Historia Verdadera del Chicano del Norte. [True History of the Chicano of the North].

ERIC Educational Resources Information Center

Herrera, David; Bryan, Clifford E.

Very little is known about the Chicanos in the northern U.S., especially those in the Northwest. Research and writing on Chicanos have concentrated on the Southwest or large urban settings, thus excluding those Chicanos residing in rural settings except for those in the migrant stream. These rural residents have become a forgotten people,…

You can see galaxies from your computer | CTIO

Science.gov Websites

Calendar Activities NOAO-S EPO Programs CADIAS Astro Chile Hugo E. Schwarz Telescope Dark Sky Education Preserving the Dark Skies La Oficina de Protección de la Calidad del Cielo del Norte de Chile - OPCC Light Pollution StarLight Universe The World at Night (TWAN) International Dark-Sky Association (IDA) Students REU

Rio Grande del Norte National Conservation Area Establishment Act

THOMAS, 111th Congress

Sen. Bingaman, Jeff [D-NM

2009-04-23

Senate - 03/02/2010 Placed on Senate Legislative Calendar under General Orders. Calendar No. 285. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Rio Grande del Norte National Conservation Area Establishment Act

THOMAS, 112th Congress

Sen. Bingaman, Jeff [D-NM

2011-03-29

Senate - 01/13/2012 Placed on Senate Legislative Calendar under General Orders. Calendar No. 275. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

76 FR 8333 - Del Norte Resource Advisory Committee (RAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-14

..., 301 West Washington Boulevard, Crescent City, California 95531. FOR FURTHER INFORMATION CONTACT: Adam... solicitations and will vote on projects to recommend for funding. The meeting is open to the public and there...

2. WILLITS SIGN. GATEWAY TO THE REDWOODS. WILLITS, MENDOCINO COUNTY, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. WILLITS SIGN. GATEWAY TO THE REDWOODS. WILLITS, MENDOCINO COUNTY, CALIFORNIA. LOOKING NW. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

67. WILLITS SIGN. GATEWAY TO THE REDWOODS. WILLITS, MENDOCINO COUNTY, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

67. WILLITS SIGN. GATEWAY TO THE REDWOODS. WILLITS, MENDOCINO COUNTY, CALIFORNIA. LOOKING NW. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

Evaluation of LIDAR for landslide mapping.

DOT National Transportation Integrated Search

2006-06-01

The Caltrans GeoResearch Group, in collaboration with the Department of Conservation, successfully : used LIDAR technology to map landslides along two heavily forested highway corridors in Humboldt : and Del Norte Counties. LIDAR (Light Detection ...

75 FR 11104 - Del Norte Resource Advisory Committee (RAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... Schools and Community Self-Determination Act (Pub. L. 110-343) and in compliance with the Federal Advisory...; (4) discussion of Committee member and Designated Federal Official roles and (5) review operational...

5. TUNNEL TREE AT DRIVETHROUGHTREE PARK. LEGGETT, HUMBOLDT COUNTY, CALIFORNIA. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. TUNNEL TREE AT DRIVE-THROUGH-TREE PARK. LEGGETT, HUMBOLDT COUNTY, CALIFORNIA. LOOKING NE. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

22. EXTERIOR DETAIL VIEW OF SOUTHEAST CORNER OF BRIDGE, 1932 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. EXTERIOR DETAIL VIEW OF SOUTHEAST CORNER OF BRIDGE, 1932 SECTION, SOUTH BANK, LOOKING NORTHEAST TO SOUTHWEST - Rowdy Creek Bridge, Spanning Rowdy Creek at Fred Haight Drive, Smith River, Del Norte County, CA

76 FR 13124 - Del Norte Resource Advisory Committee (RAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-10

...: Adam Dellinger, Committee Coordinator, Six Rivers National Forest, at (707) 441-3569; e-mail adellinger... recommended projects and will vote on projects to recommend for funding. The meeting is open to the public and...

CTIO History | CTIO

Science.gov Websites

Preserving the Dark Skies La Oficina de Protección de la Calidad del Cielo del Norte de Chile - OPCC Light Pollution StarLight Universe The World at Night (TWAN) International Dark-Sky Association (IDA) Students REU ‹› You are here CTIO Home » About » CTIO History CTIO History Brief History of THE CERRO

37. BRIDGE 115, SMITH RIVER MIDDLE FORK OREGON STATE HIGHWAY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

37. BRIDGE 1-15, SMITH RIVER MIDDLE FORK OREGON STATE HIGHWAY 199. JOSEPHINE COUNTY, OREGON. LOOKING SSW. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

40. CAVEMAN BRIDGE, ROGUE RIVER, OREGON STATE HIGHWAY 199. GRANTS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. CAVEMAN BRIDGE, ROGUE RIVER, OREGON STATE HIGHWAY 199. GRANTS PASS, JOSEPHINE COUNTY, OREGON. LOOKING S. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

39. CAVEMAN BRIDGE, ROGUE RIVER, OREGON STATE HIGHWAY 199. GRANTS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

39. CAVEMAN BRIDGE, ROGUE RIVER, OREGON STATE HIGHWAY 199. GRANTS PASS, JOSEPHINE COUNTY, OREGON. LOOKING SW. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

1. HEALDSBURG BRIDGE, OLD HIGHWAY 101, ACROSS THE RUSSIAN RIVER. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. HEALDSBURG BRIDGE, OLD HIGHWAY 101, ACROSS THE RUSSIAN RIVER. HEALDSBURG, MEDDOCINO COUNTY, CALIFORNIA. LOOKING NW. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

Remediation System Evaluation, Summitville Mine Superfund Site

EPA Pesticide Factsheets

The Summitville Mine Superfund Site is located in the southeastern portion of the San Juan Mountains,in Rio Grande County, approximately 60 miles west of Alamosa, Colorado and 10 to 15 miles south ofDel Norte, Colorado.

27. AVENUE OF THE GIANTS SIGN AT NORTH END OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. AVENUE OF THE GIANTS SIGN AT NORTH END OF ROAD. PEPPERWOOD, HUMBOLDT COUNTY, CALIFORNIA. LOOKING S. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

36. MYRTLE CREEK BRIDGE, OREGON STATE HIGHWAY 199, AT END ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

36. MYRTLE CREEK BRIDGE, OREGON STATE HIGHWAY 199, AT END OF STOUT GROVE ROAD. JOSEPHINE COUNTY, OREGON LOOKING WNW. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

71. MYRTLE CREED BRIDGE, OREGON STATE HIGHWAY 199, AT END ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

71. MYRTLE CREED BRIDGE, OREGON STATE HIGHWAY 199, AT END OF STOUT GROVE ROAD. JOSEPHINE COUNTY, OREGON. LOOKING WNW. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

PASO DEL NORTE ENVIRONMENTAL MONITOR

EPA Science Inventory

This project is developing an Internet web site and associated community linkages to provide relevant-time air quality and local traffic and transit information, in English and Spanish, to the international communities of El Paso, Texas, Sunland Park, New Mexico and Ciud...

48. Photographer unknown February 1925 MENDOCINO COUNTY, SECTION K, HIGHWAY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

48. Photographer unknown February 1925 MENDOCINO COUNTY, SECTION K, HIGHWAY 1. 1-MEN-1-K #39, LOG GUARD RAIL, 2-25. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

12. VIEW, LOOKING NORTHWEST, ALONG CENTERLINE FROM NORTH CANTILEVER TOWER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. VIEW, LOOKING NORTHWEST, ALONG CENTERLINE FROM NORTH CANTILEVER TOWER TOWARD SOUTH PORTAL. As with previous photo, note vertical displacement in deck. - Smith River Bridge, CA State Highway 199 Spanning Smith River, Crescent City, Del Norte County, CA

Site Description | CTIO

Science.gov Websites

Preserving the Dark Skies La Oficina de Protección de la Calidad del Cielo del Norte de Chile - OPCC Light view Cerro Pachón CTIO/AURA La Serena Facilities The "El Totoral" Reserve, Cerro Tololo and . back to top Sky Brightness over Cerro Pachón and Cerro Tololo Light pollution from nearby cities (La

54. Photographer unknown February 1925 HUMBOLDT COUNTY, SECTION J, HIGHWAY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

54. Photographer unknown February 1925 HUMBOLDT COUNTY, SECTION J, HIGHWAY 1. HUM-1-J #34, SINKS ALONG HIGH. NEAR OCEAN, 2-25. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

38. LANDSCAPE HIGHWAY VIEW, OREGON STATE HIGHWAY 199. JOSPHINE COUNTY, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

38. LANDSCAPE HIGHWAY VIEW, OREGON STATE HIGHWAY 199. JOSPHINE COUNTY, OREGON. REEVES CREEK (WHERE ROAD WIDENS) 4 MILES NE OF CAVE JUNCTION. LOOKING S. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

52. G.E.H. photographer August 1930 1HUM1B #59, OILING OPERATIONS, GEH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

52. G.E.H. photographer August 1930 1-HUM-1-B #59, OILING OPERATIONS, GEH 8-30. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

Environmentally friendly elimination of moss from open-graded asphalt pavement.

DOT National Transportation Integrated Search

2011-04-01

Caltrans has discovered moss growing on U.S. Highway 101 in Del Norte and Humboldt counties, U.S. : Highway 199 near the Smith River and other roadways in Caltrans District 1. These areas are heavily : forested, and the heavy tree canopies shielding ...

75 FR 78966 - Del Norte Resource Advisory Committee (RAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-17

... Washington Boulevard, Crescent City, California 95531. FOR FURTHER INFORMATION CONTACT: Adam Dellinger..., the public will present clarification on previously submitted Title II project proposals to the RAC. The RAC will vote on projects to recommend for funding. There will also be a public comment...

56. Photographer unknown February 1925 HUMBOLDT COUNTY, SECTION J, HIGHWAY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

56. Photographer unknown February 1925 HUMBOLDT COUNTY, SECTION J, HIGHWAY 1. HUM-1-J #36, SINKS ALONG OCEAN SHORE, 2-25. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

Geology and depositional environments of the Guadalupian rocks of the northern Del Norte Mountains, West Texas

USGS Publications Warehouse

Rudine, S.F.; Wardlaw, B.R.; Rohr, D.M.; Grant, R.E.

2000-01-01

The Guadalupian rocks of the northern Del Norte Mountains were deposited in a foreland basin between land of the Marathon orogen and a carbonate shoal established on the geanticline separating the foreland basin from the Delaware basin. Deposition was alternately influenced by coarse clastic input from the orogen and carbonate shoal, which interrupted shallow basinal siltstone depletion. Relatively deeper-water deposition is characterized by carbonate input from the shoal, and relatively shallow-water deposition is characterized by sandstone input from the orogen. Deposition was in five general transgressive-regressive packages that include (1) the Road Canyon Formation and the first siltstone member and first sandstone member of the Word Formation, (2) the second siltstone member, Appel Ranch Member, and limy sandy siltstone member of the Word Formation, (3) the Vidrio Formation, (4) the lower and part of the middle members of the Altuda Formation, and (5) part of the middle and upper members of the Altuda Formation.

Maritime Factors Affecting Iberian Security,

DTIC Science & Technology

1980-10-01

afirme/ que para las sovie’ticas una campaiia en gran escala dirigida contra las comunicaciones marftimas del Atlantica Norte durante el perfada inicial...defender sus l ’neas de comunicacion maritima; y cuarta -- y a mi parecer la consideracion mas importante -- las otras tareas que la marina de guerra

Estructura y química del suelo en un bosque de Castilla elastica en el carso del norte de Puerto Rico: resultados de una calicata

Treesearch

Christian A. Viera Martinez; Oscar Abelleira; Ariel E. Lugo

2008-01-01

We dug a soil pit of 1m x 1m x 1m in a forest dominated by Castilla elastica, a tree for shade coffee introduced in the karst of northern Puerto Rico. We found four soil horizons (designation notes in parenthesis) (A) organic soil matter (E) mineral soil leachate (B) aerobic mineral soil, and (C) saturated soil. The total storage of soil organic matter was 143 Mg/ha....

Philippine Classroom Teachers as Researchers: Teachers' Perceptions, Motivations, and Challenges

ERIC Educational Resources Information Center

Ulla, Mark B.; Barrera, Kenneth Ian B.; Acompanado, Meller M.

2017-01-01

This study explores teachers' perceptions and motivations, challenges, and needs of 50 teachers in Agusan del Norte, Philippines with regards to doing research. Methodologies used were survey questionnaire, and group and individual interviews. Findings revealed that teacher-respondents had a positive perceptions towards doing research and its…

77 FR 20690 - Environmental Impact Statement: Albuquerque, New Mexico

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-05

...: Albuquerque, New Mexico AGENCY: Federal Highway Administration (FHWA), USDOT. ACTION: Rescind Notice of Intent... proposed improvements to the Interstate 25 and Paseo del Norte Interchange in Albuquerque, New Mexico. FOR... Mexico Division, 4001 Office Court Drive, Suite 801, Santa Fe, New Mexico 87507, Telephone (505) 820-2027...

57. G.M.W., photographer March 26, 1940 HUMBOLDT COUNTY, SECTION K, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

57. G.M.W., photographer March 26, 1940 HUMBOLDT COUNTY, SECTION K, HIGHWAY 1. HUM-1-K #93, STA. 255, 3-26-40, G.M.W. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

11. VIEW, LOOKING SOUTHEAST, ALONG CENTERLINE FROM SOUTH CANTILEVER TOWARD ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. VIEW, LOOKING SOUTHEAST, ALONG CENTERLINE FROM SOUTH CANTILEVER TOWARD TOWARD NORTH PORTAL. Note vertical displacement in deck caused by partial collapse at point of connection between south cantilever arm and suspended span. - Smith River Bridge, CA State Highway 199 Spanning Smith River, Crescent City, Del Norte County, CA

46. C.P.S., photographer March 1936 MENDOCINO COUNTY, SECTION, HIGHWAY 1. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. C.P.S., photographer March 1936 MENDOCINO COUNTY, SECTION, HIGHWAY 1. MEN-1-J#135, 384+50 81TTC2, LOOKING SOUTH LANES FLAT, C.P.S., 36. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

1. CONTEXTUAL VIEW OF BRIDGE IN SETTING, LOOKING SOUTHWEST, FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. CONTEXTUAL VIEW OF BRIDGE IN SETTING, LOOKING SOUTHWEST, FROM DOWNSTREAM. Crew, vehicles, boats, and equipment are from the California Department of Transportation's Transportation Laboratory conducting test borings for the replacement bridge. - Smith River Bridge, CA State Highway 199 Spanning Smith River, Crescent City, Del Norte County, CA

77 FR 47360 - Del Norte Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-08

... Community Self-Determination Act (Pub. L. 112-141) (the Act) and operates in compliance with the Federal... provide advice and recommendations to the Forest Service concerning projects and funding consistent with... 2011 project status and to discuss process the Committee will use to review and recommend fiscal year...

The timber resources of Humboldt County, California.

Treesearch

Daniel D. Oswald

1968-01-01

This report presents the first complete inventory of Humboldt County's timber resources. Past Forest Survey inventories have included Humboldt County, but they were not designed to obtain volume estimates for an individual county. Humboldt County is part of a survey unit which also includes Del Norte County. There are eight such inventory units in California; and...

45. C.P.S., photographer January 1936 MENDOCINO COUNTY, SECTION, HIGHWAY 1. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. C.P.S., photographer January 1936 MENDOCINO COUNTY, SECTION, HIGHWAY 1. MEN-I-J #132, 388+00 81TTC2, LOOKING SOUTH LANES FLAT, C.P.S., 1-36. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

59. V.H.G., photographer October 27, 1948 EUREKA, HUMBOLDT COUNTY, HIGHWAY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

59. V.H.G., photographer October 27, 1948 EUREKA, HUMBOLDT COUNTY, HIGHWAY 1. HUM-1-EUR #59, LOOKING NORTH BROADWAY & CEDAR, 10-27-48, V.H.G. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

58. V.H.G., photographer October 27, 1948 EUREKA, HUMBOLDT COUNTY, HIGHWAY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

58. V.H.G., photographer October 27, 1948 EUREKA, HUMBOLDT COUNTY, HIGHWAY 1. HUM-1-EUR #60, LOOKING SOUTH, BROADWAY & CLARK, 10-27-48, V.H.G. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

75 FR 71732 - Proposed Finding Against Federal Acknowledgment of the Tolowa Nation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

... ancestors were involved in interaction indicative of a social community, but does not to show that they... social interaction. Researchers also consulted BIA enrollments conducted by Henry Roe Cloud in 1939. The... Rancherias in 1906, 1908, and 1938 respectively; and Federal interaction with the Del Norte Indian Welfare...

47. N.R.P., photographer January 14, 1938 MENDOCINO COUNTY, SECTION, HIGHWAY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. N.R.P., photographer January 14, 1938 MENDOCINO COUNTY, SECTION, HIGHWAY 1. 1-MEN-1-J #144, ROCK CREEK BRIDGE. SO., 1-14-38, N.R.P. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

78 FR 50025 - Del Norte County Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-16

... authorized under the Secure Rural Schools and Community Self-Determination Act (Act) (Pub. L. 112-141) and... Service concerning projects and funding consistent with the Title II of the Act. The meetings are open to the public. The purpose of the meetings are to review prior year project's progress and to review and...

Modified team-based learning strategy to improve human anatomy learning: A pilot study at the Universidad del Norte in Barranquilla, Colombia.

PubMed

Martínez, Emilio G; Tuesca, Rafael

2014-01-01

As part of an institutional program sponsored by the Centre for Teaching Excellence at the Universidad del Norte, Barranquilla, Colombia, we developed an educational research study on two sessions of human anatomy in which we combined team-based learning (TBL) and the use of iPads. Study data included the TBL, assessments applied during the course, student's grades on mid-term examinations and students' perceptions of their experiences. Students reported a positive attitude toward the use of the TBL sessions, and the results showed a significant improvement in their learning between the first and second sessions. Significantly positive correlations (P < 0.05) were obtained between (a) the individual students' readiness test performance 1 and mid-term examination 1, (b) the individual readiness test performances from Session 1 to Session 2, and (c) the group readiness test performances from the first and second sessions. These results point to positive learning experiences for these students. Analyses of the students' reflections on their activities also pointed toward future challenges. © 2014 American Association of Anatomists.

Aryl hydrocarbon receptor-mediated activity of particulate organic matter from the Paso del Norte airshed along the U.S.-Mexico border.

PubMed Central

Arrieta, Daniel E; Ontiveros, Cynthia C; Li, Wen-Whai; Garcia, Jose H; Denison, Michael S; McDonald, Jacob D; Burchiel, Scott W; Washburn, Barbara Shayne

2003-01-01

In this study, we determined the biologic activity of dichloromethane-extracted particulate matter < 10 micro m in aerodynamic diameter (PM10) obtained from filters at three sites in the Paso del Norte airshed, which includes El Paso, Texas, USA; Juarez, Chihuahua, Mexico, and Sunland Park, New Mexico, USA. The extracts were rich in polycyclic aromatic hydrocarbons (PAHs) and had significant biologic activity, measured using two in vitro assay systems: ethoxyresorufin-(O-deethylase (EROD) induction and the aryl hydrocarbon-receptor luciferase reporter system. In most cases, both EROD (5.25 pmol/min/mg protein) and luciferase activities (994 relative light units/mg) were highest in extracts from the Advance site located in an industrial neighborhood in Juarez. These values represented 58% and 55%, respectively, of induction associated with 1 micro M ss-naphthoflavone exposures. In contrast, little activity was observed at the Northeast Clinic site in El Paso, the reference site. In most cases, luciferase and EROD activity from extracts collected from the Tillman Health Center site, situated in downtown El Paso, fell between those observed at the other two sites. Overall, a statistically significant correlation existed between PM10 and EROD and luciferase activities. Chemical analysis of extracts collected from the Advance site demonstrated that concentrations of most PAHs were higher than those reported in most other metropolitan areas in the United States. Calculations made with these data suggest a cancer risk of 5-12 cases per 100,000 people. This risk estimate, as well as comparisons with the work of other investigators, raises concern regarding the potential for adverse health effects to the residents of this airshed. Further work is needed to understand the sources, exposure, and effects of PM10 and particulate organic material in the Paso del Norte airshed. PMID:12896850

Individual-based model formulation for cutthroat trout, Little Jones Creek, California

Treesearch

Steven F. Railsback; Bret C. Harvey

2001-01-01

This report contains the detailed formulation of an individual-based model (IBM) of cutthroat trout developed for three study sites on Little Jones Creek, Del Norte County, in northwestern California. The model was designed to support research on relations between habitat and fish population dynamics, the importance of small tributaries to trout populations, and the...

78 FR 18783 - Establishment of the R[iacute]o Grande del Norte National Monument

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

... the landscape by the remnants of homes, root cellars, cistern-style water catchments, and cast metal... management of the objects to be protected; WHEREAS it is in the public interest to preserve the objects of... approximately 242,555 acres, which is the smallest area compatible with the proper care and management of the...

Prioritizing treatment of second-growth forests using LiDAR

Treesearch

Lathrop P. Leonard; Daryl Van Dyke

2012-01-01

We used multi-return light detecting and ranging (LiDAR) to develop a costeffective method for describing forest conditions and prioritizing stands for treatment in over 14,000 ha of second-growth forests (11 to 85 years old) in Del Norte Coast Redwoods State Park (DNCRSP). DNCRSP consists primarily of redwood and Douglas-fir dominated forests with scattered tanoak...

Timber resource statistics for the North Coast resource area of California 1994.

Treesearch

Karen L. Waddell; Patricia M. Bassett

1996-01-01

This report is a summary of timber resource statistics for the North Coast Resource Area of California, which includes Del Norte, Humboldt, Mendocino, and Sonoma Counties. Data were collected by the Pacific Northwest Research Station as part of a State-wide multi-resource inventory. The inventory sampled private and public lands except reserved areas and National...

Final Supplemental Environmental Assessment: Falcon I Launch Vehicle Program from SLC-4W Vandenberg Air Force Base, California

DTIC Science & Technology

2005-09-06

affected surface water, 3) adversely affected groundwater quantity or quality, or 4) caused a need that exceeded the existing potable supply or...goby is from Tillas Slough (mouth of the Smith River) in Del Norte County, south to Colonel Louis D. Van Mullem, Jr. (1-8-96-F/C-29) 5 Agua Hedionda

Breeding distribution of the marbled murrelet in Redwood National Park and vicinity during 1988

Treesearch

C. John Ralph; Peter W. C. Paton; Aivars Zakis; Gary Strachan

1990-01-01

We report on an intensive research effort to determine the present status of the marbled murrelet (Brachyramphus marmoratus) in the vicinity of Redwood National Park, in Del Norte and northern Humboldt Counties, California. This seabird is primarily an inhabitant of the nearshore waters and adjacent coastal redwood forests of the northern half of the...

77 FR 39413 - Safety Zone: Crescent City Fourth of July Fireworks Event, Crescent City, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

...-AA00 Safety Zone: Crescent City Fourth of July Fireworks Event, Crescent City, CA AGENCY: Coast Guard... the navigable waters near Crescent City Harbor in Crescent City, CA in support of the Crescent City... establish safety zones (33 U.S.C sections 1221 et seq.). Crescent City-Del Norte County Chamber of Commerce...

Timber resource statistics of the north coast resource area of California.

Treesearch

J.D. Lloyd; Joel Moen; Charles L. Bolsinger

1986-01-01

This report is one of five that provide timber resource statistics for 57 of the 58 counties in California (San Francisco is excluded). This report presents statistics from a 1981-84 inventory of the timber resources of Del Norte, Humboldt, Mendocino, and Sonoma Counties. Tables presented are of forest area and of timber volume, growth, and mortality. The north coast...

Ozone studies in the Paso del Norte region

NASA Astrophysics Data System (ADS)

Becerra-Davila, Fernando

The Paso del Norte region forms the largest contiguous bi-national conglomerate on the US-Mexico border. With a combined population of around 2 million inhabitants, the Paso del Norte region is isolated, more than 500 km away from the nearest urban area of comparable size, thus making it an ideal location for air quality studies of an isolated urban environment. The meteorological conditions leading to a high ozone episode in this region, such as the historical ozone episode of June 2006, are analyzed. It is well known that stagnation and minimal winds, high temperatures, and pressure ridges over the region are conducive to high ozone episodes. In addition, the planetary boundary height is studied to understand its impact on high ozone episodes. Several studies report that ground level ozone non-attainment regulations could be caused not only by local emissions, but also by atmospheric transport. In this work the atmospheric advection of pollutants into the region is analyzed using HYSPLIT backward trajectories. Furthermore, a novel backward trajectory clustering technique is implemented for the summer of 2006. The "ozone weekend effect" (OWE) is a phenomenon by which in some geographical regions ambient ozone concentrations tend to be higher on weekends than on weekdays, despite the lower emissions of ozone precursors during those days. The observed local OWE has never previously been studied in terms of the photolysis rates of four of the main ozone precursors. In this research a novel method that allows the calculation of actinic fluxes, photolysis frequencies and photolysis rates with a high degree of accuracy and reliability has been developed. This method utilizes a combination of the experimental data available for this region in conjunction with a radiative transfer model (TUV model). Three weekend-weekday cases during summers 2006, 2009 and 2010 are studied in this work. In this research, the photolysis impact on the local OWE is studied. The results obtained from this photolysis study demonstrate that the local ground level ozone formation is not only influenced by the strong solar radiation and changing aerosol makeup, but also by other heterogeneous factors and reactions. In addition, this research provided good evidence that the ground level ozone precursor regime in El Paso during the ozone episode of June 2006 was mostly VOC-limited. Much of this estimation was derived from measurements of local ambient VOC/NOx ratios. This finding shows that at least during June 2006, the non-linear surface ozone production increased during weekends compared to workdays in a habitually VOC-limited regime. The seasonal variations of columnar ozone as measured by a Multi-filter Rotating Shadowband instrument installed at the UTEP campus are analyzed for the first time for this region and results are presented. This investigation has addressed the problem of ground-level ozone formation in the Paso del Norte region. Urban ozone is a complex problem with many aspects that are not fully understood. In this investigation, a range of techniques has been used to address the study of local surface ozone episodes with the purpose of acquiring new insights and knowledge that will help understand and remediate the diverse atmospheric pollution events that affect this bi-national region recurrently. Innovative techniques were developed and used, ranging from the use of local ambient atmospheric pollution data to the utilization of complex modeling techniques to achieve the best possible computer results. Finally, the influence of ground level ozone concentrations in admissions to hospitals for this region due to respiratory diseases is analyzed. The comprehensive results obtained in this work will help to better understand ozone formation in the Paso del Norte Region for future policy regulation implementations.

77 FR 77007 - Transfer of Land to the Department of Interior

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... Secretary of the Interior, to be held in trust for the Yurok Tribe. The lands are described as follows: Six...., approved June 24, 1971, and (1) excepting from lands in Sec. 10, a piece or parcel of land conveyed to the..., on pages 92 to 95 of Book 54 of Deeds, Records of Del Norte County, California, said piece or parcel...

Biology of the Rio Grande border region : a bibliography

USGS Publications Warehouse

Johnson, Lynne E.; Jacobs, Linda J.; Papoulias, Diana

1997-01-01

This bibliography includes 1,913 references to the literature of the Rio Grande (Rio Bravo del Norte). The specific geographic area covered extends 100 km on either side of the river from Elephant Butte Dam in New Mexico to the Gulf of Mexico. The bibliography focuses on the biological literature, divided into major subject areas, and also includes supporting literature from the physical and environmental sciences.

Nutrition Knowledge Predicts Eating Behavior of All Food Groups "except" Fruits and Vegetables among Adults in the Paso del Norte Region: Que Sabrosa Vida

ERIC Educational Resources Information Center

Sharma, Shreela V.; Gernand, Alison D.; Day, R. Sue

2008-01-01

Objective: To examine the association between nutrition knowledge and eating behavior in a predominantly Mexican American population on the Texas-Mexico border. Design: Cross-sectional using data from the baseline survey of the Que Sabrosa Vida community nutrition initiative. Setting: El Paso and surrounding counties in Texas. Participants: Data…

Southeast Asia Report

DTIC Science & Technology

1987-03-25

Karya, directorate general, in the introduction of processing a system to keep water free of bacterias by benefiting the power of the sunshine. A...Kalinga-Apayao, Quirino, Quezon, Nueva Ecija, Albay, Mindoro Oriental, Aklan, Lanao del Norte and Davao. The biggest clash was in Mandog, Davao...Isabela. One insurgent was killed in a clash with NPA rebels in Kabugao, Kalinga-Apayao; and other casualties were in Quirino; Nueva Ecija; Sariyaya

Examining the Impact of Academic Development in the Engineering Faculties in Chile: Changes in Teaching Philosophy and Teachers' Competencies

ERIC Educational Resources Information Center

Acosta Peña, Roxana; Tomás-Folch, Marina; Feixas, Mònica

2017-01-01

The Faculties of Engineering Sciences at Universidad Católica del Norte in Chile regard teacher training as a necessary tool for its academics' professional development and as a fundamental way to improve their teaching quality. The Teaching Unit for Innovation in Engineering (UIDIN) has developed a new curriculum and training programme which…

Descripción y distribución de Hydnotrya cerebriformis (Discinaceae: Pezizales) en México. Description of Hydnotrya cerebriformis (Discinaceae: Pezizales) from Mexico

Treesearch

Carolina Piña-Páez; Roberto Garibay-Orijel; Gonzalo Guevara-Guerrero; Michael A. Castellano

2017-01-01

El género Hydnotrya comprende alrededor de 13 especies de Ascomicetos hipogeos, secuestrados ectomicorrízicos distribuidos exclusivamenteen bosques templados del hemisferio norte. En este trabajo se describe e ilustra por primera vez una especie de este género, Hydnotrya cerebriformis,para México. Esta especie se distribuye en...

Use by bats of old-growth redwood hollows on the north coast of California

Treesearch

Steven T. Gellman; William J. Zielinski

1996-01-01

Use by bats of basal hollows in old-growth redwoods was indexed using the weight of guano collected on water-permeable screens (guano traps) installed inside the trees. Twenty-six trees were systematically selected from a stand that flanks both sides of an interstate highway in Del Norte Co., California. Traps were checked for guano once a month for 18 months. The...

Grasslands of Mexico: A perspective on their conservation (Los pastizales del norte de Mexico: Una perspectiva para su conservacion)

Treesearch

Patricia Manzano; Rurik List

2006-01-01

Grasslands are areas dominated by grasses and herbs with few or no trees. Grasslands receive too much rain for a desert environment and too little for a forest. Temperate North American grasslands, especially, have undergone changes on a continental level. Their high productivity and fertility, added to their level topography and lack of trees, make them ideal sites...

55. E.M.C., photographer July 3, 1936 HUMBOLDT COUNTY, SECTION J, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

55. E.M.C., photographer July 3, 1936 HUMBOLDT COUNTY, SECTION J, HIGHWAY 1. 1-HUM-I-J #80, BITUMULS PORTION OF EXPERIMENTAL SECTION, E.M.C, 7-3-36. BACK READS: C/PROCESSING STABILIZING BITUMULS WITH BLADE AFTER BEING PROCESSED WITH SPRING TOOTH HARROW. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

Registros del Cuco Hormiguero (Neomorphus geoffroyi) en la Reserva de Biosfera de Bosawas, Nicaragua

Treesearch

H.M. Herrera-Rosales; M. Tórrez; W.J. Arendt

2014-01-01

El cuco hormiguero, Neomorphus geoffroyi, se registró en la Reserva de Biósfera de Bosawás y representa el primer gráfico de la especie para el Norte y para el país. Esta especie es rara y es sensible a la deforestación, se observó en compañía de bandadas mixtas, con su comportamiento...

Terrestrial and stream amphibians across clearcut-forest interfaces in the Siskiyou Mountains, Oregon

USGS Publications Warehouse

Biek, Roman; Mills, L. Scott; Bury, R. Bruce

2002-01-01

Timber harvest in the Pacific Northwest has resulted in a highly fragmented landscape. but there is no information on responses of amphibians to forest edges for this region. We investigated abundance of terrestrial and stream-dwelling amphibians on the interface of recent clearcuts and mature forest in the Siskiyou Mountains, Oregon, in summer and fall of 1998. We assessed relative abundance of terrestrial -amphibians on four clearcut forest transects with a combination of pitfall trapping and manual searches. Ensantinas and Del Norte salamanders, the most frequently recorded species, were found on all four sites.  While we commonly captured ensantinas using both techniques, we caught most Del Norte salamanders during manual searches. For both species we found no differences in abundance associated with distance to forest edge. Lack of differences in salamander abundance among clearcut and adjacent forests may be related lo large amounts of small woody debris that remained in the clearcuts. The abundance of larvae of tailed frogs and Pacific giant salamanders in five headwater streams was markedly lower in clearcuts than in downstream mature forest stands. No obvious differences existed for stream habitat variables across transects. but abundance of metamorphosed individuals and recruitment may be reduced in clearcut areas due lo hotter and drier conditions during

Fotometría de grupos compactos de galaxias: Shakhbazian 37, 45, 166, 331 y 362

NASA Astrophysics Data System (ADS)

Campos, J. M.; Calderón, J. H.; Gimeno, N. G.; Díaz, R. J.

Continuando con la fotometría CCD de Grupos de Galaxias Compactos de Shakhbazyan (SCGG) en este trabajo se presentan nuevos resultados preliminares sobre los grupos Shakbazyan 37, 45, 166, 331 y 362. EL objeto del proyecto es contribuir al estudio de las propiedades físicas de tales grupos y contribuir a las bases de datos para mejora de las estadísticas. Los datos fueron adquiridos con el Telescopio JKT del Observatorio Norte Europeo. El análisis de las imágenes en las bandas I y B como del índice de color B-I permitió reidentificar las galaxias catalogadas, resultando las mismas muy enrojecidas y verificando que predominan las galaxias tempranas, resultados consistentes con los obtenidos para otros grupos y por otros autores.

Relevamiento total del hemisferio sur celeste en la frecuencia de 1420 MHz

NASA Astrophysics Data System (ADS)

Bava, J. A.; Colomb, F. R.; Hurrel, E.; Larrarte, J. J.; Sanz, A. J.; Testori, J. C.; Reich, P.; Reich, W.; Wielebinski, R.

En el presente artículo se describe el relevamiento del cielo en el Hemisferio Sur Celeste en la frecuencia de 1420 MHz para declinaciones δ<= -19o realizado con la Antena II de 30 metros de diámetro del IAR. Este relevamiento posee igual sensibilidad (3xr.m.s=50 mK) que el realizado en el Hemisferio Norte con el radiotelescopio de 25 metros de Stockert de la Universidad de Bonn, operado por el Max-Planck Institute für Radioastronomie ( Reich W., 1982, A&ASS 48, 219; Reich P. and Reich W., 1986, A&ASS 63, 205). Con los datos obtenidos por ambos radiotelescopios se posee una base de datos de todo el cielo en esta frecuencia. En esta publicación presentamos los detalles del sistema receptor, técnicas de observación y reducción de datos, calibración y discusión de los errores en los resultados.

Relevamiento de HI en el Hemisferio Austral

NASA Astrophysics Data System (ADS)

Arnal, E. M.; Bajaja, E.; Morras, R.; Pöppel, W. G. L.

Un nuevo relevamiento de HI de todo el Hemisferio Austral, comprendido entre -90o <= δ <= -25o, está siendo observado con la antena I del IAR. El mismo es realizado con alta sensibilidad (r.m.s.<= 0.07 K) y alta resolución espectral (1 Km/s). Un total de ~50000 posiciones en el cielo serán observadas, espaciadas en una grilla (lxb) de (0.5o x 0.5o). El intervalo de velocidades cubierto en este relevamiento abarca el rango -450 km/s a +450 km/s en el sistema LSR. Esta base de datos será corregida por efectos de ``stray radiation''. Al presente se ha observado ~70% del total del relevamiento. El mismo es complementario de uno similar realizado en el Hemisferio Norte por Hartman y Burton (1996), con cubrimiento espacial, sensibilidad, resoluciones espaciales y en velocidad, similares a los del IAR. El objetivo final de ambos relevamientos es disponer de una base de datos uniforme en todo el cielo.

Guidebook to the Gaudalupian symposium

USGS Publications Warehouse

Rohr, D.M.; Wardlaw, B.R.; Rudine, S.F.; Haneef, Mohammad; Hall, A.J.; Grant, R.E.

2000-01-01

Compared to the Guadalupe Mountains of Texas and New Mexico the depositional environments of the Permian strata of the Glass Mountains (and adjacent Del Norte Mountains) are less well known. In general, the Guadalupian facies in the the Glass and Del Norte mountains changes from predominantly carbonate facies in the northeast to thicker clastic facies in the southwest. Philip B. Kind (1931) originally considered this trend to reflect an uplifted clastic source to the southwest, with carbonate facies developing away from the source area. Ross (1986) interpreted the eastern portion of the Road Canyon and Word formations to consist the shelf, shelf-edge bioherm, and reef facies, and the southwest area to consist of deeper water siliceous shale, clastic limestone, and basinal sandstone facies. Probably the best known controversy in the Glass Mountains involves the depositional environment of the Skinner Ranch Formation (Leonardian according to Ross, 1986; Wolfcampian according to Cooper and Grant, 1972) at its type section on Leonard Mountain. Cooper and Grant (1964) identified in situ patch reefs at the base of the section, which were subsequently interpreted as displaced limestone blocks deposited in a slope environment (Rogers, 1972; Cys and Mazzullo, 1978; Ross, 1986). Later Flores, McMillan, and Watters (1977) interpreted the same units as subtidal and intertidal deposits. The Skinner Ranch Formation illustrates the complexities involved in interpreting the paleogeography of the Glass Mountains. If the Sinner Ranch contains displaced blocks, some eroded from older units, it explains the occurrence of Wolfcampian fossils in the Skinner Ranch (Ross, 1986).The slop facies interpretation also is used to place the shelf edge at that time between Skinner Ranch outcrops at Leonard Mountain and the lagoonal, backreef deposits of the Hess Formation to the east, although most of the actual shelf edge is not preserved (Ross, 1987:30). Similar conflicting interpretations exist in younger rocks in the western facies of the Leonardian Guadalupian to the southwest in the Del Norte Mountains. Ross (1986, 1987) considered the western facies of the Road Canyon and Word formations to be basinal shales and turbidites. Wardlaw et al. (1990) and Rohr et al. (1987) have interpreted this area to be shallow intertidal to lagoonal environments adjacent to an uplifted area to the south. The type section of the Road Canyon Formation is also a subject of disagreement and will be discusses in more detail later.

78 FR 8745 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Tidewater Goby

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-06

...We, the U.S. Fish and Wildlife Service, designate critical habitat for the tidewater goby (Eucyclogobius newberryi) under the Endangered Species Act of 1973, as amended (Act). In total, approximately 12,156 acres (4,920 hectares) in Del Norte, Humboldt, Mendocino, Sonoma, Marin, San Mateo, Santa Cruz, Monterey, San Luis Obispo, Santa Barbara, Ventura, Los Angeles, Orange, and San Diego Counties, California, fall within the boundaries of the critical habitat designation.

Copper uptake by Pteris melanocaulon Fée from a Copper-Gold mine in Surigao del Norte, Philippines.

PubMed

De la Torre, Joseph Benjamin B; Claveria, Rene Juna R; Perez, Rubee Ellaine C; Perez, Teresita R; Doronila, Augustine I

2016-01-01

The ability of some plants to take up metal contaminants in the soil has been of increasing interest as an environmental approach to pollution clean-up. This study aimed to assess the ability of Pteris melanocaulon for copper(Cu) uptake by determining the Cu levels in the fern vis-à-vis surrounding soil and the location of Cu accumulation within its biomass. It also aimed to add information to existing literature as P. melanocaulon are found to be less documented compared to other fern metal accumulators, such as P. vittata. The P. melanocaulon found in the Suyoc Pit of a Copper-Gold mine in Placer, Surigao del Norte, Philippines exhibited a high Bioaccumulation Factor(BF) of 4.04 and a low Translocation Factor(TF) of 0.01, suggesting more Cu accumulation in the roots (4590.22 ± 385.66 µg g(-1) Cu). Noteworthy was the Cu concentration in the rhizome which was also high (3539.44 ± 1696.35 µg g(-1) Cu). SEM/EDX analyses of the Cu content in the roots indicated high elemental %Cu in the xylem (6.95%) than in the cortex (2.68%). The high Cu content in the roots and rhizomes and the localization of Cu in the xylem manifested a potential utilization of the fern as a metallophyte for rhizofiltration and phytostabilization.

Mapa Geologico de Venezuela a Escala 1:750,000

USGS Publications Warehouse

Hackley, Paul C.; Urbani, Franco; Karlsen, Alex W.; Garrity, Christopher P.

2006-01-01

Se presenta un mapa geologico digital de Venezuela sobre un fondo de relieve sombreado. Los datos geologicos e hidrologicos del norte del rio Orinoco proceden de la digitalizacion de mapas geologicos en papel a escala 1:500.000. Estos datos fueron integrados con el mapa geologico digital del Escudo de Guayana Venezolano, a su vez derivado de hojas en papel a escala 1:500.000. La informacion sobre los tipos de fallas mostrados en el mapa es igual que en las fuentes originales. Los poligonos geologicos fueron atribuidos por edad, litologia y nombre de la unidad siguiendo el Codigo geologico de Venezuela. Se incorporaron revisiones significativas de la geologia de la Cordillera de la Costa a partir de las nuevas hojas integradas a escala 1:25.000. Toda esta informacion geologico-estructural se sobrepuso a una imagen de relieve sombreado, producida por el procesamiento de los datos de radar interferometrico con 90 m (3 arcosegundos) de resolucion espacial obtenidos por la mision topografica de radar del transbordador espacial (SRTM). Las areas de la base de datos del SRTM carentes de informacion fueron llenadas por medio de la interpolacion de los datos de las celdas adyacentes. Para producir la imagen de relieve sombreado se uso una direccion de iluminacion de 315 deg con un angulo de 65 deg sobre el horizonte. La proyeccion usada en el mapa es conica equidistante, con latitudes de 4 y 9 deg norte como paralelos estandar y una longitud de 66 deg al oeste como meridiano central. Los datos en el mapa proceden primordialment de hojas a escala 1:500.000 y el producto esta preparado para una impresion optima en escala 1:750.000. Los usuarios pueden obtener ampliaciones mayores, sin embargo no se garantiza la precision del mapa a escalas mas detalladas. Especialmente en la region de Guayana, al sobreponer los mapas geologicos sobre la reciente imagen SRTM, se notan grandes discrepancias no sistematicas tanto en contactos como en fallas. Esto es debido a que los mapas geologicos de Guayana tienen como base topografica las imagenes de radar de vision lateral (SLAR), con muy control de campo de los a?os 1970's. La correccion de estos desfases esta planificada para el futuro.

Army Installations Water Sustainability Assessment: An Evaluation of Vulnerability to Water Supply

DTIC Science & Technology

2009-09-01

del Norte Water Task Force PM particulate matter PNNL Pacific Northwest National Laboratory PWC Public Works Commission PWD RFTA RSC Regional...ct io n E n gi n ee ri n g R es ea rc h L ab or at or y Approved for public release; distribution is unlimited. ERDC/CERL TR-09-38...and Ryan Holmes University of Illinois at Urbana-Champaign Final Report Approved for public release; distribution is unlimited. Prepared for U.S

Produccion de plantas grandes usando minicontenedores

Treesearch

R. Kasten Dumroese; Thomas D. Landis

2012-01-01

En América del Norte hay cada vez más interés por la producción híbrida o mixta. La misma consiste en cultivar plantines en contenedores de pequeño volumen y luego trasplantarlos; el trasplante se puede realizar a canteros en el suelo como en la producción a raíz desnuda o bien a contenedores más grandes. Originalmente se llamaban plantines "plug+", "...

Meteorological Simulations of Ozone Episode Case Days during the 1996 Paso del Norte Ozone Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, M.J.; Costigan, K.; Muller, C.

1999-02-01

Meteorological simulations centered around the border cities of El Paso and Ciudad Juarez have been performed during an ozone episode that occurred on Aug. 13,1996 during the 1996 Paso del Norte Ozone Study field campaign. Simulations were petiormed using the HOTMAC mesoscale meteorological model using a 1,2,4, and 8 km horizontal grid size nested mesh system. Investigation of the vertical structure and evolution of the atmospheric boundary layer for the Aug. 11-13 time period is emphasized in this paper. Comparison of model-produced wind speed profiles to rawirisonde and radar profiler measurements shows reasonable agreement. A persistent upper-level jet was capturedmore » in the model simulations through data assimilation. In the evening hours, the model was not able to produce the strong wind direction shear seen in the radar wind profiles. Based on virtual potential temperature profile comparisons, the model appears to correctly simulate the daytime growth of the convective mixed layer. However, the model underestimates the cooling of the surface layer at night. We found that the upper-level jet significantly impacted the turbulence structure of the boundary layer, leading to relatively high turbulent kinetic energy (tke) values aloft at night. The model indicates that these high tke values aloft enhance the mid-morning growth of the boundary layer. No upper-level turbulence measurements were available to verify this finding, however. Radar profiler-derived mixing heights do indicate relatively rapid morning growth of the mixed layer.« less

TGS pipeline primed for Argentine growth, CEO says

DOE Office of Scientific and Technical Information (OSTI.GOV)

Share, J.

Nowhere in Latin America has the privatization process been more aggressively pursued than in Argentina where President Carlos Menem has successfully turned over the bulk of state companies to the private sector. In the energy sector, that meant the divestiture in 1992 of Gas del Estado, the state-owned integrated gas transportation and distribution company. It was split in two transportation companies: Transportadora de Gas del Sur (TGS) and Transportadora de Gas del Norte (TGN), and eight distribution companies. TGS is the largest transporter of natural gas in Argentina, delivering more than 60 percent of that nation`s total gas consumption withmore » a capacity of 1.9 Bcf/d. This is the second in a series of Pipeline and Gas Journal special reports that discuss the evolving strategies of the natural gas industry as it continues to restructure amid deregulation. The article focuses on TGS, the Argentine pipeline system in which Enron Corp. is a key participant.« less

76 FR 64995 - Endangered and Threatened Wildlife and Plants; Designation of Revised Critical Habitat for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-19

...We, the U.S. Fish and Wildlife Service (Service), propose to revise critical habitat for the tidewater goby (Eucyclogobius newberryi) under the Endangered Species Act of 1973, as amended (Act). In total, approximately 12,157 acres (4,920 hectares) are being proposed for designation as critical habitat. The proposed revised critical habitat is located in Del Norte, Humboldt, Mendocino, Sonoma, Marin, San Mateo, Santa Cruz, Monterey, San Luis Obispo, Santa Barbara, Ventura, Los Angeles, Orange, and San Diego Counties, California.

Late Leonardian plants from West Texas: The youngest Paleozoic plant megafossils in North America

USGS Publications Warehouse

Mamay, S.H.; Miller, J.M.; Rohr, D.M.

1984-01-01

Abundant Permian plant megafossils were discovered in the Del Norte Mountains of Brewster County, Trans-Pecos Texas. The flora is dominated by a new and distinctive type of gigantopteroid leaves. Marine invertebrates are closely associated, and this admixture of continental and marine fossils indicates a deltaic depositional setting, probably on the southern margin of the Permian Basin. Conodonts indicate correlation with the uppermost Leonardian Road Canyon Formation in the Glass Mountains. These are the youngest Paleozoic plant megafossils known in North America; they add an important paleontological element to the classic Permian area of this Continent.

Mapping of High Value Crops Through AN Object-Based Svm Model Using LIDAR Data and Orthophoto in Agusan del Norte Philippines

NASA Astrophysics Data System (ADS)

Candare, Rudolph Joshua; Japitana, Michelle; Cubillas, James Earl; Ramirez, Cherry Bryan

2016-06-01

This research describes the methods involved in the mapping of different high value crops in Agusan del Norte Philippines using LiDAR. This project is part of the Phil-LiDAR 2 Program which aims to conduct a nationwide resource assessment using LiDAR. Because of the high resolution data involved, the methodology described here utilizes object-based image analysis and the use of optimal features from LiDAR data and Orthophoto. Object-based classification was primarily done by developing rule-sets in eCognition. Several features from the LiDAR data and Orthophotos were used in the development of rule-sets for classification. Generally, classes of objects can't be separated by simple thresholds from different features making it difficult to develop a rule-set. To resolve this problem, the image-objects were subjected to Support Vector Machine learning. SVMs have gained popularity because of their ability to generalize well given a limited number of training samples. However, SVMs also suffer from parameter assignment issues that can significantly affect the classification results. More specifically, the regularization parameter C in linear SVM has to be optimized through cross validation to increase the overall accuracy. After performing the segmentation in eCognition, the optimization procedure as well as the extraction of the equations of the hyper-planes was done in Matlab. The learned hyper-planes separating one class from another in the multi-dimensional feature-space can be thought of as super-features which were then used in developing the classifier rule set in eCognition. In this study, we report an overall classification accuracy of greater than 90% in different areas.

Classification of Nortes in the Gulf of Mexico derived from wave energy maps

NASA Astrophysics Data System (ADS)

Appendini, C. M.; Hernández-Lasheras, J.

2016-02-01

Extreme wave climate in the Gulf of Mexico is determined by tropical cyclones and winds from the Central American Cold Surges, locally referred to as Nortes. While hurricanes can have catastrophic effects, extreme waves and storm surge from Nortes occur several times a year, and thus have greater impacts on human activities along the Mexican coast of the Gulf of Mexico. Despite the constant impacts from Nortes, there is no available classification that relates their characteristics (e.g. pressure gradients, wind speed), to the associated coastal impacts. This work presents a first approximation to characterize and classify Nortes, which is based on the assumption that the derived wave energy synthetizes information (i.e. wind intensity, direction and duration) of individual Norte events as they pass through the Gulf of Mexico. First, we developed an index to identify Nortes based on surface pressure differences of two locations. To validate the methodology we compared the events identified with other studies and available Nortes logs. Afterwards, we detected Nortes from the 1986/1987, 2008/2009 and 2009/2010 seasons and used their corresponding wind fields to derive the wave energy maps using a numerical wave model. We used the energy maps to classify the events into groups using manual (visual) and automatic classifications (principal component analysis and k-means). The manual classification identified 3 types of Nortes and the automatic classification identified 5, although 3 of them had a high degree of similarity. The principal component analysis indicated that all events have similar characteristics, as few components are necessary to explain almost all of the variance. The classification from the k-means indicated that 81% of analyzed Nortes affect the southeastern Gulf of Mexico, while a smaller percentage affects the northern Gulf of Mexico and even less affect the western Caribbean.

El Proyecto Gémini: informe actualizado y técnica de observación

NASA Astrophysics Data System (ADS)

Sahade, J.; Lapasset, E.; Levato, H.

Se describirá la situación actual en lo que se refiere al desarrollo del Proyecto Gémini en cuanto a su estructura, faz constructiva y programación general. Se informará sobre los planes a desarrollar en el tiempo de verificación científica y puesta a punto del instrumental, a partir de la primera imagen que se obtenga con el telescopio Gemini Norte. Se presentará, además, el plan operativo para observar con los telescopios Gemini tal cual está concebido hasta la fecha, describiéndose el proceso desde el mismo momento en que un investigador decide presentar una propuesta para observar con uno de los telescopios, hasta el archivo y derechos de propiedad sobre los datos. Se decribe también el ``soft" denominado Observing Tool (OT) que es clave en la planificación científica de Gemini y que puede ser utilizado ``off-line" en cualquier PC con un entorno windows.

"El Norte," Deracination and Circularity: An Epic Gone Awry

ERIC Educational Resources Information Center

Brakel, Arthur

2007-01-01

Early journalistic reviews (e.g., Gold, Ebert, and Kael) of "El Norte" (1983), Gregory Nava's first major film, identify it as an epic. In "El Norte" the siblings Enrique and Rosa, two Guatemalan Amerindians, leave their native village on a quest to what for them is the mythical land in the North. Although "El Norte"…

Estimation of Depth and Attenuation of Earthquakes in Bolivia

DTIC Science & Technology

2000-09-01

motion. Bull . Seism. Soc. Am. 65, 139-162. Vega, A.J., 1994. El gran terremoto profundo del día 9 de junio de 1994 en el norte de la República de...Trinid a d C uzc o A re q uip a La Pa z C o c ha b a m b a Sa nta C ruz O ruro Po to sí Suc re Ta rija A ric a A nto fa g a sta Sa lta C H ILE A RG EN ...central station, Colegio Juan XXIII. In order to determine the depths of earthquakes in the region of Bolivia more reliably, a study has been made of

Profile and birthing practices of Maranao traditional birth attendants.

PubMed

Maghuyop-Butalid, Roselyn; Mayo, Norhanifa A; Polangi, Hania T

2015-01-01

This study determined the profile and birthing practices in both modern and traditional ways among Maranao traditional birth attendants (TBAs) in Lanao del Norte, Philippines. It employed a descriptive research design. The respondents were 50 Maranao TBAs selected through the snowball sampling technique. A questionnaire was developed by the researchers to identify the respondents' modern birthing practices utilizing the Essential Intrapartum and Newborn Care (EINC) Protocol. To determine their profile and traditional birthing practices, items from a previous study and the respondents' personal claims were adapted. This study shows that Maranao TBAs have less compliance to the EINC Protocol and they often practice the traditional birthing interventions, thus increasing the risk of complications to both mother and newborn.

7. OBLIQUE VIEW OF NORTH PORTAL AND DOWNSTREAM SIDE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. OBLIQUE VIEW OF NORTH PORTAL AND DOWNSTREAM SIDE OF BRIDGE, LOOKING WEST. Lights and illuminated sign on portal bracing were elements of an overheight load warning system designed to eliminate accidents of the type which damaged the bridge. However, the system was in place only on the north side of the bridge, controlling trucks approaching from Oregon. In theory, trucks with overheight, overwidth, or overweight loads from California would be controlled by the State's permit system. In fact, it was a 'permit' load originating in California, being hauled without the requisite permit which struck and damaged the bridge. - Smith River Bridge, CA State Highway 199 Spanning Smith River, Crescent City, Del Norte County, CA

Astronomía Gamma desde El Leoncito

NASA Astrophysics Data System (ADS)

Rovero, A. C.; Colombo, E.; Sahade, J.; Weekes, T. C.

La astronomía gamma, en el extremo de energías detectadas hasta el presente, se encuentra en desarrollo en muchas partes del mundo y proporciona resultados sorprendentes a medida que la tecnología avanza en el desarrollo de nuevos detectores. La técnica Cherenkov Atmosférica es la utilizada para la detección, mediante telescopios en tierra, del efecto secundario causado por la radiación gamma de muy altas energías (E ≈ TeV). Por medio de telescopios o arreglos de detectores y utilizando la técnica mencionada, se han podido detectar algunas fuentes puntuales de mucha importancia astrofísica como la Nebulosa del Cangrejo y la galaxia de núcleo activo Markarian 421. El sistema instalado en San Juan, en cooperación con el grupo de Radiación Gamma del Observatorio Whipple, está constituído por tres colectores de 1.5m que registran pulsos de luz generados por las cascadas de partículas producidas por rayos cósmicos de todo tipo al entrar en la atmósfera terrestre. El sistema opera por barrido en ascención recta de la fuente observada que, para esta etapa del experimento, es el Centro Galáctico. Esta fuente extensa es conocida como emisor gamma de energías inferiores al TeV y ha sido observada anteriormente en este rango de energía desde el hemisferio norte pero con elevaciones bajas, situación no óptima para este tipo de técnica. Se presentan los primeros resultados del análisis de los datos obtenidos observando la región del Centro Galáctico, luego de dos años de observaciones, así como una descripción de la técnica Cherenkov Atmosférica y del equipo utilizado en la experiencia.

A Coastal Citizen Science Project - How to run an international Citizen Science Project?

NASA Astrophysics Data System (ADS)

Kruse, K.; Knickmeier, K.; Thiel, M.; Gatta, M.

2016-02-01

"Searching for plastic garbage" is an international Citizen Science project that aims to participate school students in the public discussion on the topic "plastic pollution in the ocean". For this, young people apply various research methods, evaluate their data, communicate and publish their results and investigate solutions solving this problem. The project will be carried out in Chile and Germany at the same time, which allows the participating students to share and compare their results and discuss their ideas with an international partner. This takes place on the website www.save-ocean.org. The project promotes intercultural and scientific skills of the students. They get insights into scientific research, get into another culture and experiences plastic pollution as an important global problem. Since May 2015, 450 pupils aged 10 to 15 years and 20 teachers in Germany and Chile have explored the plastic garbage on beaches. Where are the largest plastic garbage deposits? Which items of plastic are mostly found in Germany and Chile? Or where does this garbage comes from? These and other research questions are being answered by an international network between students, teachers and scientists. After completing the first Citizen Science pilot study successfully in summer 2015, the entire German and Chilean coast will be explored in spring 2016 by around 2500 participating school students. The project "Searching for plastic garbage" is the first international Citizen Science project that is a cooperation between the ocean:lab of Kiel Science Factory and the "Cientificos de la Basura", a project of the department of marine biology at University Catolica del Norte in Coquimbo, Chile. The project is supported by the Cluster of Excellence "The Future Ocean", the Leibniz Institute for Science Education and Mathematics (IPN), the Ministry of School and Professional Education of Land Schleswig-Holstein and the University Catolica del Norte in Coquimbo, Chile

Hydrocarbon source apportionment for the 1996 Paso del Norte Ozone Study.

PubMed

Fujita, E M

2001-08-10

The 1996 Paso del Norte (PdN) ozone study was conducted to improve current understanding of the significant meteorological and air quality processes that lead to high concentrations of ozone in El Paso, Texas (USA) and Ciudad Juárez, Chihuahua (Mexico). Two-hour canister samples were collected five times daily at 05.00-07.00 h, 07.00-09.00 h, 09.00-11.00 h, 11.00-13.00 h, and 15.00-17.00 h MST during intensive study periods at one urban and one rural site on each side of the border. An automated gas chromatograph was operated at one site in central El Paso. Source profiles (the fractional chemical composition of emissions) from motor vehicles, gasoline, liquefied petroleum gas, and commercial natural gas were combined with source profiles from other studies for input to the Chemical Mass Balance (CMB) receptor model to apportion the measured non-methane hydrocarbons (NMHC) to sources. On-road vehicle emissions accounted for one-half to two-thirds of the NMHC in Ciudad Juárez and El Paso with the highest contributions occurring during the morning and afternoon commute periods. Emissions from diesel exhaust contributed approximately 2-3% of NMHC in Ciudad Juárez and less than 2% in El Paso. The average sum of liquid gasoline and gasoline vapor increased during the day in Ciudad Juárez from 2% at 06.00 h to approximately 12% at 16.00 h. Diurnal and day-of-the-week patterns in the liquid gasoline contributions are essentially identical to the corresponding patterns for motor vehicle exhaust, which suggest that a large fraction of the liquid gasoline contribution may be associated with tailpipe emissions rather than evaporative emissions from motor vehicles or industrial sources. Including the sum of the two sources put the upper limit for tailpipe contributions at 60-70% of NMHC.

VizieR Online Data Catalog: BVIc light curves of 57 Cepheids (Berdnikov+,

NASA Astrophysics Data System (ADS)

Berdnikov, L. N.; Kniazev, A. Yu.; Sefako, R.; Kravtsov, V. V.; Zhujko, S. V.

2014-04-01

In 2008-2013, we obtained 11333 CCD BV Ic frames for 57 Cepheids from the General Catalogue of Variable Stars. We performed our observations with the 76-cm telescope of the South AfricanAstronomicalObservatory (SAAO, South Africa) and the 40-cm telescope of the Cerro Armazones Astronomical Observatory of the Universidad Catolica del Norte (OCA, Chile) using the SBIG ST-10XME CCD camera. The tables of observations, the plots of light curves, and the current light elements are presented. Comparison of our light curves with those constructed from photoelectric observations shows that the differences between their mean magnitudes exceed 0.05mag in 20% of the cases. This suggests the necessity of performing CCD observations for all Cepheids. (2 data files).

CCD BVI c observations of Cepheids

NASA Astrophysics Data System (ADS)

Berdnikov, L. N.; Kniazev, A. Yu.; Sefako, R.; Kravtsov, V. V.; Zhujko, S. V.

2014-02-01

In 2008-2013, we obtained 11333 CCD BVI c frames for 57 Cepheids from the General Catalogue of Variable Stars. We performed our observations with the 76-cm telescope of the South African Astronomical Observatory (SAAO, South Africa) and the 40-cm telescope of the Cerro Armazones Astronomical Observatory of the Universidad Católica del Norte (OCA, Chile) using the SBIG ST-10XME CCD camera. The tables of observations, the plots of light curves, and the current light elements are presented. Comparison of our light curves with those constructed from photoelectric observations shows that the differences between their mean magnitudes exceed 0ṃ05 in 20% of the cases. This suggests the necessity of performing CCD observations for all Cepheids.

Border Environmental Education Resource Guide: Southern New Mexico, South Texas, Northern Chihuahua, Northern Coahuila, Northern Nuevo Leon, Northern Tamaulipas = Guia de Recursos de Educacion Ambiental en la Frontera: Sur de Nuevo Mexico, Sur de Texas, Norte de Chihuahua, Norte de Coahuila, Norte de Nuevo Leon, Norte de Tamaulipas.

ERIC Educational Resources Information Center

Meissner, David, Comp.

This guide provides educators and residents of the border with useful information about environmental education program offerings along the eastern half of the United States-Mexico border. The programs listed in the guide represent a broad range of educational efforts focused on understanding the environment and solving environmental problems in…

Effect of climate change on wind waves generated by anticyclonic cold front intrusions in the Gulf of Mexico

NASA Astrophysics Data System (ADS)

Appendini, Christian M.; Hernández-Lasheras, Jaime; Meza-Padilla, Rafael; Kurczyn, Jorge A.

2018-01-01

Anticyclonic cold surges entering the Gulf of Mexico (Nortes) generate ocean waves that disrupt maritime activities. Norte derived waves are less energetic than the devastating waves from tropical cyclones, but more frequent ( 22 events/year) and with larger spatial influence. Despite their importance, few studies characterize Nortes derived waves and assess the effects of climate change on their occurrence. This study presents a method to identify and characterize Nortes with relation to their derived waves in the Gulf of Mexico. We based the identification of Nortes on synoptic measurements of pressure differences between Yucatan and Texas and wind speed at different buoy locations in the Gulf of Mexico. Subsequently, we identified the events in the CFSR reanalysis (present climate) and the CNRM-M5 model for the present climate and the RCP 8.5 scenario. We then forced a wave model to characterize the wave power generated by each event, followed by a principal component analysis and classification by k-means clustering analysis. Five different Nortes types were identified, each one representing a characteristic intensity and area of influence of the Norte driven waves. Finally, we estimated the occurrence of each Norte type for the present and future climates, where the CNRM-M5 results indicate that the high-intensity events will be less frequent in a warming climate, while mild events will become more frequent. The consequences of such changes may provide relief for maritime and coastal operations because of reduced downtimes. This result is particularly relevant for the operational design of coastal and marine facilities.

Puerto Rico, humedales [Puerto Rico, wetlands

USGS Publications Warehouse

Adams, D. Briane; Hefner, John M.; Dopazo, Teresa

1999-01-01

La isla de Puerto Rico, localizada al noreste del Mar Caribe y sus islas principales, Vieques, Culebra e Isla de Mona, poseen humedales en abundancia . El clima subtropical, la lluvia abundante y las complejas formas topográficas y geológicas de estas islas dan origen a los humedales, que varían desde los raros e inusuales bosques cubiertos por nubes en las tierras altas, hasta los extensos manglares, yerbas marinas y arrecifes de coral a lo largo de las costas Norte y Sur. Sin embargo, los humedales en Puerto Rico han disminuido en los últimos siglos como resultado del aumento en el desarrollo agrícola, poblacional y turístico. Algunos tipos de humedales como los bosques de palo de pollo (Pterocarpus officinalis) se han reducido a sólo unos pocos remanentes (figura 1).Biológicamente hablando, los humedales de las islas están entre las áreas más productivas. Los humedales asociados con el bosque pluvial en las tierras altas del interior de Puerto Rico contienen varias plantas raras y especies de animales que no se encuentran en otras partes de la Isla. El agua de escorrentía proveniente de los humedales en las partes altas de la Isla proveen una fuente de agua que utilizan varias ciudades para abasto público. Los humedales costeros como los mangles, los colchones de yerbas marinas y los arrecifes de coral proveen áreas para la reproducción y crianza de varios peces, crustáceos y otras especies en la cadena alimenticia (López y otros, 1988). De esta manera, los humedales costeros contribuyen a la productividad biológica de las aguas llanas del mar alrededor de las islas . Los humedales también estabilizan las costas atrapando y reteniendo sedimentos no consolidados y amortiguan la acción de las olas y de las tormentas que tienen el potencial de causar daños en la zona.El valor de los humedales de Puerto Rico para la vida silvestre está muy bien documentado . Por ejemplo, las salinas de Cabo Rojo, en la costa suroeste, proveen áreas para el descanso y la alimentación de cientos de aves migratorias en ruta entre Norte y Suramérica. Antes del drenaje de los humedales costeros para propósitos agrícolas, pantanos de agua dulce como los de la Laguna Cartagena, Laguna Guánica y Ciénaga El Anegado proveían hábitat a más de 1 00 especies de aves residentes y migratorias . Los humedales de las tierras altas del área central son el último refugio de la cotorra puertorriqueña, una especie en peligro de extinción. Aún los humedales del área metropolitana de San Juan (Laguna La Torrecilla, Torrecilla Baja, Laguna de Piñones hasta Punta Vacía Talega) proveen un hábitat excelente para la vida silvestre, mantienen criaderos de peces de alto valor económico y proveen recreación y oportunidades educativas a la población urbana.Treintiocho especies de vertebrados, moluscos y crustáceos, y 46 especies de aves, algunos raros o en peligro de extinción como la mariquita, el alcatraz, el pato dominicano, el pato silbón y la paloma cabeciblanca han sido observados en el área . También las playas asociadas con estos humedales urbanos proveen sitios de anidaje para las tortugas carey de concha y tinglar, ambas en peligro de extinción (Del Llano y otros, 1986).

Streamflow gains and losses and selected water-quality observations in five subreaches of the Rio Grande/Rio Bravo del Norte from near Presidio to Langtry, Texas, Big Bend area, United States and Mexico, 2006

USGS Publications Warehouse

Raines, Timothy H.; Turco, Michael J.; Connor, Patrick J.; Bennett, Jeffery B.

2012-01-01

Few historical streamflow and water-quality data are available to characterize the segment of the Rio Grande/Rio Bravo del Norte (hereinafter Rio Grande) extending from near Presidio to near Langtry, Texas. The U.S. Geological Survey, in cooperation with the National Park Service and the Texas Commission on Environmental Quality, collected water-quality and streamflow data from the Rio Grande from near Presidio to near Langtry, Texas, to characterize the streamflow gain and loss and selected constituent concentrations in a 336.3-mile reach of the Rio Grande from near Presidio to near Langtry, Texas. Streamflow was measured at 38 sites and water-quality samples were collected at 20 sites along the Rio Grande in February, March, and June 2006. Streamflow gains and losses over the course of the stream were measured indirectly by computing the differences in measured streamflow between sites along the stream. Water-quality data were collected and analyzed for salinity, dissolved solids, major ions, nutrients, trace elements, and stable isotopes. Selected properties and constituents were compared to available Texas Commission on Environmental Quality general use protection criteria or screening levels. Summary statistics of selected water-quality data were computed for each of the five designated subreaches. Streamflow gain and loss and water-quality constituent concentration were compared for each subreach, rather than the entire segment because of the temporal variation in sample collection caused by controlled releases upstream. Subreach A was determined to be a losing reach, and subreaches B, C, D, and E were determined to be gaining reaches. Compared to concentrations measured in upstream subreaches, downstream subreaches exhibited evidence of dilution of selected constituent concentrations. Subreaches A and B had measured total dissolved solids, chloride, and sulfate exceeding the Texas Commission on Environmental Quality general use protection criteria. Subreaches C, D, and E did not exceed the general use protection criteria for any constituent concentration criteria, but dissolved oxygen concentrations did not meet the general use criteria in these subreaches.

Integrating Photovoltaic Systems into Low-Income Housing Developments: A Case Study on the Creation of a New Residential Financing Model and Low-Income Resident Job Training Program, September 2011 (Brochure)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dean, J.; Smith-Dreier, C.; Mekonnen, G.

2011-09-01

This case study covers the process of successfully integrating photovoltaic (PV) systems into a low-income housing development in northeast Denver, Colorado, focusing specifically on a new financing model and job training. The Northeast Denver Housing Center (NDHC), working in cooperation with Del Norte Neighborhood Development Corporation, Groundwork Denver, and the National Renewable Energy Laboratory (NREL), was able to finance the PV system installations by blending private equity funding with utility rebates, federal tax credits, and public sector funding. A grant provided by the Governor's Energy Office allowed for the creation of the new financing model. In addition, the program incorporatedmore » an innovative low-income job training program and an energy conservation incentive program.« less

Geophysics- and geochemistry-based assessment of the geochemical characteristics and groundwater-flow system of the U.S. part of the Mesilla Basin/Conejos-Médanos aquifer system in Doña Ana County, New Mexico, and El Paso County, Texas, 2010–12

USGS Publications Warehouse

Teeple, Andrew P.

2017-06-16

One of the largest rechargeable groundwater systems by total available volume in the Rio Grande/Río Bravo Basin (hereinafter referred to as the “Rio Grande”) region of the United States and Mexico, the Mesilla Basin/Conejos-Médanos aquifer system, supplies water for irrigation as well as for cities of El Paso, Texas; Las Cruces, New Mexico; and Ciudad Juárez, Chihuahua, Mexico. The U.S. Geological Survey in cooperation with the Bureau of Reclamation assessed the groundwater resources in the Mesilla Basin and surrounding areas in Doña Ana County, N. Mex., and El Paso County, Tex., by using a combination of geophysical and geochemical methods. The study area consists of approximately 1,400 square miles in Doña Ana County, N. Mex., and 100 square miles in El Paso County, Tex. The Mesilla Basin composes most of the study area and can be divided into three parts: the Mesilla Valley, the West Mesa, and the East Bench. The Mesilla Valley is the part of the Mesilla Basin that was incised by the Rio Grande between Selden Canyon to the north and by a narrow valley (about 4 miles wide) to the southeast near El Paso, Tex., named the Paso del Norte, which is sometimes referred to in the literature as the “El Paso Narrows.”Previously published geophysical data for the study area were compiled and these data were augmented by collecting additional geophysical and geochemical data. Geophysical resistivity measurements from previously published helicopter frequency domain electromagnetic data, previously published direct-current resistivity soundings, and newly collected (2012) time-domain electromagnetic soundings were used in the study to detect spatial changes in the electrical properties of the subsurface, which reflect changes that occur within the hydrogeology. The geochemistry of the groundwater system was evaluated by analyzing groundwater samples collected in November 2010 for physicochemical properties, major ions, trace elements, nutrients, pesticides (reported but not used in the assessment), and environmental tracers. The data obtained from these samples (with the exception of the pesticide data) were used to gain insights into processes controlling the groundwater movement through the groundwater system in the study area. Results from the geophysical and geochemical assessments facilitated the interpretation of the geochemical characteristics of the groundwater sources and geochemical groups within the groundwater system.The groundwater-flow system in the study area consists primarily of the Mesilla Basin aquifer system, which can be divided into four hydrogeologic units by using an informal classification scheme based on basin-fill stratigraphy and sedimentology with an emphasis on aquifer characteristics. The four hydrogeologic units are (1) the Rio Grande alluvium, which is the shallow aquifer of the Mesilla Basin within the confines of the Mesilla Valley, and the three hydrogeologic units that compose the Santa Fe Group: (2) the lower part of the Santa Fe Group, which is the least productive zone, (3) the middle part of the Santa Fe Group, which is the primary water-bearing hydrogeologic unit in the basin and is generally saturated, and (4) the upper part of the Santa Fe Group, which is the most productive water-bearing unit within the Santa Fe Group but is only partially saturated in the north and largely unsaturated in the south and western parts of the Mesilla Basin.The helicopter frequency domain electromagnetic survey results indicated that approximately half of the resistivity values were less than 10 ohm-meters at depths of 50 and 100 feet with a transition where the resistivity values changed from relatively high values (greater than 20 ohm-meters) to relatively low resistivity values (less than 10 ohm-meters) near Vado, New Mexico. Slightly more than 25 percent of the gridded resistivity values from the three-dimensional grid of the combined inverse modeling results of the direct-current resistivity and time-domain electromagnetic soundings were equal to or less than 10 ohm-meters with large regions of low resistivity becoming apparent in the southernmost part of the study area near the Paso Del Norte where these low resistivity features are spatially the widest at or below the top of the bedrock. These low resistivity values might represent clayey deposits, sediments composed largely of sand and gravel saturated with saline water, or both. Historical dissolved-solids-concentration data within the surface geophysical subset area of the study area were compiled and compared to the inverse modeling results of the combined direct-current resistivity and time-domain soundings; this comparison was done to strengthen the interpretation made from the combined inverse modeling results that the low resistivity features were representative of sand and gravel deposits saturated with saline water and not clayey deposits.Water-level altitudes within the Rio Grande alluvium generally decreased from north to south, with a west to east decrease in water-level altitudes near Las Cruces, New Mexico, as a result of groundwater pumping. Groundwater flow within the Santa Fe Group is more complex than the groundwater flow within the Rio Grande alluvium because of the larger lateral and vertical extent of the Santa Fe Group compared to the Rio Grande alluvium. Groundwater from the Organ Mountains flows directly south towards the Paso del Norte. Groundwater from the Robledo Mountains, the Rough and Ready Hills, and the Sleeping Lady Hills generally flows to the southeast. Groundwater flowing near the north end of the midbasin uplift generally continues east towards the Rio Grande and then flows south on the east side of the midbasin uplift. Groundwater flowing near the west side of the midbasin uplift generally continues south parallel to the faults that make up the midbasin uplift and then flows east towards the Paso del Norte when it reaches the south end of the midbasin uplift. Groundwater from the Aden Hills and the East and West Potrillo Mountains flows to the south end of the midbasin uplift and then continues east towards the Paso del Norte. Throughout most of the Mesilla Valley, the vertical hydraulic gradient was downward because the water-level altitude in the Rio Grande alluvium was higher than it was in the Santa Fe Group, but in some areas (typically in the middle and southern parts of the Mesilla Valley), the vertical hydraulic gradient was substantially reduced or even reversed to an upward hydraulic gradient.The geochemistry data indicate that there was a complex system of multiple geochemical endmembers and mixing between these endmembers with recharge to the Rio Grande alluvium and Santa Fe Group composed mostly of seepage from the Rio Grande, inflows from deeper or neighboring water systems, and mountain-front recharge. Five distinct geochemical groups were identified in the Mesilla Basin study area: (1) ancestral Rio Grande (pre-Pleistocene) geochemical group, (2) modern Rio Grande (Pleistocene to present) geochemical group, (3) mountain-front geochemical group, (4) deep groundwater upwelling geochemical group, and (5) unknown freshwater geochemical group. The ancestral Rio Grande groundwater was water that recharged into the system as seepage losses from the ancestral Rio Grande; this groundwater generally flows from north to south-southeast towards the Paso del Norte. Groundwater on the west side of the midbasin uplift generally flows south until it reaches the southern part of the study area; from the southern part of the study area, the groundwater flows east towards the Paso del Norte. Groundwater on the east side of the midbasin uplift flows south-southeast towards the Paso del Norte where it mixes with groundwater from the modern Rio Grande, uplifted areas in the west, and the deep saline source. The water type of the modern Rio Grande geochemical group ranged from calcium-sulfate water type in the northern part of the study area to sodium-chloride-sulfate water type in the southern part of the study area; from north to south there was a substantial increase in specific conductance, strontium-87/strontium-86 ratio, potassium, and the trace metals of iron and lithium, changing the water chemistry such that it became similar to the water chemistry of the deep groundwater upwelling geochemical group. From age-dating results, water in the modern Rio Grande geochemical group was recharged to the Rio Grande alluvium within the past 10 years. The mountain-front geochemical group was generally old water (apparent age was greater than 10,000 carbon-14 years before present) that was somewhat mineralized and has relatively high concentrations of fluoride and silica, which might indicate longer exposure to volcanic and siliciclastic rocks or aluminosilicate minerals. There were five different locations of recharge determined from the groundwater geochemistry within the mountain-front geochemical group, all having a slightly different geochemical signature: (1) the Rough and Ready Hills, Robledo Mountains, and the Sleeping Lady Hills, (2) the Doña Ana Mountains, (3) the Aden Hills and West Potrillo Mountains, (4) the East Potrillo Mountains, and (5) the Sierra Juárez in Mexico. The groundwater from the Rough and Ready Hills, Robledo Mountains, the Sleeping Lady Hills, and the Doña Ana Mountains generally flows toward the Rio Grande and eventually mixes together and with the modern Rio Grande groundwater. The groundwater originating from the Aden Hills and East and West Potrillo Mountains generally flows east to southeast at a slow rate and eventually mixes and continues east, where it mixes with groundwater from the ancestral Rio Grande geochemical group and with the groundwater from the Sierra Juárez. The groundwater from the Sierra Juárez flows north and then east towards the Paso del Norte where it mixes with groundwater from the uplifted areas in the west, ancestral and modern Rio Grande groundwater, and the upwelling groundwater from a deep saline source. The deep groundwater upwelling geochemical group had the highest concentrations of bicarbonate, potassium, silica, aluminum, iron, and lithium within the study area, indicating that it had been in contact with carbonate and siliciclastic rocks for a much longer period of time and at higher temperatures compared to the other geochemical groups, and was most likely ancient marine groundwater originating from the Paleozoic and Cretaceous carbonate rocks which was upwelling into the Mesilla Basin aquifer system in the southeastern part of the study area through the extensive fault systems. Direct-current resistivity and time-domain electromagnetic soundings support the interpretation of ancient marine groundwater upwelling into the Mesilla Basin aquifer system, as do the analytical results from wells, and the helicopter frequency domain electromagnetic data collected along the Rio Grande. The hydrogen-2/hydrogen-1 ratio and oxygen-18/oxygen-16 ratio isotopic results for samples in the unknown freshwater geochemical group did not plot on the Rio Grande evaporation line, indicating this group did not have a Rio Grande signature (that is, there was no isotopic evidence of a component of Rio Grande water) and it also had the lowest mineralized content of any geochemical group in the study area.

Epidemiological study of scorpion stings in the Rio Grande do Norte State, Northeastern Brazil

PubMed Central

de Araújo, Kaliany Adja Medeiros; Tavares, Aluska Vieira; Marques, Michael Radan de Vasconcelos; Vieira, Alecxandro Alves; Leite, Renner de Souza

2017-01-01

ABSTRACT This communication is a retrospective epidemiological study of the scorpion sting cases recorded from 2007 to 2014 in the Rio Grande do Norte State, Northeastern Brazil. The data was collected from the Injury Notification Information System database of the Health Department of Rio Grande do Norte State. A total of 20,555 cases were studied. The cases were distributed over all months of the period studied and occurred mainly in urban areas. Victims were predominantly 20-29 year-old women. Most victims were stung on the foot and received medical care within 1-3 h after being stung. The cases were mostly classified as mild and progressed to cure. Scorpion stings in Rio Grande do Norte State are an environmental public health problem that needs to be monitored and controlled throughout the year. PMID:28793026

Crumble analysis of the historic sympatric distribution between Dendrortyx macroura and D. barbatus (Aves: Galliformes)

PubMed Central

2017-01-01

In Mexico, the Long-tailed Wood-Partridge (Dendrortyx macroura) is distributed in the mountains of the Trans-Mexican Volcanic Belt, Sierra Madre del Sur and Sierra Norte de Oaxaca; while the Bearded Wood-Partridge (D. barbatus) is distributed in the Sierra Madre Oriental (SMO). There is a controversial overlap in distribution (sympatry) between these two species (on the Cofre de Perote and Pico de Orizaba volcanoes, SMO and Sierra Norte de Oaxaca), based on the ambiguity and current lack of information regarding the distribution of these two species. In order to disentangle the possible presence of both species in the area of sympatry, we conducted a crumble analysis of the historic knowledge regarding the geographic distribution of both species, based on a review of scientific literature, database records, the specimen examination (in ornithological collections), field work and a reconstruction of the distribution range based on Ecological Niche Modeling. Our results support the presence of only one of these two species in the overlapping area, rejecting the existence of such an area of sympatry between the two species. We discuss alternative hypotheses that could explain the historically reported distribution pattern: 1) an error in the single existing historical record; 2) a possible local extinction of the species and 3) the past existence of interspecific competition that has since been resolved under the principle of competitive exclusion. We propose that the Santo Domingo River in northern Oaxaca and western slope of the Sierra Madre Oriental, mark the distribution limits between these species. PMID:28863140

High resolution 40AR/39AR chronostratigraphy of the Late Cretaceous El Gallo Formation, Baja California del Norte, Mexico

NASA Astrophysics Data System (ADS)

Renne, Paul R.; Fulford, Madeleine M.; Busby-Spera, Cathy

1991-03-01

Laser probe 40Ar/39Ar analyses of individual sanidine grains from four tuffs in the alluvial Late Cretaceous (Campanian) El Gallo Formation yield statistically distinct mean dates ranging from 74.87±0.05 Ma to 73.59±0.09 Ma. The exceptional precision of these dates permits calculation of statistically significant sediment accumulation rates that are much higher than passive sediment loading would cause, implying rapid tectonically induced subsidence. The dates bracket tightly the age of important dinosaur and mammalian faunas previously reported from the El Gallo Formation. The dates support an age less than 73 Ma for the Campanian/Maastrichtian stage boundary, younger than indicated by several currently used time scales. Further application of the single grain 40Ar/39Ar technique may be expected to greatly benefit stratigraphic studies of Mesozoic sedimentary basins and contribute to calibration of biostratigraphic and magnetostratigraphic time scales.

International Workshop on First Decadal Review of the Edgeworth-Kuiper Belt: Toward new Frontiers

NASA Astrophysics Data System (ADS)

Hainaut, O.

2003-06-01

On March 11 to 14, 2003, an international conference on the Minor Bodies in the Outer Solar System was held in Antofagasta, Chile. The conference, which was organized by ESO and Universidad Catolica del Norte (UCN) of Antofagasta, gathered about 70 participants from 20 countries. Originally, it was supposed to take place on the UCN campus. However, a student strike forced us to relocate at the last minute to the Carrera Club Hotel. Thanks to the efforts of A. Lagarini, the conference secretary (and ESO/Chile Science secretary) and to the Hotel staff, this did not cause any disruption. The traditional group photo (opposite) was shot in front of the Geological Museum of UCN. This short summary highlights some of the results presented at this conference; the proceedings, which are currently being edited, will be published as a special issue of “Earth, Moon and Planets.”

Emergent and Reemergent Arboviruses in South America and the Caribbean: Why So Many and Why Now?

PubMed

Marcondes, Carlos Brisola; Contigiani, Marta; Gleiser, Raquel Miranda

2017-05-01

Varios arbovirus han emergido y/o reemergido en el Nuevo Mundo en las últimas décadas. Los virus Zika y chikungunya, anteriormente restringidos a África y quizás Asia, invadieron el continente, causando gran preocupación; además siguen ocurriendo brotes causados por el virus dengue en casi todos los países, con millones de casos por año. El virus West Nile invadió rápidamente América del Norte, y ya se han encontrado casos en América Central y del Sur. Otros arbovirus, como Mayaro y el virus de la encefalitis equina del este han aumentado su actividad y se han encontrado en nuevas regiones. Se han documentado cambios en la patogenicidad de algunos virus que conducen a enfermedades inesperadas. Una fauna diversa de mosquitos, cambios climáticos y en la vegetación, aumento de los viajes, y urbanizaciones no planificadas que generan condiciones adecuadas para la proliferación de Aedes aegypti (L.), Culex quinquefasciatus Say y otros mosquitos vectores, se han combinado para influir fuertemente en los cambios en la distribución y la incidencia de varios arbovirus. Se enfatiza la necesidad de realizar estudios exhaustivos de la fauna de mosquitos y modificaciones de las condiciones ambientales, sobre todo en las zonas urbanas fuertemente influenciadas por factores sociales, políticos y económicos. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Human migration, railways and the geographic distribution of leprosy in Rio Grande do Norte State – Brazil

PubMed Central

Nobre, Mauricio Lisboa; Dupnik, Kathryn Margaret; Nobre, Paulo José Lisboa; De Souza, Márcia Célia Freitas; Dűppre, Nádia Cristina; Sarno, Euzenir Nunes; Jerŏnimo, Selma Maria Bezerra

2016-01-01

Summary Introduction Leprosy is a public health problem in Brazil where 31,044 new cases were detected in 2013. Rio Grande do Norte is a small Brazilian state with a rate of leprosy lower than other areas in the same region, for unknown reasons. Objectives We present here a review based on the analysis of a database of registered leprosy cases in Rio Grande do Norte state, comparing leprosy's geographic distribution among municipalities with local socio-economic and public health indicators and with historical documents about human migration in this Brazilian region. Results The current distribution of leprosy in Rio Grande do Norte did not show correlation with socio-economic or public health indicators at the municipal level, but it appears related to economically emerging municipalities 100 years ago, with spread facilitated by railroads and train stations. Drought-related migratory movements which occurred from this state to leprosy endemic areas within the same period may be involved in the introduction of leprosy and with its present distribution within Rio Grande do Norte. Conclusions Leprosy may disseminate slowly, over many decades in certain circumstances, such as in small cities with few cases. This is a very unusual situation currently and a unique opportunity for epidemiologic studies of leprosy as an emerging disease. PMID:26964429

Investigating the relationship between climate teleconnection patterns and soil moisture variability in the Rio Grande/Río Bravo del Norte basin using the NOAH land surface model

NASA Astrophysics Data System (ADS)

Khedun, C. P.; Mishra, A. K.; Bolten, J. D.; Giardino, J. R.; Singh, V. P.

2010-12-01

Soil moisture is an important component of the hydrological cycle. Climate variability patterns, such as the Pacific Decadal Oscillation (PDO), El Niño Southern Oscillation (ENSO), and Atlantic Multidecadal Oscillation (AMO) are determining factors on surface water availability and soil moisture. Understanding this complex relationship and the phase and lag times between climate events and soil moisture variability is important for agricultural management and water planning. In this study we look at the effect of these climate teleconnection patterns on the soil moisture across the Rio Grande/Río Bravo del Norte basin. The basin is transboundary between the US and Mexico and has a varied climatology - ranging from snow dominated in its headwaters in Colorado, to an arid and semi-arid region in its middle reach and a tropical climate in the southern section before it discharges into the Gulf of Mexico. Agricultural activities in the US and in northern Mexico are highly dependent on the Rio Grande and are extremely vulnerable to climate extremes. The treaty between the two countries does not address climate related events. The soil moisture is generated using the community NOAH land surface model (LSM). The LSM is a 1-D column model that runs in coupled or uncoupled mode, and it simulates soil moisture, soil temperature, skin temperature, snowpack depth, snow water equivalent, canopy water content, and energy flux and water flux of the surface energy and water balance. The North American Land Data Assimilation Scheme 2 (NLDAS2) is used to drive the model. The model is run for the period 1979 to 2009. The soil moisture output is validated against measured values from the different Soil Climate Analysis Network (SCAN) sites within the basin. The spatial and temporal variability of the modeled soil moisture is then analyzed using marginal entropy to investigate monthly, seasonal, and annual variability. Wavelet transform is used to determine the relation, phase difference, and lag times between climate teleconnection events and soil moisture. The results from this study will help agricultural scientists and water planners in both the US and Mexico in better managing the dwindling water resources of this transboundary basin.

Assessing the Cytotoxicity of Black Carbon As A Model for Ultrafine Anthropogenic Aerosol Across Human and Murine Cells: A Chronic Exposure Model of Nanosized Particulate Matter

NASA Astrophysics Data System (ADS)

Salinas, E.

2015-12-01

Combustion-derived nanomaterials or ultrafine (<1 μm) atmospheric aerosols are primarily products of anthropogenic activities, such as the burning of fossil fuels. Ultrafine particles (UFPs) can absorb other noxious pollutants including volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs), toxic organic compounds, and heavy metals. The combination of high population density, meteorological conditions, and industrial productivity brings high levels of air pollution to the metropolitan area of El Paso, Texas, USA/ Ciudad Juarez, Chihuahua, Mexico, comprising the Paso del Norte air basin. A study conducted by scientists from the Research Triangle Park in North Carolina, analyzed sites adjacent to heavy-traffic highways in El Paso and elucidated higher UFP concentrations in comparison to previously published work exploring pollution and adverse health effects in the basin. UFPs can penetrate deep into the alveolar sacs of the lung, reaching distant alveolar sacs and inducing a series of immune responses that are detrimental to the body: evidence suggests that UFPs can also cross the alveolar-blood barrier and potentially endanger the body's immune response. The physical properties of UFPs and the dynamics of local atmospheric and topographical conditions indicate that emissions of nanosized carbonaceous aerosols could pose significant threats to biological tissues upon inhalation by local residents of the Paso del Norte. This study utilizes Black Carbon (BC) as a model for environmental UFPs and its effects on the immunological response. An in vitro approach is used to measure the ability of BC to promote cell death upon long-term exposure. Human epithelial lung cells (A549), human peripheral-blood monocytes (THP-1), murine macrophages (RAW264.7), and murine epithelial lung cells (LA-4) were treated with BC and assessed for metabolic activity after chronic exposure utilizing three distinct and independent cell viability assays. The cell viability experiments included a chronic study at 7, 10, and 14 days of UFP exposure at six different concentrations of BC: 100μM, 300μM, 600μM, 1,250μM, 2,500μM, and 5,000μM conducting the Trypan Blue (TB) Exclusion Assay, Calcein-AM Viability Assay, and CellTiter-Glo Viability Assay.

Solid waste management in Linamon, Lanao del Norte

NASA Astrophysics Data System (ADS)

Paragoso, Glaiza P.; Sapar, Cherine Mae A.; Magsayo, Joy R.; Lahoylahoy, Myrna E.; Guarin, Rica Mae B.

2018-01-01

In this modern world, Solid Waste Management is very important in maintaining a high quality of life so humans must manage and store waste efficiently and safely. Almost every day each household generates garbage or wastes. People throw things improperly without knowing the consequences. The main objective of the study was to assess the residents' Solid Waste Management. Specifically, it aimed to answer the following questions: What is the profile of the respondents in terms of age, gender, educational attainment, occupation, monthly income, no. of household member; What is the knowledge of the respondents about Natural Environment?; How do respondents disposed garbage from the household?; What is the level of the respondents concern about proper waste management?; What is the willingness of the respondents to participate in proper Solid Waste Management?; What is the attitude of the respondents towards the Solid Waste Management? The said study was conducted at the Municipality of Linamon, which is a 5th class municipality located at the Eastern Gateway to Lanao del Norte, a south western Province of Northern Mindanao in the Philippines. The study was conducted in the 8 barangays of the Municipality of Linamon, namely: Bosque, Larapan, Mago-ong, Napo, Poblacion, Purakan, Robocon, and Samburon. The Municipality has 3 urban barangays and 4 rural barangays. The study revealed that most of the respondents interviewed were housewives. Out of 313 respondents, 67.10 % did not understand the term natural environment, with major issue currently affecting natural environment as "household garbage'. The respondents dispose the yard trimmings and papers through burning. The plastic and glass is disposed through the garbage truck. The metals and damaged home appliances were disposed by selling it to the junk shop. The respondents disposed their garbage into an open container specifically in a sack, collected by garbage trucks. The study also revealed that the respondents were highly concerned about waste management and willing to participate in proper solid waste management, with attitudes towards solid waste management as highly positive. The researchers recommend initiating educational campaigns for the general public to raise awareness of the natural environment in order to fully understand the term. Incorporate environmental education into school curriculum to raise awareness and develop environmental attitudes in the large youth community.

Exploration of an alluvial aquifer in Oman by time-domain electromagnetic sounding

NASA Astrophysics Data System (ADS)

Young, M. E.; de Bruijn, R. G. M.; Al-Ismaily, A. Salim

One-third of the population of Oman depends upon groundwater extracted from the alluvium of the Batinah Plain, on the coast of the Gulf of Oman. Deep geophysical exploration techniques were used to determine the depth and nature of the alluvium and the boundaries of the aquifer. The base and structural controls of the alluvial basin at its contact with Tertiary marine sediments and Cretaceous ophiolite were mapped with seismic reflection data, recorded originally for oil exploration. The base of the alluvium dips northward from the foothills of the Northern Oman Mountains, reaching a maximum depth of 2000m at the coast. The varying facies of the alluvium are grossly characterised by different, overlapping ranges of electrical resistivity, depending largely on the clay content and degree of cementation. Resistivities near the coast are reduced by saline intrusion. These variations of resistivity were mapped with time-domain electromagnetic sounding along 400km of profile, to distinguish among the three zones of the alluvial aquifer. The wedge of saline intrusion was also delineated, up to 10km from the coast. The thickness of the saturated gravel aquifer ranges from 20-160m in an area greater than 600km2. Résumé Un tiers de la population d'Oman est alimenté par de l'eau souterraine pompée dans les alluvions de la plaine de Batinah, sur la côte du golfe d'Oman. Des techniques d'exploration géophysique profonde ont été mises en oeuvre pour déterminer la profondeur et la nature des alluvions et les limites de l'aquifère. La base et les contrôles structuraux du bassin alluvial au contact des sédiments marins tertiaires et des ophiolites crétacées ont été cartographiés à partir des données de sismique réflexion obtenues à l'origine pour la recherche pétrolière. La base des alluvions plonge vers le nord à partir du piémont du massif septentrional d'Oman, pour atteindre une profondeur maximale de 2000m sur la côte. Les divers faciès alluviaux sont grossièrement caractérisés par des différentes gammes de résistivitéélectrique se recouvrant, dépendant surtout de la teneur en argiles et du degré de cimentation. Les résistivités près de la côte diminuent du fait de l'intrusion marine. Ces variations de résistivité ont été cartographiées à partir de 400km de profils électromagnétiques, dans le domaine temporel ; trois zones ont été distinguées dans l'aquifère alluvial. Le biseau salé a aussi été délimité, jusqu'à 10km de la côte. L'épaisseur de la partie saturée des graviers va de 20-160m sur une étendue supérieure à 600km2. Resumen Un tercio de la población de Omán depende de las aguas subterráneas extraídas del aluvial de la Llanura de Batinah, en la costa del Golfo de Omán. Para determinar la profundidad y naturaleza del aluvial, así como los límites del acuífero, se han usado técnicas de exploración geofísica profunda. El basamento y los límites estructurales del aluvial en su contacto con los sedimentos marinos del Terciario y la ofiolita cretácica se obtuvieron mediante sísmica de reflexión, registrada previamente en campañas de exploración petrolífera. La base del aluvial buza hacia el norte desde el pie de las Montañas del Norte de Omán, alcanzando una profundidad máxima de 2000m en la costa. Las distintas facies del aluvial están caracterizadas por rangos distintos, pero superpuestos, de resistividad eléctrica, dependiendo del contenido en arcillas y del grado de cementación. Las resistividades cerca de la costa se reducen por la intrusión salina. Estas variaciones de resistividad se obtuvieron con registros electromagnéticos a lo largo de un perfil de 400km, con el objetivo de distinguir las tres zonas del acuífero aluvial. También se pudo obtener la geometría de la cuña de intrusión, que llega hasta 10km de la costa. El espesor de las gravas saturadas que forman el acuífero oscila entre los 20-160m en un área superior a 600km2.

Physical Properties of the SKYLAB North Polar Coronal Hole with an Extended Base and its MHD Self-Consistent Modelling

NASA Astrophysics Data System (ADS)

Bravo, S.; Ocania, G.

1991-04-01

RESUMEN Con base en las observaciones del Skylab del Sol en rayos X que permitieron r la forma de la frontera del hoyo coronal del polo norte y en las observaciones de l 'z que permitieron derivar un perfil de densidad para el flujo de viento solar (IC ese hoyo, Murno yjackson (1977) concluyeron que se requiere una adici6n t l clc energfa al flujo hasta al menos 5 R8. En este trabajo, recalculamos los perfiles de y de temperatura para el mismo hoyo pero considerando una frontera Cs mas ancha en la base, de acuerdo con las observaciones del coron6metro-K del IIAO, los espectroheliogramas en EUV del OSO-7 y las fotografias de la corona solar cerca de los 4 E)()O A. Se tomaron tambien las incertidumbres en el perfil de densidad electr6nica inl & a las observaciones de luz blanca y se consideraron diversos valores posibles dCl fl 'jo (lC masa 1 UA. Encontramos que las diferencias introducidas no son suficientes par clcsc' la necesidad de una energetizaci6n extensa del viento solar, pero una dC las s posibles muestra una concordancia muy buena con el modelado MHD (l( l flujo con el unico t6rmino adicional de la fuerza de Lorentz en la ecuaci6n de # (). ABSTRACT Based on the near to the Sun boundary of the Skylab north polar coroi ' l estimated from the AS & E X-ray photographs and on the density profile fi-C)I white light data, Munro and Jackson (1977) concluded that substantial energy the solar wind flux is required up to at least 5 Rs. In this paper we recalculate `eloci y and temperature profiles for the same hole but considering a different bo ' ry for flux tube which is larger at its base, according to the HAO K- obser"' (i()I0 , the OSO-7 EUV spectroheliograms and pictures of the solar 4500 A. è take into account the uncertainties inherent in the white light observations () electron density profile and consider different possible values of the solar I .' fltix at 1 AU. We that the differences introduced are not sufficient to discard ii y of an extended energetization of the wind, one of the possibilities allowed for fltix the observational uncertailities shows a very good agreement wi4 an NI Ill) seli'consistent modelling with the only additional term of the Lorentz force in the iiii equation. Key words: SUN-CORONA

Assessment of potential shale gas and shale oil resources of the Norte Basin, Uruguay, 2011

USGS Publications Warehouse

Schenk, Christopher J.; Kirschbaum, Mark A.; Charpentier, Ronald R.; Cook, Troy; Klett, Timothy R.; Gautier, Donald L.; Pollastro, Richard M.; Weaver, Jean N.; Brownfield, Michael

2011-01-01

Using a performance-based geological assessment methodology, the U.S. Geological Survey estimated mean volumes of 13.4 trillion cubic feet of potential technically recoverable shale gas and 0.5 billion barrels of technically recoverable shale oil resources in the Norte Basin of Uruguay.

Astronomy in Syria

NASA Astrophysics Data System (ADS)

Al-Mousli, A. T.

2006-11-01

Syria has been involved in the field of astronomy since 1997, when Prof. F.R. QUERCI, France, visited Syria and made a presentation on the International NORT project; (NORT: the Network of Oriental Robotic Telescope), which was a selected project of the sixth United Nations/ European Space Agency Workshop on Basic Space Science (document no. A/AC.105/657 dated 13/12/1996). NORT aims to establish a robotic telescope network on high mountain peaks around the Tropic of Cancer, from Morocco in the west to the desert of China in the east. The purposes for establishing this network are technical and educational. The General Organization of Remote Sensing (GORS) has carried out a pilot study using remote sensing techniques and has selected four sites in order to determine the best location for the astronomical observatory the within NORT programme. Following this project, GORS decided to establish an office for astronomical studies, one of the earliest works of GORS in astronomy was an initiative to establish a planetarium within the GORS campus, to accommodate approximately 120 observers. A contest to choose the best planetarium design, for the Arab World, took place at GORS.

Attic Dust Analysis Approach for Evaluation of Heavy Metal Deposition on the El Paso Del Norte Region

NASA Astrophysics Data System (ADS)

Shekhter, E. G.; van Pelt, S.; Pannell, K.; Gill, T. E.; Barnes, M. A.

2010-12-01

The El Paso del Norte region in the United States is a region of complex topography that is the home to more than 2 million people who share the same air. A large non-ferrous smelter (primary lead-copper smelter),owned by the American Smelting and Refining Company (ASARCO), was functioning in the Rio Grande River valley on the west side of the Franklin Mountains that divide the city of El Paso and across the river from Juarez, Mexico’s largest city on the United States border. During the more than 100 years of operation, beginning in 1887, the ASARCO smelter emissions considerably deteriorated the already complex environmental condition on the US-Mexican border. In order to identify the sources and patterns of heavy metal dispersion, we used an attic dust analyses approach which has not been previously been applied in this area. Undisturbed attic dust can provide an integrated history of atmospheric loading of particulates emanating from geological, biological and anthropogenic sources and can help to reconstruct the air pollution history on a local scale. We sampled attic dust and dust from undisturbed surfaces in 15 buildings of varying ages from three neighborhoods in the cities of El Paso and Juarez. The dust samples and samples of unpolluted buried soil horizons in the area were extracted with aqua regia and analyzed by ICP-AES and ICP-MS. Enrichment ratios (ER) were calculated by dividing the concentration of a trace metal in the attic dust by the mean concentration of the same element in the buried soil horizons. Mean ER for Pb were 263.3, 95.4, and 70.2 for dust collected in a neighborhood near the smelter, downtown Juarez, and an El Paso neighborhood on the other side of the Franklin Mountains from the smelter. Greater ER for As, Cd, Zn, Sb, and Cu followed the same trends, by neighborhood, noted for Pb. In addition, dust collected from attics surfaces (pipes, ducts, storage containers) post-dating smelter disclosure had lower ER for the trace metals than samples collected on adjacent surfaces that were present during the period of smelter operation. Based on the evidence provided by dust chemistry, we conclude that heavy metal contamination was predominantly from smelter stack emissions, was preferentially deposited on the near field, and generally followed the lower path provided by Rio Grande valley rather than mixing to heights that could result in movement over the Franklin Mountains and deposition on the east side of El Paso.

Cascadia Earthquake and Tsunami Scenario for California's North Coast

NASA Astrophysics Data System (ADS)

Dengler, L.

2006-12-01

In 1995 the California Division of Mines and Geology (now the California Geological Survey) released a planning scenario for an earthquake on the southern portion of the Cascadia subduction zone (CSZ). This scenario was the 8th and last of the Earthquake Planning Scenarios published by CDMG. It was the largest magnitude CDMG scenario, an 8.4 earthquake rupturing the southern 200 km of the CSZ, and it was the only scenario to include tsunami impacts. This scenario event has not occurred in historic times and depicts impacts far more severe than any recent earthquake. The local tsunami hazard is new; there is no written record of significant local tsunami impact in the region. The north coast scenario received considerable attention in Humboldt and Del Norte Counties and contributed to a number of mitigation efforts. The Redwood Coast Tsunami Work Group (RCTWG), an organization of scientists, emergency managers, government agencies, and businesses from Humboldt, Mendocino, and Del Norte Counties, was formed in 1996 to assist local jurisdictions in understanding the implications of the scenario and to promote a coordinated, consistent mitigation program. The group has produced print and video materials and promoted response and evacuation planning. Since 1997 the RCTWG has sponsored an Earthquake Tsunami Education Room at county fairs featuring preparedness information, hands-on exhibits and regional tsunami hazard maps. Since the development of the TsunamiReady Program in 2001, the RCTWG facilitates community TsunamiReady certification. To assess the effectiveness of mitigation efforts, five telephone surveys between 1993 and 2001 were conducted by the Humboldt Earthquake Education Center. A sixth survey is planned for this fall. Each survey includes between 400 and 600 respondents. Over the nine year period covered by the surveys, the percent with houses secured to foundations has increased from 58 to 80 percent, respondents aware of a local tsunami hazard increased from 51 to 73 percent and knowing what the Cascadia subduction zone is from 16 to 42 percent. It is not surprising that the earlier surveys showed increases as several strong earthquakes occurred in the area between 1992 and 1995 and there was considerable media attention. But the 2001 survey, seven years after the last widely felt event, still shows significant increases in almost all preparedness indicators. The 1995 CDMG scenario was not the sole reason for the increased interest in earthquake and tsunami hazards in the area, but the scenario gave government recognition to an event that was previously only considered seriously in the scientific community and has acted as a catalyst for mitigation and planning efforts.

Surf Zone Sediment Size Variation, Morphodynamics, and Hydrodynamics During Sea/Land Breeze and El-Norte Storm in Sisal, Yucatan, Mexico

NASA Astrophysics Data System (ADS)

Alrushaid, T.; Figlus, J.; Torres-Freyermuth, A.; Puleo, J. A.; Dellapenna, T. M.

2016-02-01

Coastlines around the world are under ever-increasing pressure due to population trends, commerce, and geophysical processes like tropical storms and erosion. This multi-institutional field campaign was conducted to improve our understanding of complex nearshore processes under varying forcing conditions on a microtidal, sandy beach located in Sisal, Yucatan from 3/27 to 4/12/2014. Hydrodynamics, morphodynamics, and textural variability were investigated during: (1) a cold front event (referred to as El-Norte); (2) land breeze (LB); and (3) sea breeze (SB). The instrumentation layout included three surf/swash zone cross-shore transects where water elevation, suspended sediment concentration, bed load, and current velocities were measured, as well as several offshore ADCP for hydrodynamic measurements. TKE, τb, ɛ and were estimated using the data obtained from surf zone ADV. In addition, Hs and Tsin the surf zone were computed using measurements from ADV pressure sensors, while a separate pressure transducer was used to obtain water free-surface elevation within the swash zone. During SB cycles the study area experienced wind velocities reaching up to 12ms-1, and 15ms-1 during El-Norte. Elevated wind stress during El-Norte resulted in Hs of 1.5m and 0.6m in water depths of 10m and 0.4m, respectively. Surface sediment grab samples during SB/LB cycles showed that the swash zone had a moderately well sorted distribution with a mean grain size of 0.5mm, while poor sorting and a mean grain size of 0.7mm were found during El-Norte. Additionally, measured bathymetry data showed evidence for offshore sandbar migration during strong offshore currents (0.4ms-1) during El-Norte, while onshore sandbar migration was evident during SB/LB periods (0.3ms-1 and 0.1ms-1, respectively). This study highlights how different weather forcing conditions affect hydrodynamics, morphodynamics, and textural variability on a sandy beach. Aside from furthering our knowledge on these complex processes, the findings may lead to improved coastal management strategies for sandy coastlines.

Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil

PubMed Central

Cabral, Cynthia Hatsue Kitayama; Serafim, Édvis Santos Soares; de Medeiros, Waleska Rayane Dantas Bezerra; de Medeiros Fernandes, Thales Allyrio Araújo; Kimura, Elza Miyuki; Costa, Fernando Ferreira; de Fátima Sonati, Maria; Rebecchi, Ivanise Marina Moretti; de Medeiros, Tereza Maria Dantas

2011-01-01

βS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte. PMID:21931513

Calha Norte: Explaining Brazilian Army Presence in the Amazon

DTIC Science & Technology

1993-06-01

the Yanomami Indians.""’ The potential wealth present in the Calha Norte region has been estimated at over US$134 billion, enough to repay almost all...garimpeiros to remain on Yanomami land was essentially a military decision. The Army’s pro-miner position was highlighted by official statements made by the...Environmental Policy and Military Geopolitics in the Development of the Brazilian Amazon: The Case of the Yanomami ," Development and Change (1992

Osprey distribution, abundance, and status in western North America: I. The northern California population

USGS Publications Warehouse

Henny, Charles J.; Dunaway, David J.; Mallette, Robert D.; Koplin, James R.

1978-01-01

An estimated 355± 40 pairs (95 percent C.I.) of Ospreys (Pandion haliaetus carolinensis) nested in the northern California survey area in 1975. Eighty-one pairs were estimated along the extreme northern coast in Del Norte and Humboldt Counties. One hundred and forty-four pairs were estimated along California's northern coast in Mendociuo, Sonoma, and Marin Counties. The northern interior region, primarily in Siskiyou, Trinity, Shasta, Lassen, and Plumas Counties, contained an estimated 130 pairs. Forty-nine percent of the interior Osprey population is associated with reservoirs that were not present in 1900. We believe more Ospreys are present in the interior now than 75 years ago because of the increase in suitable habitat; nevertheless, populations at Shasta Lake and Clair Engle Lake are now exhibiting below-normal production rates and local declines. The long-term status of the coastal population, nesting along rivers, streams, and bays, is not clear. Recent production rates from two segments of the coastal population appear to be normal, but production at Usal Creek is below normal.

Earth observations taken during STS-77 mission

NASA Image and Video Library

1996-05-21

STS077-707-097 (19-29 May 1996) --- This 70mm photograph shows the contrasts between the Chihuahua Desert and the irrigated bottomlands of the Rio Grande. The twin cities of Juarez, Mexico, and El Paso, Texas, on opposite sides of the border are in the center of the frame. The area was first colonized in 1598 making it one of the oldest settlements of Europeans on the North American continent. The name of El Paso derives from the Spanish ?El Paso del Norte.? The City of El Paso became a United States city in 1873. The pass allows passage through the Rocky Mountains in this region. The extension of the Rockies to the northwest of El Paso is known as the Franklin Mountains. Juarez now has over a million people and El Paso has around 400,000. The economy is driven by the maquiladora industries. Fort Bliss on the United States side is a major employer also. Fort Bliss is the wedge shaped feature in El Paso. The post was first established in 1849 for protection from the Comanches and the last horse Calvary unit was disbanded in 1943.

Mesohabitats, fish assemblage composition, and mesohabitat use of the Rio Grande silvery minnow over a range of seasonal flow regimes in the Rio Grande/Rio Bravo del Norte, in and near Big Bend National Park, Texas, 2010-11

USGS Publications Warehouse

Moring, J. Bruce; Braun, Christopher L.; Pearson, Daniel K.

2014-01-01

There were no statistically significant differences between the stream velocities associated with seine hauls of the Rio Grande silvery minnow and Tamaulipas shiner. Stream velocities associated with the seine hauls that included Rio Grande silvery minnow indicate that this species is predominantly found in low-velocity mesohabitats. Velocities associated with seine hauls that included the Tamaulipas shiner represented a much broader overall range of velocities than those associated with Rio Grande silvery minnow collections. No statistically significant differences were found between the depths for seine hauls that included Rio Grande silvery minnow or Tamaulipas shiner. The Rio Grande silvery minnow was more commonly collected in seine hauls from mesohabitats dominated by cobble substrates and less frequently collected in mesohabitats with substrates dominated by fine-sized silt and clay particles, gravels, and sands, in that order. In contrast, the Tamaulipas shiner was broadly distributed among mesohabitats characterized as having gravel, cobble, and silt and clay.

Nearshore circulation on a sea breeze dominated beach during intense wind events

NASA Astrophysics Data System (ADS)

Torres-Freyermuth, Alec; Puleo, Jack A.; DiCosmo, Nick; Allende-Arandía, Ma. Eugenia; Chardón-Maldonado, Patricia; López, José; Figueroa-Espinoza, Bernardo; de Alegria-Arzaburu, Amaia Ruiz; Figlus, Jens; Roberts Briggs, Tiffany M.; de la Roza, Jacobo; Candela, Julio

2017-12-01

A field experiment was conducted on the northern Yucatan coast from April 1 to April 12, 2014 to investigate the role of intense wind events on coastal circulation from the inner shelf to the swash zone. The study area is characterized by a micro-tidal environment, low-energy wave conditions, and a wide and shallow continental shelf. Furthermore, easterly trade winds, local breezes, and synoptic-scale events, associated with the passage of cold-fronts known as Nortes, are ubiquitous in this region. Currents were measured concurrently at different cross-shore locations during both local and synoptic-scale intense wind events to investigate the influence of different forcing mechanisms (i.e., large-scale currents, winds, tides, and waves) on the nearshore circulation. Field observations revealed that nearshore circulation across the shelf is predominantly alongshore-directed (westward) during intense winds. However, the mechanisms responsible for driving instantaneous spatial and temporal current variability depend on the weather conditions and the across-shelf location. During local strong sea breeze events (W > 10 m s-1 from the NE) occurring during spring tide, westward circulation is controlled by the tides, wind, and waves at the inner-shelf, shallow waters, and inside the surf/swash zone, respectively. The nearshore circulation is relaxed during intense land breeze events (W ≈ 9 m s-1 from the SE) associated with the low atmospheric pressure system that preceded a Norte event. During the Norte event (Wmax≈ 15 m s-1 from the NNW), westward circulation dominated outside the surf zone and was correlated to the Yucatan Current, whereas wave breaking forces eastward currents inside the surf/swash zone. The latter finding implies the existence of large alongshore velocity shear at the offshore edge of the surf zone during the Norte event, which enhances mixing between the surf zone and the inner shelf. These findings suggest that both sea breezes and Nortes play an important role in sediment and pollutant transport along/across the nearshore of the Yucatan shelf.

Checklist of Mosquito Species (Diptera: Culicidae) in the Rio Grande do Norte State, Brazil-Contribution of Entomological Surveillance.

PubMed

Lázaro Silva Inácio, Cássio; Hilário Tavares da Silva, José; César de Melo Freire, Renato; Antonaci Gama, Renata; Brisola Marcondes, Carlos; de Fátima Freire de Melo Ximenes, Maria

2017-05-01

The distribution of mosquito species in Rio Grande do Norte state, Brazil, was compiled from published data mid-2016 and a review of specimens deposited in the entomological collection of the Entomology Laboratory of the Federal University of Rio Grande do Norte. The existing records exist for 40 of the 167 municipalities in the state. The specimens in the Entomology Laboratory were collected using Shannon traps and by active search for immature individuals and from aquatic habitats using standard methods, in preserved Atlantic Forest and Caatinga remnants, located in urban and rural areas of the state. In total were recorded 76 species distributed into 25 subgenera, 15 genera, nine tribes, and two subfamilies, in addition to 15 new species records for the state. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Elevation and mass change of the Echaurren Norte Glacier (Central Andes, Chile) from 1955 to 2015.

NASA Astrophysics Data System (ADS)

Farías, David; Vivero, Sebastián; Casassa, Gino; Seehaus, Thorsten; Braun, Matthias H.

2017-04-01

The Echaurren Norte Glacier (33°34'S 70°07'W) is a small mountain glacier located at the upper Maipo basin, approximately 80 km to Santiago de Chile. The glacier has the longest surface mass balance record in South America (1975 to 2016). The measurements are carried out by DGA (water directory of Chile) using the direct glaciological method. The surface mass balance show continuous negative values, but exceptional positive mass balances were identified during ENSO periods. The aim of our study is complement the in-situ observations on Echaurren Norte Glacier with the geodetic mass balance measurements for the period 1955 to 2015. Our database comprises digital elevation models (DEM) from historical cartography based on aerial photographs (1955), SRTM (2000) and Lidar data. In addition, we mapped changes in glacier extent using aerial photography and multi-mission satellite data. TanDEM-X (2012-2015) and SRTM data will be used to investigate surrounding glaciers that have not such extensive and detailed coverage as Echaurren Norte Glacier. The aerial photographs from 1955 were scanned from the original negative using a photogrammetric scanner and processed on a digital photogrammetric workstation (DPW) and georeferenced with the aid of GCPs derived from the Lidar dataset. The TanDEM-X data was processed using differential interferometry using SRTM C-band DEM as reference. Differences resulting from X- and C-band penetration are considered comparing X- and C-band SRTM data. All DEMs were laterally and vertically co-registered to each other. Error assessment was done over stable ground. Our preliminary results indicate an elevation change of -42.2 m ± 4 m (1955-2015) for Echaurren Norte Glacier. The estimated averaged annual mass balance is -0.59 m water equivalent for the period 1955-2015 using a density of 0.85 kg/cm3 for volume to mass conversion. Significant changes of the surface cover were identified, with a considerable increase of the debris cover, in particular in the medial zone of the glacier with a layer approximately 0.35 m of thickness (2009-2015).

An ethnobotanical study of traditional rice landraces (Oryza sativa L.) used for medical treatment in selected local communities of the Philippines.

PubMed

Cabanting, Rosa Mia F; Perez, Loida M

2016-12-24

Rice (Oryza sativa L.) remains as one the most important staple food of the Philippines with an overabundance of varieties and gastronomic use. Despite this, no published comprehensive ethnobotanical information exists for the exclusive subject on Philippine traditional rice varieties and their ethnomedicinal value. To identify and collect traditional rice landrace with ethnomedicinal application from local communities of the Philippines; and document the application, traditional preparation and administration of these plants. The ethnobotanical study was performed in nine areas distributed across four provinces: Palawan, Zamboanga del Norte, Zamboanga del Sur and North Cotabato for a period of two years (2014-2015). A total of 39 key informants were identified and interviewed using semi-structured interviews and informal discussion. Descriptive statistics was used to analyze and organize the collected information from the surveys. Nineteen (19) traditional rice were identified for the native treatment and control of 22 community health concerns. Predominant use of the plants collected were for the treatment of some types of nutritional disorders (18%), digestive system disorders (18%), ill-defined symptoms (13%); viral infections (13%); and several cultural diseases and disorders (11%). Grains were the most frequently used plant part and oral administration was the most preferred mode of treatment. This study is the first to formally confirm that certain traditional rice have a role in the healthcare system of selected local communities in the Philippines. The novel findings open a paradigm for scientists towards therapeutic investigations and development of probable high value products from the highlighted landrace. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Species profiles: Life histories and environmental requirements of coastal fishes and invertebrates (Pacific Northwest)--ghost and blue mud shrimp

USGS Publications Warehouse

Hornig, S.; Sterling, A.; Smith, Styles

1989-01-01

Geographic range: The ghost shrimp is found in intertidal areas along the west coast of North America from Mutiny Bay, Alaska, to the mouth of the Tijuana River, San Diego County, California; MacGinitie (1934) and Ricketts and Calvin (1968) reported finding specimens as far south as El Estuario de Punto Banda, Baja California Norte, Mexico. The blue mud shrimp is found from southeastern Alaska to San Quentin Bay (Bahia de San Quentin) in Baja California Norte. The general distribution of the two species in the Pacific Northwest is identical (Figure 3).

Anthropophily of Lutzomyia wellcomei (Diptera: Psychodidae) in an Atlantic Forest Conservation Unit in Northeast Brazil.

PubMed

Pinheiro, Marcos Paulo Gomes; Silva, José Hilário Tavares da; Inacio, Cássio Lázaro Silva; Ximenes, Maria de Fátima Freire de Melo

2016-11-01

Lutzomyia wellcomei (Fraiha, Shaw & Lainson) (Diptera: Psychodidae) can act as an important vector of Leishmania (Viannia) braziliensis This study presents the results of collections carried out in a fragment of Atlantic Forest in a Conservation Unit of Rio Grande do Norte state. Collections occurred over 12 consecutive months using Shannon and CDC traps. A total of 777 sand flies from eight species were collected: Lutzomyia walkeri (Newstead), Lutzomyia evandroi (Costa Lima & Antunes), Lutzomyia wellcomei (Fraiha, Shaw & Lainson), Lutzomyia sordellii (Shannon & Del Ponte), Lutzomyia brasiliensis (Costa Lima), Lutzomyia lenti (Mangabeira), Lutzomyia longipalpis (Lutz & Neiva), and Lutzomyia abonnenci (Floch & Chassignet). Lutzomyia wellcomei was the most abundant species using the Shannon trap (97%) and L. walkeri in the CDC trap (81%). It is important to note the abundance of L. wellcomei in Shannon trap collections, which favors the capture of anthropophilic species. Lutzomyia wellcomei was only present in months where rainfall was above 100 mm, confirming it as a species adapted to wetter months. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Chemical analyses of ground-water samples from the Rio Grande Valley in the vicinity of Albuquerque, New Mexico, October 1993 through January 1994

USGS Publications Warehouse

Wilkins, D.W.; Schlottmann, J.L.; Ferree, D.M.

1996-01-01

A study was conducted to investigate general ground-water- quality conditions and contaminant locations in the Rio Grande Valley in the vicinity of Albuquerque, New Mexico. Water samples from 36 observation wells in 12 well nests were analyzed. The well nests are located along three roads near the Rio Grande--two well nests near Paseo del Norte, five well nests near Monta?o Road, and five well nests near Rio Bravo Boulevard. The water samples were collected from October 19, 1993, through January 18, 1994. Water-quality types by major-ion composition were calcium bicarbonate (found in most samples), sodium sulfate, calcium sulfate, and calcium sulfate chloride. Nutrients were detected in all but one sample. Ammonia was detected in 34 samples, nitrite in 4 samples, and nitrate in 17 samples. Orthophosphate was detected in 31 samples. Organic carbon was detected in all samples collected. The trace elements arsenic and barium were detected in all samples and zinc in 31 samples. Fourteen samples contained detectable copper. Cadmium was detected in one sample, chromium in two samples, lead in four samples, and selenium in two samples. Mercury and silver were not detected.

Testing the usefulness of ERTS-1 imagery for inventorying wildland resources in northern California

NASA Technical Reports Server (NTRS)

Lauer, D. T.; Krumpe, P. F.

1973-01-01

The usefulness of ERTS-1 imagery for inventorying wildland resources in northern California is discussed. Studies are being conducted in two large wildland areas, namely, the Feather River Watershed and the Northern Coastal Zone. The 2.5 million-acre Feather River headwaters area in northern California is the keystone watershed for the California Water Project, one of the most extensive and ambitious water resource developments ever attempted. Consequently, accurate and timely information on the quantity, quality and distribution of timber, forage, water and recreational resources is of immediate importance to each public agency and private group managing this vast, but inaccessible, wildland area. The Northern Coastal Zone (consisting of the counties of Marin, Sonoma, Mendicino, Humbolt and Del Norte) is relatively rural, with an economy based on agriculture, timber, commercial fishing and tourism. However, it is expected that intensive resource use resulting from increasing population will soon become a serious problem unless wise land use planning is undertaken. Thus, this coastal region is particularly well suited to investigations of the ways in which ERTS-1 imagery and other supporting data may be used in conducting land use evaluations.

Design and Compilation of a Geodatabase of Existing Salinity Information for the Rio Grande Basin, from the Rio Arriba-Sandoval County Line, New Mexico, to Presidio, Texas, 2010

USGS Publications Warehouse

Shah, Sachin D.; Maltby, David R.

2010-01-01

The U.S. Geological Survey, in cooperation with the U.S. Army Corps of Engineers, compiled salinity-related water-quality data and information in a geodatabase containing more than 6,000 sampling sites. The geodatabase was designed as a tool for water-resource management and includes readily available digital data sources from the U.S. Geological Survey, U.S. Environmental Protection Agency, New Mexico Interstate Stream Commission, Sustainability of semi-Arid Hydrology and Riparian Areas, Paso del Norte Watershed Council, numerous other State and local databases, and selected databases maintained by the University of Arizona and New Mexico State University. Salinity information was compiled for an approximately 26,000-square-mile area of the Rio Grande Basin from the Rio Arriba-Sandoval County line, New Mexico, to Presidio, Texas. The geodatabase relates the spatial location of sampling sites with salinity-related water-quality data reported by multiple agencies. The sampling sites are stored in a geodatabase feature class; each site is linked by a relationship class to the corresponding sample and results stored in data tables.

Snowmelt runoff modeling in simulation and forecasting modes with the Martinec-Mango model

NASA Technical Reports Server (NTRS)

Shafer, B.; Jones, E. B.; Frick, D. M. (Principal Investigator)

1982-01-01

The Martinec-Rango snowmelt runoff model was applied to two watersheds in the Rio Grande basin, Colorado-the South Fork Rio Grande, a drainage encompassing 216 sq mi without reservoirs or diversions and the Rio Grande above Del Norte, a drainage encompassing 1,320 sq mi without major reservoirs. The model was successfully applied to both watersheds when run in a simulation mode for the period 1973-79. This period included both high and low runoff seasons. Central to the adaptation of the model to run in a forecast mode was the need to develop a technique to forecast the shape of the snow cover depletion curves between satellite data points. Four separate approaches were investigated-simple linear estimation, multiple regression, parabolic exponential, and type curve. Only the parabolic exponential and type curve methods were run on the South Fork and Rio Grande watersheds for the 1980 runoff season using satellite snow cover updates when available. Although reasonable forecasts were obtained in certain situations, neither method seemed ready for truly operational forecasts, possibly due to a large amount of estimated climatic data for one or two primary base stations during the 1980 season.

Aerosol characterizaton in El Paso-Juarez airshed using optical methods

NASA Astrophysics Data System (ADS)

Esparza, Angel Eduardo

2011-12-01

The assessment and characterization of atmospheric aerosols and their optical properties are of great significance for several applications such as air pollution studies, atmospheric visibility, remote sensing of the atmosphere, and impacts on climate change. Decades ago, the interest in atmospheric aerosols was primarily for visibility impairment problems; however, recently interest has intensified with efforts to quantify the optical properties of aerosols, especially because of the uncertainties surrounding the role of aerosols in climate change. The main objective of the optical characterization of aerosols is to understand their properties. These properties are determined by the aerosols' chemical composition, size, shape and concentration. The general purpose of this research was to contribute to a better characterization of the aerosols present in the Paso del Norte Basin. This study permits an alternative approach in the understanding of air pollution for this zone by analyzing the predominant components and their contributions to the local environment. This dissertation work had three primary objectives, in which all three are intertwined by the general purpose of the aerosol characterization in the Paso del Norte region. The first objective was to retrieve the columnar aerosol size distribution for two different cases (clean and polluted scenarios) at each season (spring, summer, fall and winter) of the year 2009. In this project, instruments placed in buildings within the University of Texas at El Paso (UTEP) as well as a monitoring site (CAMS 12) from the Texas Commission on Environmental Quality (TCEQ) provided the measurements that delimited the aerosol size distribution calculated by our model, the Environmental Physics Inverse Reconstruction (EPIRM) model. The purpose of this objective was to provide an alternate method of quantifying and size-allocating aerosols in situ, by using the optical properties of the aerosols and inversely reconstruct and retrieve the size distribution of them. This method permits the assessment of aerosols in the ambient in-situ, without physically extracting them from their current state, as the filter technique does. The second objective was an analysis and comparison of the aerosol optical thickness (AOT) data between ground-based instruments and satellite data. In this project, the groundbased instruments are the Multi Filter Rotating Shadowband Radiometers (MFRSR) installed at UTEP and the nearest sun photometer facility, a NASA's Aerosol Robotic Network (AERONET), located at White Sands, New Mexico. The satellite data is provided by the NASA's Multi-angle Imaging Spectro-radiometer (MISR) instrument located in the Terra satellite. Finally, the third objective was to estimate ground particulate matter concentration of particles no greater than 2.5 mum in diameter (PM2.5) by using the MISR's satellite data. This objective was achieved by implementing an empirical mathematical model that includes measured data. In addition, this model addressed the geographic characteristics of the region as well as several factors such as season, relative humidity (RH) and the height of the planetary boundary layer (PBL).

Numerical simulation of vertical ground-water flux of the Rio Grande from ground-water temperature profiles, central New Mexico

USGS Publications Warehouse

Bartolino, James R.; Niswonger, Richard G.

1999-01-01

An important gap in the understanding of the hydrology of the Middle Rio Grande Basin, central New Mexico, is the rate at which water from the Rio Grande recharges the Santa Fe Group aquifer system. Several methodologies-including use of the Glover-Balmer equation, flood pulses, and channel permeameters- have been applied to this problem in the Middle Rio Grande Basin. In the work presented here, ground-water temperature profiles and ground-water levels beneath the Rio Grande were measured and numerically simulated at four sites. The direction and rate of vertical ground-water flux between the river and underlying aquifer was simulated and the effective vertical hydraulic conductivity of the sediments underlying the river was estimated through model calibration. Seven sets of nested piezometers were installed during July and August 1996 at four sites along the Rio Grande in the Albuquerque area, though only four of the piezometer nests were simulated. In downstream order, these four sites are (1) the Bernalillo site, upstream from the New Mexico State Highway 44 bridge in Bernalillo (piezometer nest BRN02); (2) the Corrales site, upstream from the Rio Rancho sewage treatment plant in Rio Rancho (COR01); (3) the Paseo del Norte site, upstream from the Paseo del Norte bridge in Albuquerque (PDN01); and (4) the Rio Bravo site, upstream from the Rio Bravo bridge in Albuquerque (RBR01). All piezometers were completed in the inner-valley alluvium of the Santa Fe Group aquifer system. Ground-water levels and temperatures were measured in the four piezometer nests a total of seven times in the 24-month period from September 1996 through August 1998. The flux between the surface- and ground-water systems at each of the field sites was quantified by one-dimensional numerical simulation of the water and heat exchange in the subsurface using the heat and water transport model VS2DH. Model calibration was aided by the use of PEST, a model-independent computer program that uses nonlinear parameter estimation. Mean vertical hydraulic conductivities were estimated by model calibration and range from 1.5x10-5 to 5.8x10-6 meters per second (m/s). Mean simulated vertical ground-water flux for the BRN02 piezometer nest is 3.30x10-7 m/s; for the COR01 piezometer nest is 3.58x10-7 m/s; for the PDN01 piezometer nest is 4.22x10- 7 m/s; and for the RBR01 piezometer nest is 2.05x10-7 m/s. Comparison of the simulated vertical fluxes and vertical hydraulic conductivities derived from this study with values from other studies in the Middle Rio Grande Basin indicate agreement between 1 and 3.5 orders of magnitude for hydraulic conductivity and within 1 order of magnitude for vertical flux.

Spatial and temporal distribution of the Asian fish tapeworm Bothriocephalus acheilognathi (Cestoda: Bothriocephalidea) in the Rio Grande (Río Bravo del Norte).

PubMed

Bean, Megan G; Bonner, Timothy H

2010-09-01

Recent collections of the Asian fish tapeworm Bothriocephalus acheilognathi in the Rio Grande have raised concern about the potential impacts on Rio Grande endemic and imperiled fishes. The objectives of this study were to determine distribution and definitive hosts of the Asian fish tapeworm within the Rio Grande drainage and to quantify occurrences and abundances. In total, 1,992 fish spanning 11 families were collected and examined for Asian fish tapeworms in the Rio Grande and the Pecos and Devils rivers. The parasite was collected from red shiners Cyprinella lutrensis, Tamaulipas shiners Notropis braytoni, sand shiners N. stramineus, river carpsuckers Carpiodes carpio, plains killifish Fundulus zebrinus, western mosquitofish Gambusia affinis, blue suckers Cycleptus elongatus, blacktail shiners Cyprinella venusta, proserpine shiners Cyprinella proserpina, and Manantial roundnose minnow Dionda argentosa, with the latter four species being new host records. Monthly collections of red shiners from Big Bend National Park exhibited prevalence levels above 15% in January-March and December and below 10% during April-June and October. With over 50% of the Rio Grande icthyofauna in Texas considered imperiled, the occurrence and pathological effects of the Asian fish tapeworm in combination with reduced water quantity and quality and increased habitat fragmentation are of concern for these taxa.

Host Plants of Xylosandrus mutilatus in Mississippi

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stone, W.D.; Nebeker, T.E.; Gerard, P.D.

Host range of Xylosandrus mutilatus (Blandford) in North America is reported here for the first time. Descriptive data such as number of attacks per host, size of stems at point of attacks, and height of attacks above ground are presented. Hosts observed in Mississippi were Acer rubrum L., Acer saccharum Marsh., Acer palmatum Thunb., Ostrya virginiana (Mill.) K. Koch., Cornus florida L., Fagus grandifolia Ehrh., Liquidamber styraciflua L., Carya spp., Liriodendron tulipifera L., Melia azedarach L., Pinus taeda L., Prunus serotina Ehrh., Prunus americana Marsh., Ulmus alata Michaux, and Vitus rotundifolia Michaux. Liquidamber styraciflua had significantly more successful attacks, significantlymore » higher probability of attacks, and significantly higher number of adult beetles per host tree than did Carya spp., A. rubrum, and L. tulipifera. This information is relevant in determining the impact this exotic beetle may have in nurseries, urban areas, and other forestry systems where this beetle becomes established. (author) [Spanish] El rango de hospederos de Xylosandrus mutilatus (Blandford) en America del Norte esta reportado aqui por la primera vez. Se presentan datos descriptivos como el numero de ataques por hospederos, el tamano de los tallos en el punto de ataque y la altura por encima del nivel de tierra de los ataques. Los hospederos observados en el estado de Mississippi fueron Acer rubrum L., Acer saccharum Marsh., Acer palmatum Thunb., Ostrya virginiana (Mill.) K. Koch., Cornus florida L., Fagus grandifolia Ehrh., Liquidamber styraciflua L., Carya spp., Liriodendron tulipifera L., Melia azedarach L., Pinus taeda L., Prunus serotina Ehrh., Prunus americana Marsh., Ulmus alata Michaux y Vitus rotundifolia Michaux. Liquidamber styraciflua tuvo ataques significativamente mas exitosos, una probabilidad significativamente mas alta de ataques y un numero significativamente mayor de adultos de escarabajos por arbol hospedero que Carya spp., A. rubrum y L. tulipifera. Esta informacion es pertinente en determinar el impacto que pueda tener este escarabajo exotico en invernaderos, areas urbanas y otros sistemas forestales donde el escarabajo se establece. (author)« less

Willingness to Pay for Dog Rabies Vaccine and Registration in Ilocos Norte, Philippines (2012).

PubMed

Birhane, Meseret G; Miranda, Mary Elizabeth G; Dyer, Jessie L; Blanton, Jesse D; Recuenco, Sergio

2016-03-01

The Philippines is one of the developing countries highly affected by rabies. Dog vaccination campaigns implemented through collaborative effort between the government and NGOs have played an important role in successfully reducing the burden of disease within the country. Nevertheless, rabies vaccination of the domestic animal population requires continuous commitment not only from governments and NGOs, but also from local communities that are directly affected by such efforts. To create such long-term sustained programs, the introduction of affordable dog vaccination and registration fees is essential and has been shown to be an important strategy in Bohol, Philippines. The aim of this study, therefore, was to estimate the average amount of money that individuals were willing to pay for dog vaccination and registration in Ilocos Norte, Philippines. This study also investigated some of the determinants of individuals' willingness to pay (WTP). A cross-sectional questionnaire was administered to 300 households in 17 municipalities (out of a total of 21) selected through a multi-stage cluster survey technique. At the time of the survey, Ilocos Norte had a population of approximately 568,017 and was predominantly rural. The Contingent Valuation Method was used to elicit WTP for dog rabies vaccination and registration. A 'bidding game' elicitation strategy that aims to find the maximum amount of money individuals were willing to pay was also employed. Data were collected using paper-based questionnaires. Linear regression was used to examine factors influencing participants' WTP for dog rabies vaccination and registration. On average, Ilocos Norte residents were willing to pay 69.65 Philippine Pesos (PHP) (equivalent to 1.67 USD in 2012) for dog vaccination and 29.13PHP (0.70 USD) for dog registration. Eighty-six per cent of respondents were willing to pay the stated amount to vaccinate each of their dogs, annually. This study also found that WTP was influenced by demographic and knowledge factors. Among these, we found that age, income, participants' willingness to commit to pay each year, municipality of residency, knowledge of the signs of rabies in dogs, and number of dogs owed significantly predicted WTP.

Willingness to Pay for Dog Rabies Vaccine and Registration in Ilocos Norte, Philippines (2012)

PubMed Central

Birhane, Meseret G.; Miranda, Mary Elizabeth G.; Dyer, Jessie L.; Blanton, Jesse D.; Recuenco, Sergio

2016-01-01

Background The Philippines is one of the developing countries highly affected by rabies. Dog vaccination campaigns implemented through collaborative effort between the government and NGOs have played an important role in successfully reducing the burden of disease within the country. Nevertheless, rabies vaccination of the domestic animal population requires continuous commitment not only from governments and NGOs, but also from local communities that are directly affected by such efforts. To create such long-term sustained programs, the introduction of affordable dog vaccination and registration fees is essential and has been shown to be an important strategy in Bohol, Philippines. The aim of this study, therefore, was to estimate the average amount of money that individuals were willing to pay for dog vaccination and registration in Ilocos Norte, Philippines. This study also investigated some of the determinants of individuals’ willingness to pay (WTP). Methods A cross-sectional questionnaire was administered to 300 households in 17 municipalities (out of a total of 21) selected through a multi-stage cluster survey technique. At the time of the survey, Ilocos Norte had a population of approximately 568,017 and was predominantly rural. The Contingent Valuation Method was used to elicit WTP for dog rabies vaccination and registration. A ‘bidding game’ elicitation strategy that aims to find the maximum amount of money individuals were willing to pay was also employed. Data were collected using paper-based questionnaires. Linear regression was used to examine factors influencing participants’ WTP for dog rabies vaccination and registration. Key Results On average, Ilocos Norte residents were willing to pay 69.65 Philippine Pesos (PHP) (equivalent to 1.67 USD in 2012) for dog vaccination and 29.13PHP (0.70 USD) for dog registration. Eighty-six per cent of respondents were willing to pay the stated amount to vaccinate each of their dogs, annually. This study also found that WTP was influenced by demographic and knowledge factors. Among these, we found that age, income, participants’ willingness to commit to pay each year, municipality of residency, knowledge of the signs of rabies in dogs, and number of dogs owed significantly predicted WTP. PMID:26999021

Apacheta, a new geothermal prospect in Northern Chile

DOE Office of Scientific and Technical Information (OSTI.GOV)

Urzua, Luis; Powell, Tom; Cumming, William B.

2002-05-24

The discovery of two high-temperature fumaroles, with gas geochemistry compatible with an economic geothermal system, established Apacheta as one of the most attractive geothermal exploration prospects in northern Chile. These remote fumaroles at 5,150 m elevation were first sampled in 1999 by ENAP and its partners, following up on the reports of a CODELCO water exploration well that flowed small amounts of dry steam at 4,540 m elevation in the valley 4.5 km east of the fumaroles. The prospect is associated with a Plio-Pleistocene volcanic complex located within a NW-trending graben along the axis of the high Andes. The regionalmore » water table is 4,200 masl. There are no hot springs, just the 88 degrees C steam well and the 109 degrees and 118 degrees C fumaroles with gas compositions that indicate reservoir temperatures of greater than or equal to 250 degrees C, using a variety of gas geothermometers. An MT-TDEM survey was completed in 2001-2002 by Geotermica del Norte (SDN), an ENAP-C ODELCO partnership, to explore the Apacheta geothermal concession. The survey results indicated that base of the low resistivity clay cap has a structural apex just west of the fumaroles, a pattern typically associated with shallow permeability within a high temperature geothermal resource. SGN plans to drill at least one exploration well in 2002-03 to characterize a possible economic resource at Apacheta.« less

Analysis of behavioral risk factor surveillance system data to assess the health of Hispanic Americans with diabetes in El Paso County, Texas.

PubMed

Martinez, Nelda C; Bader, Julia

2007-01-01

The purpose of this study is to determine and describe the health of Hispanic Americans who live in El Paso County, Texas, along the US-Mexico border, particularly the multidimensional self-management practices of those with diabetes. This study also assesses Hispanic Americans with diabetes consistent with Healthy People 2010 diabetes goals and objectives. Data from the 2002 Paso del Norte Behavioral Risk Factor Surveillance System are used for analysis of behavioral health risk factors associated with diabetes among Hispanic Americans in El Paso County, Texas. One- and two-way frequency tables with logistic regression and tests for comparison of means are used for data analysis. The greatest numbers of Hispanic American residents are younger, with those diagnosed with diabetes aged 45 years and older and with lower level of education, lowest income level, and unable to work. The odds of having diabetes are 4 times greater with increasing age and 6 times greater with lower income level. The type of medical treatment is consistent with the frequency of various diabetes self-management behaviors to optimize health. Hispanic Americans are within the goal for several Healthy People 2010 targets for diabetes. Hispanic Americans along the US-Mexico border remain at risk for development of diabetes, although several self-management behavioral activities are recognized as important for prevention of diabetes to optimize quality of life.

[Atypical mucocutaneous manifestations in neonates and infants with chikungunya fever in the municipalities of Cúcuta, Los Patios and Villa del Rosario, Norte de Santander, Colombia, 2014].

PubMed

Muñoz, Claudia Marcela; Castillo, José Orlando; Salas, Daniela; Valderrama, Milena Alexandra; Rangel, Claudia Teresa; Vargas, Heiddy Patricia; Silva, Diana Carolina

2016-09-01

Atypical clinical manifestations have been observed in newborns and infants suffering from fever caused by the chikungunya virus. Objective: To describe the cases of fever caused by the chikungunya virus in newborns and infants with atypical mucocutaneous lesions. Materials and methods: We reviewed the clinical records, as well as lab tests and histopathological results, of newborns and infants diagnosed with Chikungunya virus and atypical mucocutaneous lesions in three regional hospitals. Results: Out of 18 suspected cases of chikungunya virus in newborns and infants, 11 were positive and presented atypical mucocutaneous manifestations. Six of the eleven confirmed cases corresponded to children under five months of age. The most common symptoms were fever, skin rash, irritability, and diarrhea. Three of the patients were infected with both dengue and chikungunya viruses. The ulcers occurred in the scalp, abdomen, genital and perianal region. We report mucocutaneous manifestations in newborns and infants diagnosed with fever caused by the chikungunya virus in Colombia. The rapid development of ulcers is most likely due to the immune response to the virus. Special attention should be given to pregnant women presenting symptoms of chikungunya virus infection prior to delivery, and their offspring should be followed-up in order to monitor possible complications.

The origin of increased salinity in the Cambrian-Vendian aquifer system on the Kopli Peninsula, northern Estonia

NASA Astrophysics Data System (ADS)

Karro, Enn; Marandi, Andres; Vaikmäe, Rein

Monitoring of the confined Cambrian-Vendian aquifer system utilised for industrial water supply at Kopli Peninsula in Tallinn over 24 years reveals remarkable changes in chemical composition of groundwater. A relatively fast 1.5 to 3.0-fold increase in TDS and in concentrations of major ions in ed groundwater is the consequence of heavy pumping. The main sources of dissolved load in Cambrian-Vendian groundwater are the leaching of host rock and the other geochemical processes that occur in the saturated zone. Underlying crystalline basement, which comprises saline groundwater in its upper weathered and fissured portion, and which is hydraulically connected with the overlying Cambrian-Vendian aquifer system, is the second important source of ions. The fractured basement and its clayey weathering crust host the Ca-Cl type groundwater, which is characterised by high TDS values (2-20 g/L). Intensive water ion accelerates the exchange of groundwaters and increases the area of influence of pumping. Chemical and isotopic studies of groundwater indicate an increasing contribution of old brackish water from the crystalline basement and rule out the potential implication of an intrusion of seawater into aquifer. L'origine de la salinité croissante dans le système aquifère du Cambrien-Vendien dans la péninsule de Kopli, nord de l'Estonie Le suivi à long terme du système aquifère captif du Cambrien-Vendien utilisé pour l'approvisionnement d'eaux industrielles dans la Péninsule de Kopli, nord de l'Estonie, révèle de remarquables changements dans la composition chimique des eaux souterraines. Une augmentation de facteur 1.5 à 3 de la TDS et des concentrations en ions majeurs dans l'eau souterraine est la conséquence de pompages intensifs. Les sources principales des charges dissoutes dans les eaux de l'aquifère du Cambrien-Vendien sont le lessivage des roches et d'autres phénomènes géochimiques ayant lieu dans la zone saturée. Le soubassement rocheux cristallin, qui renferme des eaux souterraines salines dans sa partie supérieure altérée et fissurée, et est hydrauliquement connecté avec l'aquifère supérieur du Cambrien-Vendien, est la deuxième importante source d'ions. Le soubassement fracturé et le matériel argileux de l'altération, renferme l'eau souterraine de type Ca-Cl, caractérisée par un haut TDS (2-20 g/l). A cause de la mobilisation intensive de l'eau les échanges d'eau souterraine est sont accélérés et la zone d'influence des pompages augmentent. Les études chimiques et isotopiques indiquent une contribution croissante du drainage des eaux du soubassement cristallin. L'intrusion d'eaux salées de la mer dans le système aquifère n'est pas un phénomène évident. El origen del incremento en salinidad en un sistema de acuíferos Cámbrico-Vendiano en la Península Kopli, norte de Estonie Monitoreo a largo plazo de un sistema de acuíferos confinados, de edad Cámbrico-Vendiano, que se utiliza como fuente de abastecimiento industrial en la Península Kopli, al norte de Estonie, revela cambios notables en la composición química del agua subterránea. Un incremento de 1.5 a 3 veces en TDS y en concentraciones de iones mayores en agua subterránea explotada ha sido ocasionado por bombeo fuerte. Las fuentes principales de carga disuelta en el agua subterránea Cámbrico-Vendiano son la lixiviación de la roca encajonante y los procesos geoquímicos que ocurren en la zona saturada. Basamento cristalino subyacente, que aloja agua subterránea salada en la parte superior intemperizada y fisurada, y está conectado hidráulicamente con el sistema acuífero Cámbrico-Vendiano sobreyacente, es la segunda fuente importante de iones. El basamento fracturado y su corteza de intemperismo arcillosa alojan agua subterránea de tipo Ca-Cl la cual se caracteriza por valores altos de TDS (2-20 g/l). Debido a extracción intensiva se ha acelerado el intercambio de agua subterránea y se ha incrementado el área de influencia del bombeo. Los estudios químicos e isotópicos de agua subterránea indican una contribución creciente por filtración derivada del basamento cristalino. Es evidente una intrusión de agua salada hacia el sistema de acuíferos con implicaciones subsecuentes para la calidad del agua.

The Redwood Coast Tsunami Work Group: a unique organization promoting earthquake and tsunami resilience on California's North Coast

NASA Astrophysics Data System (ADS)

Dengler, L.; Henderson, C.; Larkin, D.; Nicolini, T.; Ozaki, V.

2012-12-01

The Northern California counties of Del Norte, Humboldt, and Mendocino account for over 30% of California's coastline and is one of the most seismically active areas of the contiguous 48 states. The region is at risk from earthquakes located on- and offshore and from tsunamis generated locally from faults associated with the Cascadia subduction zone (CSZ) and from distant sources elsewhere in the Pacific. In 1995 the California Geological Survey (CGS) published a scenario for a CSZ earthquake that included both strong ground shaking effects and a tsunami. As a result of the scenario, the Redwood Coast Tsunami Work Group (RCTWG), an organization of government agencies, tribes, service groups, academia and the private sector, was formed to coordinate and promote earthquake and tsunami hazard awareness and mitigation in the three-county region. The RCTWG and its member agencies projects include education/outreach products and programs, tsunami hazard mapping, signage and siren planning. Since 2008, RCTWG has worked with the California Emergency Management Agency (Cal EMA) in conducting tsunami warning communications tests on the North Coast. In 2007, RCTWG members helped develop and carry out the first tsunami training exercise at FEMA's Emergency Management Institute in Emmitsburg, MD. The RCTWG has facilitated numerous multi-agency, multi-discipline coordinated exercises, and RCTWG county tsunami response plans have been a model for other regions of the state and country. Eight North Coast communities have been recognized as TsunamiReady by the National Weather Service, including the first National Park the first State Park and only tribe in California to be so recognized. Over 500 tsunami hazard zone signs have been posted in the RCTWG region since 2008. Eight assessment surveys from 1993 to 2010 have tracked preparedness actions and personal awareness of earthquake and tsunami hazards in the county and additional surveys have tracked public awareness and tourist concerns about tsunami hazard signs. Over the seventeen-year period covered by the surveys, the percent with houses secured to foundations has increased from 58 to 84 percent, respondents aware of a local tsunami hazard increased from 51 to 89 percent and knowing what the Cascadia subduction zone is from 16 to 57 percent. In 2009, the RCTWG was recognized by the Western States Seismic Policy Council (WSSPC) with an award for innovation and in 2010, the RCTWG-sponsored class "Living on Shaky Ground" was awarded WSSPC's overall Award in Excellence. The RCTWG works closely with CGS and Cal EMA on a number of projects including tsunami mapping, evacuation zone planning, siren policy, tsunami safety for boaters, and public education messaging. Current projects include working with CGS to develop a "playbook" tsunami mapping product to illustrate the expected effects from a range of tsunami source events and assist local governments in focusing future response actions to reflect the range expected impacts from distant source events. Preparedness efforts paid off on March 11, 2011 when a tsunami warning was issued for the region and significant damage occurred in harbor regions of Del Norte County and Mendocino County. Full-scale evacuations were carried out in a coordinated manner and the majority of the commercial fishing fleet in Crescent City was able to exit the harbor before the tsunami arrived.

Water-quality assessment of the Rio Grande Valley, Colorado, New Mexico and Texas; fish communities at selected sites, 1993-95

USGS Publications Warehouse

Carter, L.F.

1997-01-01

Fish communities at 10 sites in the Rio Grande Basin were sampled during low-flow periods between 1993 and 1995 as part of the U.S. Geological Survey National Water-Quality Assessment Program. The ecology of fish communities is one of several lines of evidence used to characterize water-quality conditions. This report describes the fish communities at selected sites in the Rio Grande Basin and relates the structure of these fish communities to the physical and chemical characteristics of the streams. Twenty-nine species of fish representing 10 families were identified in 25 samples collected during this study. Species richness ranged from 1 to 13. Cluster analysis of the 25 samples collected during this study delineated four groups of sites that were based on the similarity of the fish communities. The first two groups were individual sites with low species richness. The third group contained the most samples, and the fourth group consisted of samples from the Rio Grande at Isleta, New Mexico, and the Rio Grande at El Paso, Texas. The shift in community structure of samples from group 3 to group 4 reflects changes from predominantly coldwater fishes to warmwater fishes. Four metrics of biotic integrity (percentages of introduced individuals, omnivores, tolerant individuals, and anomalies) were used in this study to provide a broad overview of the community structure. The relative percentages of introduced species at the Rio Grande near Del Norte, Colorado; Saguache Creek near Saguache, Colorado; Rio Grande below Taos Junction Bridge, near Taos, New Mexico; and Rio Grande at Isleta are indicative of biological stress on the communities at these sites. The dominance of omnivores in samples from the Rio Grande below Taos Junction Bridge, near Taos; Rio Chama near Chamita, New Mexico; Rio Grande at Isleta; and Rio Grande at El Paso is an indication of environmental stress at these sites. In 1995, tolerant species accounted for the entire fish community at the Rio Grande at Isleta. In all samples the occurrence of anomalies was less than 2 percent of the individuals, with the exception of the sample from the Rio Grande at Isleta. On the basis of the relative percentages of introduced individuals, omnivores, tolerant individuals, and anomalies, the biotic integrity at the Rio Grande at Isleta appears to be the most impaired of all sites and shows indications of potential chemical and physical perturbations. Fish communities from three reaches at the Santa Fe River above Cochiti Lake, New Mexico, and the Rio Grande at Isleta were sampled in 1995 to assess small-scale spatial patterns in the structure of fish communities. The spatial pattern at these sites might be associated with natural variability of the fish communities or with the presence of habitat features such as pools. The total number of individuals and relative abundance in a sample varied at sites sampled yearly during this study. All sites, with the exception of the Rio Grande near Del Norte, had a decline in total number of individuals in a sample. The temporal decline in the total number of individuals at these site might be associated with the natural variability within the fish communities.

Algunos Resumenes

NASA Astrophysics Data System (ADS)

1980-12-01

EI "Palomar Observatory Sky Survey" es un medio auxiliar bien conocido y ütil para los astronomos. Todo el cielo dei hemisferio Norte esta captado en lotografias, cuyas reproducciones se encuentran archivadas en las bibliotecas de casi todos los observatorios importantes dei mundo.

Incorporating weather impacts in traffic estimation and prediction systems (TREPS)

DOT National Transportation Integrated Search

2009-09-01

This document provides quantitative benefits of using Intelligent Transportation Systems in highway construction and maintenance work zones. The technical report covers case study sites in the District of Columbia, Texas, Michigan, Arkansas, and Nort...

[Fragments of history in psychiatric care Rio Grande do Norte, Brazil].

PubMed

de Miranda, Francisco Arnoldo Nunes; Santos, Raionara Cristina de Araújo; de Azevedo, Dulcian Medeiros; Fernandes, Rafaella Leite; Costa, Tarciana Sampaio

2010-09-01

This article aims to rescue aspects of the performing therapeutic of the Day Hospital (HD) Dr Elger Nunes, Natal, Rio Grande do Norte, Brazil, during its term, and analyze the results regarding to the number of patients assisted from 1996 to 2004. This is an empirical, descriptive and exploratory study, ex post facto with a quantitative approach, carried out through the analysis of the records of 910 people attended in the hospital. The data was submitted to the informational resource software Microsoft Excel and converted into diagrams. The results show a greater accessibility to this treatment modality, decreasing in hospitalization-time length and improving hospital discharge conditions for users, with reduction in number of patients who interrupted treatment. It focus on the importance of the Day Hospital in the process of psychiatric reform, with care grounded on the use of the humanized therapeutic practices, and still not losing the bond with family and society.

Evidence for maize (Zea mays) in the Late Archaic (3000–1800 B.C.) in the Norte Chico region of Peru

PubMed Central

Haas, Jonathan; Creamer, Winifred; Huamán Mesía, Luis; Goldstein, David; Reinhard, Karl; Rodríguez, Cindy Vergel

2013-01-01

For more than 40 y, there has been an active discussion over the presence and economic importance of maize (Zea mays) during the Late Archaic period (3000–1800 B.C.) in ancient Peru. The evidence for Late Archaic maize has been limited, leading to the interpretation that it was present but used primarily for ceremonial purposes. Archaeological testing at a number of sites in the Norte Chico region of the north central coast provides a broad range of empirical data on the production, processing, and consumption of maize. New data drawn from coprolites, pollen records, and stone tool residues, combined with 126 radiocarbon dates, demonstrate that maize was widely grown, intensively processed, and constituted a primary component of the diet throughout the period from 3000 to 1800 B.C. PMID:23440194

Gastrointestinal parasites of sheep, municipality of Lajes, Rio Grande do Norte, Brazil.

PubMed

de Souza, Maria de Fátima; Pimentel-Neto, Manoel; da Silva, Rízia Maria; Farias, Albeísa Cleyse Batista; Guimarães, Marcos Pezzi

2012-01-01

This study investigated the gastrointestinal parasitism by helminths and protozoa in sheep (Ovis aries) Santa Inês breed, municipality of Lajes, Rio Grande do Norte. Monthly, from April 2005 to August 2007, stool samples were collected from two tracer lambs in the first day of the experiment and performed a necropsy of these animals in 44th day. A total of 64 lambs were sampled, but only 62 lambs were slaughtered. The fecal samples were examined by sedimentation in water. The contents of the abomasum, small intestine and large intestine were examined for the recovery of helminths. The parasitological examination revealed eggs of the following groups of helminths: Strongyloidea, Strongyloides sp., Trichuris sp., and Moniezia sp. Also were found oocysts of Eimeria spp., cysts of Entamoeba ovis and Giardia duodenalis. The helminths identified from examining the contents were: Haemonchus contortus, Cooperia pectinata, Cooperia punctata, Trichostrongylus colubriformis, Moniezia expansa, Oesophagostomum sp. Skrjabinema ovis and Trichuris sp.

The Geological Trace Of The 1932 Tsunamis In The Tropical Jalisco-Colima Coast, Mexico

NASA Astrophysics Data System (ADS)

Ramirez-Herrera, M.; Blecher, L.; Goff, J. R.; Corona, N.; Chague-Goff, C.; Lagos, M.; Hutchinson, I.; Aguilar, B.; Goguitchaichrili, A.; Machain-Castillo, M. L.; Rangel, V.; Zawadzki, A.; Jacobsen, G.

2013-05-01

The study and preservation of tsunami deposits have being challenging in humid tropical environments. While tsunami deposits have been widely studied at temperate latitudes, few studies assess this problem in tropical environments due to the difficulties intrinsic to these places (e.g. tsunami deposit preservation, post-burial changes in a tropical environment, mangrove vegetation, difficult access, wildlife, among others). Here we assess the problem of tsunami-deposits preservation on the Jalisco-Colima tropical coast of Mexico, which parallels the more than 1000-km long Mexican subduction, where historical accounts indicate the occurrence of two significant tsunamis on June 3 and 22, 1932 (Corona and Ramírez-Herrera, 2012a, Valdivia et al., 2012). However, up to date, no geological evidence of these events has been reported. We present geological evidence of two large tsunamis related to the June 3, M 8.2 earthquake, and the June 22, Ms 6.9 landslide-triggering event of 1932 (Corona and Ramírez-Herrera, 2012a, b). A multiproxy approach was applied to unravel the nature of anomalous sand units and sharp basal contacts in the stratigraphy of a number of sites at Palo Verde estuary, El Tecuán swales and marsh, and La Manzanilla swales, on the Jalisco-Colima coast. Lines of evidence including historical, geomorphological, stratigraphic, grain size, organic matter content, microfossils (diatoms and foraminifera), geochemical content, magnetic susceptibility and AMS analyses, together with dating (210Pb and 14C), and modeling, corroborate the presence of tsunami deposits of both the 3 June 1932 tsunami at El Tecuán and La Manzanilla, and the 22 June 1932 tsunami at Palo Verde. Further evidence of earlier tsunamis, at least four events, is also evident in the stratigraphy. Work in progress should reveal the chronology of the earliest tsunamis and their origin. Corona, N., M.T. Ramirez-Herrera. (2012a) Mapping and historical reconstruction of the great Mexican 1932 tsunami. Natural Hazards and Earth System Sciences, 12, 1337-1352. NHESS-2011-369. Corona Morales N. y M.T. Ramírez-Herrera. (2012b) Técnicas histórico-etnográficas en la reconstrucción y caracterización de tsunamis: El ejemplo del gran tsunami del 22 de junio de 1932, en las costas del Pacífico Mexicano. Revista de Geografía Norte Grande. 53, 107-122. Valdivia O. L., Castillo A. M.R., Estrada T. M. (2012). Tsunamis en Jalisco, Geocalli, Cuadernos De Geografía, Universidad de Guadalajara. Año 13, No. 25, 103p.

Diversity, origin and tectonic significance of the Mesoarchean granitoids of Ourilândia do Norte, Carajás province (Brazil)

NASA Astrophysics Data System (ADS)

da Silva, Luciano Ribeiro; de Oliveira, Davis Carvalho; dos Santos, Maria Nattânia Sampaio

2018-03-01

This study investigates the diversity, origin and tectonic significance of the Ourilândia do Norte Mesoarchean granitoids, emplaced near Rio Maria-Carajás domains boundary, southeastern Amazonian Craton (Brazil). In this area, previous works has identified sanukitoids (∼2.87 Ga), (quartz) diorites of BADR affinity and undifferentiated leucogranites, with charnockites cross-cutting the other granitoids. New geological mapping data allowed to differentiate three new groups of granitoids: (i) biotite monzogranites (BMzG); (ii) epidote-biotite granodiorites (EBGd); and (iii) porphyritic granitoids (pGrt). Thus, this paper aims to define their classification, nature, formation processes and deformation aspects, and discuss the relations between plutonism and deformation for the Ourilandia do Norte granitoids. The petrographic data showed that each one of these groups can be subdivided into two facies. The BMzG is differentiated into equigranular (eBMzG) and heterogranular (hBMzG) and the EBGd into heterogranular (hEBGd) and sparsely porphyritic (spTEBGd). These granitoids constitute two batholiths separated by a rock strip of sanukitoid and BADR affinities. Both are largely dominated by BMzG rocks, with less abundant EBGd lenses. The pGrt is individualized in porphyritic granodiorites (pBHGd) and trondhjemites (pEBTd), which occur as smaller bodies. Structurally, the central portions these plutons represent lower strain domains, while their borders are marked by large-scale shear zones, where occur submagmatic and mylonitic fabrics of ENE-WSW main direction and subvertical dip, respectively. The meso- and microstructural data indicate that the rocks studied are syn-to late-tectonic and were affected by high temperature deformation (>500 °C) and low differential stress, in a sinistral transpression regime, indicating that both fabrics are related to the a same deformational event. Geochemically, except the pEBTd facies that has sodic affinity, the Ourilândia do Norte granitoids can be grouped into two suites: (i) Fe-K suite formed by BMzG and spTEBGd; and (ii) Mg-K suite composed of sanukitoids (including hEBGd and pBHGd) and (quartz) diorites of BADR affinity. The origin of the eBMzG is attributed to anatexis of a 2.92-2.98 Ga old TTG crust. The hEBGd has sanukitoid affinity and was produced by intense fractionation of hornblende ± clinopyroxene from the Rio Maria Granodiorite. The granitoids of spTEBGd, hBMzG, pBHGd and pEBTd facies show mingling evidence between contrasting magmas, indicating that their origins require interaction between metassomatized mantle- and crustal derived magmas. Geochemical data and modeling were used to identify their different formation processes: (i) spTEBGd is enriched in HFSE (Ti, Zr and Y) and LILE (Ba and Sr) and it was interpreted as product of the partial melting of an enriched mantle source, with participation of crustal liquids; (ii) hBMzG is generated by the interaction between spTEBGd (60%) and eBMzG (40%) magmas; (iii) pBHGd by hybridization between sanukitoid (80%) and eBMzG (20%); and (iv) pEBTd by mixture between trondhjemitic (70-80%) and BARD-affinity (20-30%) liquids. Therefore, at ∼2.87-2.86 Ga a significant crustal growth and reworking occurred in the final stages of stabilization of the first geotectonic cycle of Carajás province, where all the Ourilândia do Norte Mesoarchean granitoids were emplacement during the second stage of a tectono-magmatic two-stage (subduction-collision) model: (i) first stage (2.98-2.92 Ga) - low-angle subduction with emplacement of slab-melt and mantle wedge metasomatism; (ii) second stage (∼2.87-2.86 Ga) - collisional environment, where shear zones conditioned the rise and emplacement of the Ourilândia do Norte magmas.

Journal of Transportation and Statistics : special issue on the Northridge earthquake

DOT National Transportation Integrated Search

1998-09-01

This is special issue on the Northridge Earthquake. Contents: Impacts of the Northridge Earthquake on Transit and Highway Use by Genevieve Giuliano; Transport Related Impacts on the Northridge Earthquake by Peter Gordon; Goods Movement After the Nort...

Impact of payments for environmental services and protected areas on local livelihoods and forest conservation in northern Cambodia

PubMed Central

Clements, Tom; Milner-Gulland, E J

2015-01-01

The potential impacts of payments for environmental services (PES) and protected areas (PAs) on environmental outcomes and local livelihoods in developing countries are contentious and have been widely debated. The available evidence is sparse, with few rigorous evaluations of the environmental and social impacts of PAs and particularly of PES. We measured the impacts on forests and human well-being of three different PES programs instituted within two PAs in northern Cambodia, using a panel of intervention villages and matched controls. Both PES and PAs delivered additional environmental outcomes relative to the counterfactual: reducing deforestation rates significantly relative to controls. PAs increased security of access to land and forest resources for local households, benefiting forest resource users but restricting households’ ability to expand and diversify their agriculture. The impacts of PES on household well-being were related to the magnitude of the payments provided. The two higher paying market-linked PES programs had significant positive impacts, whereas a lower paying program that targeted biodiversity protection had no detectable effect on livelihoods, despite its positive environmental outcomes. Households that signed up for the higher paying PES programs, however, typically needed more capital assets; hence, they were less poor and more food secure than other villagers. Therefore, whereas the impacts of PAs on household well-being were limited overall and varied between livelihood strategies, the PES programs had significant positive impacts on livelihoods for those that could afford to participate. Our results are consistent with theories that PES, when designed appropriately, can be a powerful new tool for delivering conservation goals whilst benefiting local people. El Impacto de los Pagos por Servicios Ambientales y Áreas Protegidas sobre la Subsistencia Local y la Conservación del Bosque en el Norte de Camboya Resumen Los impactos potenciales de los pagos por servicios ambientales (PSA) y áreas protegidas (APs) sobre los resultados ambientales y las subsistencias locales en los países en desarrollo son polémicos y se han debatido ampliamente. La evidencia disponible es escasa; ha habido pocas evaluaciones rigurosas de los impactos ambientales y sociales de las APs y particularmente los PSA. Medimos el impacto sobre los bosques y el bienestar humano en tres diferentes programas de PSA que se llevan a cabo dentro de dos APs en el norte de Camboya usando un panel de aldeas de intervención y controles emparejados. Tanto los PSA como las APs brindaron resultados ambientales adicionales en relación a los contrafácticos, esto quiere decir que redujeron las tasas de deforestación significativamente en relación a los controles. Las áreas protegidas incrementaron el acceso seguro a los recursos del suelo y el bosque para las viviendas locales, beneficiando a los usuarios de los recursos del bosque pero restringiendo la habilidad de las viviendas para expandirse y diversificar su agricultura. Los impactos de los pagos por servicios ambientales sobre el bienestar de las viviendas estuvieron relacionados con la magnitud de los pagos proporcionados. Los dos programas de PSA de mayor paga y con conexión al mercado tuvieron impactos positivos significativos, mientras que un programa de menor paga con el objetivo de proteger a la biodiversidad no tuvo un efecto detectable sobre las viviendas, a pesar de sus resultados ambientales positivos. Las viviendas que se inscribieron a los programas de PSA con mayor paga, sin embargo, necesitaban típicamente más bienes capitales, por lo que eran menos pobres y tenían mayor seguridad alimentaria que otros aldeanos. Por esto, mientras los impactos de las APs sobre el bienestar de las viviendas fueron limitados en general y variaron dependiendo de las estrategias de subsistencia, los programas de PSA tuvieron impactos positivos significativos sobre las viviendas para aquellos que podían costear participar. Nuestros resultados son congruentes con las teorías de que los PSA, cuando se designan apropiadamente, pueden ser una herramienta poderosa y novedosa para obtener objetivos de conservación mientras se beneficia a la gente local. PMID:25492724

Seismic-reflection and sidescan-sonar data collected off eastern Cape Cod, Massachusetts, during April 1979

USGS Publications Warehouse

Knebel, Harley J.

1981-01-01

The U.S. Geological Survey collected 98 line kilometers of single-channel seismic-reflection profiles and sidescan sonar records on the inner shelf of eastern Cape Cod, Massachusetts, during April 1979. The data were obtained during cruise NE-1-79 of the R/V NEECHO. The purposes of the survey were: (1) to study the development of barrier islands; (2) to document the frequency and rate of migration of inlets that breach barrier islands; and (3) to define the characteristics of shoreface ridges on a barrier island.he survey uti I ized two acoustic systems. Information about the bottom was obtained by using an EDO Western model 606 sidescan-sonar system (100 kHz). Profiles of the subbottom were collected by an EG&G Uni boom transducer (400-4,000 Hz) and a Del Norte streamer. Positional control for al I track! ines was provided by a shore-based Miniranger system and by LORAN-C.The quality of the records generally is very good. However, subbottom penetration did vary somewhat from place to place during the survey due to the nature of the bottom sediments and to the presence or absence of buried channels.The original records may be examined at the U.S. Geological Survey, Woods Hole, MA 02543. Microfilm copies of the data are avai I able for purchase from the National Geophysical pnd Solar-Terrestrial Data Center, NOAA/EDIS/NGSDC, Code D621, 325 Broadway, Boulder, CO 80303 (303-497-6338).

Evaluation of continuity detail for precast prestressed girders : research project capsule.

DOT National Transportation Integrated Search

2008-03-01

The construction of a new bridge : crossing the Mississippi River north of : Baton Rouge is currently underway. The : project, named the John James : Audubon Bridge, is a true landmark. Its : main span will be the longest cablestayed : bridge in Nort...

Estimating pothole wetland connectivity to Pipestem Creek, North Dakota: an isotopic approach

EPA Science Inventory

Understanding hydrologic connectivity between wetlands and perennial streams is critical to understanding how reliant stream flow is on wetlands within their watershed. We used the isotopic evaporation signal in water to examine hydrologic connectivity within Pipestem Creek, Nort...

DRINKING WATER ISSUES

EPA Science Inventory

According to recent reports by the California Department of Health Services, the State of Maine, and the United State Geological Survey (USGS); the fuel oxygenate methyl teri-butyl ether (MTBE) is present in 5 to 20 percent of the drinking water sources in California and the nort...

The effect of adjuvant radiation on survival in early stage clear cell ovarian carcinoma.

PubMed

Hogen, Liat; Thomas, Gillian; Bernardini, Marcus; Bassiouny, Dina; Brar, Harinder; Gien, Lilian T; Rosen, Barry; Le, Lisa; Vicus, Danielle

2016-11-01

To assess the impact of adjuvant radiotherapy (RT) on survival in patients with stage I and II ovarian clear cell carcinoma (OCCC). Data collection and analysis of stage I and II OCCC patients treated at two tertiary centers in Toronto, between 1995 and 2014, was performed. Descriptive statistics and Kaplan-Meier survival probability estimates were completed. The log-rank test was used to compare survival curves. 163 patients were eligible. 44 (27%) patients were treated with adjuvant RT: 37 of them received adjuvant chemotherapy (CT), and 7 had RT only. In the no-RT group, there were 119 patients: 83 patients received adjuvant CT and 36 had no adjuvant treatment. The 10year progression free survival (PFS) was 65% for patients treated with RT, and 59% no-RT patients. There were a total of 41 (25%) recurrences in the cohort: 12 (27.2%) patients in RT group and 29 (24.3%) in the no-RT group. On multivariable analysis, adjuvant RT was not significantly associated with an increased PFS (0.85 (0.44-1.63) p=0.63) or overall survival (OS) (0.84 (0.39-1.82) p=0.66). In the subset of 59 patients defined as high-risk: stage IC with positive cytology and/or surface involvement and stage II: RT was not found to be associated with a better PFS (HR 1.18 (95% CI: 0.55-2.54) or O S(HR 1.04 (95% CI: 0.40-2.69)). Adjuvant RT was not found to be associated with a survival benefit in patients with stage I and II ovarian clear cell carcinoma or in a high risk subset of patients including stage IC cytology positive/surface involvement and stage II patients. Copyright © 2016 Elsevier Inc. All rights reserved.

RAPID ASSESSMENT OF URBAN WETLANDS: FUNCTIONAL ASSESSMENT MODEL DEVELOPMENT AND EVALUATION

EPA Science Inventory

The objective of this study was to test the ability of existing hydrogeomorphic (HGM) functional assessment models and our own proposed models to predict rates of nitrate production and removal, functions critical to water quality protection, in forested riparian wetlands in nort...

On the occurrence of Cebus flavius (Schreber 1774) in the Caatinga, and the use of semi-arid environments by Cebus species in the Brazilian state of Rio Grande do Norte.

PubMed

Ferreira, Renata G; Jerusalinsky, Leandro; Silva, Thiago César Farias; de Souza Fialho, Marcos; de Araújo Roque, Alan; Fernandes, Adalberto; Arruda, Fátima

2009-10-01

Cebus flavius is a recently rediscovered species and a candidate for the 25 most endangered primate species list. It was hypothesized that the distribution of C. flavius was limited to the Atlantic Forest, while the occurrence of C. libidinosus in the Rio Grande do Norte (RN) Caatinga was inferred, given its occurrence in neighboring states. As a result of a survey in ten areas of the RN Caatinga, this paper reports on four Cebus populations, including the first occurrence of C. flavius in the Caatinga, and an expansion of the northwestern limits of distribution for the species. This C. flavius population may be a rare example of a process of geographic distribution retraction, and is probably the most endangered population of this species. New areas of occurrence of C. libidinosus are also described. Tool use sites were observed in association with reports of the presence of both capuchin species.

Dating the Late Archaic occupation of the Norte Chico region in Peru.

PubMed

Haas, Jonathan; Creamer, Winifred; Ruiz, Alvaro

2004-12-23

The Norte Chico region on the coast of Peru north of Lima consists of four adjacent river valleys--Huaura, Supe, Pativilca and Fortaleza--in which archaeologists have been aware of a number of apparently early sites for more than 40 years (refs 1- 3). To clarify the early chronology in this region, we undertook fieldwork in 2002 and 2003 to determine the dates of occupation of sites in the Fortaleza and Pativilca valleys. Here we present 95 new radiocarbon dates from a sample of 13 of more than 20 large, early sites. These sites share certain basic characteristics, including large-scale monumental architecture, extensive residential architecture and a lack of ceramics. The 95 new dates confirm the emergence and development of a major cultural complex in this region during the Late Archaic period between 3000 and 1800 calibrated calendar years bc. The results help to redefine a broader understanding of the respective roles of agricultural and fishing economies in the beginnings of civilization in South America.

Utilization of LANDSAT orbital imagery in the soil survey processes at Rio Grande do Norte state

NASA Technical Reports Server (NTRS)

Formaggio, A. R. (Principal Investigator)

1984-01-01

Pedologic photointerpretative criteria adapted to LANDSAT orbital imagery were used: drainage (pattern, integration degree, density and uniformity degree); relief (pattern, dissection degree and crest lines); photographic texture, photographic tonnality, and the land use (type, glebas size and intensity of use). The performance of the imagery as an auxiliar tool in the soil survey processes, at Rio Grande do Norte State was evaluated. The drainage and relief elements were easily extracted from the imagery and also ones that provided the greatest deductive possibility about pedologic boundaries. Other analyzed criteria were considered only auxiliaries, corroborating some soil limits in the evidences convergence phase. The principal pedologic dominions of the 30,000 sq km are covered by the same LANDSAT image (WRS 359/16) were delimited with good precision: (1) fluvial plains, beaches, dunes and coastal mangroves; (2) North Coast line Plateau; (3) Acu Sandstone Zone; (4) residual plateaus of the Tertiary; and (6) plains of the embasement.

Language as Cultural Practice: Mexicanos en el Norte.

ERIC Educational Resources Information Center

Schecter, Sandra R.; Bayley, Robert

This book offers an ethnographic account of language socialization practices within Mexican-background families residing in California and Texas. It illustrates cases where language is used by speakers to choose between alternative self-definitions and where language interacts differentially with other defining categories (ethnicity, gender, and…

Hydrologic and Water Quality Assessment from Managed Turf

USDA-ARS?s Scientific Manuscript database

The potential for nutrients and pesticides to be transported to surface water from turf systems (especially golf courses) is often debated because of limited information on water quality exiting these systems. This four year study quantified the amount and quality of water draining from part of Nort...

The Role of Sex and Mating Status in the Expansion Process of Arhopalus rusticus (Coleoptera: Cerambycidae)-an Exotic Cerambycid in Argentina.

PubMed

Grilli, Mariano Pablo; Fachinetti, Romina

2017-06-01

In Córdoba province, central Argentina, there is an area of introduced pine trees, in which an invading Cerambycid, Arhopalus rusticus (L.), was detected in this region for the first time in 2006. The species has since expanded its range until it now occupies the whole area. Arhopalus rusticus is a common species in pine forests of the northern hemisphere. In this paper, we analyze how sex and mating status affects flight performance and the potential distribution of this species. The study was performed with individuals collected from introduced pine forests in the center-west of Córdoba Province (Argentina). The dispersal capability of A. rusticus was determined by measuring flight speed and distance traveled by recently emerged mated and unmated A. rusticus in flight mills. Data of preflight body weight, postflight body weight, body length, and elytron size were obtained from the individuals that were flown in the flight mill. We found that females had a greater body length, weighed more, had longer elytra, and were stronger flyers than males. We also found that mated individuals flew faster and longer distances than unmated individuals, and consumed a smaller fraction of their body weight. A positive ratio was observed between elytra size and flight speed. A map of males' and females' dispersal distances was produced for the study region, using the adjusted dispersal distance distribution of males and females. The flight performance showed that, as females disperse after copulation, they increase the chances of establishing the species in unoccupied areas.En la provincia de Córdoba, Argentina, hay una importante área de pinos implantados. En esta región durante el año 2006 se detectó por primera vez a Arhopalus rusticus (L.), un Cerambycidae invasor. A. rusticus es una especie común en los bosques de pino del hemisferio norte. En este trabajo analizamos de qué manera el sexo y el estado de apareamiento afectan el desempeño de vuelo y la distribución potencial de esta especie. Utilizamos individuos recolectados de los bosques de pino implantados en la región centro oeste de la provincia de Córdoba (Argentina). La capacidad de dispersión de Arhopalus rusticus se determinó haciendo volar individuos recién emergidos en un molino de vuelo. Se registró el peso previo y posterior al vuelo, el largo del cuerpo y el tamaño del élitro. Las hembras fueron mejores voladoras, más largas, más pesadas, con élitros más largos que los machos. Observamos diferencias entre el potencial de dispersión dependiendo del estado de apareamiento de los individuos. Los individuos apareados volaron más rápido y mayores distancias que los individuos no apareados y consumieron una menor fracción de su peso corporal. Se observó una relación positiva entre el tamaño del élitro y la velocidad de vuelo. Se generó un mapa de las distancias de dispersión potencial de los machos y de las hembras para la región de estudio utilizando las distribuciones de las distancias obtenidas del molino de vuelo. La dispersión post copulación incrementa las chances de que la especie se establezca en zonas no ocupadas. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Biology and population dynamics of the cactus moth, Cactoblastis cactorum

USDA-ARS?s Scientific Manuscript database

The cactus moth, Cactoblastis cactorum, was a successful biological control agent against prickly pear cacti in Australia in the 1920’s. Since then, it was introduced to other countries including the Carribean islands. In 1989, the cactus moth was reported in Florida and has continued to spread nort...

[In Process Citation].

PubMed

Cuerda, Cristina; Álvarez, Julia; Ramos, Primitivo; Abánades, Juan Carlos; García-de-Lorenzo, Abelardo; Gil, Pedro; De-la-Cruz, Juan José

2016-03-25

Introducción: la desnutrición relacionada con la enfermedad (DRE) es un problema sociosanitario frecuente que afecta preferentemente a los mayores de 65 años, que aumenta la morbimortalidad y disminuye la calidad de vida.  Objetivo: estudiar la prevalencia de DRE en mayores de 65 años en diferentes centros sociosanitarios del Servicio Regional de Bienestar Social de la Comunidad de Madrid. Métodos: estudio transversal en 33 centros sociosanitarios de Madrid (6 centros de atención primaria [AP], 9 centros de mayores [CM], 9 hospitales [H] y 9 residencias [R]) seleccionados mediante muestreo polietápico. Las variables estudiadas fueron edad, sexo, nivel de dependencia según la escala de incapacidad de la Cruz Roja, motivo de ingreso y enfermedad de base, hábitat (urbano-periurbano-rural) y distribución geográfica (norte centro-sur). Como herramienta de cribado nutricional se utilizó el Mini Nutritional Assessment (MNA-cribaje) en todos los centros. En los pacientes con cribado positivo (en riesgo-desnutrición) se realizó el MNA-evaluación. El estudio estadístico se realizó con el paquete SSS 21.0 e incluyó estadística descriptiva, test de Chi-cuadrado y prueba exacta de Fisher, ANOVA de un factor, Kruskal-Wallis y análisis de regresión logística (RL) binaria univariante y multivariante. Se consideró significación estadística p < 0,05. Resultados: se reclutaron 1.103 sujetos (275 AP, 278 CM, 281 H, 269 R), edad media de 79,5 ± 8,4 años (41,2% varones, 58,8% mujeres). Los sujetos procedentes de H y R tuvieron un mayor grado de incapacidad (p < 0,001). La prevalencia global de DRE fue del 10%, encontrándose un 23,3% en riesgo de desnutrición, con diferencias entre los cuatro tipos de centros sociosanitarios (p < 0,001). El análisis univariante de RL mostró diferencia significativas en la prevalencia de desnutrición según la edad, sexo, grado de dependencia, tipo de centro sociosanitario, hábitat y zona geográfica. Sin embargo, en el análisis multivariante solo el grado de dependencia, el tipo de centro y el hábitat tuvieron significación estadística. Conclusiones: la prevalencia de DRE en mayores de 65 años en la Comunidad de Madrid es del 10%, encontrándose además un 23,3% en riesgo de desnutrición. Las únicas variables que se relacionaron de forma independiente con la desnutrición en el análisis multivariante fueron el nivel de dependencia de los pacientes y el tipo y hábitat de centro sociosanitario.

A new species of big-eared climbing rat, genus Ototylomys (Cricetidae: Tylomyinae), from Chiapas, Mexico

PubMed Central

Porter, Calvin A; Beasley, Nia E; Ordóñez-Garza, Nicté; Lindsey, Laramie L; Rogers, Duke S; Lewis-Rogers, Nicole; Sites, Jack W; Bradley, Robert D

2017-01-01

Abstract An allopatric population of big-eared climbing rats (Ototylomys) from the Northern Highlands of Chiapas, Mexico, is described as a new species. The new taxon is part of a unique montane rainforest community that includes several other endemic species in the limited geographic range between the Río Grijalva and the Central Depression of Chiapas. Several cranial, external, and molecular characters distinguish this new species of big-eared climbing rat from its more widely distributed congener, Ototylomys phyllotis. We performed principal component and discriminate function analyses of cranial measurements, and found that specimens of the new species consistently could be distinguished from other Ototylomys with strong statistical support. Compared with exemplars of Ototylomys from elsewhere in their range, the new species possesses a karyotype that differs by 3 additional biarmed chromosome pairs, is fixed or nearly fixed for distinct electromorphs at 12 allozyme loci, and the mean genetic distance exceeds 14%, based on comparisons of the mitochondrial cytochrome b gene between the new species of Ototylomys and representatives of O. phyllotis. The restricted distribution in montane karst rainforest suggests that the species and its habitat may be a matter of conservation concern. Una población alopátrica de rata orejuda trepadora (Ototylomys) de las Tierras Altas del Norte de Chiapas, México se describe como una nueva especie. El nuevo taxón es parte de una comunidad única de bosque lluvioso montano que incluye varias especies endémicas en el área de distribución geográfica limitada entre el Río Grijalva y la Depresión Central de Chiapas. Varios caracteres craneales, externos, y moleculares distinguen la nueva rata orejuda trepadora de su congénere más ampliamente distribuido, Ototylomys phyllotis. Se realizaron análisis de componentes principales y de función discriminante de los caracteres craneales, y se encontró que los especímenes de La Pera fueron consistentemente distinguidos de otros Ototylomys con un fuerte soporte estadístico. En comparación con ejemplares de Ototylomys del rango, la nueva especie posee un cariotipo que difiere por 3 pares adicionales de cromosomas biarmados, está fijo o casi fijo por distintos electromorfos en 12 loci alozímicos. Adicionalmente, la media de la distancia genética comparada del gen mitochondrial citocromo b entre la nueva especie de Ototylomys y representantes de O. phyllotis, excede el 14%. La distribución restringida en el bosque lluvioso montano kárstico sugiere que la especie y su hábitat pueden ser de importancia para la conservación. PMID:29674786

A new species of big-eared climbing rat, genus Ototylomys (Cricetidae: Tylomyinae), from Chiapas, Mexico.

PubMed

Porter, Calvin A; Beasley, Nia E; Ordóñez-Garza, Nicté; Lindsey, Laramie L; Rogers, Duke S; Lewis-Rogers, Nicole; Sites, Jack W; Bradley, Robert D

2017-10-03

An allopatric population of big-eared climbing rats ( Ototylomys ) from the Northern Highlands of Chiapas, Mexico, is described as a new species. The new taxon is part of a unique montane rainforest community that includes several other endemic species in the limited geographic range between the Río Grijalva and the Central Depression of Chiapas. Several cranial, external, and molecular characters distinguish this new species of big-eared climbing rat from its more widely distributed congener, Ototylomys phyllotis . We performed principal component and discriminate function analyses of cranial measurements, and found that specimens of the new species consistently could be distinguished from other Ototylomys with strong statistical support. Compared with exemplars of Ototylomys from elsewhere in their range, the new species possesses a karyotype that differs by 3 additional biarmed chromosome pairs, is fixed or nearly fixed for distinct electromorphs at 12 allozyme loci, and the mean genetic distance exceeds 14%, based on comparisons of the mitochondrial cytochrome b gene between the new species of Ototylomys and representatives of O. phyllotis . The restricted distribution in montane karst rainforest suggests that the species and its habitat may be a matter of conservation concern. Una población alopátrica de rata orejuda trepadora ( Ototylomys ) de las Tierras Altas del Norte de Chiapas, México se describe como una nueva especie. El nuevo taxón es parte de una comunidad única de bosque lluvioso montano que incluye varias especies endémicas en el área de distribución geográfica limitada entre el Río Grijalva y la Depresión Central de Chiapas. Varios caracteres craneales, externos, y moleculares distinguen la nueva rata orejuda trepadora de su congénere más ampliamente distribuido, Ototylomys phyllotis . Se realizaron análisis de componentes principales y de función discriminante de los caracteres craneales, y se encontró que los especímenes de La Pera fueron consistentemente distinguidos de otros Ototylomys con un fuerte soporte estadístico. En comparación con ejemplares de Ototylomys del rango, la nueva especie posee un cariotipo que difiere por 3 pares adicionales de cromosomas biarmados, está fijo o casi fijo por distintos electromorfos en 12 loci alozímicos. Adicionalmente, la media de la distancia genética comparada del gen mitochondrial citocromo b entre la nueva especie de Ototylomys y representantes de O. phyllotis , excede el 14%. La distribución restringida en el bosque lluvioso montano kárstico sugiere que la especie y su hábitat pueden ser de importancia para la conservación.

Structural setting of the Metán Basin (NW Argentina): new insights from 2D seismic profiles

NASA Astrophysics Data System (ADS)

Conti, Alessia; Maffucci, Roberta; Bigi, Sabina; Corrado, Sveva; Giordano, Guido; Viramonte, José G.

2017-04-01

The Metán Basin is located in the sub-Andean foreland, in the southernmost portion of the Santa Barbara system structural province (NW Argentina). The upper crust in this region shows a strong segmentation due to inherited stratigraphic and structural discontinuities, related to a Palaeozoic orogenic event and to a Cretaceous to Paleogene rifting event (Kley et al., 1999; Iaffa et al., 2011). This study seeks to unravel the deep structural setting of the basin, in order to better understand the tectonic evolution of the area. Different seismic sections are analysed, located in the Metán basin and acquired by YPF (Yacimientos Petrolíferos Fiscales, former national oil company of Argentina) in different surveys during the '70s - '80s. Stratigraphic control for the seismic interpretation is provided by petroleum exploratory wells drilled in the basin; they show a stratigraphic succession of syn-rift and post-rift deposits, mainly constituted by a continental succession of red beds, with minor limestone intercalations (Salta Group), overlain by a thick continental foreland basin succession (Orán Group) (Salfity et al., 1981). From a structural point of view, the Metán basin is characterized by a variety of structural trends, with thrust faults and related folds mainly trending N-S, NE-SW and NNE-SSW. Different mechanism can be responsible for the folding of the sedimentary cover; hangingwall anticlines are represented both by high angle thrust faults produced by inversion of Cretaceous extensional faults (Maffucci et al., 2015), and by fault propagation folds formed during the Andean shortening event. The study of the interaction between the older reactivated faults and the newly generated ones could provide new insights to unravel the complex structural setting of the area. References Iaffa D. N., Sàbat, F., Muñoz, J.A., Mon, R., Gutierrez, A.A., 2011. The role of inherited structures in a foreland basin evolution. The Metán Basin in NW Argentina. Journal of Structural Geology, 33, 1816-1828. Kley, J., Monaldi, C. R. & Salfity, J. A., 1999. Along strike segmentation of the Andean foreland: causes and consequences. Tectonophysics, 301, 75-94. Maffucci, R., Bigi, S., Corrado, S., Chiodi, A., Di Paolo, L., Giordano, G., Invernizzi, C., 2015. Quality assessment of reservoirs by means of outcrop data and "discrete fracture network" models: The case history of Rosario de La Frontera (NW Argentina) geothermal system. Tectonophysics, 647, 112-131. Salfity, J.A., Marquillas, R.A., 1981. Las unidades estratigráficas cretácicas del Norte de Argentina. In: Volkheimer, W., Musacchio, E. (Eds.), Cuencas Sedimentarias del Jurásico y Cretácico de América del Sur, 1, 303-317.

Paleoserranus lakamhae gen. et sp. nov., a Paleocene seabass (Perciformes: Serranidae) from Palenque, Chiapas, southeastern Mexico

NASA Astrophysics Data System (ADS)

Cantalice, Kleyton M.; Alvarado-Ortega, Jesús; Alaniz-Galvan, Abril

2018-04-01

Paleoserranus lakamhae gen. et sp. nov. is here described based on well-preserved fossils from the Paleocene marine sediments of the Tenejapa-Lacandón geological unit, belonging to both Division del Norte and Belisario Domínguez quarries, near Palenque, Chiapas, southeastern Mexico. This species exhibits distinctive characters of the order Perciformes, such as the presence of spines in the dorsal, pelvic, and anal fins, as well as the pelvic and pectoral girdles in contact between them. This fish also has neither procurrent spur nor posterior uroneural, characters that support its place within the family Serranidae. It also has a distinctive combination of characters, including a serrated lacrimal and a toothed ectopterygoid, never recorded before among serranids. Additionally, this fossil fish shares some characters with different species nested within the subfamilies Serraninae, Anthiinae, and Ephinephelinae; these include a predorsal formula of 0/0/0 + 2/1 + 1/1; a preopercle with its ventral edge sinuous and showing a strong antrorse spine; its dorsal fin consists of nine spines and eight to ten soft rays; 13 rays in its pectoral fin; and its rounded caudal fin structured with formula I+8-7+I. Paleoserranus lakamhae gen. et sp. nov. is a Serranidae incertae sedis because it does not fit into any subgroup; however, this Paleocene fish is the earliest fossil record of the family Serranidae. The place of occurrence of this new fossil record suggests that the origin and of the seabasses took place in the Caribbean region of North America.

The November 15, 2006 Kuril Islands-Generated Tsunami in Crescent City, California

NASA Astrophysics Data System (ADS)

Dengler, L.; Uslu, B.; Barberopoulou, A.; Yim, S. C.; Kelly, A.

2009-02-01

On November 15, 2006, Crescent City in Del Norte County, California was hit by a tsunami generated by a M w 8.3 earthquake in the central Kuril Islands. Strong currents that persisted over an eight-hour period damaged floating docks and several boats and caused an estimated 9.2 million in losses. Initial tsunami alert bulletins issued by the West Coast Alaska Tsunami Warning Center (WCATWC) in Palmer, Alaska were cancelled about three and a half hours after the earthquake, nearly five hours before the first surges reached Crescent City. The largest amplitude wave, 1.76-meter peak to trough, was the sixth cycle and arrived over two hours after the first wave. Strong currents estimated at over 10 knots, damaged or destroyed three docks and caused cracks in most of the remaining docks. As a result of the November 15 event, WCATWC changed the definition of Advisory from a region-wide alert bulletin meaning that a potential tsunami is 6 hours or further away to a localized alert that tsunami water heights may approach warning- level thresholds in specific, vulnerable locations like Crescent City. On January 13, 2007 a similar Kuril event occurred and hourly conferences between the warning center and regional weather forecasts were held with a considerable improvement in the flow of information to local coastal jurisdictions. The event highlighted the vulnerability of harbors from a relatively modest tsunami and underscored the need to improve public education regarding the duration of the tsunami hazards, improve dialog between tsunami warning centers and local jurisdictions, and better understand the currents produced by tsunamis in harbors.

Schizopolis: Border Cinema and the Global City (of Angels)

ERIC Educational Resources Information Center

Fojas, Camilla

2006-01-01

The films "Star Maps" and "El Norte" reveal the real political, socioeconomic, and psychic costs of divided cities by bringing the simulated realities of mass media to their logical end, thereby sacrificing each character to the disorder of the city. In "Star Maps", Carlos dreams of becoming the next major Latino…

Managing the Environmental Impacts of Growth Under Climate Change: A Workshop for State and Local Decision-Makers--Workshop Summary

EPA Science Inventory

From November 8/9, 2011, the U.S. Environmental Protection Agency (EPA) hosted a workshop titled "Managing the Environmental Impacts of Growth Under Climate Change." The Office of Research and Development (ORD) organized the meeting, which was held in Research Triangle Park, Nort...

Parental Strategies in Contrasting Cultural Settings: Families in Mexico and "El Norte."

ERIC Educational Resources Information Center

Reese, Leslie

2002-01-01

Compared the child-rearing practices and values of low-income Mexican immigrants raising their children in the United States with those of their siblings raising children in Mexico, discussing family accommodation within the ecocultural niche, variation in ecocultural contexts, effects of immigration, cultural change of different types, and…

Hazardous Waste Cleanup: HQ 10th MTN Division & Fort Drum in Fort Drum, New York

EPA Pesticide Factsheets

HQ 10th MTN Division & Fort Drum facility is located at Jones Street and Off North Memorial Drive, in Fort Drum, in the northern portion of New York State approximately 10 miles northeast of Watertown. Fort Drum is the largest Army installation in the nort

Albedo estimation using near infrared photography at Glaciar Norte of Citlaltepetl Volcano (Mexico).

NASA Astrophysics Data System (ADS)

Ontiveros, Guillermo; Delgado-Granados, Hugo

2015-04-01

In this work we show preliminary results of the application of the methodology proposed by Corripio (2004) for albedo estimation of a glacial surface using oblique photography. This analysis was performed for the Glaciar Norte of Citlaltepetl volcano (Mexico), using images obtained with a modified digital camera for capturing the portion of the near infrared spectrum starting at 950 nm and a digital elevation model with a grid of 2 m. The main goal was to obtain a picture of the spatial distribution of albedo on the glacier, in order to find out if there was any morphological evidence of the influence of the glacier energy balance. Some of the obtained results show a certain spatial distribution with comparatively higher albedo values at the lower parts of the glacier as compared with higher parts. The higher values may correspond to different metamorphism of snow/ice at different heights due to the effects of lower slope. Corripio, J. G. (2004). Snow surface albedo estimation using terrestrial photography. International journal of remote sensing, 25(24), 5705-5729.

VizieR Online Data Catalog: Properties of late M-dwarfs (Janson+, 2014)

NASA Astrophysics Data System (ADS)

Janson, M.; Bergfors, C.; Brandner, W.; Kudryavtseva, N.; Hormuth, F.; Hippler, S.; Henning, T.

2017-03-01

The targets in this study were selected from the Lepine & Gaidos (2011, J/AJ/142/138) sample, where stars with a spectral type (SpT) estimate of M5 or later were selected if they were sufficiently bright (J <= 10.0 mag) and sufficiently far north (>-15°) to be meaningfully observed with AstraLux Norte. In total, this gave an input sample of 408 potential targets, of which 286 were actually observed. All observations in this program were acquired with the AstraLux Norte camera on the 2.2 m telescope at Calar Alto in Spain. The 2.2 m telescope is on an equatorial mount. AstraLux uses an Andor DV887-UVB camera head equipped with a thinned, back-illuminated, electron-multiplying 512 x 512 pixel monolithic CCD. The CCD is equipped with two readout registers, one for conventional readout, and one 536 stage electron multiplication register. Each of the two registers comes with its own output amplifier. All Lucky Imaging data were obtained using the electron multiplication mode, and the associated output amplifier. (3 data files).

[Prevalence of American trypanosomiasis, syphilis, toxoplasmosis, rubella, hepatitis B, hepatitis C, human immunodeficiency virus infection, assayed through serological tests among pregnant patients, from 1996 to 1998, at the Regional University Hospital Norte do Paraná].

PubMed

Reiche, E M; Morimoto, H K; Farias, G N; Hisatsugu, K R; Geller, L; Gomes, A C; Inoue, H Y; Rodrigues, G; Matsuo, T

2000-01-01

In order to evaluate the seroprevalence of the american trypanosomiasis, syphilis, toxoplasmosis, rubella, hepatitis B infection, hepatitis C infection and human immunodeficiency virus infection among pregnant women attended at the Hospital Universitário Regional Norte do Paraná, Londrina State University, Paraná, a retrospective study of the serologic results performed in the prenatal routine during the period of June 1996 to June 1998 was carried out. The rates of seropositivity were as follows: american trypanosomiasis = 0.9%, syphilis = 1.6%, toxoplasmosis = 67% (IgG) and 1.8% (IgM), rubella = 89% (IgG) and 1.2% (IgM), hepatitis B surface antigen = 0.8%, hepatitis C virus = 0.8% and human immunodeficiency virus infection = 0.6%. An association between the increase in the seroprevalence of Chagas' disease and patient age was detected (p=0.006). The results underscore the importance of the serological tests in perinatal care, to prevent both the congenital and perinatally transmitted forms of theses infectious diseases.

Nearshore Coastal Dynamics on a Sea-Breeze Dominated Micro-Tidal Beach (NCSAL)

NASA Astrophysics Data System (ADS)

Torres-Freyermuth, A.; Puleo, J. A.; Ruiz de Alegría-Arzaburu, A.; Figlus, J.; Mendoza, T.; Pintado-Patino, J. C.; Pieterse, A.; Chardon-Maldonado, P.; DiCosmo, N. R.; Wellman, N.; Garcia-Nava, H.; Palemón-Arcos, L.; Roberts, T.; López-González, J.; Bravo, M.; Ojeda, E.; Medellín, G.; Appendini, C. M.; Figueroa, B.; González-Leija, M.; Enriquez, C.; Pedrozo-Acuña, A.; Salles, P.

2014-12-01

A comprehensive field experiment devoted to the study of coastal processes on a micro-tidal beach was conducted from March 30th to April 12th 2014 in Sisal, Yucatán México. Wave conditions in the study area are controlled by local (i.e., sea-breezes) and meso-scale (i.e., Nortes) meteorological events. Simultaneous measurements of waves, tides, winds, currents, sediment transport, runup, and beach morphology were obtained in this experiment. Very dense nearshore instrumentation arrays allow us the study of the cross-/along- shore variability of surf/swash zone dynamics during different forcing conditions. Strong sea-breeze wind events produced a diurnal cycle with a maximum wind speed of 14 m/s. The persistent sea-breeze system forces small-amplitude (Hs<1 m) short-period (Tp<4 s) NE waves approaching with a high incidence wave angle. These wave conditions drive westward alongshore currents of up to 0.6 m/s in the inner surf zone and hence produce an active sediment transport in the swash zone. On the other hand, the more energetic (Hs>1 m) Norte event, lasting 48 hours, reached the coast on April 8th generating a long-period swell (Tp>10 s) arriving from the NNW. This event induced an eastward net sediment transport across a wide surf zone. However, long-term observations of sand impoundment at a groin located near the study area suggests that the net sediment transport in the northern Yucatan peninsula is controlled by sea-breeze events and hence swash zone dynamics play an important role in the net sediment budget of this region. A comparative study of surf and swash zone dynamics during both sea-breeze and Norte events will be presented. The Institute of Engineering of UNAM, throughout an International Collaborative Project with the University of Delaware, and CONACYT (CB-167692) provided financial support. The first author acknowledges ONR Global for providing financial support throughout the Visiting Scientist Program.

Speciation and quantification of Hg in sediments contaminated by artisanal gold mining in the Gualaxo do Norte River, Minas Gerais, SE, Brazil.

PubMed

da Penha Rhodes, Valdilene; de Lena, Jorge Carvalho; Santolin, Camila Vidal Alves; da Silva Pinto, Thais; Mendes, Louise Aparecida; Windmöller, Cláudia Carvalhinho

2017-12-28

The Iron Quadrangle in SE Brazil was, in the eighteenth century, one of the most important Au producing regions of Brazil. In this region, gold is produced, even today, by artisanal methods that use Hg to increase the extraction efficiency with no control of Hg release to water systems and the atmosphere. In this context, the Gualaxo do Norte River is of particular interest; its springs are located in the Doce River basin, an important Brazilian basin that supplies water for 3.5 million people. The main goal of this work was to quantify and speciate the Hg in the sediments of the Gualaxo do Norte River using a direct mercury analyzer and gas chromatography-pyrolysis-atomic fluorescence detection system. Statistical analyses consisted of principal component analysis, aiming to assess interactions among elements and species and to group the variables in factors affecting the properties of sediment. The results show that total Hg (THg) and methylmercury (CH 3 Hg + ) concentrations in samples ranged from 209 to 1207 μg kg -1 and from 0.07 to 1.00 μg kg -1 , respectively (methylation percentages from 0.01 to 0.27%). Thermal desorption analysis showed that mercury is mainly present in the oxidized form, and correlation analyses pointed to a relationship between THg and MnO, indicating that manganese can oxidize and/or adsorb Hg. Together, MO and CH 3 Hg + are important parameters in the third principal component, indicating the influence of OM on the methylation process. This first investigation on Hg methylation in this small-scale gold mining area points to the possibility of Hg bioaccumulation and to the need of better understanding the biogeochemical cycle of Hg in this area. Samples were collected in 2012, prior to the 2015 Fundão Dam disaster. The results are also a record of the characteristics of the sediment prior to that event.

Animal-based folk remedies sold in public markets in Crato and Juazeiro do Norte, Ceará, Brazil.

PubMed

Ferreira, Felipe S; Brito, Samuel V; Ribeiro, Samuel C; Saraiva, Antônio A F; Almeida, Waltécio O; Alves, Rômulo R N

2009-06-03

Human communities consistently develop a detailed knowledge of the therapeutical and medicinal properties of the local flora and fauna, and these folk remedies often substitute medicines produced by the pharmaceutical industry. Animals (and their derived products) are essential ingredients in the preparation of many traditional remedies. The present work prepared an inventory of the animals sold in public markets in the cities of Crato and Juazeiro do Norte, Ceará State, Brazil. Information was obtained through the use of semi-structured questionnaires in interviews held with 27 merchants of medicinal animals (18 in the municipality of Juazeiro do Norte [11 men and 7 women] and 9 people in the municipality of Crato [6 men and 3 women]). We calculated the Informant Consensus Factor (ICF) to determine the consensus over which species are effective for particular ailments, as well as the species Use Value (UV) to determine the extent of utilization of each species. A total of 31 animal species, distributed among 21 families were identified as being used medicinally. The taxa most represented were: insects (8 species), mammals (7), fish (5), reptiles (5) and birds (4). The animals sold in these markets are used to treat a total of 24 ailments, with rheumatism, asthma, and inflammations having the largest numbers of citations. Three species not previously reported as having medicinal use were encountered: Leporinus steindachneri (utilized for treating cholesterol problems), Gryllus assimilis (utilized in treating urinary infections), and Phrynops tuberosus (used to treat asthma, rheumatism and bruises). The composition of the local fauna, the popular culture, and commercial considerations are factors that maintain and drive the market for therapeutic animal products - and the lack of monitoring and regulation of this commerce is worrisome from a conservationist perspective. A detailed knowledge of the fauna utilized in alternative medicine is fundamental to the conservation and rational use of the Brazilian fauna.

Animal-based folk remedies sold in public markets in Crato and Juazeiro do Norte, Ceará, Brazil

PubMed Central

Ferreira, Felipe S; Brito, amuel V; Ribeiro, Samuel C; Saraiva, Antônio AF; Almeida, Waltécio O; Alves, Rômulo RN

2009-01-01

Background Human communities consistently develop a detailed knowledge of the therapeutical and medicinal properties of the local flora and fauna, and these folk remedies often substitute medicines produced by the pharmaceutical industry. Animals (and their derived products) are essential ingredients in the preparation of many traditional remedies. The present work prepared an inventory of the animals sold in public markets in the cities of Crato and Juazeiro do Norte, Ceará State, Brazil. Methods Information was obtained through the use of semi-structured questionnaires in interviews held with 27 merchants of medicinal animals (18 in the municipality of Juazeiro do Norte [11 men and 7 women] and 9 people in the municipality of Crato [6 men and 3 women]). We calculated the Informant Consensus Factor (ICF) to determine the consensus over which species are effective for particular ailments, as well as the species Use Value (UV) to determine the extent of utilization of each species. Results A total of 31 animal species, distributed among 21 families were identified as being used medicinally. The taxa most represented were: insects (8 species), mammals (7), fish (5), reptiles (5) and birds (4). The animals sold in these markets are used to treat a total of 24 ailments, with rheumatism, asthma, and inflammations having the largest numbers of citations. Three species not previously reported as having medicinal use were encountered: Leporinus steindachneri (utilized for treating cholesterol problems), Gryllus assimilis (utilized in treating urinary infections), and Phrynops tuberosus (used to treat asthma, rheumatism and bruises). Conclusion The composition of the local fauna, the popular culture, and commercial considerations are factors that maintain and drive the market for therapeutic animal products – and the lack of monitoring and regulation of this commerce is worrisome from a conservationist perspective. A detailed knowledge of the fauna utilized in alternative medicine is fundamental to the conservation and rational use of the Brazilian fauna. PMID:19493345

Evaluation of emission control strategies to reduce ozone pollution in the Paso del Norte region using a photochemical air quality modeling system

NASA Astrophysics Data System (ADS)

Valenzuela, Victor Hugo

Air pollution emissions control strategies to reduce ozone precursor pollutants are analyzed by applying a photochemical modeling system. Simulations of air quality conditions during an ozone episode which occurred in June, 2006 are undertaken by increasing or reducing area source emissions in Ciudad Juarez, Chihuahua, Mexico. Two air pollutants are primary drivers in the formation of tropospheric ozone. Oxides of nitrogen (NOx) and volatile organic compounds (VOC) undergo multiple chemical reactions under favorable meteorological conditions to form ozone, which is a secondary pollutant that irritates respiratory systems in sensitive individuals especially the elderly and young children. The U.S. Environmental Protection Agency established National Ambient Air Quality Standards (NAAQS) to limit ambient air pollutants such as ozone by establishing an 8-hour average concentration of 0.075 ppm as the threshold at which a violation of the standard occurs. Ozone forms primarily due reactions in the troposphere of NOx and VOC emissions generated primarily by anthropogenic sources in urban regions. Data from emissions inventories indicate area sources account for ˜15 of NOx and ˜45% of regional VOC emissions. Area sources include gasoline stations, automotive paint bodyshops and nonroad mobile sources. Multiplicity of air pollution emissions sources provides an opportunity to investigate and potentially implement air quality improvement strategies to reduce emissions which contribute to elevated ozone concentrations. A baseline modeling scenario was established using the CAMx photochemical air quality model from which a series of sensitivity analyses for evaluating air quality control strategies were conducted. Modifications to area source emissions were made by varying NOx and / or VOC emissions in the areas of particular interest. Model performance was assessed for each sensitivity analysis. Normalized bias (NB) and normalized error (NE) were used to identify variability of the PREDICTED to OBSERVED ozone concentrations of both BASELINE model and simulations with modified emissions assessed by the sensitivity analysis. All simulations were found to vary within acceptable ranges of these two criteria variables. Simulation results indicate ozone formation in the PdN region is VOC-limited. Under VOC-limited conditions, modifications to NOx emissions do not produce a marked increase or decrease in ozone concentrations. Modifications to VOC emissions generated the highest variability in ozone concentrations. Increasing VOC emissions by 75% produced results which minimized model bias and error when comparing PREDICTED and OBSERVED ozone concentrations. Increasing VOC emissions by 75% either alone or in combination with a 75% increase in NOx emissions generated PREDICTED ozone concentrations very near to OBSERVED ozone. By evaluating the changes in ambient ozone concentrations through photochemical modeling, air quality planners may identify the most efficient or effective VOC emissions control strategies for area sources. Among the strategies to achieve emissions reductions are installation of gasoline vapor recovery systems, replacing high-pressure low-volume surface coating paint spray guns with high-volume low-pressure spray paint guns, requiring emissions control booths for surface coating operations as well as undertaking solvent management practices, requiring the sale of low VOC paint solvents in the surface-coating industry, and requiring low-VOC solvents in the dry cleaning industry. Other strategies to reduce VOC emissions include initiating Eco-Driving strategies to reduce fuel consumption from mobile sources and minimize vehicle idling at the international ports of entry by reducing bridge wait times. This dissertation depicts a tool for evaluating impacts of emissions on regional air quality by addressing the highly unresolved fugitive emissions in the Paso del Norte region. It provides a protocol for decision makers to assess the effects of various emission control strategies in the region. Impacts of specific source categories such as the international ports of entry, gasoline stations, paint body shops, truck stops, and military installations on the regional air quality can be easily and systematically addressed in a timely manner in the future.

PIA Program | CTIO

Science.gov Websites

se cuenta con los fondos necesarios para efectuar el Programa PIA para el 2018. We do, on occasion Observatorio Inter-Americano de Cerro Tololo es el centro nacional de los Estados Unidos para el desarrollo de unos 400 kms al norte de Santiago. Los telescopios se ubican en la cima de Cerro Tololo, a 90 kms al

Keeping Score without the Body Count: Measuring Counterinsurgent Effectiveness According to Insurgent Tangible Resources

DTIC Science & Technology

2013-05-23

down tanks. The tank’s advantage is so obvious that the image is almost comical . An insurgent also typically cannot penetrate the base perimeter of a......92. 32 Ibid., 93. 33 Mao Zedong, The Red Book of Guerrilla Warfare, trans. Chen Song, ed. Shawn Conners (El Paso, TX: Norte Press, 2008) Kindle

PCR reveals high prevalence of non-sporulating Nosema bombi(Microsporidia) infections in bumble bees (Bombus)in northern Arizona

USDA-ARS?s Scientific Manuscript database

About 20% of bumble bee species are in decline in North America, and the microsporidian pathogen, Nosema bombi, may be a factor in these declines. We performed a comprehensive survey of N. bombi infections in the bumble bee communities throughout the flight season along an elevation gradient in Nort...

Two new species of Aulospongus Norman, 1878 with a key to the Atlantic species (Poecilosclerida; Demospongiae; Porifera).

PubMed

Cavalcanti, Thaynã; Santos, George Garcia; Pinheiro, Ulisses

2014-07-03

We describe two new species: Aulospongus trirhabdostylus sp. nov. and Aulospongus mandela sp. nov. from Potiguar Basin (Rio Grande do Norte State, Northeastern Brazil). Both species were compared with their congeners and an identification key for the Atlantic species of Aulospongus is provided. The genus Aulospongus now contains 16 species.

Adolescent Drug Use in Mexico and among Mexican American Adolescents in the United States: Environmental Influences and Individual Characteristics.

ERIC Educational Resources Information Center

Felix-Ortiz, Maria; Velazuez, Jorge A Villatoro; Medina-Mora, Maria Elena; Newcomb, Michael D.

2001-01-01

Compares cigarette, alcohol, and illegal drug use among high school students in Baja California Norte (BCN), Mexico with Mexican American students in Los Angeles (LA), California (N=516). Demographic variables, individual characteristics, and environmental influences were considered. Reports that more BCN students used alcohol and more LA students…

Programa de conservacion para aves migratorias neotropicales

Treesearch

Deborah Finch; Marcia Wilson; Roberto Roca

1992-01-01

Mas de 250 especies de aves terrestres migran a Norte America durante la epoca reproductiva para aprovechar los sistemas templados. No obstante, las aves migratorias neotropicales pasan la mayor parte de su ciclo de vida en los habitat tropicales y subtropicales de paises latinoamericanos y caribefios donde viven en una asociacion cercana con las aves residentes. Para...

76 FR 62060 - NortHydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

...-long underground penstock that would collect water from the Scooteney wasteway; (2) a powerhouse containing one turbine/generator unit with a capacity of 1,110 kilowatts; (3) a 4.2- mile-long, 115-kilovolt.... The wasteway functions as a diversion of surplus water from the irrigation system to the existing...

Revisiting Jorullo volcano (Mexico): monogenetic or polygenetic volcano?

NASA Astrophysics Data System (ADS)

Delgado Granados, H.; Roberge, J.; Farraz Montes, I. A.; Victoria Morales, A.; Pérez Bustamante, J. C.; Correa Olan, J. C.; Gutiérrez Jiménez, A. J.; Adán González, N.; Bravo Cardona, E. F.

2007-05-01

Jorullo volcano is located near the volcanic front of the westernmost part of the Trans-Mexican Volcanic Belt, which is related to the subduction of the Cocos plate beneath the North American plate. This part of the TMVB is known as the Michoacán-Guanajuato Volcanic Field, a region where widespread monogenetic volcanism is present although polygenetic volcanism is also recognized (i. e. Tancítaro volcano; Ownby et al., 2006). Jorullo volcano was born in the middle of crop fields. During its birth several lava flows were emitted and several cones were constructed. The main cone is the Jorullo proper, but there is a smaller cone on the north (Volcán del Norte), and three smaller cones aligned N-S on the south (Unnamed cone, UC; Volcán de Enmedio, VE; and Volcán del Sur, VS). The cone of Jorullo volcano is made up of tephra and lava flows erupted from the crater. The three southern cones show very interesting histories not described previously. VE erupted highly vesiculated tephras including xenoliths from the granitic basement. VS is made of spatter and bombs. A very well preserved hummocky morphology reveals that VE and VS collapsed towards the west. After the collapses, phreatomagmatic activity took place at the UC blanketing VE, VS and the southern flank of the Jorullo cone with sticky surge deposits. The excellent study by Luhr and Carmichael (1985) indicates that during the course of the eruption, lavas evolved from primitive basalt to basaltic andesite, although explosive products show a reverse evolution pattern (Johnson et al., 2006). We mapped lava flows not described by the observers in the 18th century nor considered in previous geologic reports as part of the Jorullo lavas. These lavas are older, distributed to the west and south, and some of them resemble the lava flows from La Pilita volcano, a cone older than Jorullo (Luhr and Carmichael, 1985). These lava flows were not considered before because they were not extruded during the 1759-1774 eruption. Therefore, in spite of the long-standing idea of Jorullo being a monogenetic volcano, we hypothesize it as a stratovolcano in the making. The polygenetic nature of the volcano and the processes described here for Jorullo volcano (cone collapse, phreatomagmatic activity) are of great importance because of their implications for hazards assessment.

Patterns of Global Terrorism: 1997.

DTIC Science & Technology

1998-04-01

four Colombian Coca - Cola employees at a roadblock in Norte de Santander. The rebels seek individual ransoms and a payoff from Coca - Cola to prevent...further kidnappings and have approached other Coca - Cola officials demanding a protection payoff. 23 December Pakistan Unidentified assailants...economic sanctions on Sudan for its sponsorship of international terrorism, its efforts to destabilize neighboring countries, and its abysmal human

World Epidemiology Review, Number 90

DTIC Science & Technology

1978-01-12

Bom Jesus and Aurora do Norte. This was reported to Agriculture Minister Alysson Paulinelli in Brasilia by Antonio Augusto Azeredo Coutinho, the...municipios of Dianopolis, Ponte Alta de Bom Jesus , Almas and Alvorada to observe the situation. He confirmed that the rabies outbreak has affected...department has established a system of epidemiological vigilance, which consists of receiving, every 7 days, information from all municipal hospitals

Identification of novel QTL for sawfly resistance in wheat

Treesearch

J. D. Sherman; D. K. Weaver; M. L. Hofland; S. E. Sing; M. Buteler; S. P. Lanning; Y. Naruoka; F. Crutcher; N. K. Blake; J. M. Martin; P. F. Lamb; G. R. Carlson; L. E. Talbert

2010-01-01

The wheat stem sawfly (WSS) (Cephus cinctus Nort.) is an important pest of wheat (Triticum aestivum L. em. Thell.) in the Northern Great Plains. This paper reports the genetic analysis of antixenosis for egg-laying WSS females in recombinant inbred lines (RIL) of hard red spring wheat. Female WSS preferentially choose certain wheat genotypes for egg-laying, with the...

76 FR 62060 - NortHydro, LLC.; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... with a powerhouse; (3) two turbine/generator units with a combined capacity of 1,600 kilowatts; (4) a 7.... The wasteway functions as a diversion of surplus water from the irrigation system. The sole purpose of.... The following new facilities are proposed: (1) A diversion structure that would collect water from the...

76 FR 62061 - NortHydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... powerhouse; (3) three turbine/generator units with a combined capacity of 1,750 kilowatts; (4) a 7.5-mile... wasteway functions as a diversion of surplus water from the irrigation system. The sole purpose of a... facilities are proposed: (1) A diversion structure that would collect water from the wasteway; (2) three 63...

[Community perception on the quality of public health services delivery in the Norte and Ichilo districts of Bolivia].

PubMed

Gattinara, B C; Lbacache, J; Puente, C T; Giaconi, J; Caprara, A

1995-01-01

The current study identifies the people perception on the quality of public health services in Norte and Ichilo health districts (Bolivia), with a particular emphasis on the relationship between heath workers and patients. Both qualitative and quantitative methods were utilised such as: survey, focus groups, participatory observation, unstructured interviews to Key informants and open discussions with the community. Results show that the public health services reputation is affected by elements as discriminatory attitude towards people belonging to a low socio-economic strata, lack of communication between health workers and patients, perceived insufficient technical skills and recognition of a low therapeutic efficacy. The people who are coming from highlands (collas) appear as the most disappointed by the health service provision structured on the western predominant pattern with a top-bottom approach ignoring its potential users' expectations and needs. A low capability of the public health services to accept and recognise the inter-cultural features of the region, makes that the challenge to be undertaken by the district health personnel should focus on the establishment of intercultural bridges between the public health service providers and the potential patients, as well as among the different co-existing medical systems.

Mercury Pollution from Small-Scale Gold Mining Can Be Stopped by Implementing the Gravity-Borax Method--A Two-Year Follow-Up Study from Two Mining Communities in the Philippines.

PubMed

Køster-Rasmussen, Rasmus; Westergaard, Maria L; Brasholt, Marie; Gutierrez, Richard; Jørs, Erik; Thomsen, Jane F

2016-02-01

Mercury is used globally to extract gold in artisanal and small-scale gold mining. The mercury-free gravity-borax method for gold extraction was introduced in two mining communities using mercury in the provinces Kalinga and Camarines Norte. This article describes project activities and quantitative changes in mercury consumption and analyzes the implementation with diffusion of innovations theory. Activities included miner-to-miner training; seminars for health-care workers, school teachers, and children; and involvement of community leaders. Baseline (2011) and follow-up (2013) data were gathered on mining practices and knowledge about mercury toxicology. Most miners in Kalinga converted to the gravity-borax method, whereas only a few did so in Camarines Norte. Differences in the nature of the social systems impacted the success of the implementation, and involvement of the tribal organization facilitated the shift in Kalinga. In conclusion, the gravity-borax method is a doable alternative to mercury use in artisanal and small-scale gold mining, but support from the civil society is needed. © The Author(s) 2016.

Multidrug-resistant pulmonary tuberculosis in Los Altos, Selva and Norte regions, Chiapas, Mexico.

PubMed

Sánchez-Pérez, H J; Díaz-Vázquez, A; Nájera-Ortiz, J C; Balandrano, S; Martín-Mateo, M

2010-01-01

To analyse the proportion of multidrug-resistant tuberculosis (MDR-TB) in cultures performed during the period 2000-2002 in Los Altos, Selva and Norte regions, Chiapas, Mexico, and to analyse MDR-TB in terms of clinical and sociodemographic indicators. Cross-sectional study of patients with pulmonary tuberculosis (PTB) from the above regions. Drug susceptibility testing results from two research projects were analysed, as were those of routine sputum samples sent in by health personnel for processing (n = 114). MDR-TB was analysed in terms of the various variables of interest using bivariate tests of association and logistic regression. The proportion of primary MDR-TB was 4.6% (2 of 43), that of secondary MDR-TB was 29.2% (7/24), while among those whose history of treatment was unknown the proportion was 14.3% (3/21). According to the logistic regression model, the variables most highly associated with MDR-TB were as follows: having received anti-tuberculosis treatment previously, cough of >3 years' duration and not being indigenous. The high proportion of MDR cases found in the regions studied shows that it is necessary to significantly improve the control and surveillance of PTB.

The sandfly fauna, anthropophily and the seasonal activities of Pintomyia spinicrassa (Diptera: Psychodidae: Phlebotominae) in a focus of cutaneous leishmaniasis in northeastern Colombia

PubMed Central

Ovallos, Fredy Galvis; Silva, Yanis Ricardo Espinosa; Fernandez, Nelson; Gutierrez, Reynaldo; Galati, Eunice Aparecida Bianchi; Sandoval, Claudia Magaly

2013-01-01

This study was conducted to identify the sandfly fauna and the anthropophilic species in a coffee-growing area of Villanueva, Norte de Santander, Colombia, a focus of American cutaneous leishmaniasis, and to analyse the relationship between the most frequent species and rainfall, relative humidity and temperature, with the aim of contributing to epidemiological surveillance in the area. Sandfly collections were performed fortnightly between February 2006-September 2007 using automatic light traps, Shannon traps, protected human bait and aspiration in resting places. A total of 7,051 sandflies belonging to 12 species were captured. Pintomyia spinicrassa (95.7%) predominated. Pintomyia oresbia and Lutzomyia sp. of Pichinde were found in the state of Norte de Santander for the first time. Pi. spinicrassa, Pintomyia nuneztovari, Micropygomyia venezuelensis, Lutzomyia (Helcocyrtomyia) scorzai and Lu. (Helcocyrtomyia) sp. were captured on the protected human bait. A significant association between Pi. spinicrassa abundance and the total rainfall and the average temperature and humidity 10 days before the collection was observed. The dominance of Pi. spinicrassa, a recognised vector of Leishmania braziliensis, especially during the dry periods, indicates that the risk of parasite transmission may increase. PMID:23778653

The sandfly fauna, anthropophily and the seasonal activities of Pintomyia spinicrassa (Diptera: Psychodidae: Phlebotominae) in a focus of cutaneous leishmaniasis in northeastern Colombia.

PubMed

Ovallos, Fredy Galvis; Silva, Yanis Ricardo Espinosa; Fernandez, Nelson; Gutierrez, Reynaldo; Galati, Eunice Aparecida Bianchi; Sandoval, Claudia Magaly

2013-05-01

This study was conducted to identify the sandfly fauna and the anthropophilic species in a coffee-growing area of Villanueva, Norte de Santander, Colombia, a focus of American cutaneous leishmaniasis, and to analyse the relationship between the most frequent species and rainfall, relative humidity and temperature, with the aim of contributing to epidemiological surveillance in the area. Sandfly collections were performed fortnightly between February 2006-September 2007 using automatic light traps, Shannon traps, protected human bait and aspiration in resting places. A total of 7,051 sandflies belonging to 12 species were captured. Pintomyia spinicrassa (95.7%) predominated. Pintomyia oresbia and Lutzomyia sp. of Pichinde were found in the state of Norte de Santander for the first time. Pi. spinicrassa, Pintomyia nuneztovari, Micropygomyia venezuelensis, Lutzomyia (Helcocyrtomyia) scorzai and Lu. (Helcocyrtomyia) sp. were captured on the protected human bait. A significant association between Pi. spinicrassa abundance and the total rainfall and the average temperature and humidity 10 days before the collection was observed. The dominance of Pi. spinicrassa, a recognised vector of Leishmania braziliensis, especially during the dry periods, indicates that the risk of parasite transmission may increase.

[Irrigated perimeters as a geopolitical strategy for the development of the semi-arid region and its implications for health, labor and the environment].

PubMed

Pontes, Andrezza Graziella Veríssimo; Gadelha, Diego; Freitas, Bernadete Maria Coêlho; Rigotto, Raquel Maria; Ferreira, Marcelo José Monteiro

2013-11-01

An analysis was made of irrigated perimeters as a geopolitical strategy for expanding Brazilian agricultural frontiers and the "development" of the northeastern semi-arid region with respect to social determinants in health in rural communities. Research was conducted in the Chapada do Apodi in the states of Ceará and Rio Grande do Norte between 2007 and 2011. Various research techniques and tools were adopted, such as research-action, ethnographic studies, questionnaires and laboratory exams, water contamination analyses, social cartography and focal groups. In the context of agribusiness expansion, it was revealed that public policies of irrigation have had consequences for health, labor and the environment with the implementation of the Jaguaribe-Apodi Irrigated Perimeter in Ceará. The social and environmental conflict and resistance in the phase prior to the installation of the Santa Cruz do Apodi Irrigated Perimeter in Rio Grande do Norte was significant as it had consequences for the health-disease process on rural communities. It is important for the evaluation of public irrigation policies to consider the impacts of the perimeters on the lifestyle, labor, health and the environment of the affected territories.

Evaluating outcome-correlated recruitment and geographic recruitment bias in a respondent-driven sample of people who inject drugs in Tijuana, Mexico

PubMed Central

Rudolph, Abby E.; Gaines, Tommi L.; Lozada, Remedios; Vera, Alicia; Brouwer, Kimberly C.

2015-01-01

Respondent-driven sampling’s (RDS) widespread use and reliance on untested assumptions suggests a need for new exploratory/diagnostic tests. We assessed geographic recruitment bias and outcome-correlated recruitment among 1048 RDS-recruited people who inject drugs (Tijuana, Mexico). Surveys gathered demographics, drug/sex behaviors, activity locations, and recruiter-recruit pairs. Simulations assessed geographic and network clustering of active syphilis (RPR titers≥1:8). Gender-specific predicted probabilities were estimated using logistic regression with GEE and robust standard errors. Active syphilis prevalence was 7% (crude: men=5.7% and women=16.6%; RDS-adjusted: men=6.7% and women=7.6%). Syphilis clustered in the Zona Norte, a neighborhood known for drug and sex markets. Network simulations revealed geographic recruitment bias and non-random recruitment by syphilis status. Gender-specific prevalence estimates accounting for clustering were highest among those living/working/injecting/buying drugs in the Zona Norte and directly/indirectly connected to syphilis cases (men:15.9%, women:25.6%) and lowest among those with neither exposure (men:3.0%, women:6.1%). Future RDS analyses should assess/account for network and spatial dependencies. PMID:24969586

Evaluating outcome-correlated recruitment and geographic recruitment bias in a respondent-driven sample of people who inject drugs in Tijuana, Mexico.

PubMed

Rudolph, Abby E; Gaines, Tommi L; Lozada, Remedios; Vera, Alicia; Brouwer, Kimberly C

2014-12-01

Respondent-driven sampling's (RDS) widespread use and reliance on untested assumptions suggests a need for new exploratory/diagnostic tests. We assessed geographic recruitment bias and outcome-correlated recruitment among 1,048 RDS-recruited people who inject drugs (Tijuana, Mexico). Surveys gathered demographics, drug/sex behaviors, activity locations, and recruiter-recruit pairs. Simulations assessed geographic and network clustering of active syphilis (RPR titers ≥1:8). Gender-specific predicted probabilities were estimated using logistic regression with GEE and robust standard errors. Active syphilis prevalence was 7 % (crude: men = 5.7 % and women = 16.6 %; RDS-adjusted: men = 6.7 % and women = 7.6 %). Syphilis clustered in the Zona Norte, a neighborhood known for drug and sex markets. Network simulations revealed geographic recruitment bias and non-random recruitment by syphilis status. Gender-specific prevalence estimates accounting for clustering were highest among those living/working/injecting/buying drugs in the Zona Norte and directly/indirectly connected to syphilis cases (men: 15.9 %, women: 25.6 %) and lowest among those with neither exposure (men: 3.0 %, women: 6.1 %). Future RDS analyses should assess/account for network and spatial dependencies.

Minisparker profiles from Jeffreys Ledge and adjacent areas in the western Gulf of Maine

USGS Publications Warehouse

Eskenasy, Diane M.; Bailey, Norman G.

1980-01-01

A total of 250 kilometers of single-channel seismic-reflection data (28 minisparker profiles) were collected in the coastal waters of Massachusetts, north of and immediately south of Cape Ann, and on the western flank of Jeffreys Ledge, western Gulf of Maine, during the September 1978 cruise of the R/V ASTERIAS. The survey was conducted by the U.S. Geological Survey as part of the Massachusetts Cooperative Marine Geologic Program.The seismic systems used included a 1Del Norte minisparker and streamer, an Energy International Streamer, and EPC 3200 and 4100 recorders. Navigational control was established by Radar and Loran-C. The Loran-C navigation data were recorded on a Northstar 6000 system.The purpose of the cruise was to discover the significance and extent of the folded and faulted internal reflections that were first noticed on the esternmost tip of Jeffreys Ledge in line 14 of esternmost tip of Jeffreys Ledge in line 14 of rninisparker data from the 1976 R/V FAY 023 cruise.Sixteen northwest-trending lines were run off Cape Ann to investigate the deformed reflectors, now thought to represent a moraine formed by readvance of continental ice over the last glacial marine Presurnpscot Formation. Lines north and south of Cape Ann were run to locate the offshore extension of the Clinton-Newbury and Bloody Bluff fault systems.The original records can be studied at the U.S. Geological Survey offices at Woods Hole, Mass. Microfilm copies of the records can be purchased only from the National Geophysical and Solar-Terrestrial Data Center, NOAA/EDIS/NGSDC, Code D621, 325 Broadway; Boulder, CO 80303 (303-497-6338)

Understanding Changes in Water Availability in the Rio Grande/Rio Bravo del Norte Basin Under the Influence of Large-Scale Circulation Indices Using the Noah Land Surface Model

NASA Technical Reports Server (NTRS)

Khedun, C. Prakash; Mishra, Ashok K.; Bolten, John D.; Beaudoing, Hiroko K.; Kaiser, Ronald A.; Giardino, J. Richard; Singh, Vijay P.

2012-01-01

Water availability plays an important role in the socio-economic development of a region. It is however, subject to the influence of large-scale circulation indices, resulting in periodic excesses and deficits. An assessment of the degree of correlation between climate indices and water availability, and the quantification of changes with respect to major climate events is important for long-term water resources planning and management, especially in transboundary basins as it can help in conflict avoidance. In this study we first establish the correlation of the Pacific Decadal Oscillation (PDO) and El Nino-Southern Oscillation (ENSO) with gauged precipitation in the Rio Grande basin, and quantify the changes in water availability using runoff generated from the Noah land surface model. Both spatial and temporal variations are noted, with winter and spring being most influenced by conditions in the Pacific Ocean. Negative correlation is observed at the headwaters and positive correlation across the rest of the basin. The influence of individual ENSO events, classified using four different criteria, is also examined. El Ninos (La Ninas) generally cause an increase (decrease) in runoff, but the pattern is not consistent; percentage change in water availability varies across events. Further, positive PDO enhances the effect of El Nino and dampens that of La Nina, but during neutral/transitioning PDO, La Nina dominates meteorological conditions. Long El Ninos have more influence on water availability than short duration high intensity events. We also note that the percentage increase during El Ninos significantly offsets the drought-causing effect of La Ninas.

Microbiological and physicochemical factors affecting Aspergillus section Flavi incidence in Cavendish banana (Musa cavendishii) chips production in Southern Philippines.

PubMed

Sales, A C; Azanza, P V; Yoshizawa, T

2005-01-01

Microbiological and physicochemical factors affecting the incidence of Aspergillus section Flavi in dried Cavendish banana (Musa cavendishii) chips production in Southern Philippines were examined. The average counts of Aspergillus section Flavi (AFC) in fresh and dried Cavendish bananas from 10 production batches of the Philippine Agro-Industrial Development Cooperative in Davao del Norte, Southern Philippines were 1.2 x 10(2) and 1.6 x 10(2) cfu/g, respectively. Isolates from both samples were identified to be Aspergillus flavus based on spore type and conidial structure of isolates. An increasing trend in the AFC of Cavendish bananas was observed during dried banana chips processing. Variability in the AFC between production batches was attributed to differences in aerobic and fungal populations and physicochemical characteristics of the fruits, peel damage of the raw materials, concentration of AFC in the air and food-contact surfaces of the production area, and temperature and relative humidity (RH) conditions of the environment during production and storage. Physicochemical characteristics of Cavendish bananas from the receipt of raw materials up to the first day of drying were within the reported range of values allowing growth and toxin production by aflatoxigenic fungi. Air-borne AFC varied depending on the section of the production area examined. The close proximity of the waste disposal area from the production operation to the preparation, drying and storage areas suggests that cross-contamination, probably air-borne or insect-borne was a likely occurrence. The hands of workers were also identified as AFC sources. Results of this study highlight the need for the development of strategies to control aflatoxigenic fungi and aflatoxin contamination in Philippine dried Cavendish bananas.

Science Review for the Scott Bar Salamander (Plethodon asupak) and the Siskiyou Mountains Salamander (P. stormi): Biology, Taxonomy, Habitat, and Detection Probabilities/Occupancy

USGS Publications Warehouse

DeGross, Douglas J.; Bury, R. Bruce

2007-01-01

The Plethodon elongatus Complex in the Klamath-Siskiyou Ecoregion of southern Oregon and northern California includes three species: the Del Norte salamander, Plethodon elongatus; the Siskiyou Mountains salamander, P. stormi; and the Scott Bar salamander, P. asupak. This review aims to summarize the current literature and information available on select topics for P. stormi and P. asupak. These are both terrestrial salamanders belonging to the Family Plethodontidae, which contains more species and has a wider geographic distribution than any other family of salamanders (Wake 1966, 2006; Pough 1989). The genera of this family have greatly diversified ecologically across North America, Central America, northern South America, Sardinia, southeastern France and northwestern Italy, and have recently been discovered on the Korean peninsula (Min et al. 2005). The genus Plethodon is found exclusively in North America and is split into three distinct clades, based upon morphology and phylogenetics (Highton and Larson 1979): eastern small Plethodon, eastern large Plethodon, and the western Plethodon. The western Plethodon are the greatest representation of Plethodontidae in the Pacific Northwest, with 8 species. The two species with the most restricted ranges of these regional congeners are the Siskiyou Mountains and Scott Bar salamanders. These salamanders occupy the interior of the Klamath-Siskiyou Ecoregion which straddles the California and Oregon state lines, between Siskiyou County (CA) and Jackson and Josephine Counties (OR). The relatively recent discovery of P. asupak (Mead et al. 2005) and the limited range of both species have created an environment of uncertain conservation status for these species. This review will focus on four central topics of concern for land and resource managers: Biology; Taxonomy; Habitat; and Detection Probabilities/Occupancy.

Distribution and prevalence of vector-borne diseases in California chipmunks (Tamias spp.).

PubMed

Straub, Mary H; Roy, Austin N; Martin, Amanda; Sholty, Kathleen E; Stephenson, Nicole; Foley, Janet E

2017-01-01

California, with 13 chipmunk (Tamias) species, has more than any other state or country, occupying habitats ranging from chaparral to the high peaks of the Sierra Nevada. Chipmunks host zoonotic pathogens including Yersinia pestis, Anaplasma phagocytophilum, relapsing fever (RF) Borrelia spp., Borrelia burgdorferi, and spotted fever group (SFG) Rickettsia species. Chipmunk species are often not differentiated by public health workers, yet different species utilize different ecological niches and may have intrinsically different capacities for maintaining vector-borne pathogens and infecting vectors. We surveyed over 700 individuals from nine species of chipmunks throughout California for exposure to and infection by Y. pestis, A. phagocytophilum, RF Borrelia spp., Borrelia burgdorferi, and SFG Rickettsia species. DNA of all five pathogens was found and all chipmunks except Merriam's chipmunk (T. merriami) were PCR-positive for at least one of the pathogens. Anaplasma phagocytophilum was most common (40.0%, 2/5) in Sonoma chipmunks (T. sonomae) from Marin county and B. burgdorferi most common (37.5%, 27/72) in redwood chipmunks (T. ochrogenys) from Mendocino county. RF Borrelia spp. was detected in 2% (6/297) of redwood chipmunks in Mendocino county and 10% (1/10) of both least (T. minimus) and lodgepole (T. speciosus) chipmunks in the western Sierra. Exposure to SFG Rickettsia spp. was found in the Northern Coastal region (Del Norte, Humboldt and Mendocino counties) and in the northern and western Sierra in several species of chipmunks. Y. pestis infection was found only in the western Sierra-in a yellow-pine (T. amoenus) and a long-eared (T. quadrimaculatus) chipmunk. Though more data are needed to thoroughly understand the roles that different chipmunk species play in disease transmission, our findings suggest that some chipmunk species may be more important to the maintenance of vector-borne diseases than others within each geographic area.

A green observatory in the Chilean Atacama desert

NASA Astrophysics Data System (ADS)

Ramolla, Michael; Westhues, Christian; Hackstein, Moritz; Haas, Martin; Hodapp, Klaus; Lemke, Roland; Barr Domínguez, Angie; Chini, Rolf; Murphy, Miguel

2016-08-01

Since 2007, the Ruhr-Universität Bochum (RUB) in Germany and Universidad Católica del Norte (UCN) in Chile jointly operate the Universitätssternwarte der Ruhr-Universität Bochum (USB), which is located in direct neighborhood of the future E-ELT of ESO. It is the only observatory powered exclusively by solar panels and wind turbines. Excess power is stored in batteries that allow uninterrupted operation even in windless nights. The scientific equipment consists of three robotic optical telescopes with apertures ranging from 15 cm (RoBoTT) over 25 cm (BESTII) to 40 cm (BMT) and one 80 cm (IRIS) infra-red telescope. The optical telescopes are equipped with Johnson and Sloan broad band filters together with a large number of narrow and intermediate bands. In the infrared, J,H and K filters are available, accompanied by several narrow bands near the K band wavelength. The second Nasmyth focus in the 80 cm telescope feeds a high resolution echelle spectrograph similar to the FEROS instrument of ESO. This variety of instruments has evolved from different collaborations, i.e. with the University of Hawaii (IfA) in the USA, which provided the near-infrared-camera of the IRIS telescope, or with the Deutsches Zentrum für Luft- und Raumfahrt (DLR) in Germany, which provided the BESTII telescope. The highly automatized processes on all telescopes enable a single person to run the whole facility, providing the high cost efficiency required for an university observatory. The excellent site conditions allow projects that require daily observations of astronomical objects over epochs of several months or years. Here we report on such studies of young stellar objects from the Bochum Galactic Disk Survey, the multiplicity of stars, quasar variability or the hunt for exo-planets.

Geological and geochemical reconnaissance in the central Santander Massif, Departments of Santander and Norte de Santander, Colombia

USGS Publications Warehouse

Evans, James George

1976-01-01

The central Santander Massif is composed of Precambrian Bucaramanga Gneiss and pre-Devonian Silgara Formation intruded by Mesozoic quartz diorite, quartz monzonite, and alaskite and Cretaceous or younger porphyry. Triassic (Bocas Formation), Jurassic (Jordan and Giron Formations).and Cretaceous (Tambor, Rosa Blanca, Paja, Tablazo, Simiti, La Luna, and Umir Formations) sedimentary rocks overlie the metamorphic rocks and are younger than most of the intrusions. A geological and geochemical reconnaissance of part of the central Santander Massif included the Vetas and California gold districts. At Vetas the gold is generally in brecciated aphanitic quartz and phyllonite. Dark-gray material in the ore may be graphite. The ore veins follow steep west-northwest- and north-northeast-striking fracture zones. No new gold deposits were found. Additional geochemical studies should concentrate on western Loma Pozo del Rey and on improvement of the gold extraction process. At California the gold is in pyritiferous quartz veins and quartz breccia. Ore containing black sooty material (graphite?) is highly radioactive. Some of the mineralization is post-Lower Cretaceous. Soil samples indicate that gold deposits lie under the thick blanket of soil on the ridges above the zone of mining. Three principal gold targets are outlined by gold and associated minerals in pan concentrates. The close relation of gold and copper anomalies suggests that copper may be useful as a pathfinder for gold elsewhere in the region. Based on occurrences of gold or high concentrations of pyrite or chalcopyrite in pan concentrates and on analytical data, eight potential gold targets are outlined in the central massif. Reconnaissance of the surrounding region is warranted.

Management of pest mole crickets in Florida and Puerto Rico with a nematode and parasitic wasp

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leppla, N.C.; Frank, J.H.; Adjei, M.B.

Non-indigenous invasive mole crickets, Scapteriscus vicinus Scudder (Orthoptera: Gryllotalpidae) in Florida and S. didactylus (Latreille) (the 'changa') in Puerto Rico, are being managed with an entomopathogenic nematode, Steinernema scapterisci (Nguyen and Smart) (Rhabditida: Steinernematidae), and a parasitic wasp, Larra bicolor L. (Hymenoptera: Sphecidae). Pest mole cricket populations have declined by 95% in north central Florida since these specialist natural enemies were released and established in the 1980s. Commercial production of the nematode was initiated, nearly 70 billion were applied in 34 Florida counties, and their establishment, spread, and impact on mole crickets were monitored. The infected mole crickets dispersed themore » nematode rapidly, so that within 6 months these parasites were present in most of the insects trapped in experimental pastures. Three years later, mole cricket populations were reduced to acceptable levels and the bahiagrass had recovered. The nematode was released for the first time in Puerto Rico during 2001 and has persisted; the wasp was introduced in the late 1930s. The geographical distribution of the wasp is being expanded in Florida and Puerto Rico by planting plots of Spermacoce verticillata (L.), a wildflower indigenous to Puerto Rico and widely distributed in southern Florida. Pastures, sod farms, golf courses, landscapes, and vegetable farms in Florida and Puerto Rico are benefiting from biological control of invasive mole crickets. (author) [Spanish] Los grillotopos invasores no indigenas, Scapteriscus vicinus (Orthoptera: Gryllotalpidae) en el estado de Florida y S. didactylus ('changa') en Puerto Rico, estan siendo manejados por el nematodo entomopathogeno, Steinernema scapterisci (Rhabditida: Steinernematidae) y la avispa parasitica, Larra bicolor (Hymenoptera: Sphecidae). Las poblaciones de los grillotopo plagas han declinado un 95% en el norte central de la Florida desde que estos enemigos naturales especialistas fueron liberados y establecidos en los 80s. Consecuentemente, la produccion comercial del nematodo fue iniciada, casi 70 billones fueron aplicados en 34 condados de la Florida, y se realizo un monitoreo para evaluar su establecimiento, dispersion e impacto sobre los grillotopos. Los gillotopos infectados dispersaron los nematodos rapidamente, tanto que despues de 6 meses estos parasitos estaban presentes en la mayoria de los insectos atrapados en los pastos experimentales. Tres anos despues, las poblaciones de los grillotopos fueron reducidas a niveles aceptables y los campos de pasto 'bahia' se recuperaron. El nematodo fue liberado para la primera vez en Puerto Rico durante del 2001 y ha persistido; la avispa fue introducida al final de los 30s. La distribucion geografica de la avispa se esta extendiendo en la Florida y Puerto Rico por medio de la siembra de parcelas de Spermacoce verticillata, una flor silvestre indigena a Puerto Rico y distribuida ampliamente en el sur de la Florida. Los campos de pasto, las operaciones comerciales de cesped, los campos de golf, los paisajes y las fincas de hortalizas en la Florida y Puerto Rico se estan beneficiando del control biologico de los grillotopos invasores. (author)« less

Herbarium of the university of malaga (Spain): vascular plants collection.

PubMed

García-Sánchez, José; Cabezudo, Baltasar

2013-01-01

The herbarium of University of Málaga (MGC Herbarium) is formed by four biological collections. The vascular plants collection (MGC-Cormof) is the main collection of the herbarium. MGC-Cormof dataset aims to digitize and publish data associated with over 76.000 specimens deposited in the collection, of which 97.2% of the specimens are identified at species level. Since 2011, the University of Malaga's Central Research Service (SCAI) has been responsible for maintaining the herbariums and the dataset. The collection is growing continuously, with an annual intake of about 1.500 specimens. Nearly 96% of the collection is digitized, by Herbar v3.7.1 software (F. Pando et al. 1996-2011), making over 73.000 specimens accessible through the GBIF network (http://data.gbif.org/datasets/resource/8105/). At present, 247 families and 8.110 taxa, distributed in angiosperms (93.97%), ferns and fern allies (4.89%) and gymnosperms (1.14%), constitute the MGC-Cormof collection. The families and genera best represented in the collection are Compositae, Leguminosae, Gramineae, Labiatae, Caryophyllaceae, Teucrium, Silene, Asplenium, Linaria and Quercus. Most of the specimens are from the Western Mediterranean Region, fundamentally Southern Spain (Andalusia: 82% of specimens) and Northern Morocco (2.17%). Approximately, 63% of the specimens are georeferenced. The identification of the specimens in the collection has been carried out by the plant biology department at the University of Malaga and plus 40% of the specimens has been reviewed by experts. The MGC-Cormof dataset has been revised by DarwinTest v3.2 tool (Ortega-Maqueda and Pando 2008) before being published in GBIF. The data included in this database are important for conservation works, taxonomy, flora, cartography, phenology, palynology, among others. El Herbario de la Universidad de Málaga (Herbario MGC) está constituido por cuatro colecciones biológicas. La colección de plantas vasculares (MGC Cormof) es la colección principal del herbario. La base de datos MGC-Cormof tiene como objetivo la digitalización y publicación de los datos asociados con los más de 76.000 ejemplares depositados en la colección, de los cuales el 97,2% de las muestras se encuentran identificadas a nivel de especie. Desde 2011, los Servicios Centrales de Investigación (SCAI) de la Universidad de Málaga son responsables de mantener el herbario y sus respectivas bases de datos. Esta colección está en continuo crecimiento, con una incorporación anual de unos 1.500 ejemplares. Casi el 96% de la colección está digitalizada, a través del programa Herbar v3.7.1 (F. Pando et al. 1996-2011) por lo que más de 73.000 especímenes son accesibles a través de la red de GBIF (http://data.gbif.org/datasets/resource/8105/). Actualmente, la colección MGC-Cormof está constituida por 247 familias y 8.110 taxones, distribuidos en angiospermas (93,97%), helechos y plantas afines (4,89%) y gimnospermas (1,14%). Las familias y géneros mejor representados en la colección son Compositae, Leguminosae, Gramineae, Labiatae, Caryophyllaceae, Teucrium, Silene, Asplenium, Linaria y Quercus. La mayoría de los especímenes provienen de la región del Mediterráneo Occidental, fundamentalmente del sur de España (Andalucía: 82% de las muestras) y del norte de Marruecos (2,17%). Aproximadamente, el 63% de las muestras se encuentran georreferenciadas. La identificación de los ejemplares de la colección ha sido realizada por personal del departamento de biología vegetal de la Universidad de Málaga y además un 40% de los ejemplares ha sido revisado por especialistas. La base de datos MGC-Cormof ha sido revisada mediante la herramienta DarwinTest v3.2 (Ortega-Maqueda and Pando 2008) antes de ser publicada en GBIF. Los datos incluidos en esta base de datos son importantes para trabajos de conservación, taxonomía, flora, cartografía, fenología, palinología, entre otros.

Herbarium of the University of Malaga (Spain): Vascular Plants Collection

PubMed Central

García-Sánchez, José; Cabezudo, Baltasar

2013-01-01

Abstract The herbarium of University of Málaga (MGC Herbarium) is formed by four biological collections. The vascular plants collection (MGC-Cormof) is the main collection of the herbarium. MGC-Cormof dataset aims to digitize and publish data associated with over 76.000 specimens deposited in the collection, of which 97.2% of the specimens are identified at species level. Since 2011, the University of Malaga’s Central Research Service (SCAI) has been responsible for maintaining the herbariums and the dataset. The collection is growing continuously, with an annual intake of about 1.500 specimens. Nearly 96% of the collection is digitized, by Herbar v3.7.1 software (F. Pando et al. 1996–2011), making over 73.000 specimens accessible through the GBIF network (http://data.gbif.org/datasets/resource/8105/). At present, 247 families and 8.110 taxa, distributed in angiosperms (93.97%), ferns and fern allies (4.89%) and gymnosperms (1.14%), constitute the MGC-Cormof collection. The families and genera best represented in the collection are Compositae, Leguminosae, Gramineae, Labiatae, Caryophyllaceae, Teucrium, Silene, Asplenium, Linaria and Quercus. Most of the specimens are from the Western Mediterranean Region, fundamentally Southern Spain (Andalusia: 82% of specimens) and Northern Morocco (2.17%). Approximately, 63% of the specimens are georeferenced. The identification of the specimens in the collection has been carried out by the plant biology department at the University of Malaga and plus 40% of the specimens has been reviewed by experts. The MGC-Cormof dataset has been revised by DarwinTest v3.2 tool (Ortega-Maqueda and Pando 2008) before being published in GBIF. The data included in this database are important for conservation works, taxonomy, flora, cartography, phenology, palynology, among others. El Herbario de la Universidad de Málaga (Herbario MGC) está constituido por cuatro colecciones biológicas. La colección de plantas vasculares (MGC Cormof) es la colección principal del herbario. La base de datos MGC-Cormof tiene como objetivo la digitalización y publicación de los datos asociados con los más de 76.000 ejemplares depositados en la colección, de los cuales el 97,2% de las muestras se encuentran identificadas a nivel de especie. Desde 2011, los Servicios Centrales de Investigación (SCAI) de la Universidad de Málaga son responsables de mantener el herbario y sus respectivas bases de datos. Esta colección está en continuo crecimiento, con una incorporación anual de unos 1.500 ejemplares. Casi el 96% de la colección está digitalizada, a través del programa Herbar v3.7.1 (F. Pando et al. 1996–2011) por lo que más de 73.000 especímenes son accesibles a través de la red de GBIF (http://data.gbif.org/datasets/resource/8105/). Actualmente, la colección MGC-Cormof está constituida por 247 familias y 8.110 taxones, distribuidos en angiospermas (93,97%), helechos y plantas afines (4,89%) y gimnospermas (1,14%). Las familias y géneros mejor representados en la colección son Compositae, Leguminosae, Gramineae, Labiatae, Caryophyllaceae, Teucrium, Silene, Asplenium, Linaria y Quercus. La mayoría de los especímenes provienen de la región del Mediterráneo Occidental, fundamentalmente del sur de España (Andalucía: 82% de las muestras) y del norte de Marruecos (2,17%). Aproximadamente, el 63% de las muestras se encuentran georreferenciadas. La identificación de los ejemplares de la colección ha sido realizada por personal del departamento de biología vegetal de la Universidad de Málaga y además un 40% de los ejemplares ha sido revisado por especialistas. La base de datos MGC-Cormof ha sido revisada mediante la herramienta DarwinTest v3.2 (Ortega-Maqueda and Pando 2008) antes de ser publicada en GBIF. Los datos incluidos en esta base de datos son importantes para trabajos de conservación, taxonomía, flora, cartografía, fenología, palinología, entre otros. PMID:24194668

Node Ranking Tool - NoRT

DTIC Science & Technology

2018-03-23

Unclassified Unlimited Unclassified Unlimited Unclassified Unlimited 23 Ira S. Moskowitz (202) 404-7930 This paper gives a description of the Node Ranking Tool...Disease, Virus, Expectation, Pandemic, Close- ness, Graph, Degree, Spectrum. I. INTRODUCTION THis paper gives a description of the Node Ranking Tool...is very much dependent upon which centrality measure we use. Therefore, following [6] and [3], we use TOPSIS to evaluate our decisions about the

Do the Factors Affecting Academic Achievement Differ by the Socio-Economic Status or Sex of the Student? A Puerto Rican Secondary School Sample. Final Report.

ERIC Educational Resources Information Center

Nuttall, Ronald L.

Variables expected to be associated with academic achievement were examined in a sample (generally exceeding 2500) from eight secondary schools in Baymon Norte, Puerto Rico. Concern was whether variables associated with academic achievement differed by sex or by socioeconomic status (SES). Multivariate analyses of variance with three factors of…

"VAMONOS PAL NORTE" (LET'S GO NORTH), A SOCIAL PROFILE OF THE SPANISH SPEAKING MIGRATORY FARM LABORER.

ERIC Educational Resources Information Center

A YEARLY INCREASE OF MIGRATORY WORKERS TO OREGON RESULTED IN HIGHER WAGES IN THE AREA. IN 1957 THE SPANISH SPEAKING LABORERS IN OREGON NUMBERED 11,000 TO 12,000, 10 PERCENT OF WHOM WERE PERMANENT RESIDENTS. RECRUITMENT WAS CARRIED OUT BY CONTRACTORS. THEY OPERATED THROUGH SUBCONTRACTORS WHO IN TURN ACTED AS CONTACT MEN IN STRATEGIC LOCATIONS…

Diversidad de aves en agropaisajes en la region norte de Nicaragua

Treesearch

Wayne J. Arendt; Marvin Tórrez; Sergio Vílchez

2012-01-01

Avian diversity in agroscapes in Nicaragua’s north highlands. – Nicaragua’s highland forests are threatened by continual wood extraction and encroaching agriculture. Still, the effects of forest loss and fragmentation on avian communities remain little known. We used fixed-width point counts (distance sampling: 4843 detections during 86 h of observation) to...

Field Observations of Swash-Zone Dynamics on a Sea-Breeze Dominated Beach at the Yucatán Peninsula, México

NASA Astrophysics Data System (ADS)

Chardon-Maldonado, P.; Puleo, J. A.; Torres-Freyermuth, A.

2016-02-01

Sea breezes can modify the nearshore processes and alter beach morphology depending on the geographical location. Prior studies have shown that surf zone wave energy intensifies during strong sea-breeze conditions (wind speeds > 10 ms-1) and the impact on the coast can be similar to a small storm. However, few research efforts have investigated the coastal dynamics on sea-breeze dominated beaches (e.g., Masselink and Pattiaratchi, 1998, Mar. Geol.; Pattiaratchi et al., 1997, Cont. Shelf Res.) and, to the authors' knowledge, only one study has focused on swash-zone processes (Sonu et al., 1973, EOS). A field study was performed on a microtidal, low wave energy, sea-breeze dominated sandy beach in order to investigate the effects of local (sea breeze) and synoptic (storm) scale meteorological events on swash-zone dynamics. In-situ measurements of swash-zone hydrodynamics and sediment transport processes were collected from March 31st to April 12th, 2014 in Sisal, Yucatán located on the northern coast of the Yucatán Peninsula. Flow velocities and suspended sediment concentrations were measured concurrently, at multiple cross-shore and alongshore locations, using Vectrino-II profiling velocimeters and optical backscatter sensors, respectively. The high resolution data allowed the quantification of bed shear stress, turbulent dissipation rate, sediment loads and sediment flux during a mesoscale frontal system (cold-front passage referred to as an El Norte) and local sea-breeze cycles. Field observations showed that strong swash-zone bed shear stresses, turbulence intensity and sediment suspension occur during energetic conditions (i.e., El Norte event). On the other hand, despite milder energy conditions during the sea-breeze events, the alongshore component of bed-shear stresses and velocities can be significant owing to the high incidence wave angle associated with the sea-breeze system in the study area. The increased forcing in the swash zone induced sediment suspension, eroding the foreshore and causing accretion in the surf zone. The preliminary analysis demonstrates that strong sea-breeze events induce a significant alongshore swash-zone sediment transport that may be more important than that observed during an El Norte event.

The Ilocos Norte Communities against Rabies Exposure Elimination Project in the Philippines: Epidemiological and Economic Aspects.

PubMed

Valenzuela, Loida M; Jayme, Sarah I; Amparo, Anna Charinna B; Taylor, Louise H; Dela Cruz, Maria Pinky Z; Licuan, Dianne A; Gamal-Bitao, Rosebelle; Nel, Louis H

2017-01-01

As canine rabies control in Africa and Asia transitions from research-led proof-of-concept studies to government-led programs for elimination, experience and evidence of their impact and costs must be shared for the benefit of future programs. The Ilocos Norte Communities against Rabies Exposure project was implemented in April 2012 by the provincial veterinary and health offices and supported by many other partners. It delivered a comprehensive dog vaccination program and increased awareness of the need for postexposure prophylaxis (PEP), aiming to eliminate human and animal rabies cases from Ilocos Norte by 2015. Prior to the intervention, confirmed rabies cases in dogs were between 19 and 50 per year (2008-2011). The primary outcome of the project was a reduction in rabies cases in both dogs and humans to 0 in 2014 and 2015, which has subsequently been maintained. Animal bite consultations increased significantly during the project. Economic data for the dog vaccination and PEP components of the project were collated for two sites: Laoag City (an urban setting) and Dingras Municipality (a rural setting) between 2012 and 2014. The average programmatic cost of vaccinating each dog was $4.54 in Laoag City and $8.65 in Dingras, and costs fell as the project reached more dogs. The average costs of providing PEP were $69.72 per patient and $49.02 per patient for the two sites, respectively, again falling as the project reached more people. External donor contributions contributed less than 20% of dog vaccination costs and less than 1% of PEP costs. The project demonstrated that rabies elimination can be achieved in a short period of time, with concerted effort across multiple sectors. A lack of clear dog population estimates hampered interpretation of some aspects of the programme. From 2016, the provincial government has assumed complete responsibility for the programme and must now continue the vaccination and surveillance efforts. Although safeguards are in place, reintroduction from surrounding areas remains a threat, and vigilance must be maintained.

Preliminary Observations on the Changing Roles of Malaria Vectors in Southern Belize

DTIC Science & Technology

1993-01-01

darlingi (Diptera: Cu- licidae) de la Ceiba, Atlantida, Honduras. Thesis. Maestria en Entomologia. Universidad de Panama, Panama City, Panama. 456...Brown and C. Cordon-Rosales. 1992. Potential malaria vectors in northern Guatemala (Vectores potenciales de ma- laria in la region norte de Guatemala...Serra de Aqua in June 1946 (Linthicum 1988). We initiated a malaria vector research pro- gram in Belize in 1990 and conducted extensive larval

Genetic analyses, phenotypic adaptability and stability in sugarcane genotypes for commercial cultivation in Pernambuco.

PubMed

Dutra Filho, J A; Junior, T C; Simões Neto, D E

2015-10-05

In the present study, we assessed the agro-industrial performance of 22 sugarcane genotypes adaptable to edaphoclimatic conditions in production microregions in the State of Pernambuco, Brazil, and we recommended the commercial cultivation of select genotypes. The variables analyzed were as follows: sucrose percentage in cane juice, tonnage of saccharose per hectare (TPH), sugarcane tonnage per hectare (TCH), fiber, solid soluble contents, total recoverable sugar tonnage (ATR), and total recoverable sugar tonnage per hectare (ATR t/ha). A randomized block design with 4 repeats was used. Combined variance of the experiments, genetic parameter estimates, and environment stratification were analyzed. Phenotypic adaptability and stability were analyzed using the Annicchiarico and Wricke methods and analysis of variance. Genetic gain was estimated using the classic index and sum of ranks. Genotype selection was efficient for TPH, TCH, and ATR t/ha. Genotypes presented a great potential for improvement and a similar response pattern in Litoral Norte and Mata Sul microregions for TPH and TCH and Litoral Norte and Litoral Sul microregions for ATR t/ha. Genotypes SP78-4764, RB813804, and SP79-101 showed better productivity and phenotypic adaptability and stability, according to the Wricke and Annicchiarico methods. These genotypes can be recommended for cultivation in the sugarcane belt in the State of Pernambuco.

Inventorying and Monitoring of Tropical Dry Forests Tree Diversity in Jalisco, Mexico Using a Geographical Information System

Treesearch

Efren Hernandez-Alvarez; Dieter R. Pelz; Carlos Rodriguez Franco

2006-01-01

Tropical dry forests in Mexico are an outstanding natural resource, due to the large surface area they cover. This ecosystem can be found from Baja California Norte to Chiapas on the eastern coast of the country. On the Gulf of Mexico side it grows from Tamaulipas to Yucatan. This is an ecosystem that is home to a wide diversity of plants, which include 114 tree...

A new six-pored Amphisbaena (Squamata: Amphisbaenidae) from the coastal zone of northeast Brazil.

PubMed

Roberto, Igor Joventino; Brito, Lucas B M; Avila, Robson W

2014-01-06

We describe a new Amphisbaena from the Brazilian coastal zone at the municipalities of Guamaré and Macau, state of Rio Grande do Norte. The new species, Amphisbaena littoralis sp. nov., is characterized by six precloacal pores, 252-264 body annuli, 30-34 tail annuli with autotomy on the 6^th tail annuli, 20-22 dorsal and 21-24 ventral segments to the midbody annulus.

Translations on Narcotics and Dangerous Drugs No. 298

DTIC Science & Technology

1977-05-06

Cabecao was arrested, and detectives Dagomar Ruas Silva and Vitor Alves da Mota, both of whom were working at the time at the now-closed Vigilancia-Norte...Carvajal. It is believed that Mario Gil Ramirez , husband of Bercey Espinosa de Gil, and Miguel Alberto Lopez, who was recently arrested by F-2, are...clandestine laboratory in that city. Arrested were Segundo Gonzaga Granda, Ocamidoro Gonzaga Diaz and Epaminondas Ramirez Acosta. The traffickers were

Utilização Do Sensor Airdas (Airborne Infrared Disaster Assessment System) no monitoramento de desflorestamentos no norte do estado do mato grosso - Brasil

Treesearch

Geraldo José Lucatelli Dória de Araújo; João Antônio Raposo Pereira; Tânia Maria Vieira da Silva; Helvécio Mafra; James A. Brass; Robert N. Lockwood; Robert G. Higgins; Philip J. Riggan

2008-01-01

This study has as objective to assess AIRDAS (Airborne Infrared Disaster Assessment System) sensor for the monitoring of deforestation in the northern area of Mato Grosso State, between the latitudes 10° and 12° south and longitudes 54° and 56° west, within the area known as deforestation arch. The results show that the main advantage of...

[Density, size structure and reproductive activity of the pink conch Eustrombus gigas (Mesogastropoda: Strombidae) in Banco Chinchorro, Mexico].

PubMed

Cala, Yuself R; Navarrete, Alberto de Jesús; Ocaña, Frank A; Rivera, José Oliva

2013-12-01

The pink conch Eustrombus gigas is an important fisheries resource. At the regional level in the Caribbean, over-exploitation and habitat destruction have caused a decrease in the abundance of this resource. In order to provide necessary information for the species management in Mexico, this work aimed to analyze the total density, adult density, size structure and reproductive behavior of pink conch population at Banco Chinchorro during 2009-2010. Data from three seasons were obtained (rainy, dry and cold fronts periods) in three areas: Norte (North), Centro (Center) and Sur (South). The organisms were separated into two groups: (a) the criteria based upon legal harvest in Mexico: legal size conchs (siphonal length > 200 mm) and illegal size conchs (siphonal length < 200 mm), and (b) the criteria based upon sexual maturity using the 15 mm lip thickness standard: lip < 15 mm as juvenile conch and lip > or = 15 mm as adult conch. Copulation, spawning, egg masses and aggregations were evaluated as reproductive evidences. The highest total density was observed during the dry season with 384ind./ha, and the lowest during the rainy season with 127ind./ha. The highest density was reported at Sur (385ind./ha) and the lowest at Norte (198ind./ ha). The highest adult density was observed during the rainy season (8.33ind./ha), and the lowest occurred in the dry season (6.1 ind./ha). Adult density values were 5.55, 7.05 and 8.33ind./ha for Centro, Sur and Norte areas, respectively. Adult densities were lower than the threshold needed for reproduction, and 42% of the population may be vulnerable to fishing, as they had the minimum size for catch (Lsi 200 mm). Furthermore, only 2.2% of the population reached a Gl > 15 mm as sexual maturity indicator. During the study period, only six evidences of reproductive activity were observed. The smaller densities reported at Banco Chinchorro may cause reproduction events to be almost absent which in turn is sufficient evidence to show that the Allee Effect is acting on the queen conch population and there is an urgent need of fishery closure. Three important points were proposed for management of queen conch at Banco Chinchorro: total closure of fishing, systematic assessment of the conch population and the implementation of conch fishing refuge.

Armor in Vietnam

DTIC Science & Technology

1976-05-01

battles a-Riuot the insurgent enemy, especially with armor. French contingents were present in Tndo Chinh P-w early as 1852, but it was not until 1884...committed to Vietnam were straight infantry. These troons er•A tran -norted in hn4±{ copters and usually airlifted to the battle zone; however, once...0STAINf0 FROM VKTNAM NATIONAL MAP SERVICE (NOS) PHU-YEN OCTOBER 19665 OARLAC ......... KKAN1+ HOA QLWA- DUC TUYEN- DUC PHUOC- NINH_ C;ry OF -10 T CAM RANK TAY

Neuronal Function in Male Sprague Dawley Rats During Normal Ageing.

PubMed

Idowu, A J; Olatunji-Bello, I I; Olagunju, J A

2017-03-06

During normal ageing, there are physiological changes especially in high energy demanding tissues including the brain and skeletal muscles. Ageing may disrupt homeostasis and allow tissue vulnerability to disease. To establish an appropriate animal model which is readily available and will be useful to test therapeutic strategies during normal ageing, we applied behavioral approaches to study age-related changes in memory and motor function as a basis for neuronal function in ageing in male Sprague Dawley rats. 3 months, n=5; 6 months, n=5 and 18 months, n=5 male Sprague Dawley Rats were tested using the Novel Object Recognition Task (NORT) and the Elevated plus Maze (EPM) Test. Data was analyzed by ANOVA and the Newman-Keuls post hoc test. The results showed an age-related gradual decline in exploratory behavior and locomotor activity with increasing age in 3 months, 6 months and 18 months old rats, although the values were not statistically significant, but grooming activity significantly increased with increasing age. Importantly, we established a novel finding that the minimum distance from the novel object was statistically significant between 3 months and 18 months old rats and this may be an index for age-related memory impairment in the NORT. Altogether, we conclude that the male Sprague Dawley rat show age-related changes in neuronal function and may be a useful model for carrying out investigations into the mechanisms involved in normal ageing.

Termites as bioindicators of habitat quality in the caatinga, Brazil: is there agreement between structural habitat variables and the sampled assemblages?

PubMed

Alves, W de F; Mota, A S; Lima, R A A de; Bellezoni, R; Vasconcellos, A

2011-01-01

The composition of termite assemblages was analyzed in three caatinga sites of the Estação Ecológica do Seridó, located in the municipality of Serra Negra do Norte, in the state of Rio Grande do Norte, Brazil. These sites have been subjected to selective logging, and cleared for pasture and farming. A standardized sampling protocol for termite assemblages (30h/person/site) was conducted between September 2007 and February 2009. At each site we measured environmental variables, such as soil pH and organic matter, necromass stock, vegetation height, stem diameter at ankle height (DAH) and the largest and the smallest crown width. Ten species of termites, belonging to eight genera and three families, were found at the three experimental sites. Four feeding groups were sampled: wood-feeders, soil-feeders, wood-soil interface feeders and leaf-feeders. The wood-feeders were dominant in number of species and number of encounters at all sites. In general, the sites were not significantly different in relation to the environmental variables measured. The same pattern was observed for termite assemblages, where no significant differences in species richness, relative abundance and taxonomic and functional composition were observed between the three sites. The agreement between composition of assemblages and environmental variables reinforces the potential of termites as biological indicators of habitat quality.

Epidemiologic Profile of Patients Transplanted With Hematopoietic Stem Cells in a Reference Service in the State of Rio Grande do Norte, Brazil.

PubMed

Campos de Azevedo, I; Ferreira Júnior, M A; Pereira de Aquino, L A; de Oliveira, A A; Cruz, G K P; de Queiroz Cardoso, A I; Ivo, M L; Santos, V E P

2018-04-01

Hematopoietic stem cell transplantation (HSCT) consists of the intravenous infusion of healthy hematopoietic stem cells to restore the medullary and immunologic function of patients affected by a series of hematologic, oncologic, immunologic, malignant and nonmalignant inherited or acquired diseases, with the possibility of cure or increase of disease-free survival. To characterize the epidemiologic profile and the cases of death of patients who underwent HSCT. This is a cohort quantitative study, nested with a retrospective, descriptive, and analytical study of a hospital-based cohort that included the patients who underwent HSCT at a referral service in the state of Rio Grande do Norte, a region of northeastern Brazil. There was a slight male prevalence (52.94%), the age of the patients ranged from 2 to 73 years old, 18.38% were brown, 47.06% were married, 15.07% were students, 78.31% had a diagnosis of multiple myeloma, 93.38% developed gastrointestinal toxicities, all patients received chemotherapeutic treatment, 54.78% had allogeneic HSCT, and the cause of the most recorded deaths was septic shock (48.19%). This study showed relevant scientific evidence on the clinical and epidemiologic profile of patients who underwent HSCT. In general, sociodemographic data are similar to national and international research results. Copyright © 2018 Elsevier Inc. All rights reserved.

Effect of 1.8 GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice

PubMed Central

Wang, Kai; Lu, Jun-Mei; Xing, Zhen-He; Zhao, Qian-Ru; Hu, Lin-Qi; Xue, Lei; Zhang, Jie; Mei, Yan-Ai

2017-01-01

Mounting evidence suggests that exposure to radiofrequency electromagnetic radiation (RF-EMR) can influence learning and memory in rodents. In this study, we examined the effects of single exposure to 1.8 GHz RF-EMR for 30 min on subsequent recognition memory in mice, using the novel object recognition task (NORT). RF-EMR exposure at an intensity of >2.2 W/kg specific absorption rate (SAR) power density induced a significant density-dependent increase in NORT index with no corresponding changes in spontaneous locomotor activity. RF-EMR exposure increased dendritic-spine density and length in hippocampal and prefrontal cortical neurons, as shown by Golgi staining. Whole-cell recordings in acute hippocampal and medial prefrontal cortical slices showed that RF-EMR exposure significantly altered the resting membrane potential and action potential frequency, and reduced the action potential half-width, threshold, and onset delay in pyramidal neurons. These results demonstrate that exposure to 1.8 GHz RF-EMR for 30 min can significantly increase recognition memory in mice, and can change dendritic-spine morphology and neuronal excitability in the hippocampus and prefrontal cortex. The SAR in this study (3.3 W/kg) was outside the range encountered in normal daily life, and its relevance as a potential therapeutic approach for disorders associated with recognition memory deficits remains to be clarified. PMID:28303965

Epidemiological and serological profiles of ocular toxoplasmosis in the municipality of Natal, northeastern Brazil.

PubMed

Mendes, Norma H D; Oliveira, Claudio B S; Garcia, Carlos A; Holanda, Cecília M X C; Andrade-Neto, Valter F

2014-10-01

Toxoplasma gondii is the main culprit in most cases of infectious uveitis, in both acute and recurrent cases of congenital toxoplasmosis and acquired infections. The ocular toxoplasmosis was evaluated in patients at the the reference unit in ophthalmology, in Rio Grande do Norte State, determining the risk factors, and the epidemic, serological and clinical profiles. The production of IgM and IgG antibodies to T. gondii was evaluated by microparticle enzyme immunoassay (MEIA). The same patients diagnosed with fundoscopic alterations have been subjected to the fundus photography procedure. Of the 116 patients with positive serology, 66 patients had bilateral ocular damage and 38 patients showed a higher frequency of lesions of type I. The epidemiological investigation showed that direct contact with cats, the consumption of raw or undercooked meat and direct contact with soil are factors not related to ocular toxoplasmosis development. The characterization of the sample was significant for patients aged 31-40 years. Ocular toxoplasmosis is widely distributed in Natal and other cities in Rio Grande do Norte state, with special relevance for bilateral lesions in 56.9% of the patients assessed, the most frequent being type I with intraocular disposition in the macula. © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

A Numerical Study of the Plata River Plume Along the Southeastern South American Continental Shelf

DTIC Science & Technology

2005-01-01

Aires Depto. de Oceanografia, Servicio de Hidrografia Naval and Depto. CiEncias de la Atm6sfera y los Ocdanos, Buenos Aires, Argentina ABSTRACT The...descarrega no oceano Aguas de uma bacia de drenagem que cobre uma ampla Area da Amdrica do Sul. Sua pluma extende-se ao longo do norte da Argentina ...Instituto Nacional de Investigaci6n y Orlanski, I. 1976. A simple boundary condition for Desarrollo Pesquero, 109pp. unbounded hyperbolic flows. J

Balik Terrorism: The Return of the Abu Sayyaf

DTIC Science & Technology

2005-09-01

Hudaibiyah," to work with the ASG. The JI operative, Rohmat (aka Zaki), had been a JI trainer at Camp Hudaibiyah in Camp Abu Bakar in 2000, and then in...brothers traveled to Camp Abu Bakar in August 1999 to meet with MILF leaders; and in December 2001, Santos underwent military and explosives training...More Davao Bombers Nabbed in Davao Norte," Sun-Star, November 19, 2004. 68. Camp Hudaibiyah was the portion of the MILF base, Camp Abu Bakar es

Education, ethics, and solidarity in international cooperation.

PubMed

Castro, Janete Lima de; Vilar, Rosana Lucia Alves de; Germano, Raimunda Medeiros

2015-01-01

The article analyzes an experience in technical cooperation between Brazil and Andean countries in the form of the International Course in the Management of Human Resource Policies in Health. This exploratory documental study encompassed a number of Latin American countries whose institutions of higher education had partnerships with the Federal University of Rio Grande do Norte, mediated by the Pan American Health Organization Representation in Brazil. The course experience shows that fundamental values like ethics and solidarity are determinant to the success of technical cooperation processes.

JPRS Report, Science & Technology, Europe & Latin America, Brazil: Selections from the 1987 Federal S&T Budget.

DTIC Science & Technology

1988-02-24

of Goias 67 . Federal University of the State of Rio de Janeiro 68 . Federal University of Juiz de Fora 68 . Federal University of Minas Gerais...Federal University of Rio Grande do Norte 72 . Federal University of Rio Grande do Sul • 72 . Federal University of Rio de Janeiro 73...University of Rio de Janeiro 75 . School of Agrarian Sciences of Para 76 . School of Medicine of the Minas Triangle 77 . Federal Technological Education

Hydrochemical tracers in the middle Rio Grande Basin, USA: 1. Conceptualization of groundwater flow

NASA Astrophysics Data System (ADS)

Plummer, L. Niel; Bexfield, Laura M.; Anderholm, Scott K.; Sanford, Ward E.; Busenberg, Eurybiades

Chemical and isotopic data for groundwater from throughout the Middle Rio Grande Basin, central New Mexico, USA, were used to identify and map groundwater flow from 12 sources of water to the basin, evaluate radiocarbon ages, and refine the conceptual model of the Santa Fe Group aquifer system. Hydrochemical zones, representing groundwater flow over thousands to tens of thousands of years, can be traced over large distances through the primarily siliciclastic aquifer system. The locations of the hydrochemical zones mostly reflect the ``modern'' predevelopment hydraulic-head distribution, but are inconsistent with a trough in predevelopment water levels in the west-central part of the basin, indicating that this trough is a transient rather than a long-term feature of the aquifer system. Radiocarbon ages adjusted for geochemical reactions, mixing, and evapotranspiration/dilution processes in the aquifer system were nearly identical to the unadjusted radiocarbon ages, and ranged from modern to more than 30 ka. Age gradients from piezometer nests ranged from 0.1 to 2 year cm-1 and indicate a recharge rate of about 3 cm year-1 for recharge along the eastern mountain front and infiltration from the Rio Grande near Albuquerque. There has been appreciably less recharge along the eastern mountain front north and south of Albuquerque. Des données sur les éléments chimiques et les isotopes présents dans l'eau souterraine prélevée à divers endroits dans le bassin moyen du Rio Grande, au centre du Nouveau-Mexique (É-U), ont permis de déterminer l'existence et l'étendue de douze sources d'eau régionales dans le bassin, d'évaluer les âges radiocarbones et de raffiner le modèle conceptuel du système aquifère du groupe de Santa Fe. Des zones hydro-chimiques qui représentent l'écoulement de l'eau souterraine depuis des dizaines de milliers d'années peuvent être suivies sur de longues distances à travers l'aquifère principalement siliclastique. La position des zones hydro-chimiques reflète principalement la distribution moderne des charges hydrauliques mais est incohérente avec une dépression dans le niveau d'eau dans la partie centre-ouest du bassin, ce qui indique que cette dépression est un élément transitoire du système aquifère plutôt qu'un élément à long terme. Les âges radiocarbones ajustés aux réactions géochimiques et aux processus de mélange et d'évapotranspiration/dilution qui ont lieu dans l'aquifère sont presque identiques aux âges non ajustés et varient de la période moderne jusqu'à 30 ka. Les gradients d'âge établis à partir des nids de piézomètres s'étendent de 0.1 à 2 a cm-1 et suggèrent un taux de recharge d'environ 3 cm a-1 le long du front des montagnes à l'est et pour l'infiltration provenant du Rio Grande près d'Albuquerque. Il y a eu substantiellement moins de recharge le long du front des montagnes à l'est, au nord et au sud d'Albuquerque. Se utilizaron datos químicos e isotópicos de agua subterránea a lo largo de la cuenca central del río Grande, Nuevo México, EEUU, para identificar y mapear el flujo de agua subterránea de 12 fuentes de agua a la cuenca para evaluar edades por medio de radio carbon y para refinar el modelo conceptual del sistema acuífero del Grupo Santa Fé. Se puede establecer zonas hidrotérmicas que representan el flujo de agua subterránea a lo largo de miles a miles de decenas de años en grandes distancias a través del sistema acuífero principalmente siliclástico. Las ubicaciones de las zonas hidroquímicas mayormente reflejan la distribucion de la cabeza hidráulica pre-desarollo moderna pero son inconsistentes con una depresión en los niveles de agua pre-desarollo en la zona central oeste de la cuenca. Esto indica que esta depresión es un rasgo transitorio y no un rasgo de largo plazo del sistema acuífero. Las edades de radio carbon ajustadas para los procesos de reaciones geoquímicas, de mezclado y de evapotranspiración-dilución son casi idénticas a los edades de radio carbon no ajustadas oscilan en un rango desde la modernidad a 30 mil años. Las gradientes de edad de nidos de piezometros van de 0.1 a 2 años cm-1 e indican un sitio de recarga de aproximadamente 3 cm/yr para la recarga a lo largo del frente montañoso oriental e infiltración del río Grande cerca de Albuquerque. Se aprecia una recarga menor a lo largo del frente oriental de montañas al norte y al sur de Albuquerque.

Distribution and prevalence of vector-borne diseases in California chipmunks (Tamias spp.)

PubMed Central

Roy, Austin N.; Martin, Amanda; Sholty, Kathleen E.; Stephenson, Nicole; Foley, Janet E.

2017-01-01

California, with 13 chipmunk (Tamias) species, has more than any other state or country, occupying habitats ranging from chaparral to the high peaks of the Sierra Nevada. Chipmunks host zoonotic pathogens including Yersinia pestis, Anaplasma phagocytophilum, relapsing fever (RF) Borrelia spp., Borrelia burgdorferi, and spotted fever group (SFG) Rickettsia species. Chipmunk species are often not differentiated by public health workers, yet different species utilize different ecological niches and may have intrinsically different capacities for maintaining vector-borne pathogens and infecting vectors. We surveyed over 700 individuals from nine species of chipmunks throughout California for exposure to and infection by Y. pestis, A. phagocytophilum, RF Borrelia spp., Borrelia burgdorferi, and SFG Rickettsia species. DNA of all five pathogens was found and all chipmunks except Merriam’s chipmunk (T. merriami) were PCR-positive for at least one of the pathogens. Anaplasma phagocytophilum was most common (40.0%, 2/5) in Sonoma chipmunks (T. sonomae) from Marin county and B. burgdorferi most common (37.5%, 27/72) in redwood chipmunks (T. ochrogenys) from Mendocino county. RF Borrelia spp. was detected in 2% (6/297) of redwood chipmunks in Mendocino county and 10% (1/10) of both least (T. minimus) and lodgepole (T. speciosus) chipmunks in the western Sierra. Exposure to SFG Rickettsia spp. was found in the Northern Coastal region (Del Norte, Humboldt and Mendocino counties) and in the northern and western Sierra in several species of chipmunks. Y. pestis infection was found only in the western Sierra—in a yellow-pine (T. amoenus) and a long-eared (T. quadrimaculatus) chipmunk. Though more data are needed to thoroughly understand the roles that different chipmunk species play in disease transmission, our findings suggest that some chipmunk species may be more important to the maintenance of vector-borne diseases than others within each geographic area. PMID:29232397

A GIS Representation of 1964 Tsunami Damage in Crescent City, California

NASA Astrophysics Data System (ADS)

Velasco Campos, C. J.; Dengler, L. A.

2013-12-01

The March 1964 Alaska tsunami caused major damage in Alaska and also impacted the west coast of North America. Crescent City, California, 3000 km away from the source region, suffered the greatest damage outside Alaska. Twenty-nine blocks of the downtown and harbor areas were inundated and nearly 300 homes and businesses damaged or destroyed. In the aftermath of the tsunami, numerous maps, reports and photographs of the impacts in Crescent City were released, some by engineers and scientists, and much by individuals and the popular press. The Del Norte Historical Society has a large amount of archival material (photographs and eye witness accounts) from the tsunami, much of which has never been thoroughly examined or correlated with other reports. In this study, we assemble all of the available information from these disparate sources into a GIS framework in order to examine the 1964 Crescent City damage in a systematic way and provide a quantitative framework for others who are modeling tsunami impacts. Using ArcGIS 10, old aerial photos, tsunami inundation maps, and photographs were georeferenced to produce GIS layers of 'before and after' Crescent City. Hyperlinks were created to connect photos with their locations in present day. We reference damage to a layer showing Magoon's 1968 map of inundation depth and extent. Structural damage falls into four main groupings: structures floated off of foundations, damage by impact from debris, pressure differences from water infilling structures, and fire. 15 structures were moved off of foundations, all in the direction of the outgoing flow. We also create layers of the structures of the modern city and the predicted tsunami run-up from a Cascadia event. Magoon, Orville T., 1966, Structural Damage by Tsunamis, Proceedings, American Society Civil Engineers, Specialty Conference on Coastal Engineering, Santa Barbara (California), Oct. 1965, pp. 35-68

Desertification, salinization, and biotic homogenization in a dryland river ecosystem

USGS Publications Warehouse

Miyazono, S.; Patino, Reynaldo; Taylor, C.M.

2015-01-01

This study determined long-term changes in fish assemblages, river discharge, salinity, and local precipitation, and examined hydrological drivers of biotic homogenization in a dryland river ecosystem, the Trans-Pecos region of the Rio Grande/Rio Bravo del Norte (USA/Mexico). Historical (1977-1989) and current (2010-2011) fish assemblages were analyzed by rarefaction analysis (species richness), nonmetric multidimensional scaling (composition/variability), multiresponse permutation procedures (composition), and paired t-test (variability). Trends in hydrological conditions (1970s-2010s) were examined by Kendall tau and quantile regression, and associations between streamfiow and specific conductance (salinity) by generalized linear models. Since the 1970s, species richness and variability of fish assemblages decreased in the Rio Grande below the confluence with the Rio Conchos (Mexico), a major tributary, but not above it. There was increased representation of lower-flow/higher-salinity tolerant species, thus making fish communities below the confluence taxonomically and functionally more homogeneous to those above it. Unlike findings elsewhere, this biotic homogenization was due primarily to changes in the relative abundances of native species. While Rio Conchos discharge was > 2-fold higher than Rio Grande discharge above their confluence, Rio Conchos discharge decreased during the study period causing Rio Grande discharge below the confluence to also decrease. Rio Conchos salinity is lower than Rio Grande salinity above their confluence and, as Rio Conchos discharge decreased, it caused Rio Grande salinity below the confluence to increase (reduced dilution). Trends in discharge did not correspond to trends in precipitation except at extreme-high (90th quantile) levels. In conclusion, decreasing discharge from the Rio Conchos has led to decreasing flow and increasing salinity in the Rio Grande below the confluence. This spatially uneven desertification and salinization of the Rio Grande has in turn led to a region-wide homogenization of hydrological conditions and of taxonomic and functional attributes of fish assemblages.

Desertification, salinization, and biotic homogenization in a dryland river ecosystem.

PubMed

Miyazono, Seiji; Patiño, Reynaldo; Taylor, Christopher M

2015-04-01

This study determined long-term changes in fish assemblages, river discharge, salinity, and local precipitation, and examined hydrological drivers of biotic homogenization in a dryland river ecosystem, the Trans-Pecos region of the Rio Grande/Rio Bravo del Norte (USA/Mexico). Historical (1977-1989) and current (2010-2011) fish assemblages were analyzed by rarefaction analysis (species richness), nonmetric multidimensional scaling (composition/variability), multiresponse permutation procedures (composition), and paired t-test (variability). Trends in hydrological conditions (1970s-2010s) were examined by Kendall tau and quantile regression, and associations between streamflow and specific conductance (salinity) by generalized linear models. Since the 1970s, species richness and variability of fish assemblages decreased in the Rio Grande below the confluence with the Rio Conchos (Mexico), a major tributary, but not above it. There was increased representation of lower-flow/higher-salinity tolerant species, thus making fish communities below the confluence taxonomically and functionally more homogeneous to those above it. Unlike findings elsewhere, this biotic homogenization was due primarily to changes in the relative abundances of native species. While Rio Conchos discharge was>2-fold higher than Rio Grande discharge above their confluence, Rio Conchos discharge decreased during the study period causing Rio Grande discharge below the confluence to also decrease. Rio Conchos salinity is lower than Rio Grande salinity above their confluence and, as Rio Conchos discharge decreased, it caused Rio Grande salinity below the confluence to increase (reduced dilution). Trends in discharge did not correspond to trends in precipitation except at extreme-high (90th quantile) levels. In conclusion, decreasing discharge from the Rio Conchos has led to decreasing flow and increasing salinity in the Rio Grande below the confluence. This spatially uneven desertification and salinization of the Rio Grande has in turn led to a region-wide homogenization of hydrological conditions and of taxonomic and functional attributes of fish assemblages. Copyright © 2015 Elsevier B.V. All rights reserved.

Occurrence of anti-Toxoplasma gondii antibodies in meat and dairy goat herds in Rio Grande do Norte, Brazil.

PubMed

Medeiros, Andréa Dantas de; Andrade, Milena de Medeiros Clementino; Vítor, Ricardo Wagner de Almeida; Andrade-Neto, Valter Ferreira de

2014-01-01

Toxoplasmosis is caused by Toxoplasma gondii, which is the main causative agent of abortion in small ruminants. Goats are among the animals that are most susceptible to this protozoon, and the disease that it causes leads to significant economic losses and has implications for public health, since presence of the parasite in products of goat origin is one of the main sources of human infection. Because of the significant economic impact, there is an urgent need to study the prevalence of T. gondii infection among goats in Sertão do Cabugi, which is the largest goat-producing region in Rio Grande do Norte. In the present study, the ELISA assay was used to test 244 serum samples from nine farms, located in four different municipalities in the Sertão do Cabugi region, which is an important goat-rearing region. The results showed that the prevalence of anti-T. gondii antibodies was 47.1% and that there was a significant association between positivity and the variables of age (≥ 34 months), location (Lajes, Angicos and Afonso Bezerra) and farm (all the farms). The avidity test was applied to all the 115 ELISA-positive samples to distinguish between acute and chronic infection. One hundred and three samples (89.6%) displayed high-avidity antibodies, thus indicating that most of the animals presented chronic infection, with a consequent great impact on the development of the goat production system and a risk to human health.

Ichthyofauna of Ceará-Mirim River basin, Rio Grande do Norte State, northeastern Brazil

PubMed Central

da Costa, Nathalia Kaluana Rodrigues; de Paiva, Roney Emanuel Costa; da Silva, Márcio Joaquim; Ramos, Telton Pedro Anselmo; Lima, Sergio Maia Queiroz

2017-01-01

Abstract Ichthyological studies in coastal basins of the Mid-Northeastern Caatinga ecoregion were first conducted in the early 20th century, including collections from the Ceará-Mirim River basin, in northeastern Brazil. Besides a few systematics and ecological studies, the knowledge on fishes from this watershed is still considered partial and restricted to the freshwater portion. Thus, the objective of this paper was to conduct a comprehensive ichthyological survey of the entire Ceará-Mirim River basin, from the headwaters to the estuarine area. Fish surveys were conducted from 2011 to 2016 using varied fishing gear, resulting in the record of 63 native species (24 freshwater, 15 estuarine, and 24 marine species) and two introduced species. Four species are putatively endemic to the ecoregion, and 48 consist of new records for the basin. According to the Brazilian’s threatened fish list, three species are currently classified as ‘vulnerable’ (Megalops atlanticus, Hippocampus reidi and Mycteroperca bonaci), four as ‘near threatened’ (Kryptolebias hermaphroditus, Dormitator maculatus, Lutjanus sygnagris and L. jocu) and three as ‘data deficient’ (Cheirodon jaguaribensis, Mugil curema and Sphoeroides testudineus). The Ceará-Mirim River basin does not have any protected areas and has been suffering multiple anthropogenic impacts, however the "Centro Tecnológico de Aquicultura" (Aquaculture Technological Center) of the Universidade Federal do Rio Grande do Norte (CTA/UFRN) at the lower portion of the basin may help in the conservation of the estuarine and estuarine fish species. PMID:29302231

Spatial and temporal variation in artisanal catches of dolphinfish Coryphaena hippurus off north-eastern Brazil.

PubMed

Nóbrega, M F; Kinas, P G; Lessa, R; Ferrandis, E

2015-02-01

The sampling of fish from the artisanal fleet operating with surface lines off north-eastern Brazil was carried out between 1998 and 2000. Generalized linear models (GLMs) were used to standardize mean abundance indices using catch and fishing effort data on dolphinfish Coryphaena hippurus and to identify abundance trends in time and space, using 1215 surface line deployments. A standard relative abundance index (catch per unit effort, CPUE) was estimated for the most frequent vessels used in the sets, employing factors and coefficients generated in the GLMs. According to the models, C. hippurus catches are affected by the operating characteristics and power of different fishing vessels. These differences highlight the need for standardization of catch and effort data for artisanal fisheries. The highest mean abundance values for C. hippurus were off the state of Rio Grande do Norte, with an increasing tendency in areas with greater depths and more distant from the coast, reaching maximal values in areas whose depths range from 200 to 500 m. The highest mean abundance values occurred between April and June. The higher estimated abundance of C. hippurus in this period off the state of Rio Grande do Norte and within the 200-500 m depth range may be related to a migration pattern of food sources, as its main prey, the flying fish Hirundichthys affinis, uses floating algae as refuge and to deposit its pelagic eggs. © 2015 The Fisheries Society of the British Isles.

Molecular docking and antiamnesic effects of nepitrin isolated from Rosmarinus officinalis on scopolamine-induced memory impairment in mice.

PubMed

Karim, Nasiara; Khan, Imran; Abdelhalim, Abeer; Abdel-Halim, Heba; Hanrahan, Jane R

2017-12-01

Rosmarinus officinalis has long been known as the herb of remembrance. The present study was undertaken to investigate the anti-amnesic effects of nepitrin isolated from Rosmarinus officinalis using in-vivo models of Y-maze and novel object recognition test (NORT) along with in vitro antioxidant and acetylcholinesterase (AChE) and buterylcholinesterase (BuChE) inhibition potential. Nepitrin showed a concentration dependent inhibition of AChE and BuChE enzymes with IC 50 values of 65 and 72μg/mL, respectively and antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) with IC 50 values 270 and 210μg/mL, respectively. In mice, nepitrin reversed the amnesia induced by scopolamine as indicated by a dose-dependent increase in spontaneous alternation performance in the Y-maze task (p <0.05 versus scopolamine) and increase in the discrimination index in the novel object recognition test (NORT) comparable to the standard drug donepezil 2mg/kg. Molecular docking studies were performed and the GlideScore of nepitrin was consistent with its experimental AChE inhibitory activities. Nepitrin occupied the same binding site forming similar interactions to those formed by donepezil in the crystal structure. Thus, nepitrin could provide a lead for the development of therapeutic agent useful in cognition and memory disorders such as Alzheimer's disease. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Evaluation of surrogate markers for human immunodeficiency virus infection among blood donors at the blood bank of "Hospital Universitário Regional Norte do Paraná", Londrina, PR, Brazil.

PubMed

Reiche, Edna Maria Vissoci; Vogler, Ingridt Hildegard; Morimoto, Helena Kaminami; Bortoliero, André Luis; Matsuo, Tiemi; Yuahasi, Kátia Kioko; Cancian, Sanderson Júnior; Koguichi, Roberto Setsuo

2003-01-01

This study evaluated the usefulness of the anti-HBc, hepatitis C virus antibodies (anti-HCV), human T cell lymphotropic virus I and II antibodies (anti-HTLV I/II), serologic tests for syphilis, and surface antigen of hepatitis B virus (HBsAg) as surrogate markers for the risk for HIV infection in 80,284 serum samples from blood donors from the Blood Bank of "Hospital Universitário Regional Norte do Paraná", Londrina, Paraná State, Brazil, analyzed from July 1994 to April 2001. Among 39 blood donors with positive serology for HIV, 12 (30.8%) were anti-HBc positive, 10 (25.6%) for anti-HCV, 1 (2.6%) for anti-HTLV I/I, 1 (2.6%) was positive for syphilis, and 1 (2.6%) for HBsAg. Among the donors with negative serology for HIV, these markers were detected in 8,407 (10.5%), 441 (0.5%), 189 (0.2%), 464 (0.6%), and 473 (0.6%) samples, respectively. The difference was statistically significant (p < 0.001) for anti-HBc and anti-HCV. Although the predictive positive values for these surrogate markers were low for HIV infection, the results confirmed the anti-HBc and anti-HCV as useful surrogate markers for HIV infection thus reinforcing the maintenance of them in the screening for blood donors contributing to the prevention of the small number of cases in which HIV is still transmitted by transfusion.

Negligent and intentional fires in Portugal: the role of human and biophysical drivers on the spatial distribution

NASA Astrophysics Data System (ADS)

Parente, Joana; Pereira, Mário; Amraoui, Malik; Tedim, Fantina

2017-04-01

The European Mediterranean countries, such as Portugal, Spain, France, Italy and Greece, have the higher incidence of fire. Of these countries, Portugal present the highest average number of fires (NF) and one of the highest burnt area (BA), in spite of its relatively smaller land area. The study period is focused in the recent years of 2012 - 2014, when a total of 59 257 fires were recorded and the fire cause is known for more than 50% of the fire records. All fires with known causes were then classified into intentional (40% of the total number of fires) and negligent (60%), leading to a total of 45% of fires related with human factors and activities. Taking into account these values the authors believe it's necessary to better understand the fire regime of this type of fires for a better fire prevention, firefighting and crisis management. Accordingly, the use of statistical analysis and GIS techniques were used to assess the spatial distribution of the human caused fires in each of the NUTS (Nomenclature of Territorial Units for Statistics level I, which divides Portugal in 5 basic economic regions, namely Norte, Centro, Area Metropolitana de Lisboa, Alentejo, and Algarve. The number of fires distribution increases with latitude, making north of Portugal the region with the highest number of fires. The analysis will also aims to assess the role of the most important human and biophysical drivers of the spatial distribution, namely the population density, land use land cover (LULC), distance to communication routes (roads and railways) and topographic variables (altitude, slope). The results show that: a) population density is highly and positively correlated with the agglomeration of fire ignitions, but doesn't imply highest burned area; b) burnt area increase with the distance to roads and altitude; and, c) 58% of the fires occurred on agriculture areas and 33% of fires occurred in forest and scrubs areas. Acknowledgements: This work was supported by: (i) the project Interact - Integrative Research in Environment,Agro-Chain and Technology, NORTE-01-0145-FEDER-000017, research line BEST, cofinanced by FEDER/NORTE 2020; (ii) the FIREXTR project, PTDC/ATP¬GEO/0462/2014; and, (iii) European Investment Funds by FEDER/COMPETE/POCI-Operacional Competitiveness and Internacionalization Programme, under Project POCI-01-0145-FEDER-006958 and National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UID/AGR/04033. We are especially grateful to ICNF for providing the fire data.

The Challenge of Violent Drug-Trafficking Organizations: An Assessment of Mexican Security Based on Existing RAND Research on Urban Unrest, Insurgency, and Defense-Sector Reform

DTIC Science & Technology

2011-01-01

Bad Factors Outcome Afghanistan (post-Soviet) 0 10 –10 Loss Somalia 1 10 –9 Loss Chechnya I 2 10 –8 Loss Rwanda 2 10 –8 Loss Zaire (anti-Mobutu) 0...most of Baha California (Norte/Sur), Sonora, Chihuahua, Durango, Sinaloa, Nayarit, Jalisco, Colima, Quintana Roo, Yucatan, Campeche, Zacatecas...Sources of Success in Counterinsurgency and Victory Has a Thousand Fathers: Detailed Counterinsurgency Case Stud- ies . For that study, the research

[Migration to the northern frontier of Mexico and its relationship with the regional labor market].

PubMed

Anguiano Tellez, M E

1998-01-01

"This document tries to show the close relationship between the recent population growth in the northern border cities of Mexico and the dynamic demand of the regional market labor. First, it analyzes the evolution of demographic growth and the development of economic activities, in the Mexican borders in urban towns, then it reviews the data from the survey called Encuesta sobre Migracion en la Frontera Norte de Mexico in order to explore the connection between the regional labor market characteristics and the internal and international migration flows." (EXCERPT)

Teledermatology in Tijuana, Mexico.

PubMed

Brown, Megan

2016-12-01

The Health Frontiers in Tijuana (HFiT) clinic is a binational partnership between the University of California, San Diego School of Medicine (San Diego, California); the Universidad Autónoma de Baja California School of Medicine (Tijuana, Mexico); and Desayunador Salesiano Padre Chava, a community grassroots organization in Tijuana, Mexico. Health Frontiers in Tijuana provides accessible quality health care for the underserved in Tijuana's Zona Norte. This article is a narrative meant to share my clinical experience as a dermatology resident who worked with HFiT to establish teledermatology services at this clinic.

Potential risks of the residue from Samarco's mine dam burst (Bento Rodrigues, Brazil).

PubMed

Segura, Fabiana Roberta; Nunes, Emilene Arusievicz; Paniz, Fernanda Pollo; Paulelli, Ana Carolina Cavalheiro; Rodrigues, Gabriela Braga; Braga, Gilberto Úbida Leite; Dos Reis Pedreira Filho, Walter; Barbosa, Fernando; Cerchiaro, Giselle; Silva, Fábio Ferreira; Batista, Bruno Lemos

2016-11-01

On November 5th, 2015, Samarco's iron mine dam - called Fundão - spilled 50-60 million m 3 of mud into Gualaxo do Norte, a river that belongs to Rio Doce Basin. Approximately 15 km 2 were flooded along the rivers Gualaxo do Norte, Carmo and Doce, reaching the Atlantic Ocean on November 22nd, 2015. Six days after, our group collected mud, soil and water samples in Bento Rodrigues (Minas Gerais, Brazil), which was the first impacted area. Overall, the results, water samples - potable and surface water from river - presented chemical elements concentration according to Brazilian environmental legislations, except silver concentration in surface water that ranged from 1.5 to 1087 μg L -1 . In addition, water mud-containing presented Fe and Mn concentrations approximately 4-fold higher than the maximum limit for water bodies quality assessment, according to Brazilian laws. Mud particle size ranged from 1 to 200 μm. SEM-EDS spot provided us some semi quantitative data. Leaching/extraction tests suggested that Ba, Pb, As, Sr, Fe, Mn and Al have high potential mobilization from mud to water. Low microbial diversity in mud samples compared to background soil samples. Toxicological bioassays (HepG2 and Allium cepa) indicated potential risks of cytotoxicity and DNA damage in mud and soil samples used in both assays. The present study provides preliminary information aiming to collaborate to the development of future works for monitoring and risk assessment. Copyright © 2016 Elsevier Ltd. All rights reserved.

Combinatorial Motor Training Results in Functional Reorganization of Remaining Motor Cortex after Controlled Cortical Impact in Rats

PubMed Central

Combs, Hannah L.; Jones, Theresa A.; Kozlowski, Dorothy A.

2016-01-01

Abstract Cortical reorganization subsequent to post-stroke motor rehabilitative training (RT) has been extensively examined in animal models and humans. However, similar studies focused on the effects of motor training after traumatic brain injury (TBI) are lacking. We previously reported that after a moderate/severe TBI in adult male rats, functional improvements in forelimb use were accomplished only with a combination of skilled forelimb reach training and aerobic exercise, with or without nonimpaired forelimb constraint. Thus, the current study was designed to examine the relationship between functional motor cortical map reorganization after experimental TBI and the behavioral improvements resulting from this combinatorial rehabilitative regime. Adult male rats were trained to proficiency on a skilled reaching task, received a unilateral controlled cortical impact (CCI) over the forelimb area of the caudal motor cortex (CMC). Three days post-CCI, animals began RT (n = 13) or no rehabilitative training (NoRT) control procedures (n = 13). The RT group participated in daily skilled reach training, voluntary aerobic exercise, and nonimpaired forelimb constraint. This RT regimen significantly improved impaired forelimb reaching success and normalized reaching strategies, consistent with previous findings. RT also enlarged the area of motor cortical wrist representation, derived by intracortical microstimulation, compared to NoRT. These findings indicate that sufficient RT can greatly improve motor function and improve the functional integrity of remaining motor cortex after a moderate/severe CCI. When compared with findings from stroke models, these findings also suggest that more intense RT may be needed to improve motor function and remodel the injured cortex after TBI. PMID:26421759

Combinatorial Motor Training Results in Functional Reorganization of Remaining Motor Cortex after Controlled Cortical Impact in Rats.

PubMed

Combs, Hannah L; Jones, Theresa A; Kozlowski, Dorothy A; Adkins, DeAnna L

2016-04-15

Cortical reorganization subsequent to post-stroke motor rehabilitative training (RT) has been extensively examined in animal models and humans. However, similar studies focused on the effects of motor training after traumatic brain injury (TBI) are lacking. We previously reported that after a moderate/severe TBI in adult male rats, functional improvements in forelimb use were accomplished only with a combination of skilled forelimb reach training and aerobic exercise, with or without nonimpaired forelimb constraint. Thus, the current study was designed to examine the relationship between functional motor cortical map reorganization after experimental TBI and the behavioral improvements resulting from this combinatorial rehabilitative regime. Adult male rats were trained to proficiency on a skilled reaching task, received a unilateral controlled cortical impact (CCI) over the forelimb area of the caudal motor cortex (CMC). Three days post-CCI, animals began RT (n = 13) or no rehabilitative training (NoRT) control procedures (n = 13). The RT group participated in daily skilled reach training, voluntary aerobic exercise, and nonimpaired forelimb constraint. This RT regimen significantly improved impaired forelimb reaching success and normalized reaching strategies, consistent with previous findings. RT also enlarged the area of motor cortical wrist representation, derived by intracortical microstimulation, compared to NoRT. These findings indicate that sufficient RT can greatly improve motor function and improve the functional integrity of remaining motor cortex after a moderate/severe CCI. When compared with findings from stroke models, these findings also suggest that more intense RT may be needed to improve motor function and remodel the injured cortex after TBI.

Phlebotomine sandflies (Diptera: Psychodidae) in a sub-Andean forest from the Norte de Santander, Colombia.

PubMed

Hoyos-López, Richard; Bolaños, Rafael; Contreras-Gutierrez, MarIa; Carrero-Sarmiento, Diego

2016-03-01

The recognition of communities of arthropods with medical importance in natural systems constitutes an important step in the prediction of possible epidemic events and/or emergence of infectious diseases in the human population. This is due to anthropogenic impact in natural areas and landscape modification, which changes the dynamics of pathogenic agents, reservoirs, and vector insects. In this study, an inventory was compiled of species of the genus Lutzomyia present in sub-Andean forest from the confluence of the Pamplonita River basin. CDC-light and Shannon traps were used for collecting adult phlebotomine sandflies during the month of October 2013 in a sub-Andean forest from river basin Pamplonita. All specimens were identified using morphological keys. The epidemiological relevance of each species was reported using a literature review about natural infection or vector incrimination with Leishmania species or other pathogens microorganism. A total of 2755 specimens belonging to eight species of the genus Lutzomyia were collected. Out of the eight species, seven belonged to the group verrucarum (Lutzomyia sp--townsendi series, L. ovallesi, L. spinicrassa, L. serrana, L. townsendi, L. nuneztovari and L. pia), while one belonged to the subgenus Helcocyrtomyia (L. hartmanni). A new registry of L. townsendi was observed for the Norte de Santander department. The appreciable diversity of the verrucarum group observed in this area suggest further investigation on the biogeography and evolution of this group, and epidemiological risk for human populations around this area, as there are reports of Leishmania natural infection and favourable conditions for domestication of phlebotomines in rural towns.

School of Medicine of Federal University of Rio Grande Do Norte: A traditional curriculum with innovative trends in medical education.

PubMed

De Oliveira, Daniel Fernandes Mello; Simas, Breno C C; Guimarães Caldeira, Adrian Lucca; Medeiros, Augusto De Galvão E Brito; Freitas, Marise Reis; Diniz, José; Diniz, Rosiane

2018-02-28

The Medical School of the Federal University of Rio Grande do Norte (UFRN) is one of the biggest public medical schools in Northeast Brazil. In the last decade, significant investment in faculty development, innovative learning methodologies and student engagement has been key milestones in educational improvement at this medical school, harnessed to recent political changes that strengthened community-based and emergency education. This study describes how curriculum changes in UFRN Medical School have been responsible for major improvements in medical education locally and which impacts such transformations may have on the educational community. A group of students and teachers revised the new curriculum and established the key changes over the past years that have been responsible for the local enhancement of medical education. This information was compared and contrasted to further educational evidences in order to define patterns that can be reproduced in other institutions. Improvements in faculty development have been fairly observed in the institution, exemplified by the participation of a growing number of faculty members in programs for professional development and also by the creation of a local masters degree in health education. Alongside, strong student engagement in curriculum matters enhanced the teaching-learning process. Due to a deeper involvement of students and teachers in medical education, it has been possible to implement innovative teaching-learning and assessment strategies over the last ten years and place UFRN Medical School at a privileged position in relation to undergraduate training, educational research and professional development of faculty staff.

Presence of Mycobacterium leprae genotype 4 in environmental waters in Northeast Brazil.

PubMed

Holanda, Maísa Viana de; Marques, Livia Erika Carlos; Macedo, Maria Luisa Bezerra de; Pontes, Maria Araci de Andrade; Sabadia, José Antonio Beltrão; Kerr, Ligia Regina Franco Sansigolo; Almeida, Rosa Lívia Freitas; Frota, Cristiane Cunha

2017-01-01

This study quantified Mycobacterium leprae bacilli in environmental water samples from five municipalities in the State of Ceará by quantitative polymerase chain reaction (qPCR) and compared the identified genotypes with those obtained from leprosy patient biopsies. We collected five replicas from each of the 30 selected reservoirs and skin lesion biopsies from 25 new leprosy cases treated at a reference center in Fortaleza, Ceará from 2010 to 2013. The 16S rRNA gene region of M. leprae was amplified by qPCR and a standard curve was created with the pIDTBlue 16SrRNAMlep plasmid. The Juazeiro do Norte water samples and the biopsies were genotyped (single nucleotide polymorphism [SNP] 1 to 4) and the SNP 4 genotypes were subtyped. Of the 149 water samples analyzed, 54.4% were positive for the M. leprae DNA. The M. leprae bacilli copy number ranged from 1.42 × 10 -1 to 1.44 × 10 + 2 . Most biopsies showed SNP type 4 (64%), while all samples from Juazeiro do Norte were SNP type 4, with subtype 4-N appearing at the highest frequency. We suggest that environmental waters containing M. leprae bacilli play an important role in disease transmission, justifying PGL-1 seropositivity in individuals living in areas where there is no reported case, and in leprosy cases individuals who report no previous contact with other case. Therefore, further investigation is needed to clarify disease transmission in this region and to explore the role of the environment. We also suggest that in this area surveillance for leprosy cases should be intensified.

The combination of memantine and galantamine improves cognition in rats: The synergistic role of the α7 nicotinic acetylcholine and NMDA receptors.

PubMed

Nikiforuk, Agnieszka; Potasiewicz, Agnieszka; Kos, Tomasz; Popik, Piotr

2016-10-15

The combination of memantine and acetylcholinesterase inhibitors (AChEIs) is used as a therapeutic strategy to improve cognition in Alzheimer's disease. Among AChEIs, galantamine, which is also a positive allosteric modulator (PAM) of nicotinic acetylcholine receptors (nAChRs), including α7-nAChRs, may be particularly beneficial. The α7-nAChR is involved in interactions between the cholinergic and glutamatergic systems. In the present study, we investigated the potential role of α7-nAChRs in the pro-cognitive effects of this drug combination. To this aim, cognitive performance in rats was assessed using the attentional set shifting task (ASST) and novel object recognition task (NORT). Co-administration of inactive doses of memantine with galantamine facilitated the rats' set-shifting performance and reversed delay-induced deficits in object recognition. These effects were blocked by the α7-nAChR antagonist methyllycaconitine, suggesting that the observed cognitive enhancement is α7-nAChR dependent. Moreover, combined administration of memantine with inactive doses of selective α7-nAChRs PAMs, CCMI and PNU-120596, also improved ASST and NORT performance in a methyllycaconitine-dependent manner. Stimulation of α7-nAChRs may underlie the pro-cognitive effects of combining memantine and galantamine. Our results suggest that memantine, when given with enhancers of α7-nAChRs, may represent an effective strategy for cognitive improvement. Copyright © 2016 Elsevier B.V. All rights reserved.

The Dammam aquifer in Bahrain - Hydrochemical characterization and alternatives for management of groundwater quality

NASA Astrophysics Data System (ADS)

Zubari, Waleed K.

Over-ion of the Dammam aquifer, the principal aquifer in Bahrain, by the agricultural and domestic sectors, has led to its salinization by adjacent brackish and saline water bodies. A hydrochemical study identified the locations of the sources of aquifer salinization and delineated their areas of influence. The investigation indicates that the aquifer water quality is significantly modified as groundwater flows from the northwestern parts of Bahrain, where the aquifer receives its water by lateral underflow from eastern Saudi Arabia, to the southern and southeastern parts. Four types of salinization of the aquifer are identified: brackish-water up-flow from the underlying brackish-water zones in north-central, western, and eastern regions; seawater intrusion in the eastern region; intrusion of sabkha water in the southwestern region; and irrigation return flow in a local area in the western region. Four alternatives for the management of groundwater quality that are available to the water authorities in Bahrain are discussed and their priority areas are proposed, based on the type and extent of each salinization source, in addition to groundwater use in that area. The effectiveness of the proposed management options in controlling the degradation of water quality in the Dammam aquifer should be evaluated using simulation modeling. Résumé La surexploitation de l'aquifère de Damman, principal aquifère de Bahreïn, du fait des besoins agricoles et domestiques, a conduit à sa salinisation à partir d'eaux voisines saumâtres et salées. Une étude hydrochimique a identifié les origines de la salinisation de l'aquifère et a délimité leurs zones d'influence. Les recherches montrent que la qualité de l'eau souterraine est modifiée de façon significative pour les écoulements souterrains dirigés vers les secteurs sud et sud-est et provenant de la région nord-ouest de Bahreïn, là où l'aquifère est alimenté latéralement à partir de l'Arabie Saoudite orientale. Quatre types de salinisation de l'eau souterraine ont été identifiés : une drainance verticale en provenance d'eaux saumâtres sous-jacentes dans les régions nord-centrales, ouest et est, une intrusion marine dans la région est, une intrusion d'eau de sebkha dans la région sud-ouest, et le retour d'irrigation dans un secteur localisé de la région sud-ouest. Quatre démarches alternatives de gestion de la qualité des eaux souterraines, acceptables par les services chargés de l'eau à Bahreïn, sont discutées et des zones d'action prioritaire sont proposées, selon le type et l'étendue de chacune des sources de salinisation et en fonction des usages de les eaux souterraines dans chaque secteur. L'efficacité des options de gestion proposées pour le contrôle de la dégradation de la qualité de l'aquifère de Damman devrait être ensuite évaluée au moyen d'un modèle de simulation. Resumen El acuífero de Damman, el más importante de Bahrein, se explota para usos agrícolas y domésticos. La sobreexplotación del mismo ha provocado su salinización por cuerpos de agua salada y salobre cercanos. Un estudio hidroquímico identificó las fuentes de salinización y ayudó a dibujar sus áreas de influencia. La calidad del agua subterránea se modifica significativamente en la dirección del flujo, desde el noroeste del país, donde las entradas son laterales y procedentes de Arabia Saudí, hacia el sur y el sudeste. Se han identificado cuatro tipos de salinización: flujo ascendente de agua salobre en las regiones norte-central, este y oeste; intrusión de agua marina en la región este; intrusión de agua salobre al sudoeste y, finalmente, retorno de riego en un área local de la región oeste. Se discuten cuatro alternativas para la gestión del agua y se proponen áreas prioritarias basadas en el tipo y la extensión de cada fuente de salinización y en los usos de agua subterránea en cada zona. La efectividad de las opciones de gestión propuestas para controlar la degradación de la calidad del agua en el acuífero Damman deberá evaluarse mediante simulaciones realizadas con un modelo numérico

Phylogenetic and morphologic evidence confirm the presence of a new montane cloud forest associated bird species in Mexico, the Mountain Elaenia (Elaenia frantzii; Aves: Passeriformes: Tyrannidae)

PubMed Central

Ortiz-Ramírez, Marco F.; Ríos-Muñoz, César A.; Cayetano-Rosas, Héctor; Bowie, Rauri C. K.; Navarro-Sigüenza, Adolfo G.

2016-01-01

Here we provide evidence to support an extension of the recognized distributional range of the Mountain Elaenia (Elaenia frantzii) to include southern Mexico. We collected two specimens in breeding condition in northwestern Sierra Norte de Chiapas, Mexico. Morphologic and genetic evidence support their identity as Elaenia frantzii. We compared environmental parameters of records across the entire geographic range of the species to those at the northern Chiapas survey site and found no climatic differences among localities. PMID:26855860

[Labor migration to the United States by natives from the State of Mexico].

PubMed

Gonzalez Becerril, J G

1998-01-01

Based primarily on data from the Encuesta sobre Migracion en la Frontera Norte de Mexico, results of a study of international migration from the Mexican state of Mexico to the United States over time are presented The author notes that from 1942 to 1964, labor migration between the two countries was organized under an agreement between the two governments concerned. However, since that agreement ended, an increasing volume of illegal labor migration has occurred in response to the economic situation. Attention is given to migrant characteristics, the characteristics of illegal immigrants deported back to Mexico, and migrant remittances.

Andes Virus and First Case Report of Bermejo Virus Causing Fatal Pulmonary Syndrome

PubMed Central

Della Valle, Marcelo González; Alai, María Garcia; Cortada, Pedro; Villagra, Mario; Gianella, Alberto

2002-01-01

Two suspected hantavirus pulmonary syndrome (HPS) cases from Bolivia were confirmed by enzyme-linked immunosorbent assay. (ELISA)-ANDES was performed using N-Andes recombinant antigen serology in May and July 2000. Clot RNAs from the two patients were subjected to reverse transcription–polymerase chain reaction (PCR) amplification and sequencing. We describe two characterized cases of HPS. One was caused by infection with Bermejo virus and the other with Andes Nort viral lineage, both previously obtained from Oligoryzomys species. This is the first report of molecular identification of a human hantavirus associated with Bermejo virus. PMID:11971782

Field Trial of Attenuated Salmonella Typhi Live Oral Vaccine TY21A in Liquid and Enteric-Coated Formulations and Epidemiological Survey for Incidence of Diarrhea due to Shigella Species

DTIC Science & Technology

1989-03-01

and absolute efficacy of three doses of Ty2la vaccine given in enteric-coated capsule or liquid formulation. Intensive clinical and bacteriologic...TABLES Table 1. Evaluation of the efficacy of three doses of the enteric-coated capsule formulation of Ty2la live oral vaccine given within one week in...November, 1986 thzough February, 1989 of a field trial in Area Sur Oriente and Area Norte assessing the efficacy of Ty21a vaccine in liquid or enteric

Field Trial of Attentuated Salmonella Typhi Live Oral Vaccine Ty21a in Liquid and Enteric-Coated Formulations and Epidemiological Survey for Incidence of Diarrhea due to Shigella Species

DTIC Science & Technology

1988-05-18

trial was initiated in Area Sur Oriente and Area Norte, Santiago, Chile,. to compare the relative and absolute’ efficacy of three doses of Ty2la vaccine ...neighboirhood of Area Oriente, Santiago with the broad objective of pr3paring a field area uhere the efficacy of vaccines against Shigella...The high incidence rates of Shisella, ETEC, and EPEC infection make Santa Julia a suitable place for testing the efficacy of vaccines against these

Negligent and intentional fires in Portugal: the role of human and biophysical drivers on the temporal distribution

NASA Astrophysics Data System (ADS)

Parente, Joana; Pereira, Mário; Amraoui, Malik; Tedim, Fantina

2017-04-01

Portugal is the European country with higher number of fires (NF) and burnt area (BA) per unit of land area. The annual number of fires for which the cause of fire is known is not constant and relatively small (typically less than 50% of annual number of records). Nevertheless, the analysis of the fire causes reveals that the vast majority (99%) of the fires in Portugal are of human origin and only a small fraction are of natural origin (1% caused by lightning). The study period will be the recent years of 2012 - 2014, when fire recording procedures are more reliable and the cause of ignition was assessed for more than 50% (19376) of the fires. The fires with approximately seventy different causes of fire defined/recognized by the Portuguese Forest Service (ICNF) were grouped into negligent, intentional and natural fires. For this study the authors proposes the use of the Nomenclature of Territorial Units for Statistics level II, which divides Portugal in 5 basic economic regions, namely Norte, Centro, Área Metropolitana de Lisboa, Alentejo, and Algarve. Most of the fires (54%) occur in the so-called critical period defined between July and September, but high wildfire activity may also occur in few periods of the remaining months (especially in February and March). The intentional fires represent 40% of total NF but accounts for 53% of total BA during the study period. The temporal distribution are described and interpreted in terms of the climate, fire weather, land use land cover (LULC), distance to communication routes (roads and railways) and topographic variables (altitude, slope) using statistical analysis and GIS techniques. Results points to: a) higher number of negligent than intentional fires; b) higher BA on critical period in years 2012 and 2013; c) decrease in time and decrease from critical period to non-critical period of the number of fires, in all regions; and d) the dominant role of fire weather in the observed temporal patterns. We strongly believe that the findings of this study contribute to a better fire prevention, firefighting and crisis management. Acknowledgements: This work was supported by: (i) the project Interact - Integrative Research in Environment,Agro-Chain and Technology, NORTE-01-0145-FEDER-000017, research line BEST, cofinanced by FEDER/NORTE 2020; (ii) the FIREXTR project, PTDC/ATP¬GEO/0462/2014; and, (iii) European Investment Funds by FEDER/COMPETE/POCI-Operacional Competitiveness and Internacionalization Programme, under Project POCI-01-0145-FEDER-006958 and National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UID/AGR/04033. We are especially grateful to ICNF for providing the fire data.

The novel complex allele [A238V;F508del] of the CFTR gene: clinical phenotype and possible implications for cystic fibrosis etiological therapies.

PubMed

Diana, Anna; Polizzi, Angela Maria; Santostasi, Teresa; Ratclif, Luigi; Pantaleo, Maria Giuseppina; Leonetti, Giuseppina; Iusco, Danila Rosa; Gallo, Crescenzio; Conese, Massimo; Manca, Antonio

2016-06-01

Few mutations in cis have been annotated for F508del homozygous patients. Southern Italy patients who at a first analysis appeared homozygous for the F508del mutation (n=63) or compound heterozygous for the F508del and another mutation in the cystic fibrosis transmembrane conductance regulator gene (n=155) were searched for the A238V mutation in exon 6. The allelic frequency of the complex allele [A238V;F508del] was 0.04. When the whole data set was used (comprised also of 56 F508del/F508del and 34 F508del/other mutation controls), no differences reached the statistical significance in the clinical parameters, except chloride concentrations which were lower in [A238V;F508del]/other mutation compared with F508del/other mutation (P=0.03). The two study groups presented less complications than the control groups. Within the minimal data set (34 F508del/F508del, 27 F508del/other mutation, 4 [A238V;F508del]/F508del cases and 5 [A238V;F508del]/other mutation cases); that is, presenting all the variables in each patient, forced expiratory volume in 1 s and forced vital capacity presented a trend to lower levels in the study groups in comparison with the F508del/F508del group, and C-reactive protein approximated statistically significant higher levels in the [A238V;F508del]/other mutation as compared with F508del/F508del patients (P=0.09). The analysis of statistical dependence among the variables showed a significant anticorrelation between chloride and body mass index in the [A238V;F508del]/other mutation group. In conclusion, the complex allele [A238V;F508del] seems to be associated with less general complications than in the control groups, on the other hand possibly giving a worse pulmonary phenotype and higher systemic/local inflammatory response. These findings have implications for the correct recruitment and clinical response of F508del patients in the clinical trials testing the new etiological drugs for cystic fibrosis.

Blonanserin ameliorates phencyclidine-induced visual-recognition memory deficits: the complex mechanism of blonanserin action involving D₃-5-HT₂A and D₁-NMDA receptors in the mPFC.

PubMed

Hida, Hirotake; Mouri, Akihiro; Mori, Kentaro; Matsumoto, Yurie; Seki, Takeshi; Taniguchi, Masayuki; Yamada, Kiyofumi; Iwamoto, Kunihiro; Ozaki, Norio; Nabeshima, Toshitaka; Noda, Yukihiro

2015-02-01

Blonanserin differs from currently used serotonin 5-HT₂A/dopamine-D₂ receptor antagonists in that it exhibits higher affinity for dopamine-D₂/₃ receptors than for serotonin 5-HT₂A receptors. We investigated the involvement of dopamine-D₃ receptors in the effects of blonanserin on cognitive impairment in an animal model of schizophrenia. We also sought to elucidate the molecular mechanism underlying this involvement. Blonanserin, as well as olanzapine, significantly ameliorated phencyclidine (PCP)-induced impairment of visual-recognition memory, as demonstrated by the novel-object recognition test (NORT) and increased extracellular dopamine levels in the medial prefrontal cortex (mPFC). With blonanserin, both of these effects were antagonized by DOI (a serotonin 5-HT₂A receptor agonist) and 7-OH-DPAT (a dopamine-D₃ receptor agonist), whereas the effects of olanzapine were antagonized by DOI but not by 7-OH-DPAT. The ameliorating effect was also antagonized by SCH23390 (a dopamine-D₁ receptor antagonist) and H-89 (a protein kinase A (PKA) inhibitor). Blonanserin significantly remediated the decrease in phosphorylation levels of PKA at Thr(197) and of NR1 (an essential subunit of N-methyl-D-aspartate (NMDA) receptors) at Ser(897) by PKA in the mPFC after a NORT training session in the PCP-administered mice. There were no differences in the levels of NR1 phosphorylated at Ser(896) by PKC in any group. These results suggest that the ameliorating effect of blonanserin on PCP-induced cognitive impairment is associated with indirect functional stimulation of the dopamine-D₁-PKA-NMDA receptor pathway following augmentation of dopaminergic neurotransmission due to inhibition of both dopamine-D₃ and serotonin 5-HT₂A receptors in the mPFC.

iss01e5107

NASA Image and Video Library

2000-12-01

ISS01-E-5107 (December 2000) --- This nadir view of a Chilean glaciated area was provided by one of the early December digital still camera images down linked from the International Space Station (ISS) to ground controllers in Houston. The remote headwaters of the Rio de la Colonia are located on the eastern flank of the Cerro Pared Norte, a high, coastal range of the Andes in southern Chile. This is but a portion of a larger glaciated region of the Chilean coast located at only 47 degrees south latitude. The river actually begins its flow just off the top of this scene at the foot of the two large, converging, valley glaciers near the center. Some of the numerous lakes visible are tinted by the fine glacial sediments suspended in their waters. Note the shards of ice that have calved from the glaciers into the lakes on the left. Also note the shadows of the crest of the over 14,000-foot mountains (lower center). The remote headwaters of the Rio de la Colonia are located on the eastern flank of the Cerro Pared Norte, a high, coastal range of the Andes in southern Chile. This is a but a portion of a larger glaciated region of the Chilean coast located at only 47 degrees south latitude. The river actually begins its flow just off the top of this scene at the foot of the two large, converging, valley glaciers near the center. Some of the numerous lakes visible are tinted by the fine glacial sediments suspended in their waters. Note the shards of ice that have calved from the glaciers into the lakes on the left. Also note the shadows of the crest of the over 14,000-foot mountains (lower center).

Is polychaete family-level sufficient to assess impact on tropical estuarine gradients?

NASA Astrophysics Data System (ADS)

Nóbrega-Silva, Climélia; Patrício, Joana; Marques, João Carlos; Olímpio, Monalisa dos Santos; Farias, Jéssica Natyelle Barros; Molozzi, Joseline

2016-11-01

Regular, robust monitoring programs set up to assess the environmental conditions of aquatic systems often target different biological groups. And, of these, macroinvertebrate communities and particularly the class Polychaeta are frequently used. Identifying these organisms takes time, money and specialized expertise to ensure correct identification to the lowest possible taxonomic level. Identification errors can lead to an erroneous assessment. The concept of taxonomic sufficiency has been proposed both to minimize errors and to save time and money. This study tested the usefulness of this concept in tropical estuaries in northeast Brazil. We selected two transitional systems with different degrees of human impact due to different land uses and different conservation systems: the Mamanguape estuary, which is in an environmental conservation unit for sustainable use, and the highly impacted, urban Paraíba do Norte estuary. The results clearly showed that nutrient concentrations were markedly higher in the Paraíba do Norte estuary in the dry season and that the composition of the polychaete assemblages differed between the two estuaries as well as along the spatial gradient of each estuary. The use of either genus or family level led to equivalent representation in each system in terms of taxon richness and both the Margalef and Shannon-Wiener diversity indices. Both taxonomic levels described similar changes in the polychaete assemblage along the estuarine gradients. Based on our findings, the use of a coarser taxonomic level (i.e., family) is a good option when the aim is to implement a monitoring program in tropical estuaries with the polychaete assemblages as one of the target groups. This time-efficient taxonomic resolution can help improve sampling designs and allow long-term monitoring studies without losing much vital information.

Exercise preconditioning improves behavioral functions following transient cerebral ischemia induced by 4-vessel occlusion (4-VO) in rats.

PubMed

Tahamtan, Mahshid; Allahtavakoli, Mohammad; Abbasnejad, Mehdi; Roohbakhsh, Ali; Taghipour, Zahra; Taghavi, Mohsen; Khodadadi, Hassan; Shamsizadeh, Ali

2013-12-01

There is evidence that exercise decreases ischemia/reperfusion injury in rats. Since behavioral deficits are the main outcome in patients after stroke, our study was designed to investigate whether exercise preconditioning improves the acute behavioral functions and also brain inflammatory injury following cerebral ischemia. Male rats weighing 250-300 g were randomly allocated into five experimental groups. Exercise was performed on a treadmill 30min/day for 3 weeks. Ischemia was induced by 4-vessel occlusion method. Recognition memory was assessed by novel object recognition task (NORT) and step-through passive avoidance task. Sensorimotor function and motor movements were evaluated by adhesive removal test and ledged beam-walking test, respectively. Brain inflammatory injury was evaluated by histological assessment. In NORT, the discrimination ratio was decreased after ischemia (P < 0.05) and exercise preconditioning improved it in ischemic animals. In the passive avoidance test, a significant reduction in response latency was observed in the ischemic group. Exercise preconditioning significantly decreased the response latency in the ischemic rats (P < 0.001). In the adhesive removal test, latency to touch and remove the sticky labels from forepaw was increased following induction of ischemia (all P < 0.001) and exercise preconditioning decreased these indices compared to the ischemic group (all P < 0.001). In the ledged beam-walking test, the slip ratio was increased following ischemia (P < 0.05).  In the ischemia group, marked neuronal injury in hippocampus was observed. These neuropathological changes were attenuated by exercise preconditioning (P < 0.001). Our results showed that exercise preconditioning improves behavioral functions and maintains more viable cells in the dorsal hippocampus of the ischemic brain.

[Construction of knowledge in odontology: the scientific production in debate].

PubMed

Amorim, Karla Patrícia Cardoso; Alves, Maria do Socorro Costa Feitosa; Germano, Raimunda Medeiros

2005-01-01

Analyze, quantitatively, which odontology magazines are being consulted and read by surgeon-dentists, and evaluate the profiles of the mostly cited. 370 polls were made, during the XVII Congresso Pernambucano de Odontologia (Pernambucan Congress of Odontology) and the IX Congresso de Odontologia do Rio Grande do Norte (Congress of Odontology of Rio Grande do Norte), which took place, respectively, in April and September 2004. The participants were volunteering professionals divided among General Practice (37.84%) and ten differing specialties (62.16%); of which 77.02% had up to ten years of graduation. Resulting the researches made, 620 quotes were generated, in which, 35 different magazines, national and international, were quoted. By analyzing the data collected, we observe that three magazines summed more than half of the quota (52.74%), which are: Revista da Associação Paulista de Cirurgiões Dentistas-APCP (Magazine of the Paulista Association of Surgeon-Dentists), Revista da Associação Brasileira de Odontologia - ABO national (Magazine of the Brazilian Association of Odontology) and the Revista Brasileira de Odontologia-RBO (Brazilian Magazine of Odontology). Despite the participants of the research being, in their majority, specialists, we observe a tendency of a greater consultation of the magazines of general characteristic. These magazines predominantly tackle clinical and technical subjects and present an expressive circulation, great penetration in the odontologic world, easy accessibility and a long time in the market (two of them are over 50 years-old). According to CAPES - QUALIS, all possess a B national concept. Therefore, it is necessary a deepening of this study, so as to analyze qualitatively what kind of subjects and themes these magazines touch, since they influence the odontologic formation and practice.

Contextualizing Obesity and Diabetes Policy: Exploring a Nested Statistical and Constructivist Approach at the Cross-National and Subnational Government Level in the United States and Brazil

PubMed Central

Gómez, Eduardo J.

2017-01-01

Background: This article conducts a comparative national and subnational government analysis of the political, economic, and ideational constructivist contextual factors facilitating the adoption of obesity and diabetes policy. Methods: We adopt a nested analytical approach to policy analysis, which combines cross-national statistical analysis with subnational case study comparisons to examine theoretical prepositions and discover alternative contextual factors; this was combined with an ideational constructivist approach to policy-making. Results: Contrary to the existing literature, we found that with the exception of cross-national statistical differences in access to healthcare infrastructural resources, the growing burden of obesity and diabetes, rising healthcare costs and increased citizens’ knowledge had no predictive affect on the adoption of obesity and diabetes policy. We then turned to a subnational comparative analysis of the states of Mississippi in the United States and Rio Grande do Norte in Brazil to further assess the importance of infrastructural resources, at two units of analysis: the state governments versus rural municipal governments. Qualitative evidence suggests that differences in subnational healthcare infrastructural resources were insufficient for explaining policy reform processes, highlighting instead other potentially important factors, such as state-civil societal relationships and policy diffusion in Mississippi, federal policy intervention in Rio Grande do Norte, and politicians’ social construction of obesity and the resulting differences in policy roles assigned to the central government. Conclusion: We conclude by underscoring the complexity of subnational policy responses to obesity and diabetes, the importance of combining resource and constructivist analysis for better understanding the context of policy reform, while underscoring the potential lessons that the United States can learn from Brazil. PMID:29179290

Estradiol and luteinizing hormone regulate recognition memory following subchronic phencyclidine: Evidence for hippocampal GABA action.

PubMed

Riordan, Alexander J; Schaler, Ari W; Fried, Jenny; Paine, Tracie A; Thornton, Janice E

2018-05-01

The cognitive symptoms of schizophrenia are poorly understood and difficult to treat. Estrogens may mitigate these symptoms via unknown mechanisms. To examine these mechanisms, we tested whether increasing estradiol (E) or decreasing luteinizing hormone (LH) could mitigate short-term episodic memory loss in a phencyclidine (PCP) model of schizophrenia. We then assessed whether changes in cortical or hippocampal GABA may underlie these effects. Female rats were ovariectomized and injected subchronically with PCP. To modulate E and LH, animals received estradiol capsules or Antide injections. Short-term episodic memory was assessed using the novel object recognition task (NORT). Brain expression of GAD67 was analyzed via western blot, and parvalbumin-containing cells were counted using immunohistochemistry. Some rats received hippocampal infusions of a GABA A agonist, GABA A antagonist, or GAD inhibitor before behavioral testing. We found that PCP reduced hippocampal GAD67 and abolished recognition memory. Antide restored hippocampal GAD67 and rescued recognition memory in PCP-treated animals. Estradiol prevented PCP's amnesic effect in NORT but failed to restore hippocampal GAD67. PCP did not cause significant differences in number of parvalbumin-expressing cells or cortical expression of GAD67. Hippocampal infusions of a GABA A agonist restored recognition memory in PCP-treated rats. Blocking hippocampal GAD or GABA A receptors in ovx animals reproduced recognition memory loss similar to PCP and inhibited estradiol's protection of recognition memory in PCP-treated animals. In summary, decreasing LH or increasing E can lessen short-term episodic memory loss, as measured by novel object recognition, in a PCP model of schizophrenia. Alterations in hippocampal GABA may contribute to both PCP's effects on recognition memory and the hormones' ability to prevent or reverse them. Copyright © 2018 Elsevier Ltd. All rights reserved.

Recognition deficits in mice carrying mutations of genes encoding BLOC-1 subunits pallidin or dysbindin.

PubMed

Spiegel, S; Chiu, A; James, A S; Jentsch, J D; Karlsgodt, K H

2015-11-01

Numerous studies have implicated DTNBP1, the gene encoding dystrobrevin-binding protein or dysbindin, as a candidate risk gene for schizophrenia, though this relationship remains somewhat controversial. Variation in dysbindin, and its location on chromosome 6p, has been associated with cognitive processes, including those relying on a complex system of glutamatergic and dopaminergic interactions. Dysbindin is one of the seven protein subunits that comprise the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Dysbindin protein levels are lower in mice with null mutations in pallidin, another gene in the BLOC-1, and pallidin levels are lower in mice with null mutations in the dysbindin gene, suggesting that multiple subunit proteins must be present to form a functional oligomeric complex. Furthermore, pallidin and dysbindin have similar distribution patterns in a mouse and human brain. Here, we investigated whether the apparent correspondence of pallid and dysbindin at the level of gene expression is also found at the level of behavior. Hypothesizing a mutation leading to underexpression of either of these proteins should show similar phenotypic effects, we studied recognition memory in both strains using the novel object recognition task (NORT) and social novelty recognition task (SNRT). We found that mice with a null mutation in either gene are impaired on SNRT and NORT when compared with wild-type controls. These results support the conclusion that deficits consistent with recognition memory impairment, a cognitive function that is impaired in schizophrenia, result from either pallidin or dysbindin mutations, possibly through degradation of BLOC-1 expression and/or function. © 2015 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

Landscape connectivity among remnant populations of guanaco (Lama guanicoe Müller, 1776) in an arid region of Chile impacted by global change.

PubMed

Espinosa, Mara I; Gouin, Nicolas; Squeo, Francisco A; López, David; Bertin, Angéline

2018-01-01

Connectivity between populations plays a key role in the long-term persistence of species in fragmented habitats. This is of particular concern for biodiversity preservation in drylands, since water limited landscapes are typically characterized by little suitable habitat cover, high habitat fragmentation, harsh matrices, and are being rapidly degraded at a global scale. In this study, we modelled landscape connectivity between 11 guanaco Lama guanicoe populations in Chile's arid Norte Chico, a region that supports the last remnant coastal populations of this emblematic herbivore indigenous to South America. We produced a habitat suitability model to derive a regional surface resistance map, and used circuit theory to map functional connectivity, investigate the relative isolation between populations, and identify those that contribute most to the patch connectivity network. Predicted suitable habitat for L. guanicoe represented about 25% of the study region (i.e., 29,173 km 2 ) and was heterogeneously distributed along a continuous stretch along the Andes, and discontinuous patches along the coast. As a result, we found that high connectivity current flows in the mid and high Andes formed a wide, continuous connectivity corridor, enabling connectivity between all high Andean populations. Coastal populations, in contrast, were more isolated. These groups demonstrate no inter-population connectivity between themselves, only with higher altitude populations, and for two of them, animal movement was linked to the effectiveness of wildlife crossings along the Pan-American highway. Our results indicate that functional connectivity is an issue of concern for L. guanicoe in Chile's Norte Chico, implying that future conservation and management plans should emphasize strategies aimed at conserving functional connectivity between coastal and Andean populations, as well as the protection of habitat patches likely to act as stepping stones within the connectivity network.

The importance of XRD analysis in provenance and palaeoenvironmental studies of the Piedras de Afilar Formation, Neoproterozoic of Uruguay

NASA Astrophysics Data System (ADS)

Pamoukaghlian, K.; Poiré, D. G.; Gaucher, C.; Uriz, N.; Cingolani, C.; Frigeiro, P.

2009-04-01

The Piedras de Afilar Formation crops out in the southeast part of Uruguay, forming part of the Tandilia Terrane (sensu Bossi et al. 2005). Pamoukaghlian et al. (2006) and Gaucher et al. (2008) have published δ13C, δ18O and U/Pb SHRIMP results, which indicate a Neoproterozoic age for this formation. The palaeoenvironment has been defined as a shallow marine platform based on the presence of interference ripples, hummocky and mega-hummocky cross-stratification. X-ray diffraction (XRD) analyses help to better constrain the palaeoenvironment: the presence of chlorite/smectite found in black shales, suggest a reducing environment, and abundant illite indicates a cold to temperate climate. Provenance studies have been undertaken that utilise a combination of detailed palaeocurrent measurements, petrographic descriptions, XRD analyses, and geochemical isotopic analyses, including U/Pb SHRIMP determinations. Mineral compositional diagrams for sandstones suggest a stable cratonic provenance. Palaeocurrents are mainly from the NNE, indicating a provenance from the cratonic areas of the Tandilia Terrane. The illite crystal index indicates diagenetic to low-metamorphic conditions for the sequence; this is important to confirm that the identified minerals are authigenic. Clay minerals identified by XRD analysis of sandstones from the siliciclastic member are illite (80 - 90%), kaolinite (5 - 10%), and chlorite (5 - 10%). This is consistent with a provenance from the cratonic areas (quartz-feldspar dominated rock types). Isotopic analyses have been undertaken to provide better constraints on the tectonic setting. U/Pb SHRIMP ages for the youngest zircons are 990 Ma (Gaucher et al. 2008), and the basal granite (Granito de la Paz) is 2056 ± 11 Ma (Hartmann et al. 2001), suggesting a provenance from the Archaean basement for the Piedras de Afilar Formation, like its counterparts in the Rio de la Plata Craton. References Bossi, J., Piñeyro, D., Cingolani, C. (2005). El límite norte del Terreno Piedra Alta (Uruguay). Importancia de la faja milonítica sinestral de Colonia. Actas XVI Congreso Argentino de Geología, de La Plata. Gaucher, C., Poiré, D.G., Finney, S.C., Valencia, V.a., Blanco, G., Pamoukaghlian, K., Gómez Peral, L. (2008). Detrital zircón ages of Neoproterozoic sedimentary successions in Uruguay and Argentina: Insights into the geological evolution of the Rio de la Plata Craton. Precambrian Research. Hartmann, L.A., Campal, N., Santos, J.O., Mc. Neughton, N.J., Schipilov, A., Lafon, J.M. (2001). Archean crust in the Rio de la Plata Craton, Uruguay - SHRIMP U-Pb zircon reconnaissance geochronology. Journal of South American Earth Science, 14, 557-570. Pamoukaghlian, K., Gaucher, C., Bossi, J., Sial, N., Poire, D.G. (2006). First C and O isotopic data for the Piedras de Afilar Formation, Tandilia Terrane, Uruguay: their bearing on correlation and age. Fifth South American Symposium on Isotope Geology, Punta del Este.

77 FR 31032 - National Institute on Aging; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

... applications. Place: Marina del Rey Hotel, 13534 Bali Way, Marina del Rey, CA 90292. Contact Person: Bita... applications. Place: Marina del Rey Hotel, 13534 Bali Way, Marina del Rey, CA 90292. Contact Person: Ramesh... and evaluate grant applications. Place: Marina del Rey Hotel, 13534 Bali Way, Marina del Rey, CA 90292...

33 CFR 80.1118 - Marina Del Rey, CA.

Code of Federal Regulations, 2010 CFR

2010-07-01

... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del Rey... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Marina Del Rey, CA. 80.1118...

33 CFR 80.1118 - Marina Del Rey, CA.

Code of Federal Regulations, 2012 CFR

2012-07-01

... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del Rey... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Marina Del Rey, CA. 80.1118...

33 CFR 80.1118 - Marina Del Rey, CA.

Code of Federal Regulations, 2013 CFR

2013-07-01

... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del Rey... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marina Del Rey, CA. 80.1118...

33 CFR 80.1118 - Marina Del Rey, CA.

Code of Federal Regulations, 2011 CFR

2011-07-01

... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del Rey... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Marina Del Rey, CA. 80.1118...

33 CFR 80.1118 - Marina Del Rey, CA.

Code of Federal Regulations, 2014 CFR

2014-07-01

... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del Rey... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Marina Del Rey, CA. 80.1118...

Courtship behavior of different wild strains of Ceratitis Capitata (Diptera: Tephritidae)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Briceno, D.; Eberhard, W.; Vilardi, J.

This study documents differences in the courtship behavior of wild strains of Ceratitis capitata (Wiedemann) from Madeira (Portugal), Hawaii (U.S.A.), Costa Rica, and Patagonia (Argentina). Some traits showed large variations and others substantial overlaps. The angle at which the male faced toward the female at the moment of transition from continuous wing vibration and intermittent buzzing changed very little during the course of courtship in all strains, but males from Madeira tended to face more directly toward the female than other males. Females tended to look more, and more directly, toward the males as courtship progressed in all strains. Themore » distance between male and female tended to decrease as courtship proceeded in all strains, but the distances at which males initiated continuous vibration, intermittent buzzing, and jumped onto the female were relatively less variable between strains, except for the strain from Costa Rica. Flies of Madeira courted for longer and the male moved his head and buzzed his wings longer than the other strains. (author) [Spanish] Este estudio documenta diferencias en el comportamiento de cortejo de cepas silvestres de Ceratitis capitata (Wied.) provenientes de Madeira (Portugal), Hawaii (Estados Unidos de Norte America), Costa Rica y Patagonia (Argentina). Algunas caracteristicas mostraron grandes variaciones y traslape substancial. Los angulos a los cuales los machos miraron hacia las hembras cambiaron muy poco en el momento de la transicion de la vibracion continua al zumbido intermitente durante el curso del cortejo en todo las cepas, pero los machos de Madeira tendieron a enfrentar mas directamente a la hembra que otros machos. Los angulos de las hembras disminuyeron claramente durante el cortejo en todas las cepas. La distancia entre el macho y la hembra tendio a disminuir conforme el cortejo continuaba en todas las cepas, pero las distancias a las cuales los machos iniciaron la vibracion continua, el zumbido intermitente, y el salto sobre la hembra eran relativamente menos variables entre cepas excepto la cepa de Costa Rica. Moscas de Madeira cortejaron mas tiempo y el macho moviosu cabeza y zumbaba sus alas mas prolongadamente que las otras cepas. (author)« less

Enhancement of knowledge construction activities utilizing 21st century learning design rubric

NASA Astrophysics Data System (ADS)

Pedoche, Margarette Anne U.; Taladua, Janica Mae M.; Panal, Geicky Pearl C.; Magsayo, Joy R.; Guarin, Rica Mae B.; Myrna, H. Lahoylahoy

2018-01-01

The main objective of the study was to enhance knowledge construction activities on its design particularly the objectives, support materials, student activities and assessment tools. Activities from the 2nd Quarter of Science Learners Material were the basis in the adaptation of activities. The adapted activities were evaluated by the In-service Science teachers and undergone modification by the researchers based on the teacher's comments and suggestions. It was then evaluated, revised, and validated, tried-out using the 21st CLD Rubric. Subjects of the study were 110 students from Grade 7-B, Grade 7-D, Grade 7-F in Geronima Cabrera National High School, Kolambugan, Lanao del Norte during the academic year 2016-2017, the study to determine their learning capabilities investigated by the use of Knowledge Construction Activities in the 21st Century Classroom, to investigate how the lessons were understood and appreciated by students, to stimulate interpretation, analysis, synthesizing, or evaluating ideas and develop critical thinking. Both quantitative and qualitative data were obtained from the students' scores in three activities. Results showed that there was a significant difference between the pretest and posttest scores of students. Mean scores between the pretest and posttest showed a mean difference of 3.35, thus the null hypothesis was rejected. It could be concluded with sufficient evidence to show that the students had basically low prior knowledge about the topic ecosystem. A significant difference was seen in the pretest and posttest, scores of the activities and Ecosystem model results after the implementation phase that a knowledge construction type of activity was better than the traditional one for it promoted meaningful learning and active engagement of students. Based on the results, it was clear that the use of knowledge construction activities had an effect on student's achievement in comparison to traditional teaching method. Thus, it was recommended for teachers to design more activities to enhance and develop students' knowledge construction and for teachers to start using knowledge construction in the classroom to further improve students' performance.

TEMPORAL-SPATIAL ANALYSIS OF U.S.- MEXICO BORDER ENVIRONMENTAL FINE AND COARSE PM AIR SAMPLE EXTRACT ACTIVITY IN HUMAN BRONCHIAL EPITHELIAL CELLS

PubMed Central

Lauer, Fredine T.; Mitchell, Leah A.; Bedrick, Edward; McDonald, Jacob D.; Lee, Wen-Yee; Li, Wen-Whai; Olvera, Hector; Amaya, Maria A.; Berwick, Marianne; Gonzales, Melissa; Currey, Robert; Pingitore, Nicholas E.; Burchiel, Scott W.

2009-01-01

Particulate matter less than 10 μm (PM10) has been shown to be associated with aggravation of asthma and respiratory and cardiopulmonary morbidity. There is also great interest in the potential health effects of PM 2.5. Particulate matter (PM) varies in composition both spatially and temporally depending on the source, location and seasonal condition. El Paso County which lies in the Paso del Norte airshed is a unique location to study ambient air pollution due to three major points: the geological land formation, the relatively large population and the various sources of PM. In this study, dichotomous filters were collected from various sites in El Paso County every seven days for a period of one year. The sampling sites were both distant and near border crossings, which are near heavily populated areas with high traffic volume. Fine (PM2.5) and Coarse (PM10-2.5) PM filter samples were extracted using dichloromethane and were assessed for biologic activity and polycyclic aromatic (PAH) content. Three sets of marker genes human BEAS2B bronchial epithelial cells were utilized to assess the effects of airborne PAHs on biologic activities associated with specific biological pathways associated with airway diseases. These pathways included in inflammatory cytokine production (IL-6, IL-8), oxidative stress (HMOX-1, NQO-1, ALDH3A1, AKR1C1), and aryl hydrocarbon receptor (AhR)-dependent signaling (CYP1A1). Results demonstrated interesting temporal and spatial patterns of gene induction for all pathways, particularly those associated with oxidative stress, and significant differences in the PAHs detected in the PM10-2.5 and PM 2.5 fractions. Temporally, the greatest effects on gene induction were observed in winter months, which appeared to correlate with inversions that are common in the air basin. Spatially, the greatest gene expression increases were seen in extracts collected from the central most areas of El Paso which are also closest to highways and border crossings. PMID:19410595

8th Argentinean Bioengineering Society Conference (SABI 2011) and 7th Clinical Engineering Meeting

NASA Astrophysics Data System (ADS)

Meschino, Gustavo Javier; Ballarin, Virginia L.

2011-12-01

In September 2011, the Eighteenth Edition of the Argentinean Bioengineering Society Conference (SABI 2011) and Seventh Clinical Engineering Meeting were held in Mar del Plata, Argetina. The Mar del Plata SABI Regional and the School of Engineering of the Universidad Nacional de Mar del Plata invited All bioengineers, engineers, physicists, mathematicians, biologists, physicians and health professionals working in the field of Bioengineering to participate in this event. The overall objectives of the Conference were: To provide discussion of scientific research results in Bioengineering and Clinical Engineering. To promote technological development experiences. To strengthen the institutional and scientific communication links in the area of Bioengineering, mainly between Universities of Latin America. To encourage students, teachers, researchers and professionals to establish exchanges of experiences and knowledge. To provide biomedical engineering technology solutions to the society and contributing ideas for low cost care. Conference photograph Conference photograph Conference photograph Conference photograph EXECUTIVE COMMITTEE SABI 2011 Chair Dra Virginia L Ballarin Universidad Nacional de Mar del Plata Co-Chair Dra Teresita R Cuadrado Universidad Nacional de Mar del Plata - CONICET Local Comittee Dr Gustavo Abraham Universidad Nacional de Mar del Plata - CONICET Dra Josefina Ballarre Universidad Nacional de Mar del Plata - CONICET Dr Eduardo Blotta Universidad Nacional de Mar del Plata Dra Agustina Bouchet Universidad Nacional de Mar del Plata Dr Marcel Brun Universidad Nacional de Mar del Plata Dra Silvia Ceré Universidad Nacional de Mar del Plata - CONICET Dra Mariela Azul Gonzalez Universidad Nacional de Mar del Plata - CONICET Dra Lucia Isabel Passoni Universidad Nacional de Mar del Plata Dr Juan Ignacio Pastore Universidad Nacional de Mar del Plata - CONICET Dra Adriana Scandurra Universidad Nacional de Mar del Plata SCIENTIFIC ADVISORY COMMITTEE President Dr Gustavo Meschino Universidad Nacional de Mar del Plata Comittee Dr Gustavo Abraham Universidad Nacional de Mar del Plata - CONICET Mg Rubén Acevedo Universidad Nacional de Entre Ríos Ing Pablo Agüero Universidad Nacional de Mar del Plata Ing Mariela Ambrustolo Universidad Nacional de Mar del Plata Dr Ricardo Armentano Universidad Favaloro Dra Virginia L Ballarin Universidad Nacional de Mar del Plata Dra Josefina Ballarre Universidad Nacional de Mar del Plata - CONICET Dr Eduardo Blotta Universidad Nacional de Mar del Plata Ing Marco Benalcázar Universidad Nacional de Mar del Plata Mg Freddy Geovanny Benalcázar Palacios Escuela Superior Politécnica de Chimborazo, Ecuador Dr Roberto Boeri Universidad Nacional de Mar del Plata - CONICET - INTEMA Dra Agustina Bouchet Universidad Nacional de Mar del Plata Dr Ariel Braidot Universidad Nacional de Entre Ríos Dr Marcel Brun Universidad Nacional de Mar del Plata Dra Silvia Ceré Universidad Nacional de Mar del Plata - CONICET Ing Fernando Clara Universidad Nacional de Mar del Plata Dr Raúl Correa Prado Universidad Nacional de San Juan Bioing Pablo Cortez Universidad Nacional de Mar del Plata Dra Teresita R Cuadrado Universidad Nacional de Mar del Plata - CONICET Ing Eduardo De Forteza Universidad Favaloro Dra Mariana Del Fresno Universidad Nacional del Centro de la Provincia de Buenos Aires Dr Martín Diaz Informática Médica Hospital Aleman de Buenos Aires - GIBBA Ing Julio César Doumecq Universidad Nacional de Mar del Plata Mg Ana María Echenique Universidad Nacional de San Juan Bioing Pedro Escobar Universidad Nacional del Centro, Olavarría, Pcia de Buenos Aires Dr Fernando Daniel Farfán Universidad Nacional de Tucumán Dr Carmelo Felice Universidad Nacional de Tucumán - CONICET Dr Elmer Fernández Universidad Católica de Córdoba - CONICET Ing José Flores Universidad Nacional de Entre Ríos Dr Arturo Gayoso Universidad Nacional de Mar del Plata Dra Bioing Agustina Garcés Universidad Nacional de San Juan ¬- CONICET Bioing Luciano Gentile Universidad Favaloro Mg María Eugenia Gómez Universidad Nacional de San Juan Dr Claudio González Universidad Nacional de Mar del Plata Mg Esteban González Universidad Nacional de Mar del Plata Dra Mariela A Gonzalez Universidad Nacional de Mar del Plata - CONICET Dr Juan Pablo Graffigna Universidad Nacional de San Juan Dra Myriam Herrera Universidad Nacional de Tucumán - CONICET Dr Roberto Hidalgo Universidad Nacional de Mar del Plata Dr Roberto Isoardi Fundación Escuela de Medicina Nuclear de Mendoza - CNEA Dra Susana Jerez Universidad Nacional de Tucumán Dr Eric Laciar Universidad Nacional de San Juan - CONICET Bioing Roberto Leonarduzzi Universidad Nacional de Entre Ríos Mg Norberto Lerendegui Instituto Tecnológico de Buenos Aires Dra Natalia López Universidad Nacional de San Juan - CONICET Dra Rossana Madrid Universidad Nacional de Tucuman - CONICET Ing Florencia Montini Ballarin Universidad Nacional de Mar del Plata - CONICET Dra Emilce Moler Universidad Nacional de Mar del Plata Dr Jorge Castiñieira Moreira Universidad Nacional de Mar del Plata Dr Silvia Murialdo Universidad Nacional de Mar del Plata - CIC Dr Juan Manuel Olivera Universidad Nacional de Tucumán Dra Lucia Isabel Passoni Universidad Nacional de Mar del Plata Dr Juan Ignacio Pastore Universidad Nacional de Mar del Plata - CONICET Dra María Elisa Pérez Universidad Nacional de San Juan Mg Franco M Pessana Universidad Favaloro Dr Julio Politti Universidad Nacional de Tucumán Dr Marcelo Risk Universidad Nacional de Buenos Aires - CONICET Ing Raúl Rivera Universidad Nacional de Mar del Plata Mg Luis Rocha Universidad Nacional de Tucumán - SIPROSA Dra Silvia Rodrigo Universidad Nacional de San Juan Dra Viviana Rotger Universidad Nacional de Tucumán Dr Leonardo Rufiner Universidad Nacional de Entre Rios - CONICET Dra Estela Ruiz Universidad Nacional de Tucumán Dr Martín Santiago Universidad Nacional del Centro de la Provincia de Buenos Aires Dra Adriana Scandurra Universidad Nacional de Mar del Plata Ing Graciela Secreto Universidad Favaloro Mg Pablo Solarz Universidad Nacional de Tucumán Mg Carolina Tabernig Universidad Nacional de Entre Ríos Ing Ricardo Taborda Universidad Nacional de Córdoba Dra María Eugenia Torres Universidad Nacional de Entre Ríos - CONICET Ing Juan Carlos Tulli Universidad Nacional de Mar del Plata Dr Gerardo Tusman Hospital Privado de Comunidad, Mar del Plata Dr Santiago Urquiza Universidad Nacional de Mar del Plata Mg Andrés Valdez Universidad Nacional de San Juan Dr Máximo Valentinuzzi INSIBIO - CONICET - Universidad Nacional de Tucumán

The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility*

PubMed Central

Mitzelfelt, Katie A.; Limphong, Pattraranee; Choi, Melinda J.; Kondrat, Frances D. L.; Lai, Shuping; Kolander, Kurt D.; Kwok, Wai-Meng; Dai, Qiang; Grzybowski, Michael N.; Zhang, Huali; Taylor, Graydon M.; Lui, Qiang; Thao, Mai T.; Hudson, Judith A.; Barresi, Rita; Bushby, Kate; Jungbluth, Heinz; Wraige, Elizabeth; Geurts, Aron M.; Benesch, Justin L. P.; Riedel, Michael; Christians, Elisabeth S.; Minella, Alex C.; Benjamin, Ivor J.

2016-01-01

Mutations of HSPB5 (also known as CRYAB or αB-crystallin), a bona fide heat shock protein and molecular chaperone encoded by the HSPB5 (crystallin, alpha B) gene, are linked to multisystem disorders featuring variable combinations of cataracts, cardiomyopathy, and skeletal myopathy. This study aimed to investigate the pathological mechanisms involved in an early-onset myofibrillar myopathy manifesting in a child harboring a homozygous recessive mutation in HSPB5, 343delT. To study HSPB5 343delT protein dynamics, we utilize model cell culture systems including induced pluripotent stem cells derived from the 343delT patient (343delT/343delT) along with isogenic, heterozygous, gene-corrected control cells (WT KI/343delT) and BHK21 cells, a cell line lacking endogenous HSPB5 expression. 343delT/343delT and WT KI/343delT-induced pluripotent stem cell-derived skeletal myotubes and cardiomyocytes did not express detectable levels of 343delT protein, contributable to the extreme insolubility of the mutant protein. Overexpression of HSPB5 343delT resulted in insoluble mutant protein aggregates and induction of a cellular stress response. Co-expression of 343delT with WT prevented visible aggregation of 343delT and improved its solubility. Additionally, in vitro refolding of 343delT in the presence of WT rescued its solubility. We demonstrate an interaction between WT and 343delT both in vitro and within cells. These data support a loss-of-function model for the myopathy observed in the patient because the insoluble mutant would be unavailable to perform normal functions of HSPB5, although additional gain-of-function effects of the mutant protein cannot be excluded. Additionally, our data highlight the solubilization of 343delT by WT, concordant with the recessive inheritance of the disease and absence of symptoms in carrier individuals. PMID:27226619

Niebla ceruchis from Laguna Figueroa: dimorphic spore morphology and secondary compounds localized in pycnidia and apothecia

NASA Technical Reports Server (NTRS)

Enzien, M.; Margulis, L.

1988-01-01

During and after the floods of 1979-80 Niebla ceruchis growing epiphytically on Lycium brevipes was one of the dominant aspects of the vegetation in the coastal dunal complex bordering the microbial mats at Laguna Figueroa, Baja California Norte, Mexico. The lichen on denuded branches of Lycium was far more extensively distributed than Lycium lacking lichen. Unusual traits of this Niebla ceruchis strain, namely localization of lichen compounds in the mycobiont reproductive structures (pycnidia and apothecia) and simultaneous presence of bilocular and quadrilocular ascospores, are reported. The abundance of this coastal lichen cover at the microbial mat site has persisted through April 1988.

Proyecto para la medición sistemática de seeing en CASLEO

NASA Astrophysics Data System (ADS)

Fernández Lajus, E.; Forte, J. C.

La calidad del seeing astronómico es ciertamente uno de los parámetros mas importantes que caracterizan el sitio de un observatorio. Por tanto se desea determinar si el alto valor de seeing observado con el telescopio de 2.15 m se debe a efectos internos y/o del entorno a la cupula o si se debe simplemente al seeing propio del lugar. El actual mecanismo de refrigeración del espejo primario del 2.15, parece haber mejorado notablemente la calidad del seeing. Sin embargo se hace necesario saber hasta que punto el valor del seeing puede ser mejorado. La primera etapa del proyecto consistió en la puesta a punto del telescopio emplazado para este propósito y la adquisición de las primeras medidas tentativas de seeing.

Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"

ERIC Educational Resources Information Center

LaGreca, Nancy

2012-01-01

This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

Associations between uncoupling protein 2, body composition, and resting energy expenditure in lean and obese African American, white, and Asian children.

PubMed

Yanovski, J A; Diament, A L; Sovik, K N; Nguyen, T T; Li, H; Sebring, N G; Warden, C H

2000-06-01

Little is known about genes that affect childhood body weight. The objective of this study was to examine the association between alleles of the mitochondrial uncoupling protein 2 (UCP2) gene and obesity because UCP2 may influence energy expenditure. We related UCP2 genotype to body composition and resting energy expenditure in 105 children aged 6-10 y. Overweight children and nonoverweight children of overweight parents were genotyped for a 45-base pair deletion/insertion (del/ins) in 3'-untranslated region of exon 8 and for an exon 4 C to T transition. Eighty-nine children were genotyped for the exon 8 allele: 50 children had del/del, 33 had del/ins, and 6 had ins/ins. Mean (+/-SD) body mass index (BMI; in kg/m(2)) was greater for children with del/ins (24.1 +/- 5.9) than for children with del/del (20.4 +/- 4.8; P < 0.001). BMI of ins/ins children (23.7 +/- 7.8) was not significantly different from that of del/ins children. A greater BMI in del/ins children was independent of race and sex. Body composition was also different according to UCP2 genotype. All body circumferences and skinfold thicknesses examined were significantly greater in del/ins than in del/del children. Body fat mass as determined by dual-energy X-ray absorptiometry was also greater in del/ins than in del/del children (P < 0.005). For 104 children genotyped at exon 4, no significant differences in BMI or body composition were found among the 3 exon 4 genotypes. Neither resting energy expenditure nor respiratory quotient were different according to UCP2 exon 4 or exon 8 genotype. The exon 8 ins/del polymorphism of UCP2 appears to be associated with childhood-onset obesity. The UCP2/UCP3 genetic locus may play a role in childhood body weight.

Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway.

PubMed

Maekawa, Tomoki; Hosur, Kavita; Abe, Toshiharu; Kantarci, Alpdogan; Ziogas, Athanasios; Wang, Baomei; Van Dyke, Thomas E; Chavakis, Triantafyllos; Hajishengallis, George

2015-09-16

Del-1 is an endothelial cell-secreted anti-inflammatory protein. In humans and mice, Del-1 expression is inversely related to that of IL-17, which inhibits Del-1 through hitherto unidentified mechanism(s). Here we show that IL-17 downregulates human endothelial cell expression of Del-1 by targeting a critical transcription factor, C/EBPβ. Specifically, IL-17 causes GSK-3β-dependent phosphorylation of C/EBPβ, which is associated with diminished C/EBPβ binding to the Del-1 promoter and suppressed Del-1 expression. This inhibitory action of IL-17 can be reversed at the GSK-3β level by PI3K/Akt signalling induced by D-resolvins. The biological relevance of this regulatory network is confirmed in a mouse model of inflammatory periodontitis. Intriguingly, resolvin-D1 (RvD1) confers protection against IL-17-driven periodontal bone loss in a Del-1-dependent manner, indicating an RvD1-Del-1 axis against IL-17-induced pathological inflammation. The dissection of signalling pathways regulating Del-1 expression provides potential targets to treat inflammatory diseases associated with diminished Del-1 expression, such as periodontitis and multiple sclerosis.

DEL phenotype.

PubMed

Kwon, Dong H; Sandler, S G; Flegel, Willy A

2017-09-01

DEL red blood cells (RBCs) type as D- by routine serologic methods and are transfused routinely, without being identified as expressing a very weak D antigen, to D- recipients. DEL RBCs are detected only by adsorption and elution of anti-D or by molecular methods. Most DEL phenotypes have been reported in population studies conducted in East Asia, although DEL phenotypes have been detected also among Caucasian individuals. Approximately 98 percent of DEL phenotypes in East Asians are associated with the RHD*DEL1 or RHD*01EL.01 allele. The prevalence of DEL phenotypes has been reported among D- Han Chinese (30%), Japanese (28%), and Korean (17%) populations. The prevalence of DEL phenotypes is significantly lower among D- Caucasian populations (0.1%). Among the 3-5 percent of African individuals who are D-, there are no reports of the DEL phenotype. Case reports from East Asia indicate that transfusion of DEL RBCs to D- recipients has been associated with D alloimmunization. East Asian immigrants constitute 2.1 percent of the 318.9 million persons residing in the United States, and an estimated 2.8 percent are blood donors. Using these statistics, we estimate that 68-683 units of DEL RBCs from donors of East Asian ancestry are transfused as D- annually in the United States. Given the reports from East Asia of D alloimmunization attributed to transfusion of DEL RBCs, one would expect an occasional report of D alloimmunization in the United States following transfusion of DEL RBCs to a D- recipient. If such cases do occur, the most likely reason that they are not detected is the absence of active post-transfusion monitoring for formation of anti-D.

ASSOCIATIONS BETWEEN UNCOUPLING PROTEIN 2, BODY COMPOSITION, AND RESTING ENERGY EXPENDITURE IN LEAN AND OBESE AFRICAN AMERICAN, CAUCASIAN, AND ASIAN CHILDREN

PubMed Central

Yanovski, J.A.; Diament, A.L.; Sovik, K.N.; Nguyen, T.T.; Li, H.; Sebring, N.G.; Warden, C.H.

2015-01-01

Background Little is known about genes affecting childhood body weight. Objective To examine alleles of the mitochondrial uncoupling protein-2 (UCP2) gene for association with obesity, since UCP2 may influence energy expenditure. Design We related UCP2 genotype to body composition, and to resting energy expenditure, in 105 children aged 6–10y. Overweight children and non-overweight children of overweight parents were genotyped for a 45 bp deletion/insertion (del/ins) in 3’ UTR of exon 8 and for an exon 4 C to T transition. Results 89 children were genotyped for the exon 8 allele: 50 children had del/del, 33 del/ins, and 6 ins/ins. Body mass index (BMI) was greater for del/ins (24.1 ± 5.9 kg/m2) than for del/del (20.4 ± 4.8 kg/m2, p<0.001). BMI of ins/ins (23.7 ± 7.8 kg/m2) was not different from del/ins. This effect was independent of race and gender (ANOVAs, p< 0.05). Body composition was also different according to UCP2 genotype. All body circumferences and skin fold thicknesses examined were significantly greater in del/ins than in del/del. DXA body fat mass (p<0.005) was also greater in del/ins than del/del. For 104 children genotyped at exon 4, no significant differences in BMI or body composition were found among the three exon 4 genotypes. Neither resting energy expenditure nor respiratory quotient were different according to UCP2 exon 4 or exon 8 genotype. Conclusion The exon 8 ins/del polymorphism of UCP2 appears to be associated with childhood-onset obesity. The UCP2/UCP3 genetic locus may play a role in childhood body weight. PMID:10837279

The novel c.247_249delTTC (p.F83del) GJB2 mutation in a family with prelingual sensorineural deafness.

PubMed

Petersen, Michael B; Grigoriadou, Maria; Koutroumpe, Maria; Kokotas, Haris

2012-07-01

Non-syndromic hearing loss is one of the most common hereditary determined diseases in human, and the disease is a genetically heterogeneous disorder. Mutations in the GJB2 gene, encoding connexin 26 (Cx26), are a major cause of non-syndromic recessive hearing impairment in many countries and are largely dependent on ethnic groups. Due to the high frequency of the c.35delG GJB2 mutation in the Greek population, we have previously suggested that Greek patients with sensorineural, non-syndromic deafness should be tested for the c.35delG mutation and the coding region of the GJB2 gene should be sequenced in c.35delG heterozygotes. Here we present on the clinical and molecular genetic evaluation of a family suffering from prelingual, sensorineural, non-syndromic deafness. A novel c.247_249delTTC (p.F83del) GJB2 mutation was detected in compound heterozygosity with the c.35delG GJB2 mutation in the proband and was later confirmed in the father, while the mother was homozygous for the c.35delG GJB2 mutation. We conclude that compound heterozygosity of the novel c.247_249delTTC (p.F83del) and the c.35delG mutations in the GJB2 gene was the cause of deafness in the proband and his father. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

A geochemical and geophysical approach to derive a conceptual circulation model of CO2-rich mineral waters: A case study of Vilarelho da Raia, northern Portugal

NASA Astrophysics Data System (ADS)

Marques, J. M.; Santos, Monteiro; Graça, R. C.; Castro, R.; Aires-Barros, L.; Mendes Victor, L. A.

2001-11-01

The Vilarelho da Raia-Chaves region, located in northern Portugal adjacent to the Spanish border, is characterized by both hot and cold CO2-rich mineral waters issuing from springs and drilled wells. The present paper updates the conceptual circulation model of the Vilarelho da Raia cold CO2-rich mineral waters. Vilarelho da Raia mineral waters, dominated by Na and HCO3 ions, have formed mainly by interaction with CO2 of deep-seated mantle origin. The δ18O, δ2H and 3H values indicate that these waters are the result of meteoric waters infiltrating into Larouco Mountain, NW of Vilarelho da Raia, circulating at shallow depths in granitic rocks and moving into Vilarelho da Raia area. The conceptual geochemical and geophysical circulation model indicates that the hot and cold CO2-rich mineral waters of Chaves (76 °C) and Vilarelho da Raia (17 °C) should be considered manifestations of similar but not the same geohydrological systems. Résumé. La région de Vilarelho da Raia - Chaves, située au Portugal près de la frontière Espagnole, est caractérisée par des eaux carbogazeuses, chaudes et froides, émergeant à des sources et dans des puits. Ce travail constitue une mise au point du modèle conceptuel de circulation des eaux minérales carbogazeuses froides de Vilarelho da Raia. Les eaux minérales de Vilarelho da Raia, dans lesquelles les ions Na and HCO3 sont dominants, résultent principalement d'interactions avec du CO2 d'origine mantellique. Les δ18O, les δ2H, et les teneurs en 3H indiquent que ces eaux proviennent de l'infiltration d'eaux météoriques dans le Mont Larouco au NW de Vilarelho da Raia, circulant à faible profondeur dans les granites en direction de la région de Vilarelho da Raia. Le modèle de circulation géochimique et géophysique conduit à penser que les eaux minérales carbogazeuses chaudes et froides de Chaves (76 °C) et de Vilarelho da Raia (17 °C) doivent être considérées comme des manifestations de systèmes hydrogéologiques similaires, mais non identiques. Resumen. La región de Vilarelho-Chaves está situada en el Norte de Portugal, junto a la frontera con España. Se caracteriza por la existencia de aguas minerales calientes y frías enriquecidas en CO2, que descargan mediante manantiales y pozos. El artículo tiene como objetivo la actualización del modelo conceptual de flujo de las aguas frías de Vilarelho de Raia, que son ricas en CO2. Dichas aguas se han formado fundamentalmente por la interacción con el CO2 procedente del manto profundo, y son del tipo bicarbonatado sódico. Los valores de δ18O, δ2H y 3H indican que proceden de la infiltración de agua meteórica en la Montaña Larouco -al Noroeste de Vilarelho de Raia-, que circulan a poca profundidad en un medio formado por de rocas graníticas y se mueven hacia el área de Vilarelho de Raia. El modelo conceptual de flujo, basado en datos geoquímicos y geofísicos, indica que las aguas minerales calientes de Chaves (76 °C) y las frías de Vilarelho de Raia (17 °C), ambas enriquecidas en CO2, no deben ser consideradas como manifestaciones de un único sistema hidrogeológico, sino de dos similares.

Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades

NASA Astrophysics Data System (ADS)

Cirigliano, D.; Vial, J. C.; Rovira, M.

A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

Del(20q) in patients with chronic lymphocytic leukemia: a therapy-related abnormality involving lymphoid or myeloid cells.

PubMed

Yin, C Cameron; Tang, Guilin; Lu, Gary; Feng, Xiaoli; Keating, Michael J; Medeiros, L Jeffrey; Abruzzo, Lynne V

2015-08-01

Deletion 20q (Del(20q)), a common cytogenetic abnormality in myeloid neoplasms, is rare in chronic lymphocytic leukemia. We report 64 patients with chronic lymphocytic leukemia and del(20q), as the sole abnormality in 40, a stemline abnormality in 21, and a secondary abnormality in 3 cases. Fluorescence in situ hybridization (FISH) analysis revealed an additional high-risk abnormality, del(11q) or del(17p), in 25/64 (39%) cases. In most cases, the leukemic cells showed atypical cytologic features, unmutated IGHV (immunoglobulin heavy-chain variable region) genes, and ZAP70 positivity. The del(20q) was detected only after chemotherapy in all 27 cases with initial karyotypes available. With a median follow-up of 90 months, 30 patients (47%) died, most as a direct consequence of chronic lymphocytic leukemia. Eight patients developed a therapy-related myeloid neoplasm, seven with a complex karyotype. Combined morphologic and FISH analysis for del(20q) performed in 12 cases without morphologic evidence of a myeloid neoplasm localized the del(20q) to the chronic lymphocytic leukemia cells in 5 (42%) cases, and to myeloid/erythroid cells in 7 (58)% cases. The del(20q) was detected in myeloid cells in all 4 cases of myelodysplastic syndrome. In aggregate, these data indicate that chronic lymphocytic leukemia with del(20q) acquired after therapy is heterogeneous. In cases with morphologic evidence of dysplasia, the del(20q) likely resides in the myeloid lineage. However, in cases without morphologic evidence of dysplasia, the del(20q) may represent clonal evolution and disease progression. Combining morphologic analysis with FISH for del(20q) or performing FISH on immunomagnetically selected sub-populations to localize the cell population with this abnormality may help guide patient management.

Del(20q) in patients with chronic lymphocytic leukemia: A therapy-related abnormality involving lymphoid or myeloid cells

PubMed Central

Yin, C. Cameron; Tang, Guilin; Lu, Gary; Feng, Xiaoli; Keating, Michael J.; Medeiros, L. Jeffrey; Abruzzo, Lynne V.

2015-01-01

Del(20q), a common cytogenetic abnormality in myeloid neoplasms, is rare in chronic lymphocytic leukemia. We report 64 patients with chronic lymphocytic leukemia and del(20q), as the sole abnormality in 40, a stemline abnormality in 21, and a secondary abnormality in 3 cases. FISH analysis revealed an additional high-risk abnormality, del(11q) or del(17p), in 27/64 (42%) cases. In most cases, the leukemic cells showed atypical cytologic features, unmutated IGHV genes and ZAP70 positivity. The del(20q) was detected only after chemotherapy in all 27 cases with initial karyotypes available. With a median follow-up of 90 months, 30 patients (47%) died, most as a direct consequence of chronic lymphocytic leukemia. Eight patients developed a therapy-related myeloid neoplasm, seven with a complex karyotype. Combined morphologic and FISH analysis for del(20q) performed in 12 cases without morphologic evidence of a myeloid neoplasm localized the del(20q) to the chronic lymphocytic leukemia cells in 5 (42%) cases, and to myeloid/erythroid cells in 7 (58)% cases. The del(20q) was detected in myeloid cells in all 4 cases of myelodysplastic syndrome. In aggregate, these data indicate that chronic lymphocytic leukemia with del(20q) acquired after therapy is heterogeneous. In cases with morphologic evidence of dysplasia, the del(20q) likely resides in the myeloid lineage. However, in cases without morphologic evidence of dysplasia, the del(20q) may represent clonal evolution and disease progression. Combining morphologic analysis with FISH for del(20q) or performing FISH on immunomagnetically-selected subpopulations to localize the cell population with this abnormality may help guide patient management. PMID:25953391

Increasing Naval Security Cooperation between the U.S., Chile and Peru

DTIC Science & Technology

2009-03-01

del Mar: La Marina de Guerra en la historia del Perú (Lima: Marina de Guerra del Perú, 1994), 184. 108 Ibid., 188. 109 Ibid., 191-193. 42 “the...La Marina de Guerra en la historia del Perú, 205. 111 Ibid. 112 Ibid., 210. 113 Ibid., 229. 114 Ibid., 230. 115 Ibid., 246. 43 contributed to...la Puente Brunke, Los Hombres del Mar: La Marina de Guerra en la historia del Perú, 252. 117 Ibid., 264. 118 Ibid., 302. 119 Ibid., 342. 44

Del-1 Expression as a Potential Biomarker in Triple-Negative Early Breast Cancer.

PubMed

Lee, Soo Jung; Lee, Jeeyeon; Kim, Wan Wook; Jung, Jin Hyang; Park, Ho Yong; Park, Ji-Young; Chae, Yee Soo

2018-01-01

A differential diagnostic role for plasma Del-1 was proposed for early breast cancer (EBC) in our previous study. We examined tumoral Del-1 expression and analyzed its prognostic impact among patients with EBC. Del-1 mRNA expression was assessed in breast epithelial and cancer cells. Meanwhile, the tumoral expression of Del-1 was determined based on tissue microarrays and immunohistochemistry results from 440 patients. While a high Del-1 mRNA expression was found in all the breast cancer cell lines, the expression was significantly higher in MDA-MB-231. Tumoral expression of Del-1 was also significantly associated with a negative expression of estrogen receptor or progesterone receptor, and low expression of Ki-67, particularly in the case of triple-negative breast cancer (TNBC) (p < 0.036). Furthermore, a correlation was found between Del-1 expression and an aggressive histological grade, nuclear mitosis, and polymorphism, suggesting a possible role in tumor progression. In the survival analysis, a worse distant disease-free survival trend was noted for the group overexpressing Del-1. While all the investigated breast cancer cell lines exhibited Del-1 expression, the expression rate and intensity were specifically prominent in TNBC. In addition, based on its relationship to an unfavorable histology and worse survival trend, Del-1 could act as a molecular target in TNBC patients. © 2018 S. Karger AG, Basel.

Characteristics and outcome of myelodysplastic syndromes (MDS) with isolated 20q deletion: a report on 62 cases.

PubMed

Braun, Thorsten; de Botton, Stéphane; Taksin, Anne-Laure; Park, Sophie; Beyne-Rauzy, Odile; Coiteux, Valérie; Sapena, Rosa; Lazareth, Anne; Leroux, Geneviève; Guenda, Khaled; Cassinat, Bruno; Fontenay, Michaela; Vey, Norbert; Guerci, Agnès; Dreyfus, François; Bordessoule, Dominique; Stamatoullas, Aspasia; Castaigne, Sylvie; Terré, Christine; Eclache, Virginie; Fenaux, Pierre; Adès, Lionel

2011-07-01

Isolated 20q deletion is common in MDS and considered of good prognosis, but no large series have been reported. We compared characteristics of 62 MDS patients with isolated del 20q, 36 patients with del 20q and other cytogenetic abnormalities, and 1335 MDS patients without del20q. Significant differences between MDS with isolated del 20q and patients without del 20q were lower platelet count (mean 144 vs. 196 G/l, p=0.005), lower marrow blast count (mean 3.9% vs. 5.6%, p=0.0008), and higher reticulocyte count (mean 72.5 vs. 51.7 G/l, p=0.04). Ten (16%) patients with isolated del 20q had Hb>12 g/dl and platelets <100 G/l, compared to 7.3% of patients without del 20q (p=0.025). Review of marrow slides of those 10 patients showed that could be readily identified as MDS prior to cytogenetics. Fourteen percent of patients with isolated del 20q progressed to AML compared to 11% with one and 24% with several additional abnormalities. Median survival was 54 months in patients with isolated del 20q, not reached and 12 months for del 20q with one and several additional abnormalities, respectively (p=0.035) confirming the favorable prognosis of del 20q without complex abnormalities. Copyright © 2011 Elsevier Ltd. All rights reserved.

Produccion Gaseosa del Cometa Halley: Erupciones Y Fotodisociacion del Radical OH

NASA Astrophysics Data System (ADS)

Silva, A. M.; Mirabel, I. F.

1990-11-01

RESUMEN:En este trabajo informamos la detecci6n de 20 erupciones en la li'nea de =18cm (1667MHz) del radical OH en el Cometa Halley.Las observaciones incluyen todos los monitoreos existentes y se extienden desde 120 dias antes del perihelio hasta 90 dias despues.Se detectan bruscos crecimientos en el flujo medido,hasta un factor 1O,seguidos por decaimientos lentos asociados con la fotodisociaci6n del OH. Se obtuvieron valores para el tiempo de vida fotoquimico del OH y del H2O basandose en el modelo desarrollado previamente por Silva(1988). Esos tiempos de vida estan de acuerdo con predicciones teoricas y con las observaciones en el Ultravioleta, y los resultados, los que son fuertemente dependientes de la velocidad heliocentrica del Coineta (variando hasta un factor 6), han sido calculados para varios rangos de velocidad entre +28 y -28 km/seg. Key wo'L :

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Seung-Hwan; Kim, Dong-Young; Jing, Feifeng

Developmental endothelial locus-1 (Del-1) is an endogenous anti-inflammatory molecule that is highly expressed in the lung and the brain and limits leukocyte migration to these tissues. We previously reported that the expression of Del-1 is positively regulated by p53 in lung endothelial cells. Although several reports have implicated the altered expression of Del-1 gene in cancer patients, little is known about its role in tumor cells. We here investigated the effect of Del-1 on the features of human lung carcinoma cells. Del-1 mRNA was found to be significantly decreased in the human lung adenocarcinoma cell lines A549 (containing wild typemore » of p53), H1299 (null for p53) and EKVX (mutant p53), compared to in human normal lung epithelial BEAS-2B cells and MRC-5 fibroblasts. The decrease of Del-1 expression was dependent on the p53 activity in the cell lines, but not on the expression of p53. Neither treatment with recombinant human Del-1 protein nor the introduction of adenovirus expressing Del-1 altered the expression of the apoptosis regulators BAX, PUMA and Bcl-2. Unexpectedly, the adenovirus-mediated overexpression of Del-1 gene into the lung carcinoma cell lines promoted proliferation and invasion of the lung carcinoma cells, as revealed by BrdU incorporation and transwell invasion assays, respectively. In addition, overexpression of the Del-1 gene enhanced features of epithelial–mesenchymal transition (EMT), such as increasing vimentin while decreasing E-cadherin in A549 cells, and increases in the level of Slug, an EMT-associated transcription regulator. Our findings demonstrated for the first time that there are deleterious effects of high levels of Del-1 in lung carcinoma cells, and suggest that Del-1 may be used as a diagnostic or prognostic marker for cancer progression, and as a novel therapeutic target for lung carcinoma. - Highlights: • Developmental Endothelial Locus-1 (Del-1) expression is downregulated in human lung cancer cells. • Overexpression of the Del-1 gene potentiates proliferation and invasion of lung carcinoma cells. • Del-1 may be used as a diagnostic or prognostic marker for lung cancer progression.« less

Endogenous developmental endothelial locus-1 limits ischemia-related angiogenesis by blocking inflammation

PubMed Central

Klotzsche - von Ameln, Anne; Cremer, Sebastian; Hoffmann, Jedrzej; Schuster, Peggy; Khedr, Sherif; Korovina, Irina; Troulinaki, Maria; Neuwirth, Ales; Sprott, David; Chatzigeorgiou, Antonios; Economopoulou, Matina; Orlandi, Alessia; Hain, Andreas; Zeiher, Andreas M.; Deussen, Andreas; Hajishengallis, George; Dimmeler, Stefanie; Chavakis, Triantafyllos; Chavakis, Emmanouil

2017-01-01

We have recently identified endothelial cell-secreted developmental endothelial locus-1 (Del-1) as an endogenous inhibitor of β2-integrin–dependent leukocyte infiltration. Del-1 was previously also implicated in angiogenesis. Here, we addressed the role of endogenously produced Del-1 in ischemia-related angiogenesis. Intriguingly, Del-1–deficient mice displayed increased neovascularization in two independent ischemic models (retinopathy of prematurity and hind-limb ischemia), as compared to Del-1–proficient mice. On the contrary, angiogenic sprouting in vitro or ex vivo (aortic ring assay) and physiological developmental retina angiogenesis were not affected by Del-1 deficiency. Mechanistically, the enhanced ischemic neovascularization in Del-1-deficiency was linked to higher infiltration of the ischemic tissue by CD45+ hematopoietic and immune cells. Moreover, Del-1-deficiency promoted β2-integrin–dependent adhesion of hematopoietic cells to endothelial cells in vitro, and the homing of hematopoietic progenitor cells and of immune cell populations to ischemic muscles in vivo. Consistently, the increased hind limb ischemia-related angiogenesis in Del-1 deficiency was completely reversed in mice lacking both Del-1 and the β2-integrin LFA-1. Additionally, enhanced retinopathy-associated neovascularization in Del-deficient mice was reversed by LFA-1 blockade. Our data reveal a hitherto unrecognized function of endogenous Del-1 as a local inhibitor of ischemia-induced angiogenesis by restraining LFA-1–dependent homing of pro-angiogenic hematopoietic cells to ischemic tissues. Our findings are relevant for the optimization of therapeutic approaches in the context of ischemic diseases. PMID:28447099

Acerca del moho

EPA Pesticide Factsheets

El moho forma parte del medio ambiente natural. Afuera del hogar, el moho juega un papel en la naturaleza al desintegrar materias organicas tales como las hojas que se han caido o los arboles muertos. El moho puede crecer adentro del hogar cuando las espor

Misura de Massa e Larghezza degli Stati $$x_1$$ e $$x_2$$ del Charmonio Formati in Interazioni $$p - \\bar{p}$$

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pallavicini, Marco

1995-01-01

Oggetto di questa tesi è la misura di alcune caratteristiche fisiche ( massa, larghezza, e larghezza parziale in p - p) degli stati 3 Pi e 3 A del charmonio, - overo del sistema legato di un quark "charm" e del suo antiquark-, nell'ambito dell'esperimento E-760, installato nell'accumulatore di antiprotoni del Fermilab (U.S.A).

Dissection of Insertion–Deletion Variants within Differentially Expressed Genes Involved in Wood Formation in Populus

PubMed Central

Gong, Chenrui; Du, Qingzhang; Xie, Jianbo; Quan, Mingyang; Chen, Beibei; Zhang, Deqiang

2018-01-01

Short insertions and deletions (InDels) are one of the major genetic variants and are distributed widely across the genome; however, few investigations of InDels have been conducted in long-lived perennial plants. Here, we employed a combination of RNA-seq and population resequencing to identify InDels within differentially expressed (DE) genes underlying wood formation in a natural population of Populus tomentosa (435 individuals) and utilized InDel-based association mapping to detect the causal variants under additive, dominance, and epistasis underlying growth and wood properties. In the present paper, 5,482 InDels detected from 629 DE genes showed uneven distributions throughout all 19 chromosomes, and 95.9% of these loci were diallelic InDels. Seventy-four InDels (positive false discovery rate q ≤ 0.10) from 68 genes exhibited significant additive/dominant effects on 10 growth and wood-properties, with an average of 14.7% phenotypic variance explained. Potential pleiotropy was observed in one-third of the InDels (representing 24 genes). Seven genes exhibited significantly differential expression among the genotypic classes of associated InDels, indicating possible important roles for these InDels. Epistasis analysis showed that overlapping interacting genes formed unique interconnected networks for each trait, supporting the putative biochemical links that control quantitative traits. Therefore, the identification and utilization of InDels in trees will be recognized as an effective marker system for molecular marker-assisted breeding applications, and further facilitate our understanding of quantitative genomics. PMID:29403506

Radio-Observaciones del OH EN la Coma del Cometa Halley Desde EL Hemisferio Sur

NASA Astrophysics Data System (ADS)

Silva, A. M.; Bajaja, E.; Morras, R.; Cersosimo, J. C.; Martin, M. C.; Arnal, E. M.; Poppel, W. G. L.; Colomb, F. R.; Mazzaro, J.; Olalde, J. C.; Boriakoff, V.; Mirabel, I. F.

1987-05-01

Se utilizó una antena de 30 metros del Instituto Argentino de Radioastronomía para observaciones diarias Cf ebrero a abril de 1986) de la transición en 1667 MHz ( λ = 18 cm) del OH en la coma del cometa Halley. De las observaciones realizadas se concluye: 1) El número promedio de moléculas de OH en la coma durante 37 días de observación fue de (8.9±3.5)x1034 moléculas, lo que implica una tasa de producción promedio de OH de 1.8x1029 moléculas seg-1 y consecuentemente una pérdida de masa promedio de 17±6 toneladas seg-1 . Este valor está de acuerdo con las mediciones realizadas por las sondas Vega y Giotto. 2) El monitoreo desde el lAR revela la existencia de variaciones bruscas en los flujos de absorción del OH. Estas variaciones son consistentes con los modelos que representan la producción gaseosa a partir de ejecciones y/o desprendimientos discretos de materia congelada del núcleo. 3) Las variaciones en la densidad de flujo son consistentes con las estimaciones de los tiem- pos de vida medios del H2O y del OH en presencia del campo de radiación solar. 4) Se encuentra una correlación entre la intensidad del flujo absorbido y anisotropías en Ia dinamica de la coma.

An evaluation of Delaware's DelTrac program : building an integrated transportation management system

DOT National Transportation Integrated Search

2004-06-01

The DelTrac deployment experience included both successes and unmet challenges. Programmatically, the DelTrac approach to managing ITS has been successful at creating a great deal of integration and cooperation between organizations at DelDOT. Stakeh...

An Annotated Bibliography of Latin American Military Journals.

DTIC Science & Technology

1965-12-01

CABALLERIA Y UNIDADES BLINDADAS) REVISTA DE INFANTERIA REVISTA DE INGENIERIA MILITÄR (Organo de la Academia Politecnica Militär) REVISTA DEL...Appendix--continued ■84- PERU BOLETIN DEL MINISTERIO DE GUERRA Y MARINA (Continued as MEMORIAL DEL EJERCITO) INFANTERIA INGENIERIA REVISTA DEL

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells

PubMed Central

Stanton, Bruce A.; Coutermarsh, Bonita; Barnaby, Roxanna; Hogan, Deborah

2015-01-01

Background P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF). Previously, we demonstrated that P. aeruginosa reduced wt-CFTR Cl secretion by airway epithelial cells. Recently, a new investigational drug VX-809 has been shown to increase F508del-CFTR Cl secretion in human bronchial epithelial (HBE) cells, and, in combination with VX-770, to increase FEV1 (forced expiratory volume in 1 second) by an average of 3-5% in CF patients homozygous for the F508del-CFTR mutation. We propose that P. aeruginosa infection of CF lungs reduces VX-809 + VX-770- stimulated F508del-CFTR Cl secretion, and thereby reduces the clinical efficacy of VX-809 + VX-770. Methods and Results F508del-CFBE cells and primary cultures of CF-HBE cells (F508del/F508del) were exposed to VX-809 alone or a combination of VX-809 + VX-770 for 48 hours and the effect of P. aeruginosa on F508del-CFTR Cl secretion was measured in Ussing chambers. The effect of VX-809 on F508del-CFTR abundance was measured by cell surface biotinylation and western blot analysis. PAO1, PA14, PAK and 6 clinical isolates of P. aeruginosa (3 mucoid and 3 non-mucoid) significantly reduced drug stimulated F508del-CFTR Cl secretion, and plasma membrane F508del-CFTR. Conclusion The observation that P. aeruginosa reduces VX-809 and VX-809 + VX-770 stimulated F508del CFTR Cl secretion may explain, in part, why VX-809 + VX-770 has modest efficacy in clinical trials. PMID:26018799

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.

PubMed

Stanton, Bruce A; Coutermarsh, Bonita; Barnaby, Roxanna; Hogan, Deborah

2015-01-01

P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF). Previously, we demonstrated that P. aeruginosa reduced wt-CFTR Cl secretion by airway epithelial cells. Recently, a new investigational drug VX-809 has been shown to increase F508del-CFTR Cl secretion in human bronchial epithelial (HBE) cells, and, in combination with VX-770, to increase FEV1 (forced expiratory volume in 1 second) by an average of 3-5% in CF patients homozygous for the F508del-CFTR mutation. We propose that P. aeruginosa infection of CF lungs reduces VX-809 + VX-770- stimulated F508del-CFTR Cl secretion, and thereby reduces the clinical efficacy of VX-809 + VX-770. F508del-CFBE cells and primary cultures of CF-HBE cells (F508del/F508del) were exposed to VX-809 alone or a combination of VX-809 + VX-770 for 48 hours and the effect of P. aeruginosa on F508del-CFTR Cl secretion was measured in Ussing chambers. The effect of VX-809 on F508del-CFTR abundance was measured by cell surface biotinylation and western blot analysis. PAO1, PA14, PAK and 6 clinical isolates of P. aeruginosa (3 mucoid and 3 non-mucoid) significantly reduced drug stimulated F508del-CFTR Cl secretion, and plasma membrane F508del-CFTR. The observation that P. aeruginosa reduces VX-809 and VX-809 + VX-770 stimulated F508del CFTR Cl secretion may explain, in part, why VX-809 + VX-770 has modest efficacy in clinical trials.

Efectos combinados de la ampliación de la atención primaria de salud y de las transferencias condicionadas de dinero en efectivo sobre la mortalidad infantil en Brasil, 1998–2010*

PubMed Central

Guanais, Frederico C.

2015-01-01

Objetivos. Examiné los efectos combinados del acceso a la atención primaria mediante el Programa de Salud Familiar (PSF) y las transferencias condicionadas de dinero en efectivo del Programa Bolsa Familia (PBF) sobre la mortalidad infantil posneonatal (MIPN) en Brasil. Métodos. Empleé un análisis ecológico longitudinal usando datos en panel de 4 583 municipios brasileños de 1998 al 2010, con 54 253 observaciones en total. Estimé modelos de regresión de efectos fijos por mínimos cuadrados ordinarios, con la tasa de MIPN como la variable dependiente y el PSF, el PBF y sus interacciones como las principales variables independientes de interés. Resultados. La asociación de una mayor cobertura del PSF con una menor tasa de MIPN se volvió más fuerte conforme aumentaba la cobertura del PBF. En los promedios de todas las demás variables, cuando la cobertura de PBF era 25%, la MIPN predicha fue 5,24 (intervalo de confianza [IC] de 95% = 4,95, 5,53) para una cobertura del PSF de 0%, y de 3,54 (IC de 95% = 2,77, 4,31) para una cobertura del PSF de 100%. Cuando la cobertura del PBF era de 60%, la MIPN predicha fue 4,65 (IC de 95% = 4,36, 4,94) para una cobertura del PSF de 0%, y de 1,38 (IC de 95% = 0,88, 1,89) para una cobertura del PSF de 100%. Conclusiones. El efecto del PSF depende de la ampliación del PBF. Para las poblaciones empobrecidas y subatendidas, la combinación de intervenciones tanto del lado de la oferta como del lado de la demanda podría ser necesaria para mejorar los resultados en salud.

Analisis del contenido curricular de los Documentos Normativos del Programa de Ciencias en el area de biologia para la escuela superior del sistema de educacion publica de Puerto Rico: 1993-2012

NASA Astrophysics Data System (ADS)

Davila Montanez, Melissa

Esta investigacion de naturaleza cualitativa se ocupo de realizar un analisis de contenido documental de los Documentos Normativos del Programa de Ciencias en el area de biologia de la escuela superior del sistema de educacion publica de Puerto Rico del periodo 1993-2012. Los documentos analizados fueron: Guia Curricular, 1995; Marco Curricular, 2003; Estandares de Excelencia, 1996, 2000 y Estandares de Contenido y Expectativas de Grado, 2007. Se indago si hubo cambios en significados en los Componentes Estructurales: Naturaleza de la ciencia, Paradigmas para la ensenanza de la ciencia, Funcion del curriculo formal, Mision de la ensenanza de la ciencia; Contenidos, destrezas y competencias, Estrategias de ensenanza y Evaluacion/Assessment del aprendizaje. El analisis sugiere que no hubo cambios sustanciales en los significados de los Componentes Estructurales. Los documentos estudiados muestran mayormente caracteristicas similares, aunque los documentos mas recientes eran mas descriptivos, explicativos y especificos.

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.

PubMed

Chung, W Joon; Goeckeler-Fried, Jennifer L; Havasi, Viktoria; Chiang, Annette; Rowe, Steven M; Plyler, Zackery E; Hong, Jeong S; Mazur, Marina; Piazza, Gary A; Keeton, Adam B; White, E Lucile; Rasmussen, Lynn; Weissman, Allan M; Denny, R Aldrin; Brodsky, Jeffrey L; Sorscher, Eric J

2016-01-01

Small molecules that correct the folding defects and enhance surface localization of the F508del mutation in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) comprise an important therapeutic strategy for cystic fibrosis lung disease. However, compounds that rescue the F508del mutant protein to wild type (WT) levels have not been identified. In this report, we consider obstacles to obtaining robust and therapeutically relevant levels of F508del CFTR. For example, markedly diminished steady state amounts of F508del CFTR compared to WT CFTR are present in recombinant bronchial epithelial cell lines, even when much higher levels of mutant transcript are present. In human primary airway cells, the paucity of Band B F508del is even more pronounced, although F508del and WT mRNA concentrations are comparable. Therefore, to augment levels of "repairable" F508del CFTR and identify small molecules that then correct this pool, we developed compound library screening protocols based on automated protein detection. First, cell-based imaging measurements were used to semi-quantitatively estimate distribution of F508del CFTR by high content analysis of two-dimensional images. We evaluated ~2,000 known bioactive compounds from the NIH Roadmap Molecular Libraries Small Molecule Repository in a pilot screen and identified agents that increase the F508del protein pool. Second, we analyzed ~10,000 compounds representing diverse chemical scaffolds for effects on total CFTR expression using a multi-plate fluorescence protocol and describe compounds that promote F508del maturation. Together, our findings demonstrate proof of principle that agents identified in this fashion can augment the level of endoplasmic reticulum (ER) resident "Band B" F508del CFTR suitable for pharmacologic correction. As further evidence in support of this strategy, PYR-41-a compound that inhibits the E1 ubiquitin activating enzyme-was shown to synergistically enhance F508del rescue by C18, a small molecule corrector. Our combined results indicate that increasing the levels of ER-localized CFTR available for repair provides a novel route to correct F508del CFTR.

An experiment of formation of charmoni states in annihilation P-Pbarra. Un esperimento di formazione di stati del charmonio in annichilazione P-Pbarra (in Italian)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pallavicini, Marco

1995-01-01

Oggetto di questa tesi e la misura di alcune caratteristiche fisiche (massa, larghezza, e larghezza parziale in p -more » $$\\bar{p}$$) degli stati 3P 1 e 3P 2 del charmonio, -ovvero del sistema legato di un quark "charm" e del suo antiquark-, nell'amito dell'esperimento E-760, installato nell'accumulatore di antiprotoni del Fermilab.« less

Regulation and Function of TIFAB in Myelodysplastic Syndrome

DTIC Science & Technology

2013-06-01

genomic alteration in MDS is deletion of chromosome 5q (del(5q)). MDS patients with an isolated del(5q) presenting with anemia, neutropenia , and...is deletion of chromosome 5q (del(5q)). MDS patients with an isolated del(5q) presenting with anemia, neutropenia , and elevated platelets associated

Landscape connectivity among remnant populations of guanaco (Lama guanicoe Müller, 1776) in an arid region of Chile impacted by global change

PubMed Central

Espinosa, Mara I.; Gouin, Nicolas; Squeo, Francisco A.; López, David

2018-01-01

Connectivity between populations plays a key role in the long-term persistence of species in fragmented habitats. This is of particular concern for biodiversity preservation in drylands, since water limited landscapes are typically characterized by little suitable habitat cover, high habitat fragmentation, harsh matrices, and are being rapidly degraded at a global scale. In this study, we modelled landscape connectivity between 11 guanaco Lama guanicoe populations in Chile’s arid Norte Chico, a region that supports the last remnant coastal populations of this emblematic herbivore indigenous to South America. We produced a habitat suitability model to derive a regional surface resistance map, and used circuit theory to map functional connectivity, investigate the relative isolation between populations, and identify those that contribute most to the patch connectivity network. Predicted suitable habitat for L. guanicoe represented about 25% of the study region (i.e., 29,173 km2) and was heterogeneously distributed along a continuous stretch along the Andes, and discontinuous patches along the coast. As a result, we found that high connectivity current flows in the mid and high Andes formed a wide, continuous connectivity corridor, enabling connectivity between all high Andean populations. Coastal populations, in contrast, were more isolated. These groups demonstrate no inter-population connectivity between themselves, only with higher altitude populations, and for two of them, animal movement was linked to the effectiveness of wildlife crossings along the Pan-American highway. Our results indicate that functional connectivity is an issue of concern for L. guanicoe in Chile’s Norte Chico, implying that future conservation and management plans should emphasize strategies aimed at conserving functional connectivity between coastal and Andean populations, as well as the protection of habitat patches likely to act as stepping stones within the connectivity network. PMID:29507827

Modeling the Crust and Upper Mantle in Northern Beata Ridge (CARIBE NORTE Project)

NASA Astrophysics Data System (ADS)

Núñez, Diana; Córdoba, Diego; Cotilla, Mario Octavio; Pazos, Antonio

2016-05-01

The complex tectonic region of NE Caribbean, where Hispaniola and Puerto Rico are located, is bordered by subduction zone with oblique convergence in the north and by incipient subduction zone associated to Muertos Trough in the south. Central Caribbean basin is characterized by the presence of a prominent topographic structure known as Beata Ridge, whose oceanic crustal thickness is unusual. The northern part of Beata Ridge is colliding with the central part of Hispaniola along a transverse NE alignment, which constitutes a morphostructural limit, thus producing the interruption of the Cibao Valley and the divergence of the rivers and basins in opposite directions. The direction of this alignment coincides with the discontinuity that could explain the extreme difference between west and east seismicity of the island. Different studies have provided information about Beata Ridge, mainly about the shallow structure from MCS data. In this work, CARIBE NORTE (2009) wide-angle seismic data are analyzed along a WNW-ESE trending line in the northern flank of Beata Ridge, providing a complete tectonic view about shallow, middle and deep structures. The results show clear tectonic differences between west and east separated by Beata Island. In the Haiti Basin area, sedimentary cover is strongly influenced by the bathymetry and its thickness decreases toward to the island. In this area, the Upper Mantle reaches 20 km deep increasing up to 24 km below the island where the sedimentary cover disappears. To the east, the three seamounts of Beata Ridge provoke the appearance of a structure completely different where sedimentary cover reaches thicknesses of 4 km between seamounts and Moho rises up to 13 km deep. This study has allowed to determine the Moho topography and to characterize seismically the first upper mantle layers along the northern Beata Ridge, which had not been possible with previous MCS data.

Fluctuations of Glaciar Esperanza Norte in the North Patagonian Andes of Argentina during the past 400 yr

NASA Astrophysics Data System (ADS)

Ruiz, L.; Masiokas, M. H.; Villalba, R.

2011-11-01

The number of studies of Little Ice Age (LIA) glacier fluctuations in Southern South America has increased in recent years but is largely biased towards sites in the South Patagonian Andes. In this paper we present a detailed record of length and areal fluctuations of Glaciar Esperanza Norte (GEN), in the North Patagonian Andes of Argentina, during the past four centuries. The GEN record was reconstructed through the dendro-geomorphological dating of moraines and the analysis of satellite imagery, aerial photographs and documentary material complemented with extensive field surveys. The maximum LIA extent at GEN was associated with an outer moraine dated to the mid 17th century. At least 19 subsequent readvances or standstills evidenced by morainic ridges were identified inside the most extensive LIA moraine. The dating and spacing of these moraines and the additional information available indicate that the ice front retreated much more rapidly during the 20th century than during earlier centuries. Comparison with the record of LIA fluctuations of Glaciar Frías, an ice mass of similar characteristics located 110 km to the north of GEN, shows a similar pattern of recession over the past 400 yr. Both glacier records have the peak LIA event occurring roughly during the same interval and show a minor readvance during the 1970s, but there are still a few discrepancies in the dating of some inner moraines. These differences may be due to local, specific factors or associated with the inherent uncertainties in the dating of the moraines. The chronologies of GEN and Frías are among the most detailed currently available in Patagonia, but a larger number of study sites is needed to develop robust, regionally representative glacier chronologies. Detailed glaciological, geomorphological and meteorological data are also needed to understand the glacier-climate relationships in this region and develop reliable paleoclimatic reconstructions.

Fluctuations of Glaciar Esperanza Norte in the north Patagonian Andes of Argentina during the past 400 yr

NASA Astrophysics Data System (ADS)

Ruiz, L.; Masiokas, M. H.; Villalba, R.

2012-06-01

The number of studies of Little Ice Age (LIA) glacier fluctuations in southern South America has increased in recent years but is largely biased towards sites in the south Patagonian Andes. In this paper we present a detailed record of length and areal fluctuations of Glaciar Esperanza Norte (GEN) in the north Patagonian Andes of Argentina during the past four centuries. The GEN record was reconstructed through the dendro-geomorphological dating of moraines and the analysis of satellite imagery, aerial photographs and documentary material complemented with extensive field surveys. The maximum LIA extent at GEN was associated with an outer moraine dated to the mid 17th century. At least 19 subsequent readvances or standstills evidenced by morainic ridges were identified inside the most extensive LIA moraine. The dating and spacing of these moraines and the additional information available indicate that the ice front retreated much more rapidly during the 20th century than during earlier centuries. Comparison with the record of LIA fluctuations of Glaciar Frías, an ice mass of similar characteristics located 110 km to the north of GEN, shows a similar pattern of recession over the past 400 yr. Both glacier records have the peak LIA event occurring roughly during the same interval (early-mid 17th century) and show a minor readvance during the 1970s, but there are still a few discrepancies in the dating of some inner moraines. These differences may be due to local, specific factors or associated with the inherent uncertainties in the dating of the moraines. The chronologies of GEN and Frías are among the most detailed currently available in Patagonia, but a larger number of study sites is needed to develop robust, regionally representative glacier chronologies. Detailed glaciological, geomorphological and meteorological data are also needed to understand the glacier-climate relationships in this region and develop reliable paleoclimatic reconstructions.

Blonanserin Ameliorates Phencyclidine-Induced Visual-Recognition Memory Deficits: the Complex Mechanism of Blonanserin Action Involving D3-5-HT2A and D1-NMDA Receptors in the mPFC

PubMed Central

Hida, Hirotake; Mouri, Akihiro; Mori, Kentaro; Matsumoto, Yurie; Seki, Takeshi; Taniguchi, Masayuki; Yamada, Kiyofumi; Iwamoto, Kunihiro; Ozaki, Norio; Nabeshima, Toshitaka; Noda, Yukihiro

2015-01-01

Blonanserin differs from currently used serotonin 5-HT2A/dopamine-D2 receptor antagonists in that it exhibits higher affinity for dopamine-D2/3 receptors than for serotonin 5-HT2A receptors. We investigated the involvement of dopamine-D3 receptors in the effects of blonanserin on cognitive impairment in an animal model of schizophrenia. We also sought to elucidate the molecular mechanism underlying this involvement. Blonanserin, as well as olanzapine, significantly ameliorated phencyclidine (PCP)-induced impairment of visual-recognition memory, as demonstrated by the novel-object recognition test (NORT) and increased extracellular dopamine levels in the medial prefrontal cortex (mPFC). With blonanserin, both of these effects were antagonized by DOI (a serotonin 5-HT2A receptor agonist) and 7-OH-DPAT (a dopamine-D3 receptor agonist), whereas the effects of olanzapine were antagonized by DOI but not by 7-OH-DPAT. The ameliorating effect was also antagonized by SCH23390 (a dopamine-D1 receptor antagonist) and H-89 (a protein kinase A (PKA) inhibitor). Blonanserin significantly remediated the decrease in phosphorylation levels of PKA at Thr197 and of NR1 (an essential subunit of N-methyl-D-aspartate (NMDA) receptors) at Ser897 by PKA in the mPFC after a NORT training session in the PCP-administered mice. There were no differences in the levels of NR1 phosphorylated at Ser896 by PKC in any group. These results suggest that the ameliorating effect of blonanserin on PCP-induced cognitive impairment is associated with indirect functional stimulation of the dopamine-D1-PKA-NMDA receptor pathway following augmentation of dopaminergic neurotransmission due to inhibition of both dopamine-D3 and serotonin 5-HT2A receptors in the mPFC. PMID:25120077

Integrative research identifies 71 new plant species records in the state of Rio Grande do Norte (Brazil) and enhances a small herbarium collection during a funding shortage.

PubMed

Versieux, Leonardo M; Dávila, Nállarett; Delgado, Geadelande C; de Sousa, Valdeci F; de Moura, Edweslley Otaviano; Filgueiras, Tarciso; Alves, Marccus V; Carvalho, Eric; Piotto, Daniel; Forzza, Rafaela C; Calvente, Alice; Jardim, Jomar G

2017-01-01

A National Forest Inventory (NFI) encompassing the entire territory of Brazil is in progress. It is coordinated and promoted by the Brazilian Forest Service of the Ministry of Environment. In each state, the NFI collaborates with local herbaria by receiving collected plant material and performing species identification. Consultants are hired by the NFI and work at the local herbaria under the supervision of a curator. In exchange for curatorial assistance, the NFI provides equipment and consumables for the herbarium. Other public projects collaborating with NFI are Reflora and the Brazilian Biodiversity Information System (SiBBr). Both projects have online platforms that seek to connect herbaria and make all their data freely available, including high quality digital images of specimens. Through inter-institutional collaboration, the joint interests of NFI, Reflora, SiBBr and local herbaria have improved collections, expanded the online Reflora database, and provided the NFI with verified species lists. These strategic uses of public funding are positively affecting Botany, particularly during a period of economic crisis and cuts in research. Here, we illustrate the increase in floristic knowledge through the improvement of a herbarium collection in Rio Grande do Norte (RN) - the Brazilian state with the lowest levels of plant richness. We report 71 new occurrences of vascular plants for RN, belonging mainly to the Poaceae, Fabaceae and Malvaceae. Most of the species with new occurrences have a Neotropical distribution (21 spp.) and only seven are restricted to the Brazilian Northeast. Our findings highlight previous gaps in RN's floristic knowledge. The partnership NFI, Reflora, SiBBr and the UFRN herbarium improved herbarium curation, digital collection, and quality of data. Finally, a fellowship provided by Reflora and SiBBr allowed improving curation by distributing duplicates and incorporating the Herbarium of Câmara Cascudo Museum.

Niche expansion, body size, and survival in Galápagos marine iguanas.

PubMed

Wikelski, M; Wrege, Peter H

2000-07-01

Foraging theory predicts that dietary niche breadth should expand as resource availability decreases. However, Galápagos marine iguanas often die during algae shortages (El Niños) although land plants abound where they rest and reproduce. On Seymour Norte island, a subpopulation of iguanas exhibited unique foraging behavior: they consistently included the succulent beach plant B. maritima in their diet. We investigated the consequences of land-plant feeding for body size and survival. Batis-eaters supplemented their algae diet both before and after intertidal zone foraging, and more Batis was eaten during tides unfavorable for intertidal zone foraging (dawn and dusk). Larger, energy-constrained iguanas fed more on land than did smaller animals. Compared to intertidal zone algae, Batis was 39% lower in caloric content (1.6 vs. 2.6 kcal g -1 dry mass), 56% lower in protein (8.3 vs. 18.9% dry mass) and 57% lower in nitrogen (1.3 vs. 3.0% dry mass). In spite of its lower nutrient value, iguanas that supplemented their diet with this plant were able to attain nearly twice the body size of other iguanas on the island. Age estimates indicate that many Batis-eaters survived repeated El Niño episodes during which animals of their relative size-class experienced high mortality on other islands. The larger animals were, however, completely dependent upon this supplementary source of food to maintain condition, and all perished in the 1997-1998 El Niño when high tides inundated and killed Batis on Seymour Norte Island. We hypothesize that Batis feeding developed as a local foraging tradition, and that dietary conservatism and strong foraging site fidelity explain why the inclusion of land plants in the diet has been observed in only a single population. Ultimately, a unique algae-adapted hindgut morphology and physiology may limit a switch from marine to terrestrial diet.

Integrative research identifies 71 new plant species records in the state of Rio Grande do Norte (Brazil) and enhances a small herbarium collection during a funding shortage

PubMed Central

Versieux, Leonardo M.; Dávila, Nállarett; Delgado, Geadelande C.; de Sousa, Valdeci F.; de Moura, Edweslley Otaviano; Filgueiras, Tarciso; Alves, Marccus V.; Carvalho, Eric; Piotto, Daniel; Forzza, Rafaela C.; Calvente, Alice; Jardim, Jomar G.

2017-01-01

Abstract A National Forest Inventory (NFI) encompassing the entire territory of Brazil is in progress. It is coordinated and promoted by the Brazilian Forest Service of the Ministry of Environment. In each state, the NFI collaborates with local herbaria by receiving collected plant material and performing species identification. Consultants are hired by the NFI and work at the local herbaria under the supervision of a curator. In exchange for curatorial assistance, the NFI provides equipment and consumables for the herbarium. Other public projects collaborating with NFI are Reflora and the Brazilian Biodiversity Information System (SiBBr). Both projects have online platforms that seek to connect herbaria and make all their data freely available, including high quality digital images of specimens. Through inter-institutional collaboration, the joint interests of NFI, Reflora, SiBBr and local herbaria have improved collections, expanded the online Reflora database, and provided the NFI with verified species lists. These strategic uses of public funding are positively affecting Botany, particularly during a period of economic crisis and cuts in research. Here, we illustrate the increase in floristic knowledge through the improvement of a herbarium collection in Rio Grande do Norte (RN) – the Brazilian state with the lowest levels of plant richness. We report 71 new occurrences of vascular plants for RN, belonging mainly to the Poaceae, Fabaceae and Malvaceae. Most of the species with new occurrences have a Neotropical distribution (21 spp.) and only seven are restricted to the Brazilian Northeast. Our findings highlight previous gaps in RN’s floristic knowledge. The partnership NFI, Reflora, SiBBr and the UFRN herbarium improved herbarium curation, digital collection, and quality of data. Finally, a fellowship provided by Reflora and SiBBr allowed improving curation by distributing duplicates and incorporating the Herbarium of Câmara Cascudo Museum. PMID:29033668

Effect of ethanolic extract of Carpolobia lutea G. Don (polygalaceae) root on learning and memory in CD1 mice.

PubMed

Ajiwhen, I O; Bisong, S A

2013-12-20

Carpolobia lutea, commonly called cattle stick or poor man's candle, is used by traditional herbalists in eastern Nigeria to treat 'madness'. It has a reported analgesic and anti-nociceptive effect. The effect of its ethanolic root extract on learning and memory was investigated. Thirty mice were divided into three groups of ten each. One group of mice served as the control and was given normal saline (p.o.) while the other two groups were given acute low dose (1500mg/kg, p.o.) and high dose (2500mg/kg, p.o.) (LD50 3338.83mg/kg). The effect of the extract on cognitive memory was investigated using the Novel Object recognition task (NORT) while the effect on visuospatial learning and memory was studied using the Morris Water maze (MWM). The results obtained in the NORT show that the index of habituation was significantly lower following acute treatment with a low dose of C. lutea extract compared to control. However, the index of habituation did not differ following treatment with a high dose of C. lutea compared to control but it was higher compared to the low dose. Following treatment with a low dose of the extract, the index of discrimination was significantly higher compared to control. The index of discrimination in the high dose treatment group did not differ from control, but it was lower compared to the low dose treatment. This indicated that there was improved cognitive memory only in the low dose treatment group. In the MWM there was no significant difference in swim latency during Acquisition and Reversal training. There also was no significant difference in quadrant duration during probe trial. The swim latency during the visible platform test showed that all mice used had good visual acuity. Therefore, the ethanolic extract of C. lutea root enhanced cognitive memory. However it did not affect visuospatial learning and memory.

Vertical stratification and development aspects of phlebotomine sand flies (Diptera: Psychodidae) in an area of Atlantic Forest tree species in a metropolitan region in northeastern Brazil.

PubMed

Cortez, A M; Silva, V P M; Queiroz, P V S; Andrade, H T A; Loiola, M I B; Ximenes, M F F M

2007-12-01

In the state of Rio Grande do Norte in northeast Brazil, cases of visceral leishmaniasis (VL) occur mainly in the periurban areas of the city of Natal. Lutzomyia longipalpis Lutz & Neiva 1912 (Diptera: Psychodidae), a vector of Leishmania chagasi (Protozoa: Trypanosomatidae) to humans, is found throughout the state. Flora and fauna influence the distribution of sand fly species, whose horizontal or vertical stratification can be used as a parameter for identifying potential vectors, considering the presence of vertebrate hosts in the area. The purpose of this study was to obtain information about the vertical stratification of phlebotomine sand flies in an endemic area of leishmaniasis in Rio Grande do Norte, and associate it with the presence of other animals in the peridomiciliary environment as well as to analyze, under laboratory conditions, aspects of L. longipalpis reproduction in wild females. The sand flies were captured with light traps hung at different heights in species of Atlantic Forest trees and in a peridomiciliary environment in animal shelters. The traps were placed between 17:30 and 6:00 of the following day, in a peridomiciliary and extradomiciliary area of a forest fragment in both dry and rainy months. In the extradomiciliary environment, the traps were installed at 1, 3 and 5 m above the ground. The biological cycle of L. longipalpis was followed from the eggs of 200 wild females. Specimens of L. lenti, L. walkeri, and L. migonei were captured. The comparison and statistical analysis showed that L. longipalpis is more abundant at a height of 3 m and L. evandroi at 1 m. In the animal shelters (chickens, horses, and armadillos), we captured mainly specimens of L. longipalpis and L. evandroi. The duration of the biological cycle of L. longipalpis was approximately 38 days at a temperature of 28 degrees C.

An analysis of the meanings of pre-eclampsia for pregnant and postpartum women and health professionals in Rio Grande do Norte, Brazil.

PubMed

de Azevedo, Daniela Vasconcelos; de Araújo, Ana C P F; Clara Costa, Iris C

2011-12-01

To understand the meanings of pre-eclampsia for pregnant and postpartum women and health-care professionals. a word-association test and semi-structured interviews. A maternity hospital located in Natal, Rio Grande do Norte, Brazil that serves pregnant and postpartum women considered to be at high risk. 51 Pregnant women, 10 postpartum women and 87 health-care professionals completed a word-association test; 18 pregnant women, two postpartum women and 20 health-care professionals for the interviews. Thematic categories based on the word-association test and the interviews were created to help the data analysis. χ(2) test was used to compare the categories raised by both groups in the word-association test to determine the association between the frequencies of these categories. The meanings of pre-eclampsia to pregnant and postpartum women were fear, risk, care and lack of information. To the health-care professionals, the meanings were care, fear, risk, high blood pressure, oedema and proteinuria. The frequencies of the categories 'fear', 'care' and 'risk' were statistically different (χ(2) = 31.84, 14.5, 38.19, respectively; df = 2, p < 0.001) between the group of pregnant and postpartum women and the group of health-care professionals. For the first group, the most significant meanings were fear and risk, compared with care for the second group. The analysis of the interviews confirmed and deepened the results of the word-association test, and also demonstrated that the pregnant and postpartum women had no information about pre-eclampsia. There is a gap between how women and health professionals view their experiences of pre-eclampsia. A warm welcome to the health-care facility, with clear explanations about the disease and the procedures to be performed during the visits and hospitalisation would be important aspects for the physical and mental well-being of pregnant and postpartum women. Copyright © 2010 Elsevier Ltd. All rights reserved.

Repetitive stress leads to impaired cognitive function that is associated with DNA hypomethylation, reduced BDNF and a dysregulated HPA axis.

PubMed

Makhathini, Khayelihle B; Abboussi, Oualid; Stein, Dan J; Mabandla, Musa V; Daniels, William M U

2017-08-01

Exposure to repetitive stress has a negative influence on cognitive-affective functioning, with growing evidence that these effects may be mediated by a dysregulated hypothalamic-pituitary-adrenal (HPA) axis, abnormal neurotrophic factor levels and its subsequent impact on hippocampal function. However, there are few data about the effect of repetitive stressors on epigenetic changes in the hippocampus. In the present study, we examine how repetitive restrain stress (RRS) affects cognitive-affective functioning, HPA axis regulation, brain-derived neurotrophic factor (BDNF) levels, and global hippocampal DNA methylation. RRS was induced in rats by restraining the animals for 6h per day for 28 days. The novel object recognition test (NORT) was used to assess cognitive functioning and the open field test (OFT) was performed to assess anxiety-like behavior during the last week of stress. Hippocampal BDNF levels, glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA were assessed using real-time PCR and confirmed with Western blot, while ELISAs were used to determine plasma corticosterone levels and the global methylation status of the hippocampus. Animals exposed to repetitive stress demonstrated significant alterations in the NORT and OFT, had significantly increased plasma corticosterone and significantly decreased hippocampal BDNF concentrations. The expression levels of GR and MR mRNA and protein levels of these genes were significantly decreased in the stressed group compared to control animals. The global DNA methylation of the hippocampal genome of stressed animals was also significantly decreased compared to controls. The data here are consistent with previous work emphasizing the role of the HPA axis and neurotrophic factors in mediating cognitive-affective changes after exposure to repetitive stressors. Our findings, however, extend the literature by indicating that epigenetic alterations in the hippocampal genome may also play an important role in the development of hippocampus-associated behavioral abnormalities. Copyright © 2017 ISDN. Published by Elsevier Ltd. All rights reserved.

Kurt Gödels Brünner Verwandte

NASA Astrophysics Data System (ADS)

Müller, Dora

2007-11-01

The author of this memoir Dora Müller (born 1920) belongs - as well as Kurt Gödel-to the German minority playing an important role in the past life of Brno. The marriage of his son included her among the Gödels collaterals. She was chemist, but also pianist, historician, participant of antinacist movement and iniciator of Czech-German understanding after war. Following her personal experiences, remembrances of Gödels relatives and documental materials, she evokes the atmosphere of broader family milieu of Kurt Gödel.

Resolving the Orientation of Cylinders and Cuboids from Projected Area Measurements

DTIC Science & Technology

2016-05-01

fabs ( e1 ) + Ay * fabs ( e2...Az * fabs ( e3 ) - A_xy; 90 g = Ax * fabs ( e4 ) + Ay * fabs ( e5 ) + Az * fabs ( e6 ) - A_xz; 91 h = Ax * fabs ( e7 ) + Ay * fabs ( e8 ) + Az * fabs ( e9...b23 * h; 128 del_r = b31 * f + b32 * g + b33 * h; 129 130 p -= del_p; 131 y -= del_y; 132 r -= del_r; 133 134 if ( fabs ( del_p ) < TOL && fabs (

Systematically frameshifting by deletion of every 4th or 4th and 5th nucleotides during mitochondrial transcription: RNA self-hybridization regulates delRNA expression.

PubMed

Seligmann, Hervé

2016-01-01

In mitochondria, secondary structures punctuate post-transcriptional RNA processing. Recently described transcripts match the human mitogenome after systematic deletions of every 4th, respectively every 4th and 5th nucleotides, called delRNAs. Here I explore predicted stem-loop hairpin formation by delRNAs, and their associations with delRNA transcription and detected peptides matching their translation. Despite missing 25, respectively 40% of the nucleotides in the original sequence, del-transformed sequences form significantly more secondary structures than corresponding randomly shuffled sequences, indicating biological function, independently of, and in combination with, previously detected delRNA and thereof translated peptides. Self-hybridization decreases delRNA abundances, indicating downregulation. Systematic deletions of the human mitogenome reveal new, unsuspected coding and structural informations. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The Morphologic Evolution of the Amazon Coastal Plain, Cabo Norte, Amapa, Brazil: The Need for Integrated Investigation on the Internal Continental Shelf.

NASA Astrophysics Data System (ADS)

Silveira, O.; Santos, V. F.; Takiyama, L. R.

2007-05-01

The north brazilian coastal region is submitted to the conjunction of three major forcing: 1) Atmospheric, related to the wind and precipitation regimen and controlling the climatic seasonality and the local rivers hydrology; 2) Oceanic, result of the general oceanic circulation (North Equatorial Current-NEC) and it modulation with the atmospheric forcing (North Brazilian Coastal Current reflection), and 3) Amazonic, which is a result of the sedimentary transport from Amazon river, being itself under the influence of the atmospheric and oceanic forcing. Their main characteristic are the proper periodicities and also variabilities expressed according multiples and differentiated scales of time and space, determining the structure and functioning of the coastal space, giving to the Amazon coast line a considerable environmental instability. The Amapa Coastal Plain shows important part of this environmental instability. Semidiurnal macro tides, strong currents and tidal bores acts over a low gradient coastal plain which evolutionary process are intrinsically related with tectonic and geological settings. Two main areas can be distinguished in this scenario. The first one is the Amapa Lakes Region, developed over meanders of ancient drainages building a mosaic of low relief forms, with varied shapes, linked throughout communication channels. Two lacustrine belts showing alignments with the main tectonic traces were recognized beginning at the internal limit of the coastal plain, flowing southeast through the Tabaco Creek until reach the Araguari River. In it way it conform the Occidental and Meridional Belts represented by shallow lakes, totally dependent of Tartarugal River discharge and surrounded by enormous areas of peat highly sensitive to fire during the regional low discharge. Light blue clays, peat and a package of tidal deposits with fluidization structures were recognized close to Araguari River, suggesting deposition during high sea level. The second area refers to the coastal zone between the Amapa Grande River and Araguari River, including Maraca Island and the Oriental lacustrine Belt. Westward the island, at least three paleolevels of clays with roots in life position suggests regressive/transgressive events. Extraordinaty paleodrainage network beginnig at the continent and recognized at the insular portion suggests links with the paleochannels found at the continental shelf. The Oriental Belt of lakes is located close to the coastline, at Cabo Norte. It main feature is a mud lump approximately 10 Km ratio, well recognized at the remote sensing. It shows similar evolutionary processes with Araguari River, dating from XIX century, when this river had two mouths defined by the Carpori Island. The reasons of the deactivation are still unknowed, but, this rapid morphological evolution indicates short time colmatation processes that can be linked to tectonic regional processes. On the other hand, the Cabo Norte feature consolidation may impose changes in the sedimentation processes yielding space reduction over the coastal plain accumulation, diminishing of the solid and liquid fluvial discharge and promoting the availability of the local sediment transport over the littoral. The investigation of these processes requires an integrated coastal plain-continental shelf morphological study applying adequate techniques for modification studies and dating ages over short geological time frame, in century scale level.

F-35 Force Development Evaluation and Weapons School Beddown Environmental Impact Statement

DTIC Science & Technology

2011-05-01

deficiencias encontradas después del despliegue del sistema; ♦ explora medios no materiales (por ejemplo, tácticas) para satisfacer requisitos...del adecuado desempeño del avión en combate al proporcionar entrenamiento, información sobre las capacidades operativas y nuevos requisitos. Además

Perk Ablation Ameliorates Myelination in S63del-Charcot–Marie–Tooth 1B Neuropathy

PubMed Central

Musner, Nicolò; Sidoli, Mariapaola; Zambroni, Desireè; Del Carro, Ubaldo; Ungaro, Daniela; D’Antonio, Maurizio; Feltri, Maria L.

2016-01-01

In peripheral nerves, P0 glycoprotein accounts for more than 20% of myelin protein content. P0 is synthesized by Schwann cells, processed in the endoplasmic reticulum (ER) and enters the secretory pathway. However, the mutant P0 with S63 deleted (P0S63del) accumulates in the ER lumen and induces a demyelinating neuropathy in Charcot–Marie–Tooth disease type 1B (CMT1B)–S63del mice. Accumulation of P0S63del in the ER triggers a persistent unfolded protein response. Protein kinase RNA-like endoplasmic reticulum kinase (PERK) is an ER stress sensor that phosphorylates eukaryotic initiation factor 2 alpha (eIF2alpha) in order to attenuate protein synthesis. We have shown that increasing phosphophorylated-eIF2alpha (P-eIF2alpha) is a potent therapeutic strategy, improving myelination and motor function in S63del mice. Here, we explore the converse experiment: Perk haploinsufficiency reduces P-eIF2alpha in S63del nerves as expected, but surprisingly, ameliorates, rather than worsens S63del neuropathy. Motor performance and myelin abnormalities improved in S63del//Perk+/− compared with S63del mice. These data suggest that mechanisms other than protein translation might be involved in CMT1B/S63del neuropathy. In addition, Perk deficiency in other cells may contribute to demyelination in a non–Schwann-cell autonomous manner. PMID:27095827

The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes

PubMed Central

McGraw, K L; Zhang, L M; Rollison, D E; Basiorka, A A; Fulp, W; Rawal, B; Jerez, A; Billingsley, D L; Lin, H-Y; Kurtin, S E; Yoder, S; Zhang, Y; Guinta, K; Mallo, M; Solé, F; Calasanz, M J; Cervera, J; Such, E; González, T; Nevill, T J; Haferlach, T; Smith, A E; Kulasekararaj, A; Mufti, G; Karsan, A; Maciejewski, J P; Sokol, L; Epling-Burnette, P K; Wei, S; List, A F

2015-01-01

Nonsynonymous TP53 exon 4 single-nucleotide polymorphism (SNP), R72P, is linked to cancer and mutagen susceptibility. R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting. Myelodysplastic syndrome (MDS) with chromosome 5q deletion is characterized by erythroid hypoplasia arising from lineage-specific p53 accumulation resulting from ribosomal insufficiency. We hypothesized that apoptotically diminished R72P C-allele may influence predisposition to del(5q) MDS. Bone marrow and blood DNA was sequenced from 705 MDS cases (333 del(5q), 372 non-del(5q)) and 157 controls. Genotype distribution did not significantly differ between del(5q) cases (12.6% CC, 38.1% CG, 49.2% GG), non-del(5q) cases (9.7% CC, 44.6% CG, 45.7% GG) and controls (7.6% CC, 37.6% CG, 54.8% GG) (P=0.13). Allele frequency did not differ between non-del(5q) and del(5q) cases (P=0.91) but trended towards increased C-allele frequency comparing non-del(5q) (P=0.08) and del(5q) (P=0.10) cases with controls. Median lenalidomide response duration increased proportionate to C-allele dosage in del(5q) patients (2.2 (CC), 1.3 (CG) and 0.89 years (GG)). Furthermore, C-allele homozygosity in del(5q) was associated with prolonged overall and progression-free survival and non-terminal interstitial deletions that excluded 5q34, whereas G-allele homozygozity was associated with inferior outcome and terminal deletions involving 5q34 (P=0.05). These findings comprise the largest MDS R72P SNP analysis. PMID:25768405

PubMed

Martínez Carrión, José Miguel; Cámara, Antonio D; Pérez-Castroviejo, Pedro María

2016-12-12

Objetivo: analizar la geografía del estado nutricional en España y su evolución entre mediados del siglo xixy comienzos del siglo xx, etapa previa a la transición nutricional con alta prevalencia de malnutrición.Métodos: se utilizan datos antropométricos agregados (promedios provinciales de estatura) del reclutamiento militar en 1858 y 1913, así como promedios provinciales de estatura y peso procedentes de una revisión realizada entre 119.571 soldados en 1903-1906. Con estos datos se elaboran cartografía y estadísticos descriptivos.Resultados: los parámetros antropométricos de los españoles se situaban entre los valores de complexión más bajos de Europa antes de la transición nutricional. Entre 1858 y 1913, la altura media creció solo 1,43 cm. En ese periodo hubo cambios significativos en la geografía antropométrica marcados por la configuración de una polaridad nutricional a las puertas de la I Guerra Mundial: las provincias del centro y del sur de país exhiben mayor incidencia de la malnutrición crónica que las provincias del arco Noreste, que disfrutan de ventaja relativa en términos nutricionales.Conclusión:las desigualdades territoriales que configuraron una geografía polarizada del estado nutricional en España pueden asociarse en parte a los cambios ambientales del periodo, caracterizados por el inicio de la modernización y la industrialización y, asimismo, por la privación derivada de las crisis agrarias, las enfermedades y el relativo atraso tecnológico. Se destaca la relevancia de la historia antropométrica para el estudio de los niveles de vida en poblaciones del pasado y del proceso de transición nutricional.

Genesis of two most prevalent PROP1 gene variants causing combined pituitary hormone deficiency in 21 populations.

PubMed

Dusatkova, Petra; Pfäffle, Roland; Brown, Milton R; Akulevich, Natallia; Arnhold, Ivo J P; Kalina, Maria A; Kot, Karolina; Krzisnik, Ciril; Lemos, Manuel C; Malikova, Jana; Navardauskaite, Ruta; Obermannova, Barbora; Pribilincova, Zuzana; Sallai, Agnes; Stipancic, Gordana; Verkauskiene, Rasa; Cinek, Ondrej; Blum, Werner F; Parks, John S; Austerlitz, Frederic; Lebl, Jan

2016-03-01

Two variants (c.[301_302delAG];[301_302delAG] and c.[150delA];[150delA]) in the PROP1 gene are the most common genetic causes of recessively inherited combined pituitary hormones deficiency (CPHD). Our objective was to analyze in detail the origin of the two most prevalent variants. In the multicentric study were included 237 patients with CPHD and their 15 relatives carrying c.[301_302delAG];[301_302delAG] or c.[150delA];[150delA] or c.[301_302delAG];[ 150delA]. They originated from 21 different countries worldwide. We genotyped 21 single-nucleotide variant markers flanking the 9.6-Mb region around the PROP1 gene that are not in mutual linkage disequilibrium in the general populations--a finding of a common haplotype would be indicative of ancestral origin of the variant. Haplotypes were reconstructed by Phase and Haploview software, and the variant age was estimated using an allelic association method. We demonstrated the ancestral origin of both variants--c.[301_302delAG] was carried on 0.2 Mb-long haplotype in a majority of European patients arising ~101 generations ago (confidence interval 90.1-116.4). Patients from the Iberian Peninsula displayed a different haplotype, which was estimated to have emerged 23.3 (20.1-29.1) generations ago. Subsequently, the data indicated that both the haplotypes were transmitted to Latin American patients ~13.8 (12.2-17.0) and 16.4 (14.4-20.1) generations ago, respectively. The c.[150delA] variant that was carried on a haplotype spanning about 0.3 Mb was estimated to appear 43.7 (38.4-52.7) generations ago. We present strong evidence that the most frequent variants in the PROP1 gene are not a consequence of variant hot spots as previously assumed, but are founder variants.

Genesis of two most prevalent PROP1 gene variants causing combined pituitary hormone deficiency in 21 populations

PubMed Central

Dusatkova, Petra; Pfäffle, Roland; Brown, Milton R; Akulevich, Natallia; Arnhold, Ivo JP; Kalina, Maria A; Kot, Karolina; Krzisnik, Ciril; Lemos, Manuel C; Malikova, Jana; Navardauskaite, Ruta; Obermannova, Barbora; Pribilincova, Zuzana; Sallai, Agnes; Stipancic, Gordana; Verkauskiene, Rasa; Cinek, Ondrej; Blum, Werner F; Parks, John S; Austerlitz, Frederic; Lebl, Jan

2016-01-01

Two variants (c.[301_302delAG][301_302delAG] and c.[150delA][150delA]) in the PROP1 gene are the most common genetic causes of recessively inherited combined pituitary hormones deficiency (CPHD). Our objective was to analyze in detail the origin of the two most prevalent variants. In the multicentric study were included 237 patients with CPHD and their 15 relatives carrying c.[301_302delAG][301_302delAG] or c.[150delA][150delA] or c.[301_302delAG][ 150delA]. They originated from 21 different countries worldwide. We genotyped 21 single-nucleotide variant markers flanking the 9.6-Mb region around the PROP1 gene that are not in mutual linkage disequilibrium in the general populations – a finding of a common haplotype would be indicative of ancestral origin of the variant. Haplotypes were reconstructed by Phase and Haploview software, and the variant age was estimated using an allelic association method. We demonstrated the ancestral origin of both variants – c.[301_302delAG] was carried on 0.2 Mb-long haplotype in a majority of European patients arising ~101 generations ago (confidence interval 90.1–116.4). Patients from the Iberian Peninsula displayed a different haplotype, which was estimated to have emerged 23.3 (20.1–29.1) generations ago. Subsequently, the data indicated that both the haplotypes were transmitted to Latin American patients ~13.8 (12.2–17.0) and 16.4 (14.4–20.1) generations ago, respectively. The c.[150delA] variant that was carried on a haplotype spanning about 0.3 Mb was estimated to appear 43.7 (38.4–52.7) generations ago. We present strong evidence that the most frequent variants in the PROP1 gene are not a consequence of variant hot spots as previously assumed, but are founder variants. PMID:26059845

La utilizacion de los mapas conceptuales en la ensenanza de biologia y su efecto sobre el dominio del proceso de fotosintesis en los estudiantes universitarios

NASA Astrophysics Data System (ADS)

Gonzalez Rivera, Maria M.

Se investigo el efecto de los mapas conceptuales sobre el dominio del proceso de fotosintesis en estudiantes universitarios. La investigacion utilizo dos estrategias: mapas conceptuales individuales y mapas conceptuales colaborativos, con el fin de investigar si existen diferencias significativas en el dominio del proceso de fotosintesis. El analisis de los datos incluyo aspectos cualitativos y cuantitativos. Se desprende del estudio que el 80% de los estudiantes describen la utilizacion de los mapas conceptuales como una experiencia beneficiosa. El 70% de los estudiantes expreso que los mapas conceptuales son utiles en el aprendizaje del proceso de fotosintesis y el 61% indico que facilitan la comprension de los conceptos. Los hallazgos mas importantes del analisis cuantitativo indican que los estudiantes que utilizaron los mapas conceptuales mejoraron significativamente su desempeno en la posprueba global. Se utilizo la prueba Mann-Whitney para investigar si existian diferencias significativas en la posprueba y preprueba global, el valor de W = 1945.0, para un valor p de 0.00, lo cual establece diferencias significativas. Para determinar si existian diferencias significativas entre la posprueba y preprueba del grupo individual, se realizo la prueba nuevamente. El valor de W correspondio a 490.5, que es significativo, con un valor p de 0.00. Se concluye que existen diferencias significativas entre la ejecucion de la posprueba y preprueba del grupo individual. Los datos proveen suficiente evidencia para sostener que los estudiantes que utilizaron la estrategia de mapas conceptuales individuales mejoraron el dominio del proceso de fotosintesis significativamente. Se realizo nuevamente la prueba para los resultados de posprueba y preprueba del grupo colaborativo. El valor de W correspondio a 446 con un valor p de 0.00. Se concluyo que existen diferencias significativas entre la ejecucion de la posprueba y preprueba del grupo colaborativo. Finalmente, se efectuo una prueba Mann-Whitney comparando la posprueba de ambos grupos. El valor de W fue de a 777, para un valor p de 0.2782. Aunque las puntuaciones de las pospruebas del grupo colaborativo fueron mayores que las puntuaciones de la posprueba del grupo individual, la diferencia no fue estadisticamente significativa.

Association of methylenetetrahydrofolate reductase (MTHFR 677C>T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women.

PubMed

Rah, HyungChul; Jeon, Young Joo; Choi, Youngsok; Shim, Sung Han; Yoon, Tae Ki; Choi, Dong Hee; Cha, Sun Hee; Kim, Nam Keun

2012-11-01

The aim of our study was to investigate whether methylenetetrahydrofolate reductase (MTHFR) gene variant (MTHFR 677C>T) and thymidylate synthase (TS) gene variants (TS enhancer region [TSER] and TS 1494del6) confer a risk for premature ovarian failure (POF). We genotyped 136 POF patients and 236 controls among Korean women for the three single nucleotide polymorphism sites using polymerase chain reaction restriction fragment length polymorphism analysis. Differences in the MTHFR 677C>T, TSER, and TS 1494del6 genotype frequencies between POF patients and controls were compared, and odds ratios (ORs) and 95% CIs were determined as a measure of the strength of the association between genotypes and POF. The MTHFR 677CT and CT + TT variant genotypes were more frequent in POF patients than in controls (OR, 2.249; 95% CI, 1.317-3.843; and OR, 2.132; 95% CI, 1.268-3.585, respectively). The combined genotype frequencies of MTHFR 677CT + TT/TSER 3R3R and 677CT + TT/TS 1494del6 del6/del6 were higher in patients than in controls (OR, 2.300; 95% CI, 1.219-4.337; and OR, 3.314; 95% CI, 1.623-6.767, respectively). The T-3R-del6 and T-2R-del6 (MTHFR 677C>T/TSER/TS 1494del6) haplotypes were more frequent in patients (OR, 1.450; 95% CI, 1.050-2.002; and OR, 2.911; 95% CI, 1.191-7.117, respectively), whereas the C-2R-del6 haplotype was less frequent in patients (OR, 0.372; 95% CI, 0.152-0.912). The T-del6 (MTHFR 677/TS 1494del6) haplotype frequency was higher among patients (OR, 1.653; 95% CI, 1.206-2.266), whereas the C-del6 haplotype frequency was lower among patients (OR, 0.700; 95% CI, 0.516-0.950). We did not find an association between TSER or TS 1494del6 polymorphisms and POF. Our data suggest that the MTHFR 677T allele may increase the risk for POF, which could lead to the development of novel genetic markers for predicting the risk of POF in patients.

Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications.

PubMed

Muranen, Taru A; Greco, Dario; Fagerholm, Rainer; Kilpivaara, Outi; Kämpjärvi, Kati; Aittomäki, Kristiina; Blomqvist, Carl; Heikkilä, Päivi; Borg, Ake; Nevanlinna, Heli

2011-09-20

Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC-mutation carriers. In total, 126 breast tumor tissue specimens including 32 samples from patients carrying CHEK2 1100delC were studied in array-comparative genomic hybridization (aCGH) and gene-expression (GEX) experiments. After dimensionality reduction with CGHregions R package, CHEK2 1100delC-associated regions in the aCGH data were detected by the Wilcoxon rank-sum test. The linear model was fitted to GEX data with R package limma. Genes whose expression levels were associated with CHEK2 1100delC mutation were detected by the bayesian method. We discovered four lost and three gained CHEK2 1100delC-related loci. These include losses of 1p13.3-31.3, 8p21.1-2, 8p23.1-2, and 17p12-13.1 as well as gains of 12q13.11-3, 16p13.3, and 19p13.3. Twenty-eight genes located on these regions showed differential expression between CHEK2 1100delC and other tumors, nominating them as candidates for CHEK2 1100delC-associated tumor-progression drivers. These included CLCA1 on 1p22 as well as CALCOCO1, SBEM, and LRP1 on 12q13. Altogether, 188 genes were differentially expressed between CHEK2 1100delC and other tumors. Of these, 144 had elevated and 44, reduced expression levels.Our results suggest the WNT pathway as a driver of tumorigenesis in breast tumors of CHEK2 1100delC-mutation carriers and a role for the olfactory receptor protein family in cancer progression. Differences in the expression of the 188 CHEK2 1100delC-associated genes divided breast tumor samples from three independent datasets into two groups that differed in their relapse-free survival time. We have shown that copy-number aberrations of certain genomic regions are associated with CHEK2 mutation 1100delC. On these regions, we identified potential drivers of CHEK2 1100delC-associated tumorigenesis, whose role in cancer progression is worth investigating. Furthermore, poorer survival related to the CHEK2 1100delC gene-expression signature highlights pathways that are likely to have a role in the development of metastatic disease in carriers of the CHEK2 1100delC mutation.

Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications

PubMed Central

2011-01-01

Introduction Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC-mutation carriers. Methods In total, 126 breast tumor tissue specimens including 32 samples from patients carrying CHEK2 1100delC were studied in array-comparative genomic hybridization (aCGH) and gene-expression (GEX) experiments. After dimensionality reduction with CGHregions R package, CHEK2 1100delC-associated regions in the aCGH data were detected by the Wilcoxon rank-sum test. The linear model was fitted to GEX data with R package limma. Genes whose expression levels were associated with CHEK2 1100delC mutation were detected by the bayesian method. Results We discovered four lost and three gained CHEK2 1100delC-related loci. These include losses of 1p13.3-31.3, 8p21.1-2, 8p23.1-2, and 17p12-13.1 as well as gains of 12q13.11-3, 16p13.3, and 19p13.3. Twenty-eight genes located on these regions showed differential expression between CHEK2 1100delC and other tumors, nominating them as candidates for CHEK2 1100delC-associated tumor-progression drivers. These included CLCA1 on 1p22 as well as CALCOCO1, SBEM, and LRP1 on 12q13. Altogether, 188 genes were differentially expressed between CHEK2 1100delC and other tumors. Of these, 144 had elevated and 44, reduced expression levels. Our results suggest the WNT pathway as a driver of tumorigenesis in breast tumors of CHEK2 1100delC-mutation carriers and a role for the olfactory receptor protein family in cancer progression. Differences in the expression of the 188 CHEK2 1100delC-associated genes divided breast tumor samples from three independent datasets into two groups that differed in their relapse-free survival time. Conclusions We have shown that copy-number aberrations of certain genomic regions are associated with CHEK2 mutation 1100delC. On these regions, we identified potential drivers of CHEK2 1100delC-associated tumorigenesis, whose role in cancer progression is worth investigating. Furthermore, poorer survival related to the CHEK2 1100delC gene-expression signature highlights pathways that are likely to have a role in the development of metastatic disease in carriers of the CHEK2 1100delC mutation. PMID:21542898

Recent advances on the encoding and selection methods of DNA-encoded chemical library.

PubMed

Shi, Bingbing; Zhou, Yu; Huang, Yiran; Zhang, Jianfu; Li, Xiaoyu

2017-02-01

DNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for ligand discovery in chemical biology research and in drug discovery. Encoding and selection methods are two of the most important technological aspects of DEL that can dictate the performance and utilities of DELs. In this digest, we have summarized recent advances on the encoding and selection strategies of DEL and also discussed the latest developments on DNA-encoded dynamic library, a new frontier in DEL research. Copyright © 2016 Elsevier Ltd. All rights reserved.

A new species of Espeletiopsis (Millerieae, Asteraceae) from Colombia

PubMed Central

Diazgranados, Mauricio; Sánchez, Luis Roberto

2013-01-01

Abstract A new species of Espeletiopsis was found in two small páramos of Norte de Santander, Colombia. The species is named Espeletiopsis diazii honoring the contributions of Santiago Díaz-Piedrahita in recognition of his vast knowledge of the Compositae in Colombia. This is a very distinctive species, markedly different from most of the Espeletiopsis present in Colombia. The new species is closely related to Espeletiopsis caldasii and Espeletiopsis santanderensis, but differs in having (1–)4–6(–7) capitula, with very short peduncles, and capitula arranged in a compact or densely glomerate cyme. With a total distribution area of less than 75 km2, this species is probably critically endangered or imperiled. PMID:24399905

Characterization using XRD of puzzolanic materials from residual sludge from water treatment

NASA Astrophysics Data System (ADS)

Barón, G.; Montaño, A. M.; González, C. P.

2017-12-01

The goal of this work is to do mechanical and chemical characterization of puzzolanic materials using compressive strength measurements and X-Ray Diffraction (XRD). These materials are composed of red clay and aluminous sludge produced by the treatment of potable water at Planta Algodonal, Ocaña, Norte de Santander, Colombia. Ceramic bricks were sintered to 1100°C and ten were characterized in their physically, mechanically and chemically properties. The results showed that the relationships with which the Colombian standards according to NTC 4017 (100KGF/cm2) for non-structural bricks are maintained for those containing 10% (105Kgf/cm2) and 20% (102.9Kgf/cm2) of sludge with respect to clay.

Diverse ages and origins of basement complexes, Luzon, Philippines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geary, E.E.; Harrison, T.M.; Heizler, M.

1988-04-01

Geological field investigations and /sup 40/Ar//sup 39/Ar ages from two basement complexes in southeast Luzon document the first known occurrences of pre-Late Cretaceous age rocks in the eastern Philippines. However, individual components within the two complexes vary in age from Late Jurassic (Caramoan basement complex) to Early Cretaceous and early Miocene (Camarines Norte-Calaguas Islands basement complex). These and other data show that southeast Luzon basement complexes are genetically diverse, and they indicate that the concept of an old, autochthonous basement in the Philippines is open to question. This supports the hypothesis that the Philippine Archipelago is an amalgamation of allochthonousmore » Mesozoic and Cenozoic island-arc, ocean-basin, and continental fragments that were assembled during the Tertiary.« less

Trends in the job market of nurses in the view of managers.

PubMed

Oliveira, Jonas Sâmi Albuquerque de; Pires, Denise Elvira Pires de; Alvarez, Ângela Maria; Sena, Roseni Rosângela de; Medeiros, Soraya Maria de; Andrade, Selma Regina de

2018-01-01

to identify and interpret the main trends of the labor market for nurses in Rio Grande do Norte, based on the opinion of managers of training institutions and employers. Data were collected through interviews with key informants, organized using Atlas.ti software resources and examined under the thematic content review. the study showed six trends in the labor market of nurses: availability of professionals to the market; worsening working conditions with precariousness; indication for insertion in employment; unemployment for nurses; shortage of nurses; and the existence of a cooperative of nursing professionals. the current scenario of growth in the number of registered nurses without the expansion of the job supply has remained, unemployment tends to increase and work conditions will worsen.

CHEK2*1100delC homozygosity in the Netherlands—prevalence and risk of breast and lung cancer

PubMed Central

Huijts, Petra EA; Hollestelle, Antoinette; Balliu, Brunilda; Houwing-Duistermaat, Jeanine J; Meijers, Caro M; Blom, Jannet C; Ozturk, Bahar; Krol-Warmerdam, Elly MM; Wijnen, Juul; Berns, Els MJJ; Martens, John WM; Seynaeve, Caroline; Kiemeney, Lambertus A; van der Heijden, Henricus F; Tollenaar, Rob AEM; Devilee, Peter; van Asperen, Christi J

2014-01-01

The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from North-West Europe. Women heterozygous for 1100delC have an increased breast cancer risk (odds ratio 2.7). To explore the prevalence and clinical consequences of 1100delC homozygosity in the Netherlands, we genotyped a sporadic breast cancer hospital-based cohort, a group of non-BRCA1/2 breast cancer families, and breast tumors from a tumor tissue bank. Three 1100delC homozygous patients were found in the cohort of 1434 sporadic breast cancer patients, suggesting an increased breast cancer risk for 1100delC homozygotes (odds ratio 3.4, 95% confidence interval 0.4–32.6, P=0.3). Another 1100delC homozygote was found in 592 individuals from 108 non-BRCA1/2 breast cancer families, and two more were found after testing 1706 breast tumors and confirming homozygosity on their wild-type DNA. Follow-up data was available for five homozygous patients, and remarkably, three of them had developed contralateral breast cancer. A possible relationship between 1100delC and lung cancer risk was investigated in 457 unrelated lung cancer patients but could not be confirmed. Due to the small number of 1100delC homozygotes identified, the breast cancer risk estimate associated with this genotype had limited accuracy but is probably higher than the risk in heterozygous females. Screening for CHEK2 1100delC could be beneficial in countries with a relatively high allele frequency. PMID:23652375

The -2549 insertion/deletion polymorphism in the promoter region of VEGF is associated with the risk of recurrent spontaneous abortion.

PubMed

Hashemi, Mohammad; Danesh, Hiva; Bizhani, Fatemeh; Mokhtari, Mojgan; Bahari, Gholamreza; Tabasi, Farhad; Taheri, Mohsen

2018-03-01

Recurrent spontaneous abortion (RSA) is a common health problem affecting women of reproductive age. Altered expression of vascular endothelial growth factor ( VEGF ) has been associated with spontaneous abortion. The present case-control study aimed to evaluate the impact of the 18-bp insertion/deletion (ins/del) polymorphism (rs35569394) in the promoter region of the VEGF gene on idiopathic RSA. Genomic DNA from 93 patients with RSA and 93 healthy fertile women of southeastern Iran was isolated using the salting-out method. Genotyping of the rs35569394 variant was performed by a polymerase chain reaction (PCR) method. The findings indicated that the VEGF 18-bp ins/del variant significantly increased the risk of RSA under codominant (ins/ins vs. del/del; OR=2.85, 95% CI=1.31-6.22, P=0.019), dominant (del/ins+ins/ins vs. del/del; OR=2.19, 95% CI=1.20-4.01, P=0.015) and allelic (ins vs. del; OR=1.90, 95% CI=1.25-2.88, P=0.003) inheritance models. In summary, the findings propose a significant association between the VEGF 18-bp ins/del polymorphism and risk of RSA in a sample of the southeast Iranian population. Further studies on larger sample sizes and different ethnicities are required to validate the present findings.

Functional changes in Becker muscular dystrophy: implications for clinical trials in dystrophinopathies.

PubMed

Bello, Luca; Campadello, Paola; Barp, Andrea; Fanin, Marina; Semplicini, Claudio; Sorarù, Gianni; Caumo, Luca; Calore, Chiara; Angelini, Corrado; Pegoraro, Elena

2016-09-01

We performed a 1-year longitudinal study of Six Minute Walk Test (6MWT), North Star Ambulatory Assessment (NSAA), and timed function tests in Becker muscular dystrophy (BMD). Skeletal muscle dystrophin was quantified by immunoblot. We grouped deletions ending on exon 45 ("del 45-x", n = 28) or 51 ("del x-51", n = 10); isolated exon 48 deletion ("del 48", n = 10); and other mutations (n = 21). Only patients in the "del 45-x" or "other" groups became non-ambulatory (n = 5, log-rank p = n.s.) or unable to run (n = 22, p < 0.001). All measures correlated positively with dystrophin quantity and negatively with age, and were significantly more impaired in the "del 45-x" and "other" groups. After one year, NSAA score decreased significantly (-0.9 ± 1.6, p < 0.001); in the "del 45-x" group, both NSAA (-1.3 ± 1.7, p = 0.001) and 6MWT (-12 ± 31 m, p = 0.059) decreased. We conclude that patients with "del x-51" or "del 48" mutations have mild or asymptomatic BMD, while "del 45-x" mutations cause comparatively severe weakness, and functional deterioration in 1 year. Furthermore, exon 51 skipping could be more effective than exon 45 skipping in Duchenne muscular dystrophy.

Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes.

PubMed

Nagel, Jord H A; Peeters, Justine K; Smid, Marcel; Sieuwerts, Anieta M; Wasielewski, Marijke; de Weerd, Vanja; Trapman-Jansen, Anita M A C; van den Ouweland, Ans; Brüggenwirth, Hennie; van I Jcken, Wilfred F J; Klijn, Jan G M; van der Spek, Peter J; Foekens, John A; Martens, John W M; Schutte, Mieke; Meijers-Heijboer, Hanne

2012-04-01

CHEK2 1100delC is a moderate-risk cancer susceptibility allele that confers a high breast cancer risk in a polygenic setting. Gene expression profiling of CHEK2 1100delC breast cancers may reveal clues to the nature of the polygenic CHEK2 model and its genes involved. Here, we report global gene expression profiles of a cohort of 155 familial breast cancers, including 26 CHEK2 1100delC mutant tumors. In line with previous work, all CHEK2 1100delC mutant tumors clustered among the hormone receptor-positive breast cancers. In the hormone receptor-positive subset, a 40-gene CHEK2 signature was subsequently defined that significantly associated with CHEK2 1100delC breast cancers. The identification of a CHEK2 gene signature implies an unexpected biological homogeneity among the CHEK2 1100delC breast cancers. In addition, all 26 CHEK2 1100delC tumors classified as luminal intrinsic subtype breast cancers, with 8 luminal A and 18 luminal B tumors. This biological make-up of CHEK2 1100delC breast cancers suggests that a relatively limited number of additional susceptibility alleles are involved in the polygenic CHEK2 model. Identification of these as-yet-unknown susceptibility alleles should be aided by clues from the 40-gene CHEK2 signature.

Unidades del paisaje de Puerto Rico: la influencia del clima, el substrato y la topografia

Treesearch

William Gould; Michael E. Jimenez; Gary Potts; Maya Quinones; Sebastian Martinuzzi

2008-01-01

El mapa de unidades del paisaje de Puerto Rico representa variaciones climaticas, topograficas y del substrato mediante la integracion de seis zonas climaticas (Ewel y Whitmore, 1973), seis substratos (Bawiec, 2001; USGS, 2005), cinco posiciones topograficas, o topoformas (Martinuzzi et al. 2007), y cuerpos de agua (USGS 2005). Los substratos representan el conjunto...

Extracorporeal membrane oxygenation in children with heart disease and del22q11 syndrome: a review of the Extracorporeal Life Support Organization Registry.

PubMed

Prodhan, P; Gossett, J M; Rycus, P T; Gupta, P

2015-11-01

The study objective was to evaluate outcomes among children with del22q11 (DiGeorge) syndrome supported on ECMO for heart disease. The ELSO registry database was queried to include all children <18 years undergoing heart surgery for either common atrio-ventricular canal, tetralogy of Fallot, truncus arteriosus or transposition of the great vessels and interrupted aortic arch and requiring ECMO, from 1998-2011. The outcomes evaluated included mortality, ECMO duration and length of hospital stay in patients with del22q11 syndrome and with no del22q11 syndrome. Eighty-eight ECMO runs occurred in children with del22q11 syndrome while 2694 ECMO runs occurred in children without del22q11 syndrome. For patients with heart defects receiving ECMO, del22q11 syndrome did not confer a significant mortality risk or an increased risk of infectious complications before or while on ECMO support. Neither the duration of ECMO nor mechanical ventilation prior to ECMO deployment were prolonged in patients with del22q11 syndrome compared to the controls. © The Author(s) 2015.

Thinking processes of Filipino teachers representation of schema of some biology topics: Its effects to the students conceptual understanding

NASA Astrophysics Data System (ADS)

Barquilla, Manuel B.

2018-01-01

This study is a qualitative-quantitative research, where the main concern is to investigate Content knowledge representation of Filipino Teachers in their schema (proposition, linear ordering and imagery) of some biology topics. The five biology topics includes: Photosynthesis, Cellular Respiration, human reproductive system, Mendelian genetics and NonMendelian genetics. The study focuses on the six (6) biology teachers and a total of 222 students in their respective classes. Of the Six (6) teachers, three (3) are under the Science curriculum and three (3) under regular curriculum in both public and private schools in Iligan city and Lanao del Norte, Philippines. The study utilizes interpretative case-study method, bracketing method, and concept analysis for qualitative part. For quantitative, it uses a nonparametric statistical tool, Kendall's Tau to determine congruence of students and teachers' concept maps and paired t-test for testing the significant differences of pre-and post-instruction concept maps to determine the effects of students' conceptual understanding before and after the teacher's representation of their schema that requires the teachers' thinking processes. The data were cross-validated with two or more techniques used in the study. The data collection entailed seven (7) months immersion: one (1) month for preliminary phase for the researcher to gain teachers' and students' confidence and the succeeding six (6) months for main observation and data collection. Results indicate that the teacher utilize six methods to construct meaning of concepts, three methods of representing classification, four methods to represent relationships, seven methods to represent transformation and three methods to represent causation in planning and implementing the lessons. They often modify definitions in the textbook and express these in lingua franca to be better understood by the students. Furthermore, the teachers' analogs given to student are sometimes far from the things, objects, events or processes being compared to. This suggests that teachers sometimes provide the condition for students' developing alternative conception through analogy/metaphors that they give. Also, the results suggest that there is significant differences between the pre and post instruction mean scores of concept maps before and after the teacher representation of their schema. Moreover, most of the topic (photosynthesis, human reproductive system, Mendelian and non-Mendelian genetics) studied have moderately or substantial to high agreement between the two groups. Hence, suggest that the teachers' representation highly influence student conceptual.

Percepcion de los profesores universitarios acerca del concepto cultura cientifica y de sus implicaciones en el nuevo bachillerato del Recinto de Rio Piedras de la Universidad de Puerto Rico

NASA Astrophysics Data System (ADS)

Ramos Pastrana, Nilsa

El Senado Academico del Recinto de Rio Piedras de la Universidad de Puerto Rico aprobo en el ano academico 2005-2006 la Certificacion 46, que contiene los lineamientos de un nuevo bachillerato. Este nuevo bachillerato introdujo cambios significativos en el curriculo tradicional. Entre ellos se encuentra la reduccion del componente de educacion general y el de Ciencias Biologicas en particular. La reduccion de creditos en el componente de Ciencias Biologicas ha obligado a reevaluar el concepto de cultura cientifica que desarrollan esos cursos. El proposito del estudio consistio en auscultar las percepciones de los profesores de las Facultades de Administracion de Empresas, Humanidades, Ciencias Sociales, Ciencias Naturales, Educacion y Estudios Generales del Recinto de Rio Piedras de la Universidad de Puerto Rico en torno al concepto de cultura cientifica, los contenidos disciplinares del curso de Ciencias Biologicas y la reduccion de creditos en el nuevo bachillerato. Las preguntas que guiaron la investigacion fueron: ¿cuales son las percepciones que tienen los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Estudios Generales, Ciencias Naturales, Humanidades y Educacion, en torno al concepto de cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿cuales son las percepciones que tienen los profesores de Ciencias Biologicas en torno al concepto cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿existen diferencias significativas por facultad, genero, experiencia, rango y nombramiento en las percepciones que tienen los profesores del Recinto de Rio Piedras de la Universidad de Puerto Rico sobre los elementos que caracterizan la cultura cientifica y los contenidos biologicos que deben tener los egresados del Recinto? ¿que implicaciones curriculares tienen estos testimonios en el desarrollo del concepto de cultura cientifica en el nuevo bachillerato? Para realizar la investigacion se utilizo una metodologia cuantitativa y la herramienta para lograrlo fue una encuesta. La encuesta se analizo estadisticamente mediante analisis de frecuencias y por cientos, prueba ANOVA, prueba t, pruebas Post Hoc de Tukey y de Levene. Tambien se realizo nuevamente una prueba de confiabilidad mediante el alfa de Cronbach. Los resultados reflejaron que los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Ciencias Naturales, Educacion, Humanidades, Estudios Generales y el Departamento de Ciencias Biologicas tienen una percepcion muy positiva del concepto de cultura cientifica, los contenidos curriculares de Ciencias Biologicas y del nuevo bachillerato.

Interstitial 13q14 deletions detected in the karyotype and translocations with concomitant deletion at 13q14 in chronic lymphocytic leukemia: different genetic mechanisms but equivalent poorer clinical outcome.

PubMed

Puiggros, Anna; Venturas, Marta; Salido, Marta; Blanco, Gonzalo; Fernandez-Rodriguez, Concepción; Collado, Rosa; Valiente, Alberto; Ruiz-Xivillé, Neus; Carrió, Ana; Ortuño, Francisco José; Luño, Elisa; Calasanz, María José; Ardanaz, María Teresa; Piñán, María Ángeles; Talavera, Elisabet; González, María Teresa; Ortega, Margarita; Marugán, Isabel; Ferrer, Ana; Gimeno, Eva; Bellosillo, Beatriz; Delgado, Julio; Hernández, José Ángel; Hernández-Rivas, Jesús María; Espinet, Blanca

2014-09-01

Deletion of 13q14 as the sole abnormality is a good prognostic marker in chronic lymphocytic leukemia (CLL). Nonetheless, the prognostic value of reciprocal 13q14 translocations [t(13q)] with related 13q losses has not been fully elucidated. We described clinical and biological characteristics of 25 CLL patients with t(13q), and compared with 62 patients carrying interstitial del(13q) by conventional G-banding cytogenetics (CGC) [i-del(13q)] and 295 patients with del(13q) only detected by fluorescence in situ hybridization (FISH) [F-del(13q)]. Besides from the CLL FISH panel (D13S319, CEP12, ATM, TP53), we studied RB1 deletions in all t(13q) cases and a representative group of i-del(13q) and F-del(13q). We analyzed NOTCH1, SF3B1, and MYD88 mutations in t(13q) cases by Sanger sequencing. In all, 25 distinct t(13q) were described. All these cases showed D13S319 deletion while 32% also lost RB1. The median percentage of 13q-deleted nuclei did not differ from i-del(13q) patients (73% vs. 64%), but both were significantly higher than F-del(13q) (52%, P < 0.001). Moreover, t(13q) patients showed an increased incidence of biallelic del(13q) (52% vs. 11.3% and 14.9%, P < 0.001) and higher rates of concomitant 17p deletion (37.5% vs. 8.6% and 7.2%, P < 0.001). RB1 involvement was significantly higher in the i-del(13q) group (79%, P < 0.001). Two t(13q) patients (11.8%) carried NOTCH1 mutations. Time to first treatment in t(13q) and i-del(13q) was shorter than F-del(13q) (67, 44, and 137 months, P = 0.029), and preserved significance in the multivariate analysis. In conclusion, t(13q) and del(13q) patients detected by CGC constitute a subgroup within the 13q-deleted CLL patients associated with a worse clinical outcome. © 2014 Wiley Periodicals, Inc.

El Alcalde José Carlos Aponte Dalmau del Municipio de Carolina es nombrado a formar parte del Comité Asesor de Gobiernos Locales de la EPA a nivel de todos los Estados Unidos

EPA Pesticide Factsheets

Comunicado de prensa de la EPA: El Alcalde José Carlos Aponte Dalmau del Municipio de Carolina es nombrado a formar parte del Comité Asesor de Gobiernos Locales de la EPA a nivel de todos los Estados Unidos

Excess breast cancer risk in first degree relatives of CHEK2∗1100delC positive familial breast cancer cases.

PubMed

Adank, Muriel A; Verhoef, Senno; Oldenburg, Rogier A; Schmidt, Marjanka K; Hooning, Maartje J; Martens, John W M; Broeks, Annegien; Rookus, Matti; Waisfisz, Quinten; Witte, Birgit I; Jonker, Marianne A; Meijers-Heijboer, Hanne

2013-05-01

The CHEK2∗1100delC mutation confers a relative risk of two for breast cancer (BC) in the general population. This study aims to explore the excess cancer risk due to the CHEK2∗1100delC mutation within a familial non-BRCA1/2 breast cancer setting. Cancer incidences were compared between first degree relatives of 107 familial breast cancer patients positive for the CHEK2∗1100delC mutation (CHEK2 positive families) and first degree relatives of 314 familial breast cancer patients without the CHEK2∗1100delC mutation (CHEK2 negative families). All families were derived from the same pool of familial non-BRCA1/2 breast cancer families (n=2554). Medical information of 2188 first degree relatives of these families was analysed for cancer risk. CHEK2∗1100delC status of relatives was unknown. Increased breast cancer risk (hazard ratio (HR) 2.0 (95% confidence interval (CI): 1.4-2.7), p<0.001) was observed in sisters of CHEK2∗1100delC positive index cases compared to sisters of CHEK2∗1100delC negative index cases. HR was 1.6 (95% CI: 1.0-2.4) for mothers of CHEK2 positive versus negative index cases (p=0.041). For second primary breast cancers HR was increased in CHEK2∗1100delC positive index cases (HR 2.1, 95% CI: 1.3-3.3, p=0.003) and their sisters (HR 2.6, 95% CI: 1.1-6.1, p=0.025). There is an excess breast cancer risk in first degree relatives of CHEK2∗1100delC positive non-BRCA1/2 familial breast cancer patients compared to non-CHEK2∗1100delC familial breast cancer relatives. Genotyping for the CHEK2∗1100delC mutation in a familial breast cancer setting contributes to optimal clinical surveillance in countries in which this mutation is prevalent. Carriers and female relatives are eligible for stringent breast surveillance programs. Copyright © 2013 Elsevier Ltd. All rights reserved.

Two Small Molecules Restore Stability to a Subpopulation of the Cystic Fibrosis Transmembrane Conductance Regulator with the Predominant Disease-causing Mutation.

PubMed

Meng, Xin; Wang, Yiting; Wang, Xiaomeng; Wrennall, Joe A; Rimington, Tracy L; Li, Hongyu; Cai, Zhiwei; Ford, Robert C; Sheppard, David N

2017-03-03

Cystic fibrosis (CF) is caused by mutations that disrupt the plasma membrane expression, stability, and function of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl - channel. Two small molecules, the CFTR corrector lumacaftor and the potentiator ivacaftor, are now used clinically to treat CF, although some studies suggest that they have counteracting effects on CFTR stability. Here, we investigated the impact of these compounds on the instability of F508del-CFTR, the most common CF mutation. To study individual CFTR Cl - channels, we performed single-channel recording, whereas to assess entire CFTR populations, we used purified CFTR proteins and macroscopic CFTR Cl - currents. At 37 °C, low temperature-rescued F508del-CFTR more rapidly lost function in cell-free membrane patches and showed altered channel gating and current flow through open channels. Compared with purified wild-type CFTR, the full-length F508del-CFTR was about 10 °C less thermostable. Lumacaftor partially stabilized purified full-length F508del-CFTR and slightly delayed deactivation of individual F508del-CFTR Cl - channels. By contrast, ivacaftor further destabilized full-length F508del-CFTR and accelerated channel deactivation. Chronic (prolonged) co-incubation of F508del-CFTR-expressing cells with lumacaftor and ivacaftor deactivated macroscopic F508del-CFTR Cl - currents. However, at the single-channel level, chronic co-incubation greatly increased F508del-CFTR channel activity and temporal stability in most, but not all, cell-free membrane patches. We conclude that chronic lumacaftor and ivacaftor co-treatment restores stability in a small subpopulation of F508del-CFTR Cl - channels but that the majority remain destabilized. A fuller understanding of these effects and the characterization of the small F508del-CFTR subpopulation might be crucial for CF therapy development. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutations

PubMed Central

Carranza, Hernán; Vargas, Carlos; Otero, Jorge; Corrales-Rodriguez, Luis; Martín, Claudio; Reguart, Noemí; Archila, Pilar; Rodríguez, July; Cuello, Mauricio; Ortíz, Carlos; Franco, Sandra; Rolfo, Christian; Rosell, Rafael

2016-01-01

Background Germline alterations in the proapoptotic protein Bcl-2-like 11 (BIM) can have a crucial role in diverse tumors. To determine the clinical utility of detecting BIM deletion polymorphisms (par4226 bp/ par363 bp) in EGFR positive non-small-cell lung cancer (NSCLC) we examined the outcomes of patients with and without BIM alterations. Results BIM deletion was present in 14 patients (15.7%). There were no significant differences between patients with and without BIM-del in clinical characteristics or EGFR mutation type; however, those with BIM-del had a worse overall response rate (ORR) to erlotinib (42.9% vs. 73.3% in patients without BIM-del; p=0.024) as well as a significantly shorter progression-free survival (PFS) (10.8 BIM-del+ vs. 21.7 months for patients without BIM-del; p=0.029) and overall survival (OS) (15.5 BIM-del+ vs. 34.0 months for patients without BIM-del; p=0.035). Multivariate Cox regression analysis showed that BIM-del+ was an independent indicator of shorter PFS (HR 3.0; 95%CI 1.2-7.6; p=0.01) and OS (HR 3.4; 95%CI 1.4-8.3; p=0.006). Methods We studied 89 NSCLC Hispanic patients with EGFR mutation who were treated with erlotinib between January 2009 and November 2014. BIM deletion polymorphisms (BIM-del) was analyzed by PCR in formalin-fixed paraffin-embedded (FFPE) tissues of tumor biopsies. We retrospectively analyzed clinical characteristics, response rate, toxicity, and outcomes among patients with and without BIM-del. Conclusions The incidence of BIM-del found in Hispanic patients is similar to that previously described in Asia. This alteration is associated with a poor clinical response to erlotinib and represents an independent prognostic factor for patients who had NSCLC with an EGFR mutation. PMID:27926478

BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutations.

PubMed

Cardona, Andrés F; Rojas, Leonardo; Wills, Beatriz; Arrieta, Oscar; Carranza, Hernán; Vargas, Carlos; Otero, Jorge; Corrales-Rodriguez, Luis; Martín, Claudio; Reguart, Noemí; Archila, Pilar; Rodríguez, July; Cuello, Mauricio; Ortíz, Carlos; Franco, Sandra; Rolfo, Christian; Rosell, Rafael; on behalf of the CLICaP

2016-09-19

Germline alterations in the proapoptotic protein Bcl-2-like 11 (BIM) can have a crucial role in diverse tumors. To determine the clinical utility of detecting BIM deletion polymorphisms (par4226 bp/ par363 bp) in EGFR positive non-small-cell lung cancer (NSCLC) we examined the outcomes of patients with and without BIM alterations. BIM deletion was present in 14 patients (15.7%). There were no significant differences between patients with and without BIM-del in clinical characteristics or EGFR mutation type; however, those with BIM-del had a worse overall response rate (ORR) to erlotinib (42.9% vs. 73.3% in patients without BIM-del; p=0.024) as well as a significantly shorter progression-free survival (PFS) (10.8 BIM-del+ vs. 21.7 months for patients without BIM-del; p=0.029) and overall survival (OS) (15.5 BIM-del+ vs. 34.0 months for patients without BIM-del; p=0.035). Multivariate Cox regression analysis showed that BIM-del+ was an independent indicator of shorter PFS (HR 3.0; 95%CI 1.2-7.6; p=0.01) and OS (HR 3.4; 95%CI 1.4-8.3; p=0.006). We studied 89 NSCLC Hispanic patients with EGFR mutation who were treated with erlotinib between January 2009 and November 2014. BIM deletion polymorphisms (BIM-del) was analyzed by PCR in formalin-fixed paraffin-embedded (FFPE) tissues of tumor biopsies. We retrospectively analyzed clinical characteristics, response rate, toxicity, and outcomes among patients with and without BIM-del. The incidence of BIM-del found in Hispanic patients is similar to that previously described in Asia. This alteration is associated with a poor clinical response to erlotinib and represents an independent prognostic factor for patients who had NSCLC with an EGFR mutation.

El uso de la neuromodulación para el tratamiento del temblor

PubMed Central

Bendersky, Damián; Ajler, Pablo; Yampolsky, Claudio

2014-01-01

Introducción: El temblor puede ser un desorden incapacitante y el tratamiento de primera línea para estos pacientes es farmacológico. Sin embargo, este tratamiento puede llevar a una reducción satisfactoria del temblor en sólo el 50% de los pacientes con temblor esencial. La talamotomía era el tratamiento de elección para el temblor refractario al tratamiento médico hasta que comenzó a utilizarse la estimulación cerebral profunda (ECP) del núcleo ventral intermedio (Vim) del tálamo. En la actualidad, raramente se realiza la talamotomía. Métodos: Este artículo es una revisión no sistemática de las indicaciones, resultados, parámetros de programación y técnica quirúrgica de la ECP del Vim para el tratamiento del temblor. Resultados: Aunque los resultados clínicos son similares usando la talamotomía o la ECP del Vim, la primera causa más efectos adversos que la última. Además, la ECP puede ser usada bilateralmente, mientras que la talamotomía tiene un alto riesgo de causar disartria cuando se realiza de ambos lados. La ECP del Vim logró una adecuada mejoría del temblor en varias series de pacientes con temblor causado por temblor esencial, enfermedad de Parkinson o esclerosis múltiple. Además del Vim, hay otros blancos que están siendo usados por varios autores, tales como la zona incerta y las radiaciones prelemniscales. Conclusión: La ECP del Vim es un tratamiento útil para el temblor incapacitante refractario al tratamiento médico. Es esencial realizar una precisa selección de pacientes, así como utilizar una técnica quirúrgica correcta. Aún se desconoce el mejor blanco estereotáctico para el temblor, aunque el Vim es el más usado. PMID:25165613

Expression of exon-8-skipped kindlin-1 does not compensate for defects of Kindler syndrome.

PubMed

Natsuga, Ken; Nishie, Wataru; Shinkuma, Satoru; Nakamura, Hideki; Matsushima, Yoichiro; Tatsuta, Aya; Komine, Mayumi; Shimizu, Hiroshi

2011-01-01

Kindler syndrome (KS) is a rare, inherited skin disease characterized by blister formation and generalized poikiloderma. Mutations in KIND1, which encodes kindlin-1, are responsible for KS. c.1089del/1089+1del is a recurrent splice-site deletion mutation in KS patients. To elucidate the effects of c.1089del/1089+1del at the mRNA and protein level. Two KS patients with c.1089del/1089+1del were included in this study. Immunofluorescence analysis of KS skin samples using antibodies against the dermo-epidermal junction proteins was performed. Exon-trapping experiments were performed to isolate the mRNA sequences transcribed from genomic DNA harbouring c.1089del/1089+1del. β1 integrin activation in HeLa cells transfected with truncated KIND1 cDNA was analyzed. Immunofluorescence study showed positive expression of kindlin-1 in KS skin with c.1089del/1089+1del mutation. We identified the exon-8-skipped in-frame transcript as the main product among multiple splicing variants derived from that mutation. HeLa cells transfected with KIND1 cDNA without exon 8 showed impaired β1 integrin activation. Exon-8-coding amino acids are located in the FERM F2 domain, which is conserved among species, and the unstructured region between F2 and the pleckstrin homology domain. This study suggests that exon-8-skipped truncated kindlin-1 is functionally defective and does not compensate for the defects of KS, even though kindlin-1 expression in skin is positive. Copyright © 2010 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

Max Brödel: his art, legacy, and contributions to neurosurgery through medical illustration.

PubMed

Patel, Smruti K; Couldwell, William T; Liu, James K

2011-07-01

Max Brödel is considered the father of modern medical illustration. This report reviews his contributions to neurosurgery as a medical illustrator. Max Brödel, a young artist from Leipzig, Germany, was hired at Johns Hopkins Hospital in 1894, where he illustrated an operative textbook of gynecology for Howard A. Kelly. Although Brödel did not have any formal medical training, he quickly acquired knowledge of anatomy, pathology, physiology, and surgery. Brödel's extraordinary illustrations were characterized by an aerial perspective that conveyed the surgeon's operative viewpoint and precise surgical anatomy. He masterfully incorporated tissue realism with cross-sectional anatomy to accentuate concepts while maintaining topographical accuracy. Brödel's reputation spread quickly and resulted in collaborations with prominent surgeons, such as Cushing, Halsted, and Dandy. Cushing, who also possessed artistic talent, became a pupil of Brödel and remained a very close friend. In 1911, Brödel was appointed the director of the Department of Art as Applied to Medicine at Johns Hopkins, the first academic department of its kind in the world. For the next several decades, he trained generations of renowned medical illustrators. Just as Osler, Halsted, and Cushing passed their skills and knowledge to future leaders of medicine and surgery, Brödel did the same for the field of medical illustration. The advancement of neurosurgical education has been greatly facilitated by Max Brödel's artistic contributions. His unique ability to synthesize art and medicine resulted in timeless illustrations that remain indispensable to surgeons. The art produced by his legacy of illustrators continues to flourish in neurosurgical literature today.

Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation.

PubMed

Schulze, Jenny Jakobsson; Lundmark, Jonas; Garle, Mats; Skilving, Ilona; Ekström, Lena; Rane, Anders

2008-07-01

Testosterone abuse is conventionally assessed by the urinary testosterone/epitestosterone (T/E) ratio, levels above 4.0 being considered suspicious. The large variation in testosterone glucuronide (TG) excretion and its strong association with a deletion polymorphism in the uridine diphospho-glucuronosyl transferase (UGT) 2B17 gene challenge the accuracy of the T/E ratio test. Our objective was to investigate whether genotype-based cutoff values will improve the sensitivity and specificity of the test. This was an open three-armed comparative study. A total of 55 healthy male volunteers with either two, one, or no allele [insertion/insertion, insertion/deletion, or deletion/deletion (del/del)] of the UGT2B17 gene was included in the study. A single im dose of 500 mg testosterone enanthate was administered. Urinary excretion of TG after dose and the T/E ratio during 15 d were calculated. The degree and rate of increase in the TG excretion rate were highly dependent on the UGT2B17 genotype with a 20-fold higher average maximum increase in the insertion/insertion group compared with the del/del group. Of the del/del subjects, 40% never reached the T/E ratio of 4.0 on any of the 15 d after the dose. When differentiated cutoff levels for the del/del (1.0) and the other genotypes (6.0) were applied, the sensitivity increased substantially for the del/del group, and false positives in the other genotypes were eliminated. Consideration of the genetic variation in disposition of androgens will improve the sensitivity and specificity of the testosterone doping test. This is of interest not only for combating androgen doping in sports, but also for detecting and preventing androgen abuse in society.

Lack of effect of the alpha2C-adrenoceptor Del322-325 polymorphism on inhibition of cyclic AMP production in HEK293 cells.

PubMed

Montgomery, M D; Bylund, D B

2010-02-01

The alpha(2C)-adrenoceptor has multiple functions, including inhibiting release of noradrenaline from presynaptic nerve terminals. A human alpha(2C) polymorphism, Del322-325, a potential risk factor for heart failure, has been reported to exhibit reduced signalling in CHO cells. To further understand the role of the Del322-325 polymorphism on receptor signalling, we attempted to replicate and further study the reduced signalling in HEK293 cells. Human alpha(2C) wild-type (WT) and Del322-325 adrenoceptors were stably transfected into HEK293 cells. Radioligand binding was performed to determine affinities for both receptors. In intact cells, inhibition of forskolin-stimulated cyclic AMP production by WT and Del322-325 clones with a range of receptor densities (200-2320 fmol.mg(-1) protein) was measured following agonist treatment. Noradrenaline, brimonidine and clonidine exhibited similar binding affinities for WT and Del322-325. Brimonidine and clonidine also had similar efficacies and potencies for both receptors for the inhibition of cyclic AMP production at all receptor densities tested. A linear regression analysis comparing efficacy and potency with receptor expression levels showed no differences in slopes between WT and Del322-325. The alpha(2C) WT and Del322-325 adrenoceptors exhibited similar binding properties. Additionally, inhibition of cyclic AMP production by Del322-325 was similar to that of WT over a range of receptor densities. Therefore, in intact HEK293 cells, the alpha(2C)-Del322-325 polymorphism does not exhibit reduced signalling to adenylyl cyclase and may not represent a clinically important phenotype.

[Not Available].

PubMed

Cruz-Sáez, María Soledad; Pascual Jimeno, Aitziber; Wlodarczyk, Anna; Polo-López, Rocío; Echeburúa Odriozola, Enrique

2016-07-19

Introducción: los problemas relacionados con el peso constituyen un problema importante de salud pública debido a su alta prevalencia y a las adversas consecuencias que tienen para la salud.Objetivo: el objetivo principal de este estudio fue analizar si la depresión y la ansiedad tienen un papel mediador en la relación entre la insatisfacción corporal y las conductas de control del peso en chicas adolescentes con sobrepeso.Material y métodos: en el estudio participaron 140 mujeres de 16 a 20 años con sobrepeso. Las participantes tuvieron que cumplimentar la escala de insatisfacción corporal del EDI-2, las escalas de ansiedad y depresión del GHQ-28 y una adaptación de las escalas del EAT survey para evaluar las conductas de control del peso. Para los análisis estadísticos se utilizaron métodos de diferencias de medias, correlaciones y de mediación secuencial.Resultados: las adolescentes con sobrepeso y alta insatisfacción corporal presentaban más sintomatología ansiosa y depresiva, así como mayor cantidad de conductas de control del peso. Los resultados del análisis de mediación secuencial evidencian que el efecto de la insatisfacción corporal en las conductas de control del peso está parcialmente mediado por las variables depresión y ansiedad. Mientras que la sintomatología ansiosa presenta efectos directos e indirectos sobre las conductas de control de peso, la sintomatología depresiva solamente presenta un efecto indirecto.Conclusiones:los resultados del estudio destacan el rol mediador de la sintomatología depresiva y, especialmente, de la ansiedad en el desarrollo de conductas no saludables de control del peso.

Mirror Coronograph for Argentina (MICA). Primera Luz

NASA Astrophysics Data System (ADS)

Stenborg, G.; Epple, A.; Schwenn, R.; Francile, C.; Rovira, M.

En Julio de 1997 se terminó con la primera parte de la instalación del ``Coronógrafo de Espejo para la Argentina'' en la estación de altura Carlos U. Cesco (El Leoncito), gracias al esfuerzo de la gente del Max Planck Institut für Aeronomie (Alemania), del OAFA y del IAFE. Dicho coronógrafo forma parte de un programa de ciencia bilateral entre Alemania y Argentina. El propósito del mismo, en conjunción con otros telescopios solares y terrestres, es contribuir a un mejor entendimiento de cuestiones fundamentales de la física solar. Para ello, ya está observando la corona de emisión en el verde (Fe XIV), rojo (Fe X) y Hα entre 1.05 y 2 radios solares aproximadamente. El diseño del instrumento, el cual fuera ya presentado en esta misma reunión en La Plata en 1996, es esencialmente similar al del telescopio LASCO-C1 a bordo del Solar Heliospheric Observatory (SOHO). La adquisición de datos se realiza con un CCD de 1280x1024 pixels, codificando en 12 bits, pudiendo ser el mismo operado en forma remota. En esta reunión presentaremos algunas de las observaciones realizadas durante la puesta a punto del instrumento en el período julio-setiembre de 1997. Asimismo expondremos cómo y por qué sus resultados complementarán a los de su par en el espacio.

Efecto del Programa de Entrenamiento “Manejo del Dolor” en la Documentación de Enfermería en el Expediente Electrónico

PubMed Central

Monsiváis, María Guadalupe Moreno; Guzmán, Ma. Guadalupe Interial; Flores, Paz Francisco Sauceda; Arreola, Leticia Vázquez

2012-01-01

Resumen En el presente trabajo se muestra la importancia de entrenar al personal de enfermería para mejorar la documentación en el expediente electrónico. Se eligió el manejo del dolor por ser un área prioritaria; una alta proporción de pacientes en período post operatorio cursa con dolor, por lo tanto, la documentación debe ser útil para la toma de decisiones clínicas. Se implementó un programa de entrenamiento denominado “Manejo del Dolor” dirigido al personal de enfermería. Se utilizó la tecnología de la información como herramienta para fortalecer el conocimiento con base en la revisión sistemática de la literatura; el personal de enfermería participante seleccionó la mejor evidencia; posteriormente se trabajó en la transferencia de este conocimiento a la práctica a través del diseño de un protocolo para el manejo del dolor. Se concluye que el conocimiento del manejo del dolor es fundamental para que enfermería documente con mayor precisión sus intervenciones. PMID:24199106

[Not Available].

PubMed

Fernández Castillo, Rafael; Cañadas de la Fuente, Gustavo R; Cañadas de la Fuente, Guillermo A; De la Fuente Solana, Emilia Inmaculada; Esteban de la Rosa, Rafael José; Bravo Soto, Juan

2016-07-19

Introducción: la obesidad y el sobrepeso presentan efectos adversos sobre la salud, lo que contribuye a la aparición de enfermedades metabólicas y cardiovasculares que ponen en peligro la integridad del injerto.Objetivo: investigar la influencia del IMC pretrasplante renal sobre el funcionamiento del injerto renal al año de trasplante mediante el estudio de cuatro métodos distintos de medir la filtración glomerular.Material y métodos: en este trabajo se ha seguido a 1.336 pacientes de ambos sexos trasplantados renales; se les realizaron mediciones pretrasplante y postrasplante de parámetros bioquímicos, mediciones antropométricas y función renal mediante medidas de filtrado glomerular.Resultados: a mayor índice de masa corporal pretrasplante se produce una disminución del filtrado glomerular medido por cuatro métodos distintos, así como mayor porcentaje de rechazos.Conclusiones: un IMC elevado pretrasplante contribuye a la disfunción del injerto, a una disminución del filtrado glomerular y a complicaciones del injerto en el primer año postrasplante.

Espectroscopia del Cometa Halley

NASA Astrophysics Data System (ADS)

Naranjo, O.; Fuenmayor, F.; Ferrin, L.; Bulka, P.; Mendoza, C.

1987-05-01

Se reportan observaciones espectroscópicas del cometa Halley. Los espectros fueron tomados usando el espectrógrafo del telescopio reflector de 1 metro del Observatorio Nacional de Venezuela. Se utilizó óptica azul, con una red de difracción de 600 lineas/min, obteniéndose una dispersión de 74.2 A/mm y una resolución de 2.5 A, en el rango espectral de 3500 a 6500 A. Seis placas fueron tomadas con emulsión IIa-O y dos con IIa-D. Los tiempos de exposición fueron entre 10 y 150 minutos. El cometa se encontraba entre 0.70 y 1.04 UA del Sol, y entre 1.28 y 0.73 UA de la Tierra. Las emisiones más prominentes en el espectro, son las del CN, C2, y C3. Otras emisiones detectadas corresponden a CH, NH2 y Na. Los espectros muestran un fuerte continuo, indicando un contenido significativo de polvo. Se detectó mayor intensidad del contínuo, en la dirección anti solar, lo cual es evidencia de la cola de polvo.

Impacto del Seguro Popular en el gasto catastrófico y de bolsillo en el México rural y urbano, 2005–2008

PubMed Central

Sosa-Rubí, Sandra G; Salinas-Rodríguez, Aarón; Galárraga, Omar

2016-01-01

Objetivo Estimar el efecto del Seguro Popular (SP) sobre la incidencia del gasto catastrófico en salud (GCS) y sobre el gasto de bolsillo en salud (GBS) en el mediano plazo. Material y métodos Con base en la Encuesta de Evaluación del Seguro Popular (2005–2008), se analizaron los resultados del efecto del SP en la cohorte rural para dos años de seguimiento (2006 y 2008) y en la cohorte urbana para un año (2008). Resultados A nivel conglomerado no se detectaron efectos del SP. A nivel hogar se encontró que el SP tiene un efecto protector en el GCS y en el GBS en consulta externa y hospitalización en zonas rurales; y efectos significativos en la reducción de GBS en consulta externa en zonas urbanas. Conclusiones El SP se muestra como un programa efectivo para proteger a los hogares contra gastos de bolsillo por motivos de salud en el mediano plazo. PMID:22282205

[Trattamento del disturbo da uso di alcol da un punto di vista psicologico].

PubMed

Coriale, Giovanna; Fiorentino, Daniela; De Rosa, Francesca; Solombrino, Simona; Scalese, Bruna; Ciccarelli, Rosaria; Attilia, Fabio; Vitali, Mario; Musetti, Alessia; Fiore, Marco; Ceccanti, Mauro

2018-01-01

RIASSUNTO. L'elaborazione del piano di trattamento rappresenta un momento molto delicato e complesso del processo terapeutico del disturbo da abuso di alcol (DUA). È la fase in cui le informazioni raccolte da un'équipe di professionisti (medici, psicologi e assistenti sociali) (modello bio-psico-sociale del DUA) vengono messe insieme per decidere il percorso terapeutico più adatto. Per quanto riguarda la parte psicologica, è di notevole importanza scegliere un trattamento clinico in grado di ridurre al minimo la mancata adesione al trattamento e, per i soggetti che rimangono in trattamento, di garantirne l'efficacia. Se da una parte, le tecniche psicoanalitiche e comportamentali hanno fornito le basi della terapia psicologica dell'alcolismo, dall'altra, gli approcci basati sull'evidenza scientifica sono stati elaborati a partire dai principi del colloquio motivazionale e della terapia cognitivo-comportamentale. In questo articolo viene fornita una panoramica dei trattamenti che sono risultati più efficaci nel trattare il DUA e delle modalità temporali più adeguate per monitorare l'efficacia del trattamento.

CHEK2 1100delC and male breast cancer in the Netherlands.

PubMed

Wasielewski, Marijke; den Bakker, Michael A; van den Ouweland, Ans; Meijer-van Gelder, Marion E; Portengen, Henk; Klijn, Jan G M; Meijers-Heijboer, Hanne; Foekens, John A; Schutte, Mieke

2009-07-01

Mutations in the breast cancer susceptibility genes BRCA1, BRCA2, and CHEK2 are known risk factors for female breast cancer. Mutations in BRCA1 and BRCA2 also are associated with male breast cancer (MBC). Similarly, it had been suggested in the original CHEK2 identification report that the CHEK2 1100delC mutation confers an increased risk for MBC. Here, we have evaluated the risk of CHEK2 1100delC for MBC by genotyping CHEK2 1100delC in 23 familial and 71 unselected Dutch MBC cases. None of the 23 familial MBC cases carried the CHEK2 1100delC mutation. In contrast, CHEK2 1100delC was present in 3 of the 71 (4.2%) unselected MBC cases, which was significantly more prevalent than the 1.1% Dutch population frequency assessed in 1,692 individuals (P = 0.05, OR = 4.1, 95% CI 1.2-14.3). Our data suggest that, in the Netherlands, CHEK2 1100delC is associated with an increased risk for MBC.

Prevalence of GJB2 (connexin-26) and GJB6 (connexin-30) mutations in a cohort of 300 Brazilian hearing-impaired individuals: implications for diagnosis and genetic counseling.

PubMed

Batissoco, Ana Carla; Abreu-Silva, Ronaldo Serafim; Braga, Maria Cristina Célia; Lezirovitz, Karina; Della-Rosa, Valter; Alfredo, Tabith; Otto, Paulo Alberto; Mingroni-Netto, Regina Célia

2009-02-01

Hereditary nonsyndromic deafness is an autosomal recessive condition in about 80% of cases, and point mutations in the GJB2 gene (connexin 26) and two deletions in the GJB6 gene (connexin 30), del(GJB6-D13S1830) and del(GJB6-D13S1854), are reported to account for 50% of recessive deafness. Aiming at establishing the frequencies of GJB2 mutations and GJB6 deletions in the Brazilian population, we screened 300 unrelated individuals with hearing impairment, who were not affected by known deafness related syndromes. We firstly screened the most frequently reported mutations, c.35delG and c.167delT in the GJB2 gene, and del(GJB6-D13S1830) and del(GJB6-D13S1854) in the GJB6 gene, through specific techniques. The detected c.35delG and c.167delT mutations were validated by sequencing. Other mutations in the GJB2 gene were screened by single-strand conformation polymorphism and the coding region was sequenced when abnormal patterns were found. Pathogenic mutations in GJB2 and GJB6 genes were detected in 41 individuals (13.7%), and 80.5% (33/41) presented these mutations in homozygosis or compound heterozygosis, thus explaining their hearing defect. The c.35delG in the GJB2 gene was the most frequent mutation (37/300; 12.4%), detected in 23% familial and 6.2% the sporadic cases. The second most frequent mutation (1%; 3/300) was the del(GJB6-D13S1830), always found associated with the c.35delG mutation. Nineteen different sequence variations were found in the GJB2 gene. In addition to the c.35delG mutation, nine known pathogenic alterations were detected c.167delT, p.Trp24X, p.Val37Ile, c.176_191del16, c.235delC, p.Leu90Pro, p.Arg127His, c.509insA, and p.Arg184Pro. Five substitutions had been previously considered benign polymorphisms: c.-15C>T, p.Val27Ile, p.Met34Thr, p.Ala40Ala, and p.Gly160Ser. Two previously reported mutations of unknown pathogenicity were found (p.Lys168Arg, and c.684C>A), and two novel substitutions, p.Leu81Val (c.G241C) and p.Met195Val (c.A583G), both in heterozygosis without an accompanying mutation in the other allele. None of these latter four variants of undefined status was present in a sample of 100 hearing controls. The present study demonstrates that mutations in the GJB2 gene and del(GJB6 D13S1830) are important causes of hearing impairment in Brazil, thus justifying their screening in a routine basis. The diversity of variants in our sample reflects the ethnic heterogeneity of the Brazilian population.

Sistema Planeta-Satélite. Simulación orbital y potenciales gravitatorios

NASA Astrophysics Data System (ADS)

Medina, C.; Carrillo, M.

Se presenta un programa (desarrollado en Quick Basic 4.5) que simula, en tres dimensiones, el movimiento orbital de un satélite (o luna) alrededor de un planeta, al tiempo que calcula y grafica, en un plano, el potencial gravitatorio del sistema en función de la distancia al planeta. Para la simulación orbital, se emplea la matriz de transformación entre el sistema del planeta y el plano orbital. Para el cálculo y graficación del potencial se aplica un desarrollo en serie hasta el segundo orden, que da cuenta del efecto de achatamiento de los polos, en caso de que éste exista. Las longitudes de los ejes del planeta, la masa de éste y del satélite, sus tamaños aparentes, y los parámetros orbitales son introducidos por el usuario.

International Celestial Reference Frame (ICRF): mantenimiento y extensión

NASA Astrophysics Data System (ADS)

Ma, C.; Arias, E. F.; Eubanks, T.; Fey, A. L.; Gontier, A.-M.; Jacobs, C. S.; Sovers, O. J.; Archinal, B. A.; Charlot, P.

A partir de enero de 1998 el sistema de referencia celeste convencional está representado por el International Celestial Reference System (ICRS) y materializado a través de las coordenadas VLBI del conjunto de radiofuentes extragalácticas que conforman el International Celestial Reference Frame (ICRF). La primera realización del ICRF, fue elaborada en 1995 por un grupo de expertos designado por la IAU, la que encomendó al International Earth Rotation Service el mantenimiento del ICRS, del ICRF y del vínculo con marcos de referencia en otras frecuencias. Una primera extensión del ICRF se realizó entre abril y junio de 1999, con el objetivo primario de proveer posiciones de radiofuentes extragalácticas observadas a partir de julio de 1995 y de mejorar las posiciones de las fuentes ``candidatas" con la inclusión de observaciones adicionales. Objetivos secundarios fueron monitorear a las radiofuentes para verificar que siguen siendo adecuadas para realizar al ICRF y mejorar las técnicas de análisis de datos. Como resultado del nuevo análisis se obtuvo una solución a partir de la cual se construyó la primera extensión del ICRF, denominada ICRF - Ext.1. Ella representa al ICRS, sus fuentes de definición se mantienen con las mismas posiciones y errores que en la primera realización del ICRF; las demás radiofuentes tienen coordenadas mejor determinadas que en ICRF; el marco de referencia se densificó con el agregado de 59 nuevas radiofuentes.

Estimaciones de Prevalencia del VIH por Género y Grupo de Riesgo en Tijuana, México: 2006

PubMed Central

Iñiguez-Stevens, Esmeralda; Brouwer, Kimberly C.; Hogg, Robert S.; Patterson, Thomas L.; Lozada, Remedios; Magis-Rodriguez, Carlos; Elder, John P.; Viani, Rolando M.; Strathdee, Steffanie A.

2010-01-01

OBJETIVO Estimar la prevalencia del VIH en adultos de 15-49 años de edad en Tijuana, México - en la población general y en subgrupos de riesgo en el 2006. METODOS Se obtuvieron datos demográficos del censo Mexicano del 2005, y la prevalencia del VIH se obtuvo de la literatura. Se construyó un modelo de prevalencia del VIH para la población general y de acuerdo al género. El análisis de sensibilidad consistió en estimar errores estándar del promedio-ponderado de la prevalencia del VIH y tomar derivados parciales con respecto a cada parámetro. RESULTADOS La prevalencia del VIH es 0.54%(N = 4,347) (Rango: 0.22%–0.86%, (N = 1,750–6,944)). Esto sugiere que 0.85%(Rango: 0.39%–1.31%) de los hombres y 0.22%(Rango: 0.04%–0.40%) de las mujeres podrían ser VIH-positivos. Los hombres que tienen sexo con hombres (HSH), las trabajadoras sexuales usuarias de drogas inyectables (MTS-UDI), MTS-noUDI, mujeres UDI, y los hombres UDI contribuyeron las proporciones más elevadas de personas infectadas por el VIH. CONCLUSIONES El número de adultos VIH-positivos entre subgrupos de riesgo en la población de Tijuana es considerable, marcando la necesidad de enforcar las intervenciones de prevención en sus necesidades específicas. El presente modelo estima que hasta 1 en cada 116 adultos podrían ser VIH-positivos. PMID:19685824

Forensic applicability of multi-allelic InDels with mononucleotide homopolymer structures.

PubMed

Zhang, Shu; Zhu, Qiang; Chen, Xiaogang; Zhao, Yuancun; Zhao, Xiaohong; Yang, Yiwen; Gao, Zehua; Fang, Ting; Wang, Yufang; Zhang, Ji

2018-04-27

Insertion/deletion polymorphisms (InDels), which possess the characteristics of low mutation rates and a short amplicon size, have been regarded as promising markers for forensic DNA analysis. InDels can be classified as bi-allelic or multi-allelic, depending on the number of alleles. Many studies have explored the use of bi-allelic InDels in forensic applications, such as individual identification and ancestry inference. However, multi-allelic InDels have received relatively little attention. In this study, InDels with 2-6 alleles and a minor allele frequency ≥0.01, in Chinese Southern Han (CHS), were retrieved from the 1000 Genomes Project Phase III. Based on the structural analysis of all retrieved InDels, 17 multi-allelic markers with mononucleotide homopolymer structures were selected and combined in one multiplex PCR reaction system. Sensitivity, species specificity and applicability in forensic case work of the multiplex were analyzed. A total of 218 unrelated individuals from a Chinese Han population were genotyped. The combined discriminatory power (CDP), the combined match probability (CMP) and the cumulative probability of exclusion (CPE) were 0.9999999999609, 3.91E-13 and 0.9956, respectively. The results demonstrated that this InDel multiplex panel was highly informative in the investigated population and most of the 26 populations of the 1000 Genomes Project. The data also suggested that multi-allelic InDel markers with monomeric base pair expansions are useful for forensic applications. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Microwave Observations and Modeling of O2 (1-delta(sub g)) and O3 Diurnal Variation in the Mesosphere

NASA Technical Reports Server (NTRS)

Sandor, Brad J.; Clancy, R. Todd; Rusch, David W.; Randall, Cora E.; Eckman, Richard S.; Siskind, David S.; Muhleman, Duane O.

1997-01-01

The first microwave measurements of an electronically excited molecular species in the Earth's atmosphere are presented. Local thermodynamic equilibrium (LTE) rotational line emission from mesospheric O2(1-del(sub g)) was observed at a frequency of 255.01794 GHz (lambda is approx. 1.2 mm), employing the National Radio Astronomy Observatory (NRAO) millimeter facility at Kitt Peak, Arizona (32 N, 111 W). The pressure broadened line shapes of the O2(1-del(sub g)) spectra, which were obtained in January and April 1992 and in January and November 1993, are inverted to retrieve O2(1-del(sub g)) mixing profiles over the 50-70 km altitude region. The observed daytime abundances exceed ozone abundances in the lower mesosphere, which are separately retrieved with coincident O3 spectral line (249.7886 GHz) observations. The January and November 1993 observations are binned into 20-60 min time intervals to study O2(1-del(sub g)) diurnal behavior. Derived abundances of O2(1-del(sub g)) between 50 and 70 km for the four observation dates are 9%, 31%, 3%, and 26%, respectively, each +/- 10% higher than predicted, based on the simple photochemistry of lower mesospheric O2(1-del(sub g)). Modeled variation of [O2(1-del(sub g))] with time of day agrees with observed variation in that the observed difference between model and data abundances is constant throughout the daylight hours of each observation date. Model underprediction Of [02(lAg)] is consistent with similar model underprediction of mesospheric [O3]. A perturbation to the photochemical model that forces decreased ozone chemical loss brings brings both model [O3] and [O2(1-del(sub g))] into agreement with the observations. O2(1-del(sub g)) abundances derived from these 1.2 mm observations agree with [O2(1-del(sub g))] values derived from comparable SME observations of the 1.27 micrometers emission, with assumption of a 3880 sec O2(1-del(sub g)) radiative lifetime. The 6800 sec O2(1-del(sub g)) radiative lifetime proposed by Mlynczak and Nesbitt is ruled out by the similar comparison.

Tierra del Fuego, Argentina, South America

NASA Technical Reports Server (NTRS)

1991-01-01

The Mitre Peninsula is the easternmost tip of Tierra del Fuego, Argentina, (54.5S, 65.5W). Early winter snow can be seen on this south tip of the Andes Mountains. These same mountains continue underwater to Antarctica. The Strait of Magellan, separating the South American mainland from Tierra del Fuego is off the scene to the north and west, but the Strait of LeMaire, separating Tierra del Fuego from the Isla de los Estados can be seen.

Desgarros del epitelio pigmentario de la retina: factores de riesgo, mecanismo y control terapéutico.

PubMed

Clemens, Christoph R; Eter, Nicole

2017-07-11

Los desgarros del epitelio pigmentario de la retina (EPR) se asocian en la mayoría de los casos con los desprendimientos vascularizados del EPR debido a una degeneración macular asociada a la edad (DMAE), y normalmente implican una pérdida adversa de la agudeza visual. Estudios recientes indican que ha habido un aumento en la incidencia de desgarros del EPR desde la introducción de fármacos anti-factor de crecimiento del endotelio vascular (anti-VEGF) así como una asociación temporal entre el desgarro y la inyección intravítrea. Dado que el número de pacientes con DMAE y el número de inyecciones anti-VEGF va en aumento, tanto la dificultad de prevenir desgarros del EPR como el tratamiento tras la formación de los desgarros han adquirido una mayor relevancia. De forma paralela, la evolución de la imagenología de la retina ha contribuido de manera significativa a comprender mejor el desarrollo de los desgarros del EPR en los últimos años. Esta revisión resume los conocimientos que se poseen actualmente sobre el desarrollo, los factores pronósticos y las estrategias terapéuticas de los desgarros del EPR antes y después de que estos se formen. © 2017 S. Karger AG, Basel.

[Play as a care strategy for children with cancer].

PubMed

Lima, Kálya Yasmine Nunes de; Santos, Viviane Euzébia Pereira

2015-06-01

To understand the influence of play in the care process as perceived by children with cancer. A descriptive, exploratory and qualitative study conducted in a children's cancer unit in Natal, Rio Grande do Norte, Brazil. Data were collected between October 2013 and January 2014 by means of photographic records and semi-structured interviews with eight children, and content analysis with emphasis on two categories: Auxiliary instruments during play; and The influence of play in the process of care. Recreational activities involve watching television, using computers, games and toys, drawing, the playroom and the clown, which provide fun, feelings of joy, distraction and interaction with other people. There are several activities at the hospital that are considered play-related and, for the children, they all benefit their care process.

[The remittances in U.S. dollars that Mexican migrants send home from the United States (a study based on data from the Survey of Migration in the Northern Frontier Region of Mexico)].

PubMed

Corona Vasquez, R

1998-01-01

The difficulties in obtaining reliable data on remittances to Mexico by Mexican immigrants in the United States are first outlined. An analysis of such remittances is then attempted using data from a recent survey, the Encuesta sobre Migracion en la Frontera Norte. Data from this survey are used to analyze several aspects of remittances "such as the direct determination of the amount of the remittances and the identification of the immigrants that send them according to their social and demographic features, and the location of Mexican zones where the remittances arrive, [and] the variations in the amount and frequency of the remittances among the different groups of immigrants." (EXCERPT)

Maps showing anomaly patterns for silver, molybdenum, lead, and zinc in altered rocks and soils, Williams Fork and St. Louis Peak Roadless Areas, Clear Creek, Grand, and Summit counties, Colorado

USGS Publications Warehouse

Eppinger, R.G.; Theobald, P.K.; Barton, H.N.; Carlson, R.R.

1985-01-01

The U.S. Geological Survey and the U.S Bureau of Mines conducted field studies from 1979 through 1982 to assess the mineral resource potential of the Williams Fork and St. Louis Peak Roadless Areas and the Vasquez Peak Wilderness Study Area.  Included were geological, geochemical, and geophysical studies by the U.S. Geological Survey and investigation of known prospects and mines by the U.S. Bureau of Mines.  The area of study is located in the Arapaho National Forest, nort of Interstate Highway 70, west of U.S. Highway 40, and east of the Blue River, on the west side of the Front Range (fig. 1).

[Possibilities and limits of sleep recovery for night-nursing workers].

PubMed

de Medeiros, Soraya Maria; de Macêdo, Maria Lúcia Azevedo Ferreira; de Oliveira, Jonas Sâmi Albuquerque; Ribeiro, Laiane Medeiros

2009-03-01

The present study had the objective of investigating the possibilities/limits of sleep recovery in women workers with medium level in nursing that develop their activities in night shifts in a first-aid clinic at a public hospital in Natal, Rio Grande do Norte, Brazil. This was an analytic study, with a qualitative approach which used the technique of thematic oral history Fifteen women workers with medium level in nursing were interviewed. The following empirical categories were defined: night shift work and night sleep and night rest at work environment Physiological and psychological sufferings are evident on their speech as well as what the lack of sleep causes in health and personal life of these women workers, making the overload of work clear and also the sociocultural imperfections of feminine gender

Tungsten resources of Brazil

USGS Publications Warehouse

White, Max Gregg

1974-01-01

Brazilian tungsten production, 85 percent of which is exported, comes almost entirely from scheelite-bearing tactites in northeast Brazil, and has reached an annual rate of about 2,000 metric tons (2,200 short tons) of scheelite concentrate with 70 percent WO3. Scheelite ore reserves, located principally in the State of Rio Grande do Norte, are estimated to be as high as 8,300,000 tons (9,100,000 short tons) containing 0.7 percent WO3. Minor deposits (or those about which only minimal information is available) of wolframite, with which some cassiterite is associated, are located in Sao Paulo, Santa Catarina, and Rio Grande do Sul. Both the scheelite and the wolframite deposits are considered . to be late Precambrian A (620 to 900 m.y.) or early Cambrian in age.

[Chronic health conditions related to quality of life for federal civil servants].

PubMed

Saraiva, Luciana Eduardo Fernandes; Medeiros, Lays Pinheiro de; Melo, Marjorie Dantas Medeiros; Tiburcio, Manuela Pinto; Costa, Isabelle Katherinne Fernandes; Torres, Gilson de Vasconcelos

2015-06-01

The aim of this study is to correlate the QOL domains of the civil servants to the type and number of chronic health conditions. A transversal, quantitative study, conducted at the Department of Civil Servant Assistance of the Federal University of Rio Grande do Norte with 215 civil servants, during the period from March to May 2011. Among the chronic health conditions studied, there was significant relationship between non-communicable chronic disease and QOL scores, correlating weakly (r <-376; p <0.008) in the other fields. It was found that the greater the number of chronic conditions, the lower the values on the QOL scale. The quality of life of civil servants is negatively influenced by chronic health conditions, compromising, in general, their daily work and life activities.

Índice UV

EPA Pesticide Factsheets

Información general sobre el Índice UV que proporciona un pronóstico del riesgo esperado de sobreexposición a la radiación ultravioleta (UV) del sol. El índice UV va acompañado de recomendaciones para protegerse del sol.

The Douro estuarine plume: Detection, processes and dynamics =

NASA Astrophysics Data System (ADS)

Mendes, Renato Paulo dos Santos

O Douro e um dos maiores rios da Peninsula Iberica, constituindo a maior descarga de agua doce para o Oceano Atlântico na costa noroeste portuguesa. A sua pluma estuarina tem particular relevância na dinâmica costeira e na modulacao de fenomenos biogeoquimicos. Sao objetivos desta dissertacao contribuir para a compreensao dos processos fisicos associados a geracao e propagacao da pluma estuarina do Rio Douro no oceano, assim como para o conhecimento dos seus padroes de dispersao e da forma como estes alteram a hidrologia e a circulacao costeira, considerando os agentes forcadores tipicos deste fenomeno (caudal fluvial, vento e mare) e indices climaticos relevantes. Para concretizacao destes objetivos foram desenvolvidas e aplicadas metodologias inovadoras de processamento de dados de detecao remota, assim como novas implementacoes estuarinas e costeiras de modelos numericos. Atraves de imagens MODIS, otimizadas para o estudo de fenomenos costeiros, efetuou-se uma detecao rigorosa da pluma. Identificou-se uma relacao entre o sinal turbido nLw555 e o caudal, demonstrando-se este produto como um bom proxy para a observacao da pluma no oceano. As escalas temporais e espaciais da pluma foram caraterizadas atraves destas imagens, combinadas com dados de caudal fluvial, mare, vento e precipitacao, e tambem com indices climaticos relevantes. Para compreender a propagacao da pluma e caracterizar a sua dinâmica e impacto na circulacao costeira, foi desenvolvida uma aplicacao 3D de modelos estuarinos e costeiros com malhas aninhadas de resolucao variavel. Definiramse e analisaram-se diferentes cenarios de vento e descarga fluvial. A interacao da pluma do Rio Douro e do Minho foi ainda analisada atraves dos resultados de simulacoes baseadas num evento de inverno. Os compositos turbidos mostraram que a pluma e facilmente detetada quando o caudal e maior que 500 m3 s??1. A descarga fluvial e o vento sao os principais forcadores da sua propagacao, enquanto a mare e apenas importante na regiao proxima a embocadura do estuario. Observaram-se relacoes a uma escala interanual entre a turbidez da pluma e os indices climaticos East Atlantic e NAO, com uma correlacao maxima identificada com 1 e 3 meses de desfasamento, respetivamente. Com base nos resultados das simulacoes efetuadas, a pluma e classificada como de larga escala e de advecao superficial, apresentando caracteristicas de uma pluma prototipica. Em condicoes de caudal moderado a elevado, a descarga estuarina e suficiente para gerar uma corrente costeira para norte sem acao do vento. Em eventos de ventos leste, a propagacao da pluma e similar ao caso sem vento, com um aumento da velocidade da corrente. Uma corrente costeira para sul e unicamente identificada sob condicoes de forte vento de oeste. Ventos de norte tendem a estender a pluma para o largo, com uma inclinacao na direcao sudoeste, enquanto ventos de sul intensificam a corrente para norte, sendo a mistura das plumas do Douro e do Minho uma consequencia possivel. A analise desta interacao apontou a contribuicao do Douro como importante na estabilizacao da WIBP e nas trocas de agua entre o oceano e as Rias Baixas. A interacao da pluma do Douro com estuarios localizados a sul da sua foz e a confirmacao in situ da recirculacao observada nos resultados numericos afiguram-se como temas relevantes para investigacoes futuras. None

Genetic deletion of keratin 8 corrects the altered bone formation and osteopenia in a mouse model of cystic fibrosis.

PubMed

Le Henaff, Carole; Faria Da Cunha, Mélanie; Hatton, Aurélie; Tondelier, Danielle; Marty, Caroline; Collet, Corinne; Zarka, Mylène; Geoffroy, Valérie; Zatloukal, Kurt; Laplantine, Emmanuel; Edelman, Aleksander; Sermet-Gaudelus, Isabelle; Marie, Pierre J

2016-04-01

Patients with cystic fibrosis (CF) display low bone mass and alterations in bone formation. Mice carrying the F508del genetic mutation in the cystic fibrosis conductance regulator (Cftr) gene display reduced bone formation and decreased bone mass. However, the underlying molecular mechanisms leading to these skeletal defects are unknown, which precludes the development of an efficient anti-osteoporotic therapeutic strategy. Here we report a key role for the intermediate filament protein keratin 8 (Krt8), in the osteoblast dysfunctions in F508del-Cftr mice. We found that murine and human osteoblasts express Cftr and Krt8 at low levels. Genetic studies showed that Krt8 deletion (Krt8(-/-)) in F508del-Cftr mice increased the levels of circulating markers of bone formation, corrected the expression of osteoblast phenotypic genes, promoted trabecular bone formation and improved bone mass and microarchitecture. Mechanistically, Krt8 deletion in F508del-Cftr mice corrected overactive NF-κB signaling and decreased Wnt-β-catenin signaling induced by the F508del-Cftr mutation in osteoblasts. In vitro, treatment with compound 407, which specifically disrupts the Krt8-F508del-Cftr interaction in epithelial cells, corrected the abnormal NF-κB and Wnt-β-catenin signaling and the altered phenotypic gene expression in F508del-Cftr osteoblasts. In vivo, short-term treatment with 407 corrected the altered Wnt-β-catenin signaling and bone formation in F508del-Cftr mice. Collectively, the results show that genetic or pharmacologic targeting of Krt8 leads to correction of osteoblast dysfunctions, altered bone formation and osteopenia in F508del-Cftr mice, providing a therapeutic strategy targeting the Krt8-F508del-CFTR interaction to correct the abnormal bone formation and bone loss in cystic fibrosis. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation.

PubMed

Herrera, Alex F; Mei, Matthew; Low, Lawrence; Kim, Haesook T; Griffin, Gabriel K; Song, Joo Y; Merryman, Reid W; Bedell, Victoria; Pak, Christine; Sun, Heather; Paris, Tanya; Stiller, Tracey; Brown, Jennifer R; Budde, Lihua E; Chan, Wing C; Chen, Robert; Davids, Matthew S; Freedman, Arnold S; Fisher, David C; Jacobsen, Eric D; Jacobson, Caron A; LaCasce, Ann S; Murata-Collins, Joyce; Nademanee, Auayporn P; Palmer, Joycelynne M; Pihan, German A; Pillai, Raju; Popplewell, Leslie; Siddiqi, Tanya; Sohani, Aliyah R; Zain, Jasmine; Rosen, Steven T; Kwak, Larry W; Weinstock, David M; Forman, Stephen J; Weisenburger, Dennis D; Kim, Young; Rodig, Scott J; Krishnan, Amrita; Armand, Philippe

2017-01-01

Purpose Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are subtypes of diffuse large B-cell lymphoma (DLBCL) associated with poor outcomes after standard chemoimmunotherapy. Data are limited regarding outcomes of patients with relapsed or refractory (rel/ref) DEL or DHL who undergo autologous stem-cell transplantation (ASCT). We retrospectively studied the prognostic impact of DEL and DHL status on ASCT outcomes in patients with rel/ref DLBCL. Methods Patients with chemotherapy-sensitive rel/ref DLBCL who underwent ASCT at two institutions and in whom archival tumor material was available were enrolled. Immunohistochemistry for MYC, BCL2, and BCL6 and fluorescence in situ hybridization (FISH) for MYC were performed. In cases with MYC rearrangement or copy gain, FISH for BCL2 and BCL6 was also performed. Results A total of 117 patients were included; 44% had DEL and 10% had DHL. DEL and DHL were associated with inferior progression-free survival (PFS), and DHL was associated with poorer overall survival (OS). The 4-year PFS in patients with DEL compared with those with non-DEL was 48% versus 59% ( P = .049), and the 4-year OS was 56% versus 67% ( P = .10); 4-year PFS in patients with DHL compared with those with non-DHL was 28% versus 57% ( P = .013), and 4-year OS was 25% versus 61% ( P = .002). The few patients with concurrent DEL and DHL had a poor outcome (4-year PFS, 0%). In multivariable models, DEL and DHL were independently associated with inferior PFS, whereas DHL and partial response ( v complete response) at transplant were associated with inferior OS. Conclusion DEL and DHL are both associated with inferior outcomes after ASCT in patients with rel/ref DLBCL. Although ASCT remains a potentially curative approach, these patients, particularly those with DHL, are a high-risk subset who should be targeted for investigational strategies other than standard ASCT.

Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation

PubMed Central

Herrera, Alex F.; Mei, Matthew; Low, Lawrence; Kim, Haesook T.; Griffin, Gabriel K.; Song, Joo Y.; Merryman, Reid W.; Bedell, Victoria; Pak, Christine; Sun, Heather; Paris, Tanya; Stiller, Tracey; Brown, Jennifer R.; Budde, Lihua E.; Chan, Wing C.; Chen, Robert; Davids, Matthew S.; Freedman, Arnold S.; Fisher, David C.; Jacobsen, Eric D.; Jacobson, Caron A.; LaCasce, Ann S.; Murata-Collins, Joyce; Nademanee, Auayporn P.; Palmer, Joycelynne M.; Pihan, German A.; Pillai, Raju; Popplewell, Leslie; Siddiqi, Tanya; Sohani, Aliyah R.; Zain, Jasmine; Rosen, Steven T.; Kwak, Larry W.; Weinstock, David M.; Forman, Stephen J.; Weisenburger, Dennis D.; Kim, Young; Rodig, Scott J.; Krishnan, Amrita

2017-01-01

Purpose Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are subtypes of diffuse large B-cell lymphoma (DLBCL) associated with poor outcomes after standard chemoimmunotherapy. Data are limited regarding outcomes of patients with relapsed or refractory (rel/ref) DEL or DHL who undergo autologous stem-cell transplantation (ASCT). We retrospectively studied the prognostic impact of DEL and DHL status on ASCT outcomes in patients with rel/ref DLBCL. Methods Patients with chemotherapy-sensitive rel/ref DLBCL who underwent ASCT at two institutions and in whom archival tumor material was available were enrolled. Immunohistochemistry for MYC, BCL2, and BCL6 and fluorescence in situ hybridization (FISH) for MYC were performed. In cases with MYC rearrangement or copy gain, FISH for BCL2 and BCL6 was also performed. Results A total of 117 patients were included; 44% had DEL and 10% had DHL. DEL and DHL were associated with inferior progression-free survival (PFS), and DHL was associated with poorer overall survival (OS). The 4-year PFS in patients with DEL compared with those with non-DEL was 48% versus 59% (P = .049), and the 4-year OS was 56% versus 67% (P = .10); 4-year PFS in patients with DHL compared with those with non-DHL was 28% versus 57% (P = .013), and 4-year OS was 25% versus 61% (P = .002). The few patients with concurrent DEL and DHL had a poor outcome (4-year PFS, 0%). In multivariable models, DEL and DHL were independently associated with inferior PFS, whereas DHL and partial response (v complete response) at transplant were associated with inferior OS. Conclusion DEL and DHL are both associated with inferior outcomes after ASCT in patients with rel/ref DLBCL. Although ASCT remains a potentially curative approach, these patients, particularly those with DHL, are a high-risk subset who should be targeted for investigational strategies other than standard ASCT. PMID:28034071

Naturally occurring deletions/insertions in HBV core promoter tend to decrease in hepatitis B e antigen-positive chronic hepatitis B patients during antiviral therapy.

PubMed

Peng, Yaqin; Liu, Baoming; Hou, Jinlin; Sun, Jian; Hao, Ran; Xiang, Kuanhui; Yan, Ling; Zhang, Jiangbo; Zhuang, Hui; Li, Tong

2015-01-01

Mutations in HBV core promoter (CP) are suggested to affect viral replication and disease progression. We investigated CP deletion/insertion mutations (Del/Ins) in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients before and during antiviral treatment. Direct and clone sequencings were used for detection of CP Del/Ins in 12 patients. The dynamic changes of CP Del/Ins were tracked in these cases until week 48 of treatment. The effects of Del/Ins on CP activities and hepatitis B X protein (HBx) were analysed using luciferase assay and sequence comparison, respectively. Furthermore, 292 untreated HBeAg-positive CHB cases were also analysed. Twelve cases with multi-peak PCR direct sequencing electropherograms at baseline were confirmed to have CP Del/Ins by clone sequencing, with detection rates varying from 14.8% to 93.3% of clones analysed. Follow-up studies showed the detection rates of CP Del/Ins in patients decreased from 100% (12/12) at baseline to 16.7% (2/12) at week 48 of treatment (P<0.001), in parallel with a decline in HBV DNA, hepatitis B surface antigen (HBsAg), alanine aminotransferase (ALT) and aspartate transaminase (AST) levels along with an increase in HBeAg loss. Luciferase assay results showed distinct promoter activities among Del/Ins-harbouring CP sequences. Importantly, 71.8% (148/206) of Del/Ins sequences potentially resulted in HBx carboxy-terminal truncations. CP Del/Ins mutations were also found in 27.4% (80/292) of untreated cases. Naturally occurring complex of CP Del/Ins mutants existed in untreated HBeAg-positive CHB patients. These mutations would affect HBV transcription activities and integrity of HBx, which might correlate with disease progression. Their prevalence decreases on antiviral therapy in parallel with the decline in HBV DNA, HBsAg and ALT and AST levels.

CONTAMINACIÓN AMBIENTAL, VARIABILIDAD CLIMÁTICA Y CAMBIO CLIMÁTICO: UNA REVISIÓN DEL IMPACTO EN LA SALUD DE LA POBLACIÓN PERUANA

PubMed Central

Gonzales, Gustavo F.; Zevallos, Alisson; Gonzales-Castañeda, Cynthia; Nuñez, Denisse; Gastañaga, Carmen; Cabezas, César; Naeher, Luke; Levy, Karen; Steenland, Kyle

2015-01-01

RESUMEN El presente artículo es una revisión sobre la contaminación del agua, el aire y el efecto del cambio climático en la salud de la población peruana. Uno de los principales contaminantes del aire es el material particulado menor de 2,5 μ (PM 2,5), en la ciudad de Lima, anualmente 2300 muertes prematuras son atribuibles a este contaminante. Otro problema es la contaminación del aire domiciliario por el uso de cocinas con combustible de biomasa, donde la exposición excesiva a PM 2,5 dentro de las casas es responsable de aproximadamente 3000 muertes prematuras anuales entre adultos, con otro número desconocido de muertes entre niños debido a infecciones respiratorias. La contaminación del agua tiene como principales causas los desagües vertidos directamente a los ríos, minerales (arsénico) de varias fuentes, y fallas de las plantas de tratamiento. En el Perú, el cambio climático puede impactar en la frecuencia y severidad del fenómeno de El Niño oscilación del sur (ENSO) que se ha asociado con un incremento en los casos de enfermedades como cólera, malaria y dengue. El cambio climático incrementa la temperatura y puede extender las áreas afectadas por enfermedades transmitidas por vectores, además de tener efecto en la disponibilidad del agua y en la contaminación del aire. En conclusión, el Perú, pasa por una transición de factores de riesgo ambientales, donde coexisten riesgos tradicionales y modernos, y persisten los problemas infecciosos y crónicos, algunos de los cuales se asocian con problemas de contaminación de agua y de aire. PMID:25418656

CDC25AQ110del: A Novel Cell Division Cycle 25A Isoform Aberrantly Expressed in Non-Small Cell Lung Cancer

PubMed Central

Younis, Rania H.; Cao, Wei; Lin, Ruxian; Xia, Ronghui; Liu, Zhenqiu; Edelman, Martin J.; Mei, Yuping; Mao, Li; Ren, Hening

2012-01-01

Objective Lung cancer remains number one cause of cancer related deaths worldwide. Cell cycle deregulation plays a major role in the pathogenesis of Non-Small Cell Lung Cancer (NSCLC). CDC25A represents a critical cell cycle regulator that enhances cell cycle progression. In this study we aimed to investigate the role of a novel CDC25A transcriptional variant, CDC25AQ110del, on the regulation of the CDC25A protein, and its impact on prognosis of NSCLC patients. Methodology/Principal Findings Here we report a novel CDC25A transcript variant with codon 110 (Glutamine) deletion, that we termed CDC25AQ110del in NSCLC cells. In 9 (75%) of the 12 NSCLC cell lines, CDC25AQ110del expression accounted for more than 20% of the CDC25A transcripts. Biological effects of CDC25AQ110del were investigated in H1299 and HEK-293F cells using UV radiation, flowcytometry, cyclohexamide treatment, and confocal microscopy. Compared to CDC25Awt, CDC25AQ110del protein had longer half-life; cells expressing CDC25AQ110del were more resistant to UV irradiation and showed more mitotic activity. Taqman-PCR was used to quantify CDC25AQ110del expression levels in 88 primary NSCLC tumor/normal tissue pairs. In patients with NSCLC, Kaplan Meier curves showed tumors expressing higher levels of CDC25AQ110del relative to the adjacent lung tissues to have significantly inferior overall survival (P = .0018). Significance Here we identified CDC25AQ110del as a novel transcriptional variant of CDC25A in NSCLC. The sequence-specific nature of the abnormality could be a prognostic indicator in NSCLC patients as well as a candidate target for future therapeutic strategies. PMID:23071577

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fang, Xu-Qian; Liu, Xiang-Fan; Yao, Ling

Highlights: •A novel FAK splicing mutation identified in breast tumor. •FAK-Del33 mutation promotes cell migration and invasion. •FAK-Del33 mutation regulates FAK/Src signal pathway. -- Abstract: Focal adhesion kinase (FAK) regulates cell adhesion, migration, proliferation, and survival. We identified a novel splicing mutant, FAK-Del33 (exon 33 deletion, KF437463), in both breast and thyroid cancers through colony sequencing. Considering the low proportion of mutant transcripts in samples, this mutation was detected by TaqMan-MGB probes based qPCR. In total, three in 21 paired breast tissues were identified with the FAK-Del33 mutation, and no mutations were found in the corresponding normal tissues. When introducedmore » into a breast cell line through lentivirus infection, FAK-Del33 regulated cell motility and migration based on a wound healing assay. We demonstrated that the expression of Tyr397 (main auto-phosphorylation of FAK) was strongly increased in FAK-Del33 overexpressed breast tumor cells compared to wild-type following FAK/Src RTK signaling activation. These results suggest a novel and unique role of the FAK-Del33 mutation in FAK/Src signaling in breast cancer with significant implications for metastatic potential.« less

Factors associated with poor sleep quality in women with cancer.

PubMed

Mansano-Schlosser, Thalyta Cristina; Ceolim, Maria Filomena

2017-03-02

to analyze the factors associated with poor sleep quality, its characteristics and components in women with breast cancer prior to surgery for removing the tumor and throughout the follow-up. longitudinal study in a teaching hospital, with a sample of 102 women. The following were used: a questionnaire for sociodemographic and clinical characterization, the Pittsburgh Sleep Quality Index; the Beck Depression Inventory; and the Herth Hope Scale. Data collection covered from prior to the surgery for removal of the tumor (T0) to T1, on average 3.2 months; T2, on average 6.1 months; and T3, on average 12.4 months. Descriptive statistics and the Generalized Estimating Equations model were used. depression and pain contributed to the increase in the score of the Pittsburgh Sleep Quality Index, and hope, to the reduction of the score - independently - throughout follow-up. Sleep disturbances were the component with the highest score throughout follow-up. the presence of depression and pain, prior to the surgery, contributed to the increase in the global score of the Pittsburgh Sleep Quality Index, which indicates worse quality of sleep throughout follow-up; greater hope, in its turn, influenced the reduction of the score of the Pittsburgh Sleep Quality Index. analizar los factores asociados a la mala calidad del sueño, sus características y componentes en mujeres con cáncer de mama, antes de la cirugía de retirada del tumor y a lo largo del seguimiento. estudio longitudinal, en hospital universitario con muestra de 102 mujeres. Fueron utilizados: un cuestionario de caracterización sociodemográfica y clínica; el Índice de Calidad del Sueño de Pittsburgh; el Inventario de Depresión de Beck; y la Escala de Esperanza de Herth. La recolección comprendió los momentos: antes de la cirugía de retirada del tumor (T0), en (T1) en promedio 3,2 meses, en (T2) en promedio 6,1 meses y en (T3) en promedio 12,4 meses. Se utilizó estadística descriptiva y el modelo de Ecuaciones de Estimación Generalizada. la depresión y el dolor contribuyeron para el aumento del puntaje del Índice de Calidad del Sueño de Pittsburgh y la esperanza para la reducción del puntaje, de manera independiente, a lo largo del seguimiento. Los trastornos del sueño fueron el componente con puntuación más elevada, a lo largo del seguimiento. la presencia de la depresión y del dolor, previos a la cirugía, contribuyeron para el aumento del puntaje global del Índice de Calidad del Sueño de Pittsburgh, lo que indica peor calidad del sueño, a lo largo del seguimiento y, la mayor esperanza, a su vez, influenció en la reducción del puntaje del Índice de Calidad del Sueño de Pittsburgh. analisar os fatores associados à má qualidade do sono, suas características e componentes em mulheres com câncer de mama antes da cirurgia de retirada do tumor e ao longo do seguimento. estudo longitudinal, em hospital universitário com amostra de 102 mulheres. Foram utilizados: questionário de caracterização sociodemográfica e clínica, Índice de Qualidade do Sono de Pittsburgh; Inventário de Depressão de Beck; Escala de Esperança de Herth. Coleta compreendeu antes da cirurgia de retirada do tumor (T0) em T1, em média 3,2 meses; T2, em média 6,1 meses; T3, em média 12,4 meses. Utilizou-se estatística descritiva e o modelo de Equações de Estimação Generalizada. a depressão e a dor contribuíram para o aumento do escore do Índice de Qualidade de Sono de Pittsburgh, e a esperança, para a redução do escore, de maneira independente, ao longo do seguimento. Os transtornos do sono foram o componente com pontuação mais elevada, ao longo do seguimento. a presença de depressão e de dor, previamente à cirurgia, contribuiu para o aumento do escore global do Índice de Qualidade do Sono de Pittsburgh, o que indica pior qualidade do sono, ao longo do seguimento e, a maior esperança, por sua vez, influenciou na redução do escore do Índice de Qualidade do Sono de Pittsburgh.

Cambios históricos en el aporte terrígeno de la cuenca del Río de la Plata sobre la plataforma interna Uruguaya

NASA Astrophysics Data System (ADS)

Marrero, Analía; Tudurí, Adriana; Pérez, Laura; Cuña, Caroline; Muniz, Pablo; Lopes Figueira, Rubens; Michaelovitch de Mahiques, Michel; Alves de Lima Ferreira, Paulo; Pittauerová, Daniela; Hanebuth, Till; García Rodríguez, Felipe

2014-12-01

El Río de la Plata (RdlP) presenta significativas variaciones naturales (hidrodinámicas y oceanográficas) asociadas a diferentes condiciones climáticas. El propósito de este trabajo es inferir los cambios de aportes continentales de sedimentos y su relación con las variaciones hidrológicas del Río de la Plata, a través del análisis de proxies sedimentológicos y geoquímicos en testigos de sedimentos de la plataforma interna uruguaya que registran los últimos 100 años, aproximadamente. A partir de la datación por 210Pb de dos testigos de sedimentos (GeoB 13813-4 y BAR1) se reconstruyó la geocronología del ambiente, y se relacionó con datos de las forzantes climáticas Pacific Decadal Oscillation, El Niño/La Niña Southern Oscillation, Atlantic Multidecadal Oscillation, y las anomalías hidrológicas de los ríos Paraná y Uruguay. Los valores más positivos y estables del Southern Oscillation Index, los cuales corresponden a fases La Niña, se observan en el periodo correspondiente entre 1910-1970, respecto al resto de la serie, donde se aprecia una mayor variabilidad y una tendencia hacia valores más negativos (eventos El Niño). Se hicieron dendrogramas (clustering) jerárquicos para ambos testigos. Para el testigo GeoB 13813-4, se utilizó la relación Ca/Ti y la granulometría, mientras que para BAR1 se recurrió a variables granulométricas y la tasa de sedimentación. El mayor aporte continental hacia la región de la plataforma adyacente al Río de la Plata registrado a partir del año 1970, podría ser el factor principal de los agrupamientos observados en los clusters para ambos testigos. Las agrupaciones mostraron una diferenciación en la década de 1970, lo que estaría asociado al aumento de los caudales de los ríos Paraná y Uruguay, durante las últimas tres décadas del siglo XX. Por otra parte se observa que la granulometría del testigo BAR1 presentó un mayor tamaño de grano y más variabilidad que en el caso del testigo GeoB 13813-4. También se determinó una mayor acumulación de sedimentos a través del tiempo en el cinturón de barro del Río de la Plata (plataforma continental adyacente), comparado con aquel registrado en la Barra del Indio (límite entre zona intermedia y externa del estuario). Estas diferencias podrían estar relacionadas con la influencia del Río de la Plata, el cual genera un ambiente altamente dinámico sobre la Barra del Indio y un ambiente más estable sobre el cinturón de barro en la plataforma continental.

Reconversion Militar del Ejercito en la Frontera Dominico-Haitiana (Military Restructuring of the Army on the Dominican-Haitian Border)

DTIC Science & Technology

2013-05-22

Estado Mayor del Ejército de EE. UU. en cumplimiento parcial de los requisitos para la obtención del grado de MAESTRÍA EN CIENCIAS Y ARTES...MILITARES Estudios Generales Por MAYOR FELIPE CÉSPEDES TEJERA, EJÉRCITO NACIONAL DOMINICANO Licenciado en Ciencias Sociales, Universidad...ANSI Std. Z39.18 ii MAESTRÍA EN ARTES Y CIENCIAS MILITARES PÁGINA DE APROBACIÓN DE LA TESIS Nombre del Candidato: Mayor Felipe Céspedes Tejera

CHEK2*1100delC Variant and BRCA1/2-Negative Familial Breast Cancer - A Family-Based Genetic Association Study

DTIC Science & Technology

2007-10-01

AD_________________ Award Number: DAMD17-03-1-0774 TITLE: CHEK2 *1100delC Variant and BRCA1/2...NUMBER CHEK2 *1100delC Variant and BRCA1/2-Negative Familial Breast Cancer - A Family- Based Genetic Association Study 5b. GRANT NUMBER DAMD17...association between the CHEK2 *1100delC gene variant and breast cancer among BRCA1/2-negative families. Vital to DNA replication and normal growth of breast

Update of the GJB2/DFNB1 mutation spectrum in Russia: a founder Ingush mutation del(GJB2-D13S175) is the most frequent among other large deletions

PubMed Central

Bliznetz, Elena A; Lalayants, Maria R; Markova, Tatiana G; Balanovsky, Oleg P; Balanovska, Elena V; Skhalyakho, Roza A; Pocheshkhova, Elvira A; Nikitina, Natalya V; Voronin, Sergey V; Kudryashova, Elena K; Glotov, Oleg S; Polyakov, Alexander V

2017-01-01

Although mutations in the GJB2 gene sequence make up the majority of variants causing autosomal-recessive non-syndromic hearing loss, few large deletions have been shown to contribute to DFNB1 deafness. Currently, genetic testing for DFNB1 hearing loss includes GJB2 sequencing and DFNB1 deletion analysis for two common large deletions, del(GJB6-D13S1830) and del(GJB6-D13S1854). Here, we report frequency in Russia, clinical significance and evolutionary origins of a 101 kb deletion, del(GJB2-D13S175), recently identified by us. In multiethnic cohort of 1104 unrelated hearing loss patients with biallelic mutations at the DFNB1 locus, the del(GJB2-D13S175) allele frequency of up to 0.5% (11/2208) was determined and this allele was shown to be predominantly associated with profound sensorineural hearing loss. Additionally, eight previously unpublished GJB2 mutations were described in this study. All patients carrying del(GJB2-D13S175) were of the Ingush ancestry. Among normal hearing individuals, del(GJB2-D13S175) was observed in Russian Republic of Ingushetia with a carrier rate of ~1% (2/241). Analysis of haplotypes associated with the deletion revealed a common founder in the Ingushes, with age of the deletion being ~3000 years old. Since del(GJB2-D13S175) was missed by standard methods of GJB2 analysis, del(GJB2-D13S175) detection has been added to our routine testing strategy for DFNB1 hearing loss. PMID:28405014

Effect of the F508del genotype on outcomes of endoscopic sinus surgery in children with cystic fibrosis.

PubMed

Do, Bao Anh Julie; Lands, Larry C; Saint-Martin, Christine; Mascarella, Marco A; Manoukian, John J; Daniel, Sam J; Nguyen, Lily H P

2014-07-01

Numerous authors have sought to describe genotype-phenotype correlations in cystic fibrosis (CF), notably to pancreatic insufficiency and lung disease. However, few studies have focused on the association between the F508del genotype and response to sinus surgery. The objective of this study is to assess the effect of the F508del genotype on sinonasal disease severity and outcomes following functional endoscopic sinus surgery (FESS) in a pediatric population. A retrospective chart review of 153 children with CF seen at a tertiary care pediatric hospital from 1995 to 2008 was performed. Patients were classified into one of three groups according to F508del genotype, either as homozygous, heterozygous or not carrying a F508del mutation. The sinonasal disease phenotype of the three groups was compared based on clinical and radiological findings, extent of endoscopic sinus surgery and rate of revision surgery. The relationship between the F508del genotype and pancreatic insufficiency was confirmed (p<0.05). There was no association between the F508del genotype and increased need for FESS (p=0.75). Moreover, no association was established between F508del homozygosity and presence of nasal polyps, Lund-Mackay score, extent of surgery or length of postoperative hospitalization. The rates of revision surgery did not differ significantly among the three genotypes analyzed (p=0.59). There is no clear association between the F508del genotype and an increased need for FESS, extent of surgery, or revision surgery. Given the phenotypic variability of sinonasal disease in patients with CF, a prospective study is needed to better understand outcomes following FESS and the contribution of gene modifiers to this effect. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

14q deletions are associated with trisomy 12, NOTCH1 mutations and unmutated IGHV genes in chronic lymphocytic leukemia and small lymphocytic lymphoma.

PubMed

Cosson, Adrien; Chapiro, Elise; Belhouachi, Nabila; Cung, Hong-Anh; Keren, Boris; Damm, Frederik; Algrin, Caroline; Lefebvre, Christine; Fert-Ferrer, Sandra; Luquet, Isabelle; Gachard, Nathalie; Mugneret, Francine; Terre, Christine; Collonge-Rame, Marie-Agnes; Michaux, Lucienne; Rafdord-Weiss, Isabelle; Talmant, Pascaline; Veronese, Lauren; Nadal, Nathalie; Struski, Stephanie; Barin, Carole; Helias, Catherine; Lafage, Marina; Lippert, Eric; Auger, Nathalie; Eclache, Virginie; Roos-Weil, Damien; Leblond, Veronique; Settegrana, Catherine; Maloum, Karim; Davi, Frederic; Merle-Beral, Helene; Lesty, Claude; Nguyen-Khac, Florence

2014-08-01

Deletions of the long arm of chromosome 14 [del(14q)] are rare but recurrently observed in mature B-cell neoplasms, particularly in chronic lymphocytic leukemia (CLL). To further characterize this aberration, we studied 81 cases with del(14q): 54 of CLL and 27 of small lymphocytic lymphoma (SLL), the largest reported series to date. Using karyotype and fluorescence in situ hybridization (FISH), the most frequent additional abnormality was trisomy 12 (tri12), observed in 28/79 (35%) cases, followed by del13q14 (12/79, 15%), delTP53 (11/80, 14%) delATM (5/79, 6%), and del6q21 (3/76, 4%). IGHV genes were unmutated in 41/53 (77%) patients, with a high frequency of IGHV1-69 (21/52, 40%). NOTCH1 gene was mutated in 14/45 (31%) patients. There was no significant difference in cytogenetic and molecular abnormalities between CLL and SLL. Investigations using FISH and SNP-array demonstrated the heterogeneous size of the 14q deletions. However, a group with the same del(14)(q24.1q32.33) was identified in 48% of cases. In this group, tri12 (P = 0.004) and NOTCH1 mutations (P = 0.02) were significantly more frequent than in the other patients. In CLL patients with del(14q), median treatment-free survival (TFS) was 27 months. In conclusion, del(14q) is associated with tri12 and with pejorative prognostic factors: unmutated IGHV genes (with over-representation of the IGHV1-69 repertoire), NOTCH1 mutations, and a short TFS. © 2014 Wiley Periodicals, Inc.

Pressure ulcer dressings in critical patients: a cost analysis.

PubMed

Silva, Dinara Raquel Araújo; Bezerra, Sandra Marina Gonçalves; Costa, Jéssica Pereira; Luz, Maria Helena Barros Araújo; Lopes, Vanessa Caminha Aguiar; Nogueira, Lidya Tolstenko

2017-06-12

To assess the direct cost of dressings in pressure ulcer treatment. This was a descriptive observational study conducted at an intensive care unit in the Northeast region of Brazil, between November and December 2015. Data were gathered using the Pressure Ulcer Scale for Healing and a form to characterize and assess costs. Values in Brazilian reais (BRL) were converted into U.S. dollars at the exchange rate of USD 0.26/BRL. Univariate and bivariate analyses were conducted. The sample consisted of 15 patients with at least stage 2 ulcers. There was a significant reduction in costs with dressing materials between the initial and final assessments (p=0.002), with a mean of USD 11.9 (±7.4). The most common topical treatments used were essential fatty acids and papain. Cost reduction was proportional to the stage of pressure ulcer. The role of nurses in creating evidence-based care plans is crucial to improve care management. Avaliar o custo direto com curativos no tratamento de lesões por pressão. Estudo observacional descritivo, realizado em Unidade de Terapia Intensiva do nordeste do Brasil, de novembro a dezembro de 2015. Foi aplicada a Pressure Ulcer Scale for Healing e formulário para caracterização e avaliação de custos. Os valores da moeda brasileira (R$) foram convertidos para a moeda norte-americana (US$) à taxa de US$0,26/R$. Foram realizadas análises univariadas e bivariadas. Compuseram a amostra 15 pacientes com lesões, no mínimo, estágio 2. Houve redução significativa dos custos com materiais de curativos entre as avaliações inicial e final (p=0,002), com média de US$11,9 (±7,4). As terapias tópicas mais frequentes foram ácidos graxos essenciais e papaína. Verificou-se redução de custos proporcional aos estágios das lesões. Enfatiza-se o papel do enfermeiro na elaboração de planos de cuidados baseados em evidências para melhor gerenciamento do cuidado. Evaluar el costo directo de curativos para el tratamiento de lesiones por presión. Estudio observacional descriptivo en la Unidad de Cuidados Intensivos del noreste de Brasil, de noviembre a diciembre del año 2015. Se aplicó la Pressure Ulcer Scale for Healing y formulario para la caracterización y evaluación de los costos. Los valores de la moneda brasileña (Reales- R$) se convirtieron al dólar estadounidense (US$) a razón de $0.26/R$. Se realizaron análisis univariados y bivariados. La muestra consistió en 15 pacientes con lesiones al menos en Etapa 2. Hubo una reducción significativa en el costo de los materiales de curación entre las evaluaciones inicial y final (p=0,002), con un promedio de US$11.9 (±7.4). Los tratamientos tópicos más comunes son los ácidos grasos esenciales y papaína. Se verificó una reducción de los costos proporcional a las etapas de las lesiones. Se hace hincapié en el papel de los enfermeros en el desarrollo de planes de cuidados basados en la evidencia, para una mejor gestión de la atención.

A Rice PECTATE LYASE-LIKE Gene Is Required for Plant Growth and Leaf Senescence1[OPEN

PubMed Central

Leng, Yujia; Yang, Yaolong; Ren, Deyong; Dai, Liping; Wang, Yuqiong; Chen, Long; Tu, Zhengjun; Gao, Yihong; Zhu, Li; Hu, Jiang; Gao, Zhenyu; Guo, Longbiao; Lin, Yongjun

2017-01-01

To better understand the molecular mechanisms behind plant growth and leaf senescence in monocot plants, we identified a mutant exhibiting dwarfism and an early-senescence leaf phenotype, termed dwarf and early-senescence leaf1 (del1). Histological analysis showed that the abnormal growth was caused by a reduction in cell number. Further investigation revealed that the decline in cell number in del1 was affected by the cell cycle. Physiological analysis, transmission electron microscopy, and TUNEL assays showed that leaf senescence was triggered by the accumulation of reactive oxygen species. The DEL1 gene was cloned using a map-based approach. It was shown to encode a pectate lyase (PEL) precursor that contains a PelC domain. DEL1 contains all the conserved residues of PEL and has strong similarity with plant PelC. DEL1 is expressed in all tissues but predominantly in elongating tissues. Functional analysis revealed that mutation of DEL1 decreased the total PEL enzymatic activity, increased the degree of methylesterified homogalacturonan, and altered the cell wall composition and structure. In addition, transcriptome assay revealed that a set of cell wall function- and senescence-related gene expression was altered in del1 plants. Our research indicates that DEL1 is involved in both the maintenance of normal cell division and the induction of leaf senescence. These findings reveal a new molecular mechanism for plant growth and leaf senescence mediated by PECTATE LYASE-LIKE genes. PMID:28455404

A Rice PECTATE LYASE-LIKE Gene Is Required for Plant Growth and Leaf Senescence.

PubMed

Leng, Yujia; Yang, Yaolong; Ren, Deyong; Huang, Lichao; Dai, Liping; Wang, Yuqiong; Chen, Long; Tu, Zhengjun; Gao, Yihong; Li, Xueyong; Zhu, Li; Hu, Jiang; Zhang, Guangheng; Gao, Zhenyu; Guo, Longbiao; Kong, Zhaosheng; Lin, Yongjun; Qian, Qian; Zeng, Dali

2017-06-01

To better understand the molecular mechanisms behind plant growth and leaf senescence in monocot plants, we identified a mutant exhibiting dwarfism and an early-senescence leaf phenotype, termed dwarf and early-senescence leaf1 ( del1 ). Histological analysis showed that the abnormal growth was caused by a reduction in cell number. Further investigation revealed that the decline in cell number in del1 was affected by the cell cycle. Physiological analysis, transmission electron microscopy, and TUNEL assays showed that leaf senescence was triggered by the accumulation of reactive oxygen species. The DEL1 gene was cloned using a map-based approach. It was shown to encode a pectate lyase (PEL) precursor that contains a PelC domain. DEL1 contains all the conserved residues of PEL and has strong similarity with plant PelC. DEL1 is expressed in all tissues but predominantly in elongating tissues. Functional analysis revealed that mutation of DEL1 decreased the total PEL enzymatic activity, increased the degree of methylesterified homogalacturonan, and altered the cell wall composition and structure. In addition, transcriptome assay revealed that a set of cell wall function- and senescence-related gene expression was altered in del1 plants. Our research indicates that DEL1 is involved in both the maintenance of normal cell division and the induction of leaf senescence. These findings reveal a new molecular mechanism for plant growth and leaf senescence mediated by PECTATE LYASE-LIKE genes. © 2017 American Society of Plant Biologists. All Rights Reserved.

Expendable Bathythermograph (XBT) Measurements in the Western Alboran Sea, October 1982

DTIC Science & Technology

1983-08-01

aircraft, shore- based radar, and shore- based meteorological stations cooperated in an intense measurement effort. As one part of this effort USNS BARTLETT...de Castillejo (1972). Contribucion a1 Conocimiento del mar de Alboran: III. Variaciones del Remolino Anticiclonico. Boletin del Institute Espanol

PubMed

Gómez, Luis Alberto; Montoya, Gladis; Rivera, Hernán Mauricio; Hernández, Juan Carlos

2017-04-01

Introducción. El virus del Zika (ZIKV) es un flavivirus con envoltura, transmitido a los seres humanos principalmente por el vector Aedes aegypti. La infección por ZIKV se ha asociado con un gran neurotropismo y con efectos neuropáticos, como el síndrome de Guillain-Barré en el adulto y la microcefalia fetal y posnatal, así como con un síndrome de infección congénita similar al producido por el virus de la rubéola (RV).Objetivo. Comparar las estructuras moleculares de la proteína de envoltura E del virus del Zika (E-ZIKV) y de la E1 del virus de la rubéola (E1-RV), y plantear posibles implicaciones en el neurotropismo y en las alteraciones del sistema nervioso asociadas con el ZIKV.Materiales y métodos. La secuencia de aminoácidos de la proteína E-ZIKV (PDB: 5iZ7) se alineó con la de la glucopreteína E1 del virus de la rubéola (PDB: 4ADG). Los elementos de la estructura secundaria se determinaron usando los programas Vector NTI Advance®, DSSP y POSA, así como herramientas de gestión de datos (AlignX®). Uno de los criterios principales de comparación y alineación fue la asignación de residuos estructuralmente equivalentes, con más de 70 % de identidad.Resultados. La organización estructural de la proteína E-ZIKV (PDB: 5iZ7) fue similar a la de E1-RV (PDB: 4ADG) (70 a 80 % de identidad), y se observó una correspondencia con la estructura definida para las glucoproteínas de fusión de membrana de clase II de los virus con envoltura. E-ZIKV y E1-RV exhibieron elementos estructurales de fusión muy conservados en la región distal del dominio II, asociados con la unión a los receptores celulares de entrada del virus de la rubéola (glucoproteína de mielina del oligodendrocito, Myelin Oligodendrocyte Glycoprotein, MOG), y con los receptores celulares Axl del ZIKV y de otros flavivirus.Conclusión. La comparación de las proteínas E-ZIKV y E1-RV es un paso necesario hacia la definición de otros factores moleculares determinantes del neurotropismo y la patogenia del ZIKV, el cual puede contribuir a generar estrategias de diagnóstico, prevención y tratamiento de las complicaciones neurológicas inducidas por el ZIKV.

Seasonal and inter-annual dynamics of suspended sediment at the mouth of the Amazon river: The role of continental and oceanic forcing, and implications for coastal geomorphology and mud bank formation

NASA Astrophysics Data System (ADS)

Gensac, Erwan; Martinez, Jean-Michel; Vantrepotte, Vincent; Anthony, Edward J.

2016-04-01

Fine-grained sediments supplied to the Ocean by the Amazon River and their transport under the influence of continental and oceanic forcing drives the geomorphic change along the 1500 km-long coast northward to the Orinoco River delta. The aim of this study is to give an encompassing view of the sediment dynamics in the shallow coastal waters from the Amazon River mouth to the Capes region (northern part of the Amapa region of Brazil and eastern part of French Guiana), where large mud banks are formed. Mud banks are the overarching features in the dynamics of the Amazon-Orinoco coast. They start migrating northward in the Capes region. Suspended Particulate Matter (SPM) concentrations were calculated from satellite products (MODIS Aqua and Terra) acquired over the period 2000-2013. The Census-X11 decomposition method used to discriminate short-term, seasonal and long-term time components of the SPM variability has rendered possible a robust analysis of the impact of continental and oceanic forcing. Continental forcing agents considered are the Amazon River water discharge, SPM concentration and sediment discharge. Oceanic forcing comprises modelled data of wind speed and direction, wave height and direction, and currents. A 150 km-long area of accretion is detected at Cabo Norte that may be linked with a reported increase in the river's sediment discharge concurrent with the satellite data study period. We also assess the rate of mud bank migration north of Cabo Norte, and highlight its variability. Although we confirm a 2 km y-1 migration rate, in agreement with other authors, we show that this velocity may be up to 5 km y-1 along the Cabo Orange region, and we highlight the effect of water discharge by major rivers debouching on this coastal mud belt in modulating such rates. Finally, we propose a refined sediment transport pattern map of the region based on our results and of previous studies in the area such as the AMASSEDS programme, and discuss the relationship between sediment transport and accumulation patterns and the coastal geomorphology of this region.

Vegetation fire proneness in Europe

NASA Astrophysics Data System (ADS)

Pereira, Mário; Aranha, José; Amraoui, Malik

2015-04-01

Fire selectivity has been studied for vegetation classes in terms of fire frequency and fire size in a few European regions. This analysis is often performed along with other landscape variables such as topography, distance to roads and towns. These studies aims to assess the landscape sensitivity to forest fires in peri-urban areas and land cover changes, to define landscape management guidelines and policies based on the relationships between landscape and fires in the Mediterranean region. Therefore, the objectives of this study includes the: (i) analysis of the spatial and temporal variability statistics within Europe; and, (ii) the identification and characterization of the vegetated land cover classes affected by fires; and, (iii) to propose a fire proneness index. The datasets used in the present study comprises: Corine Land Cover (CLC) maps for 2000 and 2006 (CLC2000, CLC2006) and burned area (BA) perimeters, from 2000 to 2013 in Europe, provided by the European Forest Fire Information System (EFFIS). The CLC is a part of the European Commission programme to COoRdinate INformation on the Environment (Corine) and it provides consistent, reliable and comparable information on land cover across Europe. Both the CLC and EFFIS datasets were combined using geostatistics and Geographical Information System (GIS) techniques to access the spatial and temporal evolution of the types of shrubs and forest affected by fires. Obtained results confirms the usefulness and efficiency of the land cover classification scheme and fire proneness index which allows to quantify and to compare the propensity of vegetation classes and countries to fire. As expected, differences between northern and southern Europe are notorious in what concern to land cover distribution, fire incidence and fire proneness of vegetation cover classes. This work was supported by national funds by FCT - Portuguese Foundation for Science and Technology, under the project PEst-OE/AGR/UI4033/2014 and by the project SUSTAINSYS: Environmental Sustainable Agro-Forestry Systems (NORTE-07-0124-FEDER-000044), financed by the North Portugal Regional Operational Programme (ON.2 - O Novo Norte), under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER), as well as by National Funds (PIDDAC) through the Portuguese Foundation for Science and Technology (FCT/MEC).

Conservation status and regional habitat priorities for the Orinoco crocodile: Past, present, and future.

PubMed

Balaguera-Reina, Sergio A; Espinosa-Blanco, Ariel S; Morales-Betancourt, Mónica A; Seijas, Andrés E; Lasso, Carlos A; Antelo, Rafael; Densmore, Llewellyn D

2017-01-01

Conservation of large predator species has historically been a challenge because they often overlap in resource utilization with humans; furthermore, there is a general lack of in-depth knowledge of their ecology and natural history. We assessed the conservation status of the Orinoco crocodile (Crocodylus intermedius), defining regional habitat priorities/crocodile conservation units (RHP/CCU) and regional research priorities (RRP) for this species. We also estimated a species distribution model (SDM) to define current suitable areas where the species might inhabit and/or that might be successfully colonized. The SDM area obtained with a suitable habitat probability ≥ 0.5 was 23,621 km2. Out of 2,562 km2 are included within protected areas in both Colombia (1,643 km2) and Venezuela (919 km2), which represents only 10.8% of C. intermedius' potential range. Areas such as Laguna de Chigüichigüe (flood plain lagoon) exhibited an increase in population abundance. In contrast, localities such as the Cojedes and Manapire Rivers reported a significant reduction in relative abundance values. In Colombia, disparity in previous survey methods prevented accurate estimation of population trends. Only one study in this country described an increase over a 13 years span in the Ele, Lipa, and Cravo Norte River populations based on nest surveys. We defined 34 critical areas (16 in Colombia, 17 in Venezuela, and one covering both countries) where we need to preserve/research/monitor and/or generate management actions, 10 RHP/CCU (six from Venezuela and four from Colombia) and 24 RRP (11 from Venezuela, 12 from Colombia, and one in both countries). Caño Guaritico (Creek) and the Capanaparo River in Venezuela and the Ele, Lipa, Cravo Norte River System and the Guayabero River in Colombia were defined as areas with the most optimal conditions for long-term preservation and maintenance of C. intermedius populations. We conclude that the conservation status of this species is still critical, which implies the necessity to increase efforts to recover the species, especially in Colombia, to guarantee its survival as a structural and functional component of the ecosystems it inhabits.

Radiation Therapy and Cardiac Death in Long-Term Survivors of Esophageal Cancer: An Analysis of the Surveillance, Epidemiology, and End Result Database.

PubMed

Gharzai, Laila; Verma, Vivek; Denniston, Kyle A; Bhirud, Abhijeet R; Bennion, Nathan R; Lin, Chi

2016-01-01

Radiation therapy (RT) for esophageal cancer often results in unintended radiation doses delivered to the heart owing to anatomic proximity. Using the Surveillance, Epidemiology, and End Results (SEER) database, we examined late cardiac death in survivors of esophageal cancer that had or had not received RT. 5,630 patients were identified that were diagnosed with esophageal squamous cell carcinoma (SCC) or adenocarcinoma (AC) from 1973-2012, who were followed for at least 5 years after therapy. Examined risk factors for cardiac death included age (≤55/56-65/66-75/>75), gender, race (white/non-white), stage (local/regional/distant), histology (SCC/AC), esophageal location (<18cm/18-24cm/25-32cm/33-40cm from incisors), diagnosis year (1973-1992/1993-2002/2003-2012), and receipt of surgery and/or RT. Time to cardiac death was evaluated using the Kaplan-Meier method. A Cox model was used to evaluate risk factors for cardiac death in propensity score matched data. Patients who received RT were younger, diagnosed more recently, had more advanced disease, SCC histology, and no surgery. The RT group had higher risk of cardiac death than the no-RT group (log-rank p<0.0001). The median time to cardiac death in the RT group was 289 months (95% CI, 255-367) and was not reached in the no-RT group. The probability of cardiac death increased with age and decreased with diagnosis year, and this trend was more pronounced in the RT group. Multivariate analysis found RT to be associated with higher probability of cardiac death (OR 1.23, 95% CI 1.03-1.47, HR 1.961, 95% CI 1.466-2.624). Lower esophageal subsite (33-40 cm) was also associated with a higher risk of cardiac death. Other variables were not associated with cardiac death. Recognizing the limitations of a SEER analysis including lack of comorbidity accountability, these data should prompt more definitive study as to whether a possible associative effect of RT on cardiac death could potentially be a causative effect.

SU-C-204-02: Behavioral and Pathologic Differences in Mice Exposed to Proton Minibeam Arrays Versus Proton Broad Beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eley, J; Zhang, C; Wolfe, T

Purpose: Minibeam therapy using protons or light-ions offers a theoretical reduction of biologic damage to tissues upstream of a tumor compared to broad-beam therapy while providing equal tumor control. The purpose of this study was to investigate behavioral and pathologic differences in mice after exposure of healthy brain to proton minibeam arrays versus proton broad beams. Methods: Twenty-four C57BL/6J juvenile mice were divided into 5 study arms: sham irradiation (NoRT), broad-beam 10 Gy (BB10), minibeam 10Gy (MB10), broad-beam 30 Gy (BB30), and minibeam 30 Gy (MB30), approximate integral entrance doses. Circular beams of 100 MeV protons with 7-mm diameter weremore » delivered laterally through the brain, either as broad beams or as planar minibeam arrays having 300-micron beam width and 1-mm spacing on center. Mice were followed for 8 months using standard behavioral tests. Pathologic studies were carried out at 8 months after irradiation. Results: Peak entrance doses were 10.0, 23.8, 30.0, and 71.3 Gy for mice in BB10, MB10, BB30, and MB30, respectively. Despite the high single-fraction doses, no animals showed signs of radiation sickness or neurophysical impairment over the 8-month study duration. The Morris water maze alternate-starting-position trial showed significant evidence of better spatial learning for mice in MB10 versus BB10 (p=0.026), but other behavioral tests showed no significant differences. Glial fibrillary acidic protein stains showed gliosis in arms BB10, BB30, and MB30 but not in NoRT or MB10. A secondary finding was categorically higher epilation in broad-beam arms compared with their minibeam dose counterparts. Conclusion: Our findings indicate trends that, despite the higher peak doses, proton minibeam therapy can reduce radiation side effects in shallow tissue and brain compared to proton broadbeam therapy. As the behavioral findings were mixed, confirmation studies are needed with larger numbers of animals. AAPM Research Seed Funding Grant.« less

Fragmented coastal boundary layer induced by gap winds

NASA Astrophysics Data System (ADS)

Caldeira, Rui M. A.; Iglesias, Isabel; Sala, Iria; Vieira, Rui R.; Bastos, Luísa

2015-04-01

The oceanic impact of offshore-localized winds in the NW Iberian Peninsula was studied. Satellite and in situ observations showed the formation of plumes protruding offshore from the coast. To study the dynamics of such episodes tee Coupled-Ocean-Atmosphere-Wave- Sediment Transport Modeling System (COAWST) was used to reproduce the coastal conditions of the nortwestern Iberian Peninsula, allowing the concurrent representation of local winds, waves, currents, and rivers runoff. The use of coupled models is of outmost importance in order to accurately study the impact of the local winds on the coastal currents. The NW Iberian Peninsula has prominent capes, promontories and submarine canyons, which produce persistent hydrodynamic features. Thus far, the scientific literature shows that the western Iberian rivers produce a recurrent combined plume often denominated as the Western Iberian Buoyant Plume (WIBP) which increases the stratification of the water column and produces a vertical retention mechanism that keeps the biological material inshore. The WIBP extends northward along the coast (over the inner-shelf), and forms a front with the warmer and more saline surface (offshore) waters. However during episodes of strong offshore winds this coastal boundary layer is broken interrupting the WIBP. Coastal orography allows the formation of down-valley winds that produce coastal jets, promoting the offshore transport of pollutants, larvae and sediments. Acknowledgments: Acknowledgments: Numerical model solutions were calculated at CIIMARs HPC unit, acquired and maintained by FCT pluriannual funds (PesTC/Mar/LA0015/2013), and RAIA (0313-RAIA-1-E) and RAIA.co (0520-RAIACO-1-E) projects. The NICC (POCTI/CTA/49563/2002) project provided databases for this work. Rui Caldeira was supported by funds from the ECORISK project (NORTE-07-0124-FEDER-000054), co-financed by the North Portugal Regional Operational Programme (ON.2 - O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF). RAIA.co and RAIA tec (0688-RAIATEC-1-P) projects provided postdoctoral funds for Isabel Iglesias. The RAIA Coastal Observatory has been funded by the Programa Operativo de Cooperación Transfronteriza España-Portugal (POCTEP 2007-2013).

Retrospective Study of the Epidemiology and Clinical Manifestations of Cryptococcus gattii Infections in Colombia from 1997–2011

PubMed Central

Lizarazo, Jairo; Escandón, Patricia; Agudelo, Clara Inés; Firacative, Carolina; Meyer, Wieland; Castañeda, Elizabeth

2014-01-01

Background Cryptococcosis due to Cryptococcus gattii is endemic in various parts of the world, affecting mostly immunocompetent patients. A national surveillance study of cryptococcosis, including demographical, clinical and microbiological data, has been ongoing since 1997 in Colombia, to provide insights into the epidemiology of this mycosis. Methodology/Principal Findings From 1,209 surveys analyzed between 1997–2011, 45 cases caused by C. gattii were reported (prevalence 3.7%; annual incidence 0.07 cases/million inhabitants/year). Norte de Santander had the highest incidence (0.81 cases/million/year), representing 33.3% of all cases. The male: female ratio was 3.3∶1. Mean age at diagnosis was 41±16 years. No specific risk factors were identified in 91.1% of patients. HIV infection was reported in 6.7% of patients, autoimmune disease and steroids use in 2.2%. Clinical features included headache (80.5%), nausea/vomiting (56.1%) and neurological derangements (48.8%). Chest radiographs were taken in 21 (46.7%) cases, with abnormal findings in 7 (33.3%). Cranial CT scans were obtained in 15 (33.3%) cases, with abnormalities detected in 10 (66.7%). Treatment was well documented in 30 cases, with most receiving amphotericin B. Direct sample examination was positive in 97.7% cases. Antigen detection was positive for all CSF specimens and for 75% of serum samples. C. gattii was recovered from CSF (93.3%) and respiratory specimens (6.6%). Serotype was determined in 42 isolates; 36 isolates were serotype B (85.7%), while 6 were C (14.3%). The breakdowns of molecular types were VGII (55.6%), VGIII (31.1%) and VGI (13.3%). Among 44 strains, 16 MLST sequence types (ST) were identified, 11 of them newly reported. Conclusions/Significance The results of this passive surveillance study demonstrate that cryptococcosis caused by C. gattii has a low prevalence in Colombia, with the exception of Norte de Santander. The predominance of molecular type VGII is of concern considering its association with high virulence and the potential to evolve into outbreaks. PMID:25411779

A wood density and aboveground biomass variability assessment using pre-felling inventory data in Costa Rica.

PubMed

Svob, Sienna; Arroyo-Mora, J Pablo; Kalacska, Margaret

2014-12-01

The high spatio-temporal variability of aboveground biomass (AGB) in tropical forests is a large source of uncertainty in forest carbon stock estimation. Due to their spatial distribution and sampling intensity, pre-felling inventories are a potential source of ground level data that could help reduce this uncertainty at larger spatial scales. Further, exploring the factors known to influence tropical forest biomass, such as wood density and large tree density, will improve our knowledge of biomass distribution across tropical regions. Here, we evaluate (1) the variability of wood density and (2) the variability of AGB across five ecosystems of Costa Rica. Using forest management (pre-felling) inventories we found that, of the regions studied, Huetar Norte had the highest mean wood density of trees with a diameter at breast height (DBH) greater than or equal to 30 cm, 0.623 ± 0.182 g cm -3 (mean ± standard deviation). Although the greatest wood density was observed in Huetar Norte, the highest mean estimated AGB (EAGB) of trees with a DBH greater than or equal to 30 cm was observed in Osa peninsula (173.47 ± 60.23 Mg ha -1 ). The density of large trees explained approximately 50% of EAGB variability across the five ecosystems studied. Comparing our study's EAGB to published estimates reveals that, in the regions of Costa Rica where AGB has been previously sampled, our forest management data produced similar values. This study presents the most spatially rich analysis of ground level AGB data in Costa Rica to date. Using forest management data, we found that EAGB within and among five Costa Rican ecosystems is highly variable. Combining commercial logging inventories with ecological plots will provide a more representative ground level dataset for the calibration of the models and remotely sensed data used to EAGB at regional and national scales. Additionally, because the non-protected areas of the tropics offer the greatest opportunity to reduce rates of deforestation and forest degradation, logging inventories offer a promising source of data to support mechanisms such as the United Nations REDD + (Reducing Emissions from Tropical Deforestation and Degradation) program.

Conservation status and regional habitat priorities for the Orinoco crocodile: Past, present, and future

PubMed Central

Espinosa-Blanco, Ariel S.; Morales-Betancourt, Mónica A.; Seijas, Andrés E.; Lasso, Carlos A.; Antelo, Rafael; Densmore, Llewellyn D.

2017-01-01

Conservation of large predator species has historically been a challenge because they often overlap in resource utilization with humans; furthermore, there is a general lack of in-depth knowledge of their ecology and natural history. We assessed the conservation status of the Orinoco crocodile (Crocodylus intermedius), defining regional habitat priorities/crocodile conservation units (RHP/CCU) and regional research priorities (RRP) for this species. We also estimated a species distribution model (SDM) to define current suitable areas where the species might inhabit and/or that might be successfully colonized. The SDM area obtained with a suitable habitat probability ≥ 0.5 was 23,621 km2. Out of 2,562 km2 are included within protected areas in both Colombia (1,643 km2) and Venezuela (919 km2), which represents only 10.8% of C. intermedius’ potential range. Areas such as Laguna de Chigüichigüe (flood plain lagoon) exhibited an increase in population abundance. In contrast, localities such as the Cojedes and Manapire Rivers reported a significant reduction in relative abundance values. In Colombia, disparity in previous survey methods prevented accurate estimation of population trends. Only one study in this country described an increase over a 13 years span in the Ele, Lipa, and Cravo Norte River populations based on nest surveys. We defined 34 critical areas (16 in Colombia, 17 in Venezuela, and one covering both countries) where we need to preserve/research/monitor and/or generate management actions, 10 RHP/CCU (six from Venezuela and four from Colombia) and 24 RRP (11 from Venezuela, 12 from Colombia, and one in both countries). Caño Guaritico (Creek) and the Capanaparo River in Venezuela and the Ele, Lipa, Cravo Norte River System and the Guayabero River in Colombia were defined as areas with the most optimal conditions for long-term preservation and maintenance of C. intermedius populations. We conclude that the conservation status of this species is still critical, which implies the necessity to increase efforts to recover the species, especially in Colombia, to guarantee its survival as a structural and functional component of the ecosystems it inhabits. PMID:28234956

Primer registro para Peru del genero Nielsonia Young, 1977 (Hemiptera: Cicadellidae: Cicadellinae: Cicadellini)

USDA-ARS?s Scientific Manuscript database

En este articulo se reporta por primera vez para el Peru una especies del genero Nielsonia Young, 1977, de material procedente del Departamento de Tumbes. El genero ha sido reportada anteriormente de Ecuador, como unico registro para Sudamerica, y America Central. El unico especimen hembra encontra...

33 CFR 110.65 - Indian River Bay, Del.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Indian River Bay, Del. 110.65 Section 110.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing...

Pastoral del Nino: Bringing the Abundant Life to Paraguayan Children

ERIC Educational Resources Information Center

Austin, Ann Berghout; Aquino, Cyle; Burro, Elizabeth

2007-01-01

Pastoral del Nino is transforming children's lives in rural Paraguay. Part of Pastoral Social (Catholic Social Services), Pastoral del Nino's primary focus is to bring "vida en abundancia" (the abundant life) to families by ensuring that mothers survive childbirth and children reach their first birthdays. In addition, the organization…

Calidad del aire interior en las escuelas

EPA Pesticide Factsheets

EPA ha desarrollado el Programa de Herramientas de Calidad del Aire Interior para las Escuelas para reducir la exposición a los contaminantes ambientales en las mismas a través de la adopción voluntaria de las prácticas para manejar la calidad del aire int

The Armed Forces and the Fight against Drug-Trafficking in Honduras (Las FUERZAS ARMADAS EN EL COMBATE AL NARCOTR FICO EN HONDURAS)

DTIC Science & Technology

2013-06-13

Estado Mayor del Ejército de EE. UU. En cumplimiento parcial de los requisitos para la obtención del grado de MAESTRÍA EN CIENCIAS Y ARTES MILITARES...Estudios Generales Por WALTER D. HERNANDEZ CARVAJAL, MAYOR DEL EJÉRCITO DE HONDURAS Licenciado en Ciencias Militares...Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39.18 ii MAESTRÍA EN ARTES Y CIENCIAS MILITARES PÁGINA DE APROBACIÓN DE LA TESIS Nombre del

Resultados del relevamiento de HI en el Cielo Austral: 3. Relevamiento de Nubes de Alta Velocidad

NASA Astrophysics Data System (ADS)

Morras, R.; Bajaja, E.; Arnal, E. M.; Pöppel, W. G. L.

Los resultados del relevamiento de HI del Hemisferio Austral fueron reprocesados con el fin de incrementar su sensibilidad. Así, se utilizó esta nueva base de datos con el fin de obtener un nuevo relevamiento de Nubes de Alta Velocidad en el cielo austral. El ruido r.m.s. alcanzado es de 0.015-0.020 K, con una resolución espectral de 8 km/seg. El cubrimiento espacial del relevamiento mejora en un factor 16 al realizado por Bajaja et al (1985).

Multi-InDel Analysis for Ancestry Inference of Sub-Populations in China

PubMed Central

Sun, Kuan; Ye, Yi; Luo, Tao; Hou, Yiping

2016-01-01

Ancestry inference is of great interest in diverse areas of scientific researches, including the forensic biology, medical genetics and anthropology. Various methods have been published for distinguishing populations. However, few reports refer to sub-populations (like ethnic groups) within Asian populations for the limitation of markers. Several InDel loci located very tightly in physical positions were treated as one marker by us, which is multi-InDel. The multi-InDel shows potential as Ancestry Inference Marker (AIM). In this study, we performed a genome-wide scan for multi-InDels as AIM. After examining the FST distributions in the 1000 Genomes Database, 12 candidates were selected and validated for eastern Asian populations. A multiplexed assay was developed as a panel to genotype 12 multi-InDel markers simultaneously. Ancestry component analysis with STRUCTURE and principal component analysis (PCA) were employed to estimate its capability for ancestry inference. Furthermore, ancestry assignments of trial individuals were conducted. It proved to be very effective when 210 samples from Han and Tibetan individuals in China were tested. The panel consisting of multi-InDel markers exhibited considerable potency in ancestry inference, and was suggested to be applied in forensic practices and genetic population studies. PMID:28004788

Delayed fertilization of anuran amphibian (Xenopus) eggs leads to reduced numbers of primordial germ cells

NASA Technical Reports Server (NTRS)

Wakahara, M.; Neff, A. W.; Malacinski, G. M.

1984-01-01

Several media were tested for the extent to which they promoted high fertilization efficiencies in ovulated, stripped Xenopus eggs. One medium was selected for maintaining eggs in a 'delayed fertilization' (DelF) condition. DelF eggs displayed several unusual characteristics, including shift of the center of gravity, prominent sperm entrance site, and occasional polyspermy. The frequency of normal pattern formation varied according to the length of time eggs were maintained in the DelF condition. Various developmental abnormalities were observed during gastrulation, neurulation, and organogenesis. Most abnormalities appeared, however, to be related to morphogenesis of the endoderm. Primordial germ cell (PGC) development was examined in DelF eggs which displayed normal external morphological features at the swimming tadpole stage. PGC counts were usually normal in short-duration (eg, 5 hr) DelF eggs, but frequently substantially reduced or completely diminished in longer-duration (eg, 25h) tadpoles. Six spawnings were compared and shown to exhibit considerable variability in fertility, morphogenesis, and PGC development. Yolk platelet shifts and developmental parameters were examined in two additional spawnings. The subcortical cytoplasm in which the germ plasm is normally localized appeared to be disrupted in longer duration DelF eggs. That observation may account for low PGC counts in DelF tadpoles.

Nonmutagenic carcinogens induce intrachromosomal recombination in dividing yeast cells.

PubMed

Schiestl, R H

1993-12-01

A large number of animal and human carcinogens without apparent genotoxic activity exist (nonmutagenic carcinogens) that are difficult or impossible to detect with the currently used short-term tests. Because of the association of carcinogenesis with genome rearrangement, a system selecting for intrachromosomal recombination (DEL recombination) that results in genome rearrangement has been constructed in the yeast Saccharomyces cerevisiae. Because DEL recombination is under different genetic control than interchromosomal recombination and meiotic recombination, it is probably due to a different mechanism. It has been found that DEL recombination is readily inducible by 10 mutagenic carcinogens and 17 nonmutagenic carcinogens that are not detectable (false negatives) with the Ames assay. In addition, three out of four mutagens that do not cause cancer (false positives in the Ames assay) do not induce DEL recombination. DEL recombination is inducible by UV only in dividing cells but not in cells synchronized in the G1 or G2 phase of the cell cycle. Interchromosomal recombination, on the other hand, is inducible in G1 but not in G2. The nonmutagenic carcinogens induce DEL recombination only in actively growing cells, which may give some indication as to their mechanism. Further characterization of the mechanism involved in induction of DEL recombination may contribute to the understanding of the biological activity of nonmutagenic carcinogens.

Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage.

PubMed

Li, Juan; Prins, Daniel; Park, Hyun Jung; Grinfeld, Jacob; Gonzalez-Arias, Carlos; Loughran, Stephen; Dovey, Oliver M; Klampfl, Thorsten; Bennett, Cavan; Hamilton, Tina L; Pask, Dean C; Sneade, Rachel; Williams, Matthew; Aungier, Juliet; Ghevaert, Cedric; Vassiliou, George S; Kent, David G; Green, Anthony R

2018-02-08

Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). Multiple different mutations have been reported, but all result in a +1-bp frameshift and generate a novel protein C terminus. In this study, we generated a conditional mouse knockin model of the most common CALR mutation, a 52-bp deletion. The mutant novel human C-terminal sequence is integrated into the otherwise intact mouse CALR gene and results in mutant CALR expression under the control of the endogenous mouse locus. CALR del/+ mice develop a transplantable ET-like disease with marked thrombocytosis, which is associated with increased and morphologically abnormal megakaryocytes and increased numbers of phenotypically defined hematopoietic stem cells (HSCs). Homozygous CALR del/del mice developed extreme thrombocytosis accompanied by features of MF, including leukocytosis, reduced hematocrit, splenomegaly, and increased bone marrow reticulin. CALR del/+ HSCs were more proliferative in vitro, but neither CALR del/+ nor CALR del/del displayed a competitive transplantation advantage in primary or secondary recipient mice. These results demonstrate the consequences of heterozygous and homozygous CALR mutations and provide a powerful model for dissecting the pathogenesis of CALR-mutant ET and PMF. © 2018 by The American Society of Hematology.

Evaluación de la utilidad diagnóstica de la versión española del cuestionario al informador «AD8»☆

PubMed Central

Pardo, C. Carnero; de la Vega Cotarelo, R.; Alcalde, S. López; Aparicio, C. Martos; Carrillo, R. Vílchez; Gavilán, E. Mora; Galvin, J.E.

2012-01-01

Introducción El AD8 es un cuestionario al informador breve que puede ser autoaplicado y facilita la identificación de deterioro cognitivo (DC); nuestro objetivo es evaluar la utilidad diagnóstica (UD) de una versión española. Material y métodos Estudio transversal en una muestra clínica de díadas paciente/ informador, 330 sujetos con sospecha de DC o demencia (DEM) y 71 controles. Se ha evaluado la consistencia interna (α de Cronbach) y la validez (correlaciones parciales con estadio GDS, Fototest e índice funcional [IF]). La UD se ha evaluado para no DC vs DC (GDS 3–4) por medio del área bajo la curva ROC (aROC) y se ha considerado mejor punto de corte aquel que hacía máximo el índice de Youden. Resultados En la muestra, 105 no tenían DC, 99 tenían DC sin DEM y 203 DEM. La consistencia interna es alta (α 0,90, IC del 95%, 0,89–0,92), al igual que las correlaciones con GDS (r = 0,72, p < 0,001), Fototest (r = −0,61, p < 0,001) e IF (r = 0,59, p < 0,001). El aROC del AD8 es 0,90 (IC del 95%, 0,86–0,93), sin diferencia significativa con la del Fototest (aROC 0,93, IC del 95%, 0,89–0,96); el mejor punto de corte es 3/4 con sensibilidad de 0,93 (IC del 95%, 0,88–0,96), especificidad de 0,81 (IC del 95%, 0,72–0,88) y el 88,8% de las clasificaciones correctas. El uso conjunto de AD8 y Fototest mejora de forma significativa la UD de ambos (aROC 0,96, IC del 95%, 0,93–0,98, p < 0,05). Conclusiones La versión española del AD8 conserva las cualidades psicométricas y la UD de la versión original; su uso combinado con el Fototest mejora de forma significativa la UD de ambos. PMID:22652137

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1

PubMed Central

Ren, Hong Yu; Grove, Diane E.; De La Rosa, Oxana; Houck, Scott A.; Sopha, Pattarawut; Van Goor, Fredrick; Hoffman, Beth J.; Cyr, Douglas M.

2013-01-01

Cystic fibrosis (CF) is a fatal genetic disorder associated with defective hydration of lung airways due to the loss of chloride transport through the CF transmembrane conductance regulator protein (CFTR). CFTR contains two membrane-spanning domains (MSDs), two nucleotide-binding domains (NBDs), and a regulatory domain, and its channel assembly requires multiple interdomain contacts. The most common CF-causing mutation, F508del, occurs in NBD1 and results in misfolding and premature degradation of F508del-CFTR. VX-809 is an investigational CFTR corrector that partially restores CFTR function in people who are homozygous for F508del-CFTR. To identify the folding defect(s) in F508del-CFTR that must be repaired to treat CF, we explored the mechanism of VX-809 action. VX-809 stabilized an N-terminal domain in CFTR that contains only MSD1 and efficaciously restored function to CFTR forms that have missense mutations in MSD1. The action of VX-809 on MSD1 appears to suppress folding defects in F508del-CFTR by enhancing interactions among the NBD1, MSD1, and MSD2 domains. The ability of VX-809 to correct F508del-CFTR is enhanced when combined with mutations that improve F508del-NBD1 interaction with MSD2. These data suggest that the use of VX-809 in combination with an additional CFTR corrector that suppresses folding defects downstream of MSD1 may further enhance CFTR function in people with F508del-CFTR. PMID:23924900

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.

PubMed

Ren, Hong Yu; Grove, Diane E; De La Rosa, Oxana; Houck, Scott A; Sopha, Pattarawut; Van Goor, Fredrick; Hoffman, Beth J; Cyr, Douglas M

2013-10-01

Cystic fibrosis (CF) is a fatal genetic disorder associated with defective hydration of lung airways due to the loss of chloride transport through the CF transmembrane conductance regulator protein (CFTR). CFTR contains two membrane-spanning domains (MSDs), two nucleotide-binding domains (NBDs), and a regulatory domain, and its channel assembly requires multiple interdomain contacts. The most common CF-causing mutation, F508del, occurs in NBD1 and results in misfolding and premature degradation of F508del-CFTR. VX-809 is an investigational CFTR corrector that partially restores CFTR function in people who are homozygous for F508del-CFTR. To identify the folding defect(s) in F508del-CFTR that must be repaired to treat CF, we explored the mechanism of VX-809 action. VX-809 stabilized an N-terminal domain in CFTR that contains only MSD1 and efficaciously restored function to CFTR forms that have missense mutations in MSD1. The action of VX-809 on MSD1 appears to suppress folding defects in F508del-CFTR by enhancing interactions among the NBD1, MSD1, and MSD2 domains. The ability of VX-809 to correct F508del-CFTR is enhanced when combined with mutations that improve F508del-NBD1 interaction with MSD2. These data suggest that the use of VX-809 in combination with an additional CFTR corrector that suppresses folding defects downstream of MSD1 may further enhance CFTR function in people with F508del-CFTR.

Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis.

PubMed

Esposito, Speranza; Tosco, Antonella; Villella, Valeria R; Raia, Valeria; Kroemer, Guido; Maiuri, Luigi

2016-12-01

Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concentrations, progressive lung disease with chronic inflammation and recurrent bacterial infections, pancreatic insufficiency, and male infertility. Therapies aimed at restoring the CFTR defect have emerged. Thus, a small molecule which facilitates chloride channel opening, the potentiator Ivacaftor, has been approved for the treatment of CF patients bearing a particular class of rare CFTR mutations. However, small molecules that directly target the most common misfolded CFTR mutant, F508del, and improve its intracellular trafficking in vitro, have been less effective than expected when tested in CF patients, even in combination with Ivacaftor. Thus, new strategies are required to circumvent the F508del-CFTR defect. Airway and intestinal epithelial cells from CF patients bearing the F508del-CFTR mutation exhibit an impressive derangement of cellular proteostasis, with oxidative stress, overactivation of the tissue transglutaminase (TG2), and disabled autophagy. Proteostasis regulators such as cysteamine can rescue and stabilize a functional F508del-CFTR protein through suppressing TG2 activation and restoring autophagy in vivo in F508del-CFTR homozygous mice, in vitro in CF patient-derived cell lines, ex vivo in freshly collected primary patient's nasal cells, as well as in a pilot clinical trial involving homozygous F508del-CFTR patients. Here, we discuss how the therapeutic normalization of defective proteostasis can be harnessed for the treatment of CF patients with the F508del-CFTR mutation.

Genetic modifiers of CHEK2*1100delC associated breast cancer risk

PubMed Central

Muranen, Taru A.; Greco, Dario; Blomqvist, Carl; Aittomäki, Kristiina; Khan, Sofia; Hogervorst, Frans; Verhoef, Senno; Pharoah, Paul D.P.; Dunning, Alison M.; Shah, Mitul; Luben, Robert; Bojesen, Stig E.; Nordestgaard, Børge G.; Schoemaker, Minouk; Swerdlow, Anthony; García-Closas, Montserrat; Figueroa, Jonine; Dörk, Thilo; Bogdanova, Natalia V.; Hall, Per; Li, Jingmei; Khusnutdinova, Elza; Bermisheva, Marina; Kristensen, Vessela; Borresen-Dale, Anne-Lise; Peto, Julian; dos Santos Silva, Isabel; Couch, Fergus J.; Olson, Janet E.; Hillemans, Peter; Park-Simon, Tjoung-Won; Brauch, Hiltrud; Hamann, Ute; Burwinkel, Barbara; Marme, Frederik; Meindl, Alfons; Schmutzler, Rita K.; Cox, Angela; Cross, Simon S.; Sawyer, Elinor J.; Tomlinson, Ian; Lambrechts, Diether; Moisse, Matthieu; Lindblom, Annika; Margolin, Sara; Hollestelle, Antoinette; Martens, John W.M.; Fasching, Peter A.; Beckmann, Matthias W.; Andrulis, Irene L.; Knight, Julia A.; Anton-Culver, Hoda; Ziogas, Argyrios; Giles, Graham G.; Milne, Roger L.; Brenner, Hermann; Arndt, Volker; Mannermaa, Arto; Kosma, Veli-Matti; Chang-Claude, Jenny; Rudolph, Anja; Devilee, Peter; Seynaeve, Caroline; Hopper, John L.; Southey, Melissa C.; John, Esther M.; Whittemore, Alice S.; Bolla, Manjeet K.; Wang, Qin; Michailidou, Kyriaki; Dennis, Joe; Easton, Douglas F.; Schmidt, Marjanka K.; Nevanlinna, Heli

2016-01-01

Purpose CHEK2*1100delC is a founder variant in European populations conferring a 2–3 fold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with CHEK2*1100delC is modified by other genetic factors in a multiplicative fashion. We have investigated this empirically using data from the Breast Cancer Association Consortium (BCAC). Methods With genotype data of 39,139 (624 1100delC carriers) BC patients and 40,063 (224) healthy controls from 32 BCAC studies, we analyzed the combined risk effects of CHEK2*1100delC and 77 common variants in terms of a polygenic risk score (PRS) and pairwise interaction. Results The PRS conferred an odds ratio (OR) of 1.59 [95% CI 1.21–2.09] per standard deviation for BC for CHEK2*1100delC carriers and 1.58 [1.55–1.62] for non-carriers. No evidence for deviation from the multiplicative model was found. The OR for the highest quintile of the PRS was 2.03 [0.86–4.78] for CHEK2*1100delC carriers placing them to the high risk category according to UK NICE guidelines. OR for the lowest quintile was 0.52 [0.16–1.74], indicating life-time risk close to population average. Conclusion Our results confirm the multiplicative nature of risk effects conferred by CHEK2*1100delC and the common susceptibility variants. Furthermore, the PRS could identify the carriers at a high life-time risk for clinical actions. PMID:27711073

Genetic modifiers of CHEK2*1100delC-associated breast cancer risk.

PubMed

Muranen, Taru A; Greco, Dario; Blomqvist, Carl; Aittomäki, Kristiina; Khan, Sofia; Hogervorst, Frans; Verhoef, Senno; Pharoah, Paul D P; Dunning, Alison M; Shah, Mitul; Luben, Robert; Bojesen, Stig E; Nordestgaard, Børge G; Schoemaker, Minouk; Swerdlow, Anthony; García-Closas, Montserrat; Figueroa, Jonine; Dörk, Thilo; Bogdanova, Natalia V; Hall, Per; Li, Jingmei; Khusnutdinova, Elza; Bermisheva, Marina; Kristensen, Vessela; Borresen-Dale, Anne-Lise; Investigators, Nbcs; Peto, Julian; Dos Santos Silva, Isabel; Couch, Fergus J; Olson, Janet E; Hillemans, Peter; Park-Simon, Tjoung-Won; Brauch, Hiltrud; Hamann, Ute; Burwinkel, Barbara; Marme, Frederik; Meindl, Alfons; Schmutzler, Rita K; Cox, Angela; Cross, Simon S; Sawyer, Elinor J; Tomlinson, Ian; Lambrechts, Diether; Moisse, Matthieu; Lindblom, Annika; Margolin, Sara; Hollestelle, Antoinette; Martens, John W M; Fasching, Peter A; Beckmann, Matthias W; Andrulis, Irene L; Knight, Julia A; Investigators, kConFab/Aocs; Anton-Culver, Hoda; Ziogas, Argyrios; Giles, Graham G; Milne, Roger L; Brenner, Hermann; Arndt, Volker; Mannermaa, Arto; Kosma, Veli-Matti; Chang-Claude, Jenny; Rudolph, Anja; Devilee, Peter; Seynaeve, Caroline; Hopper, John L; Southey, Melissa C; John, Esther M; Whittemore, Alice S; Bolla, Manjeet K; Wang, Qin; Michailidou, Kyriaki; Dennis, Joe; Easton, Douglas F; Schmidt, Marjanka K; Nevanlinna, Heli

2017-05-01

CHEK2*1100delC is a founder variant in European populations that confers a two- to threefold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with CHEK2*1100delC is modified by other genetic factors in a multiplicative fashion. We have investigated this empirically using data from the Breast Cancer Association Consortium (BCAC). Using genotype data from 39,139 (624 1100delC carriers) BC patients and 40,063 (224) healthy controls from 32 BCAC studies, we analyzed the combined risk effects of CHEK2*1100delC and 77 common variants in terms of a polygenic risk score (PRS) and pairwise interaction. The PRS conferred odds ratios (OR) of 1.59 (95% CI: 1.21-2.09) per standard deviation for BC for CHEK2*1100delC carriers and 1.58 (1.55-1.62) for noncarriers. No evidence of deviation from the multiplicative model was found. The OR for the highest quintile of the PRS was 2.03 (0.86-4.78) for CHEK2*1100delC carriers, placing them in the high risk category according to UK NICE guidelines. The OR for the lowest quintile was 0.52 (0.16-1.74), indicating a lifetime risk close to the population average. Our results confirm the multiplicative nature of risk effects conferred by CHEK2*1100delC and the common susceptibility variants. Furthermore, the PRS could identify carriers at a high lifetime risk for clinical actions.Genet Med advance online publication 06 October 2016.

33 CFR 110.65 - Indian River Bay, Del.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Indian River Bay, Del. 110.65... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing... State highway bridge across Indian River Inlet; thence 174°, 600 feet; thence 264°, 800 feet; thence 354...

33 CFR 110.65 - Indian River Bay, Del.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Indian River Bay, Del. 110.65... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing... State highway bridge across Indian River Inlet; thence 174°, 600 feet; thence 264°, 800 feet; thence 354...

33 CFR 110.65 - Indian River Bay, Del.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Indian River Bay, Del. 110.65... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing... State highway bridge across Indian River Inlet; thence 174°, 600 feet; thence 264°, 800 feet; thence 354...

33 CFR 110.65 - Indian River Bay, Del.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Indian River Bay, Del. 110.65... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing... State highway bridge across Indian River Inlet; thence 174°, 600 feet; thence 264°, 800 feet; thence 354...

Analisis espacial de las areas protegidas terrestres de Puerto Rico

Treesearch

M. Quinones; W.A. Gould; J. Castro-Prieto; S. Martinuzzi

2013-01-01

En este mapa de investigacion describimos las areas protegidas terrestres de Puerto Rico basado en elementos naturales y antropogenicos del paisaje. Utilizamos datos geoespaciales para calcular la extension y representatividad de elementos del paisaje dentro de las areas protegidas de Puerto Rico, i.e., cobertura del terreno (Gould et al. 2007), asentamientos urbanos...

Defense.gov - Dignity, Honor, Respect - For the Fallen

Science.gov Websites

combat operation passes through Dover Air Force Base, Del. The responsibility, and honor, of preparing Operations Center. Stories Dignified Transfer Pays Tribute to Fallen DOVER AIR FORCE BASE, Del., March 12 vehicle to the Air Force Mortuary Affairs Operations Center at Dover Air Force Base, Del. Story Center

Ecuadorean-Peruvian Rivalry in the Upper Amazon,

DTIC Science & Technology

1978-01-01

8217 y el Ecuador. Documentos anexos a la Memoria del Per. Madrid, 1903. Vol. III, Document 86- p. 216 ff. 2. Jorge W. Villacres Moscoso, Historia...AMISTAD Y LIMITES ENTRE PERU Y ECUADOR Los Gobiernos del Peru’ y del Ecuador, deseando dar solucior. a la cuestic~n de Ifmites que por largo tiempo los

Ácaros del mango

USDA-ARS?s Scientific Manuscript database

Los ácaros constituyen un grupo abundante y diverso que ocupa diferentes hábitats en árboles frutales y la estructura y disposición del follaje y ramas del mango, contribuyen significativamente a que se presente gran diversidad de ácaros benéficos y dañinos asociados a esta especie frutal. En Colomb...

33 CFR 334.110 - Delaware Bay off Cape Henlopen, Del.; naval restricted area.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Del.; naval restricted area. 334.110 Section 334.110 Navigation and Navigable Waters CORPS OF....110 Delaware Bay off Cape Henlopen, Del.; naval restricted area. (a) The area. Beginning at a point on... regulations in this section shall be enforced by the Commandant, Fourth Naval District, and such agencies as...

[Recommendations to improve the scientific communication process in the Revista Médica del IMSS].

PubMed

Álvarez, Ivón

2016-01-01

In order to improve the position of the Revista Médica del Instituto Mexicano del Seguro Social among the different journals, in this editorial we enumerate a series of recommendations to ameliorate the practices of the different actors who participate in the scientific communication process of this journal.

Modeling landscapes and past vegetation patterns of New Mexico's Rio Del Oso Valley

Treesearch

Richard D. Periman

2005-01-01

Humans have interacted with the landscape and ecosystem of New Mexico's Rio del Oso Valley for thousands of years. Throughout the Holocene, various cultures have dramatically affected and altered the Rio del Oso. An interdisciplinary research approach, incorporating geomorphology, paleobotany, archaeology, and history, provides a broad range of methodologies and...

Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.

PubMed

Chandran, Divya; Rickert, Joshua; Huang, Yingxiang; Steinwand, Michael A; Marr, Sharon K; Wildermuth, Mary C

2014-04-09

In plants, the activation of immunity is often inversely correlated with growth. Mechanisms that control plant growth in the context of pathogen challenge and immunity are unclear. Investigating Arabidopsis infection with the powdery mildew fungus, we find that the Arabidopsis atypical E2F DEL1, a transcriptional repressor known to promote cell proliferation, represses accumulation of the hormone salicylic acid (SA), an established regulator of plant immunity. DEL1-deficient plants are more resistant to pathogens and slightly smaller than wild-type. The resistance and size phenotypes of DEL1-deficient plants are due to the induction of SA and activation of immunity in the absence of pathogen challenge. Moreover, Enhanced Disease Susceptibility 5 (EDS5), a SA transporter required for elevated SA and immunity, is a direct repressed target of DEL1. Together, these findings indicate that DEL1 control of SA levels contributes to regulating the balance between growth and immunity in developing leaves. Copyright © 2014 Elsevier Inc. All rights reserved.

[La diagnosi del disturbo da uso di alcol dal punto di vista psicologico].

PubMed

Coriale, Giovanna; Fiorentino, Daniela; Porrari, Raffaella; Battagliese, Gemma; Capriglione, Ida; Cereatti, Federica; Iannuzzi, Silvia; Mauri, Benilde; Galli, Domenica; Fiore, Marco; Attilia, Maria Luisa; Ceccanti, Mauro

2018-01-01

RIASSUNTO. Il disturbo da uso di alcol (DUA) è uno dei disturbi psichiatrici più comuni nella popolazione generale. Il DUA è caratterizzato da un pattern di bere eccessivo, che si mantiene nonostante gli effetti negativi che l'alcol ha sul funzionamento lavorativo, sulla salute, sulle problematiche legali, sull'educazione e sulla vita sociale. Attualmente, il modello bio-psico-sociale è quello che spiega meglio il DUA. Infatti, molte ricerche hanno fornito evidenze su come il DUA sia una patologia multidimensionale. Variabili biologiche, psicologiche e socio-culturali entrano in gioco nell'eziologia, nella natura, nel mantenimento e nel cambiamento nel tempo del disturbo. La fase diagnostica è un momento importante del processo di cura, perché il successo del trattamento dipende in larga misura dall'esattezza e dall'adeguatezza della diagnosi. La diagnosi clinica si basa su una valutazione globale del funzionamento del paziente e utilizza il colloquio e gli strumenti psicometrici come mezzo di raccolta di informazioni. Questo articolo fornirà una panoramica delle dimensioni psicologiche più importanti da valutare e sui migliori strumenti psicometrici da usare per una diagnosi adeguata.

Medición de densidades medias de meteoritos: test del método de inmersión

NASA Astrophysics Data System (ADS)

Steren, G.

Se evaluó una técnica simple para medir las densidades medias de meteoritos, basada en el Método de Arquímedes y que utiliza cuentas de vidrio de 40μ en lugar de un fluído esto presenta la ventaja de no ser intrusivo ni químicamente reactivo (D.Britt and G.Consolmagno, 1996, B.A.A.S.28,1106). El estudio, realizado en junio de este año por participantes de la VI Escuela de Verano del Observatorio del Vaticano, empleó 37 muestras de la colección del Observatorio del Vaticano, de las cuales 26 eran Condritas, 1 Pallasita y 1 Howardita; algunas de ellas ya habian sido estudiadas por otras técnicas aunque también se incluyeron muestras no estudiadas anteriormente.

[Not Available].

PubMed

Chivu, Elena Cristina; Artero-Fullana, Ana; Alfonso García, Antonio; Sánchez Juan, Carlos

2016-07-19

Introducción: conociendo la elevada prevalencia de la desnutrición hospitalaria, se hace necesaria su detección precoz. Cuando, por diversos motivos, no es posible realizar una valoración completa del estado nutricional, se recomienda el empleo de herramientas validadas de cribado nutricional. Estas ayudarían a detectar de forma rápida a aquellos pacientes que necesiten de un tratamiento nutricional.Objetivos: determinar la prevalencia del riesgo de desnutrición, en el Hospital General Universitario de Valencia, empleando para ello la herramienta de cribado nutricional HEMAN y comprobar si la implementación de esta herramienta en la práctica clínica, sería lo más adecuado.Métodos: estudio transversal, realizado sobre una muestra de 1.099 pacientes ingresados en un hospital terciario. A todos ellos se les realizó el cribado nutricional HEMAN a las 24-48 horas del ingreso. Las variables cualitativas se compararon mediante Chi-cuadrado, y las cuantitativas mediante el test t de Student.Resultados: la prevalencia del riesgo de desnutrición fue del 33,5%. Los pacientes que resultaron positivos en el cribado (HEMAN ≥ 3), tenían mayor edad que los pacientes normonutridos, referían pérdidas de peso entre el 5-10%, el 55,2% disminuyó su ingesta a menos del 50% de la habitual. Además, ingresaron con patologías consideradas de leves a moderadas. La utilización del método HEMAN como herramienta de cribado, resultó ser práctica y efectiva, y ayudó a disminuir el tiempo empleado con cada paciente encuestado evaluado.Conclusiones: se detectó una elevada prevalencia de riesgo de desnutrición entre los pacientes evaluados, por lo tanto se hace imprescindible la utilización de métodos de cribado nutricional en la rutina diaria del hospital, para ello recomendamos especialmente la utilización del método HEMAN.

Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770

PubMed Central

Gentzsch, Martina; Ren, Hong Y.; Houck, Scott A.; Quinney, Nancy L.; Cholon, Deborah M.; Sopha, Pattarawut; Chaudhry, Imron G.; Das, Jhuma; Dokholyan, Nikolay V.; Randell, Scott H.

2016-01-01

Cystic fibrosis (CF) is a lethal recessive genetic disease caused primarily by the F508del mutation in the CF transmembrane conductance regulator (CFTR). The potentiator VX-770 was the first CFTR modulator approved by the FDA for treatment of CF patients with the gating mutation G551D. Orkambi is a drug containing VX-770 and corrector VX809 and is approved for treatment of CF patients homozygous for F508del, which has folding and gating defects. At least 30% of CF patients are heterozygous for the F508del mutation with the other allele encoding for one of many different rare CFTR mutations. Treatment of heterozygous F508del patients with VX-809 and VX-770 has had limited success, so it is important to identify heterozygous patients that respond to CFTR modulator therapy. R117H is a more prevalent rare mutation found in over 2,000 CF patients. In this study we investigated the effectiveness of VX-809/VX-770 therapy on restoring CFTR function in human bronchial epithelial (HBE) cells from R117H/F508del CF patients. We found that VX-809 stimulated more CFTR activity in R117H/F508del HBEs than in F508del/F508del HBEs. R117H expressed exclusively in immortalized HBEs exhibited a folding defect, was retained in the ER, and degraded prematurely. VX-809 corrected the R117H folding defect and restored channel function. Because R117 is involved in ion conductance, VX-770 acted additively with VX-809 to restore CFTR function in chronically treated R117H/F508del cells. Although treatment of R117H patients with VX-770 has been approved, our studies indicate that Orkambi may be more beneficial for rescue of CFTR function in these patients. PMID:27402691

Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770.

PubMed

Gentzsch, Martina; Ren, Hong Y; Houck, Scott A; Quinney, Nancy L; Cholon, Deborah M; Sopha, Pattarawut; Chaudhry, Imron G; Das, Jhuma; Dokholyan, Nikolay V; Randell, Scott H; Cyr, Douglas M

2016-09-01

Cystic fibrosis (CF) is a lethal recessive genetic disease caused primarily by the F508del mutation in the CF transmembrane conductance regulator (CFTR). The potentiator VX-770 was the first CFTR modulator approved by the FDA for treatment of CF patients with the gating mutation G551D. Orkambi is a drug containing VX-770 and corrector VX809 and is approved for treatment of CF patients homozygous for F508del, which has folding and gating defects. At least 30% of CF patients are heterozygous for the F508del mutation with the other allele encoding for one of many different rare CFTR mutations. Treatment of heterozygous F508del patients with VX-809 and VX-770 has had limited success, so it is important to identify heterozygous patients that respond to CFTR modulator therapy. R117H is a more prevalent rare mutation found in over 2,000 CF patients. In this study we investigated the effectiveness of VX-809/VX-770 therapy on restoring CFTR function in human bronchial epithelial (HBE) cells from R117H/F508del CF patients. We found that VX-809 stimulated more CFTR activity in R117H/F508del HBEs than in F508del/F508del HBEs. R117H expressed exclusively in immortalized HBEs exhibited a folding defect, was retained in the ER, and degraded prematurely. VX-809 corrected the R117H folding defect and restored channel function. Because R117 is involved in ion conductance, VX-770 acted additively with VX-809 to restore CFTR function in chronically treated R117H/F508del cells. Although treatment of R117H patients with VX-770 has been approved, our studies indicate that Orkambi may be more beneficial for rescue of CFTR function in these patients. Copyright © 2016 the American Physiological Society.

Estudio de la fotoabsorción y fotoionización de la molécula de alta relevancia atmosférica no a través de los estados Rydberg con la metodología MQDO

NASA Astrophysics Data System (ADS)

Bustos, E.; Velasco, A. M.; Martín, I.; Lavín, C.

Los procesos de fotoionización son de una importancia fundamental [1] y encuentran aplicación en un gran número de contextos científicos: Astrofísica [2], química de las radiaciones, biología. Los investigadores de dichos campos, necesitan de valores de fiables de secciones eficaces para la fotoionización parcial, la Fotoabsorción, así como para los procesos de fotofragmentación en amplios intervalos espectrales, particularmente en estudios de modelización [3-5]. En este trabajo se ha centrado la atención sobre el oxido nítrico, que se ha considerado apropiado y relevante por varios motivos: por el trascendental papel que representa en la física y química de la alta atmosfera [6], aparte de por estar íntimamente relacionado con los problemas de contaminación. Los procesos de recombinación disociativa [7] del NO, donde los estados Rydberg se encuentran directamente implicados, son relevantes, por ejemplo, en las regiones E y F de la ionosfera [7]. En este trabajo se estudia la fotoionización del NO desde el estado fundamental con la versión molecular del método del orbital de defecto cuántico (MQDO). Para ello se calcula el diferencial de las fuerzas de oscilador parciales que constituyen los canales de fotoionización del NO desde el estado fundamental. La continuidad del diferencial de fuerza de oscilador calculada a través del umbral de fotoionización, esto es, en las regiones del espectro discreta y del continua, se adopta como criterio de calidad la escasez de datos comparativos [8].

Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).

NASA Astrophysics Data System (ADS)

Menéndez, J. M.; Martín, I.; Velasco, A. M.

El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

[In Process Citation].

PubMed

Caravalí-Meza, Nuris Yohana; Jiménez-Cruz, Arturo; Bacardí-Gascón, Montserrat

2016-03-25

Antecedentes: se ha reportado una asociación entre el aumento del consumo de bebidas azucaradas y varias enfermedades metabólicas. Objetivo: evaluar el efecto del consumo de bebidas azucaradas sobre la obesidad en un periodo de 12 meses en mexicanos de 15 a 19 años. Métodos: el diseño del estudio fue prospectivo, con 12 meses de seguimiento. Se midieron el peso, la talla y la circunferencia de cintura (CC), y se calculó el puntaje z de índice de masa corporal (IMC). Se aplicó un cuestionario sobre consumo de 19 bebidas. Para evaluar la predicción del aumento de IMC y de CC como resultado del consumo de bebidas, se utilizó análisis de regresión logística binomial. Resultados: al final del estudio se evaluó al 89% (1.344). El promedio de edad fue de 15 años, 55% fueron mujeres. La prevalencia de sobre- peso y obesidad al final del estudio fue del 33%. Al final del estudio, un 25% de los participantes consumían más de 50 g de azúcar proveniente de las bebidas. Quienes consumieron 50 g de azúcar o más al día presentaron mayor riesgo de aumentar la CC ≥ 2 cm (RR = 1,19, IC 95%, 1,03-1,39, p = 0,02). Quienes mantuvieron el consumo de bebidas azucaradas durante 12 meses, al compararlo con los que disminuyeron el consumo a 10 g/día, presentaron 71% más probabilidades de aumentar a un puntaje de IMC ≥ 2 (RR = 1,71, IC 95%, 1,03-2,86, p = 0,039). Conclusión: el alto consumo de bebidas azucaradas aumentó las probabilidades de aumentar de peso y de circunferencia de cintura.

Tezacaftor/Ivacaftor in Subjects with Cystic Fibrosis and F508del/F508del-CFTR or F508del/G551D-CFTR.

PubMed

Donaldson, Scott H; Pilewski, Joseph M; Griese, Matthias; Cooke, Jon; Viswanathan, Lakshmi; Tullis, Elizabeth; Davies, Jane C; Lekstrom-Himes, Julie A; Wang, Linda T

2018-01-15

Tezacaftor (formerly VX-661) is an investigational small molecule that improves processing and trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in vitro, and improves CFTR function alone and in combination with ivacaftor. To evaluate the safety and efficacy of tezacaftor monotherapy and of tezacaftor/ivacaftor combination therapy in subjects with cystic fibrosis homozygous for F508del or compound heterozygous for F508del and G551D. This was a randomized, placebo-controlled, double-blind, multicenter, phase 2 study (NCT01531673). Subjects homozygous for F508del received tezacaftor (10 to 150 mg) every day alone or in combination with ivacaftor (150 mg every 12 h) in a dose escalation phase, as well as in a dosage regimen testing phase. Subjects compound heterozygous for F508del and G551D, taking physician-prescribed ivacaftor, received tezacaftor (100 mg every day). Primary endpoints were safety through Day 56 and change in sweat chloride from baseline through Day 28. Secondary endpoints included change in percent predicted FEV 1 (ppFEV 1 ) from baseline through Day 28 and pharmacokinetics. The incidence of adverse events was similar across treatment arms. Tezacaftor (100 mg every day)/ivacaftor (150 mg every 12 h) resulted in a 6.04 mmol/L decrease in sweat chloride and 3.75 percentage point increase in ppFEV 1 in subjects homozygous for F508del, and a 7.02 mmol/L decrease in sweat chloride and 4.60 percentage point increase in ppFEV 1 in subjects compound heterozygous for F508del and G551D from baseline through Day 28 (P < 0.05 for all). These results support continued clinical development of tezacaftor (100 mg every day) in combination with ivacaftor (150 mg every 12 h) in subjects with cystic fibrosis. Clinical trial registered with www.clinicaltrials.gov (NCT01531673).

Polymorphism of the NFKB1 affects the serum inflammatory levels of IL-6 in Hashimoto thyroiditis in a Turkish population.

PubMed

Koc, Arzuhan; Batar, Bahadir; Celik, Ozlem; Onaran, Ilhan; Tasan, Ertugrul; Sultuybek, Gonul Kanigur

2014-07-01

Hashimoto thyroiditis (HT) is a chronic inflammatory autoimmune disease of thyroid gland affected by interaction of multiple genes and various cytokines. Variants in the genes coding for the NFKB and IKB proteins can be potentially involved in the development of the inflammatory diseases. NFKB, a key transcription factor of the regulation of immune responses, is interesting candidate for association studies about autoimmune disorder. The aim of the present study was to investigate the relationship between NFKB1 and NFKBIA (NFKB1 inhibitor gene) polymorphisms, and the risk of HT in a Turkish Population in the context of IL-6 serum levels which may contribute to susceptibility to the disease. We analyzed the distribution of NFKB1-94ins/del ATTG and NFKBIA 3'UTR A→G polymorphisms using PCR-RFLP method and IL-6 serum levels using ELISA method in 120 HT patients and 190 healthy controls in Turkish population. Although, there was no statistical significant difference in distribution of the genotypes and alleles of NFKB1-94ins/del ATTG or NFKBIA 3'UTR A→G polymorphisms in patients and control subjects as single, ins/ins/GG combined genotype had protective effect on the disease when compared to ins/ins/AG combined genotype as combined genotypes of both polymorphisms. In addition to this finding, IL-6 serum levels in HT patients with del/del genotype were significantly higher than in patients with del/ins genotype (p<0.001). According to the combined genotype analysis of NFKB1-94ins/del ATTG and NFKBIA 3'UTR A→G polymorphisms, IL-6 levels were also higher in patients with del/del genotype when at least one G allele existing (p=0.007). Therefore, our findings suggest that the functional promoter NFKB1-94ins/del ATTG polymorphism was significantly associated with population HT disease through acting by directly modulating IL-6 serum levels. Copyright © 2014 Elsevier GmbH. All rights reserved.

Manual del McVCO 1999

USGS Publications Warehouse

McChesney, P.J.

1999-01-01

El McVCO es un generador de frecuencias basado en un microcontrolador que reemplaza al oscilador controlado por voltaje (VCO) utilizado en telemetría analógica de datos sísmicas. Acepta señales de baja potencia desde un sismómetro y produce una señal subportadora modulada en frecuencia adecuada para enlaces telefónicos o vía radio a un lugar remoto de recolección de datos. La frecuencia de la subportadora y la ganancia pueden ser seleccionadas mediante un interruptor. Tiene la opción de poder operar con dos canales para la observación con ganancia alta y baja. El McVCO fue diseñado con el propósito de mejorar la telemetría analógica de las señales dentro de la Pacific Northwest Seismograph Network (PNSN) (Red Sismográfica del Noroeste del Pacífico). Su desarrollo recibió el respaldo del Programa de Geofísica de la Universidad de Washington y del "Volcano Hazards and Earthquake Hazards programs of the United States Geological Survey (USGS) (Programa de Investigaciones de Riesgos Volcánicos y Programa de Investigaciones de Riesgos Sísmicos de los EEUU). Cientos de instrumentos se han construido e instalado. Además de utilizarlo el PNSN, el McVCO es usado por el Observatorio Vulcanológico de Alaska para monitorear los volcanes aleutianos y por el USGS Volcano Disaster Assistance Program (Programa de Ayuda en las Catástrofes Volcánicas del USGS) para responder a crisis volcánicas en otros países. Este manual cubre el funcionamiento del McVCO, es una referencia técnica para aquellos que necesitan saber con más detalle cómo funciona el McVCO, y cubre una serie de temas que requieren un trato explícito o que derivan del despliegue del instrumento.

Analysis of density and epitopes of D antigen on the surface of erythrocytes from DEL phenotypic individuals carrying the RHD1227A allele.

PubMed

Gu, Juan; Sun, An-Yuan; Wang, Xue-Dong; Shao, Chao-Peng; Li, Zheng; Huang, Li-Hua; Pan, Zhao-Lin; Wang, Qing-Ping; Sun, Guang-Ming

2014-04-01

The characteristics of the D antigen are important as they influence the immunogenicity of D variant cells. Several studies on antigenic sites have been reported in normal D positive, weak D and partial D cases, including a comprehensive analysis of DEL types in Caucasians. The aim of this study was to assess D antigen density and epitopes on the erythrocyte surface of Asian type DEL phenotypic individuals carrying the RHD1227A allele in the Chinese population. A total of 154 DEL phenotypic individuals carrying the RHD1227A allele were identified through adsorption and elution tests and polymerase chain reaction analysis with sequence-specific primers in the Chinese population. D antigen density on the erythrocyte surface of these individuals was detected using a flow cytometric method. An erythrocyte sample with known D antigen density was used as a standard. Blood samples from D-negative and D-positive individuals were used as controls. In addition, D antigen epitopes on the erythrocyte surface of DEL individuals carrying the RHD1227A allele were investigated with 18 monoclonal anti-D antibodies specific for different D antigen epitopes. The means of the median fluorescence intensity of D antigen on the erythrocyte membrane surface of D-negative, D-positive and DEL individuals were 2.14±0.25, 193.61±11.43 and 2.45±0.82, respectively. The DEL samples were estimated to have approximately 22 D antigens per cell. The samples from all 154 DEL individuals reacted positively with 18 monoclonal anti-D antibodies specific for different D antigen epitopes. In this study, D antigen density on the erythrocyte surface of DEL individuals carrying the RHD1227A allele was extremely low, there being only very few antigenic molecules per cell, but the D antigen epitopes were grossly complete.

The CHEK2 del5395 is a founder mutation without direct effects for cancer risk in the latvian population.

PubMed

Plonis, J; Kalniete, D; Nakazawa-Miklasevica, M; Irmejs, A; Vjaters, E; Gardovskis, J; Miklasevics, E

2015-12-01

Our objective was to determine: 1) whether the checkpoint kinase 2 ( CHEK2 ) del5395 (g.27417113-27422508 del, NC_000022.11) is a founder mutation in the Latvian population, 2) if there is an association between CHEK2 del5395 mutation and cancer risk, and 3) and whether the CHEK2 del5395 mutation impacts cancer predisposition in Chernobyl disaster liquidators (the civil and military personnel who were called upon to deal with consequences of the 1986 nuclear disaster) as well as geriatric populations. We recruited 438 breast cancer patients, 568 colorectal cancer patients, 399 ovarian cancer patients, 419 prostate cancer patients, 526 healthy blood donors, 480 Chernobyl disaster liquidators and 444 geriatric cancer-free participants. DNA samples were isolated from blood samples and subjected to multiplex polymerase chain reaction (PCR). The truncation of del5395 was estimated by fragment size of the multiplex PCR.All groups were compared to the healthy blood donors using Fisher's exact test. All p values were two-sided and the odds ratios (OR) calculated by two-by-two table. In cancer groups, the del5395 mutation was most frequently observed in the ovarian cancer group (1.00%, OR = 1.32). In control groups, the del5395 mutation was most frequent (0.76%) in the healthy donors, which exceeded its frequency in the Chernobyl liquidators group and the geriatric group by 0.01 and 0.08%, respectively. For all groups, the OR appeared to be >1 only in ovarian cancer patients. However, OR rates showed no statistical significance in either cancer or control groups, with the p value fluctuating within the range of 0.39-1.00. The CHEK2 gene del5395 is a founder mutation in the Latvian population, which, however, does not have a direct impact on genetic predisposition toward colorectal, breast, ovarian and prostate cancer.

Weyl fermions in a family of Gödel-type geometries with a topological defect

NASA Astrophysics Data System (ADS)

Garcia, G. Q.; Oliveira, J. R. De S.; Furtado, C.

In this paper, we study Weyl fermions in a family of Gödel-type geometries in Einstein general relativity. We also consider that these solutions are embedded in a topological defect background. We solve the Weyl equation and find the energy eigenvalues and eigenspinors for all three cases of Gödel-type geometries where a topological defect is passing through them. We show that the presence of a topological defect in these geometries contributes to the modification of the spectrum of energy. The energy zero modes for all three cases of the Gödel geometries are discussed.

Observaciones del CH interestelar y el continuo en 3,3 GHz

NASA Astrophysics Data System (ADS)

Olano, C. A.; Combi, J. A.; Pöppel, W.; Benaglia, P.; Sanz, A. J.; Bava, J. A.

Se informa sobre el proyecto que se lleva a cabo en el IAR con el propósito de observar las líneas hiperfinas del estado fundamental del CH y el continuo en la banda de 3,3 GHz. El nuevo receptor construído en nuestro laboratorio para tal fin se instaló sobre uno de los radiotelescopios, funcionando conjuntamente con los sistemas de procesamiento actuales del IAR. Los resultados de las primeras observaciones, realizadas tanto en las líneas espectrales como en el continuo sobre fuentes conocidas, fueron satisfactorios.

Study of Aerospace Materials, Coatings, Adhesions and Processes. Aircraft Icing Processes. Volume 2.

DTIC Science & Technology

1984-09-14

la direccio’n del eje de la son - da. DATOS ELECTRICOS Rint’erna 20.26 . R(OC) =5.35 Q R(22 0 C).. 5.93 Q R(100 0 C) 7.43 . Roperacio’n... son las constantes de calibraci6n propias del sensor. 1INT A FN. de Informe I-231/S10/84.076Pg. . La temperatura de funcionamiento se deterrnin6 por l...funcionamiento del sensor, T la temperatura ambiente, la densidad y v la velocidad. A, B y n son las constantes de cal- z braci6n propias del

Contribución al flujo infrarrojo de las estrellas Be de la recombinación dielectrónica del MgII

NASA Astrophysics Data System (ADS)

Cruzado, A.; di Rocco, H.; Ringuelet, A.

Para evaluar la contribución del proceso de recombinación dielectrónica del átomo de MgII al exceso de flujo infrarrojo observado en las estrellas Be, calculamos la energía emitida en las líneas originadas por este proceso. Se evaluaron los efectos de las condiciones físicas del medio, como la temperatura electrónica y la densidad electrónica, sobre el flujo emitido. Se consideró también la influencia de una posible opacidad.

Clinical outcomes of EGFR-TKI treatment and genetic heterogeneity in lung adenocarcinoma patients with EGFR mutations on exons 19 and 21.

PubMed

Yu, Jiang-Yong; Yu, Si-Fan; Wang, Shu-Hang; Bai, Hua; Zhao, Jun; An, Tong-Tong; Duan, Jian-Chun; Wang, Jie

2016-03-21

Epidermal growth factor receptor (EGFR) mutations, including a known exon 19 deletion (19 del) and exon 21 L858R point mutation (L858R mutation), are strong predictors of the response to EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment in lung adenocarcinoma. However, whether patients carrying EGFR 19 del and L858R mutations exhibit different responsiveness to EGFR-TKIs and what are the potential mechanism for this difference remain controversial. This study aimed to investigate the clinical outcomes of EGFR-TKI treatment in patients with EGFR 19 del and L858R mutations and explore the genetic heterogeneity of tumors with the two mutation subtypes. Of 1127 patients with advanced lung adenocarcinoma harboring EGFR 19 del or L858R mutations, 532 received EGFR-TKI treatment and were included in this study. EGFR 19 del and L858R mutations were detected by using denaturing high-performance liquid chromatography (DHPLC). T790M mutation, which is a common resistant mutation on exon 20 of EGFR, was detected by amplification refractory mutation system (ARMS). Next-generation sequencing (NGS) was used to explore the genetic heterogeneity of tumors with EGFR 19 del and L858R mutations. Of the 532 patients, 319 (60.0%) had EGFR 19 del, and 213 (40.0%) had L858R mutations. The patients with EGFR 19 del presented a significantly higher overall response rate (ORR) for EGFR-TKI treatment (55.2% vs. 43.7%, P = 0.017) and had a longer progression-free survival (PFS) after first-line EGFR-TKI treatment (14.4 vs. 11.4 months, P = 0.034) compared with those with L858R mutations. However, no statistically significant difference in overall survival (OS) was observed between the two groups of patients. T790M mutation status was analyzed in 88 patients before EGFR-TKI treatment and 134 after EGFR-TKI treatment, and there was no significant difference in the co-existence of T790M mutation with EGFR 19 del and L858R mutations before EGFR-TKI treatment (5.6% vs. 8.8%, P = 0.554) or after treatment (24.4% vs. 35.4%, P = 0.176). In addition, 24 patients with EGFR 19 del and 19 with L858R mutations were analyzed by NGS, and no significant difference in the presence of multiple somatic mutations was observed between the two genotypes. Patients with EGFR 19 del exhibit longer PFS and higher ORR compared with those with L858R mutations. Whether the heterogeneity of tumors with EGFR 19 del and L858R mutations contribute to a therapeutic response difference needs further investigation.

[In defense of psychiatric reform: for the dawn of a new unavoidable future].

PubMed

de Paiva, Ilana Lemos; Yamamoto, Oswaldo H

2007-01-01

This work comprises a study into the historic process of implementation of psychiatric reforms in Rio Grande do Norte state, highlighting the agents involved, their careers, achievements and progress and this movement's current prospectsfor realizing the ideal of reintegrating mental health patients in society. It is necessary to comprehend the process that took place within the Municipal Health Department starting in 1992, since this experience was the driving force for reflections upon psychiatric reform across the state. This is followed by a documental analysis of reports, legislation and dossiers, as well as the collection of depositions by people involved in the process with a view to building up the identity of the social agents and analyzing their perceptions of the facts, highlighting congruencies and incongruencies concerning the history of the local psychiatric reform.

M2 tidal effects in greater cook strait, New Zealand

NASA Astrophysics Data System (ADS)

Kibblewhite, Alick C.; Ash, David E.

1980-05-01

The application of a M2 nonlinear numerical tidal model to the shelf seas of central New Zealand (~38.500 km2 area) is described. It has provided a preliminary assessment of tidal and residual currents, bottom stress, energy dissipation, and the stratification index. The existence of a permanent, tidally driven mesoscale eddy (~75 km diameter) is predicted nort of D'Urville Island. Large spatial gradients in bottom stress qualitatively agree with many features of the surficial sediment distribution. A comparison of all available bulk stratification data with the h/u3 stratification index clearly demonstrates the dominance of tidal versus wind mixing over the control of summer stratification. A potential application of the model to fisheries science is suggested through a comparison of the stratification index contour map and some observations of squid fishing vessel locations.

Reference Aid Abbreviations in the Latin American Press

DTIC Science & Technology

1977-08-30

FTC Frente de Trabajadores de la Cultura Frente de Trabajadores Copeyanos FTCCP Federacion de Trabajadores en Construccion Civil del Peru...Naciones Unidas ACOLSURE Asociacion Colombiana de Suboficiales de las Fuerzas Militares en Retiro ACOMINAS Aco Minas Gerais S.A. ACOPECAFE...28 CAMACOL Camara Colombiana de la Construccion CAMAS Coordinador del Area Maritima del Atlantico Sur CAME Colombian Chamber of

Discourse of His Excellency the President of the Republic of Chile, Don Eduardo Frei Ruiz-Tagle

NASA Astrophysics Data System (ADS)

1999-06-01

Es una gran satisfacción para mí inaugurar lo que será, dentro de breve tiempo, el telescopio más poderoso del mundo, que viene a responder tan claramente a la necesidad esencial del ser humano de explorar y conocer los orígenes y misterios del universo.

77 FR 2606 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to Executive Order 12978

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-18

.... RENTERIA CAICEDO, Beatriz Eugenia, c/o INVERSIONES AGROINDUSTRIALES DEL OCCIDENTE LTDA., Bogota, Colombia... ILOVIN S.A., Bogota, Colombia; c/o INVERSIONES DEL PRADO ABDALA SAIEH Y CIA. S.C.A., Barranquilla...., Bogota, Colombia; c/o INVERSIONES DEL PRADO ABDALA SAIEH Y CIA. S.C.A., Barranquilla, Colombia; c/o KAREN...

IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951.

PubMed

Clappier, E; Grardel, N; Bakkus, M; Rapion, J; De Moerloose, B; Kastner, P; Caye, A; Vivent, J; Costa, V; Ferster, A; Lutz, P; Mazingue, F; Millot, F; Plantaz, D; Plat, G; Plouvier, E; Poirée, M; Sirvent, N; Uyttebroeck, A; Yakouben, K; Girard, S; Dastugue, N; Suciu, S; Benoit, Y; Bertrand, Y; Cavé, H

2015-11-01

The added value of IKZF1 gene deletion (IKZF1(del)) as a stratifying criterion in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is still debated. We performed a comprehensive analysis of the impact of IKZF1(del) in a large cohort of children (n=1223) with BCR-ABL1-negative BCP-ALL treated in the EORTC-CLG trial 58951. Patients with IKZF1(del) had a lower 8-year event-free survival (EFS, 67.7% versus 86.5%; hazard ratio (HR)=2.41; 95% confidence interval (CI)=1.75-3.32; P<0.001). Importantly, despite association with high-risk features such as high minimal residual disease, IKZF1(del) remained significantly predictive in multivariate analyses. Analysis by genetic subtype showed that IKZF1(del) increased risk only in the high hyperdiploid ALLs (HR=2.57; 95% CI=1.19-5.55; P=0.013) and in 'B-other' ALLs, that is, lacking classifying genetic lesions (HR=2.22; 95% CI=1.45-3.39; P<0.001), the latter having then a dramatically low 8-year EFS (56.4; 95% CI=44.6-66.7). Among IKZF1(del)-positive patients randomized for vincristine-steroid pulses during maintenance, those receiving pulses had a significantly higher 8-year EFS (93.3; 95% CI=61.3-99.0 versus 42.1; 95% CI=20.4-62.5). Thus, IKZF1(del) retains independent prognostic significance in the context of current risk-adapted protocols, and is associated with a dismal outcome in 'B-other' ALL. Addition of vincristine-steroid pulses during maintenance may specifically benefit to IKZF1(del) patients in preventing relapses.

Delphinidin, a dietary antioxidant, induces human epidermal keratinocyte differentiation but not apoptosis: studies in submerged and three-dimensional epidermal equivalent models.

PubMed

Chamcheu, Jean Christopher; Afaq, Farrukh; Syed, Deeba N; Siddiqui, Imtiaz A; Adhami, Vaqar M; Khan, Naghma; Singh, Sohinderjit; Boylan, Brendan T; Wood, Gary S; Mukhtar, Hasan

2013-05-01

Delphinidin (Del), [3,5,7,3'-,4'-,5'-hexahydroxyflavylium], an anthocyanidin and a potent antioxidant abundantly found in pigmented fruits and vegetables exhibits proapoptotic effects in many cancer cells. Here, we determined the effect of Del on growth, apoptosis and differentiation of normal human epidermal keratinocytes (NHEKs) in vitro in submerged cultures and examined its effects in a three-dimensional (3D) epidermal equivalent (EE) model that permits complete differentiation reminiscent of in vivo skin. Treatment of NHEKs with Del (10-40 μm; 24-48 h) significantly enhanced keratinocyte differentiation. In Del-treated cells, there was marked increase in human involucrin (hINV) promoter activity with simultaneous increase in the mRNA and protein expressions of involucrin and other epidermal differentiation markers including procaspase-14 and transglutaminase-1 (TGM1), but without any effect on TGM2. Del treatment of NHEKs was associated with minimal decrease in cell viability, which was not associated with apoptosis as evident by lack of modulation of caspases, apoptosis-related proteins including Bcl-2 family of proteins and poly(ADP-ribose) polymerase cleavage. To establish the in vivo relevance of our observations in submerged cultures, we then validated these effects in a 3D EE model, where Del was found to significantly enhance cornification and increase the protein expression of cornification markers including caspase-14 and keratin 1. For the first time, we show that Del induces epidermal differentiation using an experimental system that closely mimics in vivo human skin. These observations suggest that Del could be a useful agent for dermatoses associated with epidermal barrier defects including aberrant keratinization, hyperproliferation or inflammation observed in skin diseases like psoriasis and ichthyoses. © 2013 John Wiley & Sons A/S.

Development and validation of an automated delirium risk assessment system (Auto-DelRAS) implemented in the electronic health record system.

PubMed

Moon, Kyoung-Ja; Jin, Yinji; Jin, Taixian; Lee, Sun-Mi

2018-01-01

A key component of the delirium management is prevention and early detection. To develop an automated delirium risk assessment system (Auto-DelRAS) that automatically alerts health care providers of an intensive care unit (ICU) patient's delirium risk based only on data collected in an electronic health record (EHR) system, and to evaluate the clinical validity of this system. Cohort and system development designs were used. Medical and surgical ICUs in two university hospitals in Seoul, Korea. A total of 3284 patients for the development of Auto-DelRAS, 325 for external validation, 694 for validation after clinical applications. The 4211 data items were extracted from the EHR system and delirium was measured using CAM-ICU (Confusion Assessment Method for Intensive Care Unit). The potential predictors were selected and a logistic regression model was established to create a delirium risk scoring algorithm to construct the Auto-DelRAS. The Auto-DelRAS was evaluated at three months and one year after its application to clinical practice to establish the predictive validity of the system. Eleven predictors were finally included in the logistic regression model. The results of the Auto-DelRAS risk assessment were shown as high/moderate/low risk on a Kardex screen. The predictive validity, analyzed after the clinical application of Auto-DelRAS after one year, showed a sensitivity of 0.88, specificity of 0.72, positive predictive value of 0.53, negative predictive value of 0.94, and a Youden index of 0.59. A relatively high level of predictive validity was maintained with the Auto-DelRAS system, even one year after it was applied to clinical practice. Copyright © 2017. Published by Elsevier Ltd.

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.

PubMed

De Stefano, Daniela; Villella, Valeria R; Esposito, Speranza; Tosco, Antonella; Sepe, Angela; De Gregorio, Fabiola; Salvadori, Laura; Grassia, Rosa; Leone, Carlo A; De Rosa, Giuseppe; Maiuri, Maria C; Pettoello-Mantovani, Massimo; Guido, Stefano; Bossi, Anna; Zolin, Anna; Venerando, Andrea; Pinna, Lorenzo A; Mehta, Anil; Bona, Gianni; Kroemer, Guido; Maiuri, Luigi; Raia, Valeria

2014-01-01

Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures rescue the functional expression of the most frequent pathogenic CFTR mutant, F508del, at the respiratory epithelial surface and reduce lung inflammation in Cftr(F508del) homozygous mice. Cysteamine, the reduced form of cystamine, is an FDA-approved drug. Here, we report that oral treatment with cysteamine greatly reduces the mortality rate and improves the phenotype of newborn mice bearing the F508del-CFTR mutation. Cysteamine was also able to increase the plasma membrane expression of the F508del-CFTR protein in nasal epithelial cells from F508del homozygous CF patients, and these effects persisted for 24 h after cysteamine withdrawal. Importantly, this cysteamine effect after washout was further sustained by the sequential administration of epigallocatechin gallate (EGCG), a green tea flavonoid, both in vivo, in mice, and in vitro, in primary epithelial cells from CF patients. In a pilot clinical trial involving 10 F508del-CFTR homozygous CF patients, the combination of cysteamine and EGCG restored BECN1, reduced SQSTM1 levels and improved CFTR function from nasal epithelial cells in vivo, correlating with a decrease of chloride concentrations in sweat, as well as with a reduction of the abundance of TNF/TNF-alpha (tumor necrosis factor) and CXCL8 (chemokine [C-X-C motif] ligand 8) transcripts in nasal brushing and TNF and CXCL8 protein levels in the sputum. Altogether, these results suggest that optimal schedules of cysteamine plus EGCG might be used for the treatment of CF caused by the F508del-CFTR mutation.

Four SNPs and Systemic Level of FOXP3 in Smokers and Patients with Chronic Obstructive Pulmonary Disease.

PubMed

Chu, Shuyuan; Zhong, Xiaoning; Zhang, Jianquan; Lai, Xiaoying; Xie, Jiajun; Li, Yu

2016-12-01

Forkhead box P3 (FOXP3) is the essential transcription factor for the function of regulatory T-cell (Treg). However, the gene mutation of FOXP3 in patients with chronic obstructive pulmonary disease (COPD) at different stages has not been reported. We aim to investigate four single nucleotide polymorphisms (SNPs) and the mRNA expression of FOXP3 in smokers with normal lung function and smokers with COPD at different stages. FOXP3 mRNA expression and SNPs in FOXP3 were assessed in nonsmokers with normal lung function (N), smokers with normal lung function (S), smokers with COPD in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 or 2 grade (COPD 1-2), and smokers with COPD in GOLD 3 or 4 grade (COPD 3-4). In peripheral blood sample, FOXP3 mRNA was assessed using real-time quantitative PCR and SNPs were analyzed by TaqMan PCR. FOXP3 mRNA level in peripheral blood sample was decreased when COPD was aggravated. The frequency of FOXP3 rs5902434 genotype del/del and allele del are lower in COPD 1-2 and COPD 3-4 than that in N or S. The rs5902434 genotype del/del and allele del were, respectively, associated with decreased risk of COPD and lung function decline. The rs5902434 genotypic distribution was correlated with FOXP3 mRNA level. In conclusion, both FOXP3 rs5902434 genotypes and alleles were differently distributed in COPD patients and smokers with normal lung function. The distribution of del/del genotype was associated with systemic expression of FOXP3 mRNA. More research is needed to explore the role of FOXP3 gene polymorphism in immunoinflammation of COPD.

Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitors.

PubMed

Wilke, Martina; Bot, Alice; Jorna, Huub; Scholte, Bob J; de Jonge, Hugo R

2012-01-01

Most patients with Cystic Fibrosis (CF) carry at least one allele with the F508del mutation, resulting in a CFTR chloride channel protein with a processing, gating and stability defect, but with substantial residual activity when correctly sorted to the apical membranes of epithelial cells. New therapies are therefore aimed at improving the folding and trafficking of F508del CFTR, (CFTR correctors) or at enhancing the open probability of the CFTR chloride channel (CFTR potentiators). Preventing premature breakdown of F508del CFTR is an alternative or additional strategy, which is investigated in this study. We established an ex vivo assay for murine F508del CFTR rescue in native intestinal epithelium that can be used as a pre-clinical test for candidate therapeutics. Overnight incubation of muscle stripped ileum in modified William's E medium at low temperature (26°C), and 4 h or 6 h incubation at 37°C with different proteasome inhibitors (PI: ALLN, MG-132, epoxomicin, PS341/bortezomib) resulted in fifty to hundred percent respectively of the wild type CFTR mediated chloride secretion (forskolin induced short-circuit current). The functional rescue was accompanied by enhanced expression of the murine F508del CFTR protein at the apical surface of intestinal crypts and a gain in the amount of complex-glycosylated CFTR (band C) up to 20% of WT levels. Sustained rescue in the presence of brefeldin A shows the involvement of a post-Golgi compartment in murine F508del CFTR degradation, as was shown earlier for its human counterpart. Our data show that proteasome inhibitors are promising candidate compounds for improving rescue of human F508del CFTR function, in combination with available correctors and potentiators.

Características del viento en estrellas Be derivadas del perfil Hα

NASA Astrophysics Data System (ADS)

Rohrmann, R.; Cidale, L.

El estudio teórico de perfiles Hα y su variabilidad en estrellas Be ha sido frecuentemente desarrollado en base a modelos de envolturas circunestelares inhomogéneas, donde la geometría del material es responsable de la forma del perfil dependiendo de la dirección de observación. Nosotros damos una interpretación alternativa y proponemos que la mayoría de las propiedades de esta línea tienen origen en la base de un viento estelar y de una estructura cromosférica anexa a la fotósfera. Encontramos que típicos perfiles Hα en Be, como son los llamados pole-on y winebottle, pueden ser reproducidos cualitativamente sin recurrir a la existencia de una envoltura asimétrica. Analizamos como la línea Hα permite identificar la posible estructura del viento en la región donde éste se inicia.

Espectro de radiación derivado de un modelo de colapso protoestelar

NASA Astrophysics Data System (ADS)

Coca, S.; Rohrmann, R.

El exceso de emisión infrarroja en objetos protoestelares es atribuido usualmente a un disco de material en torno al cuerpo central. A pesar del avance alcanzado en la elaboración de modelos, aún existen dificultades para explicar la ley de temperatura del disco necesaria para reproducir las luminosidades y perfiles de energía observados. Nuestra propuesta consiste en determinar la distribución espectral de la radiación derivada de un particular modelo de colapso protoestelar, y estudiar la evolución del espectro desde estadíos tempranos de la contracción gravitatoria. Este plan es orientado a evaluar las propiedades del modelo (distribuciones de masa y temperatura del material circunestelar) por comparación con datos observacionales, a fin de inferir de ello los posibles ajustes requeridos en la teoría actualmente empleada.