The blended learning model is tailored by grade level and emphasizes differentiation, deeper learning in a community, and assessment. The two-page grantee profiles from Next Generation Learning Challenges (NGLC)…

  14. [Polycyclic aromatic hidrocarbons deposition in the Milazzo-Valle del Mela (Sicily Region, Southern Italy) high-risk area following an oil refinery fire].

    PubMed

    Grechi, Daniele; Biggeri, Annibale

    2016-01-01

    On September 2014, a fire began within an oil refinery involving a storage tank containing several hundreds of thousands cubic meters of virgin naphtha. Mayors of neighbouring municipalities asked the Epidemiology and Prevention Society "Giulio A. Maccacaro" to carry out an environmental survey in order to evaluate what was the nature and how dangerous was suspended dust deposited by the fumes. In the following days, after fire had been extinguished we conducted a sample survey on the presence of polycyclic aromatic hydrocarbons (PAH) and metals in particulate deposited on the soil on a radius of five kilometres from the refinery and we engaged the exposed population. The Milazzo-Valle del Mela (Sicily Region, Southern Italy) high-risk area includes several industrial plants; among them, an oil refinery and a fuel powered energy plant. As reference area we selected the Sarroch municipality (Sardinia Region, Southern Italy), in the coast of the Tyrrhenian Sea, which is geographically comparable, where a large oil refinery is located and where an environmental campaign with measurement of PAH and metals in particulate matter was ongoing. Qualitatively, metal composition of particulate matter resulted similar in the Sarroch and Milazzo samples. Instead, a large excess of PAH was documented in the Milazzo samples as compared to the Sarroch ones. In conclusion, the results of the analysis of the samples of particulate matter deposited in the Milazzo area in the days immediately following the oil refinery fire showed a high quantity of PAH, carcinogenic substances which pose major hazard to population health. The greater fall-out was registered in the proximity of the burnt storage tank and the West neighbourhood, and at lesser extent in the Southern neighbourhood. As a consequence, there was a population exposure to carcinogenic substances which could have reached the food chain. PMID:26951697

  15. Analisis del contenido curricular de los Documentos Normativos del Programa de Ciencias en el area de biologia para la escuela superior del sistema de educacion publica de Puerto Rico: 1993-2012

    NASA Astrophysics Data System (ADS)

    Davila Montanez, Melissa

    Esta investigacion de naturaleza cualitativa se ocupo de realizar un analisis de contenido documental de los Documentos Normativos del Programa de Ciencias en el area de biologia de la escuela superior del sistema de educacion publica de Puerto Rico del periodo 1993-2012. Los documentos analizados fueron: Guia Curricular, 1995; Marco Curricular, 2003; Estandares de Excelencia, 1996, 2000 y Estandares de Contenido y Expectativas de Grado, 2007. Se indago si hubo cambios en significados en los Componentes Estructurales: Naturaleza de la ciencia, Paradigmas para la ensenanza de la ciencia, Funcion del curriculo formal, Mision de la ensenanza de la ciencia; Contenidos, destrezas y competencias, Estrategias de ensenanza y Evaluacion/Assessment del aprendizaje. El analisis sugiere que no hubo cambios sustanciales en los significados de los Componentes Estructurales. Los documentos estudiados muestran mayormente caracteristicas similares, aunque los documentos mas recientes eran mas descriptivos, explicativos y especificos.

  16. Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q).

    PubMed

    Zhang, Rui; Kim, Young-Mi; Wang, Xianfu; Li, Yan; Lu, Xianglan; Sternenberger, Andrea R; Li, Shibo; Lee, Ji-Yun

    2015-01-01

    The most common chromosomal abnormalities in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are -5/del(5q) and -7/del(7q). When -5/del(5q) and -7/del(7q) coexist in patients, a poor prognosis is typically associated. Given that -5/del(5q) and/or -7/del(7q) often are accompanied with additional recurrent chromosomal alterations, genetic change(s) on the accompanying chromosome(s) other than chromosomes 5 and 7 may be important factor(s) affecting leukemogenesis and disease prognosis. Using an integrated analysis of karyotype, FISH and array CGH results in this study, we evaluated the smallest region of overlap (SRO) of chromosomes 5 and 7 as well as copy number alterations (CNAs) on the other chromosomes. Moreover, the relationship between the CNAs and del(5q) and -7/del(7q) was investigated by categorizing the cases into three groups based on the abnormalities of chromosomes 5 and 7 [group I: cases only with del(5q), group II: cases only with -7/del(7q) and group III: concurrent del(5q) and del(7q) cases]. The overlapping SRO of chromosome 5 from groups I and III was 5q31.1-33.1 and of chromosome 7 from groups II and III was 7q31.31-q36.1. A total of 318 CNAs were observed; ~ 78.3% of them were identified on chromosomes other than chromosomes 5 and 7, which were defined as 'other CNAs'. Group III was a distinctive group carrying the most high number (HN) CNAs, cryptic CNAs and 'other CNAs'. The loss of TP53 was highly associated with del(5q). The loss of ETV6 was specifically associated with group III. These CNAs or genes may play a secondary role in disease progression and should be further evaluated for their clinical significance and influence on therapeutic approaches in patients with MDS/AML carrying del(5q) and/or -7/del(7q) in large-scale, patient population study. PMID:26392809

  17. The first century of the "clinica del lavoro" in Milan.

    PubMed

    Bertazzi, Pier Alberto; Foà, Vito

    2005-01-01

    The Clinica del Lavoro was created in Milan at the beginning of the 20th century by Luigi Devotto, who deemed it essential for physicians and health researchers to get involved in the life and health problems of working populations. The main roles of the Clinica del Lavoro were to educate medical students and train physicians; study actual workplaces, examine health and safety hazards and their noxious effects; and create initiatives and services to protect and promote workers' health. Important scientific contributions were made in several fields, including chemical carcinogenesis, effects of mineral and biologicalfibers, mechanism of action of silica dust, methods for the detection and measurements of toxic substances in both the work environment and workers' biological media.

  18. New records of fishes at Isla del Coco, Costa Rica

    USGS Publications Warehouse

    Garrison, V.H.

    1996-01-01

    Isla del Coco lies at 5 degrees 32'N latitude, 87 degrees 04'W longitude and is the sole peak of the Cocos Ridge exposed above sea level. This isolated island formed approximately 2 million years ago. It rises 575 m above the surface of the sea and covers 46 km2 (Castillo et aI., 1988). Five hundred km to the NNE is Costa Rica; 630 km SSW are the Galapagos Islands; 650 km to the E is Isla Malpelo, Colombia; and approximately 8,000 km W lie the Line Islands. Costa Rica claimed Isla del Coco in 1832 and declared it a National Park in 1978. The area of the park was increased to include the adjacent waters 5 km offshore in 1984 and 25 km offshore in 1991.

  19. Biological and behavioral determinants of fertility in Tierra del Fuego.

    PubMed

    Pascual, J; García-Moro, C E; Hernández, M

    2005-05-01

    The reproductive history of 182 women in postreproductive life or near menopause from the Chilean part of Tierra del Fuego was traced back by means of familial interviews. These postmenopausal women represent the population since almost the beginning of the settlement, and their reproductive years were spent on the island. Path analysis was applied to analyze fertility determinants of these women and to propose a complex model of interconnections among factors. The reproductive history of these women is characterized by a long fertile span, a short childbearing period, and low fertility. Age at menarche is relatively late, and the age of the women at first birth is mainly determined by their late age at marriage. The use of contraception is related to both spacing and stopping behaviors. The late age of women at marriage, the rhythm of conception, and practices of contraception are proposed as the main determinants of fertility in Tierra del Fuego.

  20. A model of Nevado del Ruiz Volcano, Colombia

    NASA Astrophysics Data System (ADS)

    Williams, Stanley N.; Meyer, Hansjürgen

    A workshop was held at the Observatorio Vulcanologico de Colombia in Manizales, Colombia, March 28 to April 1, 1988, to review the accumulated data on the disastrous November 13, 1985, eruption and related activity of Nevado del Ruiz volcano (Figure 1). Approximately 30 scientists from eight countries presented data, developed a preliminary model, and addressed the future problems of Ruiz. The volcano (see Figure 2) erupted just prior to the meeting, covering the meeting site with 1-2 mm of ash.The workshop was convened by Stanley N. Williams (Louisiana State University, Baton Rouge) and Hansjürgen Meyer (Universidad del Valle, Cali, Colombia). A special volume of the Journal of Volcanology and Geothermal Research is planned for the papers and letters presented at the workshop, with some additional contributions. Publication is expected in mid-1989.

  1. Solar adaptive optics at the Observatorio del Teide, Tenerife

    NASA Astrophysics Data System (ADS)

    Soltau, Dirk; Berkefeld, Thomas; Schmidt, Dirk; von der Lühe, Oskar

    2013-10-01

    Observing the Sun with high angular resolution is difficult because the turbulence in the atmosphere is strongest during day time. In this paper we describe the principles of solar adaptive optics exemplified by the two German solar telescopes VTT and GREGOR at the Observatorio del Teide. With theses systems we obtain near diffraction limited images of the Sun. Ways to overcome the limits of conventional AO by applying multiconjugate adaptive optics (MCAO) are shown.

  2. 2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  3. 3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY RECENT PEDESTRIAN BRIDGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  4. Field Measurements of Respiratory Del13CO2 and Photodegradation

    NASA Astrophysics Data System (ADS)

    van Asperen, H.; Sabbatini, S.; Nicolini, G.; Warneke, T.; Papale, D.; Notholt, J.

    2014-12-01

    Carbon decomposition dynamics have been studied in a variety of ecosystems and its variation can mostly be explained in terms of environmental variables (e.g. temperature and precipitation). However, carbon dynamics in arid, water limited regions have shown to be very different and are still largely unknown. Several studies have indicated the importance of photodegradation, the direct breakdown of organic matter by sunlight, in these arid regions. A FTIR (Fourier Transform Infrared Spectrometer) was set up to continuously measure concentrations of CO2, CH4, N2O, CO as well as del13C in CO2. The FTIR was connected to 2 different flux measurement systems: a Flux Gradient system and 2 flux chambers, providing a continuous data set of gas concentrations and biosphere-atmosphere gas fluxes at different heights and scales. Field measurements showed photodegradation induced carbon fluxes. Also, respiratory del13CO2 was determined by use of Keeling plots, and was determined to vary between -25‰ and -21‰. A clear diurnal pattern in respiratory del13CO2 was found, suggesting either different (dominant) respiratory processes between day and night or the effect of diffusive fractionation.

  5. Modeling Visibility in the EL Paso del Norte Region

    NASA Astrophysics Data System (ADS)

    Fitzgerald, R. M.; Medina, R.; DuBois, D. W.; Novlan, D.

    2013-12-01

    Poor visibility is a subject of growing public concern throughout the U.S, and an active area of research. Its societal impacts in air quality, aviation transport and traffic are significant. Aerosols play a fundamental role in the attenuation of solar radiation, and also affect visibility. The scattering and extinction coefficients of aerosol particles in the Paso del Norte Region have been calculated using the T- matrix model in conjunction with a laser particle counter. Inter-comparison of the model's results of the scattering and absorption coefficients against the corresponding data from a Photoacustic Extinctiometer instrument (which measures in-situ absorption and scattering coefficients of aerosol particles) shows excellent agreement. In addition, the volume-weighted method is used to determine the composite index of refraction which is representative of the aerosols for the Paso del Norte Airshed to obtain information of the type of aerosol particles present in the Airshed. The Single Scattering Albedo has also been retrieved using our methodology to obtain further insight into the type of aerosols present on a given day. Finally, the Koschmieder equation has been used to calculate the visual range or visibility, and was correlated with the PM2.5 and PM10 particle concentration present in the Airshed. Our methodology will allow a better understanding of the size and type of aerosol particles that are most detrimental to the visibility for the Paso del Norte Region.

  6. Los plaguicidas y la contaminacion del medio ambiente Venezolano

    USGS Publications Warehouse

    Stickel, L.F.; Stickel, W.H.

    1972-01-01

    RESUMEN DE RECOMENDACIONES Recomendaciones para el Programa de Investigacion: 1. Establecer un sistema de muestreo biologico para detectar los niveles tendencias de los productos quimicos toxicos en un peque?o numero de si tios representativos. 2. Mantener continua vigilancia de la contaminacion ambiental, mediante la seleccion acertadamente dirigida de las zonas afectadas y de las fuentes de contaminacion. 3. Realizar estudios acerca de las poblaciones de animales silvestres, y del exito de los procesos reproductivos de las especies o grupos clayes de animales que se consideran mas gravemente afectados. 4. Preparar recomendaciones para una accion gubernamental de proteccion al hombre, a la fauna silvestre y al medio ambiente. Recomendaciones para la Accion Administrativa: 1. Establecer limites a la tolerancia de los residuos de plaguicidas en los alimentos. Constituye una medida clave para disminuir la contaminacion ambiental. 2. Establecer normas de calidad del agua para las corrientes, represas, la gos y otros cuerpos. Es la segunda medida clave para reducir la contaminacion del ambiente 3. Exigir un tratamiento adecuado de los efluentes industriales, especialmente antes de que se construyan las nuevas plantas. 4. Exigir a los agricultores que en el uso de plaguicidas sigan los consejos tecnicos autorizados y negar a los vendedores el derecho a recomendar productos por su cuenta. 5. Tomar medidas para recoger y eliminar los recipientes y sobrantes de los plaguicidas.

  7. Estudio multifrecuencia del medio interestelar cercano a HD 192281

    NASA Astrophysics Data System (ADS)

    Arnal, E. M.; Cappa, C. E.; Cichowolski, S.; Pineault, S.; St-Louis, N.

    Una de las causas que modifica la estructura y dinámica del medio interestelar es la acción que los vientos de las estrellas de gran masa ejercen sobre el mismo. En este trabajo, mediante el uso de datos interferométricos obtenidos en la banda de radio en la transición de λ˜21-cm del hidrógeno neutro y de imágenes de la emisión de continuo en las bandas de 408 y 1420 MHz, de imágenes HIRES del satélite IRAS en 60 y 100μm, y de observaciones de continuo obtenidas con radiotelescopios de disco simple en 2695, 4850 y 8350 MHz se ha realizado un estudio multifrecuencia de los efectos que los vientos estelares de HD 192281, una estrella de tipo espectral O5,Vn((f))p, han tenido sobre el medio interestelar que rodea a la misma.

  8. Nova Del 2013 (V339 Del) is now a bright super-soft X-ray source

    NASA Astrophysics Data System (ADS)

    Osborne, Julian P.; Page, Kim; Beardmore, Andrew; Woodward, Chick; Schwarz, Greg; Bode, Mike; Ness, Jan-Uwe; Shore, Steve; Starrfield, Sumner; Wagner, Mark; Walter, Fred

    2013-10-01

    Regular Swift XRT monitoring of nova Del 2013 since our report in ATEL #5470 has revealed a decrease in the high absorbing column affecting the optically thin harder X-ray emission above 1 keV; spectral fits suggest N_H ~ 5x10^22 cm^-2 around day 45 and N_H ~ 1.8x10^22 around day 65 after discovery on Aug 14, 2013.

  9. The 2012 Reactivation of Nevado del Ruiz Volcano, Colombia

    NASA Astrophysics Data System (ADS)

    Ordoñez, M.; Lopez, C.; Cortes, G. P.; Londoño, J.; Battaglia, M.

    2012-12-01

    Nevado Del Ruiz volcano is most known for its tragic November 13, 1985 explosive event, when a small eruption produced an enormous lahar that buried and destroyed the town of Armero in Tolima, causing an estimated 25,000 deaths. Similar but less deadly incidents occurred in 1595 and 1845, again where a small explosive eruption was followed by a large lahar. Other minor explosive events occurred in 1805, 1828-9, and 1989. The Armero tragedy was a major factor in the establishment of a volcano monitoring program in Colombia. The network monitoring Nevado del Ruiz volcano has dramatically improved since the 1985 eruption and now includes geodetic, geophysical, geochemical and visual monitoring. The activity of Nevado Del Ruiz between 1985 and 1991 saw significant increases in seismicity and significant gas emissions with the main eruptive events of November 13, 1985 and September 1st, 1989. The volcano became seismically active again in 1995 and 2002, whit an increase in seismicity, without any gas emission or eruption. In October 2010 the volcano entered in a new phase of unrest with increased seismicity (HB events), deformation and gas emissions, likely associated with a new magma intrusion. In February, 2012 the volcano had a new and significant increase in seismicity (VT-LP), followed in May and June 2012 by small phreatic and phreato-magmatic eruption. This eruptive activity is still ongoing. Deformation measurements at Nevado Del Ruiz volcano have been carried out since just after the tragic eruption of the 13th of November 1985. In 2007 seven new electronic tilt meters were set up to monitor the deformation. Significant uplift was measured from August 2007 to October 2010, for a total cumulative value of more than 500 microradians. From the end of 2011 to July 2012, moderate changes of uplift were detected for a total of 70 microradians. The analysis of these deformation data shows a pattern of surface displacement associated with an intrusion of new magma

  10. Comportamiento del Helio en estrellas químicamente peculiares

    NASA Astrophysics Data System (ADS)

    Malaroda, S. M.; López García, Z.; Leone, F.; Catalano, F.

    Las estrellas químicamente peculiares (CP) se caracterizan por tener deficiencias y sobreabundancias de algunos elementos químicos de hasta 106 veces la abundancia solar. Además presentan variaciones en las líneas espectrales. Se piensa que ello se debe a que los campos magnéticos presentes en este tipo de estrellas son principalmente dipolares, con un eje de simetría diferente del eje de rotación. La distribución de los elementos sobreabundantes y deficientes no es homogénea sobre la superficie estelar y las variaciones observadas serían una consecuencia directa de la rotación estelar. Entre los elementos con abundancia anómala se encuentra el Helio, cuyas líneas tienen intensidades que no son consistentes con una abundancia normal, que no puede ser determinada del modo usual, o sea, considerando una atmósfera con composición solar. Con el fin de determinar la abundancia de este elemento, se inició un estudio de estrellas anómalas de Helio, Hew y He strong. Además se determinarán las abundancias de otros elementos anómalos como ser el Si, Cr, Mg, Mn y Fe. Las mismas se determinan del modo tradicional, o sea: a) medida de los anchos equivalentes de las líneas de los distintos elementos analizados; b) adopción de la temperatura efectiva, gravedad y abundancia del Helio; c) cálculo del modelo de atmósfera d) comparación con las observaciones y reinicio de un proceso iterativo hasta lograr un acuerdo entre todos los parámetros analizados. Las observaciones se llevaron a cabo en el Complejo Astronómico El Leoncito. Se observaron setenta y ocho estrellas anómalas de Helio. En este momento se está procediendo a calcular las abundancias correspondientes a los distintos elementos químicos. Para ello se hace uso de los modelos de Kurucz, ATLAS9. Los cálculos NLTE de las líneas de Helio se llevan a cabo con el programa MULTI y se compararán con los realizados con el programa WIDTH9 de Kurucz (LTE), con el objeto de resaltar la importancia de

  11. Perk Ablation Ameliorates Myelination in S63del-Charcot–Marie–Tooth 1B Neuropathy

    PubMed Central

    Musner, Nicolò; Sidoli, Mariapaola; Zambroni, Desireè; Del Carro, Ubaldo; Ungaro, Daniela; D’Antonio, Maurizio; Feltri, Maria L.

    2016-01-01

    In peripheral nerves, P0 glycoprotein accounts for more than 20% of myelin protein content. P0 is synthesized by Schwann cells, processed in the endoplasmic reticulum (ER) and enters the secretory pathway. However, the mutant P0 with S63 deleted (P0S63del) accumulates in the ER lumen and induces a demyelinating neuropathy in Charcot–Marie–Tooth disease type 1B (CMT1B)–S63del mice. Accumulation of P0S63del in the ER triggers a persistent unfolded protein response. Protein kinase RNA-like endoplasmic reticulum kinase (PERK) is an ER stress sensor that phosphorylates eukaryotic initiation factor 2 alpha (eIF2alpha) in order to attenuate protein synthesis. We have shown that increasing phosphophorylated-eIF2alpha (P-eIF2alpha) is a potent therapeutic strategy, improving myelination and motor function in S63del mice. Here, we explore the converse experiment: Perk haploinsufficiency reduces P-eIF2alpha in S63del nerves as expected, but surprisingly, ameliorates, rather than worsens S63del neuropathy. Motor performance and myelin abnormalities improved in S63del//Perk+/− compared with S63del mice. These data suggest that mechanisms other than protein translation might be involved in CMT1B/S63del neuropathy. In addition, Perk deficiency in other cells may contribute to demyelination in a non–Schwann-cell autonomous manner. PMID:27095827

  12. Screening for 185delAG in the Ashkenazim.

    PubMed Central

    Richards, C S; Ward, P A; Roa, B B; Friedman, L C; Boyd, A A; Kuenzli, G; Dunn, J K; Plon, S E

    1997-01-01

    A study was initiated to assess interest, educational effectiveness, and implications of genetic testing for the common BRCA1 mutation, 185delAG, in the Ashkenazim. Of 333 individuals who attended group sessions, 309 (92%) participated in the study. Participants were categorized as having negative family history (67%), positive family history (defined, by a relaxed criterion, as one first-degree relative or two second-degree relatives with breast [premenopausal] or ovarian cancer) (22%), positive personal history (7%), and both positive personal history and positive family history (4%). Group education was effective, as shown by the improvement in participant scores from pre- to posteducation tests. For the 289 individuals (94%) who requested testing, the major reasons included concern for their own risk, concern for the risk of their children, and desire to learn about surveillance options. The most common reason given by participants who declined testing was concern about health insurance. Six participants found to be heterozygous for the 185delAG mutation received results and were offered genetic counseling. Participants had consented for additional testing without receiving results and were screened for the 6174delT mutation in BRCA2, and seven were found to be positive. All identified carriers reported at least one first- or second-degree relative with a history of breast or ovarian cancer, although they did not all meet our study criteria for positive family history. Given these outcomes, we conclude that screening for breast and ovarian cancer susceptibility is most appropriate for individuals with a positive personal or positive family cancer history. We propose a guideline for future studies designed to identify individuals who may benefit from genetic testing for inherited breast and ovarian cancer. Images Figure 1 PMID:9150156

  13. Non-seasonality of births in Tierra del Fuego (Chile).

    PubMed

    Pascual, J; García-Moro, C; Hernández, M

    2000-01-01

    Tierra del Fuego is situated at the southern tip of the American continent, which conditions its environmental and climatic characteristics. The colonizing population arrived, at the end of the 19th century, from other Chilean regions (particularly from Chiloé) and diverse European countries, especially Britain and Croatia, but also Germany, Spain and Italy. In the present study, the existence of a seasonal pattern in 5430 births registered in the Chilean population of Tierra del Fuego from 1890 to 1995 was analysed. The analysis showed no seasonal distribution of births in the periods 1890-1920 and from 1946 to the present day, a phenomenon rarely reported in the literature. The absence of seasonality in birth distribution could be related to the great diversity in the origins of the population's families, the constant renovation of this and the declining importance of the administrative capital of the province of Tierra del Fuego, Porvenir, in favour of Punta Arenas, capital of the Magellanic region. In the period of maximum development of the capital of the province, a seasonal pattern was detected with a peak in April and a trough in October, which corresponds with a maximum of conceptions in July and, in general, during the early southern winter and a decline in births from late spring to mid-summer, with a trough in January. This birth distribution is interpreted as a subordination of activity and social life to the annual sheep cycle. In addition to temporal trends, the influence on the observed patterns of environmental parameters, father's occupation, seasonality of marriage and the origin of the parents were analysed.

  14. Gynandromorphs in mosquitoes (Diptera: Culicidae) from Valle del Cauca, Colombia.

    PubMed

    Barreto, Mauricio; Burbano, María E; Barreto, Pablo

    2008-01-01

    Gynandromorphs of Culex nigripalpus Theobald (2), Cx. pedroi Sirivanakarn and Belkin (1) and Aedes albopictus (Skuse) (2) are described. Two individuals of the latter species were reared in the laboratory, while the remaining three specimens were wild-caught with different traps in rural areas in Valle del Cauca department, southwestern Colombia. All of the individuals were mounted on microscopic slides with Canada balsam. From each mosquito, main morphological characteristics are described and illustrated. Due to the paucity of information about this subject, these findings as well as other relevant cases are discussed.

  15. Optical photometry and spectroscopy of Nova Del 2013

    NASA Astrophysics Data System (ADS)

    Tomov, T.; Ilkiewicz, K.; Swierczynski, E.; Belcheva, M.; Dimitrov, D.

    2013-08-01

    We report optical BV photometry and spectroscopy of Nova Del 2013, carried out between August 14.88 UT and August 15.08 UT. Using a 60 cm Cassegrain telescope at the Nicolaus Copernicus University Observatory (Torun, Poland) we estimated the V brightness of the Nova to be 6.31+/-0.02 mag and 6.18+/-0.03 mag on Aug. 14.94 UT and Aug. 15.02 UT respectively. HD 194113 (F2, V=8.00 mag) was used as a comparison star.

  16. Albedo polarimétrico de asteroides del grupo Hungaria

    NASA Astrophysics Data System (ADS)

    Gil-Hutton, R.; Benavidez, P.

    La región del cinturón de asteroides en donde se encuentra el grupo de los Hungarias (a= 1.79 a 1.98 UA, i=15 a 40 grados) es la única zona donde es común encontrar objetos de tipo taxonómico E, caracterizados por altos albedos, colores relativamente neutros y espectros sin detalles. Este tipo de asteroides está relacionado espectralmente con ciertos meteoritos (aubritas) que indican la existencia de episodios de gran calentamiento que ocurrieron durante la formación del Sistema Solar. Como el espectro de los asteroides de tipo E es idéntico a los de tipo M y P, la única forma de clasificar un asteroide en alguno de estos tres tipos taxonómicos es mediante el albedo. En este trabajo se presentan resultados preliminares sobre la determinación polarimétrica de albedos para objetos de este grupo utilizando el polarímetro CASPROF de CASLEO.

  17. 66. Photographer unknown March 1920'S DEL NORTE COUNTY, SECTION B, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    66. Photographer unknown March 1920'S DEL NORTE COUNTY, SECTION B, HIGHWAY 1. 1-DN 1-B #9, CORDUROY DETOUR INTO CRESCENT CITY, 2-2 (3?). Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  18. Content Analysis Schedule for Bilingual Education Programs: Del Valle Bilingual Education Program.

    ERIC Educational Resources Information Center

    Ehrlich, Roselin; Shore, Marietta Saravia

    This content analysis schedule for the Del Valle Bilingual Education Program of Del Valle, Texas, presents information on the history, funding, and scope of the project. Included are sociolinguistic process variables such as the native and dominant languages of students and their interaction. Information is provided on staff selection and the…

  19. Instantánea del cáncer de páncreas

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de páncreas; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  20. Instantánea del cáncer de pulmón

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de pulmón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  1. Instantánea del cáncer de seno (mama)

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de seno (mama); así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  2. Elaphopsocoides, a new genus of Psocidae (Psocodea: ´Psocoptera´) from Valle del Cauca, Colombia.

    PubMed

    Román-P, Cristian; García Aldrete, Alfonso N; Obando, Ranulfo González

    2014-10-14

    Two new species of Elaphopsocoides n. gen. from Valle del Cauca, Colombia, are here described and illustrated. The new genus is related to Elaphopsocus Roesler, but differs from it mostly in the hypandrial projections and in phallosome structure. The female subgenital plate has a distinct, median, posterior projection. The types are deposited in the Entomology Museum, Universidad del Valle (MUSENUV), Santiago de Cali, Colombia.

  3. Instantánea del cáncer de tiroides

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de tiroides; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  4. Instantánea del cáncer de cuello uterino

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de cuello uterino; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  5. Instantánea del cáncer de próstata

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de próstata; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  6. Instantánea del cáncer de estómago

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de estómago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  7. 62. R.L.T., photographer November 1, 1934 DEL NORTE COUNTY, SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    62. R.L.T., photographer November 1, 1934 DEL NORTE COUNTY, SECTION D, HIGHWAY 1. REDWOOD CLEARING ON EXISTING LINE, 1-DN-71-A #26, R.L.T. 11-1-34. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  8. Primer registro para Peru del genero Nielsonia Young, 1977 (Hemiptera: Cicadellidae: Cicadellinae: Cicadellini)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    En este articulo se reporta por primera vez para el Peru una especies del genero Nielsonia Young, 1977, de material procedente del Departamento de Tumbes. El genero ha sido reportada anteriormente de Ecuador, como unico registro para Sudamerica, y America Central. El unico especimen hembra encontra...

  9. Instantánea del cáncer de esófago

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de esófago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  10. [Recommendations to improve the scientific communication process in the Revista Médica del IMSS].

    PubMed

    Álvarez, Ivón

    2016-01-01

    In order to improve the position of the Revista Médica del Instituto Mexicano del Seguro Social among the different journals, in this editorial we enumerate a series of recommendations to ameliorate the practices of the different actors who participate in the scientific communication process of this journal.

  11. Instantánea del cáncer de ovario

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de ovario; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  12. 60. C.J.T., photographer December 23, 1955 KLAMATH RIVER BRIDGE, DEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    60. C.J.T., photographer December 23, 1955 KLAMATH RIVER BRIDGE, DEL NORTE COUNTY, SECTION A, HIGHWAY 1. DN-1-A #538, KLAMATH RIVER BR. FROM SO. END, 12/23/55, C.J.T. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  13. 63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION A, HIGHWAY 1. 1-DN A #124, STA. 164=00 SHOWING DRAINAGE CONDITIONS, G.F.H., 7-30-32. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  14. Instantánea del cáncer de endometrio

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de endometrio; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  15. [Recommendations to improve the scientific communication process in the Revista Médica del IMSS].

    PubMed

    Álvarez, Ivón

    2016-01-01

    In order to improve the position of the Revista Médica del Instituto Mexicano del Seguro Social among the different journals, in this editorial we enumerate a series of recommendations to ameliorate the practices of the different actors who participate in the scientific communication process of this journal. PMID:26820191

  16. Instantánea del cáncer de vejiga

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de vejiga; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  17. Instantánea del cáncer de riñón

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de riñón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  18. 33 CFR 162.40 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... section in 33 CFR part 207. ... River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal). 162.40 Section 162.40 Navigation... Bay, Del. and Md. (Chesapeake and Delaware Canal). (a) Applicability. The regulations in this...

  19. Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect

    PubMed Central

    Colas, Julien; Faure, Grazyna; Saussereau, Emilie; Trudel, Stéphanie; Rabeh, Wael M.; Bitam, Sara; Guerrera, Ida Chiara; Fritsch, Janine; Sermet-Gaudelus, Isabelle; Davezac, Noëlie; Brouillard, Franck; Lukacs, Gergely L.; Herrmann, Harald; Ollero, Mario; Edelman, Aleksander

    2012-01-01

    We have previously reported an increased expression of cytokeratins 8/18 (K8/K18) in cells expressing the F508del mutation of cystic fibrosis transmembrane conductance regulator (CFTR). This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR. In the present work, we hypothesized that (i) the K8/K18 network may interact physically with CFTR, and that (ii) this interaction may modify CFTR function. CFTR was immunoprecipitated from HeLa cells transfected with either wild-type (WT) CFTR or F508del-CFTR. Precipitates were subjected to 2D-gel electrophoresis and differential spots identified by mass spectrometry. K8 and K18 were found significantly increased in F508del-CFTR precipitates. Using surface plasmon resonance, we demonstrate that K8, but not K18, binds directly and preferentially to the F508del over the WT human NBD1 (nucleotide-binding domain-1). In vivo K8 interaction with F508del-CFTR was confirmed by proximity ligation assay in HeLa cells and in primary cultures of human respiratory epithelial cells. Ablation of K8 expression by siRNA in F508del-expressing HeLa cells led to the recovery of CFTR-dependent iodide efflux. Moreover, F508del-expressing mice topically treated with K8-siRNA showed restored nasal potential difference, equivalent to that of WT mice. These results show that disruption of F508del-CFTR and K8 interaction leads to the correction of the F508del-CFTR processing defect, suggesting a novel potential therapeutic target in CF. PMID:22038833

  20. Instantánea de los cánceres de cerebro y del sistema nervioso central

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre los cánceres de cerebro y del sistema nervioso central; así como ejemplos de actividades del NCI y adelantos en la investigación de estos tipos de cáncer.

  1. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and navigation. (a... River to Chesapeake Bay, Del. and Md., between Reedy Point, Delaware River, and Old Town Point...

  2. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and navigation. (a... River to Chesapeake Bay, Del. and Md., between Reedy Point, Delaware River, and Old Town Point...

  3. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and navigation. (a... River to Chesapeake Bay, Del. and Md., between Reedy Point, Delaware River, and Old Town Point...

  4. Assessing Glacier Hazards At Ghiacciaio Del Belvedere, Macugnaga, Italian Alps

    NASA Astrophysics Data System (ADS)

    Haeberli, W.; Chiarle, M.; Mortara, G.; Mazza, A.

    The uppermost section of the Valle Anzasca behind and above the community of Macugnaga in the Italian Alps is one of the most spectacular high-mountain land- scapes in Europe, with gigantic rock walls and numerous steep hanging glaciers. Its main glacier, Ghiacciaio del Belvedere at the foot of the huge Monte Rosa east face, is a heavily debris-covered glacier flowing on a thick sediment bed. Problems with floods, avalanches and debris flows from this ice body have been known for extended time periods. Most recently, however, the evolution of this highly dynamic environ- ment has become more dramatic. An outburst of Lago delle Locce, an ice-dammed lake at the confluenec of the tributary Ghiacciaio delle Locce with Ghiacciaio del Belvedere, caused heavy damage in 1979 and necessitated site investigation and con- struction work to be done for flood protection. The intermittent glacier growth ten- dency in the 1970es induced strong bulging of the glacier surface and, in places, caused the glacier tongue to override historical morains and to destroy newly-grown forest stands. A surge-type flow acceleration started in the lower parts of the Monte- Rosa east face during summer 2000, leading to strong crevassing and deformation of Ghiacciaio del Belvedere and extreme bulging of its orographic right margin. High water pressure and accelerated movement lasted into winter 2001/2002: the ice now started overriding the LIA moraine near Rifugio Zamboni of the CAI. In addition but rather independently, a most active detachment zone for rock falls and debris flows developed for several years now in the east face of Monte Rosa, somewhat more to the south of the accelerated glacier movement and at an altitude where relatively warm permafrost must be expected. Besides the scientific interest in these phenomena, the growing hazard potential to the local infrastructure must be considered seriously. Es- pecially potentials for the destabilization of large rock and ice masses in the

  5. Ozone studies in the Paso del Norte region

    NASA Astrophysics Data System (ADS)

    Becerra-Davila, Fernando

    The Paso del Norte region forms the largest contiguous bi-national conglomerate on the US-Mexico border. With a combined population of around 2 million inhabitants, the Paso del Norte region is isolated, more than 500 km away from the nearest urban area of comparable size, thus making it an ideal location for air quality studies of an isolated urban environment. The meteorological conditions leading to a high ozone episode in this region, such as the historical ozone episode of June 2006, are analyzed. It is well known that stagnation and minimal winds, high temperatures, and pressure ridges over the region are conducive to high ozone episodes. In addition, the planetary boundary height is studied to understand its impact on high ozone episodes. Several studies report that ground level ozone non-attainment regulations could be caused not only by local emissions, but also by atmospheric transport. In this work the atmospheric advection of pollutants into the region is analyzed using HYSPLIT backward trajectories. Furthermore, a novel backward trajectory clustering technique is implemented for the summer of 2006. The "ozone weekend effect" (OWE) is a phenomenon by which in some geographical regions ambient ozone concentrations tend to be higher on weekends than on weekdays, despite the lower emissions of ozone precursors during those days. The observed local OWE has never previously been studied in terms of the photolysis rates of four of the main ozone precursors. In this research a novel method that allows the calculation of actinic fluxes, photolysis frequencies and photolysis rates with a high degree of accuracy and reliability has been developed. This method utilizes a combination of the experimental data available for this region in conjunction with a radiative transfer model (TUV model). Three weekend-weekday cases during summers 2006, 2009 and 2010 are studied in this work. In this research, the photolysis impact on the local OWE is studied. The results

  6. Renewable energy load assessment for Boquillas Del Carmen Coahuila, Mexico

    SciTech Connect

    Foster, R.

    1995-08-01

    This report outlines the estimates that were made in 1992 of the potential load requirements for Boquillas del Carmen, a small Mexican village on the northern border of the state of Coahuila, Mexico near Big Bend National Park in southern Texas. The study was made to help determine the possibility that village might be electrified by solar or wind energy. Various estimates of are given of the potential load based on estimates ranging from basic use of lights, radio, television, and small household appliances to microwave ovens, refrigerators, and direct evaporative coolers. The low-energy consumption case was estimated to be at 23.0 kWh/month per residence per month, and the high-energy consumption case (with cooling) was 140.7 kWh/month per residence. On average, the typical residence is occupied by five individuals.

  7. [History of Instituto Nacional de Salud Ocupacional del Peru].

    PubMed

    Cossio-Brazzan, Juan M

    2012-06-01

    In Peru, the industry's development has made economic improvements but at the same time, it has had a major impact on the health of the workers; for that reason, it was necessary to generate control mechanisms. So, in 1940 it was created the Departmento de Higiene Industrial, which in 1956 was changed to Instituto de Salud Ocupacional, but it was deactivated in 1994. However, in 2001 it reappeared into the Ministerio de Salud organizational structure with the name of Instituto de Salud Ocupacional "Alberto Hurtado Abadía". Actually, it is the Centro Nacional de Salud Ocupacional y Protección del Ambiente para la Salud (CENSOPAS), organ of the Instituto Nacional de Salud which continues working in synergy with other institutions and sectors, making research to protect the health of exposed persons (workers and community) to contamination and risks associated with economic activities. PMID:22858781

  8. Spatially Controlled Fe Isotope Variations at Torres del Paine

    NASA Astrophysics Data System (ADS)

    Gajos, N.; Lundstrom, C.

    2013-12-01

    Recent advances in mass-spectrometry have identified systematic trends of non-traditional stable isotope variation in igneous rocks with differentiation index. We present new Fe isotope data for the Torres del Paine igneous complex in southern Chile. The multi-composition pluton consists of a 1 km vertical exposure of homogenous granite overlying a contemporaneous and possibly cogenetic 0.5 km mafic gabbro suite. Whereas previous isotopic investigations do little to address variations across important magmatic contacts, this study focuses on a first-of-its-kind spatially dependent non-traditional stable isotope investigation of an igneous pluton. Samples were collected at Torres del Paine in spatially significant transects, focusing on major contacts between country rock, granite and mafic units. Results collected by bracketed double spike MC-ICP-MS (2s precision of ×0.03) show an increase in δ56Fe towards the high silica margins of the pluton with values as high as δ56Fe 0.36. Additionally, the data show a decrease in δ56Fe toward the mafic center of the pluton with δ56Fe values ranging from δ56Fe -0.05 to 0.18. Samples collected on the contact between the granite and mafic complex show intermediate values of δ56Fe= 0.18(×) 0.03. Country rock samples in contact with granite show an isotopically light signature of δ56Fe=0.04 (×) 0.03. Analysis of 50 samples in total show a trend of increasing δ56Fe with SiO2 content. The process responsible for Fe isotope variations remains debated but is suggested to reflect four mechanisms: (1) crustal assimilation, (2) fractional crystallization, (3) late stage fluid exsolution [1] and (4) thermal migration [3]. Preliminary results show that mechanisms #1 and #2 would produce isotopic signatures opposite of those seen at Torres del Paine and other plutonic rocks. Isotopically light Torres country rock samples reveal that assimilation of rocks would not produce the isotopically heavy granites seen at Torres. Based on

  9. Circular structures of Bajada del Diablo (Argentina): geophysical signatures

    NASA Astrophysics Data System (ADS)

    Prezzi, C. B.; Orgeira, M. J.; Martinez, O.; Acevedo, R. D.; Ponce, F.; Goldmann, G.; Magneres, I.; Rabassa, J.

    2016-05-01

    Bajada del Diablo is located in the Northern Patagonian Massif, Chubut, Argentina. The study area includes several circular structures found in Miocene olivine basalts of the Quiñelaf Eruptive Complex and in the Late Pliocene/Early Pleistocene Pampa Sastre conglomerates. An impact origin has been proposed for these circular structures. With the aim of further investigate the proposed impact origin, topographic, gravimetric, magnetic, resistivity, palaeomagnetic and electromagnetic surveys in two circular structures (`8' and `G') located in Pampa Sastre conglomerates and in basalts of the Quiñelaf Eruptive Complex were carried out. The new geophysical results support the hypothesis of an impact origin. However, the confirmation of such an origin through the findings of shock metamorphism evidences and/or the recovery of meteorites remains elusive.

  10. [History of Instituto Nacional de Salud Ocupacional del Peru].

    PubMed

    Cossio-Brazzan, Juan M

    2012-06-01

    In Peru, the industry's development has made economic improvements but at the same time, it has had a major impact on the health of the workers; for that reason, it was necessary to generate control mechanisms. So, in 1940 it was created the Departmento de Higiene Industrial, which in 1956 was changed to Instituto de Salud Ocupacional, but it was deactivated in 1994. However, in 2001 it reappeared into the Ministerio de Salud organizational structure with the name of Instituto de Salud Ocupacional "Alberto Hurtado Abadía". Actually, it is the Centro Nacional de Salud Ocupacional y Protección del Ambiente para la Salud (CENSOPAS), organ of the Instituto Nacional de Salud which continues working in synergy with other institutions and sectors, making research to protect the health of exposed persons (workers and community) to contamination and risks associated with economic activities.

  11. Phytoseiid mites (Acari: Phytoseiidae) from Patagonia and Tierra del Fuego.

    PubMed

    Ferragut, Francisco; Navia, Denise

    2015-07-28

    Predatory phytoseiid mites have been intensively studied and surveyed in the last decades because of their economic importance as biocontrol agents of agricultural pests. However, many regions of the world remain unexplored and the diversity of the family worldwide is still fragmentary. Up to date no phytoseiid species have been collected in the southernmost part of the Earth down to latitude 45º S. In this study Phytoseiidae were sampled from native vegetation in southern Argentina and Chile in the regions of Patagonia and Tierra del Fuego Island. Thirteen species were collected, five of which were previously described and eight, Chileseius australis n. sp., Neoseiulus mapuche n. sp., Typhlodromips valdivianus n. sp., T. fissuratus n. sp., Amblyseius grandiporus n. sp., A. caliginosus n. sp., Typhlodromus (Anthoseius) anomalos n. sp. and Metaseiulus parabrevicollis n. sp. are proposed as new to science and are described and diagnosed.

  12. Near-IR Photometry of Nova Del 2013

    NASA Astrophysics Data System (ADS)

    Cass, C. A.; Carlon, L. R.; Corgan, T. D.; Dykhoff, A. D.; Gehrz, D. R.; Shenoy, P. D.

    2013-08-01

    Subjects: Infra-Red, Nova We report Near-IR photometry of Nova Del 2013 taken with the 0.76-m infrared telescope at the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). RIJHKLM photometry were obtained on August 21.17 and 23.13 UT using an AsSi bolometer. Vega (alpha Lyrae) was used as the standard star. Our photometry show: August 21.17 UT: R = 5.1 +/- 0.1, I = 4.6 +/- 0.1, J = 4.6 +/- 0.1, H = 4.1 +/- 0.1, K = 3.9 +/- 0.1, L = 2.7 +/- 0.2, M = +2.2 +/- 0.2.

  13. Deglacial palaeoclimate at Puerto del Hambre, subantarctic Patagonia, Chile

    NASA Astrophysics Data System (ADS)

    Heusser, Calvin J.; Heusser, Linda E.; Lowell, Thomas V.; Moreira M., Andrés; Moreira M., Simón

    2000-02-01

    The primary objective of this study is to further substantiate multistep climatic forcing of late-glacial vegetation in southern South America. A secondary objective is to establish the age of deglaciation in Estrecho de Magallanes-Bahía Inútil. Pollen assemblages at 2-cm intervals in a core of the mire at Puerto del Hambre (53°3621S, 70°5553W) provide the basis for reconstructing the vegetation and a detailed account of palaeoclimate in subantarctic Patagonia. Chronology over the 262-cm length of core is regulated by 20 AMS radiocarbon dates between 14 455 and 10 089 14C yr BP. Of 13 pollen assemblage zones, the earliest representing the Oldest Dryas chronozone (14 455-13 000 14C yr BP) records impoverished steppe with decreasing frequencies and loss of southern beech (Nothofagus). Successive 100-yr-long episodes of grass/herbs and of heath (Empetrum/Ericaceae) before 14 000 14C yr BP infer deglacial successional communities under a climate of increased continentality prior to the establishment of grass-dominated steppe. The Bølling-Allerød (13 000-11 000 14C yr BP) is characterised by mesic grassland under moderating climate that with abrupt change to heath dominance after 12 000 14C yr BP was warmer and not as humid. At the time of the Younger Dryas (11 000-10 000 14C yr BP), grass steppe expanded with a return of colder, more humid climate. Later, with gradual warming, communities were invaded by southern beech. The Puerto del Hambre record parallels multistep, deglacial palaeoclimatic sequences reported elsewhere in the Southern Andes and at Taylor Dome in Antarctica. Deglaciation of Estrecho de Magallanes-Bahía Inútil is dated close to 14 455 14C yr BP, invalidating earlier dates of between 15 800 and 16 590 14C yr BP.

  14. [Epidemiology of dog bite lesions in Tierra del Fuego, Argentina].

    PubMed

    Zanini, Fabián; Padinger, Patricia; Elissondo, María C; Pérez, Héctor

    2008-01-01

    The coexistence between man and dog has resulted in mutual benefits during thousands of years, nevertheless some problems have recently arisen where bite injuries have an important role. The aim of this work was to describe the epidemiological characteristics of dog bite lesions which occurred during a year in Tierra del Fuego. A descriptive observational, transversal study of patients who were admitted with dog bite injuries to clinic and pediatric emergency services of hospitals and health centers was carried out between 3/1/05 and 3/1/06. A total of 382 records were made. The children group represents 49.5%. The group between 5 and 9 year-old was the most affected (44.4%; IC95% 37.2-51.8). In the adult group, that between 15 and 24 year-old was the most affected (29.5%; IC95% 23.2-36.5). More lesions were registered in men (57.6%) than in women (42.4%) (chi2 = 8.6, p = 0.003). During spring and summer months, 56.5% of the lesions were registered. A 72.8% of the incidents occurred on the public highway. Dogs of big size were responsible of 49.7% (IC95% 44.6-54.9) of the injuries. The 89.8% of the incidents were caused by another person's dog. Of the lesions, 55.8% (IC95% 50.6-60.8) were registered in lower extremities and 11% (IC95% 8.1-14.7) in head and neck. These data show that dog bite lesions affect the health and impact in the quality of life of the population of Tierra del Fuego, Argentina.

  15. DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates.

    PubMed

    Shin, Jieun; Maekawa, Tomoki; Abe, Toshiharu; Hajishengallis, Evlambia; Hosur, Kavita; Pyaram, Kalyani; Mitroulis, Ioannis; Chavakis, Triantafyllos; Hajishengallis, George

    2015-09-30

    DEL-1 (developmental endothelial locus-1) is an endothelial cell-secreted protein that regulates LFA-1 (lymphocyte function-associated antigen-1) integrin-dependent leukocyte recruitment and inflammation in various tissues. We identified a novel regulatory mechanism of DEL-1 in osteoclast biology. Specifically, we showed that DEL-1 is expressed by human and mouse osteoclasts and regulates their differentiation and resorptive function. Mechanistically, DEL-1 inhibited the expression of NFATc1, a master regulator of osteoclastogenesis, in a Mac-1 integrin-dependent manner. In vivo mechanistic analysis has dissociated the anti-inflammatory from the anti-bone-resorptive action of DEL-1 and identified structural components thereof mediating these distinct functions. Locally administered human DEL-1 blocked inflammatory periodontal bone loss in nonhuman primates-a relevant model of human periodontitis. The ability of DEL-1 to regulate both upstream (inflammatory cell recruitment) and downstream (osteoclastogenesis) events that lead to inflammatory bone loss paves the way to a new class of endogenous therapeutics for treating periodontitis and perhaps other inflammatory disorders. PMID:26424570

  16. DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates

    PubMed Central

    Shin, Jieun; Maekawa, Tomoki; Abe, Toshiharu; Hajishengallis, Evlambia; Hosur, Kavita; Pyaram, Kalyani; Mitroulis, Ioannis; Chavakis, Triantafyllos; Hajishengallis, George

    2015-01-01

    DEL-1 is an endothelial cell-secreted protein that regulates LFA-1-integrin–dependent leukocyte recruitment and inflammation in various tissues. Here we identified a novel regulatory mechanism of DEL-1 in osteoclast biology. Specifically, we showed that DEL-1 is expressed by human and mouse osteoclasts and regulates their differentiation and resorptive function. Mechanistically, DEL-1 inhibited the expression of NFATc1, a master regulator of osteoclastogenesis, in a Mac-1-integrin–dependent manner. In vivo mechanistic analysis has dissociated the anti-inflammatory from the anti-bone resorptive action of DEL-1 and identified structural components thereof mediating these distinct functions. Importantly, locally administered human DEL-1 blocked inflammatory periodontal bone loss in nonhuman primates—a relevant model of human periodontitis. The ability of DEL-1 to regulate both upstream (inflammatory cell recruitment) and downstream (osteoclastogenesis) events that lead to inflammatory bone loss paves the way to a new class of endogenous therapeutics for treating periodontitis and perhaps other inflammatory disorders. PMID:26424570

  17. Calibración del retardo ionosférico en observaciones astrométricas y geodésicas a partir de observaciones GPS

    NASA Astrophysics Data System (ADS)

    Brunini, C.; Kleusberg, A.; Arias, E. F.; de Biasi, M. S.

    Los parámetros astrométricos y geodésicos de precisión se determinan hoy mediante la observación con técnicas espaciales (VLBI, GPS y LSR). Las técnicas VLBI y GPS operan en la banda de microondas y en ella la ionósfera terrestre es dispersiva. Las señales que provienen de las radiofuentes y de los satélites atraviesan la ionósfera, donde el índice de refracción difiere de la unidad en una cantidad que es proporcional a la densidad de electrones libres e inversamente proporcional al cuadrado de la frecuencia de la onda portadora. Actualmente el International GPS Service for Geodynamics (IGS) mantiene operacional una red global integrada por más de 50 estaciones equipadas con receptores GPS de alta performance; las observaciones diarias son accesibles a los usuarios mediante ftp. La posibilidad de utilizar estas observaciones en un monitoreo continuo de la ionósfera fue señalada por diversos autores, razón por la cual en los últimos años se ha invertido un significativo esfuerzo en la producción de mapas ionosféricos regionales y globales. En el presente trabajo se utilizan 28 estaciones cuyas observaciones mapean la mayor parte de la ionósfera global. Los resultados obtenidos demuestran la posibilidad de obtener mapas ionosféricos globales con una resolución de medio día y con una precisión de (1.5 nseg (rms)). Dichos mapas proveen valores medios globales para el intervalo ajustado. Los residuos del ajuste por mínimos cuadrados constituyen una señal a partir de la cual pueden estudiarse mejor las variaciones geográficas de la ionósfera y las componentes estadísticas de su variación temporal.

  18. Spatial shell structure of the novas DQ Her and HR Del

    SciTech Connect

    Pilyogin, L.S.

    1986-03-01

    This paper considers the formation of the spatial shell structure of the novas DQ Her (1934) and HR Del (1967). It is shown that the existence of polar caps is due to the influence of the second component of the system on the angular distribution of the mass shell depth of the mainshell. The ratio of the mass shell depth in the equatorial ring and in the polar caps is 1.13 for DQ Her and 2.7 for HR Del. The ratio of the maximal densities in the equatorial ring and the polar caps is of order 3 for DQ Her and of order 70 for HR Del.

  19. Resultados del relevamiento de HI en el Cielo Austral: 3. Relevamiento de Nubes de Alta Velocidad

    NASA Astrophysics Data System (ADS)

    Morras, R.; Bajaja, E.; Arnal, E. M.; Pöppel, W. G. L.

    Los resultados del relevamiento de HI del Hemisferio Austral fueron reprocesados con el fin de incrementar su sensibilidad. Así, se utilizó esta nueva base de datos con el fin de obtener un nuevo relevamiento de Nubes de Alta Velocidad en el cielo austral. El ruido r.m.s. alcanzado es de 0.015-0.020 K, con una resolución espectral de 8 km/seg. El cubrimiento espacial del relevamiento mejora en un factor 16 al realizado por Bajaja et al (1985).

  20. Observaciones del CH interestelar y el continuo en 3,3 GHz

    NASA Astrophysics Data System (ADS)

    Olano, C. A.; Combi, J. A.; Pöppel, W.; Benaglia, P.; Sanz, A. J.; Bava, J. A.

    Se informa sobre el proyecto que se lleva a cabo en el IAR con el propósito de observar las líneas hiperfinas del estado fundamental del CH y el continuo en la banda de 3,3 GHz. El nuevo receptor construído en nuestro laboratorio para tal fin se instaló sobre uno de los radiotelescopios, funcionando conjuntamente con los sistemas de procesamiento actuales del IAR. Los resultados de las primeras observaciones, realizadas tanto en las líneas espectrales como en el continuo sobre fuentes conocidas, fueron satisfactorios.

  1. General nonextremal rotating charged Gödel black holes in minimal five-dimensional gauged supergravity.

    PubMed

    Wu, Shuang-Qing

    2008-03-28

    I present the general exact solutions for nonextremal rotating charged black holes in the Gödel universe of five-dimensional minimal supergravity theory. They are uniquely characterized by four nontrivial parameters: namely, the mass m, the charge q, the Kerr equal rotation parameter a, and the Gödel parameter j. I calculate the conserved energy, angular momenta, and charge for the solutions and show that they completely satisfy the first law of black hole thermodynamics. I also study the symmetry and separability of the Hamilton-Jacobi and the massive Klein-Gordon equations in these Einstein-Maxwell-Chern-Simons-Gödel black hole backgrounds. PMID:18517852

  2. General Nonextremal Rotating Charged Gödel Black Holes in Minimal Five-Dimensional Gauged Supergravity

    NASA Astrophysics Data System (ADS)

    Wu, Shuang-Qing

    2008-03-01

    I present the general exact solutions for nonextremal rotating charged black holes in the Gödel universe of five-dimensional minimal supergravity theory. They are uniquely characterized by four nontrivial parameters: namely, the mass m, the charge q, the Kerr equal rotation parameter a, and the Gödel parameter j. I calculate the conserved energy, angular momenta, and charge for the solutions and show that they completely satisfy the first law of black hole thermodynamics. I also study the symmetry and separability of the Hamilton-Jacobi and the massive Klein-Gordon equations in these Einstein-Maxwell-Chern-Simons-Gödel black hole backgrounds.

  3. HAER DEL,3MILF.V,2 (sheet 1 of 4) Mispillion Lighthouse, South ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER DEL,3-MILF.V,2- (sheet 1 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

  4. HAER DEL,3MILF.V,2 (sheet 2 of 4) Mispillion Lighthouse, South ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER DEL,3-MILF.V,2- (sheet 2 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

  5. HAER DEL,3MILF.V,2 (sheet 3 of 4) Mispillion Lighthouse, South ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER DEL,3-MILF.V,2- (sheet 3 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

  6. HAER DEL,3MILF.V,2 (sheet 4 of 4) Mispillion Lighthouse, South ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER DEL,3-MILF.V,2- (sheet 4 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

  7. New genera of Lachesillidae (Psocodea: 'Psocoptera': Eolachesillinae: Graphocaeciliini) from Valle del Cauca, Colombia.

    PubMed

    García Aldrete, Alfonso N; González Obando, Ranulfo; Carrejo, Nancy S

    2013-01-01

    Two new related Colombian genera of Lachesillidae, including three new species, from the Department of Valle del Cauca, are here described and illustrated. They belong in the tribe Graphocaeciliini (Eolachesillinae). The new genera differ from the other genera in the tribe lacking ocelli, by characters of the male clunium, phallosome, endophallus, paraprocts, and female subgenital plate, gonapophyses and IX sternum. The types are deposited in the Entomological Museum of the Universidad del Valle (MUSENUV), in Santiago de Cali, Colombia.

  8. Defining the defect in F508 del CFTR: a soluble problem?

    PubMed

    Deber, Charles M; Cheung, Joanne C; Rath, Arianna

    2008-01-01

    Previously reported crystal structures of CFTR F508 del-NBD1 were determined in the presence of solubilizing mutations. In this issue of Chemistry & Biology, Pissarra et al. (2008) show that partial rescue of the trafficking and gating defects of full-length CFTR occurs in vivo upon recapitulation of the solubilizing F494N/Q637R or F428S/F494N/Q637R substitutions in cis with F508 del. PMID:18215767

  9. Large amplitude super-soft X-ray intensity variations and a 54 sec QPO in Nova Del 2013 (V339 Del)

    NASA Astrophysics Data System (ADS)

    Beardmore, A. P.; Osborne, J. P.; Page, K. L.

    2013-11-01

    In ATEL #5505 we reported the rise of the super-soft X-ray source in Nova Del 2013 (V339 Del) seen by the Swift XRT. Since the last observation reported there, at 1.5 c/s on day 70.8 after outburst, the soft X-ray count rate has risen to a peak count rate of ~100 c/s on day 87.9 (10 Nov). All count rates are from grade 0 events only. The rising count rate was interspersed by a few large dips, one of which reached down to <1% of the count rate one day earlier.

  10. Unravelling druggable signalling networks that control F508del-CFTR proteostasis

    PubMed Central

    Hegde, Ramanath Narayana; Parashuraman, Seetharaman; Capuani, Fabrizio; Carissimo, Annamaria; Carrella, Diego; Belcastro, Vincenzo; Subramanian, Advait; Bounti, Laura; Persico, Maria; Carlile, Graeme; Galietta, Luis; Thomas, David Y; Di Bernardo, Diego; Luini, Alberto

    2015-01-01

    Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostatic regulation are well studied, while the question whether ‘classical’ signalling pathways and phosphorylation cascades might control proteostasis remains barely explored. Here, we have unravelled signalling cascades acting selectively on the F508del-CFTR folding-trafficking defects by analysing the mechanisms of action of F508del-CFTR proteostasis regulator drugs through an approach based on transcriptional profiling followed by deconvolution of their gene signatures. Targeting multiple components of these signalling pathways resulted in potent and specific correction of F508del-CFTR proteostasis and in synergy with pharmacochaperones. These results provide new insights into the physiology of cellular proteostasis and a rational basis for developing effective pharmacological correctors of the F508del-CFTR defect. DOI: http://dx.doi.org/10.7554/eLife.10365.001 PMID:26701908

  11. Unravelling druggable signalling networks that control F508del-CFTR proteostasis.

    PubMed

    Hegde, Ramanath Narayana; Parashuraman, Seetharaman; Iorio, Francesco; Ciciriello, Fabiana; Capuani, Fabrizio; Carissimo, Annamaria; Carrella, Diego; Belcastro, Vincenzo; Subramanian, Advait; Bounti, Laura; Persico, Maria; Carlile, Graeme; Galietta, Luis; Thomas, David Y; Di Bernardo, Diego; Luini, Alberto

    2015-01-01

    Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostatic regulation are well studied, while the question whether 'classical' signalling pathways and phosphorylation cascades might control proteostasis remains barely explored. Here, we have unravelled signalling cascades acting selectively on the F508del-CFTR folding-trafficking defects by analysing the mechanisms of action of F508del-CFTR proteostasis regulator drugs through an approach based on transcriptional profiling followed by deconvolution of their gene signatures. Targeting multiple components of these signalling pathways resulted in potent and specific correction of F508del-CFTR proteostasis and in synergy with pharmacochaperones. These results provide new insights into the physiology of cellular proteostasis and a rational basis for developing effective pharmacological correctors of the F508del-CFTR defect. PMID:26701908

  12. Unravelling druggable signalling networks that control F508del-CFTR proteostasis.

    PubMed

    Hegde, Ramanath Narayana; Parashuraman, Seetharaman; Iorio, Francesco; Ciciriello, Fabiana; Capuani, Fabrizio; Carissimo, Annamaria; Carrella, Diego; Belcastro, Vincenzo; Subramanian, Advait; Bounti, Laura; Persico, Maria; Carlile, Graeme; Galietta, Luis; Thomas, David Y; Di Bernardo, Diego; Luini, Alberto

    2015-12-23

    Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostatic regulation are well studied, while the question whether 'classical' signalling pathways and phosphorylation cascades might control proteostasis remains barely explored. Here, we have unravelled signalling cascades acting selectively on the F508del-CFTR folding-trafficking defects by analysing the mechanisms of action of F508del-CFTR proteostasis regulator drugs through an approach based on transcriptional profiling followed by deconvolution of their gene signatures. Targeting multiple components of these signalling pathways resulted in potent and specific correction of F508del-CFTR proteostasis and in synergy with pharmacochaperones. These results provide new insights into the physiology of cellular proteostasis and a rational basis for developing effective pharmacological correctors of the F508del-CFTR defect.

  13. MALARIA VECTORS IN SAN JOSÉDEL GUAVIARE, ORINOQUIA, COLOMBIA

    PubMed Central

    JIMÉNEZ, IRENE P.; CONN, JAN E.; BROCHERO, HELENA

    2015-01-01

    This study was conducted to determine Anopheles species composition and their natural infectivity by human Plasmodium in 2 localities with the highest malaria transmission in San Jose del Guaviare, Guaviare, Colombia. A total of 1,009 Anopheles mosquitoes were collected using human landing catches during 8 months in 2010. Anopheles darlingi was the most abundant (83.2%) followed by An. albitarsis s.l. (8.6%), Anopheles braziliensis (3.8%), An. oswaldoi s.l. (1%), and An. rangeli (0.3%). Anopheles darlingi showed the highest human biting rate, and it was found naturally infected with Plasmodium vivax VK210 (0.119%) using enzyme-linked immunosorbent assays. All species were collected biting both indoors and outdoors. Anopheles darlingi showed biting activity overnight with an indoor peak between 1200–0100 h. Therefore, we recommend that malaria prevention strategies focus on 1) insecticide-treated nets to reduce human–vector contact when people are most exposed and unprotected; 2) accurate diagnoses; 3) adequate treatment for patients; 4) more timely epidemiological notification; and 5) improved entomological surveillance. PMID:25102591

  14. Seismicity following the 1985 eruption of Nevado del Ruiz, Colombia

    USGS Publications Warehouse

    Zollweg, J.E.

    1990-01-01

    Over 200 of the best-recorded earthquakes occurring near Nevado del Ruiz, Colombia, between December 1985 and May 1986 are examined for spatial patterns, information on local stress orientations, and evidence for seismogenic structures that may be related to magma-transport processes. These earthquakes occurred following the devastating eruption of November 13, 1985. Earthquake activity that is probably related to the volcanic system occurs over a large area, of the order of 50 km2. A pattern of earthquakes beneath the southern half of Ruiz may be the expression of a conduit system, but evidence is inconclusive due to low spatial resolution of most hypocenters. Epicenter and first-motion plots suggest most earthquakes occur on small faults of varying orientation. Most seismicity during this time period was unrelated to mapped faults, including some with Holocene offsets, except for the Villamaria Fault near Ruiz's northeast sector. Composite focal mechanisms show a variation of nearly 90?? in the strike of T-axes and indicate Ruiz is in a zone of local extension. ?? 1990.

  15. ``Campo del Cielo'' Meteorites: Astronomical Heritage and Cultural Colonialism

    NASA Astrophysics Data System (ADS)

    López, Alejandro Martín; Altman, Agustina

    2012-09-01

    In the province of Chaco, Argentina, there is a very unique dispersion of metallic meteorites called ``Campo del Cielo''. One of the meteoric fragments of this dispersion, the meteorite called ``El Chaco'', consisting of 37 tons, is the second heaviest in the world. These meteorites are of great importance to the worldview of the Moqoit, aboriginal people that inhabit this region. For the local Creole population the meteorites are also relevant, that's why they have being cited in numerous documents and reports since the colonial period. During the first months of 2012, two Argentine artists and the Artistic Director of the German contemporary art exhibition called dOCUMENTA (13) tried to move ``El Chaco'' meteorite to Germany in order to exhibit it as an artistic object. Due to the fact that moving the meteorite could have a negative impact according to the Moqoit cosmology and that they were not able to participate in the decision they begun a manifestation against the movement of El Chaco. The opposition made by aboriginal communities and experts in cultural astronomy was able to stop the transfer. The whole process and its impact on the local community have promoted a deep discussion about art, science and cultural colonialism. In this paper we aim to address this debate and its consequences. This will allow us to think about contemporary forms of colonialism that are hidden in many scientific and artistic projects. Furthermore, we aim to debate about the most effective ways of protecting astronomical heritage in the Third World.

  16. El uso de la neuromodulación para el tratamiento del temblor

    PubMed Central

    Bendersky, Damián; Ajler, Pablo; Yampolsky, Claudio

    2014-01-01

    Introducción: El temblor puede ser un desorden incapacitante y el tratamiento de primera línea para estos pacientes es farmacológico. Sin embargo, este tratamiento puede llevar a una reducción satisfactoria del temblor en sólo el 50% de los pacientes con temblor esencial. La talamotomía era el tratamiento de elección para el temblor refractario al tratamiento médico hasta que comenzó a utilizarse la estimulación cerebral profunda (ECP) del núcleo ventral intermedio (Vim) del tálamo. En la actualidad, raramente se realiza la talamotomía. Métodos: Este artículo es una revisión no sistemática de las indicaciones, resultados, parámetros de programación y técnica quirúrgica de la ECP del Vim para el tratamiento del temblor. Resultados: Aunque los resultados clínicos son similares usando la talamotomía o la ECP del Vim, la primera causa más efectos adversos que la última. Además, la ECP puede ser usada bilateralmente, mientras que la talamotomía tiene un alto riesgo de causar disartria cuando se realiza de ambos lados. La ECP del Vim logró una adecuada mejoría del temblor en varias series de pacientes con temblor causado por temblor esencial, enfermedad de Parkinson o esclerosis múltiple. Además del Vim, hay otros blancos que están siendo usados por varios autores, tales como la zona incerta y las radiaciones prelemniscales. Conclusión: La ECP del Vim es un tratamiento útil para el temblor incapacitante refractario al tratamiento médico. Es esencial realizar una precisa selección de pacientes, así como utilizar una técnica quirúrgica correcta. Aún se desconoce el mejor blanco estereotáctico para el temblor, aunque el Vim es el más usado. PMID:25165613

  17. [Guideline for the assessment of clinical research proposals. Comisión Nacional de Investigación Científica del Instituto Mexicano del Seguro Social].

    PubMed

    Mejía-Aranguré, Juan Manuel; Grijalva-Otero, Israel; Majluf-Cruz, Abraham; Cruz-López, Miguel; Núñez-Enríquez, Juan Carlos; Salamanca-Gómez, Fabio Abdiel

    2013-01-01

    Antecedentes: la investigación médica es una herramienta fundamental para lograr el avance de la ciencia al mejorar las acciones encaminadas a proteger, promover y restaurar la salud del individuo y de la sociedad en general. Las tres características imprescindibles para que un protocolo de investigación sea autorizado son: relevancia científica, calidad técnica y el cumplimiento de los aspectos éticos. Material y métodos: estudio retrospectivo efectuado con base en la búsqueda específica en Pubmed, Medline, Ovid y Google Scholar con los términos: peer review, research proposals, review and protocols and reviewers. Debido a que no se identificó ningún artículo que refiriera específicamente los criterios para evaluar protocolos de investigación clínica, se hizo un consenso entre los vocales de la Comisión Nacional de Investigación Científica del Instituto Mexicano del Seguro Social, que está integrada por investigadores titulares de la institución, todos pertenecientes al Sistema Nacional de Investigadores. Se discutieron los criterios que debieran componer una revisión adecuada y cuáles debieran ser los rubros que deben incluirse en el análisis. Resultados: se integraron los criterios específicos que le permitirán al revisor de un protocolo de investigación realizar una crítica con bases metodológicas aceptadas por un consenso de investigadores. Conclusiones: un revisor debe ser considerado como un promotor del avance del conocimiento científico que, mediante sus comentarios y su dictamen, permite que los investigadores incrementen la calidad de sus protocolos de investigación.

  18. Resistivity structure of the Del Mar methane seep.

    NASA Astrophysics Data System (ADS)

    Kannberg, P. K.; Constable, S.

    2015-12-01

    In March of 2015 we mapped the resistivity structure of the Del Mar methane seep in the inner California borderlands using a deep towed electromagnetic (EM) source and receiver array. Located in the San Diego trough at a depth of 1km, the seep site is on the flank of a mound associated with a transpressive step in the San Diego trough fault. The seep site has previously been associated with seafloor pockmarks, acoustic wipeouts, chemosynthetic communities, and active methane bubble venting. Controlled source electromagnetic (CSEM) surveys are performed by deep-towing an EM source that is transmitting a known signal; this signal is detected by towed receivers. This transmitted signal is altered by the electrical properties of the surrounding environment. Compared to seismic methods, EM methods are largely insensitive to free gas, making it an especially useful tool for detecting electrically resistive methane hydrate in areas of active gas venting. We used a 50m dipole transmitting 100A, with 3-axis electric field receivers spaced at 130m, 230m, 330m, and 430m behind the transmitter dipole center. The receiver data are inverted using MARE2DEM, a finite element 2D inversion routine. The inversion results show the background resistivity of the trough sediments to be about 1-2 ohmm, and are largely featureless outside of the seep site. However at the seep site we see a decanter-shaped 100 ohmm resistor whose base is 100m below the seafloor, and 1km wide at its widest. This feature narrows at the top to form a pipe structure about 200m wide that extends to the seafloor. These resistive structures are interpreted to be methane hydrate resulting from methane rich fluid flow along faults associated with the transpressional system that brackets the seep site.

  19. Predicting Nonspecific Ion Binding Using DelPhi

    PubMed Central

    Petukh, Marharyta; Zhenirovskyy, Maxim; Li, Chuan; Li, Lin; Wang, Lin; Alexov, Emil

    2012-01-01

    Ions are an important component of the cell and affect the corresponding biological macromolecules either via direct binding or as a screening ion cloud. Although some ion binding is highly specific and frequently associated with the function of the macromolecule, other ions bind to the protein surface nonspecifically, presumably because the electrostatic attraction is strong enough to immobilize them. Here, we test such a scenario and demonstrate that experimentally identified surface-bound ions are located at a potential that facilitates binding, which indicates that the major driving force is the electrostatics. Without taking into consideration geometrical factors and structural fluctuations, we show that ions tend to be bound onto the protein surface at positions with strong potential but with polarity opposite to that of the ion. This observation is used to develop a method that uses a DelPhi-calculated potential map in conjunction with an in-house-developed clustering algorithm to predict nonspecific ion-binding sites. Although this approach distinguishes only the polarity of the ions, and not their chemical nature, it can predict nonspecific binding of positively or negatively charged ions with acceptable accuracy. One can use the predictions in the Poisson-Boltzmann approach by placing explicit ions in the predicted positions, which in turn will reduce the magnitude of the local potential and extend the limits of the Poisson-Boltzmann equation. In addition, one can use this approach to place the desired number of ions before conducting molecular-dynamics simulations to neutralize the net charge of the protein, because it was shown to perform better than standard screened Coulomb canned routines, or to predict ion-binding sites in proteins. This latter is especially true for proteins that are involved in ion transport, because such ions are loosely bound and very difficult to detect experimentally. PMID:22735539

  20. Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades

    NASA Astrophysics Data System (ADS)

    Cirigliano, D.; Vial, J. C.; Rovira, M.

    A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

  1. Apparent Motion of the Sun, Shadows of Objects and Measurement of Time in the View of Seventh Grade Students of Middle School. (Breton Title: Movimento Aparente do Sol, Sombras dos Objetos e Medição do Tempo na Visão de Alunos do Sétimo Ano do Ensino Fundamental.) Movimiento Aparente del Sol, Sombras de los Objetos y Medición del Tiempo en la Visión de Estudiantes del Séptimo Grado del Ciclo Pirmario

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel

    2013-07-01

    analemático, conduzida por um monitor. Uma proporção significativa de estudantes desconhecia inicialmente a maioria dos fenômenos tratados. A intervenção realizada colaborou para uma parte dos alunos assimilar novos conceitos, propiciando o contato com novos fenômenos e, em menor grau, a elaboração de explicações a respeito destes, indicando um potencial educativo dessa ação. Porém, a contribuição para o entendimento de algumas das ideias exploradas foi pequena, apontando para a necessidade de se fazer observações, estudos e discussões complementares. El movimiento aparente del Sol en la esfera celeste y el comportamiento de las sombras de los objetos a lo largo del tiempo son fenómenos observables en la vida cotidiana. Sin embargo, los estudiantes a menudo no tienen una adecuada comprensión de dichos problemas, e incluso pueden mostrar conceptos erróneos acerca de ellos. Por lo tanto, se realizó una investigación a fin de conocer las nociones de los estudiantes acerca de estas cuestiones y evaluar la contribución a su comprensión proporcionada por una actividad realizada con un reloj de Sol interactivo, en un entorno informal de aprendizaje. Se investigaron las ideas de 43 estudiantes del séptimo grado del ciclo primario mediante la aplicación de un test con preguntas abiertas antes y después de una actividad con un reloj de Sol analemático, dirigida por un monitor. Una proporción significativa de los estudiantes inicialmente desconocía la mayoría de los fenómenos tratados. La intervención realizada contribuyó para que los estudiantes asimilasen nuevos conceptos, proporcionando el contacto con nuevos fenómenos y, en menor medida, desarrollasen explicaciones acerca de estos, lo que indica un potencial educativo de esta acción. Sin embargo, la contribución a la comprensión de algunas de las ideas exploradas fue pequeña, lo que apunta a la necesidad de hacer observaciones, estudios y debates adicionales.

  2. La implantacion del enfoque constructivista en el aula de ciencia: Estudio de caso multiple

    NASA Astrophysics Data System (ADS)

    Arroyo Betancourt, Luz I.

    Esta investigacion estudia la implantacion del enfoque constructivista en tres aulas de ciencia del contexto puertorriqueno. Se auscultaron las practicas educativas que utilizan maestras consideradas constructivistas y la correspondencia de sus practicas educativas con los elementos esenciales de la didactica que proponen los teoricos de los planteamientos constructivistas. Se ausculto, ademas, a que vision del enfoque constructivista responden las expresiones de las maestras acerca de su practica educativa y como compara con su quehacer, a la luz de los elementos esenciales de las visiones constructivistas piagetiana, social y radical. Se utilizo el diseno de estudio descriptivo de caso multiple. El estudio se baso en entrevistas a profundidad, revision de documentos y observacion no participativa a la sala de clases. El contexto fueron tres escuelas publicas de la Region Educativa de San Juan, una elemental, una intermedia y una superior. Los resultados confirmaron que la transicion hacia el enfoque constructivista es un proceso que toma tiempo, dedicacion y la participacion en adiestramientos y readiestramientos acerca del nuevo enfoque. Las maestras coinciden en la mayoria de las practicas educativas que utilizan para implantar el enfoque constructivista de ensenanza y difieren en algunas debido, probablemente, a que han tenido que adaptarlas a los correspondientes niveles de ensenanza: elemental, intermedio y superior. Dos de las maestras planifican por conceptos generadores, mientras que una de ellas planifica siguiendo la guia que recibe del Departamento de Educacion. Difieren ademas, en el enfasis que confieren al inquirir cientifico. Con relacion a la correspondencia entre la vision manifestada por las maestras a la luz de las visiones piagetiana, social y radical, aparentemente, las preguntas del protocolo de entrevistas no lograron evocar la informacion con suficiente profundidad, por lo que la investigadora tuvo que inferir las visiones de las

  3. Detecting a hierarchical genetic population structure via Multi-InDel markers on the X chromosome.

    PubMed

    Fan, Guang Yao; Ye, Yi; Hou, Yi Ping

    2016-01-01

    Detecting population structure and estimating individual biogeographical ancestry are very important in population genetics studies, biomedical research and forensics. Single-nucleotide polymorphism (SNP) has long been considered to be a primary ancestry-informative marker (AIM), but it is constrained by complex and time-consuming genotyping protocols. Following up on our previous study, we propose that a multi-insertion-deletion polymorphism (Multi-InDel) with multiple haplotypes can be useful in ancestry inference and hierarchical genetic population structures. A validation study for the X chromosome Multi-InDel marker (X-Multi-InDel) as a novel AIM was conducted. Genetic polymorphisms and genetic distances among three Chinese populations and 14 worldwide populations obtained from the 1000 Genomes database were analyzed. A Bayesian clustering method (STRUCTURE) was used to discern the continental origins of Europe, East Asia, and Africa. A minimal panel of ten X-Multi-InDels was verified to be sufficient to distinguish human ancestries from three major continental regions with nearly the same efficiency of the earlier panel with 21 insertion-deletion AIMs. Along with the development of more X-Multi-InDels, an approach using this novel marker has the potential for broad applicability as a cost-effective tool toward more accurate determinations of individual biogeographical ancestry and population stratification. PMID:27535707

  4. The RGD finger of Del-1 is a unique structural feature critical for integrin binding

    SciTech Connect

    Schürpf, Thomas; Chen, Qiang; Liu, Jin-huan; Wang, Rui; Springer, Timothy A.; Wang, Jia-huai

    2012-11-13

    Developmental endothelial cell locus-1 (Del-1) glycoprotein is secreted by endothelial cells and a subset of macrophages. Del-1 plays a regulatory role in vascular remodeling and functions in innate immunity through interaction with integrin {alpha}{sub V}{beta}{sub 3}. Del-1 contains 3 epidermal growth factor (EGF)-like repeats and 2 discoidin-like domains. An Arg-Gly-Asp (RGD) motif in the second EGF domain (EGF2) mediates adhesion by endothelial cells and phagocytes. We report the crystal structure of its 3 EGF domains. The RGD motif of EGF2 forms a type II' {beta} turn at the tip of a long protruding loop, dubbed the RGD finger. Whereas EGF2 and EGF3 constitute a rigid rod via an interdomain calcium ion binding site, the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1. Two unique O-linked glycans and 1 N-linked glycan locate to the opposite side of EGF2 from the RGD motif. These structural features favor integrin binding of the RGD finger. Mutagenesis data confirm the importance of having the RGD motif at the tip of the RGD finger. A database search for EGF domain sequences shows that this RGD finger is likely an evolutionary insertion and unique to the EGF domain of Del-1 and its homologue milk fat globule-EGF 8. The RGD finger of Del-1 is a unique structural feature critical for integrin binding.

  5. Detecting a hierarchical genetic population structure via Multi-InDel markers on the X chromosome

    PubMed Central

    Fan, Guang Yao; Ye, Yi; Hou, Yi Ping

    2016-01-01

    Detecting population structure and estimating individual biogeographical ancestry are very important in population genetics studies, biomedical research and forensics. Single-nucleotide polymorphism (SNP) has long been considered to be a primary ancestry-informative marker (AIM), but it is constrained by complex and time-consuming genotyping protocols. Following up on our previous study, we propose that a multi-insertion-deletion polymorphism (Multi-InDel) with multiple haplotypes can be useful in ancestry inference and hierarchical genetic population structures. A validation study for the X chromosome Multi-InDel marker (X-Multi-InDel) as a novel AIM was conducted. Genetic polymorphisms and genetic distances among three Chinese populations and 14 worldwide populations obtained from the 1000 Genomes database were analyzed. A Bayesian clustering method (STRUCTURE) was used to discern the continental origins of Europe, East Asia, and Africa. A minimal panel of ten X-Multi-InDels was verified to be sufficient to distinguish human ancestries from three major continental regions with nearly the same efficiency of the earlier panel with 21 insertion-deletion AIMs. Along with the development of more X-Multi-InDels, an approach using this novel marker has the potential for broad applicability as a cost-effective tool toward more accurate determinations of individual biogeographical ancestry and population stratification. PMID:27535707

  6. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis

    PubMed Central

    Wang, Zhen; Tran, Misha C.; Bhatia, Namrata J.; Hsing, Alexander W.; Chen, Carol; LaRussa, Marie F.; Fattakhov, Ernst; Rashidi, Vania; Jang, Kyu Yun; Choo, Kevin J.; Nie, Xingju; Mathy, Jonathan A.; Longaker, Michael T.; Dauskardt, Reinhold H.; Helms, Jill A.; Yang, George P.

    2016-01-01

    Objective We identified significant expression of the matricellular protein, DEL1, in hypertrophic and mature cartilage during development. We hypothesized that this tissue-specific expression indicated a biological role for DEL1 in cartilage biology. Methods Del1 KO and WT mice had cartilage thickness evaluated by histomorphometry. Additional mice underwent medial meniscectomy to induce osteoarthritis, and were assayed at 1 week for apoptosis by TUNEL staining and at 8 weeks for histology and OA scoring. In vitro proliferation and apoptosis assays were performed on primary chondrocytes. Results Deletion of the Del1 gene led to decreased amounts of cartilage in the ears and knee joints in mice with otherwise normal skeletal morphology. Destabilization of the knee led to more severe OA compared to controls. In vitro, DEL1 blocked apoptosis in chondrocytes. Conclusion Osteoarthritis is among the most prevalent diseases worldwide and increasing in incidence as our population ages. Initiation begins with an injury resulting in the release of inflammatory mediators. Excessive production of inflammatory mediators results in apoptosis of chondrocytes. Because of the limited ability of chondrocytes to regenerate, articular cartilage deteriorates leading to the clinical symptoms including severe pain and decreased mobility. No treatments effectively block the progression of OA. We propose that direct modulation of chondrocyte apoptosis is a key variable in the etiology of OA, and therapies aimed at preventing this important step represent a new class of regenerative medicine targets. PMID:27505251

  7. High mountain soils and periglacial features at the Torres del Paine, National Park Torres del Paine, Chile.

    NASA Astrophysics Data System (ADS)

    Senra, Eduardo; Schaefer, Carlos; Simas, Felipe; Gjorup, Davi

    2015-04-01

    The Torres del Paine National Park (TPNP) is located on the southern limit of the Andean Southern Ice Field, part of the Magallanes and Antartica Chilena region, in the province of Ultima Esperanza. The TPNP has a very heterogeneous climate due to orographic influence and wet air masses from the Pacific. The geology is basically Cretaceous metasedimentary rocks and Miocene granitic plutons and batholiths. We studied the main soils and geoenvironments of Mt Ferrier mountain and its surroundings, based on soils , landforms and vegetation aspects. The geoenvironmental stratification was based on the combined variation and integration of pedo-litho-geomorphological features with the vegetation. WE used detailed geological maps, a DEM and slope maps and WorlView II satellite images. Fifteen soils profiles were sampled and classified according to Soil Taxonomy (2010) at all genovironments, ranging from 50 m a.s.l to the at high plateau just below the permanent snowline, under periglacial conditions (~1004m asl). Three soil temperature and moisture monitoring sites were set, allowing for 24 consecutive months (2011 to 2013). Seven geoenvironments were identified with distinct soil and landform characteristics, all with a similar geological substrate. The landform and vegetation have a strong connection with the landscape dynamic, controlling erosional and depositional processes, resulting from glacier advances and retreats in the Late Quaternary. Wind blown materials is widespread, in the form of loess material, accumulating in the higher parts of the landscape. On the other hand, accumulation of organic matter in the water-saturated depressions is common in all altitudes. Generally the soils are acidic and dystrophic, with little exceptions. The following geoenvironments were identified: Periglacial Tundra, Loess slopes, Talus and scarpmentd, Fluvio-glacial terraces, Fluvio-lacustrine plains, Moraines and Paleodunes. The regional pedology show the occurrence of five soil

  8. Mejoras en el apuntado del telescopio de 2,15 mts de CASLEO

    NASA Astrophysics Data System (ADS)

    Aballay, J. L.; Casagrande, A. R.; Pereyra, P. F.; Marún, A. H.

    Con el objeto de optimizar el funcionamiento del telescopio de 2,15 mts. de CASLEO, se están eliminando los motores de calar, de guía y mecánica asociada. Para ésto, se están diseñando dos electrónicas que gobernarán, solamente, el motor de slew y el de tracking. Con el control del motor de slew se realizarán las funciones de slew y calar, controlando desde una PC la placa que maneja las rampas de velocidad. De este modo, el movimiento será programado y por lo tanto, más suave y preciso. Con el control del motor de tracking, a través de un generador de frecuencias programable desde una PC, se proveerá los movimientos necesarios para el tracking y guía.

  9. Biotic association and palaeoenvironmental reconstruction of the "Loma del Pterodaustro" fossil site (Early Cretaceous, Argentina)

    USGS Publications Warehouse

    Chiappe, L.; Rivarola, D.; Cione, A.; Fregenal-Martinez, M.; Sozzi, H.; Buatois, L.; Gallego, O.; Laza, J.; Romero, E.; Lopez-Arbarello, A.; Buscalioni, A.; Marsicano, C.; Adamonis, S.; Ortega, F.; McGehee, S.; Di, Iorio O.

    1998-01-01

    A sedimentological analysis of the basal section of the Early Cretaceous, lacustrine Lagarcito Formation at "Loma del Pterodaustro" (San Luis, Argentina) and a summary of its biological components are presented. Three sedimentological facies can be recognized in the basal sequence of the Lagarcito Formation. Fossil remains are particularly abundant in laminated claystones of a facies interpreted as deposits formed in offshore areas of the lake. The preservation of delicate structures allows recognition of these deposits as a Konservat Lagersta??tte. Up to now, rocks at "Loma del Pterodaustro" have yielded plants, conchostracans, semionotid and pleuropholid fishes, pterodactyloid pterosaurs, and a variety of invertebrate traces. The chronology of the Lagarcito Formation is discussed and it is concluded that this unit is of Albian age. The palaeoenvironment of deposition of the basal sequence of the Lagarcito Formation at "Loma del Pterodaustro" is interpreted as a perennial, shallow lake developed within an alluvial plain, under semiarid climatic conditions.

  10. Ectopsocidae (Psocodea: 'Psocoptera') from Valle del Cauca and NNP Gorgona, Colombia.

    PubMed

    Manchola, Oscar Fernando Saenz; Obando, Ranulfo González; Aldrete, Alfonso N García

    2014-04-14

    The results of a survey of the psocid family Ectopsocidae in Valle del Cauca and NNP Gorgona, are here presented. Fifteen species were identified, in the genera Ectopsocus (14 species), and Ectopsocopsis (one species); four of the Ectopsocus species are new to science and are here described and illustrated. The male of E. thorntoni García Aldrete is here described. Records of Ectopsocopsis cryptomeriae (Enderlein), Ectopsocus briggsi McLachlan, E. californicus Banks, E. columbianus Badonnel, E. maindroni Badonnel, E. meridionalis Ribaga, E. pilosus Badonnel, E. richardsi Pearman, E. titschacki Jentsch, and E. vilhenai Badonnel, are provided. Ten species were found only in Valle del Cauca, two species were found only in the NNP Gorgona, and three species were found at both sites. The specimens studied are deposited in the Entomological Museum, Universidad del Valle, Santiago de Cali, Colombia (MUSENUV).

  11. La relatività debole. La fisica dello spazio e del tempo senza paradossi

    NASA Astrophysics Data System (ADS)

    Selleri, Franco

    2011-06-01

    Secondo Einstein e Poincaré la simultaneità di eventi che hanno luogo in punti diversi dello spazio può essere definita solo per convenzione. Dal punto di vista matematico si dimostra, quindi, che due diverse definizioni di simultaneità corrispondono a due diversi valori del coefficiente e1 della variabile spaziale x presente nelle trasformazioni di Lorentz. A partire da premesse normalmente accettate otterremo diverse dimostrazioni della necessità di reintrodurre il concetto di simultaneità assoluta. Le conseguenze cosmologiche della nuova struttura dello spazio e del tempo andranno contro la cosmologia del Big Bang. Inoltre, dopo questi risultati, il relativismo sopravviverà in una forma meno aspra ("relatività debole") perché risulter privo di quel campionario di paradossi portato dalla teoria della Relatività Speciale.

  12. Integrated global background monitoring network. Preliminary results from Torres del Paine and Olympic National Parks

    SciTech Connect

    Wiersma, G.B.; Kohler, A.; Boelcke, C.; Baker, G.; Harmon, M.; Weber, C.; Gonzales, J.

    1985-10-01

    During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrated global backgound monitoring network. Eventually, the plan is to establish a world-wide system of such sites. We collected and analyzed samples of the soil, water, air, and two species of plants (moss and lichen). We also collected and analyzed samples of the forest litter. We compared the samples of soil and vegetation against reference samples. We also compared samples of soil, vegetation, and of organic material from Torres del Paine against similar samples from Olympic and Sequoia-Kings Canyon National Parks in the United States. Although the data is preliminary, it is in agreement with out initial hypothesis that Torres del Paine and Olympic National Parks are not a polluted sites.

  13. CASE REPORT: Phenotypic presentation of the Ser63Del MPZ mutation

    PubMed Central

    Miller, Lindsey J.; Patzko, Agnes; Lewis, Richard A.; Shy, Michael E.

    2013-01-01

    Mutations in MPZ cause CMT1B, the second most frequent cause of CMT1. Elegant studies with Ser63del mice suggest that Ser63del MPZ is retained in the ER where it activates the unfolded protein response (UPR) that contributes to the neuropathy. Clinical information about patients with this mutation is limited. We present clinical and electrophysiological data on a large multigenerational family with CMT1B caused by Ser63del MPZ. The patients have a classical CMT1 phenotype that is much less severe than that of patients with Arg98Cys MPZ that also activates the UPR. These results suggest that clinical presentation along cannot predict which MPZ mutations will be retained in the ER and activate the UPR. PMID:22734905

  14. L'eliosismologia: onde sismiche per studiare l'interno del Sole

    NASA Astrophysics Data System (ADS)

    Di Mauro, M. P.

    2014-12-01

    Negli ultimi cinquanta anni siamo stati testimoni di una straordinaria rivoluzione della conoscenza e comprensione della nostra stella grazie alla nascita dell'Eliosismologia, lo studio delle oscillazioni solari. Analogamente a ciò che accade nella Terra durante i terremoti, anche l'interno del Sole è pervaso continuamente da onde sismiche che provocano piccole oscillazioni, ovvero deformazioni della fotosfera. Le oscillazioni sono la manifestazione di diversi processi che avvengono all'interno della struttura del Sole e le frequenze sismiche dei modi osservati e misurati sulla superficie sono legate direttamente ai parametri fisici degli strati interni attraversati dalle onde sismiche. Lo studio delle oscillazioni rappresenta, quindi, l'unico metodo diretto per studiare la struttura e la dinamica interna del Sole. In questo articolo verranno illustrate le caratteristiche generali delle oscillazioni solari e verranno presentati i risultati importanti e i progressi notevoli raggiunti grazie all'Eliosismologia.

  15. Trichomycetes living in the guts of aquatic insects of Misiones and Tierra del Fuego, Argentina.

    PubMed

    López Lastra, Claudia C; Scorsetti, Ana C; Marti, Gerardo A; Coscarón, Sixto

    2005-01-01

    Fourteen species of Trichomycetes living in the guts of aquatic insects are reported from two provinces of Argentina, Misiones and Tierra del Fuego. Twelve of the species belong to the Harpellales and two are Amoebidiales. Five harpellid species are reported from Misiones in the extreme northeast of the country (Genistellospora homothallica, Harpella tica, Smittium culisetae, Smittium sp., Stachylina sp.) and seven are from Tierra del Fuego, the southern tip of South America (H. meridianalis, Glotzia sp., S. culicis, S. cellaspora, S. imitatum, Stachylina minima, Penella simulii). Insect hosts all were immature stages of Culicidae, Simuliidae, Chironomidae, Ceratopogonidae (Insecta: Diptera), and Ephemeroptera and Plecoptera. The lower diversity of Trichomycetes found at Misiones, which has a subtropical climate and rainforest vegetation, was due possibly to the warmer temperatures of the water (15-24 C), compared to the colder streams of Tierra del Fuego (9-15 C), with forests and steppes as typical vegetation.

  16. Ectopsocidae (Psocodea: 'Psocoptera') from Valle del Cauca and NNP Gorgona, Colombia.

    PubMed

    Manchola, Oscar Fernando Saenz; Obando, Ranulfo González; Aldrete, Alfonso N García

    2014-01-01

    The results of a survey of the psocid family Ectopsocidae in Valle del Cauca and NNP Gorgona, are here presented. Fifteen species were identified, in the genera Ectopsocus (14 species), and Ectopsocopsis (one species); four of the Ectopsocus species are new to science and are here described and illustrated. The male of E. thorntoni García Aldrete is here described. Records of Ectopsocopsis cryptomeriae (Enderlein), Ectopsocus briggsi McLachlan, E. californicus Banks, E. columbianus Badonnel, E. maindroni Badonnel, E. meridionalis Ribaga, E. pilosus Badonnel, E. richardsi Pearman, E. titschacki Jentsch, and E. vilhenai Badonnel, are provided. Ten species were found only in Valle del Cauca, two species were found only in the NNP Gorgona, and three species were found at both sites. The specimens studied are deposited in the Entomological Museum, Universidad del Valle, Santiago de Cali, Colombia (MUSENUV). PMID:24869552

  17. Development and Utilization of InDel Markers to Identify Peanut (Arachis hypogaea) Disease Resistance.

    PubMed

    Liu, Lifeng; Dang, Phat M; Chen, Charles Y

    2015-01-01

    Peanut diseases, such as leaf spot and spotted wilt caused by Tomato Spotted Wilt Virus, can significantly reduce yield and quality. Application of marker assisted plant breeding requires the development and validation of different types of DNA molecular markers. Nearly 10,000 SSR-based molecular markers have been identified by various research groups around the world, but less than 14.5% showed polymorphism in peanut and only 6.4% have been mapped. Low levels of polymorphism limit the application of marker assisted selection (MAS) in peanut breeding programs. Insertion/deletion (InDel) markers have been reported to be more polymorphic than SSRs in some crops. The goals of this study were to identify novel InDel markers and to evaluate the potential use in peanut breeding. Forty-eight InDel markers were developed from conserved sequences of functional genes and tested in a diverse panel of 118 accessions covering six botanical types of cultivated peanut, of which 104 were from the U.S. mini-core. Results showed that 16 InDel markers were polymorphic with polymorphic information content (PIC) among InDels ranged from 0.017 to 0.660. With respect to botanical types, PICs varied from 0.176 for fastigiata var., 0.181 for hypogaea var., 0.306 for vulgaris var., 0.534 for aequatoriana var., 0.556 for peruviana var., to 0.660 for hirsuta var., implying that aequatoriana var., peruviana var., and hirsuta var. have higher genetic diversity than the other types and provide a basis for gene functional studies. Single marker analysis was conducted to associate specific marker to disease resistant traits. Five InDels from functional genes were identified to be significantly correlated to tomato spotted wilt virus (TSWV) infection and leaf spot, and these novel markers will be utilized to identify disease resistant genotype in breeding populations.

  18. Origin and distribution of the BRCA2-8765delAG mutation in breast cancer

    PubMed Central

    Palomba, Grazia; Cossu, Antonio; Friedman, Eitan; Budroni, Mario; Farris, Antonio; Contu, Antonio; Pisano, Marina; Baldinu, Paola; Sini, Maria C; Tanda, Francesco; Palmieri, Giuseppe

    2007-01-01

    Background The BRCA2-8765delAG mutation was firstly described in breast cancer families from French-Canadian and Jewish-Yemenite populations; it was then reported as a founder mutation in Sardinian families. We evaluated both the prevalence of the BRCA2-8765delAG variant in Sardinia and the putative existence of a common ancestral origin through a haplotype analysis of breast cancer family members carrying such a mutation. Methods Eight polymorphic microsatellite markers (D13S1250, centromeric, to D13S267, telomeric) spanning the BRCA2 gene locus were used for the haplotype analysis. Screening for the 8765delAG mutation was performed by PCR-based amplification of BRCA2-exon 20, followed by automated sequencing. Results Among families with high recurrence of breast cancer (≥ 3 cases in first-degree relatives), those from North Sardinia shared the same haplotype whereas the families from French Canadian and Jewish-Yemenite populations presented distinct genetic assets at the BRCA2 locus. Screening for the BRCA2-8765delAG variant among unselected and consecutively-collected breast cancer patients originating from the entire Sardinia revealed that such a mutation is present in the northern part of the island only [9/648 (1.4%) among cases from North Sardinia versus 0/493 among cases from South Sardinia]. Conclusion The BRCA2-8765delAG has an independent origin in geographically and ethnically distinct populations, acting as a founder mutation in North but not in South Sardinia. Since BRCA2-8765delAG occurs within a triplet repeat sequence of AGAGAG, our study further confirmed the existence of a mutational hot-spot at this genomic position (additional genetic factors within each single population might be involved in generating such a mutation). PMID:17640379

  19. Development and Utilization of InDel Markers to Identify Peanut (Arachis hypogaea) Disease Resistance

    PubMed Central

    Liu, Lifeng; Dang, Phat M.; Chen, Charles Y.

    2015-01-01

    Peanut diseases, such as leaf spot and spotted wilt caused by Tomato Spotted Wilt Virus, can significantly reduce yield and quality. Application of marker assisted plant breeding requires the development and validation of different types of DNA molecular markers. Nearly 10,000 SSR-based molecular markers have been identified by various research groups around the world, but less than 14.5% showed polymorphism in peanut and only 6.4% have been mapped. Low levels of polymorphism limit the application of marker assisted selection (MAS) in peanut breeding programs. Insertion/deletion (InDel) markers have been reported to be more polymorphic than SSRs in some crops. The goals of this study were to identify novel InDel markers and to evaluate the potential use in peanut breeding. Forty-eight InDel markers were developed from conserved sequences of functional genes and tested in a diverse panel of 118 accessions covering six botanical types of cultivated peanut, of which 104 were from the U.S. mini-core. Results showed that 16 InDel markers were polymorphic with polymorphic information content (PIC) among InDels ranged from 0.017 to 0.660. With respect to botanical types, PICs varied from 0.176 for fastigiata var., 0.181 for hypogaea var., 0.306 for vulgaris var., 0.534 for aequatoriana var., 0.556 for peruviana var., to 0.660 for hirsuta var., implying that aequatoriana var., peruviana var., and hirsuta var. have higher genetic diversity than the other types and provide a basis for gene functional studies. Single marker analysis was conducted to associate specific marker to disease resistant traits. Five InDels from functional genes were identified to be significantly correlated to tomato spotted wilt virus (TSWV) infection and leaf spot, and these novel markers will be utilized to identify disease resistant genotype in breeding populations. PMID:26617627

  20. Epidemiological surveillance of ovine hydatidosis in Tierra del Fuego, Patagonia Argentina, 1997-1999.

    PubMed

    Zanini, Fabián; Gonzalo, Roberto; Pérez, Héctor; Aparici, Inés; Soto, Ximena; Guerrero, Juvenal; Cerrone, Gloria; Elissondo, Celina

    2006-06-15

    Cystic echinococcosis is the most prevalent zoonosis in Tierra del Fuego province, Argentina, with important economic, productive and public health consequences. The present work was performed to determine the ovine prevalence in Tierra del Fuego, Argentina, as well as to evaluate the quality of diagnostic systems in slaughterhouses. Moreover, genetic analyses to characterize the strain of Echinococcus granulosus involved in the region were done. The first actions to perform a diagnosis of the epidemiological situation of hydatidosis in Tierra del Fuego were done between 1976 and 1977. A canine prevalence of 80% and an ovine prevalence of 55% results were obtained. Since 1979 the control program of Hydatidosis of Tierra del Fuego was implemented. It was based on semiannual canine anthelmintic treatment with praziquantel at dose of 5mg/kg, and complemented with sanitary education and canine and ovine epidemiological surveillance. During May 1997-January 1999: 5,916 sheep coming from 20 farms of the programmatic area were evaluated. In the lamb category, hydatid cysts were not found. In the adults category, 62 infected animals were found (3.2%). The ovine prevalence was 1.1% and there was 100% of coincidence between diagnosis in the slaughterhouse, re-inspection in the laboratory and histopathological study. The marked decrease in the prevalence observed for sheep infection evidenced a destabilization of the biological cycle of the parasite. This could be explained by the application of a control program with uninterrupted systematic actions. Polymerase chain reaction-ribosomal ITS-1 DNA (rDNA) restriction fragment length polymorphism (PCR-RFLP) analysis and partial sequencing of the mitochondrial cytochrome c oxidase subunit 1 (CO1) gene were used to characterize E. granulosus isolates collected from different regions of Tierra del Fuego to determine which genotypes occurred in this region. The results revealed the presence of the G1 genotype (sheep-dog strain

  1. A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity

    PubMed Central

    Chothani, Daya L.; Vaghasiya, H. U.

    2011-01-01

    Balanites aegyptiaca Del. (Zygophyllaceae), known as ‘desert date,’ is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature. PMID:22096319

  2. Detection of filaggrin gene mutation (2282del4) in Pakistani Ichthyosis vulgaris families.

    PubMed

    Naz, Naghma; Samdani, Azam Jah

    2011-06-01

    The aim of this study was to detect an 811 bp filaggrin (FLG) gene fragment known to carry a mutation 2282del4 which causes ichthyosis vulgaris. Seven clinically examined ichthyosis vulgaris families were included in this study. An 811 bp FLG gene fragment was targeted in the genomic DNA of all the members of the seven families by PCR amplification using known primers RPT1P7 and RPT2P1. Successful amplification of an 811 bp FLG gene fragment in all the families suggested the possible role of the 2282del4 mutation in causing ichthyosis vulgaris in Pakistani population.

  3. Archivo de placas astrométricas del Observatorio de La Plata

    NASA Astrophysics Data System (ADS)

    di Sisto, R.; Orellana, R. B.

    Se ha realizado una base de datos con las placas fotográficas obtenidas con el Astrográfico del Observatorio de La Plata. Se han clasificado un total de 3000 placas obtenidas para asteroides y cometas. El acceso a la base de datos se hará por FTP y la misma contendrá la siguiente información: fecha y tiempo de exposición, coordenadas del centro de placa, tipo de emulsión fotográfica, estado de la placa, objeto fotografiado.

  4. Black hole remnant and quantum tunnelling in three-dimensional Gödel spacetime

    NASA Astrophysics Data System (ADS)

    Li, Hui-Ling; Zu, Xiao-Tao

    2015-05-01

    Using the modified Dirac equation in a three-dimensional gravity background, we investigate the quantum correction to tunnelling radiation from a Gödel black hole, and discuss the black hole remnant employing fermion's tunnelling. The corrected tunnelling probability is derived, and the modified Hawking temperature is found as well. It is worth emphasizing that, only when the condition j> αω(3 r -- r +) is satisfied, emitting both a mass particle and a massless particle, the remnant of the Gödel black hole may arise.

  5. DELIVERING TIMELY AIR QUALITY, TRAFFIC, AND WEATHER INFORMATION TO YOUR COMMUNITY/THE PASO DEL NORTE ENVIRONMENTAL MONITORING PROJECT

    EPA Science Inventory

    EPA has developed a technology transfer handbook for the EMPACT Paso del Norte Project. The EMPACT Paso del Norte Environmental Monitoring Project is a mobile vehicle emissions project that involves the international community of El Paso, TX; Sundland Park, NM; and Juarez, Mexico...

  6. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and navigation. (a... regulations and monitor traffic through the canal. (c) Safe navigation required. Clearance for any vessel...

  7. 75 FR 44720 - Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Live-Fire Gun Exercise, M/V Del Monte... specified waters of the James River to protect mariners from the hazards associated with live fire and... conduct a live fire and explosive training event onboard the M/V Del Monte in the vicinity of the...

  8. 78 FR 74008 - Amendment of Class E Airspace; Del Rio, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-10

    ... Del Rio, TX, area, creating additional controlled airspace at Laughlin AFB (78 FR 52716) Docket No... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. ] Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  9. Community Arts Programs: Cohesion and Difference Case Studies. Henry Street Settlement and El Museo del Barrio

    ERIC Educational Resources Information Center

    Kiebert-Gruen, Cathleen

    2009-01-01

    A comparative case study of two cultural institutions, Henry Street Settlement and El Museo del Barrio, founded almost eighty years apart, were involved in social justice causes and community arts. Although both of these institutions participated in the political activism of their time, they also demonstrated an important adaptability. They were…

  10. 33 CFR 162.200 - Marina del Rey, Calif.; restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... dealing with this section in 33 CFR Part 207. ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Marina del Rey, Calif... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200...

  11. 33 CFR 162.200 - Marina del Rey, Calif.; restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... dealing with this section in 33 CFR Part 207. ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Marina del Rey, Calif... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200...

  12. Dropouts, Stopouts, Optouts at Del Mar College: Spring 1991. Report of a Joint Research Project.

    ERIC Educational Resources Information Center

    Luckie, Jo Ann I.; Bonham, L. Adrianne

    A research project investigated 2,313 persons who attended Del Mar College (Texas) during fall 1990 but did not enroll for spring 1991. Four sets of data were collected: (1) limited demographic information on the total student body; (2) demographic information drawn from school records to describe all nonreturnees; (3) demographic information…

  13. ATMOSPHERIC VOLATILE ORGANIC COMPOUND MEASUREMENTS DURING THE 1996 PASO DEL NORTE OZONE STUDY

    EPA Science Inventory

    Ambient air VOC samples were collected at surface air quality monitoring sites, near sources of interest, and aloft on the US (El Paso) and Mexican (Ciudad Juarez) side of the border during a six-week period of the 1996 Paso del Norte Ozone Study. Samples were collected at five...

  14. Acantholachesilla gen. n. (Psocodea:'Psocoptera': Lachesillidae: Eolachesillinae: Graphocaeciliini) from Valle del Cauca, Colombia.

    PubMed

    Aldrete, Alfonso N García; Manchola, Oscar Fernando Saenz; Obando, Ranulfo González

    2014-06-25

    Acantholachesilla saltoensis gen. et sp. n. is described from Valle del Cauca, Colombia, in the Lachesillidae, tribe Graphocaeciliini (Eolachesillinae). The genus is related to Dagualachesilla and Dagualachesilloides that occur in the same area, differing from them in the male clunial projection, phallosome, and female subgenital plate and gonapophyses.

  15. 33 CFR 334.110 - Delaware Bay off Cape Henlopen, Del.; naval restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Delaware Bay off Cape Henlopen, Del.; naval restricted area. 334.110 Section 334.110 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS §...

  16. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  17. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  18. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  19. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  20. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  1. New record of Paralomis spinosissima Birstein & Vinogradov (Decapoda: Anomura: Lithodidae) from Mar del Plata, Argentina.

    PubMed

    Olguín, Nicole; Ocampo, Emiliano H; Farias, Nahuel

    2015-05-14

    The lithodid crab Paralomis spinosissima is previously known only in Sub-Antarctic waters from South Georgia Island to the Drake Passage. Here we recorded a juvenile male obtained off shores of Mar del Plata (~37°S), Argentina. This new occurrence extends the distribution range of the species over 1300 km northwards in the Atlantic Ocean.

  2. Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells

    PubMed Central

    Zhang, Donglei; Ciciriello, Fabiana; Anjos, Suzana M.; Carissimo, Annamaria; Liao, Jie; Carlile, Graeme W.; Balghi, Haouaria; Robert, Renaud; Luini, Alberto; Hanrahan, John W.; Thomas, David Y.

    2012-01-01

    Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low temperature incubation (29°C) to traffic to the plasma membrane where it functions as a chloride channel. Here we show that, cardiac glycosides, at nanomolar concentrations, can partially correct the trafficking of F508del-CFTR in human CF bronchial epithelial cells (CFBE41o-) and in an F508del-CFTR mouse model. Comparison of the transcriptional profiles obtained with polarized CFBE41o-cells after treatment with ouabain and by low temperature has revealed a striking similarity between the two corrector treatments that is not shared with other correctors. In summary, our study shows a novel function of ouabain and its analogs in the regulation of F508del-CFTR trafficking and suggests that compounds that mimic this low temperature correction of trafficking will provide new avenues for the development of therapeutics for CF. PMID:23060796

  3. Self-consistent Gödel cosmology with spin-density in Riemann-Cartan spacetime

    NASA Astrophysics Data System (ADS)

    Smalley, Larry L.

    1986-01-01

    We show that the Gödel metric for a rotating cosmology is compatible with the self-consistent formulation of the Einstein-Cartan metric-torsion theory for a spinning fluid. Fruitful discussions with J.R. Ray and F.W. Hehl are greatfully acknowledged. I wish to also thank J. Bradas who brought a reference to my attention.

  4. Calcio y la prevención del cáncer

    Cancer.gov

    Hoja informativa que resume los resultados de estudios sobre el calcio y la prevención del cáncer. Incluye información sobre las recomendaciones dietéticas para calcio y la cantidad de calcio en los alimentos y en complementos de calcio.

  5. Shed Some Light on the Subject: Teaching Ramon del Valle-Inclan's "Luces de bohemia"

    ERIC Educational Resources Information Center

    Parker, Jason Thomas

    2011-01-01

    This essay seeks to provide parallel and interchangeable approaches to teaching Ramon del Valle-Inclan's challenging play "Luces de bohemia". A greater understanding of the cultural and mental frameworks of the early twentieth-century Spanish spectator will permit students to penetrate the dense intertextuality that characterizes Valle's…

  6. Informe del NCI y los CDC sobre el tabaco sin humo

    Cancer.gov

    El primer informe sobre el consumo mundial del tabaco sin humo y sus consecuencias en la salud pública reveló que más de 300 millones de personas en al menos 70 países usan estos productos dañinos.

  7. Exploración del Nuevo Laboratorio Científico de Marte

    NASA Video Gallery

    Únase a Fernando Abilleira, un analista de trayectoria de la NASA para la Oficina de Exploración de Marte, y conozca las nuevas tecnologías que el nuevo robot Curiosity del Laboratorio Científico d...

  8. Se lanza Red Nacional de Estudios Clínicos del NCI

    Cancer.gov

    El Instituto Nacional del Cáncer (NCI) puso en marcha una nueva red de investigación de estudios clínicos con el objetivo de mejorar el tratamiento de más de 1,6 millones de estadounidenses que reciben un diagnóstico de cáncer cada año.

  9. Control del dolor: Apoyo para las personas con cáncer

    Cancer.gov

    Contiene información sobre las medicinas contra el dolor para pacientes con cáncer, los planes para controlarlo, cómo hablar con su equipo de atención médica sobre el dolor que usted siente y qué hacer para controlar los efectos físicos y emocionales del

  10. A tectonically controlled basin-fill within the Valle del Cauca, West-Central Colombia

    SciTech Connect

    Rine, J.M.; Keith, J.F. Jr.; Alfonso, C.A.; Ballesteros, I.; Laverde, F.; Sacks, P.E.; Secor, D.T. Jr. ); Perez, V.E.; Bernal, I.; Cordoba, F.; Numpaque, L.E. )

    1993-02-01

    Tertiary strata of the Valle del Cauca reflect a forearc/foreland basin tectonic history spanning a period from pre-uplift of the Cordillera Central to initiation of uplift of the Cordillera Occidental. Stratigraphy of the Valle del Cauca begins with Jurassic-Cretaceous rocks of exotic and/or volcanic provenance and of oceanic origin. Unconformably overlying these are Eocene to Oligocene basal quartz-rich sandstones, shallow marine algal limestones, and fine-grained fluvial/deltaic mudstones and sandstones with coalbeds. These Eocene to Oligocene deposits represent a period of low tectonic activity. During late Oligocene to early Miocene, increased tectonic activity produced conglomeratic sediments which were transported from east to west, apparently derived from uplift of the Cordillera Central, and deposited within a fluvial to deltaic setting. East-west shortening of the Valle del Cauca basin folded the Eocene to early Miocene units, and additional uplift of the Cordillera Central during the later Miocene resulted in syn-tectonic deposition of alluvial fans. After additional fold and thrust deformation of the total Eocene-Miocene basin-fill, tectonic activity abated and Pliocene-Quaternary alluvial and lacustrine strata were deposited. Within the framework of this depositional and tectonic history of the Valle del Cauca, hydrocarbon exploration strategies can be formulated and evaluated.

  11. Plan Multinacional de Educacion del Adulto (Multinational Plan for Adult Education).

    ERIC Educational Resources Information Center

    Eduplan Informa, 1971

    1971-01-01

    This document contains part of the final report from the first meeting of the Inter-American Council on Education, Science, and Culture, held in Vina del Mar, Chile, in 1970. The report presents general policy and guidelines which should be followed in the establishment of adult elementary education programs. The general discussion covers literacy…

  12. Exploración del Sistema Solar -- Una mirada hacia el futuro

    NASA Video Gallery

    ¿Piensas que ya sabemos todo acerca de nuestro sistema solar? La realidad es que apenas hemos comenzado con lo que hay para conocer. Únete a la NASA, en el envío de misiones a los confines del sist...

  13. A Failed Utopia in Marcela Del Río's "Proceso a Faubritten"

    ERIC Educational Resources Information Center

    Manickam, Samuel

    2014-01-01

    In Marcela del Río's science fiction novel "Proceso a Faubritten," utopia comes in the form of eternal life for all of humanity, thanks to Dr. Alexander Faubritten's "Bomba L." This polyphonic work includes diaries by Faubritten and his Mexican lover, María Corona. In my analysis of these two diaries, I will show how…

  14. Gastrointestinal helminths of Commerson's dolphins Cephalorhynchus commersonii from central Patagonia and Tierra del Fuego.

    PubMed

    Berón-Vera, B; Pedraza, S N; Raga, J A; Gil de Pertierra, A; Crespo, E A; Alonso, M K; Goodall RNP

    2001-12-01

    The stomachs and intestines of 9 Commerson's dolphins incidentally caught in trawl nets in central Patagonia and 23 stranded on beaches in Tierra del Fuego were surveyed for helminth parasites. A total of 267 individuals belonging to 4 species of parasites (1 nematode, 3 digeneans) were found in the dolphins from the first area: Anisakis sp. (larvae type 1 = A. simplex), Braunina cordiformis, Hadwenius sp. and Pholeter gastrophilus. In the Tierra del Fuego dolphins, 142 specimens belonging to 3 species (2 nematodes, 1 digenean, 1 cestode) were found: A. simplex, Hadwenius sp. and Strobilocephalus triangularis. Only 2 of the helminth species were shared in the 2 study areas, A. simplex and Hadwenius sp., and both were more common in central Patagonia. Among the species, A. simplex was most prevalent and abundant in both study areas. In Tierra del Fuego, adults of A. simplex appeared in only 1 host. Hadwenius sp., P. gastrophilus and S. triangularis are new host records for Commerson's dolphin. Species diversity and species richness were low in both study areas. Helminth communities were more diverse in central Patagonia (t = 1.97, df = 258, p < 0.05) and species richness was higher in central Patagonia (S = 4). No differences in diversity were observed between females and males of central Patagonia (t = 1.97, df = 139, p < 0.05) and between females of central Patagonia and Tierra del Fuego. The results may suggest some differences in habitat use, diet and sex between Commerson's dolphin populations in the 2 study areas.

  15. Urban Impact of Dissolved Metals in the Paso del Norte Segment of the Rio Grande

    ERIC Educational Resources Information Center

    Freiwan, Sumayeh Ahmad

    2013-01-01

    The Paso del Norte segment of the Rio Grande experiences two seasons per year; the (wet) irrigation season and the (dry) non-irrigation season. The goal of this study was to improve the understanding of occurrence and contribution of dissolved metals in this region during the non-irrigation season. The objectives of this study were to (1) evaluate…

  16. Tratamiento del cáncer sin daño al corazón

    Cancer.gov

    Investigadores de los campos de oncología y de cardiología están trabajando para encontrar formas de impedir, manejar y posiblemente aun revertir los efectos secundarios cardiovasculares de ciertas terapias del cáncer.

  17. Dolores Del Rio, the First "Latin Invasion", and Hollywood's Transition to Sound

    ERIC Educational Resources Information Center

    Beltran, Mary

    2005-01-01

    The career and promotion of Mexican actress Dolores Del Rio as a case study of how Hollywood's shift to sound film affected Latino and Latina actors is examined. It reveals the way in which the starring opportunities for Latinos dwindled when accent and language increasingly marked them as nonwhite in the 1930s in the talkie films.

  18. Synonymous codon usage affects the expression of wild type and F508del CFTR.

    PubMed

    Shah, Kalpit; Cheng, Yi; Hahn, Brian; Bridges, Robert; Bradbury, Neil A; Mueller, David M

    2015-03-27

    The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel composed of 1480 amino acids. The major mutation responsible for cystic fibrosis results in loss of amino acid residue, F508 (F508del). Loss of F508 in CFTR alters the folding pathway resulting in endoplasmic-reticulum-associated degradation. This study investigates the role of synonymous codon in the expression of CFTR and CFTR F508del in human HEK293 cells. DNA encoding the open reading frame (ORF) for CFTR containing synonymous codon replacements was expressed using a heterologous vector integrated into the genome. The results indicate that the codon usage greatly affects the expression of CFTR. While the promoter strength driving expression of the ORFs was largely unchanged and the mRNA half-lives were unchanged, the steady-state levels of the mRNA varied by as much as 30-fold. Experiments support that this apparent inconsistency is attributed to nonsense mediated decay independent of exon junction complex. The ratio of CFTR/mRNA indicates that mRNA containing native codons was more efficient in expressing mature CFTR as compared to mRNA containing synonymous high-expression codons. However, when F508del CFTR was expressed after codon optimization, a greater percentage of the protein escaped endoplasmic-reticulum-associated degradation resulting in considerable levels of mature F508del CFTR on the plasma membrane, which showed channel activity. These results indicate that codon usage has an effect on mRNA levels and protein expression, for CFTR, and likely on chaperone-assisted folding pathway, for F508del CFTR.

  19. Synonymous Codon Usage Affects the Expression of Wild Type and F508del CFTR

    PubMed Central

    Shah, Kalpit; Cheng, Yi; Hahn, Brian; Bridges, Robert; Bradbury, Neil; Mueller, David M.

    2015-01-01

    The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel composed of 1480 amino acids. The major mutation responsible for cystic fibrosis results in loss of amino acid residue, F508, (F508del). Loss of F508 in CFTR alters the folding pathway resulting in endoplasmic reticulum associated degradation (ERAD). This study investigates the role of synonymous codon in the expression of CFTR and CFTR F508del in human HEK293 cells. DNA encoding the open reading frame (ORF) for CFTR containing synonymous codon replacements, were expressed using a heterologous vector integrated into the genome. The results indicate that the codon usage greatly affects the expression of CFTR. While the promoter strength driving expression of the ORFs was largely unchanged and the mRNA half-lives were unchanged, the steady state levels of the mRNA varied by as much as 30 fold. Experiments support that this apparent inconsistency is attributed to exon junction complex independent nonsense mediated decay. The ratio of CFTR/mRNA indicates that mRNA containing native codons was more efficient in expressing mature CFTR as compared to mRNA containing synonymous high expression codons. However, when F508del CFTR was expressed after codon optimization, a greater percentage of the protein escaped ERAD resulting in considerable levels of mature F508del CFTR on the plasma membrane, which showed channel activity. These results indicate that for CFTR, codon usage has an effect on mRNA levels, protein expression and likely, for F508del CFTR, chaperone assisted folding pathway. PMID:25676312

  20. Determinacion de periodos fundamentales del suelo mediante vibraciones ambientales en el municipio de Humacao, Puerto Rico

    NASA Astrophysics Data System (ADS)

    Cintron Aponte, Rommel

    La tecnica de Nakamura ha sido utilizada a nivel mundial para determinar periodos fundamentales del suelo. La tecnica consiste en calcular y graficar cocientes espectrales H/V de vibraciones ambientales registradas sobre el suelo. Mediciones de vibraciones ambientales fueron tomadas en 151 lugares dentro del municipio de Humacao, localizado al este de Puerto Rico. Los datos se procesaron utilizando espectros de Fourier y espectros de potencia. La tecnica fue validada al compararla con los resultados de cocientes espectrales H/V de registros de sismos debiles y tambien con una modelacion numerica realizada con datos de un ensayo "downhole". Las graficas de los cocientes espectrales H/V fueron divididas en casos y grupos, los cuales dependen de la facilidad para identificar el periodo fundamental pico y amplitudes en frecuencias menores de 1 Hz, respectivamente. Los resultados obtenidos con ambos espectros fueron comparados y se concluye que los mismos se complementan para proveer resultados mas confiables. Se crearon mapas de periodos fundamentales, factores de amplitud, isoperiodos y clasificacion sismica de sitio. Los mapas de isoperiodos fueron realizados en las zonas mas pobladas sobre depositos de suelo. El mapa de periodos fundamentales del suelo mostro buena correlacion con la geologia local. El mapa de clasificacion sismica derivado de periodos de sitio fue comparado con el mapa de clasificacion sismica derivado de barrenos geotecnicos. El mapa de clasificacion obtenido de periodos puede sobreestimar un poco algunas clasificaciones del suelo. Sin embargo, este mapa puede proveer un estimado aproximado de la velocidad de onda de corte promedio del suelo hasta una profundidad de 100 pies (30 metros).

  1. Toric K3-fibred Calabi-Yau manifolds with del Pezzo divisors for string compactifications

    NASA Astrophysics Data System (ADS)

    Cicoli, Michele; Kreuzer, Maximilian; Mayrhofer, Christoph

    2012-02-01

    We analyse several explicit toric examples of compact K3-fibred Calabi-Yau three-folds. These manifolds can be used for the study of string dualities and are crucial ingredients for the construction of LARGE Volume type IIB vacua with promising applications to cosmology and particle phenomenology. In order to build a phenomenologically viable model, on top of the two moduli corresponding to the base and the K3 fibre, we demand also the existence of two additional rigid divisors: the first supporting the non-perturbative effects needed to achieve moduli stabilisation, and the second allowing the presence of chiral matter on wrapped D-branes. We clarify the topology of these rigid divisors by discussing the interplay between a diagonal structure of the Calabi-Yau volume and D-terms. Del Pezzo divisors appearing in the volume form in a completely diagonal way are natural candidates for supporting non-perturbative effects and for quiver constructions, while `non-diagonal' del Pezzo and rigid but not del Pezzo divisors are particularly interesting for model building in the geometric regime. Searching through the existing list of four dimensional reflexive lattice polytopes, we find 158 examples admitting a Calabi-Yau hypersurface with a K3 fibration and four Kähler moduli where at least one of the toric divisors is a `diagonal' del Pezzo. We work out explicitly the topological details of a few examples showing how, in the case of simplicial polytopes, all the del Pezzo divisors are `diagonal', while `non-diagonal' ones appear only in the case of non-simplicial polytopes. A companion paper will use these results in the study of moduli stabilisation for globally consistent explicit Calabi-Yau compactifications with the local presence of chirality.

  2. The Danger from the Outer Space. (Breton Title: O Perigo que Vem do Espaço.) El Peligro que Viene del Espacio

    NASA Astrophysics Data System (ADS)

    Bedaque, Paulo

    2005-12-01

    possíveis "agressores" e na estimativa dos reais riscos que corremos. Entre los muchos riesgos que corre el ambiente terrestre existe la remota posibilidad de choques con pequeños cuerpos celestes como cometas y asteroides, y que pueden provocar desde pequeños daños sin mayores consecuencias hasta cataclismos de grandes dimensiones, con reflejos para toda la vida existente enla Tierra. Latasa de colisiones, como era de esperar, es mucho menor para cuerpos con masas y diámetros crecientes. Es posible realizar simulaciones considerando el diámetro, la masa, su velocidad y el ángulo de la colisión para estimar las probabilidades, las consecuencias para el planeta y con qué tasa temporal podemos esperarlas. Los resultados de estas simulaciones se presentan en gráficos para facilitar el análisis final. Finalmente señalamos que existen varios centros de investigación en el mundo trabajando en barreduras del cielo en busca de posibles "agresores" y en las estimaciones de los riesgos que corremos.

  3. Percepcion de los profesores universitarios acerca del concepto cultura cientifica y de sus implicaciones en el nuevo bachillerato del Recinto de Rio Piedras de la Universidad de Puerto Rico

    NASA Astrophysics Data System (ADS)

    Ramos Pastrana, Nilsa

    El Senado Academico del Recinto de Rio Piedras de la Universidad de Puerto Rico aprobo en el ano academico 2005-2006 la Certificacion 46, que contiene los lineamientos de un nuevo bachillerato. Este nuevo bachillerato introdujo cambios significativos en el curriculo tradicional. Entre ellos se encuentra la reduccion del componente de educacion general y el de Ciencias Biologicas en particular. La reduccion de creditos en el componente de Ciencias Biologicas ha obligado a reevaluar el concepto de cultura cientifica que desarrollan esos cursos. El proposito del estudio consistio en auscultar las percepciones de los profesores de las Facultades de Administracion de Empresas, Humanidades, Ciencias Sociales, Ciencias Naturales, Educacion y Estudios Generales del Recinto de Rio Piedras de la Universidad de Puerto Rico en torno al concepto de cultura cientifica, los contenidos disciplinares del curso de Ciencias Biologicas y la reduccion de creditos en el nuevo bachillerato. Las preguntas que guiaron la investigacion fueron: ¿cuales son las percepciones que tienen los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Estudios Generales, Ciencias Naturales, Humanidades y Educacion, en torno al concepto de cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿cuales son las percepciones que tienen los profesores de Ciencias Biologicas en torno al concepto cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿existen diferencias significativas por facultad, genero, experiencia, rango y nombramiento en las percepciones que tienen los profesores del Recinto de Rio Piedras de la Universidad de Puerto Rico sobre los elementos que caracterizan la cultura cientifica y los contenidos biologicos que deben tener los egresados del Recinto? ¿que implicaciones curriculares tienen estos testimonios en el desarrollo del concepto de cultura cientifica en el nuevo bachillerato? Para realizar la

  4. Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.

    PubMed

    Favia, Maria; Mancini, Maria T; Bezzerri, Valentino; Guerra, Lorenzo; Laselva, Onofrio; Abbattiscianni, Anna C; Debellis, Lucantonio; Reshkin, Stephan J; Gambari, Roberto; Cabrini, Giulio; Casavola, Valeria

    2014-07-01

    Cystic fibrosis transmembrane conductance regulator (CFTR) carrying the F508del mutation is retained in endoplasmic reticulum and fails to traffic to the cell surface where it functions as a protein kinase A (PKA)-activated chloride channel. Pharmacological correctors that rescue the trafficking of F508del CFTR may overcome this defect; however, the rescued F508del CFTR still displays reduced chloride permeability. Therefore, a combined administration of correctors and potentiators of the gating defect is ideal. We recently found that 4,6,4'-trimethylangelicin (TMA), besides inhibiting the expression of the IL-8 gene in airway cells in which the inflammatory response was challenged with Pseudomonas aeruginosa, also potentiates the cAMP/PKA-dependent activation of wild-type CFTR or F508del CFTR that has been restored to the plasma membrane. Here, we demonstrate that long preincubation with nanomolar concentrations of TMA is able to effectively rescue both F508del CFTR-dependent chloride secretion and F508del CFTR cell surface expression in both primary or secondary airway cell monolayers homozygous for F508del mutation. The correction effect of TMA seems to be selective for CFTR and persisted for 24 h after washout. Altogether, the results suggest that TMA, besides its anti-inflammatory and potentiator activities, also displays corrector properties.

  5. Development of InDel markers for Brassica rapa based on whole-genome re-sequencing.

    PubMed

    Liu, Bo; Wang, Yan; Zhai, Wen; Deng, Jie; Wang, Hui; Cui, Yang; Cheng, Feng; Wang, Xiaowu; Wu, Jian

    2013-01-01

    Genome-wide detection of short insertion/deletion length polymorphisms (InDels, <5 bp) in Brassica rapa (named the A genome) was performed by comparing whole-genome re-sequencing data from two B. rapa accessions, L144 and Z16, to the reference genome sequence of Chiifu-401-42. In total, we identified 108,558 InDel polymorphisms between Chiifu-401-42 and L144, 26,795 InDels between Z16 and Chiifu-401-42, and 26,693 InDels between L144 and Z16. From these, 639 InDel polymorphisms of 3-5 bp in length between L144 and Z16 were selected for experimental validation; 491 (77%) yielded single PCR fragments and showed polymorphisms, 7 (1%) did not amplify a product, and 141 (22%) showed no polymorphism. For further validation of these intra-specific InDel polymorphisms, 503 candidates, randomly selected from the 639 InDels, were screened across seven accessions representing different B. rapa cultivar groups. Of these assayed markers, 387 (77%) were polymorphic, 111 (22%) were not polymorphic and 5 (1%) did not amplify a PCR product. Furthermore, we randomly selected 518 InDel markers to validate their polymorphism in B. napus (the AC genome) and B. juncea (the AB genome), of which more than 90% amplified a PCR product; 132 (25%) showed polymorphism between the two B. napus accessions and 41 (8%) between the two B. juncea accessions. This set of novel PCR-based InDel markers will be a valuable resource for genetic studies and breeding programs in B. rapa.

  6. CHEK2*1100delC homozygosity in the Netherlands--prevalence and risk of breast and lung cancer.

    PubMed

    Huijts, Petra E A; Hollestelle, Antoinette; Balliu, Brunilda; Houwing-Duistermaat, Jeanine J; Meijers, Caro M; Blom, Jannet C; Ozturk, Bahar; Krol-Warmerdam, Elly M M; Wijnen, Juul; Berns, Els M J J; Martens, John W M; Seynaeve, Caroline; Kiemeney, Lambertus A; van der Heijden, Henricus F; Tollenaar, Rob A E M; Devilee, Peter; van Asperen, Christi J

    2014-01-01

    The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from North-West Europe. Women heterozygous for 1100delC have an increased breast cancer risk (odds ratio 2.7). To explore the prevalence and clinical consequences of 1100delC homozygosity in the Netherlands, we genotyped a sporadic breast cancer hospital-based cohort, a group of non-BRCA1/2 breast cancer families, and breast tumors from a tumor tissue bank. Three 1100delC homozygous patients were found in the cohort of 1434 sporadic breast cancer patients, suggesting an increased breast cancer risk for 1100delC homozygotes (odds ratio 3.4, 95% confidence interval 0.4-32.6, P=0.3). Another 1100delC homozygote was found in 592 individuals from 108 non-BRCA1/2 breast cancer families, and two more were found after testing 1706 breast tumors and confirming homozygosity on their wild-type DNA. Follow-up data was available for five homozygous patients, and remarkably, three of them had developed contralateral breast cancer. A possible relationship between 1100delC and lung cancer risk was investigated in 457 unrelated lung cancer patients but could not be confirmed. Due to the small number of 1100delC homozygotes identified, the breast cancer risk estimate associated with this genotype had limited accuracy but is probably higher than the risk in heterozygous females. Screening for CHEK2 1100delC could be beneficial in countries with a relatively high allele frequency.

  7. Development of InDel markers for Brassica rapa based on whole-genome re-sequencing.

    PubMed

    Liu, Bo; Wang, Yan; Zhai, Wen; Deng, Jie; Wang, Hui; Cui, Yang; Cheng, Feng; Wang, Xiaowu; Wu, Jian

    2013-01-01

    Genome-wide detection of short insertion/deletion length polymorphisms (InDels, <5 bp) in Brassica rapa (named the A genome) was performed by comparing whole-genome re-sequencing data from two B. rapa accessions, L144 and Z16, to the reference genome sequence of Chiifu-401-42. In total, we identified 108,558 InDel polymorphisms between Chiifu-401-42 and L144, 26,795 InDels between Z16 and Chiifu-401-42, and 26,693 InDels between L144 and Z16. From these, 639 InDel polymorphisms of 3-5 bp in length between L144 and Z16 were selected for experimental validation; 491 (77%) yielded single PCR fragments and showed polymorphisms, 7 (1%) did not amplify a product, and 141 (22%) showed no polymorphism. For further validation of these intra-specific InDel polymorphisms, 503 candidates, randomly selected from the 639 InDels, were screened across seven accessions representing different B. rapa cultivar groups. Of these assayed markers, 387 (77%) were polymorphic, 111 (22%) were not polymorphic and 5 (1%) did not amplify a PCR product. Furthermore, we randomly selected 518 InDel markers to validate their polymorphism in B. napus (the AC genome) and B. juncea (the AB genome), of which more than 90% amplified a PCR product; 132 (25%) showed polymorphism between the two B. napus accessions and 41 (8%) between the two B. juncea accessions. This set of novel PCR-based InDel markers will be a valuable resource for genetic studies and breeding programs in B. rapa. PMID:22972202

  8. Insertion of Astronomy as a High School Subject. (Spanish Title: Inserción de Astronomia Como Materia del Ciclo Secundario.) Inserção da Astronomia Como Disciplina Curricular do Ensino Médio

    NASA Astrophysics Data System (ADS)

    Dias, Claudio André C. M.; Santa Rita, Josué R.

    2008-12-01

    Astronomy is considered among the first sciences that man dominated, however, the basic skills for the construction of knowledge, relatively to the contents "Earth and the Universe" are not being developed properly for the majority of students concluding the high school level. The students are concluding this teaching cycle without proper knowledge of several subjects in the area of Astronomy, which are mandatory in the national Curricular National Parameters (PCN). Because of this discrepancy, this work stresses the need of the incorporation of a specific subject of Astronomy in the high school, in order to reduce the gap between what is taught and which should be taught. La Astronomía es considerada una de las primeras ciencias que el hombre dominó. Sin embargo, las habilidades básicas para la construcción del conocimento, relativo al eje temático "Tierra y Universo", no vienen siendo trabajadas adecuadamente con la mayoría de los alumnos que concluyen el ciclo escolar medio. Los alumnos están concluyendo este nivel de enseñanza sin conocimentos de varios temas en el área de Astronomía, que son obligatorios según los Parámetros Curriculares Nacionales (PCN). En virtud de esta discrepancia, este trabajo enfatiza la necesidad de incorporar una disciplina específica de Astronomía em el ciclo medio, em pro de la reducción de las distorsiones entre lo que es enseñado y lo que se debe enseñar. A Astronomia é considerada uma das primeiras ciências que o homem dominou, porém as competências básicas para a construção do conhecimento, relativo ao eixo temático "Terra e Universo", não vêm sendo trabalhadas a contento com a maioria dos alunos que concluem o ensino médio. Os alunos estão concluindo este nível de ensino sem conhecimento de vários temas na área de Astronomia, que são obrigatórios nos Parâmetros Curriculares Nacionais (PCN). Em virtude desta discrepância, este trabalho vem evidenciar a necessidade da incorporação de uma

  9. Rescue of F508del-CFTR by RXR motif inactivation triggers proteome modulation associated with the unfolded protein response.

    PubMed

    Gomes-Alves, Patrícia; Couto, Francisco; Pesquita, Cátia; Coelho, Ana V; Penque, Deborah

    2010-04-01

    F508del-CFTR, the most common mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, disrupts intracellular trafficking leading to cystic fibrosis (CF). The trafficking defect of F508del-CFTR can be rescued by simultaneous inactivation of its four RXR motifs (4RK). Proteins involved in the F508del-CFTR trafficking defect and/or rescue are therefore potential CF therapeutic targets. We sought to identify these proteins by investigating differential proteome modulation in BHK cells over-expressing wt-CFTR, F508del-CFTR or the revertant F508del/4RK-CFTR. By 2-dimensional electrophoresis-based proteomics and western blot approaches we demonstrated that over-expression of F508del/4RK-CFTR modulates the expression of a large number of proteins, many of which are reported interactors of CFTR and/or 14-3-3 with potential roles in CFTR trafficking. GRP78/BiP, a marker of ER stress and unfolded protein response (UPR), is up-regulated in cells over-expressing either F508del-CFTR or F598del/4RK-CFTR. However, over-expression of F508del/4RK-CFTR induces the up-regulation of many other UPR-associated proteins (e.g. GRP94, PDI, GRP75/mortalin) and, interestingly, the down-regulation of proteasome components associated with CFTR degradation, such as the proteasome activator PA28 (PSME2) and COP9 signalosome (COPS5/CSN5). Moreover, the F508del-CFTR-induced proteostasis imbalance, which involves some heat shock chaperones (e.g. HSP72/Hpa2), ER-EF-hand Ca(2+)-binding proteins (calumenin) and the proteasome activator PA28 (PSME2), tends to be 'restored', i.e., in BHK cells over-expressing F508del/4RK-CFTR those proteins tend to have expression levels similar to the wild-type ones. These findings indicate that a particular cellular environment orchestrated by the UPR contributes to and/or is compatible with F508del/4RK-CFTR rescue. PMID:20044041

  10. Estudio del Hidrógeno neutro en dirección al remanente de supernova W28

    NASA Astrophysics Data System (ADS)

    Dubner, G.; Velazquez, P.; Green, A.; Goss, W. M.; Reynoso, E.

    Se presenta un relevamiento del hidrógeno neutro alrededor del remanente de supernova W28 realizado con el radiotelescopio australiano de Parkes. Se analizan rasgos de emisión y absorción. Se muestra la existencia de estructuras anulares asociadas con el remanente. Se compara la distribución del hidrógeno neutro con la ubicación de máseres de OH detectados en la línea de 1720 MHz.

  11. Rescue of F508del-CFTR by RXR motif inactivation triggers proteome modulation associated with the unfolded protein response.

    PubMed

    Gomes-Alves, Patrícia; Couto, Francisco; Pesquita, Cátia; Coelho, Ana V; Penque, Deborah

    2010-04-01

    F508del-CFTR, the most common mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, disrupts intracellular trafficking leading to cystic fibrosis (CF). The trafficking defect of F508del-CFTR can be rescued by simultaneous inactivation of its four RXR motifs (4RK). Proteins involved in the F508del-CFTR trafficking defect and/or rescue are therefore potential CF therapeutic targets. We sought to identify these proteins by investigating differential proteome modulation in BHK cells over-expressing wt-CFTR, F508del-CFTR or the revertant F508del/4RK-CFTR. By 2-dimensional electrophoresis-based proteomics and western blot approaches we demonstrated that over-expression of F508del/4RK-CFTR modulates the expression of a large number of proteins, many of which are reported interactors of CFTR and/or 14-3-3 with potential roles in CFTR trafficking. GRP78/BiP, a marker of ER stress and unfolded protein response (UPR), is up-regulated in cells over-expressing either F508del-CFTR or F598del/4RK-CFTR. However, over-expression of F508del/4RK-CFTR induces the up-regulation of many other UPR-associated proteins (e.g. GRP94, PDI, GRP75/mortalin) and, interestingly, the down-regulation of proteasome components associated with CFTR degradation, such as the proteasome activator PA28 (PSME2) and COP9 signalosome (COPS5/CSN5). Moreover, the F508del-CFTR-induced proteostasis imbalance, which involves some heat shock chaperones (e.g. HSP72/Hpa2), ER-EF-hand Ca(2+)-binding proteins (calumenin) and the proteasome activator PA28 (PSME2), tends to be 'restored', i.e., in BHK cells over-expressing F508del/4RK-CFTR those proteins tend to have expression levels similar to the wild-type ones. These findings indicate that a particular cellular environment orchestrated by the UPR contributes to and/or is compatible with F508del/4RK-CFTR rescue.

  12. Physiological profile of fighters influences training organisation in combat sports: response to Del Vecchio, Hirata, and Franchini (2011).

    PubMed

    Paillard, Thierry

    2011-12-01

    The article by Del Vecchio, et al. (2011) provides relevant information to trainers about the effort-pause ratio during mixed martial arts matches. Taking into account the physiological profiles of fighters would increase interest in these findings. PMID:22403925

  13. Ground Gravity, Magnetic and Electromagnetic Surveys on a Crater on Basalt of Bajada del Diablo Astrobleme-Strewn Field

    NASA Astrophysics Data System (ADS)

    Acevedo, R. D.; Prezzi, C.; Orgeira, M. J.; Rocca, M.; Martínez, O.; Ponce, J. F.; Corbella, H.; Rabassa, J.; González-Guillot, M.; Subías, I.

    2014-09-01

    With the aim of further investigate the circular structures from Bajada del Diablo, we carried out geophysics surveys and we conclude that the geophysical features could be satisfactorily explained assuming an extra-terrestrial projectile impact.

  14. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF TRANSPORTATION Surface Transportation Board Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen... Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and Richard Kosiba...

  15. Medición de densidades medias de meteoritos: test del método de inmersión

    NASA Astrophysics Data System (ADS)

    Steren, G.

    Se evaluó una técnica simple para medir las densidades medias de meteoritos, basada en el Método de Arquímedes y que utiliza cuentas de vidrio de 40μ en lugar de un fluído esto presenta la ventaja de no ser intrusivo ni químicamente reactivo (D.Britt and G.Consolmagno, 1996, B.A.A.S.28,1106). El estudio, realizado en junio de este año por participantes de la VI Escuela de Verano del Observatorio del Vaticano, empleó 37 muestras de la colección del Observatorio del Vaticano, de las cuales 26 eran Condritas, 1 Pallasita y 1 Howardita; algunas de ellas ya habian sido estudiadas por otras técnicas aunque también se incluyeron muestras no estudiadas anteriormente.

  16. del Nido versus St. Thomas Cardioplegia Solutions: A Single-Center Retrospective Analysis of Post Cross-Clamp Defibrillation Rates.

    PubMed

    Buel, Shane T; Striker, Carrie Whittaker; O'Brien, James E

    2016-06-01

    There are many cardioplegia solutions currently in use for pediatric cardiopulmonary bypass (CPB). The most common being del Nido solution. Another common cardioplegia solution used for pediatric CPB is St. Thomas. In October 2014, Children's Mercy Kansas City changed from the use of modified St. Thomas to del Nido. This study compared rates of post cross-clamp fibrillation requiring defibrillation between del Nido solution and modified St. Thomas solution stratified by weight at Children's Mercy Kansas City. This retrospective study consisted of 394 patients who underwent cardiac surgery requiring cardioplegia between January 1, 2014 and July 31, 2015. The outcome measured was defibrillation upon cross-clamp removal. Statistical significance was determined using Fishers exact test with a two-sided significance level of .05. Incidence of defibrillation post cross-clamp removal was 4.4% in the del Nido group and 26.8% in the St. Thomas group (p < .0001). Analysis by weight stratifications displays a reduction in post cross-clamp defibrillation rates in groups using the del Nido solution. The 0- to 6-kg category had an incidence of fibrillation of 1.23% in the del Nido group and 17.5% in the St. Thomas group (p < .0003). The 6- to 15-kg category had an incidence of defibrillation of 1.82% in the del Nido group and 14% in the St. Thomas group (p < .0198). The 15- to 60-kg category had an incidence of defibrillation of 8.9% in the del Nido group and 61% in the St. Thomas group (p < .0001). The >60-kg category had an incidence of defibrillation of 16.7% in the del Nido group and 63% in the St. Thomas group (p < .0623). This study demonstrates a 6-fold decrease in the overall rate of defibrillation post cross-clamp removal between St. Thomas and del Nido cardioplegia solutions. Analyses of weight stratifications demonstrate a decrease in the rate of defibrillation post cross-clamp removal in all categories within the del Nido group. PMID:27578896

  17. Lumacaftor/ivacaftor combination for cystic fibrosis patients homozygous for Phe508del-CFTR.

    PubMed

    Zhang, W; Zhang, X; Zhang, Y H; Strokes, D C; Naren, A P

    2016-04-01

    Cystic fibrosis (CF) is a life-shortening inherited disease caused by the loss or dysfunction of the CF transmembrane conductance regulator (CFTR) channel activity resulting from mutations in the CFTR gene. Phe508del is the most prevalent mutation, with approximately 90% of all CF patients carrying it on at least one allele. Over the past two or three decades, significant progress has been made in understanding the pathogenesis of CF, and in the development of effective CF therapies. The approval of Orkambi® (lumacaftor/ivacaftor) marks another milestone in CF therapeutics development, which, with the advent of personalized medicine, could potentially revolutionize CF care and management. This article reviews the rationale, progress and future direction in the development of lumacaftor/ivacaftor combination to treat CF patients homozygous for the Phe508del-CFTR mutation. PMID:27252987

  18. A Neandertal mandible from the Cova del Gegant (Sitges, Barcelona, Spain).

    PubMed

    Daura, J; Sanz, M; Subirá, M E; Quam, R; Fullola, J M; Arsuaga, J L

    2005-07-01

    A human mandible from the site of Cova del Gegant is described here for the first time and compared with other Middle and Upper Pleistocene representatives of the genus Homo from Europe and Southwest Asia. The specimen was recovered from sediments which also yielded Mousterian stone tools and Pleistocene fauna. The preserved morphology of the mandible, particularly in the region of the mental foramen, clearly aligns it with the Neandertals, making the Cova del Gegant the only known site in Catalonia documenting diagnostic human skeletal remains in association with Middle Paleolithic stone tools. This represents an important new addition to the human fossil record from the Iberian Peninsula and joins the Bañolas mandible in documenting the course of human evolution in the northern Mediterranean region of Spain.

  19. Lumacaftor/ivacaftor combination for cystic fibrosis patients homozygous for Phe508del-CFTR.

    PubMed

    Zhang, W; Zhang, X; Zhang, Y H; Strokes, D C; Naren, A P

    2016-04-01

    Cystic fibrosis (CF) is a life-shortening inherited disease caused by the loss or dysfunction of the CF transmembrane conductance regulator (CFTR) channel activity resulting from mutations in the CFTR gene. Phe508del is the most prevalent mutation, with approximately 90% of all CF patients carrying it on at least one allele. Over the past two or three decades, significant progress has been made in understanding the pathogenesis of CF, and in the development of effective CF therapies. The approval of Orkambi® (lumacaftor/ivacaftor) marks another milestone in CF therapeutics development, which, with the advent of personalized medicine, could potentially revolutionize CF care and management. This article reviews the rationale, progress and future direction in the development of lumacaftor/ivacaftor combination to treat CF patients homozygous for the Phe508del-CFTR mutation.

  20. Highly ordered antigorite from Cerro del Almirez HP-HT serpentinites, SE Spain

    NASA Astrophysics Data System (ADS)

    Padrón-Navarta, J. A.; López Sánchez-Vizcaíno, V.; Garrido, C. J.; Gómez-Pugnaire, M. T.; Jabaloy, A.; Capitani, G. C.; Mellini, M.

    2008-11-01

    The Cerro del Almirez ultramafic massif offers an example of high pressure and high temperature antigorite serpentinites. A sharp antigorite-out isograd separates them from Chl-harzburgites, consisting of olivine + enstatite + chlorite. Antigorite is characterized by aluminium contents as high as 4 wt.% Al2O3. The microstructural study shows that, prior to the transformation, antigorite is exceptionally ordered and consists of the polysome m = 17. No polysomatic defect occurs in antigorite forming most of the Cerro del Almirez serpentinites. Close to the antigorite-out isograd, limited disorder features may occur, mainly as (001) twins, reaction rims and reduction of m down to 14-15. Here, local recrystallization phenomena lead to sporadic growth of large antigorite and chlorite crystals.

  1. PREVENCIÓN DEL VIH/SIDA EN LOS CIRCUITOS DE LEVANTE HSH: UNA ASIGNATURA PENDIENTE.

    PubMed

    Barreda, Victoria; Carballo-Dieguez, Alex; Marone, Rubén; Balán, Iván; Pando, María Ángeles; Avila, María Mercedes

    2010-12-01

    A partir de un relevamiento de tipo etnográfico, se describen lugares de encuentro de HSH en la Ciudad de Buenos Aires y sus prácticas sexuales. El reconocimiento de tales espacios, así como las características que asumen en ellos los encuentros sexuales entre los HSH, plantean obstáculos específicos en la adopción de comportamientos preventivos y, asimismo, generan nuevos desafíos para las actividades de prevención. Se plantean las dificultades y debates conceptuales que la misma categoría presenta, y sus consecuencias en el abordaje preventivo y teórico-metodológico para las ciencias sociales. Además, se proponen nuevos interrogantes acerca de los alcances y las limitaciones del modelo preventivo del VIH/Sida para HSH.

  2. Informe trata el descenso del cáncer y los tumores cerebrales

    Cancer.gov

    Los índices de mortalidad en los Estados Unidos de todos los cánceres en hombres y mujeres siguieron bajando entre 2003 y 2007, que es el período más reciente del que se disponen datos, según el último Informe Anual a la Nación sobre el Estado del Cáncer. El informe encuentra también que el índice general combinado de nuevos diagnósticos de cáncer en hombres y mujeres decreció un promedio un poco menos de 1% por año en el mismo período.

  3. Detection of super-soft emission in nova V339 Del

    NASA Astrophysics Data System (ADS)

    Page, K. L.; Osborne, J. P.; Kuin, N. P. M.; Woodward, C. E.; Schwarz, G. J.; Starrfield, S.; Shore, S. N.; Walter, F. M.

    2013-10-01

    Swift has been regularly observing the fourth LAT-detected classical nova (ATEL #5302) V339 Del (Nova Del 2013; PNV J20233073+2046041) since its outburst on 2013 August 14. Once optical loading had been correctly accounted for (ATel #5429), a real X-ray source was first detected on September 19. The XRT 0.3-10 keV X-ray count rate has been slowly rising since this time, from a value of (1.8 +0.7/-0.6)x10-3 count s-1 on September 19 to (7 +/- 2)x10-3 count s-1 on October 8 [these count rates are from grade 0 (single pixel) events only, to mitigate any residual optical loading effects].

  4. PREVENCIÓN DEL VIH/SIDA EN LOS CIRCUITOS DE LEVANTE HSH: UNA ASIGNATURA PENDIENTE.

    PubMed

    Barreda, Victoria; Carballo-Dieguez, Alex; Marone, Rubén; Balán, Iván; Pando, María Ángeles; Avila, María Mercedes

    2010-12-01

    A partir de un relevamiento de tipo etnográfico, se describen lugares de encuentro de HSH en la Ciudad de Buenos Aires y sus prácticas sexuales. El reconocimiento de tales espacios, así como las características que asumen en ellos los encuentros sexuales entre los HSH, plantean obstáculos específicos en la adopción de comportamientos preventivos y, asimismo, generan nuevos desafíos para las actividades de prevención. Se plantean las dificultades y debates conceptuales que la misma categoría presenta, y sus consecuencias en el abordaje preventivo y teórico-metodológico para las ciencias sociales. Además, se proponen nuevos interrogantes acerca de los alcances y las limitaciones del modelo preventivo del VIH/Sida para HSH. PMID:21874154

  5. A new species of Rhadinella (Serpentes: Colubridae) from the Sierra Madre del Sur of Guerrero, Mexico.

    PubMed

    Campillo, Gustavo; Dávila-Galavíz, Luis Fernando; Flores-Villela, Oscar; Campbell, Jonathan A

    2016-04-12

    We describe a new species of Rhadinella from the Sierra Madre del Sur of Guerrero, Mexico, a region where the genus was previously unknown. This diminutive species is a member of a group of snakes previously allocated in the Rhadinaea godmani group, and more recently transferred to the genus Rhadinella. These snakes may have conspicuous dark longitudinal striping on a pale brown to orange background or may have dark brown to blackish dorsal ground coloration, which mostly or completely obfuscates a pattern of longitudinal striping. The new species is mostly dark with barely discernible slightly paler or darker striping (depending on how striping is interpreted). The closest relative of the new species, on the basis of morphological similarities and biogeography, appears to be Rhadinella donaji which occurs to the east in the Sierra Madre del Sur of Oaxaca about 275 km from the type-locality of the new species.

  6. DEL RBC transfusion should be avoided in particular blood recipient in East Asia due to allosensitization and ineffectiveness*

    PubMed Central

    Shao, Chao-peng; Wang, Bao-yan; Ye, Shi-hui; Zhang, Wen-li; Xu, Hua; Zhuang, Nai-bao; Wu, Xiao-ying; Xu, Heng-gui

    2012-01-01

    Previously, both primary and secondary anti-D alloimmunizations induced by “Asian type” DEL (RHD1227A allele) were observed in two incidents. We investigated how often these alloimmunization events occur. The transfusions of any D-negative patients were investigated in the First Affiliated Hospital of Xi’an Jiaotong University Medical College, China, during the entire 2009. The antigens of D, C, c, E, and e were routinely serotyped. The “Asian type” DEL variant was genotyped and the RHD heterozygote was determined through two published methods. The changes in anti-D levels were monitored by the indirect antiglobulin test (IAT) and flow cytometry. Thirty D-negative transfused patients were included in the study. We focused on 11 recipients who were transfused with packed red blood cells (RBCs) from DEL donors at least one time. Of those 11 recipients, seven were anti-D negative before transfusion and four were anti-D positive (one patient with an autoantibody). One of the seven pre-transfusion anti-D negative patients produced a primary-response anti-D after being transfused with 400 ml of DEL blood twice. All four pre-transfusion antibody positive patients were not observed hemoglobin (Hb) levels increased, as expected after transfusions. Two patients had an increase in anti-D from 1:8 to 1:64 by IAT, which was also shown by flow cytometry. None of the patients experienced an acute hemolytic episode. Our data indicated that the primary anti-D induced by DEL transfusion or the secondary anti-D elevated by DEL in a truly D-negative patient might not be unusual. We suggest that a truly D-negative childbearing-aged woman should avoid DEL transfusion to protect her from primary anti-D allosensitization. In addition, anti-D positive recipients should also avoid DEL red cell transfusion due to the delayed hemolytic transfusion reaction (DHTR). PMID:23125084

  7. Violación del Principio de Equivalencia en Teorías con Dilatón de Cuerdas

    NASA Astrophysics Data System (ADS)

    Landau, S. J.; Sisterna, P. D.; Vucetich, H.

    Se estudian las violaciones al Principio de Equivalencia en Teorías con Dilatón de Cuerdas. En estos modelos, algunas de las constantes fundamentales dependen del espacio y del tiempo. Se muestra que los experimentos de caída libre no tienen aún precisión como para poner límites a los parámetros de la teoría.

  8. La reconstrucción del seno después de una mastectomía

    Cancer.gov

    Hoja informativa que describe la reconstrucción del seno (mama) después de una mastectomía. Contiene información sobre las opciones quirúrgicas, los cuidados de seguimiento y los exámenes de detección del cáncer de seno después de la reconstrucción.

  9. Estimaciones de Prevalencia del VIH por Género y Grupo de Riesgo en Tijuana, México: 2006

    PubMed Central

    Iñiguez-Stevens, Esmeralda; Brouwer, Kimberly C.; Hogg, Robert S.; Patterson, Thomas L.; Lozada, Remedios; Magis-Rodriguez, Carlos; Elder, John P.; Viani, Rolando M.; Strathdee, Steffanie A.

    2010-01-01

    OBJETIVO Estimar la prevalencia del VIH en adultos de 15-49 años de edad en Tijuana, México - en la población general y en subgrupos de riesgo en el 2006. METODOS Se obtuvieron datos demográficos del censo Mexicano del 2005, y la prevalencia del VIH se obtuvo de la literatura. Se construyó un modelo de prevalencia del VIH para la población general y de acuerdo al género. El análisis de sensibilidad consistió en estimar errores estándar del promedio-ponderado de la prevalencia del VIH y tomar derivados parciales con respecto a cada parámetro. RESULTADOS La prevalencia del VIH es 0.54%(N = 4,347) (Rango: 0.22%–0.86%, (N = 1,750–6,944)). Esto sugiere que 0.85%(Rango: 0.39%–1.31%) de los hombres y 0.22%(Rango: 0.04%–0.40%) de las mujeres podrían ser VIH-positivos. Los hombres que tienen sexo con hombres (HSH), las trabajadoras sexuales usuarias de drogas inyectables (MTS-UDI), MTS-noUDI, mujeres UDI, y los hombres UDI contribuyeron las proporciones más elevadas de personas infectadas por el VIH. CONCLUSIONES El número de adultos VIH-positivos entre subgrupos de riesgo en la población de Tijuana es considerable, marcando la necesidad de enforcar las intervenciones de prevención en sus necesidades específicas. El presente modelo estima que hasta 1 en cada 116 adultos podrían ser VIH-positivos. PMID:19685824

  10. The birth of oligodendrocytes in the anatomical and neuropathological literature: the seminal contribution of Pio del Rio-Hortega. 1921.

    PubMed

    Lassmann, Hans

    2012-01-01

    Comment on: del Río-Hortega P. Glia with very few processes (oligodendroglia). Clin Neuropathol. 2012; 31: 440-459, originally published in Archivos de Neurobiología. 1921; 2: 16-43 and del Río-Hortega P. Are the glia with very few processes homologous with Schwann cells? Clin Neuropathol. 2012; 31: 460-462, originally published in Bol de la Soc Esp de Biol. 1922; X: 25-28. PMID:22943958

  11. The CHEK2 del5395 is a founder mutation without direct effects for cancer risk in the latvian population

    PubMed Central

    Kalniete, D; Nakazawa-Miklasevica, M; Irmejs, A; Vjaters, E; Gardovskis, J; Miklasevics, E

    2015-01-01

    Abstract Our objective was to determine: 1) whether the checkpoint kinase 2 (CHEK2) del5395 (g.27417113-27422508 del, NC_000022.11) is a founder mutation in the Latvian population, 2) if there is an association between CHEK2 del5395 mutation and cancer risk, and 3) and whether the CHEK2 del5395 mutation impacts cancer predisposition in Chernobyl disaster liquidators (the civil and military personnel who were called upon to deal with consequences of the 1986 nuclear disaster) as well as geriatric populations. We recruited 438 breast cancer patients, 568 colorectal cancer patients, 399 ovarian cancer patients, 419 prostate cancer patients, 526 healthy blood donors, 480 Chernobyl disaster liquidators and 444 geriatric cancer-free participants. DNA samples were isolated from blood samples and subjected to multiplex polymerase chain reaction (PCR). The truncation of del5395 was estimated by fragment size of the multiplex PCR.All groups were compared to the healthy blood donors using Fisher’s exact test. All p values were two-sided and the odds ratios (OR) calculated by two-by-two table. In cancer groups, the del5395 mutation was most frequently observed in the ovarian cancer group (1.00%, OR = 1.32). In control groups, the del5395 mutation was most frequent (0.76%) in the healthy donors, which exceeded its frequency in the Chernobyl liquidators group and the geriatric group by 0.01 and 0.08%, respectively. For all groups, the OR appeared to be >1 only in ovarian cancer patients. However, OR rates showed no statistical significance in either cancer or control groups, with the p value fluctuating within the range of 0.39-1.00. The CHEK2 gene del5395 is a founder mutation in the Latvian population, which, however, does not have a direct impact on genetic predisposition toward colorectal, breast, ovarian and prostate cancer. PMID:27785394

  12. [The scientific progress of the "Clinica del Lavoro Luigi Devoto" as seen through the contents of the journal "La Medicina del Lavoro". ].

    PubMed

    Foà, V; Camerino, Donatella

    2003-01-01

    On occasion of the Centenary of the "Clinica del Lavoro Luigi Devoto", its researchers suggested that awareness of its historical identity and scientific development should constitute the basis for the future of the Institution. The directors of the Institute who have succeeded one to the other over the years have left a vivid report of the vast amount of work developed in several research fields and also of the original results achieved with significant impact on the scientific community and on society. Content analysis of "La Medicina del Lavoro" allowed us to shed light on strong bonds existing between manufacturing techniques, work organization and health, in the different political and social periods in which they developed. Many actions have been defined and several research subjects have been renewed (according to current demands and new methodological possibilities) between the past and the present, nevertheless many new approaches need to be taken in the fields of epidemiology, indoor air quality, ergophthalmology, muskuloskeletal disorders, environmental and molecular toxicology, and further research will be undertaken thanks to the potential of this discipline for the future. The aim of this report is also to express our thanks to all the medical and non-medical staff who have made their contribution over 100 years of engagement.

  13. Sanger Sequencing for BRCA1 c.68_69del, BRCA1 c.5266dup and BRCA2 c.5946del Mutation Screen on Pap Smear Cytology Samples.

    PubMed

    Lee, Sin Hang; Zhou, Shaoxia; Zhou, Tianjun; Hong, Guofan

    2016-02-08

    Three sets of polymerase chain reaction (PCR) primers were designed for heminested PCR amplification of the target DNA fragments in the human genome which include the site of BRCA1 c.68_69del, BRCA1 c.5266dup and BRCA2 c.5946del respectively, to prepare the templates for direct Sanger sequencing screen of these three founder mutations. With a robust PCR mixture, crude proteinase K digestate of the fixed cervicovaginal cells in the liquid-based Papanicolaou (Pap) cytology specimens can be used as the sample for target DNA amplification without pre-PCR DNA extraction, purification and quantitation. The post-PCR products can be used directly as the sequencing templates without further purification or quantitation. By simplifying the frontend procedures for template preparation, the cost for screening these three founder mutations can be reduced to about US $200 per test when performed in conjunction with human papillomavirus (HPV) assays now routinely ordered for cervical cancer prevention. With this projected price structure, selective patients in a high-risk population can be tested and each provided with a set of DNA sequencing electropherograms to document the absence or presence of these founder mutations in her genome to help assess inherited susceptibility to breast and ovarian cancer in this era of precision molecular personalized medicine.

  14. Pío del Río Hortega and the discovery of the oligodendrocytes

    PubMed Central

    Pérez-Cerdá, Fernando; Sánchez-Gómez, María Victoria; Matute, Carlos

    2015-01-01

    Pío del Río Hortega (1882–1945) discovered microglia and oligodendrocytes (OLGs), and after Ramón y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolás Achúcarro from whom he learned the use of metallic impregnation techniques suitable to study non-neuronal cells. Later on, he joined Cajal’s laboratory. and Subsequently, he created his own group, where he continued to develop other innovative modifications of silver staining methods that revolutionized the study of glial cells a century ago. He was also interested in neuropathology and became a leading authority on Central Nervous System (CNS) tumors. In parallel to this clinical activity, del Río Hortega rendered the first systematic description of a major polymorphism present in a subtype of macroglial cells that he named as oligodendroglia and later OLGs. He established their ectodermal origin and suggested that they built the myelin sheath of CNS axons, just as Schwann cells did in the periphery. Notably, he also suggested the trophic role of OLGs for neuronal functionality, an idea that has been substantiated in the last few years. Del Río Hortega became internationally recognized and established an important neurohistological school with outstanding pupils from Spain and abroad, which nearly disappeared after his exile due to the Spanish civil war. Yet, the difficulty of metal impregnation methods and their variability in results, delayed for some decades the confirmation of his great insights into oligodendrocyte biology until the development of electron microscopy and immunohistochemistry. This review aims at summarizing the pioneer and essential contributions of del Río Hortega to the current knowledge of oligodendrocyte structure and function, and to provide a hint of the scientific personality of this extraordinary and insufficiently recognized man. PMID:26217196

  15. Segundo Catálogo Estelar del Hemisferio Sur con Astrolabio Fotoeléctrico PAII

    NASA Astrophysics Data System (ADS)

    Manrique, W. T.; Podestá, R. C.; Alonso, E.; Actis, E. V.; Pacheco, A. M.; Bustos, G.; Lizhi, L.; Zezhi, W.; Fanmiao, Z.; Hongqi, W.; Perdomo, R.

    Recordamos que entre el Observatorio Astronómico ``Félix Aguilar'', el Observatorio Astronómico de Beijing y el Observatorio Astronómico de La Plata, se ha convenido en desarrollar un Proyecto de Investigación conjunto, para la observación sistemática de estrellas en el Hemisferio Sur, con el objeto de la elaboración de un Catálogo Estelar Global utilizando un Astrolabio Fotoeléctrico PAII del Observatorio de Beijing, que ha sido usado con éxito en la República de China. En este trabajo se presenta el Segundo Catálogo Estelar del Hemisferio Sur, derivado de las observaciones realizadas con el PAII instalado en el OAFA, durante el períiodo Febrero de 1992 a Marzo de 1997. En este lapso se han observado mas de 400000 pasajes estelares, obteniéndose las correcciones Δ α y Δ δ de 5241 estrellas del FK4, FK5, FK5 Ext., SRS, CAMC y GC. Las precisiones medias son del orden de ± 3,2 ms en ascensión recta y ±0."057 en declinación. Rango de magnitudes : 2,0 a 11,5 Rango de declinaciones : -3o a -60o Epoca Media : 1994.9 Se analizan los residuos en función de la magnitud y tipo espectral, correcciones de grupo y frecuencia de distribución Δ α y Δ δ.

  16. Deep source model for Nevado del Ruiz Volcano, Colombia, constrained by interferometric synthetic aperture radar observations

    NASA Astrophysics Data System (ADS)

    Lundgren, P.; Samsonov, S. V.; López, C. M.; Ordoñez, M.

    2015-12-01

    Nevado del Ruiz (NRV) is part of a large volcano complex in the northern Andes of Colombia with a large glacier that erupted in 1985, generating a lahar killing over 23,000 people in the city of Armero and 2,000 people in the town of Chinchina. NRV is the most active volcano in Colombia and since 2012 has generated small eruptions, with no casualties, and constant gas and ash emissions. Interferometric synthetic aperture radar (InSAR) observations from ascending and descending track RADARSAT-2 data show a large (>20 km) wide inflation pattern apparently starting in late 2011 to early 2012 and continuing to the time of this study in early 2015 at a LOS rate of over 3-4 cm/yr (Fig. 1). Volcano pressure volume models for both a point source (Mogi) and a spheroidal (Yang) source find solutions over 14 km beneath the surface, or 10 km below sea level, and centered 10 km to the SW of Nevado del Ruiz volcano. The spheroidal source has a roughly horizontal long axis oriented parallel to the Santa Isabel - Nevado del Ruiz volcanic line and perpendicular to the ambient compressive stress direction. Its solution provides a statistically significant improvement in fit compared to the point source, though consideration of spatially correlated noise sources may diminish this significance. Stress change computations do not favor one model over the other but show that propagating dikes would become trapped in sills, leading to a more complex pathway to the surface and possibly explaining the significant lateral distance between the modeled sources and Nevado del Ruiz volcano.

  17. Pío del Río Hortega and the discovery of the oligodendrocytes.

    PubMed

    Pérez-Cerdá, Fernando; Sánchez-Gómez, María Victoria; Matute, Carlos

    2015-01-01

    Pío del Río Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramón y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolás Achúcarro from whom he learned the use of metallic impregnation techniques suitable to study non-neuronal cells. Later on, he joined Cajal's laboratory. and Subsequently, he created his own group, where he continued to develop other innovative modifications of silver staining methods that revolutionized the study of glial cells a century ago. He was also interested in neuropathology and became a leading authority on Central Nervous System (CNS) tumors. In parallel to this clinical activity, del Río Hortega rendered the first systematic description of a major polymorphism present in a subtype of macroglial cells that he named as oligodendroglia and later OLGs. He established their ectodermal origin and suggested that they built the myelin sheath of CNS axons, just as Schwann cells did in the periphery. Notably, he also suggested the trophic role of OLGs for neuronal functionality, an idea that has been substantiated in the last few years. Del Río Hortega became internationally recognized and established an important neurohistological school with outstanding pupils from Spain and abroad, which nearly disappeared after his exile due to the Spanish civil war. Yet, the difficulty of metal impregnation methods and their variability in results, delayed for some decades the confirmation of his great insights into oligodendrocyte biology until the development of electron microscopy and immunohistochemistry. This review aims at summarizing the pioneer and essential contributions of del Río Hortega to the current knowledge of oligodendrocyte structure and function, and to provide a hint of the scientific personality of this extraordinary and insufficiently recognized man. PMID:26217196

  18. Mach, Thirring & Lense, Gödel getting dizzy in space-time

    NASA Astrophysics Data System (ADS)

    Embacher, Franz

    2007-11-01

    Contrary to Newton's concept of inertia, general relativity predicts an influence of rotating matter on the structure of space and time. Anticipated by Ernst Mach, effects of this type have first been derived by Hans Thirring and Josef Lense. Almost ninety years later, we face their experimental verification. An even more dramatic scenario is provided by Kurt Gödel's cosmological model, in which nearby observers rotate with respect to each other and are free to travel to their own past.

  19. Juvenile rheumatoid arthritis and del(22q11) syndrome: a non-random association.

    PubMed Central

    Verloes, A; Curry, C; Jamar, M; Herens, C; O'Lague, P; Marks, J; Sarda, P; Blanchet, P

    1998-01-01

    Del(22q11) is a common microdeletion syndrome with an extremely variable phenotype. Besides classical manifestations, such as velocardiofacial (Shprintzen) or DiGeorge syndromes, del(22q11) syndrome may be associated with unusual but probably causally related anomalies that expand its phenotype and complicate its recognition. We report here three children with the deletion and a chronic, erosive polyarthritis resembling idiopathic cases of juvenile rheumatoid arthritis (JRA). Patient 1, born in 1983, initially presented with developmental delay, facial dysmorphism, velopharyngeal insufficiency, and severe gastro-oesophageal reflux requiring G tube feeding. From the age of 3 years, he developed JRA, which resulted in severe restrictive joint disease, osteopenia, and platyspondyly. Patient 2, born in 1976, had tetralogy of Fallot and peripheral pulmonary artery stenosis. She developed slowly, had mild dysmorphic facial features, an abnormal voice, and borderline intelligence. JRA was diagnosed at the age of 5 years. The disorder followed a subacute course, with relatively mild inflammatory phenomena, but an extremely severe skeletal involvement with major osteopenia, restrictive joint disease (bilateral hip replacement), and almost complete osteolysis of the carpal and tarsal bones with phalangeal synostoses, leading to major motor impairment and confinement to a wheelchair. Patient 3, born in 1990, has VSD, right embryo-toxon, bifid uvula, and facial dysmorphism. She developed JRA at the age of 1 year. She is not mentally retarded but has major speech delay secondary to congenital deafness inherited from her mother. In the three patients, a del(22q11) was shown by FISH analysis. These observations, and five other recently published cases, indicate that a JRA-like syndrome is a component of the del(22q11) spectrum. The deletion may be overlooked in those children with severe, chronic inflammatory disorder. Images PMID:9832043

  20. [Programme review of somatropin deficit in pediatrics at the Hospital Universitario Virgen del Rocío].

    PubMed

    Lavaredas, A; de la Puerta, R; Álvarez del Vayo, C

    2013-01-01

    Objetivo: Elaborar una revisión del programa de déficit de somatropina aplicado en pediatría en el Hospital Universitario Virgen del Rocío, utilizando dos grupos de pacientes, los diagnosticados con déficit de esta hormona y los nacidos pequeños para edad gestacional, con la intención de evaluar su efectividad en el primer año de tratamiento. Método: Realización de un estudio retrospectivo de la cohorte de pacientes en tratamiento con la hormona del crecimiento bajo los diagnósticos mencionados, con metodología observacional y transversal, a los cuales se aplicó un análisis estadístico con el programa Statistical Package for Social Sciences®. Resultados: Tras inicio del tratamiento la velocidad de crecimiento y la talla aumentaron y la edad ósea se aproximó a la edad cronológica. En los dos grupos tratados, en el primer año de tratamiento fueron los pacientes del sexo femenino con edad comprendida entre los 0 a 12 años con déficit de la hormona del crecimiento que respondieron mejor a la terapéutica establecida. Conclusiones: Pudimos observar que el tratamiento instituido se presentó altamente efectivo en ambos grupos de pacientes, permitiendo obtener un aumento favorable de estatura.

  1. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

    PubMed Central

    Van Goor, Fredrick; Hadida, Sabine; Grootenhuis, Peter D. J.; Burton, Bill; Stack, Jeffrey H.; Straley, Kimberly S.; Decker, Caroline J.; Miller, Mark; McCartney, Jason; Olson, Eric R.; Wine, Jeffrey J.; Frizzell, Ray A.; Ashlock, Melissa; Negulescu, Paul A.

    2011-01-01

    Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that impair the function of CFTR, an epithelial chloride channel required for proper function of the lung, pancreas, and other organs. Most patients with CF carry the F508del CFTR mutation, which causes defective CFTR protein folding and processing in the endoplasmic reticulum, resulting in minimal amounts of CFTR at the cell surface. One strategy to treat these patients is to correct the processing of F508del-CFTR with small molecules. Here we describe the in vitro pharmacology of VX-809, a CFTR corrector that was advanced into clinical development for the treatment of CF. In cultured human bronchial epithelial cells isolated from patients with CF homozygous for F508del, VX-809 improved F508del-CFTR processing in the endoplasmic reticulum and enhanced chloride secretion to approximately 14% of non-CF human bronchial epithelial cells (EC50, 81 ± 19 nM), a level associated with mild CF in patients with less disruptive CFTR mutations. F508del-CFTR corrected by VX-809 exhibited biochemical and functional characteristics similar to normal CFTR, including biochemical susceptibility to proteolysis, residence time in the plasma membrane, and single-channel open probability. VX-809 was more efficacious and selective for CFTR than previously reported CFTR correctors. VX-809 represents a class of CFTR corrector that specifically addresses the underlying processing defect in F508del-CFTR. PMID:21976485

  2. A Precambrian cratonic block in the west-central Chihuahua - The Sierra del Nido cratonic block

    SciTech Connect

    Goodell, P.C. . Dept. of Geological)

    1993-02-01

    Precambrian rocks in west-central Chihuahua have been recognized by Denison (1969) and Mauger et al. (1983), on the basis of radiometric dating. The rocks are rhyolite clasts, and an allucthonous block, respectively, however their source direction and vergence can be measured. They point back to and are on the edge of a large, uniform, negative Bouguer gravity anomaly, having values greater than 200 milligals. The isotopic geochemical character of several Tertiary felsic fields within this anomalous are has been determined, and initial strontium isotopic ratios are all greater than 0.7055. Outside the anomalous area these ratios are lower, and Basin and Range extension tectonism is more evident. It is proposed that a Precambrian cratonic block, the Sierra del Nido, is present in the crust in west-central Chihuahua. It is reasonable to propose that it was decreted from North America during a Precambrian extensional (1.1. By ) event, from somewhere along the Arizona Transition Zone-Texas Linament region. The Sierra del Nido Block is separated form the ATZ-TL by a region of disrupted craton and extended crust, the Basin and Range Province. Implications of the pressure of the Sierra del Nido Block on other regional tectonic events will be discussed.

  3. Proteolytic effect of Cynara cardunculus rennet for use in the elaboration of 'Torta del Casar' cheese.

    PubMed

    Ordiales, Elena; Benito, Maria José; Martin, Alberto; Fernández, Margarita; Hernández, Alejandro; de Guia Córdoba, Maria

    2013-11-01

    The purpose of this work was to analyse the influence of rennet from different Cynara cardunculus plants, selected for its clotting and proteolytic activity on caseins, on the characteristics of manufactured 'Torta del Casar' cheeses. After classifying the cardoon according to proteolytic activity into five groups of greater or lesser activity, 16 batches of cheeses were made with rennet derived from different wild cardoon plants. We observed a major development of the proteolysis during ripening leading to the generation of non-protein nitrogen compounds. Especially noteworthy was the relationship of amino acid nitrogen (AN) generation with rennet clotting activity after 24 h of maceration, and the fact that the production of biogenic amines was not related to the proteolytic activity of the rennet. The activities of the rennet observed 'in vitro' were also developed 'in vivo' in the cheeses, with the different rennets used affecting the final sensory characteristics of cheeses. The rennet with high clotting activity after 24 h of maceration was positively correlated with the creaminess, viscosity, and acceptability of the cheese. However, the high proteolytic activity rennet negatively influenced the acidity, bitterness, and creaminess parameters. Therefore the most appropriate cardoons for making this cheese are those with higher clotting activities and moderate proteolytic activities especially on β-casein. The use of controlled and characterised cardoons in the manufacturing process of Torta del Casar is fundamental to obtaining the homogeneous product demanded by the Torta del Casar Registry of the Protected Designation of Origin.

  4. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.

    PubMed

    Krönke, Jan; Fink, Emma C; Hollenbach, Paul W; MacBeth, Kyle J; Hurst, Slater N; Udeshi, Namrata D; Chamberlain, Philip P; Mani, D R; Man, Hon Wah; Gandhi, Anita K; Svinkina, Tanya; Schneider, Rebekka K; McConkey, Marie; Järås, Marcus; Griffiths, Elizabeth; Wetzler, Meir; Bullinger, Lars; Cathers, Brian E; Carr, Steven A; Chopra, Rajesh; Ebert, Benjamin L

    2015-07-01

    Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the E3 ubiquitin ligase CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)), resulting in CK1α degradation. CK1α is encoded by a gene within the common deleted region for del(5q) MDS and haploinsufficient expression sensitizes cells to lenalidomide therapy, providing a mechanistic basis for the therapeutic window of lenalidomide in del(5q) MDS. We found that mouse cells are resistant to lenalidomide but that changing a single amino acid in mouse Crbn to the corresponding human residue enables lenalidomide-dependent degradation of CK1α. We further demonstrate that minor side chain modifications in thalidomide and a novel analogue, CC-122, can modulate the spectrum of substrates targeted by CRL4(CRBN). These findings have implications for the clinical activity of lenalidomide and related compounds, and demonstrate the therapeutic potential of novel modulators of E3 ubiquitin ligases. PMID:26131937

  5. Pampa del Palo: an anomalous composite marine terrace on the uprising coast of southern Peru

    NASA Astrophysics Data System (ADS)

    Ortlieb, L.; Zazo, C.; Goy, J. L.; Dabrio, C.; Macharé, J.

    1996-11-01

    Quaternary sediments along the southern Perúvian coast occur as staircase terraces of coastal and shallow-marine deposits in response to continuous uplift related to the active boundary between the Nazca and South-American plates. However, near ILO (in the same coastal stretch) the emergent Pampa del Palo terrace consists of a relatively-thick, vertical stack of shallow-marine, coastal and lagoonal deposits that indicate a rather different geodynamic behaviour. Coastal deposits are correlatable with the successive marine highstands of isotopic stages 7 (?) and 5 (substages 5e and 5c). Combining aerial photo-interpretation, geomorphological mapping, sedimentological analysis, chronostratigraphical data, and structural observations, the Pampa del Palo feature is interpreted as a faulted block that moved independently of the remaining southern Peruvian coast and, for some time between the end of Middle Pleistocene (before ca. 220 ka) and the early Late Pleistocene (ca. 120 ka), it rose more slowly or was even down-faulted relative to the rest of the southern Peruvian margin. The independent block movements ceased after substage 5e, when the Pampa del Palo "terrace" was incorporated into the regional uplift of the area. Since ca. 100 ka, measured uplift rates in the Ilo area amounted up to {160 mm}/{10 3y } when the area has been affected by a few active, NE-SE trending faults only.

  6. [Seventy years of medicine in the Instituto Mexicano del Seguro Social].

    PubMed

    Fajardo-Ortiz, Guillermo

    2014-01-01

    The purpose of these lines is to remember and refer some of the historical landmarks in the evolution of the medical services of the Instituto Mexicano del Seguro Social (IMSS, according to its initials in Spanish) since it was founded, in 1943. We also want to bring to the reader's attention that the dimensions and impacts on health that IMSS has achieved, throughout its history, have strengthened the citizenship, as well as social sustainability. Also, those impacts have determined the creation and the reinforcement of human capital in México. Throughout this concise balance, all the controversy surrounding the foundation of the Institute is being recalled (the protest in the Mexico City Zócalo, or the attack to an hospital in San Ángel -a neighborhood located in the Southwest of Mexico City-), as well as the way the IMSS incorporated several words into the vocabulary of Mexicans. We also remember the previous antecedent of the Revista Médica del Instituto Mexicano del Seguro Social, as well as the Revista de Enfermería, and the emblematic Archives of Medical Research. The IMSS has 70 years of achievements, seven decades covered.

  7. Digitalización de diapositivas del Sol en H α

    NASA Astrophysics Data System (ADS)

    Missio, H.; Montenegro, C.; Montenegro, R.

    El objetivo de este trabajo ha sido el de obtener imágenes digitalizadas de las diapositivas tomadas del Sol en luz de hidrógeno de la línea correspondiente a Hα, y de esta manera llegar a convertir las mismas a un archivo digital para poder ser tratadas luego por computadora y poder contabilizar con exactitud, mediante un programa adecuado para tal fin, las zonas activas del Sol en la imagen digitalizada. En principio, para llegar a esto se pensó en la utilización de medios accesibles, y como detector se utilizó un fototransistor ubicado dentro de un soporte rectangular sobre dos ejes de desplazamiento X e Y. Se han obtenido con este procedimiento imágenes de buena calidad, construídas a partir de tres datos digitalizados en cada barrido que aportan la posición X e Y y la intensidad del pixel en ese punto indicada en 255 tonos de grises.

  8. Filaggrin mutations p.R501X and c.2282del4 in ichthyosis vulgaris.

    PubMed

    Gruber, Robert; Janecke, Andreas R; Fauth, Christine; Utermann, Gerd; Fritsch, Peter O; Schmuth, Matthias

    2007-02-01

    Ichthyosis vulgaris (IV) is the most common hereditary disorder of cornification in humans, characterized by generalized fine scaling of the skin, palmar hyperlinearity with or without keratosis pilaris and atopy. Recently, the molecular basis of IV was ascribed to loss-of-function mutations in the gene encoding filaggrin (FLG), namely p.R501X and c.2282del4. Homozygotes and compound heterozygotes were severely affected whereas heterozygotes showed mild disease or were asymptomatic, suggesting semidominant inheritance with incomplete penetrance in heterozygotes. We report the presence of FLG mutations in 15 out of 21 IV patients with a marked generalized scaling phenotype, including eight affected members of a four-generation family. In this group of patients not only homozygous and compound heterozygous, but also heterozygous patients for p.R501X and c.2282del4 display a pronounced phenotype, whereas in none of six individuals these two mutations were detectable despite decreased filaggrin expression on immunohistochemistry in two patients, indicating that other mutations in FLG and/or in other genes remain to be identified. In contrast, two additional p.R501X heterozygotes from the extended family are asymptomatic. In a control population from west-Austria a combined p.R501X and c.2282del4 carrier frequency of 6/110 (5.45%) was observed. We confirm that these FLG variants are common, but our results point to the existence of additional modifiers.

  9. Traffic circulation study and long-range plan for Del Rio. Interim research report

    SciTech Connect

    Weissmann, A.J.; Islam, R.

    1996-03-01

    A 1992 report to Congress, pursuant to Intermodal Surface Transportation Efficiency Act (ISTEA) sections 1089 and 6015, acknowledges that Texas serves a disproportionate share of the U.S.-Mexico international trade, and, accordingly, recommends the development of federal-aid program options to improve transportation infrastructure related to international trade. In order to take advantage of this recommendation, border states must monitor their transborder traffic demand and develop traffic circulation plans for their border cities. This report presents a 25-year traffic circulation plan for the City of Del Rio, Texas. The plan includes recommendations for increasing roadway capacity, adding left-turn lanes, building new routes to relieve congestion, and adding international thoroughfares. It also includes a comprehensive analysis of a transborder traffic in Del Rio, as well as of international thoroughfares between Cuidad Acuna and Del Rio. The recommendations take into account input from TxDOT personnel, City officials, border inspectors, international bridge managers, and several Mexican officials. The recommendations and schedules discussed in this report can assist TxDOT not only in planning land transport infrastructure, but also in alleviating problems associated with additional highway capacity, pavement rehabilitation, signalization, and right-of-way.

  10. Observaciones del disco solar y de una protuberancia quiescente en radiación ultravioleta

    NASA Astrophysics Data System (ADS)

    Cirigliano, D.; Vial, J.-C.; Rovira, M.

    Observaciones del disco solar y de una protuberancia quiescente en el rango de longitudes de onda ultravioleta fueron obtenidas con el instrumento CDS (Coronal Diagnostic Spectrograph) y SUMER (Solar Ultraviolet Measurements of emitted radiation) a bordo de la sonda SOHO. El propósito es investigar las velocidades macroscópicas de varias especies metálicas que se observan tanto en el disco solar como en el plasma de las protuberancias. Para calcular las velocidades del disco solar aplicamos una técnica mixta para modelar la distribución de estructuras en UV en el Sol quieto. Las velocidades macroscópicas en las protuberancias se calcularon a partir de los corrimientos Doppler en cada línea espectral y luego se tomaron las del disco solar como referencia. Obtuvimos valores absolutos para las velocidades macroscópicas entre 5 y 40 km/seg. También detectamos comportamientos diferentes en las velocidades de las protuberancias en el centro con respecto a los bordes.

  11. Heat flow and thermal processes in the Jornada delMuerto, New Mexico

    NASA Technical Reports Server (NTRS)

    Reiter, M.

    1985-01-01

    Most heat flow data in rifts are uncertain largely because of hydrologic disturbances in regions of extensive fracturing. Estimates of heat flow in deep petroleum tests within a large basin of the Rio Grande rift, which has suffered little syn-rift fracturing, may begin to provide clearer insight into the relationships between high heat flow and crustal thinning processes. The Jornada del Muerto is a large basin located in the Rio Grande rift of south central New Mexico. The region of interest within the Jornada del Muerto is centered about 30 km east of the town of Truth or Consequences, and is approximately 60 km north-south by 30 km east-west. High heat flows are estimated for the region. Values increase from about 90 mWm(-2) in the northern part of the study area to about 125 mWm(-2) in the southern part. These high heat flows are rather enigmatic because in the immediate vicinities of the sites there is little evidence of Cenozoic volcanism or syn-rift extensional tectonics. It is suggested that the geothermal anomaly in the southern Jornada del Muerto (approx. 125 to approx. 95 mWm(-2) results from some type of mass movement-heat transfer mechanism operating in the crust just below the elastic layer. This conclusion is consistent with the geologic and geophysical data which describe a thin crust, apparently devoid of features indicative of extensional-tectonics in the upper part of the lastic crust.

  12. Campano-Maastrichtian foraminifera from onshore sediments in the Rio del Rey Basin, Southwest Cameroon

    NASA Astrophysics Data System (ADS)

    Njoh, Oliver Anoh; Victor, Obiosio; Christopher, Agyingi

    2013-03-01

    Campanian-Maastrichtian marine sediments outcrop in five genetically linked sedimentary basins along the West African coast in the Gulf of Guinea, from the Douala Basin in Cameroon to the Anambra Basin in Nigeria. These sediments in the more centrally located Rio del Rey Basin have been the least studied. Therefore, the geologic history of this region has merely been speculative. The Rio del Rey Basin like the adjacent Niger Delta is producing hydrocarbon from the offshore Tertiary sedimentary interval in which all studies have been focused, neglecting the onshore Cretaceous sediments. Outcrops in the basin are rare, small and highly weathered. Samples from some of these sediments have yielded a few Planktonic and dominantly benthonic foraminiferal assemblages. The long-ranging heterohelix and hedbergellids characterized the planktics while the species Afrobolivina afra which is a well known diagnostic taxon for Campanian-Maastrichtian sediments in West African basins clearly dominate the benthic assemblage. Its occurrence in association with other Upper Cretaceous forms such as Bolivina explicata, Praebulimina exiqua, Gabonita lata, Ammobaculites coprolithiformis amongst others, formed the basis on which this age was assigned to the sediments sampled from the Rio del Rey Basin. Hence, this work has undoubtedly established the much needed link in this regional geologic history and correlates these sediments with the Logbaba and Nkporo Formations in the Douala Basin in Cameroon and the southeastern Nigerian Sedimentary Basins. Thus, these units were all deposited during this same geologic period and probably controlled by the same geologic event.

  13. Relevamiento total del hemisferio sur celeste en la frecuencia de 1420 MHz

    NASA Astrophysics Data System (ADS)

    Bava, J. A.; Colomb, F. R.; Hurrel, E.; Larrarte, J. J.; Sanz, A. J.; Testori, J. C.; Reich, P.; Reich, W.; Wielebinski, R.

    En el presente artículo se describe el relevamiento del cielo en el Hemisferio Sur Celeste en la frecuencia de 1420 MHz para declinaciones δ<= -19o realizado con la Antena II de 30 metros de diámetro del IAR. Este relevamiento posee igual sensibilidad (3xr.m.s=50 mK) que el realizado en el Hemisferio Norte con el radiotelescopio de 25 metros de Stockert de la Universidad de Bonn, operado por el Max-Planck Institute für Radioastronomie ( Reich W., 1982, A&ASS 48, 219; Reich P. and Reich W., 1986, A&ASS 63, 205). Con los datos obtenidos por ambos radiotelescopios se posee una base de datos de todo el cielo en esta frecuencia. En esta publicación presentamos los detalles del sistema receptor, técnicas de observación y reducción de datos, calibración y discusión de los errores en los resultados.

  14. Lenalidomide for myelodysplastic syndromes with del(5q): how long should it last?

    PubMed

    Vozella, Federico; Latagliata, Roberto; Carmosino, Ida; Volpicelli, Paola; Montagna, Chiara; Romano, Angela; Roberto, Amanda; Finsinger, Paola; Mancini, Marco; Breccia, Massimo; Oliva, Esther; Oliva, Esther

    2015-03-01

    Lenalidomide induces in patients with myelodysplastic syndrome (MDS) and del(5q) erythroid and cytogenetic response rates as high as 75% and 50%, respectively. It is still unclear, however, how long lenalidomide treatment should be continued and whether or not the drug could be interrupted. To assess the feasibility of lenalidomide discontinuation, we revised a cohort of 16 low-risk MDS patients with del(5q) treated at our institute in a phase II multicentric Italian study. Among the 12 responding patients, four discontinued lenalidomide while in complete response. All four patients needed during treatment a permanent lenalidomide reduction from 10 to 5 mg/day because of haematological toxicity (three patients) or grade 3 muscular and bone pain (one patient). At lenalidomide discontinuation after 16, 20, 27 and 20 months from the start, respectively, all four patients were in complete hematologic response and three forth in complete cytogenetic response. Three patients are still in response after 36, 30 and 20 months from lenalidomide discontinuation, respectively: The remaining patient relapsed after 20 months, and she is now receiving a new course of lenalidomide. In conclusion, long-lasting remissions are achievable in MDS patients with del(5q) in complete response after lenalidomide discontinuation. PMID:25950027

  15. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

    PubMed Central

    Hollenbach, Paul W.; MacBeth, Kyle J.; Hurst, Slater N.; Udeshi, Namrata D.; Chamberlain, Philip P.; Mani, D.R.; Man, Hon Wah; Gandhi, Anita K.; Svinkina, Tanya; Schneider, Rebekka K.; McConkey, Marie; Järås, Marcus; Griffiths, Elizabeth; Wetzler, Meir; Bullinger, Lars; Cathers, Brian E.; Carr, Steven A.; Chopra, Rajesh; Ebert, Benjamin L.

    2015-01-01

    Summary Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the CRL4CRBN E3 ubiquitin ligase, resulting in CK1α degradation. CK1α is encoded by a gene within the common deleted region for del(5q) MDS and haploinsufficient expression sensitizes cells to lenalidomide therapy, providing a mechanistic basis for lenalidomide's therapeutic window in del(5q) MDS. We found that mouse cells are resistant to lenalidomide but that changing a single amino acid in mouse Crbn to the corresponding human residue enables lenalidomide-dependent degradation of CK1α. We further demonstrate that minor side chain modifications in thalidomide and a novel analogue, CC-122, can modulate the spectrum of substrates targeted by CRL4CRBN. These findings have implications for the clinical activity of lenalidomide and related compounds and demonstrate the therapeutic potential of novel modulators of E3 ubiquitin ligases. PMID:26131937

  16. Variation in mangrove forest structure and sediment characteristics in Bocas del Toro, Panama

    USGS Publications Warehouse

    Lovelock, C.E.; Feller, Ilka C.; McKee, K.L.; Thompson, R.

    2005-01-01

    Mangrove forest structure and sediment characteristics were examined in the extensive mangroves of Bocas del Toro, Republic of Panama. Forest structure was characterized to determine if spatial vegetation patterns were repeated over the Bocas del Toro landscape. Using a series of permanent plots and transects we found that the forests of Bocas del Toro were dominated by Rhizophora mangle with very few individuals of Avicennia germinans and Laguncularia racemosa. Despite this low species diversity, there was large variation in forest structure and in edaphic conditions (salinity, concentration of available phosphorus, Eh and sulphide concentration). Aboveground biomass varied 20-fold, from 6.8 Mg ha-1 in dwarf forests to 194.3 Mg ha-1 in the forests fringing the land. But variation in forest structure was predictable across the intertidal zone. There was a strong tree height gradient from seaward fringe (mean tree height 3.9 m), decreasing in stature in the interior dwarf forests (mean tree height 0.7 m), and increasing in stature in forests adjacent to the terrestrial forest (mean tree height 4.1 m). The predictable variation in forest structure emerges due to the complex interactions among edaphic and plant factors. Identifying predictable patterns in forest structure will aid in scaling up the ecosystem services provided by mangrove forests in coastal landscapes. Copyright 2005 College of Arts and Sciences.

  17. Mitochondrial DNA diversity of feral pigs from Karukinka Natural Park, Tierra del Fuego Island, Chile.

    PubMed

    Aravena, P; Skewes, O; Gouin, N

    2015-04-28

    Control or eradication of exotic species is one of the greatest challenges facing biodiversity and ecosystem conservation. Domestic pigs (Sus scrofa domestica) were released and became feral in the southern region of Chilean Tierra del Fuego Island in the 1900s. Currently, they inhabit part of Karukinka Natural Park, an area of global conservation concern. To gain insight into the control of this invasive species, we analyzed genetic variation in the mitochondrial DNA control region to determine the origin and population subdivision of feral pigs in Tierra del Fuego. Sequences from a sample of 42 feral pigs, 10 domestic pigs from local farms, and references from other countries and commercial breeds revealed 2 highly differentiated populations, 1 in the western and the other in the eastern area of the park, each harboring a different haplotype, suggesting no connectivity between populations. Comparison of these haplotypes with reference sequences from other countries and commercial breeds indicated that feral pigs from Chilean Tierra del Fuego are of European origin, very likely from 2 separate introduction events. The haplotype found in the western feral population was also identified in domestic pigs from a farm. This raises concerns regarding the possible connectivity between stocks from local farms and the wild population. Based on these results, we recommend the development of strategies for controlling the population of this invasive species in Karukinka Natural Park.

  18. Morfología de la Coma del Cometa Hale - Bopp

    NASA Astrophysics Data System (ADS)

    Gil-Hutton, R.; Caballero, M.; Coldwell, G.; Cañada, M.; Godoy, G.; Trozzo, C.; Gómez, G.

    Para lograr comprender plenamente los procesos físicos que se desarrollan en los núcleos cometarios y obtener un modelo que explique, no sólo su actividad, sino también sus efectos sobre la coma, es necesario obtener información detallada para el mayor número de cometas posible, siendo las características más interesantes para estudiar la ubicación de las regiones activas, la presencia de jets, las tasas de producción de gas y polvo y la interacción de la coma con el viento solar. En la actualidad, con técnicas de procesamiento de imágenes y tecnología CCD se pueden obtener este tipo de datos para cometas que ingresan al sistema solar interior y estudiar, de esta manera, la morfología de sus comas, tratando de correlacionar la actividad detectada con algún modelo teórico. En este trabajo se presenta un estudio parcial de la actividad desarrollada por el cometa Hale-Bopp, y sus efectos sobre la morfología de su coma, desde agosto de 1995 hasta la fecha en base a imágenes adquiridas con el telescopio de 0.76 m. de la Estación Astronómica Dr. Carlos Ulrrico Cesco.

  19. Moléculas orgánicas obtenidas en simulaciones experimentales del medio interestelar.

    NASA Astrophysics Data System (ADS)

    Muñoz-Caro, Guillermo Manuel

    Las nubes moleculares son regiones de formación de estrellas, con temperaturas cinéticas entre 10-50 K y densidades de 103-106 átomos cm-3. Su materia está formada por gas y polvo interestelar. Estas partículas de polvo están cubiertas por una fina capa de hielo, de unos 0.01 μm, que contiene H2O y a menudo CO, CO2, CH3OH y NH3. El hielo es presumiblemente irradiado por fotones ultravioleta y rayos cósmicos en las zonas poco profundas de las nubes moleculares y las regiones circunestelares. En un sistema de vacío, P ˜ 10-7 mbar, simulamos la deposición de hielo a partir de 10 K y la irradiación ultravioleta por medio de una lámpara de descarga de hidrógeno activada con microondas. La evolución del hielo se observa por medio de un espectrómetro infrarrojo. De este modo es posible determinar la composición del hielo observado en el medio interestelar y predecir la presencia de moléculas aún no detectadas en el espacio, que han sido producto del procesamiento del hielo en nuestros experimentos. También es posible calentar el sistema hasta temperatura ambiente para sublimar el hielo depositado. Cuando el hielo ha sido previamente irradiado, se observa un residuo compuesto por moléculas orgánicas complejas, algunas prebióticas, como varios ácidos carboxílicos, aminas, amidas, ésteres y en menor proporción moléculas heterocíclicas y aminoácidos. Algunas de estas moléculas podrían detectarse en estado gaseoso por medio de observaciones milimétricas y de radio. También podrían estar presentes en el polvo cometario, cuyo análisis químico está planeado por las misiones Stardust y Rosetta. Mientras tanto, nuestro grupo está llevando a cabo el análisis de partículas de polvo interplanetario (IDPs), algunas de las cuales pueden ser de origen cometario. Al igual que ocurre con los productos obtenidos por irradiación del hielo en nuestros experimentos, algunas IDPs son ricas en material orgánico que contiene oxígeno.

  20. Detection and genetic analysis of the enteroaggregative Escherichia coli heat-stable enterotoxin (EAST1) gene in clinical isolates of enteropathogenic Escherichia coli (EPEC) strains

    PubMed Central

    2014-01-01

    Background The enteroaggregative E. coli heat-stable enterotoxin 1 (EAST1) encoded by astA gene has been found in enteropathogenic E. coli (EPEC) strains. However, it is not sufficient to simply probe strains with an astA gene probe due to the existence of astA mutants (type 1 and type 2 SHEAST) and EAST1 variants (EAST1 v1-4). In this study, 222 EPEC (70 typical and 152 atypical) isolates were tested for the presence of the astA gene sequence by PCR and sequencing. Results The astA gene was amplified from 54 strains, 11 typical and 43 atypical. Sequence analysis of the PCR products showed that 25 strains, 7 typical and 18 atypical, had an intact astA gene. A subgroup of 7 atypical strains had a variant type of the astA gene sequence, with four non-synonymous nucleotide substitutions. The remaining 22 strains had mutated astA gene with nucleotide deletions or substitutions in the first 8 codons. The RT-PCR results showed that the astA gene was transcribed only by the strains carrying either the intact or the variant type of the astA gene sequence. Southern blot analysis indicated that astA is located in EAF plasmid in typical strains, and in plasmids of similar size in atypical strains. Strains carrying intact astA genes were more frequently found in diarrheic children than in non-diarrheic children (p < 0.05). Conclusion In conclusion, our data suggest that the presence of an intact astA gene may represent an additional virulence determinant in both EPEC groups. PMID:24884767

  1. Sky Observation with the Use of the Software Stellarium for Teaching Astronomy in Classes of Youth and Adult Education. (Spanish Title: Observación del Cielo con la Utilización del Software Stellarium en Las Clases de Educación de Jóvenes y Adultos.) Observação do Céu Aliada À Utilização do Software Stellarium no Ensino de Astronomia em Turmas de Educação de Jovens e Adultos (EJA)

    NASA Astrophysics Data System (ADS)

    Oliveira Bernardes, Adriana

    2010-12-01

    The aim of this paper is to present a project developed through a partnership between the Astronomy Club of Itaocara Marcos Pontes (CAIMP) and Jaime de Souza Queiroz College, both located in the town of Itaocara, in the Northwest Fluminense, to disseminate Astronomy in adult education (Education for Youth and Adult). Given the interdisciplinary nature of Astronomy, we have developed this work to motivate the learning of this science by students in adult education, who attend the subjects Chemistry, Physics and Biology. Initially, we conducted a research in the school to assess the prior knowledge of Astronomy class of adult education, noting that there is little knowledge of basic concepts of the discipline. With these data, we were able to elaborate several activities that would enable a greater involvement of students with this science, performing in the school a work of improvement of scientific literacy, whose activities will be presented in this article. El objetivo de este artículo es presentar los resultados de un proyecto realizado por el Club de Astronomía de Itaocara "Marcos Pontes" (CAIMP), conjuntamente con el Colegio Estatal" Jaime de Souza Queiroz", ambos de la ciudad de Itaocara (Noroeste Fluminense - RJ, Brasil), para la difusión de la Astronomía entre los estudiantes, tanto adultos como adolescentes. Teniendo en cuenta la naturaleza interdisciplinaria de la Astronomía, se determinó motivar el estudio de esta ciencia en los estudiantes adultos de nivel secundario matriculados en las asignaturas de Química, Física y Biología. Como primer paso, se investigó el grado de conocimiento sobre astronomía del estudiante. Este estudio inicial mostró niveles de conocimiento muy bajos de los conceptos básicos de esta ciencia, muchos de los cuales deberían haber sido asimilados dentro del plan curricular del curso de Física. Este estudio previo permitió determinar las actividades adecuadas para promover un mayor envolvimiento de los estudiantes

  2. Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.

    PubMed

    De Stefano, Daniela; Villella, Valeria R; Esposito, Speranza; Tosco, Antonella; Sepe, Angela; De Gregorio, Fabiola; Salvadori, Laura; Grassia, Rosa; Leone, Carlo A; De Rosa, Giuseppe; Maiuri, Maria C; Pettoello-Mantovani, Massimo; Guido, Stefano; Bossi, Anna; Zolin, Anna; Venerando, Andrea; Pinna, Lorenzo A; Mehta, Anil; Bona, Gianni; Kroemer, Guido; Maiuri, Luigi; Raia, Valeria

    2014-01-01

    Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures rescue the functional expression of the most frequent pathogenic CFTR mutant, F508del, at the respiratory epithelial surface and reduce lung inflammation in Cftr(F508del) homozygous mice. Cysteamine, the reduced form of cystamine, is an FDA-approved drug. Here, we report that oral treatment with cysteamine greatly reduces the mortality rate and improves the phenotype of newborn mice bearing the F508del-CFTR mutation. Cysteamine was also able to increase the plasma membrane expression of the F508del-CFTR protein in nasal epithelial cells from F508del homozygous CF patients, and these effects persisted for 24 h after cysteamine withdrawal. Importantly, this cysteamine effect after washout was further sustained by the sequential administration of epigallocatechin gallate (EGCG), a green tea flavonoid, both in vivo, in mice, and in vitro, in primary epithelial cells from CF patients. In a pilot clinical trial involving 10 F508del-CFTR homozygous CF patients, the combination of cysteamine and EGCG restored BECN1, reduced SQSTM1 levels and improved CFTR function from nasal epithelial cells in vivo, correlating with a decrease of chloride concentrations in sweat, as well as with a reduction of the abundance of TNF/TNF-alpha (tumor necrosis factor) and CXCL8 (chemokine [C-X-C motif] ligand 8) transcripts in nasal brushing and TNF and CXCL8 protein levels in the sputum. Altogether, these results suggest that optimal schedules of cysteamine plus EGCG might be used for the treatment of CF caused by the F508del-CFTR mutation.

  3. Rescue of Murine F508del CFTR Activity in Native Intestine by Low Temperature and Proteasome Inhibitors

    PubMed Central

    Wilke, Martina; Bot, Alice; Jorna, Huub; Scholte, Bob J.; de Jonge, Hugo R.

    2012-01-01

    Most patients with Cystic Fibrosis (CF) carry at least one allele with the F508del mutation, resulting in a CFTR chloride channel protein with a processing, gating and stability defect, but with substantial residual activity when correctly sorted to the apical membranes of epithelial cells. New therapies are therefore aimed at improving the folding and trafficking of F508del CFTR, (CFTR correctors) or at enhancing the open probability of the CFTR chloride channel (CFTR potentiators). Preventing premature breakdown of F508del CFTR is an alternative or additional strategy, which is investigated in this study. We established an ex vivo assay for murine F508del CFTR rescue in native intestinal epithelium that can be used as a pre-clinical test for candidate therapeutics. Overnight incubation of muscle stripped ileum in modified William's E medium at low temperature (26°C), and 4 h or 6 h incubation at 37°C with different proteasome inhibitors (PI: ALLN, MG-132, epoxomicin, PS341/bortezomib) resulted in fifty to hundred percent respectively of the wild type CFTR mediated chloride secretion (forskolin induced short-circuit current). The functional rescue was accompanied by enhanced expression of the murine F508del CFTR protein at the apical surface of intestinal crypts and a gain in the amount of complex-glycosylated CFTR (band C) up to 20% of WT levels. Sustained rescue in the presence of brefeldin A shows the involvement of a post-Golgi compartment in murine F508del CFTR degradation, as was shown earlier for its human counterpart. Our data show that proteasome inhibitors are promising candidate compounds for improving rescue of human F508del CFTR function, in combination with available correctors and potentiators. PMID:23284872

  4. Análisis del espectro infrarrojo del polvo interestelar asociado con cúmulos globulares y de su evolución temporal

    NASA Astrophysics Data System (ADS)

    Pellizza, L. J.; Forte, J. C.; Carpintero, D.

    El trabajo que se presenta investiga la dinámica de las partículas de polvo interestelar eyectadas por estrellas gigantes rojas en un cúmulo globular utilizando simulaciones numéricas de su interacción con el campo gravitatorio y con la radiación electromagnética de las estrellas. Se pretende con ello determinar la distribución espacial de ese material como una función del tiempo en un sistema similar a NGC 104 (47 Tuc). A partir de la distribución espacial resultante se obtuvo el espectro infrarrojo integrado el cual sugiere que el máximo contraste con la radiación estelar ocurre en longitudes de onda cercanas a 300 μm y que decrece rápidamente hacia longitudes de onda menores, en las que suelen realizarse las observaciones.

  5. 500 days of Stromgren b, y and narrow-band [OIII], H α photometric evolution of gamma-ray Nova Del 2013 (=V339 Del)

    NASA Astrophysics Data System (ADS)

    Munari, Ulisse; Maitan, Alessandro; Moretti, Stefano; Tomaselli, Salvatore

    2015-10-01

    We present and discuss highly accurate photometry obtained through medium Stromgren y, b bands and narrow [OIII], Hα bands covering 500 days of the evolution of Nova Del 2013 since its maximum brightness. This is by far the most complete study of any nova observed in such photometric systems. The nova behavior in these photometric bands is very different from that observed with the more conventional broad bands like UBVRC IC or u‧g‧r‧i‧z‧ , providing unique information about extent and ionization of the ejecta, the onset of critical phases like the transition between optically thick and thin conditions, and re-ionization by the central super-soft X-ray source. The actual transmission profiles of the y, b , [OIII] and Hα photometric filters have been accurately measured at different epochs and different illumination angles, to evaluate in detail their performance under exact operating conditions. The extreme smoothness of both the Hα and [OIII] lightcurves argues for absence of large and abrupt discontinuities in the ejecta of Nova Del 2013. Should they exist, glitches in the lightcurves would have appeared when the ionization and/or recombination fronts overtook them. During the period of recorded very large variability (up to 100× over a single day) in the super-soft X-ray emission (from day +69 to +86 past V maximum), no glitch in excess of 1% was observed in the optical photometry, either in the continuum (Stromgren y) or in the lines ([OIII] and Hα filters), or in a combination of the two (Stromgren b, Johnson B and V). Considering that the recombination time scale in the ejecta was one week at that time, this excludes global changes of the white dwarf as the source of the X-ray variability and supports instead clumpy ejecta passing through the line of sight to us as its origin.

  6. The Torres del Paine intrusion as a model for a shallow magma chamber

    NASA Astrophysics Data System (ADS)

    Baumgartner, Lukas; Bodner, Robert; Leuthold, Julien; Muntener, Othmar; Putlitz, Benita; Vennemann, Torsten

    2014-05-01

    The shallow magmatic Torres del Paine Intrusive Complex (TPIC) belongs to a series of sub-volcanic and plutonic igneous bodies in Southern Chile and Argentina. This trench-parallel belt is located in a transitional position between the Patagonia Batholith in the West, and the alkaline Cenozoic plateau lavas in the East. While volumetrically small amounts of magmatism started around 28 my ago in the Torres del Paine area, and a second period occurred between 17-16 Ma, it peaked with the TPIC 12.59-12.43 Ma ago. The spectacular cliffs of the Torres del Paine National park provide a unique opportunity to study the evolution of a very shallow magma chamber and the interaction with its host rocks. Intrusion depth can be estimated based on contact metamorphic assemblages and granite solidus thermobarometry to 750±250 bars, corresponding to an intrusion depth of ca. 3km, ca. 500m above the base of the intrusion. Hornblende thermobarometry in mafic rocks agrees well with these estimates (Leuthold et al., 2014). The TPIC is composed of a granitic laccolith emplaced over 90ka (Michel et al., 2008) in 3 major, several 100m thick sheets, forming an overall thickness of nearly 2 km. Contacts are sharp between sheets, with the oldest sheet on the top and the youngest on the bottom (Michel et al., 2008). The granitic laccolith is under-plated by a ca. 400m thick mafic laccolith, built up over ca. 50ka (Leuthold et al. 2012), constructed from the bottom up. Granitic and mafic sheets are themselves composed of multiple metric to decametric pulses, mostly with ductile contacts between them, resulting in outcrop patterns resembling braided stream sediments. The contact of the TPIC with the Cretaceous flysch sediments document intrusion mechanism. Pre-existing sub-horizontal fold axes are rotated in the roof of the TPIC, clearly demonstrating ballooning of the roof; no ballooning was observed in the footwall of the intrusion. Extension during ballooning of the roof is indicated by

  7. Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation

    PubMed Central

    Tomati, Valeria; Sondo, Elvira; Armirotti, Andrea; Caci, Emanuela; Pesce, Emanuela; Marini, Monica; Gianotti, Ambra; Ju Jeon, Young; Cilli, Michele; Pistorio, Angela; Mastracci, Luca; Ravazzolo, Roberto; Scholte, Bob; Ronai, Ze’ev; Galietta, Luis J. V.; Pedemonte, Nicoletta

    2015-01-01

    Cystic fibrosis (CF) is caused by mutations in the CFTR chloride channel. Deletion of phenylalanine 508 (F508del), the most frequent CF mutation, impairs CFTR trafficking and gating. F508del-CFTR mistrafficking may be corrected by acting directly on mutant CFTR itself or by modulating expression/activity of CFTR-interacting proteins, that may thus represent potential drug targets. To evaluate possible candidates for F508del-CFTR rescue, we screened a siRNA library targeting known CFTR interactors. Our analysis identified RNF5 as a protein whose inhibition promoted significant F508del-CFTR rescue and displayed an additive effect with the investigational drug VX-809. Significantly, RNF5 loss in F508del-CFTR transgenic animals ameliorated intestinal malabsorption and concomitantly led to an increase in CFTR activity in intestinal epithelial cells. In addition, we found that RNF5 is differentially expressed in human bronchial epithelia from CF vs. control patients. Our results identify RNF5 as a target for therapeutic modalities to antagonize mutant CFTR proteins. PMID:26183966

  8. Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.

    PubMed

    Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M; McClean, Phillip E

    2014-01-01

    Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate.

  9. Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.

    PubMed Central

    Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M.; McClean, Phillip E.

    2013-01-01

    Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate. PMID:24860578

  10. miR-16 rescues F508del-CFTR function in native cystic fibrosis epithelial cells.

    PubMed

    Kumar, P; Bhattacharyya, S; Peters, K W; Glover, M L; Sen, A; Cox, R T; Kundu, S; Caohuy, H; Frizzell, R A; Pollard, H B; Biswas, R

    2015-11-01

    Cystic fibrosis (CF) is due to mutations in the CFTR gene, which prevents correct folding, trafficking and function of the mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein. The dysfunctional effect of CFTR mutations, principally the F508del-CFTR mutant, is further manifested by hypersecretion of the pro-inflammatory chemokine interleukin-8 into the airway lumen, which further contributes to morbidity and mortality. We have hypothesized that microRNA (miR)-based therapeutics could rescue the dysfunctional consequences of mutant CFTR. Here we report that a miR-16 mimic can effectively rescue F508del-CFTR protein function in airway cell lines and primary cultures, of differentiated human bronchial epithelia from F508del homozygotes, which express mutant CFTR endogenously. We also identify two other miRs, miR-1 and miR-302a, which are also active. Although miR-16 is expressed at basal comparable levels in CF and control cells, miR-1 and miR-302a are undetectable. When miR mimics are expressed in CF lung or pancreatic cells, the expression of the F508del-CFTR protein is significantly increased. Importantly, miR-16 promotes functional rescue of the cyclic AMP-activated apical F508del-CFTR chloride channel in primary lung epithelial cells from CF patients. We interpret these findings to suggest that these miRs may constitute novel targets for CF therapy.

  11. Hypothesizing an ancient Greek origin of the GJB2 35delG mutation: can science meet history?

    PubMed

    Kokotas, Haris; Grigoriadou, Maria; Villamar, Manuela; Giannoulia-Karantana, Aglaia; del Castillo, Ignacio; Petersen, Michael B

    2010-04-01

    One specific mutation of the GJB2 gene that encodes the connexin 26 protein, the 35delG mutation, has become a major interest among scientists who focus on the genetics of nonsyndromic hearing loss. The mutation accounts for the majority of GJB2 mutations detected in Caucasian populations and represents one of the most frequent disease mutations identified so far. The debate was so far between the arguments whether or not the 35delG mutation constitutes a mutational hot-spot or a founder effect; however, it was recently clarified that the latter seems the most likely. In an attempt to explore the origin and propagation of the 35delG mutation, several groups have reported the prevalence of the mutation and the carrier rates in different populations worldwide. It is now certain that the theory of a common founder prevails and that the highest carrier frequencies of the 35delG mutation are observed in southern European populations, giving rise to a discussion regarding the origin of the 35delG mutation. In this study, we discuss data previously published by our and other groups and also compare the haplotype distribution of the mutation in southern Europe, trying to understand the pathways of science and history and the conflict between them.

  12. Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.

    PubMed

    Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M; McClean, Phillip E

    2014-01-01

    Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate. PMID:24860578

  13. Espectroscopía integrada de cúmulos estelares de la Nube Mayor de Magallanes

    NASA Astrophysics Data System (ADS)

    Oddone, M. A.; Ahumada, A. V.; Clariá, J. J.

    2016-08-01

    As part of our systematic project of integrated spectroscopic observations of Magellanic Clouds star clusters, we present here the results for ten small angular diameter clusters of the Large Magellanic Cloud (LMC). Five of these clusters have been previously studied by our team. However, since we have been able to improve the integrated spectra signal-to-noise ratio, we can now determine the cluster basic parameters more accurately. We present reddenings and ages for these ten LMC clusters determined through different methods. The derived cluster ages range from 8 to 400 Myr. The spectra were obtained with the ``Jorge Sahade'' 2.15 m telescope at the Complejo Astronómico El Leoncito (CASLEO), using the REOSC spectrograph in the simple dispersion mode. Such spectra will be used to enlarge the existing library of LMC templates spectra.

  14. Youth Chance. A Program of the San Francisco Mayor's Office of Employment and Training.

    ERIC Educational Resources Information Center

    Lesser & Ogden Associates, San Francisco, CA.

    The San Francisco-based YMCA Youth Chance began in 1978 as a Youth Community Conservation and Improvement "sweat program"--a means of providing unemployed high school dropouts with CETA (Comprehensive Employment and Training Act)-funded jobs. Youth Chance continues to train males and females, 16-19 years of age, who meet CETA requirements.…

  15. Mayors' Report Card on Education: Informed and Engaged for Student Success

    ERIC Educational Resources Information Center

    George W. Bush Institute, Education Reform Initiative, 2015

    2015-01-01

    Making robust and reliable information about schools accessible is one of the most powerful ways to foster engagement and promote informed decisions that will shape our communities. Though education data is frequently collected and aggregated at the state level, data is rarely synthesized across cities. This report provides comparable information…

  16. The Significance for Education Reform of the New York City Mayoral Election

    ERIC Educational Resources Information Center

    Noguera, Pedro

    2014-01-01

    In this first 2014 issue of "Voices in Urban Education," Oona Chatterjee, the Annenberg Institute's associate director for New York City organizing, interviews Pedro Noguera, the Peter L. Agnew Professor of Education at New York University, a noted researcher and national commentator on topics such as urban school reform, conditions…

  17. Estructura de las burbujas en la region sureste de la Nube Mayor de Magallanes

    NASA Astrophysics Data System (ADS)

    Oddone, M. A.; Ambrocio-Cruz, S. P.; LeCoarer, E.; Goldes, G. V.

    In this work we present preliminary results obtained from the analysis carried out on the medium-size bubble structures located in the southeast region of the Large Magellanic Cloud (LMC). We determine the characteristic parameters of these structures (surface brightness; electronic density; emission measure; mass; luminosity; ambient density; age; energy; among others). This will allow us to discriminate which is the origin (stellar wind; supernova explosion; or other mechanisms) of the different bubbles that form the LMC9 supershell. Thus; we will try to determine whether the analyzed objects have kinematically some identity as a group; or they are relatively isolated objects on the diffuse background they belong to. FULL TEXT IN SPANISH

  18. Estudio de la evolucion quimica reciente de la Nube Mayor de Magallanes

    NASA Astrophysics Data System (ADS)

    Palma, T.; Clariá, J. J.; Geisler, D.; Ahumada, A. V.

    Based on Washington photometric observations carried out with the Victor Blanco 4m telescope at Cerro Tololo Inter-American Observatory (Chile); we examine the Large Magellanic Cloud (LMC) recent chemical evolution. As tracers of the LMC metallic enrichment; we observed and used 81 star clusters projected on different regions of the galaxy. Our sample includes 44 previously unstudied clusters. We find that the more metal-rich clusters are mainly located in the inner disc; while more metal-poor clusters are distributed throughout the entire disc. Intermediate-age clusters tend to be located at greater deprojected Galactocentric distances while the youngest ones are mainly found in the inner disc. These trends are maintained when the sample is complemented with others found in the literature and studied with the same technique. The resulting age-metallicity relationship appears to be independent of which LMC region is considered. FULL TEXT IN SPANISH

  19. The Press and Authority: Portrayals of a Coach and a Mayor. Journalism Monographs No. 50.

    ERIC Educational Resources Information Center

    Paletz, David L.; LaFiura, Dennis

    This monograph investigates the relationship between media and personal authority. Specifically, the nature and possible effects of coverage by the Durham, North Carolina, "Morning Herald" of Duke University's former basketball coach, Raymond C. (Bucky) Waters, are compared to its treatment of a more conventional political figure--Durham's former…

  20. Groundwater hydrogeochemistry of mayor ions in the Radovna River valley (NW Slovenia)

    NASA Astrophysics Data System (ADS)

    Torkar, Anja; Brenčič, Mihael; Vreča, Polona

    2013-04-01

    Chemical analysis of major elements was used to investigate the characteristics of various springs and surface water in the Radovna River valley. The valley is situated in the north-western part of Slovenia. It is 17-kilometre long Alpine river flowing between karstic plateaus of Pokljuka and Mežakla confluenting with Sava Dolinka River. Wider area of the valley is built up by Triassic limestone and dolomite. Quaternary alluvial and glacial sediments occur in the bottom of the valley and on the slopes of the plateaus. Water was sampled monthly from May 2005 till March 2007 at 10 locations along the valley. Locations are divided into: 5 springs, 3 surface water locations, 1 small lake and 1 artesian borehole. On site conductivity, pH and water temperature was measured and samples for chemical analyses were collected. Groundwater, spring water and surface water are related to carbonate rocks; therefore the pH of the samples is in range between 7.1 and 8.4. In most cases pH of river water is higher than that of groundwater and spring water. Conductivity of the water varied in the interval between 188 μS/cm and 374 μS/cm. Results of chemical analyses show that concentration of Ca2+ exceeds that of Mg2+ in all of the samples and Ca/Mg ratio varies between 2.6 and 16.8. The concentration of Na+ is lower than Mg2+, but always higher than that of K+. Predominant anion is the HCO3- and varies between 100 mg/l and 211 mg/l. Concentration of anions Cl-, NO3- and SO42- are low and range from 0.1 mg/l to 7.47 mg/l and between 0.62 mg/l and 12 mg/l for Cl- and SO42-, respectively. NO3- is in almost all of the samples below 1 mg/l. Water data shows that waters are alkaline and the dominant facies is Ca-Mg-HCO3-. Ion concentrations fluctuate seasonally and are related to changes in discharge. In winter and early spring, when the discharge is low, the ion concentrations are higher and in late spring and summer during snowmelt, when the discharge is higher, the ion concentration are lower. Generally, ion concentrations in the water are also increasing downstream from the main spring. Chemical analyses of the water samples reflect typical karst spring dynamics and dynamics of groundwater fluctuations in the alluvium. Along the course of the river, water flow is increasing due to great amount of groundwater drainage in to the stream, therefore the chemical concentrations are increasing downstream.

  1. Towards a systematic construction of realistic D-brane models on a del Pezzo singularity

    NASA Astrophysics Data System (ADS)

    Dolan, Matthew J.; Krippendorf, Sven; Quevedo, Fernando

    2011-10-01

    A systematic approach is followed in order to identify realistic D-brane models at toric del Pezzo singularities. Requiring quark and lepton spectrum and Yukawas from D3 branes and massless hypercharge, we are led to Pati-Salam extensions of the Standard Model. Hierarchies of masses, flavour mixings and control of couplings select higher order del Pezzo singularities, minimising the Higgs sector prefers toric del Pezzos with dP 3 providing the most successful compromise. Then a supersymmetric local string model is presented with the following properties at low energies: (i) the MSSM spectrum plus a local B - L gauge field or additional Higgs fields depending on the breaking pattern, (ii) a realistic hierarchy of quark and lepton masses and (iii) realistic flavour mixing between quark and lepton families with computable CKM and PMNS matrices, and CP violation consistent with observations. In this construction, kinetic terms are diagonal and under calculational control suppressing standard FCNC contributions. Proton decay operators of dimension 4, 5, 6 are suppressed, and gauge couplings can unify depending on the breaking scales from string scales at energies in the range 1012-1016 GeV, consistent with TeV soft-masses from moduli mediated supersymmetry breaking. The GUT scale model corresponds to D3 branes at dP 3 with two copies of the Pati-Salam gauge symmetry SU(4) × SU(2) R × SU(2) L . D-brane instantons generate a non-vanishing μ-term. Right handed sneutrinos can break the B - L symmetry and induce a see-saw mechanism of neutrino masses and R-parity violating operators with observable low-energy implications.

  2. F508del-CFTR rescue: a matter of cell stress response.

    PubMed

    Nieddu, Erika; Pollarolo, Benedetta; Merello, Luisa; Schenone, Silvia; Mazzei, Mauro

    2013-01-01

    Cystic fibrosis (CF) is a common inherited fatal disease affecting 70,000 people worldwide, with a median predicted age of survival of approximately 38 years. The deletion of Phenylalanine in position 508 of the Cystic Fibrosis Transmembrane conductance Regulator (F508del-CFTR) is the most common mutation in CF patients: the deleted protein, not properly folded, is degraded. To date no commercial drugs are available. Low temperature, some osmolytes and conditions able to induce heat shock protein 70 (Hsp70) expression and heat shock cognate 70 (Hsc70) inhibition result in F508del-CFTR rescue, hence restoring its physiological function: this review sheds light on the correlation between these several evidences. Interestingly, all these approaches have a role in the cell stress response (CSR), a set of cell reactions to stress. In addition, unpredictably, F508del-CFTR rescue has to be considered in the frame of CSR: entities that induce - or are induced during - the CSR are, in general, also able to correct trafficking defect of CFTR. Specifically, the low temperature induces, by definition, a CSR; osmolytes, such as glycerol and trimethylamine N-oxide (TMAO), are products of the CSR; pharmacological correctors, such as Matrine and 4-phenylbutirric acid (4PBA), down-regulate the constitutive Hsc70 in favor of an up-regulation of the inducible chaperone Hsp70, another component of the CSR. The identification of a common mechanism of action for different types of correctors could drive the discovery of new active molecules in CF, overcoming methods clinically inapplicable, such as the low temperature. PMID:23331026

  3. [Causes of maternal mortality in the Instituto Mexicano del Seguro Social, period 2009-2012].

    PubMed

    Ruíz-Rosas, Roberto Aguli; Cruz-Cruz, Polita Rocío

    2014-01-01

    Introducción: la razón de muerte materna (RMM) ha disminuido lentamente, no obstante que la OMS se propuso reducirla en un 75 % en el período de 1990 a 2015. Por esto es necesario continuar con el análisis de las causas para reforzar e innovar líneas de acción y así disminuir las muertes maternas en nuestro país. Métodos: estudio retrospectivo en el que se incluyeron casos de muerte materna que ocurrieron de 2009 a 2012, por causa directa e indirecta. La información se obtuvo del expediente de muerte materna, el cual es un documento oficial del IMSS. La definición de muerte materna utilizada fue la emitida por la OMS. Las muertes indirectas se agruparon según la décima revisión de la Clasificación Internacional de Enfermedades (CIE-10). Se utilizó estadística descriptiva. Resultados: la RMM en el IMSS ha disminuido en forma lenta pero constante, pues en el 2012 se obtuvo la RMM más baja en la institución (26.4). Sin embargo, la preeclampsia severa-eclampsia y la hemorragia obstétrica ocuparon el primero y segundo lugar. Como causa indirecta, las enfermedades del sistema cardiovascular, y las neoplasias malignas ocuparon los primeros lugares sin subestimar las cifras de las patologías respiratorias, digestivas y endocrinas. Conclusiones: es necesario proseguir con los esfuerzos para disminuir la RMM en todos los niveles de atención médica. Es prioritario continuar con la educación y consejería preconcepcional a mujeres en edad fértil y fortalecer las acciones en la planificación familiar.

  4. Biophysical characterisation of calumenin as a charged F508del-CFTR folding modulator.

    PubMed

    Tripathi, Rashmi; Benz, Nathalie; Culleton, Bridget; Trouvé, Pascal; Férec, Claude

    2014-01-01

    The cystic fibrosis transmembrane regulator (CFTR) is a cyclic-AMP dependent chloride channel expressed at the apical surface of epithelial cells lining various organs such as the respiratory tract. Defective processing and functioning of this protein caused by mutations in the CFTR gene results in loss of ionic balance, defective mucus clearance, increased proliferation of biofilms and inflammation of human airways observed in cystic fibrosis (CF) patients. The process by which CFTR folds and matures under the influence of various chaperones in the secretory pathway remains incompletely understood. Recently, calumenin, a secretory protein, belonging to the CREC family of low affinity calcium binding proteins has been identified as a putative CFTR chaperone whose biophysical properties and functions remain uncharacterized. We compared hydropathy, instability, charge, unfoldability, disorder and aggregation propensity of calumenin and other CREC family members with CFTR associated chaperones and calcium binding proteins, wild-type and mutant CFTR proteins and intrinsically disordered proteins (IDPs). We observed that calumenin, along with other CREC proteins, was significantly more charged and less folded compared to CFTR associated chaperones. Moreover like IDPs, calumenin and other CREC proteins were found to be less hydrophobic and aggregation prone. Phylogenetic analysis revealed a close link between calumenin and other CREC proteins indicating how evolution might have shaped their similar biophysical properties. Experimentally, calumenin was observed to significantly reduce F508del-CFTR aggregation in a manner similar to AavLEA1, a well-characterized IDP. Fluorescence microscopy based imaging analysis also revealed altered trafficking of calumenin in bronchial cells expressing F508del-CFTR, indicating its direct role in the pathophysiology of CF. In conclusion, calumenin is characterized as a charged protein exhibiting close similarity with IDPs and is

  5. Oxygen isotope evidence for submarine hydrothermal alteration of the Del Puerto ophiolite, California

    USGS Publications Warehouse

    Schiffman, P.; Williams, A.E.; Evarts, R.C.

    1984-01-01

    The oxygen isotope compositions and metamorphic mineral assemblages of hydrothermally altered rocks from the Del Puerto ophiolite and overlying volcaniclastic sedimentary rocks at the base of the Great Valley sequence indicate that their alteration occurred in a submarine hydrothermal system. Whole rock ??18O compositions decrease progressively down section (with increasing metamorphic grade): +22.4??? (SMOW) to +13.8 for zeolite-bearing volcaniclastic sedimentary rocks overlying the ophiolite; +19.6 to +11.6 for pumpellyite-bearing metavolcanic rocks in the upper part of the ophiolite's volcanic member; +12.3 to +8.1 for epidote-bearing metavolcanic rocks in the lower part of the volcanic member; +8.5 to +5.7 for greenschist facies rocks from the ophiolite's plutonic member; +7.6 to +5.8 for amphibolite facies or unmetamorphosed rocks from the plutonic member. Modelling of fluid-rock interaction in the Del Puerto ophiolite indicates that the observed pattern of upward enrichment in whole rock ??18O can be best explained by isotopic exchange with discharging 18O-shifted seawater at fluid/rock mass ratios near 2 and temperatures below 500??C. 18O-depleted plutonic rocks necessarily produced during hydrothermal circulation were later removed as a result of tectonism. Submarine weathering and later burial metamorphism at the base of the Great Valley sequence cannot by itself have produced the zonation of hydrothermal minerals and the corresponding variations in oxygen isotope compositions. The pervasive zeolite and prehnite-pumpellyite facies mineral assemblages found in the Del Puerto ophiolite may reflect its origin near an island arc rather than deep ocean spreading center. ?? 1984.

  6. Biophysical characterisation of calumenin as a charged F508del-CFTR folding modulator.

    PubMed

    Tripathi, Rashmi; Benz, Nathalie; Culleton, Bridget; Trouvé, Pascal; Férec, Claude

    2014-01-01

    The cystic fibrosis transmembrane regulator (CFTR) is a cyclic-AMP dependent chloride channel expressed at the apical surface of epithelial cells lining various organs such as the respiratory tract. Defective processing and functioning of this protein caused by mutations in the CFTR gene results in loss of ionic balance, defective mucus clearance, increased proliferation of biofilms and inflammation of human airways observed in cystic fibrosis (CF) patients. The process by which CFTR folds and matures under the influence of various chaperones in the secretory pathway remains incompletely understood. Recently, calumenin, a secretory protein, belonging to the CREC family of low affinity calcium binding proteins has been identified as a putative CFTR chaperone whose biophysical properties and functions remain uncharacterized. We compared hydropathy, instability, charge, unfoldability, disorder and aggregation propensity of calumenin and other CREC family members with CFTR associated chaperones and calcium binding proteins, wild-type and mutant CFTR proteins and intrinsically disordered proteins (IDPs). We observed that calumenin, along with other CREC proteins, was significantly more charged and less folded compared to CFTR associated chaperones. Moreover like IDPs, calumenin and other CREC proteins were found to be less hydrophobic and aggregation prone. Phylogenetic analysis revealed a close link between calumenin and other CREC proteins indicating how evolution might have shaped their similar biophysical properties. Experimentally, calumenin was observed to significantly reduce F508del-CFTR aggregation in a manner similar to AavLEA1, a well-characterized IDP. Fluorescence microscopy based imaging analysis also revealed altered trafficking of calumenin in bronchial cells expressing F508del-CFTR, indicating its direct role in the pathophysiology of CF. In conclusion, calumenin is characterized as a charged protein exhibiting close similarity with IDPs and is

  7. F508del-CFTR rescue: a matter of cell stress response.

    PubMed

    Nieddu, Erika; Pollarolo, Benedetta; Merello, Luisa; Schenone, Silvia; Mazzei, Mauro

    2013-01-01

    Cystic fibrosis (CF) is a common inherited fatal disease affecting 70,000 people worldwide, with a median predicted age of survival of approximately 38 years. The deletion of Phenylalanine in position 508 of the Cystic Fibrosis Transmembrane conductance Regulator (F508del-CFTR) is the most common mutation in CF patients: the deleted protein, not properly folded, is degraded. To date no commercial drugs are available. Low temperature, some osmolytes and conditions able to induce heat shock protein 70 (Hsp70) expression and heat shock cognate 70 (Hsc70) inhibition result in F508del-CFTR rescue, hence restoring its physiological function: this review sheds light on the correlation between these several evidences. Interestingly, all these approaches have a role in the cell stress response (CSR), a set of cell reactions to stress. In addition, unpredictably, F508del-CFTR rescue has to be considered in the frame of CSR: entities that induce - or are induced during - the CSR are, in general, also able to correct trafficking defect of CFTR. Specifically, the low temperature induces, by definition, a CSR; osmolytes, such as glycerol and trimethylamine N-oxide (TMAO), are products of the CSR; pharmacological correctors, such as Matrine and 4-phenylbutirric acid (4PBA), down-regulate the constitutive Hsc70 in favor of an up-regulation of the inducible chaperone Hsp70, another component of the CSR. The identification of a common mechanism of action for different types of correctors could drive the discovery of new active molecules in CF, overcoming methods clinically inapplicable, such as the low temperature.

  8. Petroleum geology of the deltaic sequence, Rio Del Rey basin, offshore Cameroon

    SciTech Connect

    Coughlin, R.M.; Bement, W.O.; Maloney, W.V. )

    1993-09-01

    The Rio Del Rey Basin of offshore Cameroon comprises the easternmost portion of the Niger delta complex. In the delta flank setting, the overall package is thinner and stratigraphic correlation simpler than in the depocenter to the west so the distribution of reservoirs and seals is well defined. Productive reservoirs are shallow, typically less than 2000 m, and mostly hydropressured to slightly overpressured. Reservoir properties generally are excellent and seismic bright-spot technology has played a major role in exploration and development efforts. Rio Del Rey is characterized by three main structural styles from north to south: (1) detachment-based growth faults, (2) highly faulted, mobile shale cored domes and ridges, and (3) toe thrusts and folds. Virtually all individual traps are fault dependent and lack of sufficient internal seals in sand-rich wave-dominated deltaic sequences can limit the objective window. Most fields are downthrown fault traps in which hanging-wall reservoirs are effectively sealed against older prodelta and marine shales. All large oil fields are located in the dome and ridge province and are potential analogs for similar structures now being explored on the upper slope off Nigeria. The best quality source rocks identified thus far are Paleocene to Eocene marine shales. Oil vs. gas distribution in the basin is a function of variations in the kerogen type, organic richness, and maturity of these source rocks. A significant quantity of the gas found to date in Rio Del Rey is biogenic in origin. The Cameroon charge model may aid in better understanding hydrocarbon distribution on offshore Nigeria, where the Miocene deltaic section is much thicker and potential Paleocene-Eocene source rocks likely are unpenetrated. The shallow deltaic play in Cameroon is relatively mature. Future exploration likely will focus on identifying deeper, nonbright-spot-supported opportunities including potential stratigraphic traps.

  9. Multimodal Assessment of Protein Functional Deficiency Supports Pathogenicity of BRCA1 p.V1688del

    PubMed Central

    De Nicolo, Arcangela; Parisini, Emilio; Zhong, Quan; Palma, Maurizia Dalla; Stoeckert, Kathryn A.; Domchek, Susan M.; Nathanson, Katherine L.; Caligo, Maria A.; Vidal, Marc; Cusick, Michael E.; Garber, Judy E.

    2009-01-01

    Unequivocal discrimination between neutral variants and deleterious mutations is crucial for appropriate counseling of individuals with a BRCA1 or BRCA2 sequence change. An increasing number of variants of uncertain significance (VUSs) are being identified, whose unclassified biological effect poses clinical concerns. A multifactorial likelihood-based approach recently suggested disease causality for BRCA1 p.V1688del, a VUS recurrent in Italian breast/ovarian cancer families. Whether and how this single amino acid deletion in the BRCA1 BRCT domain affects the function of the mutant protein (ΔValBRCA1) has not been elucidated. We undertook comprehensive functional characterization of ΔValBRCA1, comprising comparative structural modeling, analysis of protein stability and associations, and analysis of DNA repair function. Our model predicted BRCT domain destabilization and folding disruption caused by BRCA1 p.V1688del. Consistently, the recombinant ΔValBRCA1 was less stable than wtBRCA1 and, unlike the latter, failed to associate with BRIP1, CtIP, and Rap80, and to re-localize to sites of DNA damage. Yeast two-hybrid analysis revealed a compromised interaction with FHL2 and with KPNA2, which is likely responsible for improper subcellular localization of ΔValBRCA1. In addition, we found four new breast/ovarian cancer families of Italian ancestry who carried this sequence alteration. These results provide the first evidence of the effect of BRCA1 p.V1688del on protein stability and function, supporting the view that it is a deleterious mutation. Multimodal analyses like ours could advance understanding of tumor suppression by BRCA1, and ultimately contribute to developing efficient strategies for screening and characterization of VUSs. PMID:19706752

  10. Early neogene history of the central American arc from Bocas del Toro, western Panama

    USGS Publications Warehouse

    Coates, A.G.; Aubry, M.-P.; Berggren, W.A.; Collins, Luke S.; Kunk, M.

    2003-01-01

    A newly discovered sequence of lower to middle Miocene rocks from the eastern Bocas del Toro archipelago, western Panama, reveals the timing and environment of the earliest stages in the rise of the Isthmus of Panama in this region. Two new formations, the Punta Alegre Formation (lower Miocene, Aquitanian to Burdigalian) and the Valiente Formation (middle Miocene, Langhian to Serravallian), are here named and formally described. The Punta Alegre Formation contains a diagnostic microfauna of benthic and planktic foraminifera and calcareous nannofossils that indicate deposition in a 2000-m-deep pre-isthmian neotropical ocean from as old as 21.5-18.3 Ma. Its lithology varies from silty mudstone to muddy foraminiferal ooze with rare thin microturbidite layers near the top. The Valiente Formation, which ranges in age from 16.4 to ca. 12.0 Ma, lies with slight angular unconformity on the Punta Alegre Formation and consists of five lithofacies: (1) columnar basalt and flow breccia, (2) pyroclastic deposits, (3) coarse-grained volcaniclastic deposits, (4) coral-reef limestone with diverse large coral colonies, and (5) marine debris-flow deposits and microturbidities. These lithofacies are interpreted to indicate that after ca. 16 Ma a volcanic arc developed in the region of Bocas del Toro and that by ca. 12 Ma an extensively emergent archipelago of volcanic islands had formed. 39Ar/40Ar dating of basalt flows associated with the fossiliferous sedimentary rocks in the upper part of the Valiente Formation strongly confirms the ages derived from planktic foraminifera and nannofossils. Paleobathymetric analysis of the two new formations in the Valiente Peninsula and Popa Island, in the Bocas del Toro archipelago, shows a general shallowing from lower- through upper-bathyal to upper-neritic and emergent laharic and fluviatile deposits from ca. 19 to 12 Ma. The overlying nonconformable Bocas del Toro Group contains a lower transgressive sequence ranging from basal nearshore

  11. Stratigraphic context and direct dating of the Neandertal mandible from Cova del Gegant (Sitges, Barcelona).

    PubMed

    Daura, J; Sanz, M; Pike, A W G; Subirà, M E; Fornós, J J; Fullola, J M; Julià, R; Zilhão, J

    2010-07-01

    Stratigraphic study of the Cova del Gegant's sedimentary fill revealed different cycles of accumulation of typical interior cave and delta facies. A precise chronology for these deposits, the faunal remains and stone tools contained therein was obtained by radiocarbon, U-Th and OSL. Our results indicate that the Upper Pleistocene archaeological sequence dates between 49.3 +/- 1.8 ka BP, the U-Th age of the overlying flowstone, and 60.0 +/- 3.9 ka BP, the OSL age of the basal deposits. We have also directly dated the site's Neandertal mandible to 52.3 +/- 2.3 ka by U-Th.

  12. Uranium series dating of human skeletal remains from the del mar and sunnyvale sites, california.

    PubMed

    Bischoff, J L; Rosenbauer, R J

    1981-08-28

    Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8,300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low.

  13. Uranium series dating of human skeletal remains from the del mar and sunnyvale sites, california.

    PubMed

    Bischoff, J L; Rosenbauer, R J

    1981-08-28

    Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8,300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low. PMID:17789030

  14. Mortality according to age and burned body surface in the Virgen del Rocio University Hospital.

    PubMed

    Gómez-Cía, T; Mallén, J; Márquez, T; Portela, C; Lopez, I

    1999-06-01

    The application of updated clinical protocols for the treatment of burned patients is showing very good results. The mortality curves according to age and the percentage of burned body surface could be of great use for the comparison of clinical results between different burns units. The probability of survival in 1000 consecutive patients admitted to the Burns Unit of the Virgen del Rocio University Hospital between July, 1993 and August, 1997, is compared, by graphic analysis, with the mortality curves of other centers, obtaining similar results. We conclude that the results of medical attendance in our unit are in line with those considered as a reference.

  15. Eruption of the nevado del ruiz volcano, Colombia, on 13 november 1985: tephra fall and lahars.

    PubMed

    Naranjo, J L; Sigurdsson, H; Carey, S N; Fritz, W

    1986-08-29

    A small Plinian eruption of the Nevado del Ruiz volcano in Colombia ejected 3.5 x 10(10) kilograms of mixed dacite and andesite tephra on 13 November 1985, with a maximum column height of 31 kilometers above sea level. Small pyroclastic flows and surges, generated during the initial stage of the eruption, caused surface melting of approximately 10% of the volcano's ice cap, leading to meltwater floods. The erosive floods incorporated soils and loose sediments from the volcano's flanks and developed into lahars, which claimed at least 25,000 lives.

  16. Descripción del coronógrafo a ser instalado en Argentina (MICA)

    NASA Astrophysics Data System (ADS)

    Stenborg, G.; Francile, C.; Schwenn, R.; Epple, A.; Rovira, M.

    El ``Coronógrafo de espejo para Argentina'' es un telescopio solar terrestre a ser colocado en el Observatorio Astronómico Félix Aguilar (El Leoncito), antes de finalizar 1996, como parte de un programa de ciencia bilateral entre Alemania y Argentina. Eclipses fotográficos de alta resolución han revelado que la corona solar es altamente estructurada y variable. De hecho, está contínuamente deformada y moldeada por los movimientos convectivos de los extremos de los arcos magnéticos en la fotosfera, estando, en muchas oportunidades, afectada por explosivas liberaciones de energía. MICA, en conjunción con otros telescopios solares espaciales y terrestres, tratará de contribuir al entendimiento de cuestiones fundamentales de la física solar. Entre ellas: cómo la corona está siendo calentada, dónde y cómo el viento solar es acelerado, qué causa los transitorios coronales, etc. Para ello investigará la distribución de los parámetros del plasma y su evolución con el tiempo, la estructura espacial de la corona en fina y gran escala, procesos que ocurren en los transitorios coronales y factores que los disparan, etc. Para responder a estas cuestiones MICA observará la atmósfera solar por sobre el limbo entre 1.1 y 2 radios solares aproximadamente, usando un nuevo tipo de sistema coronográfico que permite suprimir el brillo del disco solar suficientemente bien, tomando las imágenes con una cámara CCD de 1024x1024 pixels, codificada en 12 bits, pudiendo el mismo ser operado en forma remota. En la presente exposición describiremos las características del instrumento, cómo será controlado y qué esperamos observar basados en las imágenes obtenidas por los telescopios de similares características LASCO C1 a bordo del SOHO y PICO (ubicado en el Observatorio de Pic du Midi, Francia).

  17. Eruption of the nevado del ruiz volcano, Colombia, on 13 november 1985: tephra fall and lahars.

    PubMed

    Naranjo, J L; Sigurdsson, H; Carey, S N; Fritz, W

    1986-08-29

    A small Plinian eruption of the Nevado del Ruiz volcano in Colombia ejected 3.5 x 10(10) kilograms of mixed dacite and andesite tephra on 13 November 1985, with a maximum column height of 31 kilometers above sea level. Small pyroclastic flows and surges, generated during the initial stage of the eruption, caused surface melting of approximately 10% of the volcano's ice cap, leading to meltwater floods. The erosive floods incorporated soils and loose sediments from the volcano's flanks and developed into lahars, which claimed at least 25,000 lives. PMID:17732038

  18. Holocene paleoclimate characterization in Lago Fagnano (Tierra del Fuego) using sedimentary, physical and geochemical proxies

    NASA Astrophysics Data System (ADS)

    Vizcaino Marti, A.; Dunbar, R. B.; Wahl, D.; Moy, C. M.; Mucciarone, D. A.; Anderson, L.; Guilderson, T. P.

    2010-12-01

    Tierra del Fuego is the world's southernmost landmass outside of Antarctica. Two features of ocean circulation control the climate of Tierra del Fuego: the Southern Ocean circumpolar flow and the South Pacific Gyre. Together with Patagonia, Tierra del Fuego is the only terrestrial region directly influenced by the southern hemisphere westerly winds. This region is also a tectonically active area affected by volcanic and seismic activity related to South American and Scotia-Antarctic plate boundaries. Accommodated along the Magallanes-Fagnano fault system, as part of the plate boundary, the Lago Fagnano is the largest lake in Tierra del Fuego. This E-W trending lake is 100 km long and 5-15 km wide. Our investigations were carried out on the upper 4 meters of an 8.4 m long piston core obtained at 69 m water depth in Bahía Grande (LF06-PC8); a southwestern lake sub-basin separated from the main lake by a shallow sill. Our studies are based on the integration of sediment description, physical properties, pollen, and geochemical analyses including C and N isotopes (1cm interval) and XRF scan (1mm interval). The age model for the core is based on radiocarbon ages and tephrochronology. Additionally, a 800 km long grid of high resolution seismic profiles support the sedimentary analyses and allow the correlation with other cores from within the lake basin. LF06-PC8 yields continuous and high accumulation-rate sedimentary sections for Lago Fagnano. The presented sediment record corresponds to a laminated hemipelagite with presence of a single but complex mass transport deposit interval. An accurate sedimentological interpretation of the core together with the radiocarbon ages and tephra dates allow to identify and characterize the main sedimentary processes occurring in the lake over the last 8 kyr. In addition, proxy data (C and N isotopes and XRF scan data) from the laminated hemipelagic interval provide a reliable record of past variability in the westerly wind field as

  19. Uranium series dating of human skeletal remains from the Del Mar and Sunnyvale sites, California

    SciTech Connect

    Bischoff, J.L.; Rosenbauer, R.J.

    1981-08-28

    Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low.

  20. Anomalous ocean load tide signal observed in lake-level variations in Tierra del Fuego

    NASA Astrophysics Data System (ADS)

    Richter, A.; Hormaechea, J. L.; Dietrich, R.; Perdomo, R.; Fritsche, M.; Del Cogliano, D.; Liebsch, G.; Mendoza, L.

    2009-03-01

    We demonstrate the application of a 100 km long lake as a sensor for studying the tidal effects on Tierra del Fuego main island. The lake-level variations observed in Lago Fagnano reflect both the direct response to the tidal potential and the indirect effect of the ocean tidal loading. Modeling both contributions explains the observed tidal signal in the lake to about 70%. Underestimated model load tide amplitudes are found to be probably responsible for the remaining difference. We interpret this discrepancy as a hint for regional elastic lithosphere properties differing substantially from those represented by currently available global models.

  1. Pliocene Transgression in the Western Mediterranean Sea: Strontium Isotopes from Cuevas Del Almanzora (Se Spain)

    NASA Astrophysics Data System (ADS)

    Müller, Daniel W.

    1993-02-01

    The deposition of marine sediments in the deep Mediterranean basins following the Messinian salinity crisis ("Zanclean Deluge") began at 4.9 Ma and continued until normal marine conditions prevailed at 4.6 Ma. The Betic Strait of southeast Spain, the Rif Strait of northern Morocco, and the Strait of Gibraltar have been postulated as possible entry ways for the marine waters into the Mediterranean. Two possible explanations have been offered for the timing of the deposition of marine hemipelagic marls in the Vera Basin (Cuevas del Almanzora section) within the Betic Strait: (1) early Pliocene, representing the "Zanclean Deluge" (Cita et al., 1980), (2) Messinian (˜5.7 Ma), representing the last marine stage before the Messinian salinity crisis (Benson and Rakic-El Bied, 1991; Benson et al., 1991). The strontium isotopic ratio on mixed assemblages of foraminifers from these marine marls was determined in order to assess their ages. The average 87Sr/86Sr (0.709033±24) of the seven measured samples is, compared to the base of the Miocene/Pliocene boundary stratotype at Capo Rossello, Sicily, higher by 38 × 10-6 and yields an age of 4.6±0.5 Ma when compared to the established open ocean Sr seawater curve. The determined age indicates that (1) the first 3.6 m of marine deposits of the Cuevas del Almanzora section sensu Cita et al. (1980) including the passage zone are Pliocene, (2) the earliest marine Pliocene might not be represented at Cuevas del Almanzora indicating that this marginal basin at the edge of the Mediterranean Sea, yet within the former Betic Strait, was filled progressively by a marine transgression originating from the Mediterranean Sea around 4.6 Ma. The absence of lowermost Pliocene sediments could suggest that the Betic Strait did not serve as a conduit for the water masses entering the Mediterranean basins during the early Pliocene; and (3) the presence of an early evolutionary stage of Globorotalia margaritae in the Moroccan Bou Regreg section

  2. Evaluation of the Del Mar Avionics automatic ambulatory blood pressure-recording device.

    PubMed

    Sheps, S G; Elveback, L R; Close, E L; Kleven, M K; Bissen, C

    1981-12-01

    We have the opportunity to evaluate a portable ambulatory device for the recording of sequential indirect arterial blood pressure and continuous electrocardiogram (Del Mar Avionics automatic ambulatory blood pressure recording device). With careful attention to technique, only 11% of systolic and 5% of diastolic blood pressure readings differed by more than 10 mm Hg as compared with a trained technician's observations simultaneously in the same arm. The device has been useful in the evaluation of borderline (labile) hypertension, hypertensive drug therapy programs, and various episodic cardiovascular phenomena--for example, vasodepressor syncope and pheochromocytoma crises.

  3. Rotating Kaluza-Klein multi-black holes with Gödel parameter

    NASA Astrophysics Data System (ADS)

    Matsuno, Ken; Ishihara, Hideki; Nakagawa, Toshiharu; Tomizawa, Shinya

    2008-09-01

    We obtain new five-dimensional supersymmetric rotating multi-Kaluza-Klein black hole solutions with the Gödel parameter in the Einstein-Maxwell system with a Chern-Simons term. These solutions have no closed timelike curve outside the black hole horizons. At infinity, the space-time is effectively four-dimensional. Each horizon admits various lens space topologies L(n;1)=S3/Zn in addition to a round S3. The space-time can have outer ergoregions disjointed from the black hole horizons, as well as inner ergoregions attached to each horizon. We discuss the rich structures of ergoregions.

  4. Heavy metal concentrations in litteral sediments from the Beagle Channel, Tierra del Fuego, Argentina.

    PubMed

    Amin, O; Ferrer, L; Marcovecchio, J

    1996-07-01

    For the first time the concentration of trace metals (Fe, Pb, Cu, Zn, Cd and total Hg) of sediments from the coastal zone of the Beagle Channel (Tierra del Fuego, in Southern Argentina) were measured. Atomic absorption spectrophotometry was utilized in order to determine the metal contents. The level of metals as observed in the sediments was recognized as the natural background, even though the use of normalization of lead, copper, and zinc to iron allowed the identification of the main sources of metal pollution for this environment. In order to develop future environmental monitoring programmes for the area of Ushuaia city and the Beagle Channel, the present results need to be considered.

  5. Uranium series dating of human skeletal remains from the Del Mar and Sunnyvale sites, California

    USGS Publications Warehouse

    Bischoff, J.L.; Rosenbauer, R.J.

    1981-01-01

    Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8,300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low. Copyright ?? 1981 AAAS.

  6. 2.3-11.6 Micron Measurements of Nova Del 2013 Consistent with Presence of Dust

    NASA Astrophysics Data System (ADS)

    Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.

    2013-11-01

    Our 2.3-11.6 micron measurements of Nova Del 2013 on 24.04 November 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA) yielded the following magnitudes: K = +5.24 +/- 0.15, L = +3.25 +/- 0.38, M = +2.00 +/- 0.26, [10.3] = -0.17 +/- 0.38, and [11.6] = -0.19 +/- 0.21. An additional measurement on 19.08 November 2013 yielded [10.3] = -0.10 +/- 0.36.

  7. L-Band Measurement of Nova Del 2013 Consistent with Presence of Dust

    NASA Astrophysics Data System (ADS)

    Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.

    2013-09-01

    An L-band measurement of Nova Del 2013 on 29.17 September 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA) yielded a magnitude of L = +2.6 +/- 0.3. Vega (alpha Lyrae) was used as the standard star. This flux level is consistent with a small amount of dust having formed recently as reported in ATEL 5431.

  8. Matuyama-age lithic tools from the Sima del Elefante site, Atapuerca (northern Spain).

    PubMed

    Parés, Josep M; Pérez-González, Alfredo; Rosas, Antonio; Benito, A; Bermúdez de Castro, J M; Carbonell, E; Huguet, R

    2006-02-01

    Paleomagnetic results obtained from the sedimentary fill at the Sima del Elefante site in Atapuerca, Spain, reveal a geomagnetic reversal, interpreted as the Matuyama-Brunhes boundary (0.78 Ma). The uppermost lithostratigraphic units (E17 through E19), which contain Mode II and III archaeological assemblages, display normal polarity magnetization, whereas the six lowermost units (E9 through E16) yield negative latitudinal virtual geomagnetic pole positions. Units E9 through E13, all of which display reverse magnetic polarity, contain Mode I (Oldowan) lithic tools, testifying to the presence of humans in the early Pleistocene (0.78-1.77 Ma). PMID:16249015

  9. Loss of helminth species diversity in the large hairy armadillo Chaetophractus villosus on the Tierra del Fuego Island, Argentina.

    PubMed

    Ezquiaga, M C; Abba, A M; Navone, G T

    2016-03-01

    The aim of this work is to compare the taxonomic diversity of parasite species of the large hairy armadillo Chaetophractus villosus in its native range and in another recently introduced population (Tierra del Fuego island), and to evaluate whether the isolation of the latter determines a decrease in its parasitic diversity. Forty specimens from Buenos Aires and Tierra del Fuego Provinces were collected and examined for helminths. Eleven parasite species were found in the native population, and only one species was present in Tierra del Fuego (Trichohelix tuberculata). This may be explained because isolation and climatic conditions prevent encounters between potential host species and infective forms of parasites. Further sampling will be needed throughout the entire Patagonia steppe to confirm how the characteristic parasitic fauna of C. villosus behaves across the armadillo's southern distribution. PMID:25673233

  10. Basis for a streamflow forecasting system to Rincón del Bonete and Salto Grande (Uruguay)

    NASA Astrophysics Data System (ADS)

    Talento, Stefanie; Terra, Rafael

    2013-10-01

    This paper presents the basis for the design of streamflow prediction systems for the hydroelectric dams of Rincón del Bonete (Uruguay) and Salto Grande (Uruguay-Argentina). The prediction is made, independently, for each reservoir and each month of the year with two methodologies: data-driven statistical models and hybrid downscaling that includes atmospheric predictors. We determine a set of potential predictors and then fit linear models coupled with variable selection techniques, under the hypothesis of perfectly known predictors. The predictive skill of the schemes outperforms the climatological forecast throughout the year in both reservoirs (except August in Rincón del Bonete). This remains the case even when the forecast lead does not allow for the use of preceding flows as predictors. While in Rincón del Bonete it is not possible to distinguish a period of high predictability, in Salto Grande, there is a robust signal in March-May and October-December.

  11. Loss of helminth species diversity in the large hairy armadillo Chaetophractus villosus on the Tierra del Fuego Island, Argentina.

    PubMed

    Ezquiaga, M C; Abba, A M; Navone, G T

    2016-03-01

    The aim of this work is to compare the taxonomic diversity of parasite species of the large hairy armadillo Chaetophractus villosus in its native range and in another recently introduced population (Tierra del Fuego island), and to evaluate whether the isolation of the latter determines a decrease in its parasitic diversity. Forty specimens from Buenos Aires and Tierra del Fuego Provinces were collected and examined for helminths. Eleven parasite species were found in the native population, and only one species was present in Tierra del Fuego (Trichohelix tuberculata). This may be explained because isolation and climatic conditions prevent encounters between potential host species and infective forms of parasites. Further sampling will be needed throughout the entire Patagonia steppe to confirm how the characteristic parasitic fauna of C. villosus behaves across the armadillo's southern distribution.

  12. La meridiana di Egnazio Danti nella Torre dei Venti in Vaticano: un'icona della riforma Gregoriana del calendario

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2014-05-01

    La Torre dei Venti domina l’angolo Sud Ovest del cortile della Pigna (nell'area dei Musei Vaticani), ed è inclusa negli ambienti dell'Archivio Segreto Vaticano. Non è aperta al pubblico, ma è universalmente nota per la fama che da oltre quattrocento anni la circonda, legata alle vicende della riforma Gregoriana del calendario. La meridiana tracciata da padre Egnazio Danti (1536-1586) nella torre dei Venti, fu visitata anche da Gregorio XIII, probabilmente il 21 marzo 1581 come suppone il padre Stein, per convincersi dell'anticipo ormai arrivato a dieci giorni dell'equinozio di primavera sulla data che il concilio di Nicea aveva fissato al 21 marzo per il computo pasquale. La ricognizione astrometrica del febbraio-marzo 2009 fatta dall'autore viene qui presentata.

  13. [Tierra del Fuego: the scientific-political construction of exclusion and counter-image of the ideal city dweller].

    PubMed

    Nacach, Gabriela

    2012-01-01

    Due to its late incorporation into the national State, the social, economic and political setting of the Argentine province Tierra del Fuego differed from that of the rest of the national territory. In the construction of dependent otherness, objectifications and representations were imposed by state-related and non-state-related institutions, among other agencies. In this context, the Salesian mission of La Candelaria and Ushuaia's Jail for recidivists stand out as spaces in which biopolitics was concretised. The native population and criminals in Tierra del Fuego were those to be subjugated. The thesis of the extinction of the Indian and the simultaneous exaltation of the criminal as the subject of progress identified the scientific and political mechanisms by which the exclusion of certain social groups (Tierra del Fuego's indigenous population) and the inclusion of others (criminals) were regulated.

  14. The effect of the common c.2299delG mutation in USH2A on RNA splicing.

    PubMed

    Lenassi, Eva; Saihan, Zubin; Bitner-Glindzicz, Maria; Webster, Andrew R

    2014-05-01

    Recessive variants in the USH2A gene are an important cause of both Usher syndrome and nonsyndromic retinitis pigmentosa. A single base-pair deletion in exon 13 (c.2299delG, p.Glu767Serfs*21) is considered the most frequent mutation of USH2A. It is predicted to generate a premature termination codon and is presumed to lead to nonsense mediated decay. However the effect of this variant on RNA has not been formally investigated. It is not uncommon for exonic sequence alterations to cause aberrant splicing and the aim of the present report is to evaluate the effect of c.2299delG on USH2A transcripts. Nasal cells represent the simplest available tissue to study splicing defects in USH2A. Nasal brushing, RNA extraction from nasal epithelial cells and reverse transcription PCR were performed in five Usher syndrome patients who were homozygous for c.2299delG, two unaffected c.2299delG heterozygotes and seven control individuals. Primers to amplify between exons 12 and 15 and exons 10 and 14 were utilised. Significant variability was observed between different RT-PCR experiments. Importantly, in controls, PCR product of the expected size were amplified on all occasions (13/13 experiments); for patients this was true in only 4/14 experiments (Fisher exact test p = 0.0002). Bioinformatics tools predict the c.2299delG change to disrupt an exonic splicing enhancer and to create an exonic splicing silencer within exon 13. Here, we report an effect of the common c.2299delG mutation on splicing of exons 12 and 13 of USH2A. Future studies are expected to provide important insights into the contribution of this effect on the phenotype.

  15. [I costi farmacologici della terapia di conversione con farmaci biologici nel carcinoma del colon-retto con metastasi epatiche].

    PubMed

    Giuliani, Jacopo; Bonetti, Andrea

    2016-08-01

    Riassunto. Lo scopo di questo studio è quello di valutare i costi dei farmaci (con particolare riferimento alle terapie con farmaci biologici) utilizzati nella terapia di conversione in una popolazione non selezionata di pazienti affetti da carcinoma del colon-retto in stadio avanzato, al fine di ottenere una resezione epatica R0. In questa rassegna sono stati selezionati i report completi e gli aggiornamenti di tutti gli studi clinici randomizzati (di fase II e fase III) che confrontassero almeno 2 regimi di terapia con farmaci biologici in prima linea in pazienti affetti da carcinoma del colon-retto in stadio avanzato di malattia. I costi dei farmaci sono stati ricavati dalla nostra Farmacia Ospedaliera e sono espressi in euro (€). Il nostro studio inizia con la valutazione di 683 abstract. 48 tria sono stati considerati adeguati per una successiva analisi. Una valutazione più approfondita ha portato all'esclusione di 37 trial, lasciando alla valutazione finale 11 studi clinici randomizzati (3 trial di fase II, per un totale di 522 pazienti, e 8 studi di fase III, per un totale di 7191 pazienti). I costi dei farmaci utilizzati nella terapia di conversione aumentano con la sostituzione del 5-fluorouracile con la capecitabina e, in misura maggiore, con l'introduzione degli agenti biologici. In questo lavoro sono presentati due punti chiave. Primo, i costi degli agenti farmacologici utilizzati nei regimi di prima linea a base di agenti biologici più comunemente utilizzati nel trattamento del carcinoma del colon-retto in stadio avanzato sono molto variabili. Secondo, i dati di efficacia dei regimi pubblicati, in termini di tassi di resezione, dipendono dalla selezione dei pazienti, dalle caratteristiche del tumore e dal tipo di schema di terapia.

  16. [I costi farmacologici della terapia di conversione con farmaci biologici nel carcinoma del colon-retto con metastasi epatiche].

    PubMed

    Giuliani, Jacopo; Bonetti, Andrea

    2016-08-01

    Riassunto. Lo scopo di questo studio è quello di valutare i costi dei farmaci (con particolare riferimento alle terapie con farmaci biologici) utilizzati nella terapia di conversione in una popolazione non selezionata di pazienti affetti da carcinoma del colon-retto in stadio avanzato, al fine di ottenere una resezione epatica R0. In questa rassegna sono stati selezionati i report completi e gli aggiornamenti di tutti gli studi clinici randomizzati (di fase II e fase III) che confrontassero almeno 2 regimi di terapia con farmaci biologici in prima linea in pazienti affetti da carcinoma del colon-retto in stadio avanzato di malattia. I costi dei farmaci sono stati ricavati dalla nostra Farmacia Ospedaliera e sono espressi in euro (€). Il nostro studio inizia con la valutazione di 683 abstract. 48 tria sono stati considerati adeguati per una successiva analisi. Una valutazione più approfondita ha portato all'esclusione di 37 trial, lasciando alla valutazione finale 11 studi clinici randomizzati (3 trial di fase II, per un totale di 522 pazienti, e 8 studi di fase III, per un totale di 7191 pazienti). I costi dei farmaci utilizzati nella terapia di conversione aumentano con la sostituzione del 5-fluorouracile con la capecitabina e, in misura maggiore, con l'introduzione degli agenti biologici. In questo lavoro sono presentati due punti chiave. Primo, i costi degli agenti farmacologici utilizzati nei regimi di prima linea a base di agenti biologici più comunemente utilizzati nel trattamento del carcinoma del colon-retto in stadio avanzato sono molto variabili. Secondo, i dati di efficacia dei regimi pubblicati, in termini di tassi di resezione, dipendono dalla selezione dei pazienti, dalle caratteristiche del tumore e dal tipo di schema di terapia. PMID:27571559

  17. K7del is a common TPM2 gene mutation associated with nemaline myopathy and raised myofibre calcium sensitivity.

    PubMed

    Mokbel, Nancy; Ilkovski, Biljana; Kreissl, Michaela; Memo, Massimiliano; Jeffries, Cy M; Marttila, Minttu; Lehtokari, Vilma-Lotta; Lemola, Elina; Grönholm, Mikaela; Yang, Nan; Menard, Dominique; Marcorelles, Pascale; Echaniz-Laguna, Andoni; Reimann, Jens; Vainzof, Mariz; Monnier, Nicole; Ravenscroft, Gianina; McNamara, Elyshia; Nowak, Kristen J; Laing, Nigel G; Wallgren-Pettersson, Carina; Trewhella, Jill; Marston, Steve; Ottenheijm, Coen; North, Kathryn N; Clarke, Nigel F

    2013-02-01

    Mutations in the TPM2 gene, which encodes β-tropomyosin, are an established cause of several congenital skeletal myopathies and distal arthrogryposis. We have identified a TPM2 mutation, p.K7del, in five unrelated families with nemaline myopathy and a consistent distinctive clinical phenotype. Patients develop large joint contractures during childhood, followed by slowly progressive skeletal muscle weakness during adulthood. The TPM2 p.K7del mutation results in the loss of a highly conserved lysine residue near the N-terminus of β-tropomyosin, which is predicted to disrupt head-to-tail polymerization of tropomyosin. Recombinant K7del-β-tropomyosin incorporates poorly into sarcomeres in C2C12 myotubes and has a reduced affinity for actin. Two-dimensional gel electrophoresis of patient muscle and primary patient cultured myotubes showed that mutant protein is expressed but incorporates poorly into sarcomeres and likely accumulates in nemaline rods. In vitro studies using recombinant K7del-β-tropomyosin and force measurements from single dissected patient myofibres showed increased myofilament calcium sensitivity. Together these data indicate that p.K7del is a common recurrent TPM2 mutation associated with mild nemaline myopathy. The p.K7del mutation likely disrupts head-to-tail polymerization of tropomyosin, which impairs incorporation into sarcomeres and also affects the equilibrium of the troponin/tropomyosin-dependent calcium switch of muscle. Joint contractures may stem from chronic muscle hypercontraction due to increased myofibrillar calcium sensitivity while declining strength in adulthood likely arises from other mechanisms, such as myofibre decompensation and fatty infiltration. These results suggest that patients may benefit from therapies that reduce skeletal muscle calcium sensitivity, and we highlight late muscle decompensation as an important cause of morbidity. PMID:23378224

  18. Challenges of modeling current very large lahars at Nevado del Huila Volcano, Colombia

    NASA Astrophysics Data System (ADS)

    Worni, Raphael; Huggel, Christian; Stoffel, M.; Pulgarín, B.

    2012-03-01

    Nevado del Huila, a glacier-covered volcano in the South of Colombia's Cordillera Central, had not experienced any historical eruptions before 2007. In 2007 and 2008, the volcano erupted with phreatic and phreatomagmatic events which produced lahars with flow volumes of up to about 300 million m3 causing severe damage to infrastructure and loss of lives. The magnitude of these lahars and the prevailing potential for similar or even larger events, poses significant hazards to local people and makes appropriate modeling a real challenge. In this study, we analyze the recent lahars to better understand the main processes and then model possible scenarios for future events. We used lahar inundation depths, travel duration, and flow deposits to constrain the dimensions of the 2007 event and applied LAHARZ and FLO-2D for lahar modeling. Measured hydrographs, geophone seismic sensor data and calculated peak discharges served as input data for the reconstruction of flow hydrographs and for calibration of the models. For model validation, results were compared with field data collected along the Páez and Simbola Rivers. Based on the results of the 2007 lahar simulation, we modeled lahar scenarios with volumes between 300 million and 1 billion m3. The approach presented here represents a feasible solution for modeling high-magnitude flows like lahars and allows an assessment of potential future events and related consequences for population centers downstream of Nevado del Huila.

  19. VizieR Online Data Catalog: 1 Del spectroscopy (Kubat+, 2016)

    NASA Astrophysics Data System (ADS)

    Kubat, J.; Kubatova, B.; Dolezalova, B.; Iliev, L.; Slechta, M.

    2016-02-01

    Visual spectra were observed with the Perek 2-m telescope at the Ondrejov Observatory (Czech Republic) with the slit spectrograph in coude focus. We obtained medium-resolution spectra, (R~13000) with the 700-mm spectrograph focus, in which the SITe CCD 2030x800 chip of 15um pixels was used. Our spectra of 1 Del were taken on 16 September 2007. The data were reduced (bias subtracted, flat-fielded, and wavelength calibrated) using the Image Reduction and Analysis Facility (IRAF1). The spectra were normalized to continuum with a straight line to fit the far wings of the Hα line. SINFONI observations were obtained in service mode at the VLT-UT4 (Yepun) telescope at ESO under Programme-ID 093.D-0172(A) during two nights (6 and 10 June 2014). Spectroscopy of 1 Del was carried out with the SINFONI, the AO-assisted integral field spectrograph in all available near-infrared bands (J, H, and K). (2 data files).

  20. Evaporación dinámica del cinturón de asteroides original

    NASA Astrophysics Data System (ADS)

    Brunini, A.

    Hemos integrado numéricamente un enjambre de 3000 partículas en la región del cinturón de asteroides, sujetas a las perturbaciones gravitatorias de Júpiter y Saturno. Al cabo de 107 años, se han formado ya todos los gaps de Kirkwood observados en el cinturón actual. El grupo en la resonancia 3/2 es, aunque en menor grado, también visible. Los tiempos de Lyapunov computados para los asteroides sobrevivientes, nos ha permitido encontrar la fracción de ellos que es capaz de sobrevivir por toda la edad del sistema solar, merced a la aplicacion de la relación empírica que vincula dichos tiempos al tiempo en el cual se manifiestan grandes transiciones orbitales. La fracción de supervivientes es de aproximadamente 1/100. El resto de la masa faltante en el cinturón, es atribuible a colisiones catastróficas con cometas en etapas primordiales.

  1. Estudio del comportamiento tribologico y de las interacciones de superficie de nuevos nanofluidos ionicos

    NASA Astrophysics Data System (ADS)

    Espinosa Rodriguez, Tulia

    tribocorrosion processes. The formation of a coating layer on magnesium alloys from phosphonate imidazolium ionic liquids by immersion and by chronoamperometry has been described. The new coatings reduce the abrasive wear in the magnesium-aluminium alloy but they are not effective in the magnesium-zinc alloy, which prevent the formation of continuous coatings. Los liquidos ionicos son sales liquidas a temperatura ambiente o bajas temperaturas que presentan excelentes propiedades fisico-quimicas. En el presente trabajo se estudian como lubricantes en problemas tribologicos complejos como la lubricacion de metales contra si mismos, el desarrollo de lubricantes base agua y de nuevas superficies autolubricadas. Cuando no es posible reducir la friccion y desgaste mediante lubricacion, como en las aleaciones de magnesio, los liquidos ionicos se han estudiado como precursores de recubrimientos protectores. Se han determinado las interacciones superficiales y los procesos de corrosion sobre cobre y sobre acero con diferentes liquidos ionicos proticos y aproticos para desarrollar nuevos lubricantes y aditivos. En el contacto cobre/cobre, excepto el liquido ionico protico derivado del oleato, todos los liquidos ionicos estudiados presentan mejor comportamiento tribologico que el lubricante comercial Polialfaolefina 6. En el contacto acero/zafiro, los nuevos liquidos ionicos proticos son buenos lubricantes cuando se utilizan en estado puro, y, como aditivos en agua, generan peliculas adsorbidas sobre la superficie del metal reduciendo la friccion y el desgaste tras la evaporacion del agua. Para evitar el periodo de alta friccion inicial en presencia de agua, se han generado peliculas superficiales de liquido ionico sobre el acero en condiciones estaticas. El mejor comportamiento lubricante tanto en el contacto cobre/cobre como en el contacto acero/zafiro se obtiene para el liquido ionico protico derivado del anion adipato, con dos grupos carboxilicos. Las interacciones de los grupos

  2. Implementation of tsunami disaster prevention measures in the municipality of San Rafael del Sur, Nicaragua

    NASA Astrophysics Data System (ADS)

    Strauch, W.; Talavera, E.; Acosta, N.; Sanchez, M.; Mejia, E.

    2007-05-01

    The Nicaraguan Pacific coast presents considerable tsunami risk. On September 1, 1992, a tsunami caused enormous damage in the infrastructure and killed more than 170 people. A pilot project was conducted between 2006 and 2007 in the municipality of San Rafel del Sur, area of Masachapa, The project included multiple topics of tsunami prevention measures and considering the direct participation of the local population, as: -General education on disaster prevention, participative events; -Investigation of awareness level and information needs for different population groups; -Specific educational measures in the schools; -Publication of brochures, calendars, news paper articles, radio programs, TV spots -Development of local tsunami hazard maps, 1:5,000 scale; (based on previous regional tsunami hazard mapping projects and local participation) -Development of a tsunami warning plan; -Improvements of the national tsunami warning system. -Installation of sirens for tsunami warning -Installation of tsunami signs, indicating hazardous areas, evacuation routes, safe places; -Realization of evacuation drills in schools. Based on the experiences gained in Masachapa it is planned to run similar projects in other areas along the Nicaraguan Pacific coast. In the project participated the local municipality and local stakeholders of San Rafael del Sur, Ministry of Education, National Police, Nicaraguan Red Cross, Ministry of Health, Ministry of Tourism, Nicaraguan Geosciences Institute (INETER), National System for Disaster Prevention (SINAPRED), Swiss Agency for Development and Cooperation (SDC). It was financed by SDC and INETER.

  3. Features of Lactobacillus Sakei Isolated from Italian Sausages: Focus on Strains from Ventricina del Vastese

    PubMed Central

    Amadoro, Carmela; Piccirilli, Michele; Colavita, Giampaolo

    2015-01-01

    In this study bacterial isolates from Ventricina del Vastese sausage, previously identified as Lactobacillus (L.) sakei, were characterised genotypically, physiologically and on the basis of some technologically relevant traits. A total of 70 L. sakei isolates from sausages manufactured with spontaneous fermentation in the same producing plant were taken into account. Six genotypic groups were distinguished on the basis of Rep-polymerase chain reaction with the GTG5 primer, some of which were found only in the sausages ripened at temperatures lower than 10°C for the first two months and lower than 16°C for the remaining three months, according to the traditional ripening process. Six strains were selected as representative of the genotypic profiles and further characterised. A high diversity in their fermentation profiles was observed, and different groups were separated on the basis of growth and acidifying capacity in meat extract. None of the strains produced histamine or tyramine in vitro. One strain was able to slightly inhibit Listeria (L.) monocytogenes and L. innocua and all six strains were able to slightly inhibit Enterobacteriaceae isolated from Ventricina del Vastese sausages in vitro. Results showed that most L. sakei strains can have a role in improving the safety of low acidity fermented sausages, even though a limited acidifying capacity was observed in a meat-like substrate, and that L. sakei strains able to produce biogenic amines are unlikely to occur in spontaneously fermented meat products. PMID:27802352

  4. EU Del: exploring the onset of pulsation-driven winds in giant stars

    NASA Astrophysics Data System (ADS)

    McDonald, I.; Zijlstra, A. A.; Sloan, G. C.; Lagadec, E.; Johnson, C. I.; Uttenthaler, S.; Jones, O. C.; Smith, C. L.

    2016-03-01

    We explore the wind-driving mechanism of giant stars through the nearby (117 pc), intermediate-luminosity (L ≈ 1600 L⊙) star EU Del (HIP 101810, HD 196610). Atacama Pathfinder Experiment observations of the CO (3-2) and (2-1) transitions are used to derive a wind velocity of 9.51 ± 0.02 km s-1, a 12C/13C ratio of 14^{+9}_{-4} and a mass-loss rate of a few × 10-8 M⊙ yr-1. Analysis of published spectra show the star has a metallicity of [Fe/H] = -0.27 ± ˜0.30 dex. The star's dusty envelope lacks a clear 10-μm silicate feature, despite the star's oxygen-rich nature. Radiative transfer modelling cannot fit a wind acceleration model which relies solely on radiation pressure on condensing dust. We compare our results to VY Leo (HIP 53449), a star with similar temperature and luminosity, but different pulsation properties. We suggest the much stronger mass-loss from EU Del may be driven by long-period stellar pulsations, due to its potentially lower mass. We explore the implications for the mass-loss rate and wind velocities of other stars.

  5. Isolation of Sphaerotilus-Leptothrix strains from iron bacteria communities in Tierra del Fuego wetlands.

    PubMed

    Schmidt, Bertram; Sánchez, Leandro A; Fretschner, Till; Kreps, Gastón; Ferrero, Marcela A; Siñeriz, Faustino; Szewzyk, Ulrich

    2014-11-01

    Sheath-forming iron- and manganese-depositing bacteria belonging to the Sphaerotilus-Leptothrix group (SLG) are widespread in natural and artificial water systems. Known requirements for their growth include the presence of organic substrates and molecular oxygen. High concentrations of reduced iron or manganese, although not necessary for most species, make their growth a noticeable phenomenon. Such microbial communities have been studied mostly in the Northern Hemisphere. Here, we present descriptions of diverse ochre-depositing microbial communities in Tierra del Fuego, Argentina, using a combined approach of microscopical examination, clone library construction and cultivation focused on SLG bacteria. To date, only few SLG type strains are available. The present work increases the number and diversity of cultivated SLG bacteria by obtaining isolates from biofilms and sediment samples of wetlands in Tierra del Fuego. Thirty isolates were selected based on morphological features such as sheath formation and iron/manganese deposition. Five operational taxonomic units (OTUs) were deduced. Sequencing of 16S rRNA genes showed that one OTU is identical to the Leptothrix mobilis Feox-1(T) -sequence while the four remaining OTUs show similarity values related to previously described type strains. Similarity values ranged from 96.5% to 98.8%, indicating possible new species and subspecies. PMID:25098830

  6. AdS-like spectrum of the asymptotically Gödel space-times

    NASA Astrophysics Data System (ADS)

    Konoplya, R. A.; Zhidenko, A.

    2011-09-01

    A black hole immersed in a rotating universe, described by the Gimon-Hashimoto solution, is tested on stability against scalar field perturbations. Unlike the previous studies on perturbations of this solution, which dealt only with the limit of slow universe rotation j, we managed to separate variables in the perturbation equation for the general case of arbitrary rotation. This leads to qualitatively different dynamics of perturbations, because the exact effective potential does not allow for Schwarzschild-like asymptotic of the wave function in the form of purely outgoing waves. The Dirichlet boundary conditions are allowed instead, which result in a totally different spectrum of asymptotically Gödel black holes: the spectrum of quasinormal frequencies is similar to the one of asymptotically anti-de Sitter black holes. At large and intermediate overtones N, the spectrum is equidistant in N. In the limit of small black holes, quasinormal modes (QNMs) approach the normal modes of the empty Gödel space-time. There is no evidence of instability in the found frequencies, which supports the idea that the existence of closed timelike curves (CTCs) and the onset of instability correlate (if at all) not in a straightforward way.

  7. Epidemiological surveillance of cystic echinococcosis in rural population of Tierra del Fuego, Argentina, 1997-2006.

    PubMed

    Zanini, Fabián; Suárez, Carlos; Pérez, Héctor; Elissondo, María C

    2009-03-01

    Cystic echinococcosis (CE) is the most prevalent zoonosis in Tierra del Fuego. In 1997, ulrasonography (US) was selected as the method of choice for the development of population surveys for epidemiological surveillance and early diagnosis in rural population. The aim of this work was to present the results of the epidemiological surveillance of CE by means of US in rural population of Tierra del Fuego, Argentina between 1997 and 2006. The ultrasonographic diagnostic was realized once a year. The population was stratified in children (4 to 17 years) and adults. From each individual, name, age, sex, actual residence and origin were registered. The images compatible with cysts were graded according to location, number and characteristics. A total of 1400 rural inhabitants were examined for CE. From the total of studied individuals, 27 (1.9%) exhibited images compatible with cysts on the abdominal ultrasound scan. Thirteen of these persons were finally diagnosed as having CE. The overall prevalence of CE was 0.9%. This value is in accordance with the decrease in the prevalence observed in the definitive host and the intermediate hosts (sheep and cattle). The absence of cases in children during the studied period, evidence no transmission of the disease to humans in the recent past.

  8. Large residuals on geoidal heights determined on the Fagnano Lake, Tierra del Fuego-Argentina

    NASA Astrophysics Data System (ADS)

    Gomez, M. E.; Del Cogliano, D.; Perdomo, R.

    2013-05-01

    A new geoid model was developed in Tierra del Fuego and it was evaluated in the area of Fagnano Lake. The model was developed by means of the Equivalent Source Technique combining gravity data, levelling information measured on the province and observations of a GPS buoy on the Fagnano Lake. Those GPS buoy measurements provide information of the mean lake level surface (Del Cogliano et al., 2007). A cross validation process was realized in order to evaluate the model on the lake. What allowed determining a 6 cm geoid in the area of Fagnano Lake. Also, an evaluation of the EGM2008 (Pavlis et al., 2008) was made on the lake. Its behaviour was compared to that observed on the levelling lines. Differences of several decimetres were found when EGM2008 undulations were compared to observed geoid undulations in the lake area. In the regions where EGM2008 has included real gravimetric observations, differences between model and observations were only of a few centimetres. Such model has the particularity that includes fill-in gravity in that region. The above mentioned evaluation derived in an analysis of the effect that not representative gravity information could have on the estimation of geoid undulations in high mountainous regions. We found that this effect could be significant if there is no real information in the computing area (Gomez et al, 2012).

  9. Isolation of Sphaerotilus-Leptothrix strains from iron bacteria communities in Tierra del Fuego wetlands.

    PubMed

    Schmidt, Bertram; Sánchez, Leandro A; Fretschner, Till; Kreps, Gastón; Ferrero, Marcela A; Siñeriz, Faustino; Szewzyk, Ulrich

    2014-11-01

    Sheath-forming iron- and manganese-depositing bacteria belonging to the Sphaerotilus-Leptothrix group (SLG) are widespread in natural and artificial water systems. Known requirements for their growth include the presence of organic substrates and molecular oxygen. High concentrations of reduced iron or manganese, although not necessary for most species, make their growth a noticeable phenomenon. Such microbial communities have been studied mostly in the Northern Hemisphere. Here, we present descriptions of diverse ochre-depositing microbial communities in Tierra del Fuego, Argentina, using a combined approach of microscopical examination, clone library construction and cultivation focused on SLG bacteria. To date, only few SLG type strains are available. The present work increases the number and diversity of cultivated SLG bacteria by obtaining isolates from biofilms and sediment samples of wetlands in Tierra del Fuego. Thirty isolates were selected based on morphological features such as sheath formation and iron/manganese deposition. Five operational taxonomic units (OTUs) were deduced. Sequencing of 16S rRNA genes showed that one OTU is identical to the Leptothrix mobilis Feox-1(T) -sequence while the four remaining OTUs show similarity values related to previously described type strains. Similarity values ranged from 96.5% to 98.8%, indicating possible new species and subspecies.

  10. Aplicación del Teorema de Nekhorochev para tiempos de estabilidad en Mecánica Celeste

    NASA Astrophysics Data System (ADS)

    Miloni, O.; Núñez, J.; Brunini, A.

    En Mecánica Celeste, uno de los problemas centrales consiste en la determinación de los tiempos de estabilidad. El teorema de Nekhorochev proporciona un método para dicho estudio, para un sistema determinado por un hamiltoniano descripto en las variables acción-ángulo. El trabajo consiste en la acotación tanto del potencial perturbador y de la matriz hessiana del hamiltoniano integrable para determinar luego el tiempo de estabilidad de dicho sistema, donde por estabilidad se entiende la separación en norma infinito en el espacio de las acciones.

  11. Massless Spin-Zero Particle and the Classical Action via Hamilton-Jacobi Equation in Gödel Universe

    NASA Astrophysics Data System (ADS)

    Bahrehbakhsh, A. F.; Momeni, D.; Myrzakulov, R.

    2012-08-01

    In this letter we investigate the separability of the Klein-Gordon and Hamilton-Jacobi equation in Gödel universe. We show that the Klein-Gordon eigen modes are quantized and the complete spectrum of the particle's energy is a mixture of an azimuthal quantum number, m and a principal quantum number, n and a continuous wave number k. We also show that the Hamilton-Jacobi equation gives a closed function for classical action. These results may be used to calculate the Casimir vacuum energy in Gödel universe.

  12. Aspectos generales de los exámenes de detección del cáncer (PDQ®)—Versión para profesionales de salud

    Cancer.gov

    Información sobre la medición de la eficacia de las pruebas de detección del cáncer y la evaluación de la solidez de las pruebas obtenidas en estudios de investigación de detección del cáncer.

  13. Newly emerged isolated Del(7q) in patients with prior cytotoxic therapies may not always be associated with therapy-related myeloid neoplasms.

    PubMed

    Goswami, Rashmi S; Wang, Sa A; DiNardo, Courtney; Tang, Zhenya; Li, Yan; Zuo, Wenli; Hu, Shimin; Li, Shaoying; Medeiros, L Jeffrey; Tang, Guilin

    2016-07-01

    Deletion 7q is a common chromosomal abnormality in myeloid neoplasms. Detection of del(7q) in patients following cytotoxic therapies is highly suggestive of an emerging therapy-related myeloid neoplasm. In this study, we describe 39 patients who acquired del(7q) as a sole abnormality in their bone marrow following cytotoxic therapies for malignant neoplasms. The median interval from cytotoxic therapies to detection of del(7q) was 40 months (range, 4-190 months). Twenty-eight patients showed an interstitial and 11 showed a terminal 7q deletion. Fifteen patients (38%) had del(7q) as a large clone and 24 (62%) as a small clone. With a median follow-up of 21 months (range, 1-135 months), 18 (46%) patients developed therapy-related myeloid neoplasms, including all 15 patients with a large del(7q) clone and 3/24 (12.5%) with a small clone. Of the remaining 21 patients with a small del(7q) clone, 16 showed no evidence of therapy-related myeloid neoplasms and 5 had an inconclusive pathological diagnosis. We conclude that isolated del(7q) emerging in patients after cytotoxic therapy may not always be associated with therapy-related myeloid neoplasms in about half of patients. The clone size of del(7q) is critical; a large clone is almost always associated with therapy-related myeloid neoplasms, whereas a small clone can be a clinically indolent or transient finding.

  14. Aspectos generales de los exámenes de detección del cáncer (PDQ®)—Versión para pacientes

    Cancer.gov

    Información sobre la medición de la eficacia de los exámenes de detección del cáncer y la evaluación de la solidez de las pruebas obtenidas en estudios de investigación de detección del cáncer.

  15. 77 FR 4897 - Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James River, Isle of Wight, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James... live-fire gun exercises on the M/V Del Monte. This action is intended to restrict vessel traffic movement to protect mariners from the hazards associated with the live-fire gun exercise. DATES: This...

  16. 76 FR 31848 - Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James River, Isle of Wight, Virginia

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James... the live-fire gun exercises on the M/V Del Monte. This action is intended to restrict vessel traffic movement to protect mariners from the hazards associated with the live-fire gun exercise. DATES: This...

  17. Centro para la Salud Mundial del NCI anuncia becas de investigación para tecnologías portátiles

    Cancer.gov

    El Centro para la Salud Mundial del NCI (CGH) anunció el otorgamiento de subvenciones que apoyarán el desarrollo y la validación de tecnologías portátiles y de bajo costo para mejorar la detección temprana, el diagnóstico y el tratamiento del cáncer.

  18. The December 2002 Sciara del Fuoco (Stromboli Island) submarine landslide: a first characterization

    NASA Astrophysics Data System (ADS)

    Chiocci, F. L.; Bosman, A.; Romagnoli, C.; Tommasi, P.; de Alteris, G.

    2003-04-01

    On December 2002 a major instability event occurred on Sciara del Fuoco, on the western flank of Stromboli Island. Sciara del Fuoco is the most striking feature of Stromboli and represents the subaerial part of a partially filled sector-collapse scar that formed in the last of a series of major collapses affecting the island in the last 13 ka. This sector of the volcanic cone has been the site of persistent volcanism during the last thousand years and acts as a channelway to the sea for most of the eruptive products. The instability event was preceeded by a lava flow emission along the northern side of the Sciara scar, which started on December 28. On December 30, a tsunami wave starting from Sciara del Fuoco propagated around the whole island and in the surrounding sectors of the Aeolian archipelago and it was felt as far as the Sicily coast. At Stromboli the wave caused heavy damage to houses and infrastructures, mostly along the northeastern coast of the island. No casualties occurred, mainly due to the paucity of inhabitants during the winter season. Just before the tsunami wave propagation, two landslides occurred on the Sciara slope; nevertheless, the total volume of rocks involved in the subaerial phenomena (about 8 million of cubic meters) appeared not enough to explain such an energy radiation. In the first few days after the event, a multibeam survey was carried out, aboard a vessel of the local Coast Guard, in front of Sciara del Fuoco, down to 2000m of depth. The availability of a multibeam bathymetry collected ten months before, in the framework of the Italian National Group for Volcanology research activities, gave us a unique opportunity to compare the pre- and post-event settings in a very short span of time. A detailed definition of volumes involved and morphology generated by the event was then realized. The first results are the following: an impressive scar was produced down to the depth of 800 m; in the coastal area the scar is over 40 m deep

  19. Genetic polymorphism in HLA-G 3'UTR 14-bp ins/del and risk of cancer: a meta-analysis of case-control study.

    PubMed

    Li, Tao; Huang, Haohai; Liao, Dan; Ling, Huahuang; Su, Bingguang; Cai, Maode

    2015-08-01

    Accumulating evidence has suggested that the human leucocyte antigen-G (HLA-G) 14 bp ins/del polymorphism might be related to cancer susceptibility. However, epidemiologic findings have been inconsistent. Therefore, we performed a meta-analysis of case-control study to derive a more precise estimation of this association. Electronic databases were searched to identify all eligible studies of HLA-G 14 bp ins/del polymorphism and cancer risk. Odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated to evaluate the strength of the association in fixed-effects model or random-effects model according to heterogeneity. Publication bias, sensitivity analysis and subgroup analyses based on cancer type, ethnicity, source of controls and sample size were also performed. A total of 14 case-control studies, involving 2,757 cases and 3,972 controls, were included in the present meta-analysis. The pooled analysis showed that there is no significant relationship between the HLA-G 14 bp ins/del polymorphism and cancer susceptibility under the genetic models (for the allele model del vs. ins: OR 1.13, 95 % CI 1.00-1.27; for the homozygote comparison model del/del vs. ins/ins: OR 1.22, 95 % CI 0.95-1.56; for the dominant model del/del + ins/del vs. ins/ins: OR 1.15, 95 % CI 0.94-1.42; for recessive model del/del vs. ins/del + ins/ins: OR 1.13, 95 % CI 0.96-1.34; respectively). Subgroup analyses indicated significant association among breast cancer, population based control and the large sample size group in some genetic models. Our investigations demonstrate that genotypes for the HLA-G 14 bp ins/del polymorphism may be not associated with overall cancer risk. In a subgroup meta-analysis, however, HLA-G 14-bp ins/del polymorphism might contribute to breast cancer susceptibility.

  20. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.

    PubMed

    Chandran, Divya; Rickert, Joshua; Huang, Yingxiang; Steinwand, Michael A; Marr, Sharon K; Wildermuth, Mary C

    2014-04-01

    In plants, the activation of immunity is often inversely correlated with growth. Mechanisms that control plant growth in the context of pathogen challenge and immunity are unclear. Investigating Arabidopsis infection with the powdery mildew fungus, we find that the Arabidopsis atypical E2F DEL1, a transcriptional repressor known to promote cell proliferation, represses accumulation of the hormone salicylic acid (SA), an established regulator of plant immunity. DEL1-deficient plants are more resistant to pathogens and slightly smaller than wild-type. The resistance and size phenotypes of DEL1-deficient plants are due to the induction of SA and activation of immunity in the absence of pathogen challenge. Moreover, Enhanced Disease Susceptibility 5 (EDS5), a SA transporter required for elevated SA and immunity, is a direct repressed target of DEL1. Together, these findings indicate that DEL1 control of SA levels contributes to regulating the balance between growth and immunity in developing leaves.