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Sample records for del hospital dr

  1. Dr. William Briggs: ophthalmic physician at St. Thomas' Hospital, London.

    PubMed

    Winstanley, J

    2001-01-01

    William Briggs, MD, established himself as one of the first ophthalmic physicians, whom today we would call a neuro-ophthalmologist, to practice in the United Kingdom. After graduating with an MD from Cambridge in 1677, and while a Fellow of Corpus Christi College, he carried out original studies in visual anatomy and physiology. He described and named the optic papilla and the retinal nerve fibers in his book Ophthalmographia, published in 1676. He published his New Theory of Vision in 1682. While at Cambridge, he was a contemporary and a friend of Isaac Newton, with whom Briggs worked but who, in matters of visual anatomy and physiology, came to reach different conclusions from Briggs. In 1683, Briggs came to London to practice as a physician at St. Thomas' Hospital, where he established a considerable reputation as an ophthalmologist. For political reasons he was forced to resign from the Hospital prematurely.

  2. Revoking hospital privileges: new directions in Ontario. Dr. N. v. Brantford General Hospital.

    PubMed

    Liswood, J; McClure, A E

    1993-01-01

    Recent decisions by the Ontario Hospital Appeal Board have helped hospital boards understand the importance of due process when revoking a physician's hospital privileges. The authors illustrate the need to have a mechanism to suspend privileges immediately but which also provides physicians with the opportunity to respond to allegations. The article outlines 11 clauses that serve as a practical guide to due process and can be added to hospital by-laws.

  3. [DR ALEKSANDAR DORŠNER THE FIRST HOSPITAL OTORHINOLARYNGOLOGIST IN SPLIT AND DALMATIA].

    PubMed

    Ivanišević, Petar; Poljak, Nikola Kolja; Cikojević, Draško; Doršner, Katarina; Ivanišević, Milan

    2015-01-01

    Dr Aleksandar Doršner (Trebinje, 1892 - Lima, 1967) was the first hospital otorhinolaryngologist in Split and Dalmatia. He graduated from the Faculty of Medicine in Prague in 1919, and specialized otorhinolaryngology in Graz and Vienna. He led and organized otorhinolaryngological service in Split Hospital from 1923 to 1934, and he also had a private practice. Temporarily he also worked outside Split in Dalmatian hinterland and in Šibenik, Zadar and Dubrovnik. Most frequently he performed the following otorhinolaryngological operations: tonsillectomies and adenoidectomies and operations of purulent middle ear inflammations with mastoiditis, nasal polyps, deviated nasal septum, maxillary sinus empyema and otorhinolaryngological trauma. In 1928 he became a member of Otorhinolaryngological section of Croatian Medical Chamber. He participated in the work of the first otorhinolaryngological congress of the former Yugoslavia in 1931, taken place in Zagreb. From 1928 he was a member of Oto-Neuro-Ophthalmological Society. From 1933 to 1937 he was a vice-president of the main board of Free Organization of Dalmatian Physicians in Split. In 1938 he left Split permanently and continued living with his family in Lima (Peru) where he died in 1967. He was an erudite. He lived for his profession which he liked very much and dedicated his life to. He is one of the most meritorious doctors in Split medical history, whom otorhinolaryngology service in Split Hospital started with.

  4. Revolutionary changes in medicine and ophthalmology--the St. Louis, MO, effect: Homer G. Phillips Hospital and Dr. Howard Phillip venable.

    PubMed Central

    Johnson, Andrew S.

    2003-01-01

    PURPOSE: To provide information on the revolutionary changes in medicine, particularly on the development of African-Americans in ophthalmology, created by Homer G. Phillips Hospital in St. Louis and the late Dr. Howard Phillip Venable. METHODS: Very little has been written about Homer G. Phillips Hospital and Dr. H. Phillip Venable. Through personal interviews with physicians trained by Dr. Venable and literature review, I was able to obtain information on Homer G. Phillips Hospital and Dr. Venable's influence in breaking the color line in medicine and ophthalmology. RESULTS: Homer G. Phillips Hospital in St. Louis was a major teaching hospital for African-American doctors. Dr. Venable was one of a few African-American ophthalmologists in the 1940s. Dr. Venable then trained approximately 40 African-American ophthalmologists at Homer G. Phillips Hospital between 1943 to 1979, when the hospital closed. CONCLUSION: The ophthalmologists trained by Dr. Venable have gone forward to treat thousands of patients with blinding eye diseases such as glaucoma and diabetes, and to influence others to become ophthalmologists. Although the hospital has closed and Dr. Venable has passed away, their existence has reformed the medical treatment received by African-Americans and other people. Images p484-a PMID:12856914

  5. Dr Walter Henry Anderson (1870-1937) and the mission hospital at Safed, Palestine.

    PubMed

    Stokes, Gordon S

    2013-02-01

    Walter Henry Anderson, a brewer's clerk in Burton-upon-Trent, became a missionary doctor, supported by a society promoting welfare and evangelism in Jewish communities abroad. His family background was rich in pastoral ministry at home and adventure abroad. Arguably, this background played a part in his decision to serve the Jews of Safed. His life in Palestine entailed much enterprise and hardship as he raised a family, fought disease and set up a mission hospital serving not only the Jewish community but persons of all faiths. His years in Palestine, from 1894 to 1915, were times of peace in the Middle East before the turmoil unleashed by the Great War. Jews from the Diaspora were gaining an increasing foothold in Palestine, their 'Promised Land'. Themes of that era - the rise of Zionism, confrontation between Judaism and evangelical Christianity, conflict between immigrant Jew and Palestinian Arab and the remarkable travels of Lawrence of Arabia were interwoven with the lives of Dr Anderson and his family.

  6. Evaluation of Nosocomial Infection in Patients at hematology-oncology ward of Dr. Sheikh children’s hospital

    PubMed Central

    Ghassemi, A; Farhangi, H; Badiee, Z; Banihashem, A; Mosaddegh, MR

    2015-01-01

    Background Infections in critical care unit are high, and they are serious hospital problems. Infections acquired during the hospital stay are generally called nosocomial infections, initially known as infections arising after 48 h of hospital admission. The mostfrequent nosocomial infections (urinary, respiratory, gastroenteritis and blood stream infection) were common in patients at hospital.The aim was to study, the current status of nosocomial infection, rate of infection among hospitalized children at hematology-oncology ward of Dr. Sheikh children’s hospital, Mashhad, Iran. Materials and Methods Data were collected from 200 patient's records presented with symptoms of nosocomial infection at hematology-oncology ward of Dr. Sheikh children’s hospital from March 2014 to September 2014. Descriptive statistics using percentage was calculated. Results Incidence of nosocomial infections inpatients athematology-oncology ward was 31% (62/200). Of which 69.35% (43/62) blood stream infection being the most frequent; followed by 30.64% (19/62) was urinary tract infection (UTI), and the most common blood culture isolate was been Staphylococcus epidermidis 18 (41.86%), andour study showed that large numbers ofnosocomial UTIs causing by Gram‑negative bacteria. Conclusion This study showed blood stream infection and UTI are the common nosocomial infections among patients athematology-oncology ward. Early recognition of infections and short term use of invasive devices along with proper infection control procedures can significantly decrease the incidence of nosocomial infections in patients. PMID:26985350

  7. [Prevalence of gastrointestinal disorders in adults with common variable immunodeficiency at Specialty Hospital Dr. Bernardo Sepulveda].

    PubMed

    Rodríguez-Negrete, Elda Victoria; Mayoral-Zavala, Arturo; Rodríguez-Mireles, Karen Alicia; Díaz de León-Salazar, Oscar Edmundo; Hernández-Mondragón, Oscar; Gómez-Jiménez, Luz María; Moreno-Alcántar, R; González-Virla, Baldomero

    2015-01-01

    Antecedentes: la incidencia de la inmunodeficiencia común variable (IDCV) es de 1 por cada 15,000 a 117,000 casos, sin predominio de género. La incidencia de manifestaciones gastrointestinales en estos pacientes es de 20 a 60% y pueden ser la primera y única manifestación clínica de IDCV. En México existe escasa información en relación con el tipo y frecuencia de alteraciones gastrointestinales que padecen los pacientes adultos con IDCV. Objetivo: determinar la prevalencia de alteraciones gastrointestinales en pacientes adultos con inmunodeficiencia común variable. Material y método: estudio descriptivo, observacional y transversal en el que participaron pacientes con inmunodeficiencia común variable de la Clínica de Inmunodeficiencias del Servicio de Alergia e Inmunología Clínica del Hospital de Especialidades, Centro Médico Nacional Siglo XXI. A todos los pacientes se les aplicó un cuestionario de síntomas gastrointestinales y se les realizaron estudios de laboratorio, gabinete, endoscopia y prueba de aliento para determinar sobrepoblación bacteriana. Resultados: evaluamos 17 pacientes, 8 hombres y 9 mujeres, con edad promedio de 36 años y diagnóstico definitivo de inmunodeficiencia común variable de acuerdo con criterios internacionales. El 59% refirió dolor abdominal, 53% distensión abdominal y 17.6% estreñimiento. El 47% tenía diarrea crónica, en dos de ellos (11.8%) acompañada de pujo rectal. Las enfermedades gastrointestinales de esta población fueron: 18% diarrea crónica, enfermedad celiaca y sobrepoblación bacteriana, 24% trastorno funcional digestivo, 12% estreñimiento, 6% dispepsia. Sólo un paciente (6%) no tenía síntomas gastrointestinales. Conclusión: la prevalencia de las enfermedades gastrointestinales en pacientes adultos con inmunodeficiencia común variable fue de 94%, sin predominio de género. Debido a la frecuencia de manifestaciones gastrointestinales, es importante realizar protocolos de estudio al respecto

  8. [Tuberculous meningitis: a 10-year analysis at the "Dr. Federico Gómez" Children's Hospital of Mexico].

    PubMed

    Karam Bechara, J; Sosa, R; Naime Libien, J E; Posada Maldonado, E E

    1991-01-01

    Of all the forms of tuberculous infection in children, the most frequent is the pulmonary, but the tuberculous meningitis is the most severe and mortal, it occurs mainly in children under five years old, and the highest mortality is in children under two. The results of a retrospective study carried out at the Children Hospital of Mexico "Dr. Federico Gómez" about all the patients hospitalized with tuberculous meningitis diagnose during the January 1975 to December 1985 period were presented. One hundred and eighteen cases were studied: the majority (80%) corresponded to children under four years old, a percentage of 79 presented some degree of malnutrition, and 86 per cent showed clinical data of neurological affection. The confirmation of the diagnose was made in the majority of cases through laboratory and cabinet studies. Forty per cent showed no alteration in the chest X-rays, and the isolation of the bacillus was in a very low percentage (15%). All the patients were treated with the antituberculous drugs mentioned, with a better development in the ones associated with steroids. The hospital stay was over 30 days in 15 per cent of the cases. The mortality of the series reviewed was 44.5 per cent.

  9. [Genotyping of Cryptococcus neoformans/Cryptococcus gattii complex clinical isolates from Hospital "Dr. Julio C. Perrando", Resistencia city (Chaco, Argentina)].

    PubMed

    Cattana, Maria E; Tracogna, Maria F; Fernández, Mariana S; Carol Rey, Mariana C; Sosa, Maria A; Giusiano, Gustavo E

    2013-01-01

    Cryptococcosis is a fungal infection caused by yeast species of Cryptococcus genus, particularly Cryptococcus neoformans/Cryptococcus gattii species complex. The knowledge of the cryptococcosis casuistic in northeastern Argentina is scarce and there is no information about the molecular types circulating in this area. The aim of this study was to genotyping C. neoformans/C. gattii complex clinical isolates obtained at Hospital "Dr. Julio C. Perrando", Resistencia city (Chaco, Argentina), in order to determine species, variety and molecular type. During two years and one month 26 clinical isolates were studied. Using conventional and molecular methods one isolate was identified as C. gattii VGI type, and 25 isolates as C. neoformans var. grubii; 23 of these belonged to VNI type and two belonged to VNII type. This data is a contribution to the knowledge of cryptococcosis epidemiology in Argentina and the first report about C. neoformans/ C. gattii complex molecular types from clinical isolates in northeastern Argentina.

  10. The development of pediatric critical care medicine at The Children's Hospital of Philadelphia: an interview with Dr. John J. 'Jack' Downes.

    PubMed

    Mai, Christine L; Schreiner, Mark S; Firth, Paul G; Yaster, Myron

    2013-07-01

    Dr. John J. 'Jack' Downes (1930-), the anesthesiologist-in-chief at The Children's Hospital of Philadelphia (1972-1996), has made numerous contributions to pediatric anesthesia and critical care medicine through a broad spectrum of research on chronic respiratory failure, status asthmaticus, postoperative risks of apnea in premature infants, and home-assisted mechanical ventilation. However, his defining moment was in January 1967, when The Children's Hospital of Philadelphia inaugurated its pediatric intensive care unit--the first of its kind in North America. During his tenure, he and his colleagues trained an entire generation of pediatric anesthesiologists and intensivists and set a standard of care and professionalism that continues to the present day. Based on an interview with Dr. Downes, this article reviews a career that advanced pediatric anesthesia and critical care medicine and describes the development of that first pediatric intensive care unit at The Children's Hospital of Philadelphia.

  11. The contribution of Dr. Mary Walker towards myasthenia gravis and periodic paralysis whilst working in poor law hospitals in London.

    PubMed

    Johnston, J D

    2005-06-01

    Dr. Mary Walker discovered in 1934 that physostigmine and Prostigmin temporarily restored muscle function in patients with myasthenia gravis. In the next five years, Dr. Walker and colleagues provided clinical evidence for the weakness of myasthenia gravis being caused by a "disturbance of transmission of excitation from motor nerve to voluntary muscle presumably caused by a deficiency of acetylcholine. Physostigmine (or Prostigmin) compensated for the lack of acetylcholine by delaying its destruction." Dr. Walker and colleagues also described the association between familial periodic paralysis and hypokalaemia.

  12. PREVALENCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS FROM NOSE AND THROAT OF PATIENTS ON ADMISSION TO MEDICAL WARDS OF DR SOETOMO HOSPITAL, SURABAYA, INDONESIA.

    PubMed

    Kuntaman, K; Hadi, Usman; Setiawan, Firman; Koendori, Eko Budi; Rusli, Musofa; Santosaningsih, Dewi; Severin, Juliette; Verbrugh, Henri A

    2016-01-01

    Epidemiological data of methicillin resistant Staphylococcus aureus (MRSA) carriage in Indonesian hospitals are still scarce. These data are required for health management of infectious diseases in order to control hospital MRSA. The carriage rate of MRSA in nose and throat of patients on admission to Dr Soetomo Hospital Surabaya, Indonesia was 8.1% of 643 patients, 5.4% from throat, 3.9% from nose and 1.2% from both sites. Prevalence of MRSA among patients admitted to surgical and non-surgical ward was not different (8.2% and 8.0%, respectively). Although MRSA prevalence in Indonesian hospitals is low compared to many other countries worldwide, appropriate health strategies will be needed to be implemented if this infection is to be controlled.

  13. The development of pediatric anesthesiology and critical care medicine at the Cincinnati Children's Hospital: an interview with Dr. Theodore Striker.

    PubMed

    Ahmed, Zulfiqar; Samuels, Paul J; Mai, Christine L; Rodriguez, Samuel; Iftikhar, Ahmed Raza; Yaster, Myron

    2015-08-01

    Dr. Theodore W. 'Ted' Striker (1936-), Professor of Anesthesiology and Pediatrics at the University of Cincinnati, has played a pioneering role in the development of pediatric anesthesiology in the United States. As a model educator, clinician, and administrator, he shaped the careers of hundreds of physicians-in-training and imbued them with his core values of honesty, integrity, and responsibility.

  14. Interacciones de galaxias en medios de diferente densidad a partir del catálogo SDSS DR2

    NASA Astrophysics Data System (ADS)

    Alonso, M. S.; García Lambas, D.; Tissera, P.; Coldwell, G.

    From the Sloan Digital Sky Survey, Data Release 2 (SDSS DR2), we construct a Catalog of 11274 pair galaxies with orbital parameters: rp< 100 kpc h-1 and Delta V < 350 km/sec. We analyze the star formation rate and colour indexes (u-r), (g-r) as a funcion of the orbital parameters in different environments. At low separation between pair members there is an important increase in the star formation activity and the fraction of blue colour indexes, which indicates that interactions are responsible of triggering SFR, increasing the young stellar population. The triggering of star formation by tidal torques seems to be more efficient in low density environments

  15. Cost of hospital care for HIV/AIDS infected patients in three general reference hospitals in Lubumbashi, DR Congo: prospective cohort study

    PubMed Central

    Tshamba, Henri Mundongo; a Kaut, Clarence Mukeng; Kyalubile, Nono Mulubwa; Kakambal, Alphonse Kaij; Yav, Grevisse Ditend; Kaj, Françoise Malonga; Vancaillie, Didier

    2013-01-01

    Introduction This article analyses the composition of healthcare costs for HIV/AIDS infected patients in a country with limited resources and attempts to identify the factors that influence these costs. The aims are to calculate medical care costs, analysing how they vary depending on patients’ income, and to evaluate the factors explaining healthcare consumption. Methods This is a prospective cohort study focusing on patients who were admitted to hospital for a short stay between January 2010 and June 2011, before their integration into a specialised program. The patients were selected randomly. Free consent was obtained from all participants. Data were analysed using the SPSS 19.0 software. The significance threshold was set at 5% and the CI (Confidence Interval) at 95%. We used Kruskal-Wallis tests, Fisher's exact test and multiple linear regression. Results We monitored 209 patients. Their average age was 36.37 years (SD: 8.72). The sex ratio was 0.58 and the women patients were generally younger than the male ones (p=0.011). The overall cost of healthcare amounted to $US 41,922. The cost of Antiretroviral Therapy represented 21.6% ($US 9,045). The price of para-clinical examinations represented 46% ($US 19,136) of the overall cost. The patient's average monthly income was $US 157.40 whereas the average direct cost per patient was$US 201.45. Both monthly income (t=4.385; p=0.0000) and education level (t=3.703 p=0.0003) were statistically significant predictive factors for healthcare consumption. The medical care costs for patients with opportunistic infections were nine times higher than those for patients who presented none. The presence of opportunistic infections increased healthcare consumption by approximately 31$ US (CI 95%: 15-46.9). Conclusion The average direct cost for patients on each short-term stay was higher than the average monthly income. To be able to access the necessary services, the patients need additional resources, which are derived

  16. Dr. Wernher Von Braun with Dr. Christian Barnard.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Christian Barnard Tours Marshall Space Flight Center. Shown in Dr. Von Braun's office are (left to right): Dr. Ernst Sthulinger, a representative from General Electric, Dr. Wernher Von Braun, Dr. Christian Barnard, and Dr. Eberhard Rees.

  17. Approaches to substance abuse in Cuba: Ricardo A. González MD PhD DrSc. Psychiatrist and consulting professor, Eduardo B. Ordaz Psychiatric Hospital, Havana. Interviewed by Christina Mills.

    PubMed

    González, Ricardo

    2013-10-01

    For over 40 years, he has done one of the most difficult jobs in medicine; 4000 of his patients are among those many might write off as "lost causes." Yet he radiates optimism, his stories and experience reflecting a belief in the human potential to change and grow and a vocation to help his patients do so. Now an internationally recognized expert on addictions, in 1976 Dr González founded Cuba's first patient service for substance abuse at the Eduardo B. Ordaz Psychiatric Hospital in Havana, a program he directed until last year. It is now the national reference center for another 17 such programs, two more in Havana and one in every other Cuban province. In addition, it serves as a model for treatment centers catering to international patients (undoubtedly the most well known among them Diego Maradona, the Argentine soccer star): two in Holguin Province and one in Santiago Province, with another being developed at Las Praderas International Health Center in Havana. Dr González's 25 books on psychiatry, medical ethics and addictions attest to a prolific career in research and practice. Today, he continues to work "from retirement" as consulting professor and psychiatrist in the addiction service he founded, and also chairs Cuba's National Medical Ethics Commission. In this interview, Dr González shares insights from his years of experience addressing substance abuse, as well as on repercussions and management of such conditions in Cuba.

  18. Dr Edward Macgowan (1795-1860), a long-term pioneer physician in mid-nineteenth century Jerusalem: founder and director of the first modern hospital in the Holy Land.

    PubMed

    Lev, Efraim; Perry, Yaron

    2008-02-01

    At the age of 46, Dr Edward Macgowan, by now a well-established physician, joined the ranks of the London Society for Promoting Christianity among the Jews with the aim of establishing the first modern hospital in Palestine. For the first six months of 1842, Macgowan established his work among the Jerusalem population on a regular basis and managed to establish a close relationship with the Jewish community and some of its leaders in Jerusalem. On 12 December 1844, the Jews' Hospital was opened in Jerusalem and became a source of great pride for the missionaries. Edward Macgowan died in Jerusalem after 18 years of service and was buried in the Protestant cemetery in his beloved city.

  19. The past, present, and future of paediatric cardiology training at the Johns Hopkins Hospital, in the tradition of Dr Helen Taussig.

    PubMed

    Beasley, Gary S; Murphy, Anne M; Brenner, Joel I; Ravekes, William J

    2016-12-01

    Johns Hopkins has been a leader in paediatric cardiology for over 85 years. In the 1940s, Dr Helen Taussig began training fellows in paediatric cardiology at Johns Hopkins at a time when the diagnosis and treatment of CHD were in the earliest stage. Under her leadership, the fellowship developed a strong foundation that has continued to evolve to meet the current needs of learners and educators. In the current era, the Johns Hopkins programme implements the current theories of adult education and actively engages our fellows in learning as well as teaching. The programme uses techniques such as flipped classroom, structured case-based small-group learning, observed and structured clinical examination, simulations, and innovative educational technology. These strategies combined with our faculty and rich history give our fellows a unique educational experience.

  20. Large Customers (DR Sellers)

    SciTech Connect

    Kiliccot, Sila

    2011-10-25

    State of the large customers for demand response integration of solar and wind into electric grid; openADR; CAISO; DR as a pseudo generation; commercial and industrial DR strategies; California regulations

  1. [Prioritization of the main health problems having impact upon the activity of the Emergency Military Hospital "Dr. Iacob Cihac" of Iaşi in the years 1995-2003].

    PubMed

    Maria Liliana, Iliescu; Botez, C; Zanoschi, Georgeta

    2005-01-01

    The various health problems that are faced by a hospital institution at any given point in time, compete for the usually limited resources that are available, while the health needs are infinite.Therefore, the prioritization process is a key to a functional activity. The prioritization method involves the formal selection criteria and system used to prioritize the health conditions. The Hanlon method is a quality one, and considers the following criteria: the magnitude of the problem, the severity of the problem, the predicted effectiveness of the intervention, and the feasibility of intervening to address the problem. This method requires a technique to allocate a score for each criterion and each health condition. According to hospitalized morbidity rates registered between 1995-2003, using prioritization method, we detected the main causes to address for improving the activity of Emergency Military Hospital "Dr. Iacob Cihac" Iaşi through a better selection of the inpatients and primary health care and community involvement. The presentation of the results situated on the top cardiovascular diseases, and on the last place the bone and articular diseases.

  2. CONHECIMENTO DA LEI GERAL DE SAÚDE – RESPEITO ÀS TRANSFUSÕES SANGUÍNEAS EM MÉDICOS E PACIENTES TESTEMUNHAS DE JEOVÁ DO HOSPITAL DR. DARÍO CONTRERAS DA REPÚBLICA DOMINICANA

    PubMed Central

    SANTANA, ELSA DÍAZ

    2010-01-01

    Este estudo avalia quanto o corpo médico do Hospital Dr. Darío Contreras de República Dominicana conhece, respeita, informa e aplica a Lei Geral de Saúde em relação aos direitos do paciente Testemunha de Jeová de negar-se a ser transfundido (respeito a sua autonomia); também se os Testemunhas de Jeová conhecem a Lei Geral de Saúde e até que ponto têm se beneficiado diante dessa proposição. O estudo revelou que nem médicos, nem Testemunhas de Jeová conhecem de fato essa lei. PMID:20689657

  3. Dr. Barnett's dream

    SciTech Connect

    Wilson, A.

    1990-04-01

    In 1986, AstroPower was a tiny R D company located at the University of Delaware. Like many other entrepreneurs in the field at that time, the company's president, Dr. Allen Barnett, had a good idea, a good research staff, and the dream of becoming a successful manufacturer of photovoltaic (PV) cells. If the Newark, Del. company's projections remain on track, Barnett plans to become the third largest PV manufacturer in the United States by the end of next year. Were it not for the company's performance to date, such a claim might well be dismissed as idle dreaming. AstroPower Inc. is pursuing a two-pronged strategy: to rapidly bring a new thin-crystal silicon PV cell to commercialization; and, in the meantime, to gain experience in manufacturing and distributing conventional single-crystal and polycrystal silicon cells. The company sold approximately 200 kilowatts (kWp) of cells last year (about half single-crystal and half polycrystal). Its current production capacity is 360 kWp. The company and its products are described.

  4. [Registry of myocardial infarction in a tertiary hospital of the Instituto Mexicano del Seguro Social].

    PubMed

    González-Pliego, José Angel; Gudiño-Amezcua, Diego Armando; Celis, Alfredo; Gutiérrez-Díaz, Gonzalo Israel

    2014-01-01

    Introducción: dado que el pronóstico de infarto del miocardio con elevación del segmento ST (IMCEST) depende de su manejo inmediato y de las medidas de prevención secundaria, el no seguir las recomendaciones actuales impide mejorar las expectativas de la población afectada por este padecimiento. El objetivo es describir el perfil clínico-epidemiológico y el proceso de atención del IMCEST en un hospital de tercer nivel. Métodos: se analiza la información clínica, la estratificación de riesgo, la terapia de revascularización y los hábitos de prescripción al egreso de los casos con IMCEST atendidos en un año. Resultados: se incluyeron 246 pacientes con edad promedio de 61 años; el 76 % fueron varones. La mayoría (37.3 %) de IMCEST ocurrió entre los 60 y los 69 años. El sedentarismo fue el factor de riesgo predominante. El 81.7 % de los casos tuvo score TIMI de riesgo bajo. El 35 % tuvo isquemia/viabilidad y en todos los cateterizados se demostraron obstrucciones coronarias. El 76 % se revascularizó con stent, principalmente farmacológico (77.5 %). Al egreso más del 90 % de los casos recibió estatina y antiplaquetarios, mientras otras drogas se prescribieron al 64-82 % de los casos. Conclusiones: el IMCEST predomina en hombres sedentarios de la séptima década. Estratificar el riesgo, buscar isquemia/viabilidad residual y revascularizar con stent farmacológico son prácticas comunes; el cumplimiento de recomendaciones basadas en la evidencia es mejor que en el pasado, pero todavía no es óptimo.

  5. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Thomas Paine, Deputy Administrator of the National Aeronautics and Space Administration, examines an ordinary man's shoe outfitted for use in the Saturn I workshop. Pictured from the left in the Saturn I workshop mockup are William Brooksbank, propulsion and vehicle engineering laboratory; Dr. Paine; Dr. Wernher Von Braun, Marshall Center director; Colonel Clare F. Farley, Executive Officer in the Office Of The Administrator; and Charles J. Donlan, Deputy Associate Administrator for Manned Space Flight, Technical. the shoe Dr. Paine is holding has a unique fastener built into the sole to allow an astronaut to move about on the workshop floor and to remain in one position if he desires.

  6. Dr. Daniel Carter

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Dr. Daniel Carter, president of New Century Pharmaceuticals in Huntsville, Al, is one of three principal investigators in NASA's microgravity protein crystal growth program. Dr. Carter's experties is in albumins. Albumins are proteins in the bloodstream that transport materials, drugs, nutrients, and wastes. Photo credit: NASA/Marshall Space Flight Center

  7. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left) and Fred W. Kelley examine a ST-100 Stellar Instrument Platform in the astrionics lab. Dr. Von Braun, then deputy associate administrator for planning, NASA, was visiting on the anniversary of the establishment of the Marshall Space Flight Center.

  8. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Shown viewing the Apollo telescope mockup are, from left to right, Charles Donlan, deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Marshall Space Flight Center director; William Horton, astrionics lab; Dr. Thomas Paine, NASA deputy administrator; Warner Kuers, director of the ME lab.

  9. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the astronautics lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics lab.

  10. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for Planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the Astronautics Lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics Lab.

  11. [Dr. John Argyropulos (1410-1492)].

    PubMed

    Colović, Radoje

    2008-01-01

    Dr. John Argyropulos (Dr. John Argyropulus, Dr. John Argyropoulos) was the last but, along with Dr. John Hortazmen, the most well known professor of Medical School, founded in 1308 by the Serbian king Stefan Uro II Milutin at the Hospital of St. John the Baptist monastery in Constantinople. After the town fell to the Turkish hands, Dr. Argyropulos stayed at Peloponnesus from 1453 to 1456, when he moved to Italy, in which he spent the rest of his life. He is not important only for the Serbs, he is more important for the Greeks and particularly for the Italians and Italy, in which he spent the largest part of his life, in which he achieved the university education, taught the Greek philosophy, language and literature, as well as translated a number of Aristotle's works from old Greek to Latin and New Greek, wrote a number of poems, letters and notes and made a strong influence on a number of Renaissance humanists in Florence, Italy, as well as on a number of intelectuals throghout Europe. We found no evidence that Dr. John Argiropulos either practised medicine in Italy, or that he taught medicine at the Italian medical schools.

  12. Afebrile pneumonia (whooping cough) syndrome in infants at Hospital Universitario del Valle, Cali, 2001-2007

    PubMed Central

    Villegas, Dolly; Echandía-Villegas, Connie Alejandra

    2012-01-01

    Introduction: Afebrile pneumonia syndrome in infants, also called infant pneumonitis, pneumonia caused by atypical pathogens or whooping cough syndrome is a major cause of severe lower respiratory infection in young infants, both in developing countries and in developed countries. Objective: To describe children with afebrile pneumonia syndrome. Methods: Through a cross-sectional study, we reviewed the medical records of children diagnosed with afebrile pneumonia treated at Hospital Universitario del Valle, a reference center in southwestern Colombia, between June 2001 and December 2007. We obtained data on maternal age and origin, prenatal care, the childs birth, breastfeeding, vaccination status, symptoms, signs, diagnosis, treatment, and complications. Results: We evaluated 101 children with this entity, noting a stationary presentation: June-August and November- December. A total of 73% of the children were under 4 months of age; the most common symptoms were: cyanotic and spasmodic cough (100%), respiratory distress (70%), and unquantified fever (68%). The most common findings: rales (crackles) (50%), wheezing and expiratory stridor (37%); 66% were classified as mild and of the remaining 33%, half of them required attention in the intensive care unit. In all, there was clinical diagnosis of afebrile pneumonia syndrome in infants, but no etiologic diagnosis was made and despite this, 94% of the children received macrolides. Conclusions: These data support the hypothesis that most of these patients acquired the disease by airway, possibly caused by viral infection and did not require the indiscriminate use of macrolides. PMID:24893051

  13. ["Del governo tecnico sanitario degli Ospedali" (Italian) ("Hospital governance") by E. Ronzani (1877-1943)- Padua (Italy), 1910].

    PubMed

    Renzulli, Lorenzo

    2014-01-01

    This article describes the contents of the first edition of the Italian textbook "Del governo tecnico sanitario degli ospedali" ("Hospital Governance") written by Prof. Enrico Ronzani (1877- 1943) and published in Padua (Italy) in 1910. The textbook contains a a preface by Prof. A. Serafini. Prof. Ronzani, a lecturer in Hygiene and health in 1910, introduced the first university course in "Hygiene and hospital technique" in Italy, in Padua in the academic year 1910-1911. The book focuses principally on the duties and responsibilities inherent in the role of the medical director.

  14. Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Dr. von Braun is looking out from a 10th floor window of building 4200 at the Marshall Space Flight Center (MSFC). He was the first Center Director and served as the Director from July 1960 through February 1970. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under the Project Paperclip (American acquisition of German rocket experts) to continue their rocket development work. In 1950, von Braun and his German Rocket Team (also called the Peenemuende Team) were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center (MSFC). Under Dr. von Braun's leadership, MSFC developed the Saturn V launch vehicle, which placed the first men, two American astronauts, on the Moon. Wernher von Braun's life was dedicated to expanding man's knowledge through the exploration of space.

  15. Dr. Eberhard Rees

    NASA Technical Reports Server (NTRS)

    1970-01-01

    Dr. Eberhard Rees served as director of the Marshall Space Flight Center from March 1, 1970 until January 19, 1973 when he retired from NASA. Prior to his appointment as Director, Rees served as the Center's deputy director under Dr. Wernher von Braun, 1960-1970. Rees came to the United States as part of the Dr. Wernher von Braun's German Rocket team following World War II. He transferred to Huntsville, Alabama from Fort Bliss, Texas in 1950 to work for the Army's rocket program at Redstone Arsenal. From 1956 to 1960 he served as deputy director of development operations at the Army Ballistic Missile Agency under von Braun. In 1960 Rees was transferred to NASA's Marshall Center.

  16. Dr Pugh: a poisoner?

    PubMed

    Paull, J D; Morris, G M

    2012-07-01

    On 16 February 1845 the Reverend W. H. Browne, rector of St John's Church in Launceston, Van Diemen's Land, wrote in his journal, "My dear Wife died very suddenly almost immediately after and in consequence of taking a preparation of Hyd. Cyan. Acid prepared & supplied by Dr Pugh". This journal entry raises a number of questions. Was Dr Pugh treating a condition which he thought merited that treatment or was it a ghastly mistake? Was Caroline Browne suffering from pulmonary tuberculosis? Was hydrocyanic acid an accepted treatment at that time? Did Mrs Browne take the wrong dose? Was an incorrect concentration of the drug prepared by Dr Pugh? Did he use the wrong pharmacopoeia in preparing the hydrocyanic acid? Why was there no inquest? Only some of these questions can be answered.

  17. Goldie Brangman Remembers the Operation to Save Dr King.

    PubMed

    Koch, Evan; Brangman, Goldie

    2015-12-01

    In September 1958 the Rev Dr Martin Luther King Jr was stabbed and nearly assassinated. Surgeons at Harlem Hospital in New York City removed a 17.8-cm (7-in)-long letter opener from Dr King's chest. Certified Registered Nurse Anesthetist Goldie Brangman remembers this event because she participated in Dr King's anesthetic. This article correlates Brangman's memories with published accounts of the event. It also places the event within the context of the modern civil rights movement that Dr King led.

  18. [Programme review of somatropin deficit in pediatrics at the Hospital Universitario Virgen del Rocío].

    PubMed

    Lavaredas, A; de la Puerta, R; Álvarez del Vayo, C

    2013-01-01

    Objetivo: Elaborar una revisión del programa de déficit de somatropina aplicado en pediatría en el Hospital Universitario Virgen del Rocío, utilizando dos grupos de pacientes, los diagnosticados con déficit de esta hormona y los nacidos pequeños para edad gestacional, con la intención de evaluar su efectividad en el primer año de tratamiento. Método: Realización de un estudio retrospectivo de la cohorte de pacientes en tratamiento con la hormona del crecimiento bajo los diagnósticos mencionados, con metodología observacional y transversal, a los cuales se aplicó un análisis estadístico con el programa Statistical Package for Social Sciences®. Resultados: Tras inicio del tratamiento la velocidad de crecimiento y la talla aumentaron y la edad ósea se aproximó a la edad cronológica. En los dos grupos tratados, en el primer año de tratamiento fueron los pacientes del sexo femenino con edad comprendida entre los 0 a 12 años con déficit de la hormona del crecimiento que respondieron mejor a la terapéutica establecida. Conclusiones: Pudimos observar que el tratamiento instituido se presentó altamente efectivo en ambos grupos de pacientes, permitiendo obtener un aumento favorable de estatura.

  19. Interview: Dr. Nathan Hare.

    ERIC Educational Resources Information Center

    Pete, Gregory

    1986-01-01

    Presents an interview with Dr. Nathan Hare, who proposes to address some of the problems of lower class, Black male youth by developing a formally supervised ritual to initiate the Black boy into adult male maturity and asserts that materialism prevents rather than promotes success. (KH)

  20. Dr. Goddard Transports Rocket

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Dr. Robert H. Goddard tows his rocket to the launching tower behind a Model A Ford truck, 15 miles northwest of Roswell, New Mexico. 1930- 1932. Dr. Goddard has been recognized as the 'Father of American Rocketry' and as one of three pioneers in the theoretical exploration of space. Robert Hutchings Goddard was born in Worcester, Massachusetts, on October 15, 1882. He was a theoretical scientist as well as a practical engineer. His dream was the conquest of the upper atmosphere and ultimately space through the use of rocket propulsion. Dr. Goddard, who died in 1945, was probably as responsible for the dawning of the Space Age as the Wright Brothers were for the begining of the Air Age. Yet his work attracted little serious attention during his lifetime. When the United States began to prepare for the conquest of space in the 1950's, American rocket scientists began to recognize the debt owed to the New England professor. They discovered that it was virtually impossible to construct a rocket or launch a satellite without acknowledging the work of Dr. Goddard. This great legacy was covered by more than 200 patents, many of which were issued after his death.

  1. Ask Dr. Sue.

    ERIC Educational Resources Information Center

    Aronson, Susan S.

    1990-01-01

    Discusses the need for child care providers to be sure children in their care who are between the ages of 15 months and 5 years have had Haemophilus influenzae type b (Hib) vaccine. Urges child care center staff to avoid use of bean bag infant cushions and to inform parents about the hazards posed by the cushions. (DR)

  2. 1. View of three detection radar (DR) antennas. DR 1 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View of three detection radar (DR) antennas. DR 1 (structure no. 735) on left, DR 2 (structure no. 736) in center, and DR 3 (structure no. 737) looking north 30 degrees west, with tracking radar (large radome) and satcom (satellite communication) system in small radome in view between DR 2 and DR 3 antennae. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  3. Dr. Timothy Hammond

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Dr. Timothy G. Hammond of the Department of Internal Medicine, Nephrology Section, Tulane University Medical Center, New Orleans, LA, is one of NASA's principal investigators conducting research with the NASA Bioreactor project directed by Johrnson Space Center. Hammond's investigations include Production of 1-25- diOH D3 by Renal Epithelial Cells in Simulated Microgravity Culture and Differentiation of Cultured Normal Human Renal Epithelial Cells in Microgravity. Photo credit: Tulane University.

  4. Dr. Faustus: Theist or Atheist?

    ERIC Educational Resources Information Center

    Karim, Shah Mohammad Sanaul; Fathema, Fawzia; Hakim, Abdul

    2015-01-01

    Dr. Faustus is the greatest but the most controversial of Marlowe's plays. Among the causes of controversy, whether Dr. Faustus is an atheist or theist deserves utmost attention. This paper is intended to deal with the issue. Though at various stages of the development of the action, Dr. Faustus abjures Trinity, resorts to necromancy, becomes…

  5. Hospital marketing.

    PubMed

    Carter, Tony

    2003-01-01

    This article looks at a prescribed academic framework for various criteria that serve as a checklist for marketing performance that can be applied to hospital marketing organizations. These guidelines are drawn from some of Dr. Noel Capon of Columbia University's book Marketing Management in the 21st Century and applied to actual practices of hospital marketing organizations. In many ways this checklist can act as a "marketing" balanced scorecard to verify performance effectiveness and develop opportunities for innovation.

  6. Dr. Rocco A. Petrone

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Dr. Rocco A. Petrone served at director of the Marshall Space Flight Center from January 26, 1973 to March 15, 1974. Prior to his tenure at Marshall, Petrone served as director of the Apollo program and director of launch operations at Kennedy Space Center. His career in rocket development and space programs began with his participation in the development of the Redstone missiles at the Army's Redstone Arsenal in Huntsville, Alabama. Upon his departure from Marshall, Petrone served as NASA Associate Administrator for Center Operations.

  7. Three MSFC Directors; Dr. Petrone, Dr. Rees, and Dr. von Braun

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Three Marshall Space Flight Center (MSFC) Directors: at left, Dr. Rocco A. Petrone (1973-1974), who had been named to succeed Dr. Rees, then-present director (Center); Dr. Eberhard Rees (1970-1973); and past director (right), Dr. Wernher von Braun (1960-1970). This photo was taken at the Redstone Arsenal Officers Club where over three hundred people had gathered to honor the career of Dr. Rees which sparned more than thirty years in rocketry and space exploration and wish him well upon his pending retirement on January 26, 1973.

  8. A pioneering female neurosurgeon: Dr. Aysima Altinok.

    PubMed

    Balak, N; Elmaci, I

    2007-01-01

    This article will look at how one female neurosurgeon in Turkey made her mark in the field. In 1954, Dr. Aysima Altinok began her residency training in neurosurgery at Haydarpaşa Numune Hospital where the first official department of neurosurgery in Turkey had been founded five years earlier. On November 22, 1959, she successfully completed her training and was certified officially as a neurosurgeon. Hence, Dr. Altinok was a leader in neurosurgery. Dr. Altinok was the chief of the department of neurosurgery from 1968 to 1992 at Bakirköy Mental and Psychological Health Hospital in Istanbul. She was among the founders of the Turkish Neurosurgical Society in 1968 and was awarded the honour of "Medical Doctor of the Year in Turkey" by the Ministry of Health in 1990. On May 15, 1996, she was accepted as an honorary member of Turkish Society of Neurosurgery for her contributions to neurosurgery. For proving the capability of a woman as a neurosurgeon, her contribution to the world history of neurosurgery should be respected.

  9. Introduction of Dr. Andrew V Schally

    PubMed Central

    Mendoza-Valdés, Arturo

    2015-01-01

    I first met Dr. Andrew V Schally (PhD, MDhc (Multi), DSc, Distinguished Medical Research Scientist, U.S. Department of Veterans Affairs Professor of Pathology and Department of Medicine,
Miller School of Medicine, University of Miami, Miami, Florida, USA) many years ago, probably around the beginning of the 1990's in one of his visits to Mexico City (Figure 1). He has many friends in my country since some of the investigations that led to the development of the LHRH agonists were made in a couple of Mexican hospitals in collaboration with some outstanding Mexican physicians that I will mention later. In that time, I was the head of the Department of Urology of the Mexican National Cancer Institute and our Director, Dr. Jaime de la Garza, invited him for a meeting. I was surprised by his humbleness, intelligence and easy going personality, in spite of being a Nobel Prize scientist. PMID:26112485

  10. Teaching Peace with Dr. Seuss.

    ERIC Educational Resources Information Center

    Pace, Rosemarie; Podesta, Andrea

    1999-01-01

    Educators seeking novel ways to instill conflict-resolution skills in young children should consider Dr. Seuss, whose books provide a synthesis of fantasy and reality that works for teaching values endemic to peace education. This paper discusses how students can learn peace and educators can teach peace using Dr. Seuss books, examining steps to…

  11. 5. View of middle DR 2 antenna with DR 1 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. View of middle DR 2 antenna with DR 1 antenna in background. Photograph shows on left side at bottom foundation berm and along right side bottom stanchion concrete foundations at bottom structural steel assembly. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  12. Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994

    SciTech Connect

    1995-07-01

    Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine treatment of diffuse toxic goiter (myxedema), the radiophosphorus and radioiodine programs with Dr. Bert Low-Beer, and treatment of polycythemia vera.

  13. Dr. Millie Cleveland: chiropractic achiever.

    PubMed

    Nash, J

    1998-06-01

    Dr. Mildred Genoa Allison-Cleveland, affectionately known as "Dr. Millie," was an important part of life at Cleveland Chiropractic College for over thirty years, serving first as a clerical assistant, then instructor, administrative assistant, and trusted right hand of her husband, Dr. Carl Cleveland, Jr. Yet Mildred Cleveland, like many other women who have helped the profession grow and survive over the years, has never been the subject of an article in print. In this paper, the author will strive to outline Dr. Mildred Cleveland's accomplishments, as well as to give the reader as clear a picture as possible of the woman who was the wife of one chiropractic pioneer and mother of another.

  14. Remembering Dr. Frederick Griffith Pearson

    PubMed Central

    Finley, Richard J.

    2016-01-01

    Summary Canada has lost a remarkable surgeon and leader. Dr. Frederick Griffith “Griff” Pearson, aged 90, died in Kitchener, Ont., on Aug. 10, 2016, surrounded by his wife, Hilppa Pearson, and his family. PMID:28234612

  15. [Dr Erwin Treu--the first permanent ophthalmologist in Split].

    PubMed

    Ivanisević, Milan; Bojić, Lovro; Bućan, Kajo; Kovacić, Zeljko

    2009-01-01

    Dr. Erwin Treu (Kotor, 1875-Skopje, 1937) was the first permanent ophthalmologist in Split, Croatia. He finished his ophthalmological specialization at the Eye Clinic in Prague in 1900 at W.P. Czermak. He originates from Tirol. Dr. Treu led and organized ophthalmological service in Split and worked from 1902 to 1921 in the Split Hospital, and had a private practice until 1923. From 1904 to 1910 he temporarily worked outside Split, in Sibenik, Zadar, Dubrovnik, Kotor and Cetinje. During the First World War he was a military doctor in Split and Trogir. He performed ophthalmological operations, cataracts, glaucomas (iridectomy), strabismus (tenotomies), ocular adnexa, injuries, trachoma etc. In 1923 he left for Skopje where he at first worked as a medical major in Military Hospital, and after that as a primarius in Civil Hospital at the Department of Ophthalmology till the end of his life.

  16. [Radiological percutaneous gastrostomy (GRP), 17 años de experiencia, serie de casos del hospital Universitario Virgen del Rocío].

    PubMed

    Navarro Falcón, Magnolia Del Carmen; Parejo Campos, Juana; Pereira Cunill, José Luis; García Luna, Pedro Pablo

    2014-10-25

    When assessing a patient nutritional support the state of the gastrointestinal tract is the most important point to consider, whenever possible we should choose the enteral nutrition (EN) over parenteral nutrition (PN) and recognized by its various advantages. The percutaneous gastrostomy (GRP) were introduced in clinical practice as an alternative to surgical gastrostomy (GQ). The speed, simplicity, low cost, low morbidity and low mortality of these techniques has allowed its rapid development.The feeding tubes types used were the balloon-retained devices catheter, the pig tail and the ballon-retained with gastropexia (gastropexia). It is a retrospective study of all patients who were placed GPR in the Virgen del Rocío University Hospital, Sevilla, between September 1996 and September 2013, which aims to study is to describe the characteristics of patients and the complications presented for different types of enteral feeding tubes used. GPR 186 were performed in 176 patients (135 males (76.70%), with an average duration of 303.6 days, the most frequent diseases were cancers of the head and neck 49.46%. The types of feeding tubes used were pigtail 118 (63.44%), balloon-retained devices 22 (11.83%), and gastropexia 46 (24.73%). The most common early complications in the pigtail group were early purulent exudate and early bleeding (2.5 and 3.4% respectively), while in the balloon catheter group the initial output of the probe was most frequent early complication (13.7%), none of these complications were observed in the group of gastropexy. The most common late complication was obstruction probe. The GPR is a safe technique with lower mortality of 1%; Low frequently of early and late complications. A better understanding of this technique can reduce the frequency of complications.

  17. Dr. John Richardson: Arctic Doctor

    PubMed Central

    Houston, C. Stuart

    1988-01-01

    Dr. John Richardson was foremost among a special breed of men, the surgeon-naturalists, one of whom accompanied every exploration party sent out by Great Britain. In addition to performing medical duties, the surgeon-naturalist was expected to identify and collect specimens of plants, animals, and rocks. Dr. Richardson was a member of two of the arctic expeditions led by Sir John Franklin, and participated in the search for the long-overdue third Franklin expedition. ImagesFigure 1 PMID:21253036

  18. Dr. von Braun With Management Team

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Dr. von Braun is shown in this photograph, which was probably taken in the early 1960s, with members of his management team. Pictured from left to right are, Werner Kuers, Director of the Manufacturing Engineering Division; Dr. Walter Haeussermarn, Director of the Astrionics Division; Dr. William Mrazek, Propulsion and Vehicle Engineering Division; Dr. von Braun; Dieter Grau, Director of the Quality Assurance Division; Dr. Oswald Lange, Director of the Saturn Systems Office; and Erich Neubert , Associate Deputy Director for Research and Development.

  19. SDSS DR2 Merging pairs

    NASA Astrophysics Data System (ADS)

    Allam, S. S.; Tucker, D. L.; SDSS Collaboration

    2004-05-01

    We present and analyze a catalog of 9,000 Merging pairs candidates to g=21 from the imaging data of the Sloan Digital Sky Survey (SDSS) Second Data Release (DR2). Candidates were selected using an automated algorithm (Allam et al. 2004) that is efficient in its selection of galaxy pairs. We highlight possible science applications of such a large photometric sample of merging pais and discuss future improvements, including incorporating magnitudes and pushing to higher redshifts and fainter pairs.

  20. FOREWORD: Dr Trevor J Hicks Dr Trevor J Hicks

    NASA Astrophysics Data System (ADS)

    Goossens, Darren

    2009-03-01

    This issue of Journal of Physics: Condensed Matter has been assembled to recognize the valuable contribution of Dr Trevor J Hicks to the field of neutron scattering and magnetism. Trevor began his study of magnetism as a PhD student at Monash University in Melbourne in the early 1960s, working with Professor Jack Smith. From the very beginning magnetism in alloys, and disordered systems in general, became a key aspect of his career. After a postdoctoral position at Harwell working with Dr Graeme Low Trevor returned to Australia and took up a position with Monash. He soon became a key figure in developing the capability for neutron scattering using the HIFAR reactor at the Australian Atomic Energy Commission, now the Australian Nuclear Science and Technology Organisation, ANSTO. The instrumentation was always developed to further his studies of magnetism. The development of polarization analysis measurements of diffuse magnetic scattering, first using iron filters and then his own design of supermirror benders for beam polarization, took place through the 1970s, 1980s and into the 1990s. Throughout this time, Trevor mentored a series of PhD students and postdoctoral fellows, many of whom have contributed to this issue (and, indeed, guest edited it). As befits a scientist and university academic for whom teaching has always been important, Trevor has not only created a strong body of significant research, he has also made a major contribution to preparing several generations of neutron scattering scientists, and this issue reflects that. When I approached Journal of Physics: Condensed Matter with a proposal for an issue in honour of Trevor, the response was immediate and positive. It is with great pleasure that I present the result of that proposal. The great diversity of the content, all centred on neutron scattering and magnetism, reflects the breadth of Trevor's own career and of the scientists with whom he has interacted. Finally, I would like to make some

  1. [Dr. John Baptiste Edouard Gélineau].

    PubMed

    Janković, S; Susić, V; Sokić, D; Lević, Z

    1996-01-01

    became the "Intern" of the Navy Hospital and next year a "Surgeon of the Third Class". As a Navy surgeon he visited French colonies in the Indian ocean: first the Reunion island and then Mayotte island of the Commores Archipelago. Of this period he wrote "Voyage a i'lle de la Réunion", memoirs published much later, in 1905, in which he described colonial life and abolition of slavery. The story of Elise, a beauteous Creole woman, a concubine of a young naval Commander, who delivered a child that soon died, inexorably points to the autobiographic character of his work. He defended a doctoral thesis "Aperçu Medical de I'lle de Mayotte" at Montpellier University School of Medicine in 1858, using the data collected during his year-and-a-half stay on a Mayotte island; at that time he was a "Navy Surgeon of the Second Class". For his dedication in fighting against epidemics that broke out during the French-German war in 1870 he was nominated for the Legion of Honor, but received it only later. In 1871 Gélineau introduced "Doctor Gélineau's tablets" for the treatment of epilepsy (contained bromide and arsenic). He was a member of the Société de Médicine, Société d' Hypnologie, La-Société Française d' Hygiène, and a few others. After retirement at the age of 72, Gélineau switched to wine production, continuing the family tradition; for the quality of his Bordeaux wines he was awarded gold medals at the Anvers and Paris Exhibitions. Dr. Gélineau died on March 2, 1906, at Argeles Gazost in Pyrnees honored by the titles of Chevalier de la Légion d' Honneur, Officier d'Academie and Commander of Nichan of the Ottoman Empire.

  2. Dr. Harry Whelan With the Light Emitting Diode Probe

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The red light from the Light Emitting Diode (LED) probe shines through the fingers of Dr. Harry Whelan, a pediatric neurologist at the Children's Hospital of Wisconsin in Milwaukee. Dr. Whelan uses the long waves of light from the LED surgical probe to activate special drugs that kill brain tumors. Laser light previously has been used for this type of surgery, but the LED light illuminates through all nearby tissues, reaching parts of tumors that shorter wavelengths of laser light carnot. The new probe is safer because the longer wavelengths of light are cooler than the shorter wavelengths of laser light, making the LED less likely to injure normal brain tissue near the tumor. Also, it can be used for hours at a time while still remaining cool to the touch. The probe was developed for photodynamic cancer therapy under a NASA Small Business Innovative Research Program grant. The program is part of NASA's Technology Transfer Department at the Marshall Space Flight Center.

  3. SDSS DR7 superclusters. Morphology

    NASA Astrophysics Data System (ADS)

    Einasto, M.; Liivamägi, L. J.; Tago, E.; Saar, E.; Tempel, E.; Einasto, J.; Martínez, V. J.; Heinämäki, P.

    2011-08-01

    Aims: We study the morphology of a set of superclusters drawn from the SDSS DR7. Methods: We calculate the luminosity density field to determine superclusters from a flux-limited sample of galaxies from SDSS DR7 and select superclusters with 300 and more galaxies for our study. We characterise the morphology of superclusters using the fourth Minkowski functional V3, the morphological signature (the curve in the shapefinder's K1-K2 plane) and the shape parameter (the ratio of the shapefinders K1/K2). We investigate the supercluster sample using multidimensional normal mixture modelling. We use Abell clusters to identify our superclusters with known superclusters and to study the large-scale distribution of superclusters. Results: The superclusters in our sample form three chains of superclusters; one of them is the Sloan Great Wall. Most superclusters have filament-like overall shapes. Superclusters can be divided into two sets; more elongated superclusters are more luminous, richer, have larger diameters and a more complex fine structure than less elongated superclusters. The fine structure of superclusters can be divided into four main morphological types: spiders, multispiders, filaments, and multibranching filaments. We present the 2D and 3D distribution of galaxies and rich groups, the fourth Minkowski functional, and the morphological signature for all superclusters. Conclusions: Widely different morphologies of superclusters show that their evolution has been dissimilar. A study of a larger sample of superclusters from observations and simulations is needed to understand the morphological variety of superclusters and the possible connection between the morphology of superclusters and their large-scale environment.

  4. Dr. von Braun Briefing Walt Disney

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

  5. [Interview with Dr. Ricardo Bressani].

    PubMed

    1994-01-01

    In an interview Dr. Ricardo Bressani, a chemical engineer by profession and a consultant of the Institute of Nutrition of Central America and Panama (INCAP), talks about the search for a product later given the name of Incaparina, which was eventually developed for food supplementation programs by INCAP. Experiments were made with soybeans, cottonseed, and various cereals to arrive at the optimal mixture of 62% cereal and 38% protein for this product. In addition, vitamins and lysine were added. The major demand for this biscuit occurred between 1976 and 1978. Since that time sales have ebbed partly owing to the soaring commodity prices. Incaparina is sold in Guatemala and El Salvador and there are tests going on in Mexico, Colombia, and Cuba to produce it locally. This product is also proof of the benefit of developing leguminous cereal systems. The optimal combination is 70% cereals and 30% legumes, each providing 50% protein. The potential of mixing various other cereals and fruits are also being studied. A large number (up to 60 annually) of nutritional research papers are published on the national level and in Latin America in prestigious scientific journals whose monitoring calls for coordination between different authors.

  6. Dr Valter Rukavina - amateur painter.

    PubMed

    Glavocic, Daina

    2008-01-01

    In this essay Dr Valter Rukavina (Rijeka 1896-1972), excellent specialist in infectious diseases and professor of the Rijeka University School of Medicine, is presented as successful amateur painter. He had been refining his talent through relentless practice since the school days, complementing it with skills and advice from established painters he associated with. He favoured figurative, realistic and somewhat romantic expression for his themes such as coastal landscapes, marinas, Quarnero sceneries, still life in tempera or oil, and drawings in ink or sepia. Despite partial colour blindness, he successfully used colour. He featured in a number of group exhibitions such as that of amateur painters of Rijeka in 1950, of painters physicians of Yugoslavia (Zagreb, 1956), in the Second International Exhibition of Contemporary Art (Florence, 1964), exhibition of the Rijeka branch of the Croatian Association of Visual Artists (Belgrade, 1966), and the 1969 exhibition in Opatija. His native city hosted two one-man exhibitions, the first retrospective in 1971, while he was still alive, and the second posthumous in 2007, with a good selection of his life's work.

  7. An Interview with Dr. Robert W. Young.

    ERIC Educational Resources Information Center

    Silentman, Irene

    1996-01-01

    Dr. Robert W. Young discusses what led him to work in the Navajo Nation and to begin studying Navajo, the method he used for developing a Navajo orthography, his professional relationship with Dr. William Morgan, the system they used to develop an English-Navajo dictionary, his views on language loss, and his greatest accomplishment--a reservation…

  8. Dr. William Morgan: A Granddaughter's Remembrance.

    ERIC Educational Resources Information Center

    Henderson, Jennifer M.

    1996-01-01

    Dr. William Morgan, a Navajo linguist, devoted his career to the development and preservation of the Navajo language. Morgan collaborated with Dr. Robert Young in writing "The Navajo Language," an unabridged Navajo-English dictionary. He also taught Navajo at the Navajo Community College and worked for the Native American Materials…

  9. Dr. Wernher Von Braun at a picnic.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, director of the Marshall Space Flight Center, stakes claim to a table for the picnic celebrating man's first lunar landing. With Dr. Von Braun are his wife, Maria (seated, right), and son, Peter (back to camera). His daughter, Margrit, was also present, but is hidden from view by friends in this view.

  10. Dr. Wernher Von Braun greeting dignitaries.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, left, greets vice president Spiro T. Agnew in the Launch Control Center for the Apollo 14 mission. Between Dr. Von Braun and Mr. Agnew are their Royal Highnesses, The Prince and Princess of Spain. The royal visitors greeted the launch control team in th enter after the launch of Apollo 14.

  11. Dr. von Braun Tries Out the NBS

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Marshall Space Flight Center (MSFC) Director, Dr. von Braun, is shown fitted with suit and diving equipment as he prepares for a tryout in the MSFC Neutral Buoyancy Simulator (NBS). Weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

  12. Dr. von Braun Discusses 'Bottle Suit' Concept

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Wernher von Braun (center), then Chief of the Guided Missile Development Division at Redstone Arsenal, Alabama, discusses a 'bottle suit' model with Dr. Heinz Haber (left), an expert on aviation medicine, and Willey Ley, a science writer on rocketry and space exploration. The three men were at the Disney studios appearing in the motion picture, entitled 'Man in Space.'

  13. Letter to Dr. Felix Bronner

    NASA Technical Reports Server (NTRS)

    Greenleaf, John E.; Dalton, Bonnie (Technical Monitor)

    2002-01-01

    Dear Dr. Bronner: I have been reading in The Physiologist the letters from senior physiologists for many years with great interest. It is impressive that many of the respondents are still pursuing scientific endeavours in their 70's and some even in their 80's. The interesting task is to ponder the relative causative proportions of heredity and environment responsible. One wonders whether knowing something about physiology engenders longer and more productive lives? I suspect so because of the accompanying self-discipline. But another factor would seem to be the pervasive joy of working in this profession. I have been fortunate to be able to acquire the joy of physiology during my graduate studies at Illinois, and to have been able to carry it over here at NASA, Ames Research Center for the past 40 years. A truly academic style research environment at a federal research center is rare. The trick to a joyous research career is to overcome those ever-present slings and arrows of outrageous fortune with dignity whenever possible. To that end I have found solace and guidance in reading the history of warfare and its leaders, especially Sun Tsu's The Art of War and Clauswitz's On War. I became eligible for retirement in 1993, but to insure domestic tranquility and also the joy of pursuing my research hobby have continued working in the laboratory on human research. It is troubling to see that funding for individual scientists conducting human research is declining rapidly, along with their new ideas; perhaps the old ones are more comfortable. Hopefully I can provide a similar response when I'm 80! Thanks for your interest. Sincerely, John Greenleaf

  14. [Neuroblastoma: prognostic factors and survival. Experience in Hospital de Pediatria del Centro Medico Nacional del Siglo XXI and review of the literature].

    PubMed

    López-Aguilar, Enrique; Cerecedo-Díaz, Fernando; Rivera-Márquez, Hugo; Valdéz-Sánchez, Martha; Sepúlveda-Vildósola, Ana Carolina; Delgado Huerta, Sandra; Vera-Hermosillo, Herlinda; Vázquez-Langle, José Raúl; Wanzke del Angel, Volkmar

    2003-01-01

    Neuroblastoma (NB) is the most frequent extracranial solid tumor in children according to the literature. In Mexico it is less frequent, fallen to 8th place. Our objective was to analyze our experience and compare it with the one reported in other countries. We included all patients admitted to our hospital during the previous five years and who had not received any treatment. Patients with stages I, II, and IV received cyclophosphamide and epirrubicin. Patients with stages were III and IV received the same chemotherapy alternating with cisplatinum., ifosfamide and etoposide during 12 months as well as massive doses of 131-MIBG and surgical ablation of the remaining tumor when possible. We included 30 patients, 25 with initial presentation in the abdomen. Five were in early stages and 20 (70%) were advanced with an overall survival of 100% and 27% at 5 years respectively. When analyzed by age, 40% were 12 months of age and 60% older, with survival of 100% and 27% in the same period, respectively. According to histology there was 91% survival for differentiated and 23% for undifferentiated tumors. The chemotherapeutic regimen reported is effective but not better than that reported by other authors, in which some benefits are seen with use of transplant and immunotherapy. The most important prognostic factors are still considered to be age, stage and histology.

  15. Monocytic HLA DR antigens in schizophrenic patients.

    PubMed

    Krause, Daniela; Wagner, Jenny; Matz, Judith; Weidinger, Elif; Obermeier, Michael; Riedel, Michael; Gruber, Rudolf; Schwarz, Markus; Mueller, Norbert

    2012-01-01

    A genetic association of specific human leukocyte antigens (HLA) DR genes and schizophrenia has recently been shown. These HLA play a fundamental role in the control of immune responses. Furthermore infectious agents have been proposed to be involved in the pathogenesis of schizophrenia. In this study we investigated the rate of HLA DR positive monocytes in schizophrenic patients compared to controls with a special focus on the adaption to in vitro stimulation with toll-like receptor ligands. Patients with schizophrenia and matched controls were included. For each individual, we evaluated the rate of HLA DR positive monocytes (either incubated at 37 °C or after stimulation with lipopolysaccharide or Poly I:C). We found a significantly higher percentage of schizophrenic patients with elevated HLA DR positive cells (p=0.045) as compared to controls. The adjustment rate from baseline levels of monocytic HLA DR positive cells to stimulation with Poly I:C was significantly lower in schizophrenic patients (p=0.038). The increased monocytic HLA DR in schizophrenic patients and the maladjustment of their monocytic HLA DR levels to an infectious stimulus might be a sign for a disturbed monocytic immune balance in schizophrenic individuals.

  16. [Interculturality in the medical practice of Dr. Albert Schweitzer].

    PubMed

    Campos-Navarro, Roberto; Ruiz-Llanos, Adriana

    2004-01-01

    Albert Schweitzer (1875-1965) was a young and promising German who at age 29 decided to undertake the profession of Medical Doctor at the University of Strassburg after finishing a career in musical studies in Paris (1899) and obtaining in Berlin a doctoral degree in Philosophy and Theology. Surprisingly, Albert Schweitzer, despite his comfortable life in Europe, decided in 1913 to practice his medical career in a remote and small Equatorial African country. He devoted nearly 50 years of his life caring for the Black population at Lamaberene, where he built a hospital. In this paper, we attempt to develop some theoretical aspects related with interculturality in the medical practice of Dr. Albert Schweitzer. We begin by considering certain sociocultural variables in hospitals that give care to patients with cultural characteristics that are substantially different from those of the health care personnel who organize, administer, and execute medical functions.

  17. Dr. Robert H. Goddard and His Rockets

    NASA Technical Reports Server (NTRS)

    1926-01-01

    Dr. Robert H. Goddard and liquid oxygen-gasoline rocket in the frame from which it was fired on March 16, 1926, at Auburn, Mass. It flew for only 2.5 seconds, climbed 41 feet, and landed 184 feet away in a cabbage patch. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  18. [Cutaneous myiasis by Cochliomyia hominivorax (Coquerel) (Diptera Calliphoridae) in Hospital Universidad del Norte, Soledad, Atlántico].

    PubMed

    de la Ossa, Napoleón; Castro, Luis Eduardo; Visbal, Lila; Santos, Ana María; Díaz, Esther; Romero-Vivas, Claudia M E

    2009-03-01

    Human myiasis is the parasitism of human tissues by fly larvae. Diagnoses are based on clinical pattern of tissue damage and presence of insect stages. Herein, a case myiasis is described in a seven-year-old female child. She presented with fever associated with abscessed scalp lesions containing exposed larvae. Severe pediculosis was also observed. The patient was hospitalized and treated with clindamycin, gentamicin (for bacterial secondary infections) and ivermectin (treatment for lice) after which the patient showed clinical improvement and was discharged four days later. Since human myiasis can be caused by a number of different species, larvae were collected from the patient and identified as those of Cochliomyia hominivorax (Diptera: Calliphoridae). Because other cases of coinfestation of flies and lice are on record, health workers are to be alerted about the possible pediculosis-myasis risk.

  19. From the Field: Speech Therapy Outcome Measures--Interview with Dr. Pam Enderby

    ERIC Educational Resources Information Center

    Montgomery, Judy K.

    2015-01-01

    This article is an interview with Dr. Pam Enderby--a speech language therapist and professor at the Institute of General Practice and Primary Care at the University of Sheffield, Community Sciences Centre, Northern General Hospital, in the United Kingdom--conducted by Judy Montgomery, Editor in Chief, of "Communication Disorders…

  20. Dr. Francis Collins Is New NIH Director

    MedlinePlus

    ... concluded successfully in April 2003 with the complete map of the human genome, the instruction book for peoples' DNA. Dr. Collins is also known for discovering a number of important genes, including those responsible for cystic fibrosis, neurofibromatosis, Huntington's ...

  1. But Dr. Meisels Is Not Convinced.

    ERIC Educational Resources Information Center

    Meisels, Samuel J.

    1987-01-01

    Commenting on the Gesell Institute's response to his original article concerning the Gesell assessments, Dr. Meisels continues to maintain that the Gesell readiness tests lack sufficient proof of validity. (BB)

  2. Dr. Irvin Yalom Discusses Group Psychotherapy.

    ERIC Educational Resources Information Center

    Forester-Miller, Holly

    1989-01-01

    In this interview, Dr. Irvin Yalom, director of the Adult Psychiatry Clinic at Stanford University School of Medicine, discusses his beginnings as a group psychotherapist, current issues in group work, and the future of group work. (Author/TE)

  3. Dr. Sholom Wacholder - In their own words

    Cancer.gov

    Dr. Sholom Wacholder, a biostatistician in the NCI Division of Cancer Epidemiology and Genetics, discusses his role on a human papillomavirus vaccine clinical trial. From the archives of the NCI Cancer Bulletin - 2010.

  4. Dr. Robert H. Goddard and His Rocket

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Goddard rocket with four rocket motors. This rocket attained an altitude of 200 feet in a flight, November 1936, at Roswell, New Mexico. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  5. Childhood Picture of Dr. von Braun

    NASA Technical Reports Server (NTRS)

    1912-01-01

    This is a childhood picture of Dr. von Braun (center) with his brothers. Dr. Wernher von Braun was born in Wirsitz, Germany, March 23, 1912. His childhood dreams of marned space flight were fulfilled when giant Saturn rockets, developed under his direction at NASA's Marshall Space Flight Center, boosted the manned Apollo spacecraft to the Moon. His life was dedicated to expanding man's knowledge through the exploration of space.

  6. Dr. von Braun with Gen. Ostrander, Dr. Rees, and Gen. Barclay

    NASA Technical Reports Server (NTRS)

    1959-01-01

    In this 1959 photo, taken at Cape Canaveral, Florida, Dr. von Braun (2nd from left) Director of the U.S. Army Ballistic Missile Agency's (ABMA) Development Operations Division, is shown conferring with Air Force Major General Donald R. Ostrander (left), on assignment at NASA as launch vehicle director; Dr. Eberhard Rees, deputy to Dr. von Braun, and Army Brigadier General John Barclay, commander of the ABMA.

  7. Comparison of del Nido cardioplegia and St. Thomas Hospital solution – two types of cardioplegia in adult cardiac surgery

    PubMed Central

    Mishra, Prashant; Jadhav, Ranjit B.; Khandekar, Jayant; Raut, Chaitanya; Ammannaya, Ganesh Kumar; Seth, Harsh S.; Singh, Jaskaran; Shah, Vaibhav

    2016-01-01

    Introduction St. Thomas’ cardioplegic solution No. 2 (ST), although most widely used in adult cardiac surgery, needs to be given at short intervals, causing additional myocardial injury. Aim To determine whether del Nido (DN) cardioplegia, with longer periods of arrest, provides equivalent myocardial protection as compared to ST. Material and methods The study population comprised 100 patients who underwent elective coronary artery bypass grafting (CABG) or double valve replacement (DVR) surgery between January 2015 and January 2016. The patients were divided into two groups based on the type of cardioplegia administered during surgery: 1) intermittent ST (ST, n = 50) and 2) DN cardioplegia (DN, n = 50). We compared the aortic cross clamp (CC) and cardiopulmonary bypass (CPB) times, number of intra-operative DC shocks required, and postoperative changes in left ventricular ejection fraction (LVEF) in the two groups. Results The aortic cross clamp and bypass times were shorter with DN (110.15 ±36.84 vs. 133.56 ±35.66 and 158.60 ±39.92 vs. 179.81 ±42.36 min respectively, p < 0.05). Fewer cardioplegia doses were required in the DN group vs. the ST group (1.38 ±0.59 vs. 4.15 ±1.26; p = 0.001), while a single cardioplegia dose was given to 35 DN patients (70%) vs. 0 ST patients (p < 0.001). Postoperative LVEF was better preserved in the DN group. Conclusions The use of DN leads to shorter cross clamp and CPB times, reduces cardioplegia dosage, and provides potentially better myocardial protection in terms of LVEF preservation, with a safety profile comparable to ST cardioplegia. PMID:28096823

  8. [Incurable disease in Spain during the 19th century. The Hospital para Hombres Incurables Nuestra Señora del Carmen].

    PubMed

    Zaragoza, Juan Manuel

    2012-01-01

    This paper examines the State's assumption of medical care for patients with "permanent needs" in 19th century Spain. These patients were the incurably ill, the chronically ill and the elderly. This process is contextualized within the liberal reforms of the Spanish healthcare system in the reign of Isabel 11 (1833-1868). The goal of these reforms was the creation and consolidation of a national health system that would gradually replace the religious health charities. Healthcare reform became necessary due to the increase in migration that started in the 1830's and intensified in the 1850's. Traditional care networks formed by the family, local community and religious charities were no longer available to those who had left their village or town. In addition, many religious charities were bankrupted by the seizure of their properties in a programme of confiscation. Similar healthcare reform processes were taking place in the United Kingdom, France and Germany, among other European countries, and involved significant changes in the lives of patients, who became strictly controlled and medicalised. My aim was to identify changes in the patients' experience of illness through a case study of the living conditions of inmates at the Nuestra Señora del Carmen Hospital for Incurable Men, based in Madrid from 1852 to 1949. This was one of the institutions devoted to caring for patients with "permanent needs" and was under the direct control of the General State Administration.

  9. CancerDR: cancer drug resistance database.

    PubMed

    Kumar, Rahul; Chaudhary, Kumardeep; Gupta, Sudheer; Singh, Harinder; Kumar, Shailesh; Gautam, Ankur; Kapoor, Pallavi; Raghava, Gajendra P S

    2013-01-01

    Cancer therapies are limited by the development of drug resistance, and mutations in drug targets is one of the main reasons for developing acquired resistance. The adequate knowledge of these mutations in drug targets would help to design effective personalized therapies. Keeping this in mind, we have developed a database "CancerDR", which provides information of 148 anti-cancer drugs, and their pharmacological profiling across 952 cancer cell lines. CancerDR provides comprehensive information about each drug target that includes; (i) sequence of natural variants, (ii) mutations, (iii) tertiary structure, and (iv) alignment profile of mutants/variants. A number of web-based tools have been integrated in CancerDR. This database will be very useful for identification of genetic alterations in genes encoding drug targets, and in turn the residues responsible for drug resistance. CancerDR allows user to identify promiscuous drug molecules that can kill wide range of cancer cells. CancerDR is freely accessible at http://crdd.osdd.net/raghava/cancerdr/

  10. Geophysical survey of 105-DR Pluto Crib, 116-DR-4, 100-D Area

    SciTech Connect

    Bergstrom, K.A.

    1993-10-01

    The objective of this Geophysical Survey was to verify the location of the 105-DR Pluto Crib, 116-DR-4. A surface monument currently marks its location. The crib is 10 feet by 10 feet and 15 feet deep. Ground-Penetrating Radar was the geophysical method selected to conduct the investigation.

  11. Dr. Wernher von Braun Laid to Rest

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paper Clip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. Dr. von Braun died in Alexandria, Va., on June 16, 1977, seven years after his NASA appointment. This photo was taken at the site where he was laid to rest.

  12. The ORAC-DR data reduction pipeline

    NASA Astrophysics Data System (ADS)

    Cavanagh, B.; Jenness, T.; Economou, F.; Currie, M. J.

    2008-03-01

    The ORAC-DR data reduction pipeline has been used by the Joint Astronomy Centre since 1998. Originally developed for an infrared spectrometer and a submillimetre bolometer array, it has since expanded to support twenty instruments from nine different telescopes. By using shared code and a common infrastructure, rapid development of an automated data reduction pipeline for nearly any astronomical data is possible. This paper discusses the infrastructure available to developers and estimates the development timescales expected to reduce data for new instruments using ORAC-DR.

  13. The Old Library of the Pennsylvania Hospital *

    PubMed Central

    Bell, Whitfield J.

    1972-01-01

    The first medical book acquired by the Pennsylvania Hospital was William Lewis's Experimental History of the Materia Medica. Dr. John Fothergill of London donated it in 1762. The next year the Managers resolved to establish a library, and the physicians assigned their fees from hospital students for the purchase of books. Books were regularly ordered from William Strahan in London, and gifts and bequests added still more volumes. From 1790 to 1810 Dr. John Coakley Lettsom of London was the hospital's principal adviser on purchases. As the library grew, it expanded beyond purely medical works to include some in natural history, many purchased in 1817 from the estate of Dr. Benjamin Smith Barton. Catalogues were printed in the years 1790-94, 1806, 1829, and 1857. At midcentury the hospital library numbered about 9,000 volumes. At that time it was the largest medical library in the United States. PMID:4563538

  14. Chamber of Commerce reception for Dr. Lucas

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Dr. William R. Lucas, Marshall's fourth Center Director (1974-1986), delivers a speech in front of a picture of the lunar landscape with Earth looming in the background while attending a Huntsville Chamber of Commerce reception honoring his achievements as Director of Marshall Space Flight Center (MSFC).

  15. The Contributions of Dr. Alfred Gysi.

    PubMed

    Phoenix, Rodney D; Engelmeier, Robert L

    2016-11-24

    This article is a historical overview of Dr. Alfred Gysi's contributions to the profession in the areas of denture tooth and articulator design. His understanding of occlusion and mandibular movement resulted in denture tooth designs and occlusal concepts still in widespread use.

  16. The Years of Dr. Robert Eugene Marshak

    NASA Astrophysics Data System (ADS)

    Mo, Luke W.

    I am honored and privileged to make a brief statement in memory of Dr. Marshak's distinguished achievement in science, his kindness and great humanity. I will concentrate on the part of his career at Virginia Polytechnic Institute and State University …

  17. A TRIBUTE TO DR. WILLIAM PENN WATKINSON

    EPA Science Inventory

    Dr. William Penn Watkinson (known to colleagues as "Penn") of EPA¿s health research lab (National Health and Environmental Research Laboratory) of Research Triangle Park, North Carolina, died Wednesday, December 13 after a battle with lung cancer. He was a member of the Pulmonar...

  18. Interview [with Dr. Gerald W. Bracey

    ERIC Educational Resources Information Center

    Journal of Educational Research, 2007

    2007-01-01

    This article presents an interview with Dr. Gerald W. Bracey, author of "Reading Educational Research: How to Avoid Getting Statistically Snookered." During the interview, Bracey explains why he considers the No Child Left Behind Act (NCLB) as a "weapon of mass destruction" and that he sees nothing to suggest that NCLB has…

  19. Dr. Israel Cuellar (1946-2008)

    ERIC Educational Resources Information Center

    Zamarripa, Manuel X.

    2009-01-01

    On September 7th, 2008, the mental health field lost a trailblazing researcher and clinician as he lost his battle with amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrig's disease. Dr. Israel Cuellar made significant contributions to the study of acculturation including its importance in delivering appropriate mental health…

  20. Dr. Caleb Williams Saleeby: The Complete Eugenicist.

    ERIC Educational Resources Information Center

    Rodwell, Grant

    1997-01-01

    Profiles the work of Dr. Caleb Williams Saleeby, a late 19th-century propagandist for eugenics. Eugenics is a science that deals with the transmission of hereditary racial traits, coupled with a desire to use this for the elimination of social ills. Discusses Saleeby's work with the Eugenics Education Society. (MJP)

  1. Dr. Hugh L. Dryden - artist's sketch

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Artist's depiction of Dr. Hugh Latimer Dryden. Dr. Dryden saw his first airplane, the Antoinette, on November 7, 1910. Years later he was fond of remarking. 'The airplane and I grew up together.' In addition to his professional work, Dr. Dryden was a licensed preacher for 45 years. One of his later sermons perhaps best describes his legacy: 'None of us knows what the final destiny of man may be, or if there is any end to his capacity for growth and adaptation. Wherever this venture leads us, I am convinced that the power to leave the Earth -- to travel where we will in space and to return at will -- marks the opening of a brilliant new stage in man's evolution.' The honors, offices and awards bestowed on Hugh Dryden were great both in significance and in number. His honorary degrees numbered 16. In 1962 the Methodist Union named him the Methodist Layman of the Year. Dr. Dryden was initially an aerodynamicist with the National Bureau of Standards. He did important early work in high-speed aerodynamics. In 1947 he became the director of aeronautical research for the National Advisory Committee for Aeronautics (NACA -- predecessor of the National Aeronautics and Space Administration). Two years later, he became NACA's director, a position he held until 1958 when he became deputy administrator of NASA.

  2. Dr. Wernher Von Braun presents a certificate

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left), director of the Marshall Space Flight Center, presents a humorous certificate to Major General Charles W. Eifler, commanding general of Redstone Arsenal, at the close of a farewell luncheon for the general prior to General Eifler moving to a new European duty station.

  3. Dr. von Braun Visits Huntsville Boys Club

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Dr. von Braun, Director of Marshall Space Flight Center (MSFC) and chairman of this year's United Givers Fund (UGF) drive at MSFC, takes time out from the problems of sending a man to the Moon to talk baseball with 11-year-old Randy Smith at the Huntsville Boys Club.

  4. Walt Disney and Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Werhner von Braun, then Chief, Guided Missile Development Operation Division at Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama, was visited by Walt Disney in 1954. In the 1950's, von Braun worked with Disney Studio as a technical director, making three films about space exploration for television. A model of the V-2 rocket is in background.

  5. Dr. von Braun and Dr. Stuhlinger With a Model of the Nuclear-Electric Vehicles

    NASA Technical Reports Server (NTRS)

    2004-01-01

    In this photo, taken at the Walt Disney Studios in California, Dr. Wernher von Braun and Dr. Ernst Stuhlinger are shown discussing the concepts of nuclear-electric spaceships designed to undertake the mission to the planet Mars. As a part of the Disney 'Tomorrowland' series on the exploration of space, the nuclear-electric vehicles were shown in the last three television films, entitled 'Mars and Beyond,' which first aired in December 1957.

  6. Dr. John J. Stephens, Jr., metallurgist extraordinaire.

    SciTech Connect

    Hosking, Floyd Michael

    2010-10-01

    The organizers of the Dr. John J. Stephens, Jr. Memorial Symposium: Deformation and Interfacial Phenomena in Advanced High-Temperature Materials are honoring the memory of Dr. Stephens and his many technical contributions that were accomplished over a relatively brief twenty year career. His research spanned the areas of creep and deformation of metals, dispersion-strengthened alloys and their properties, metal matrix composite materials, processing and properties of refractory metals, joining of ceramic-ceramic and metal-ceramic systems, active braze alloy development, and mechanical modeling of soldered and brazed assemblies. The purpose of this presentation is to highlight his research and engineering accomplishments, particularly during his professional career at Sandia National Laboratories in Albuquerque, NM.

  7. Dr. Wernher von Braun In His Office

    NASA Technical Reports Server (NTRS)

    1964-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paperclip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. This photo depicts von Braun in his office at MSFC.

  8. Centennial Presidential Perspective: Dr. Alfred Blalock

    PubMed Central

    Beaty, Claude A.; George, Timothy J.; Conte, John V.

    2014-01-01

    Great men are not a common occurrence. Indeed, they are a rare find. Though respected and lauded in their time, it is only in retrospect that their true contributions can be adequately measured as a surgeon, an educator and a scientist. Such is the case of Dr. Alfred Blalock. Many have considered him the father of modern cardiac surgery. All consider his “blue baby” operation to be one of the landmarks of cardiac surgery and, as the chief of surgery at Johns Hopkins, he trained many who would become the leaders of our discipline. His continual reach for excellence helped him to not only affect, but revolutionize the paradigm of surgical research, an understanding of the physiology of shock and the surgical management of pulmonic stenosis/atresia. Dr. Blalock was the 30th president of the American Association for Thoracic Surgery and his presidential address was given in 1951. PMID:22248679

  9. Analysis of DR4 haplotypes in insulin dependent diabetes (IDD)

    SciTech Connect

    Monos, D.S.; Radka, S.F.; Zmijewski, C.M.; Kamoun, M.

    1986-03-05

    Population studies indicate that HLA-DR4 is implicated in the susceptibility of IDD. However, biochemical characterization of the serologically defined DR4 haplotype from normal individuals revealed five DR4 and three DQW3 molecular forms. Hence, in this study, they investigated the heterogeneity of the DR4 haplotype, using B-lymphoblastoid cell lines (B-LCL) generated from patients with IDD and seropositive for DR4. Class II molecules, metabolically labeled with /sup 35/S-methionine, were immunoprecipitated with monoclonal antibodies specific for DR(L243), DQ(N297), DQW3(IVD12) or DR and DQ(SG465) and analyzed by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). The isoelectrofocusing (IEF) conditions employed in this study allow representation only of the DR4 haplotype from either DR3/4 or DR4/4 cell lines. The analysis of six different DR4 haplotypes from seven IDD patients, revealed the presence of two DR4 ..beta.. and two DQW3 ..beta.. chains. Three of the six DR4 ..beta.. haplotypes analyzed shared the same DR4 ..beta.. chain and three others shared a different one. Additionally five of the six haplotypes shared a different one. Additionally five of the six haplotypes shared the same DQW3 ..beta.. chain and only one was carrying a different one. Different combinations of the two DR4 and two DQW3 ..beta.. chains constitute three distinct patterns of DR4 haplotypes. These results suggest the prevalence of a DQW3 ..beta.. chain in the small sample of IDD patients studied. Studies of a large number of patients should clarify whether IDD is associated with unique variants of DR4 or DQW3 ..beta.. chains.

  10. On the trail of Dr. Fifer.

    PubMed

    Asche, G

    1996-05-01

    A gift from a patient drew Hope, BC, family physician Gerd Asche irrevocably into the local medical history of the 1858 Fraser River Gold Rush. Because of his interest in Dr. Max William Fifer, Asche undertook research missions in British Columbia, England and the US, converted his computer room to a research and writing centre, and wrote a biography of his predecessor and colleague. He recounts his experience and the growing satisfaction provided by his interest in medical history.

  11. Working with Dr. Per V. Bruel

    NASA Astrophysics Data System (ADS)

    Gade Kjaer, Svend

    2002-11-01

    For more than a decade I have had the pleasure to work as an application specialist together with--and for--Dr. Bruel, one of the founders of the Bruel & Kjaer Company, famous for sound and vibration measurement instrumentation, often nicknamed ''Green Boxes.'' It has been a great experience for me, and I recall this period in my life as one where I was much inspired by Dr. Bruel's methods, both as a private person and with his work as a director for the company and leader of both the sales and the innovation departments. In this presentation I will highlight some funny stories that are told about Dr. Bruel combined with the episodes that I have experienced myself. In short, the most simple way to characterize this rather complex person is maybe by repeating his vision statement for the company: ''We shall have fun and we shall make money. On the other hand we shall not have so much fun that we do not make any money, and we shall not make so much money that we do not have any fun!'' For Per Bruel, acoustics is one of his great hobbies. He has others such as cars, airplanes, motorbikes (he is the lucky owner of a Danish Nimbus) and wine.

  12. Frequency of cancer in children residing in Mexico City and treated in the hospitals of the Instituto Mexicano del Seguro Social (1996–2001)

    PubMed Central

    Juárez-Ocaña, Servando; González-Miranda, Guadalupe; Mejía-Aranguré, Juan Manuel; Rendón-Macías, Mario Enrique; Martínez-García, María del Carmen; Fajardo-Gutiérrez, Arturo

    2004-01-01

    Background The objective of this article is to present the frequency of cancer in Mexican children who were treated in the hospitals of the Instituto Mexicano del Seguro Social in Mexico City (IMSS-MC) in the period 1996–2001. Methods The Registry of Cancer in Children, started in 1996 in the IMSS-MC, is an on-going, prospective register. The data from 1996 through 2001 were analyzed and the different types of cancer were grouped according to the International Classification for Cancer in Children (ICCC). From this analysis, the general and specific frequencies by age and by sex were obtained for the different groups of neoplasms. Also, the frequency of the stage of the disease that had been diagnosed in cases of children with solid tumors was obtained. Results A total of 1,702 new cases of children with cancer were registered, with the male/female ratio at 1.1/1. Leukemias had the highest frequency with 784 cases (46.1%) and, of these, acute lymphoblastic leukemias were the most prevalent with 614 cases (78.3%). Thereafter, in descending order of frequency, were tumors of the central nervous system (CNST) with 197 cases (11.6%), lymphomas with 194 cases (11.4%), germinal cell tumors with 110 cases (6.5%), and bone tumors with 97 cases (5.7%). The highest frequency of cancer was found in the group of one to four year-olds that had 627 cases (36.8%). In all the age groups, leukemias were the most frequent. In the present work, the frequency of Hodgkin's disease (~4%) was found to be lower than that (~10%) in previous studies and the frequency of tumors of the sympathetic nervous system was low (2.3%). Of those cases of solid tumors for which the stage of the disease had been determined, 66.9% were diagnosed as being Stage III or IV. Conclusions The principal cancers in the children treated in the IMSS-MC were leukemias, CNST, and lymphomas, consistent with those reported by developed countries. A 2.5-fold reduction in the frequency of Hodgkin's disease was found

  13. Dr. von Braun at the Manufacturing and Engineering Laboratory

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Dr. von Braun, Director of the Marshall Space Flight Center, listens attentively to a briefing on the metal forming techniques by Dr. Mathias Siebel of the Manufacturing and Engineering Laboratory at MSFC on October 17, 1967.

  14. Dr. Wernher Von Braun examines a ruby crystal.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, and Dr. Eberhard Rees (left), deputy director, technical, examine a ruby crystal used in laser experiments in the Marshall Center's Space Sciences Laboratory.

  15. Dr. von Braun Conferring With NASA Headquarters Officials

    NASA Technical Reports Server (NTRS)

    1961-01-01

    This photograph, dated November 13, 1961, shows Dr. von Braun conferring with two officials from NASA Headquarters. Dr. Brainered Holmes is on the left. Dr. Nicholas Golovin is in the center. Holmes was Director of NASA's Office of Marned Space Flight. Golovin was Director of Systems Engineering at Headquarters.

  16. Interview with Dr Joseph Murray (by Francis L Delmonico).

    PubMed

    Murray, Joseph

    2002-10-01

    The Editors asked Dr Delmonico to interview Dr Joseph Murray, winner of the Nobel prize in Medicine 1990 for performing the first successful renal transplant, to record recollections of the issues of the 1950s, when clinical transplantation was born, on Dr Murray's medical career in transplantation, and on some contemporary issues.

  17. NASA Sponsors Cancer Research at Children's Hospital

    NASA Technical Reports Server (NTRS)

    1998-01-01

    NASA Administrator Dan Goldin (left), during a visit at Children's Hospital of Wisconsin in Milwaukee, Wisconsin, discussed how NASA's special lighting technology may soon treat cancer. Goldin talked with Dr.Harry Whelan (right) and Dr. Kerneth Reichert (center left), both pediatric neurologists with the Hospital and professors at the Medical College of Wisconsin in Milwaukee. Accompanied by Astronaut Mary Ellen Weber, Goldin was shown this innovative treatment, called Photodynamic Therapy, a method used to destroy the tumor without damaging the delicate brain tissue around it. The treatment uses tiny pinhead-size Light Emitting Diodes (LEDs) developed for Space Product Development plant growth experiments.

  18. Multiwavelength observations of two B-star nurseries - DR 15 and DR 20

    SciTech Connect

    Odenwald, S.F.; Campbell, M.F.; Shivanandan, K.; Schwartz, P.; Fazio, G.G.; Moseley, H. Colby College, Waterville, ME Naval Research Laboratory, Washington, DC Harvard-Smithsonian Center for Astrophysics, Cambridge, MA NASA, Goddard Space Flight Center, Greenbelt, MD )

    1990-01-01

    New observations of DR 15 and 20 are reported as part of a study of compact H II regions in the Cyg X region. The radio and FIR data for these objects, when combined with (C-12)O maps, IRAS imagery, and optical photographs, provide new insights into the structure of this complex region and the nature of the star-formation process there. The observations show that DR 15 may consist of one or two B0 ZAMS stars whose H I regions have formed a low-density cavity within a molecular cloud. DR 20 appears to be a young OB cluster. The cluster is dominated by an O5.5 ZAMS star and also contains an approximately 3500-yr-old B0 star appearing as a compact H II region, along with weak FIR sources that may be B0-star candidates. 36 refs.

  19. Festschrift in honour of Dr. Roger Keith

    PubMed Central

    McAlister, Vivian

    2017-01-01

    Summary The festschrift in honour of Dr. Roger Keith, past editor of the Canadian Journal of Surgery, includes essays (available at canjsurg.ca), written from a personal perspective, on the development of specialty surgery in Canada (Richard Nason, Michael Marcaccio, Michael Kelly and Lissa Peeling), evolution of the certification examination (Ward Davies), building of a megahospital (Gerald Fried) and on the changes in surgical education (Edward Davies, Christopher DeGara, E. Christopher Ellison, Richard Prinz and William Pollett), as well as personal reflections (Andrew Warshaw, Stewart Hamilton).

  20. A failure management prototype: DR/Rx

    NASA Technical Reports Server (NTRS)

    Hammen, David G.; Baker, Carolyn G.; Kelly, Christine M.; Marsh, Christopher A.

    1991-01-01

    This failure management prototype performs failure diagnosis and recovery management of hierarchical, distributed systems. The prototype, which evolved from a series of previous prototypes following a spiral model for development, focuses on two functions: (1) the diagnostic reasoner (DR) performs integrated failure diagnosis in distributed systems; and (2) the recovery expert (Rx) develops plans to recover from the failure. Issues related to expert system prototype design and the previous history of this prototype are discussed. The architecture of the current prototype is described in terms of the knowledge representation and functionality of its components.

  1. Dr. Matataro Matsumoto: his career and achievements.

    PubMed

    Okamoto, S

    1976-01-01

    Dr. M. Matsumoto (1865--1943) is the most eminent figure in the history of psychology in Japan. Before the close of the last century, he acquired the scientific methods and technics of experimental psychology in America and Germany and introduced all of them into Japanese universities. Establishing psychological laboratories in both Tokyo and Kyoto, he trained many famous psychologists. He advocated "Psychocynematics" as early as 1910. Together with his followers he applied psychology to every aspect of our daily life. He organized the Japanese Psychological Association and several periodicals were started under his leadership. He also made some important artistic contributions to the fields of picture and caligraphy.

  2. On the trail of Dr. Fifer.

    PubMed Central

    Asche, G

    1996-01-01

    A gift from a patient drew Hope, BC, family physician Gerd Asche irrevocably into the local medical history of the 1858 Fraser River Gold Rush. Because of his interest in Dr. Max William Fifer, Asche undertook research missions in British Columbia, England and the US, converted his computer room to a research and writing centre, and wrote a biography of his predecessor and colleague. He recounts his experience and the growing satisfaction provided by his interest in medical history. Images p1398-a PMID:8616743

  3. Dr. Jan Rogers with Electrostatic Levitator

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Dr. Jan Rogers, project scientist for the Electrostatic Levitator (ESL) at NASA's Marshall Space Flight Center(MSFC). The ESL uses static electricity to suspend an obejct (about 2-3 mm in diameter) inside a vacuum chamber while a laser heats the sample until it melts. This lets scientists record a wide range of physical properties without the sample contacting the container or any instruments, conditions that would alter the readings. The Electrostatic Levitator is one of several tools used in NASA's microgravity materials sciences program.

  4. Mother-baby friendly hospital.

    PubMed

    Aragon-choudhury, P

    1996-01-01

    In Manila, the Philippines, the Dr. Jose Fabella Memorial Hospital has been a maternity hospital for 75 years. It averages 90 deliveries a day. Its fees are P200-P500 for a normal delivery and P800-P2000 for a cesarean section. Patients pay what they can and pay the balance when they can. The hospital provides a safe motherhood package that encompasses teaching responsible parenthood, prenatal care, labor, delivery, postpartum care, breast feeding, family planning, and child survival. In 1986, the hospital introduced innovative policies and procedures that promote, protect, and support breast feeding. It has a rooming-in policy that has saved the hospital P6.5 million so far. In the prenatal stage, hospital staff inform pregnant women that colostrum protects the newborn against infections, that suckling stimulates milk production, and that there is no basis to the claim of having insufficient breast milk. Sales representatives of milk substitutes are banned from the hospital. Staff confiscate milk bottles or formula. A lactation management team demonstrates breast feeding procedures. Mothers also receive support on the correct way of breast feeding from hospital staff, volunteers from the Catholic Women's League, consumer groups, and women lawyers. The hospital's policy is no breast milk, no discharge. This encourages mothers to motivate each other to express milk immediately after birth. The hospital has received numerous awards for its breast feeding promotion efforts. UNICEF has designated Fabella Hospital as a model of the Baby-Friendly Hospital Initiative. The hospital serves as the National Lactation Management Education Training Center. People from other developing countries have received training in lactation management here. The First Lady of the Philippines, the First Lady of the US, and the Queen of Spain have all visited the hospital. The hospital has also integrated its existing services into a women's health care center.

  5. The life and work of Dr. George Byron Hayes, pioneer maxillofacial surgeon.

    PubMed

    Ring, M E

    1999-11-01

    When the First World War broke out in April of 1914, an American dentist practicing in Paris offered his services to the French government. He was Dr. George Byron Hayes, a native of a small upstate New York village and a graduate of the dental school of the University of Michigan. The new type of trench warfare led to facial wounds on a scale never before experienced in any conflict. But the military medical services had no experience or skill in dealing with these new and devastating wounds. Dr. Hayes stepped into the breach and performed such exceptional and often miraculous surgery that he was hailed by the entire Western world. The French government made him a Chevalier of the Legion of Honor and the U.S. government awarded him the Distinguished Service Medal, seldom awarded to a civilian. The most prominent surgeon of the day, Dr. Harvey Cushing, brought a team of physicians from Harvard to observe the treatment rendered wounded soldiers in the American Hospital in Neuilly, France, and, in lauding Dr. Hayes' work, stated that his contributions were the most remarkable of all, and that dental surgery should now be recognized as a specialty, the equal of any in medicine.

  6. White dwarfs identified in LAMOST DR 2

    NASA Astrophysics Data System (ADS)

    Guo, Jincheng; Zhao, Jingkun; Tziamtzis, Anestis; Liu, Jifeng; Li, Lifang; Zhang, Yong; Hou, Yonghui; Wang, Yuefei

    2015-12-01

    Here we present a catalogue of 1056 spectroscopically identified hydrogen-dominated white dwarfs (DAWDs), 34 helium-dominated white dwarfs (DBWDs) and 276 white dwarf main sequence (WDMS) binaries from the Large sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) survey data release 2 (DR2). 383 DAWDs, 4 DBWDs and 138 WDMSs are new identifications after cross-match with literature. There are ˜4100 k spectra in total from DR 2. The low ratio of white dwarfs found in LAMOST is attributed to biased selection of LAMOST input catalogue and much brighter targets relative to stars observed in Sloan Digital Sky Survey. In this paper, a new DAWD selection method is adopted as a new attempt and supplement to the traditional methods. The effective temperature, surface gravity, mass, cooling age and distance of high signal-to-noise DAWDs are estimated. The peak of the mass distribution is found to be ˜0.6 M⊙, which is consistent with previous work. The parameters of WDMS binaries are also provided in this paper. As the foundation of our future work, which is to identify more WDs with debris disc, WDs found in LAMOST showed a lot of potential. Interesting infrared-excess WDs will be reported in our forthcoming paper.

  7. [Maternal mortality rate in the Aurelio Valdivieso General Hospital: a ten years follow up].

    PubMed

    Noguera-Sánchez, Marcelo Fidias; Arenas-Gómez, Susana; Rabadán-Martínez, Cesar Esli; Antonio-Sánchez, Pedro

    2013-01-01

    Antecedentes: en México, la mortalidad materna ha disminuido en las últimas décadas. En Oaxaca esto no se ha manifestado porque se incrementó la tasa de mortalidad materna. Este estado se ubica entre las entidades con más muertes maternas. Objetivo: analizar 10 años de mortalidad materna en el Hospital General Dr. Aurelio Valdivieso de los Servicios de Salud de Oaxaca, para conocer el comportamiento epidemiológico y caracterización de los decesos. Material y métodos: estudio retrospectivo, transversal y descriptivo efectuado mediante la revisión de expedientes clínicos de mortalidad materna en la División de Gineco-Obstetricia. Se consideraron variables sociales, obstétricas y circunstanciales y las comprobaciones se efectuaron con estadística general y descriptiva. Resultados: entre el 1 de enero de 2000 y el 31 de diciembre de 2009 se registraron 109 muertes maternas, excluidas dos que no fueron obstétricas; es decir, que hubo 107 muertes maternas: 75 directas y 32 indirectas. La tasa de mortalidad materna fue de 172.14 × 100,000 nacidos vivos. De las muertes maternas revisadas 89 pudieron evitarse (83%) y 18 no (17%), esto con base en el dictamen del Comité ad hoc del Hospital General Dr. Aurelio Valdivieso. La enfermedad hipertensiva aguda del embarazo fue la de mayor mortalidad; la escolaridad y el puerperio ueron el mayor riesgo. Conclusiones: las variables atribuibles a bajo índice de desarrollo humano, como: baja escolaridad y paridad elevada incrementaron el riesgo de mortalidad materna, que fue intrahospitalaria y durante el puerperio. La tasa de mortalidad materna fue la mayor encontrada en publicaciones nacionales con respecto a este referente.

  8. Dual agonist Surrobody™ simultaneously activates death receptors DR4 and DR5 to induce cancer cell death

    PubMed Central

    Milutinovic, Snezana; Kashyap, Arun K.; Yanagi, Teruki; Wimer, Carina; Zhou, Sihong; O' Neil, Ryann; Kurtzman, Aaron L.; Faynboym, Alexsandr; Xu, Li; Hannum, Charles H.; Diaz, Paul W.; Matsuzawa, Shu-ichi; Horowitz, Michael; Horowitz, Lawrence; Bhatt, Ramesh R.; Reed, John C.

    2015-01-01

    Death receptors of the Tumor Necrosis Factor (TNF) family are found on surface of most cancer cells and their activation typically kills cancer cells through the stimulation of the extrinsic apoptotic pathway. The endogenous ligand for death receptors-4 and -5 (DR4 and DR5) is Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand, TRAIL (Apo2L). Since most untransformed cells are not susceptible to TRAIL-induced apoptosis, death receptor activators have emerged as promising cancer therapeutic agents. One strategy to stimulate death receptors in cancer patients is to use soluble human recombinant TRAIL protein, but this agent has limitations of a short half-life and decoy receptor sequestration. Another strategy that attempted to evade decoy receptor sequestration and to provide improved pharmacokinetic properties was to generate DR4 or DR5 agonist antibodies. The resulting monoclonal agonist antibodies overcame the limitations of short half-life and avoided decoy receptor sequestration, but are limited by activating only one of the two death receptors. Here, we describe a DR4 and DR5 dual agonist produced using Surrobody™ technology that activates both DR4 and DR5 to induce apoptotic death of cancer cells in vitro and in vivo and also avoids decoy receptor sequestration. This fully human anti-DR4/DR5 Surrobody displays superior potency to DR4- and DR5-specific antibodies, even when combined with TRAIL-sensitizing pro-apoptotic agents. Moreover, cancer cells were less likely to acquire resistance to Surrobody than either anti-DR4 or anti-DR5 mono-specific antibodies. Taken together, Surrobody shows promising preclinical pro-apoptotic activity against cancer cells, meriting further exploration of its potential as a novel cancer therapeutic agent. PMID:26516157

  9. Enrico Fermi Awards Ceremony for Dr. Mildred S. Dresselhaus and Dr. Burton Richter, May 2012 (Presentations, including remarks by Energy Secretary, Dr. Steven Chu)

    SciTech Connect

    Chu, Steven

    2012-05-07

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On May 7, 2012 it was conferred upon two exceptional scientists: Dr. Mildred Dresselhaus, 'for her scientific leadership, her major contributions to science and energy policy, her selfless work in science education and the advancement of diversity in the scientific workplace, and her highly original and impactful research,' and Dr. Burton Richter, 'for the breadth of his influence in the multiple disciplines of accelerator physics and particle physics, his profound scientific discoveries, his visionary leadership as SLAC Director, his leadership of science, and his notable contributions in energy and public policy.' Dr. John Holder, Director of the White House Office of Science and Technology Policy, opened the ceremony, and Dr. Bill Brinkman, Director of DOE's Office of Science introduced the main speaker, Dr. Steven Chu, U.S. Energy Secretary.

  10. Enrico Fermi Awards Ceremony for Dr. Mildred S. Dresselhaus and Dr. Burton Richter, May 2012 (Presentations, including remarks by Energy Secretary, Dr. Steven Chu)

    ScienceCinema

    Chu, Steven (U.S. Energy Secretary)

    2016-07-12

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On May 7, 2012 it was conferred upon two exceptional scientists: Dr. Mildred Dresselhaus, 'for her scientific leadership, her major contributions to science and energy policy, her selfless work in science education and the advancement of diversity in the scientific workplace, and her highly original and impactful research,' and Dr. Burton Richter, 'for the breadth of his influence in the multiple disciplines of accelerator physics and particle physics, his profound scientific discoveries, his visionary leadership as SLAC Director, his leadership of science, and his notable contributions in energy and public policy.' Dr. John Holder, Director of the White House Office of Science and Technology Policy, opened the ceremony, and Dr. Bill Brinkman, Director of DOE's Office of Science introduced the main speaker, Dr. Steven Chu, U.S. Energy Secretary.

  11. Norovirus - hospital

    MedlinePlus

    Gastroenteritis - norovirus; Colitis - norovirus; Hospital acquired infection - norovirus ... fluids ( dehydration ). Anyone can become infected with norovirus. Hospital patients who are very old, very young, or ...

  12. [Questions on the first operation with ethyl ether as anaesthetic by Dr. Peter Parker].

    PubMed

    Chen, Q

    2017-01-28

    Ethyl ether was the first accepted effective general anaesthetic. It was introduced into China by an America missionary, Dr. Peter Parker. This was one of the historical events of medical communication between China and the West. In the records of the first operation with ether, however, Dr. Parker unusually omitted the patient's medical record number and the date of the operation, while those of other operations with ether anesthetics were all available. This was very unusual for a doctor like Peter Parker who always recorded every important case in detail in the hospital reports. It seems that he deliberately rather than carelessly omitted the information for some reasons. Based on the analysis of Parker's reports, a conclusion is made that the anesthetic effect of the case was actually ineffective. Furthermore, possible answers to this are outlined and question by discussion based on the situation that Parker faced in the late Qing era.

  13. [Dr. Hideyo Noguchi and Hajime Hoshi].

    PubMed

    Misawa, M

    1991-01-01

    Hajime Hoshi is a founder of Hoshi Pharmaceutical Company and of Hoshi University. He became acquainted with Dr. Hideyo Noguchi in the United States in 1901 during his study abroad. Hoshi often stayed overnight at Noguchi's apartment in Philadelphia. Hoshi and Noguchi were both from Fukushima, Japan, and Hoshi was three years older than Noguchi. Both persons had been good friends until Hoguchi died in 1928. Hoshi and Noguchi together had met Hirobumo Ito and Thomas Edison. In 1906, Hoshi came back to Japan after a 12-year stay in the United States. The financial support by Hoshi enabled the only and one temporary returning of Noguchi to Japan in 1915. In this paper, the friendship between the famous two persons is described in detail.

  14. Dr. Cheryl Nickerson studies Salmonella Typhimurium

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Cheryl Nickerson of Tulane University is studying the effects of simulated low-g on a well-known pathogen, Salmonella typhimurium, a bacterium that causes two to four million cases of gastrointestinal illness in the United States each year. While most healthy people recover readily, S. typhimurium can kill people with weakened immune systems. Thus, a simple case of food poisoning could disrupt a space mission. Using the NASA rotating-wall bioreactor, Nickerson cultured S. typhimurium in modeled microgravity. Mice infected with the bacterium died an average of three days faster than the control mice, indicating that S. typhimurium's virulence was enhanced by the bioreactor. Earlier research showed that 3 percent of the genes were altered by exposure to the bioreactor. Nickerson's work earned her a 2001 Presidential Early Career Award for Scientists and Engineers.

  15. The Hospital for the Ruptured and Crippled Renamed The Hospital for Special Surgery 1940; The War Years 1941–1945

    PubMed Central

    2008-01-01

    In 1939, the 75th anniversary program marking the founding of the Hospital for the Ruptured and Crippled (R & C), the oldest orthopaedic hospital in the nation, was held at the hospital site in New York City. Dr. Philip D. Wilson, Surgeon-in-Chief since 1935, used this event to mark the return of the hospital to its leadership role in the country. When the Hospital for the Ruptured and Crippled first opened its doors on May 1, 1863, the name of the hospital was not unusual; it described the type of patients treated. In 1940, the Board of Managers with guidance from Dr. Wilson changed the name to the Hospital for Special Surgery (HSS). In 1941, with Britain engaged in a European war, Dr. Wilson felt there was a need for the Americans to support the British. He personally organized the American Hospital in Britain, a privately funded voluntary unit, to help care for the wounded. After the United States actually entered World War II in December 1941, HSS quickly organized support at all levels with a significant number of professional and auxiliary staff, eventually enlisting in the military. Even with such staff turnover, the hospital continued to function under Dr. Wilson’s leadership. After the war ended in 1945, Wilson forged ahead to further restore HSS as a leader in musculoskeletal medicine and surgery. PMID:19048348

  16. Entrevue avec le Dr Charley Zeanah

    PubMed Central

    2013-01-01

    Le Dr Charles Zeanah est titulaire de la chaire de psychiatrie Mary K. Sellars-Polchow, professeur de pédiatrie clinique et vice-président de la pédopsychiatrie au département de psychiatrie et des sciences du comportement de la faculté de médecine de l’Université Tulane, à la Nouvelle-Orléans. Il est également directeur général de l’institut de la santé mentale des nourrissons et des jeunes enfants de Tulane. Il est récipiendaire de nombreux prix, notamment le prix de prévention Irving Phillips (AACAP), la mention élogieuse présidentielle pour sa recherche et son leadership exceptionnels en santé mentale des nourrissons (American Orthopsychiatric Association), le prix d’excellence clinique Sarah Haley Memorial (International Society for Traumatic Stress Studies), le prix de recherche en pédopsychiatrie Blanche F. Ittelson (APA), et le prix Serge Lebovici Award soulignant les contributions internationales à la santé mentale des nourrissons (World Association for Infant Mental Health). Le Dr Zeanah est fellow distingué de l’AACAP, fellow distingué de l’APA et membre du conseil d’administration de Zero to Three. Il est l’éditeur scientifique de Handbook of Infant Mental Health (3e édition) qui est considéré comme étant le manuel de pointe et la référence de base du domaine de la santé mentale des nourrissons.

  17. The life-work of Prof. MUDr. Zdenek Lojda, Dr.Sc., Dr. Med. et Iur. h.c.

    PubMed

    Hach, P

    2008-01-01

    Professor Zdenek Lojda, MD., Dr.Sc., Dr. Med.h.c., Dr. Jur. h.c., vice-rector emeritus of the Charles University and director emeritus of the Institute of Histology and Embryology of the 1st Medical Faculty of the Charles University in Prague died on the 24th April 2004. Born in Trebíc (in a local maternal hospital on the 7th December 1927) he grew up in Moravské Budejovice where he graduated from a primary and secondary school (he passed out each class as well as the leaving exam at the local gymnasium in 1946 cum laude). He was growing up in an inspiring atmosphere of a family of a professor at gymnasium that helped him to form his fundamental moral attitude and to gain high knowledge of an almost Renaissance comprehension. He was a gifted linguist (he spoke fluently several languages including Latin) and musician (he did community singing among others) and he was interested in natural sciences. In 1946 he enrolled for the medical faculty and coincidentally he was grouped among students that completed histology and embryology at the Institute of Embryology headed by professor Zdenek Frankenberger, MD., who had recognised his interest in this field of study. The young student gave himself and his free time to the work of an unqualified lab-worker and only later he became assistant conducting practical tutorials. He took his degree cum laude in 1952 and he received certificate of competence because of his excellent results. He showed his preoccupation with histology (strongly influenced by the personality of professor Frankenberger) after the graduation when he entered the job of the assistant professor at the Institute of Embryology and he stayed there until 1961. When he was about to decide which problems he should target, professor Frankenberger drew his attention to a very interesting part of histology that was just in advance and that was the use of diazonic salts for formation of colour reaction product demonstrating enzyme activity in tissues. In 1962

  18. Comparative binding to DR4 and DR5 receptors of TRAIL and BNNTs/PAHE/mPEG-DSPE/TRAIL nanoparticles.

    PubMed

    Guillaume, Yves Claude; André, Claire

    2017-01-25

    TRAIL is a member of the tumor necrosis factor family of cytokines, which induces apoptosis of cancer cells, thanks to its binding to its cognate receptors DR5 and DR4. We have recently demonstrated that nanovectorization of TRAIL with single-walled carbon nanotubes enhanced TRAIL affinity to DR5. In this paper, 1-pyrenebutyric acid N-hydroxysuccinimide ester functionalized boron nitride nanotubes (BNNTs) were used to anchor the TRAIL protein. The resulting BNNT/1-pyrenebutyric acid N-hydroxysuccinimide ester nanotubes were mixed with methoxy-poly(ethylene glycol)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-conjugates so as to allow a good dispersion of these nanoparticle TRAIL (NPT) in aqueous solution. The difference of binding between NPT and soluble TRAIL to DR4 and DR5 receptors was then studied by the use of affinity chromatography. DR4 and DR5 receptors were thus immobilized on a chromatographic support, and the binding of the 2 ligands TRAIL and NPT to DR4 and DR5 was studied in the temperature range 30°C to 50°C. Negative enthalpy (ΔH) values indicated that van der Waals interactions and hydrogen bonding are engaged favorably at the ligand-receptor interface. It was shown that their rank-ordered affinities were strongly different in the sequence TRAILDR4  < NPTDR4  < TRAILDR5  < NPTDR5 , and the highest affinity for NPT to DR4 and DR5 receptors observed at low pHs was due to the less accessibility of the His molecular switch to be protonated when TRAIL was immobilized on BNNTs. Taken together, our results demonstrated that nanovectorization of TRAIL with BNNTs enhanced its binding to both DR4 and DR5 receptors at 37°C. Our novel nanovector could potentially be used for delivering TRAIL to cells for cancer treatment.

  19. Dr. Goddard and a 1918 version of 'Bazooka'

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Dr. Robert H. Goddard loading a 1918 version of the Bazooka of World War II. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  20. Rheumatic fever in Ireland: the role of Dr Monica Lea Wilson (1889-1971).

    PubMed

    Ward, O Conor

    2013-02-01

    In 1869 William Stokes pointed out that the severity of rheumatic fever in Dublin had declined over recent decades. Similar worldwide decline led to the closure of many internationally famous rheumatic fever centres. The discovery by Robert Collis that rheumatic fever was a sequel to haemolytic streptococcal infection and the subsequent discovery of penicillin accelerated the decline. St Gabriel's Hospital in Dublin opened in 1951 under the clinical direction of Dr Monica Lea Wilson. Contrary to contemporary medical opinion a regimen of very prolonged bed rest was enforced. From 1961 the family doctors became concerned at the adverse psychological effects of the unnecessarily prolonged hospital stay. Twenty-seven of the 56 inpatients were re-assessed. None of them showed any evidence of active rheumatic fever and their parents took them home. The hospital closed in 1968. Dr Lea Wilson distanced herself from mainstream medicine and she is best remembered for having presented an unrecognized Caravaggio painting to the Jesuit Order in recognition of their pastoral support at the time of the controversial assassination in 1920 of her husband Percival, an Inspector in the Royal Irish Constabulary.

  1. Proc, Dr. Sam, Uncle Henry, and the "Little Green Book". Interview by Charles F. Wooley.

    PubMed

    Harvey, W Proctor

    2005-01-01

    During his house staff training before World War II, Dr. W. Proctor Harvey encountered Dr. Samuel A. Levine at the Peter Bent Brigham Hospital in Boston. Following military service, Harvey returned to Boston and became Levine's first cardiology fellow. The book Clinical Auscultation of the Heart--the Little Green Book by Levine and Harvey in 1949 combined Levine's clinical wisdom with Harvey's objective phonocardiographic methods and brought an important objective dimension to the art of cardiac auscultation. Both Levine and Harvey shared experiences and friendship with Henry Christian, the first Physician-in-Chief when the new Brigham Hospital Opened in 1913. Christian, appointed Dean of the Harvard Medical School in 1908 at the age of 32, was referred to as the "Boy Dean." He held the Hersey Chair of Theory and Practice of Physic from 1908 until 1939, was one of the founding group of the American Society for Clinical Investigation, and a major force in academic medicine. Levine served as intern to Christian and then joined the Brigham medical staff in 1915. Proctor Harvey followed Henry Christian's path from their mutual hometown of Lyunchburg, VA to the Peter Bent Brigham Hospital. A series of illuminating and respectful professional interactions--initially between Christian and Levine, between Levine and Harvey in the early 1940s, and between Harvey and Christian in the 1950s--provide the background for the genesis of the Little Green Book and a remarkable example of academic heritage.

  2. Enrico Fermi Awards Ceremony for Dr. Allen J. Bard and Dr. Andrew Sessler, February 2014 (Presentations, including remarks by Energy Secretary, Dr. Ernest Moniz)

    SciTech Connect

    Moniz, Ernest

    2014-02-03

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On February 3, 2014 it was conferred upon two exceptional scientists. The first to be recognized is Dr. Allen J. Bard, 'for international leadership in electrochemical science and technology, for advances in photoelectrochemistry and photocatalytic materials, processes, and devices, and for discovery and development of electrochemical methods including electrogenerated chemiluminescence and scanning electrochemical microscopy.' The other honoree is Dr. Andrew Sessler, 'for advancing accelerators as powerful tools of scientific discovery, for visionary direction of the research enterprise focused on challenges in energy and the environment, and for championing outreach and freedom of scientific inquiry worldwide.' Dr. Patricia Dehmer opened the ceremony, and Dr. Ernest Moniz presented the awards.

  3. Enrico Fermi Awards Ceremony for Dr. Allen J. Bard and Dr. Andrew Sessler, February 2014 (Presentations, including remarks by Energy Secretary, Dr. Ernest Moniz)

    ScienceCinema

    Moniz, Ernest [U.S. Energy Secretary

    2016-07-12

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On February 3, 2014 it was conferred upon two exceptional scientists. The first to be recognized is Dr. Allen J. Bard, 'for international leadership in electrochemical science and technology, for advances in photoelectrochemistry and photocatalytic materials, processes, and devices, and for discovery and development of electrochemical methods including electrogenerated chemiluminescence and scanning electrochemical microscopy.' The other honoree is Dr. Andrew Sessler, 'for advancing accelerators as powerful tools of scientific discovery, for visionary direction of the research enterprise focused on challenges in energy and the environment, and for championing outreach and freedom of scientific inquiry worldwide.' Dr. Patricia Dehmer opened the ceremony, and Dr. Ernest Moniz presented the awards.

  4. [Septic abortion in the Hospital de Ginecología y Obstetricia no. 3 del Instituto Mexicana de Seguridad Social. Late and early morbidity].

    PubMed

    López Ortiz, E; Sandoval Sevilla, S; Arteaga, V M; Rosas Arceo, J; Ortíz Arroyo, R

    1974-02-01

    268 cases of septic abortion which occurred between 1964-72 in a large metropolitan hospital in Mexico were analyzed retrospecively. There cases represented 0.88% of all cases of abortion during the same time. Most patients were between 21-30, and 48% with parity 2-5; 63% were at their first abortion; only 16 patients declared to have attempted abortion, and most cases were first trimester abortion. Pre- and postoperative procedures and vital signs were carefully taken, and time elapsed from medical treatment to surgery was 4-12 hours. There were 237 curettages, and 28 hysterectomies. Complication from surgery were 4.1%; there were 19 deaths, i.e. 7.5% of patients, of which 10 only 24 hours after hospitalization. Protocol of treatment of septic abortion is discussed, and surgical treatment highly recommended.

  5. SDSS DR7 WHITE DWARF CATALOG

    SciTech Connect

    Kleinman, S. J.; Nitta, A.; Kepler, S. O.; Pelisoli, Ingrid; Pecanha, Viviane; Costa, J. E. S.; Koester, D.; Krzesinski, J.; Dufour, P.; Lachapelle, F.-R.; Bergeron, P.; Yip, Ching-Wa; Harris, Hugh C.; Eisenstein, Daniel J.; Althaus, L.; Corsico, A.

    2013-01-15

    We present a new catalog of spectroscopically confirmed white dwarf stars from the Sloan Digital Sky Survey (SDSS) Data Release 7 spectroscopic catalog. We find 20,407 white dwarf spectra, representing 19,712 stars, and provide atmospheric model fits to 14,120 DA and 1011 DB white dwarf spectra from 12,843 and 923 stars, respectively. These numbers represent more than a factor of two increase in the total number of white dwarf stars from the previous SDSS white dwarf catalogs based on DR4 data. Our distribution of subtypes varies from previous catalogs due to our more conservative, manual classifications of each star in our catalog, supplementing our automatic fits. In particular, we find a large number of magnetic white dwarf stars whose small Zeeman splittings mimic increased Stark broadening that would otherwise result in an overestimated log g if fit as a non-magnetic white dwarf. We calculate mean DA and DB masses for our clean, non-magnetic sample and find the DB mean mass is statistically larger than that for the DAs.

  6. Portrait of Dr Michael G. Hanna, Jr

    PubMed Central

    Hanna Jr, Michael

    2014-01-01

    While a PhD candidate, doing my thesis at the Oak Ridge National Laboratory, Biology Division under Dr. Charles Congdon, my introduction to the immune response was studying graft vs. host (GVH) disease as a consequence of bone marrow transplantation in mice. The sequalae of GVH was impressive, and demonstrated the potential of negative clinical consequences of the immune system. The idea of harnessing this immunological phenomena in cancer therapy was appealing even in the late 1960s. The problem was that at the time T-cells as a component of the immune system were identified but not defined. We moved to soluble antigen stimulation in mice and recognized and described the post antigen stimulation changes in lymphatic tissue germinal centers during the first 48 h after the induction of the humoral immune response. We described the extracellular localization of soluble antigens on the surface of dendritic reticular cells of the stroma, directing a response of B-cells to produce antibody against non-self. The ensuing reaction was the rapid proliferation of B-cells toward antibody secreting plasma cells. PMID:25424782

  7. Dr. Rudolph Binion: professor, mentor, psychohistorian.

    PubMed

    Szaluta, Jacques

    2015-01-01

    As the title of my paper indicates, Dr. Rudolph Binion was my professor, mentor, and a leading psychohistorian. My paper in memoriam to Rudolph Binion is intended as both a retrospective and an introspective account of my relationship with him, as he had a pivotal influence on me when he was my professor at Columbia University. His help and influence continued after I left graduate school. In my paper I also deal with the enormous stresses of navigating through graduate school, for those students whose goal was to earn the Ph.D. degree. Some examinations were dreaded, For Example The "Examination in Subjects," popularly called the "Oral Exam." The "incubation" period was long indeed, frequently averaging nearly ten years, and it was an ordeal, as the rate of attrition was very high. There is then also the question of "ego strength" and that of "transference" toward the professor. Graduate school is indeed a long and strenuous challenge. I took a seminar in modern French history, a requirement for the Master's degree with Professor Binion, which was consequential for me, as he taught me to be objective in writing history. Professor Binion was a demanding and outstanding teacher.

  8. DR with a DSLR: Digital Radiography with a Digital Single-Lens Reflex camera.

    PubMed

    Fan, Helen; Durko, Heather L; Moore, Stephen K; Moore, Jared; Miller, Brian W; Furenlid, Lars R; Pradhan, Sunil; Barrett, Harrison H

    2010-02-15

    An inexpensive, portable digital radiography (DR) detector system for use in remote regions has been built and evaluated. The system utilizes a large-format digital single-lens reflex (DSLR) camera to capture the image from a standard fluorescent screen. The large sensor area allows relatively small demagnification factors and hence minimizes the light loss. The system has been used for initial phantom tests in urban hospitals and Himalayan clinics in Nepal, and it has been evaluated in the laboratory at the University of Arizona by additional phantom studies. Typical phantom images are presented in this paper, and a simplified discussion of the detective quantum efficiency of the detector is given.

  9. Celebrating the Life and Legacy of Dr. John Hope Franklin

    ERIC Educational Resources Information Center

    Harris, Robert L., Jr.; Levering-Lewis, David; French, John D.; Wharton, Clifton R., Jr.

    2009-01-01

    Dr. John Hope Franklin chronicled the experiences of African-Americans like no one before him, forcing America to recognize Black history as American history. His contributions were innumerable and his impact was abiding. In celebration of his life and legacy, the authors profile the celebrated scholar and activist, Dr. John Hope Franklin.

  10. Dr. Albert Carr--Science Educator 1930-2000

    ERIC Educational Resources Information Center

    Lopez, Leslie

    2013-01-01

    The very first issue of "Educational Perspectives" was published in October of 1962. Dr. Albert Carr wrote one of the inaugural essays on the topic of current developments in science education, and he went on to write several other articles for the journal. This article shares why Dr. Albert Carr's colleagues remember him for his…

  11. Dr. Irene Sänger-Bredt, a life for astronautics

    NASA Astrophysics Data System (ADS)

    Zaganescu, Nicolae-Florin

    2004-12-01

    Irene Bredt (b.1911 at Bonn) obtained her Doctorate in Physics in 1937; in the same year she became a scientific researcher at the German Research Center for Aviation at Trauen, led by Prof. Dr. Eugen Sänger. Soon, the young but efficient Dr. Irene Bredt became the first assistant of Dr. Sänger, who married her (1951). During 1973-1978, Dr. Bredt was in correspondence with Prof. Dr. Nikolae-Florin Zaganescu and helped him to familiarize the Romanian readers with Prof. Sänger's life and achievements. As for Dr. Bredt's life, she specified three main periods of her activity: 1937-1942, when she was researcher in charge of thermodynamic problems of liquid-fuelled rocket engines at Trauen 1942-1945, when she was Senior Researcher in charge of Ramjet in flight performances at Ainring, and also coauthored the Top Secret Technical report entitled 'A Rocket Engine for a Long-Range Bomber', which was finished in 1941 but edited only in 1944 the post world war II period, when she was Scientific Advisor or Director at various civil and military research institutes, universities, etc. Dr. Irene Sänger-Bredt helped her husband to develop many scientific theories like Ramjet thermodynamic theory, and photon rocket theory and also in establishing IAF and IAA. In 1970, Dr. Irene Sänger-Bredt was honored with 'Hermann Oberth Gold Medal' for her impressive scientific activity.

  12. Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis

    NASA Technical Reports Server (NTRS)

    Lewis, Cathleen; Wright, Rebecca

    2012-01-01

    Dr. Cathleen Lewis was interviewed by Rebecca Wright during the presentation of an "Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis" on May 14, 2012. Topics included the care, size, and history of the spacesuit collection at the Smithsonian and the recent move to the state-of-the-art permanent storage facility at the Udvar-Hazy facility in Virginia.

  13. Dr. Wernher Von Braun near the mobile launcher.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. George Mueller, NASA associate administrator for manned space flight, and Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, are seen near the mobile launcher carrying a 363 foot tall Saturn V space launch vehicle as the rocket is rolled from the vehicle assembly building at KSC for its three mile trip to the launch pad.

  14. Biotechnology Symposium - In Memoriam, the Late Dr. Allan Zipf

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A one-day biotechnology symposium was held at Alabama A&M University (AAMU), Normal, AL on June 4, 2004 in memory of the late Dr. Allan Zipf (Sept 1953-Jan 2004). Dr. Zipf was a Research Associate Professor at the Department of Plant and Soil Sciences, AAMU, who collaborated extensively with ARS/MS...

  15. Dr. Shawn Mehlenbacher 2012 Wilder Silver Medal Recipient

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dr. Shawn Mehlenbacher, Oregon State University, was awarded the 2012 Wilder Medal by the American Pomological Society for his contributions to hazelnut genetics and cultivar development. Dr. Mehlenbacher took over the leadership of the Oregon State University hazelnut breeding program in 1986 aft...

  16. Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Marshall Space Flight Center (MSFC) Director, Dr. von Braun, submerges after spending some time under water in the MSFC Neutral Buoyancy Simulator (NBS). Weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

  17. Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Astronaut L. Gordon Cooper checks the neck ring of a space suit worn by Marshall Space Flight Center (MSFC) Director, Dr. von Braun before he submerges into the water of the MSFC Neutral Buoyancy Simulator (NBS). Wearing a pressurized suit and weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

  18. Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Marshall Space Flight Center (MSFC) Director, Dr. von Braun, is shown leaving the suiting-up van wearing a pressure suit prepared for a tryout in the MSFC Neutral Buoyancy Simulator (NBS). Weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

  19. The 1850 Webster/Parkman Trial: Dr. Keep's forensic evidence.

    PubMed

    Christen, Arden G; Christen, Joan A

    2003-03-01

    Shortly before two o'clock on a chilly November afternoon in 1849, the celebrated Harvard physician and surgeon, Dr. George Parkman, left his home on Boston's fashionable Beacon Hill, expecting to return in a few hours. He was never seen alive again. This account describes Parkman's brutal murder and explores the dynamics which preceded this crime. It explains how and why Dr. John White Webster, MD, Professor of Chemistry and Mineralogy at Harvard University, killed Dr. Parkman and unsuccessfully attempted to destroy the physical evidence. Webster's subsequent trial, conviction and ultimate punishment are also detailed. The Parkman-Webster case remains one of the classic murders in the annals of American crime. Compelling dental evidence presented by the famous American dentist, Dr. Nathan Cooley Keep, directly led to the conviction of Dr. Webster. This graphic, ground-breaking case clearly established the viable role of forensic dentistry in legal criminal investigation.

  20. 105-DR Large Sodium Fire Facility closure activities evaluation report

    SciTech Connect

    Adler, J.G.

    1996-04-11

    This report evaluates the closure activities at the 105-DR Large Sodium Fire Facility. The evaluation compares these activities to the regulatory requirements and closure plan requirements. The report concludes that the areas identified in the closure plan can be clean closed. This report summarizes and evaluates the closure activities performed in support of partial closure of the 105-DR Large Sodium Fire Facility (LSFF). This evaluation will be used in assessing the condition of the 105-DR LSFF for the purpose of meeting the partial clean closure conditions described in the 105-DR Large Sodium Fire Facility Closure Plan (DOE-RL 1995). Based on the evaluation of the decontamination activities, sampling activities, and sample data, it is has been determined that the partial clean closure conditions for the 105-DR LSFF have been met.

  1. [Hospitals and surgeons: Madrid 1940].

    PubMed

    de Quevedo, Francisco Vázquez

    2007-01-01

    The history of the hospitals and general surgeons that best represent the centres in Madrid are here in reviewed, comprising the period between 1940 and the closure of the Hospital Clinico (1957) as well as the Hospital General (General Hospital) (1967), both in Atocha. Other hospitals which are reviewed and highlighted are: the H. de la Princesa (the Princess Hospital), the H. del Nifio Jesus (Hospital of the Child Jesus), the H. Militar (Military Hospital) and the Cruz Roja (Red Cross). Data is provided on the permanent surgeons in the following centres: H. General: J. Goyanes, J. Die, J. de la Villa, T. Rodriguez, E. Diaz, G. Bueno e H. Huerta; H. Clinico: L. de la Peña, L. Cardenal, L. Olivares, R. Argüelles, J. Estella y M. F. Zumel; H. Militar: M. G. Ulla, M. Bastos, M. G. Durán, J. S. Galindo, y A. G. Durán; Hospital de la Cruz Roja: V. M. Noguera, L. Serrada, F. Luque y L. L. Durán; H. de la Princesa: P. Cifuentes, P. G. Duarte, L. Estella y R. Aiguabella; H. del Niño Jesús: J. Garrido Lestache; H. Clinico, last time, Atocha: F. M. Lagos, R. Vara y A. de la Fuente.

  2. The impact of DR3 microvariation on peptide binding: the combinations of specific DR beta residues critical to binding differ for different peptides.

    PubMed

    Posch, P E; Hurley, C K; Geluk, A; Ottenhoff, T H

    1996-09-01

    HLA-DR molecules are a group of highly polymorphic glycoprotein heterodimers that present peptide antigens to T lymphocytes for immune surveillance. To assess the significance of limited polymorphism on the functional differentiation of DR molecules, the binding of several immunogenic peptides to the DR3 microvariants [DR(alpha, beta 1*0302) and DR(alpha, beta 1*0301)] and to mutants of these DR3 molecules was examined. This analysis has shown that each residue (DR beta 26, DR beta 28, DR beta 47, and DR beta 86), which differentiates these two DR3 molecules, contributes to their functional distinction and that the relative contribution of each residue varies for different peptide/DR3 complexes. For example, DR beta 28 and DR beta 86 controlled the mycobacterium tuberculosis 65-kD heat shock protein peptides 3-13 and 4-15 (HSP) binding specificity to DR (alpha, beta 1*0301). [HSP does not bind to DR(alpha, beta 1*0302)], whereas DR beta 26, DR beta 28, and DR beta 86 controlled the influenza hemagglutinin peptide 306-318 (HA) binding specificity to DR(alpha, beta 1*0302). [HA does not bind to DR(alpha, beta 1*0301).] In comparison, DR beta 86 alone controlled the binding level difference of sperm whale myoglobin peptide 132-151 (SWM) and of myelin basic protein peptide 152-170 (MBP) [both bind to DR(alpha, beta 1*0301) at levels five times greater than to DR(alpha, beta 1*0302)] to the DR3 molecules. Although not critical, additional DR beta residues influenced the binding level of individual peptides of each of the DR3 molecules and, again, the combinations of these residues differed for different peptide/DR3 complexes. These data showed that individual DR residues vary in their relative contribution to the interaction between a specific DR molecule and different peptides and that limited polymorphism can create substantial differences in the peptide binding profiles among DR molecules.

  3. Study of HLA-DR synthesis in cultured human keratinocytes.

    PubMed

    Wikner, N E; Huff, J C; Norris, D A; Boyce, S T; Cary, M; Kissinger, M; Weston, W L

    1986-11-01

    Within the normal human epidermis only Langerhans and indeterminate cells express HLA-DR. Human keratinocytes (HK), however, may also express HLA-DR in certain disease states characterized by mononuclear cell infiltrates. Previous studies have shown that HK synthesize HLA-DR in response to stimulation by interferon gamma (INF-gamma). The purposes of this study were to define conditions under which cultured HK might express HLA-DR and to compare the HLA-DR synthesis of HK with that of monocytes. HLA-DR expression by HK as determined by indirect immunofluorescence of HK cultures was absent under standard low calcium conditions and remained absent with the addition of calcium, serum, mitogens, and supernatants from Pam-212 cells containing epidermal thymocyte-activating factor. HLA-DR expression in HK was induced by cocultivation with concanavalin A-stimulated peripheral blood mononuclear cells (PBMC), but not unstimulated PBMC. This effect was time-dependent and directly related to the number of PBMC. HLA-DR expression was also induced in a time- and dose-dependent manner by addition of supernatant from stimulated PBMC (SS) or by addition of recombinant INF-gamma but not by addition of interleukin (IL)-1 or IL-2. Induction by either SS or INF-gamma was blocked by an antiserum to INF-gamma. As determined by a semiquantitative immunoprecipitation technique, HLA-DR synthesis by HK was directly related to INF-gamma concentration. The pattern of HLA-DR peptides produced by HK was similar to that of monocytes, but the relative quantity synthesized was far less than that of monocytes.

  4. Understanding hospitality.

    PubMed

    Patten, C S

    1994-03-01

    Bridging patient/"customer" issues and business aspects can be aided through developing a specific nursing basis for hospitality. The ancient practice of hospitality has evolved into three distinct levels: public, personal and therapeutic. Understanding these levels is helpful in integrating various dimensions of guest relations programs in hospitals into a more comprehensive vision. Hospitality issues must become a greater part of today's nursing management.

  5. [Dr. Atkins' dietetic revolution: a critique].

    PubMed

    Hirschel, B

    1977-07-23

    Very fat people die earlier than people of normal weight because hypertension, diabetes and coronary disease are more frequent among the markedly obese. Most obese subjects, however, are only slightly overweight and their mortality is not elevated. Reasons for dieting are more often psychological than somatic. 2. Reducing diets are ineffective because the obese rarely follow them. Total fasting and intestinal bypass may provide better results, but are more dangerous. 3. Atkins' diet eliminates carbohydrates from food without restricting protein and fat intake. Deprived of carbohydrates, the body uses fat for fuel. A small part of metabolized fat is eliminated in the urine as ketone bodies, and this is why such diets are called "ketogenic". They have been known at least since 1863. 4. Caloric loss due to ketonuria does not exceed 100 Cal/day in the non-diabetic. It is maximal during total fasting and cannot be increased by a ketogenic diet. 5. In the short run, such diets produce rapid weight loss due to polyuria. On the other hand, refeeding carbohydrates causes water retention and weight gain. 6. The diet decreases appetite: patients eat less without feeling severe hunger and without measuring their food intake. 7. Orthostatic hypotension, fatigue, and nausea are frequent, despite what Dr. ATKINS claims. 8. The diet increases plasma cholesterol and uric acid. It may be dangerous in diabetes (anorexia, acidosis) and in heart or kidney failure (hypokalemia). 9. The diet, though far from good, is better than the book. ATKINS' theories are at best half-truths, and the results he claims lack credibility. The obese subject's disappointment with traditional reducing diets and the book's hard-sell style account for ATKINS' success.

  6. Hospitals may be bound by terms added in supplier's acceptance of an offer.

    PubMed

    Decker, R

    1992-03-01

    A hospital materials manager reports that a supplier is attempting to hold the hospital to new terms that the supplier added in the acceptance of an offer to buy. The offer to buy was made in the hospital's purchase order. In this dialogue, Dr. Decker develops the law relating to such a transaction.

  7. Pathogenesis of Afa/Dr diffusely adhering Escherichia coli.

    PubMed

    Servin, Alain L

    2005-04-01

    Over the last few years, dramatic increases in our knowledge about diffusely adhering Escherichia coli (DAEC) pathogenesis have taken place. The typical class of DAEC includes E. coli strains harboring AfaE-I, AfaE-II, AfaE-III, AfaE-V, Dr, Dr-II, F1845, and NFA-I adhesins (Afa/Dr DAEC); these strains (i) have an identical genetic organization and (ii) allow binding to human decay-accelerating factor (DAF) (Afa/Dr(DAF) subclass) or carcinoembryonic antigen (CEA) (Afa/Dr(CEA) subclass). The atypical class of DAEC includes two subclasses of strains; the atypical subclass 1 includes E. coli strains that express AfaE-VII, AfaE-VIII, AAF-I, AAF-II, and AAF-III adhesins, which (i) have an identical genetic organization and (ii) do not bind to human DAF, and the atypical subclass 2 includes E. coli strains that harbor Afa/Dr adhesins or others adhesins promoting diffuse adhesion, together with pathogenicity islands such as the LEE pathogenicity island (DA-EPEC). In this review, the focus is on Afa/Dr DAEC strains that have been found to be associated with urinary tract infections and with enteric infection. The review aims to provide a broad overview and update of the virulence aspects of these intriguing pathogens. Epidemiological studies, diagnostic techniques, characteristic molecular features of Afa/Dr operons, and the respective role of Afa/Dr adhesins and invasins in pathogenesis are described. Following the recognition of membrane-bound receptors, including type IV collagen, DAF, CEACAM1, CEA, and CEACAM6, by Afa/Dr adhesins, activation of signal transduction pathways leads to structural and functional injuries at brush border and junctional domains and to proinflammatory responses in polarized intestinal cells. In addition, uropathogenic Afa/Dr DAEC strains, following recognition of beta(1) integrin as a receptor, enter epithelial cells by a zipper-like, raft- and microtubule-dependent mechanism. Finally, the presence of other, unknown virulence factors and the

  8. [DR. SHOSHANA SZKOP-FRENKIEL: THE FIRST FEMALE PLASTIC SURGEON IN ISRAEL].

    PubMed

    Shehory-Rubin, Zipora

    2015-11-01

    In the history of Israeli medicine, Dr. Shoshana Szkop-Frenkiel is regarded as the first plastic surgeon in the country and among the founders of the profession of plastic surgery. This article describes the long road she traveled, from her acceptance into medical studies in Vilna--at a time when the entry of any woman to the faculty of medicine was strictly limited and of Jewish women in particular; her emigration to Eretz Israel and her struggles as she underwent training in internal medicine at the "Hadassah" Hospital in Tel-Aviv, when she was denied training as a surgeon; and up to the moment she was accepted by the plastic surgery unit of the Tel Hashomer Hospital and became the first such female practitioner in Israel. Dr. Shoshana Szkop-Frenkiel thus fulfilled a childhood dream to become a surgeon at a time when women were excluded from surgery on the grounds that it called for "male" characteristics. This article is intended to illustrate the character of a female doctor pursuing a career in surgery during the time of the British Mandate, to illuminate her professional travails in Israel, and to emphasize her important contribution in the field.

  9. Properties of Isolated Galaxies in the SDSS DR2

    NASA Astrophysics Data System (ADS)

    Tucker, D. L.; Allam, S. S.; SDSS Collaboration

    2004-05-01

    We analyze the properties of a sample of ˜4,500 isolated galaxies selected from the SDSS DR2 photometric data following well defined criteria (Tucker & Allam 2003). The results are briefly discussed.

  10. 1. Photocopy of engraved flyer (from the collection of Dr. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photocopy of engraved flyer (from the collection of Dr. Margaret Ballard, Union, West Virginia) H. Bartsch, engraver late 19th century AERIAL VIEW OF TOWN AND ADVERTISING SLOGANS - Red Sulphur Springs, Route 12, Salt Sulphur Springs, Monroe County, WV

  11. Grantee Spotlight: Dr. Kolawole Okuyemi - Improving Cervical Cancer Screening Attitudes

    Cancer.gov

    Dr. Kolawole Okuyumi is studying cervical cancer screening attitudes and behaviors of African immigrants and refugees in Minnesota, and introducing “cancer” and “cervix” to their everyday vocabulary.

  12. GOES-R with Dr. Kathy Sullivan and Tim Samaras

    NASA Video Gallery

    This short video features highlights from a live Nationwide broadcast that took place on April 3, 2012, from the studio of NASA Goddard TV. NOAA’s Deputy Administrator and Chief Scientist Dr. Ka...

  13. Interview with Dr. Omar Khan, noted global health specialist.

    PubMed

    Simmons, Rob; Khubchandani, Jagdish

    2012-07-01

    Dr. Khan has had a distinguished career in global health. He has served as a faculty member at the University of Vermont College of Medicine and Johns Hopkins University School of Public Health. He is currently a family medicine physician at Christiana Care Health System in Newark, Delaware, and is President of the Delaware Academy of Family Physicians. Dr. Khan has authored more than 55 peer-reviewed journal articles and book chapters and has conducted research and lead primary care and public health initiatives in numerous countries. Last year, Dr. Khan also coedited a book titled Megacities and Global Health sponsored by the American Public Health Association with Dr. Gregory Pappas, Deputy Health Commissioner for Washington, DC.

  14. NES Live Video Chat: Dr. John C. Mather

    NASA Video Gallery

    NES welcomed Nobel Prize winner Dr. John C. Mather for a video webchat on May 17, 2011. He spoke about the James Webb Space Telescope and how it gives us a look into the past to see how galaxies ha...

  15. Evolution of the Pediatric and Congenital Heart Surgery Service at Texas Children's Hospital: 1954-2015.

    PubMed

    Fraser, Charles D

    2015-01-01

    Heart surgery at Texas Children's Hospital can trace its origins to the beginning of pediatric and congenital heart surgery. Pioneers in the field--Dr. Denton Cooley and Dr. Dan McNamara--started the program in 1954 at a new pediatric hospital in Houston. Over the past 60 years, what is now Texas Children's Heart Center has grown become one of the leading pediatric heart institutions.

  16. Dr Pugh and the myth of the illicit still.

    PubMed

    Paull, J D

    2014-07-01

    In her valuable history of the arrival of the news of etherisation in Australia and its implementation by many doctors and dentists, titled One Grand Chain, the late Dr Gwen Wilson asserted that the dentist and the doctor who pioneered etherisation in Australia, "Belisario and Pugh, …were charged by the authorities with possession of an illicit still." This paper examines the evidence for the truth or otherwise of this assertion, in relation to Dr Pugh.

  17. A periodontal case report by Dr. S.L. Clemens.

    PubMed

    Maloney, W J

    2010-07-01

    Mark Twain provides a humorous and insightful look into the origins of periodontal therapy and anesthesia in "Happy Memories of the Dental Chair". The main character of this story is Dr. John Riggs, the father of periodontics. Dr. Horace Wells, a pioneer in the field of anesthesia, also appears in the story. Twain presents his autobiographical experiences with dentistry in his literary work in a form that can be seen to be similar to a case report in a professional dental journal.

  18. Muscle building: a scientific workout for Dr. Elisabeth Barton.

    PubMed

    Bain, Lisa J

    2004-01-01

    Dr. Elisabeth Barton spends her lab time building muscle. But no, you won't find her there lifting weights. This Assistant Professor of Anatomy and Cell Biology is working out the science of muscle repair. From the repair of muscles in the face to those in the limbs, Dr. Barton's research investigations are exploring the potential to help such diverse problems as temporomandibular dysfunction (TMD) and muscular dystrophy.

  19. Portrait of Dr. Von Braun with Walt Disney, 1954.

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

  20. [Hospitals' evolution through the ages].

    PubMed

    de Micheli, Alfredo

    2005-01-01

    The predecessor institutions of modern hospitals--Byzantine nosocómeion, European hospitale and Islamic maristan--were dissimilar both in their patients and their aims. The first charitable organizations in West Europe (Rome) and in the East (Cesarea in Cappadocia) were rather hospices. After the collapse of the Western Roman Empire (476 A.D.), some monastic centers were prepared to provide medical assistance to religious and secular patients. Since the XI and XII Centuries in all of Christian Europe the charitable institutions, designated as hospitale, multiplied. Among the Italian ones, the Roman Santo Spirito (Holy Ghost) Hospital, built in the 1201-1204 period, reached a preeminet position. This one soon became the most important of the entire Christendom (archihospital), with a lot of affiliated hospitals in Europe and later in America. The first American hospital, Saint Nicholas Hospital, opened on December 29, 1503 in Santo Domingo, obtained in 1541 its affiliation to the Santo Spirito archihospital. Regarding continental America, the first health centers were established in Mexico: the Immaculate Conception Hospital and the Saint Lazarus Hospital, both established by Hernán Cortés. For its part, clinical teaching was systematized at the Saint Francis Hospital in Padua and by there moved to Leyden. In Mexico, the chair of medical clinics or practical medicine was established in 1806 at the Saint Andrew Hospital. During the XX century, Dr. Ignacio Chávez was the driving force behind the creation of the modern Mexican Health Institutes. These ones are dedicated to the treatment of poor patients, as well as to medical teaching and research.

  1. Mobile robot GPS/DR integrated navigation positioning technique research

    NASA Astrophysics Data System (ADS)

    Wang, Jingkun; Zhang, Yuanliang; Li, Bifu; Chong, Kil To

    2010-01-01

    GPS is widely used for global positioning system. But GPS signal is easily interrupted when it is used alone. DR (dead reckoning) can calculate the position of mobile robots by using direction and speed sensors. However, DR system error can accumulate over time due to the error of electronic compass and odometer sensors. So DR system can't be used separately for a long time. The integrated navigation system combined GPS with DR will effectively integrated advantages of these two systems, higher positioning precision and reliability. In this paper Kalman filter model for GPS/DR integrated navigation system is set up to filter the GPS and DR data. And then the outputs of Kalman filter are inputted to a BP neural network for training. BP neural network is employed to predict next sampling time GPS output and a new Kalman filter based data fusion method is proposed to do the navigation information fusion with encoders and compass system. Simulation is done to validate the proposed fusion method. The simulation result shows the potential of this fusion method for outside used mobile robot navigation. Finally experiments are done to validate the proposed fusion method.

  2. Mobile robot GPS/DR integrated navigation positioning technique research

    NASA Astrophysics Data System (ADS)

    Wang, Jingkun; Zhang, Yuanliang; Li, Bifu; Chong, Kil To

    2009-12-01

    GPS is widely used for global positioning system. But GPS signal is easily interrupted when it is used alone. DR (dead reckoning) can calculate the position of mobile robots by using direction and speed sensors. However, DR system error can accumulate over time due to the error of electronic compass and odometer sensors. So DR system can't be used separately for a long time. The integrated navigation system combined GPS with DR will effectively integrated advantages of these two systems, higher positioning precision and reliability. In this paper Kalman filter model for GPS/DR integrated navigation system is set up to filter the GPS and DR data. And then the outputs of Kalman filter are inputted to a BP neural network for training. BP neural network is employed to predict next sampling time GPS output and a new Kalman filter based data fusion method is proposed to do the navigation information fusion with encoders and compass system. Simulation is done to validate the proposed fusion method. The simulation result shows the potential of this fusion method for outside used mobile robot navigation. Finally experiments are done to validate the proposed fusion method.

  3. DR-current intensity variations during substorm development

    NASA Astrophysics Data System (ADS)

    Zaitseva, S. A.; Drobinina, T. A.; Pudovkin, M. I.

    2003-04-01

    According to the concept dominated by the last time, the intensification of the DR-current takes place during the polar substorm development. In the recent papers Iyemori and Rao claim that geomagnetic storms and substorms are independent processes, and SYM-index (essentially the same as Dst-index) tends to decay after the onset of substorms. In this paper we tried to clear up the cause of this contradiction by studying the connection of ring current development with polar substorms basing on the new data: ASY-, SYM-indices describing asymmetric and symmetric parts of DR-current correspondingly and AL-index as a measure of polar disturbances. It is shown that the hourly-mean SYM- and ASY-indices correlate with AL-index (r=0.63 and 0.69 correspondingly), and the connection between these values becomes worse for strong storms. Besides, at the substorm expansive phase onset, the energy can put mainly to the asymmetric part rather than into symmetric part of DR-current. Empirical Q-index based on solar wind parameters describes the energy input into DR-current; Q correlates rather well with SYM, ASY and AL-indices. Thus the intensifications of polar disturbances and DR-current take place simultaneously and have the same source.At the same time, the proportion in which the solar wind energy is distributed between the DR-current, polar ionosphere and magnetotail depends on the Dst variation phase.

  4. Remaining Sites Verification Package for 132-DR-1, 1608-DR Effluent Pumping Station, Waste Site Reclassification Form 2005-035

    SciTech Connect

    R. A. Carlson

    2005-09-22

    Radiological characterization, decommissioning and demolition of the 132-DR-1 site, 1608-DR Effluent Pumping Station was performed in 1987. The current site conditions achieve the remedial action objectives and the corresponding remedial action goals established in the Remaining Sites ROD. Residual concentrations support future land uses that can be represented by a rural-residential scenario and pose no threat to groundwater or the Columbia River based on RESRAD modeling.

  5. [Historical exploration of Acapulco hospitals, Guerrero, Mexico].

    PubMed

    Fajardo-Ortiz, Guillermo; Salcedo-Alvarez, Rey Arturo

    2006-01-01

    This study attempts to recount the history of the main hospitals of the port of Acapulco from colonial times until the end of the 20th century. The Augustine friars began hospital care at the end of the first part of the 16th century. Later, Bernardino Alvarez (1514?-1584), with the support of the Spanish crown, founded the first formal hospital in Acapulco called Hospital de Nuestra Señora de la Consolación (Our Lady of Consolation Hospital). During the 16th and 17th centuries, the sick were attended by friars, and by the end of the 19th century there were physicians and surgeons. From the end of the Independence War until the end of the 19th century, the port did not have any true hospital. The first degreed physicians and surgeons arrived and resided in Acapulco in 1920. In 1938, the Hospital Civil Morelos (Morelos Civil Hospital) began providing services. It was replaced by the Hospital General de Acapulco (General Hospital of Acapulco). At the fourth decade of the past century the Cruz Roja (Red Cross) was created. In 1957 the hospital services of the Instituto Mexicano del Seguro Social (IMSS, Mexican Institute of Social Security), which was founded in 1963, was inaugurated with the Unidad Medico/Social (Medical and Social Unit) of the IMSS in Acapulco. This began the journey of modernity in Acapulco. In 1992, Hospital Regional Vicente Guerrero (Regional Hospital Vicente Guerrero) of the IMSS, initiated its services. In 1960, medical services for civil workers and their families were housed in the Hospital Civil Morelos (Morelos Civil Hospital). Shortly afterwards, the Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado (ISSSTE, Security and Social Services Institute for State Employees) had their own hospital. During the 20th century, Acapulco has added other hospital services to care for members of the navy and armed forces, as well as for those persons with financial resources for private care.

  6. Overall properties of the Gaia DR1 reference frame

    NASA Astrophysics Data System (ADS)

    Liu, N.; Zhu, Z.; Liu, J.-C.; Ding, C.-Y.

    2017-03-01

    Aims: The first Gaia data release (Gaia DR1) provides 2191 ICRF2 sources with their positions in the auxiliary quasar solution and five astrometric parameters - positions, parallaxes, and proper motions - for stars in common between the Tycho-2 catalogue and Gaia in the joint Tycho-Gaia astrometric solution (TGAS). We aim to analyze the overall properties of Gaia DR1 reference frame. Methods: We compare quasar positions of the auxiliary quasar solution with ICRF2 sources using different samples and evaluate the influence on the Gaia DR1 reference frame owing to the Galactic aberration effect over the J2000.0-J2015.0 period. Then we estimate the global rotation between TGAS with Tycho-2 proper motion systems to investigate the property of the Gaia DR1 reference frame. Finally, the Galactic kinematics analysis using the K-M giant proper motions is performed to understand the property of Gaia DR1 reference frame. Results: The positional comparison between the auxiliary quasar solution and ICRF2 shows negligible orientation and validates the declination bias of -0.1mas in Gaia quasar positions with respect to ICRF2. Galactic aberration effect is thought to cause an offset 0.01mas of the Z axis direction of Gaia DR1 reference frame. The global rotation between TGAS and Tycho-2 proper motion systems, obtained by different samples, shows a much smaller value than the claimed value 0.24mas yr-1. For the Galactic kinematics analysis of the TGAS K-M giants, we find possible non-zero Galactic rotation components beyond the classical Oort constants: the rigid part ωYG = -0.38±0.15mas yr-1 and the differential part ω^primeYG = -0.29±0.19mas yr-1 around the YG axis of Galactic coordinates, which indicates possible residual rotation in Gaia DR1 reference frame or problems in the current Galactic kinematical model. Conclusions: The Gaia DR1 reference frame is well aligned to ICRF2, and the possible influence of the Galactic aberration effect should be taken into consideration

  7. HLA-DR2 Frequency Increase in Severe Aplastic Anemia Patients is Mainly Attributed to the Prevalence of DR15 Subtype.

    PubMed

    Kapustin, Sergey I; Popova, Tamara I; Lyschov, Anton A; Togo, Alexander V; Abdulkadyrov, Kudrat M; Blinov, Michail N

    1997-01-01

    The association between severe aplastic anemia (AA) and DR2 antigen seems to be well established. However, since discrimination between two DR2-associated splits, namely DR15 and DR16, rarely was performed, it remains unclear whether one or both of these subvariants are responsible for AA susceptibility. In this study, we have analyzed the HLA-DR allelic distribution in a group of 37 AA patients of slavic origin from North-Western Russia. The experimental design included PCR-based amplification of DRB-specific sequences, followed by reverse dot-blot hybridization of the biotinylated PCR-product with the set of sequence-specific oligonucleotide probes. HLA-DRB alleles were identified by non-radioactive enzymatic reaction, then standard serological specificities of HLA-DR antigen were estimated according to the WHO nomenclature. Whereas DR15 subtype occurred more often in the patients (23.0% vs. 13.3%, p< 0.05), DR16 split did not show the same tendency. The results, show the overall predominance of HLA-DR2 specificity (DR15+DR16) did not reach statistical significance (24.4% vs.17.5%, p<0.2). Thus, we conclude that repeatedly reported DR2 frequency increase in AA patients is mainly attributed to the prevalence of DR15 subtype.

  8. Adapting the neurology area of the Gustavo Fricke Hospital

    NASA Astrophysics Data System (ADS)

    Ankelen, A.; González, S.; Aguirre, L.

    2007-11-01

    Within the framework of the subject Clinical Engineering taught at Hospital Dr. Gustavo Fricke of Viña del Mar Chile, we were assigned to undertake a detailed study on the quality of the electrical power main supply of the Neurology Department, on account of reported malfunctioning of some equipment used in this unit. The study results indicated that the problems occurred only in a device for auditory evoked potentials device and, contrary to what was expected, the problem was unrelated to the quality of the electrical main supply. It was also found that the cause for the problem was electromagnetic interference (EMI) emitted from the system's very own components. To solve the problem, we built a Faraday Cage for the signal-processing unit and increased the separating distance among the various system components. This approach enhanced system performance and significantly improved the recorded signals of patients. The solution adopted from this experience was suggested to others health care centers of our country that had been experiencing similar difficulties with the same type of medical equipment.

  9. Dr Louis T. Wright and the NAACP: pioneers in hospital racial integration.

    PubMed

    Reynolds, P P

    2000-06-01

    Louis Tompkins Wright, the son of a man born into slavery, was an outstanding African American surgeon who devoted his life to the racial integration of health care in the United States. Despite the fact that both his father and stepfather were physicians, despite his innate intellectual gifts and disciplined character, Wright experienced discrimination throughout his life and career. This experience led him to fight for the rights of African Americans, both health care professionals and patients. In addition to making numerous contributions in the fields of surgery and infectious disease, Wright held leadership positions in the National Association for the Advancement of Colored People for more than 20 years, leaving a legacy of equity for African Americans in medical education and in health care.

  10. Determining the variability in O(2) saturation measurements in devices of the "Dr. Guillermo Rawson" hospital.

    PubMed

    Munoz Zapata, F J; Pulenta, L; Bustamante, P A; Avila Perona, E M

    2015-08-01

    Measurement of oxygen saturation is a noninvasive monitoring method that has had a major impact on patient care in both emergency and ambulatory situations. It is an important parameter in neonatology field, especially in newborn preterm births, and in anesthetic and surgical procedures.

  11. Dr Louis T. Wright and the NAACP: pioneers in hospital racial integration.

    PubMed Central

    Reynolds, P P

    2000-01-01

    Louis Tompkins Wright, the son of a man born into slavery, was an outstanding African American surgeon who devoted his life to the racial integration of health care in the United States. Despite the fact that both his father and stepfather were physicians, despite his innate intellectual gifts and disciplined character, Wright experienced discrimination throughout his life and career. This experience led him to fight for the rights of African Americans, both health care professionals and patients. In addition to making numerous contributions in the fields of surgery and infectious disease, Wright held leadership positions in the National Association for the Advancement of Colored People for more than 20 years, leaving a legacy of equity for African Americans in medical education and in health care. PMID:10846505

  12. Hospital philanthropy.

    PubMed

    Smith, Dean G; Clement, Jan P

    2013-01-01

    It remains an open question whether hospital spending on fundraising efforts to garner philanthropy is a good use of funds. Research and industry reports provide conflicting results. We describe the accounting and data challenges in analysis of hospital philanthropy, which include measurement of donations, measurement of fundraising expenses, and finding the relationships among organizations where these cash flows occur. With these challenges, finding conflicting results is not a surprise.

  13. Study of photoluminescence properties of thin films DR1

    SciTech Connect

    Herman, Ulya, Naily

    2015-09-30

    Fabrication of thin films DR1 have been carried out by the EFA-PDF (Electric Field-Assisted Physical Vapor Deposition) method to obtain films with parallel dipole arrangement. Molecular deposition process is performed by applying an electric field that is placed between the substrate ITO (Indium Tin Oxide) and copper mesh. The resulting films were characterized by using a spectrofluorometer. Analysis of the emission spectrum, indicate that DR1 molecules in the film oriented perpendicular to the substrate and arranged in parallel order (H-aggregate). As an effect, the peak of the emission spectrum appears stronger along with the increase of electric field strength.

  14. Study of photoluminescence properties of thin films DR1

    NASA Astrophysics Data System (ADS)

    Herman, Ulya, Naily

    2015-09-01

    Fabrication of thin films DR1 have been carried out by the EFA-PDF (Electric Field-Assisted Physical Vapor Deposition) method to obtain films with parallel dipole arrangement. Molecular deposition process is performed by applying an electric field that is placed between the substrate ITO (Indium Tin Oxide) and copper mesh. The resulting films were characterized by using a spectrofluorometer. Analysis of the emission spectrum, indicate that DR1 molecules in the film oriented perpendicular to the substrate and arranged in parallel order (H-aggregate). As an effect, the peak of the emission spectrum appears stronger along with the increase of electric field strength.

  15. The development of a specialty: an interview with Dr. Mark C. Rogers, a pioneering pediatric intensivist.

    PubMed

    Mai, Christine L; Firth, Paul G; Ahmed, Zulfiqar; Rodriguez, Samuel; Yaster, Myron

    2014-09-01

    Dr. Mark C. Rogers (1942-), Professor of Anesthesiology, Critical Care Medicine, and Pediatrics at the Johns Hopkins University, was recruited by the Department of Pediatrics at Johns Hopkins Hospital in 1977 to become the first director of its pediatric intensive care unit. After the dean of the medical school appointed him to chair the Department of Anesthesia in 1979, Rogers changed the course and culture of the department. He renamed it the Department of Anesthesiology and Critical Care Medicine, and developed a long-term strategy of excellence in clinical care, research, and education. However, throughout this period, he never lost his connection to pediatric intensive care. He has made numerous contributions to pediatric critical care medicine through research and his authoritative textbook, Rogers' Textbook of Pediatric Intensive Care. He established a training programme that has produced a plethora of leaders, helped develop the pediatric critical care board examination, and initiated the first World Congress of Pediatric Intensive Care. Based on a series of interviews with Dr. Rogers, this article reviews his influential career and the impact he made on developing pediatric critical care as a specialty.

  16. STATISTICAL STUDY OF 2XMMi-DR3/SDSS-DR8 CROSS-CORRELATION SAMPLE

    SciTech Connect

    Zhang Yanxia; Zhou Xinlin; Zhao Yongheng; Wu Xuebing

    2013-02-01

    Cross-correlating the XMM-Newton 2XMMi-DR3 catalog with the Sloan Digital Sky Survey (SDSS) Data Release 8, we obtain one of the largest X-ray/optical catalogs and explore the distribution of various classes of X-ray emitters in the multidimensional photometric parameter space. Quasars and galaxies occupy different zones while stars scatter in them. However, X-ray active stars have a certain distributing rule according to spectral types. The earlier the type of stars, the stronger its X-ray emitting. X-ray active stars have a similar distribution to most stars in the g - r versus r - i diagram. Based on the identified samples with SDSS spectral classification, a random forest algorithm for automatic classification is performed. The result shows that the classification accuracy of quasars and galaxies adds up to more than 93.0% while that of X-ray emitting stars only amounts to 45.3%. In other words, it is easy to separate quasars and galaxies, but it is difficult to discriminate X-ray active stars from quasars and galaxies. If we want to improve the accuracy of automatic classification, it is necessary to increase the number of X-ray emitting stars, since the majority of X-ray emitting sources are quasars and galaxies. The results obtained here will be used for the optical spectral survey performed by the Large sky Area Multi-Object fiber Spectroscopic Telescope (LAMOST, also named the Guo Shou Jing Telescope), which is a Chinese national scientific research facility operated by the National Astronomical Observatories, Chinese Academy of Sciences.

  17. DR with a DSLR: Digital Radiography with a Digital Single-Lens Reflex camera

    PubMed Central

    Fan, Helen; Durko, Heather L.; Moore, Stephen K.; Moore, Jared; Miller, Brian W.; Furenlid, Lars R.; Pradhan, Sunil; Barrett, Harrison H.

    2010-01-01

    An inexpensive, portable digital radiography (DR) detector system for use in remote regions has been built and evaluated. The system utilizes a large-format digital single-lens reflex (DSLR) camera to capture the image from a standard fluorescent screen. The large sensor area allows relatively small demagnification factors and hence minimizes the light loss. The system has been used for initial phantom tests in urban hospitals and Himalayan clinics in Nepal, and it has been evaluated in the laboratory at the University of Arizona by additional phantom studies. Typical phantom images are presented in this paper, and a simplified discussion of the detective quantum efficiency of the detector is given. PMID:21516238

  18. [Dr. Joseph Chazanowicz (1844-1919) and the National Library in Jerusalem].

    PubMed

    Ohry, Avi

    2014-01-01

    Dr. Joseph Chazanowicz (1844-1919), was a Russian physician, and founder of the Jewish National Library in JerusaLem. After completing his studies at the Jewish school and at the gymnasium of Grodno, Chazanowicz went to Königsberg, Germany to study medicine and finished his studies in 1872. Returning to Russia, he began to practice at Byelostok's Jewish hospital. Chazanowicz founded the Hovevei Ziyyon ["Lovers of Zion"] society and also the Linat Ha-Zedek ("Hospice for the Poor")--caring for the poor. In 1890 he visited Palestine and conceived the idea of founding a library in Jerusalem, together with the B'nai B'rith organization. In 1896 he sent his large collection of books, amounting to nearly 10,000 volumes, to Jerusalem as the beginning of the Abarbanel library. The enlargement of this library and the collection of funds to erect a special building for it became the life-work of Chazanowicz.

  19. [The practice of medicine at the end of the Second Empire: according to a book, appearing in 1865, by Dr. Camille Delvaille, physician in Bayonne].

    PubMed

    Marx, P

    1999-01-01

    Dr Camille Delvaille (1835-1904) was a physician in Bayonne. He wrote many books about scientific problems and social medicine; he was one of the first to suggest medical control at school. In a book, written in 1865, he studied everyday practice in France. He complained against the "Officiers de Sante" who exercised medicine mainly in the countryside but were not doctors and had followed very short medical studies. Dr Delvaille deplored that it meant two kinds of cares: doctors for top people and Officiers de Sante for poor patients. In fact, the end of the Officiat de Sante occured only in 1892. Dr Delvaille studied also some problems related to medical demography; he purposed for our country a law cutting down foreign practice in France. Then, he put forward nomination of Professors or hospital's physicians through an examination instead of routine cooptation. Some of his minds are ahead and were applied later.

  20. Dr. David Sawyer, Mickey Mouse and Dr. David Brown attend a ceremony at Ronald McNair Middle School

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. David Sawyer (left), Superintendent of the Brevard County School District, Mickey Mouse, and Dr. David Brown, a NASA astronaut, attend a tribute to NASA astronaut Ronald McNair held in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. During the tribute, Walt Disney World presented a portrait of McNair to the school, which had previously been renamed for the fallen astronaut. McNair was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  1. 28. View of data test area for DR data take ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. View of data test area for DR data take off set operators panel and cabinet at second floor of transmitter building no. 102 in MIP area. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  2. 39. View of checkout indicator computer console for DR beams, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. View of checkout indicator computer console for DR beams, TR chains, and special checkout target control located in CSMR in transmitter building no. 102. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  3. 3. View of middle DR 2 antenna looking north 30 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. View of middle DR 2 antenna looking north 30 degrees west and showing radar scanner building no. 105 east face through antenna. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  4. 2. View of southerly DR 1 antenna looking north 25 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. View of southerly DR 1 antenna looking north 25 degrees west and and showing radar scanner building no. 105 east face through antenna. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  5. 7. View of DR 3 antenna typical front stay concrete ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. View of DR 3 antenna typical front stay concrete showing embedment anchors, foundation steel base plate, vertical member with small diameter turnbuckles, antenna assembly in background, and story board for scale. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  6. Dr. Chad E. Finn, 2013 Wilder Medal Recipient

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dr. Chad Finn took over the leadership of the USDA-ARS small fruit breeding program in Corvallis, Oregon in 1993 after three years working as an extension horticulturist in the Department of Horticulture at the University of Missouri, Columbia. Since taking over this program he has developed what is...

  7. Dr Skateboard's Action Science: Teaching Physics in Context

    ERIC Educational Resources Information Center

    Robertson, William H.

    2009-01-01

    In order to create student interest and promote new connections to the understanding of fundamental physics concepts, there is a need for new approaches and methods that are both contemporary and relevant. Dr Skateboard's Action Science, a curriculum supplement comprising video instruction and classroom activities, is an example that focuses on…

  8. Oxygen and Metastasis: A Conversation with Dr. Nick Restifo

    Cancer.gov

    Dr. Nick Restifo, a senior investigator in NCI’s Center for Cancer Research, discusses his recently published study finding that Oxygen, a molecule necessary for life, paradoxically aids cancer metastasis to the lung by impairing cancer-killing immune cells.

  9. Working To Make a Difference: Interview with Dr. James Alatis.

    ERIC Educational Resources Information Center

    Rosenthal, Marilyn

    2002-01-01

    This interview with Dr. James Alatis, dean emeritus in the School of Languages and Linguistics of Georgetown University, covers among other things his influence in the founding of the Teacher of English to Speakers of Other Languages (TESOL) organization, how the organization has changed since its founding, his current goals for TESOL, his…

  10. Keeping the Dream Alive. Dr. Martin Luther King, Jr.

    ERIC Educational Resources Information Center

    Cassells, Linda; And Others

    1993-01-01

    Presents activities for teaching elementary students about Dr. Martin Luther King's life, the civil rights movement, and King's accomplishments. Suggestions include shoebox dioramas, acronym games, oral histories, multicultural awareness activities, pledge cards, community service projects, special commemorative ceremonies, and a book of dreams.…

  11. A Dr. Martin Luther King, Jr. Curriculum: Playing the Dream.

    ERIC Educational Resources Information Center

    Clemens, Sydney Gurewitz

    1988-01-01

    Discusses curriculum for young children centered around the beliefs and teachings of Dr. Martin Luther King, Jr. His works are interpreted in a human rights context in which children find their voice in the peaceable resolution of everyday conflicts. Describes the Child of the Day program. (Author/RWB)

  12. Dr. Martin Luther King, Jr. Washington State Resource Guide.

    ERIC Educational Resources Information Center

    Washington Office of the State Superintendent of Public Instruction, Olympia, WA. Div. of Instructional Programs and Services.

    The Washington State Resource Guide on Martin Luther King, Jr., supplies a wide variety of materials for use with all grade levels in classroom and assembly presentations in public schools. The goal is for every child enrolled in Washington State schools to learn about Dr. King during the days of January 15 to January 17. Resolutions supporting an…

  13. Dr. Martin Luther King: A Unit for Primary Grades.

    ERIC Educational Resources Information Center

    Sweet, Kelli

    1986-01-01

    Presents a unit consisting of 4 lessons which focus on Dr. Martin Luther King, Jr.'s childhood, his adult life and family, his civil rights work, and the national holiday which commemorates his birthday. Each lesson features specific objectives, learning activities, and instructional guidelines for the teacher. (TRS)

  14. Trial by Newspaper: The Strange Case of Dr. Karl Muck.

    ERIC Educational Resources Information Center

    Kagan, Sheldon S.

    1993-01-01

    Examines the case of Dr. Karl Muck, conductor of the Boston Symphony Orchestra who was accused of espionage in 1917. Suggests that the espionage charge was a fiction created by newspapers, beginning with "The Providence Journal." Concludes that Muck admitted to being a spy rather than reveal the name of the woman with whom he had an…

  15. Bullying Among Teenage Girls: An Interview with Dr. Harriet Mosatche

    ERIC Educational Resources Information Center

    Prevention Researcher, 2004

    2004-01-01

    Dr. Harriet Mosatche is an advice columnist on a web site for teen girls, as well as the Senior Director of Research and Programs at the Girl Scouts of the USA. Because of these dual roles, she has a unique perspective on the bullying issue. In this interview she answers a number of questions about bullying among teenage girls, including how boys…

  16. Improving College Students English Learning with Dr. Eye Android Mid

    ERIC Educational Resources Information Center

    Yang, Ju Yin; Che, Pei-Chun

    2015-01-01

    This paper investigates college students' English language learning through use of Dr. Eye Android handheld mobile Internet device (MID). Compared to related studies, students' English learning using MIDs has not been evaluated and fully understood in the field of higher education. Quantitatively, the researchers used TOEIC pretest and posttest to…

  17. Focus on Fitness: Q&A with Dr. Greene

    ERIC Educational Resources Information Center

    Greene, Alan

    2005-01-01

    Dr. Greene answers the following question in this brief article focusing on fitness: Everyone knows that children need plenty of exercise to stay healthy--But what does "fitness" really involve for young children? Following this discussion, the topics presented include: snack of the month; nutrition fact; and activities, "Move to the Music" and…

  18. Dr. Edward de Bono's Six Thinking Hats and Numeracy

    ERIC Educational Resources Information Center

    Paterson, Anne

    2006-01-01

    In education, the term "metacognition" describes thinking about thinking. Within mathematics, the term "metacomputation" describes thinking about computational methods and tools. This article shows how Dr. Edward de Bono's Six Thinking Hats can be used to demonstrate metacognition and metacomputation in the primary classroom. The article suggests…

  19. 6. View of DR 3 antenna typical backstay concrete stanchion ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. View of DR 3 antenna typical back-stay concrete stanchion showing embedded anchors and structural steel leg with pin attachment. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  20. The Effects of Dr. Oz on Health Behaviors and Attitudes

    ERIC Educational Resources Information Center

    Crouch, Elizabeth; Dickes, Lori A.; Davis, Amanda; Zarandy, Joy

    2016-01-01

    Background: Consumption of social media has quickly evolved into a primary source of health information for many consumers. This seems to be particularly true for individuals seeking to modify chronic health conditions like weight loss, obesity, and obesity-related diseases. Purpose: This study explores whether watching Dr. Oz weight loss episodes…

  1. Dr. von Braun With a Model of a Launch Vehicle

    NASA Technical Reports Server (NTRS)

    1950-01-01

    Dr. von Braun stands beside a model of the upper stage (Earth-returnable stage) of the three-stage launch vehicle built for the series of the motion picture productions of space flight produced by Walt Disney in the mid-1950's.

  2. 18. View from DR 2 antenna looking south 45 degrees ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. View from DR 2 antenna looking south 45 degrees west to backside transmitter building 101 and in left foreground showing site well system building. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  3. The life and legacy of Dr. Lee Baldwin

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This paper outlines the life and legacy of the late Dr. Ransom L. Baldwin, V. The purpose was to highlight the impact his teaching and research had on the international energy and protein metabolism communities at their fourth international conference. The paper will be presented at the outset of ...

  4. Dynamic Star Formation in the Massive DR21 Filament

    SciTech Connect

    Schneider, N.; Csengeri, T.; Bontemps, S.; Motte, F.; Simon, R.; Hennebelle, P.; Federrath, C.; Klessen, R.; /ZAH, Heidelberg /KIPAC, Menlo Park

    2010-08-25

    The formation of massive stars is a highly complex process in which it is unclear whether the star-forming gas is in global gravitational collapse or an equilibrium state supported by turbulence and/or magnetic fields. By studying one of the most massive and dense star-forming regions in the Galaxy at a distance of less than 3 kpc, i.e. the filament containing the well-known sources DR21 and DR21(OH), we attempt to obtain observational evidence to help us to discriminate between these two views. We use molecular line data from our {sup 13}CO 1 {yields} 0, CS 2 {yields} 1, and N{sub 2}H{sup +} 1 {yields} 0 survey of the Cygnus X region obtained with the FCRAO and CO, CS, HCO{sup +}, N{sub 2}H{sup +}, and H{sub 2}CO data obtained with the IRAM 30m telescope. We observe a complex velocity field and velocity dispersion in the DR21 filament in which regions of the highest column-density, i.e., dense cores, have a lower velocity dispersion than the surrounding gas and velocity gradients that are not (only) due to rotation. Infall signatures in optically thick line profiles of HCO{sup +} and {sup 12}CO are observed along and across the whole DR21 filament. By modelling the observed spectra, we obtain a typical infall speed of {approx}0.6 km s{sup -1} and mass accretion rates of the order of a few 10{sup -3} M{sub {circle_dot}} yr{sup -1} for the two main clumps constituting the filament. These massive clumps (4900 and 3300 M{sub {circle_dot}} at densities of around 10{sup 5} cm{sup -3} within 1 pc diameter) are both gravitationally contracting. The more massive of the clumps, DR21(OH), is connected to a sub-filament, apparently 'falling' onto the clump. This filament runs parallel to the magnetic field. Conclusions. All observed kinematic features in the DR21 filament (velocity field, velocity dispersion, and infall), its filamentary morphology, and the existence of (a) sub-filament(s) can be explained if the DR21 filament was formed by the convergence of flows on large

  5. Six new DR52-associated DRB1 alleles, three of DR8, two of DR11, and one of DR6, reflect a variety of mechanisms which generate polymorphism in the MHC.

    PubMed

    Smith, A G; Nelson, J L; Regen, L; Guthrie, L A; Donadi, E; Mickelson, E M; Hansen, J A

    1996-08-01

    We have sequenced DNA from six new DR52-associated DRB1 alleles initially detected by PCR/SSOP analysis. Three DR8 associated alleles differed from previously known alleles by single nucleotide substitutions. DRB1*0807 and DRB1*0811 both vary from DRB1*08021 at codon 57 resulting in two different amino acids at this residue. DRB1*0807 was identified in samples of Brazilian origin while *0811 was identified among samples from the Tlingit Native American population of Southeast Alaska. DRB1*0814, identified in a family of Chinese origin, differed from DRB1*08032 at codon 12 at both the nucleotide and the amino acid level. In addition, two alleles of DR11, DRB1*1113 and *1119, were each detected in Caucasian individuals. DRB1*1113 differs from other DR11 alleles at codons 37, 67, 70 and 74, while DRB1*1119 differs from *1101 by a single nucleotide substitution at codon 67. Finally, DRB1*1418 was detected in a sample from an Asian or Pacific Islander and shares sequences with several other DR52-associated DRB1 alleles. These six DRB1 alleles appear to have been generated by either gene conversion events, DRB1*1113 and *1418, or by point mutations, DRB1*0814, *0807, *0811 and *1119, although the single nucleotide substitutions found in the latter three alleles are also present in at least one other DRB1 allele and, therefore, could have been the product of gene conversions.

  6. Social contract of academic medical centres to the community: Dr Howard Atwood Kelly (1858-1943), a historical perspective.

    PubMed

    Allen, Paul

    2016-05-01

    Academic medical centres have traditionally been bastions of teaching and research. Outreach to the community at large and involvement in community affairs have sometimes been lacking in the overall mission and activities of academic medical centres. This paper provides an historical perspective first on the numerous achievements of a physician and surgeon and then on the topic of involvement in community affairs by reviewing the many contributions of America's pioneer gynaecological surgeon and one of the four physician founders of the Johns Hopkins Hospital and School of Medicine in 1889 - Dr Howard Atwood Kelly.

  7. Dr Percy Charles Edward d'Erf Wheeler (1859-1944): a notable medical missionary of the Holy Land.

    PubMed

    Perry, Yaron; Lev, Efraim

    2008-05-01

    Dr Percy Charles Edward d'Erf Wheeler, a medical missionary of the London Society for Promoting Christianity Amongst the Jews, spent 24 years (1885-1909) as head of the English medical institution in Jerusalem. Wheeler dedicated the years he served in Palestine to promote the medical condition of the Jews as a means of missionary work. The most significant of his achievements was his leading role in the founding of the new British Hospital for the Jews in Jerusalem, the flagship of the British presence in Palestine, to be inaugurated in 1897.

  8. 78 FR 29781 - Before Administrative Judges: Ronald M. Spritzer, Chairman, Dr. Anthony J. Baratta, Dr. Randall J...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-21

    ... COMMISSION Atomic Safety and Licensing Board Before Administrative Judges: Ronald M. Spritzer, Chairman, Dr... submitted to: Mail: Administrative Judge Ronald M. Spritzer, Atomic Safety and Licensing Board Panel, Mail... statement should be sent to the Chairman of this Licensing Board as follows: Mail: Administrative...

  9. Hospitality Management.

    ERIC Educational Resources Information Center

    College of the Canyons, Valencia, CA.

    A project was conducted at College of the Canyons (Valencia, California) to initiate a new 2-year hospitality program with career options in hotel or restaurant management. A mail and telephone survey of area employers in the restaurant and hotel field demonstrated a need for, interest in, and willingness to provide internships for such a program.…

  10. Hospital finance.

    PubMed

    Herman, M J

    1998-01-01

    This article summarizes key areas of focus for the analysis of risk in the hospital segment of the health care industry. The article is written from a commercial bank lending perspective. Both for-profit (C-corporations) and 501 (c)(3) not-for-profit segments are addressed.

  11. Academic Hospitality

    ERIC Educational Resources Information Center

    Phipps, Alison; Barnett, Ronald

    2007-01-01

    Academic hospitality is a feature of academic life. It takes many forms. It takes material form in the hosting of academics giving papers. It takes epistemological form in the welcome of new ideas. It takes linguistic form in the translation of academic work into other languages, and it takes touristic form through the welcome and generosity with…

  12. Functional polymorphism of each of the two HLA-DR beta chain loci demonstrated with antigen-specific DR3- and DRw52-restricted T cell clones

    PubMed Central

    1988-01-01

    HLA-DR3- and HLA-DRw52-associated functional polymorphism was investigated with selected tetanus toxoid (TT)-specific T cell clones. We have shown earlier that HLA-DR antigens are encoded by two distinct loci, DR beta I and DR beta III. The alloantigenic determinant(s) defined by the serological HLA-DR3 specificity map to the former, while the supratypic HLA-DRw52 determinants map to DR beta III. Furthermore, we have recently recognized by DNA sequencing three alleles of HLA- DRw52 at locus DR beta III, referred to as 52 a, b, and c. Our objective was to correlate the pattern of T cell restriction with the gene products of individual DR beta chain loci and with the three newly described alleles of locus DR beta III. Among the selected T cell clones, 5 reacted exclusively when TT was presented by HLA-DR3+ APCs (TT-DR3-APC). In contrast, two T cell clones were stimulated by TT- DRw52-APC. More specifically, these two T cell clones (Clones 10 and 16) were stimulated by different subsets of TT-DRw52-APC. Clone 16 responded to some DR3 and TT-DRw6-APC, while clone 10 was stimulated by other TT-DR3 and TT-DRw6, and all TT-DR5-APC. This same pattern of DRw52 restriction was found in panel, as well as in family studies. Because this suggested a correlation with the pattern of DRw52 polymorphism observed earlier by DNA sequencing and oligonucleotide hybridization, the APC used in these experiments were typed for the 52 a, b, and c alleles of locus DR beta III by allele-specific oligonucleotide probes. This distribution overlapped exactly with the stimulation pattern defined by the T cell clones. Clone 16 responded to TT-52a-APC, clone 10 to TT-52b-APC, and both clones to a TT-52c-APC. The response of the T cell clones was inhibited differentially by mAbs to DR. Raising TT concentration, or increasing HLA-class II expression with INF-gamma both affected the magnitude of response of the TT- specific clones but did not modify their specificities. These results demonstrate that

  13. Sampling From the Proteome to the Human Leukocyte Antigen-DR (HLA-DR) Ligandome Proceeds Via High Specificity*

    PubMed Central

    Mommen, Geert P. M.; Marino, Fabio; Meiring, Hugo D.; Poelen, Martien C. M.; van Gaans-van den Brink, Jacqueline A. M.; Mohammed, Shabaz; Heck, Albert J. R.; van Els, Cécile A. C. M.

    2016-01-01

    Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4+ T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented peptides, using hybrid mass spectrometry-based peptide fragmentation techniques on a ligandome sample isolated from matured human monocyte-derived dendritic cells (DC). The reported data set constitutes nearly 14 thousand unique high-confident peptides, i.e. the largest single inventory of human DC derived HLA-DR ligands to date. From a technical viewpoint the most prominent finding is that no single peptide fragmentation technique could elucidate the majority of HLA-DR ligands, because of the wide range of physical chemical properties displayed by the HLA-DR ligandome. Our in-depth profiling allowed us to reveal a strikingly poor correlation between the source proteins identified in the HLA class II ligandome and the DC cellular proteome. Important selective sieving from the sampled proteome to the ligandome was evidenced by specificity in the sequences of the core regions both at their N- and C- termini, hence not only reflecting binding motifs but also dominant protease activity associated to the endolysosomal compartments. Moreover, we demonstrate that the HLA-DR ligandome reflects a surface representation of cell-compartments specific for biological events linked to the maturation of monocytes into antigen presenting cells. Our results present new perspectives into the complex nature of the HLA class II system and will aid future immunological studies in characterizing the full breadth of potential CD4+ T cell epitopes relevant in health and disease. PMID:26764012

  14. Strong association between microsatellites and an HLA-B, DR haplotype (B18-DR3): Implication for microsatellite evolution

    SciTech Connect

    Crouau-Roy, B.; Bouzekri, N.; Clayton, J.

    1996-09-01

    The HLA haplotype B18-DR3 has a widespread geographical distribution, but has its greatest frequencies in Southern Europe, probably vestigial of the earliest populations of this region, particularly in the Pays Basque and Sardinia. This haplotype is of medical significance, being that most implicated as a factor of risk in insulin-dependent diabetes mellitus. In this study, the closely linked microsatellite markers (TNFa,b,c) in the region of the tumor necrosis factor (TNF) genes have been used in an attempt to subtype this haplotype in the two populations and/or in healthy and diabetic populations. A total of 79 HLA-B18-DR3 haplotypes were analyzed: 54 in Basques (12 from healthy individuals and 42 from diabetics or their first-degree relatives) and 25 in Sardinians (13 from healthy and 13 from diabetic individuals). The TNF haplotype a1-b5-c2 is completely associated with B18-DR3 in both populations. The homogeneity of the B18-DR3 haplotype in two ethnically pure populations implies stability in evolution, which suggest that the mutation rate of these microsatellite markers must be less than is usually assumed (i.e., {approximately} 5x10{sup {minus}6} per site per generation). Such markers should be powerful tools for studying genetic drift and admixture of populations, but it remains to be established whether this stability is a rule for all microsatellites in HLA haplotypes or whether or whether it is restricted to some microsatellites and/or some HLA haplotypes. The population genetics of those microsatellites associated with HLA B18-DR3 was also studied in a random sample of the Basque population. 44 refs., 3 tabs.

  15. Sampling From the Proteome to the Human Leukocyte Antigen-DR (HLA-DR) Ligandome Proceeds Via High Specificity.

    PubMed

    Mommen, Geert P M; Marino, Fabio; Meiring, Hugo D; Poelen, Martien C M; van Gaans-van den Brink, Jacqueline A M; Mohammed, Shabaz; Heck, Albert J R; van Els, Cécile A C M

    2016-04-01

    Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4(+)T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented peptides, using hybrid mass spectrometry-based peptide fragmentation techniques on a ligandome sample isolated from matured human monocyte-derived dendritic cells (DC). The reported data set constitutes nearly 14 thousand unique high-confident peptides,i.e.the largest single inventory of human DC derived HLA-DR ligands to date. From a technical viewpoint the most prominent finding is that no single peptide fragmentation technique could elucidate the majority of HLA-DR ligands, because of the wide range of physical chemical properties displayed by the HLA-DR ligandome. Our in-depth profiling allowed us to reveal a strikingly poor correlation between the source proteins identified in the HLA class II ligandome and the DC cellular proteome. Important selective sieving from the sampled proteome to the ligandome was evidenced by specificity in the sequences of the core regions both at their N- and C- termini, hence not only reflecting binding motifs but also dominant protease activity associated to the endolysosomal compartments. Moreover, we demonstrate that the HLA-DR ligandome reflects a surface representation of cell-compartments specific for biological events linked to the maturation of monocytes into antigen presenting cells. Our results present new perspectives into the complex nature of the HLA class II system and will aid future immunological studies in characterizing the full breadth of potential CD4(+)T cell epitopes relevant in health and disease.

  16. Seoul National University Bundang Hospital's Electronic System for Total Care

    PubMed Central

    Yoo, Sooyoung; Lee, Kee Hyuck; Lee, Hak Jong; Ha, Kyooseob; Lim, Cheong; Chin, Ho Jun; Yun, Jonghoar; Cho, Eun-Young; Chung, Eunja; Baek, Rong-Min; Chung, Chin Youb; Wee, Won Ryang; Lee, Chul Hee; Lee, Hai-Seok; Byeon, Nam-Soo

    2012-01-01

    Objectives Seoul National University Bundang Hospital, which is the first Stage 7 hospital outside of North America, has adopted and utilized an innovative and emerging information technology system to improve the efficiency and quality of patient care. The objective of this paper is to briefly introduce the major components of the SNUBH information system and to describe our progress toward a next-generation hospital information system (HIS). Methods SNUBH opened in 2003 as a fully digital hospital by successfully launching a new HIS named BESTCare, "Bundang hospital Electronic System for Total Care". Subsequently, the system has been continuously improved with new applications, including close-loop medication administration (CLMA), clinical data warehouse (CDW), health information exchange (HIE), and disaster recovery (DR), which have resulted in the achievement of Stage 7 status. Results The BESTCare system is an integrated system for a university hospital setting. BESTCare is mainly composed of three application domains: the core applications, an information infrastructure, and channel domains. The most critical and unique applications of the system, such as the electronic medical record (EMR), computerized physician order entry (CPOE), clinical decision support system (CDSS), CLMA, CDW, HIE, and DR applications, are described in detail. Conclusions Beyond our achievement of Stage 7 hospital status, we are currently developing a next-generation HIS with new goals of implementing infrastructure that is flexible and innovative, implementing a patient-centered system, and strengthening the IT capability to maximize the hospital value. PMID:22844650

  17. Star Formation in the DR21 Region (B)

    NASA Technical Reports Server (NTRS)

    2004-01-01

    [figure removed for brevity, see original site] Annotated mosaic

    Hidden behind a shroud of dust in the constellation Cygnus is an exceptionally bright source of radio emission called DR21. Visible light images reveal no trace of what is happening in this region because of heavy dust obscuration. In fact, visible light is attenuated in DR21 by a factor of more than 10,000,000,000,000,000,000,000,000,000,000,000,000,000 (ten thousand trillion heptillion).

    New images from NASA's Spitzer Space Telescope allow us to peek behind the cosmic veil and pinpoint one of the most massive natal stars yet seen in our Milky Way galaxy. The never-before-seen star is 100,000 times as bright as the Sun. Also revealed for the first time is a powerful outflow of hot gas emanating from this star and bursting through a giant molecular cloud.

    The upper image is a large-scale mosaic assembled from individual photographs obtained with the InfraRed Array Camera (IRAC) aboard Spitzer. The image covers an area about two times that of a full moon. The mosaic is a composite of images obtained at mid-infrared wavelengths of 3.6 microns (blue), 4.5 microns (green), 5.8 microns (orange) and 8 microns (red). The brightest infrared cloud near the top center corresponds to DR21, which presumably contains a cluster of newly forming stars at a distance of 10,000 light-years.

    Protruding out from DR21 toward the bottom left of the image is a gaseous outflow (green), containing both carbon monoxide and molecular hydrogen. Data from the Spitzer spectrograph, which breaks light into its constituent individual wavelengths, indicate the presence of hot steam formed as the outflow heats the surrounding molecular gas. Outflows are physical signatures of processes that create supersonic beams, or jets, of gas. They are usually accompanied by discs of material around the new star, which likely contain the materials from which future planetary systems are formed. Additional newborn stars

  18. Redox pioneer: Professor Wulf Dröge.

    PubMed

    Kinscherf, Ralf

    2011-06-01

    Dr. Wulf Dröge is recognized here as a redox pioneer because he has published as first author an article on antioxidant/redox biology that has been cited more than 2000 times and over 10 articles that have been cited more than 100 times. One of the key discoveries (1987) was the stimulatory effect of superoxide radicals and hydrogen peroxide on lymphocyte functions, which triggered a series of studies on the role of reactive oxygen species, glutathione, and its precursor cysteine in physiological and pathological processes. He discovered abnormally low cysteine and glutathione levels in human immunodeficiency virus-infected patients and the age-related decline in the postabsorptive plasma cysteine concentration, which is believed to cause age-related oxidative stress. He developed a theoretical concept of the mechanism of aging and death, which is outlined in his books Avoiding the First Cause of Death and Challenging the Limits of the Human Lifespan.

  19. DR Experiments in the 60 years since the Bates paper

    NASA Astrophysics Data System (ADS)

    Johnsen, Rainer

    2011-07-01

    About 60 years have passed since David Bates in a 1950 Physical Review Letter to the Editor first clarified the dissociative recombination mechanism (DR) of molecular ions and provided the conceptual basis for the process that plays an important role in the ionospheres of Earth and other planets, the interstellar medium, and electrical discharges. His visionary (and characteristically "terse") thumbnail sketch of the DR mechanism only hinted at the subtleties that have kept atomic theorists and experimentalists busy for many years. In my talk, I will focus on experiments on N2+ recombination, beginning with plasma afterglows, and then move on to the "after"-afterglow period that is now dominated by the powerful storage-ring methods.

  20. Dr. Howard Jones, Jr. (1910-2015): In Memoriam

    PubMed Central

    Oehninger, S.; Kruger, T.F.

    2015-01-01

    We honor the life of Howard W. Jones, Jr., MD, 104, a pioneer and visionary in reproductive medicine, a dedicated mentor, internationally renowned gynecological surgeon, and the father of in vitro fertilization IVF) in the United States. Dr. Jones founded the Jones Institute for Reproductive Medicine, in Norfolk, Virginia, at Eastern Virginia Medical School, in 1983. Today, IVF has grown exponentially not only in its direct application but also in the development of newer techniques would have been unimaginable a couple of decades ago. Throughout the years Dr. Howard has been a teacher and a mentor to many around the world. To us he also was a friend, a supporter at the time of difficult decisions, someone who would inspire hope, ignite the imagination, and instill a love of learning and untangling some of the complexities of the field, even of the human condition. His leadership, vision, knowledge, enthusiasm and inquisitive mind will be missed.

  1. 105-DR Large Sodium Fire Facility closure plan. Revision 1

    SciTech Connect

    Not Available

    1993-05-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, and activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide a means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950`s and is located in the 100-D Area of the Hanford Site. The building housed the 105-DR defense reactor, which was shut down in 1964. The LSFF was initially used only for engineering-scale alkali metal reaction studies. In addition, the Fusion Safety Support Studies program sponsored intermediate-size safety reaction tests in the LSFF with lithium and lithium lead compounds. The facility has also been used to store and treat alkali metal waste, therefore the LSFF is subject to the regulatory requirements for the storage and treatment of dangerous waste. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610. This closure plan presents a description of the facility, the history of waste managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected.

  2. Dr John Hall (1575-1635) and Shakespeare's medicine.

    PubMed

    Pearce, J M S

    2006-11-01

    The name of Dr John Hall is familiar to students of Shakespeare but less well known to medical biographers. He was born in 1575 and studied at Queen's College, Cambridge, but had no English medical degree. He was not a member of the Royal College of Physicians (founded in 1518). Around 1600, he established himself in Stratford. In June 1607 Hall married Susanna, Shakespeare's elder daughter. He died in 1635, an eminent Stratford physician and herbalist.

  3. 4. View of northerly DR 3 antenna looking north 35 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. View of northerly DR 3 antenna looking north 35 degrees west and showing radar scanner building no. 106 east face through antenna and partial view of satcom communication dome (attached to radar transmitter building 102) in left side of photograph. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  4. 8. View of DR 3 antenna showing lower front connector, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. View of DR 3 antenna showing lower front connector, third from left vertical member at first level above foundation level, showing small diameter turnbuckle stays, vertical member with flange connection, and various struts and connectors with antenna assembly in background. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  5. 21. Dr. Harrison E. Stroud poses in front of his ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Dr. Harrison E. Stroud poses in front of his newly completed building at the northeast corner of Central Avenue and the alley north of Washington Street in about 1900 or 1901. In 1901, the building seen here was enlarged by the construction of an addition of similar design immediately to the north (left). Virtually the entire west elevation of the initial building is depicted in this view. Credit ADLAPR. - Stroud Building, 31-33 North Central Avenue, Phoenix, Maricopa County, AZ

  6. Dr. John Stack and other NASA Langley Research Center Visitors

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Front Row, left to right: Mrs. Elsa Hoare and Major Philip L. Teed - staff members, Vickers-Armstrongs, Ltd., Weybridge, England: Dr. Barnes Wallis - Chief of Aeronautical Research, Vicers-Armstrong, Ltd., Weybridge, England. Back Row, left to right: Norman W. Boorer and Cecil W. Hayes - Staff members, Vickers-Armstrongs, Ltd., Weybridge, England; John R. Christie - Ministry of Supply, London, England; Philip A. Hufton - Chief Supt., Royal Aircraft Establishment, Bedford, England; Lindsey I. Turner, Jr. - Langley Research Center. Photographed November 13, 1958.

  7. ORAC-DR: A generic data reduction pipeline infrastructure

    NASA Astrophysics Data System (ADS)

    Jenness, Tim; Economou, Frossie

    2015-03-01

    ORAC-DR is a general purpose data reduction pipeline system designed to be instrument and observatory agnostic. The pipeline works with instruments as varied as infrared integral field units, imaging arrays and spectrographs, and sub-millimeter heterodyne arrays and continuum cameras. This paper describes the architecture of the pipeline system and the implementation of the core infrastructure. We finish by discussing the lessons learned since the initial deployment of the pipeline system in the late 1990s.

  8. Of Brain and Bone: The Unusual Case of Dr. A

    PubMed Central

    Narvid, J; Gorno-Tempini, ML; Slavotinek, A; DeArmond, SJ; Cha, YH; Miller, BL; Rankin, K.P

    2009-01-01

    Frontotemporal dementia (FTD) is a clinical syndrome characterized by progressive decline in social conduct and a focal pattern of frontal and temporal lobe damage. Its biological basis is still poorly understood but the focality of the brain degeneration provides a powerful model to study the cognitive and anatomical basis of social cognition. Here, we present Dr. A, a patient with a rare hereditary bone disease (hereditary multiple exostoses) and FTD (pathologically characterized as Pick’s disease), who presented with a profound behavioral disturbance characterized by acquired sociopathy. We conducted a detailed genetic, pathological, neuroimaging and cognitive study, including a battery of tests designed to investigate Dr. A’s abilities to understand emotional cues and to infer mental states and intentions to others (theory of mind). Dr. A’s genetic profile suggests the possibility that a mutation causing hereditary multiple exostoses, Ext2, may play a role in the pattern of neurodegeneration in frontotemporal dementia since knockout mice deficient in the Ext gene family member, Ext1, show severe CNS defects including loss of olfactory bulbs and abnormally small cerebral cortex. Dr. A showed significant impairment in emotion comprehension, second order theory of mind, attribution of intentions, and empathy despite preserved general cognitive abilities. Voxel-based morphometry on structural MRI images showed significant atrophy in the medial and right orbital frontal and anterior temporal regions with sparing of dorsolateral frontal cortex. This case demonstrates that social and emotional dysfunction in FTD can dissociate from preserved performance on classic executive functioning tasks. The specific pattern of anatomical damage shown by VBM emphasizes the importance of the network including the superior medial frontal gyrus as well as temporal polar areas, in regulation of social cognition and theory of mind. This case provides new evidence regarding the

  9. Dr. von Braun In Front of a Display of Missiles

    NASA Technical Reports Server (NTRS)

    1960-01-01

    In this photo, Director of the US Army Ballistic Missile Agency (ABMA) Development Operations Division, Dr. Wernher von Braun, is standing before a display of Army missiles celebrating ABMA's Fourth Open House. The missiles in the background include (left to right) a satellite on a Juno II shroud with a Nike Ajax pointing left in front of a Jupiter missile. The Lacrosse is in front of the Juno II. The Nike Hercules points skyward in front of the Juno II and the Redstone.

  10. Dr. John H. Hopps Jr. Research Scholars Program

    DTIC Science & Technology

    2014-10-20

    AFRL-OSR-VA-TR-2014-0262 John H. Hopps Jr. Research Scholars Program Rahmelle Thompson MOREHOUSE COLLEGE INC. Final Report 10/20/2014 DISTRIBUTION A...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) MOREHOUSE COLLEGE INC. 830 WESTVIEW DR SW ATLANTA, GA 30314-3773 US 8.  PERFORMING ORGANIZATION...Defense Research Scholars Program Morehouse College Hopps Defense Scholars

  11. Dr. Lytle Adams' incendiary "bat bomb" of World War II.

    PubMed

    Christen, Arden G; Christen, Joan A

    2004-11-01

    On December 7, 1941, a 60-year old dentist from Irwin, Pennsylvania, Dr. Lytle S. Adams, was driving home from a vacation at Carlsbad Caverns in New Mexico. Hours earlier, he had been gripped with amazement as he witnessed millions of bats exiting the caves of Carlsbad. Listening to his car radio on his return trip, he was shocked to hear that Japan had just attacked Pearl Harbor. Dr. Adams, outraged over this travesty, began to mentally construct a plan for U.S. retaliation. As his thoughts returned to the countless bats that had awed him, he formed a tentative plan: millions of these small, flying mammals could be connected to tiny, time-fused incendiary bombs, and then released to land on the flimsily constructed structures which dotted the cities of Japan. Within a few minutes, the bombs would explode and enflame the entire urban areas. He postulated that these immeasurable numbers of fires, spreading their devastation over such vast areas within Japanese cities would result in the enemy's speedy surrender. This article documents the futile efforts of Dr. Adams, his team and the U.S. government to develop and employ an effective, incendiary bat bomb. The recently developed atom bomb, a far more deadly weapon was used in its place.

  12. A famous Turkish dermatologist, Dr. Hulusi Behçet.

    PubMed

    UStün, Cagatay

    2002-01-01

    Dr. Hulusi Behçet (1889-1948) is a famous Turkish dermatologist. He was born in Istanbul on February 20, 1889. His father was Ahmet Behçet and his mother Ayqse Behçet was also Ahmet's cousin. After the Turkish Republic was established and the "Family Name Law" was accepted, his father Ahmet Behçet, who was among the friends of Mustafa Kemal Atatürk, the founder of Turkish Republic, received private permission to use his father's name Behçet. Dr. Hulusi Behçet pursued his education at Gülhane Military Medical Academy. After he had become a medical doctor, he specialized in dermatology and venereal disease at Gülhane Military Medical Academy and he completed his specialization in 1914. His first observations on Behçet's Disease started with a patient he met between 1924-1925. Dr. Behçet followed the symptoms of three patients whom he had had for years, then he decided that they were the symptoms of a new disease (1936). He published these cases in the Archives of Dermatology and Veneral Disease. He died from a sudden heart attack on March 8, 1948. Today, this disease is universally called Behçet's Disease in medical literature.

  13. Reminiscence of Dr. Emanuel Luxardo (1848-1905) and the family of Miho Klaić (1829-1896).

    PubMed

    Marinovic, Ivo

    2008-01-01

    This article is a reminiscence of four distinctive public figures who were related by family and who played key roles in the development of public health in Dalmatia in the second half of the 19th and the beginning of the 20th century. Dr Emanuel Luxardo (1848-1905) was a prominent physician and an able manager of the Dubrovnik and Zadar hospitals. In spite of his Italian origin, he championed the Croatian national reformation in Dalmatia. His father-in-law Miho Klaić (1829- 1896), as one of the most prominent Dalmatian politicians and champions of the national reformation movement, greatly contributed to the building of new hospitals in Zadar (1882), Sibenik (1883), and Dubrovnik (1888). The older of his two sons, Petar (1862-1910) was a lawyer and very active in the Dalmatian parliament, while the younger son Ljubo (1871-?) was a successful surgeon in Zadar and Split.

  14. Dr. Wernher Von Braun leads a tour of the S-IC checkout area.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Eberhard Rees, Charles Schultze, James Webb, Elmer Staats, Comptroller General of the United States, and Dr. Wernher Von Braun tour the S-IC checkout area in the Marshall Space Flight Center quality lab.

  15. Diffusely adherent Escherichia coli strains expressing Afa/Dr adhesins (Afa/Dr DAEC): hitherto unrecognized pathogens.

    PubMed

    Le Bouguénec, Chantal; Servin, Alain L

    2006-03-01

    Diffusely adherent Escherichia coli (DAEC) strains are currently considered to constitute a putative sixth group of diarrheagenic E. coli. However, on the basis of their diffuse adherence to HEp-2 and HeLa cells, the detection of afa/dra/daa-related operons encoding this adherence phenotype, and the mobilization of decay-accelerating factor, both commensal and pathogenic strains can be classified as Afa/Dr DAEC isolates. Furthermore, strains associated with diarrheal diseases and strains causing extra-intestinal infections can also be identified as Afa/Dr DAEC strains. Although several cell signaling events that occur after epithelial cells have been infected by Afa/Dr DAEC have been reported, the pathophysiological processes that allow intestinal and extra-intestinal infections to develop are not fully understood. This review focuses on the genetic organization of the afa/dra/daa-related operons and on the virulence factors that trigger cellular responses, some of which are deleterious for the host cells. Finally, this review suggests future lines of research that could help to elucidate these questions.

  16. Enhancing Price Response Programs through Auto-DR: California's 2007 Implementation Experience

    SciTech Connect

    Kiliccote, Sila; Wikler, Greg; Chiu, Albert; Piette, Mary Ann; Kiliccote, Sila; Hennage, Dan; Thomas, Chuck

    2007-12-18

    This paper describes automated demand response (Auto-DR) activities, an innovative effort in California to ensure that DR programs produce effective and sustainable impacts. Through the application of automation and communication technologies coupled with well-designed incentives and DR programs such as Critical Peak Pricing (CPP) and Demand Bidding (DBP), Auto-DR is opening up the opportunity for many different types of buildings to effectively participate in DR programs. We present the results of Auto-DR implementation efforts by the three California investor-owned utilities for the Summer of 2007. The presentation emphasizes Pacific Gas and Electric Company's (PG&E) Auto-DR efforts, which represents the largest in the state. PG&E's goal was to recruit, install, test and operate 15 megawatts of Auto-DR system capability. We describe the unique delivery approaches, including optimizing the utility incentive structures designed to foster an Auto-DR service provider community. We also show how PG&E's Critical Peak Pricing (CPP) and Demand Bidding (DBP) options were called and executed under the automation platform. Finally, we show the results of the Auto-DR systems installed and operational during 2007, which surpassed PG&E's Auto-DR goals. Auto-DR is being implemented by a multi-disciplinary team including the California Investor Owned Utilities (IOUs), energy consultants, energy management control system vendors, the Lawrence Berkeley National Laboratory (LBNL), and the California Energy Commission (CEC).

  17. Dr. Wernher Von Braun greeting dignitaries at the Redstone Arsenal airfield.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. George E. Mueller, center, associate administrator for manned space flight, is flanked by Dr. Wernher Von Braun, left, and Dr. Eberhard Rees at the Redstone Arsenal airstrip. the associate adminstrator was making his annual staff visit to the Marshall Space Flight Center.

  18. The extent of HLA-DR expression on HLA-DR(+) Tregs allows the identification of patients with clinically relevant borderline rejection.

    PubMed

    Schaier, Matthias; Seissler, Nicole; Becker, Luis Eduardo; Schaefer, Sebastian Markus; Schmitt, Edgar; Meuer, Stefan; Hug, Friederike; Sommerer, Claudia; Waldherr, Rüdiger; Zeier, Martin; Steinborn, Andrea

    2013-03-01

    Regulatory T cells (Tregs) were shown to be involved into the pathogenesis of acute rejection after transplantation. The suppressive activity of the total regulatory T cell pool depends on its percentage of highly suppressive HLA-DR(+) -Treg cells. Therefore, both the suppressive activity of the total Treg pool and the extent of HLA-DR expression of HLA-DR(+) -Tregs (MFI HLA-DR) were estimated in non transplanted volunteers, patients with end-stage renal failure (ESRF), healthy renal transplant patients with suspicion on rejection, due to sole histological Bord-R or sole acute renal failure (ARF), and patients with clinically relevant borderline rejection (Bord-R and ARF). Compared to patients with only Bord-R or only ARF, the suppressive activity of the total Treg cell pool was exclusively reduced in patients with clinically relevant Bord-R. In parallel, the HLA-DR MFI of the DR(+) -Treg subset was significantly decreased in these patients, due to a significantly lower proportion of DR(high+) -Tregs, which were shown to have the highest suppressive capacity within the total Treg pool. Our findings clearly demonstrate that the determination of the HLA-DR MFI of the HLA-DR(+) -Treg subset allows a highly sensitive, specific and non-invasive discrimination between patients with clinically relevant Bord-R (Bord and ARF) and patients with subclinical rejection or other causes of transplant failure.

  19. Human immune responsiveness to Lolium perenne pollen allergen Lol p III (rye III) is associated with HLA-DR3 and DR5.

    PubMed

    Ansari, A A; Freidhoff, L R; Meyers, D A; Bias, W B; Marsh, D G

    1989-05-01

    A well-characterized allergen of Lolium perenne (perennial rye grass) pollen, Lol p III, has been used as a model antigen to study the genetic control of the human immune response. Associations between HLA type and IgE or IgG antibody (Ab) responsiveness to Lol p III were studied in two groups of skin-test-positive Caucasoid adults (N = 135 and 67). We found by nonparametric and parametric analyses that immune responsiveness to Lol p III was significantly associated with HLA-DR3 and DR5. No association was found between any DQ type and immune responsiveness to Lol p III. Geometric mean IgE or IgG Ab levels to Lol p III were not different between B8+, DR3+ subjects and B8-, DR3+ subjects, showing that HLA-B8 had no influence on the association. Lol p III IgG Ab data obtained on subjects after grass antigen immunotherapy showed that 100% of DR3 subjects and 100% of DR5 subjects were Ab+. A comparison of all the available protein sequences of DRB gene products showed that the first hypervariable region of DR3 and DR5 (and DRw6), and no other region, contains the sequence Glu9-Tyr-Ser-Thr-Ser13. Our observations are consistent with the possibility that immune responsiveness to the allergen Lol p III is associated with this amino acid sequence in the first hypervariable region of the DR beta 1 polypeptide chain.

  20. Historical vignette: Dr Charles Robson; pioneer Canadian pediatric anesthetist.

    PubMed

    Steward, David J

    2012-03-01

    Charles Robson (Figure 1) was born in New Westminster, British Columbia (now a suburb of Vancouver), in 1884 and graduated in medicine from McGill University in Montreal in 1913. Having interned and with some anesthesia training at the Royal Victoria Hospital in Montreal, he was sent overseas to work in a Canadian Army Hospital where he founded a school to train military anesthetists. Returning to Canada in 1919, he joined the staff of the Hospital for Sick Children in Toronto as chief anesthetist, a position he held until 1951 (1). During most of this time, he was the sole full-time anesthetist at the hospital; administration of anesthesia at this hospital was not limited to staff anesthetists until 1950 (1).

  1. Enhancing Anti-Breast Cancer Immunity by Blocking Death Receptor DR5

    DTIC Science & Technology

    2009-09-01

    encoding full length human DR5, phDR5∆ encoding human DR5 with a premature termination signal in the death domain (aa.1-338) and phDR5ECTM encoding the...by Blocking Death Receptor DR5 PRINCIPAL INVESTIGATOR: Wei-Zen Wei, Ph.D. CONTRACTING ORGANIZATION: Wayne State University...Annual 3. DATES COVERED 1 Sep 2008 – 31 Aug 2009 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Enhancing Anti-Breast Cancer Immunity by Blocking Death

  2. Dr Robert Proust: a gynaecologist's contribution to world literature.

    PubMed

    de Costa, Caroline

    2013-09-01

    Dr Robert Proust, though overshadowed in history by his more famous brother, the novelist Marcel Proust, was an eminent and innovative French surgeon who achieved recognition largely as a gynaecologist, but also was an accomplished urologist and general surgeon. He was the author of a textbook, The surgery of the female genital tract, that was very successful in his lifetime and ran to six editions. He was always very supportive of his brother's writing, and after Marcel's premature death Robert edited and arranged for publication of the final three volumes of his novel À la recherche du temps perdu, which has been called the greatest novel of the twentieth century.

  3. Dr. Christopher Kraft looks over packaged 'parasol' in bldg 10

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Dr. Christopher C. Kraft J. (left), JSC Director, and George A Post, JSC Crew Systems Division, look over the packaged 'parasol' during fabrication and checkout of the umbrella-like mechanical device in the Technical Services shop in bldg 10 at JSC. The 'parasol' is designed to fit into the T027 experiment photometer canister. The canopy portion of the 'parasol' measures 24 feet by 22 feet. The 'parasol' is one of several sunscreen possibilities being considered for use in shading the overheated Skylab 1 Orbital Workshop.

  4. STS-72 Mission Specialist Dr. Daniel T. Barry suits up

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Looking elated at the prospect of his upcoming spaceflight, STS- 72 Mission Specialist Dr. Daniel T. Barry dons his launch/entry suit in the Operations and Checkout Building with assistance from a suit technician. The trip into space will be the first for Barry, a medical doctor who also has a Ph.D. in electrical engineering. He and five fellow crew members will soon depart for Launch Pad 39, where the Space Shuttle Endeavour is undergoing final preparations for liftoff during an approximately 49-minute window opening at about 4:18 am EST, January 11.

  5. STS-71 Payload Commander Dr. Ellen S. Baker suits up

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-71 Payload Commander Dr. Ellen S. Baker is assisted by a suit technician as she dons her launch/entry suit in the Operations and Checkout Building. Her third spaceflight will be an historic one for Baker, a medical doctor, as she oversees the series of scientific investigations that will be conducted during the first docking of the U.S. Space Shuttle to the Russian Space Station Mir. Baker and six fellow crew members -- four Americans and two Russian cosmonauts -- will shortly depart for Launch Pad 39A, where the Space Shuttle Atlantis awaits liftoff during a 10- minute launch window opening at 3:32 p.m. EDT.

  6. Progress in inflammatory neuropathy -the legacy of Dr Jack Griffin.

    PubMed

    Feldman, Eva L; Hughes, Richard A C; Willison, Hugh J

    2015-11-01

    The past quarter of a century has brought incredible advances in our understanding of inflammatory neuropathies, and the insights into Guillain-Barré syndrome (GBS) began in the 1990s with the seminal work of Dr Jack Griffin and his colleagues. In this essay, we provide a tribute to Jack, and review the recent progress in a field that he termed his personal favourite. In particular, we discuss the new developments in our understanding and diagnosis of inflammatory neuropathies, the recent emergence of the node of Ranvier and the paranode as sites of intensive investigation, and the mechanistic evidence that is providing a platform for therapeutic development studies.

  7. 89. View of DR 2 antenna (structure no. 736) at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    89. View of DR 2 antenna (structure no. 736) at 65 percent completion showing erection process. Antenna system designed and factory construction by D.S. Kennedy & Company., Comasset, MA, 1958. Note scanner radar building in background. Official photograph BMEWS Project by unknown photographer, 11 July, 1960, Photographic Services, Riverton, NJ, BMEWS, clear as negative no. A-824. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  8. A conversation with Dr Michael Fordham. Interview by James Astor.

    PubMed

    Fordham, Michael

    2005-02-01

    In this interview in Dr Fordham's 83rd year he describes how he started to work with children, and how Mrs Jung was supportive. He talks about the initial suspicion this interest generated in the wider Jungian community. He refers to his acceptance of and interest in the psychotic elements in child analysis and his transference-based approach to working with these elements. He reflects on his own birth, his work with evacuee children in hostels during the war years and the politics of supervision. He describes the core Jungian concepts which underpinned his work and the theoretical differences from the Kleinian and Anna Freudian positions.

  9. The portrait of Dr Edward Harrison MD (1766-1838).

    PubMed

    Bovine, Gary

    2010-08-01

    The portrait of the London and Horncastle Physician Edward Harrison, painted and displayed in 1823, was editorially criticized by one of the medical journals of the time. After Harrison died the portrait remained in the family estate until 1938, after which it was presented to the National Gallery of Ireland. The image of Dr Harrison had never been displayed in any of his medical writings, nor in any other medical historical works, until 2008. This paper provides some history of the criticism of the portrait, similar to the historical vignette of the portraiture of William Harvey and outlines the detective work to track down the location of the portrait.

  10. Mediastinal pathology and the contributions of Dr. Juan Rosai.

    PubMed

    Wick, Mark R

    2016-09-01

    Dr. Juan Rosai is one of the most prolific contributors to the literature on mediastinal pathology, and he has added steadily to that body of work over a 50-year period. Rosai has written several landmark articles in this topical area, including articles on thymic epithelial lesions, mediastinal neuroendocrine tumors, mediastinal lymphoma and other hematopoietic lesions, thymolipoma, thymoliposarcoma, mediastinal solitary fibrous tumor, intrathymic langerhans-cell histiocytosis, mediastinal germ cell neoplasms, and multilocular thymic cyst. This review recounts his role as one of the principal figures in the surgical pathology of mediastinal diseases.

  11. [The SS dentist Dr. Willy Frank. A biography].

    PubMed

    Huber, Barbara

    2009-01-01

    In his role as leading SS dentist in the concentration camp Auschwitz-Birkenau Dr. Willy Frank was involved in the worst crimes of World War II: In the early summer of 1944 the so called "Hungarian Action" commenced. It planned the extermination of around 450 000 Hungarian Jews within only a few months. Some twenty years later he was sentenced during the Frankfurt Auschwitz Trials to seven years of imprisonment on grounds of his participation in the selection and gassing of the Jews. Before that he had been able to resume his professional worksince 1947 unchecked.

  12. [100 years of Dr. Ehrlich's magic bullet (1909-2009)].

    PubMed

    García-Sánchez, José Elías; García, Enrique; Merino, María Lucila

    2010-10-01

    The aim of this article is to pay tribute to Paul Ehrlich and his contributions to science, in particular those related to antimicrobial therapy, at the end of a prodigious decade of celebrations to fête his person and work. The year 2009 marks the centenary of the discovery of the experimental anti-syphilitic activity of Salvarsan and the first clinical studies showing its efficacy against syphilis. This homage is conveyed through the presentation of bibliographic data, mention of his most important scientific achievements based on his original publications, and by analyzing the film Dr. Ehrlich's Magic Bullet (1940) by William Dieterle.

  13. Dr. von Braun on the Mobility Test Article (MTA)

    NASA Technical Reports Server (NTRS)

    1966-01-01

    In this June 1966 photograph, Marshall Space Flight Center Director Dr. Wernher von Braun test-drives the Mobility Test Article (MTA), a developmental vehicle built by the Bendix Corporation to test lunar mobility vehicle concepts. The data provided by the MTA helped in designing the Lunar Roving Vehicle (LRV), developed under the direction of the MSFC. The LRV was designed to allow Apollo astronauts a greater range of mobility during lunar exploration missions. The LRVs were deployed during the last three Apollo missions; Apollo 15, Apollo 16, and Apollo 17.

  14. Dr. von Braun Driving the Mobility Test Article

    NASA Technical Reports Server (NTRS)

    1966-01-01

    In this June, 1966 photograph, Marshall Space Flight Center Director, Dr. Wernher von Braun test drives the Mobility Test Article (MTA), a developmental vehicle built by the Bendix Corporation to test lunar mobility concepts. The data provided by the MTA helped in designing the Lunar Roving Vehicle (LRV), developed under the direction of the Marshall Space Flight Center. The LRV was designed to allow Apollo astronauts a greater range during lunar exploration missions and served its purpose during the last three Apollo lunar missions in 1971 and 1972.

  15. ORAC-DR: Pipelining With Other People's Code

    NASA Astrophysics Data System (ADS)

    Economou, Frossie; Bridger, Alan; Wright, Gillian S.; Jenness, Tim; Currie, Malcolm J.; Adamson, Andy

    As part of the UKIRT ORAC project, we have developed a pipeline (orac-dr) for driving on-line data reduction using existing astronomical packages as algorithm engines and display tools. The design is modular and extensible on several levels, allowing it to be easily adapted to a wide variety of instruments. Here we briefly review the design, discuss the robustness and speed of execution issues inherent in such pipelines, and address what constitutes a desirable (in terms of ``buy-in'' effort) engine or tool.

  16. Dr. von Braun and Army Ballistics Missile Agency (ABMA) Group

    NASA Technical Reports Server (NTRS)

    1959-01-01

    This photograph of Dr. von Braun, shown here to the left of General Bruce Medaris, was taken in the fall of 1959, immediately prior to Medaris' retirement from the Army. At the time, von Braun and his associates worked for the Army Ballistics Missile Agency in Huntsville, Alabama. Those in the photograph have been identified as Ernst Stuhlinger, Frederick von Saurma, Fritz Mueller, Hermarn Weidner, E.W. Neubert (partially hidden), W.A. Mrazek, Karl Heimburg, Arthur Rudolph, Otto Hoberg, von Braun, Oswald Lange, Medaris, Helmut Hoelzer, Hans Maus, E.D. Geissler, Hans Heuter, and George Constan.

  17. My friend Dr Knox: a pupil writes about the anatomist.

    PubMed

    Johnson, A

    2005-12-01

    Thomas Giordani Wright, a medical apprentice in Newcastle upon Tyne, attended Dr Robert Knox's anatomy classes in Edinburgh between November 1825 and April 1826, only two years before Burke and Hare began murdering people and selling the bodies of their victims to Knox's anatomy school. In March 1829, soon after the crimes came to light and Burke had been found guilty of murder and executed, Wright commented on the case in his diary, describing the practices in the dissection rooms and giving his views on Robert Knox, the teacher who had become his friend.

  18. DR Resources for Energy and Ancillary Services in the West (Presentation)

    SciTech Connect

    Hummon, M.; Kiliccote, S.

    2014-04-01

    Demand response (DR) resources present a potentially important source of grid flexibility however, DR in grid models is limited by data availability and modeling complexity. This presentation focuses on the co-optimization of DR resources to provide energy and ancillary services in a production cost model of the Colorado "test system". We assume each DR resource can provide energy services by either shedding load or shifting its use between different times, as well as operating reserves: frequency regulation, contingency reserve, and flexibility (or ramping) reserve. There are significant variations in the availabilities of different types of DR resources, which affect both the operational savings as well as the revenue for each DR resource. The results presented include the system-wide avoided fuel and generator start-up costs as well as the composite revenue for each DR resource by energy and operating reserves.

  19. The Chicago Board of Education Desegregation Policies and Practices [1975-1985]: A Historical Examination of the Administrations of Superintendents Dr. Joseph P. Hannon and Dr. Ruth Love

    ERIC Educational Resources Information Center

    James, Michael

    2009-01-01

    The purpose of this study will be to examine the policies and practices of two distinguished superintendents of the Chicago Public Schools: Dr. Joseph P. Hannon and the first African American female Superintendent Dr. Ruth Love. Hannon's four year administration extended from 1975 through 1979. Love's administration encompassed the years 1980…

  20. Clinical and molecular studies in full trisomy 22: Further delineation of the phenotype and review of the literature. Reply to Dr. Robinson and Dr. Kalousek

    SciTech Connect

    Bacino, C.A.; Graham, J.M. Jr.

    1996-03-01

    This {open_quotes}Letter to the Editor{close_quotes} responds to the comments by Dr. Robinson and Dr. Kalousek regarding the implications of meiotic versus somatic chromosomal aberrations. The survival time of the patient may depend on the detection of mosicism; the discussion of the existence of full trisomy 22 remains controversial. 2 refs.

  1. Census of Blue Stars in SDSS DR8

    NASA Astrophysics Data System (ADS)

    Scibelli, Samantha; Newberg, Heidi Jo; Carlin, Jeffrey L.; Yanny, Brian

    2014-12-01

    We present a census of the 12,060 spectra of blue objects ((g - r)0 < -0.25) in the Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8). As part of the data release, all of the spectra were cross-correlated with 48 template spectra of stars, galaxies, and QSOs to determine the best match. We compared the blue spectra by eye to the templates assigned in SDSS DR8. 10,856 of the objects matched their assigned template, 170 could not be classified due to low signal-to-noise ratio, and 1034 were given new classifications. We identify 7458 DA white dwarfs, 1145 DB white dwarfs, 273 rarer white dwarfs (including carbon, DZ, DQ, and magnetic), 294 subdwarf O stars, 648 subdwarf B stars, 679 blue horizontal branch stars, 1026 blue stragglers, 13 cataclysmic variables, 129 white dwarf-M dwarf binaries, 36 objects with spectra similar to DO white dwarfs, 179, quasi-stellar objects (QSOs), and 10 galaxies. We provide two tables of these objects, sample spectra that match the templates, figures showing all of the spectra that were grouped by eye, and diagnostic plots that show the positions, colors, apparent magnitudes, proper motions, etc., for each classification. Future surveys will be able to use templates similar to stars in each of the classes we identify to automatically classify blue stars, including rare types.

  2. CENSUS OF BLUE STARS IN SDSS DR8

    SciTech Connect

    Scibelli, Samantha; Newberg, Heidi Jo; Carlin, Jeffrey L.; Yanny, Brian

    2015-01-01

    We present a census of the 12,060 spectra of blue objects ((g – r){sub 0} < –0.25) in the Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8). As part of the data release, all of the spectra were cross-correlated with 48 template spectra of stars, galaxies, and QSOs to determine the best match. We compared the blue spectra by eye to the templates assigned in SDSS DR8. 10,856 of the objects matched their assigned template, 170 could not be classified due to low signal-to-noise ratio, and 1034 were given new classifications. We identify 7458 DA white dwarfs, 1145 DB white dwarfs, 273 rarer white dwarfs (including carbon, DZ, DQ, and magnetic), 294 subdwarf O stars, 648 subdwarf B stars, 679 blue horizontal branch stars, 1026 blue stragglers, 13 cataclysmic variables, 129 white dwarf-M dwarf binaries, 36 objects with spectra similar to DO white dwarfs, 179, quasi-stellar objects (QSOs), and 10 galaxies. We provide two tables of these objects, sample spectra that match the templates, figures showing all of the spectra that were grouped by eye, and diagnostic plots that show the positions, colors, apparent magnitudes, proper motions, etc., for each classification. Future surveys will be able to use templates similar to stars in each of the classes we identify to automatically classify blue stars, including rare types.

  3. PREFACE: Eighth International Conference on Dissociative Recombination (DR2010)

    NASA Astrophysics Data System (ADS)

    Guberman, Steven L.; Orel, Ann E.

    2011-07-01

    In dissociative recombination (DR), a molecular ion captures an electron and falls apart. One might initially conclude that this process is relatively simple. However, a review of the DR literature over the past 60 years, since the pioneering papers of Sir David Bates [1], shows that the study of DR has proved to be highly challenging for both theorists and experimentalists. Both this challenge and the ubiquitous importance of the process have made its study rewarding, endlessly interesting, and full of surprises. DR is fundamentally the interaction of an electronic continuum with a vibrational continuum often connected by quasibound intermediate states. Autoionization in the first continuum competes with dissociation in the second. DR occurs at the total energy of an ion plus a free electron and is in the same region as vibrationally excited Rydberg states and other neutral superexcited states. All these states interact with each other prior to dissociation, forming a complex that controls the quantum yields of products. The complexity of the process has required both innovation and ingenuity on the part of both theorists and experimentalists. Over the years, it has become apparent that in order to compare theoretical and experimental results, the experiments must identify the electronic, vibrational and for low mass ions, the rotational state. The traditional disagreement between theoretical and experimental results has been due, in part, to the sensitivity of DR cross sections and rate constants to the state of the recombining ion. Great progress has been made in recent years in both flowing afterglow and storage ring experiments aimed at reducing this uncertainty. The latest advances and insights in theory and experiment were the topics of the Eighth International Conference on Dissociative Recombination held at the Granlibakken Lodge at Lake, Tahoe, California, 16-20 August 2010. The conference was part of a series of conferences on DR that started at Chateau

  4. M-giant star candidates identified in LAMOST DR 1

    NASA Astrophysics Data System (ADS)

    Zhong, Jing; Lépine, Sébastien; Li, Jing; Chen, Li; Hou, Jin-Liang; Yang, Ming; Li, Guang-Wei; Zhang, Yong; Hou, Yong-Hui

    2015-08-01

    We perform a discrimination procedure with the spectral index diagram of TiO5 and CaH2+CaH3 to separate M giants from M dwarfs. Using the M giant spectra identified from LAMOST DR1 with high signal-to-noise ratio, we have successfully assembled a set of M giant templates, which show more reliable spectral features. Combining with the M dwarf/subdwarf templates in Zhong et al., we present an extended library of M-type templates which includes not only M dwarfs with a well-defined temperature and metallicity grid but also M giants with subtypes from M0 to M6. Then, the template-fitting algorithm is used to automatically identify and classify M giant stars from LAMOST DR1. The resulting catalog of M giant stars is cross-matched with 2MASS JHKs and WISE W1/W2 infrared photometry. In addition, we calculated the heliocentric radial velocity of all M giant stars by using the cross-correlation method with the template spectrum in a zero-velocity rest frame. Using the relationship between the absolute infrared magnitude MJ and our classified spectroscopic subtype, we derived the spectroscopic distance of M giants with uncertainties of about 40%. A catalog of 8639 M giants is provided. As an additional result of this analysis, we also present a catalog of 101 690 M dwarfs/subdwarfs which are processed by our classification pipeline.

  5. Ibuprofen enhances TRAIL-induced apoptosis through DR5 upregulation.

    PubMed

    Todo, Momoko; Horinaka, Mano; Tomosugi, Mitsuhiro; Tanaka, Ryoichi; Ikawa, Haruna; Sowa, Yoshihiro; Ishikawa, Hideki; Fujiwara, Hitoshi; Otsuji, Eigo; Sakai, Toshiyuki

    2013-11-01

    Numerous human chemoprevention studies have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) possess chemopreventive effects against a variety of malignant tumors. However, there have been many clinical studies on aspirin, but not ibuprofen, even though ibuprofen is one of the most clinically and safely used NSAIDs showing potent anti-inflammatory effects. Moreover, we reported that many chemopreventive agents enhance the apoptosis-inducing effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is known to be crucial for cancer prevention. We, therefore, investigated whether ibuprofen enhances the cytocidal effect of TRAIL and found that ibuprofen markedly stimulated the apoptosis-inducing efficacy of TRAIL against human colon cancer HCT116 cells. As detected by western blot analysis and real-time RT-PCR, ibuprofen upregulated the expression of death receptor 5 (DR5), a TRAIL receptor. TRAIL-induced apoptosis enhanced by ibuprofen was effectively decreased by a caspase inhibitor and dominant-negative DR5. Noteworthy, co-treatment of ibuprofen with TRAIL did not enhance apoptosis in normal peripheral blood mononuclear cells (PBMCs). These results demonstrated that ibuprofen and TRAIL synergistically induced apoptosis in human colon cancer HCT116 cells but not in normal PBMCs, raising the possibility that ibuprofen may be promising as a safe chemopreventive agent against colon cancer.

  6. Pathogenesis of human diffusely adhering Escherichia coli expressing Afa/Dr adhesins (Afa/Dr DAEC): current insights and future challenges.

    PubMed

    Servin, Alain L

    2014-10-01

    The pathogenicity and clinical pertinence of diffusely adhering Escherichia coli expressing the Afa/Dr adhesins (Afa/Dr DAEC) in urinary tract infections (UTIs) and pregnancy complications are well established. In contrast, the implication of intestinal Afa/Dr DAEC in diarrhea is still under debate. These strains are age dependently involved in diarrhea in children, are apparently not involved in diarrhea in adults, and can also be asymptomatic intestinal microbiota strains in children and adult. This comprehensive review analyzes the epidemiology and diagnosis and highlights recent progress which has improved the understanding of Afa/Dr DAEC pathogenesis. Here, I summarize the roles of Afa/Dr DAEC virulence factors, including Afa/Dr adhesins, flagella, Sat toxin, and pks island products, in the development of specific mechanisms of pathogenicity. In intestinal epithelial polarized cells, the Afa/Dr adhesins trigger cell membrane receptor clustering and activation of the linked cell signaling pathways, promote structural and functional cell lesions and injuries in intestinal barrier, induce proinflammatory responses, create angiogenesis, instigate epithelial-mesenchymal transition-like events, and lead to pks-dependent DNA damage. UTI-associated Afa/Dr DAEC strains, following adhesin-membrane receptor cell interactions and activation of associated lipid raft-dependent cell signaling pathways, internalize in a microtubule-dependent manner within urinary tract epithelial cells, develop a particular intracellular lifestyle, and trigger a toxin-dependent cell detachment. In response to Afa/Dr DAEC infection, the host epithelial cells generate antibacterial defense responses. Finally, I discuss a hypothetical role of intestinal Afa/Dr DAEC strains that can act as "silent pathogens" with the capacity to emerge as "pathobionts" for the development of inflammatory bowel disease and intestinal carcinogenesis.

  7. Pathogenesis of Human Diffusely Adhering Escherichia coli Expressing Afa/Dr Adhesins (Afa/Dr DAEC): Current Insights and Future Challenges

    PubMed Central

    2014-01-01

    SUMMARY The pathogenicity and clinical pertinence of diffusely adhering Escherichia coli expressing the Afa/Dr adhesins (Afa/Dr DAEC) in urinary tract infections (UTIs) and pregnancy complications are well established. In contrast, the implication of intestinal Afa/Dr DAEC in diarrhea is still under debate. These strains are age dependently involved in diarrhea in children, are apparently not involved in diarrhea in adults, and can also be asymptomatic intestinal microbiota strains in children and adult. This comprehensive review analyzes the epidemiology and diagnosis and highlights recent progress which has improved the understanding of Afa/Dr DAEC pathogenesis. Here, I summarize the roles of Afa/Dr DAEC virulence factors, including Afa/Dr adhesins, flagella, Sat toxin, and pks island products, in the development of specific mechanisms of pathogenicity. In intestinal epithelial polarized cells, the Afa/Dr adhesins trigger cell membrane receptor clustering and activation of the linked cell signaling pathways, promote structural and functional cell lesions and injuries in intestinal barrier, induce proinflammatory responses, create angiogenesis, instigate epithelial-mesenchymal transition-like events, and lead to pks-dependent DNA damage. UTI-associated Afa/Dr DAEC strains, following adhesin-membrane receptor cell interactions and activation of associated lipid raft-dependent cell signaling pathways, internalize in a microtubule-dependent manner within urinary tract epithelial cells, develop a particular intracellular lifestyle, and trigger a toxin-dependent cell detachment. In response to Afa/Dr DAEC infection, the host epithelial cells generate antibacterial defense responses. Finally, I discuss a hypothetical role of intestinal Afa/Dr DAEC strains that can act as “silent pathogens” with the capacity to emerge as “pathobionts” for the development of inflammatory bowel disease and intestinal carcinogenesis. PMID:25278576

  8. Amplification of a single-locus variable-number direct repeats with restriction fragment length polymorphism (DR-PCR/RFLP) for genetic typing of Acinetobacter baumannii strains.

    PubMed

    Nowak-Zaleska, Alicja; Krawczyk, Beata; Kotłowski, Roman; Mikucka, Agnieszka; Gospodarek, Eugenia

    2008-01-01

    In search of an effective DNA typing technique for Acinetobacter baumannii strains for hospital epidemiology use, the performance and convenience of a new target sequence was evaluated. Using known genomic sequences of Acinetobacter baumannii strains AR 319754 and ATCC 17978, we developed single-locus variable-number direct-repeat analysis using polymerase chain reaction-restriction fragment length polymorphism (DR-PCR/RFLP) method. A total of 90 Acinetobacter baumannii strains isolated from patients of the Clinical Hospital in Bydgoszcz, Poland, were examined. Initially, all strains were typed using macrorestriction analysis of the chromosomal DNA by pulsed-field gel electrophoresis (REA-PFGE). Digestion of the chromosomal DNA with the ApaI endonuclease and separation of the fragments by PFGE revealed 21 unique types. Application of DR-PCR/RFLP resulted in recognition of 12 clusters. The results showed that the DR-PCR/RFLP method is less discriminatory than REA-PFGE, however, the novel genotyping method can be used as an alternative technique for generating DNA profiles in epidemiological studies of intra-species genetic relatedness of Acinetobacter baumannii strains.

  9. Diverse locations of amino acids in HLA-DR beta chains involved in polymorphic antibody binding epitopes on DR(alpha, beta 1*0101), DR(alpha, beta 1*1101), and DR(alpha,beta 3*0202) molecules.

    PubMed

    Fu, X T; Klohe, E; Alber, C; Yu, W Y; Ferrara, G B; Pistillo, M P; Ballas, M; Karr, R W

    1992-03-01

    In a previous study, we used transfectants expressing hybrid HLA-DR(beta 1*0403)/DR(beta 1*0701) chains to map sequences involved in polymorphic antibody binding epitopes on DR(alpha, beta 1*0403) or DR(alpha, beta 1*0701) molecules. Amino acids 1-40 of the beta 1 domain were found to make the major contributions to most of the antibody binding epitopes studied. To begin to localize sequences that contribute to polymorphic antibody epitopes on DR(alpha,beta 1*0101), DR(alpha,beta 1*1101) and DR(alpha,beta 3*0202) molecules, we used indirect immunofluorescence and flow cytometry to assess the binding of mAb to transfectants expressing hybrid DR(beta 1*0101)/DR(beta 1*1101) or DR(beta 1*1101)/DR(beta 3*0202) chains that divide the DR beta chain into three segments: amino acids 1-40, 41-97, and the beta 2 domain. The results indicate that amino acids 41-97 of the beta 1 domain on DR(beta 1*0101), DR(beta 1*1101), or DR(beta 3*0202) are critical in most of the epitopes, including those recognized by human antibodies MP4 and MP12, and mouse mAb GS88.2, I-LR1, 21r5, and 7.3.19.1, whereas amino acids 1-40 of DR(beta 1*1101) are critical in the epitope recognized by the MCS-7 mAb, and both segments 1-40 and 41-97 of DR(beta 1*1101) are important in the epitopes recognized by the I-LR2 and UL-52 mAbs. Based on these data and comparison of DR beta allelic protein sequences, the residues that may play critical roles in these antibody binding epitopes are predicted.

  10. [Story of three SS dentists during World War II: Pr Hugo Blaschke, Dr Hermann Pook and Dr Willy Frank].

    PubMed

    Riaud, Xavier

    2006-12-01

    This story of three SS dentists shows very clearly that the medical code of ethics, under a totalitarian regime, ends where ideology begins. Professor Hugo Blaschke provided dental care to the most eminent Nazi leaders, but he also was the senior SS dentist. He was in charge of dental care in the Waffen-SS, and therefore, he had responsibility for the stocks of dental gold collected from the mouths of those who died in the concentration camps, in order to make dentures for his soldiers. Dr Hermann Pook was the dentist in charge of all the other dentists practising in the concentration camps. He was responsible for gathering statistics on the dental care provided for prisoners in the camps. His instructions were very clear: "No conservation or restorative treatment. Only extractions, and with no anaesthesia!" He was also in charge of gathering the gold that was collected in the camps, for the financial department of the SS. Dr Willy Frank, an Auschwitz dentist, took part in the selection of some of the convoys for the gas chambers. His participation in the collection of gold from the mouths of the dead was also established. These three men were sentenced to prison for War Crimes and Crimes against Humanity.

  11. [DR. Hanka Weinberg-Heruti: the pediatrician from Merchavia--the first woman-doctor 'Kibbutznik' in the Kibbutz Ha'artzi].

    PubMed

    Shehory-Rubin, Zipora

    2015-07-01

    Dr. Hanka Weinberg-Heruti, a pediatrician at the Ha'Emek Hospital and a member of Kibbutz Merchavia is regarded in the history of medicine in Eretz Israel as the first female physician in the Kibbutz Ha'Artzi movement-Hashomer Hatsa'ir, and one of the founders of children's medicine in the country. Dr. Weinberg-Heruti was able to break the accepted norms of the period and prove "you could be both a hospital doctor and a loyal kibbutz member". This was far from simple for there was an iron rule in that kibbutz movement: "Every member must perform physical labour to build the kibbutz and to work in its framework. This principle is inviolable nor can one deviate from the norm". Dr. Weinberg-Heruti dared to break that rule and prove that a successful combination of both her purposes in life was possible. Thus, the aim of the article is twofold: to survey her unique position as hospital doctor and faithful 'kibbutznik', who dared to break the "holy" principle at the ideological roots of kibbutz life--that it was unthinkable for a member to refrain from physical labour. Secondly, to illuminate her medical career as pediatrician in Ha'Emek Hospital, and describe the innovations she introduced to the children's ward, survey her groundbreaking research, that examined the influence of the Beit Shean Valley climate on infant development. Her conclusions dramatically affected the treatment and upbringing of children in that climate, and were adopted not only in local kibbutzim but throughout the country.

  12. Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks.

    PubMed

    Bertram, Helge; Nerlich, Andreas; Omlor, Georg; Geiger, Florian; Zimmermann, Gerald; Fellenberg, Joerg

    2009-07-01

    Intervertebral disks degenerate far earlier than other musculoskeletal tissues and apoptosis has been suggested to have a vital function in promoting the degeneration process that is strongly associated with back pain. However, the molecular mediators of apoptosis in the intervertebral disk are poorly understood. Fas/FasL, TRAIL/DR4, TRAIL/DR5 and TNF-alpha/TNFR1 are ligand/receptor pairs of the tumor necrosis factor/nerve growth factor family, which are able to induce apoptosis by trimerization of the receptor by its corresponding ligand. We investigated which of these molecules are expressed in intervertebral disks and whether their expression correlates to disk degeneration. Intervertebral disks from 28 donors (age 12-70 years) suffering from scoliosis, vertebrae fracture or disk degeneration were scored histologically for degeneration and analyzed for gene expression of FasL/Fas, TRAIL/DR4, TNF-alpha/TNFR1 and caspase 8. Protein expression of FasL and TRAIL was assessed by immunohistology and apoptotic cell death was quantified by poly(ADP-ribose) polymerase (PARP) p85 staining. Isolated disk cells were analyzed by flow cytometry for Fas, FasL, TRAIL, DR4 and DR5 expression. Gene expression of TRAIL (P=0.002) and caspase 8 (P=0.027) significantly correlated with degeneration. TRAIL expression further correlated with cellularity (P=0.04), muccoid matrix changes (P=0.009) and tears and cleft formation (P=0.019). FasL and TRAIL expression was confirmed by immunohistology and PARP cleavage was significantly associated with degeneration (P=0.027). Flow cytometry on isolated disk cells revealed correlations between DR4 and degeneration (P=0.014), DR4/DR5 double-positive cells and degeneration (P=0.019), as well as DR5 and changes in tissue granularity (P=0.03). This is the first study that shows that intervertebral disk cells express TRAIL, DR4 and DR5, which correlate to the degenerative state of the disk. Therefore, disk cells inherit the molecular machinery to

  13. [Dr. Elizabeth Ross: heroine and victim of the World War I in Serbia].

    PubMed

    Mikić, Želimir; Lešić, Aleksandar

    2012-01-01

    At the beginning of 1915, several months after the World War I started, Serbia was in an extremely difficult situation.The country was war-ravaged, full of sick and wounded soldiers, there was a desperate shortage of doctors, nurses and other medical personnel, and the epidemic of typhus fever exploded and violently attacked the entire country. At that time, however, a number of both foreign allied medical missions and individual volunteers, from various countries, mostly from Great Britain, came to Serbia to help. Among them mostly were women, and they were of enormous support to Serbia in that grave situation. It is estimated that there were more than 600 foreign women volunteers in Serbia at that time and that 22 of them died there. Dr. Elizabeth Ross was one of those brave volunteers who came to Serbia early in 1915. That noble Scottish lady doctor was born in 1878 and finished her medical studies at the University of Glasgow in 1901. After graduation she worked in various places in Great Britain until 1909, when she went to Persia (Iran), where she worked until the beginning of the so called Great War. When she heard of the urgent need in Serbia she left Persia as soon as she could and volunteered to serve in Serbia. She came to Kragujevac at the beginning of January 1915, where she worked at the First Military Reserve Hospital, which at that time was actually a typhus hospital. Working there intensively and devotedly for several weeks under shocking conditions she contracted typhus herself and died there on her 37th birthday on February 14th, 1915. She was buried in Kragujevac, next to two British ladies who also died in Serbia of typhus. Her grave was restored in 1980 when the town of Kragujevac started holding commemorations at the graveside every February 14th at noon to honor her and all other brave and noble women who lost their lives helping Serbia at that unfortunate time.

  14. Biogen's portfolio and research efforts in multiple sclerosis: an interview with Dr Ralph Kern.

    PubMed

    Kern, Ralph

    2017-02-01

    Ralph Kern speaks to Laura Dormer, Commissioning Editor: Dr Ralph Kern is Senior Vice President and Head of Worldwide Medical at Biogen in Cambridge, MA, USA. In this role, he oversees Biogen's global therapeutic, regional and country medical teams, global medical operations, as well as medical research and scientific communications functions. Prior to joining Biogen, he was head of the Neuroscience Medical Unit at Novartis Pharmaceuticals Corporation and held various medical and commercial leadership roles at Genzyme Corporation. Prior to joining industry, he was a consultant neurologist at Mount Sinai Hospital and the University Health Network in Toronto, Ontario and was head of the neurology postgraduate academic program at the University of Toronto. Ralph completed neurology postgraduate training at McGill University and completed a masters of health administration from the Institute for Health Policy, Management and Evaluation at the University of Toronto. He is a member of the College of Physicians and Surgeons of Ontario and the Royal College of Physicians and Surgeons of Canada.

  15. [Dr Ante Svalba (1903-1989): promotor of social medicine and public health].

    PubMed

    Bakasun, Vjekoslav

    2009-01-01

    When a healthcare professional sticks to one area of activity, such as protection of human environment, for his entire career, he must leave an indelible mark on his colleagues and local population. Dr Ante Svalba was this kind of a man; he was a physician specialised in hygiene, who persisted in his commitment to improve public health in the wide Rijeka area for nearly sixty active years. He was a true field worker and tireless educator dedicated to improving health culture in all age groups, but especially in schoolchildren. For decades, and nearly to the day he died, he was active in Red Cross work. Ante Svalba was born in Rijeka, and completed primary and secondary school in Rijeka and Susak, respectively. He graduated from the School of Medicine in Zagreb in 1927. For three years he worked at the School of Public Health in Zagreb, and between 1931 and 1942 he was town physician of Susak, until he was interned in Italy with his family. When Italy capitulated he went to Bari and joined anti-fascist resistance. In a place called Grumo he set up a hospital and a medical corps school of the National Liberation Army of Yugoslavia. Having returned to Rijeka, he performed a number of healthcare public offices, of which sanitation inspection was the longest lasting. When he retired in 1965, he took up a position of the head of Hygiene and Epidemiology Department of the Community Health Centre of Opatija until 1972.

  16. Development of ophthalmology in Slovenia and University Eye Hospital in Ljubljana (1890-2010): at the 120th anniversary of the University Eye Hospital in Ljubljana.

    PubMed

    Zupanic Slavec, Zvonka; Slavec, Ksenija; Peternelj Uran, Lejla

    2010-01-01

    Slovenian ophthalmology developed much at the same time as in the rest of the Central Europe). The first Slovenian ophthalmologist was Dr Ludvik Grbec (1805%emdash;1880). The first Slovenian eye department was established within the Ljubljana civil hospital in 1890, and initially counted 34 hospital beds. Under Dr Emil Bock, the department grew to 120 beds by 1916 and saw a number of surgical procedures performed (mainly cataract operations). Dr Bock also founded a department for the treatment of ocular tuberculosis in children. From 1920 to 1958, the department was resumed by Dr Leopold Ješe, a pioneer of Slovenian ophthalmology, the first professor of ophthalmology at the Ljubljana University Faculty of Medicine (1945), author of the first ophthalmology textbook for students (Ophthalmology, 1946), and the father of Slovenian ophthalmological terminology. This article describes the development of ophthalmology in Slovenian hospitals to this day, especially in the Ljubljana Eye Hospital. It remembers the most prominent figures and professional, educational,and scientific achievements. Now in 2010, Slovenia has over 130 ophthalmologists, two departments teaching ophthalmology (within Ljubljana and Maribor University Faculties of Medicine), an internationally recognised ophthalmology specialisation programme, and influential research work published in various journals indexed by Science Citation Index.

  17. In Memoriam: Prof. Dr Dragutin Djurovic (1937-2013)

    NASA Astrophysics Data System (ADS)

    2013-12-01

    Prof. dr Dragutin Djurovic was born in Guca, Serbia, on December 20, 1937. He completed his primary and secondary education in Guca and Cacak. In the period 1956-1958, he studied at the General Military Academy in Belgrade. He enrolled at the Faculty of Sciences and Mathematics - Astronomy Group in 1958 and graduated in 1963. After graduation he went to study visits to Paris (1966) and Bruxelles (1972 and 1975). He obtained his MSc degree in 1970 from the University of Belgrade with a thesis entitled "Application of different types of telescopes for astronomical determination of time". His supervisor for the master thesis was Prof. Zaharije Brkic. Dragutin Djurovic defended his PhD thesis "Contribution to determination of Earth-rotation variations and polar motion" at the University of Belgrade in 1974. Most of the thesis-related research was done in Bruxelles during 1972 under the supervision of Prof. Paul Melchior.

  18. Diagnostic electron microscopy and the influence of Dr. Juan Rosai.

    PubMed

    Wick, Mark R

    2016-09-01

    Transmission electron microscopy (TEM) was introduced by Ruska and Knoll as a laboratory technique in 1933. Thereafter, several decades passed before the methods required for its optimal implementation were fully developed. Early uses of TEM were in Botany, rather than in Medicine; however, isolated publications did catalog the ultrastructural characteristics of several individual human tumor types. Finally, in 1968, Rosai and Rodriguez authored an important article, introducing the concept that TEM could be used for the differential diagnosis of histologically similar neoplasms. This publication heralded the steadily increasing application of TEM in anatomic pathology over the following decade, including continuing contributions by Dr. Juan Rosai. This brief review summarizes his influence on clinical electron microscopy, and lists some of the lesions for which that procedure is still a useful means of analysis.

  19. Careful monitoring of human rights needed -- Dr. Wiwat Rojanapithayakorn.

    PubMed

    1999-12-01

    In his talk, Joint UN Program on HIV/AIDS team leader Dr. Wiwat Rojanapithayakorn made a plea for the careful monitoring of human rights with respect to the HIV/AIDS epidemic. Since the start of the HIV/AIDS pandemic, a total of 47 million people have been infected with HIV, 14 million have died of AIDS, with 33 million afflicted with the virus by the end of 1998. In the wake of this global crisis comes the widespread abuse of human rights and fundamental freedoms worldwide. Many HIV/AIDS patients suffer from discrimination, intolerance, and prejudice. Hence, protection of human rights is crucial to safeguard human dignity in the context of HIV/AIDS, and to warrant an effective public health and social responses to this epidemic. All states, regardless of their political, economic and cultural systems, have the obligation to promote and protect universal human rights standards and fundamental freedoms of all peoples.

  20. Revisiting the Hubble sequence in the SDSS DR7

    NASA Astrophysics Data System (ADS)

    Huertas-Company, M.; Aguerri, J. A. L.; Bernardi, M.; Mei, S.; S´Nchez Almeida, J.

    2011-11-01

    We present an automated morphological classification in 4 types (E, S0, Sab, Scd) of ˜ 700,000 galaxies from the SDSS DR7 spectroscopic sample based on support vector machines. The main new property of the classification is that we associate a probability to each galaxy of being in the four morphological classes instead of assigning a single class. The classification is therefore better adapted to nature where we expect a continuous transition between different morphological types. The algorithm is trained with a visual classification and then compared to several independent visual classifications including the Galaxy Zoo first-release catalog. We find a very good correlation between the automated classification and classical visual ones. The compiled catalog is intended for use in different applications and is therefore publicly available through a dedicated webpage (http://gepicom04.obspm.fr/sdss_morphology/Morphology_2010.html)

  1. The Chymistry of "The Learned Dr Plot" (1640-96).

    PubMed

    Roos, Anna Marie

    2014-01-01

    In the seventeenth century, there were developing norms of openness in the presentation of scientific knowledge that were at odds with traditions of secrecy among chymists, particularly practitioners of chrysopoeia, or the transmutation of metals. This chapter analyzes how Dr. Robert Plot, the first professor of chymistry at Oxford, negotiated these boundaries within an institutional context. I first delineate his chymical and experimental practice, which incorporated procedures from medieval alchemical sources, particularly the Lullian corpus, as well as more novel practices from seventeenth-century chymistry. Then, I analyze how personal and institutional ambitions and economic considerations shaped to what extent Plot negotiated the boundaries between secrecy and the public dissemination of chymical knowledge.

  2. Dr. Arthur Conan Doyle and the case of congenital syphilis.

    PubMed

    Silverstein, Arthur M; Ruggere, Christine

    2006-01-01

    In 1894, Dr. Arthur Conan Doyle wrote "The Third Generation," a short story involving the transmission of congenital syphilis from generation to generation. Analysts of his writings have interpreted the pathogenetic mechanism involved in modern terms: infection of mother by father and then transplacental infection of the fetus. However, a review of the contemporary literature and the history of the concepts of congenital and "hereditary" syphilis demonstrates that the late 19th-century understanding of the process involved a Lamarckian transmission of paternal infection, via the sperm at the moment of conception. It was undoubtedly this concept that Doyle learned in medical school in the late 1870s and that provided the background to his story.

  3. SPECTRO-ASTROMETRY OF WATER IN DR TAURI

    SciTech Connect

    Brown, Logan R.; Troutman, Matthew R.; Gibb, Erika L.

    2013-06-10

    We present high-resolution, near-infrared spectro-astrometric (SA) data for the T Tauri star DR Tau using NIRSPEC at the Keck II telescope. Spectro-astrometry obtains sub-seeing spatial information from emission lines originating in a non-point source object, such as a circumstellar disk. We report the first detection of water SA signatures in a protoplanetary disk. Three water features near 3 {mu}m were averaged together to produce the total signal analyzed. Using a disk model, we constrained the position angle of the disk ({approx}140 Degree-Sign ), the inclination of the disk ({approx}13 Degree-Sign ), and the emitting region of the emission lines ({approx}0.056-0.38 AU).

  4. Dr. Richard Grugel examines an ampoule of a succinonitrile mixture

    NASA Technical Reports Server (NTRS)

    2003-01-01

    On Earth when scientists melt metals, bubbles that form in the molten material can rise to the surface, pop and disappear. In microgravity -- the near-weightless environment created as the International Space Station orbits Earth -- the lighter bubbles do not rise and disappear. Prior space experiments have shown that bubbles often become trapped in the final metal or crystal sample -similar to the bubbles trapped in this sample. In the solid, these bubbles, or porosity, are defects that diminish both the material's strength and usefulness. The Pore Formation and Mobility Investigation will melt samples of a transparent modeling material, succinonitrile and succinonitrile water mixtures, shown here in an ampoule being examined by Dr. Richard Grugel, the principal investigator for the experiment at NASA's Marshall Space Flight Center in Huntsville, Ala. As the samples are processed in space, Grugel will be able to observe how bubbles form in the samples and study their movements and interactions.

  5. Dr. Newell Sill Jenkins: progenitor of cosmetic dentistry.

    PubMed

    Hyson, John M; Swank, Scott D

    2003-08-01

    Dr. Newell Sill Jenkins was one of the pioneer American dentists who took "American dentistry" to Europe. Among his patients were Composer Richard Wagner, and among his friends, Author Mark Twain. He treated some of the crown head of Europe, and yet found time to participate in organized dentistry and conduct research in cosmetic dentistry. He was the father of the porcelain revival in both Europe and America. Unfortunately, Jenkins' Legacy as the chief proponent of cosmetic dentistry in the late 19th and early 20th centuries has been largely ignored by dental historians. In a 20-year period (1896 to 1916), Jenkins published 32 articles in the dental literature on the esthetic advantages of porcelain fillings. It is time to give Jenkins his just recognition.

  6. Chemical Cartography with SDSS-III APOGEE: DR12 Results

    NASA Astrophysics Data System (ADS)

    Hayden, Michael R.; Holtzman, Jon A.; Bovy, Jo; Majewski, Steven R.; Nidever, David L.; Zasowski, Gail; Schiavon, Ricardo P.; Frinchaboy, Peter M.; Hearty, Fred; Allende-Prieto, Carlos; García Pérez, Ana; Robin, Annie; Cunha, Katia M. L.; Beers, Timothy C.; Apogee Team

    2015-01-01

    The SDSS-III Apache Point Observatory Galactic Evolution Experiment (APOGEE) spectrograph provides an unprecedented view of the Milky Way disk, due in part to its ability to observe in the infrared, where the effects of extinction are significantly reduced compared to optical surveys. We present updated results on mean metallicity and chemical abundance gradients using the full three years of APOGEE1 observations and new results of the metallicity distribution function (MDF) and the [α/Fe] vs. [Fe/H] plane at different locations in the Milky Way disk. Our sample comprises nearly high signal-to-noise observations of nearly 100,000 red giant stars taken from SDSS DR12. These observations span the entire Milky Way visible from the northern hemisphere, ranging from the bulge to the edge of the disk (0

  7. User's Manual for FEMOM3DR. Version 1.0

    NASA Technical Reports Server (NTRS)

    Reddy, C. J.

    1998-01-01

    FEMoM3DR is a computer code written in FORTRAN 77 to compute radiation characteristics of antennas on 3D body using combined Finite Element Method (FEM)/Method of Moments (MoM) technique. The code is written to handle different feeding structures like coaxial line, rectangular waveguide, and circular waveguide. This code uses the tetrahedral elements, with vector edge basis functions for FEM and triangular elements with roof-top basis functions for MoM. By virtue of FEM, this code can handle any arbitrary shaped three dimensional bodies with inhomogeneous lossy materials; and due to MoM the computational domain can be terminated in any arbitrary shape. The User's Manual is written to make the user acquainted with the operation of the code. The user is assumed to be familiar with the FORTRAN 77 language and the operating environment of the computers on which the code is intended to run.

  8. Dr. Cheryl Nickerson studies Salmonella in simulated low-g

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Cheryl Nickerson of Tulane University is studying the effects of simulated low-g on a well-known pathogen, Salmonella typhimurium, a bacterium that causes two to four million cases of gastrointestinal illness in the United States each year. While most healthy people recover readily, S. typhimurium can kill people with weakened immune systems. Thus, a simple case of food poisoning could disrupt a space mission. Using the NASA rotating-wall bioreactor, Nickerson cultured S. typhimurium in modeled microgravity. Mice infected with the bacterium died an average of three days faster than the control mice, indicating that S. typhimurium's virulence was enhanced by the bioreactor. Earlier research showed that 3 percent of the genes were altered by exposure to the bioreactor. Nickerson's work earned her a 2001 Presidential Early Career Award for Scientists and Engineers.

  9. Dr. Cheryl Nickerson studying Salmonella at Tulane University

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Cheryl Nickerson (right) of Tulane University is studying the effects of simulated low-g on a well-known pathogen, Salmonella typhimurium, a bacterium that causes two to four million cases of gastrointestinal illness in the United States each year. While most healthy people recover readily, S. typhimurium can kill people with weakened immune systems. Thus, a simple case of food poisoning could disrupt a space mission. Using the NASA rotating-wall bioreactor, Nickerson cultured S. typhimurium in modeled microgravity. Mice infected with the bacterium died an average of three days faster than the control mice, indicating that S. typhimurium's virulence was enhanced by the bioreactor. Earlier research showed that 3 percent of the genes were altered by exposure to the bioreactor. Nickerson's work earned her a 2001 Presidential Early Career Award for Scientists and Engineers.

  10. GPS/DR Error Estimation for Autonomous Vehicle Localization

    PubMed Central

    Lee, Byung-Hyun; Song, Jong-Hwa; Im, Jun-Hyuck; Im, Sung-Hyuck; Heo, Moon-Beom; Jee, Gyu-In

    2015-01-01

    Autonomous vehicles require highly reliable navigation capabilities. For example, a lane-following method cannot be applied in an intersection without lanes, and since typical lane detection is performed using a straight-line model, errors can occur when the lateral distance is estimated in curved sections due to a model mismatch. Therefore, this paper proposes a localization method that uses GPS/DR error estimation based on a lane detection method with curved lane models, stop line detection, and curve matching in order to improve the performance during waypoint following procedures. The advantage of using the proposed method is that position information can be provided for autonomous driving through intersections, in sections with sharp curves, and in curved sections following a straight section. The proposed method was applied in autonomous vehicles at an experimental site to evaluate its performance, and the results indicate that the positioning achieved accuracy at the sub-meter level. PMID:26307997

  11. GPS/DR Error Estimation for Autonomous Vehicle Localization.

    PubMed

    Lee, Byung-Hyun; Song, Jong-Hwa; Im, Jun-Hyuck; Im, Sung-Hyuck; Heo, Moon-Beom; Jee, Gyu-In

    2015-08-21

    Autonomous vehicles require highly reliable navigation capabilities. For example, a lane-following method cannot be applied in an intersection without lanes, and since typical lane detection is performed using a straight-line model, errors can occur when the lateral distance is estimated in curved sections due to a model mismatch. Therefore, this paper proposes a localization method that uses GPS/DR error estimation based on a lane detection method with curved lane models, stop line detection, and curve matching in order to improve the performance during waypoint following procedures. The advantage of using the proposed method is that position information can be provided for autonomous driving through intersections, in sections with sharp curves, and in curved sections following a straight section. The proposed method was applied in autonomous vehicles at an experimental site to evaluate its performance, and the results indicate that the positioning achieved accuracy at the sub-meter level.

  12. A 10,000 YEAR OLD EXPLOSION IN DR21

    SciTech Connect

    Zapata, Luis A.; Perez-Goytia, Nadia; Rodriguez, Luis F.; Loinard, Laurent; Schmid-Burgk, Johannes; Ho, Paul T. P.; Cruz-Gonzalez, Irene

    2013-03-10

    Sensitive high angular resolution ({approx}2'') CO(2-1) line observations made with the Submillimeter Array of the flow emanating from the high-mass star-forming region DR21 located in the Cygnus X molecular cloud are presented. These new interferometric observations indicate that this well known enigmatic outflow appears to have been produced by an explosive event that took place about 10,000 years ago, and that might be related to the disintegration of a massive stellar system such as the one that occurred in Orion Becklin-Neugebauer/Kleinman-Low 500 years ago, but about 20 times more energetic. This result therefore argues in favor of the idea that the disintegration of young stellar systems perhaps is a frequent phenomenon present during the formation of massive stars. However, many more theoretical and observational studies are still needed to confirm our hypothesis.

  13. Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.

    PubMed Central

    Zechel, C; Shen, X Q; Chambon, P; Gronemeyer, H

    1994-01-01

    We have previously reported that the binding site repertoires of heterodimers formed between retinoid X receptor (RXR) and either retinoic acid receptor (RAR) or thyroid hormone receptor (TR) bound to response elements consisting of directly repeated PuG(G/T)TCA motifs spaced by 1-5 bp [direct repeat (DR) elements 1-5] are highly similar to those of their corresponding DNA binding domains (DBDs). We have now mapped the dimerization surfaces located in the DBDs of RXR, RAR and TR, which are responsible for cooperative interaction on DR4 (RXR and TR) and DR5 (RXR and RAR). The D-box of the C-terminal CII finger of RXR provides one of the surfaces which is specifically required for the formation of the heterodimerization interfaces on both DR4 and DR5. Heterodimerization with the RXR DBD on DR5 specifically requires the tip of the RAR CI finger as the complementary surface, while a 7 amino acid sequence encompassing the 'prefinger region', but not the TR CI finger, is specifically required for efficient dimerization of TR and RXR DBDs on DR4. Importantly, DBD swapping experiments demonstrate not only that the binding site repertoires of the full-length receptors are dictated by those of their DBDs, but also that the formation of distinct dimerization interfaces between the DBDs are the critical determinants for cooperative DNA binding of these receptors to specific DRs. Images PMID:8137825

  14. Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5.

    PubMed

    Choi, Soon-Young; Kim, Min-Jung; Chung, Hee Yong; Lee, Su-Jae; Jang, Young-Ju

    2007-01-01

    Sensitization of cancer cells to TRAIL could improve the effectiveness of TRAIL as an anticancer agent. We explored whether TRAIL in combination with phytosphingosine could sensitize cancer cells to TRAIL. The combined treatment enhanced synergistic apoptotic cell death of Jurkat T cells, compared to TRAIL or phytosphingosine alone. Enhanced apoptosis in response to the combination treatment was associated with caspase-8 activation-mediated Bax and Bak activation and mitochondrial dysfunction. The combination treatment also resulted in synergistic up-regulation of TRAIL receptor R1 (DR4) and R2 (DR5). siRNA targeting of DR5 significantly attenuated the combination treatment-induced caspase-8 activation, mitochondrial dysfunction, and apoptotic cell death. Upon stimulation of cells with the combination treatment, NF-kappaB was activated. Moreover, siRNA targeting of NF-kappaB significantly attenuated the combination treatment-induced DR4 and DR5 expression and receptor-mediated caspase-8 activation. These results indicate that phytosphingosine sensitizes cancer cells to TRAIL through the synergistic up-regulation of DR4 and DR5 in an NF-kappaB-dependent fashion resulting in caspase-8 activation and subsequent mitochondrial dysfunction. These findings support the potential application of combination treatment with TRAIL and phytosphingosine in the treatment of cancers that are less sensitive to TRAIL.

  15. DR 21(OH): A HIGHLY FRAGMENTED, MAGNETIZED, TURBULENT DENSE CORE

    SciTech Connect

    Girart, J. M.; Frau, P.; Zhang, Q.; Koch, P. M.; Tang, Y.-W.; Lai, S.-P.; Ho, P. T. P.; Qiu, K.

    2013-07-20

    We present high angular resolution observations of the massive star-forming core DR21(OH) at 880 {mu}m using the Submillimeter Array (SMA). The dense core exhibits an overall velocity gradient in a Keplerian-like pattern, which breaks at the center of the core where SMA 6 and SMA 7 are located. The dust polarization shows a complex magnetic field, compatible with a toroidal configuration. This is in contrast with the large, parsec-scale filament that surrounds the core, where there is a smooth magnetic field. The total magnetic field strengths in the filament and in the core are 0.9 and 2.1 mG, respectively. We found evidence of magnetic field diffusion at the core scales, far beyond the expected value for ambipolar diffusion. It is possible that the diffusion arises from fast magnetic reconnection in the presence of turbulence. The dynamics of the DR 21(OH) core appear to be controlled energetically in equal parts by the magnetic field, magnetohydrodynamic turbulence, and the angular momentum. The effect of the angular momentum (this is a fast rotating core) is probably causing the observed toroidal field configuration. Yet, gravitation overwhelms all the forces, making this a clear supercritical core with a mass-to-flux ratio of {approx_equal} 6 times the critical value. However, simulations show that this is not enough for the high level of fragmentation observed at 1000 AU scales. Thus, rotation and outflow feedback are probably the main causes of the observed fragmentation.

  16. Can hospitals compete on quality? Hospital competition.

    PubMed

    Sadat, Somayeh; Abouee-Mehrizi, Hossein; Carter, Michael W

    2015-09-01

    In this paper, we consider two hospitals with different perceived quality of care competing to capture a fraction of the total market demand. Patients select the hospital that provides the highest utility, which is a function of price and the patient's perceived quality of life during their life expectancy. We consider a market with a single class of patients and show that depending on the market demand and perceived quality of care of the hospitals, patients may enjoy a positive utility. Moreover, hospitals share the market demand based on their perceived quality of care and capacity. We also show that in a monopoly market (a market with a single hospital) the optimal demand captured by the hospital is independent of the perceived quality of care. We investigate the effects of different parameters including the market demand, hospitals' capacities, and perceived quality of care on the fraction of the demand that each hospital captures using some numerical examples.

  17. GENESI-DR Portal: a scientific gateway to distributed repositories

    NASA Astrophysics Data System (ADS)

    Goncalves, Pedro; Brito, Fabrice; D'Andria, Fabio; Cossu, Roberto; Fusco, Luigi

    2010-05-01

    GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. "Discovering" which data are available on a "geospatial web" is one of the main challenges ES scientists have to face today. Some well- known data sets are referred to in many places, available from many sources. For core information with a common purpose many copies are distributed, e.g., VMap0, Landsat, and SRTM. Other data sets in low or local demand may only be found in a few places and niche communities. Relevant services, results of analysis, applications and tools are accessible in a very scattered and uncoordinated way, often through individual initiatives from Earth Observation mission operators, scientific institutes dealing with ground measurements, service companies or data catalogues. In the discourse of Spatial Data Infrastructures, there are "catalogue services" - directories containing information on where spatial data and services can be found. For metadata "records" describing spatial data and services, there are "registries". The Geospatial industry coins specifications for search interfaces, where it might do better to reach out to other information retrieval and Internet communities. These considerations are the basis for the GENESI-DR scientific portal, which adopts a simple model allowing the geo-spatial classification and discovery of

  18. Changing hospital payments: implications for teaching hospitals.

    PubMed

    Bentley, J D

    1983-09-01

    Hospitals cannot continue to view themselves only as social institutions whose performance will be assessed on the good they do. Teaching hospitals, in particular, cannot view themselves simply as distinctive combinations of social and educational institutions. Under Medicare's prospective pricing system, the hospital's role as production system is enhanced, and all hospitals must learn to balance the new economic realities as they work with their medical staff to adapt to a changed future.

  19. Going to the Hospital

    MedlinePlus

    ... Happens in the Operating Room? Going to the Hospital KidsHealth > For Kids > Going to the Hospital Print ... you flowers, balloons, or other treats! previous continue Hospital People You'll meet lots of people in ...

  20. Dr. Norman Thagard, crewmember for STS-7, during training on the KC-135

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Dr. Norman E. Thagard, a physician assigned to mission specialist duties on STS-7, familiarizes himself with the donning and doffing of the extravehicular mobility unit (EMU) onboard NASA's zero gravity aircraft, the KC-135. Dr. Thagard has anchored his EMU to a 'lifeline' in the KC-135 as he awaits the next weightless session. A number of technicians and engineers assist Dr. Thagard in the training procedures.

  1. SDSS DR4: Progress on the Hot Wire Dwarf Luminosity Function

    DTIC Science & Technology

    2009-01-01

    SDSS DR4: Progress on the hot white dwarf luminosity function This article has been downloaded from IOPscience. Please scroll down to see the full...TITLE AND SUBTITLE SDSS DR4: progress on the hot white dwarf luminosity function 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...Sloan Digital Sky Survey ( SDSS ) data release 4 (DR4) WD catalog data allowed us to obtain a luminosity function (LF)for the hottest WDs. The LF was

  2. Donor dependent, interferon-γ induced HLA-DR expression on human neutrophils in vivo

    PubMed Central

    REINISCH, W; LICHTENBERGER, C; STEGER, G; TILLINGER, W; SCHEINER, O; GANGL, A; MAURER, D; WILLHEIM, M

    2003-01-01

    Neutrophils are effector cells of innate immune responses. Stimulated by interferon-γ (IFN-γ) to express HLA-DR, neutrophils acquire accessory cell functions for superantigen-mediated T cell activation. In vitro HLA-DR induction on neutrophils varies in a functionally relevant way as levels of MHC class II expression and magnitude of neutrophil induced T cell responses are correlated functions. The aim of this study was to assess whether IFN-γ induces HLA-DR on human neutrophils in a donor dependent fashion in vivo and to define regulatory events operative in MHC class II expression of neutrophils. In vivo administration of rhIFN-γ in 55 patients with renal cell carcinoma resulted in a varying increase of HLA-DR on neutrophils. By setting a cut-off for response at>10% HLA-DR positive neutrophils, HLA-DR responders (51%) were as frequent as nonresponders (49%). In vivo kinetic studies revealed a peak expression of HLA-DR on neutrophils 48 h after rhIFN-γ application, while nonresponders remained HLA-DR negative over a 72-h period. In vitro IFN-γ stimulated neutrophils recapitulated the response profiles observed in vivo. No differences in IFN-γ dependent CD64 and invariant chain expression, and IFN-γ serum levels were observed among the response subgroups. HLA-DR mRNA was detected in neutrophils from rhIFN-γ treated responders and nonresponders, HLA-DR protein solely in lysates of responder neutrophils. IFN-γ stimulated HLA-DR expression on neutrophils is subject to donor dependent variations in vivo, which result from rather post-transcriptional than transcriptional regulation. Due to their abundance in inflammatory reactions heterogeneous HLA-DR expression by neutrophils could determine the outcome of superantigen-driven diseases. PMID:12930377

  3. Safety evaluation for packaging for 1720-DR sodium-filled tank

    SciTech Connect

    Mercado, M.S.

    1996-03-09

    Preparations are under way to sell the sodium stored in the 1720-DR tank in the 1720-DR building. This will require that the tank, as well as the 1720-DR facility, be moved to the 300 Area, so that the sodium may be melted and transferred into a railroad tanker car. Because the sodium is a hazardous material and is being shipped in a nonspecification packaging, a safety evaluation for packaging (SEP) is required. This SEP approves the sodium-filled tank for a single shipment from the 105-DR area to the 300 Area.

  4. Introducing Dr. Varga and Some of His Ideas for Probability in the Junior School

    ERIC Educational Resources Information Center

    Sherwood, Philip

    1978-01-01

    Dr. Varga's description of the beginning of the Hungarian Project (primary mathematics) is recorded along with two examples of assignments to generate exploration and discussion involving probability. (MN)

  5. Characteristics of dr1790 disruptant and its functional analysis in Deinococcus radiodurans.

    PubMed

    Cheng, Jianhui; Wang, Hu; Xu, Xin; Wang, Liangyan; Tian, Bing; Hua, Yuejin

    2015-06-01

    Deinococcus radiodurans (DR) is an extremophile that is well known for its resistance to radiation, oxidants and desiccation. The gene dr1790 of D. radiodurans was predicted to encode a yellow-related protein. The primary objective of the present study was to characterize the biological function of the DR1790 protein, which is a member of the ancient yellow/major royal jelly (MRJ) protein family, in prokaryotes. Fluorescence labeling demonstrated that the yellow-related protein encoded by dr1790 is a membrane protein. The deletion of the dr1790 gene decreased the cell growth rate and sensitivity to hydrogen peroxide and radiation and increased the membrane permeability of D. radiodurans. Transcript profiling by microarray and RT-PCR analyses of the dr1790 deletion mutant suggested that some genes that are involved in protein secretion and transport were strongly suppressed, while other genes that are involved in protein quality control, such as chaperones and proteases, were induced. In addition, the expression of genes with predicted functions that are involved in antioxidant systems, electron transport, and energy metabolism was significantly altered through the disruption of dr1790. Moreover, the results of proteomic analyses using 2-DE and MS also demonstrated that DR1790 contributed to D. radiodurans survival. Taken together, these results indicate that the DR1790 protein from the ancient yellow protein family plays a pleiotropic role in the survival of prokaryotic cells and contributes to the extraordinary resistance of D. radiodurans against oxidative and radiation stresses.

  6. [Interpreting the hospitalization experiences of patients with spine lesion].

    PubMed

    de Albuquerque, Ana Lúcia Pereira; de Freitas, Consuelo Helena Aires; Jorge, Maria Salete Bessa

    2009-01-01

    Qualitative study with theoretical axis in symbolic interactionism interpretative of Norman Denzin that had as objective to comprehend the meanings of experiences lived by being victim of spine lesion in context hospital and to describe the narratives in range of experiences lived. The subjects of research were seven patient victims of spine lesion traumatic hospitalized in unity of neurology of Institute Dr. José Frota, sited in Fortaleza/Ce. Interpreted hard fronting to balance of oneself, given to sudden breaking of trajectory of their lives, the organic alterations acquired that pass to be motives of fears, uncertain, non-comfort and menace to life that had along their families.

  7. Critical Access Hospitals (CAH)

    MedlinePlus

    ... use requirements for Critical Access Hospitals related to Electronic Health Records (EHRs)? Critical Access Hospital (CAH) are eligible for Electronic Health Record (EHR) incentive payments and can receive ...

  8. HA/DR: Is USPACOM "Ready on Arrival"

    DTIC Science & Technology

    2009-05-04

    maritime forces of the U.S. military. 8 AGING AND OBSOLETE ASSETS “[The Hospital Ships] are wonderful ships, but they‟re dinosaurs ...ships as “ dinosaurs . . . designed in the 70‟s, built in the 80‟s, and frankly [now] obsolete.” 34 TRAINING AND READINESS “Unfamiliarity with

  9. Star Formation in the DR21 Region (A)

    NASA Technical Reports Server (NTRS)

    2004-01-01

    [figure removed for brevity, see original site] Annotated mosaic

    Hidden behind a shroud of dust in the constellation Cygnus is a stellar nursery called DR21, which is giving birth to some of the most massive stars in our galaxy. Visible light images reveal no trace of this interstellar cauldron because of heavy dust obscuration. In fact, visible light is attenuated in DR21 by a factor of more than 10,000,000,000,000,000,000,000,000,000,000,000,000,000 (ten thousand trillion heptillion).

    New images from NASA's Spitzer Space Telescope allow us to peek behind the cosmic veil and pinpoint one of the most massive natal stars yet seen in our Milky Way galaxy. The never-before-seen star is 100,000 times as bright as the Sun. Also revealed for the first time is a powerful outflow of hot gas emanating from this star and bursting through a giant molecular cloud.

    The colorful image (top panel) is a large-scale composite mosaic assembled from data collected at a variety of different wavelengths. Views at visible wavelengths appear blue, near-infrared light is depicted as green, and mid-infrared data from the InfraRed Array Camera (IRAC) aboard NASA's Spitzer Space Telescope is portrayed as red. The result is a contrast between structures seen in visible light (blue) and those observed in the infrared (yellow and red). A quick glance shows that most of the action in this image is revealed to the unique eyes of Spitzer. The image covers an area about two times that of a full moon.

    Each of the constituent images is shown below the large mosaic. The Digital Sky Survey (DSS) image (lower left) provides a familiar view of deep space, with stars scattered around a dark field. The reddish hue is from gas heated by foreground stars in this region. This fluorescence fades away in the near-infrared Two-Micron All-Sky Survey (2MASS) image (lower center), but other features start to appear through the obscuring clouds of dust, now increasingly transparent. Many more

  10. Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC).

    PubMed

    Berger, Cedric N; Billker, Oliver; Meyer, Thomas F; Servin, Alain L; Kansau, Imad

    2004-05-01

    Little is known about the molecular bases underlying the virulence of diffusely adhering Escherichia coli (DAEC) harbouring the Afa/Dr family of adhesins. These adhesins recognize as receptors the GPI-anchored proteins CD55 (decay-accelerating factor, DAF) and CD66e (carcinoembryonic antigen, CEA). CD66e is a member of the CEA-related cell adhesion molecules (CEACAM) family, comprising seven members. We analysed the interactions of Afa/Dr DAEC with the CEACAMs using CEACAM-expressing CHO and HeLa cells. The results demonstrate that only E. coli expressing a subfamily of Afa/Dr adhesins, named here Afa/Dr-I, including Dr, F1845 and AfaE-III adhesins, bound onto CHO cells expressing CEACAM1, CEA or CEACAM6. Whereas all the Afa/Dr adhesins elicit recruitment of CD55 around adhering bacteria, only the Afa/Dr-I subfamily elicits the recruitment of CEACAM1, CEA and CEACAM6. In addition, although CEACAM3 is not recognized as a receptor by the subfamily of Afa/Dr adhesins, it is recruited around bacteria in HeLa cells. The recruited CEACAM1, CEA and CEACAM6 around adhering bacteria resist totally or in part a detergent extraction, whereas the recruited CEACAM3 does not. Finally, the results show that recognition of CEA and CEACAM6, but not CEACAM1, is accompanied by tight attachment to bacteria of cell surface microvilli-like extensions, which are elongated. Moreover, recognition of CEA is accompanied by an activation of the Rho GTPase Cdc42 and by a phosphorylation of ERM, which in turn elicit the observed cell surface microvilli-like extensions.

  11. Specialty hospitals: can general hospitals compete?

    PubMed

    Dummit, Laura A

    2005-07-13

    The rapid increase in specialty cardiac, surgical, and orthopedic hospitals has captured the attention of general hospitals and policymakers. Although the number of specialty hospitals remains small in absolute terms, their entry into certain health care markets has fueled arguments about the rules of "fair" competition among health care providers. To allow the smoke to clear, Congress effectively stalled the growth in new specialty hospitals by temporarily prohibiting physicians from referring Medicare or Medicaid patients to specialty hospitals in which they had an ownership interest. During this 18-month moratorium, which expired June 8, 2005, two mandated studies of specialty hospitals provided information to help assess their potential effect on health care delivery. This issue brief discusses the research on specialty hospitals, including their payments under Medicare's hospital inpatient payment system, the quality and cost of care they deliver, their effect on general hospitals and on overall health care delivery, and the regulatory and legal environment in which they have proliferated. It concludes with open issues concerning physician self-referral and the role of general hospitals in providing a range of health care services.

  12. Measuring Rural Hospital Quality

    ERIC Educational Resources Information Center

    Moscovice, Ira; Wholey, Douglas R.; Klingner, Jill; Knott, Astrid

    2004-01-01

    Increased interest in the measurement of hospital quality has been stimulated by accrediting bodies, purchaser coalitions, government agencies, and other entities. This paper examines quality measurement for hospitals in rural settings. We seek to identify rural hospital quality measures that reflect quality in all hospitals and that are sensitive…

  13. Hospital marketing revisited.

    PubMed

    Costello, M M

    1987-05-01

    With more hospitals embracing the marketing function in their organizational management over the past decade, hospital marketing can no longer be considered a fad. However, a review of hospital marketing efforts as reported in the professional literature indicates that hospitals must pay greater attention to the marketing mix elements of service, price and distribution channels as their programs mature.

  14. Influence of Granulocyte-Macrophage Colony-Stimulating Factor or Influenza Vaccination on HLA-DR, Infection and Delirium Days in Immunosuppressed Surgical Patients: Double Blind, Randomised Controlled Trial

    PubMed Central

    Lachmann, Gunnar; Renius, Markus; von Haefen, Clarissa; Wernecke, Klaus-Dieter; Bahra, Marcus; Schiemann, Alexander; Paupers, Marco; Meisel, Christian

    2015-01-01

    Purpose Surgical patients are at high risk for developing infectious complications and postoperative delirium. Prolonged infections and delirium result in worse outcome. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and influenza vaccination are known to increase HLA-DR on monocytes and improve immune reactivity. This study aimed to investigate whether GM-CSF or vaccination reverses monocyte deactivation. Secondary aims were whether it decreases infection and delirium days after esophageal or pancreatic resection over time. Methods In this prospective, randomized, placebo-controlled, double-blind, double dummy trial setting on an interdisciplinary ICU of a university hospital 61 patients with immunosuppression (monocytic HLA-DR [mHLA-DR] <10,000 monoclonal antibodies [mAb] per cell) on the first day after esophageal or pancreatic resection were treated with either GM-CSF (250 μg/m2/d), influenza vaccination (Mutagrip 0.5 ml/d) or placebo for a maximum of 3 consecutive days if mHLA-DR remained below 10,000 mAb per cell. HLA-DR on monocytes was measured daily until day 5 after surgery. Infections and delirium were followed up for 9 days after surgery. Primary outcome was HLA-DR on monocytes, and secondary outcomes were duration of infection and delirium. Results mHLA-DR was significantly increased compared to placebo (p < 0.001) and influenza vaccination (p < 0.001) on the second postoperative day. Compared with placebo, GM-CSF-treated patients revealed shorter duration of infection (p < 0.001); the duration of delirium was increased after vaccination (p = 0.003). Conclusion Treatment with GM-CSF in patients with postoperative immune suppression was safe and effective in restoring monocytic immune competence. Furthermore, therapy with GM-CSF reduced duration of infection in immune compromised patients. However, influenza vaccination increased duration of delirium after major surgery. Trial Registration www.controlled-trials.com ISRCTN27114642 PMID

  15. [Life and work of Dr. Jovan Jovanović Zmaj].

    PubMed

    Lesić, Aleksandar; Bumbasirević, Marko; Zizić-Borjanović, Slavica

    2006-10-01

    The year of 2004 was the 100th anniversary of death of the poet and physician Dr. Jovan Jovanović Zmaj. Jovan Jovanović Zmaj was born in 1833 in Novi Sad, and died in 1904 in Sremska Kamenica J.J. Zmaj himself studied law and worked in the Novi Sad magistrate court. It was not until he turned 30 that he began practicing medicine. He developed as a poet as early as during his studies. He remained loyal to the vocations of physician and poet throughout his life. He wrote over 5000 poems, ranging from those for children through those for adults and those with which he addressed the rulers satirically. He was a founder of a number of magazines (Javor, Neven, Komarac, Danica). At that time of Romanticism, the work of J.J. Zmaj also had a national character. However, he succeeded in achieving something more: he introduced a literary genre till then unknown in Serb literature--literature for children. Through his genre he promoted not only Serbian language but also hygiene, by which he played a significant health care role, similar to that played by his friend Milan Jovanović Batut, only from a different aspect. He also used to draw, and his drawing of the emblem of the Serbian Literary Association has remained on the cover of every book published by it until these days.

  16. [Dr. Choi Myung-Hak, the first modern Korean anatomist].

    PubMed

    Park, H W; Yeo, I S

    1992-01-01

    Though it is known that the concept of anatomy was introduced in the age of Three Kingdoms, anatomy in modern sense meaning was introduced in late Chosun Dynasty by western missionary doctors. From that time on the lecture of anatomy was not given by anatomists until early 1910s. The first Korean anatomist of medical school graduates was Choi Myung Hak, graduated from Severance Union Medical College (SUMC) in 1926. He was born in 1898 at Ham Heung (Ham Gyung Nam Do Province), and entered SUMC in 1922 and graduated in 1926. He was in charge of anatomy for two years after graduation, and then he went to Kyoto Imperial University Medical College (KIUMC) and reserched under the direction of Dr. Ogawa in the field of experimental embryology and histology. He returned to Korea in 1930 and then became a lecturer in January 1931. His Doctorial thesis was recepted by KIUMC on April 18th 1932. So he became the first Korean Doctor of anatomy. He promoted to professor in February 1922. His publications can be seen in Folia anatomica Japonica. In 1934 he became a councillor of the Japanese Association of Anatomist. He resigned SUMC because of some kind of problem of the school. From that time on Chung, Il-Chun who was appointed as a lecturer in 1934 was in charge of department of anatomy.

  17. 2012 DR30, The Most Distant Solar System Object

    NASA Astrophysics Data System (ADS)

    Kiss, Csaba; Szabó, G.; Pál, A.; Kiss, L.; Sárneczky, K.; Müller, T.; Vilenius, E.; Santos-Sanz, P.; Lellouch, E.; Conn, B.; Ortiz, J.; Duffard, R.; Morales, N.; Horner, J.; Bannister, M.; Stansberry, J.

    2012-10-01

    2012 DR30, the most distant TNO in the Solar System (a=1103 AU) has recently been observed with the Herschel Space Observatory. Radiometric model results using the far-infrared fluxes and visual range data show a dark and cratered surface (p_V = 6%) and provide a diameter of 200km. If considered as a Centaur, this is the fifth largest object known in this dynamical class. Recent visual range measurements indicate the presence of methane ice on the surface, a feature that has been seen previously for objects with diameters of >=1000km only (like Eris, Makemake and Pluto). The presence of methane ice can be explained assuming that the object spent most of its lifetime in a very cold environment and has been recently placed to its present orbit. This scenario is in agreement with the results of a dynamical study of the object's orbit, also suggesting an Oort-cloud origin. This research has been supported by the following grants: (1) The PECS program of the European Space Agency (ESA) and the Hungarian Space Office, PECS-98073; (2) C.K. and A.P. acknowledges the support of the Bolyai Research Fellowship of the Hungarian Academy of Sciences.

  18. Reflections of a soon-to-be former DR

    SciTech Connect

    Larson, N.I.

    1997-12-31

    SRP, formerly known as Salt River Project, is actually a combination of two organizations, The Salt River Valley Water Users` Association (the {open_quotes}Association{close_quotes}), and the Salt River Project Agricultural Improvement and Power District (the {open_quotes}District{close_quotes}). The Association was incorporated under the laws of the Territory of Arizona in 1903, and is one of the first projects authorized under the Federal Reclamation Act of 1902. The District was formed in 1937 as a political subdivision of the State of Arizona, and is responsible for the construction, operation and maintenance of the Electric System and the irrigation and water supply system. Generation and sale of electrical power and energy represent a significant portion of the District`s investment and revenues. SRP has a total capability of over 5000 MW from hydroelectric, thermal and purchased sources, Of this, almost 2400 MW is provided by Title IV, Phase II affected units. Phase II units must comply with the SO{sub 2} allowance program starting in the year 2000. SRP operates four facilities having Title IV units. The implementation of Title IV requires the selection of a Designated Representative (DR) to represent the utility and all utilities in the participation plants the utility may operate, to be responsible for reporting emissions of sulfur dioxide and oxides of nitrogen to the United States Environmental Protection Agency on a quarterly and annual basis and certify to the accuracy and completeness of the information.

  19. 2015 AMCA Memorial Lecture Honoree: Dr. Richard Floyd Darsie, Jr.

    PubMed

    Day, Jonathan F

    2015-12-01

    Richard Floyd Darsie, Jr. (1915-2014) is the 2015 American Mosquito Control Association Memorial Lecture Honoree. He was one of the greatest mosquito taxonomists of the 20th century and died peacefully on April 10, 2014, in Grove City, PA, at the age of 99 after a professional career that spanned eight decades. Dick's broad areas of interest and training made him a versatile scientist, teacher, and researcher. His intense interest in adult and immature mosquito morphology and taxonomy, as well as mosquito distribution and bionomics, started early in his career at two early academic postings: Franklin and Marshall College (1949-54) and the University of Delaware (1954-62). Dick would take his mosquito interests with him to postings and research projects around the world: Nepal, the Philippines, Atlanta, El Salvador, Guatemala, Fort Collins, South Carolina, Argentina, and Florida. His travels and studies would make him an international expert on mosquito taxonomy. Dick's legacy lives on in the hundreds of students from across the globe who learned mosquito identification skills from this world-renowned mosquito taxonomist. All will proudly profess that, "I learned mosquito identification from Dr. Darsie." And that is all that is needed to prove one's credentials in the field, learning the art from the best there is.

  20. Dr. Monaco Examines Lab-on a-Chip

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Lisa Monaco, Marshall Space Flight Center's (MSFC's) project scientist for the Lab-on-a-Chip Applications Development (LOCAD) program, examines a lab on a chip. The small dots are actually ports where fluids and chemicals can be mixed or samples can be collected for testing. Tiny channels, only clearly visible under a microscope, form pathways between the ports. Many chemical and biological processes, previously conducted on large pieces of laboratory equipment, can now be performed on these small glass or plastic plates. Monaco and other researchers at MSFC in Huntsville, Alabama, are customizing the chips to be used for many space applications, such as monitoring microbes inside spacecraft and detecting life on other planets. The portable, handheld Lab-on-a Chip Application Development Portable Test System (LOCAD-PTS) made its debut flight aboard Discovery during the STS-116 mission launched December 9, 2006. The system allowed crew members to monitor their environment for problematic contaminants such as yeast, mold, and even E.coli, and salmonella. Once LOCAD-PTS reached the International Space Station (ISS), the Marshall team continued to manage the experiment, monitoring the study from a console in the Payload Operations Center at MSFC. The results of these studies will help NASA researchers refine the technology for future Moon and Mars missions. (NASA/MSFC/D.Stoffer)

  1. Three moving groups detected in the LAMOST DR1 archive

    SciTech Connect

    Zhao, J. K.; Zhao, G.; Chen, Y. Q.; Tan, K. F.; Oswalt, T. D.; Zhang, Y. E-mail: oswaltt1@erau.edu

    2014-05-20

    We analyze the kinematics of thick disk and halo stars observed by the Large Sky Area Multi-Object Fiber Spectroscopic Telescope. We have constructed a sample of 7993 F, G, and K nearby main-sequence stars (d < 2 kpc) with estimates of position (x, y, z) and space velocity (U, V, W) based on color and proper motion from the Sloan Digital Sky Survey DR9 catalog. Three 'phase-space overdensities' are identified in (V, √(U{sup 2}+2V{sup 2})) with significance levels of σ > 3. Two of them (the Hyades-Pleiades stream and the Arcturus-AF06 stream) have been identified previously. We also find evidence for a new stream (centered at V ∼ –180 km s{sup –1}) in the halo. The formation mechanisms of these three streams are analyzed. Our results support the hypothesis that the Arcturus-AF06 stream and the new stream originated from the debris of a disrupted satellite, while the Hyades-Pleiades stream has a dynamical origin.

  2. UCAC5: New Proper Motions Using Gaia DR1

    NASA Astrophysics Data System (ADS)

    Zacharias, N.; Finch, C.; Frouard, J.

    2017-04-01

    New astrometric reductions of the US Naval Observatory CCD Astrograph Catalog (UCAC) all-sky observations were performed from first principles using the TGAS stars in the 8–11 mag range as the reference star catalog. Significant improvements in the astrometric solutions were obtained, and the UCAC5 catalog of mean positions at a mean epoch near 2001 was generated. By combining UCAC5 with Gaia DR1 data, new proper motions were obtained for over 107 million stars on the Gaia coordinate system, with typical accuracies of 1–2 mas yr‑1 (R = 11–15 mag) and about 5 mas yr‑1 at 16th mag. Proper motions of most TGAS stars are improved over their Gaia data and the precision level of TGAS proper motions is extended to many millions more, fainter stars. External comparisons were made using stellar cluster fields and extragalactic sources. The TGAS data allow us to derive the limiting precision of the UCAC x, y data, which is significantly better than1/100 pixel.

  3. Competition among hospitals.

    PubMed

    Noether, M

    1988-09-01

    The traditional view of hospital competition has posited that hospitals compete primarily along 'quality' dimensions, in the form of fancy equipment to attract admitting physicians and pleasant surroundings to entice patients. Price competition among hospitals is thought to be non-existent. This paper estimates the effects of various hospital market characteristics on hospital prices and expenses in an attempt to determine the form of hospital competition. The results suggest that both price and quality competition are greater in markets that are less concentrated, although the net effect of the two on prices is insignificant. It appears, therefore, that, despite important distortions, hospital markets are not immune to standard competitive forces.

  4. NCI's Dr. Barry Kramer on PBS NewsHour | Division of Cancer Prevention

    Cancer.gov

    Talking about New Cancer Definitions to Avoid Unnecessary Treatments. A panel of doctors and scientists proposed a change to the definition of cancer, in hopes of shifting the way we think about and treat the disease. Gwen Ifill discusses the recommendation with Dr. Barnett Kramer of the National Cancer Institute and Dr. Larry Norton of the Memorial Sloan-Kettering Cancer Center... |

  5. 78 FR 7438 - Prospective Grant of Exclusive License: Development of Human Monoclonal Antibodies Against DR4

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... Human Monoclonal Antibodies Against DR4 AGENCY: National Institutes of Health, Public Health Service... Monoclonal Antibodies Against DR4'' (HHS Ref. No. E-158-2010/0) to Customized Biosciences, Inc., which is... relates to the development of two human monoclonal antibodies (mAbs) that bind to death receptor 4...

  6. Vikrant Sahasrabuddhe, MBBS, MPH, DrPH | Division of Cancer Prevention

    Cancer.gov

    Dr. Vikrant Sahasrabuddhe received his medical degree from the University of Pune in India, his master's and doctorate degrees in public health from the University of Alabama at Birmingham, and completed fellowship training in epidemiology at the Johns Hopkins University Bloomberg School of Public Health and at the National Cancer Institute. Before joining NCI in 2015, Dr. |

  7. Annotated Bibliography of Dr Salmani Nodoushan's Research on Education and Language Teaching

    ERIC Educational Resources Information Center

    Etemadfar Kashani, Abbas Ali

    2016-01-01

    This is an annotated bibliography of the research conducted on education and language teaching and assessment by Dr. Mohammad Ali Salmani Nodoushan in the past 25 years. This bibliography is a precise picture of the current state of education and language teaching and assessment in Iran. Dr. Salmani Nodoushan is the most distinguished Iranian…

  8. [Dr Guillermo Contreras Da Silva, a relevant figure in the development of Chilean microbiology].

    PubMed

    Cabello, Felipe C

    2008-02-01

    The influence of the work of Dr. Guillermo Contreras Da Silva and his colaborators on the evolution of microbiology in Chile is briefly analyzed. Dr. Contreras was trained in modern virology at Yale University with Dr. J. Melnick under the sponsorhip of the Rockefeller Foundation. During this training, he used serological methods to classify Cocksakie viruses. After his return to Chile, he studied the epidemiology of enteroviruses, including poliovirus. His laboratory, the country's first in modern virology, took an active role in Chile's first Sabin polio vaccination in 1961. Dr. Contreras and his group transformed the teaching and the character of microbiology in Chile from a descriptive medically oriented discipline into an autonomous, quantitative and experimental science. They modernized microbiology with the introduction of molecular biology and microbial genetics and fostered collaborations with allied biological sciences. Dr. Contreras was a Guggenheim Fellow, and until his retirement, was the Chief of the Viral Products Division, Bureau of Biologies, Ottawa, Canada.

  9. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules.

    PubMed

    Denzin, L K; Hammond, C; Cresswell, P

    1996-12-01

    Major histocompatibility complex (MHC) class II-positive cell lines which lack HLA-DM expression accumulate class II molecules associated with residual invariant (I) chain fragments (class II-associated invariant chain peptides [CLIP]). In vitro, HLA-DM catalyzes CLIP dissociation from class II-CLIP complexes, promoting binding of antigenic peptides. Here the physical interaction of HLA-DM with HLA-DR molecules was investigated. HLA-DM complexes with class II molecules were detectable transiently in cells, peaking at the time when the class II molecules entered the MHC class II compartment. HLA-DR alpha beta dimers newly released from I chain, and those associated with I chain fragments, were found to associate with HLA-DM in vivo. Mature, peptide-loaded DR molecules also associated at a low level. These same species, but not DR-I chain complexes, were also shown to bind to purified HLA-DM molecules in vitro. HLA-DM interaction was quantitatively superior with DR molecules isolated in association with CLIP. DM-DR complexes generated by incubating HLA-DM with purified DR alpha beta CLIP contained virtually no associated CLIP, suggesting that this superior interaction reflects a prolonged HLA-DM association with empty class II dimers after CLIP dissociation. Incubation of peptide-free alpha beta dimers in the presence of HLA-DM was found to prolong their ability to bind subsequently added antigenic peptides. Stabilization of empty class II molecules may be an important property of HLA-DM in facilitating antigen processing.

  10. Guide to Choosing a Hospital

    MedlinePlus

    ... your condition? Should you consider a specialty hospital, teaching hospital (usually part of a university), community hospital, ... been approved by Medicare. Hospitals may choose either method of evaluation. You can check with a hospital ...

  11. Dr William Wilson Ingram (1888-1982): doctor-soldier, physician and Antarctic expeditioner.

    PubMed

    Pearn, J H

    2011-09-01

    Dr William Wilson Ingram (1888-1982), a Scottish-born physician, contributed significantly to the health and heritage of Australia, his adopted land. Born on Speyside and educated in Aberdeen, he was a doctor-soldier in two World Wars and decorated with the Military Cross. Ingram was a Foundation Fellow (1938) of the Royal Australasian College of Physicians and established one of the first specialist diabetic clinics in Australia, in Sydney in 1928. As an arachnologist, he published clinical descriptions of both surviving and fatal cases of envenomation by the Sydney funnel web spider, Atrax robustus. He founded the Kolling Institute of Medical Research at the Royal North Shore Hospital in Sydney where for two generations he was a leader in both undergraduate and postgraduate medical education. The international significance of his life's work relates to his service as the medical officer and biologist on the two British, Australian and New Zealand Antarctic Research Expeditions (BANZARE) of 1929-1931, for which service he was awarded the Polar Medal and subsequent Clasp. Those expeditions secured, for the British Crown, what was to become the Australian Antarctic Territory, ceded to Australia by a British Order in Council of 24 August 1936. Sir Douglas Mawson, polar expeditioner and the leader of BANZARE, described Ingram as 'an ideal medical officer', one who in addition to his clinical skills and judgement, manifested courage and 'physical endurance and a full measure of camaraderie'. Ingram has no published obituary or biography. This précis records some details of his extraordinary life.

  12. Dr. Gu Baochang speaks out on son preference in China.

    PubMed

    Bai, F

    1995-08-01

    In an interview, Dr. Gu Baochang of China discussed the topics of son preference and the increasing male-to-female sex ratio at birth in China. Gu noted that prior to 1980 the sex ratio in China was normal but that it reached a high of 113.9 in 1989 as fertility dropped. The yearly sex ratio figures continue to be close to normal for first parity births but become increasingly unbalanced for higher order births. The reasons for this abnormal sex ratio at birth are the underreporting of female births (which is estimated to account for 50-75% of the abnormality but is decreasing), sex selective abortion (which is becoming the major factor), and the lesser influence of the infanticide of female babies. The preference for sons which persists in China, Taiwan, and the Republic of Korea is determined by the issues of family labor, elderly support, women's status, and carrying on the family line. All of these issues will be influenced by socioeconomic development, which can vary in different regions of a country. Thus, Shanghai has achieved replacement level fertility with a normal sex ratio. Also, to improve efforts at fertility transition, the evaluation of family planning programs should include the incidence of son preference, and the programs should emphasize reproductive health and women's status. The issue of son preference can be explored from a broad perspective by examining the experience of other Asian countries, some of which have normal sex ratios, others of which have excess infant and child mortality. The Chinese government is trying to curb son preference by making efforts to improve the status of women and girls and by banning the illegal use of the sonogram. Eventually, as society evolves and people become achieve economic development, a normal sex ratio and low fertility will be achieved.

  13. Dr. Nicholas Ionescu-Pallas at His 70-th Anniversary

    NASA Astrophysics Data System (ADS)

    Vlad, Valentin I.

    The article is devoted to 70-th Anniversary of Dr. Nicholas Ionescu-Pallas (borne on July 30, 1932 in Pallas village close to the town of Constanţa, Romania as the son of Ion Ionescu and Maria Dincă), an outstanding Romanian physicist with contributuions in a large area of theoretical and experimental physics, from Theoretical Classical and Quantum Mechanics to General Relativity and Gravitation. He was graduated from the University of Bucharest (1955), a disciple of Professor Ion Agârbiceanu, Doctor of Physics in 1971. He is the author of more than 300 scientific papers and 3 fundamental monographs in these areas, unique in Romania, and of great international circulation. He was one of the creators of the First Romanian Laser. He was elected the Honorary President of the Romanian Society on Genereal Relativity and Gravitation. A great erudition by Ionescu-Pallas allowed him to make also contributions in History of Sciencs. He has been a member of the Academic Commitee for the Philosophy and history of science, of the European Physical Society (1971), of the European Group for Atomic spectroscopy (1970), of the Institute for Scientific Culture E. Majorana (1976), of the International Society of Gravitation and General Relativity (1978) and of the Astronomical Society of India (1982). He was a representative of the intellectuals in the Scientific Council of the Institute for Atomic Physics, 1970-1975; a member of the National Commitee for physics in 1970, and a member of the Coordinating Commitee for the Romanian Enclclopaedia of Physics in 1983. His biographical data are available in Men of Achievement, Who's Who in the World, and Short History of the Romanian Scientific and Technical Creativeness.

  14. Induction and increase of HLA-DR antigen expression by immune interferon on ML-3 cell line enhances the anti-HLA-DR immunotoxin activity.

    PubMed Central

    Chiron, M; Jaffrezou, J P; Carayon, P; Bordier, C; Roubinet, F; Xavier, C; Brandely, M; Laurent, G

    1990-01-01

    In order to evaluate the impact of induction and increase target antigen expression on immunotoxin potency, we measured the potentiating effect of recombinant immune interferon-gamma (rIFN-gamma) on the cytotoxicity of an anti HLA-DR ricin A-chain immunotoxin (2G5 RTA-IT) on the myeloid cell line ML-3. After 48 h of incubation with rIFN-gamma (500 U/ml) the percentage of 2G5-positive cells increased from 40% to 79%, and the 2G5 mean density was enhanced by 10-fold (11,000 versus 110,000 molecules/cell). Concurrently, rIFN-gamma pretreatment induced a dramatic improvement of 2G5 RTA-IT dose-effect cytotoxicity, as well as immunotoxin cytotoxicity kinetics. When 2G5 RTA-IT was used at the optimal dose of 10(-8)M (the maximum dose which avoided non-specific ricin A-chain cytotoxicity), the immunotoxin-induced cell kill increased with the percentage of DR-positive ML-3 cells according to a similar linear-logarithmic function of rIFN-gamma concentration. Moreover, in the same range of rIFN-gamma concentrations, the killing values and the percentage of DR-positive ML-3 cells were similar if not identical. These findings imply that the enhancement of 2G5 RTA-IT cytotoxicity by rIFN-gamma is mainly related to the rIFN-gamma 2G5 antigen induction on HLA-DR negative cells when immunotoxin was used at 10(-8) M. Furthermore, 2G5 RTA-IT dose-effect cytotoxicity on DR-expressing ML-3 cells, when used at lower concentrations, was also increased by rIFN-gamma in a dose-dependent manner. This result suggests that for immunotoxin concentrations close to the limiting membrane saturation dose (10(-10)M), rIFN-gamma may not solely act by inducing HLA-DR expression on DR-negative ML-3 subpopulation but also by increasing individual cellular DR density on DR expressing ML-3 cells. Finally, our study showed that immunotoxin potency on malignant cell populations which display an heterogeneous antigen expression, could be greatly improved by the use of rIFN-gamma. PMID:2122930

  15. Dr Reginald Koettlitz (1860-1916): Arctic and Antarctic explorer.

    PubMed

    Guly, Henry

    2012-11-01

    Reginald Koettlitz was born in Ostend but moved to England as a child and qualified at Guy's Hospital. He was a general practitioner in County Durham for eight years before serving as doctor and geologist to the Jackson-Harmsworth Expedition to Franz-Josef Land in 1894-97. Thereafter he made further expeditions to Somaliland, Abyssinia and the Amazon before joining Captain Scott's Discovery Expedition to the Antarctic in 1901-04 as surgeon and botanist. After the expedition he emigrated to South Africa, where he worked as a general practitioner, dying in 1916.

  16. Making sense of shadows: Dr. James Third and the introduction of x-rays, 1896 to 1902.

    PubMed Central

    Hayter, C

    1995-01-01

    The discovery of x-rays was announced by German physicist Wilhelm Conrad Röntgen in December 1895. This review of the introduction of the use of x-rays in Kingston, Ont., shows the rapidity of their adoption in Canadian medicine. By February 1896 "x-ray photographs" were being taken by Captain John Cochrane of the Royal Military College of Canada in Kingston. Initially a scientific and popular curiosity, the new rays were quickly applied to medicine, and by the fall of 1896 the Kingston General Hospital had acquired its own x-ray apparatus. The hospital superintendent, Dr. James Third, became a leading practitioner and promoter of radiographic diagnosis and radiation therapy. He published, in 1902, the first comprehensive review of the diagnostic and therapeutic uses of x-rays by a Canadian physician. Third's writings reveal his technical knowledge, his organized approach to the application of radiography to clinical medicine and his cautious attitude. Like other physicians who have witnessed the introduction of new diagnostic techniques, Third feared that the new technology would usurp the physician's clinical skills. Images p1250-a p1251-a p1252-a p1253-a PMID:7497387

  17. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles

    PubMed Central

    1993-01-01

    Naturally processed peptides were acid extracted from immunoaffinity- purified HLA-DR2, DR3, DR4, DR7, and DR8. Using the complementary techniques of mass spectrometry and Edman microsequencing, > 200 unique peptide masses were identified from each allele, ranging from 1,200 to 4,000 daltons (10-34 residues in length), and a total of 201 peptide sequences were obtained. These peptides were derived from 66 different source proteins and represented sets nested at both the amino- and carboxy-terminal ends with an average length of 15-18 amino acids. Strikingly, most of the peptides (> 85%) were derived from endogenous proteins that intersect the endocytic/class II pathway, even though class II molecules are thought to function mainly in the presentation of exogenous foreign peptide antigens. The predominant endogenous peptides were derived from major histocompatibility complex-related molecules. A few peptides derived from exogenous bovine serum proteins were also bound to every allele. Four prominent promiscuous self- peptide sets (capable of binding to multiple HLA-DR alleles) as well as 84 allele-specific peptide sets were identified. Binding experiments confirmed that the promiscuous peptides have high affinity for the binding groove of all HLA-DR alleles examined. A potential physiologic role for these endogenous self-peptides as immunomodulators of the cellular immune response is discussed. PMID:8315383

  18. Monocyte human leukocyte antigen-DR transcriptional downregulation by cortisol during septic shock.

    PubMed

    Le Tulzo, Yves; Pangault, Celine; Amiot, Laurence; Guilloux, Valérie; Tribut, Olivier; Arvieux, Cédric; Camus, Christophe; Fauchet, Renée; Thomas, Rémi; Drénou, Bernard

    2004-05-15

    Monocyte deactivation has been identified as a major factor of immunosuppression in sepsis and is associated with a loss of surface human leukocyte antigen-DR (HLA-DR) expression on circulating monocytes. Using flow cytometry, quantitative reverse transcription-polymerase chain reaction, we investigated this phenomenon in septic patients. We confirmed the early loss of monocyte HLA-DR expression in all infected patients and demonstrated that this persistent lowered expression at Day 6 correlated with severity scores, secondary infection, and death. This phenomenon occurred at a transcriptional level via a decrease in the class II transactivator A (CIITA) transcription. Furthermore, these abnormalities correlated with the high cortisol levels observed in sepsis and not with those of other putative factors such as catecholamines or interleukin-10. Finally, in vitro studies evidenced that glucocorticoids decrease HLA-DR expression at a transcriptional level via a decrease in CIITA mRNA levels, mainly by down modulating its isoforms I and III. We conclude that in human sepsis, the loss of HLA-DR expression on circulating monocytes is associated with a poor outcome. We suggest that the high endogenous cortisol level observed in septic shock may be a possible new factor involved in the loss of HLA-DR expression on monocytes via its effect on HLA-DR and CIITA transcription.

  19. The application of hospitality elements in hospitals.

    PubMed

    Wu, Ziqi; Robson, Stephani; Hollis, Brooke

    2013-01-01

    In the last decade, many hospital designs have taken inspiration from hotels, spurred by factors such as increased patient and family expectations and regulatory or financial incentives. Increasingly, research evidence suggests the value of enhancing the physical environment to foster healing and drive consumer decisions and perceptions of service quality. Although interest is increasing in the broader applicability of numerous hospitality concepts to the healthcare field, the focus of this article is design innovations, and the services that such innovations support, from the hospitality industry. To identify physical hotel design elements and associated operational features that have been used in the healthcare arena, a series of interviews with hospital and hotel design experts were conducted. Current examples and suggestions for future hospitality elements were also sought from the experts, academic journals, and news articles. Hospitality elements applied in existing hospitals that are addressed in this article include hotel-like rooms and decor; actual hotels incorporated into medical centers; hotel-quality food, room service, and dining facilities for families; welcoming lobbies and common spaces; hospitality-oriented customer service training; enhanced service offerings, including concierges; spas or therapy centers; hotel-style signage and way-finding tools; and entertainment features. Selected elements that have potential for future incorporation include executive lounges and/or communal lobbies with complimentary wireless Internet and refreshments, centralized controls for patients, and flexible furniture. Although the findings from this study underscore the need for more hospitality-like environments in hospitals, the investment decisions made by healthcare executives must be balanced with cost-effectiveness and the assurance that clinical excellence remains the top priority.

  20. The extraordinary career of Professor Dr. Simon van Creveld.

    PubMed

    Stoelinga, Paul J W; Berdon, Walter E; Cohen, M Michael

    2014-11-01

    Simon van Creveld received both the MD and PhD degrees and had a multifaceted medical and scientific education at many hospitals and research institutes in the Netherlands, Germany, and the UK. He and his wife were the first to develop insulin for the Netherlands. His major interests were in hemophilia and hemorrhagic disorders, which accounted for 87 of his publications. In 1934, van Creveld demonstrated that a dispersed protein fraction obtained from serum could reduce the clotting time of hemophilic blood. His interest in glycogen storage disease resulted in van Creveld-von Gierke disease for which van Creveld contributed four published articles. The Ellis-van Creveld syndrome, also known as chondroectodermal dysplasia, was published in 1940 and became well known to medical geneticists. During the Nazi occupation of the Netherlands, van Creveld's professorship was taken away from him because he was Jewish. His visits to hospitals of concentration camps to treat babies and give pediatric advice while wearing a Jewish Yellow Star and interacting with SS Commandants in charge, and then leaving can only be described as amazing. After the war, his professorship was returned, and in the same year as his retirement, he established a large Hemophila Treatment and Research Center now known as the Van Creveld Clinic, which celebrated its 40th anniversary in 2005.

  1. The enigmatic figure of Dr Henry Maudsley (1835-1918).

    PubMed

    Pantelidou, Maria; Demetriades, Andreas K

    2014-08-01

    In spite of his contribution to psychiatry in 19th century Britain, Henry Maudsley remains a mysterious figure, a man mostly known for his donation to the London County Council for the building of the Maudsley Hospital and for The Maudsley Annual Lecture created in honour of his benevolence. Besides Sir Aubrey Lewis' article in 1951 and Michael Collie's attempt in 1988 to construct a biographical study on Maudsley, there does not seem to be any current endeavour to tell the story of his life, whereas Trevor Turner's contribution to the 2004 Oxford Dictionary of National Biography gives a somewhat scathing but unattributed account of Maudsley's personality. This essay attempts to explore his contributions to the Medico-Psychological Association (MPA), the current Royal College of Psychiatrists, his editorship of the Journal of Mental Health (currently named the British Journal of Psychiatry), his literary contributions and his vision for a psychiatric hospital. This essay is an attempt to demystify his figure and to explore some of the rumours and criticisms surrounding his name and the reasons why so little has been written about him. It is also a venture to unravel his complex personality and his intricate philosophy.

  2. Lymphocyte responses to DR1/4 restricted peptides in rheumatoid arthritis.

    PubMed Central

    Skinner, M A; Watson, L; Geursen, A; Tan, P L

    1994-01-01

    OBJECTIVE--To determine whether analog and unrelated DR1/4 binding peptides alter DR1/4 restricted responses of peripheral blood lymphocytes (PBL) from patients with rheumatoid arthritis (RA). METHODS--PBL from 25 patients with RA and 12 healthy controls were cultured with DR1/4 restricted peptides of the influenza haemagglutinin, amino acids 307-319 (HA) and matrix proteins, amino acids 17-29 (IM). Responses were determined by 3H-thymidine uptake proliferation assays and limiting dilution analysis. Competitor peptides were analogs HA-R312 and HA-K313 differing from HA by one amino acid at the 312 or 313 position respectively or unrelated peptides which bind to DR1/4. RESULTS--The responses of eight patients with RA to the two stimulatory influenza peptides did not differ significantly from controls and this was confirmed by the frequency estimate of T cells in PBL which responded to HA (mean frequency: 1 in 9.0 x 10(4), n = 5, in DR1/4+ RA patients, 1 in 7.6 x 10(4), n = 5, in DR1/4+ healthy controls). DR1/4 binding analogs of the HA peptide inhibited HA specific peptide responses of PBL from patients with RA and controls. Inhibition was also detected with unrelated peptides which bind to DR1/4 but to which the individual did not respond. CONCLUSION--Similar responses to two DR1/4 restricted peptides were observed in patients with RA and controls. Both antigen analog- and unrelated peptide-major histocompatibility complexes (MHC) can result in the inhibition of antigen specific responses in multi-clonal human lymphocyte populations. However, an analog peptide may be stimulatory in some individuals. These results provide some initial data for the development of a rational approach to MHC-specific immunomodulation in rheumatoid arthritis. Images PMID:8154934

  3. Dose reduction using prior image constrained compressed sensing (DR-PICCS)

    NASA Astrophysics Data System (ADS)

    Tang, Jie; Thériault Lauzier, Pascal; Chen, Guang-Hong

    2011-03-01

    A technique for dose reduction using prior image constrained compressed sensing (DR-PICCS) in computed tomography (CT) is proposed in this work. In DR-PICCS, a standard FBP reconstructed image is forward projected to get a fully sampled projection data set. Meanwhile, it is low-pass filtered and used as the prior image in the PICCS reconstruction framework. Next, the prior image and the forward projection data are used together by the PICCS algorithm to obtain a low noise DR-PICCS reconstruction, which maintains the spatial resolution of the original FBP images. The spatial resolution of DR-PICCS was studied using a Catphan phantom by MTF measurement. The noise reduction factor, CT number change and noise texture were studied using human subject data consisting of 20 CT colonography exams performed under an IRB-approved protocol. In each human subject study, six ROIs (two soft tissue, two colonic air columns, and two subcutaneous fat) were selected for the CT number and noise measurements study. Skewness and kurtosis were used as figures of merit to indicate the noise texture. A Bland-Altman analysis was performed to study the accuracy of the CT number. The results showed that, compared with FBP reconstructions, the MTF curve shows very little change in DR-PICCS reconstructions, spatial resolution loss is less than 0.1 lp/cm, and the noise standard deviation can be reduced by a factor of 3 with DR-PICCS. The CT numbers in FBP and DR-PICCS reconstructions agree well, which indicates that DR-PICCS does not change CT numbers. The noise textures indicators measured from DR-PICCS images are in a similar range as FBP images.

  4. Enhancing Anti-Breast Cancer Immunity by Blocking Death Receptor DR5

    DTIC Science & Technology

    2010-09-01

    as a self antigen. Therefore, we have developed a transgenic hDR5 mouse strain in which phDR5 is driven by whey acidic protein promoter. Founder...a head and neck tumor. All three constructs express human DR5 protein in transfected cells as judged by flow analysis with mAb A631 to the...were treated with 100 ng/ml TRAIL for 48 h as described in (A). Total protein was extracted for assaying total and phosphorylated Akt (p-AKT), PTEN

  5. Dr. Ray Gause examines student Skylab experiment ED-52 Web Formation

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Dr. Ray Gause of the NASA-Marshall Space Flight Center (MSFC) places dinner, in the form of a housefly, in the web of Arabella - the prime spider for the ED-52 Web Formation Experiment. Arabella can be delineated near the end of the black pen in Dr. Gause's hand. The experiment is one of 25 student experiments accepted for the Skylab program and will be performed during the Skylab 3 mission. Judy Miles, a 17-year-old high school student from Lexington, Massachusetts, is the student experimenter and Dr. Gause is the NASA student advisor.

  6. Treating children with affect dysregulation. Discussion of Dr. Wendy Olesker's analysis of Matt.

    PubMed

    Yanof, Judith A

    2012-01-01

    This paper is a discussion of Dr. Wendy Olesker's sensitive analytic treatment of an impulsive, affectively dysregulated, preschool child. Drawing on her knowledge and understanding of developmental interference, trauma, and conflict, Dr. Olesker uses a variety of nonverbal, interpretative, developmental, and play techniques during the analysis to help this boy progress in his development. She also works with the parents collaboratively as part of the therapeutic process. Because Dr. Olesker's description of Matt might easily fit a diagnosis of Attention Deficit Hyperactivity Disorder, it is suggested that child analysts recognize the usefulness of considering child analysis when they are evaluating or treating children with this diagnosis.

  7. Dr. John Frederick May and the identification of John Wilkes Booth's body.

    PubMed

    Spiegel, A D

    1998-10-01

    Shortly after President Abraham Lincoln's assassin was killed on April 26, 1865, a formal inquest was held to positively identify the body. Dr. John Frederick May, a leading surgeon in the District of Columbia, was summoned to examine the remains. Two years earlier, Dr. May had removed a fibroid tumor from the back of the assassin's neck and an identifiable large ugly scar resulted when the wound inadvertently opened and healed by granulation. Based upon the recognition of the scar made by his scalpel, Dr. May made a positive identification.

  8. Help prevent hospital errors

    MedlinePlus

    ... www.ncbi.nlm.nih.gov/pubmed/23330698 . The Joint Commission. Hospital: 2014 National Patient Safety Goals. www.jointcommission. ... October 24, 2014. Accessed October 27, 2016. The Joint Commission. Hospital: 2016 National Patient Safety Goals. Updated January ...

  9. Hospitals as health educators

    MedlinePlus

    ... than your local hospital. From health videos to yoga classes, many hospitals offer information families need to ... care and breastfeeding Parenting Baby sign language Baby yoga or massage Babysitting courses for teens Exercise classes ...

  10. Surviving Your Child's Hospitalization.

    ERIC Educational Resources Information Center

    Cohen, David A.

    1988-01-01

    The parent of a young child who required major open heart surgery shares his suggestions for coping with a young child's hospitalization including parent visitation, relating to the hospital staff, getting answers to questions, and utilizing available services. (DB)

  11. Implementing Total Quality Leadership within Naval Hospital Camp Pendleton Using the Fourteen Points of Dr. Deming’s Philosophy

    DTIC Science & Technology

    1991-12-01

    Berwick, 1989; Merry, 1990). Today, the health care consumer is sophisticated, demanding, and more educated than ever before. This new consumer has...and foundation for the cultural change; delineate the educational requirements necessary for full adoption; and specify the long range strategic course...is changing. The consumers of healthcare today are far more educated in healthcare and have expectations of the manner and type of care they will

  12. [Historical origins between National Medical Association of China and Boji Hospital in Guangzhou].

    PubMed

    Liu, Pinming

    2015-09-01

    In 2015, National Medical Association of China, now being called the Chinese Medical Association, celebrates its centennial and Boji Hospital in Guangzhou ( also known as Canton Hospital, or the Canton Pok Tsai Hospital, and now Sun Yat-sen Memorial Hospital of Sun Yat-sen University ) marks its 180th anniversary. Three major historical events establish the role of Boji Hospital in the founding and development of the National Medical Association of China during the last 100 years, viz.: ①hosting and participating in the establishment of the Medical Missionary Association of China and its official journal: the China Medical Missionary Journal; ②holding the 11th scientific sessions of the National Medical Association of China; ③nominating Dr. Wu Lien-teh as a candidate for the Nobel Prize in Physiology or Medicine in 1935 by William Warder Cadbury, the president of Boji Hospital.

  13. Hospital materials managers need to be aware of actions that constitute legal acceptance.

    PubMed

    Decker, R

    1990-12-01

    A hospital invited bids for building materials for a hospital construction project. A supplier submitted a bid which asked the hospital to sign and return a trade association form contract. The hospital didn't return the form but used the supplier's bid as part of the general contract for the entire project and notified the supplier and the general contractor. Later, the supplier submitted a higher bid for the same material contending that the hospital hadn't accepted the first bid as they hadn't followed the instructions. The hospital materials manager feels that the bid was properly accepted. In this dialogue, Dr. Decker reviews the legal issues involved in the different ways of accepting an offer.

  14. Hospital Dermatology, Introduction.

    PubMed

    Fox, Lindy P

    2017-03-01

    Inpatient dermatology is emerging as a distinct dermatology subspecialty where dermatologists specialize in caring for patients hospitalized with skin disease. While the main focus of inpatient dermatology is the delivery of top-quality and timely dermatologic care to patients in the hospital setting, the practice of hospital-based dermatology has many additional components that are critical to its success.

  15. Gamification of Clinical Routine: The Dr. Fill Approach.

    PubMed

    Bukowski, Mark; Kühn, Martin; Zhao, Xiaoqing; Bettermann, Ralf; Jonas, Stephan

    2016-01-01

    Gamification is used in clinical context in the health care education. Furthermore, it has shown great promises to improve the performance of the health care staff in their daily routine. In this work we focus on the medication sorting task, which is performed manually in hospitals. This task is very error prone and needs to be performed daily. Nevertheless, errors in the medication are crucial and lead to serious complications. In this work we present a real world gamification approach of the medication sorting task in a patient's daily pill organizer. The player of the game needs to sort the correct medication into the correct dispenser slots and is rewarded or punished in real time. At the end of the game, a score is given and the user can register in a leaderboard.

  16. Individual effects of the DR11-variable beta-chain residues 67, 71, and 86 upon DR(alpha,beta 1*1101)-restricted, peptide-specific T cell proliferation.

    PubMed

    McKinney, J S; Fu, X T; Swearingen, C; Klohe, E; Karr, R W

    1994-12-15

    The four members of the HLA-DR11 family of class II molecules vary only by three or fewer amino acids via dimorphisms among DR beta-chain residues 67, 71, and 86. However, they differ markedly in their abilities to induce proliferation of DR(alpha,beta 1*1101)-restricted, peptide-specific T cell clones. To dissect which DR11-variable residues, individually and in combination, mediate these functional differences, we used as APC transfectants expressing DR molecules with one of all possible permutations of DR11-variable sequences, including the four DR11 family members, and four additional DR11 variant mutants. The abilities of the wild-type or mutant molecules to present two distinct influenza peptide Ags, HA307-19 and HA128-45, to T cells was assessed in in vitro T cell proliferation assays. Of the naturally dimorphic DR11 positions, residue beta 71 variation significantly influenced the ability of DR11 molecules to present both peptides to DR(alpha,beta 1*1101)-restricted T cells. Residue beta 86 variation had relatively less influence than reported in several other DR and peptide systems. Residue beta 67 variation usually appeared irrelevant to T cell proliferation, but in two mutants led to unexpected T cell proliferation independent of nominal peptide Ag. Peptide binding, assessed by flow cytometry, was not found to be altered by any mutations that disrupted DR(alpha,beta 1*1101)-like presentation. These data indicate that residue beta 71 exerts a central role in influencing the functional differences among DR11 molecules, whereas the widely studied dimorphism of residue beta 86 is not as generally influential in DR11 as in other alleles.

  17. High Blood Cholesterol Q&A Dr. Michael Lauer | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. Feature: High Cholesterol High Blood Cholesterol Q&A with Dr. Michael Lauer Past Issues / ... heavier and older, what does recent research on cholesterol and heart health tell us that Americans need ...

  18. New NIH Director Dr. Francis Collins on Medical Research That Benefits Everyone's Health

    MedlinePlus

    ... version of this page please turn Javascript on. New NIH Director Dr. Francis Collins on Medical Research ... Our goal is to advance biomedical research in new, innovative ways that will benefit everyone's health." — NIH ...

  19. Detection of HLA-D/DR-related DNA polymorphism in HLA-D homozygous typing cells.

    PubMed Central

    Owerbach, D; Lernmark, A; Rask, L; Peterson, P A; Platz, P; Svejgaard, A

    1983-01-01

    Sequences of different sizes are generated when DNA from homozygous HLA-Dw/DR typing cells are digested with restriction endonuclease and analyzed by hybridization with a HLA-D region class II antigen beta-chain cDNA probe. The patterns of hybridization were highly polymorphic but one endonuclease, BamHI, defined sequences unique to all HLA-Dw/DR specificities 1-8 except HLA-Dw/DR 2 and 6; however, these two specificities were resolved with the enzyme EcoRI. Digestion with other endonucleases such as Pst I results in patterns of restriction fragments that differ between homozygous typing cells of the same HLA-Dw/DR specificity. HLA-D region beta-chain probes permit HLA-D region genotyping at the DNA level and may allow detection of genes controlling the association of HLA specificities with a wide variety of diseases. Images PMID:6304735

  20. VISIT TO DR SHARP - BEN PINKEL - ABE SILVERSTEIN - OSCAR SCHEY - JESSE HALL - JOHN COLLINS BY CONGRE

    NASA Technical Reports Server (NTRS)

    1949-01-01

    VISIT TO DR SHARP - BEN PINKEL - ABE SILVERSTEIN - OSCAR SCHEY - JESSE HALL - JOHN COLLINS BY CONGRESSMAN CARL HENSHAW FROM CALIFORNIA - NORWICK ROSS DEPARTMENT OF COMMERCE - SENOR BUCH DE PERADA REPRESENTATIVE FROM MEXICO -

  1. Dr Mary Crosse, OBE, MD (1900–1972) and the premature baby

    PubMed Central

    Dunn, P M

    2007-01-01

    On behalf of Birmingham's Department of Public Health, Dr Crosse developed the Sorrento Premature Baby Unit in 1931 and pioneered the modern care of these small newborn infants in Britain. PMID:17337665

  2. Description of work for 100-DR-2 Operable Unit Vadose Drilling/test pits

    SciTech Connect

    Naiknimbalkar, N.

    1993-08-01

    This report describes the scope of work for the boreholes/test pits of the 100-DR-2 Operable Unit. Sampling and field activities include: Soil screening; geologic sampling; soil sampling (physical property); analytical sampling and depths; and geophysical logging.

  3. Interview with ARPA-E Acting Director Dr. Cheryl Martin on Platts Energy Week

    ScienceCinema

    Martin, Cheryl; Loveless, Bill

    2016-07-12

    Bill Loveless from Platts Energy Week interviews ARPA-E Acting Director, Dr. Cheryl Martin, about the many transformational energy technologies on display at ARPA-E's 5th annual Energy Innovation Summit.

  4. Science Matters Podcast: Questions and Answers with EPA's Dr. Peter Grevatt

    EPA Pesticide Factsheets

    Listen to a podcast with Dr. Peter Grevatt, the director of EPA's Office of Children's Health Protection, as he answers questions about children's health, or read some of the highlights from the conversation here.

  5. Dr. Grant Heikan examines lunar material in sieve from sample container

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Grant Heikan, Manned Spacecraft Center and a Lunar Sample preliminary Examination Team member, examines lunar material in a sieve from the bulk sample container which was opened in the Biopreparation Laboratory of the Lunar Receiving Laboratory.

  6. Interview with ARPA-E Acting Director Dr. Cheryl Martin on Platts Energy Week

    SciTech Connect

    Martin, Cheryl; Loveless, Bill

    2014-03-18

    Bill Loveless from Platts Energy Week interviews ARPA-E Acting Director, Dr. Cheryl Martin, about the many transformational energy technologies on display at ARPA-E's 5th annual Energy Innovation Summit.

  7. Dr. Michael DeBakey "is a magician of the heart…"

    MedlinePlus

    ... NLM's David Nash and admiring students from the Michael E. DeBakey High School for Health Professionals in Houston, ... pump to assist a patient's damaged heart. Dr. Michael E. DeBakey, shown with his surgical team in the ...

  8. Eye-Eye with Dr. Rachel Bishop | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn JavaScript on. Feature: Glaucoma Eye-to-Eye with Dr. Rachel Bishop Past Issues / Spring 2015 ... new patient comes in because they scratched their eye while working in the yard, or they think ...

  9. ISS Update: Dr. Steve Squyres, NEEMO 16 Aquanaut and Cornell Professor

    NASA Video Gallery

    ISS Update Commentator Pat Ryan interviews Dr. Steve Squyres, NEEMO 16 Aquanaut and Cornell Professor, about simulating a mission to an asteroid underwater. The Aquarius habitat simulates the isola...

  10. Dr. Louis Sullivan: Treating America's Most Critical Health and Human Services Ills.

    ERIC Educational Resources Information Center

    Cox, William E,; Matthews, Frank L.

    1989-01-01

    Interview with Dr. Louis Sullivan, Secretary of Health and Human Services. Discusses his views on health education, budget, access to health care, minority health, abortion, infant mortality, drugs, the Head Start Program, federal planning effects, and family influences. (JS)

  11. Meet EPA Exposure Scientist and National Program Director Dr. Tina Bahadori

    EPA Pesticide Factsheets

    Dr. Tina Bahadori leads EPA's Chemical Safety for Sustainability research program. She is an exposure scientist with extensive expertise developing and managing research programs that integrate exposure with health sciences.

  12. Ask Dr. Sue--Updates: Infectious Diseases, SIDS, HIV/AIDS.

    ERIC Educational Resources Information Center

    Aronson, Susan S.

    1995-01-01

    Describes new concerns about infectious diseases in childcare settings (tuberculosis, gastrointestinal infections, and lice); sleep position and SIDS; HIV/AIDS issues; and the use of sterilized sand in sand boxes. (DR)

  13. Positioning hospitals: a model for regional hospitals.

    PubMed

    Reddy, A C; Campbell, D P

    1993-01-01

    In an age of marketing warfare in the health care industry, hospitals need creative strategies to compete successfully. Lately, positioning concepts have been added to the health care marketer's arsenal of strategies. To blend theory with practice, the authors review basic positioning theory and present a framework for developing positioning strategies. They also evaluate the marketing strategies of a regional hospital to provide a case example.

  14. VizieR Online Data Catalog: Gaia DR1 (Gaia Collaboration, 2016)

    NASA Astrophysics Data System (ADS)

    Gaia Collaboration

    2016-06-01

    Gaia DR1 is based on observations collected between 25 July 2014 and 16 September 2015. Gaia DR1 contains positions (RA,DE) and G magnitudes for all sources with acceptable formal standard errors on positions. Positions and individual uncertainties are computed using a generic prior and Bayes' rule (detailed description in "Gaia astrometry for stars with too few observations. A Bayesian approach", Michalik et al., 2015A&A...583A..68M). The five-parameter astrometric solution - positions, parallaxes, and proper motions - for stars in common between the Tycho-2 Catalogue and Gaia is contained in Gaia DR1. This part of Gaia DR1 is based on the Tycho-Gaia Astrometric Solution (paper with detailed description (Michalik et al., 2015A&A...574A.115M); paper describing theory and background (Michalik et al., 2014A&A...571A..85M); paper describing quasar extension (Michalik & Lindegren, 2016A&A...586A..26M)). At the beginning of the routine phase, for a period of 4 weeks, a special scanning mode repeatedly covering the ecliptic poles on every spin was executed for calibration purposes. Photometric data of selected RR Lyrae and Cepheid variable stars based on these high-cadence measurements are contained in Gaia DR1. Positions (RA,DE) and G magnitudes for 2152 ICRF quasars (F. Mignard et al., 2016, A&A, in press.). The Gaia Archive DR1 data is available at archives.esac.esa.int/gaia. Tgas and Gaia Sources can be downloaded as VOTables, FITS or CSV at http://1016243957.rsc.cdn77.org/Gaia/ If you use public Gaia DR1 data in your paper, please take note of our guide on how to acknowledge and cite Gaia DR1: http://gaia.esac.esa.int/documentation/GDR1/Miscellaneous/\\ seccreditandcitationinstructions.html (9 data files).

  15. Early artificial ventilation: the mystery of "Truehead of Galveston"--was he Dr Charles William Trueheart?

    PubMed

    Trubuhovich, Ronald V

    2008-12-01

    It seems strange that the medical literature from the United States has only a single original source of reference for a device (from circa 1870) for artificial ventilation in neonatal resuscitation. The invention is attributed to "Dr Truehead of Galveston, Texas". I argue that this mystery arises from two separate misspellings of the inventor's name, and propose that the correct name is Dr Charles William Trueheart (1837-1914), also of Galveston.

  16. Dr. Norman Thagard, crewmember for STS-7, during training on the KC-135

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Dr. Norman E. Thagard, a physician assigned to mission specialist duties on STS-7, familiarizes himself with the donning and doffing of the extravehicular mobility unit (EMU) onboard NASA's zero gravity aircraft, the KC-135. In this view, Dr. Thagard is assisted by various technicians to don the EMU. He is wearing the hard upper and lower torso, but not the backpack, gloves or helmet.

  17. Laryngology in Art: The Portrait of Dr Wilhelm Mayer-Hermann.

    PubMed

    Patel, Amit A

    2016-12-01

    Otto Dix's portrait of the laryngologist Dr Wilhelm Mayer-Hermann represents a shining example of Neue Sachlichkeit, or New Objectivity, offering a return to unsentimental reality and a focus on the objective world, as opposed to the more abstract and idealistic tendencies of expressionism. However, precious little is known about the subject of the portrait. This article examines the portrait and attempts to shed light on the life and career of the Dr Wilhelm Mayer-Hermann.

  18. Nitrosylcobalamin Promotes Cell Death via S Nitrosylation of Apo2L/TRAIL Receptor DR4

    PubMed Central

    Tang, Zhuo; Bauer, Joseph A.; Morrison, Bei; Lindner, Daniel J.

    2006-01-01

    We have previously demonstrated that nitrosylcobalamin (NO-Cbl), an analogue of vitamin B12 that delivers nitric oxide (NO), had potent antiproliferative activity against several human cancer cell lines. NO-Cbl induced apoptosis via a death receptor/caspase-8 pathway. In this study, we demonstrate that a functional Apo2L/TRAIL receptor was necessary for the induction of cell death by NO-Cbl. Furthermore, the Apo2L/TRAIL death receptor DR4 (TRAIL R1) was S nitrosylated following NO-Cbl treatment. Human melanoma (A375), renal carcinoma (ACHN), and ovarian carcinoma (NIH-OVCAR-3) cells were treated with NO-Cbl and subjected to the biotin switch assay; S-nitrosylated DR4 was detected in all three cell lines. NO-Cbl treatment did not cause S nitrosylation of DR5. The seven cysteine residues located in the cytoplasmic domain of DR4 were individually point mutated to alanines. NIH-OVCAR-3 cells expressing the DR4 C336A mutation lacked S nitrosylation following NO-Cbl treatment. Overexpression of wild-type DR4 sensitized cells to growth inhibition by NO-Cbl. Cells expressing the DR4 C336A mutant were more resistant to NO-Cbl and Apo2L/TRAIL than were the other six C-A mutations or wild-type cells. The C336A mutant also displayed blunted caspase-8 enzymatic activity following NO-Cbl treatment compared to the other mutants. Thus, DR4 residue C336 becomes S nitrosylated and promotes apoptosis following NO-Cbl treatment. PMID:16847314

  19. Nanomolecular HLA-DR10 antibody mimics: A potent system for molecular targeted therapy and imaging.

    PubMed

    DeNardo, Gerald L; Natarajan, Arutselvan; Hok, Saphon; Mirick, Gary; DeNardo, Sally J; Corzett, Michele; Sysko, Vladimir; Lehmann, Joerg; Beckett, Laurel; Balhorn, Rod

    2008-12-01

    To mimic the molecular specificity and cell selectivity of monoclonal antibody (mAb) binding while decreasing size, nanomolecules (selective high-affinity ligands; SHALs), based on in silico modeling, have been created to bind to human leukocyte antigen-DR (HLA-DR10), a signaling receptor protein upregulated on the malignant B-lymphocytes of non-Hodgkin's lymphoma and chronic lymphocytic leukemia. SHALs were synthesized with a biotin or DOTA chelate (1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid), using a solid-phase lysine-polyethyleneglycol backbone to link sets of ligands shown previously to bind to HLA-DR10. Using cell-binding and death assays and confocal microscopy, SHAL uptake, residualization, and cytocidal activity were evaluated in HLA-DR10 expressing and nonexpressing live, human lymphoma cell lines. All of the SHALs tested were selective for, and accumulated in, expressing cells. Reflecting binding to HLA-DR10 inside the cells, SHALs having the Ct ligand (3-(2-([3-chloro-5-trifluoromethyl)-2-pyridinyl]oxy)-anilino)-3-oxopropanionic acid) residualized in expressing cells greater than 179 times more than accountable by cell-surface membrane HLA-DR10. Confocal microscopy confirmed the intracellular residualization of these SHALs. Importantly, SHALs with a Ct ligand had direct cytocidal activity, similar in potency to that of Lym-1 mAb and rituximab, selectively for HLA-DR10 expressing lymphoma cells and xenografts. The results show that SHALs containing the Ct ligand residualize intracellularly and have cytocidal effects mediated by HLA-DR10. These SHALs have extraordinary potential as novel molecules for the selective targeting of lymphoma and leukemia for molecular therapy and imaging. Further, these SHALs can be used to transport and residualize cytotoxic agents near critical sites inside these malignant cells.

  20. Dr John Dickinson (1832-1863): The man behind the bird.

    PubMed

    Conacher, I D

    2016-08-01

    The surgeon/naturalists Dr John Kirk, Dr Charles Meller and Dr John Dickinson, associated with the Zambezi Expedition (1857-1864) under the leadership of Dr David Livingstone are, like him, credited with the discovery of new species' of birds. A raptor, Falco dickinsoni, is named after Dr John Dickinson. Dickinson, born in the north east of England, trained in medicine in Newcastle upon Tyne. He volunteered to join the Universities' Mission to Central Africa and arrived as part of a second group to join Bishop Frederick Mackenzie, then attempting to build a Mission in Magomero, on the Shire Mountain Plateau in modern Malawi. Livingstone and Mackenzie had sown the seeds of disaster for the first UMCA venture while Dickinson was on his way to Central Africa, and his one meeting with Livingstone was trigger to a chain of events that threatened the whole expedition. Shortly after Dickinson's arrival in Magomero, Bishop Mackenzie and a fellow traveller, Reverend Henry de Wint Burrup, died. Magomero was abandoned and the remaining missionaries retrenched in Chibisa's Village on the River Shire. There, where Dickinson did most of his bird collecting, on 17 March 1863, he died of blackwater fever. Livingstone and Kirk were present at the burial. A marble cross at Chikwawa in Malawi is marker to the event that occurred on the day of Dr John Dickinson's 32nd birthday.

  1. The structure of HLA-DR52c: Comparison to other HLA-DRB3 alleles

    SciTech Connect

    Dai, Shaodong; Crawford, Frances; Marrack, Philippa; Kappler, John W.

    2008-09-05

    Class II major histocompatibility complex (MHCII) molecules present antigens to CD4{sup +} T cells. In addition to the most commonly studied human MHCII isotype, HLA-DR, whose {beta} chain is encoded by the HLA-DRB1 locus, several other isotypes that use the same {alpha} chain but have {beta} chains encoded by other genes. These other DR molecules also are expressed in antigen-presenting cells and are known to participate in peptide presentation to T cells and to be recognized as alloantigens by other T cells. Like some of the HLA-DRB1 alleles, several of these alternate DR molecules have been associated with specific autoimmune diseases and T cell hypersensitivity. Here we present the structure of an HLA-DR molecule (DR52c) containing one of these alternate {beta} chains (HLA-DRB3*0301) bound to a self-peptide derived from the Tu elongation factor. The molecule shares structurally conserved elements with other MHC class II molecules but has some unique features in the peptide-binding groove. Comparison of the three major HLA-DBR3 alleles (DR52a, b, and c) suggests that they were derived from one another by recombination events that scrambled the four major peptide-binding pockets at peptide positions 1, 4, 6, and 9 but left virtually no polymorphisms elsewhere in the molecules.

  2. DR3 regulation of apoptosis of naive T-lymphocytes in children with acute infectious mononucleosis.

    PubMed

    Filatova, Elena Nikolaevna; Anisenkova, Elena Viktorovna; Presnyakova, Nataliya Borisovna; Utkin, Oleg Vladimirovich

    2016-09-01

    Acute infectious mononucleosis (AIM) is a widespread viral disease that mostly affects children. Development of AIM is accompanied by a change in the ratio of immune cells. This is provided by means of different biological processes including the regulation of apoptosis of naive T-cells. One of the potential regulators of apoptosis of T-lymphocytes is a death receptor 3 (DR3). We have studied the role of DR3 in the regulation of apoptosis of naive CD4(+) (nTh) and CD8(+) (nCTL) T-cells in healthy children and children with AIM. In healthy children as well as in children with AIM, the activation of DR3 is accompanied by inhibition of apoptosis of nTh. In healthy children, the stimulation of DR3 resulted in the increase in apoptosis of nCTL. On the contrary, in children with AIM, the level of apoptosis of nCTL decreased after DR3 activation, which is a positive contribution to the antiviral immune response. In children with AIM, nCTL are characterized by reduced level of apoptosis as compared with healthy children. These results indicate that DR3 can be involved in the reduction of sensitivity of nCTL to apoptosis in children with AIM.

  3. Limited field investigation report for the 100-DR-1 Operable Unit

    SciTech Connect

    Not Available

    1994-06-01

    This limited field investigation (LFI) report summarizes the data collection and analysis activities conducted during the 100-DR-1 Source Operable Unite LFI and the associated qualitative risk assessment (QRA), and makes recommendations on the continued candidacy of high-priority sites for interim remedial measures (IRM). The results and recommendations presented in this report are generally independent of future land use scenarios. The 100-DR-1 Operable Unit is one of four operable units associated with the 100 D/DR Area at the Hanford Site. The 100-DR-1 Operable Unit encompasses approximately 1.5 km{sup 2} (0.59 mi{sup 2}) and is located immediately adjacent to the Columbia River shoreline. In general, it contains waste facilities associated with the original plant facilities constructed to support D Reactor facilities, as well as cooling water retention basin systems for both D and DR Reactors. The 100-DR-1 LFI began the investigative phase of the remedial investigation for a select number of high-priority sites. The LFI was performed to provide additional data needed to support selection, design and implementation of IRM, if needed. The LFI included data compilation, nonintrusive investigations, intrusive investigations, summarization of 100 Area aggregate studies, and data evaluation.

  4. Contributions of Dr. George Washington Carver to global food security: historical reflections of Dr. Carver’s fungal plant disease survey in the southeastern United States

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dr. George Washington Carver was a world renowned scientist whose research in the agricultural sciences in the late 1800’s and early 1900’s was critical for improving the living standards of American farmers especially in the southern United States. Although best known for developing the many uses o...

  5. Redundancy in Antigen-Presenting Function of the HLA-DR and -DQ Molecules in the Multiple Sclerosis-Associated HLA-DR2 Haplotype1

    PubMed Central

    Sospedra, Mireia; Muraro, Paolo A.; Stefanová, Irena; Zhao, Yingdong; Chung, Katherine; Li, Yili; Giulianotti, Marc; Simon, Richard; Mariuzza, Roy; Pinilla, Clemencia; Martin, Roland

    2009-01-01

    The three HLA class II alleles of the DR2 haplotype, DRB1*1501, DRB5*0101, and DQB1*0602, are in strong linkage disequilibrium and confer most of the genetic risk to multiple sclerosis. Functional redundancy in Ag presentation by these class II molecules would allow recognition by a single TCR of identical peptides with the different restriction elements, facilitating T cell activation and providing one explanation how a disease-associated HLA haplotype could be linked to a CD4+ T cell-mediated autoimmune disease. Using combinatorial peptide libraries and B cell lines expressing single HLA-DR/DQ molecules, we show that two of five in vivo-expanded and likely disease-relevant, cross-reactive cerebrospinal fluid-infiltrating T cell clones use multiple disease-associated HLA class II molecules as restriction elements. One of these T cell clones recognizes >30 identical foreign and human peptides using all DR and DQ molecules of the multiple sclerosis-associated DR2 haplotype. A T cell signaling machinery tuned for efficient responses to weak ligands together with structural features of the TCR-HLA/peptide complex result in this promiscuous HLA class II restriction. PMID:16424227

  6. High Temperature Superconductors: From Delivery to Applications (Presentation from 2011 Ernest Orlando Lawrence Award-winner, Dr. Amit Goyal, and including introduction by Energy Secretary, Dr. Steven Chu)

    ScienceCinema

    Goyal, Amit (Oak Ridge National Laboratory)

    2016-07-12

    Dr. Amit Goyal, a high temperature superconductivity (HTS) researcher at Oak Ridge National Laboratory, was named a 2011 winner of the Department of Energy's Ernest Orlando Lawrence Award honoring U.S. scientists and engineers for exceptional contributions in research and development supporting DOE and its mission. Winner of the award in the inaugural category of Energy Science and Innovation, Dr. Goyal was cited for his work in 'pioneering research and transformative contributions to the field of applied high temperature superconductivity, including fundamental materials science advances and technical innovations enabling large-scale applications of these novel materials.' Following his basic research in grain-to-grain supercurrent transport, Dr. Goyal focused his energy in transitioning this fundamental understanding into cutting-edge technologies. Under OE sponsorship, Dr. Goyal co-invented the Rolling Assisted Bi-Axially Textured Substrate technology (RABiTS) that is used as a substrate for second generation HTS wires. OE support also led to the invention of Structural Single Crystal Faceted Fiber Substrate (SSIFFS) and the 3-D Self Assembly of Nanodot Columns. These inventions and associated R&D resulted in 7 R&D 100 Awards including the 2010 R&D Magazine's Innovator of the Year Award, 3 Federal Laboratory Consortium Excellence in Technology Transfer National Awards, a DOE Energy100 Award and many others. As a world authority on HTS materials, Dr. Goyal has presented OE-sponsored results in more than 150 invited talks, co-authored more than 350 papers and is a fellow of 7 professional societies.

  7. Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNA.

    PubMed

    Piechocki, Marie P; Wu, Gen Sheng; Jones, Richard F; Jacob, Jennifer B; Gibson, Heather; Ethier, Stephen P; Abrams, Judith; Yagita, Hideo; Venuprasad, K; Wei, Wei-Zen

    2012-12-01

    TNF-related apoptosis-inducing ligand receptor 2 [TRAIL-R2 or death receptor 5 (DR5)] is expressed at elevated levels in a broad range of solid tumors to mediate apoptotic signals from TRAIL or agonist antibodies. We tested the hypothesis that DR5 DNA vaccination will induce proapoptotic antibody to trigger apoptosis of tumor cells. BALB/c mice were electrovaccinated with DNA-encoding wild-type human DR5 (phDR5) or its derivatives. Resulting immune serum or purified immune IgG induced apoptosis in triple-negative breast cancer (TNBC) cells, which were also TRAIL sensitive. The proapoptotic activity of immune serum at dilutions of 0.5-2% was comparable to that of 1-2 μg/ml of TRAIL. Apoptotic activity of immune serum was enhanced by antibody crosslinking. Apoptotic cell death induced by anti-DR5 antibody was shown by the cleavage of PARP and caspase-3. In contrast, immune serum had no effect on the proliferation of activated human T cells, which expressed low levels of DR5. In vivo, hDR5 reactive immune serum prevented growth of SUM159 TNBC cells in severe combined immune-deficient mice. DR5-specific IFN-γ-secreting T cells were also induced by DNA vaccination. Furthermore, the feasibility to overcome immune tolerance to self DR5 was shown by the induction of mouse DR5-binding antibody after electrovaccination of BALB/c mice with pmDR5ectm-Td1 encoding a fusion protein of mouse DR5 and an immunogenic fragment of tetanus toxin. These findings support DR5 as a promising vaccine target for controlling TNBC and other DR5-positive cancers.

  8. A Failed Utopia in Marcela Del Río's "Proceso a Faubritten"

    ERIC Educational Resources Information Center

    Manickam, Samuel

    2014-01-01

    In Marcela del Río's science fiction novel "Proceso a Faubritten," utopia comes in the form of eternal life for all of humanity, thanks to Dr. Alexander Faubritten's "Bomba L." This polyphonic work includes diaries by Faubritten and his Mexican lover, María Corona. In my analysis of these two diaries, I will show how…

  9. [The Hospital de Especialidades "Bernardo Sepúlveda Gutiérrez", and the generation of knowledge].

    PubMed

    Cuevas-García, Carlos

    2016-01-01

    The history of the Hospital de Especialidades "Bernardo Sepúlveda Gutiérrez," formerly called Hospital General del Centro Médico Nacional, has been marked by ups and downs, as well as by the development of cutting-edge medical knowledge. In this supplement we show a series of articles, whose authors belong in their entirety to that hospital.

  10. Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands.

    PubMed

    Muixí, Laia; Carrascal, Montserrat; Alvarez, Iñaki; Daura, Xavier; Martí, Mercè; Armengol, Maria Pilar; Pinilla, Clemencia; Abian, Joaquín; Pujol-Borrell, Ricardo; Jaraquemada, Dolores

    2008-07-01

    Endocrine epithelial cells, targets of the autoimmune response in thyroid and other organ-specific autoimmune diseases, express HLA class II (HLA-II) molecules that are presumably involved in the maintenance and regulation of the in situ autoimmune response. HLA-II molecules thus expressed by thyroid cells have the "compact" conformation and are therefore expected to stably bind autologous peptides. Using a new approach to study in situ T cell responses without the characterization of self-reactive T cells and their specificity, we have identified natural HLA-DR-associated peptides in autoimmune organs that will allow finding peptide-specific T cells in situ. This study reports a first analysis of HLA-DR natural ligands from ex vivo Graves' disease-affected thyroid tissue. Using mass spectrometry, we identified 162 autologous peptides from HLA-DR-expressing cells, including thyroid follicular cells, with some corresponding to predominant molecules of the thyroid colloid. Most interestingly, eight of the peptides were derived from a major autoantigen, thyroglobulin. In vitro binding identified HLA-DR3 as the allele to which one of these peptides likely associates in vivo. Computer modeling and bioinformatics analysis suggested other HLA-DR alleles for binding of other thyroglobulin peptides. Our data demonstrate that although the HLA-DR-associated peptide pool in autoimmune tissue mostly belongs to abundant ubiquitous proteins, peptides from autoantigens are also associated to HLA-DR in vivo and therefore may well be involved in the maintenance and the regulation of the autoimmune response.

  11. Assessment of DR-55 as a Drop-In Replacement for R-410A

    SciTech Connect

    Shen, Bo; Abdelaziz, Omar

    2016-01-01

    R410A has no ozone depletion potential (ODP), and is the most commonly used refrigerant in vapor compression systems for space cooling and heating applications. However, it has significant global warming potential with GWP higher than 1900. To mitigate the global warming effect, industry and research institutes are actively pursuing a replacement for R-410A with the following attributes, much lower GWP along with similar or higher efficiency and capacity. DR-55 (aka R452B) is a design-compatible refrigerant replacement for R-410A. It decreases the GWP by 70%, and has lower working pressure, comparable discharge temperature, and uses the same lubricant, tubing, and valves. In this study, we experimentally evaluated the performance of DR-55 as a drop-in replacement for R-410A in a high efficiency rooftop air conditioning unit. The experimental results demonstrated that DR-55 led to 5% higher efficiency at the working conditions of Integrated Energy Efficiency Rating (IEER). DR-55 also showed significantly better high ambient performance from 95 F to 125 F. In addition to the experimental study, we used the DOE/ORNL Heat Pump Design Model to model the RTU using R-410A and DR-55, respectively. The model results were compared to the laboratory measurements. The model validation demonstrates that the refrigerant heat transfer and pressure drop correlations, developed for conventional refrigerants like R-410A, are usable for DR-55. Also, a converted compressor model for DR-55, i.e. reducing volumetric and isentropic efficiencies as a function of the suction and discharge pressures from an R-410A compressor map can predict the compressor mass flow rate and power accurately.

  12. Phenotypic and functional characteristics of HLA-DR(+) neutrophils in Brazilians with cutaneous leishmaniasis.

    PubMed

    Davis, Richard E; Sharma, Smriti; Conceição, Jacilara; Carneiro, Pedro; Novais, Fernanda; Scott, Phillip; Sundar, Shyam; Bacellar, Olivia; Carvalho, Edgar M; Wilson, Mary E

    2017-03-01

    The protozoan Leishmania braziliensis causes cutaneous leishmaniasis (CL) in endemic regions. In murine models, neutrophils (PMNs) are recruited to the site of infection soon after parasite inoculation. However, the roles of neutrophils during chronic infection and in human disease remain undefined. We hypothesized that neutrophils help maintain a systemic inflammatory state in subjects with CL. Lesion biopsies from all patients with CL tested contained neutrophils expressing HLA-DR, a molecule thought to be restricted to professional antigen-presenting cells. Although CL is a localized disease, a subset of patients with CL also had circulating neutrophils expressing HLA-DR and the costimulatory molecules CD80, CD86, and CD40. PMNs isolated from a low-density leukocyte blood fraction (LD-PMNs) contained a higher percentage of HLA-DR(+) PMNs than did normal-density PMNs. In vitro coculture experiments suggested LD-PMNs do not suppress T cell responses, differentiating them from MDSCs. Flow-sorted HLA-DR(+) PMNs morphologically resembled conventional PMNs, and they exhibited functional properties of PMNs. Compared with conventional PMNs, HLA-DR(+) PMNs showed increased activation, degranulation, DHR123 oxidation, and phagocytic capacity. A few HLA-DR(+) PMNs were observed in healthy subjects, and that proportion could be increased by incubation in either inflammatory cytokines or in plasma from a patient with CL. This was accompanied by an increase in PMN hladrb1 mRNA, suggesting a possible connection between neutrophil "priming" and up-regulation of HLA-DR. These data suggest that PMNs that are primed for activation and that also express surface markers of antigen-presenting cells emerge in the circulation and infected tissue lesions of patients with CL.

  13. [Clinic of environmental pediatric care in a high complexity hospital].

    PubMed

    Gaioli, Marisa; Amoedo, Diego; González, Daniel

    2014-12-01

    Children environmental health is considered by The World Health Organization as one of the main challenges of Public Health during the Century XXI. They promote the development of programs that allow approaching, disclosure or mitigation of the impact of polluting agents on health at every level of pediatric attention. The Children Hospital "Prof. Dr. Juan P. Garrahan" has created an Environmental Health Office in order to address the demands of those patients with suspected or verified exposure to environmental risks. An Environmental Clinical History has been elaborated with this purpose.

  14. Mrs. Chandrasekhar addresses the media in TRW Media Hospitality Tent

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Mrs. Lalitha Chandrasekhar (right), wife of the late Indian- American Nobel Laureate Subrahmanyan Chandrasekhar, addresses the media and other invited guests in the TRW Media Hospitality Tent at the NASA Press Site at KSC as Dr. Alan Bunner, Science Program Director, Structure and Evolution of the Universe, Office of Space Science, NASA Headquarters, Washington, D.C., looks on. The name 'Chandra,' a shortened version of her husband's name which he preferred among friends and colleagues, was chosen in a contest to rename the Advanced X-ray Astrophysics Facility. 'Chandra' also means 'Moon' or 'luminous' in Sanskrit. The observatory is scheduled to be launched aboard Columbia on Space Shuttle mission STS-93.

  15. Central line infections - hospitals

    MedlinePlus

    ... infection; CVC - infection; Central venous device - infection; Infection control - central line infection; Nosocomial infection - central line infection; Hospital acquired infection - central line infection; Patient safety - central ...

  16. Measuring hospital competition.

    PubMed

    White, S L; Chirikos, T N

    1988-03-01

    This paper appraises the use of the Herfindahl market share index as an exogenous competition variable in empirical studies of the hospital sector. An analysis of cross-sectional Florida data shows that this index itself is significantly influenced by the demand and supply factors commonly included in econometric models of hospital performance. The analysis then illustrates that biased inferences about the effects of market competition on the costs of hospital care may result unless the values of the Herfindahl Index are treated endogenously in hospital cost models.

  17. DrRad51 is required for chiasmata formation in meiosis in planarian Dugesia ryukyuensis.

    PubMed

    Chinone, Ayako; Matsumoto, Midori

    2014-05-01

    Rad51, a conserved eukaryotic protein, mediates the homologous-recombination repair of DNA double-strand breaks that occur during both mitosis and meiosis. During prophase I of meiosis, homologous recombination enhances the linkage between homologous chromosomes to increase the accuracy of segregation at anaphase I. In polyploidy situations, however, difficulties with homologous chromosome segregation often disrupt meiosis. Yet, triploid individuals of the planarian Dugesia ryukyuensis are able to produce functional gametes through a specialized form of meiosis. To shed light on the molecular mechanisms that promote successful meiosis in triploid D. ryukyuensis, we investigated rad51 gene function. We isolated three genes of the Rad51 family, the Rad51 homolog Dr-rad51 and the Rad51 paralogs Dr-rad51B and Dr-rad51C. Dr-rad51 was expressed in germ-line and presumably in somatic stem cells, but was not necessary for the regeneration of somatic tissue. RNA-interference (RNAi) depletion of Dr-rad51 during sexualization did not affect chromosome behavior in zygotene oocytes, but did result in the loss of chiasmata at the diplotene stage. Thus, homologous recombination does not appear to be necessary for synapsis, but is needed for crossover and proper segregation in D. ryukyuensis.

  18. Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions

    PubMed Central

    2011-01-01

    Background The amount of data on protein-protein interactions (PPIs) available in public databases and in the literature has rapidly expanded in recent years. PPI data can provide useful information for researchers in pharmacology and medicine as well as those in interactome studies. There is urgent need for a novel methodology or software allowing the efficient utilization of PPI data in pharmacology and medicine. Results To address this need, we have developed the 'Druggable Protein-protein Interaction Assessment System' (Dr. PIAS). Dr. PIAS has a meta-database that stores various types of information (tertiary structures, drugs/chemicals, and biological functions associated with PPIs) retrieved from public sources. By integrating this information, Dr. PIAS assesses whether a PPI is druggable as a target for small chemical ligands by using a supervised machine-learning method, support vector machine (SVM). Dr. PIAS holds not only known druggable PPIs but also all PPIs of human, mouse, rat, and human immunodeficiency virus (HIV) proteins identified to date. Conclusions The design concept of Dr. PIAS is distinct from other published PPI databases in that it focuses on selecting the PPIs most likely to make good drug targets, rather than merely collecting PPI data. PMID:21303559

  19. 50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams.

    PubMed

    Halford, Gayle M; Lordkipanidzé, Marie; Watson, Steve P

    2012-01-01

    2011 marks the 50th anniversary of the discovery of ibuprofen. This article is a focus on the personal reflections and career of Dr Stewart Adams OBE, the scientist whose research lead to the discovery of the cyclooxygenase inhibitor. When Dr Adams discovered ibuprofen, he was working as a pharmacologist in the Research Department for the Boots Pure Drug Company Ltd. Dr Adams was assigned to work on rheumatoid arthritis (RA) and chose in 1953 to search for a drug that would be effective in RA but would not be a corticosteroid. He was one of the first workers in this field that later became known as NSAIDs (Non-Steroidal Anti Inflammatory Drugs). In 1961, Dr Adams with John Nicholson, the organic chemist, filed a patent for the compound 2-(4-isobutylphenyl) propionic acid, later to become one of the most successful NSAIDs in the modern world, ibuprofen. In this article, Dr Adams gives his modest insight into the early stages and initial observations which led to this world-wide success.

  20. Principles of plastic surgery portrayed by the professional life of Dr John Peter Mettauer.

    PubMed

    Avashia, Yash J; Thaller, Seth R

    2011-11-01

    Regarded as "America's first plastic surgeon," Dr John Peter Mettauer's professional life displays 3 fundamental keystones of plastic surgery: education, innovation, and practice. To fully appreciate the history of our plastic surgery, one must look beyond a purely factual recount of noteworthy actions performed decades ago. Fundamental principles that governed achievements of our predecessors remain applicable even today. Dr Mettauer thrived as a medical student under the influence of distinguished professors in medicine at the University of Pennsylvania. Later, he continued to propagate their basic tenets when he established his medical institute in 1837. Throughout his life, Dr Mettauer combined ingenuity with scientific inquiry to devise numerous unprecedented surgical techniques and instruments. He was a prolific writer and exquisitely documented his work in medical journals for the benefit of both contemporary and future surgeons. One of Dr Mettauer's momentous achievements in plastic surgery that displays his remarkable capabilities was his contributions to management of both simple and complicated cases of cleft palate. He was the first to describe relaxing lateral incisions for treating complete cleft palates and, incidentally, was the first to successfully treat this in America. He invariably replicated similar success in establishing techniques for treating a wide range of anatomic deformities. Cumulatively, Dr Mettauer's lifelong commitment and diligence have truly laid a foundation for the eventual progress and success in the field of plastic surgery.

  1. Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice

    PubMed Central

    Andersson, Ellen Christina; Hansen, Bjarke Endel; Jacobsen, Helle; Madsen, Lars S.; Andersen, Claus B.; Engberg, Jan; Rothbard, Jonathan B.; McDevitt, Grete Sønderstrup; Malmström, Vivianne; Holmdahl, Rikard; Svejgaard, Arne; Fugger, Lars

    1998-01-01

    Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II collagen (CII) is a candidate, and the DR4- and DR1-restricted immunodominant T cell epitope in this protein corresponds to amino acids 261–273 (CII 261–273). We have defined MHC and T cell receptor contacts in CII 261–273 and provide strong evidence that this peptide corresponds to the peptide binding specificity previously found for RA-associated DR molecules. Moreover, we demonstrate that HLA-DR4 and human CD4 transgenic mice homozygous for the I-Abβ0 mutation are highly susceptible to collagen-induced arthritis and describe the clinical course and histopathological changes in the affected joints. PMID:9636191

  2. An HPLC method associated with a thermodynamic analysis to compare the binding of TRAIL and its nanovectorized form to death receptors DR4 and DR5 and their relationship to cytotoxicity.

    PubMed

    Guillaume, Yves Claude; Lethier, Lydie; André, Claire

    2016-11-15

    TRAIL is a member of the TNF family of cytokines which induces apoptosis of cancer cells via its binding to its cognate receptors, DR5 a high affinity site and DR4 a site of low affinity. Our working group has recently demonstrated that nanovectorization of TRAIL with single wall carbon nanotubes (abbreviated NPT) enhanced TRAIL affinity to the high affinity site DR5 and increased pro apoptotic potential in different human tumor cell lines. In this paper, the DR4 low affinity site was immobilized on a chromatographic support and the effect of temperature on a wide temperature range 1°C-50°C was studied to calculate the thermodynamic parameters of the binding of TRAIL and NPT to DR4 and DR5 receptors. For the first time the heat capacity changes for the different binding processes were determined. At a physiological pH (7.4) the heat capacity changes for the binding of NPT to DR4 and DR5 were respectively equal to -0.91kJ/molK and -0.28kJ/molK and those obtained for the binding of TRAIL to DR4 and DR5 were respectively equal to -1.54kJ/molK and -1.05kJ/molK. By the use of differential scanning calorimetry (DSC), a phase transition (∼12°C for DR5, ∼4°C for DR4) between a disordered (low temperature) and an ordered (high temperature) solid like state visualized in the receptor structure confirmed the temperature dependence of binding affinity enthalpy ΔH for soluble TRAIL and its nanovectorized form to its cognate receptors. In the low temperature domain, the positive ΔH values contribute non-favourably to the free energy of binding, TRAIL and NPT described similar affinities for DR4 and DR5. For the high temperature domain, negative ΔH values indicated that van der Waals interactions and hydrogen bonding are engaged favourably at the ligand - receptor interface. Above 30°C, their rank-ordered affinities were thus strongly different in the sequence: TRAILDR4DR4 and DR5

  3. Hospitality Occupations. Curriculum Guide.

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento. Bureau of Homemaking Education.

    This curriculum guide on the hospitality occupations was developed to help secondary and postsecondary home economics teachers prepare individuals for entry-level jobs in the hospitality industry. The content is in seven sections. The first section presents organizational charts of a medium-size hotel, food and beverage division, housekeeping and…

  4. Hospitality, Tourism, and Recreation.

    ERIC Educational Resources Information Center

    Novachek, James

    The Northern Arizona Hospitality Education Program is an exemplary three-year project designed to help students, mainly Indian, obtain job skills and attitudes necessary for successful employment in the hospitality industry. Nine high schools from Apache, Coconino, and Navajo Counties participated in the project. Objectives included providing an…

  5. Handbook on Hospital Television.

    ERIC Educational Resources Information Center

    Prynne, T. A.

    Designed for both hospital personnel interested in television and audiovisual personnel entering the medical field, this handbook is a verbal and pictorial survey of what is being done with TV within the medical profession. After an introduction which answers technical questions about medical TV posed during the American Hospital Association's…

  6. Hospitality Services. Curriculum Guide.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    This guide, which was developed as part of Texas' home economics education program, is intended to assist teachers of a hospitality services course focusing on the food and lodging segments of the hospitality and tourism industry. The first 40% of the approximately 600-page guide consists of strategies for teaching each of 29 essential…

  7. Hospitality Services Reference Book.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    This reference book provides information needed by employees in hospitality services occupations. It includes 29 chapters that cover the following topics: the hospitality services industry; professional ethics; organization and management structures; safety practices and emergency procedures; technology; property maintenance and repair; purchasing…

  8. Virtual Pediatric Hospital

    MedlinePlus

    ... Thoracopaedia - An Imaging Encyclopedia of Pediatric Thoracic Disease Virtual Pediatric Hospital is the Apprentice's Assistant™ Last revised ... pediatric resources: GeneralPediatrics.com | PediatricEducation.org | SearchingPediatrics.com Virtual Pediatric Hospital is curated by Donna M. D' ...

  9. Hospital benefit segmentation.

    PubMed

    Finn, D W; Lamb, C W

    1986-12-01

    Market segmentation is an important topic to both health care practitioners and researchers. The authors explore the relative importance that health care consumers attach to various benefits available in a major metropolitan area hospital. The purposes of the study are to test, and provide data to illustrate, the efficacy of one approach to hospital benefit segmentation analysis.

  10. Leading a hospital closure.

    PubMed

    Lucey, Paula A

    2002-01-01

    Hospital closures have become more common. The challenges facing a nursing leader in this situation are complex and difficult. This author suggests that looking for new beginnings rather than focusing on endings created an approach to closing a public hospital. The article includes approaches to employee morale, staffing, and patient care.

  11. Competition among hospitals.

    PubMed

    Gaynor, Martin; Vogt, William B

    2003-01-01

    We examine competition in the hospital industry, in particular the effect of ownership type (for-profit, not-for-profit, government). We estimate a structural model of demand and pricing in the hospital industry in California, then use the estimates to simulate the effect of a merger. California hospitals in 1995 face an average price elasticity of demand of -4.85. Not-for-profit hospitals face less elastic demand and act as if they have lower marginal costs. Their prices are lower than those of for-profits, but markups are higher. We simulate the effects of the 1997 merger of two hospital chains. In San Luis Obispo County, where the merger creates a near monopoly, prices rise by up to 53%, and the predicted price increase would not be substantially smaller were the chains not-for-profit.

  12. Collected Papers in Structural Mechanics Honoring Dr. James H. Starnes, Jr.

    NASA Technical Reports Server (NTRS)

    Knight, Norman F., Jr. (Compiler); Nemeth, Michael P. (Compiler); Malone, John B. (Compiler)

    2006-01-01

    This special publication contains a collection of structural mechanics papers honoring Dr. James H. Starnes, Jr. presented at the 46th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference held in Austin, Texas, April 18-21, 2005. Contributors to this publication represent a small number of those influenced by Dr. Starnes' technical leadership, his technical prowess and diversity, and his technical breath and depth in engineering mechanics. These papers cover some of the research areas Dr. Starnes investigated, which included buckling, postbuckling, and collapse of structures; composite structural mechanics, residual strength and damage tolerance of metallic and composite structures; and aircraft structural design, certification and verification. He actively pursued technical understanding and clarity, championed technical excellence, and modeled humility and perseverance.

  13. Identification and clinical relevance of naturally occurring human CD8+HLA-DR+ regulatory T cells.

    PubMed

    Arruvito, Lourdes; Payaslián, Florencia; Baz, Plácida; Podhorzer, Ariel; Billordo, Ariel; Pandolfi, Julieta; Semeniuk, Guillermo; Arribalzaga, Eduardo; Fainboim, Leonardo

    2014-11-01

    The lack of responsiveness to self and non-self Ags is normally maintained by multiple mechanisms, including the suppressive activities of several T cell subsets. In this study, we show that CD8(+) T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8(+) regulatory T cell subset. Their suppressive effect appears to be cell-to-cell contact dependent and may involve CTLA-4 signaling between neighboring T cells. These regulatory T cells can be expanded in vitro and exhibit a suppressive capacity similar to that observed in ex vivo CD8(+)HLA-DR(+) T cells. The high frequency of CD8(+)HLA-DR(+) T cells that we detected in patients with non-small cell lung cancer deserves further work to confirm their putative suppressor effect within the tumor.

  14. The Case of Dr. Oz: Ethics, Evidence, and Does Professional Self-Regulation Work?

    PubMed

    Tilburt, Jon C; Allyse, Megan; Hafferty, Frederic W

    2017-02-01

    Dr. Mehmet Oz is widely known not just as a successful media personality donning the title "America's Doctor(®)," but, we suggest, also as a physician visibly out of step with his profession. A recent, unsuccessful attempt to censure Dr. Oz raises the issue of whether the medical profession can effectively self-regulate at all. It also raises concern that the medical profession's self-regulation might be selectively activated, perhaps only when the subject of professional censure has achieved a level of public visibility. We argue here that the medical profession must look at itself with a healthy dose of self-doubt about whether it has sufficient knowledge of or handle on the less visible Dr. "Ozes" quietly operating under the profession's presumptive endorsement.

  15. The conviction of Dr. Crippen: new forensic findings in a century-old murder.

    PubMed

    Foran, David R; Wills, Beth E; Kiley, Brianne M; Jackson, Carrie B; Trestrail, John H

    2011-01-01

    Dr. Hawley Crippen was accused and convicted of murdering his wife in London in 1910. Key to the conviction was microscopic analysis of remains found in the Crippen's coal cellar, which were identified as Cora Crippen based on a scar she was said to have. Dr. Crippen was hanged, always proclaiming his innocence. In this study, genealogical research was used to locate maternal relatives of Cora Crippen, and their mitochondrial haplotypes were determined. Next, one of the pathology slides of the scar was obtained, DNA was isolated, and the haplotype was determined. That process was then repeated. Finally, both DNA isolates were assayed for repetitive elements on autosomes and repetitive elements specific to the Y chromosome. Based on the genealogical and mitochondrial DNA research, the tissue on the pathology slide used to convict Dr. Crippen was not that of Cora Crippen. Moreover, that tissue was male in origin.

  16. VizieR Online Data Catalog: PACS Evolutionary Probe (PEP-DR1) catalogs (Lutz+, 2011)

    NASA Astrophysics Data System (ADS)

    Lutz, D.; Poglitsch, A.; Altieri, B.; Andreani, P.; Aussel, H.; Berta, S.; Bongiovanni, A.; Brisbin, D.; Cava, A.; Cepa, J.; Cimatti, A.; Daddi, E.; Dominguez-Sanchez, H.; Elbaz, D.; Foerster Schreiber, N. M.; Genzel, R.; Grazian, A.; Gruppioni, C.; Harwit, M.; Le Floc'h, E.; Magdis, G.; Magnelli, B.; Maiolino, R.; Nordon, R.; Perez Garcia, A. M.; Popesso, P.; Pozzi, F.; Riguccini, L.; Rodighiero, G.; Saintonge, A.; Sanchez Portal, M.; Santini, P.; Shao, L.; Sturm, E.; Tacconi, L. J.; Valtchanov, I.; Wetzstein, M.; Wieprecht, E.

    2013-11-01

    PACS catalogs built by the PEP team, with key contributions by Stefano Berta, Benjamin Magnelli, Paola Popesso, Dieter Lutz, Francesca Pozzi, Bruno Altieri, Herve Aussel, Hoseong Hwang, Emeric Le Floc'h, Georgios Magdis, Raanan Nordon, Albrecht Poglitsch, Laurie Riguccini, Amelie Saintonge, Li Shao. For more details, please refer to Lutz et al. (2011A&A...532A..90L) and to the PDF documentation associated to the release. Data and catalogs can be retrieved from the web page http://www.mpe.mpg.de/ir/Research/PEP/publicdatareleases.php See the PDF documentation associated to the PEP DR1 release, http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_global.pdf and http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_SPIRE.pdf for more details. (69 data files).

  17. Maribor General Hospital from its foundation until World War II.

    PubMed

    Pivec, Gregor

    2006-01-01

    The author describes the history of Maribor General Hospital from its foundation in 1799 until the beginning of World War II. In 1799 the magistrate of the town of Maribor issued a memorandum regarding the establishment of a town hospital in the renovated building of the town hospice, providing space for 24 patients. The work of the hospital was carried out in the former hospice building until 1855. In the period between its establishment and eventual relocation 26 beds were added. The last two decades of the hospital's operation at the original location were marked by the assiduous work of the town's physicist, Dr. Anton Kuker. In the first half of the 19th century, the population of Maribor grew rapidly as a consequence of the construction of the Southern Railway. The town authorities therefore purchased the Prosenjak family villa in the Magdalena suburbs and relocated the hospital to it in 1855, providing 28 rooms for 110 patients. For a whole century, the care of patients was taken over by the Daughters of Charity of Saint Vincent de Paul. The hospital was soon admitting over 1000 patients a year, the most common complaints being pulmonary catarrh, gastritis and fever. In 1872, when the Master of Surgery Feliks Ferk joined the hospital, the internal "medical" and the "external" surgical departments were formed. Although medical studies were not easily accessible, there were a number of Slovene physicians working in the hospital and the town in that period. In the last decades of the 19th century, the hospital was often renovated and enlarged. The infrastructure (telephone, water supply system, heating, lighting) had also been modernized before World War I. In 1914, the first X-ray apparatus was purchased. Between the wars, the hospital's development was boosted by recruitment of the Slovene physicians Ivan Matko, Mirko Cernic, Janko Dernovsek and Hugon Robic. The initial external and medical departments split into several departments: internal medicine, surgery

  18. Association between risk for pre-eclampsia and HLA DR4

    SciTech Connect

    Not Available

    1990-03-17

    Dr. Kilpatrick and colleagues report results of a family study showing an association between HLA DR4 and mild and proteinuric pre-eclampsia in a British (Edinburgh) maternal population. Among 76 parous sisters of women with protein uric pre-eclampsia, they found that sisters with pregnancy-induced hypertension (pre-eclampsia with or without proteinuria) had a higher frequency of HLA DR4 antigen than did normotensive sisters. In addition, they cited unpublished findings in which they found a higher frequency of HLA DR4 antigen in a large sample of pre-eclamptic women and their babies than in appropriate controls. The authors have completed a study of HLA antigens and pregnancy outcome among a coherent of 715 black (50.9%) and white (49.1%) primigravida who were delivered at a medical center in southern USA. HLA DR typing was done by the one-color fluorescence technique with reagents. On the basis of standard criteria for diagnosis of pre-eclampsia and eclampsia, 6.9 of the cohort had mild non-proteinuric pre-eclampsia, 8.8% had pregnancy-induced hypertension, and 9.5% had combined pre-eclampsia and eclampsia. Whereas black women had higher rates than white women in all three clinical categories (eg, pregnancy-induced hypertension 10.7% vs 6.8%, respectively), differences were not significant and frequencies of HLA DR4 antigen were higher among normotensives in both races (results not shown). They therefore pooled the two racial groups for analyses.

  19. DR-induced escape of O and C from early Mars

    NASA Astrophysics Data System (ADS)

    Zhao, Jinjin; Tian, Feng; Ni, Yufang; Huang, Xiaomeng

    2017-03-01

    Energetic particles produced in Dissociative recombination (DR) reactions could escape planets with low gravity, such as Mars, if they could overcome collisions with the surrounding background gases. In this work, a 3-D Monte Carlo model is developed to study these photochemical escape processes on early Mars. Although the DR reaction rates of O2+, CO2+, and CO+ increase monotonically with solar soft X-ray and extreme ultraviolet (XUV) flux, the peak of the calculated DR-induced escape rates of O is near 3 × XUV, and the DR-induced escape rates of C increase with XUV until 10 × XUV. The non-monotonic behavior can be explained by the increased column densities of background species in high XUV conditions, which can deflect energetic particles through collisions more efficiently. At 20 × XUV, CO+ DR is the main source of escaping O and C, and the escape of secondary particles could contribute to 30∼40% and 10% of the total escape of O and C respectively. The time-integrated DR-induced escape of O and C is equivalent to 1 m of H2O and 20 mbar of CO2 escaping early Mars since 4.5 billion years ago. The accumulated CO2 loss is much lower than what's needed to explain the carbon isotopic ratios on Mars and much lower than the total CO2 needed to warm up early Mars. If more vigorous escape mechanisms were absent on early Mars, substantial inventories of volatiles have not been detected yet.

  20. Analysis of HLA-DR glycoproteins by DNA-mediated gene transfer. Definition of DR2 beta gene products and antigen presentation to T cell clones from leprosy patients

    PubMed Central

    1988-01-01

    We have used DNA-mediated gene transfer to express HLA class II molecules in mouse L cells for serological, biochemical, and functional analysis. cDNA clones encoding the DR2 beta a and DR2 beta b products of the DR2Dw2 haplotype were subcloned into a mouse Moloney leukemia virus-based expression vector (pJ4) and transfected separately into mouse L cells together with a HLA-DR alpha/pJ4 construct. These transfectants have allowed differential analysis of the two DR2 beta products in a manner normally prohibited by the concomitant expression seen in B cells. Two-dimensional SDS-PAGE analysis of the transfectants defines the more acidic beta chain as the product of the DR2 beta a sequence, and the more basic chain as the product of the DR2 beta b sequence. The LDR2a transfectants present antigen efficiently to M.leprae-specific T cell clones and are capable of presenting synthetic peptide, 65-kD recombinant mycobacterial antigen and M.leprae. Of the DR2Dw2-restricted T cell clones we have tested, all use the DR2 beta a chain as their restriction element. Inhibition studies with mAbs demonstrate the dependence of presentation by the transfectant on class II and CD4, while mAbs against LFA-1, which substantially inhibit presentation by B-lymphoblastoid cell lines, do not inhibit transfectant presentation. PMID:3128633

  1. HLA-DR antigens in systemic lupus erythematosus: association with specificity of autoantibody responses to nuclear antigens.

    PubMed Central

    Smolen, J S; Klippel, J H; Penner, E; Reichlin, M; Steinberg, A D; Chused, T M; Scherak, O; Graninger, W; Hartter, E; Zielinski, C C

    1987-01-01

    HLA-DR antigens and autoantibodies to the nuclear or cytoplasmic antigens Ro/SSA, La/SSB, Sm, and RNP were determined in North American and Austrian patients with systemic lupus erythematosus (SLE). Analysis of the association of antibodies to these ribonucleic acid (RNA)-protein antigens with HLA-DR antigens showed that HLA-DR3 was related to the presence of anti-Ro/SSA or anti-La/SSB, or both. In contrast, anti-Sm or anti-RNP, or both were associated with HLA-DR4. HLA-DR5 was associated with absence of these autoantibodies. The data extend evidence for the complexity and heterogeneity of SLE. Moreover, they indicate that, in SLE, genes linked to those coding for HLA-DR antigens, are related to the specificity of autoantibody responses rather than to the primary immunological abnormalities of this disorder. PMID:3498447

  2. Doppler transcranien au cours de la drépanocytose chez l'enfant Malagasy

    PubMed Central

    Herinirina, Nicolas Fanantenana; Rajaonarison, Lova Hasina Ny Ony Narindra; Herijoelison, Andry Roussel; Rakoto, Olivat Aimée Alson; Ahmad, Ahmad

    2016-01-01

    Introduction Le doppler transcrânien est un outil efficace permettant de dépister les enfants drépanocytaires à risque d'AVC. Méthodes Nous avons réalisé une étude descriptive transversale sur des enfants Malagasy âgés entre 24 mois et 15 ans (groupe 1: 57 drépanocytaires, groupe 2: 43 témoins) afin d’évaluer le profil vélocimétrique des artères cérébrales chez les drépanocytaires. Un examen Doppler transcrânien a été réalisé avec étude des flux sanguins cérébraux chez les enfants des deux groupes. Résultats Pour les sujets drépanocytaires, la vitesse moyenne (VM) de l'artère cérébrale moyenne était de 100,9 ± 26,8 cm/s, l'indice de pulsatilité (IP) de 0,73 ± 0,20, la différence entre les artères cérébrales moyennes droite et gauche (ACMr) de 19,8 ± 21,5 cm/s, le rapport des vitesses de l'artère cérébrale antérieure/artère cérébrale moyenne (ACA/ACM) de 0,7 ± 0,2. Pour les enfants non drépanocytaires, VM: 80,6 ± 19,3 cm/s, IP: 0,79 ± 0,14, ACMr: 17 ± 20,1 cm/s, ACA/ACM: 0,8 ± 0,2. La vélocité des enfants drépanocytaires était supérieure au groupe contrôle. Les vitesses ont été corrélées avec le taux d'hémoglobine et l’âge et non pas avec le sexe et le volume globulaire moyen. Conclusion Les vitesses circulatoires cérébrales sont élevées chez les drépanocytaires que les enfants non drépanocytaires et sont influencées par le taux d'hémoglobine et l’âge. PMID:27516829

  3. The medical ethics of the 'father of gynaecology', Dr J Marion Sims.

    PubMed Central

    Ojanuga, D

    1993-01-01

    Vesico-vaginal fistula (VVF) was a common ailment among American women in the 19th century. Prior to that time, no successful surgery had been developed for the cure of this condition until Dr J Marion Sims perfected a successful surgical technique in 1849. Dr Sims used female slaves as research subjects over a four-year period of experimentation (1845-1849). This paper discusses the controversy surrounding his use of powerless women and whether his actions were acceptable during that historical period. PMID:8459435

  4. The solution structure of the invasive tip complex from Afa/Dr fibrils.

    PubMed

    Cota, Ernesto; Jones, Celine; Simpson, Peter; Altroff, Harri; Anderson, Kirstine L; du Merle, Laurence; Guignot, Julie; Servin, Alain; Le Bouguénec, Chantal; Mardon, Helen; Matthews, Stephen

    2006-10-01

    Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition.

  5. BEopt-CA (Ex): A Tool for Optimal Integration of EE, DR and PV in Existing California Homes

    SciTech Connect

    Christensen, Craig; Horowitz, Scott; Maguire, Jeff; Velasco, Paulo Tabrares; Springer, David; Coates, Peter; Bell, Christy; Price, Snuller; Sreedharan, Priya; Pickrell, Katie

    2014-04-01

    This project targeted the development of a software tool, BEopt-CA (Ex) (Building Energy Optimization Tool for California Existing Homes), that aims to facilitate balanced integration of energy efficiency (EE), demand response (DR), and photovoltaics (PV) in the residential retrofit1 market. The intent is to provide utility program managers and contractors in the EE/DR/PV marketplace with a means of balancing the integration of EE, DR, and PV

  6. Hospital ICUs May Be Overused

    MedlinePlus

    ... care in non-ICU settings," said Dr. Dong Chang. He is a researcher at the Los Angeles ... frequently invasive and comes at a substantial cost," Chang added. The researchers tracked just over 800 patients ...

  7. Hospitals' Internal Accountability

    PubMed Central

    Kraetschmer, Nancy; Jass, Janak; Woodman, Cheryl; Koo, Irene; Kromm, Seija K.; Deber, Raisa B.

    2014-01-01

    This study aimed to enhance understanding of the dimensions of accountability captured and not captured in acute care hospitals in Ontario, Canada. Based on an Ontario-wide survey and follow-up interviews with three acute care hospitals in the Greater Toronto Area, we found that the two dominant dimensions of hospital accountability being reported are financial and quality performance. These two dimensions drove both internal and external reporting. Hospitals' internal reports typically included performance measures that were required or mandated in external reports. Although respondents saw reporting as a valuable mechanism for hospitals and the health system to monitor and track progress against desired outcomes, multiple challenges with current reporting requirements were communicated, including the following: 58% of survey respondents indicated that performance-reporting resources were insufficient; manual data capture and performance reporting were prevalent, with the majority of hospitals lacking sophisticated tools or technology to effectively capture, analyze and report performance data; hospitals tended to focus on those processes and outcomes with high measurability; and 53% of respondents indicated that valuable cross-system accountability, performance measures or both were not captured by current reporting requirements. PMID:25305387

  8. 76 FR 11526 - In the Matter of Dr. Gary Kao; Order Prohibiting Involvement In NRC-Licensed Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... therapeutic purposes. The therapeutic treatments include brachytherapy iodine-125 used for permanent prostate implants. Dr. Kao was an approved authorized user for brachytherapy iodine-125 used for permanent...

  9. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    SciTech Connect

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

  10. MTB-DR-RIF 9G test: Detection and discrimination of tuberculosis and multi-drug resistant tuberculosis strains.

    PubMed

    Song, Keum-Soo; Nimse, Satish Balasaheb; Cho, Nam Hoon; Sung, Nackmoon; Kim, Hee-Jin; Yang, Jeongseong; Kim, Taisun

    2015-12-01

    This report describes the evaluation of the novel MTB-DR-RIF 9G test for the accurate detection and discrimination of Mycobacterium tuberculosis (MTB) and rifampicin-resistant M. tuberculosis (MTB-DR-RIF) in the clinical samples. The procedure included the amplification of a nucleotide fragment of the rpoB gene of the MTB and MTB-DR-RIF strains and their hybridization with the immobilized probes. The MTB-DR-RIF 9G test was evaluated for its ability to detect and discriminate MTB and MTB-DR-RIF strains in 113 known clinical samples. The accuracy of the MTB-DR-RIF 9G test was determined by comparing its results with sequencing analysis and drug susceptibility testing. The sensitivity and specificity of the MTB-DR-RIF 9G test at 95% confidence interval were found to be 95.4% (89.5-98.5) and 100% (69.2-100), respectively. The positive predictive value and negative predictive value of the MTB-DR-RIF 9G test at 95% confidence interval were found to be 100% (85.0-95.9) and 66.7% (38.4-88.18), respectively. Sequencing analysis of all samples indicated that the mutations present in the regions identified with the MTB-DR-RIF 9G assay can be detected accurately.

  11. [Frequency and linkage disequilibrium of specific HLA-DR and HLA-DQ genes in Chinese Han population].

    PubMed

    Yang, Su-Xia; Hu, Zhi-Fei; Zu, Qiang; Lu, Jin-Shan; Zhang, Xu; Dong, Jun

    2012-12-01

    This study was aimed to investigate the distribution feature of HLA-DR/DQ gene linkage disequilibrium in Chinese Han population and to improve the accuracy of HLA matching results. Genotyping of HLA-DR and HLA-DQ gene locus was performed using PCR-SSP typing in Chinese Han population receiving kidney transplantation. The results showed that there were 29 new linkage combinations in 1799 patients, in which DR13-DQ5, DR11-DQ8 and DR8-DQ8 were discovered for 11, 8 and 7 times respectively while DR9-DQ8, DR12-DQ6 and DR14-DQ4 were both discovered for 6 times. The linkage disequilibrium parameters of these haplotypes were negative, showing that these linkages were uncommon. It is concluded that this study not only enriches the classical HLA-DR/DQ linkage combinations, but also indicates the national relevance of combination distribution, and it has great importance in improving the accuracy of HLA matching experiments and reducing unnecessary repeated work.

  12. Hospital service recovery.

    PubMed

    Gutbezahl, Cary; Haan, Perry

    2006-01-01

    An organization's ability to correct service errors is an important factor in achieving success in today's service economy. This paper examines service recovery in hospitals in the U.S. First is a general review of service recovery theories. Next is a discussion of specific service issues related to the hospital environment. The literature on service recovery is used to make specific recommendations to hospitals for ways to improve their ability to remedy service errors when they occur. Suggestions for future research in the field of service recovery are also made.

  13. Predicting hospital accounting costs

    PubMed Central

    Newhouse, Joseph P.; Cretin, Shan; Witsberger, Christina J.

    1989-01-01

    Two alternative methods to Medicare Cost Reports that provide information about hospital costs more promptly but less accurately are investigated. Both employ utilization data from current-year bills. The first attaches costs to utilization data using cost-charge ratios from the previous year's cost report; the second uses charges from current year's bills. The first method is the more accurate of the two, but even using it, only 40 percent of hospitals had predicted costs within plus or minus 5 percent of actual costs. The feasibility and cost of obtaining cost reports from a small, fast-track sample of hospitals should be investigated. PMID:10313352

  14. A 1911 postcard of the National Hospital for the Paralysed and Epileptic highlighting European medical specialty training

    PubMed Central

    Zubair, Adeel

    2017-01-01

    The purpose of this study was to describe the historical importance of a 1911 European hospital postcard sent from one American physician to another. In the late 19th and early 20th centuries, very few formal residency programs existed in America for training physicians. Most authors rightfully emphasize Johns Hopkins Hospital, founded in 1889, as the site of origin of the American medical residency, but these positions were for a chosen few. Many young physicians would go abroad to study medicine after completing medical school, a decision with many benefits and few drawbacks. At least 15,000 Americans took some kind of medical training in Austria-Hungary, Germany, and Switzerland between 1870 and 1914. Dr. Frank F. Hutchins took such a trip to Europe. On March 12, 1911, Dr. Hutchins wrote a postcard from Queen Square, London, to Dr. Allison Maxwell admiring the positive attributes of The National Hospital for the Paralysed and Epileptic. This trip would serve to shape Dr. Hutchins' subsequent career and would influence the future of the Indiana University School of Medicine, neuropsychiatry in the US military, and the care of veterans. PMID:28127153

  15. Brigham and Women's Hospital three-time winner of the American Pain Society Clinical Centers of Excellence Award.

    PubMed

    Ross, Edgar

    2017-01-01

    Edgar Ross speaks to Jade Parker, Commissioning Editor: Dr Edgar Ross is a member of the Anesthesia Department at Brigham and Women's Hospital. His main office is in Chesnut Hill, an ambulatory care center for Brigham and Women's hospital. He received his medical degree from Wayne State University School of Medicine and has been in practice for more than 30 years, 20 years in his current position at Brigham and Women's Hospital. His two main clinical interests are; the phone app which is designed to become the main clinical tool for patients and second, the relationship between opioids and angiogenesis.

  16. Milk Flow Rates From Bottle Nipples Used for Feeding Infants Who Are Hospitalized

    PubMed Central

    Park, Jinhee; Thoyre, Suzanne M.; Estrem, Hayley; Nix, W. Brant

    2015-01-01

    Purpose This study tested the milk flow rates and variability in flow of currently available nipples used for bottle-feeding infants who are hospitalized. Method Clinicians in 3 countries were surveyed regarding nipples available to them for feeding infants who are hospitalized. Twenty-nine nipple types were identified, and 10 nipples of each type were tested by measuring the amount of infant formula expressed in 1 min using a breast pump. Mean milk flow rate (mL/min) and coefficient of variation were used to compare nipples within brand and within category (i.e., Slow, Standard, Premature). Results Flow rates varied widely between nipples, ranging from 2.10 mL/min for the Enfamil Cross-Cut to 85.34 mL/min for the Dr. Brown's Y-Cut Standard Neck. Variability of flow rates among nipples of the same type ranged from a coefficient of variation of 0.05 for Dr. Brown's Level 1 Standard- and Wide-Neck to 0.42 for the Enfamil Cross-Cut. Mean coefficient of variation by brand ranged from 0.08 for Dr. Brown's to 0.36 for Bionix. Conclusions Milk flow is an easily manipulated variable that may contribute to the degree of physiologic instability experienced by infants who are medically fragile during oral feeding. This study provides clinicians with information to guide appropriate selection of bottle nipples for feeding infants who are hospitalized. PMID:26172340

  17. Hospital-acquired thrombocytopenia.

    PubMed

    McMahon, Christine M; Cuker, Adam

    2014-10-01

    The development of thrombocytopenia is common in hospitalized patients and is associated with increased mortality. Frequent and important causes of thrombocytopenia in hospitalized patients include etiologies related to the underlying illness for which the patient is admitted, such as infection and disseminated intravascular coagulation, and iatrogenic etiologies such as drug-induced immune thrombocytopenia, heparin-induced thrombocytopenia, posttransfusion purpura, hemodilution, major surgery, and extracorporeal circuitry. This review presents a brief discussion of the pathophysiology, distinguishing clinical features, and management of these etiologies, and provides a diagnostic approach to hospital-acquired thrombocytopenia that considers the timing and severity of the platelet count fall, the presence of hemorrhage or thrombosis, the clinical context, and the peripheral blood smear. This approach may offer guidance to clinicians in distinguishing among the various causes of hospital-acquired thrombocytopenia and providing management appropriate to the etiology.

  18. Surgery, Hospitals, and Medications

    MedlinePlus

    ... products that are not commonly stocked in hospital pharmacies. Examples include: Salagen ® , Evoxac ® , and Restasis ® Eye drops, ... prescription and OTC medications/products in their labeled pharmacy container or packaging. This is important in case ...

  19. Home versus hospital confinement

    PubMed Central

    Barry, C. N.

    1980-01-01

    The case for hospital rather than home delivery has been powerfully argued, especially in and since the Report of the Peel Committee. Nevertheless, evidence of comparison with other countries, notably the Netherlands, suggests the choice is not necessarily simple. Some general practitioner units are now reporting perinatal mortality rates which are consistently lower than those of specialist units, and recent statistical analyses suggest that the presence of more high risk cases in consultant units does not explain this. The only big controlled home-versus-hospital trial did not lead to a significantly lower perinatal mortality rate in the hospital group. The onus of proof now seems to lie with those who advocate 100 per cent hospital confinement. PMID:7373581

  20. Objections to hospital philosophers.

    PubMed Central

    Ruddick, W; Finn, W

    1985-01-01

    Like morally sensitive hospital staff, philosophers resist routine simplification of morally complex cases. Like hospital clergy, they favour reflective and principled decision-making. Like hospital lawyers, they refine and extend the language we use to formulate and defend our complex decisions. But hospital philosophers are not redundant: they have a wider range of principles and categories and a sharper eye for self-serving presuppositions and implicit contradictions within our practices. As semi-outsiders, they are often best able to take an 'external point of view,' unburdened by routine, details, and departmental loyalties. Their clarifications can temporarily disrupt routine, but can eventually improve staff morale, hence team practice and patient welfare. PMID:3981573

  1. Hospital free cash flow.

    PubMed

    Kauer, R T; Silvers, J B

    1991-01-01

    Hospital managers may find it difficult to admit their investments have been suboptimal, but such investments often lead to poor returns and less future cash. Inappropriate use of free cash flow produces large transaction costs of exit. The relative efficiency of investor-owned and tax-exempt hospitals in the product market for hospital services is examined as the free cash flow theory is used to explore capital-market conditions of hospitals. Hypotheses concerning the current competitive conditions in the industry are set forth, and the implications of free cash flow for risk, capital-market efficiency, and the cost of capital to tax-exempt institution is compared to capital-market norms.

  2. American Hospital Association

    MedlinePlus

    ... Hospitals & Health Networks H & HN Daily Trustee Research & Trends AHA Policy Research Health Research & Educational Trust AHA ... Associations unless otherwise indicated. AHA does not claim ownership of any content, including content incorporated by permission ...

  3. Advance directives are the solution to Dr Campbell's problem for voluntary euthanasia.

    PubMed Central

    Flew, A

    1999-01-01

    Dr Neil Campbell suggests that when patients suffering extremes of protracted pain ask for help to end their lives, their requests should be discounted as made under compulsion. I contend that the doctors concerned should be referred to and then act upon advance directives made by those patients when of sound and calm mind and afflicted by no such intolerable compulsion. PMID:10390680

  4. Dr. Clarke vs. the "Ladies": Coeducation and Women's Roles in the 1870's.

    ERIC Educational Resources Information Center

    Seller, Maxine S.

    Negative reaction to the theories forwarded in Dr. Edward H. Clarke's 1873 treatise against coeducation, "Sex in Education or A Fair Chance for the Girls," has been largely neglected. The book appeared at a time when conspicuous numbers of women were extending their activities by campaigning for suffrage; working in factories, schools,…

  5. VizieR Online Data Catalog: VPHAS+ DR2 survey (Drew+, 2016)

    NASA Astrophysics Data System (ADS)

    Drew, J. E.; Gonzalez-Solares, E.; Greimel, R.; Irwin, M. J.; Kupcu Yoldas, A.; Lewis, J.; Barentsen, G.; Eisloffel, J.; Farnhill, H. J.; Martin, W. E.; Walsh, J. R.; Walton, N. A.; Mohr-Smith, M.; Raddi, R.; Sale, S. E.; Wright, N. J.; Groot, P.; Barlow, M. J.; Corradi, R. L. M.; Drake, J. J.; Fabregat, J.; Frew, D. J.; Gansicke, B. T.; Knigge, C.; Mampaso, A.; Morris, R. A. H.; Naylor, T.; Parker, Q. A.; Phillipps, S.; Ruhland, C.; Steeghs, D.; Unruh, Y. C.; Vink, J. S.; Wesson, R.; Zijlstra, A. A.

    2016-10-01

    The Second VPHAS data release (DR2) covers the first 21 months of data-taking in which the survey progressed to 24 percent completion. Much of the Galactic mid-plane is now covered (especially in the r, i and Hα filters). This images release supersedes DR1. The full description of the catalogue, including a discussion of how the catalogue was made and advice on best use of the data, is available as file vphas-dr2-desc.pdf (ftp://cdsarc.u-strasbg.fr/pub/cats/II/341/vphas-dr2-desc.pdf). The current photometric scale is linked to APASS in g, r and i, while the u and Hα bands are calibrated by local offsetting from g and r. For ESO archive entry, see ESO's public survey pages (http://eso.org/rm/publicAccess#/dataReleases). The catalogue was prepared by G. Barentsen, using respectively DAOPHOT and CASUTOOLS for the PSF and aperture photometry alternatives provided. The appropriate journal reference for the use of VPHAS+data is to: Drew et al., 2014MNRAS.440.2036D. If making use of data from this release, please use the following statement in the acknowledgements: "Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under public survey programme ID, 177.D-3023". (2 data files).

  6. Global transcriptome and physiological responses of Acinetobacter oleivorans DR1 exposed to distinct classes of antibiotics.

    PubMed

    Heo, Aram; Jang, Hyun-Jin; Sung, Jung-Suk; Park, Woojun

    2014-01-01

    The effects of antibiotics on environment-originated nonpathogenic Acinetobacter species have been poorly explored. To understand the antibiotic-resistance mechanisms that function in nonpathogenic Acinetobacter species, we used an RNA-sequencing (RNA-seq) technique to perform global gene-expression profiling of soil-borne Acinetobacter oleivorans DR1 after exposing the bacteria to 4 classes of antibiotics (ampicillin, Amp; kanamycin, Km; tetracycline, Tc; norfloxacin, Nor). Interestingly, the well-known two global regulators, the soxR and the rpoE genes are present among 41 commonly upregulated genes under all 4 antibiotic-treatment conditions. We speculate that these common genes are essential for antibiotic resistance in DR1. Treatment with the 4 antibiotics produced diverse physiological and phenotypic changes. Km treatment induced the most dramatic phenotypic changes. Examination of mutation frequency and DNA-repair capability demonstrated the induction of the SOS response in Acinetobacter especially under Nor treatment. Based on the RNA-seq analysis, the glyoxylate-bypass genes of the citrate cycle were specifically upregulated under Amp treatment. We also identified newly recognized non-coding small RNAs of the DR1 strain, which were also confirmed by Northern blot analysis. These results reveal that treatment with antibiotics of distinct classes differentially affected the gene expression and physiology of DR1 cells. This study expands our understanding of the molecular mechanisms of antibiotic-stress response of environment-originated bacteria and provides a basis for future investigations.

  7. State Environmental Policy Act (SEPA) Checklist for the 105-DR Large Sodium Fire Facility Closure Plan

    SciTech Connect

    Not Available

    1990-09-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, as well as for activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950's and is located in the 100-D Area of the Hanford Site. The building housed the DR defense reactor, which was shut down in 1964. The LSFF is subject to the regulatory requirements for the storage and treatment of dangerous wastes. Clean closure is the proposed method of closure for the LSFF. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610 (Ecology 1989). This closure plan presents a description of the facility, the history of wastes managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected.

  8. Advancing the Fundamental Understanding of Fission: 2014 LDRD 20120077DR Review

    SciTech Connect

    White, Morgan C.; Tovesson, Fredrik K.; Sierk, Arnold John

    2014-02-06

    The following slides were presented as part of the LDRD 20120077DR Progress Appraisal Review held Tuesday, February 4, 2014. This is part of an ongoing project assessment the previous of which was documented in LA-UR-13-21182. This presentation documents the progress made against the goals agreed to as part of the 2013 review.

  9. The first data release (DR1) of the LAMOST regular survey

    NASA Astrophysics Data System (ADS)

    Luo, A.-Li; Zhao, Yong-Heng; Zhao, Gang; Deng, Li-Cai; Liu, Xiao-Wei; Jing, Yi-Peng; Wang, Gang; Zhang, Hao-Tong; Shi, Jian-Rong; Cui, Xiang-Qun; Chu, Yao-Quan; Li, Guo-Ping; Bai, Zhong-Rui; Wu, Yue; Cai, Yan; Cao, Shu-Yun; Cao, Zi-Huang; Carlin, Jeffrey L.; Chen, Hai-Yuan; Chen, Jian-Jun; Chen, Kun-Xin; Chen, Li; Chen, Xue-Lei; Chen, Xiao-Yan; Chen, Ying; Christlieb, Norbert; Chu, Jia-Ru; Cui, Chen-Zhou; Dong, Yi-Qiao; Du, Bing; Fan, Dong-Wei; Feng, Lei; Fu, Jian-Ning; Gao, Peng; Gong, Xue-Fei; Gu, Bo-Zhong; Guo, Yan-Xin; Han, Zhan-Wen; He, Bo-Liang; Hou, Jin-Liang; Hou, Yong-Hui; Hou, Wen; Hu, Hong-Zhuan; Hu, Ning-Sheng; Hu, Zhong-Wen; Huo, Zhi-Ying; Jia, Lei; Jiang, Fang-Hua; Jiang, Xiang; Jiang, Zhi-Bo; Jin, Ge; Kong, Xiao; Kong, Xu; Lei, Ya-Juan; Li, Ai-Hua; Li, Chang-Hua; Li, Guang-Wei; Li, Hai-Ning; Li, Jian; Li, Qi; Li, Shuang; Li, Sha-Sha; Li, Xin-Nan; Li, Yan; Li, Yin-Bi; Li, Ye-Ping; Liang, Yuan; Lin, Chien-Cheng; Liu, Chao; Liu, Gen-Rong; Liu, Guan-Qun; Liu, Zhi-Gang; Lu, Wen-Zhi; Luo, Yu; Mao, Yin-Dun; Newberg, Heidi; Ni, Ji-Jun; Qi, Zhao-Xiang; Qi, Yong-Jun; Shen, Shi-Yin; Shi, Huo-Ming; Song, Jing; Song, Yi-Han; Su, Ding-Qiang; Su, Hong-Jun; Tang, Zheng-Hong; Tao, Qing-Sheng; Tian, Yuan; Wang, Dan; Wang, Da-Qi; Wang, Feng-Fei; Wang, Guo-Min; Wang, Hai; Wang, Hong-Chi; Wang, Jian; Wang, Jia-Ning; Wang, Jian-Ling; Wang, Jian-Ping; Wang, Jun-Xian; Wang, Lei; Wang, Meng-Xin; Wang, Shou-Guan; Wang, Shu-Qing; Wang, Xia; Wang, Ya-Nan; Wang, You; Wang, Yue-Fei; Wang, You-Fen; Wei, Peng; Wei, Ming-Zhi; Wu, Hong; Wu, Ke-Fei; Wu, Xue-Bing; Wu, Yu-Zhong; Xing, Xiao-Zheng; Xu, Ling-Zhe; Xu, Xin-Qi; Xu, Yan; Yan, Tai-Sheng; Yang, De-Hua; Yang, Hai-Feng; Yang, Hui-Qin; Yang, Ming; Yao, Zheng-Qiu; Yu, Yong; Yuan, Hui; Yuan, Hai-Bo; Yuan, Hai-Long; Yuan, Wei-Min; Zhai, Chao; Zhang, En-Peng; Zhang, Hua-Wei; Zhang, Jian-Nan; Zhang, Li-Pin; Zhang, Wei; Zhang, Yong; Zhang, Yan-Xia; Zhang, Zheng-Chao; Zhao, Ming; Zhou, Fang; Zhou, Xu; Zhu, Jie; Zhu, Yong-Tian; Zou, Si-Cheng; Zuo, Fang

    2015-08-01

    The Large sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signal-to-noise ratio (SNR) ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters: late A,FGK-type stars with high quality spectra (1061 918 entries), A-type stars (100 073 entries), and M-type stars (121 522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

  10. Connect the Book. Martin's Big Words: The Life of Dr. Martin Luther King, Jr.

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2005-01-01

    In honor of Martin Luther King, Jr. Day, this month's featured book is "Martin's Big Words: The Life of Dr. Martin Luther King, Jr." The book was written by Doreen Rappaport and illustrated by Bryan Collier (Jump at the Sun, 2001. 40p. ISBN 0786807148). This pictorial biography of the world-renowned civil rights leader has one of the most striking…

  11. Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

    ERIC Educational Resources Information Center

    Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

    2015-01-01

    Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the…

  12. HUCKLEBERRY FINN. DR. JEKYLL AND MR. HYDE. SHORT STORIES. LITERATURE CURRICULUM IV, STUDENT VERSION.

    ERIC Educational Resources Information Center

    KITZHABER, ALBERT R.

    A STUDENT'S CURRICULUM GUIDE FOR THE STUDY OF "HUCKLEBERRY FINN,""DR. JEKYLL AND MR. HYDE," AND THREE SHORT STORIES WAS PRESENTED. THE SHORT STORIES INCLUDED WERE (1) "THE COUNTRY OF THE BLIND" BY H.G. WELLS (COMPLETE TEXT), (2) "A DOUBLE-DYED DECEIVER" BY O. HENRY, AND (3) "A MYSTERY OF HEROISM"…

  13. HUCKLEBERRY FINN. DR. JEKYLL AND MR. HYDE. SHORT STORIES. LITERATURE CURRICULUM IV, TEACHER VERSION.

    ERIC Educational Resources Information Center

    KITZHABER, ALBERT R.

    A CURRICULUM GUIDE FOR THE TEACHING OF "HUCKLEBERRY FINN,""DR. JEKYLL AND MR. HYDE," AND FOUR SHORT STORIES WAS PRESENTED. THE SHORT STORIES WERE (1) "THE APPLE TREE" BY JOHN GALSWORTHY, (2) "THE COUNTRY OF THE BLIND" BY H.G. WELLS, (3) "A DOUBLE-DYED DECEIVER" BY O. HENRY, AND (4) "A MYSTERY…

  14. Why We Do Not Have Ethical Conduct: A Response to Dr. Sternberg

    ERIC Educational Resources Information Center

    Carson, Jamin

    2014-01-01

    In "We Need to Teach for Ethical Conduct," Dr. Robert Sternberg argued that students act unethically because they are unable to transfer principles of ethics into practice. While I agree that this is partially the case, it is also the case that unethical behavior is a result of the prevailing educational-philosophy: radical…

  15. Development and discrimination of 12 double ditelosomics in tetraploid wheat cultivar DR147.

    PubMed

    Li, Hao; Wang, Changyou; Fu, Shulan; Guo, Xiang; Yang, Baoju; Chen, Chunhuan; Zhang, Hong; Wang, Yajuan; Liu, Xinlun; Han, Fangpu; Ji, Wanquan

    2014-02-01

    As an important group in Triticum, tetraploid wheat plays a significant role in the research of wheat evolution. Several complete aneuploid sets of common wheat have provided valuable tools for genetic and breeding studies, while similar aneuploids of tetraploid wheat are still not well developed. Here, 12 double ditelosomics developed in Triticum turgidum L. var. durum cultivar DR147 (excluding dDT2B and dDT3A) were reported. Hybrids between DR147 and the original double-ditelosomic dDT2B of Langdon lost vigor and died prematurely after the three-leaf stage; therefore, the dDT2B line was not obtained. The cytogenetic behaviors and phenotypic characteristics of each line were detailedly described. To distinguish the entire chromosome complement of tetraploid wheat, the DR147 karyotype was established by fluorescence in situ hybridization (FISH), using the Aegilops tauschii clone pAsl and the barley clone pHvG38 as probes. FISH using a cereal-specific centromere repeat (6C6) probe suggested that all the lines possessed four telosomes, except for 4AS of double-ditelosomic dDT4A, which carried a small segment of the long arm. On the basis of the idiogram of DR147, these lines were successfully discriminated by FISH using the probes pAsl and pHvG38 and were then accurately designated.

  16. Dr. Wernher Von Braun on Tour With U.S. congressman Armistead Seldon

    NASA Technical Reports Server (NTRS)

    1999-01-01

    U.S. representative Armistead Seldon (D.-Al) tries on an astronaut maneuvering unit mockup during a tour of the Saturn I workshop at the Marshall Space Flight center. Explaining the unit and the workshop to Representative Seldon is Dr. Wernher Von Braun, director of the Marshall Center.

  17. Algebra Project DR K-12 Cohorts--Demonstration Project: Summative Evaluation Report

    ERIC Educational Resources Information Center

    St. John, Mark

    2014-01-01

    The Algebra Project DR K-12, funded by the National Science Foundation as a Research and Development Project, addressed the challenge of offering significant STEM content for students to ensure public literacy and workforce readiness. The project's primary purpose was to test the feasibility and effectiveness of a model for establishing four-year…

  18. Photographer: Digital Telepresence: Dr Murial Ross's Virtual Reality Application for Neuroscience

    NASA Technical Reports Server (NTRS)

    1995-01-01

    Photographer: Digital Telepresence: Dr Murial Ross's Virtual Reality Application for Neuroscience Research Biocomputation. To study human disorders of balance and space motion sickness. Shown here is a 3D reconstruction of a nerve ending in inner ear, nature's wiring of balance organs.

  19. Dr. Mary McLeod Bethune: A Life Devoted to Service

    ERIC Educational Resources Information Center

    Long, Kim Cliett

    2011-01-01

    The purpose of this paper is to explore and analyze the leadership traits of Dr. Mary McLeod Bethune, an African-American woman of history, using the servant leadership theory developed by Robert K. Greenberg and the ten characteristics of servant leadership as conceived by Larry C. Spears. This exploration seeks to identify the significant…

  20. Expression of MIF and CD74 in leukemic cell lines: correlation to DR expression destiny.

    PubMed

    Georgouli, Mirella; Papadimitriou, Lina; Glymenaki, Maria; Patsaki, Valia; Athanassakis, Irene

    2016-06-01

    Invariant chain (Ii) or CD74 is a non-polymorphic glycoprotein, which apart from its role as a chaperone dedicated to MHCII molecules, is known to be a high-affinity receptor for macrophage migration inhibitory factor (MIF). The present study aimed to define the roles of CD74 and MIF in the immune surveillance escape process. Towards this direction, the cell lines HL-60, Raji, K562 and primary pre-B leukemic cells were examined for expression and secretion of MIF. Flow cytometry analysis detected high levels of MIF and intracellular/membrane CD74 expression in all leukemic cells tested, while MIF secretion was shown to be inversely proportional to intracellular HLA-DR (DR) expression. In the MHCII-negative cells, IFN-γ increased MIF expression and induced its secretion in HL-60 and K562 cells, respectively. In K562 cells, CD74 (Iip33Iip35) was shown to co-precipitate with HLA-DOβ (DOβ), inhibiting thus MIF or DR binding. Induced expression of DOα in K562 (DOα-DOβ+) cells in different transfection combinations decreased MIF expression and secretion, while increasing surface DR expression. Thus, MIF could indeed be part of the antigen presentation process.

  1. Putting Functional Behavioral Assessment into Practice: A Conversation with Dr. Richard Van Acker.

    ERIC Educational Resources Information Center

    Bullock, Lyndal M.; Gable, Robert A.

    1999-01-01

    In this interview, Dr. Richard Van Acker discusses federal requirements for functional behavioral assessments (FBAs) and the teamwork involved in conducting an FBA. Various components of FBAs and the approximate time required are outlined and examples are provided of structured data collection for use in the FBA. (CR)

  2. Dr. Anna Julia Cooper, 1858-1964: Teacher, Scholar, and Timeless Womanist

    ERIC Educational Resources Information Center

    Giles, Mark S.

    2006-01-01

    The study examines the various accomplishments and achievements of Dr. Anna Julia Cooper, a social activist-educator, scholar and an early model for African-American feminist theory. Cooper was a great public intellectual and teacher, as she highly attacked the prevalence of racism, sexism and poverty through her writings and by working with…

  3. African American Women Scholars and International Research: Dr. Anna Julia Cooper's Legacy of Study Abroad

    ERIC Educational Resources Information Center

    Evans, Stephanie Y.

    2009-01-01

    EIn this article, the author presents a little-known but detailed history of Black women's tradition of study abroad. Specifically, she situates Dr. Anna Julia Cooper within the landscape of historic African American students who studied in Japan, Germany, Jamaica, England, Italy, Haiti, India, West Africa, and Thailand, in addition to France. The…

  4. Dr. Richard D. Gragg III to Receive Third Place Gulf Guardian Award in the Individual Category

    EPA Pesticide Factsheets

    ATLANTA - Today, the Gulf of Mexico Program announced that Dr. Richard D. Schulterbrandt Gragg III will receive a Third Place 2015 Gulf Guardian Award in the Individual Category. The award will be given tonight at an awards ceremony at the Texas State Aqua

  5. VizieR Online Data Catalog: Be stars in LAMOST DR1 (Lin+, 2015)

    NASA Astrophysics Data System (ADS)

    Lin, C.-C.; Hou, J.-L.; Chen, L.; Shao, Z.-Y.; Zhong, J.; Yu, P.-C.

    2015-11-01

    We describe a search for CBes using LAMOST DR1. A total of 192 (with 12 previously known CBes) objects were identified as CBes with prominent HeI λ 4387, HeI λ4471 and MgII λ4481 absorption lines, as well as Hβλ4861 and Hαλ6563 emission lines. (2 data files).

  6. In response to Dr. Jose AP da Silva: fall prevention with vitamin D clarifications needed

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We agree with Dr. da Silva, and wish to clarify three issues raised by the recent IOM report concerning our 2009 meta-analysis on vitamin D and fall prevention. 1. The IOM questioned the inclusion of Broe et al., which did not pre-specify falls as a primary or secondary outcome. While this did viol...

  7. The Research of Dr. Joanne Simpson: Fifty Years Investigating Hurricanes, Tropical Clouds and Cloud Systems

    NASA Technical Reports Server (NTRS)

    Tao, W. -K.; Halverson, J.; Adler, R.; Garstang, M.; Houze, R., Jr.; LeMone, M.; Pielke, R., Sr.; Woodley, W.; O'C.Starr, David (Technical Monitor)

    2001-01-01

    This AMS Meteorological Monographs is dedicated to Dr. Joanne Simpson for her many pioneering research efforts in tropical meteorology during her fifty-year career. Dr. Simpson's major areas of scientific research involved the "hot tower" hypothesis and its role in hurricanes, structure and maintenance of trade winds, air-sea interaction, and observations and the mechanism for hurricanes and waterspouts. She was also a pioneer in cloud modeling with the first one-dimensional model and had the first cumulus model on a computer. She also played a major role in planning and leading observational experiments on convective cloud systems. The launch of the Tropical Rainfall Measuring Mission (TRMM) satellite, a joint U.S.-Japan project, in November of 1997 made it possible for quantitative measurements of tropical rainfall to be obtained on a continuous basis over the entire global tropics. Dr. Simpson was the TRAM Project Scientist from 1986 until its launch in 1997. Her efforts during this crucial period ensured that the mission was both well planned scientifically and well engineered as well as within budget. In this paper, Dr. J. Simpson's nine specific accomplishments during her fifty-year career: (1) hot tower hypothesis, (2) hurricanes, (3) airflow and clouds over heated islands, (4) cloud models, (5) trade winds and their role in cumulus development, (6) air-sea interaction, (7) cloud-cloud interactions and mergers, (8) waterspouts, and (9) TRMM science, will be described and discussed.

  8. Dr. Strangelove: Or How I Learned To Stop Worrying and Teach the Film in the Classroom.

    ERIC Educational Resources Information Center

    Lowery, J. Vincent

    2002-01-01

    Presents a lesson plan focusing on the film, "Dr. Strangelove" by Stanley Kubrick, and describes the film in detail. Reviews the historical background about the film to assist students in understanding the themes presented. Discusses the characters in the film and their possible real-life counterparts. (CMK)

  9. A white horse in the desert: The life of Dr Thomas Somerville (1887-1941).

    PubMed

    Watkins, P E

    2017-02-01

    This article details the remarkable life of Dr Thomas Somerville, who qualified both as a veterinary surgeon and medical practitioner, served in two world wars and was recommended for the nation's highest award for gallantry. In doing so, it records the life of a man whose repeated gallantry on the battlefield has been overlooked.

  10. Report on Sabbatical activities - Dr. Ronnie Shepherd - 05/25/2014 to 08/21/2014

    SciTech Connect

    Shepherd, Ronnie

    2014-10-09

    The sabbatical performed by Dr. Ronnie Shepherd from 05/25/2014 to 08/21/2014 had two central goals: 1) write three proposals for future collaborative experiments at Ecole Polytechnique (and possibly LLNL) 2) if laser time was granted (based on the proposal), perform a preliminary experiment in preparation for the campaign of laser time based on proposal submission.

  11. Identification of amino acids in the Dr adhesin required for binding to decay-accelerating factor.

    PubMed

    Van Loy, Cristina P; Sokurenko, Evgeni V; Samudrala, Ram; Moseley, Steve L

    2002-07-01

    Members of the Dr family of adhesins of Escherichia coli recognize as a receptor the Dr(a) blood-group antigen present on the complement regulatory and signalling molecule, decay-accelerating factor (DAF). One member of this family, the Dr haemagglutinin, also binds to a second receptor, type IV collagen. Structure/function information regarding these adhesins has been limited and domains directly involved in the interaction with DAF have not been determined. We devised a strategy to identify amino acids in the Dr haemagglutinin that are specifically involved in the interaction with DAF. The gene encoding the adhesive subunit, draE, was subjected to random mutagenesis and used to complement a strain defective for its expression. The resulting mutants were enriched and screened to obtain those that do not bind to DAF, but retain binding to type IV collagen. Individual amino acid changes at positions 10, 63, 65, 75, 77, 79 and 131 of the mature DraE sequence significantly reduced the ability of the DraE adhesin to bind DAF, but not collagen. Over half of the mutants obtained had substitutions within amino acids 63-81. Analysis of predicted structures of DraE suggest that these proximal residues may cluster to form a binding domain for DAF.

  12. MSFC Director Dr. Jerroll W. Littles with President Clinton in Oval office.

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Marshall's eighth Center Director Dr. Jerroll W. Littles (1996-1998) and his wife are pictured with President Bill Clinton in the Oval Office of the White House following the presentation of the Presidential Rank Award for Distinguished Service. Other NASA honorees and their spouses are also pictured.

  13. Dr. Wernher Von Braun at the Marshall Space Flight Center's neutral buoyancy simulator.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, Marshall Space Flight Center director, points and asks a question about the operation of the center's neutral buoyancy facility in the Manufacturing Engineering Laboratory. The facility was used to test and evaluate hardware and operations hat were planned for Apollo applications program flights.

  14. Narrating International and National Trends in US Science Education: An Autobiographical Approach Showcasing Dr. Robert Yager

    ERIC Educational Resources Information Center

    Verma, Geeta; Martin-Hansen, Lisa

    2009-01-01

    This biographical piece is based on a conversation involving Bob Yager, Geeta Verma, and Lisa Martin-Hansen which took place at the National Association for Research in Science Teaching (NARST) conference in March, 2008. The unique aspect of this autobiographical piece is that it highlights Dr. Yager's account about the emergence of the science…

  15. Interview with a quality leader: Dr. David Nash. Interviewed by Kathleen Tornow Chai.

    PubMed

    Nash, David B

    2013-01-01

    Dr. David Nash, founder of the original Office of Health Policy in 1990 at Thomas Jefferson University and later the Founding Dean of the Jefferson School of Population Health, is known for his emphasis on measurement and variation in Medical Education. His knowledge and understanding of healthcare policy make this interview timely and relevant.

  16. It Really Is All about the Child: An Interview with Dr. Edward Hallowell

    ERIC Educational Resources Information Center

    Peters, Dane L.

    2012-01-01

    In a decade when brain research has helped people understand learning difficulties in children, and people have seen increased media attention on the use of medications to treat attention deficit/hyperactivity disorder (ADHD) in children and adults, Dr. Edward (Ned) Hallowell has worked tirelessly to educate the medical profession, parents,…

  17. Dr. Bruce Squires witnessed vast changes during tenure as CMAJ editor

    PubMed Central

    Sullivan, Patrick

    1996-01-01

    Dr. Bruce Squires retired in September after spending 10 years as editor of CMAJ. During his tenure the editor's responsibilities expanded greatly because of the CMA's foray into the publishing of medical books and additional journals and other publications. In this article, people who have worked with Squires reflect on his term with CMAJ. Imagesp570-a

  18. If Dr. King Were a Principal: Building the "Beloved Community" in Schools

    ERIC Educational Resources Information Center

    Hillis, Michael; Woolworth, Stephen

    2008-01-01

    In this article, the authors offer a more humanistic vision of educational community, one that is substantive in content yet flexible in its application to the diverse contexts in which American schooling occurs. In doing so, the authors turn specifically to the nonviolent philosophy of Dr. Martin Luther King, Jr. and consider what a school…

  19. Hospital Ship Replacement

    DTIC Science & Technology

    2011-08-01

    designed to operate primarily when anchored to reduce the effects of roll. Quantum markets two separate zero speed active roll fin models for small ...ships. Feasibility of scaling fins to the size of the hospital ship requires validation. 3.12 Lifeboats and Liferafts The safety appliances designated ...for Innovation in Ship Design Technical Report Hospital Ship Replacement By Hannah Allison, Christopher Mehrvarzi, Rebecca Piks, Beau Lovdahl

  20. Fast tracking hospital construction.

    PubMed

    Quirk, Andrew

    2013-03-01

    Hospital leaders should consider four factors in determining whether to fast track a hospital construction project: Expectations of project length, quality, and cost. Whether decisions can be made quickly as issues arise. Their own time commitment to the project, as well as that of architects, engineers, construction managers, and others. The extent to which they are willing to share with the design and construction teams how and why decisions are being made.