Quantifying the Spatial and Seasonal Hydrodynamics of Subsurface Soil Salinity and Selenium Mobilization in the Pariette Watershed, Uintah Basin, UT

NASA Astrophysics Data System (ADS)

Amakor, X. N.; Jacobson, A. R.; Cardon, G. E.; Grossl, P. R.

2011-12-01

A recent water quality report recognized concentrations of salts and selenium above total maximum daily loads (TMDLs) in the Pariette Wetlands located in the Uintah Basin, Utah. Since the wetlands are located in the Pacific Migratory Flyway and frequented by numerous water fowl, the elevated levels of total dissolved solids and Se are of concern. To determine whether it possible to manage the mobilization of salts and associated contaminants through the watershed soils into the Pariette Wetlands, knowledge of the spatio-temporal dynamics and distribution of these contaminants is required. Thus, the objective of this study is to characterize the spatio-temporal mobilization of salts and total selenium in the Pariette Draw watershed. Intensive soil information is being collected along the streams feeding the wetlands from fields representing the dominant land-uses in the watershed (irrigated agricultural fields, fallow salt-crusted fields, oil and natural gas extraction fields) using both the noninvasive electromagnetic induction (EMI) sensing technique (EM38DD) and the invasive time-domain reflectometry (TDR). At each site, ground truth samples were collected from optimally determined points generated using the ESAP-RSSD program based on the bulk soil electrical conductivity survey information. Stable soil properties affecting the measurement of salinity (e.g., clay content, organic matter content, cation exchange capacity, bulk density) were also characterized at these points. Parameters affected by fluctuations in soil moisture content (e.g., pH, electrical conductivity of saturation paste extract (ECe), dissolved organic carbon (DOC), and total selenium in the dissolved saturation extract) are being measured repeatedly over a minimum of 1 year. Based on regression models of collocated EMI, TDR and ECe measurements, the dense survey data are transformed into ECe. Geostatistical kriging methods are applied to the transformed ECe and volumetric water content to reveal the complex spatio-temporal patterns of salinity, water content, and total selenium (based on the association between ECe and total Se) across portions of the watershed. Temporal changes are being compared using the paired t-test. Here we present the spatio-temporal correlations among the properties and over the sampling times for the 2011 summer and fall seasons with an initial evaluation of the underlying processes contributing to the elevated contaminant loads at the wetlands. Additional measurements will be made in 2012 to capture the effects of early spring snowmelt and runoff.

Summary of ECE presentations at EC-18

DOE PAGES

Taylor, G.

2015-03-12

There were nine ECE and one EBE presentation at EC-18. Four of the presentations were on various aspects of ECE on ITER. The ITER ECE diagnostic has entered an important detailed preliminary design phase and faces several design challenges in the next 2-3 years. Most of the other ECE presentations at the workshop were focused on applications of ECE diagnostics to plasma measurements, rather than improvements in technology, although it was apparent that heterodyne receiver technology continues to improve. CECE, ECE imaging and EBE imaging are increasingly providing valuable insights into plasma behavior that is important to understand if futuremore » burning plasma devices, such as ITER, FNSF and DEMO, are to be successful.« less

Lactoferricin B-derived peptides with inhibitory effects on ECE-dependent vasoconstriction.

PubMed

Fernández-Musoles, Ricardo; López-Díez, José Javier; Torregrosa, Germán; Vallés, Salvador; Alborch, Enrique; Manzanares, Paloma; Salom, Juan B

2010-10-01

Endothelin-converting enzyme (ECE), a key peptidase in the endothelin (ET) system, cleaves inactive big ET-1 to produce active ET-1, which binds to ET(A) receptors to exert its vasoconstrictor and pressor effects. ECE inhibition could be beneficial in the treatment of hypertension. In this study, a set of eight lactoferricin B (LfcinB)-derived peptides, previously characterized in our laboratory as angiotensin-converting enzyme (ACE) inhibitory peptides, was examined for their inhibitory effects on ECE. In vitro inhibitory effects on ECE activity were assessed using both the synthetic fluorogenic peptide substrate V (FPS V) and the natural substrate big ET-1. To study vasoactive effects, an ex vivo functional assay was developed using isolated rabbit carotid artery segments. With FPS V, only four LfcinB-derived peptides induced inhibition of ECE activity, whereas the eight peptides showed ECE inhibitory effects with big ET-1 as substrate. Regarding the ex vivo assays, six LfcinB-derived peptides showed inhibition of big ET-1-induced, ECE-dependent vasoconstriction. A positive correlation between the inhibitory effects of LfcinB-derived peptides on ECE activity when using big ET-1 and the inhibitory effects on ECE-dependent vasoconstriction was shown. ECE-independent vasoconstriction induced by ET-1 was not affected, thus discarding effects of LfcinB-derived peptides on ET(A) receptors or intracellular signal transduction mechanisms. In conclusion, a combined in vitro and ex vivo method to assess the effects of potentially antihypertensive peptides on the ET system has been developed and applied to show the inhibitory effects on ECE-dependent vasoconstriction of six LfcinB-derived peptides, five of which were dual vasopeptidase (ACE/ECE) inhibitors. Copyright © 2010 Elsevier Inc. All rights reserved.

The effects of ECE on the benefits of PMRT for breast cancer patients with positive axillary nodes.

PubMed

Geng, Wenwen; Zhang, Bin; Li, Danhua; Liang, Xinrui; Cao, Xunchen

2013-07-01

The purpose of the present study was to retrospectively evaluate the effects of extracapsular extension (ECE) on the benefits of post-mastectomy radiation therapy (PMRT) for groups of patients with varying numbers of positive axillary nodes (1-3, 4-9 and ≥10 positive axillary nodes). A total of 1220 axillary node-positive patients who had received mastectomy were involved in this study. Patients were grouped as 'Radio + /ECE + ', 'Radio-/ECE + ', 'Radio + /ECE-' or 'Radio-/ECE-' according to status of ECE and whether receiving PMRT or not, and were evaluated in terms of local region relapse (LRR) rate. The 5-year and 10-year Kaplan-Meier disease-free survival and overall survival (OS) rates were analyzed. ECE-positive differed from ECE-negative groups with statistical significance for all comparisons in favor of the ECE-negative group: 5-year locoregional failure-free survival (LRFFS) (82.69% vs 91.83%, P < 0.001), 10-year LRFFS (75.39% vs 90.02%, P < 0.001); 5-year OS (52.12% vs 74.46%, P < 0.001), 10-year OS (35.17% vs 67.63%, P < 0.001). There were no significant effects of ECE on the benefits of PMRT for patients with 1-3 (P = 0.5720), ≥10(P = 0.0614) positive axillary nodes. However, for the group of patients with 4-9 positive axillary nodes, ECE status had a significant effect on the benefits of PMRT with respect to 5-year and 10-year LRFFS (P < 0.05). In our study, regardless of the ECE status, PMRT didn't significantly improve the LRFFS for patients with 1-3 or ≥10 positive axillary nodes. However, for patients with 4-9 positive axillary nodes, ECE could be an important criterion to consider when deciding whether to receive PMRT.

Stable isotope and pen feeding trial studies confirm the value of horseshoe crab Limulus polyphemus eggs to spring migrant shorebirds in Delaware Bay

USGS Publications Warehouse

Haramis, G.M.; Link, W.A.; Osenton, P.C.; Carter, Daniel B.; Weber, R.G.; Clark, N.A.; Teece, M.A.; Mizrahi, D.S.

2007-01-01

We used stable isotope (SI) methods in combination with pen feeding trials to determine the importance of eggs of the Atlantic horseshoe crab Limulus polyphemus to migratory fattening of red knots Calidris canutus rufa and ruddy turnstones Arenaria interpres morinella during spring stopover in Delaware Bay. By manifesting measurable fractionation (ca +3?) and rapid turnover, blood plasma *15 nitrogen proved a functional marker for SI diet tracking during the short 3-week stopover. Blood samples from free-ranging knots (3 data sets) and turnstones (1 data set) produced similar convergence of plasma *15 N signatures with increasing body mass that indicated highly similar diets. Asymptotes deviated slightly (0.3? to 0.7?) from that of captive shorebirds fed a diet of only crab eggs during stopover, thus confirming a strong crab egg-shorebird linkage. The plasma *15N crab-egg diet asymptote was enriched ca +4.5? and therefore readily discriminated from that of either blue mussels Mytilus edulis or coquina clams Donax variabilis, the most likely alternative prey of knots in Delaware Bay. Crab eggs were highly palatable to captive knots and turnstones which achieved rates of mass gain (3?11 g/d) comparable to that of free-ranging birds. Peak consumption rates during hyperphagic events were 23,940 and 19,360 eggs/bird/d, respectively. The empirical conversions of eggs consumed to body mass gained (5,017 eggs/g for knots and 4,320 eggs/g for turnstones) indicate the large quantities of crab eggs required for the maintenance of these shorebird populations during stopover.

Fractures and stresses in Bone Spring sandstones

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warpinski, N.R.; Sattler, A.R.; Lorenz, J.C.

This project was a collaboration between Sandia National Laboratories and the Harvey E. Yates Company (Heyco), Roswell, NM, conducted under the auspices of Department of Energy's Oil Recovery Technology Partnership. The project applied Sandia perspectives on the effects of natural fractures, stress, and sedimentology for the stimulation and production of low permeability gas reservoirs to low permeability oil reservoirs, such as those typified by the Bone Spring sandstones of the Delaware Basin, southeast New Mexico. This report details the results and analyses obtained in 1990 from core, logs, stress, and other data taken from three additional development wells. An overallmore » summary gives results from all five wells studied in this project in 1989--1990. Most of the results presented are believed to be new information for the Bone Spring sandstones.« less

Tackling extremes: challenges for ecological and evolutionary research on extreme climatic events.

PubMed

Bailey, Liam D; van de Pol, Martijn

2016-01-01

Extreme climatic events (ECEs) are predicted to become more frequent as the climate changes. A rapidly increasing number of studies - though few on animals - suggest that the biological consequences of ECEs can be severe. However, ecological research on the impacts of ECEs has been limited by a lack of cohesiveness and structure. ECEs are often poorly defined and have often been confusingly equated with climatic variability, making comparison between studies difficult. In addition, a focus on short-term studies has provided us with little information on the long-term implications of ECEs, and the descriptive and anecdotal nature of many studies has meant it is still unclear what the key research questions are. Synthesizing the current state of work is essential to identify ways to make progress. We conduct a synthesis of the literature and discuss conceptual and practical challenges faced by research on ECEs. We consider three steps to advance research. First, we discuss the importance of choosing an ECE definition and identify the pros and cons of 'climatological' and 'biological' definitions of ECEs. Secondly, we advocate research beyond short-term descriptive studies to address questions concerning the long-term implications of ECEs, focussing on selective pressures and phenotypically plastic responses and how they might differ from responses to a changing climatic mean. Finally, we encourage a greater focus on multi-event studies that help us understand the implications of changing patterns of ECEs, through the combined use of modelling, experimental and observational field studies. This study aims to open a discussion on the definitions, questions and methods currently used to study ECEs, which will lead to a more cohesive approach to future ECE research. © 2015 The Authors. Journal of Animal Ecology © 2015 British Ecological Society.

Early Childhood Leadership through the Lens of Distributed Leadership

ERIC Educational Resources Information Center

Heikka, Johanna; Hujala, Eeva

2013-01-01

This study aims to investigate distribution of responsibilities for leadership in early childhood education (ECE) context. It focuses on the enactments of leadership by investigating how ECE stakeholders, e.g. teachers, ECE centre directors and administrative ECE leaders in municipalities perceive the leadership responsibilities. Using focus…

Inclusion in Early Childhood Education: A Zimbabwean Perspective

ERIC Educational Resources Information Center

Majoko, Tawanda

2017-01-01

The current study examined Early Childhood Education (ECE) teachers' understanding, attitudes and demographic influences regarding inclusion in ECE. Embedded within inclusive pedagogical philosophy, the present descriptive study draws on a sample of 21 ECE teachers purposively selected from ECE settings in Mashonaland West educational province of…

Understanding water column and streambed thermal refugia for endangered mussels in the Delaware River

USGS Publications Warehouse

Briggs, Martin A.; Voytek, Emily B.; Day-Lewis, Frederick D.; Rosenberry, Donald O.; Lane, John W.

2013-01-01

Groundwater discharge locations along the upper Delaware River, both discrete bank seeps and diffuse streambed upwelling, may create thermal niche environments that benefit the endangered dwarf wedgemussel (Alasmidonta heterodon). We seek to identify whether discrete or diffuse groundwater inflow is the dominant control on refugia. Numerous springs and seeps were identified at all locations where dwarf wedgemussels still can be found. Infrared imagery and custom high spatial resolution fiber-optic distributed temperature sensors reveal complex thermal dynamics at one of the seeps with a relatively stable, cold groundwater plume extending along the streambed/water-column interface during mid-summer. This plume, primarily fed by a discrete bank seep, was shown through analytical and numerical heat-transport modeling to dominate temperature dynamics in the region of potential habitation by the adult dwarf wedgemussel.

Seasonal cycling of sulfur and iron in porewaters of a Delaware salt marsh

NASA Technical Reports Server (NTRS)

Luther, George W., III; Church, Thomas M.

1987-01-01

An extensive pore water data set has been gathered in the Great Marsh, Delaware over various seasons, salinities, and tides. The data all point to a complimentary redox cycle for sulfur and iron which operates seasonally and tidally. Surface oxidizing conditions prevail in summer, with more reducing conditions at depth during the winter. During the spring tides which flood the marsh, pyrite oxidation occurs releasing excess dissolved iron (II) and sulfate to the porewaters, and precipitating authigenic solid iron phases. The redox conditions in the porewaters of the upper zone during the summer is poised between mildly oxidizing and mildly reducing conditions as shown by pE calculations. This redox environment and intermediate iron-sulfur redox species may be important for the stimulation of plant growth (photosynthesis) and sustenance of a viable microbial community (heterotrophy and chemoautropy).

Predictors of Public Early Care and Education Use among Children of Low-Income Immigrants

PubMed Central

Johnson, Anna D.; Padilla, Christina; Votruba-Drzal, Elizabeth

2017-01-01

Little is known about predictors of publicly funded early care and education (ECE) use among low-income children of immigrants. Without this knowledge, it is difficult to effectively increase participation in these public programs, which promote school readiness but are underused by children of immigrants. Using nationally representative data from the Early Childhood Longitudinal Study -Birth Cohort (ECLS-B), this study attempts to identify pertinent family, child, maternal ECE preference, broader contextual, and immigrant specific characteristics predictive of ECE use among 4-year old children in a sample of low-income children of immigrants (N ≈ 1,050). Specifically, we estimate multinomial logistic regression models predicting type of ECE (Head Start, public pre-k, subsidized ECE, unsubsidized ECE, parental care) from these characteristics. Findings suggest that even in a low-income sample, correlates of disadvantage such as low maternal education and prior receipt of public benefits are important predictors of public ECE use, as are maternal preferences for certain features of care and supply-side factors such as ECE availability. Immigrant-specific factors such as English proficiency, citizenship status, availability of non-English speaking caregivers, and generosity of state policies toward immigrants emerged as particularly salient for explaining the public ECE selection patterns of low-income immigrants. Results point to future research areas and potential policy solutions aimed at increasing public ECE use for children who may stand to benefit the most. PMID:28966423

Dynamic linear modeling of monthly electricity demand in Japan: Time variation of electricity conservation effect

PubMed Central

Shiraki, Hiroto; Ashina, Shuichi

2018-01-01

After the severe nuclear disaster in Fukushima, which was triggered by the Great East Japan earthquake in March 2011, nuclear power plants in Japan were temporarily shut down for mandatory inspections. To prevent large-scale blackouts, the Japanese government requested companies and households to reduce electricity consumption in summer and winter. It is reported that the domestic electricity demand had a structural decrease because of the electricity conservation effect (ECE). However, quantitative analysis of the ECE is not sufficient, and especially time variation of the ECE remains unclear. Understanding the ECE is important because Japan’s NDC (nationally determined contribution) assumes the reduction of CO2 emissions through aggressive energy conservation. In this study, we develop a time series model of monthly electricity demand in Japan and estimate time variation of the ECE. Moreover, we evaluate the impact of electricity conservation on CO2 emissions from power plants. The dynamic linear model is used to separate the ECE from the effects of other irrelevant factors (e.g. air temperature, economic production, and electricity price). Our result clearly shows that consumers’ electricity conservation behavior after the earthquake was not temporary but became established as a habit. Between March 2011 and March 2016, the ECE on industrial electricity demand ranged from 3.9% to 5.4%, and the ECE on residential electricity demand ranged from 1.6% to 7.6%. The ECE on the total electricity demand was estimated at 3.2%–6.0%. We found a seasonal pattern that the residential ECE in summer is higher than that in winter. The emissions increase from the shutdown of nuclear power plants was mitigated by electricity conservation. The emissions reduction effect was estimated at 0.82 MtCO2–2.26 MtCO2 (−4.5% on average compared to the zero-ECE case). The time-varying ECE is necessary for predicting Japan’s electricity demand and CO2 emissions after the earthquake. PMID:29708988

Dynamic linear modeling of monthly electricity demand in Japan: Time variation of electricity conservation effect.

PubMed

Honjo, Keita; Shiraki, Hiroto; Ashina, Shuichi

2018-01-01

After the severe nuclear disaster in Fukushima, which was triggered by the Great East Japan earthquake in March 2011, nuclear power plants in Japan were temporarily shut down for mandatory inspections. To prevent large-scale blackouts, the Japanese government requested companies and households to reduce electricity consumption in summer and winter. It is reported that the domestic electricity demand had a structural decrease because of the electricity conservation effect (ECE). However, quantitative analysis of the ECE is not sufficient, and especially time variation of the ECE remains unclear. Understanding the ECE is important because Japan's NDC (nationally determined contribution) assumes the reduction of CO2 emissions through aggressive energy conservation. In this study, we develop a time series model of monthly electricity demand in Japan and estimate time variation of the ECE. Moreover, we evaluate the impact of electricity conservation on CO2 emissions from power plants. The dynamic linear model is used to separate the ECE from the effects of other irrelevant factors (e.g. air temperature, economic production, and electricity price). Our result clearly shows that consumers' electricity conservation behavior after the earthquake was not temporary but became established as a habit. Between March 2011 and March 2016, the ECE on industrial electricity demand ranged from 3.9% to 5.4%, and the ECE on residential electricity demand ranged from 1.6% to 7.6%. The ECE on the total electricity demand was estimated at 3.2%-6.0%. We found a seasonal pattern that the residential ECE in summer is higher than that in winter. The emissions increase from the shutdown of nuclear power plants was mitigated by electricity conservation. The emissions reduction effect was estimated at 0.82 MtCO2-2.26 MtCO2 (-4.5% on average compared to the zero-ECE case). The time-varying ECE is necessary for predicting Japan's electricity demand and CO2 emissions after the earthquake.

Fractures and stresses in Bone Spring sandstones. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warpinski, N.R.; Sattler, A.R.; Lorenz, J.C.

This project was a collaboration between Sandia National Laboratories and the Harvey E. Yates Company (Heyco), Roswell, NM, conducted under the auspices of Department of Energy`s Oil Recovery Technology Partnership. The project applied Sandia perspectives on the effects of natural fractures, stress, and sedimentology for the stimulation and production of low permeability gas reservoirs to low permeability oil reservoirs, such as those typified by the Bone Spring sandstones of the Delaware Basin, southeast New Mexico. This report details the results and analyses obtained in 1990 from core, logs, stress, and other data taken from three additional development wells. An overallmore » summary gives results from all five wells studied in this project in 1989--1990. Most of the results presented are believed to be new information for the Bone Spring sandstones.« less

Behavioural, ecological and evolutionary responses to extreme climatic events: challenges and directions.

PubMed

van de Pol, Martijn; Jenouvrier, Stéphanie; Cornelissen, Johannes H C; Visser, Marcel E

2017-06-19

More extreme climatic events (ECEs) are among the most prominent consequences of climate change. Despite a long-standing recognition of the importance of ECEs by paleo-ecologists and macro-evolutionary biologists, ECEs have only recently received a strong interest in the wider ecological and evolutionary community. However, as with many rapidly expanding fields, it lacks structure and cohesiveness, which strongly limits scientific progress. Furthermore, due to the descriptive and anecdotal nature of many ECE studies it is still unclear what the most relevant questions and long-term consequences are of ECEs. To improve synthesis, we first discuss ways to define ECEs that facilitate comparison among studies. We then argue that biologists should adhere to more rigorous attribution and mechanistic methods to assess ECE impacts. Subsequently, we discuss conceptual and methodological links with climatology and disturbance-, tipping point- and paleo-ecology. These research fields have close linkages with ECE research, but differ in the identity and/or the relative severity of environmental factors. By summarizing the contributions to this theme issue we draw parallels between behavioural, ecological and evolutionary ECE studies, and suggest that an overarching challenge is that most empirical and theoretical evidence points towards responses being highly idiosyncratic, and thus predictability being low. Finally, we suggest a roadmap based on the proposition that an increased focus on the mechanisms behind the biological response function will be crucial for increased understanding and predictability of the impacts of ECE.This article is part of the themed issue 'Behavioural, ecological and evolutionary responses to extreme climatic events'. © 2017 The Author(s).

Effectiveness of the Lunch is in the Bag program on communication between the parent, child and child-care provider around fruits, vegetables and whole grain foods: a group-randomized controlled trial

PubMed Central

Rashid, Tasnuva; Ranjit, Nalini; Byrd-Williams, Courtney; Chuang, Ru-Jye; Roberts-Gray, Cindy; Briley, Margaret; Sweitzer, Sara; Hoelscher, Deanna M.

2015-01-01

Objective To evaluate the effectiveness of the parent- and early care education (ECE) center-based Lunch is in the Bag program on communication between parent, child, and their ECE center providers around fruits, vegetables and whole grain foods (FVWG). Method A total of n=30 ECE center; 577 parent-child dyads participated in this group-randomized controlled trial conducted from 2011–2013 in Texas (n=15 ECE center, 327 dyads intervention group; n=15 ECE center, 250 dyads comparison group). Parent-child and parent-ECE center provider communication was measured using a parent-reported survey administered at baseline and end of the five-week intervention period. Multilevel linear regression analysis was used to compare the pre-to-post intervention changes in the parent-child and parent-ECE center provider communication scales. Significance was set at p<0.05. Results At baseline, parent-child and parent-ECE center provider communication scores were low. There was a significant increase post-intervention in the parent-ECE center provider communication around vegetables (Adjusted β = 0.78, 95%CI: 0.13, 1.43, p=0.002), and around fruit (Adjusted β = 0.62, 95%CI: 0.04, 0.20, p=0.04) among the parents in the intervention group as compared to those in the comparison group. There were no significant intervention effects on parent-child communication. Conclusion Lunch is in the Bag had significant positive effects on improving communication between the parents and ECE center providers around FVWG. PMID:26190371

Behavioural, ecological and evolutionary responses to extreme climatic events: challenges and directions

PubMed Central

2017-01-01

More extreme climatic events (ECEs) are among the most prominent consequences of climate change. Despite a long-standing recognition of the importance of ECEs by paleo-ecologists and macro-evolutionary biologists, ECEs have only recently received a strong interest in the wider ecological and evolutionary community. However, as with many rapidly expanding fields, it lacks structure and cohesiveness, which strongly limits scientific progress. Furthermore, due to the descriptive and anecdotal nature of many ECE studies it is still unclear what the most relevant questions and long-term consequences are of ECEs. To improve synthesis, we first discuss ways to define ECEs that facilitate comparison among studies. We then argue that biologists should adhere to more rigorous attribution and mechanistic methods to assess ECE impacts. Subsequently, we discuss conceptual and methodological links with climatology and disturbance-, tipping point- and paleo-ecology. These research fields have close linkages with ECE research, but differ in the identity and/or the relative severity of environmental factors. By summarizing the contributions to this theme issue we draw parallels between behavioural, ecological and evolutionary ECE studies, and suggest that an overarching challenge is that most empirical and theoretical evidence points towards responses being highly idiosyncratic, and thus predictability being low. Finally, we suggest a roadmap based on the proposition that an increased focus on the mechanisms behind the biological response function will be crucial for increased understanding and predictability of the impacts of ECE. This article is part of the themed issue ‘Behavioural, ecological and evolutionary responses to extreme climatic events’. PMID:28483865

An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tempel, W.; Wu, H.; Dombrovsky, L.

2010-08-17

A recent survey of protein expression patterns in patients with Alzheimer's disease (AD) has identified ece2 (chromosome: 3; Locations: 3q27.1) as the most significantly downregulated gene within the tested group. ece2 encodes endothelin-converting enzyme ECE2, a metalloprotease with a role in neuropeptide processing. Deficiency in the highly homologous ECE1 has earlier been linked to increased levels of AD-related {beta}-amyloid peptide in mice, consistent with a role for ECE in the degradation of that peptide. Initially, ECE2 was presumed to resemble ECE1, in that it comprises a single transmembrane region of {approx}20 residues flanked by a small amino-terminal cytosolic segment andmore » a carboxy-terminal lumenar peptidase domain. The carboxy-terminal domain has significant sequence similarity to both neutral endopeptidase, for which an X-ray structure has been determined, and Kell blood group protein. After their initial discovery, multiple isoforms of ECE1 and ECE2 were discovered, generated by alternative splicing of multiple exons. The originally described ece2 transcript, RefSeq NM{_}174046, contains the amino-terminal cytosolic portion followed by the transmembrane region and peptidase domain (Fig. 1, isoform B). Another ece2 transcript, available from the Mammalian Gene Collection under MGC2408 (Fig. 1, isoform C), RefSeq accession NM{_}032331, is predicted to be translated into a 255 residue peptide with low but detectable sequence similarity to known S-adenosyl-L-methionine (SAM)-dependent methyltransferases (SAM-MTs), such as the hypothetical protein TT1324 from Thermus thermophilis, PDB code 2GS9, which shares 30% amino acid sequence identity with ECE2 over 138 residues of the sequence. Intriguingly, another 'elongated' ece2 transcript (Fig. 1, isoform A) (RefSeq NM{_}014693) contains an amino-terminal portion of the putative SAM-MT domain, the transmembrane domain, and the protease domain. This suggests the possibility for coexistence of the putative SAM-MT and protease domains in a single polypeptide and their transmembrane interplay. Although sequence conservation across the SAM-MT family is weak, the structural fold is highly conserved. The most conserved part of this fold is the SAM-binding subdomain, which is shared between MGC2408 and hypothetical protein TT1324. Typically, the SAM-binding subdomain is flanked by a variable Nterminal extension and, at the C-terminus, by a substrate- binding subdomain, which varies enormously in size but preserves a conserved topology with three antiparallel b-strands. The 'elongated' transcript of ece2 lacks this substrate-binding subdomain. To test the hypothesis that the 255 residue ece2 gene product MGC2408 represents a complete SAM-MT fold, we have determined a crystal structure of this protein in the presence of SAH.« less

Patterns of failure after postoperative radiotherapy for incompletely resected (R1) non-small cell lung cancer: implications for radiation target volume design.

PubMed

Olszyna-Serementa, Marta; Socha, Joanna; Wierzchowski, Marek; Kępka, Lucyna

2013-05-01

Overall survival (OS) and pattern of failure in R1-resected non-small cell lung cancer (NSCLC) patients treated with 3D-planned postoperative radiotherapy (PORT) was retrospectively evaluated. The outcomes and patterns of failure in patients with (+) and without (-) extracapsular nodal extension (ECE) were compared and analyzed with respect to the radiation target volume design. Eighty R1-resected (37 ECE+ and 43 ECE-) patients received PORT (60Gy, 2Gy daily) between 2002 and 2011. Patients with N2 disease received limited elective nodal irradiation (ENI); for pN0-1 disease the use of ENI was optional. Among ECE- (extranodal-R1) patients there were 35 pN0-1 and eight pN2 cases; in pN0-1 patients, patterns of failure and outcomes were analyzed with respect to the use of ENI. Loco-regional failure (LRF) was defined as in-field relapse; isolated nodal failure (INF) was defined as out-of-field regional nodal recurrence occurring without LRF, irrespective of distant metastases. The actuarial 3-year OS rate was 36.3% (median: 30 months). Three-year OS rates in the ECE- and ECE+ group were 40.4% and 31.4%, with median OS of 31 and 24 months, respectively (p=0.43). In multivariate analysis, the presence of ECE was correlated with OS (HR=3.02; 95% CI: 1.00-9.16; p=0.05). Three-year cumulative incidence of LRF (CILRF) was 14.5% and 15.5% in the ECE- and ECE+ groups, respectively (p=0.98). Three-year cumulative incidence of INF (CIINF) was 14.1% in the ECE- group and 11.1% in the ECE+ group (p=0.76). For pN0-1 patients treated with and without ENI (13 and 22 patients) 3-year CILRF rates were 7.7% and 20.8%, respectively (p=0.20); 3-year CIINF rates were 9.1% and 16.3%, respectively (p=0.65). PORT resulted in a relatively good survival of R1-resected NSCLC patients. Relatively high incidence of INF was found in both ECE+ and ECE- patients. For ECE+ patients, treated with limited ENI, distant failure remains a major concern, so the design of ENI fields seems of lesser importance. Omission of ENI in pN0-1 (extranodal-R1) patients resulted in an unacceptably high incidence of INF. We postulate the use of some form of ENI in this setting. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Role of Protein Kinase C in Endothelin Converting Enzyme-1 trafficking and shedding from endothelial cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuruppu, Sanjaya, E-mail: Sanjaya.Kuruppu@med.monash.edu.au; Tochon-Danguy, Natalie; Ian Smith, A.

2010-07-23

Research highlights: {yields} PKC activation increases the trafficking of ECE-1 to the cell surface. {yields} This in turn leads to an increase in the amount of ECE-1 shed. {yields} Only the catalytically active C-terminal region is shed from the cell surface. -- Abstract: This study aimed to determine the consequences of Protein Kinase C (PKC) mediated Endothelin Converting Enzyme-1 (ECE-1) phosphorylation and its relationship to ECE-1 expression and shedding. The proteins on the surface of EA.hy926 cells were labelled with EZ-Link NHS-SS-Biotin both prior to (control) and following stimulation by 2 {mu}M phorbol 12-myristate 13-acetate (PMA) which activates PKC. Themore » biotinylated proteins were isolated using neutravidin beads, resolved by gel electrophoresis and analysed by western blotting using anti-ECE-1 antibodies. Significant increase in ECE-1 expression at the cell surface was observed following stimulation by PMA, compared to unstimulated control cells (170 {+-} 32.3% of control, n = 5). The ECE-1 activity (expressed as {mu}M substrate cleaved/min) was determined by monitoring the cleavage of a quenched fluorescent substrate. The specificity of cleavage was confirmed using the ECE-1 inhibitor (CGS35066). The stimulation of cells by PMA (1 {mu}M, 6 h) significantly increased the ECE-1 activity (0.28 {+-} 0.02; n = 3) compared to the control (0.07 {+-} 0.02; n = 3). This increase was prevented by prior incubation with the PKC inhibitor bisindolymaleimide (BIM; 2 {mu}M for 1 h; 0.10 {+-} 0.01; n = 3). Treatment with PMA also increased the activity of ECE-1 in the media (0.18 {+-} 0.01; n = 3) compared to control (0.08 {+-} 0.01; n = 3). In addition, this study confirmed by western immunoblotting that only the extracellular region of ECE-1 is released from the cell surface. These data indicate for the first time that PKC activation induces the trafficking and shedding of ECE to and from the cell surface, respectively.« less

Elsholtzia ciliata (Thunb.) Hylander attenuates renal inflammation and interstitial fibrosis via regulation of TGF-ß and Smad3 expression on unilateral ureteral obstruction rat model.

PubMed

Kim, Tae-Won; Kim, Young-Jung; Seo, Chang-Seob; Kim, Hyun-Tae; Park, Se-Ra; Lee, Mee-Young; Jung, Ju-Young

2016-04-15

Renal interstitial fibrosis is characterized by excessive accumulation of extracellular matrix, which leads to end-stage renal failure. The aim of this study was to explore the effect of Elsholtzia ciliata (Thunb.) Hylander ethanol extract (ECE) on renal interstitial fibrosis induced by unilateral ureteral obstruction (UUO). After quantitative analysis of ECE using the high performance liquid chromatography-photodiode array (HPLC-PDA) method, an in vitro study was performed to assess the anti-inflammatory and anti-fibrotic effects of ECE, using lipopolysaccharide (LPS) and transforming growth factor-ß (TGF-ß), respectively. For in vivo study, all male Sprague Dawley (SD) rats (n=10/group), except for those in the control group, underwent UUO. The rats were orally treated with water (control), captopril (positive control, 200 mg/kg), and ECE (300 and 500 mg/kg) for 14 days. In ECE, luteolin and rosmarinic acid were relatively abundant among the other flavonoids and phenolic acids. ECE treatment ameliorated LPS-induced overexpression of nuclear factor-κB, tumor necrosis factor (TNF-α), and interleukin-6 and improved oxidative stress in RAW 264.7 cells. Furthermore, ECE treatment suppressed TGF-ß-induced α-smooth muscle actin and matrix metalloproteinase 9 expression in human renal mesangial cells. In the UUO model, 14 consecutive days of ECE treatment improved UUO-induced renal damage and attenuated histopathological alterations and interstitial fibrosis. Moreover, the renal expression of TNF-α, TGF-ß, and Smad 3 were inhibited by ECE treatment. Taken together, the effects of ECE may be mediated by blocking the activation of TGF-ß and inflammatory cytokines, leading subsequently to degradation of the ECM accumulation pathway. Based on these findings, ECE might serve as an improved treatment strategy for renal fibrotic disease. Copyright © 2016 Elsevier GmbH. All rights reserved.

Effectiveness of the Lunch is in the Bag program on communication between the parent, child and child-care provider around fruits, vegetables and whole grain foods: A group-randomized controlled trial.

PubMed

Sharma, Shreela V; Rashid, Tasnuva; Ranjit, Nalini; Byrd-Williams, Courtney; Chuang, Ru-Jye; Roberts-Gray, Cynthia; Briley, Margaret; Sweitzer, Sara; Hoelscher, Deanna M

2015-12-01

To evaluate the effectiveness of the parent- and early care education (ECE) center-based Lunch is in the Bag program on communication between parent, child, and their ECE center providers around fruits, vegetables and whole grain foods (FVWG). A total of n=30 ECE center; 577 parent-child dyads participated in this group-randomized controlled trial conducted from 2011 to 2013 in Texas (n=15 ECE center, 327 dyads intervention group; n=15 ECE center, 250 dyads comparison group). Parent-child and parent-ECE center provider communication was measured using a parent-reported survey administered at baseline and end of the five-week intervention period. Multilevel linear regression analysis was used to compare the pre-to-post intervention changes in the parent-child and parent-ECE center provider communication scales. Significance was set at p<0.05. At baseline, parent-child and parent-ECE center provider communication scores were low. There was a significant increase post-intervention in the parent-ECE center provider communication around vegetables (Adjusted β=0.78, 95%CI: 0.13, 1.43, p=0.002), and around fruit (Adjusted β=0.62, 95%CI: 0.04, 0.20, p=0.04) among the parents in the intervention group as compared to those in the comparison group. There were no significant intervention effects on parent-child communication. Lunch is in the Bag had significant positive effects on improving communication between the parents and ECE center providers around FVWG. Copyright © 2015 Elsevier Inc. All rights reserved.

Upgrades and Real Time Ntm Control Application of the Ece Radiometer on Asdex Upgrade

NASA Astrophysics Data System (ADS)

Hicks, N. K.; Suttrop, W.; Behler, K.; Giannone, L.; Manini, A.; Maraschek, M.; Raupp, G.; Reich, M.; Sips, A. C. C.; Stober, J.; Treutterer, W.; ASDEX Upgrade Team; Cirant, S.

2009-04-01

The 60-channel electron cyclotron emission (ECE) radiometer diagnostic on the ASDEX Upgrade tokamak is presently being upgraded to include a 1 MHz sampling rate data acquisition system. This expanded capability allows electron temperature measurements up to 500 kHz (anti-aliasing filter cut-off) with spatial resolution ~1 cm, and will thus provide measurement of plasma phenomena on the MHD timescale, such as neoclassical tearing modes (NTMs). The upgraded and existing systems may be run in parallel for comparison, and some of the first plasma measurements using the two systems together are presented. A particular planned application of the upgraded radiometer is integration into a real-time NTM stabilization loop using targeted deposition of electron cyclotron resonance heating (ECRH). For this loop, it is necessary to determine the locations of the NTM and ECRH deposition using ECE measurements. As the magnetic island of the NTM repeatedly rotates through the ECE line of sight, electron temperature fluctuations at the NTM frequency are observed. The magnetic perturbation caused by the NTM is independently measured using Mirnov coils, and a correlation profile between these magnetic measurements and the ECE data is constructed. The phase difference between ECE oscillations on opposite sides of the island manifests as a zero-crossing of the correlation profile, which determines the NTM location in ECE channel space. To determine the location of ECRH power deposition, the power from a given gyrotron may be modulated at a particular frequency. Correlation analysis of this modulated signal and the ECE data identifies a particular ECE channel associated with the deposition of that gyrotron. Real time equilibrium reconstruction allows the ECE channels to be translated into flux surface and spatial coordinates for use in the feedback loop.

Update on the status of the ITER ECE diagnostic design

NASA Astrophysics Data System (ADS)

Taylor, G.; Austin, M. E.; Basile, A.; Beno, J. H.; Danani, S.; Feder, R.; Houshmandyar, S.; Hubbard, A. E.; Johnson, D. W.; Khodak, A.; Kumar, R.; Kumar, S.; Ouroua, A.; Padasalagi, S. B.; Pandya, H. K. B.; Phillips, P. E.; Rowan, W. L.; Stillerman, J.; Thomas, S.; Udintsev, V. S.; Vayakis, G.; Walsh, M.; Weeks, D.

2017-07-01

Considerable progress has been made on the design of the ITER electron cyclotron emission (ECE) diagnostic over the past two years. Radial and oblique views are still included in the design in order to measure distortions in the electron momentum distribution, but the oblique view has been redirected to reduce stray millimeter radiation from the electron cyclotron heating system. A major challenge has been designing the 1000 K calibration sources and remotely activated mirrors located in the ECE diagnostic shield module (DSM) in the equatorial port plug #09. These critical systems are being modeled and prototypes are being developed. Providing adequate neutron shielding in the DSM while allowing sufficient space for optical components is also a significant challenge. Four 45-meter long low-loss transmission lines transport the 70-1000 GHz ECE from the DSM to the ECE instrumentation room. Prototype transmission lines are being tested, as are the polarization splitter modules that separate O-mode and X-mode polarized ECE. A highly integrated prototype 200-300 GHz radiometer is being tested on the DIII-D tokamak in the USA. Design activities also include integration of ECE signals into the ITER plasma control system and determining the hardware and software architecture needed to control and calibrate the ECE instruments.

Patterns of care and outcomes of adjuvant therapy for high-risk head and neck cancer after surgery.

PubMed

Osborn, Virginia Wedell; Givi, Babak; Rineer, Justin; Roden, Dylan; Sheth, Niki; Lederman, Ariel; Katsoulakis, Evangelia; Hu, Kenneth; Schreiber, David

2018-06-01

Postoperative chemoradiotherapy (CRT) is considered standard of care in patients with locally advanced head and neck cancer with positive margins and/or extracapsular extension (ECE). The National Cancer Data Base (NCDB) was queried to identify patients with squamous cell carcinoma of the head and neck with stages III to IVB disease or with positive margins and/or ECE diagnosed between 2004 and 2012 receiving postoperative radiotherapy (RT). Using univariable and multivariable logistic and Cox regression, we assessed for predictors of CRT use and covariables impacting overall survival (OS), including in a propensity-matched subset. Of 12 224 patients, 67.1% with positive margins and/or ECE received CRT as well as 54.0% without positive margins and/or ECE. The 5-year OS was 61.6% for RT alone versus 67.4% for CRT. In the propensity-matched cohort, OS benefit persisted with CRT, including in a subset with positive margins and/or ECE but not without. Postoperative CRT seems underutilized with positive margins and/or ECE and overutilized without positive margins and/or ECE. The CRT was associated with improved OS but the benefit persisted only in the subset with positive margins and/or ECE. © 2018 Wiley Periodicals, Inc.

Land- and sea-surface impacts on local coastal breezes

NASA Astrophysics Data System (ADS)

Veron, D. E.; Hughes, C.; Gilchrist, J.; Lodise, J.; Goldman, W.

2014-12-01

The state of Delaware has seen significant increases in population along the coastline in the past three decades. With this increase in population have come changes to the land surface, as forest and farmland has been converted to residential and commercial purposes, causing changes in the surface roughness, temperature, and land-atmosphere fluxes. There is also a semi-permanent upwelling center in the spring and summer outside the Delaware Bay mouth that significantly changes the structure of the sea surface temperature both inside and outside the Bay. Through a series of high resolution modeling and observational studies, we have determined that in cases of strong synoptic forcing, the impact of the land-surface on the boundary layer properties can be advected offshore, creating a false coastline and modifying the location and timing of the sea breeze circulation. In cases of weak synoptic forcing, the influence of the upwelling and the tidal circulation of the Delaware Bay waters can greatly change the location, strength, and penetration of the sea breeze. Understanding the importance of local variability in the surface-atmosphere interactions on the sea breeze can lead to improved prediction of sea breeze onset, penetration, and duration which is important for monitoring air quality and developing offshore wind power production.

Human uterine cervical epithelial cells grown on permeable support--a new model for the study of differentiation.

PubMed

Gorodeski, G I; Romero, M F; Hopfer, U; Rorke, E; Utian, W H; Eckert, R L

1994-04-01

The purpose of the present study was to establish culture conditions for human uterine cervical epithelial cells on permeable support and to determine how it affects cervical cell differentiation. Human ectocervical epithelial cells (hECE), HPV-16 immortalized hECE cells (ECE16-1) and Caski cells were grown on collagen-coated filters. Culture conditions, density of cells in culture and expression of epithelial and cervical-cell phenotypic markers were determined and compared in cells grown on filter and on solid support. Compared with the latter, cultures on filter had a higher cell density, hECE cells stratified to 5-12 cell layers compared to 1-3 on solid support, and cells of all three types expressed intercellular tight junctions. The cytokeratin profiles revealed differences between the three cell types as well as differences within the same cell species when grown on filter, compared to solid support. Of particular importance was the finding of a higher expression of K-13 in hECE grown on filter compared to solid support; K-13 is a marker of ectocervical cell differentiation. The cytokeratin profiles of the cultured hECE, ECE16-1 and Caski cells resembled those of ectocervical, squamous metaplastic and endocervical epithelia, respectively. hECE and ECE16-1 expressed involucrin protein, the level of which in both was higher in cells grown on filter compared to solid support. Polarization of the cultures was determined by morphology (stratification of hECE cells, expression of pseudomicrovilli in the apical cell membrane), selective apical vs. basolateral secretion of [35S]methionine- and [35S]cysteine-, [3H]fucose- and [14C]glucosamine-labeled molecules, and positive short-circuit current (Isc) under voltage-clamp conditions. Confluency of the cultures was determined by measuring transepithelial unidirectional fluxes of inert molecules with different molecular weights (MWs) through the paracellular pathway, and by measuring transepithelial conductance. The results indicated transepithelial permeability of 7-22.10(-6) cm.sec-1, which was 5-100 fold smaller compared to blank inserts, with a cut-off MW of 40-70 kDa for hECE and Caski cells. Transepithelial conductance ranged 18.5 to 51.5 mS.cm-2, indicating a leaky but confluent epithelia. Collectively the results indicate the epithelial nature of the cells and their improved differentiation when grown on filter support; hECE is a model for ectocervical epithelium while ECE16-1 and Caski express phenotypic characteristics of squamous metaplastic cervical epithelium and endocervical epithelium respectively.

Pre-school nutrition-related behaviours at home and early childhood education services: findings from the Growing Up in New Zealand longitudinal study.

PubMed

Gerritsen, Sarah; Anderson, Sarah E; Morton, Susan Mb; Wall, Clare R

2018-05-01

Pre-school nutrition-related behaviours influence diet and development of lifelong eating habits. We examined the prevalence and congruence of recommended nutrition-related behaviours (RNB) in home and early childhood education (ECE) services, exploring differences by child and ECE characteristics. Telephone interviews with mothers. Online survey of ECE managers/head teachers. New Zealand. Children (n 1181) aged 45 months in the Growing Up in New Zealand longitudinal study. A mean 5·3 of 8 RNB were followed at home, with statistical differences by gender and ethnic group, but not socio-economic position. ECE services followed a mean 4·8 of 8 RNB, with differences by type of service and health-promotion programme participation. No congruence between adherence at home and in ECE services was found; half of children with high adherence at home attended a service with low adherence. A greater proportion of children in deprived communities attended a service with high adherence, compared with children living in the least deprived communities (20 and 12 %, respectively). Children, across all socio-economic positions, may not experience RNB at home. ECE settings provide an opportunity to improve or support behaviours learned at home. Targeting of health-promotion programmes in high-deprivation areas has resulted in higher adherence to RNB at these ECE services. The lack of congruence between home and ECE behaviours suggests health-promotion messages may not be effectively communicated to parents/family. Greater support is required across the ECE sector to adhere to RNB and promote wider change that can reach into homes.

A potent feed preservative candidate produced by Calcarisporium sp., an endophyte residing in stargrass (Cynodon dactylon).

PubMed

Ji, L L; Song, Y C; Tan, R X

2004-01-01

The cultures of an endophytic fungus Calcarisporium sp. were screened for inhibitors on the growth of feed-associated moulds and on the aflatoxin biosynthesis to find a safe and effective feed preservative. Eight test fungi were isolated from the spoiled poultry feed. The endophytic fungus Calcarisporium sp. was separated from the Chinese coastal grass Cynodon dactylon. The antifungal action concerning the endophytic culture extract (ECE) was performed with propionic acid (PPA) as the corresponding reference. The ECE had a similar antifungal efficacy to PPA in a concentration-dependent manner. The susceptibility order of the ECE to the test fungi was found to be Fusarium sp. > Aspergillus spp. > Penicillium spp. Furthermore, the application of the ECE in pelleted-layer duck feed as a preservative was carried out at a humidity of 10, 15 and 20%. It has been discerned that mould growth and aflatoxin biosynthesis could be co-inhibited almost completely by ECE at concentrations higher than 1.0% (w/w). The LD50 of the ECE on mice was shown to be higher than 28 g kg-1. The ECE can be selected as an inhibitor to preserve poultry feed on inhibiting the growth of mould and aflatoxin biosynthesis during feed storage. The ECE may be an effective and biosafe antifungal ingredient for poultry feed and holds a potential market prospect in feed industry.

Does aggregate school-wide achievement mediate fifth grade outcomes for former early childhood education participants?

PubMed

Curenton, Stephanie M; Dong, Nianbo; Shen, Xiangjin

2015-07-01

This study used a multilevel mediation model to test the theory that former early childhood education (ECE) attendees' 5th grade achievement is mediated by the aggregate school-wide achievement of their elementary school. Aggregate school-wide achievement was defined as the percentage of 5th graders in a school who were at/above academic proficiency in reading or math. Research questions were: (a) Do ECE program participants have better achievement at 5th grade compared with their matched peers who did not participate in an ECE program?; and (b) Is the association between ECE attendance and 5th grade academic performance mediated by school-wide achievement? Results indicated that children who attended prekindergarten (pre-K) and child care outperformed their matched peers who had not attended ECE programs; conversely, those children who did not attend ECE actually outperformed their Head Start counterparts. Mediation analyses indicated that aggregate school-wide achievement at 5th grade partially mediated the association between former ECE attendance and 5th grade performance; however, these mediated effects were small. Overall, the size of the total effects of ECE and the 5th grade academic outcomes were consistent with prior studies. This research confirms the long-term effects of pre-K and child care until 5th grade. (c) 2015 APA, all rights reserved).

Nitric oxide inhibits the production of soluble endothelin converting enzyme-1.

PubMed

Kuruppu, Sanjaya; Rajapakse, Niwanthi W; Dunstan, Rhys A; Smith, A Ian

2014-11-01

This study examined the effect of nitric oxide on the production of soluble ECE-1. Activity of ECE-1 in media was measured using a quenched fluorescent substrate assay, and expressed as a percentage of control. Endothelial cells were incubated with the nitric oxide donor Diethylenetriamine NONOate (DETA; 250-800 µM), NOS substrate L-Arg (200-1,000 µM), a L-Arg transport inhibitor (L-Lys; 10 µM) and NOS inhibitors (L-Gln and N5-[imino(nitroamino)methyl]-L-ornithine, methyl ester, monohydrochloride (L-NAME); 10-100 µM). The effect of L-Arg (1,000 µM) was also tested in the presence of L-Lys (10 µM), L-Gln (100 µM) and L-NAME (10-100 µM). Ultracentrifugation (100,000×g, 4 °C, 1 h) completely removed ECE-1 activity from the supernatant. In addition, fractionation of concentrated media on a sucrose density gradient indicated that ECE-1 activity was localised to the mid portion of the gradient, thus suggesting the possible role of exosomes in ECE-1 release. Production of soluble ECE-1 by Ea.hy926 cells was inhibited significantly (P < 0.05, unpaired t test, n = 4) in the presence of DETA (75.31 ± 3.59; 800 µM) and L-Arg (60.97 ± 9.22; 1,000 µM). L-Arg-mediated reduction in the release of soluble ECE-1 was blocked by the inhibition of NOS using L-NAME (100 µM; 99.19 ± 0.58) and L-Gln (100 µM; 104.41 ± 0.65). In addition, the presence of L-Lys (10 µM) significantly blocked the L-Arg (1,000 µM)-induced reduction in soluble ECE-1 levels (122.38 ± 13.16). These treatments had no effect on the expression of ECE-1 on the cell surface. Our data provide evidence that NO can inhibit the production of soluble ECE-1 by endothelial cells.

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons.

PubMed

Zhao, Peishen; Canals, Meritxell; Murphy, Jane E; Klingler, Diana; Eriksson, Emily M; Pelayo, Juan-Carlos; Hardt, Markus; Bunnett, Nigel W; Poole, Daniel P

2013-09-06

Somatostatin (SST) 14 and SST 28 activate somatostatin 2A receptors (SSTR2A) on enteric neurons to control gut functions. SST analogs are treatments of neuroendocrine and bleeding disorders, cancer, and diarrhea, with gastrointestinal side effects of constipation, abdominal pain, and nausea. How endogenous agonists and drugs differentially regulate neuronal SSTR2A is unexplored. We evaluated SSTR2A trafficking in murine myenteric neurons and neuroendocrine AtT-20 cells by microscopy and determined whether agonist degradation by endosomal endothelin-converting enzyme 1 (ECE-1) controls SSTR2A trafficking and association with β-arrestins, key regulators of receptors. SST-14, SST-28, and peptide analogs (octreotide, lanreotide, and vapreotide) stimulated clathrin- and dynamin-mediated internalization of SSTR2A, which colocalized with ECE-1 in endosomes and the Golgi. After incubation with SST-14, SSTR2A recycled to the plasma membrane, which required active ECE-1 and an intact Golgi. SSTR2A activated by SST-28, octreotide, lanreotide, or vapreotide was retained within the Golgi and did not recycle. Although ECE-1 rapidly degraded SST-14, SST-28 was resistant to degradation, and ECE-1 did not degrade SST analogs. SST-14 and SST-28 induced transient interactions between SSTR2A and β-arrestins that were stabilized by an ECE-1 inhibitor. Octreotide induced sustained SSTR2A/β-arrestin interactions that were not regulated by ECE-1. Thus, when activated by SST-14, SSTR2A internalizes and recycles via the Golgi, which requires ECE-1 degradation of SST-14 and receptor dissociation from β-arrestins. After activation by ECE-1-resistant SST-28 and analogs, SSTR2A remains in endosomes because of sustained β-arrestin interactions. Therapeutic SST analogs are ECE-1-resistant and retain SSTR2A in endosomes, which may explain their long-lasting actions.

Agonist-biased Trafficking of Somatostatin Receptor 2A in Enteric Neurons*

PubMed Central

Zhao, Peishen; Canals, Meritxell; Murphy, Jane E.; Klingler, Diana; Eriksson, Emily M.; Pelayo, Juan-Carlos; Hardt, Markus; Bunnett, Nigel W.; Poole, Daniel P.

2013-01-01

Somatostatin (SST) 14 and SST 28 activate somatostatin 2A receptors (SSTR2A) on enteric neurons to control gut functions. SST analogs are treatments of neuroendocrine and bleeding disorders, cancer, and diarrhea, with gastrointestinal side effects of constipation, abdominal pain, and nausea. How endogenous agonists and drugs differentially regulate neuronal SSTR2A is unexplored. We evaluated SSTR2A trafficking in murine myenteric neurons and neuroendocrine AtT-20 cells by microscopy and determined whether agonist degradation by endosomal endothelin-converting enzyme 1 (ECE-1) controls SSTR2A trafficking and association with β-arrestins, key regulators of receptors. SST-14, SST-28, and peptide analogs (octreotide, lanreotide, and vapreotide) stimulated clathrin- and dynamin-mediated internalization of SSTR2A, which colocalized with ECE-1 in endosomes and the Golgi. After incubation with SST-14, SSTR2A recycled to the plasma membrane, which required active ECE-1 and an intact Golgi. SSTR2A activated by SST-28, octreotide, lanreotide, or vapreotide was retained within the Golgi and did not recycle. Although ECE-1 rapidly degraded SST-14, SST-28 was resistant to degradation, and ECE-1 did not degrade SST analogs. SST-14 and SST-28 induced transient interactions between SSTR2A and β-arrestins that were stabilized by an ECE-1 inhibitor. Octreotide induced sustained SSTR2A/β-arrestin interactions that were not regulated by ECE-1. Thus, when activated by SST-14, SSTR2A internalizes and recycles via the Golgi, which requires ECE-1 degradation of SST-14 and receptor dissociation from β-arrestins. After activation by ECE-1-resistant SST-28 and analogs, SSTR2A remains in endosomes because of sustained β-arrestin interactions. Therapeutic SST analogs are ECE-1-resistant and retain SSTR2A in endosomes, which may explain their long-lasting actions. PMID:23913690

Major amyloid-β-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex.

PubMed

Pacheco-Quinto, Javier; Eckman, Christopher B; Eckman, Elizabeth A

2016-12-01

Impaired clearance of amyloid-β peptide (Aβ) has been postulated to significantly contribute to the amyloid accumulation typical of Alzheimer's disease. Among the enzymes known to degrade Aβ in vivo are endothelin-converting enzyme (ECE)-1, ECE-2, and neprilysin (NEP), and evidence suggests that they regulate independent pools of Aβ that may be functionally significant. To better understand the differential regulation of Aβ concentration by its physiological degrading enzymes, we characterized the cell and region-specific expression pattern of ECE-1, ECE-2, and NEP by in situ hybridization and immunohistochemistry in brain areas relevant to Alzheimer's disease. In contrast to the broader distribution of ECE-1, ECE-2 and NEP were found enriched in GABAergic neurons. ECE-2 was majorly expressed by somatostatin-expressing interneurons and was active in isolated synaptosomes. NEP messenger RNA was found mainly in parvalbumin-expressing interneurons, with NEP protein localized to perisomatic parvalbuminergic synapses. The identification of somatostatinergic and parvalbuminergic synapses as hubs for Aβ degradation is consistent with the possibility that Aβ may have a physiological function related to the regulation of inhibitory signaling. Copyright © 2016 Elsevier Inc. All rights reserved.

Initial Data of Digital Correlation ECE with a Giga Hertz Sampling Digitizer

NASA Astrophysics Data System (ADS)

Tsuchiya, Hayato; Inagaki, Shigeru; Tokuzawa, Tokihiko; Nagayama, Yoshio

2015-03-01

The proposed Digital Correlation ECE (DCECE) technique is applied in Large Helical Device. DCECE is realized by the use of the Giga Hertz Sampling Digitizer. The waveform of intermediate frequency band of ECE, whose frequency is several giga hertz, can be discretized and saved directly. The discretized IF data can be used for the analysis of correlation ECE with arbitrary parameter of spatial resolution and temporal resolution. In this paper, the characteristic of DCECE and initial Data in LHD is introduced.

Combining Phylogenetic and Syntenic Analyses for Understanding the Evolution of TCP ECE Genes in Eudicots

PubMed Central

Citerne, Hélène L.; Le Guilloux, Martine; Sannier, Julie; Nadot, Sophie; Damerval, Catherine

2013-01-01

TCP ECE genes encode transcription factors which have received much attention for their repeated recruitment in the control of floral symmetry in core eudicots, and more recently in monocots. Major duplications of TCP ECE genes have been described in core eudicots, but the evolutionary history of this gene family is unknown in basal eudicots. Reconstructing the phylogeny of ECE genes in basal eudicots will help set a framework for understanding the functional evolution of these genes. TCP ECE genes were sequenced in all major lineages of basal eudicots and Gunnera which belongs to the sister clade to all other core eudicots. We show that in these lineages they have a complex evolutionary history with repeated duplications. We estimate the timing of the two major duplications already identified in the core eudicots within a timeframe before the divergence of Gunnera and after the divergence of Proteales. We also use a synteny-based approach to examine the extent to which the expansion of TCP ECE genes in diverse eudicot lineages may be due to genome-wide duplications. The three major core-eudicot specific clades share a number of collinear genes, and their common evolutionary history may have originated at the γ event. Genomic comparisons in Arabidopsis thaliana and Solanum lycopersicum highlight their separate polyploid origin, with syntenic fragments with and without TCP ECE genes showing differential gene loss and genomic rearrangements. Comparison between recently available genomes from two basal eudicots Aquilegia coerulea and Nelumbo nucifera suggests that the two TCP ECE paralogs in these species are also derived from large-scale duplications. TCP ECE loci from basal eudicots share many features with the three main core eudicot loci, and allow us to infer the makeup of the ancestral eudicot locus. PMID:24019982

Do early care and education services improve language development for maltreated children? Evidence from a national child welfare sample.

PubMed

Merritt, Darcey H; Klein, Sacha

2015-01-01

Young children under 6 years old are over-represented in the U.S. child welfare system (CWS). Due to their exposure to early deprivation and trauma, they are also highly vulnerable to developmental problems, including language delays. High quality early care and education (ECE) programs (e.g. preschool, Head Start) can improve children's development and so policymakers have begun calling for increased enrollment of CWS-supervised children in these programs. However, it is not a given that ECE will benefit all children who experience maltreatment. Some types of maltreatment may result in trauma-related learning and behavior challenges or developmental deficits that cause children to respond to ECE settings differently. The current study uses data from a nationally representative survey of children in the U.S. child welfare system, the National Survey of Child and Adolescent Well-Being II, to assess whether young CWS-supervised children (N=1,652) who were enrolled in ECE had better language development outcomes 18 months later than those not enrolled in ECE. We also explore whether the type of maltreatment that brought children to the CWS' attention moderates the relationship between ECE and children's language development. After controlling for children's initial scores on the Preschool Language Scale (PLS-3), type(s) of maltreatment experienced, and child and caregiver demographics, we found that ECE participation predicted better PLS-3 scores at follow-up, with a positive interaction between ECE participation and supervisory neglect. ECE seems to be beneficial for CWS-involved children's early language development, especially for children referred to the CWS because they lack appropriate parent supervision at home. Copyright © 2014 Elsevier Ltd. All rights reserved.

Endothelin-converting enzyme 2 differentially regulates opioid receptor activity

PubMed Central

Gupta, A; Fujita, W; Gomes, I; Bobeck, E; Devi, L A

2015-01-01

BACKGROUND AND PURPOSE Opioid receptor function is modulated by post-activation events such as receptor endocytosis, recycling and/or degradation. While it is generally understood that the peptide ligand gets co-endocytosed with the receptor, relatively few studies have investigated the role of the endocytosed peptide and peptide processing enzymes in regulating receptor function. In this study, we focused on endothelin-converting enzyme 2 (ECE2), a member of the neprilysin family of metallopeptidases that exhibits an acidic pH optimum, localizes to an intracellular compartment and selectively processes neuropeptides including opioid peptides in vitro, and examined its role in modulating μ receptor recycling and resensitization. EXPERIMENTAL APPROACH The effect of ECE2 inhibition on hydrolysis of the endocytosed peptide was examined using thin-layer chromatography and on μ opioid receptor trafficking using either elisa or microscopy. The effect of ECE2 inhibition on receptor signalling was measured using a cAMP assay and, in vivo, on antinociception induced by intrathecally administered opioids by the tail-flick assay. KEY RESULTS The highly selective ECE2 inhibitor, S136492, significantly impaired μ receptor recycling and signalling by only those ligands that are ECE2 substrates and this was seen both in heterologous cells and in cells endogenously co-expressing μ receptors with ECE2. We also found that ECE2 inhibition attenuated antinociception mediated only by opioid peptides that are ECE2 substrates. CONCLUSIONS AND IMPLICATIONS These results suggest that ECE2, by selectively processing endogenous opioid peptides in the endocytic compartment, plays a role in modulating opioid receptor activity. LINKED ARTICLES This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2 PMID:24990314

Gas-permeable ethylene bags for the small scale cultivation of highly pathogenic avian influenza H5N1 and other viruses in embryonated chicken eggs.

PubMed

Hamilton, Sara B; Daniels, Deirdre E; Sosna, William A; Jeppesen, Eric R; Owells, Julie M; Halpern, Micah D; McCurdy, Kimberly S; Rayner, Jonathan O; Lednicky, John A

2010-01-28

Embryonated chicken eggs (ECE) are sometimes used for the primary isolation or passage of influenza viruses, other viruses, and certain bacteria. For small-scale experiments with pathogens that must be studied in biosafety level three (BSL3) facilities, inoculated ECE are sometimes manipulated and maintained in small egg incubators within a biosafety cabinet (BSC). To simplify the clean up and decontamination of an egg incubator in case of egg breakage, we explored whether ethylene breather bags could be used to encase ECE inoculated with pathogens. This concept was tested by determining embryo survival and examining virus yields in bagged ECE. Virus yields acceptable for many applications were attained when influenza-, alpha-, flavi-, canine distemper-, and mousepox viruses were propagated in ECE sealed within ethylene breather bags. For many small-scale applications, ethylene breather bags can be used to encase ECE inoculated with various viruses.

Preface: Impacts of extreme climate events and disturbances on carbon dynamics

USGS Publications Warehouse

Xiao, Jingfeng; Liu, Shuguang; Stoy, Paul C.

2016-01-01

The impacts of extreme climate events and disturbances (ECE&D) on the carbon cycle have received growing attention in recent years. This special issue showcases a collection of recent advances in understanding the impacts of ECE&D on carbon cycling. Notable advances include quantifying how harvesting activities impact forest structure, carbon pool dynamics, and recovery processes; observed drastic increases of the concentrations of dissolved organic carbon and dissolved methane in thermokarst lakes in western Siberia during a summer warming event; disentangling the roles of herbivores and fire on forest carbon dioxide flux; direct and indirect impacts of fire on the global carbon balance; and improved atmospheric inversion of regional carbon sources and sinks by incorporating disturbances. Combined, studies herein indicate several major research needs. First, disturbances and extreme events can interact with one another, and it is important to understand their overall impacts and also disentangle their effects on the carbon cycle. Second, current ecosystem models are not skillful enough to correctly simulate the underlying processes and impacts of ECE&D (e.g., tree mortality and carbon consequences). Third, benchmark data characterizing the timing, location, type, and magnitude of disturbances must be systematically created to improve our ability to quantify carbon dynamics over large areas. Finally, improving the representation of ECE&D in regional climate/earth system models and accounting for the resulting feedbacks to climate are essential for understanding the interactions between climate and ecosystem dynamics.

The District: A History of the Philadelphia District, U.S. Army Corps of Engineers, 1866-1971

DTIC Science & Technology

1974-01-01

events with the irresistible momentum of a juggernaut. With his partners, Erskine Hazard and George Hauto, White organized the Lehigh Navigation...within 3 years. White and Hazard explored and surveyed the river from Stoddartsville to Easton in the Spring of 1818, on foot and using levels 36...loaded. There were places where ships could ground in the Delaware channel without benefit of a full tide. One such hazard was at Schooner Ledge

Demographic consequences of migratory stopover: linking red knot survival to horseshoe crab spawning abundance

USGS Publications Warehouse

McGowan, Conor P.; Hines, James E.; Nichols, James D.; Lyons, James E.; Smith, David; Kalasz, Kevin S.; Niles, Lawrence J.; Dey, Amanda D.; Clark, Nigel A.; Atkinson, Philip W.; Minton, Clive D.T.; Kendall, William

2011-01-01

Understanding how events during one period of the annual cycle carry over to affect survival and other fitness components in other periods is essential to understanding migratory bird demography and conservation needs. Previous research has suggested that western Atlantic red knot (Calidris canutus rufa) populations are greatly affected by horseshoe crab (Limulus polyphemus) egg availability at Delaware Bay stopover sites during their spring northward migration. We present a mass-based multistate, capturerecapture/resighting model linking (1) red knot stopover mass gain to horseshoe crab spawning abundance and (2) subsequent apparent annual survival to mass state at the time of departure from the Delaware Bay stopover area. The model and analysis use capture-recapture/resighting data with over 16,000 individual captures and 13,000 resightings collected in Delaware Bay over a 12 year period from 1997–2008, and the results are used to evaluate the central management hypothesis that red knot populations can be influenced by horseshoe crab harvest regulations as part of a larger adaptive management effort. Model selection statistics showed support for a positive relationship between horseshoe crab spawning abundance during the stopover and the probability of red knots gaining mass (parameter coefficient from the top model b = 1.71, SE = 0.46). Our analyses also supported the link between red knot mass and apparent annual survival, although average estimates for the two mass classes differed only slightly. The addition of arctic snow depth as a covariate influencing apparent survival improved the fit of the data to the models (parameter coefficient from the top model b = 0.50, SE = 0.08). Our results indicate that managing horseshoe crab resources in the Delaware Bay has the potential to improve red knot population status.

Perceptions of Early Childhood Education Professionals on Teacher Leadership in Finland

ERIC Educational Resources Information Center

Heikka, Johanna; Halttunen, Leena; Waniganayake, Manjula

2018-01-01

This study investigated perceptions of early childhood education (ECE) professionals employed at three ECE centres on teacher leadership enactment in Finland. These professionals comprised childcare nurses, teachers and ECE centre directors. Theoretically, the study was anchored on an analysis of teacher leadership and distributed leadership…

Occurrence of equine coital exanthema (ECE) in stallions in Japan and effectiveness of treatment with valacyclovir for ECE

PubMed Central

TOISHI, Yuko; TSUNODA, Nobuo; KIRISAWA, Rikio

2017-01-01

Equine coital exanthema (ECE) has been reported in many countries, but equine herpesvirus 3 (EHV-3) has been isolated only once in Japan. In 2015, symptoms of ECE were found, and EHV-3 was isolated in two stallions. Valacyclovir, an anti-herpesvirus agent, was administered orally. The stallions rested from mating for more than two weeks, causing enormous financial losses because of their high fees. This is the first study in which valacyclovir was administered for ECE. Though valacyclovir treatment did not shorten the duration of healing, the affected area did not expand after administration of valacyclovir. Valacyclovir therefore seems to be effective for suppression of EHV-3 infection. Further investigation about the administration protocol might be required. PMID:28123140

Water and nitrogen availability co-control ecosystem CO2 exchange in a semiarid temperate steppe.

PubMed

Zhang, Xiaolin; Tan, Yulian; Li, Ang; Ren, Tingting; Chen, Shiping; Wang, Lixin; Huang, Jianhui

2015-10-23

Both water and nitrogen (N) availability have significant effects on ecosystem CO2 exchange (ECE), which includes net ecosystem productivity (NEP), ecosystem respiration (ER) and gross ecosystem photosynthesis (GEP). How water and N availability influence ECE in arid and semiarid grasslands is still uncertain. A manipulative experiment with additions of rainfall, snow and N was conducted to test their effects on ECE in a semiarid temperate steppe of northern China for three consecutive years with contrasting natural precipitation. ECE increased with annual precipitation but approached peak values at different precipitation amount. Water addition, especially summer water addition, had significantly positive effects on ECE in years when the natural precipitation was normal or below normal, but showed trivial effect on GEP when the natural precipitation was above normal as effects on ER and NEP offset one another. Nitrogen addition exerted non-significant or negative effects on ECE when precipitation was low but switched to a positive effect when precipitation was high, indicating N effect triggered by water availability. Our results indicate that both water and N availability control ECE and the effects of future precipitation changes and increasing N deposition will depend on how they can change collaboratively in this semiarid steppe ecosystem.

Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1–induced pruritus

PubMed Central

Kido-Nakahara, Makiko; Buddenkotte, Jörg; Kempkes, Cordula; Ikoma, Akihiko; Cevikbas, Ferda; Akiyama, Tasuku; Nunes, Frank; Seeliger, Stephan; Hasdemir, Burcu; Mess, Christian; Buhl, Timo; Sulk, Mathias; Müller, Frank-Ulrich; Metze, Dieter; Bunnett, Nigel W.; Bhargava, Aditi; Carstens, Earl; Furue, Masutaka; Steinhoff, Martin

2014-01-01

In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein–coupled receptor endothelin A receptor (ETAR). Here, we have identified neural endothelin–converting enzyme 1 (ECE-1) as a key regulator of ET-1–induced pruritus and neural signaling of itch. We show here that ETAR, ET-1, and ECE-1 are expressed and colocalize in murine dorsal root ganglia (DRG) neurons and human skin nerves. In murine DRG neurons, ET-1 induced internalization of ETAR within ECE-1–containing endosomes. ECE-1 inhibition slowed ETAR recycling yet prolonged ET-1–induced activation of ERK1/2, but not p38. In a murine itch model, ET-1–induced scratching behavior was substantially augmented by pharmacological ECE-1 inhibition and abrogated by treatment with an ERK1/2 inhibitor. Using iontophoresis, we demonstrated that ET-1 is a potent, partially histamine-independent pruritogen in humans. Immunohistochemical evaluation of skin from prurigo nodularis patients confirmed an upregulation of the ET-1/ETAR/ECE-1/ERK1/2 axis in patients with chronic itch. Together, our data identify the neural peptidase ECE-1 as a negative regulator of itch on sensory nerves by directly regulating ET-1–induced pruritus in humans and mice. Furthermore, these results implicate the ET-1/ECE-1/ERK1/2 pathway as a therapeutic target to treat pruritus in humans. PMID:24812665

Pharmacological hypothesis: Nitric oxide-induced inhibition of ADAM-17 activity as well as vesicle release can in turn prevent the production of soluble endothelin-converting enzyme.

PubMed

Kuruppu, Sanjaya; Rajapakse, Niwanthi W; Parkington, Helena C; Smith, Ian

2017-10-01

Endothelin-1 (ET-1) and nitric oxide (NO) are two highly potent vasoactive molecules with opposing effects on the vasculature. Endothelin-converting enzyme (ECE) and nitric oxide synthase (NOS) catalyse the production of ET-1 and NO, respectively. It is well established that these molecules play a crucial role in the initiation and progression of cardiovascular diseases and have therefore become targets of therapy. Many studies have examined the mechanism(s) by which NO regulates ET-1 production. Expression and localization of ECE-1 is a key factor that determines the rate of ET-1 production. ECE-1 can either be membrane bound or be released from the cell surface to produce a soluble form. NO has been shown to reduce the expression of both membrane-bound and soluble ECE-1. Several studies have examined the mechanism(s) behind NO-mediated inhibition of ECE expression on the cell membrane. However, the precise mechanism(s) behind NO-mediated inhibition of soluble ECE production are unknown. We hypothesize that both exogenous and endogenous NO, inhibits the production of soluble ECE-1 by preventing its release via extracellular vesicles (e.g., exosomes), and/or by inhibiting the activity of A Disintegrin and Metalloprotease-17 (ADAM17). If this hypothesis is proven correct in future studies, these pathways represent targets for the therapeutic manipulation of soluble ECE-1 production. © 2017 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

Creating an Agile ECE Learning Environment through Engineering Clinics

ERIC Educational Resources Information Center

Jansson, P. M.; Ramachandran, R. P.; Schmalzel, J. L.; Mandayam, S. A.

2010-01-01

To keep up with rapidly advancing technology, numerous innovations to the electrical and computer engineering (ECE) curriculum, learning methods and pedagogy have been envisioned, tested, and implemented. It is safe to say that no single approach will work for all of the diverse ECE technologies and every type of learner. However, a few key…

A Universal Early Childhood Education System

ERIC Educational Resources Information Center

Brown, Christopher P.

2006-01-01

In this article, the author demonstrates how the current emphasis on viewing early childhood education (ECE) as an investment keeps ECE at the margins of U.S. political debates as well as in other discussions around the world. Historically, the field of ECE in the United States has struggled, and continues to struggle, for political positioning.…

An initial reliability and validity study of the Interaction, Communication, and Literacy Skills Audit.

PubMed

El-Choueifati, Nisrine; Purcell, Alison; McCabe, Patricia; Heard, Robert; Munro, Natalie

2014-06-01

Early childhood educators (ECEs) have an important role in promoting positive outcomes for children's language and literacy development. This paper reports the development of a new tool, The Interaction Communication and Literacy (ICL) Skills Audit, and pilots its reliability and validity. Intra- and inter-rater reliability was examined by three speech-language pathologists (SLPs). Five skill areas relating to ECE language and literacy practice were rated. The face and content validity of the ICL Skills Audit was examined by expert SLPs (n = 8) and expert ECEs (n = 4) via questionnaire. The overall intra-rater reliability for the ICL Skills Audit was excellent with percentage close agreement (PCA) of 91-94. Inter-rater agreement was PCA 68-80. Expert SLPs and ECEs agreed that the content was comprehensive and practical. Based on this preliminary study, the ICL Skills Audit appears to be a promising tool that can be used by SLPs and ECEs in collaboration to measure the skills of ECEs in the areas of language and literacy support. Future psychometric and outcome research on the revised ICL Skills Audit is warranted.

Development and internal validation of a side-specific, multiparametric magnetic resonance imaging-based nomogram for the prediction of extracapsular extension of prostate cancer.

PubMed

Martini, Alberto; Gupta, Akriti; Lewis, Sara C; Cumarasamy, Shivaram; Haines, Kenneth G; Briganti, Alberto; Montorsi, Francesco; Tewari, Ashutosh K

2018-04-19

To develop a nomogram for predicting side-specific extracapsular extension (ECE) for planning nerve-sparing radical prostatectomy. We retrospectively analysed data from 561 patients who underwent robot-assisted radical prostatectomy between February 2014 and October 2015. To develop a side-specific predictive model, we considered the prostatic lobes separately. Four variables were included: prostate-specific antigen; highest ipsilateral biopsy Gleason grade; highest ipsilateral percentage core involvement; and ECE on multiparametric magnetic resonance imaging (mpMRI). A multivariable logistic regression analysis was fitted to predict side-specific ECE. A nomogram was built based on the coefficients of the logit function. Internal validation was performed using 'leave-one-out' cross-validation. Calibration was graphically investigated. The decision curve analysis was used to evaluate the net clinical benefit. The study population consisted of 829 side-specific cases, after excluding negative biopsy observations (n = 293). ECE was reported on mpMRI and final pathology in 115 (14%) and 142 (17.1%) cases, respectively. Among these, mpMRI was able to predict ECE correctly in 57 (40.1%) cases. All variables in the model except highest percentage core involvement were predictors of ECE (all P ≤ 0.006). All variables were considered for inclusion in the nomogram. After internal validation, the area under the curve was 82.11%. The model demonstrated excellent calibration and improved clinical risk prediction, especially when compared with relying on mpMRI prediction of ECE alone. When retrospectively applying the nomogram-derived probability, using a 20% threshold for performing nerve-sparing, nine out of 14 positive surgical margins (PSMs) at the site of ECE resulted above the threshold. We developed an easy-to-use model for the prediction of side-specific ECE, and hope it serves as a tool for planning nerve-sparing radical prostatectomy and in the reduction of PSM in future series. © 2018 The Authors BJU International © 2018 BJU International Published by John Wiley & Sons Ltd.

Total and inorganic arsenic in Mid-Atlantic marine fish and shellfish and implications for fish advisories.

PubMed

Greene, Richard; Crecelius, Eric

2006-10-01

Sampling was conducted in 2002 to determine the total concentration and chemical speciation of arsenic in several marine fish and shellfish species collected from the Delaware Inland Bays and the Delaware Estuary, both of which are important estuarine waterbodies in the US Mid-Atlantic region that support recreational and commercial fishing. Edible meats from summer flounder (Paralicthys dentatus), striped bass (Marone saxatilis), Atlantic croaker (Micropogonias undulates), and hard clam (Mercenaria mercenaria) were tested. Total arsenic was highest in summer flounder, followed by hard clam, then striped bass, and finally, Atlantic croaker. Total arsenic was higher in summer flounder collected during the spring, as these fish migrated into the Inland Bays from the continental shelf, compared with levels in summer flounder collected during the fall, after these fish had spent the summer in the Inland Bays. Similarly, striped bass collected in the early spring close to the ocean had higher total arsenic levels compared with levels detected in striped bass collected later during the year in waters with lower salinity. Speciation of arsenic revealed low concentrations (0.00048-0.02 microg/g wet wt) of toxic inorganic arsenic. Dimethylarsinic acid was more than an order of magnitude greater in hard clam meats than in the other species tested, a finding that was attributed to arsenic uptake by phytoplankton and subsequent dietary uptake by the clam. Risk assessment using the inorganic arsenic concentrations was used to conclude that a fish consumption advisory is not warranted.

E.C.E. Connection: A Newsletter for Early Childhood Education (E.C.E.), 1994-1998.

ERIC Educational Resources Information Center

E.C.E. Connection, 1998

1998-01-01

This document consists of the first 39 consecutive issues of the newsletter, "E.C.E. Connection," published monthly (except August) to offer information and support to early childhood practitioners. Articles from the 1994 issues include: "Some 'Affordable' Ideas To Brighten Your Classroom"; "A Notice Board: A Way To Keep…

Global Vision, Local Reality: Transforming Pre-Primary Teacher Training in Tanzania

ERIC Educational Resources Information Center

Wilinski, Bethany; Nguyen, Cuong Huy; Landgraf, Jessica M.

2016-01-01

Global attention to early childhood education (ECE) has led to an increased focus on ECE teacher training as a critical component of providing young children with access to high-quality ECE programs. In this paper, we ask how Tanzanian stakeholders at different levels of implementation experienced and responded to efforts to build capacity in…

Getting Early Childhood Educators Up and Running: Creating Strong Technology Curators, Facilitators, Guides, and Users. Policy Brief

ERIC Educational Resources Information Center

Daugherty, Lindsay; Dossani, Rafiq; Johnson, Erin-Elizabeth; Wright, Cameron

2014-01-01

Providers of early childhood education (ECE) are well positioned to help ensure that technology is used effectively in ECE settings. Indeed, the successful integration of technology into ECE depends on providers who have the ability to curate the most appropriate devices and content, "facilitate" effective patterns of use, guide families…

A Design of an Appropriate Early Childhood Education Funding System in China

ERIC Educational Resources Information Center

Xiaodong, Zeng

2008-01-01

This study analyzes the structural reform of local governments funding for early childhood education (ECE) as the general public still casts doubts about the fairness of ECE system in China. A particular case in point is the Shenzhen Municipal Government's reform on their ECE funding system. Because the reform efforts are more about restructuring…

Diversity in New Zealand Early Childhood Education: Challenges and Opportunities

ERIC Educational Resources Information Center

Shuker, Mary Jane; Cherrington, Sue

2016-01-01

The early childhood education (ECE) sector in New Zealand has long been recognised for the diversity of service types and range of organisations involved in delivering ECE. However, less attention has been paid to diversity within individual ECE services. This article draws on a national survey carried out as part of a larger project, "The…

Music Education from Birth to Five: An Examination of Early Childhood Educators' Music Teaching Practices

ERIC Educational Resources Information Center

Bolduc, Jonathan; Evrard, Melanie

2017-01-01

Children from birth to five are generally enthusiastic about music. However, because many early-childhood educators (ECEs) feel that they have insufficient knowledge to foster musical development, music education practices are not equivalent across ECEs. This study aimed to identify and determine the frequency of music activities used by ECEs. In…

Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in older subjects.

PubMed

Iemitsu, Motoyuki; Maeda, Seiji; Otsuki, Takeshi; Sugawara, Jun; Tanabe, Takumi; Jesmin, Subrina; Kuno, Shinya; Ajisaka, Ryuichi; Miyauchi, Takashi; Matsuda, Mitsuo

2006-05-01

Increase in arterial stiffness is associated with aging, which is improved by regular exercise. Endothelin (ET) system has crucial roles in regulating vascular tone and in the progression of atherosclerosis. We hypothesized that molecular variations (ie, gene polymorphisms) in ET-related gene might affect exercise-induced improvement in arterial stiffness with age in human subjects. The present study provides a cross-sectional investigation of 191 healthy middle-aged and older (65+/-1 years) human subjects to clarify the relationship between the regular exercise-induced improvement of arterial stiffness and the gene polymorphisms of ET converting enzyme (ECE)-1, ECE-2, ET-A receptor (ET-A), and ET-B receptor (ET-B). The study subjects were divided into active and inactive groups based on the median value (186 kcal/d) of energy expenditure. Brachial-ankle arterial pulse wave velocity (baPWV) was used to evaluate arterial stiffness. All individuals were genotyped for 4 different polymorphisms of the ET system: 2013(+289)A/G in intron 17 of ECE-1, 669(+17)T/C in intron 5 of ECE-2, 958A/G in exon 6 of ET-A, and 831A/G in exon 4 of ET-B. The baseline baPWV was significantly lower in the active group without any change in blood pressure. Polymorphisms in ECE-1 influenced basal blood pressure. Polymorphisms in ECE-1 and ECE-2 had no effect on baPWV between active and inactive groups. However, polymorphisms in both ET-A and ET-B affected baPWV in the 2 groups. The present results suggest that differences in ET-A and ET-B polymorphisms may influence the response of the vascular wall to exercise whereas ECE-1 polymorphisms may affect basal blood pressure.

Opioid Receptor Function Is Regulated by Post-endocytic Peptide Processing*

PubMed Central

Gupta, Achla; Gomes, Ivone; Wardman, Jonathan; Devi, Lakshmi A.

2014-01-01

Most neuroendocrine peptides are generated in the secretory compartment by proteolysis of the precursors at classical cleavage sites consisting of basic residues by well studied endopeptidases belonging to the subtilisin superfamily. In contrast, a subset of bioactive peptides is generated by processing at non-classical cleavage sites that do not contain basic residues. Neither the peptidases responsible for non-classical cleavages nor the compartment involved in such processing has been well established. Members of the endothelin-converting enzyme (ECE) family are considered good candidate enzymes because they exhibit functional properties that are consistent with such a role. In this study we have explored a role for ECE2 in endocytic processing of δ opioid peptides and its effect on modulating δ opioid receptor function by using selective inhibitors of ECE2 that we had identified previously by homology modeling and virtual screening of a library of small molecules. We found that agonist treatment led to intracellular co-localization of ECE2 with δ opioid receptors. Furthermore, selective inhibitors of ECE2 and reagents that increase the pH of the acidic compartment impaired receptor recycling by protecting the endocytosed peptide from degradation. This, in turn, led to a substantial decrease in surface receptor signaling. Finally, we showed that treatment of primary neurons with the ECE2 inhibitor during recycling led to increased intracellular co-localization of the receptors and ECE2, which in turn led to decreased receptor recycling and signaling by the surface receptors. Together, these results support a role for differential modulation of opioid receptor signaling by post-endocytic processing of peptide agonists by ECE2. PMID:24847082

Water Quality of the Upper Delaware Scenic and Recreational River and Tributary Streams, New York and Pennsylvania

USGS Publications Warehouse

Siemion, Jason; Murdoch, Peter S.

2010-01-01

Water-quality samples were collected from the Upper Delaware Scenic and Recreational River (UPDE) and its tributaries during the period October 1, 2005, to September 30, 2007, to document existing water quality, determine relations between land use and water quality, and identify areas of water-quality concern. A tiered water-quality monitoring framework was used, with the tiers consisting of intensively sampled sites, gradient sites representing the range of land uses present in the basin, and regional stream-survey sites. Median nitrate and total phosphorous concentrations were 1.15 and 0.01 mg/L (milligrams per liter) for three sites on the mainstem Delaware River, 1.27 and 0.009 mg/L for the East Branch Delaware River, 2.04 and 0.01 mg/L for the West Branch Delaware River, and 0.68 and 0.006 mg/L for eight tributaries that represent the range of land uses resent in the basin, respectively. The percentage of agricultural land varied by basin from 0 to 30 percent and the percentage of suburbanization varied from 0 to 17 percent. There was a positive correlation between the percentage of agricultural land use in a basin and observed concentrations of acid neutralizing capacity, calcium, potassium, nitrate, and total dissolved nitrogen, whereas no correlation between the percentage of suburbanization and water quality was detected. Results of stream surveys showed that nitrate concentrations in 55 to 65 percent of the UPDE Basin exceeded the nitrate reference condition and a suggested water-quality guideline for ecological impairment in New York State (0.98 mg/L) during the spring. Many of the affected parts of the basin were more than 90 percent forested and showed signs of episodic acidification, indicating that the long-term effects of acid deposition play a role in the high nitrate levels. Nitrate concentrations in 75 percent of samples collected from agricultural sites exceeded the suggested nitrate water-quality guideline for ecological impairment. Concentrations of nitrate and total phosphorous in samples collected from agricultural sites also were twice and 25 percent higher than those in samples from reference sites, respectively.

Giant Electrocaloric Effect in Ferroelectrics with Tailored Polaw-Nanostructures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Qiming

2015-06-24

Electrocaloric effect (ECE) is the temperature and/or entropy change in a dielectric material caused by an electric field induced polarization change. Although ECE has been studied since 1930s, the very small ECE observed in earlier studies in bulk materials before 2007 makes it not attractive for practical cooling applications. The objectives of this DOE program are to carry out a systematical scientific research on the entropy change and ECE in polar-dielectrics, especially ferroelectrics based on several fundamental hypotheses and to search for answers on a few scientific questions. Especially, this research program developed a series of polar-dielectric materials with controlledmore » nano- and meso-structures and carried out studies on how these structures affect the polar-ordering, correlations, energy landscapes, and consequently the entropy states at different phases and ECE. The key hypotheses of the program include: (i) Whether a large ECE can be obtained near the ferroelectric-paraelectric (FE-PE) transition in properly designed ferroelectrics which possess large polarization P and large ß (the coefficient in the thermodynamic Landau theory where the Gibbs free energy G = G = G 0+ ½ a P 2 +1/4 b P 4 + 1/6 c P 6 – EP, and a = ß (T-T c), where b,c,ß and Tc are constants)? (ii) What determines/determine ß? Whether a ferroelectric material with built-in disorders, which disrupt the polar-correlations and enabling a large number of local polar-states, such as a properly designed ferroelectric relaxor, can achieve a large ECE? (iii) How to design a ferroelectric material which has flat energy landscape so that the energy barriers for switching among different phases are vanishingly small? What are the necessary conditions to maximize the number of coexisting phases? (iv) How to design ferroelectric materials with a large tunable dielectric response? That is, at zero electric field, the material possesses very low polar-correlation and hence a very small dielectric constant, under the application of electric field, the material develops long range polar-correlation and hence a high dielectric response. Studying and developing these materials will deepen our understanding on the polarization responses in strongly coupled materials and the roles of molecular and nano, meso-, and micro-scale defects and structures on the polarization responses. On the application front, besides ECE, these dielectrics will also have great impact on micro-electronics and communications. (v) The multi-field effect, besides the electric, elastic and even magnetic effects, could be made use of to tune the energy landscape of polar-materials and hence enhance the ECE. Hence the question is what are the suitable material systems to develop and maximize the multi-field effects? (vi) Besides solid dielectric, liquid dielectrics with properly designed molecular structures and dipolar coupling can also exhibit a large ECE near the dipolar order-disorder transition. The study of order-disorder transition and their influence on entropy change and ECE will provide additional avenue to study dielectrics and understand relationship between the polar-ordering and dipolar entropy in dielectrics. (vii) Besides the regular ECE in which applying an electric field will induce dipolar ordering, there are dielectric material systems which can exhibit negative ECE in which the applied field will reduce the dipolar ordering and anomalous ECE in which applying an electric field pulse will generate cooling only. The question is how to control and balance the nano- and meso-scale polar coupling in dielectrics to achieve such effects? ECE in dielectrics provides an interesting and effective avenue to probe the polar-correlation in dielectrics. Thus the study of ECE in polar-dielectrics, besides the application values, will also deepen our understanding of strongly coupled materials systems, phase transitions, and materials systems with nano- and meso-scale disorders. Through the efforts of this DoE program, we have developed understandings for many questions and materials approaches for many hypotheses listed above. The major accomplishments include: (i) The first one to show that a giant ECE can be obtained in bulk materials of ferroelectric P(VDF-TrFE) copolymer, which has a large ß coefficient and high polarization, near FE-PE transition.[1,3,12] (ii) The first who developed the theoretical analyses on the upper bound of dipolar entropy change in polar-materials and the general approach to maximize the coexisting phases with vanishingly small switching fields among the coexisting phases[10,23] Experimental results confirm these theoretical predictions.[24] (iii) The first to show that the relaxor ferroelectrics, due to built-in defects structures at nano- and meso scale, exhibit a giant ECE over a broad temperature range.[1,3,7,14] (iv) The first to show that a large ECE can be obtained near order-disorder transition in dielectric fluids such as liquid crystals with large dielectric anisotropy. Also the study developed a general approach for developing dielectric fluids to achieve a large electric field induced entropy change.[26] (v) We are starting to explore the multi-field effect (multiferroic effect) in nanocomposites in which there exist large dielectric contrasts between the matrix and nanofilelrs and showed that a significantly enhanced ECE compared with polymer matrix.[36] (vi) By facially tuning the nano- and meso-scale dipolar coupling, we are the first to show that an anomalous ECE can be obtained in a relaxor/normal ferroelectric blend.[39] (vii) Introduced and demonstrated that the internal bias field approach can be effective in enhancing the EC response at low electric field. The result is significant since for practical applications, a low applied field is highly desired. (viii) A high sensitivity ECE characterization system has been developed. This program has made major contributions to the advancement of the EC materials and understandings of EC phenomena. To reflect the advancement in the EC materials development and scientific understandings on ECE through in this time period (from Sept. 1, 2007 to May 2015), this final report is written based on the reports complied each year through the program. Some early works on the ECE which were obtained using the indirect method are not included in this report.« less

Water resources data, Maryland and Delaware, water year 1997, volume 2. ground-water data

USGS Publications Warehouse

Smigaj, Michael J.; Saffer, Richard W.; Starsoneck, Roger J.; Tegeler, Judith L.

1998-01-01

The Water Resources Division of the U.S. Geological Survey, in cooperation with State agencies, obtains a large amount of data pertaining to the water resources of Maryland and Delaware each water year. These data, accumulated during many water years, constitute a valuable data base for developing an improved understanding of the water resources of the State. To make these data readily available to interested parties outside the U.S. Geological Survey, the data are published annually in this report series entitled 'Water Resources Data - Maryland and Delaware.' This series of annual reports for Maryland and Delaware began with the 1961 water year with a report that contained only data relating to the quantities of surface water. For the 1964 water year, a similar report was introduced that contained only data relating to water quality. Beginning with the l975 water year, the report format was changed to present, in one volume, data on quantities of surface water, quality of surface and ground water, and ground-water levels. In the 1989 water year, the report format was changed to two volumes. Both volumes contained data on quantities of surface water, quality of surface and ground water, and ground-water levels. Volume 1 contained data on the Atlantic Slope Basins (Delaware River thru Patuxent River) and Volume 2 contained data on the Monongahela and Potomac River basins. Beginning with the 1991 water year, Volume 1 contains all information on quantities of surface water and surface- water-quality data and Volume 2 contains ground-water levels and ground-water-quality data. This report is Volume 2 in our 1998 series and includes records of water levels and water quality of ground-water wells and springs. It contains records for water levels at 397 observation wells, discharge data for 6 springs, and water quality at 107 wells. Location of ground-water level wells are shown on figures 3 and 4. The location for the ground-water-quality sites are shown on figures 5. These data represent that part of the National Water Data System collected by the U.S. Geological Survey and cooperating State and Federal agencies in Maryland and Delaware. Prior to introduction of this series and for several water years concurrent with it, water resources data for Maryland and Delaware were published in U.S. Geological Survey Water-Supply Papers. Data on water levels for the 1935 through 1974 water years were published under the title 'Ground-Water Levels in the United States.' The above mentioned Water-Supply Papers may be consulted in the libraries of the principal cities of the United States and may be purchased from the Branch of Information Services, Federal Center, Bldg. 41, Box 25286, Denver, CO 80225-0286. Publications similar to this report are published annually by the Geological Survey for all States. These official Survey reports have an identification number consisting of the two-letter State abbreviation, the last two digits of the water year, and the volume number. For example, this volume is identified as 'U.S. Geological Survey Water-Data Report MD-DE-98-2.' For archiving and general distribution, the reports for l971- 74 water years also are identified as water data reports. These water-data reports are for sale in paper copy or in microfiche by the National Technical Information Service, U.S. Department of Commerce, Springfield, VA 22161. Additional information, including current prices, for ordering specific reports may be obtained from the District Chief at the address given on the back of the title page or by telephone (410)238-4200.

Professional Development of the Early Childhood Education Teaching Workforce in the United States: An Overview

ERIC Educational Resources Information Center

Gomez, Rebecca E.; Kagan, Sharon Lynn; Fox, Emily A.

2015-01-01

Resulting from a fragmented landscape of policies for and uneven investments in the early childhood education (ECE) field in the United States, the qualifications of the ECE teaching workforce are typically quite low. This article first reviews the history and status of the ECE teaching workforce in the United States, focusing on the evolution of…

When Business Gets Involved: A Case Study of Business Community Involvement In Illinois' Early Childhood Education Policy

ERIC Educational Resources Information Center

Kovach, Melissa

2009-01-01

As the first state to offer universal preschool to three-year-olds, Illinois' experience with early childhood education (ECE) policy reform efforts offers lessons about how such change takes shape. This report details Illinois' ECE activities from 1992 to the present, with a particular focus on the business role in ECE policy. Lessons learned…

Shared Services: A Powerful Strategy to Support Sustainability of ECE Businesses

ERIC Educational Resources Information Center

Stoney, Louise

2009-01-01

As Co-Founder of the Alliance for Early Childhood Finance, it is the author's job to think about how they pay for early care and education (ECE) services in the United States. Generating the operating revenue needed to establish and sustain a high-quality ECE program has never been easy--and in a recession economy it is becoming even more…

Effect of Male and Female Early Childhood Education Teacher's Educational Practices on Children's Social Adaptation

ERIC Educational Resources Information Center

Besnard, Thérèse; Letarte, Marie-Josée

2017-01-01

It is believed children stand to benefit from a greater male teacher presence in early childhood education (ECE) where, internationally, the vast majority of ECE teachers are female. This study (N = 180) examines the relationship between children's social adaptation and the educational practices of 53 ECE teachers, 23 (44%) of which were male.…

Impacts of an In-Service Education Program on Promoting Language Development in Young Children: A Pilot Study with Early Childhood Educators

ERIC Educational Resources Information Center

Scarinci, Nerina; Rose, Tanya; Pee, Jerrine; Webb, Kylie

2015-01-01

Early childhood educators (ECEs) play an important role in fostering language development in young children. In-service education, led by speech-language pathologists (SLPs), has a potential role in educating ECEs about language development. In this pilot study, 42 ECEs attended an in-service education program and completed pre- and…

"Old, Borrowed, and Renewed": A Review of Early Childhood Education Policy in Post-Reform Indonesia

ERIC Educational Resources Information Center

Octarra, Harla Sara; Hendriati, Agustina

2018-01-01

Early childhood education (ECE) is not new in Indonesia. However, in the past decade, it has received more attention, as shown by the growing number of ECE centres in both urban and rural areas. This growth is accompanied by policy development that corresponds to the global agenda of ECE. Policy development is inevitably linked with the support of…

The ECE Pre-Service Teachers' Perception on Factors Affecting the Integration of Educational Computer Games in Two Conditions: Selecting versus Redesigning

ERIC Educational Resources Information Center

Sancar Tokmak, Hatice; Ozgelen, Sinan

2013-01-01

This case study aimed to examine early childhood education (ECE) pre-service teachers' perception on the factors affecting integration of educational computer games to their instruction in two areas: selecting and redesigning. Twenty-six ECE pre-service teachers participated in the study. The data was collected through open-ended questionnaires,…

The build-up of energetic electrons triggering electron cyclotron emission bursts due to a magnetohydrodynamic mode at the edge of tokamaks

DOE PAGES

Li, Erzhong; Austin, Max E.; White, R. B.; ...

2017-08-21

Intense bursts of electron cyclotron emission (ECE) triggered by magnetohydrodynamic (MHD) instabilities such as edge localized modes (ELMs) have been observed on many tokamaks. On the DIII-D tokamak, it is found that an MHD mode is observed to trigger the ECE bursts in the low collisionality regime at the plasma edge. ORBIT-code simulations have shown that energetic electrons build up due to an interaction between barely trapped electrons with an MHD mode (f = 50 kHz for current case). The energetic tail of the electron distribution function develops a bump within several microseconds for this collisionless case. This behavior dependsmore » on the competition between the perturbing MHD mode and slowing down and pitch angle scattering due to collisions. As a result, for typical DIII-D parameters, the calculated ECE radiation transport predicted by ORBIT is in excellent agreement with ECE measurements, clarifying the electron dynamics of the ECE bursts for the first time.« less

Suspended-Sediment Impacts on Light-limited Productivity in the Delaware Estuary

NASA Astrophysics Data System (ADS)

McSweeney, J.; Chant, R. J.; Wilkin, J.; Sommerfield, C. K.

2016-12-01

The Delaware Estuary has a history of high anthropogenic nutrient loadings, but has been classified as a high-nutrient, low-growth system due persistent light limitations caused by turbidity. While the biogeochemical implications of light limitation in turbid estuaries has been well-studied, there has been minimal effort focused on the connectivity between hydrodynamics, sediment dynamics, and light-limitation. Our understanding of sediment dynamics in the Delaware Estuary has advanced significantly in the last decade, and this study provides insight about how the spatiotemporal variability of the estuarine turbidity maximum controls the light available for primary productivity. This analysis uses data from eight along-estuary cruises from March, June, September, and December 2010 and 2011 to look at the seasonality of suspended sediment and chlorophyll distributions. By estimating the absorption due to sediment under a range of environmental conditions, we describe how the movement of the turbidity maximum affects light availability. We also use an idealized 2-dimensional Regional Ocean Modeling System (ROMS) numerical model to evaluate how river discharge and spring-neap variability modulate the location of phytoplankton blooms. We conclude that high river flows and neap tides can drive stratification that is strong enough to prevent sediment from being resuspended into the surface layer, thus providing light conditions favorable for primary productivity. This study sheds light on the importance of sediment in the limiting primary productivity, and the role of stratification in promoting production, highlighting the potential limitations of biogeochemical models that do not account for sediment absorption.

Exploring the Relationship between Early Childhood and Elementary Grade-Level Overlap and Early Childhood Teacher Output

ERIC Educational Resources Information Center

Fowler, R. Clarke

2017-01-01

This study explores the relationship between grade-level overlap between elementary education (ELED) and early childhood education (ECED) licenses and ECED teacher output. Analysis of Title 2 data indicates that ECED/ELED overlap is extensive, as evidenced by the number of states with grade-level overlaps of 5 (n = 2), 4 (n = 24), 3 (n = 10), and…

A Noble Bet in Early Care and Education: Lessons from One Community’s Experience

DTIC Science & Technology

2002-01-01

Finally, the RAND study team explored existing empirical literature on ECE. Although ECI led to the establishment of new , high-quality ECE ser...objectives and articulates the breadth of the initiative’s ambition to create a comprehensive new system for delivering ECE to low-income chil- dren in...70 Incentives to Neighborhood Agencies .............. 71 Who Would Provide ECI Services? . . . . . . . . . . . . . . . . . . 73 New Providers and

Status of the design of the ITER ECE diagnostic

DOE PAGES

Taylor, G.; Austin, M. E.; Beno, J. H.; ...

2015-03-12

In this study, the baseline design for the ITER electron cyclotron emission (ECE) diagnostic has entered the detailed preliminary design phase. Two plasma views are planned, a radial view and an oblique view that is sensitive to distortions in the electron momentum distribution near the average thermal momentum. Both views provide high spatial resolution electron temperature profiles when the momentum distribution remains Maxwellian. The ECE diagnostic system consists of the front-end optics, including two 1000 K calibration sources, in equatorial port plug EP9, the 70-1000 GHz transmission system from the front-end to the diagnostics hall, and the ECE instrumentation inmore » the diagnostics hall. The baseline ECE instrumentation will include two Michelson interferometers that can simultaneously measure ordinary and extraordinary mode ECE from 70 to 1000 GHz, and two heterodyne radiometer systems, covering 122-230 GHz and 244-355 GHz. Significant design challenges include 1) developing highly-reliable 1000 K calibration sources and the associated shutters/mirrors, 2) providing compliant couplings between the front-end optics and the polarization splitter box that accommodate displacements of the vacuum vessel during plasma operations and bake out, 3) protecting components from damage due to stray ECH radiation and other intense millimeter wave emission and 4) providing the low-loss broadband transmission system.« less

Repeatability and validity of a field kit for estimation of cholinesterase in whole blood.

PubMed Central

London, L; Thompson, M L; Sacks, S; Fuller, B; Bachmann, O M; Myers, J E

1995-01-01

OBJECTIVES--To evaluate a spectrophotometric field kit (Test-Mate-OP) for repeatability and validity in comparison with reference laboratory methods and to model its anticipated sensitivity and specificity based on these findings. METHODS--76 farm workers between the age of 20 and 55, of whom 30 were pesticide applicators exposed to a range of organophosphates in the preceding 10 days, had blood taken for plasma cholinesterase (PCE) and erythrocyte cholinesterase (ECE) measurement by field kit or laboratory methods. Paired blinded duplicate samples were taken from subgroups in the sample to assess repeatability of laboratory and field kit methods. Field kits were also used to test venous blood in one subgroup. The variance obtained for the field kit tests was then applied to two hypothetical scenarios that used published action guidelines to model the kit's sensitivity and specificity. RESULTS--Repeatability for PCE was much poorer and for ECE slightly poorer than that of laboratory measures. A substantial upward bias for field kit ECE relative to laboratory measurements was found. Sensitivity of the kit to a 40% drop in PCE was 67%, whereas that for ECE was 89%. Specificity of the kit with no change in mean of the population was 100% for ECE and 91% for PCE. CONCLUSION--Field kit ECE estimation seems to be sufficiently repeatable for surveillance activities, whereas PCE does not. Repeatability of both tests seems to be too low for use in epidemiological dose-response investigations. Further research is indicated to characterise the upward bias in ECE estimation on the kit. PMID:7697143

Does Gender Make a Difference? Results from the German "Tandem Study" on the Pedagogical Activity of Female and Male ECE Workers

ERIC Educational Resources Information Center

Brandes, Holger; Andrä, Markus; Röseler, Wenke; Schneider-Andrich, Petra

2015-01-01

Based on an everyday quasi-experimental situation with multiple materials, the behavior of male and female early childhood education (ECE) workers is recorded and compared. The research is based on a sample of 41 female and 41 male ECE workers, who in each case work together in tandem in a kindergarten class, as well as a control group of 12…

Temperature gradient scale length measurement: A high accuracy application of electron cyclotron emission without calibration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Houshmandyar, S., E-mail: houshmandyar@austin.utexas.edu; Phillips, P. E.; Rowan, W. L.

2016-11-15

Calibration is a crucial procedure in electron temperature (T{sub e}) inference from a typical electron cyclotron emission (ECE) diagnostic on tokamaks. Although the calibration provides an important multiplying factor for an individual ECE channel, the parameter ΔT{sub e}/T{sub e} is independent of any calibration. Since an ECE channel measures the cyclotron emission for a particular flux surface, a non-perturbing change in toroidal magnetic field changes the view of that channel. Hence the calibration-free parameter is a measure of T{sub e} gradient. B{sub T}-jog technique is presented here which employs the parameter and the raw ECE signals for direct measurement ofmore » electron temperature gradient scale length.« less

Hydrodynamic Restoration to Vulnerable Marsh Ecosystems to Improve Response to Sea Level Rise

NASA Astrophysics Data System (ADS)

Orescanin, M. M.; Hamilton, R. P., Jr.

2016-12-01

Rising sea levels pose imminent threats to low-lying marsh ecosystems owing to delicate balances between water levels, salinity, and sediment transport. Further complications arise from human modifications to these low-lying coastal areas that modify topography, thus altering tidal exchanges. The Milford Neck Conservation Area, near Milford, DE, is a salt marsh system on Delaware Bay that has undergone morphological modifications owing to both human activity and natural processes resulting in damage to the surrounding marsh habitats. A century-old abandoned canal acted as a physical barrier to any tidal exchange for upland marsh for decades, allowing land at low elevations to be dry and used for agricultural activities. However, a breach to the system in the 1980s created a link to Delaware Bay that flooded salt hay fields, creating a large area of open water. Owing to tidal restrictions in the system, it has been difficult to transport sufficient sediment and water into the system to promote natural marsh growth. At the same time, the eroding barrier beach increases vulnerability to sea level rise and storms of increasing severity and frequency, and places upland forest at risk of episodic salt intrusion. To increase the effectiveness of this area as a barrier to sea level rise, it is necessary to increase marsh resiliency. Hydrodynamic measurements collected during fall 2015 and spring/summer 2016 show tidal choking in the system that limits exchange of salt water from Delaware Bay and prevents drainage from storm runoff. Numerical model results using the hydrodynamic model, CMS-flow, confirm tidal choking in this system and suggest localized areas are responsible for the most significant reduction in tidal exchange between the marsh and Delaware Bay. Analysis of hypsometry of the area combined with potential for improving tidal flushing suggest the possibility of restoring close to 400 acres of open water and damaged marsh.

Implementation of a framework for multi-species, multi-objective adaptive management in Delaware Bay

USGS Publications Warehouse

McGowan, Conor P.; Smith, David R.; Nichols, James D.; Lyons, James E.; Sweka, John A.; Kalasz, Kevin; Niles, Lawrence J.; Wong, Richard; Brust, Jeffrey; Davis, Michelle C.; Spear, Braddock

2015-01-01

Decision analytic approaches have been widely recommended as well suited to solving disputed and ecologically complex natural resource management problems with multiple objectives and high uncertainty. However, the difference between theory and practice is substantial, as there are very few actual resource management programs that represent formal applications of decision analysis. We applied the process of structured decision making to Atlantic horseshoe crab harvest decisions in the Delaware Bay region to develop a multispecies adaptive management (AM) plan, which is currently being implemented. Horseshoe crab harvest has been a controversial management issue since the late 1990s. A largely unregulated horseshoe crab harvest caused a decline in crab spawning abundance. That decline coincided with a major decline in migratory shorebird populations that consume horseshoe crab eggs on the sandy beaches of Delaware Bay during spring migration. Our approach incorporated multiple stakeholders, including fishery and shorebird conservation advocates, to account for diverse management objectives and varied opinions on ecosystem function. Through consensus building, we devised an objective statement and quantitative objective function to evaluate alternative crab harvest policies. We developed a set of competing ecological models accounting for the leading hypotheses on the interaction between shorebirds and horseshoe crabs. The models were initially weighted based on stakeholder confidence in these hypotheses, but weights will be adjusted based on monitoring and Bayesian model weight updating. These models were used together to predict the effects of management actions on the crab and shorebird populations. Finally, we used a dynamic optimization routine to identify the state dependent optimal harvest policy for horseshoe crabs, given the possible actions, the stated objectives and our competing hypotheses about system function. The AM plan was reviewed, accepted and implemented by the Atlantic States Marine Fisheries Commission in 2012 and 2013. While disagreements among stakeholders persist, structured decision making enabled unprecedented progress towards a transparent and consensus driven management plan for crabs and shorebirds in Delaware Bay.

GPER mediates the age-dependent upregulation of the myocardial endothelin system

PubMed Central

Meyer, Matthias R.; Fredette, Natalie C.; Sharma, Geetanjali; Barton, Matthias; Prossnitz, Eric R.

2016-01-01

Aims Cardiac aging is associated with progressive structural changes and functional impairment, such as left ventricular hypertrophy, fibrosis and diastolic dysfunction. Aging also increases myocardial activity of endothelin-1 (ET-1), a multifunctional peptide with growth-promoting and pro-fibrotic activity. Because the G protein-coupled estrogen receptor (GPER) regulates vascular responsiveness to ET-1, we investigated whether GPER also plays a role in the regulation of the cardiac endothelin system with aging. Main methods Young (4 month-old) and aged (24 month-old) wild-type and Gper-deficient (Gper-/-) mice were studied. Gene expression levels of prepro-ET-1, endothelin converting enzymes ECE-1 and ECE-2, and endothelin ETA and ETB receptors were determined by qPCR in left ventricular myocardium. Key findings Aging markedly increased steady-state mRNA expression levels of ECE-1, ECE-2, ETA and ETB receptors (each p<0.001 vs. young mice). Deletion of Gper inhibited the age-dependent increase in ECE-2 and ETB receptor mRNA levels (57% and 40% reduction, respectively, each p<0.01 vs. wild-type mice), whereas gene expression of prepro-ET-1, ECE-1, or the ETA receptor was unaffected in Gper-/- mice. Significance We identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 and the ETB receptor, which is compatible with an activating role of GPER for the cardiac endothelin system with aging. Targeting GPER signaling by selective antagonists may therefore be considered a new therapeutic approach to reduce age-dependent increased ET-1 activity and the associated development of left ventricular hypertrophy, fibrosis and heart failure. PMID:26880534

Meals for Good: An innovative community project to provide healthy meals to children in early care and education programs through food bank catering.

PubMed

Carpenter, Leah R; Smith, Teresa M; Stern, Katherine; Boyd, Lisa Weissenburger-Moser; Rasmussen, Cristy Geno; Schaffer, Kelly; Shuell, Julie; Broussard, Karen; Yaroch, Amy L

2017-12-01

Innovative approaches to childhood obesity prevention are warranted in early care and education (ECE) settings, since intervening early among youth is recommended to promote and maintain healthy behaviors. The objective of the Meals for Good pilot was to explore feasibility of implementing a food bank-based catering model to ECE programs to provide more nutritious meals, compared to meals brought from home (a parent-prepared model). In 2014-2015, a 12-month project was implemented by a food bank in central Florida in four privately-owned ECE programs. An explanatory sequential design of a mixed-methods evaluation approach was utilized, including a pre-post menu analysis comparing parent-prepared meals to the catered meals, and stakeholder interviews to determine benefits and barriers. The menu analysis of lunches showed daily reductions in calories, fat, and saturated fat, but an increase in sodium in catered meals when compared to parent-prepared meals. Interviews with ECE directors, teachers, parents, and food bank project staff, identified several benefits of the catered meals, including healthfulness of meals, convenience to parents, and the ECE program's ability to market this meal service. Barriers of the catered meals included the increased cost to parents, transportation and delivery logistics, and change from a 5 to a 2-week menu cycle during summer food service. This pilot demonstrated potential feasibility of a food bank-ECE program partnership, by capitalizing on the food bank's existing facilities and culinary programming, and interest in implementing strategies focused on younger children. The food bank has since leveraged lessons learned and expanded to additional ECE programs.

Archaeal Extrachromosomal Genetic Elements

PubMed Central

Wang, Haina; Peng, Nan; Shah, Shiraz A.

2015-01-01

SUMMARY Research on archaeal extrachromosomal genetic elements (ECEs) has progressed rapidly in the past decade. To date, over 60 archaeal viruses and 60 plasmids have been isolated. These archaeal viruses exhibit an exceptional diversity in morphology, with a wide array of shapes, such as spindles, rods, filaments, spheres, head-tails, bottles, and droplets, and some of these new viruses have been classified into one order, 10 families, and 16 genera. Investigation of model archaeal viruses has yielded important insights into mechanisms underlining various steps in the viral life cycle, including infection, DNA replication and transcription, and virion egression. Many of these mechanisms are unprecedented for any known bacterial or eukaryal viruses. Studies of plasmids isolated from different archaeal hosts have also revealed a striking diversity in gene content and innovation in replication strategies. Highly divergent replication proteins are identified in both viral and plasmid genomes. Genomic studies of archaeal ECEs have revealed a modular sequence structure in which modules of DNA sequence are exchangeable within, as well as among, plasmid families and probably also between viruses and plasmids. In particular, it has been suggested that ECE-host interactions have shaped the coevolution of ECEs and their archaeal hosts. Furthermore, archaeal hosts have developed defense systems, including the innate restriction-modification (R-M) system and the adaptive CRISPR (clustered regularly interspaced short palindromic repeats) system, to restrict invasive plasmids and viruses. Together, these interactions permit a delicate balance between ECEs and their hosts, which is vitally important for maintaining an innovative gene reservoir carried by ECEs. In conclusion, while research on archaeal ECEs has just started to unravel the molecular biology of these genetic entities and their interactions with archaeal hosts, it is expected to accelerate in the next decade. PMID:25694123

GPER is required for the age-dependent upregulation of the myocardial endothelin system.

PubMed

Meyer, Matthias R; Fredette, Natalie C; Sharma, Geetanjali; Barton, Matthias; Prossnitz, Eric R

2016-08-15

Cardiac aging is associated with progressive structural changes and functional impairment, such as left ventricular hypertrophy, fibrosis and diastolic dysfunction. Aging also increases myocardial activity of endothelin-1 (ET-1), a multifunctional peptide with growth-promoting and pro-fibrotic activity. Because the G protein-coupled estrogen receptor (GPER) regulates vascular responsiveness to ET-1, we investigated whether GPER also plays a role in the regulation of the myocardial endothelin system with aging. Young (4month-old) and aged (24month-old) wild-type and Gper-deficient (Gper(-/-)) mice were studied. Gene expression levels of prepro-ET-1, endothelin converting enzymes ECE-1 and ECE-2, and endothelin ETA and ETB receptors were determined by qPCR in left ventricular myocardium. Aging markedly increased steady-state mRNA expression levels of ECE-1, ECE-2, ETA and ETB receptors (each p<0.001 vs. young mice). Deletion of Gper inhibited the age-dependent increase in ECE-2 and ETB receptor mRNA levels (57% and 40% reduction, respectively, each p<0.01 vs. wild-type mice), whereas gene expression of prepro-ET-1, ECE-1, and the ETA receptor was unaffected in Gper(-/-) mice. We identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 and the ETB receptor, which is compatible with an activating role of GPER for the local endothelin system with aging. Targeting GPER signaling by selective antagonists may therefore be considered a new therapeutic approach to reduce age-dependent increased ET-1 activity and the associated development of left ventricular hypertrophy, fibrosis and heart failure. Copyright © 2016 Elsevier Inc. All rights reserved.

No phenotypic plasticity in nest-site selection in response to extreme flooding events.

PubMed

Bailey, Liam D; Ens, Bruno J; Both, Christiaan; Heg, Dik; Oosterbeek, Kees; van de Pol, Martijn

2017-06-19

Phenotypic plasticity is a crucial mechanism for responding to changes in climatic means, yet we know little about its role in responding to extreme climatic events (ECEs). ECEs may lack the reliable cues necessary for phenotypic plasticity to evolve; however, this has not been empirically tested. We investigated whether behavioural plasticity in nest-site selection allows a long-lived shorebird ( Haematopus ostralegus ) to respond to flooding. We collected longitudinal nest elevation data on individuals over two decades, during which time flooding events have become increasingly frequent. We found no evidence that individuals learn from flooding experiences, showing nest elevation change consistent with random nest-site selection. There was also no evidence of phenotypic plasticity in response to potential environmental cues (lunar nodal cycle and water height). A small number of individuals, those nesting near an artificial sea wall, did show an increase in nest elevation over time; however, there is no conclusive evidence this occurred in response to ECEs. Our study population showed no behavioural plasticity in response to changing ECE patterns. More research is needed to determine whether this pattern is consistent across species and types of ECEs. If so, ECEs may pose a major challenge to the resilience of wild populations.This article is part of the themed issue 'Behavioural, ecological and evolutionary responses to extreme climatic events'. © 2017 The Author(s).

Elevated CO2 maintains grassland net carbon uptake under a future heat and drought extreme

PubMed Central

Roy, Jacques; Picon-Cochard, Catherine; Augusti, Angela; Benot, Marie-Lise; Thiery, Lionel; Darsonville, Olivier; Landais, Damien; Piel, Clément; Defossez, Marc; Devidal, Sébastien; Escape, Christophe; Ravel, Olivier; Fromin, Nathalie; Volaire, Florence; Milcu, Alexandru; Bahn, Michael; Soussana, Jean-François

2016-01-01

Extreme climatic events (ECEs) such as droughts and heat waves are predicted to increase in intensity and frequency and impact the terrestrial carbon balance. However, we lack direct experimental evidence of how the net carbon uptake of ecosystems is affected by ECEs under future elevated atmospheric CO2 concentrations (eCO2). Taking advantage of an advanced controlled environment facility for ecosystem research (Ecotron), we simulated eCO2 and extreme cooccurring heat and drought events as projected for the 2050s and analyzed their effects on the ecosystem-level carbon and water fluxes in a C3 grassland. Our results indicate that eCO2 not only slows down the decline of ecosystem carbon uptake during the ECE but also enhances its recovery after the ECE, as mediated by increases of root growth and plant nitrogen uptake induced by the ECE. These findings indicate that, in the predicted near future climate, eCO2 could mitigate the effects of extreme droughts and heat waves on ecosystem net carbon uptake. PMID:27185934

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simonetto, A.; Sozzi, C.; Garavaglia, S.

A Martin Puplett interferometer for electron cyclotron emission (ECE) measurements from JET tokamak plasmas was extended to multichannel operation for simultaneous radial and oblique ECE measurements. This paper describes the new optics and the instrument's performance.

Design and first plasma measurements of the ITER-ECE prototype radiometer.

PubMed

Austin, M E; Brookman, M W; Rowan, W L; Danani, S; Bryerton, E W; Dougherty, P

2016-11-01

On ITER, second harmonic optically thick electron cyclotron emission (ECE) in the range of 220-340 GHz will supply the electron temperature (T e ). To investigate the requirements and capabilities prescribed for the ITER system, a prototype radiometer covering this frequency range has been developed by Virginia Diodes, Inc. The first plasma measurements with this instrument have been carried out on the DIII-D tokamak, with lab bench tests and measurements of third through fifth harmonic ECE from high T e plasmas. At DIII-D the instrument shares the transmission line of the Michelson interferometer and can simultaneously acquire data. Comparison of the ECE radiation temperature from the absolutely calibrated Michelson and the prototype receiver shows that the ITER radiometer provides accurate measurements of the millimeter radiation across the instrument band.

Exploitation of Unintentional Ethernet Cable Emissions Using Constellation Based-Distinct Native Attribute (CB-DNA) Fingerprints to Enhance Network Security

DTIC Science & Technology

2015-09-17

Exploitation of Unintentional Information Leakage from Inte- grated Circuits”. Ph.D. dissertation, ECE, AFIT, Wright- Patt AFB, OH, 2011. 16. Cobb, W. E...Ph.D. dissertation, ECE, AFIT, Wright- Patt AFB, OH, 2014. 48. Ramsey, B. W., Temple, M. A., and Mullins, B. E. PHY Foundation for Multi-Factor...dissertation, ECE, AFIT, Wright- Patt AFB, OH, 2012. 132 51. Reising, D. R., Temple, M. A., and Oxley, M. E. Gabor-Based RF-DNA Fingerprinting for

The Delaware Bay Estuary as a Classroom: A Research Experience for Future Elementary Grade-Level Teachers

NASA Astrophysics Data System (ADS)

Madsen, J.; Fifield, S.; Allen, D.; Shipman, H.; Ford, D.; Dagher, Z.; Brickhouse, N.

2004-05-01

With supplemental funding from the National Science Foundation (NSF), students from the University of Delaware's Science Semester course took part in a two-day research cruise in the Delaware Bay Estuary. The Science Semester, an NSF-funded project, is an integrated 15-credit sequence that encompasses the entire course work for the spring semester for approximately 60 sophomore-level elementary education majors. The semester includes the earth, life, and physical science content courses and the education science methods course integrated into one curriculum. In this curriculum, problem-based learning and other inquiry-based approaches are applied to foster integrated understandings of science and pedagogy that future elementary teachers need to effectively use inquiry-based approaches in their classrooms. The research cruise was conducted as part of one of the four major investigations during the course. The investigation focused on Delaware's state marine animal, Limulus polyphemus. It is one of the four remaining species of horseshoe crabs; the largest spawning population of Limulus is found in Delaware Bay. Within the problem- and inquiry-based learning approaches of the Science Semester course, the students became aware that very little data exists on the benthic habitat of Limulus polyphemus. In order to learn more about this habitat, a cohort of seven students from the course was recruited as part of the scientific party to take part in the research cruise to collect data on the floor of Delaware Bay. The data included: multibeam bathymetry/backscatter data, grab samples of bay bottom sediments, and CTD profiles. Prior to the cruise, all students in the course took part in laboratory exercises to learn about topographic maps and navigation charts using the Delaware Bay area as the region of study. While "at-sea", the cruise participants sent the ship's latitude and longitude positions as a function of time. The positions were used by the on-land students to investigate motion and data representation (e.g., distance vs. time, velocity vs. time plots). After the at-sea experience, and using the data collected, all of the students plotted the sampling locations on their navigation charts and examined and quantitatively described the bottom sediments collected with the grab samples. The CTD data were used to investigate solutions, salinity, and conductivity. The ability to participate in, and use the data collected from, the two-day cruise provided an excellent opportunity for these future elementary teachers to experience real-time scientific research. The students onboard the ship were able to observe, and more importantly, engage in the collection of data from an oceanographic research vessel. All of the students in the course through hands-on laboratory exercises were able to see the link between data collection and analysis and its subsequent interpretation within the scope of a real scientific problem, namely the study of the benthic habitat of an important marine animal.

Cadence Feedback With ECE PEDO to Monitor Physical Activity Intensity: A Pilot Study.

PubMed

Ardic, Fusun; Göcer, Esra

2016-03-01

The purpose of this study was to examine the monitoring capabilities of the equipment for clever exercise pedometer (ECE PEDO) that provides audible feedback when the person exceeds the upper and lower limits of the target step numbers per minute and to compare step counts with Yamax SW-200 (YX200) as the criterion pedometer.A total of 30 adult volunteers (15 males and 15 females) were classified as normal weight (n = 10), overweight (n = 10), and obese (n = 10). After the submaximal exercise test on a treadmill, the moderate intensity for walking was determined by using YX200 pedometer and then the number of steps taken in a minute was measured. Lower and upper limits of steps per minute (cadence) were recorded in ECE PEDO providing audible feedback when the person's walking speed gets out of the limits. Volunteers walked for 30 minutes in the individual step count range by attaching the ECE PEDO and YX200 pedometer on both sides of the waist belt in the same session. Step counts of the volunteers were recorded. Wilcoxon, Spearman correlation, and Bland-Altman analyses were performed to show the relationship and agreement between the results of 2 devices.Subjects took an average of 3511 ± 426 and 3493 ± 399 steps during 30 minutes with ECE PEDO and criterion pedometer, respectively. About 3500 steps taken by ECE PEDO reflected that this pedometer has capability of identifying steps per minute to meet moderate intensity of physical activity. There was a strong correlation between step counts of both devices (P < 0.001, r = 0.96). Correlations across all three BMI categories and both sex remained consistently high ranging from 0.92 to 0.95. There was a high level of agreement between the ECE PEDO and YX200 pedometer in the Bland-Altman analysis.Although both devices showed a strong similarity in counting steps, the ECE PEDO provides monitoring of intensity such that a person can walk in a specified time with a desired speed.

Cadence Feedback With ECE PEDO to Monitor Physical Activity Intensity

PubMed Central

Ardic, Fusun; Göcer, Esra

2016-01-01

Abstract The purpose of this study was to examine the monitoring capabilities of the equipment for clever exercise pedometer (ECE PEDO) that provides audible feedback when the person exceeds the upper and lower limits of the target step numbers per minute and to compare step counts with Yamax SW-200 (YX200) as the criterion pedometer. A total of 30 adult volunteers (15 males and 15 females) were classified as normal weight (n = 10), overweight (n = 10), and obese (n = 10). After the submaximal exercise test on a treadmill, the moderate intensity for walking was determined by using YX200 pedometer and then the number of steps taken in a minute was measured. Lower and upper limits of steps per minute (cadence) were recorded in ECE PEDO providing audible feedback when the person's walking speed gets out of the limits. Volunteers walked for 30 minutes in the individual step count range by attaching the ECE PEDO and YX200 pedometer on both sides of the waist belt in the same session. Step counts of the volunteers were recorded. Wilcoxon, Spearman correlation, and Bland–Altman analyses were performed to show the relationship and agreement between the results of 2 devices. Subjects took an average of 3511 ± 426 and 3493 ± 399 steps during 30 minutes with ECE PEDO and criterion pedometer, respectively. About 3500 steps taken by ECE PEDO reflected that this pedometer has capability of identifying steps per minute to meet moderate intensity of physical activity. There was a strong correlation between step counts of both devices (P < 0.001, r = 0.96). Correlations across all three BMI categories and both sex remained consistently high ranging from 0.92 to 0.95. There was a high level of agreement between the ECE PEDO and YX200 pedometer in the Bland–Altman analysis. Although both devices showed a strong similarity in counting steps, the ECE PEDO provides monitoring of intensity such that a person can walk in a specified time with a desired speed. PMID:26962822

Attitude of medical students towards Early Clinical Exposure in learning endocrine physiology

PubMed Central

Sathishkumar, Solomon; Thomas, Nihal; Tharion, Elizabeth; Neelakantan, Nithya; Vyas, Rashmi

2007-01-01

Background Different teaching-learning methods have been used in teaching endocrine physiology for the medical students, so as to increase their interest and enhance their learning. This paper describes the pros and cons of the various approaches used to reinforce didactic instruction in endocrine physiology and goes on to describe the value of adding an Early Clinical Exposure program (ECE) to didactic instruction in endocrine physiology, as well as student reactions to it as an alternative approach. Discussion Various methods have been used to reinforce didactic instruction in endocrine physiology such as case-stimulated learning, problem-based learning, patient-centred learning and multiple-format sessions. We devised a teaching-learning intervention in endocrine physiology, which comprised of traditional didactic lectures, supplemented with an ECE program consisting of case based lectures and a hospital visit to see patients. A focus group discussion was conducted with the medical students and, based on the themes that emerged from it, a questionnaire was developed and administered to further enquire into the attitude of all the students towards ECE in learning endocrine physiology. The students in their feedback commented that ECE increased their interest for the subject and motivated them to read more. They also felt that ECE enhanced their understanding of endocrine physiology, enabled them to remember the subject better, contributed to their knowledge of the subject and also helped them to integrate their knowledge. Many students said that ECE increased their sensitivity toward patient problems and needs. They expressed a desire and a need for ECE to be continued in teaching endocrine physiology for future groups of students and also be extended for teaching other systems as well. The majority of the students (96.4%) in their feedback gave an overall rating of the program as good to excellent on a 5 point Likert scale. Summary The ECE program was introduced as an alternative approach to reinforce didactic instruction in endocrine physiology for the first year medical students. The study demonstrated that students clearly enjoyed the experience and perceived that it was valuable. This method could potentially be used for other basic science topics as well. PMID:17784967

Multiparametric magnetic resonance imaging for the assessment of extracapsular invasion and other staging parameters in patients with prostate cancer candidates for radical prostatectomy.

PubMed

Lista, F; Gimbernat, H; Cáceres, F; Rodríguez-Barbero, J M; Castillo, E; Angulo, J C

2014-06-01

the proper evaluation of the extracapsular extension (ECE), the invasion of seminal vesicles and regional lymph nodes are necessary to plan the treatment of localized prostate cancer. A model that assesses the risk of ECE in the specimen considering the clinical, histological and imaging findings is defined. prospective study in 85 patients with prostate cancer treated with radical prostatectomy. Prostate biopsy was performed 4 weeks before multiparametric study (mpMRI). mpMRI included T2-weighted endorectal magnetic resonance imaging (T2W-MRI), diffusion-weighted magnetic resonance imaging (DW-MRI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The apparent diffusion coefficient (ADC) was also measured. A study of consistency (k) was assessed comparing receiver operating characteristic (ROC) curve and area under the curve (AUC), which were obtained in each case (Z). Finally, a regression model was performed to predict ECE. the mean age was 63.7 ± 6.9 years and the mean value of PSA 12.6 ± 13.8. In 31.7% of cases, digital rectal examination was suspicious for malignancy. Prostatectomy specimen showed pT2a in 12 cases (14%), pT2b in 3 (3%), pT2c in 37 (43%), pT3a in 19(22%) and pT3b 14 cases (17%). ECE was evidenced in 33 (39%) of the specimens, seminal vesicle invasion in 14 (16.5%) and pelvic node involvement in 5 patients (6%). The consistency in the evaluation of ECE (image and pathological studies) was .35 for MRI (sensitivity .33, specificity .96) and .62 for mpMRI (sensitivity .58, specificity .98). Mean value of ADC was .76 ± .2 in patients with ECE. This value was not associated with Gleason score (P = .2) or with PSA value (P = .6). AUC value as predictor of ECE was of 65% for MRI, 78% for mpMRI and 50% ADC (Z = .008). Univariate analysis demonstrated that ECE probability increases with each Gleason score point, whilst this probability increases 1.06 times with each PSA point, and decreases .3 times with each point of ADC. Multivariate analysis confirmed that ADC value is a slight protective factor against ECE (OR = .01; CI 95% .002-.14). The consistency in the evaluation of seminal vesicles was .43 for MRI and .67 for mpMRI. AUC was 69% and 82% respectively (Z = .02). The consistency in the evaluation of positive lymph nodes was .4 for MRI and .7 for mpMRI. AUC was 68% and 88% respectively (Z = .36). multiparametric study allows to carry out a more proper preoperative evaluation of ECE than convectional MRI. The most reliable predictors of ECE are DW-MRI combined with DCE-MRI, ADC coefficient and Gleason score. The superiority of mpMRI is also demonstrated for detection of seminal vesicles invasion, but not for the evaluation of lymph nodes invasion. Copyright © 2013 AEU. Published by Elsevier Espana. All rights reserved.

Design and first plasma measurements of the ITER-ECE prototype radiometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Austin, M. E.; Brookman, M. W.; Rowan, W. L.

2016-11-15

On ITER, second harmonic optically thick electron cyclotron emission (ECE) in the range of 220-340 GHz will supply the electron temperature (T{sub e}). To investigate the requirements and capabilities prescribed for the ITER system, a prototype radiometer covering this frequency range has been developed by Virginia Diodes, Inc. The first plasma measurements with this instrument have been carried out on the DIII-D tokamak, with lab bench tests and measurements of third through fifth harmonic ECE from high T{sub e} plasmas. At DIII-D the instrument shares the transmission line of the Michelson interferometer and can simultaneously acquire data. Comparison of themore » ECE radiation temperature from the absolutely calibrated Michelson and the prototype receiver shows that the ITER radiometer provides accurate measurements of the millimeter radiation across the instrument band.« less

High-frequency intrinsic dynamics of the electrocaloric effect from direct atomistic simulations

NASA Astrophysics Data System (ADS)

Lisenkov, S.; Ponomareva, I.

2018-05-01

We propose a computational methodology capable of harvesting isothermal heat and entropy change in molecular dynamics simulations. The methodology is applied to study high-frequency dynamics of the electrocaloric effect (ECE) in ferroelectric PbTiO3. ECE is associated with a reversible change in temperature under adiabatic application of electric field or with a reversible change in entropy under isothermal application of the electric field. Accurate assessment of electrocaloric performance requires the knowledge of three quantities: isothermal heat, isothermal entropy change, and adiabatic temperature change. Our methodology allows computations of all these quantities directly, that is, without restoring to the reversible thermodynamical models. Consequently, it captures both reversible and irreversible effects, which is critical for ECE simulations. The approach is well suited to address the dynamics of the ECE, which so far remains underexplored. We report the following basic features of the intrinsic dynamics of ECE: (i) the ECE is independent of the electric field frequency, rate of application, or field profile; (ii) the effect persists up to the frequencies associated with the onset of dielectric losses and deteriorates from there due to the creation of irreversible entropy; and (iii) in the vicinity of the phase transition and in the paraelectric phase the onset of irreversible dynamics occurs at lower frequency as compared to the ferroelectric phase. The latter is attributed to lower intrinsic soft-mode frequencies and and larger losses in the paraelectric phase.

Quasi-adiabatic calorimeter for direct electrocaloric measurements

NASA Astrophysics Data System (ADS)

Sanlialp, Mehmet; Shvartsman, Vladimir V.; Faye, Romain; Karabasov, Maksim O.; Molin, Christian; Gebhardt, Sylvia; Defay, Emmanuel; Lupascu, Doru C.

2018-03-01

The electrocaloric effect (ECE) in ferroelectric materials is a promising candidate for small, effective, low cost, and environmentally friendly solid state cooling applications. Instead of the commonly used indirect estimates based on Maxwell's relations, direct measurements of the ECE are required to obtain reliable values. In this work, we report on a custom-made quasi-adiabatic calorimeter for direct ECE measurements. The ECE is measured for two promising lead-free materials: Ba(Zr0.12Ti0.88)O3 and Ba(Zr0.2Ti0.8)O3 bulk ceramics. Adiabatic temperature changes of ΔTEC = 0.5 K at 355 K and ΔTEC = 0.3 K at 314 K were achieved under the application of an electric field of 2 kV/mm for the Ba(Zr0.12Ti0.88)O3 and Ba(Zr0.2Ti0.8)O3 samples, respectively. The quasi-adiabatic ECE measurements reliably match other direct EC measurements using a differential scanning calorimeter or an infrared camera. The data are compared to indirect EC estimations based on Maxwell's relations and show that the indirect measurements typically underestimate the effect to a certain degree.

Location priority for non-formal early childhood education school based on promethee method and map visualization

NASA Astrophysics Data System (ADS)

Ayu Nurul Handayani, Hemas; Waspada, Indra

2018-05-01

Non-formal Early Childhood Education (non-formal ECE) is an education that is held for children under 4 years old. The implementation in District of Banyumas, Non-formal ECE is monitored by The District Government of Banyumas and helped by Sanggar Kegiatan Belajar (SKB) Purwokerto as one of the organizer of Non-formal Education. The government itself has a program for distributing ECE to all villages in Indonesia. However, The location to construct the ECE school in several years ahead is not arranged yet. Therefore, for supporting that program, a decision support system is made to give some recommendation villages for constructing The ECE building. The data are projected based on Brown’s Double Exponential Smoothing Method and utilizing Preference Ranking Organization Method for Enrichment Evaluation (Promethee) to generate priority order. As the recommendations system, it generates map visualization which is colored according to the priority level of sub-district and village area. The system was tested with black box testing, Promethee testing, and usability testing. The results showed that the system functionality and Promethee algorithm were working properly, and the user was satisfied.

Commissioning of inline ECE system within waveguide based ECRH transmission systems on ASDEX upgrade

NASA Astrophysics Data System (ADS)

Bongers, W. A.; Kasparek, W.; Doelman, N.; van den Braber, R.; van den Brand, H.; Meo, F.; de Baar, M. R.; Amerongen, F. J.; Donné, A. J. H.; Elzendoorn, B. S. Q.; Erckmann, V.; Goede, A. P. H.; Giannone, L.; Grünwald, G.; Hollman, F.; Kaas, G.; Krijger, B.; Michel, G.; Lubyako, L.; Monaco, F.; Noke, F.; Petelin, M.; Plaum, B.; Purps, F.; ten Pierik, J. G. W.; Schüller, C.; Slob, J. W.; Stober, J. K.; Schütz, H.; Wagner, D.; Westerhof, E.; Ronden, D. M. S.

2012-09-01

A CW capable inline electron cyclotron emission (ECE) separation system for feedback control, featuring oversized corrugated waveguides, is commissioned on ASDEX upgrade (AUG). The system is based on a combination of a polarization independent, non-resonant, Mach-Zehnder diplexer equipped with dielectric plate beam splitters [2, 3] employed as corrugated oversized waveguide filter, and a resonant Fast Directional Switch, FADIS [4, 5, 6, 7] as ECE/ECCD separation system. This paper presents an overview of the system, the low power characterisation tests and first high power commissioning on AUG.

33 CFR 165.511 - Security Zone; Atlantic Ocean, Chesapeake & Delaware Canal, Delaware Bay, Delaware River and its...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Security Zone; Atlantic Ocean, Chesapeake & Delaware Canal, Delaware Bay, Delaware River and its tributaries. 165.511 Section 165.511... Limited Access Areas Fifth Coast Guard District § 165.511 Security Zone; Atlantic Ocean, Chesapeake...

33 CFR 165.511 - Security Zone; Atlantic Ocean, Chesapeake & Delaware Canal, Delaware Bay, Delaware River and its...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; Atlantic Ocean, Chesapeake & Delaware Canal, Delaware Bay, Delaware River and its tributaries. 165.511 Section 165.511... Limited Access Areas Fifth Coast Guard District § 165.511 Security Zone; Atlantic Ocean, Chesapeake...

33 CFR 165.511 - Security Zone; Atlantic Ocean, Chesapeake & Delaware Canal, Delaware Bay, Delaware River and its...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; Atlantic Ocean, Chesapeake & Delaware Canal, Delaware Bay, Delaware River and its tributaries. 165.511 Section 165.511... Limited Access Areas Fifth Coast Guard District § 165.511 Security Zone; Atlantic Ocean, Chesapeake...

33 CFR 165.511 - Security Zone; Atlantic Ocean, Chesapeake & Delaware Canal, Delaware Bay, Delaware River and its...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Security Zone; Atlantic Ocean, Chesapeake & Delaware Canal, Delaware Bay, Delaware River and its tributaries. 165.511 Section 165.511... Limited Access Areas Fifth Coast Guard District § 165.511 Security Zone; Atlantic Ocean, Chesapeake...

33 CFR 165.511 - Security Zone; Atlantic Ocean, Chesapeake & Delaware Canal, Delaware Bay, Delaware River and its...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone; Atlantic Ocean, Chesapeake & Delaware Canal, Delaware Bay, Delaware River and its tributaries. 165.511 Section 165.511... Limited Access Areas Fifth Coast Guard District § 165.511 Security Zone; Atlantic Ocean, Chesapeake...

The influence of data characteristics on detecting wetland/stream surface-water connections in the Delmarva Peninsula, Maryland and Delaware

USGS Publications Warehouse

Vanderhoof, Melanie; Distler, Hayley; Lang, Megan W.; Alexander, Laurie C.

2018-01-01

The dependence of downstream waters on upstream ecosystems necessitates an improved understanding of watershed-scale hydrological interactions including connections between wetlands and streams. An evaluation of such connections is challenging when, (1) accurate and complete datasets of wetland and stream locations are often not available and (2) natural variability in surface-water extent influences the frequency and duration of wetland/stream connectivity. The Upper Choptank River watershed on the Delmarva Peninsula in eastern Maryland and Delaware is dominated by a high density of small, forested wetlands. In this analysis, wetland/stream surface water connections were quantified using multiple wetland and stream datasets, including headwater streams and depressions mapped from a lidar-derived digital elevation model. Surface-water extent was mapped across the watershed for spring 2015 using Landsat-8, Radarsat-2 and Worldview-3 imagery. The frequency of wetland/stream connections increased as a more complete and accurate stream dataset was used and surface-water extent was included, in particular when the spatial resolution of the imagery was finer (i.e., <10 m). Depending on the datasets used, 12–60% of wetlands by count (21–93% of wetlands by area) experienced surface-water interactions with streams during spring 2015. This translated into a range of 50–94% of the watershed contributing direct surface water runoff to streamflow. This finding suggests that our interpretation of the frequency and duration of wetland/stream connections will be influenced not only by the spatial and temporal characteristics of wetlands, streams and potential flowpaths, but also by the completeness, accuracy and resolution of input datasets.

An exploration of Early Childhood Education students’ knowledge and preparation to facilitate physical activity for preschoolers: a cross-sectional study

PubMed Central

2014-01-01

Background Early childhood educators play an important role in influencing preschoolers’ physical activity levels. The current study sought to explore Early Childhood Education (ECE) students’ physical activity-related knowledge and educational experience during their formal training in Ontario. Methods A total of 1,113 ECE students from 20 Ontario Colleges completed the study survey (online or on paper), which examined students’ physical activity course content; awareness of physical activity guidelines; understanding of health-related benefits of physical activity; self-efficacy to facilitate physical activity for preschoolers; self-reported physical activity levels; as well as physical activity-related resource needs. Descriptive statistics and independent samples t-tests were used to analyze the quantitative findings. Results Survey results identified that 72.1% of ECE students had not completed any physical activity/physical education specific courses, while only 28.7% were familiar with, and 2.0% accurately reported, the Canadian Physical Activity Guidelines for the Early Years. Only 10.5% of ECE students reported personal physical activity behaviors consistent with national recommendations for adults (150 minutes/week). ECE students’ mean overall task self-efficacy to facilitate physical activity was 7.37 (SD = 1.64). Self-efficacy was significantly higher (p < .05) when students had taken one or more courses devoted to physical activity/physical education, as well as when students engaged in sufficient physical activity to meet the national guidelines for adults (p < .05). Conclusions The results indicate that the current ECE college curriculum represents an excellent opportunity to provide future childcare providers with enriched physical activity-related training and support, such as physical activity guidelines, workshops, and new ideas for activities. Emphasizing the health benefits of physical activity for adults might be important in light of ECE students’ low self-reported physical activity levels. PMID:25034415

UNAVCO's Education and Community Engagement Program: Evaluating Five years of Geoscience Education and Community Outreach

NASA Astrophysics Data System (ADS)

Charlevoix, D. J.; Dutilly, E.

2017-12-01

In 2013, UNAVCO, a facility co-sponsored by the NSF and NASA, received a five-year award from the NSF: Geodesy Advancing Geosciences and EarthScope (GAGE). Under GAGE, UNAVCO's Education and Community Engagement (ECE) program conducts outreach and education activities, in essence broader impacts for the scientific community and public. One major challenge of this evaluation was the breadth and depth of the dozens of projects conducted by the ECE program under the GAGE award. To efficiently solve this problem of a large-scale program evaluation, we adopted a deliberative democratic (DD) approach that afforded UNAVCO ECE staff a prominent voice in the process. The evaluator directed staff members to chose the projects they wished to highlight as case studies of their finest broader impacts work. The DD approach prizes inclusion, dialogue, and deliberation. The evaluator invited ECE staff to articulate qualities of great programs and develop a case study of their most valuable broader impacts work. To anchor the staff's opinion in more objectivity than opinion, the evaluator asked each staff member to articulate exemplary qualities of their chosen project, discuss how these qualities fit their case study, and helped staff to develop data collection systems that lead to an evidence-based argument in support of their project's unique value. The results of this evaluation show that the individual ECE work areas specialized in certain kinds of projects. However, when viewed at the aggregate level, ECE projects spanned almost the entire gamut of NSF broader impacts categories. Longitudinal analyses show that since the beginning of the GAGE award, many projects grew in impact from year 1 to year 5. While roughly half of the ECE projects were prior work projects, by year five at least 33% of projects were newly developed under GAGE. All selected case studies exemplified how education and outreach work can be productively tied to UNAVCO's core mission of promoting geodesy.

Role of LA Shape in Predicting Embolic Cerebrovascular Events in Mitral Stenosis

PubMed Central

Nunes, Maria Carmo P.; Handschumacher, Mark D.; Levine, Robert A.; Barbosa, Marcia M.; Carvalho, Vinicius T.; Esteves, William A.; Zeng, Xin; Guerrero, J. Luis; Zheng, Hui; Tan, Timothy C.; Hung, Judy

2015-01-01

OBJECTIVES This study was designed to assess the role of left atrial (LA) shape in predicting embolic cerebrovascular events (ECE) in patients with mitral stenosis (MS). BACKGROUND Patients with rheumatic MS are at increased risk for ECE. LA remodeling in response to MS involves not only chamber dilation but also changes in the shape. We hypothesized that a more spherical LA shape may be associated with increased embolic events due to predisposition to thrombus formation or to atrial arrhythmias compared with an elliptical-shaped LA of comparable volume. METHODS A total of 212 patients with MS and 20 control subjects were enrolled. LA volume, LA emptying fraction, and cross-sectional area were measured by 3-dimensional (3D) transthoracic echocardiography. LA shape was expressed as the ratio of measured LA end-systolic volume to hypothetical sphere volume ([4/3π r3] where r was obtained from 3D cross-sectional area). The lower the LA shape index, the more spherical the shape. RESULTS A total of 41 patients presented with ECE at the time of enrollment or during follow-up. On multivariate analysis, LA 3D emptying fraction (adjusted odds ratio [OR]: 0.96; 95% confidence interval [CI]: 0.92 to 0.99; p = 0.028) and LA shape index (OR: 0.73; 95% CI: 0.61 to 0.87; p < 0.001) emerged as important factors associated with ECE, after adjustment for age and anticoagulation therapy. In patients in sinus rhythm, LA shape index remained associated with ECE (OR: 0.79; 95% CI: 0.67 to 0.94; p = 0.007), independent of age and LA function. An in vitro phantom atrial model demonstrated more stagnant flow profiles in spherical compared with ellipsoidal chamber. CONCLUSIONS In rheumatic MS patients, differential LA remodeling affects ECE risk. A more spherical LA shape was independently associated with an increased risk for ECE, adding incremental value in predicting events beyond that provided by age and LA function. PMID:24831206

Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones

PubMed Central

Pelayo, Juan-Carlos; Poole, Daniel P; Steinhoff, Martin; Cottrell, Graeme S; Bunnett, Nigel W

2011-01-01

Abstract Neuropeptide signalling at the plasma membrane is terminated by neuropeptide degradation by cell-surface peptidases, and by β-arrestin-dependent receptor desensitization and endocytosis. However, receptors continue to signal from endosomes by β-arrestin-dependent processes, and endosomal sorting mediates recycling and resensitization of plasma membrane signalling. The mechanisms that control signalling and trafficking of receptors in endosomes are poorly defined. We report a major role for endothelin-converting enzyme-1 (ECE-1) in controlling substance P (SP) and the neurokinin 1 receptor (NK1R) in endosomes of myenteric neurones. ECE-1 mRNA and protein were expressed by myenteric neurones of rat and mouse intestine. SP (10 nm, 10 min) induced interaction of NK1R and β-arrestin at the plasma membrane, and the SP–NK1R–β-arrestin signalosome complex trafficked by a dynamin-mediated mechanism to ECE-1-containing early endosomes, where ECE-1 can degrade SP. After 120 min, NK1R recycled from endosomes to the plasma membrane. ECE-1 inhibitors (SM-19712, PD-069185) and the vacuolar H+ATPase inhibitor bafilomycin A1, which prevent endosomal SP degradation, suppressed NK1R recycling by >50%. Preincubation of neurones with SP (10 nm, 5 min) desensitized Ca2+ transients to a second SP challenge after 10 min, and SP signals resensitized after 60 min. SM-19712 inhibited NK1R resensitization by >90%. ECE-1 inhibitors also caused sustained SP-induced activation of extracellular signal-regulated kinases, consistent with stabilization of the SP–NK1R–β-arrestin signalosome. By degrading SP and destabilizing endosomal signalosomes, ECE-1 has a dual role in controlling endocytic signalling and trafficking of the NK1R: promoting resensitization of G protein-mediated plasma membrane signalling, and terminating β-arrestin-mediated endosomal signalling. PMID:21878523

Tuning the electrocaloric enhancement near the morphotropic phase boundary in lead-free ceramics

NASA Astrophysics Data System (ADS)

Le Goupil, Florian; McKinnon, Ruth; Koval, Vladimir; Viola, Giuseppe; Dunn, Steve; Berenov, Andrey; Yan, Haixue; Alford, Neil Mcn.

2016-06-01

The need for more energy-efficient and environmentally-friendly alternatives in the refrigeration industry to meet global emission targets has driven efforts towards materials with a potential for solid state cooling. Adiabatic depolarisation cooling, based on the electrocaloric effect (ECE), is a significant contender for efficient new solid state refrigeration techniques. Some of the highest ECE performances reported are found in compounds close to the morphotropic phase boundary (MPB). This relationship between performance and the MPB makes the ability to tune the position of the MPB an important challenge in electrocaloric research. Here, we report direct ECE measurements performed on MPB tuned NBT-06BT bulk ceramics with a combination of A-site substitutions. We successfully shift the MPB of these lead-free ceramics closer to room temperature, as required for solid state refrigeration, without loss of the criticality of the system and the associated ECE enhancement.

Tuning the electrocaloric enhancement near the morphotropic phase boundary in lead-free ceramics

PubMed Central

Le Goupil, Florian; McKinnon, Ruth; Koval, Vladimir; Viola, Giuseppe; Dunn, Steve; Berenov, Andrey; Yan, Haixue; Alford, Neil McN.

2016-01-01

The need for more energy-efficient and environmentally-friendly alternatives in the refrigeration industry to meet global emission targets has driven efforts towards materials with a potential for solid state cooling. Adiabatic depolarisation cooling, based on the electrocaloric effect (ECE), is a significant contender for efficient new solid state refrigeration techniques. Some of the highest ECE performances reported are found in compounds close to the morphotropic phase boundary (MPB). This relationship between performance and the MPB makes the ability to tune the position of the MPB an important challenge in electrocaloric research. Here, we report direct ECE measurements performed on MPB tuned NBT-06BT bulk ceramics with a combination of A-site substitutions. We successfully shift the MPB of these lead-free ceramics closer to room temperature, as required for solid state refrigeration, without loss of the criticality of the system and the associated ECE enhancement. PMID:27312287

Design and first plasma measurements of the ITER-ECE prototype radiometer

DOE PAGES

Austin, M. E.; Brookman, M. W.; Rowan, W. L.; ...

2016-08-09

On ITER, second harmonic optically thick electron cyclotron emission (ECE) in the range of 220-340 GHz will supply the electron temperature (T e). In order to investigate the requirements and capabilities prescribed for the ITER system, a prototype radiometer covering this frequency range has been developed by Virginia Diodes, Inc. The first plasma measurements with this instrument have been carried out on the DIII-D tokamak, with lab bench tests and measurements of third through fifth harmonic ECE from high T e plasmas. At DIII-D the instrument shares the transmission line of the Michelson interferometer and can simultaneously acquire data. Inmore » our comparison of the ECE radiation temperature from the absolutely calibrated Michelson and the prototype receiver we show that the ITER radiometer provides accurate measurements of the millimeter radiation across the instrument band.« less

Tuning the electrocaloric enhancement near the morphotropic phase boundary in lead-free ceramics.

PubMed

Le Goupil, Florian; McKinnon, Ruth; Koval, Vladimir; Viola, Giuseppe; Dunn, Steve; Berenov, Andrey; Yan, Haixue; Alford, Neil McN

2016-06-17

The need for more energy-efficient and environmentally-friendly alternatives in the refrigeration industry to meet global emission targets has driven efforts towards materials with a potential for solid state cooling. Adiabatic depolarisation cooling, based on the electrocaloric effect (ECE), is a significant contender for efficient new solid state refrigeration techniques. Some of the highest ECE performances reported are found in compounds close to the morphotropic phase boundary (MPB). This relationship between performance and the MPB makes the ability to tune the position of the MPB an important challenge in electrocaloric research. Here, we report direct ECE measurements performed on MPB tuned NBT-06BT bulk ceramics with a combination of A-site substitutions. We successfully shift the MPB of these lead-free ceramics closer to room temperature, as required for solid state refrigeration, without loss of the criticality of the system and the associated ECE enhancement.

External validation of a nomogram for prediction of side-specific extracapsular extension at robotic radical prostatectomy.

PubMed

Zorn, Kevin C; Gallina, Andrea; Hutterer, Georg C; Walz, Jochen; Shalhav, Arieh L; Zagaja, Gregory P; Valiquette, Luc; Gofrit, Ofer N; Orvieto, Marcelo A; Taxy, Jerome B; Karakiewicz, Pierre I

2007-11-01

Several staging tools have been developed for open radical prostatectomy (ORP) patients. However, the validity of these tools has never been formally tested in patients treated with robot-assisted laparoscopic radical prostatectomy (RALP). We tested the accuracy of an ORP-derived nomogram in predicting the rate of extracapsular extension (ECE) in a large RALP cohort. Serum prostate specific antigen (PSA) and side-specific clinical stage and biopsy Gleason sum information were used in a previously validated nomogram predicting side-specific ECE. The nomogram-derived predictions were compared with the observed rate of ECE, and the accuracy of the predictions was quantified. Each prostate lobe was analyzed independently. As complete data were available for 576 patients, the analyses targeted 1152 prostate lobes. Median age and serum PSA concentration at radical prostatectomy were 60 years and 5.4 ng/mL, respectively. The majority of side-specific clinical stages were T(1c) (993; 86.2%). Most side-specific biopsy Gleason sums were 6 (572; 49.7%). The median side-specific percentages of positive cores and of cancer were, respectively, 20.0% and 5.0%. At final pathologic review, 107 patients (18.6%) had ECE, and side-specific ECE was present in 117 patients (20.3%). The nomogram was 89% accurate in the RALP cohort v 84% in the previously reported ORP validation. The ORP side-specific ECE nomogram is highly accurate in the RALP population, suggesting that predictive and possibly prognostic tools developed in ORP patients may be equally accurate in their RALP counterparts.

Early Clinical Exposure as a Learning Tool to Teach Neuroanatomy for First Year MBBS Students.

PubMed

Kar, Maitreyee; Kar, Chinmaya; Roy, Hironmoy; Goyal, Parmod

2017-12-01

Early clinical exposure (ECE) is one of the important tools to teach basic science to the MBBS students. It is one form of vertical integration between basic science and clinical subjects. This study is an effort at exploring the use of ECE as a motivational tool toward better learning in neuroanatomy for first year MBBS students. This study aims to make the students interested and motivated to study neuroanatomy by using ECE as learning tool in neuroanatomy and to make the students enable to retain the knowledge of neuroanatomy more efficiently and correlate the knowledge of neuroanatomy with neuromedicine. This study was conducted in collaboration with the Departments of Anatomy, General Medicine and Medical Education Unit in the year 2016. This was cross-sectional study. One hundred and fifty students of 1 st Professional MBBS were subdivided into two groups. After preliminary classes on brain, brainstem, and spinal cord for both groups, conventional lecture classes were taken for Group A only on upper motor neuron (UMN) and lower motor neuron (LMN) paralysis, and only Group B visited General Medicine ward where HOD, General Medicine showed and examined patients of UMN paralysis and LMN paralysis, elicited different symptoms, and discussed different investigation. It was followed by assessment of all by problem-based multiple choice questions (MCQ) and short answer questions. Then, Group B attended lecture class on different cranial nerve palsy whereas Group A visited medicine ward. It was followed by assessment of both groups by problem-based MCQ and short answer questions. The performance was compared. Then, the feedback of the students on ECE was collected by means of reflection writing followed by administration of questionnaire. Then, the perception of teachers regarding ECE was recorded by focused group discussion. Student's t -test was used to compare the performance of both batches. Reflection writing and focus group discussion were analyzed qualitatively. There was a significant difference in Group A ( P = 0.019) but no significant difference in Group B ( P = 0.679). All the teachers opined that ECE was an efficient method but more time and interdepartmental collaboration were necessary. Group A improved performance due to ECE but Group B maintained the motivational effect of it. Therefore, ECE can be used as an effective learning tool.

The Impact of Magnetic Resonance Imaging on Prediction of Extraprostatic Extension and Prostatectomy Outcome in Patients with Low-, Intermediate- and High-Risk Prostate Cancer: Try to Find a Standard.

PubMed

Radtke, Jan Philipp; Hadaschik, Boris A; Wolf, Maya B; Freitag, Martin T; Schwab, Constantin; Alt, Celine; Roth, Wilfried; Duensing, Stefan; Pahernik, Sascha A; Roethke, Matthias C; Schlemmer, Heinz-Peter; Hohenfellner, Markus; Teber, Dogu

2015-12-01

To investigate the value of multiparametric magnetic resonance imaging (mpMRI) and to predict extracapsular extension (ECE), seminal vesicle (SV) infiltration, and a negative surgical margin (SM) status at radical prostatectomy (RP) for different prostate cancer (PC) risk groups. In the study, 805 men underwent 3 tesla mpMRI without endorectal coil before MRI/transrectal ultrasonography-fusion guided prostate biopsy. MRIs were analyzed using the prostate imaging reporting and data system. The cohort was classified into risk groups according to National Comprehensive Cancer Network (NCCN) criteria. Of 132 men who subsequently underwent RP, pathologic stage and SM status at RP were used as reference. Retrospectively, we investigated a European Society of Urogenital Radiology (ESUR) score for ECE and SV-infiltration. Statistical analyses included regression analyses, receiver operating characteristics (ROC), and Youden Index to assess an ESUR-score cutoff. Area under the curve in ROC curve analyses was 0.82 for ESUR-ECE score to detect pT(3a)-disease and 0.77 for ESUR-SV score for pT(3b). Using a cutoff of 4 for ECE and of 2 for SV, the positive predictive value of the ECE-score for harboring pT(3) was 50.0%, 90.0%, and 88.8% for the low-, intermediate- and high-risk cohort. Retrospectively, the use of the ESUR-ECE score preoperatively would have changed the initial surgical plan, according to NCCN criteria, in 31.1% of patients. In the high-risk subgroup, 9/35 (25.7%) patients were correctly assessed as not harboring pT(3) by imaging (ECE score <4), and would have allowed secure robot-assisted radical prostatectomy and nerve-sparing surgery (NSS). When T3 suspicion on preoperative MRI would be taken into account, intraoperative frozen-sections (IFS) might avoid positive SM in 12/18 high-risk patients and an oncologic secure NSS in 8/20 intermediate-risk patients. Prediction of pT(3) disease is crucial to plan NSS and to achieve negative SM in RP. Standardized ECE scoring on mpMRI is an independent predictor of pT(3) and may help to plan RP with oncologic security, even in high-risk patients. In addition, it allows more accurate selection of a subgroup of patients for systematic and MRI-guided IFS.

Comparison of sediment grain size characteristics on nourished and un-nourished estuarine beaches and impacts on horseshoe crab habitat, Delaware Bay, New Jersey

USGS Publications Warehouse

Jackson, N.L.; Smith, D.R.; Nordstrom, K.F.

2005-01-01

This study was undertaken to determine whether nourished and un-nourished estuarine beaches have conspicuous differences in sediment size and sorting that could affect their value as habitat for horseshoe crabs. Comparisons are made of beach profiles and sediment samples gathered at 0.15 m and 0.30 m depths on the backshore, at spring tide elevation, neap tide elevation, and the lower foreshore on 5 un-nourished and 3 nourished beaches in Delaware Bay, where tidal range is <2.0 m. The backshore is at least 0.5 m higher on the recently nourished beaches than on a nearby un-nourished beach reworked by storm waves. Nourishing these beaches to elevations higher than natural overwash heights will restrict natural evolution of the upper beach. Sediments at spring tide elevation on un-nourished sites average 0.72 mm in diameter at 0.15 m depth and 0.67 mm at 0.30 m depth.The similarity in size implies a relatively deep active layer in the zone of maximum cut and fill associated with cyclic profile change during low frequency, high magnitude storms. Sedimentary changes at neap tide elevation may be influenced more by depth of activation by waves than by cycles of deposition and erosion. Sediment at 0.15 m depth at spring and neap locations on the foreshore of nourished beaches is finer (0.51 mm) and better sorted (0.82 phi) than at 0.30 m depth (0.91 mm, 1.38 phi), implying that waves have not reworked the deeper sediments. Differences in sediment characteristics at depth may persist on eroding nourished beaches, where unreworked fill is close to the surface. Sediment texture influences horseshoe crab egg viability and development. Lower rates of water movement through the foreshore and greater thickness of the capillary fringe on nourished sites suggests that greater moisture retention will occur where horseshoe crabs bury eggs and may provide more favorable conditions for egg development, but the depth of these conditions will not be great on a recently nourished beach. ?? 2005 Gebru??der Borntraeger.

Delaware Technical & Community College's response to the critical shortage of Delaware secondary science teachers

NASA Astrophysics Data System (ADS)

Campbell, Nancy S.

This executive position paper examines the critical shortage of Delaware high school science teachers and Delaware Technical & Community College's possible role in addressing this shortage. A concise analysis of economic and political implications of the science teacher shortage is presented. The following topics were researched and evaluated: the specific science teacher needs for Delaware school districts; the science teacher education program offerings at Delaware universities and colleges; the Alternative Route to Teacher Certification (ARTC); and the state of Delaware's scholarship response to the need. Recommendations for Delaware Tech's role include the development and implementation of two new Associate of Arts of Teaching programs in physics secondary science education and chemistry secondary science education.

Nkx2.5 regulates Endothelin Converting Enzyme-1 during pharyngeal arch patterning

PubMed Central

Iklé, Jennifer M.; Tavares, Andre L. P.; King, Marisol; Ding, Hailei; Colombo, Sophie; Firulli, Beth A.; Firulli, Anthony B.; Targoff, Kimara L.; Yelon, Deborah; Clouthier, David E.

2017-01-01

In gnathostomes, dorsoventral (D-V) patterning of neural crest cells (NCC) within the pharyngeal arches is crucial for the development of hinged jaws. One of the key signals that mediates this process is Endothelin-1 (EDN1). Loss of EDN1 binding to the Endothelin-A receptor (EDNRA) results in loss of EDNRA signaling and subsequent facial birth defects in humans, mice and zebrafish. A rate-limiting step in this crucial signaling pathway is the conversion of immature EDN1 into a mature active form by Endothelin converting enzyme-1 (ECE1). However, surprisingly little is known about how Ece1 transcription is induced or regulated. We show here that Nkx2.5 is required for proper craniofacial development in zebrafish and acts in part by upregulating ece1 expression. Disruption of nkx2.5 in zebrafish embryos results in defects in both ventral and dorsal pharyngeal arch-derived elements, with changes in ventral arch gene expression consistent with a disruption in Ednra signaling. ece1 mRNA rescues the nkx2.5 morphant phenotype, indicating that Nkx2.5 functions through modulating Ece1 expression or function. These studies illustrate a new function for Nkx2.5 in embryonic development and provide new avenues with which to pursue potential mechanisms underlying human facial disorders. PMID:28109039

What's Happening with Computer Technology in Early Childhood Education Settings?

ERIC Educational Resources Information Center

Wood, Eileen; Willoughby, Teena; Specht, Jacqueline

1998-01-01

This in-depth survey of 75 early-childhood-education directors examined the current status of computer use in early childhood education (ECE). Results suggest that training may be necessary to facilitate the introduction of computers in ECE environments. (Author/LRW)

Factors that influence the efficiency of electrochemical chloride extraction during corrosion mitigation in reinforced concrete structures.

DOT National Transportation Integrated Search

2006-01-01

Electrochemical chloride extraction (ECE) is an electrochemical bridge restoration method for mitigating corrosion in reinforced concrete structures. ECE does this by moving chlorides away from the reinforcement and out of the concrete while simultan...

75 FR 33306 - Change in Bank Control Notices; Acquisition of Shares of Bank or Bank Holding Companies

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

...., a Delaware limited partnership; Tailwind Capital Partners (PP), L.P., a Delaware limited partnership; Tailwind Capital Partners, L.P., a Delaware limited partnership; Tailwind Capital Partners (ERISA), L.P., a Delaware limited partnership; Tailwind HSB Holdings, LLC, a Delaware limited liability company; Tailwind...

78 FR 25698 - Foreign-Trade Zone 99-Wilmington, Delaware; Application for Expansion of Subzone 99E; Delaware...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-02

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-38-2013] Foreign-Trade Zone 99--Wilmington, Delaware; Application for Expansion of Subzone 99E; Delaware City Refining Company LLC; New Castle County... (grantee of FTZ 99), through the Delaware Economic Development Office, requesting the expansion of Subzone...

78 FR 36658 - Safety Zone; Delaware River Waterfront Corp. Fireworks Display, Delaware River; Camden, NJ

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... portion of the Delaware River from operating while a fireworks event is taking place. This temporary...-AA00 Safety Zone; Delaware River Waterfront Corp. Fireworks Display, Delaware River; Camden, NJ AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary...

Effect of horseshoe crab spawning density on nest disturbance and exhumation of eggs: A simulation study

USGS Publications Warehouse

Smith, D.R.

2007-01-01

Because the Delaware Bay horseshoe crab (Limulus polyphemus) population is managed to provide for dependent species, such as migratory shorebirds, there is a need to understand the process of egg exhumation and to predict eggs available to foraging shorebirds. A simple spatial model was used to simulate horseshoe crab spawning that would occur on a typical Delaware Bay beach during spring tide cycles to quantify density-dependent nest disturbance. At least 20% of nests and eggs were disturbed for levels of spawning greater than one third of the average density in Delaware Bay during 2004. Nest disturbance increased approximately linearly as spawning density increased from one half to twice the 2004 level. As spawning density increased further, the percentage of eggs that were disturbed reached an asymptote of 70% for densities up to 10 times the density in 2004. Nest disturbance was heaviest in the mid beach zone. Nest disturbance precedes entrainment and begins the process of exhumation of eggs to surface sediments. Model predictions were combined with observations from egg surveys to estimate a snap-shot exhumation rate of 5-9% of disturbed eggs. Because an unknown quantity of eggs were exhumed and removed from the beach prior to the survey, cumulative exhumation rate was likely to have been higher than the snap-shot estimate. Because egg exhumation is density-dependent, in addition to managing for a high population size, identification and conservation of beaches where spawning horseshoe crabs concentrate in high densities (i.e., hot spots) are important steps toward providing a reliable food supply for migratory shorebirds. ?? 2007 Estuarine Research Federation.

Endothelin-converting Enzyme 1 and β-Arrestins Exert Spatiotemporal Control of Substance P-induced Inflammatory Signals*

PubMed Central

Jensen, Dane D.; Halls, Michelle L.; Murphy, Jane E.; Canals, Meritxell; Cattaruzza, Fiore; Poole, Daniel P.; Lieu, TinaMarie; Koon, Hon-Wai; Pothoulakis, Charalabos; Bunnett, Nigel W.

2014-01-01

Although the intracellular trafficking of G protein-coupled receptors controls specific signaling events, it is unclear how the spatiotemporal control of signaling contributes to complex pathophysiological processes such as inflammation. By using bioluminescence resonance energy transfer and superresolution microscopy, we found that substance P (SP) induces the association of the neurokinin 1 receptor (NK1R) with two classes of proteins that regulate SP signaling from plasma and endosomal membranes: the scaffolding proteins β-arrestin (βARRs) 1 and 2 and the transmembrane metallopeptidases ECE-1c and ECE-1d. In HEK293 cells and non-transformed human colonocytes, we observed that G protein-coupled receptor kinase 2 and βARR1/2 terminate plasma membrane Ca2+ signaling and initiate receptor trafficking to endosomes that is necessary for sustained activation of ERKs in the nucleus. βARRs deliver the SP-NK1R endosomes, where ECE-1 associates with the complex, degrades SP, and allows the NK1R, freed from βARRs, to recycle. Thus, both ECE-1 and βARRs mediate the resensitization of NK1R Ca2+ signaling at the plasma membrane. Sustained exposure of colonocytes to SP activates NF-κB and stimulates IL-8 secretion. This proinflammatory signaling is unaffected by inhibition of the endosomal ERK pathway but is suppressed by ECE-1 inhibition or βARR2 knockdown. Inhibition of protein phosphatase 2A, which also contributes to sustained NK1R signaling at the plasma membrane, similarly attenuates IL-8 secretion. Thus, the primary function of βARRs and ECE-1 in SP-dependent inflammatory signaling is to promote resensitization, which allows the sustained NK1R signaling from the plasma membrane that drives inflammation. PMID:24898255

Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling.

PubMed

Roosterman, Dirk; Cottrell, Graeme S; Padilla, Benjamin E; Muller, Laurent; Eckman, Christopher B; Bunnett, Nigel W; Steinhoff, Martin

2007-07-10

Neuropeptide signaling requires the presence of G protein-coupled receptors (GPCRs) at the cell surface. Activated GPCRs interact with beta-arrestins, which mediate receptor desensitization, endocytosis, and mitogenic signaling, and the peptide-receptor-arrestin complex is sequestered into endosomes. Although dissociation of beta-arrestins is required for receptor recycling and resensitization, the critical event that initiates this process is unknown. Here we report that the agonist availability in the endosomes, controlled by the membrane metalloendopeptidase endothelin-converting enzyme 1 (ECE-1), determines stability of the peptide-receptor-arrestin complex and regulates receptor recycling and resensitization. Substance P (SP) binding to the tachykinin neurokinin 1 receptor (NK1R) induced membrane translocation of beta-arrestins followed by trafficking of the SP-NK1R-beta-arrestin complex to early endosomes containing ECE-1a-d. ECE-1 degraded SP in acidified endosomes, disrupting the complex; beta-arrestins returned to the cytosol, and the NK1R, freed from beta-arrestins, recycled and resensitized. An ECE-1 inhibitor, by preventing NK1R recycling in endothelial cells, inhibited resensitization of SP-induced inflammation. This mechanism is a general one because ECE-1 similarly regulated NK3R resensitization. Thus, peptide availability in endosomes, here regulated by ECE-1, determines the stability of the peptide-receptor-arrestin complex. This mechanism regulates receptor recycling, which is necessary for sustained signaling, and it may also control beta-arrestin-dependent mitogenic signaling of endocytosed receptors. We propose that other endosomal enzymes and transporters may similarly control the availability of transmitters in endosomes to regulate trafficking and signaling of GPCRs. Antagonism of these endosomal processes represents a strategy for inhibiting sustained signaling of receptors, and defects may explain the tachyphylaxis of drugs that are receptor agonists.

Endothelin-converting enzyme-1 degrades internalized somatostatin-14.

PubMed

Roosterman, Dirk; Kempkes, Cordula; Cottrell, Graeme S; Padilla, Benjamin E; Bunnett, Nigel W; Turck, Christoph W; Steinhoff, Martin

2008-05-01

Agonist-induced internalization of somatostatin receptors (ssts) determines subsequent cellular responsiveness to peptide agonists and influences sst receptor scintigraphy. To investigate sst2A trafficking, rat sst2A tagged with epitope was expressed in human embryonic kidney cells and tracked by antibody labeling. Confocal microscopical analysis revealed that stimulation with sst and octreotide induced internalization of sst2A. Internalized sst2A remained sequestrated within early endosomes, and 60 min after stimulation, internalized sst2A still colocalized with beta-arrestin1-enhanced green fluorescence protein (EGFP), endothelin-converting enzyme-1 (ECE-1), and rab5a. Internalized (125)I-Tyr(11)-SST-14 was rapidly hydrolyzed by endosomal endopeptidases, with radioactive metabolites being released from the cell. Internalized (125)I-Tyr(1)-octreotide accumulated as an intact peptide and was released from the cell as an intact peptide ligand. We have identified ECE-1 as one of the endopeptidases responsible for inactivation of internalized SST-14. ECE-1-mediated cleavage of SST-14 was inhibited by the specific ECE-1 inhibitor, SM-19712, and by preventing acidification of endosomes using bafilomycin A(1). ECE-1 cleaved SST-14 but not octreotide in an acidic environment. The metallopeptidases angiotensin-1 converting enzyme and ECE-2 did not hydrolyze SST-14 or octreotide. Our results show for the first time that stimulation with SST-14 and octreotide induced sequestration of sst2A into early endosomes and that endocytosed SST-14 is degraded by endopeptidases located in early endosomes. Furthermore, octreotide was not degraded by endosomal peptidases and was released as an intact peptide. This mechanism may explain functional differences between octreotide and SST-14 after sst2A stimulation. Moreover, further investigation of endopeptidase-regulated trafficking of neuropeptides may result in novel concepts of neuropeptide receptor inactivation in cancer diagnosis.

New Developments

ERIC Educational Resources Information Center

Lohmander, Maelis Karlson; Vandenbroeck, Michel; Pirard, Florence; Peeters, Jan; Alvestad, Marit

2009-01-01

New developments and challenges regarding early childhood education (ECE) policy and practice in Norway and in the Flemish and French communities in Belgium are presented in this issue. There are clear differences between the countries when comparing systems they have chosen for ECE. In Belgium, supervision and responsibilities for education,…

Engineering aspects of design and integration of ECE diagnostic in ITER

DOE PAGES

Udintsev, V. S.; Taylor, G.; Pandya, H. K.B.; ...

2015-03-12

ITER ECE diagnostic [1] needs not only to meet measurement requirements, but also to withstand various loads, such as electromagnetic, mechanical, neutronic and thermal, and to be protected from stray ECH radiation at 170 GHz and other millimeter wave emission, like Collective Thomson scattering which is planned to operate at 60 GHz. Same or similar loads will be applied to other millimetre-wave diagnostics [2], located both in-vessel and in-port plugs. These loads must be taken into account throughout the design phases of the ECE and other microwave diagnostics to ensure their structural integrity and maintainability. The integration of microwave diagnosticsmore » with other ITER systems is another challenging activity which is currently ongoing through port integration and in-vessel integration work. Port Integration has to address the maintenance and the safety aspects of diagnostics, too. Engineering solutions which are being developed to support and to operate ITER ECE diagnostic, whilst complying with safety and maintenance requirements, are discussed in this paper.« less

Temperature induced phase transformations and negative electrocaloric effect in (Pb,La)(Zr,Sn,Ti)O3 antiferroelectric single crystal

NASA Astrophysics Data System (ADS)

Zhuo, Fangping; Li, Qiang; Yan, Qingfeng; Zhang, Yiling; Wu, Hong-Hui; Xi, Xiaoqing; Chu, Xiangcheng; Cao, Wenwu

2017-10-01

Temperature induced phase transitions and electrocaloric effect (ECE) of (Pb,La)(Zr,Sn,Ti)O3 (PLZST) single crystals have been comprehensively studied. Based on the in situ evolution of domain structures and dielectric properties of the PLZST crystals, the phase transitions during heating are in the sequence of orthorhombic antiferroelectric → rhombohedral ferroelectric → cubic paraelectric. Coexistence of the negative and positive ECEs has been achieved in the PLZST single crystals. A negative ECE value of -1.26 °C and enhanced electrocaloric strength of -0.21 K mm/kV near the Curie temperature have been obtained. A modified Landau model gives a satisfactory description of the experimentally observed unusual ECE. Moreover, a temperature-electric field phase diagram is also established based on theoretical analysis. Our results will help people understand better the electrocaloric family, particularly on the negative and/or positive effect in antiferroelectrics and ferroelectrics.

Pre-Service Teachers' Perceptions on Tpack Development after Designing Educational Games

ERIC Educational Resources Information Center

Sancar Tokmak, Hatice

2015-01-01

This qualitative case study aimed to investigate Early Childhood Education (ECE) pre-service teachers' perception of development in their technological, pedagogical, content knowledge (TPACK) after designing educational computer games for young children. Participants included 21 ECE pre-service teachers enrolled in the course Instructional…

Colossal Room-Temperature Electrocaloric Effect in Ferroelectric Polymer Nanocomposites Using Nanostructured Barium Strontium Titanates.

PubMed

Zhang, Guangzu; Zhang, Xiaoshan; Yang, Tiannan; Li, Qi; Chen, Long-Qing; Jiang, Shenglin; Wang, Qing

2015-07-28

The electrocaloric effect (ECE) refers to conversion of thermal to electrical energy of polarizable materials and could form the basis for the next-generation refrigeration and power technologies that are highly efficient and environmentally friendly. Ferroelectric materials such as ceramic and polymer films exhibit large ECEs, but each of these monolithic materials has its own limitations for practical cooling applications. In this work, nanosized barium strontium titanates with systematically varied morphologies have been prepared to form polymer nanocomposites with the ferroelectric polymer matrix. The solution-processed polymer nanocomposites exhibit an extraordinary room-temperature ECE via the synergistic combination of the high breakdown strength of a ferroelectric polymer matrix and the large change of polarization with temperature of ceramic nanofillers. It is found that a sizable ECE can be generated under both modest and high electric fields, and further enhanced greatly by tailoring the morphology of the ferroelectric nanofillers such as increasing the aspect ratio of the nanoinclusions. The effect of the geometry of the nanofillers on the dielectric permittivity, polarization, breakdown strength, ECE and crystallinity of the ferroelectric polymer has been systematically investigated. Simulations based on the phase-field model have been carried out to substantiate the experimental results. With the remarkable cooling energy density and refrigerant capacity, the polymer nanocomposites are promising for solid-state cooling applications.

Detecting non-maxwellian electron velocity distributions at JET by high resolution Thomson scattering.

PubMed

Beausang, K V; Prunty, S L; Scannell, R; Beurskens, M N; Walsh, M J; de la Luna, E

2011-03-01

The present work is motivated by a long standing discrepancy between the electron temperature measurements of Thomson scattering (TS) and electron cyclotron emission (ECE) diagnostics for plasmas with strong auxiliary heating observed at both JET and TFTR above 6–7 keV, where in some cases the ECE electron temperature measurements can be 15%–20% higher than the TS measurements. Recent analysis based on ECE results at JET has shown evidence of distortions to the Maxwellian electron velocity distribution and a correlation with the TS and ECE discrepancies has been suggested. In this paper, a technique to determine the presence of non-Maxwellian behavior using TS diagnostics is outlined. The difficulties and limitations of modern TS system designs to determine the electron velocity distribution are also discussed. It is demonstrated that small deviations such as those suggested by previous ECE analysis could be potentially detected, depending on the spectral layout of the TS polychromators. The spectral layout of the JET high resolution Thomson scattering system is such that it could be used to determine these deviations between 1 and 6 keV, and the results presented here indicate that no evidence of non-Maxwellian behavior is observed in this range. In this paper, a modification to the current polychromator design is proposed, allowing non-Maxwellian distortions to be detected up to at least 10 keV.

Effects of mechanical deformation on energy conversion efficiency of piezoelectric nanogenerators.

PubMed

Yoo, Jinho; Cho, Seunghyeon; Kim, Wook; Kwon, Jang-Yeon; Kim, Hojoong; Kim, Seunghyun; Chang, Yoon-Suk; Kim, Chang-Wan; Choi, Dukhyun

2015-07-10

Piezoelectric nanogenerators (PNGs) are capable of converting energy from various mechanical sources into electric energy and have many attractive features such as continuous operation, replenishment and low cost. However, many researchers still have studied novel material synthesis and interfacial controls to improve the power production from PNGs. In this study, we report the energy conversion efficiency (ECE) of PNGs dependent on mechanical deformations such as bending and twisting. Since the output power of PNGs is caused by the mechanical strain of the piezoelectric material, the power production and their ECE is critically dependent on the types of external mechanical deformations. Thus, we examine the output power from PNGs according to bending and twisting. In order to clearly understand the ECE of PNGs in the presence of those external mechanical deformations, we determine the ECE of PNGs by the ratio of output electrical energy and input mechanical energy, where we suggest that the input energy is based only on the strain energy of the piezoelectric layer. We calculate the strain energy of the piezoelectric layer using numerical simulation of bending and twisting of the PNG. Finally, we demonstrate that the ECE of the PNG caused by twisting is much higher than that caused by bending due to the multiple effects of normal and lateral piezoelectric coefficients. Our results thus provide a design direction for PNG systems as high-performance power generators.

Active Early: one-year policy intervention to increase physical activity among early care and education programs in Wisconsin.

PubMed

LaRowe, Tara L; Tomayko, Emily J; Meinen, Amy M; Hoiting, Jill; Saxler, Courtney; Cullen, Bridget

2016-07-20

Early childcare and education (ECE) is a prime setting for obesity prevention and the establishment of healthy behaviors. The objective of this quasi-experimental study was to examine the efficacy of the Active Early guide, which includes evidenced-based approaches, provider resources, and training, to improve physical activity opportunities through structured (i.e. teacher-led) activity and environmental changes thereby increasing physical activity among children, ages 2-5 years, in the ECE setting. Twenty ECE programs in Wisconsin, 7 family and 13 group, were included. An 80-page guide, Active Early, was developed by experts and statewide partners in the fields of ECE, public health, and physical activity and was revised by ECE providers prior to implementation. Over 12 months, ECE programs received on-site training and technical assistance to implement the strategies and resources provided in the Active Early guide. Main outcome measures included observed minutes of teacher-led physical activity, physical activity environment measured by the Environment and Policy Assessment and Observation (EPAO) instrument, and child physical activity levels via accelerometry. All measures were collected at baseline, 6 months, and 12 months and were analyzed for changes over time. Observed teacher-led physical activity significantly increased from 30.9 ± 22.7 min at baseline to 82.3 ± 41.3 min at 12 months. The change in percent time children spent in sedentary activity decreased significantly after 12 months (-4.4 ± 14.2 % time, -29.2 ± 2.6 min, p < 0.02). Additionally, as teacher led-activity increased, percent time children were sedentary decreased (r = -0.37, p < 0.05) and percent time spent in light physical activity increased (r = 0.35, p < 0.05). Among all ECE programs, the physical activity environment improved significantly as indicated by multiple sub-scales of the EPAO; scores showing the greatest increases were the Training and Education (14.5 ± 6.5 at 12-months vs. 2.4 ± 3.8 at baseline, p < 0.01) and Physical Activity Policy (18.6 ± 4.6 at 12-months vs. 2.0 ± 4.1 at baseline, p < 0.01). Active Early promoted improvements in providing structured (i.e. teacher-led) physical activity beyond the recommended 60 daily minutes using low- to no-cost strategies along with training and environmental changes. Furthermore, it was observed that Active Early positively impacted child physical activity levels by the end of the intervention. However, resources, training, and technical assistance may be necessary for ECE programs to be successful beyond the use of the Active Early guide. Implementing local-level physical activity policies combined with support from local and statewide partners has the potential to influence higher standards for regulated ECE programs.

Playing the Assessment Game: An English Early Childhood Education Perspective

ERIC Educational Resources Information Center

Basford, Jo; Bath, Caroline

2014-01-01

Assessment and the documentation of learning is an international issue in early childhood education (ECE) and has increasingly become a way for governments to exercise direct control over the practitioners working with young children. This paper details recent statutory guidance about assessment and documentation for English ECE settings and…

Building Capacity through an Early Education Leadership Academy

ERIC Educational Resources Information Center

Goffin, Stacie G.

2013-01-01

In 2013, the early childhood education (ECE) field is paying limited attention to leadership development (Goffin & Janke, 2013; Goffin & Means, 2009). A recent survey of ECE leadership development programs suggests that the field does not fully recognize the potential of leadership to serve as a change catalyst, although there is evidence…

Language Arts: Exceptional Child Education Curriculum K-12.

ERIC Educational Resources Information Center

Curran, Teresa; And Others

The Exceptional Child Education (ECE) program of Jefferson County Public Schools in Louisville, Kentucky, presents this language arts curriculum for use with K-12 students who have learning problems. The ECE program uses the curriculum and materials of the general education program whenever appropriate, but has access to special instructional…

Constructing Relational Space in Early Childhood Education

ERIC Educational Resources Information Center

Vuorisalo, Mari; Rutanen, Niina; Raittila, Raija

2015-01-01

This paper examines early childhood education (ECE) by applying and developing relational-spatial perspectives on everyday life in educational institutions for young children. The aim is to investigate the dynamic process of construction of space and to illustrate with selected empirical episodes how this process occurs in ECE. Drawing on authors…

1. NORTHWEST OBLIQUE AERIAL VIEW OF FORT DELAWARE AND PEA ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. NORTHWEST OBLIQUE AERIAL VIEW OF FORT DELAWARE AND PEA PATCH ISLAND. REMAINS OF SEA WALL VISIBLE IN FOREGROUND AND RIGHT OF IMAGE. - Fort Delaware, Sea Wall, Pea Patch Island, Delaware City, New Castle County, DE

DELAWARE ESTUARY A MANAGEMENT PLAN FOR THE DELAWARE ESTUARY

EPA Science Inventory

Wise conservation and management of the Delaware Estuary is arguably the most important cooperative environmental initiative ever jointly undertaken by the States of New Jersey, Pennsylvania, and Delaware. While much has been accomplished over the past few decades to improve wate...

Early Childhood Educators' Understanding of Early Communication: Application to Their Work with Young Children

ERIC Educational Resources Information Center

Brebner, Chris; Jovanovic, Jessie; Lawless, Angela; Young, Jessica

2016-01-01

Young children need rich learning experiences to maximize their potential. Early childhood educators (ECEs) working in childcare have knowledge of individual children as well as skills and professional knowledge that afford opportunities to provide language-rich environments for learning. To successfully work in partnership with ECEs,…

Canadian Early-Childhood Educators' Perceptions of Children's Gendered Shy, Aggressive, and Prosocial Behaviors

ERIC Educational Resources Information Center

Woods, Heather; Bosacki, Sandra; Coplan, Robert J.

2016-01-01

Early childhood educators' (ECE) perceptions of gender roles may contribute to the development of children's own gender-role identities. This qualitative study examined 40 Canadian female ECEs' perceptions of gender and children's shy, aggressive, and prosocial behaviors. Content analysis of extensive interviews revealed three themes: (1) shyness…

The Influence of Gender Bias on Children in Childcare Settings

ERIC Educational Resources Information Center

Ikram, R

2011-01-01

To date, Early Childhood Education (ECE) courses and curriculum are primarily focused on a being gender neutral and teaching non-traditional gender practices in childcare settings. Further, many child care providers, specifically ECE teachers, are women. This paper describes how many teachers in childcare settings are teaching boys and girls to…

Brokering to Support Participation of Disadvantaged Families in Early Childhood Education

ERIC Educational Resources Information Center

Mitchell, Linda; Meagher-Lundberg, Patricia

2017-01-01

This paper discusses findings from an evaluation of the New Zealand Ministry of Education's Early Childhood Education (ECE) Participation Programme that targeted local areas where there are high numbers of children starting school who have not participated in ECE. The aim of the programme is to increase participation of these low-income…

Praxis in Early Childhood Research with Infants and Educators

ERIC Educational Resources Information Center

Salamon, Andi

2017-01-01

As emerging literature reflects, "praxis" is an important and useful concept for thinking about the many aspects of early childhood education (ECE) and early childhood research. In this article, I seek to contribute to discussions about praxis in ECE as a valuable concept for meeting the ethical challenges that arise in participatory…

Examining Quality in Two Preschool Settings: Publicly Funded Early Childhood Education and Inclusive Early Childhood Education Classrooms

ERIC Educational Resources Information Center

Pelatti, Christina Yeager; Dynia, Jaclyn M.; Logan, Jessica A.; Justice, Laura M.; Kaderavek, Joan

2016-01-01

Background: Although classroom quality is an important consideration, few recent research studies have examined the process and structural quality in publicly funded early childhood education (ECE) and inclusive ECE classrooms. This study provides an important contribution to the literature by comparing two conceptualizations of quality in…

The Eros of Counter Education

ERIC Educational Resources Information Center

Luzon, Pinhas

2016-01-01

Erotic Counter Education (ECE) is the educational position of the late Ilan Gur-Ze'ev. In ECE Gur-Ze'ev combines two opposing positions in the philosophy of education, one teleological and anti-utopian, the other teleological and utopian. In light of this unique combination, I ask what mediates between these two poles and suggest that the answer…

Homophobia, Sexism, and Early Childhood Education: A Review of the Literature

ERIC Educational Resources Information Center

Duke, Thomas Scott; McCarthy, Kathrin W.

2009-01-01

We reviewed 31 articles that explored issues related to gender and sexuality in early childhood education (ECE) settings. This body of literature suggests that ECE programs and elementary schools often reinforce the homophobia, heterosexism, and sexism that characterize contemporary U.S. society. A number of the articles described strategies that…

Electronic Continuing Education in the Health Professions: An Update on Evidence from RCTs

ERIC Educational Resources Information Center

Lam-Antoniades, Margarita; Ratnapalan, Savithiri; Tait, Gordon

2009-01-01

Introduction: Demonstrating the effectiveness of the rapidly expanding field of electronic continuing education (e-CE) has important implications for CE in the health professions. This study provides an update on evidence from randomized controlled trials (RCTs) assessing the effectiveness of e-CE in the health professions. Methods: A literature…

Early Childhood Education in Eighteen Countries in the Middle East and North Africa.

ERIC Educational Resources Information Center

Khattab, Mohammad S.

1996-01-01

Examined the status of early childhood education (ECE) in 18 middle eastern and north African countries, incorporating country profiles, ECE institutions, teachers, and children. Identified the critical issues needing priority attention, and a set of indicators that could be used by educational planners and policymakers for monitoring and…

Disarming Contankerous People: Coping with Difficult Personalities in ECE Work Settings

ERIC Educational Resources Information Center

Hernandez, Luis; Smith, Connie Jo

2009-01-01

Difficult personalities come in a variety of roles in just about every setting. While types have been identified in the typical corporate and business culture, difficult work personalities also inhabit the world of early childhood education (ECE) workplaces. Because difficult people have an impact on workplace morale and productivity, the topic…

Shared-Reading Volume in Early Childhood Special Education Classrooms

ERIC Educational Resources Information Center

Dynia, Jaclyn M.; Justice, Laura M.

2015-01-01

This study describes book reading practices occurring in early childhood special education (ECSE) classrooms in comparison to early childhood education (ECE) classrooms. Reading logs submitted by 19 ECSE teachers and 13 ECE teachers over one academic year included all books read in whole class settings; these logs were analyzed to assess the…

Experienced Early Childhood Teachers as Graduate Students: A Process of Change

ERIC Educational Resources Information Center

Mevorach, Miriam; Miron, Mordechai

2011-01-01

This paper explores perceptions of professional identity among experienced early childhood educators (ECEs) who are novice students in a new master's degree program in ECE. We sought to examine the changes experienced by these educators. The study used qualitative content analysis, which included an open-ended questionnaire that was administered…

Financing the Early Childhood Education System: NAEYC Policy Brief.

ERIC Educational Resources Information Center

Young Children, 2001

2001-01-01

Discusses the view of the National Association for the Education of Young Children (NAEYC) regarding financing a system of early childhood education (ECE) in every state and community. Considers how to create a system, why financing is so important, the need to finance ECE programs and infrastructure, and various financing mechanisms. Concludes…

Challenges in Implementation of Early Childhood Education in Nigeria: The Way Forward

ERIC Educational Resources Information Center

Akinrotimi, Adenike A.; Olowe, Peter K.

2016-01-01

Early Childhood Education (ECE) comprises essential programmes and activities which are critical to holistic development, academic success and future achievements of children. ECE is recognised by the federal government of Nigeria as a foundational and essential programme that Nigerian children must experience. This is why the government has given…

Ways of dealing with science learning: a study based on Swedish early childhood education practice

NASA Astrophysics Data System (ADS)

Gustavsson, Laila; Jonsson, Agneta; Ljung-Djärf, Agneta; Thulin, Susanne

2016-07-01

The Swedish school system offers curriculum-based early childhood education (ECE) organised as preschool (for 0-5-year-olds) and preschool class (for 6-year-olds). The intention to create a playful and educational environment based on children's perspectives, interests, and questions is strongly based on historical and cultural traditions. This article develops knowledge of ECE teachers' approaches to science-learning situations. The study applies a phenomenographic approach. The analysis is based on approximately 9.5 hours of video documentation of teacher-led and child-initiated Swedish ECE science activities. We identified two descriptive categories and four subcategories dealing with science-learning situations: (A) making anything visible, containing the three subcategories (Aa) addressing everyone, (Ab) addressing everything, and (Ac) addressing play and fantasy; and (B) creating a shared space for learning (Ba) addressing common content. These categories are related to how efforts to take advantage of children's perspectives are interpreted and addressed in educational practice. The article discusses and exemplifies the use of various categories and their potential implications for ECE learning practice.

Ideal kink and neoclassical tearing mode identification in DIII-D with ECE

NASA Astrophysics Data System (ADS)

Zhao, Hailin; Austin, Max; Brookman, Michale; Rowan, William; La Haye, R. J.

2017-10-01

Detection of neoclassical tearing modes (NTMs), which can degrade plasma confinement or cause disruptions, is important in tokamaks. We have developed a code to cross-correlate ECE/magnetics data to get the amplitude and phase profiles of the electron temperature (Te) oscillation caused by the rotating magnetic island and/or a kink. It has been observed that the ΔTe amplitude on the two sides of the island center can be very different in some discharges. Also, a discrepancy often exists between the location of the rational q surface according to MSE-constrained EFIT and the location of island center according to ECE; this can be an issue for ECCD suppression of NTMs. We explore the possible causes of these two phenomena in terms of ECE location and calibration accuracy. By analyzing the Te fluctuation phase evolution after a large sawtooth crash which triggers an NTM, the presence of a kink-like mode before the onset of NTM can be discerned. Work supported by the US DOE under DE-FG02-97ER54415 and DE-FC02-04ER54698.

Enhanced electrocaloric effect in displacive-type organic ferroelectrics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ding, L. J., E-mail: dinglinjie82@126.com; Zhong, Y.; Fan, S. W.

2015-08-07

We explore the intrinsic feature of electrocaloric effect (ECE) accompanied by ferroelectric (FE)-paraelectric (PE) transition for displacive-type organic ferroelectrics using Green's function theory. It is demonstrated that decreasing elastic constant K or increasing spin-lattice coupling λ can enhance the ECE, as well as polarization P and transition temperature T{sub C}. Indeed, one expects that the optimal operating temperature for solid-state refrigeration is around room temperature, at which the ECE achieves its maximum. As T{sub C} is tuned to ∼310 K, it presents larger ECE response and remanent polarization with lower coercive field for smaller K value, suggesting that well flexible displacive-typemore » organic ferroelectrics are excellent candidates both for electric cooling and data storage in the design of nonvolatile FE random-access memories. Furthermore, in an electric field, it provides a bridge between a Widom line that denotes FE-PE crossover above T{sub C} and a metaelectric transition line below T{sub C} that demonstrates an FE switching behavior with an antiparallel field.« less

Giant electrocaloric effect in a cracked ferroelectrics

NASA Astrophysics Data System (ADS)

Huang, Cheng; Yang, Hai-Bing; Gao, Cun-Fa

2018-04-01

The electrocaloric effect (ECE) is the temperature change in a material induced by electrical field variation under adiabatic condition. Considering an external electric load applied on a cracked ferroelectric solid, a non-uniform electric field would be induced at the crack tip, and thus, incompatible strain field and local stress concentration would be generated around it. Furthermore, the enormous strain energy and the electrostatic energy would affect the polarization switching of the ferroelectric solid, important for the electrocaloric response. In this paper, the large negative and positive ECEs in a ferroelectric sheet with a conducting crack are investigated by the phase field method with the consideration of time-dependent Ginzburg-Landau equation. The numerical calculations indicated that the polarization field generates a sharp rise during the domain transition from polydomain to monodomain under a certain electric load. Large negative ECEs, about -10.21 K and -7.55 K, are obtained at 135 °C and 85 °C, respectively. The domain transition temperature is much lower than the Curie temperature, which enlarges the existence scope of the large ECE in ferroelectrics. The results also imply that the domain transition from a multi-domain state to a single domain takes place with the minimization of total free energy, which involves the courses of the electric field, stress field, temperature, and polarization interaction. Therefore, the non-uniform distributions of the stress-electric fields induced by the crack play an important role in ECE.

78 FR 14060 - Television Broadcasting Services; Seaford, Delaware and Dover, Delaware

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-04

... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 [MB Docket No. 13-40, RM-11691; DA 13-160] Television Broadcasting Services; Seaford, Delaware and Dover, Delaware AGENCY: Federal Communications...: Federal Communications Commission, Office of the Secretary, 445 12th Street SW., Washington, DC 20554. In...

Delaware's Dream Team

ERIC Educational Resources Information Center

Berry, John N., III

2007-01-01

To librarians at the Delaware Division of Libraries, Governor Ruth Ann Minner, Secretary of State Harriet Smith Windsor, and Assistant Secretary of State Rick Geisenberger are "the Delaware Dream Team." The governor and her team supported funding for the 2004 statewide effort that resulted in the Delaware Master Plan for Library Services…

Novel single-cell mega-size chambers for electrochemical etching of panorama position-sensitive polycarbonate ion image detectors

NASA Astrophysics Data System (ADS)

Sohrabi, Mehdi

2017-11-01

A novel development is made here by inventing panorama single-cell mega-size electrochemical etching (MS-ECE) chamber systems for processing panorama position-sensitive mega-size polycarbonate ion image detectors (MS-PCIDs) of potential for many neutron and ion detection applications in particular hydrogen ions or proton tracks and images detected for the first time in polycarbonates in this study. The MS-PCID is simply a large polycarbonate sheet of a desired size. The single-cell MS-ECE invented consists of two large equally sized transparent Plexiglas sheets as chamber walls holding a MS-PCID and the ECE chamber components tightly together. One wall has a large flat stainless steel electrode (dry cell) attached to it which is directly in contact with the MS-PCID and the other wall has a rod electrode with two holes to facilitate feeding and draining out the etching solution from the wet cell. A silicon rubber washer plays the role of the wet cell to hold the etchant and the electrical insulator to isolate the dry cell from the wet cell. A simple 50 Hz-HV home-made generator provides an adequate field strength through the two electrodes across the MS-ECE chamber. Two panorama single-cell MS-ECE chamber systems (circular and rectangular shapes) constructed were efficiently applied to processing the MS-PCIDs for 4π ion emission image detection of different gases in particular hydrogen ions or protons in a 3.5 kJ plasma focus device (PFD as uniquely observed by the unaided eyes). The panorama MS-PCID/MS-ECE image detection systems invented are novel with high potential for many applications in particular as applied to 4π panorama ion emission angular distribution image detection studies in PFD space, some results of which are presented and discussed.

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals.

PubMed

Jensen, Dane D; Halls, Michelle L; Murphy, Jane E; Canals, Meritxell; Cattaruzza, Fiore; Poole, Daniel P; Lieu, TinaMarie; Koon, Hon-Wai; Pothoulakis, Charalabos; Bunnett, Nigel W

2014-07-18

Although the intracellular trafficking of G protein-coupled receptors controls specific signaling events, it is unclear how the spatiotemporal control of signaling contributes to complex pathophysiological processes such as inflammation. By using bioluminescence resonance energy transfer and superresolution microscopy, we found that substance P (SP) induces the association of the neurokinin 1 receptor (NK1R) with two classes of proteins that regulate SP signaling from plasma and endosomal membranes: the scaffolding proteins β-arrestin (βARRs) 1 and 2 and the transmembrane metallopeptidases ECE-1c and ECE-1d. In HEK293 cells and non-transformed human colonocytes, we observed that G protein-coupled receptor kinase 2 and βARR1/2 terminate plasma membrane Ca(2+) signaling and initiate receptor trafficking to endosomes that is necessary for sustained activation of ERKs in the nucleus. βARRs deliver the SP-NK1R endosomes, where ECE-1 associates with the complex, degrades SP, and allows the NK1R, freed from βARRs, to recycle. Thus, both ECE-1 and βARRs mediate the resensitization of NK1R Ca(2+) signaling at the plasma membrane. Sustained exposure of colonocytes to SP activates NF-κB and stimulates IL-8 secretion. This proinflammatory signaling is unaffected by inhibition of the endosomal ERK pathway but is suppressed by ECE-1 inhibition or βARR2 knockdown. Inhibition of protein phosphatase 2A, which also contributes to sustained NK1R signaling at the plasma membrane, similarly attenuates IL-8 secretion. Thus, the primary function of βARRs and ECE-1 in SP-dependent inflammatory signaling is to promote resensitization, which allows the sustained NK1R signaling from the plasma membrane that drives inflammation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Endothelin-Converting Enzyme-1 Degrades Internalized Somatostatin-14

PubMed Central

Roosterman, Dirk; Kempkes, Cordula; Cottrell, Graeme S.; Padilla, Benjamin E.; Bunnett, Nigel W.; Turck, Christoph W.; Steinhoff, Martin

2008-01-01

Agonist-induced internalization of somatostatin receptors (ssts) determines subsequent cellular responsiveness to peptide agonists and influences sst receptor scintigraphy. To investigate sst2A trafficking, rat sst2A tagged with epitope was expressed in human embryonic kidney cells and tracked by antibody labeling. Confocal microscopical analysis revealed that stimulation with sst and octreotide induced internalization of sst2A. Internalized sst2A remained sequestrated within early endosomes, and 60 min after stimulation, internalized sst2A still colocalized with β-arrestin1-enhanced green fluorescence protein (EGFP), endothelin-converting enzyme-1 (ECE-1), and rab5a. Internalized 125I-Tyr11-SST-14 was rapidly hydrolyzed by endosomal endopeptidases, with radioactive metabolites being released from the cell. Internalized 125I-Tyr1-octreotide accumulated as an intact peptide and was released from the cell as an intact peptide ligand. We have identified ECE-1 as one of the endopeptidases responsible for inactivation of internalized SST-14. ECE-1-mediated cleavage of SST-14 was inhibited by the specific ECE-1 inhibitor, SM-19712, and by preventing acidification of endosomes using bafilomycin A1. ECE-1 cleaved SST-14 but not octreotide in an acidic environment. The metallopeptidases angiotensin-1 converting enzyme and ECE-2 did not hydrolyze SST-14 or octreotide. Our results show for the first time that stimulation with SST-14 and octreotide induced sequestration of sst2A into early endosomes and that endocytosed SST-14 is degraded by endopeptidases located in early endosomes. Furthermore, octreotide was not degraded by endosomal peptidases and was released as an intact peptide. This mechanism may explain functional differences between octreotide and SST-14 after sst2A stimulation. Moreover, further investigation of endopeptidase-regulated trafficking of neuropeptides may result in novel concepts of neuropeptide receptor inactivation in cancer diagnosis. PMID:18276747

Novel single-cell mega-size chambers for electrochemical etching of panorama position-sensitive polycarbonate ion image detectors.

PubMed

Sohrabi, Mehdi

2017-11-01

A novel development is made here by inventing panorama single-cell mega-size electrochemical etching (MS-ECE) chamber systems for processing panorama position-sensitive mega-size polycarbonate ion image detectors (MS-PCIDs) of potential for many neutron and ion detection applications in particular hydrogen ions or proton tracks and images detected for the first time in polycarbonates in this study. The MS-PCID is simply a large polycarbonate sheet of a desired size. The single-cell MS-ECE invented consists of two large equally sized transparent Plexiglas sheets as chamber walls holding a MS-PCID and the ECE chamber components tightly together. One wall has a large flat stainless steel electrode (dry cell) attached to it which is directly in contact with the MS-PCID and the other wall has a rod electrode with two holes to facilitate feeding and draining out the etching solution from the wet cell. A silicon rubber washer plays the role of the wet cell to hold the etchant and the electrical insulator to isolate the dry cell from the wet cell. A simple 50 Hz-HV home-made generator provides an adequate field strength through the two electrodes across the MS-ECE chamber. Two panorama single-cell MS-ECE chamber systems (circular and rectangular shapes) constructed were efficiently applied to processing the MS-PCIDs for 4π ion emission image detection of different gases in particular hydrogen ions or protons in a 3.5 kJ plasma focus device (PFD as uniquely observed by the unaided eyes). The panorama MS-PCID/MS-ECE image detection systems invented are novel with high potential for many applications in particular as applied to 4π panorama ion emission angular distribution image detection studies in PFD space, some results of which are presented and discussed.

77 FR 53226 - Final Environmental Impact Statement for the Susquehanna to Roseland 500-kilovolt Transmission...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

... National Scenic Trail; Delaware Water Gap National Recreation Area and Middle Delaware National Scenic and... pass through three units of the National Park System: The Appalachian National Scenic Trail, Delaware.... SUPPLEMENTARY INFORMATION: The Appalachian National Scenic Trail, Delaware Water Gap National Recreation Area...

40 CFR 81.15 - Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware).

Code of Federal Regulations, 2010 CFR

2010-07-01

... Air Quality Control Region (Pennsylvania-New Jersey-Delaware). 81.15 Section 81.15 Protection of... Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware). The Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware) consists of the territorial area...

78 FR 22785 - Approval and Promulgation of Air Quality Implementation Plans; Delaware, State Board Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-17

... Promulgation of Air Quality Implementation Plans; Delaware, State Board Requirements AGENCY: Environmental... revision to the Delaware State Implementation Plan (SIP) submitted by the Delaware Department of Natural Resources and Environmental Control (DNREC) on January 11, 2013. The SIP revision addresses requirements of...

40 CFR 81.55 - Northeast Pennsylvania-Upper Delaware Valley Interstate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Northeast Pennsylvania-Upper Delaware... Designation of Air Quality Control Regions § 81.55 Northeast Pennsylvania-Upper Delaware Valley Interstate Air Quality Control Region. The Northeast Pennsylvania-Upper Delaware Valley Interstate Air Quality Control...

78 FR 59821 - Safety Zone, Delaware River; Wilmington, DE

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

... 1625-AA00 Safety Zone, Delaware River; Wilmington, DE AGENCY: Coast Guard, DHS. ACTION: Temporary final... safety zone will encompass all waters of Deepwater Anchorage No. 6, Delaware River, Wilmington, DE from... navigable waters of Deepwater Point Anchorage No. 6, Delaware River, Wilmington, DE, the effect of this...

Tying Early Childhood Education More Closely to Schooling: Promise, Perils and Practical Problems

ERIC Educational Resources Information Center

Halpern, Robert

2013-01-01

Background: Over the past decade or so, the idea of joining early childhood education (ECE) and schooling has gained currency in the educational reform arena. Numerous education reform proposals and plans include ECE as a component. Scores of school districts around the country have added preschool classrooms to at least some of their elementary…

Teaming and Teaching in ECE: Neoliberal Reforms, Teacher Metaphors, and Identity in Head Start

ERIC Educational Resources Information Center

Bullough, Robert V., Jr.

2015-01-01

Noting that surprisingly little researcher attention has been directed toward teaming in early childhood education (ECE), the author conducted parallel case studies of two Head Start teacher teams in a single center. Drawing on interviews, extensive observational notes taken over the course of a school year, and teacher-generated metaphors, the…

Do Learning Stories Tell the Whole Story of Children's Learning? A Phenomenographic Enquiry

ERIC Educational Resources Information Center

Zhang, Qilong

2017-01-01

This study compares the stances of practitioners, parents and the quality assurance authority on the assessment of learning in New Zealand (NZ) early childhood education (ECE). The phenomenographic interview participants include practitioners (24) and parents (11) from 11 ECE settings. The reports issued by the Education Review Office (ERO) on all…

Impacts of Early Childhood Education on Medium- and Long-Term Educational Outcomes

ERIC Educational Resources Information Center

McCoy, Dana Charles; Yoshikawa, Hirokazu; Ziol-Guest, Kathleen M.; Duncan, Greg J.; Schindler, Holly S.; Magnuson, Katherine; Yang, Rui; Koepp, Andrew; Shonkoff, Jack P.

2017-01-01

Despite calls to expand early childhood education (ECE) in the United States, questions remain regarding its medium- and long-term impacts on educational outcomes. We use meta-analysis of 22 high-quality experimental and quasi-experimental studies conducted between 1960 and 2016 to find that on average, participation in ECE leads to statistically…

Early Childhood Teachers at the Center: A Qualitative Case Study of Professional Development in an Urban District

ERIC Educational Resources Information Center

Baker, Megina

2018-01-01

Professional development for early childhood educators (ECE PD) is an essential component of supporting a professional early childhood workforce. Yet research on ECE PD frequently centers on narrow fidelity data, while teachers' individual voices and teaching contexts are only rarely considered in order to understand teacher experiences with PD…

Moving up the Ladder: How Do States Deliver Quality Improvement Supports within Their Quality Rating and Improvement Systems? Brief

ERIC Educational Resources Information Center

Holod, Aleksandra; Faria, Ann-Marie; Weinberg, Emily; Howard, Eboni

2015-01-01

As national attention has increasingly focused on the potential for high-quality early childhood education (ECE) to improve children's school readiness, states have developed quality rating and improvement systems (QRISs) to document the quality of ECE programs, support systematic quality improvement, and provide clear information to families…

Choice of the Medium of Instruction in Kenyan Preschools: Averting Xenocentrism

ERIC Educational Resources Information Center

Waithaka, Esther N.

2017-01-01

This qualitative study sought to prompt a critical and reflective discourse on the dismal use of mother tongue in Kenyan early childhood education (ECE) institutions in an attempt to detect existence of xenocentrism. Although the Kenyan ECE policy framework sanctions use of the language of the catchment area when teaching and communicating with…

The World Bank's Position on Early Child Education in Brazil: A Critical Assessment of Contributions and Shortcomings

ERIC Educational Resources Information Center

Fernandes, Sabrina

2014-01-01

In 2010, the World Bank published a policy study on early child education (ECE) developments in Brazil, entitled "Early Child Education: Making Programs Work for Brazil's Most Important Generation. Development." This paper analyses the report's assessment of ECE policy in Brazil as well as the recommendations it provides. A critical…

Early Care and Education: Policy Considerations for Ensuring High-Quality Pre-K Programs

ERIC Educational Resources Information Center

Best, Jane; Cohen, Courtney

2013-01-01

Interest in early care and education (ECE), also referred to as an early childhood education, has escalated in recent years. The interest is bipartisan, as evidenced by the multiple ECE-related bills already introduced by the 113th Congress. Further, 39 states have implemented prekindergarten (pre-K) programs. In 2013, 27 governors mentioned ECE…

Chutes or Ladders? Creating Support Services to Help Early Childhood Students Succeed in Higher Education

ERIC Educational Resources Information Center

Dukakis, Kara; Bellm, Dan; Seer, Natalie; Lee, Yuna

2007-01-01

This report explores efforts in California to generally support nontraditional students, and early care and education (ECE) nontraditional students in particular. It is recommended that institutions of higher education and local planners work together to assess the needs of nontraditional students in their ECE programs, the adequacy of existing…

Early Care and Education as Educational Panacea: What Do We Really Know about Its Effectiveness?

ERIC Educational Resources Information Center

Lowenstein, Amy E.

2011-01-01

Most young children in the United States regularly spend time in early care and education (ECE) settings. Institutionalized messages surrounding ECE claim that it has the potential to promote children's life-long success, especially among low-income children. I examine the legitimacy of these claims by reviewing empirical evidence that bears on…

Early Childhood Educators' Perspectives and Practices about Inclusion of Children with Special Needs in Botswana

ERIC Educational Resources Information Center

Chhabra, Simmi; Bose, Kabita; Chadha, Neerja

2018-01-01

The purpose of this study was to investigate perspectives of Early Childhood Educators (ECEds) about inclusion of Children With Special Needs (CWSN) by examining their attitudes, training needs, and inclusive practices used in the inclusive classroom. One hundred twenty-eight ECEds completed a questionnaire that included the Scale of Teachers'…

The Current State of Early Childhood Education Programs: How Early Childhood Center Directors Manage Their Human Resources

ERIC Educational Resources Information Center

Arend, Lauren E.

2010-01-01

Purpose: Research in the field of early childhood education (ECE) demonstrated the association between skilled directors and high quality programs. Still, most state licensing requirements do not delineate the requisite knowledge or experience necessary to be an effective director. Many ECE directors advance to their position directly from the…

Four Good Reasons Why ECE Is Not Just Important, but Essential

ERIC Educational Resources Information Center

Mitchell, Anne W.

2009-01-01

As an advocate for young children and families and an advocate for early childhood education, the author has long argued for improving quality and for investing more public dollars in ECE. To make her case, the author used several different arguments, including: moral; workforce productivity; brain research; and return on investment. The author…

Overview of Integrated Child Development Services Programme in India: Some Policy Implications for Nepal.

ERIC Educational Resources Information Center

Shrestha, Kishor

This paper presents an overview of the Integrated Child Development Services (ICDS) program in India, discusses the context of Early Childhood Education (ECE) in Nepal, analyzes the best practices of the ICDS, and draws some policy implications for improving ECE in Nepal. The ICDS program is an integrated child development program with the…

Early Childhood Education in Pakistan--Progress and Challenges

ERIC Educational Resources Information Center

Shami, Pervez A.

2009-01-01

This paper is on Early Childhood Education (ECE)--a goal of Education For All (EFA), assesses the progress of Pakistan's efforts and strategies mainly during post Dakar period 2001-02 to 2005-06 and the major challenges being encountered. The information includes analysis of National Educational Data on ECE in the light of policies and plans, EFA…

Tensions between Discourses of Development, Religion, and Human Capital in Early Childhood Education Policy Texts: The Case of Indonesia

ERIC Educational Resources Information Center

Formen, Ali; Nuttall, Joce

2014-01-01

In this paper we consider how particular discourses have come to dominate early childhood education (ECE) policy in Indonesia. We briefly explain the governance of Indonesian ECE and then our approach to policy analysis using critical discourse analysis. Three prevalent discourses are identified and discussed: "developmentalism",…

The Impact of Every Classroom, Every Day on High School Student Achievement: Results from a School-Randomized Trial

ERIC Educational Resources Information Center

Early, Diane M.; Berg, Juliette K.; Alicea, Stacey; Si, Yajuan; Aber, J. Lawrence; Ryan, Richard M.; Deci, Edward L.

2016-01-01

Every Classroom, Every Day (ECED) is a set of instructional improvement interventions designed to increase student achievement in math and English/language arts (ELA). ECED includes three primary components: (a) systematic classroom observations by school leaders, (b) intensive professional development and support for math teachers and…

Funding Early Childhood Education: The President's Plan for the Future and States' Current Actions

ERIC Educational Resources Information Center

Best, Jane; Cohen, Courtney

2013-01-01

Increased attention to proposed federal early childhood education (ECE) legislation has sparked a debate on what the future holds for state-funded ECE systems. This brief explores how the goal of universal preschool is being shaped by the federal agenda and examines state programs in various stages of development. President Obama's Preschool for…

Improving Latino Children's Early Language and Literacy Development: Key Features of Early Childhood Education within Family Literacy Programmes

ERIC Educational Resources Information Center

Jung, Youngok; Zuniga, Stephen; Howes, Carollee; Jeon, Hyun-Joo; Parrish, Deborah; Quick, Heather; Manship, Karen; Hauser, Alison

2016-01-01

Noting the lack of research on how early childhood education (ECE) programmes within family literacy programmes influence Latino children's early language and literacy development, this study examined key features of ECE programmes, specifically teacher-child interactions and child engagement in language and literacy activities and how these…

A Novel Conceptual Model of Environmental Communal Education: Content Analysis Based on Distance Education Approach

ERIC Educational Resources Information Center

Hafezi, Soheila; Shobeiri, Seyed Mohammad; Sarmadi, Mohammad Reza; Ebadi, Abbas

2013-01-01

Environmental education as a learning process increases people's knowledge and awareness about the environment. Although in some countries, the Environmental Communal Education (ECE) is the core of the environmental education by formal and informal organizations and groups, but, it has not clarified the meaning of the ECE's concept. Therefore the…

ECE-imaging of the H-mode pedestal (invited).

PubMed

Tobias, B J; Austin, M E; Boom, J E; Burrell, K H; Classen, I G J; Domier, C W; Luhmann, N C; Nazikian, R; Snyder, P B

2012-10-01

A synthetic diagnostic has been developed that reproduces the highly structured electron cyclotron emission (ECE) spectrum radiated from the edge region of H-mode discharges. The modeled dependence on local perturbations of the equilibrium plasma pressure allows for interpretation of ECE data for diagnosis of local quantities. Forward modeling of the diagnostic response in this region allows for improved mapping of the observed fluctuations to flux surfaces within the plasma, allowing for the poloidal mode number of coherent structures to be resolved. In addition, other spectral features that are dependent on both T(e) and n(e) contain information about pedestal structure and the electron energy distribution of localized phenomena, such as edge filaments arising during edge-localized mode (ELM) activity.

2012-2013 Delaware Valley Household Travel Survey | Transportation Secure

Science.gov Websites

Data Center | NREL 12-2013 Delaware Valley Household Travel Survey 2012-2013 Delaware Valley Household Travel Survey The 2012-2013 Delaware Valley Household Travel Survey collected data for multiple ) sponsored the survey in collaboration with AbtSRBI. Methodology A sampling strategy was designed to recruit

Trends in Delaware's Forests

Treesearch

Northeastern Research Station

2002-01-01

Forests protect watersheds, provide opportunities for recreation and settings for aesthetic enjoyment, serve as habitat for wildlife, and produce wood and other forest products. The forests of Delaware contribute greatly to the quality of life of the residents, making the State a better place in which to live. This brochure highlights significant trends in Delaware?s...

75 FR 9426 - Delaware River and Bay Oil Spill Advisory Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2008-0333] Delaware River and Bay Oil... Delaware River and Bay Oil Spill Advisory Committee (DRBOSAC) will meet in Philadelphia, PA to discuss various issues to improve oil spill prevention and response strategies for the Delaware River and Bay...

Race to the Top - Early Learning Challenge: 2014 Annual Performance Report. Delaware

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2015

2015-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2014 describes Delaware's accomplishments, lessons learned, challenges, and strategies Delaware will implement to address those challenges. At the end of Year Three of the Early Learning Challenge Grant, Delaware continues to make significant progress…

78 FR 39601 - Safety Zone, Sugar House Casino Fireworks Display, Delaware River; Philadelphia, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

...-AA00 Safety Zone, Sugar House Casino Fireworks Display, Delaware River; Philadelphia, PA AGENCY: Coast... the Delaware River. Sugar House Casino has contracted with Pyrotecnico Fireworks to arrange for this display. The Captain of the Port, Sector Delaware Bay, has determined that the Sugar House Casino...

Delaware County Community College Business and International Education Program.

ERIC Educational Resources Information Center

Delaware County Community Coll., Media, PA.

In 1987, Delaware County Community College (DCCC) initiated the Delaware Valley Trade Enhancement Project, comprising a number of activities to promote the involvement of local firms in international trade. One of the first activities of the Delaware Valley Trade Enhancement project was a survey of over 6,000 small and medium-sized businesses in…

78 FR 68026 - Foreign-Trade Zone (FTZ) 99-Wilmington, Delaware, Notification of Proposed Production Activity...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-13

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-94-2013] Foreign-Trade Zone (FTZ) 99--Wilmington, Delaware, Notification of Proposed Production Activity, Noramco, Inc., (Pharmaceutical Intermediate), Wilmington, Delaware The Delaware Economic Development Office, grantee of FTZ 99, submitted a notification of proposed production activity to...

Quantification and probabilistic modeling of CRT obsolescence for the State of Delaware

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schumacher, Kelsea A., E-mail: kschum@udel.edu; Schumacher, Thomas, E-mail: schumact@udel.edu; Agbemabiese, Lawrence, E-mail: agbe@udel.edu

2014-11-15

Highlights: • We modeled the obsolescence of cathode ray tube devices in the State of Delaware. • 411,654 CRT units or ∼16,500 metric tons have been recycled in Delaware since 2002. • The peak of the CRT obsolescence in Delaware passed by 2012. • The Delaware average CRT recycling rate between 2002 and 13 was approximately 27.5%. • CRTs will continue to infiltrate the system likely until 2033. - Abstract: The cessation of production and replacement of cathode ray tube (CRT) displays with flat screen displays have resulted in the proliferation of CRTs in the electronic waste (e-waste) recycle stream.more » However, due to the nature of the technology and presence of hazardous components such as lead, CRTs are the most challenging of electronic components to recycle. In the State of Delaware it is due to this challenge and the resulting expense combined with the large quantities of CRTs in the recycle stream that electronic recyclers now charge to accept Delaware’s e-waste. Therefore it is imperative that the Delaware Solid Waste Authority (DSWA) understand future quantities of CRTs entering the waste stream. This study presents the results of an assessment of CRT obsolescence in the State of Delaware. A prediction model was created utilizing publicized sales data, a variety of lifespan data as well as historic Delaware CRT collection rates. Both a deterministic and a probabilistic approach using Monte Carlo Simulation (MCS) were performed to forecast rates of CRT obsolescence to be anticipated in the State of Delaware. Results indicate that the peak of CRT obsolescence in Delaware has already passed, although CRTs are anticipated to enter the waste stream likely until 2033.« less

The Courts, the Legislature, and Delaware's Resegregation: A Report on School Segregation in Delaware, 1989-­2010

ERIC Educational Resources Information Center

Niemeyer, Arielle

2014-01-01

Delaware's history with school desegregation is complicated and contradictory. The state both advanced and impeded the goals of "Brown v. Board of Education." After implementing desegregation plans that were ineffective by design, Delaware was ultimately placed under the first metropolitan, multi-district desegregation court order in the…

Revising the Experiential Learning Component of the Business Capstone Course at Delaware Technical Community College's George Campus

ERIC Educational Resources Information Center

Roux, June N.

2017-01-01

This Executive Position Paper examines the experiential learning component of the business capstone course at Delaware Technical Community College's George campus in Wilmington, Delaware. As a statewide institution of higher education, Delaware Tech offers associate of applied science degrees in practical, skills-based majors, including a number…

Taking Stock: An Analysis of Delaware's High School Standards and Course Requirements

ERIC Educational Resources Information Center

Achieve, Inc., 2005

2005-01-01

Delaware's secretary of education and the president of the State Board of Education asked Achieve to provide an analysis of the quality of Delaware's high school content standards and its course-taking requirements. In assisting Delaware in its commitment to raising the quality of its expectations for high school graduates, Achieve examined the…

Sensitivity of UK butterflies to local climatic extremes: which life stages are most at risk?

PubMed

McDermott Long, Osgur; Warren, Rachel; Price, Jeff; Brereton, Tom M; Botham, Marc S; Franco, Aldina M A

2017-01-01

There is growing recognition as to the importance of extreme climatic events (ECEs) in determining changes in species populations. In fact, it is often the extent of climate variability that determines a population's ability to persist at a given site. This study examined the impact of ECEs on the resident UK butterfly species (n = 41) over a 37-year period. The study investigated the sensitivity of butterflies to four extremes (drought, extreme precipitation, extreme heat and extreme cold), identified at the site level, across each species' life stages. Variations in the vulnerability of butterflies at the site level were also compared based on three life-history traits (voltinism, habitat requirement and range). This is the first study to examine the effects of ECEs at the site level across all life stages of a butterfly, identifying sensitive life stages and unravelling the role life-history traits play in species sensitivity to ECEs. Butterfly population changes were found to be primarily driven by temperature extremes. Extreme heat was detrimental during overwintering periods and beneficial during adult periods and extreme cold had opposite impacts on both of these life stages. Previously undocumented detrimental effects were identified for extreme precipitation during the pupal life stage for univoltine species. Generalists were found to have significantly more negative associations with ECEs than specialists. With future projections of warmer, wetter winters and more severe weather events, UK butterflies could come under severe pressure given the findings of this study. © 2016 The Authors. Journal of Animal Ecology © 2016 British Ecological Society.

Energy efficiency and its relationship with milk, body, and intake traits and energy status among primiparous Nordic Red dairy cattle.

PubMed

Mäntysaari, P; Liinamo, A-E; Mäntysaari, E A

2012-06-01

Existing variation in energy efficiency and its relationship with milk yield and milk composition, body weight and body condition, feed intake, and energy status was studied in primiparous Nordic Red dairy cattle with data including 3,752 weekly records from 145 cows. Energy efficiency was defined as energy conversion efficiency (ECE) and as residual energy intake (REI) estimated based on Finnish feeding standards (REI₁) or from the current data (REI₂). The results indicated true phenotypic variation in energy efficiency of the cows. The proportion of total variance due to the animal was 0.35 for REI₁, 0.30 for REI₂, and 0.50 for ECE. The high efficiency based on ECE was associated with increased mobilization of body reserves (r = -0.50) and decreased dry matter intake (r = -0.51). With REI as an energy efficiency measure, the increased efficiency was associated with a large decrease in feed intake (REI₁: r = 0.60; REI2: r = 0.74) without any effect on body weight change (REI₁: r = 0.13; REI2: r = 0.00). Increased efficiency based on ECE and REI₁ was associated with increased milk yield (ECE: r = 0.58; REI₁: r = -0.41). A clear effect of stage of lactation on REI was found, which could be caused by true differences in utilization of metabolizable energy during lactation. However, it might also be related, in part, to the lack of knowledge of the composition of body weight change in the beginning of lactation. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Investigating Business Schools' Intentions about Offering E-Commerce Education Using an Extended Theory of Planned Behavior

ERIC Educational Resources Information Center

Dodor, Jean Baptiste K.; Rana, Dharam S.

2009-01-01

This study investigates business schools' intentions about offering e-commerce education (ECE) using an extended theory of planned behavior (ETPB). The need for an adequate match between future supply and demand of e-commerce skills constitutes the main motivation for the study. The results show that most business schools consider ECE important…

Korean Early Childhood Educators' Multi-Dimensional Teacher Self-Efficacy and ECE Center Climate and Depression Severity in Teachers as Contributing Factors

ERIC Educational Resources Information Center

Kim, Yeon Ha; Kim, Yang Eun

2010-01-01

This study investigated profiles of South Korean early childhood educators' teacher self-efficacy and contributing factors to teacher self-efficacy. The contributing factors were examined with a focus on early childhood education (ECE) center climate and depression severity in teachers as well as teacher and classroom characteristics. The results…

Learning Together: A Study of Six B.A. Completion Cohort Programs in Early Care and Education--Year 4

ERIC Educational Resources Information Center

Kipnis, F.; Whitebook, M.; Almaraz, M.; Sakai, L.; Austin, L. J. E.

2012-01-01

The Learning Together longitudinal study focuses on four counties' efforts to expand bachelor's degree opportunities in early care and education (ECE) for adults currently working in the field. The "student cohort" model--in which small groups of ECE students with similar interests and characteristics pursue a bachelor's degree together,…

Shifting Views: Exploring the Potential for Technology Integration in Early Childhood Education Programs

ERIC Educational Resources Information Center

Dietze, Beverlie; Kashin, Diane

2013-01-01

Using technology with children in play-based early learning programs creates questions for some within the Early Childhood Education (ECE) community. This paper presents how two faculty who teach in ECE-related degree programs integrated educational technology into their teaching pedagogy as a way to model to their students how it can be used to…

Getting on the Same Page: Identifying Goals for Technology Use in Early Childhood Education. Policy Brief

ERIC Educational Resources Information Center

Daugherty, Lindsay; Dossani, Rafiq; Johnson, Erin-Elizabeth; Wright, Cameron

2014-01-01

Technology use among young children is increasingly a fact of life, and establishing a clear set of goals that are broadly accepted by stakeholders is critical to planning for the successful integration of technology into early childhood education (ECE). However, debates about the role of technology in ECE settings are ongoing, with some…

An Exploratory Study of Young Students' Core Virtues of e-Character Education: The Taiwanese Teachers' Perspective

ERIC Educational Resources Information Center

Chang, Chih-Ming; Chou, Chien

2015-01-01

The e-character education (e-CE) approach refers to systems of ethics education that pertain specifically to cyberspace. This exploratory study used a survey to collect 2495 teachers' responses regarding virtues important to e-CE. Furthermore, in order to identify the teaching concerns associated with these most important virtues, this study used…

Development and Evaluation of an Integrated Pest Management Toolkit for Child Care Providers

ERIC Educational Resources Information Center

Alkon, Abbey; Kalmar, Evie; Leonard, Victoria; Flint, Mary Louise; Kuo, Devina; Davidson, Nita; Bradman, Asa

2012-01-01

Young children and early care and education (ECE) staff are exposed to pesticides used to manage pests in ECE facilities in the United States and elsewhere. The objective of this pilot study was to encourage child care programs to reduce pesticide use and child exposures by developing and evaluating an Integrated Pest Management (IPM) Toolkit for…

A Comprehensive Review of the Status of Early Childhood Development in the Middle East and North Africa.

ERIC Educational Resources Information Center

Khattab, Mohammad Salih

This report reviews the status of early childhood education (ECE) programs in UNICEF's Middle East and North Africa region. The report compiles information about ECE programs in 18 countries based on a questionnaire sent to UNICEF country offices and other sources. The introduction sets out the economic and social rationales for investing in early…

Pre-Kindergarten and Kindergarten Classroom Quality and Children's Social and Academic Skills in Early Elementary Grades

ERIC Educational Resources Information Center

Mokrova, Irina; Broekhuizen, Martine; Burchinal, Margaret

2015-01-01

A growing body of research has shown that high quality early care and education (ECE) is positively related to the development of children's social and academic skills (e.g., Barnett, 2011; Lamb & Ahnert, 2006; NICHD ECCRN, 2006). There is evidence that high quality ECE experiences can improve children's levels of social adjustment (Bierman et…

How Much and What Kind? Identifying an Adequate Technology Infrastructure for Early Childhood Education. Policy Brief

ERIC Educational Resources Information Center

Daugherty, Lindsay; Dossani, Rafiq; Johnson, Erin-Elizabeth; Wright, Cameron

2014-01-01

To realize the potential benefits of technology use in early childhood education (ECE), and to ensure that technology can help to address the digital divide, providers, families of young children, and young children themselves must have access to an adequate technology infrastructure. The goals for technology use in ECE that a technology…

Building Community Systems for Young Children: Early Childhood Education. Building State Early Childhood Comprehensive Systems Series, Number 11

ERIC Educational Resources Information Center

Bassok, Daphna; Stipek, Deborah; Inkelas, Moira; Kuo, Alice

2005-01-01

This report examines the importance and funding sources of early child care and education (ECE), and the ways in which the State Early Childhood Comprehensive Systems (SECCS) Initiative improves early childhood outcomes. Section I presents what is known about the importance of ECE, quality and access. Section II describes the current funding…

ITER ECE Diagnostic: Design Progress of IN-DA and the diagnostic role for Physics

NASA Astrophysics Data System (ADS)

Pandya, H. K. B.; Kumar, Ravinder; Danani, S.; Shrishail, P.; Thomas, Sajal; Kumar, Vinay; Taylor, G.; Khodak, A.; Rowan, W. L.; Houshmandyar, S.; Udintsev, V. S.; Casal, N.; Walsh, M. J.

2017-04-01

The ECE Diagnostic system in ITER will be used for measuring the electron temperature profile evolution, electron temperature fluctuations, the runaway electron spectrum, and the radiated power in the electron cyclotron frequency range (70-1000 GHz), These measurements will be used for advanced real time plasma control (e.g. steering the electron cyclotron heating beams), and physics studies. The scope of the Indian Domestic Agency (IN-DA) is to design and develop the polarizer splitter units; the broadband (70 to 1000 GHz) transmission lines; a high temperature calibration source in the Diagnostics Hall; two Michelson Interferometers (70 to 1000 GHz) and a 122-230 GHz radiometer. The remainder of the ITER ECE diagnostic system is the responsibility of the US domestic agency and the ITER Organization (IO). The design needs to conform to the ITER Organization’s strict requirements for reliability, availability, maintainability and inspect-ability. Progress in the design and development of various subsystems and components considering various engineering challenges and solutions will be discussed in this paper. This paper will also highlight how various ECE measurements can enhance understanding of plasma physics in ITER.

Material System Engineering for Advanced Electrocaloric Cooling Technology

NASA Astrophysics Data System (ADS)

Qian, Xiaoshi

Electrocaloric effect refers to the entropy change and/or temperature change in dielectrics caused by the electric field induced polarization change. Recent discovery of giant ECE provides an opportunity to realize highly efficient cooling devices for a broad range of applications ranging from household appliances to industrial applications, from large-scale building thermal management to micro-scale cooling devices. The advances of electrocaloric (EC) based cooling device prototypes suggest that highly efficient cooling devices with compact size are achievable, which could lead to revolution in next generation refrigeration technology. This dissertation focuses on both EC based materials and cooling devices with their recent advances that address practical issues. Based on better understandings in designing an EC device, several EC material systems are studied and improved to promote the performances of EC based cooling devices. In principle, applying an electric field to a dielectric would cause change of dipolar ordering states and thus a change of dipolar entropy. Giant ECE observed in ferroelectrics near ferroelectric-paraelectric (FE-PE) transition temperature is owing to the large dipolar orientation change, between random-oriented dipolar states in paraelectric phase and spontaneous-ordered dipolar states in ferroelectric phases, which is induced by external electric fields. Besides pursuing large ECE, studies on EC cooling devices indicated that EC materials are required to possess wide operational temperature window, in which large ECE can be maintained for efficient operations. Although giant ECE was first predicted in ferroelectric polymers, where the large effect exhibits near FEPE phase transition, the narrow operation temperature window poses obstacles for these normal ferroelectrics to be conveniently perform in wide range of applications. In this dissertation, we demonstrated that the normal ferroelectric polymers can be converted to relaxor ferroelectric polymers which possess both giant ECE (27 Kelvin temperature drop) and much wider operating temperature window (over 50 kelvin covering RT) by proper defect modification which delicately tailors ferroelectrics in meso-, micro- and molecular scales. In addition, in order to be practical, EC device requires EC material can be driven at low electric fields upon achieve the large ECE. It is demonstrated in this dissertation that by facially modifying materials structure in meso-, micro- and molecular scale, lowfield ECE can be greatly improved. Large ECE, induced by low electric fields and existing in wide temperature window, is a major improvement in EC materials for practical applications. Besides EC polymers, this thesis also investigated EC ceramics. Due to several unique opportunities offered by the EC ceramics, Ba(ZrxTi 1-x)O3 (BZT), that is studied. (i) This class of EC ceramics offers a possibility to explore the invariant critical point (ICP), which maximizes the number of coexistent phase and provides a nearly vanishing energy barrier for switching among different phases. As demonstrated in this thesis, the BZT bulk ceramics at x˜ 0.2 exhibits a large adiabatic temperature drop DeltaTc=4.5 K, a large isothermal entropy change DeltaS = 8 Jkg-1K-1, a large EC coefficient (|DeltaT c/DeltaE| = 0.52x10-6 KmV-1 and DeltaS/DeltaE=0.93x10 -6 Jmkg-1K-1V-1) over a wide operating temperature range Tspan>30K. (ii) The thermal conductivity of EC ceramics is in general, much higher than that of EC polymers, and consequently they will allow EC cooling configurations which are not accessible by the EC polymers. Moreover, in the same device configuration, the high thermal conductivity of EC ceramics (kappa> 5 W/mK, compared with EC polymer, ˜ 0.25 W/mK) allows higher operation frequency and therefore a higher cooling power. (iii) Well-established fabrication processes of multilayer ceramic capacitor (MLCC) provide a foundation for the EC ceramic toward mass production. In this thesis, BZT thick film double layers have been fabricated and large ECE has been directly measured. EC induced temperature drop (DeltaT) around 6.3 °C and entropy change (DeltaS) of 11.0 Jkg-1K -1 are observed under an electric field of DeltaE=14.6 MV/m at 40 °C was observed in BZT thick film double layers. The result encourages further investigations on ECE in MLCC for practical applications. (Abstract shortened by ProQuest.).

Genetic vulnerability interacts with parenting and early care education to predict increasing externalizing behavior.

PubMed

Lipscomb, Shannon T; Laurent, Heidemarie; Neiderhiser, Jenae M; Shaw, Daniel S; Natsuaki, Misaki N; Reiss, David; Leve, Leslie D

2014-01-01

The current study examined interactions among genetic influences and children's early environments on the development of externalizing behaviors from 18 months to 6 years of age. Participants included 233 families linked through adoption (birth parents and adoptive families). Genetic influences were assessed by birth parent temperamental regulation. Early environments included both family (overreactive parenting) and out-of-home factors (center-based Early Care and Education; ECE). Overreactive parenting predicted more child externalizing behaviors. Attending center-based ECE was associated with increasing externalizing behaviors only for children with genetic liability for dysregulation. Additionally, children who were at risk for externalizing behaviors due to both genetic variability and exposure to center-based ECE were more sensitive to the effects of overreactive parenting on externalizing behavior than other children.

Genetic vulnerability interacts with parenting and early care education to predict increasing externalizing behavior

PubMed Central

Lipscomb, Shannon T.; Laurent, Heidemarie; Neiderhiser, Jenae M.; Shaw, Daniel S.; Natsuaki, Misaki N.; Reiss, David; Leve, Leslie D.

2014-01-01

The current study examined interactions among genetic influences and children’s early environments on the development of externalizing behaviors from 18 months to 6 years of age. Participants included 233 families linked through adoption (birth parents and adoptive families). Genetic influences were assessed by birth parent temperamental regulation. Early environments included both family (overreactive parenting) and out-of-home factors (center-based Early Care and Education; ECE). Overreactive parenting predicted more child externalizing behaviors. Attending center-based ECE was associated with increasing externalizing behaviors only for children with genetic liability for dysregulation. Additionally, children who were at risk for externalizing behaviors due to both genetic variability and exposure to center-based ECE were more sensitive to the effects of overreactive parenting on externalizing behavior than other children. PMID:25067867

Digital Mapping of Soil Salinity and Crop Yield across a Coastal Agricultural Landscape Using Repeated Electromagnetic Induction (EMI) Surveys

PubMed Central

Yao, Rongjiang; Yang, Jingsong; Wu, Danhua; Xie, Wenping; Gao, Peng; Jin, Wenhui

2016-01-01

Reliable and real-time information on soil and crop properties is important for the development of management practices in accordance with the requirements of a specific soil and crop within individual field units. This is particularly the case in salt-affected agricultural landscape where managing the spatial variability of soil salinity is essential to minimize salinization and maximize crop output. The primary objectives were to use linear mixed-effects model for soil salinity and crop yield calibration with horizontal and vertical electromagnetic induction (EMI) measurements as ancillary data, to characterize the spatial distribution of soil salinity and crop yield and to verify the accuracy of spatial estimation. Horizontal and vertical EMI (type EM38) measurements at 252 locations were made during each survey, and root zone soil samples and crop samples at 64 sampling sites were collected. This work was periodically conducted on eight dates from June 2012 to May 2013 in a coastal salt-affected mud farmland. Multiple linear regression (MLR) and restricted maximum likelihood (REML) were applied to calibrate root zone soil salinity (ECe) and crop annual output (CAO) using ancillary data, and spatial distribution of soil ECe and CAO was generated using digital soil mapping (DSM) and the precision of spatial estimation was examined using the collected meteorological and groundwater data. Results indicated that a reduced model with EMh as a predictor was satisfactory for root zone ECe calibration, whereas a full model with both EMh and EMv as predictors met the requirement of CAO calibration. The obtained distribution maps of ECe showed consistency with those of EMI measurements at the corresponding time, and the spatial distribution of CAO generated from ancillary data showed agreement with that derived from raw crop data. Statistics of jackknifing procedure confirmed that the spatial estimation of ECe and CAO exhibited reliability and high accuracy. A general increasing trend of ECe was observed and moderately saline and very saline soils were predominant during the survey period. The temporal dynamics of root zone ECe coincided with those of daily rainfall, water table and groundwater data. Long-range EMI surveys and data collection are needed to capture the spatial and temporal variability of soil and crop parameters. Such results allowed us to conclude that, cost-effective and efficient EMI surveys, as one part of multi-source data for DSM, could be successfully used to characterize the spatial variability of soil salinity, to monitor the spatial and temporal dynamics of soil salinity, and to spatially estimate potential crop yield. PMID:27203697

Digital Mapping of Soil Salinity and Crop Yield across a Coastal Agricultural Landscape Using Repeated Electromagnetic Induction (EMI) Surveys.

PubMed

Yao, Rongjiang; Yang, Jingsong; Wu, Danhua; Xie, Wenping; Gao, Peng; Jin, Wenhui

2016-01-01

Reliable and real-time information on soil and crop properties is important for the development of management practices in accordance with the requirements of a specific soil and crop within individual field units. This is particularly the case in salt-affected agricultural landscape where managing the spatial variability of soil salinity is essential to minimize salinization and maximize crop output. The primary objectives were to use linear mixed-effects model for soil salinity and crop yield calibration with horizontal and vertical electromagnetic induction (EMI) measurements as ancillary data, to characterize the spatial distribution of soil salinity and crop yield and to verify the accuracy of spatial estimation. Horizontal and vertical EMI (type EM38) measurements at 252 locations were made during each survey, and root zone soil samples and crop samples at 64 sampling sites were collected. This work was periodically conducted on eight dates from June 2012 to May 2013 in a coastal salt-affected mud farmland. Multiple linear regression (MLR) and restricted maximum likelihood (REML) were applied to calibrate root zone soil salinity (ECe) and crop annual output (CAO) using ancillary data, and spatial distribution of soil ECe and CAO was generated using digital soil mapping (DSM) and the precision of spatial estimation was examined using the collected meteorological and groundwater data. Results indicated that a reduced model with EMh as a predictor was satisfactory for root zone ECe calibration, whereas a full model with both EMh and EMv as predictors met the requirement of CAO calibration. The obtained distribution maps of ECe showed consistency with those of EMI measurements at the corresponding time, and the spatial distribution of CAO generated from ancillary data showed agreement with that derived from raw crop data. Statistics of jackknifing procedure confirmed that the spatial estimation of ECe and CAO exhibited reliability and high accuracy. A general increasing trend of ECe was observed and moderately saline and very saline soils were predominant during the survey period. The temporal dynamics of root zone ECe coincided with those of daily rainfall, water table and groundwater data. Long-range EMI surveys and data collection are needed to capture the spatial and temporal variability of soil and crop parameters. Such results allowed us to conclude that, cost-effective and efficient EMI surveys, as one part of multi-source data for DSM, could be successfully used to characterize the spatial variability of soil salinity, to monitor the spatial and temporal dynamics of soil salinity, and to spatially estimate potential crop yield.

18. Photocopy of print (Original in Smith's History of Delaware ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Photocopy of print (Original in Smith's History of Delaware County, Pennsylvania) MAIN AND EAST ELEVATIONS - Caleb Pusey House, 15 Race Street (Landingford Plantation), Upland, Delaware County, PA

Creating an Early Warning System: Predictors of Dropout in Delaware. REL Mid-Atlantic Technical Assistance Brief. REL MA 1.2.75-10

ERIC Educational Resources Information Center

Uekawa, Kazuaki; Merola, Stacey; Fernandez, Felix; Porowski, Allan

2010-01-01

This Technical Brief presents an historical analysis of key indicators of dropout for Delaware students in grades 9-12. Cut points for key risk indicators of high school dropout for the State of Delaware are provided. Using data provided by the Delaware Department of Education (DDOE), relationships between student dropout and several student…

Hydrodynamics and inundation of a tidal saltmarsh in Kent County, Delaware

NASA Astrophysics Data System (ADS)

Pieterse, A.; Puleo, J. A.; McKenna, T. E.

2013-12-01

A 2-week field experiment was conducted in March and April 2013 in a tidal wetland in Kent County, Delaware. The study area was a tidal flat fed by a secondary channel of a small tributary of Delaware Bay. The goal of the field study was to investigate spatio-temporal variability in the hydrodynamics of the saltmarsh and tidal flat, over the period of one spring-neap tidal cycle. The experiment combined remotely-sensed imagery with high-frequency in-situ measurements. A tower with imagers (RGB, NIR, TIR) was deployed to quantify the spatial variations of inundation of the channels, flat and marsh. In-situ sensors that measured flow velocity, sediment concentration and water depth were deployed on the tidal flat and in the channels. At three locations, a Nortek Vectrino II - profiling velocimeter was deployed that measured a 30 mm velocity profile at 1 mm vertical increments at 100 Hz. These velocity profiles are used to compute turbulent kinetic energy, energy dissipation and stress profiles close to the bed. Preliminary results of the experiment show that peak velocities occur at the beginning of the rising and end of ebbing tide, when the water levels are low. At these instances, peaks in turbulence and bed stress also occur, which coincides with the largest sediment concentrations that were observed. During both rising and falling tide, flow velocities up to 0.4 m/s were observed in the main channel leading to the tidal flat. After these initial large flow velocities, the flat inundated very quickly, and flow velocities decreased. Furthermore, due to the large flow velocities, bed erosion often took place in the channel at the beginning of each high tide, while deposition occurred during ebbing tide, resulting in small net changes over the tidal cycle. The velocities in the channel relative to those on the adjacent flat were investigated. Furthermore, the relationship between near-bed turbulence and suspended sediment concentration and an analysis of the near-bed turbulence budget will be discussed.

An epidemiologic and entomologic investigation of a cluster of Rocky Mountain spotted fever cases in Delaware.

PubMed

Rotz, L; Callejas, L; McKechnie, D; Wolfe, D; Gaw, E; Hathcock, L; Childs, J

1998-06-01

Rocky Mountain spotted fever (RMSF) continues to be the most common fatal tick-borne illness in the United States. In August of 1996, four children attending a summer camp in Delaware were diagnosed with RMSF. This report summarizes the results of the epidemiologic and entomologic investigation conducted by the Delaware Division of Public Health and the Centers for Disease Control and Prevention regarding this cluster of RMSF cases. Epidemiologic and clinical aspects of RMSF, as well as previously reported clusters of the disease, are also reviewed. A questionnaire regarding symptoms and activities was administered via telephone to 163 (73 percent) of the 223 attendees. A suspected case was defined as an illness in a person attending the camp between August 11 and 17 that occurred during the two-week period following the session, characterized by either 1) fever with one or more symptoms (i.e., headache, rash, myalgia, or fatigue) or 2) no fever with two or more symptoms. Cases of RMSF were confirmed by serologic evaluation. Seven of 13 patients with suspected RMSF submitted sera for testing. Four patients had confirmed RMSF; three were males, and the median age was 12.5 years compared with 12 years for all attendees. All confirmed patients reported fever, headache, fatigue, and rash. An increased risk of becoming ill was associated with overnight camping at site A (Odds Ratio (OR) undefined, p = 0.02), visiting or overnight camping at site B (OR undefined, p = 0.003 and 0.002), and leaving the trails when hiking (OR undefined, p = 0.02). These data suggest that development of RMSF was associated with visiting or camping at specific sites and behavior likely to increase contact with ticks. Camp supervisors were advised to educate campers regarding tick bite prevention measures, reduce underbrush around campsites, and encourage campers to remain on the trails. Health care providers should remain aware of the increased risk for RMSF during the spring, summer, and fall months.

Reframing the Debate about the Relationship between Learning and Development: An Effort to Resolve Dilemmas and Reestablish Dialogue in a Fractured Field

ERIC Educational Resources Information Center

Fowler, R. Clarke

2017-01-01

The field of early childhood education (ECE) is currently unable to reach consensus on the extent to which ECE should be based on child development. One manifestation of this situation is the dilemma that early educators purportedly face between teaching the whole child and the curriculum, between developmentally appropriate practice (DAP) and…

Preparing Teachers of Young Children: The Current State of Knowledge, and a Blueprint for the Future. Executive Summary. Policy Report

ERIC Educational Resources Information Center

Whitebook, Marcy; Gomby, Deanna; Bellm, Dan; Sakai, Laura; Kipnis, Fran

2009-01-01

Across the political spectrum, high-quality early care and education (ECE) is viewed as essential to educational reform. No ECE program can succeed without teachers who can establish warm and caring relationships with children, light the fires of children's curiosity and love of learning, and foster their development and readiness for school.…

The Effect of Expertise-Based Training on the Quality of Digital Stories Created to Teach Mathematics to Young Children

ERIC Educational Resources Information Center

Sancar-Tokmak, Hatice; Incikabi, Lutfi

2013-01-01

This study investigated the effect of expertise-based training (XBT) on the quality of digital stories created by early childhood education (ECE) pre-service teachers. The participants of the study were 69 pre-service teachers from the ECE Department. The study was experimental, utilizing a static-group pre-test/post-test design, supported with…

Bodies Displayed on Walls: Are Children's Bodies Represented in an Inclusive Way in the Pictures on the Walls in Their Early Childhood Educational Environments?

ERIC Educational Resources Information Center

Martínez-Bello, Vladimir E.; Martínez-Bello, Judith T.

2017-01-01

The messages conveyed by visual representations in the early childhood education (ECE) environment are critical to ensuring the success of inclusive practices. Given that anti-bias education permeates and affects everything which takes place in ECE institutions, the challenge for early childhood educators is to think creatively about how classroom…

The Tension between Teacher Control and Children's Freedom in a Child-Centered Classroom: Resolving the Practical Dilemma through a Closer Look at the Related Theories

ERIC Educational Resources Information Center

Tzuo, Pei Wen

2007-01-01

This article explores the meaning of child-centeredness in Early Childhood Education (ECE), by shedding light on the nuanced tensions between teacher control and children's freedom. While ECE professionals advocate the importance of children's individual interests and needs in education, they diverge somewhat in their perspectives about the…

A One-Credit Hands-On Introductory Course in Electrical and Computer Engineering Using a Variety of Topic Modules

ERIC Educational Resources Information Center

Pierre, J. W.; Tuffner, F. K.; Anderson, J. R.; Whitman, D. L.; Ula, A. H. M. S.; Kubichek, R. F.; Wright, C. H. G.; Barrett, S. F.; Cupal, J. J.; Hamann, J. C.

2009-01-01

This paper describes a one-credit laboratory course for freshmen majoring in electrical and computer engineering (ECE). The course is motivational in nature and exposes the students to a wide range of areas of electrical and computer engineering. The authors believe it is important to give freshmen a broad perspective of what ECE is all about, and…

Respecting but Not Sustaining Play: Early Childhood Educators' and Home Childcare Providers' Practices That Support Children's Play

ERIC Educational Resources Information Center

Lemay, Lise; Bigras, Nathalie; Bouchard, Caroline

2016-01-01

This study examined and compared the extent to which early childhood educators' (ECEs) and home childcare providers' (HCPs) practices supported children's play. The sample included 50 ECEs and 20 HCPs in settings that care for 70 children at 18, 24, and 36 months old. At each time point, the childcare process quality was observed using the…

Contrasting Effects of Extreme Drought and Snowmelt Patterns on Mountain Plants along an Elevation Gradient.

PubMed

Rosbakh, Sergey; Leingärtner, Annette; Hoiss, Bernhard; Krauss, Jochen; Steffan-Dewenter, Ingolf; Poschlod, Peter

2017-01-01

Despite the evidence that increased frequency and magnitude of extreme climate events (ECE) considerably affect plant performance, there is still a lack of knowledge about how these events affect mountain plant biodiversity and mountain ecosystem functioning. Here, we assessed the short-term (one vegetation period) effects of simulated ECEs [extreme drought (DR), advanced and delayed snowmelt (AD and DE), respectively] on the performance of 42 plant species occurring in the Bavarian Alps (Germany) along an elevational gradient of 600-2000 m a.s.l. in terms of vegetative growth and reproduction performance. We demonstrate that plant vegetative and generative traits respond differently to the simulated ECEs, but the nature and magnitude treatment effects strongly depend on study site location along the elevational gradient, species' altitudinal origin and plant functional type (PFT) of the target species. For example, the negative effect of DR treatment on growth (e.g., lower growth rates and lower leaf nitrogen content) and reproduction (e.g., lower seed mass) was much stronger in upland sites, as compared to lowlands. Species' response to the treatments also differed according to their altitudinal origin. Specifically, upland species responded negatively to extreme DR (e.g., lower growth rates and lower leaf carbon concentrations, smaller seed set), whereas performance of lowland species remained unaffected (e.g., stable seed set and seed size) or even positively responded (e.g., higher growth rates) to that treatment. Furthermore, we were able to detect some consistent differences in responses to the ECEs among three PFTs (forbs, graminoids, and legumes). For instance, vegetative growth and sexual reproduction of highly adaptable opportunistic graminoids positively responded to nearly all ECEs, likely on the costs of other, more conservative, forbs and legumes. Our results suggest that ECEs can significantly modify the performance of specific plant groups and therefore lead to changes in plant community structure and composition under ongoing climate change. Our study therefore underlines the need for more experimental studies on the effects of extreme climate events to understand the potential consequences of climate change for the alpine ecosystem.

5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.58. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.73 - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

Energy Efficiency Team Helping Delaware Towns Find Savings

EPA Pesticide Factsheets

The wastewater treatment plant in Selbyville, Delaware, is benefitting from an EPA-Delaware partnership designed to help water and wastewater facilities save energy and money while cutting pollution that contributes to climate change.

Feasibility Study of Economics and Performance of Solar Photovoltaics at the Standard Chlorine of Delaware Superfund Site in Delaware City, Delaware. A Study Prepared in Partnership with the Environmental Protection Agency for the RE-Powering America's Land Initiative: Siting Renewable Energy on Potentially Contaminated Land and Mine Sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salasovich, J.; Geiger, J.; Mosey, G.

2013-06-01

The U.S. Environmental Protection Agency (EPA), in accordance with the RE-Powering America's Land initiative, selected the Standard Chlorine of Delaware site in Delaware City, Delaware, for a feasibility study of renewable energy production. The National Renewable Energy Laboratory (NREL) provided technical assistance for this project. The purpose of this report is to assess the site for a possible photovoltaic (PV) system installation and estimate the cost, performance, and site impacts of different PV options. In addition, the report recommends financing options that could assist in the implementation of a PV system at the site.

Prostate weight: an independent predictor for positive surgical margins during robotic-assisted laparoscopic radical prostatectomy.

PubMed

Msezane, Lambda P; Gofrit, Ofer N; Lin, Shang; Shalhav, Arieh L; Zagaja, Gregory P; Zorn, Kevin C

2007-10-01

Pre-operative prediction of pathological stage represents the cornerstone of prostate cancer management. Patient counseling is routinely based on pre-operative PSA, Gleason score and clinical stage. In this study, we evaluated whether prostate weight (PW) is an independent predictor of extracapsular extension (ECE) and positive surgical margin (PSM). Between February 2003 and November 2006, 709 men underwent robotic-assisted laparoscopic radical prostatectomy (RLRP). Pre-operative parameters (patient age, pre-operative PSA, biopsy Gleason score, clinical stage) as well as pathological data (prostate weight, pathological stage) were prospectively gathered after internal-review board (IRB) approval. Evaluation of the influence of these variables on ECE and PSM outcomes were assessed using both univariate and multivariate logistic regression analysis. Mean overall patient age, pre-operative PSA and PW were 59.6 years, 6.5 ng/ml and 52.9 g (range 5.5 g-198.7 g), respectively. Of the 393, 209 and 107 men with PW < 50 g, 50 g-< 70 g and < 70 g, ECE was observed in 20.1%, 15.3% and 9.3%, respectively (p = 0.015). In the same patient cohorts, PSM was observed in 25.4%, 14.4% and 7.5%, respectively (p < 0.001). In a multivariate logistic regression analysis, PW, in addition to pre-operative PSA, biopsy Gleason score and clinical stage, was an independent risk factor for ECE (p < 0.001). Similarly, in multi-variate analysis, PW was observed to be a risk factor for PSM (p < 0.001). PW is an independent predictor of both ECE and PSM, with an inverse relationship having been demonstrated between both variables. PW should be considered when counseling patients with prostate cancer treatment.

Effects of phosphoramidon on endothelin-1 and big endothelin-1 production in human aortic endothelial cells.

PubMed

Matsumura, Y; Tsukahara, Y; Kojima, T; Murata, S; Murakami, A; Takada, K; Takaoka, M; Morimoto, S

1995-03-01

Using cultured human aortic endothelial cells, we examined the effects of phosphoramidon, an endothelin converting enzyme (ECE) inhibitor, on the release of endogenous endothelin-1 (ET-1) and big endothelin-1 (big ET-1), and on the generation of ET-1 from exogenously applied big ET-1. Phosphoramidon, at concentrations of 10(-6) to 2 x 10(-4) M, caused a biphasic alteration of the ET-1 release, i.e., at lower concentrations of the drug, there were slight but unexpected increases of the release, whereas higher concentrations led to a decrease which is due to the drug-induced inhibition of ECE. The former effect appears to be based on the inhibition of ET-1 degradation by neutral endopeptidase 24.11 (NEP), since kelatorphan, a specific NEP inhibitor, produced a similar increasing effect on ET-1 release. Phosphoramidon enhanced the big ET-1 release from the cells in a concentration-dependent manner. When high concentrations of phosphoramidon were added, there was a dramatic increase in the release of big ET-1, which cannot be explained only by the drug-induced inhibition of ECE. This increase in big ET-1 release appeared to be partly due to a transient stimulation of the expression of prepro ET-1 mRNA. The amount of ET-1 generated from exogenously applied big ET-1 was markedly decreased by phosphoramidon in a concentration-dependent manner. In a similar fashion, phosphoramidon markedly inhibited ECE activity of the membrane fraction of cultured cells. Thus, ET-1 generation from exogenously applied big ET-1 reflects the functional phosphoramidon-sensitive ECE activities in human aortic endothelial cells.(ABSTRACT TRUNCATED AT 250 WORDS)

Extreme weather and climate events with ecological relevance: a review

PubMed Central

Meehl, Gerald A.

2017-01-01

Robust evidence exists that certain extreme weather and climate events, especially daily temperature and precipitation extremes, have changed in regard to intensity and frequency over recent decades. These changes have been linked to human-induced climate change, while the degree to which climate change impacts an individual extreme climate event (ECE) is more difficult to quantify. Rapid progress in event attribution has recently been made through improved understanding of observed and simulated climate variability, methods for event attribution and advances in numerical modelling. Attribution for extreme temperature events is stronger compared with other event types, notably those related to the hydrological cycle. Recent advances in the understanding of ECEs, both in observations and their representation in state-of-the-art climate models, open new opportunities for assessing their effect on human and natural systems. Improved spatial resolution in global climate models and advances in statistical and dynamical downscaling now provide climatic information at appropriate spatial and temporal scales. Together with the continued development of Earth System Models that simulate biogeochemical cycles and interactions with the biosphere at increasing complexity, these make it possible to develop a mechanistic understanding of how ECEs affect biological processes, ecosystem functioning and adaptation capabilities. Limitations in the observational network, both for physical climate system parameters and even more so for long-term ecological monitoring, have hampered progress in understanding bio-physical interactions across a range of scales. New opportunities for assessing how ECEs modulate ecosystem structure and functioning arise from better scientific understanding of ECEs coupled with technological advances in observing systems and instrumentation. This article is part of the themed issue ‘Behavioural, ecological and evolutionary responses to extreme climatic events’. PMID:28483866

Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor

PubMed Central

Murphy, Jane E.; Roosterman, Dirk; Cottrell, Graeme S.; Padilla, Benjamin E.; Feld, Micha; Brand, Eva; Cedron, Wendy J.; Steinhoff, Martin

2011-01-01

Activated G protein-coupled receptors (GPCRs) are phosphorylated and interact with β-arrestins, which mediate desensitization and endocytosis. Endothelin-converting enzyme-1 (ECE-1) degrades neuropeptides in endosomes and can promote recycling. Although endocytosis, dephosphorylation, and recycling are accepted mechanisms of receptor resensitization, a large proportion of desensitized receptors can remain at the cell surface. We investigated whether reactivation of noninternalized, desensitized (phosphorylated) receptors mediates resensitization of the substance P (SP) neurokinin 1 receptor (NK1R). Herein, we report a novel mechanism of resensitization by which protein phosphatase 2A (PP2A) is recruited to dephosphorylate noninternalized NK1R. A desensitizing concentration of SP reduced cell-surface SP binding sites by only 25%, and SP-induced Ca2+ signals were fully resensitized before cell-surface binding sites started to recover, suggesting resensitization of cell-surface-retained NK1R. SP induced association of β-arrestin1 and PP2A with noninternalized NK1R. β-Arrestin1 small interfering RNA knockdown prevented SP-induced association of cell-surface NK1R with PP2A, indicating that β-arrestin1 mediates this interaction. ECE-1 inhibition, by trapping β-arrestin1 in endosomes, also impeded SP-induced association of cell-surface NK1R with PP2A. Resensitization of NK1R signaling required both PP2A and ECE-1 activity. Thus, after stimulation with SP, PP2A interacts with noninternalized NK1R and mediates resensitization. PP2A interaction with NK1R requires β-arrestin1. ECE-1 promotes this process by releasing β-arrestin1 from NK1R in endosomes. These findings represent a novel mechanism of PP2A- and ECE-1-dependent resensitization of GPCRs. PMID:21795521

Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1.

PubMed

Carson, Julie A; Ansai, Toshihiro; Awano, Shuji; Yu, Weixian; Takehara, Tadamichi; Turner, Anthony J

2002-08-01

PgPepO is a homologue of endothelin-converting enzyme-1 (ECE-1), with which it shares 31% identity. PgPepO was isolated from the periodontal pathogen Porphyromonas gingivalis. Recent studies have suggested a link between periodontal and cardiovascular disease, and several groups have suggested that bacterial and viral infections may contribute to the latter. P. gingivalis possesses the ability to invade, and multiply within, aortic endothelial cells and has been localized to atherosclerotic plaques. PgPepO was expressed and purified to homogeneity and we have begun detailed functional analysis, in terms of substrate preference and inhibitor specificity, in order to provide active-site comparisons with other members of the neprilysin (NEP)/ECE family. PgPepO possesses similar substrate specificity to ECE-1 and has been shown to cleave big endothelin-1 (big ET-1), big ET-2 and big ET-3, converting the substrates into their respective mature endothelin peptides. Substance P, angiotensin I, angiotensin II and neurotensin are all cleaved at multiple sites by PgPepO and the kinetics of these reactions have been compared. The potent vasoconstrictor urotensin II is not hydrolysed by PgPepO. Cleavage of bradykinin by PgPepO occurs at the Pro(7)-Phe(8) bond and is inhibited by the NEP and ECE-1 inhibitor phosphoramidon in a pH-dependent fashion (IC(50) =10 microM at pH 7.0) but not by thiorphan, an NEP-specific inhibitor. PgPepO activity is completely inhibited by EDTA. Characterization of this enzyme is important in elucidating possible links between periodontal pathogens and cardiovascular disorders such as atherosclerosis, and provides an opportunity to gain structural information on a bacterial protein with striking similarity to human ECE-1.

Should reporting of peri-neural invasion and extra prostatic extension be mandatory in prostate cancer biopsies? correlation with outcome in biopsy cases treated conservatively

PubMed Central

Ahmad, Amar S.; Parameshwaran, Vishnu; Beltran, Luis; Fisher, Gabrielle; North, Bernard V.; Greenberg, David; Soosay, Geraldine; Møller, Henrik; Scardino, Peter; Cuzick, Jack; Berney, Daniel M.

2018-01-01

The identification of perineural invasion (PNI) and extraprostatic extension (ECE) in prostate cancer (PC) biopsies is time consuming and can be difficult. Although this is required information in many datasets, there is little evidence on their effect on outcome in patients treated conservatively. Cases of PC were identified from three cancer registries in the UK from men with clinically localized prostate cancer diagnosed by needle biopsy from 1990–2003. The endpoint was prostate cancer death (DOD). Patients treated radically within 6 months, those with objective evidence of metastases or who had prior hormone therapy were excluded. Follow-up was through cancer registries up until 2012. Deaths were divided into those from PC and those from other causes, according to WHO criteria. 988 biopsy cases (6522 biopsy cores) were centrally reviewed by three uropathologists and assigned a Gleason score and Grade Group (GG). The presence of both PNI and ECE was recorded. Of 988 patients, PNI was present in 288 (DOD = 75) and ECE in 23 (DOD = 5). On univariable analysis PNI was highly significantly associated with DOD (hazard ratio [HR] 2.28, 95% CI: 1.68, 3.1, log-rank test p-value = 4.8 × 10–8), but ECE was not (log-rank test p-value = 0.334). On multivariable analysis with GG, serum PSA (per 10%), clinical stage and extent of disease (per 10%), PNI lost significance (HR 1.16, 95% CI: 0.83, 1.63, likelihood ratio test p-value = 0.371). The utility of routinely examining prostate biopsies for ECE and PNI is doubtful as it is not independently associated with higher grade, stage or prognosis. PMID:29755671

Should reporting of peri-neural invasion and extra prostatic extension be mandatory in prostate cancer biopsies? correlation with outcome in biopsy cases treated conservatively.

PubMed

Ahmad, Amar S; Parameshwaran, Vishnu; Beltran, Luis; Fisher, Gabrielle; North, Bernard V; Greenberg, David; Soosay, Geraldine; Møller, Henrik; Scardino, Peter; Cuzick, Jack; Berney, Daniel M

2018-04-17

The identification of perineural invasion (PNI) and extraprostatic extension (ECE) in prostate cancer (PC) biopsies is time consuming and can be difficult. Although this is required information in many datasets, there is little evidence on their effect on outcome in patients treated conservatively. Cases of PC were identified from three cancer registries in the UK from men with clinically localized prostate cancer diagnosed by needle biopsy from 1990-2003. The endpoint was prostate cancer death (DOD). Patients treated radically within 6 months, those with objective evidence of metastases or who had prior hormone therapy were excluded. Follow-up was through cancer registries up until 2012. Deaths were divided into those from PC and those from other causes, according to WHO criteria. 988 biopsy cases (6522 biopsy cores) were centrally reviewed by three uropathologists and assigned a Gleason score and Grade Group (GG). The presence of both PNI and ECE was recorded. Of 988 patients, PNI was present in 288 (DOD = 75) and ECE in 23 (DOD = 5). On univariable analysis PNI was highly significantly associated with DOD (hazard ratio [HR] 2.28, 95% CI: 1.68, 3.1, log-rank test p -value = 4.8 × 10 -8 ), but ECE was not (log-rank test p -value = 0.334). On multivariable analysis with GG, serum PSA (per 10%), clinical stage and extent of disease (per 10%), PNI lost significance (HR 1.16, 95% CI: 0.83, 1.63, likelihood ratio test p -value = 0.371). The utility of routinely examining prostate biopsies for ECE and PNI is doubtful as it is not independently associated with higher grade, stage or prognosis.

Extreme weather and climate events with ecological relevance: a review.

PubMed

Ummenhofer, Caroline C; Meehl, Gerald A

2017-06-19

Robust evidence exists that certain extreme weather and climate events, especially daily temperature and precipitation extremes, have changed in regard to intensity and frequency over recent decades. These changes have been linked to human-induced climate change, while the degree to which climate change impacts an individual extreme climate event (ECE) is more difficult to quantify. Rapid progress in event attribution has recently been made through improved understanding of observed and simulated climate variability, methods for event attribution and advances in numerical modelling. Attribution for extreme temperature events is stronger compared with other event types, notably those related to the hydrological cycle. Recent advances in the understanding of ECEs, both in observations and their representation in state-of-the-art climate models, open new opportunities for assessing their effect on human and natural systems. Improved spatial resolution in global climate models and advances in statistical and dynamical downscaling now provide climatic information at appropriate spatial and temporal scales. Together with the continued development of Earth System Models that simulate biogeochemical cycles and interactions with the biosphere at increasing complexity, these make it possible to develop a mechanistic understanding of how ECEs affect biological processes, ecosystem functioning and adaptation capabilities. Limitations in the observational network, both for physical climate system parameters and even more so for long-term ecological monitoring, have hampered progress in understanding bio-physical interactions across a range of scales. New opportunities for assessing how ECEs modulate ecosystem structure and functioning arise from better scientific understanding of ECEs coupled with technological advances in observing systems and instrumentation.This article is part of the themed issue 'Behavioural, ecological and evolutionary responses to extreme climatic events'. © 2017 The Author(s).

Quantification and probabilistic modeling of CRT obsolescence for the State of Delaware.

PubMed

Schumacher, Kelsea A; Schumacher, Thomas; Agbemabiese, Lawrence

2014-11-01

The cessation of production and replacement of cathode ray tube (CRT) displays with flat screen displays have resulted in the proliferation of CRTs in the electronic waste (e-waste) recycle stream. However, due to the nature of the technology and presence of hazardous components such as lead, CRTs are the most challenging of electronic components to recycle. In the State of Delaware it is due to this challenge and the resulting expense combined with the large quantities of CRTs in the recycle stream that electronic recyclers now charge to accept Delaware's e-waste. Therefore it is imperative that the Delaware Solid Waste Authority (DSWA) understand future quantities of CRTs entering the waste stream. This study presents the results of an assessment of CRT obsolescence in the State of Delaware. A prediction model was created utilizing publicized sales data, a variety of lifespan data as well as historic Delaware CRT collection rates. Both a deterministic and a probabilistic approach using Monte Carlo Simulation (MCS) were performed to forecast rates of CRT obsolescence to be anticipated in the State of Delaware. Results indicate that the peak of CRT obsolescence in Delaware has already passed, although CRTs are anticipated to enter the waste stream likely until 2033. Copyright © 2014 Elsevier Ltd. All rights reserved.

Avian influenza in shorebirds: experimental infection of ruddy turnstones (Arenaria interpres) with avian influenza virus

USGS Publications Warehouse

Hall, Jeffrey S.; Krauss, Scott; Franson, J. Christian; TeSlaa, Joshua L.; Nashold, Sean W.; Stallknecht, David E.; Webby, Richard J.; Webster, Robert G.

2013-01-01

Background: Low pathogenic avian influenza viruses (LPAIV) have been reported in shorebirds, especially at Delaware Bay, USA, during spring migration. However, data on patterns of virus excretion, minimal infectious doses, and clinical outcome are lacking. The ruddy turnstone (Arenaria interpres) is the shorebird species with the highest prevalence of influenza virus at Delaware Bay. Objectives: The primary objective of this study was to experimentally assess the patterns of influenza virus excretion, minimal infectious doses, and clinical outcome in ruddy turnstones. Methods: We experimentally challenged ruddy turnstones using a common LPAIV shorebird isolate, an LPAIV waterfowl isolate, or a highly pathogenic H5N1 avian influenza virus. Cloacal and oral swabs and sera were analyzed from each bird. Results: Most ruddy turnstones had pre-existing antibodies to avian influenza virus, and many were infected at the time of capture. The infectious doses for each challenge virus were similar (103·6–104·16 EID50), regardless of exposure history. All infected birds excreted similar amounts of virus and showed no clinical signs of disease or mortality. Influenza A-specific antibodies remained detectable for at least 2 months after inoculation. Conclusions: These results provide a reference for interpretation of surveillance data, modeling, and predicting the risks of avian influenza transmission and movement in these important hosts.

43. BOILER HOUSE FOURTH FLOOR, CLOSER VIEW OF STACKS, FORCED ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. BOILER HOUSE FOURTH FLOOR, CLOSER VIEW OF STACKS, FORCED DRAFT FANS, AND COAL BUNKER - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

The Role of Access to Head Start and Quality Ratings for Spanish-Speaking Dual Language Learners’ (DLLs) Participation in Early Childhood Education

PubMed Central

2014-01-01

Data from the Head Start Impact Study (N = 4,442) were used to test for differences between Spanish-speaking Dual Language Learners (DLLs) and monolingual English-speaking children in: (1) Head Start attendance rates when randomly assigned admission; and (2) quality ratings of other early childhood education (ECE) programs attended when not randomly assigned admission to Head Start. Logistic regressions showed that Spanish-speaking DLL children randomly assigned a spot in Head Start were more likely than monolingual-English learners to attend. Further, Spanish-speaking DLLs not randomly assigned a spot in Head Start were more likely to attend higher-quality ECE centers than non-DLL children. Policy implications are discussed, suggesting that, if given access, Spanish-speaking DLL families will take advantage of quality ECE programs. PMID:25018585

Flood of April 2-4, 2005, Delaware River Main Stem from Port Jervis, New York, to Cinnaminson, New Jersey

USGS Publications Warehouse

Reed, Timothy J.; Protz, Amy R.

2007-01-01

Several conditions, including saturated soils, snowmelt, and heavy rains, caused flooding on the Delaware River on April 2-4, 2005. The event occurred 50 years after the historic 1955 Delaware River flood, and only six months after a smaller but equally notable flood on September 18-19, 2004. The Delaware River flooded for a third time in 22 months in June, 2006. The peak flows and elevations of the 2005 flood were similar to those on June 28-29, 2006. The following report describes the April 2-4, 2005, Delaware River flood, and includes the associated precipitation amounts, peak flows and elevations, and flood frequencies. A comparison of historic Delaware River floods also is presented. The appendix of the report contains detailed information for 156 high-water mark elevations obtained on the main stem of the Delaware River from Port Jervis, New York, to Cinnaminson, New Jersey, for the April 2-4, 2005 flood. The April 2005 event originated with frequent precipitation from December 2004 to March 2005 which saturated the soils in the upper Delaware River Basin. The cold winter froze some of the soils and left a snowpack at higher elevations equivalent to as much as 10 inches of water in some areas. Temperatures rose above freezing, and heavy rains averaging 1 to 3 inches on March 27, 2005, melted some of the snow, causing the Delaware River to rise; however, peak elevations were still 2 to 7 feet below flood stage. Another round of rainfall averaging 2-5 inches in the basin on April 2, 2005, melted the remaining snowpack. The combination of snowmelt and runoff from the two storms produced flood conditions along the main stem of the Delaware River. Flood frequencies of flows at selected tributaries to the Delaware River did not exceed the 35-year recurrence intervals. The Delaware River main stem peak-flow recurrence intervals ranged from 40 to 80 years; flows were approximately 20 percent less than those from the peak of record in 1955. Peak elevations exceeded National Weather Service flood stages defined at continuous-record streamflow-gaging stations by 5 to 7 feet, but were on average 3 to 5 feet lower than the peak of record in August 1955. Peak elevations determined at 48 sites along the main stem of the Delaware River defined the flood profile between the gaging stations. The peak elevation in the tide-effected portion of the Delaware (downstream of Trenton, New Jersey), occurred on April 2, 2 days before the riverine peak, as a result of water pushed into the bay by a low-pressure system situated just off the coast. Every county located along the main stem of the Delaware River was declared a Federal disaster area. Property damage estimates in Pennsylvania, New York, and New Jersey exceeded $200 million.

Using State Early Care and Education Workforce Registry Data to Inform Training-Related Questions: Issues to Consider. Research Report. ETS RR-16-31

ERIC Educational Resources Information Center

Ackerman, Debra J.

2016-01-01

The current early care and education (ECE) policy context is bringing increased attention to the training completed by the child care workforce and to the use of registries to track such training. Although ECE workforce registries are designed to record individuals' data, aggregate registry data have the potential to shed light on the workforce's…

The ECE Culminating Design Experience: Analysis of ABET 2000 Compliance at Leading Academic Institutions

DTIC Science & Technology

2006-05-01

a significant design project that requires development of a large scale software project . A distinct shortcoming of Purdue ECE...18-540: Rapid Prototyping of Computer Systems This is a project -oriented course which will deal with all four aspects of project development ; the...instructors, will develop specifications for a mobile computer to assist in inspection and maintenance. The application will be partitioned

Towards Resilient Information-Aware Communication Networks

DTIC Science & Technology

2013-02-01

kPa) kilo pascal (kPa) kilogram (kg) kilogram-meter 2 (kg-m2) kilogram-meter 3 (kg/m 3 ) **Gray (Gy) coulomb /kilogram (C/kg) second (s...Dept. of ECE). Iowa State University Collaborated with Prof. Lei Ying (Dep. of ECE). Massachusetts Institute of Technology Collaborated with Prof...courses on De - sign and Analysis of Communication Networks and also supervised students in a Smart Phone labo- ratory during this period. Both the

42. BOILER HOUSE FOURTH FLOOR, FORCED DRAFT FANS ABOVE BOILERS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. BOILER HOUSE FOURTH FLOOR, FORCED DRAFT FANS ABOVE BOILERS (SEE DRAWING Nos. 10 & 11 OF 13) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

76. TURBINE HALL, UNIT 2 SHOWING BOTH TURBINE AND CONDENSER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

76. TURBINE HALL, UNIT 2 SHOWING BOTH TURBINE AND CONDENSER (SEE ALSO, DRAWING No. 12 OF 13) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

Delaware's annual traffic statistical report, 2010

DOT National Transportation Integrated Search

2011-01-01

The Traffic Control Section of the Delaware State Police is the repository for all Delaware traffic crash data. This includes all crash reports regardless of the geographical areas in which they occur or the policy agency conducting the investigation...

Delaware's annual traffic statistical report, 2005

DOT National Transportation Integrated Search

2006-04-10

The Traffic Control Section of the Delaware State Police is the repository for all Delaware traffic crash data. This includes all crash reports regardless of the geographical areas in which they occur or the policy agency conducting the investigation...

Delaware's annual traffic statistical report, 2007

DOT National Transportation Integrated Search

2007-01-01

The Traffic Control Section of the Delaware State Police is the repository for all Delaware traffic crash data. This includes all crash reports regardless of the geographical areas in which they occur or the policy agency conducting the investigation...

Delaware's annual traffic statistical report, 2006

DOT National Transportation Integrated Search

2006-01-01

The Traffic Control Section of the Delaware State Police is the repository for all Delaware traffic crash data. This includes all crash reports regardless of the geographical areas in which they occur or the policy agency conducting the investigation...

Delaware's annual traffic statistical report, 2009

DOT National Transportation Integrated Search

2010-04-12

The Traffic Control Section of the Delaware State Police is the repository for all Delaware traffic crash data. This includes all crash reports regardless of the geographical areas in which they occur or the policy agency conducting the investigation...

Delaware's annual traffic statistical report, 2011

DOT National Transportation Integrated Search

2012-01-01

The Traffic Control Section of the Delaware State Police is the repository for all Delaware traffic crash data. This includes all crash reports regardless of the geographical areas in which they occur or the policy agency conducting the investigation...

Delaware's annual traffic statistical report, 2008

DOT National Transportation Integrated Search

2009-04-13

The Traffic Control Section of the Delaware State Police is the repository for all Delaware traffic crash data. This includes all crash reports regardless of the geographical areas in which they occur or the policy agency conducting the investigation...

2. CANAL BOAT ENTERING THE DELAWARE CANAL FROM OF THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. CANAL BOAT ENTERING THE DELAWARE CANAL FROM OF THE LEHIGH RIVER. BOATS COULD BE FERRIED ACROSS THE DELAWARE RIVER TO THE MORRIS CANAL BY A CABLE SUPPORTED TROLLEY. - Morris Canal, Phillipsburg, Warren County, NJ

Health and safety needs in early care and education programs: what do directors, child health records, and national standards tell us?

PubMed

Alkon, Abbey; To, Kim; Mackie, Joanna F; Wolff, Mimi; Bernzweig, Jane

2010-01-01

To identify the overlapping and unique health and safety needs and concerns identified by early care and education (ECE) directors, health records, and observed compliance with national health and safety (NHS) standards. Cross-sectional study. 127 ECE programs from 5 California counties participated in the study, including 118 directors and 2,498 children's health records. Qualitative data were collected using standardized ECE directors' interviews to identify their health and safety concerns; and objective, quantitative data were collected using child health record reviews to assess regular health care, immunizations, health insurance, special health care needs, and screening tests and an observation Checklist of 66 key NHS standards collected by research assistants. The overlapping health and safety needs and concerns identified by the directors and through observations were hygiene and handwashing, sanitation and disinfection, supervision, and the safety of indoor and outdoor equipment. Some of the health and safety needs identified by only one assessment method were health and safety staff training, medical plans for children with special health care needs and follow-up on positive screening tests. Comprehensive, multimethod assessments are useful to identify health and safety needs and develop public health nursing interventions for ECE programs.

Embedded Cohesive Elements (ECE) Approach to the Simulation of Spall Fracture Experiment

NASA Astrophysics Data System (ADS)

Bonora, Nicola; Esposito, Luca; Ruggiero, Andrew

2007-06-01

Discrepancies between the calculated and observed velocity vs time plot, relatively to the spall signal portion in terms of both signal amplitude and frequency, in numerical simulations of flyer plate impact test are usually shown. These are often ascribed either to material model or the numerical scheme used. Bonora et al. (2003 )[Bonora N., Ruggiero A. and Milella P.P., 2003, Fracture energy effect on spall signal, Proc. of 13^th APS SCCM03, Portland, USA] showed that, for ductile metals, these differences can be the imputed to the dissipation process during fracturing due to the viscous separation of spall fracture plane surfaces. In this work that concept has been further developed implementing an embedded cohesive elements (ECE) technology into FEM. The ECE method consists in embedding cohesive elements (normal and shear forces only) into standard isoparametric 2D or 3D FEM continuum elements. The cohesive elements remain silent and inactive until the continuum element fails. At failure, the continuum element is removed while the ECE becomes active until the separation energy is dissipated. Here, the methodology is presented and applied to simulate soft spall in ductile metals such as OHFC copper. Results of parametric study on mesh size and cohesive law shape effect are presented.

Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed.

PubMed

Cho, Suengmok; Han, Daeseok; Kim, Seon-Bong; Yoon, Minseok; Yang, Hyejin; Jin, Young-Ho; Jo, Jinho; Yong, Hyeim; Lee, Sang-Hoon; Jeon, You-Jin; Shimizu, Makoto

2012-01-01

Marine plants have been reported to possess various pharmacological properties; however, there have been few reports on their neuropharmacological effects. Terrestrial plants have depressive effects on the central nervous system (CNS) because of their polyphenols which make them effective as anticonvulsants and sleep inducers. We investigated in this study the depressive effects of the polyphenol-rich brown seaweed, Ecklonia cava (EC), on CNS. An EC enzymatic extract (ECEE) showed significant anticonvulsive (>500 mg/kg) and sleep-inducing (>500 mg/kg) effects on the respective mice seizure induced by picrotoxin and on the mice sleep induced by pentobarbital. The phlorotannin-rich fraction (PTRF) from ECEE significantly potentiated the pentobarbital-induced sleep at >50 mg/kg. PTRF had binding activity to the gamma aminobutyric acid type A (GABA(A))-benzodiazepine (BZD) receptors. The sleep-inducing effects of diazepam (DZP, a well-known GABA(A)-BZD agonist), ECEE, and PTRF were completely blocked by flumazenil, a well-known antagonist of GABA(A)-BZD receptors. These results imply that ECEE produced depressive effects on CNS by positive allosteric modulation of its phlorotannins on GABA(A)-BZD receptors like DZP. Our study proposes EC as a candidate for the effective treatment of neuropsychiatric disorders such as anxiety and insomnia.

Preclinical students’ experiences in early clerkships after skills training partly offered in primary health care centers: a qualitative study from Indonesia

PubMed Central

2012-01-01

Background Students may encounter difficulties when they have to apply clinical skills trained in their pre-clinical studies in clerkships. Early clinical exposure in the pre-clinical phase has been recommended to reduce these transition problems. The aim of this study is to explore differences in students' experiences during the first clerkships between students exclusively trained in a skills laboratory and peers for whom part of their skills training was substituted by early clinical experiences (ECE). Methods Thirty pre-clinical students trained clinical skills exclusively in a skills laboratory; 30 peers received part of their skills training in PHC centers. Within half a year after commencing their clerkships all 60 students shared their experiences in focus group discussions (FGDs). Verbatim transcripts of FGDs were analyzed using Atlas-Ti software. Results Clerkship students who had participated in ECE in PHC centers felt better prepared to perform their clinical skills during the first clerkships than peers who had only practiced in a skills laboratory. ECE in PHC centers impacted positively in particular on students’ confidence, clinical reasoning, and interpersonal communication. Conclusion In the Indonesian setting ECE in PHC centers reduce difficulties commonly encountered by medical students in the first clerkships. PMID:22640419

Collective Bargaining Agreement between the Board of Trustees of Delaware State College and the Delaware State College Chapter of the American Association of University Professors, September 1, 1983-August 31, 1986.

ERIC Educational Resources Information Center

Delaware State Coll., Dover.

The collective bargaining agreement between the Delaware State College Board of Trustees and the Delaware State College Chapter (145 members) of the American Association of University Professors covering the period September 1, 1983-August 31, 1986 is presented. Items covered in the agreement include: unit recognition and definitions,…

45. BOILER HOUSE BETWEEN FOURTH AND FIRST FLOORS SHOWING COAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. BOILER HOUSE BETWEEN FOURTH AND FIRST FLOORS SHOWING COAL BUNKER AND COAL FEEDER PIPES, LOOKING FROM CATWALK - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

23. DETAIL VIEW IN COAL TOWER No. 1 (WEST) OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. DETAIL VIEW IN COAL TOWER No. 1 (WEST) OF THE MECHANISM THAT OPERATES THE COAL BUCKETS, FACING NORTH - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

78 FR 14784 - Delaware Division of the Public Advocate, Delaware Municipal Electric Corporation, Inc., Delaware...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-07

... against Baltimore Gas and Electric Company (BGE), Pepco Holdings, Inc. (PHI), and affiliates; Potomac...), seeking a Commission order to reduce the base return equity used in BGE's and PHI Companies' formula...

27. BOILER HOUSE, GENERAL VIEW LOOKING SOUTH, PAST COAL CAR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. BOILER HOUSE, GENERAL VIEW LOOKING SOUTH, PAST COAL CAR No. 9 TOWARD COAL CARS No. 11 & 8 - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

Transportation elements assessment : Town of Milton, Delaware, September 29, 2009.

DOT National Transportation Integrated Search

2009-09-29

During the summer of 2009, the Delaware T2 Center collected extensive data : and completed analyses related to transportation infrastructure in the Town : of Milton, Delaware. This report presents those data, the analyses, and : resulting recommendat...

68. TURBINE HALL, LOOKING DOWN FROM THE CONTROL ROOM INTO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

68. TURBINE HALL, LOOKING DOWN FROM THE CONTROL ROOM INTO TURBINE HALL AT UNITS 3, 5, AND 2) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

Assessing the needs of Delaware's older drivers.

DOT National Transportation Integrated Search

2007-06-01

In light of Delawares growing population age 60 and older (60+), it is important to plan for the : states projected increase in older drivers. Information from the United States Census Bureau : (2005) indicates that Delaware is projected to hav...

15. VIEW OF COAL TOWER No. 2, LOOKING WEST TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. VIEW OF COAL TOWER No. 2, LOOKING WEST TO EAST FROM COAL TOWER No. 1 (FLOOR BELOW CRANE CONTROL) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

44. BOILER HOUSE FOURTH FLOOR, GENERAL VIEW OF BASE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. BOILER HOUSE FOURTH FLOOR, GENERAL VIEW OF BASE OF STACKS, FORCED DRAFT FANS, AND COAL BUNKER LOOKING TO COAL BUNKER - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

24. DETAIL VIEW IN COAL TOWER No. 1 OF THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. DETAIL VIEW IN COAL TOWER No. 1 OF THE LEVERS THAT MANIPULATE THE COAL BUCKETS, LOOKING OVER THE BOOM - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

35. BOILER HOUSE, TRACK FOR COAL CARS LEADING TO COAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

35. BOILER HOUSE, TRACK FOR COAL CARS LEADING TO COAL TOWER No. 2 (NOTE: SKYLIGHT ABOVE; COAL CARS IN FAR BACKGROUND) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

34. BOILER HOUSE, COAL CONVEYOR AND TURNAROUND TRACK FOR COAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. BOILER HOUSE, COAL CONVEYOR AND TURN-AROUND TRACK FOR COAL CARS (NOTE: COAL CAR No. 6 IN FAR BACK GROUND) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

39. BOILER HOUSE, COAL CONVEYOR LEADING FROM COAL TOWER No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

39. BOILER HOUSE, COAL CONVEYOR LEADING FROM COAL TOWER No. 1 (WEST) (NOTE: COAL CARS No. 9 & 5 IN BACKGROUND) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

Which Early Care and Education Centers Participate in Head Start or Public Pre-Kindergarten? National Survey of Early Care & Education. Technical Report. OPRE Report 2015-92a

ERIC Educational Resources Information Center

Administration for Children & Families, 2015

2015-01-01

This report draws on newly available data from the National Survey of Early Care and Education (NSECE) to describe early care and education (ECE) centers that participate in two prominent publicly-funded ECE initiatives: Head Start and publicly-funded pre-kindergarten. Although a great deal is known about Head Start programs, and there are sources…

Early Education and Care: Overlap Indicates Need To Assess Crosscutting Programs. Report to the Chairman, Subcommittee on Oversight of Government Management, Restructuring and the District of Columbia, U.S. Senate.

ERIC Educational Resources Information Center

Shaul, Marnie S.

In response to Congressional requests reflecting the nationwide attention on early childhood education (ECE) and care, the General Accounting Office assessed the federally funded programs that provide or support ECE and care for children under 5 years. Information was obtained by means of an electronic search of the June 1999 Catalog of Federal…

A Guide to Nuclear Weapons Phenomena and Effects Literature

DTIC Science & Technology

1984-10-31

and Disarmament Agency. An article entitled "Limited Nuclear War" in Scientific American (Reference ECE-14) is also of interest because of its rela... Sistems and the Aemosphere’-BCj=9. 43 Personne l; .-EP)- / 47 Civilian .S’ector and the .Environment, (ECE) 50 5 SPECIAL REFERENCE MATERIALS (R) ’<ൾ...approximations. DNA has sponsored the development of software for scientific and military applications of nuclear weapon phenomena and effects information

Investigation of factors influencing chloride extraction efficiency during electrochemical chloride extraction from reinforcing concrete

NASA Astrophysics Data System (ADS)

Sharp, Stephen R.

2005-11-01

Electrochemical chloride extraction (ECE) is an accelerated bridge restoration method similar to cathodic protection, but operates at higher current densities and utilizes a temporary installation. Both techniques prolong the life of a bridge by reducing the corrosion rate of the reinforcing bar when properly applied. ECE achieves this by moving chlorides away from the reinforcement and out of the concrete while simultaneously increasing the alkalinity of the electrolyte near the reinforcing steel. Despite the proven success, significant use of ECE has not resulted in part due to an incomplete understanding in the following areas: (1) An estimation of the additional service life that can be expected following treatment when the treated member is again subjected to chlorides; (2) The cause of the decrease in current flow and, therefore, chloride removal rate during treatment; (3) Influence of water-to-cement (w/c) ratio and cover depth on the time required for treatment. This dissertation covers the research that is connected to the last two areas listed above. To begin examining these issues, plain carbon steel reinforcing bars (rebar) were embedded in portland cement concrete slabs of varying water-to-cement (w/c) ratios and cover depths, and then exposed to chlorides. A fraction of these slabs had sodium chloride added as an admixture, with all of the slabs subjected to cyclical ponding with a saturated solution of sodium chloride. ECE was then used to remove the chlorides from these slabs while making electrical measurements in the different layers between the rebar (cathode) and the titanium mat (anode) to follow the progress of the ECE process. During this study, it was revealed that the resistance of the outer concrete surface layer increases during ECE, inevitably restricting current flow, while the resistance of the underlying concrete decreases or remains constant. During ECE treatment, a white residue formed on the surface of the concrete. Analyses of the residue revealed that it contains calcium carbonate, calcium chloride, and other yet unidentified minor components when calcium hydroxide was used as the electrolyte. The surface film can be completely removed mechanically or to some extent inhibited chemically, with both of these processes resulting in an increase in the efficiency of the electrochemical chloride extraction process. In addition, an obvious relationship between the cover depth, water-to-cement ratio, and chloride extraction efficiency does not exist, however, cover depth does influence the current density. The final phase of this study will be presented in a VTRC/FHWA final report. This report will include the results that are presented in this dissertation, in addition to the results from the ongoing research. It will also include an estimation of the additional service life that can be expected following treatment.

14. WEST ELEVATION OF COAL TOWER No. 2, LOOKING WEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. WEST ELEVATION OF COAL TOWER No. 2, LOOKING WEST TO EAST FROM COAL TOWER No. 1 (FLOOR BELOW THE CRANE CONTROL) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

DELAWARE ESTUARY PCB MODEL

EPA Science Inventory

The Delaware River Basin Commission recently completed the first phase of a program to develop and implement Total Maximum Daily Loads (TMDLs) for toxic pollutants for the Delaware Estuary. This complex body of water extends from the head of tide at Trenton, NJ (River Mile 133.2...

76 FR 62132 - Delaware Disaster #DE-00009

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12864 and 12865] Delaware Disaster DE-00009 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Delaware dated 09/29/2011. Incident: Hurricane Irene...

Fire prevention in Delaware: a case study of fire and life safety initiatives.

PubMed

Frattaroli, Shannon; Gielen, Andrea C; Piver-Renna, Jennifer; Pollack, Keshia M; Ta, Van M

2011-01-01

Injuries resulting from residential house fires are a significant public health issue. The fire service is engaged in fire prevention activities aimed at preventing fire-related morbidity and mortality. The fire service in Delaware is regarded by some leaders in the field as a model for fire and life safety education (FLSE). We identified 3 questions to guide this research. What is the culture and context of fire prevention in Delaware? What prevention programs and policies constitute Delaware's fire prevention efforts? What can be learned from select model programs regarding their impact, sustainability, strengths, limitations, and general applicability? A discussion of the lessons learned from Delaware's experience with FLSE initiatives concludes the article. We used a single case study design and collected and analyzed data from in-depth interviews, documents, and participant observation notes to address the research questions. Data were collected in Delaware. Interviewees included a purposeful sample of members of the Delaware fire service. Descriptions of the context in which fire prevention occurs, the initiatives underway, and the factors associated with successfully supporting fire prevention in the state. Data from 16 key informant interviews, relevant documents, and direct observations of FLSE events revealed a fire service rooted in tradition, dedication, and community. A compilation of state and local FLSE initiatives illustrates the diversity of FLSE in Delaware. Thematic analysis of the data emphasize the importance of a strategic, comprehensive, and coordinated approach to realizing success in Delaware's approach to FLSE. The fire service is an important part of the public health infrastructure. While their role as first responders is evident, their contributions to prevention are also significant. This research suggests ways to support fire service prevention efforts and more fully integrate their FLSE work into the public health infrastructure.

Effects of laughing gull and shorebird predation on the intertidal fauna at Cape May, New Jersey

NASA Astrophysics Data System (ADS)

Botton, M. L.

1984-02-01

The intertidal flats of the Cape May, New Jersey shore of Delaware Bay are populated by large numbers of laughing gulls and migrating shorebirds during the spring and early summer. Exclusion of birds from a shallow slough and a sand bar had only minor effects on the infaunal benthic invertebrate assemblage at either site. The Cape May beaches provide a rich source of food in the form of horseshoe crab ( Limulus polyphemus) eggs; foraging on this item may be more profitable than probing the sediment for infauna. Gemma gemma, a small, thick-shelled bivalve, composed over 98% of the benthic infauna at both sites in 1980, and this species may be resistant to predation by certain shorebirds, as suggested by Schneider (1978).

40. BOILER HOUSE, BEGINNING OF COAL CONVEYOR FROM COAL TOWER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. BOILER HOUSE, BEGINNING OF COAL CONVEYOR FROM COAL TOWER No. 1 (FIFTH FLOOR OR CABLE ROAD FLOOR SHOWN IN DRAWING No. 6 OF 13) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

40 CFR 52.465 - Original identification of plan section.

Code of Federal Regulations, 2012 CFR

2012-07-01

... through XIV inclusive of the Delaware Regulations Governing Air Pollution, and Amendments to the Delaware... Plan, covering changes to the air pollution monitoring system; submitted on September 3, 1975 by the..., consisting of an amendment to Delaware Regulations Governing Air Pollution, Regulation XVII, establishing...

40 CFR 52.465 - Original identification of plan section.

Code of Federal Regulations, 2010 CFR

2010-07-01

... through XIV inclusive of the Delaware Regulations Governing Air Pollution, and Amendments to the Delaware... Plan, covering changes to the air pollution monitoring system; submitted on September 3, 1975 by the..., consisting of an amendment to Delaware Regulations Governing Air Pollution, Regulation XVII, establishing...

40 CFR 52.465 - Original identification of plan section.

Code of Federal Regulations, 2011 CFR

2011-07-01

... through XIV inclusive of the Delaware Regulations Governing Air Pollution, and Amendments to the Delaware... Plan, covering changes to the air pollution monitoring system; submitted on September 3, 1975 by the..., consisting of an amendment to Delaware Regulations Governing Air Pollution, Regulation XVII, establishing...

Nutrient Enrichment Study Data from the Upper, Middle, and Lower Sections of the Non-Tidal Delaware River, 2009

USGS Publications Warehouse

Brightbill, Robin A.; Limbeck, Robert; Silldorff, Erik; Eggleston, Heather L.

2011-01-01

The Delaware River Basin Commission is charged with establishing water-quality objectives for the tidal and non-tidal portions of the Delaware River, which include developing nutrient standards that are scientifically defensible. The U.S. Geological Survey, in cooperation with the Delaware River Basin Commission and the Academy of Natural Sciences, studied the effects of nutrient enrichment in the upper, middle, and lower sections of the non-tidal Delaware River. Algal samples were collected from the natural habitat using rock scrapes and from the artificial nutrient enrichment samplers, Matlock periphytometers. The knowledge gained from this study is to be used in helping determine appropriate nutrient criteria for the Delaware River in the oligotrophic, mesotrophic, and eutrophic sections of the river and is a first step toward gathering data that can be used in selecting nutrient effect levels or criteria thresholds for aquatic-life use protection. This report describes the methods for data collection and presents the data collected as part of this study.

Effects of the ECE/NEP inhibitor CGS 34225 on the big ET-1-induced pressor response and plasma atrial natriuretic peptide concentration in conscious rats.

PubMed

Trapani, Angelo J; Beil, Michael E; Bruseo, Charles W; Fink, Cynthia A; Hoyer, Denton; Savage, Paula; Jeng, Arco Y

2002-08-01

CGS 34226 is a thiol-containing, potent dual inhibitor of endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase 24.11 (NEP) with IC(50) values of 11 and 5 nM respectively. The purpose of the present study was to characterize the inhibitory effects of CGS 34225, an orally active prodrug of CGS 34226, on ECE-1 and NEP in vivo. The effects on ECE-1 and NEP were assessed by determining the inhibition of big endothelin-1 (big ET-1)-induced increases in mean arterial pressure (MAP) and increases in plasma atrial natriuretic peptide (ANP) concentrations respectively, in conscious rats. Thirty and 120 min after the administration of vehicle, big ET-1 (0.3 nmol/kg, intravenously; i.v.) produced pressor responses of approximately 800 mmHg.min (area under the curve for change in MAPxtime). Treatment with CGS 34225 at 1 mgEq/kg, per os (p.o.), decreased the pressor effect of big ET-1 by 39 and 53% at 30 and 120 min respectively (P<0.05, both times). Increasing the dose of CGS 34255 to 30 mgEq/kg, p.o., resulted in greater inhibition, 84 and 92% (P<0.05) at 30 and 120 min respectively. Furthermore, at this higher dose, the inhibitory effect on ECE-1 was long-lasting, averaging 86, 75 and 30% (P<0.05, all times) at 4, 8 and 24 h respectively. In rats treated with vehicle, the infusion of ANP at 450 ng/kg per min i.v. resulted in plasma ANP concentrations of 3.9-4.8 ng/ml that remained relatively constant for 4 h. Treatment with CGS 34225 at 10 mgEq/kg, p.o., increased the ANP level to 7.7+/-1.0 and 10.6+/-1.8 ng/ml at 1 and 4 h after dosing (P<0.05, both times). These data demonstrate that CGS 34225 is a potent, orally active and long-acting inhibitor of ECE-1 and NEP in vivo. It is anticipated that compounds with this dual function may be useful in the treatment of cardiovascular diseases where the ET system plays a pathogenic role and the potentiation of ANP elicits therapeutic benefits.

Impact of Postmastectomy Radiation on Locoregional Recurrence in Breast Cancer Patients With 1-3 Positive Lymph Nodes Treated With Modern Systemic Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tendulkar, Rahul D., E-mail: tendulr@ccf.org; Rehman, Sana; Shukla, Monica E.

2012-08-01

Purpose: Postmastectomy radiation therapy (PMRT) remains controversial for patients with 1-3 positive lymph nodes (LN+). Methods and Materials: We conducted a retrospective review of all 369 breast cancer patients with 1-3 LN+ who underwent mastectomy without neoadjuvant systemic therapy between 2000 and 2007 at Cleveland Clinic. Results: We identified 271 patients with 1-3 LN+ who did not receive PMRT and 98 who did receive PMRT. The median follow-up time was 5.2 years, and the median number of LN dissected was 11. Of those not treated with PMRT, 79% received adjuvant chemotherapy (of whom 70% received a taxane), 79% received hormonalmore » therapy, and 5% had no systemic therapy. Of the Her2/neu amplified tumors, 42% received trastuzumab. The 5-year rate of locoregional recurrence (LRR) was 8.9% without PMRT vs 0% with PMRT (P=.004). For patients who did not receive PMRT, univariate analysis showed 6 risk factors significantly (P<.05) correlated with LRR: estrogen receptor/progesterone receptor negative (hazard ratio [HR] 2.6), lymphovascular invasion (HR 2.4), 2-3 LN+ (HR 2.6), nodal ratio >25% (HR 2.7), extracapsular extension (ECE) (HR 3.7), and Bloom-Richardson grade III (HR 3.1). The 5-year LRR rate was 3.4% (95% confidence interval [CI], 0.1%-6.8%] for patients with 0-1 risk factor vs 14.6% [95% CI, 8.4%-20.9%] for patients with {>=}2 risk factors (P=.0006), respectively. On multivariate analysis, ECE (HR 4.3, P=.0006) and grade III (HR 3.6, P=.004) remained significant risk factors for LRR. The 5-year LRR was 4.1% in patients with neither grade III nor ECE, 8.1% with either grade III or ECE, and 50.4% in patients with both grade III and ECE (P<.0001); the corresponding 5-year distant metastasis-free survival rates were 91.8%, 85.4%, and 59.1% (P=.0004), respectively. Conclusions: PMRT offers excellent control for patients with 1-3 LN+, with no locoregional failures to date. Patients with 1-3 LN+ who have grade III disease and/or ECE should be strongly considered for PMRT.« less

33 CFR 110.67 - Delaware River, Essington, Pa.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

33 CFR 110.67 - Delaware River, Essington, Pa.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

33 CFR 110.67 - Delaware River, Essington, Pa.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

33 CFR 110.67 - Delaware River, Essington, Pa.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

33 CFR 110.67 - Delaware River, Essington, Pa.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

Administrator Succession Planning

ERIC Educational Resources Information Center

Wilson, Jackie

2009-01-01

The Delaware Department of Education, in collaboration with the Delaware Academy for School Leadership at the University of Delaware, has been the recipient of Wallace Foundation funding since 2000 as part of the foundation's initiative to develop and share ideas for strengthening education leadership. The grant has enabled the state education…

36. BOILER HOUSE, GENERAL VIEW LOOKING TOWARD COAL CAR No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

36. BOILER HOUSE, GENERAL VIEW LOOKING TOWARD COAL CAR No. 6 (NOTE: COAL DISTRIBUTER HOPPER & CONVEYOR THAT RUNS NORTH TO SOUTH BETWEEN TRACKS ON EAST TOWER SIDE) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

Applications of remote-sensing technology to environmental problems of Delaware and Delaware Bay

NASA Technical Reports Server (NTRS)

Bartlett, D.; Klemas, V.; Philpot, W.; Rogers, R.

1975-01-01

Digital processing of multispectral LANDSAT data was used to develop a computerized model for predicting oil slick movement within the Delaware Bay. LANDSAT imagery was also used to monitor offshore waste disposal sites for mapping of wetlands, and charting of tidal currents.

77 FR 71667 - Delaware Disaster #DE-00014

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-03

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13391 and 13392] Delaware Disaster DE-00014 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Delaware (FEMA- 4090-DR), dated 11...

75 FR 18245 - Delaware Disaster # DE-00007

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12104 and 12105] Delaware Disaster DE-00007 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Delaware (FEMA- 1896-DR), dated 03...

An Image Morphing Technique Based on Optimal Mass Preserving Mapping

DTIC Science & Technology

2007-06-01

Yan Yang, Steven Haker , and Allen Tannenbaum Abstract—Image morphing, or image interpolation in the time domain, deals with the metamorphosis of one...of Technology, Atlanta, GA 30332 USA (e-mail: zlzl@ece.gatech.edu; zhulei1976@hotmail.com; yan.yang@gatech.edu; tannenba@ece.gatech.edu). S. Haker is...with the Surgical Planning Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115 USA (e-mail: haker @bwh.harvard.edu

A Prospective Multi-center Trial of Escherichia coli Extract for the Prophylactic Treatment of Patients with Chronically Recurrent Cystitis

PubMed Central

Kim, Kun Suk; Kim, Ji-Yoon; Jeong, In Gab; Paick, Jae-Seung; Son, Hwancheol; Lim, Dae Jung; Shim, Hong Bang; Park, Won Hee; Jung, Hee Chang

2010-01-01

We have assessed the efficacy and safety of Escherichia coli extract (ECE; Uro-Vaxom®) which contains active immunostimulating fractions, in the prophylactic treatment of chronically recurrent cystitis. Forty-two patients with more than 2 episodes of cystitis in the proceeding 6 months were treated for 3 months with one capsule daily of ECE and observed for a further 6 months. The primary efficacy criterion was the number of episodes of recurrent cystitis during the 6 months after treatment compared to those during the 6 months before treatment. At the end of the 9-month trial, 34 patients (all women) were eligible for statistical analysis. Their mean age was 56.4 yr (range, 34-75 yr), and they had experienced recurrent urinary tract infections for 7.2±5.2 yr. The number of recurrences was significantly lower during the 6-month follow-up period than during the 6 months preceding the trial (0.35 vs. 4.26, P<0.001). During the follow-up, 28 (82.4%) patients had no recurrences and 4 (11.8%) had 1 each. In patients who relapsed, ECE alleviated cystitis symptoms, including painful voiding, frequency and urgency. There were no serious adverse events related to the study drug. Our study demonstrates the efficacy and safety of ECE in the prophylactic treatment of chronically recurrent cystitis. PMID:20191044

External Validation of the Updated Partin Tables in a Cohort of French and Italian Men

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhojani, Naeem; Department of Urology, University of Montreal, Montreal, PQ; Salomon, Laurent

2009-02-01

Purpose: To test the discrimination and calibration properties of the newly developed 2007 Partin Tables in two European cohorts with localized prostate cancer. Methods: Data on clinical and pathologic characteristics were obtained for 1,064 men treated with radical prostatectomy at the Creteil University Health Center in France (n = 839) and at the Milan University Vita-Salute in Italy (n = 225). Overall discrimination was assessed with receiver operating characteristic curve analysis, which quantified the accuracy of stage predictions for each center. Calibration plots graphically explored the relationship between predicted and observed rates of extracapsular extension (ECE), seminal vesicle invasion (SVI)more » and lymph node invasion (LNI). Results: The rates of ECE, SVI, and LNI were 28%, 14%, and 2% in the Creteil cohort vs. 11%, 5%, and 5% in the Milan cohort. In the Creteil cohort, the accuracy of ECE, SVI, and LNI prediction was 61%, 71%, and 82% vs. 66%, 92% and 75% for the Milan cohort. Important departures were recorded between Partin Tables' predicted and observed rates of ECE, SVI, and LNI within both cohorts. Conclusions: The 2007 Partin Tables demonstrated worse performance in European men than they originally did in North American men. This indicates that predictive models need to be externally validated before their implementation into clinical practice.« less

Detection of bluetongue virus in the blood of inoculated calves: comparison of virus isolation, PCR assay, and in vitro feeding of Culicoides variipennis.

PubMed

MacLachlan, N J; Nunamaker, R A; Katz, J B; Sawyer, M M; Akita, G Y; Osburn, B I; Tabachnick, W J

1994-01-01

The interval after infection when bluetongue virus (BTV) was present in the blood of calves inoculated with BTV serotype 10 (BTV 10) was evaluated by virus isolation (VI) in embryonated chicken eggs (ECE), BTV-specific polymerase chain reaction (PCR), and in vitro blood feeding of vector Culicoides variipennis (C.v.) sonorensis. BTV nucleic acid was detected by PCR in blood cells for 16 to 20 weeks after infection whereas infectious virus was detected by VI in ECE for 2 to 8 weeks. BTV was detected in calf blood by in vitro feeding of C.v. sonorensis for only 0 to 2 weeks after inoculation of calves with BTV 10. Selected bloods which were positive by PCR analysis but not by VI in ECE were not infectious for sheep. The data are consistent with the hypothesis that prolonged viremia in BTV-infected cattle results from association of the virus with blood cells, especially erythrocytes. The fact that calf blood that contained viral nucleic acid as determined by PCR analysis, but not infectious virus as determined by VI in ECE, was not infectious for either the insect vector or sheep suggests that cattle whose blood contains BTV nucleic acid but not infectious virus are unimportant to the epidemiology of BTV infection.

Electroclinic effect in the chiral lamellar α phase of a lyotropic liquid crystal

NASA Astrophysics Data System (ADS)

Harjung, Marc D.; Giesselmann, Frank

2018-03-01

In thermotropic chiral Sm -A* phases, an electric field along the smectic layers breaks the D∞ symmetry of the Sm -A* phase and induces a tilt of the liquid crystal director. This so-called electroclinic effect (ECE) was first reported by Garoff and Meyer in 1977 and attracted substantial scientific and technological interest due to its linear and submicrosecond electro-optic response [S. Garoff and R. B. Meyer, Phys. Rev. A 19, 338 (1979), 10.1103/PhysRevA.19.338]. We now report the observation of an ECE in the pretransitional regime from a lyotropic chiral lamellar Lα* phase into a lyo-Sm -C* phase, the lyotropic analog to the thermotropic Sm -C* phase which was recently discovered by Bruckner et al. [Angew. Chem. Int. Ed. 52, 8934 (2013), 10.1002/anie.201303344]. We further show that the observed ECE has all signatures of its thermotropic counterpart, namely (i) the effect is chiral in nature and vanishes in the racemic Lα phase, (ii) the effect is essentially linear in the sign and magnitude of the electric field, and (iii) the magnitude of the effect diverges hyperbolically as the temperature approaches the critical temperature of the second order tilting transition. Specific deviations between the ECEs in chiral lamellar and chiral smectic phases are related to the internal field screening effect of electric double layers formed by inevitable ionic impurities in lyotropic phases.

Detailed Performance Assessment for the ITER ECE Diagnostic

NASA Astrophysics Data System (ADS)

Rowan, W.; Austin, M.; Houshmandyar, S.; Phillips, P.; Beno, J.; Bryant, A.; Ouroua, A.; Weeks, D.; Hubbard, A.; Taylor, G.

2017-10-01

One of the primary diagnostics for electron temperature (Te) measurement on ITER is based on the detection of electron cyclotron emission (ECE) Here we describe the predicted performance of the newly completed ECE diagnostic design by quantitatively following the emission from the plasma to the instruments and including the calibration method to assess accuracy. Operation of the diagnostic at 5.3 T is the main interest here but critical features of the emission spectra for 2.65 T and 1.8 T will be described. ECE will be collected by two very similar optical systems: one a radial view, the other an oblique view. Both measurements are used for Te while the oblique view also allows detection of non-thermal distortion in the electron distribution. An in-vacuum calibration source is included in the front end of each view to calibrate out the effect of any degradation of in-vessel optics. Following collection, the emission is split into orthogonal polarizations and transmitted to the detection instruments via waveguides filled with dry nitrogen, a choice that simplifies construction and analysis. Near the instruments, a switchyard is used to select which polarization and view is detected by each instrument. The design for the radiometer used for 5.3 T will be described in detail. Supported by PPPL/US-DA via subcontract S013464-H to UT Austin.

Transfer of Timing Information from RGC to LGN Spike Trains

NASA Astrophysics Data System (ADS)

Teich, Malvin C.; Lowen, Steven B.; Saleh, Bahaa E. A.; Kaplan, Ehud

1998-03-01

We have studied the firing patterns of retinal ganglion cells (RGCs) and their target lateral geniculate nucleus (LGN) cells. We find that clusters of spikes in the RGC neural firing pattern appear at the LGN output essentially unchanged, while isolated RGC firing events are more likely to be eliminated; thus the LGN action-potential sequence is therefore not merely a randomly deleted version of the RGC spike train. Employing information-theoretic techniques we developed for point processes,(B. E. A. Saleh and M. C. Teich, Phys. Rev. Lett.) 58, 2656--2659 (1987). we are able to estimate the information efficiency of the LGN neuronal output --- the proportion of the variation in the LGN firing pattern that carries information about its associated RGC input. A suitably modified integrate-and-fire neural model reproduces both the enhanced clustering in the LGN data (which accounts for the increased coefficient of variation) and the measured value of information efficiency, as well as mimicking the results of other observed statistical measures. Reliable information transmission therefore coexists with fractal fluctuations, which appear in RGC and LGN firing patterns.(M. C. Teich, C. Heneghan, S. B. Lowen, T. Ozaki, and E. Kaplan, J. Opt. Soc. Am. A) 14, 529--546 (1997).

77 FR 45527 - Approval and Promulgation of Air Quality Implementation Plans; Delaware; Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... to Delaware's Prevention of Significant Deterioration (PSD) and nonattainment New Source Review (NSR... infrastructure requirements of the Clean Air Act (CAA) which relate to Delaware's PSD permitting program and are.... www.regulations.gov . Follow the on-line instructions for submitting comments. B. Email: cox.kathleen...

Delaware | Solar Research | NREL

Science.gov Websites

. Customer-generators interested in selling Solar Renewable Energy Credits (SRECs) into the Delaware spot periods starting on April 1st or October 1st as chosen by the customer. Net Metering Delaware modified the state net metering significantly in 2017, including expanding it to all customer classes, adding biogas

75 FR 12561 - Delaware River and Bay Oil Spill Advisory Committee; Meeting Cancelled

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-16

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2008-0333] Delaware River and Bay Oil Spill Advisory Committee; Meeting Cancelled AGENCY: Coast Guard, DHS. ACTION: Notice of cancellation of meeting. SUMMARY: The Delaware River and Bay Oil Spill Advisory Committee (DRBOSAC) meeting scheduled for...

25. BOILER HOUSE, LOOKING FROM THE NORTHEAST AT COAL CARS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. BOILER HOUSE, LOOKING FROM THE NORTHEAST AT COAL CARS No. 9 & 5 (NOTE: COAL CONVEYOR RUNNING ABOVE THE CARS; THIS CONVEYOR ORIGINATES IN COAL TOWER No. 1 (WEST)) - Delaware County Electric Company, Chester Station, Delaware River at South end of Ward Street, Chester, Delaware County, PA

USING EMERGY TO QUANTIFY AN ECONOMIC HIERACHY BETWEEN FOUR U.S. STATES-MARYLAND, DELAWARE, NEW JERSEY, AND PENNSYLVANIA

EPA Science Inventory

Using emergy to quantify an economic hierarchy between four U.S. states - Maryland, Delaware, New Jersey and Pennsylvania
A regional emergy evaluation was completed for each of four adjacent states with differing levels and sources of economic productivity ? Maryland, Delaware...

Delaware Middle Schools Beating the Odds. Technical Report Number T2010.4

ERIC Educational Resources Information Center

Grusenmeyer, Linda; Fifield, Steve; Murphy, Aideen; Nian, Qinghua; Qian, Xiaoyu

2010-01-01

The investigation identified Delaware public and charter middle schools across the state which outperformed other Delaware middle schools with similar student demographic profiles. Teachers and administrators at six of these "Beating the Odds" schools and at six comparison middle schools were surveyed regarding their schools…

Use of the Environment and Policy Evaluation and Observation as a Self-Report Instrument (EPAO-SR) to measure nutrition and physical activity environments in child care settings: validity and reliability evidence.

PubMed

Ward, Dianne S; Mazzucca, Stephanie; McWilliams, Christina; Hales, Derek

2015-09-26

Early care and education (ECE) centers are important settings influencing young children's diet and physical activity (PA) behaviors. To better understand their impact on diet and PA behaviors as well as to evaluate public health programs aimed at ECE settings, we developed and tested the Environment and Policy Assessment and Observation - Self-Report (EPAO-SR), a self-administered version of the previously validated, researcher-administered EPAO. Development of the EPAO-SR instrument included modification of items from the EPAO, community advisory group and expert review, and cognitive interviews with center directors and classroom teachers. Reliability and validity data were collected across 4 days in 3-5 year old classrooms in 50 ECE centers in North Carolina. Center teachers and directors completed relevant portions of the EPAO-SR on multiple days according to a standardized protocol, and trained data collectors completed the EPAO for 4 days in the centers. Reliability and validity statistics calculated included percent agreement, kappa, correlation coefficients, coefficients of variation, deviations, mean differences, and intraclass correlation coefficients (ICC), depending on the response option of the item. Data demonstrated a range of reliability and validity evidence for the EPAO-SR instrument. Reporting from directors and classroom teachers was consistent and similar to the observational data. Items that produced strongest reliability and validity estimates included beverages served, outside time, and physical activity equipment, while items such as whole grains served and amount of teacher-led PA had lower reliability (observation and self-report) and validity estimates. To overcome lower reliability and validity estimates, some items need administration on multiple days. This study demonstrated appropriate reliability and validity evidence for use of the EPAO-SR in the field. The self-administered EPAO-SR is an advancement of the measurement of ECE settings and can be used by researchers and practitioners to assess the nutrition and physical activity environments of ECE settings.

Can animal habitat use patterns influence their vulnerability to extreme climate events? An estuarine sportfish case study.

PubMed

Boucek, Ross E; Heithaus, Michael R; Santos, Rolando; Stevens, Philip; Rehage, Jennifer S

2017-10-01

Global climate forecasts predict changes in the frequency and intensity of extreme climate events (ECEs). The capacity for specific habitat patches within a landscape to modulate stressors from extreme climate events, and animal distribution throughout habitat matrices during events, could influence the degree of population level effects following the passage of ECEs. Here, we ask (i) does the intensity of stressors of an ECE vary across a landscape? And (ii) Do habitat use patterns of a mobile species influence their vulnerability to ECEs? Specifically, we measured how extreme cold spells might interact with temporal variability in habitat use to affect populations of a tropical, estuarine-dependent large-bodied fish Common Snook, within Everglades National Park estuaries (FL US). We examined temperature variation across the estuary during cold disturbances with different degrees of severity, including an extreme cold spell. Second, we quantified Snook distribution patterns when the passage of ECEs is most likely to occur from 2012 to 2016 using passive acoustic tracking. Our results revealed spatial heterogeneity in the intensity of temperature declines during cold disturbances, with some habitats being consistently 3-5°C colder than others. Surprisingly, Snook distributions during periods of greatest risk to experience an extreme cold event varied among years. During the winters of 2013-2014 and 2014-2015 a greater proportion of Snook occurred in the colder habitats, while the winters of 2012-2013 and 2015-2016 featured more Snook observed in the warmest habitats. This study shows that Snook habitat use patterns could influence vulnerability to extreme cold events, however, whether Snook habitat use increases or decreases their vulnerability to disturbance depends on the year, creating temporally dynamic vulnerability. Faunal global change research should address the spatially explicit nature of extreme climate events and animal habitat use patterns to identify potential mechanisms that may influence population effects following these disturbances. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

Examination of contaminant exposure and reproduction of ospreys (Pandion haliaetus) nesting in Delaware Bay and River in 2015.

PubMed

Rattner, Barnett A; Lazarus, Rebecca S; Bean, Thomas G; McGowan, Peter C; Callahan, Carl R; Erickson, Richard A; Hale, Robert C

2018-05-22

A study of ospreys (Pandion haliaetus) nesting in the coastal Inland Bays of Delaware, and the Delaware Bay and Delaware River in 2015 examined spatial and temporal trends in contaminant exposure, food web transfer and reproduction. Concentrations of organochlorine pesticides and metabolites, polychlorinated biphenyls (PCBs), coplanar PCB toxic equivalents, polybrominated diphenyl ethers (PBDEs) and other flame retardants in sample eggs were generally greatest in the Delaware River. Concentrations of legacy contaminants in 2015 Delaware Bay eggs were lower than values observed in the 1970s through early 2000s. Several alternative brominated flame retardants were rarely detected, with only TBPH [bis(2-ethylhexyl)-tetrabromophthalate)] present in 5 of 27 samples at <5 ng/g wet weight. No relation was found between p,p'-DDE, total PCBs or total PBDEs in eggs with egg hatching, eggs lost from nests, nestling loss, fledging and nest success. Osprey eggshell thickness recovered to pre-DDT era values, and productivity was adequate to sustain a stable population. Prey fish contaminant concentrations were generally less than those in osprey eggs, with detection frequencies and concentrations greatest in white perch (Morone americana) from Delaware River compared to the Bay. Biomagnification factors from fish to eggs for p,p'-DDE and total PCBs were generally similar to findings from several Chesapeake Bay tributaries. Overall, findings suggest that there have been improvements in Delaware Estuary waterbird habitat compared to the second half of the 20th century. This trend is in part associated with mitigation of some anthropogenic contaminant threats. Copyright © 2018 Elsevier B.V. All rights reserved.

Dynamic Undergraduate Climate Change Affinity Program: University of Delaware Climate Program for Undergraduates (CPUG)

NASA Astrophysics Data System (ADS)

Merrill, J.

2017-12-01

Multidisciplinary undergraduate climate change education is critical for students entering any sector of the workforce. The University of Delaware has developed a new interdisciplinary affinity program—UD Climate Program for Undergraduates (CPUG)—open to undergraduate students of all majors to provide a comprehensive educational experience designed to educate skilled climate change problem-solvers for a wide range of professional careers. The program is designed to fulfill all General Education requirements, and includes a residential community commitment and experiential learning in community outreach and problem solving. Seminars will introduce current popular press and research materials and provide practice in confirming source credibility, communications training, and psychological support, as well as team building. As undergraduates, members of the UD CPUG team will define, describe, and develop a solution or solutions for a pressing local climate challenge that has the potential for global impact. The choice of a challenge and approach to addressing it will be guided by the student's advisor. Students are expected to develop a practical, multidisciplinary solution to address the challenge as defined, using their educational and experiential training. Solutions will be presented to the UD community during the spring semester of their senior year, as a collaborative team solution, with enhancement through individual portfolios from each team member. The logic model, structure, curricular and co-curricular supports for the CPUG will be provided. Mechanisms of support available through University administration will also be discussed.

Channel microband electrode arrays for mechanistic electrochemistry. Two-dimensional voltammetry:  transport-limited currents.

PubMed

Alden, J A; Feldman, M A; Hill, E; Prieto, F; Oyama, M; Coles, B A; Compton, R G; Dobson, P J; Leigh, P A

1998-05-01

A channel electrode array, with electrodes ranging in size from the millimeter to the submicrometer scale, is used for the amperometric interrogation of mechanistically complex electrode processes. In this way, the transport-limited current, measured as a function of both electrode size and electrolyte flow rate (convection), is shown to provide a highly sensitive probe of mechanism and kinetics. The application of "two-dimensional voltammetry" to diverse electrode processes, including E, ECE, ECEE, EC', and DISP2 reactions, is reported.

Stepping Up Together: Financing Early Care and Education in the 21st Century. Volume 2. Proceedings for "Making It Economically Viable: Financing Early Care and Education." A Working Meeting (Santa Cruz, California, March 3-5, 1999).

ERIC Educational Resources Information Center

National Association of Child Advocates, Washington, DC.

The need for an adequate financial base for the future of quality early care and education (ECE) for young children is being increasingly recognized. This document presents the proceedings for a 1999 working meeting of individuals from diverse fields to identify and explore possible actions related to financing ECE for children birth through 5…

Literacy at the Core of the Delaware World Language Immersion Programs

ERIC Educational Resources Information Center

Fulton-Archer, Lynn

2013-01-01

Certain aspects of the implementation of language immersion programs in Delaware are unique given the state's size, demographics, and role in national education initiatives including Race to the Top, Common Core, and Smarter Balance. The Delaware experience typifies what every state, district, or even school goes through as they try to provide…

Delaware's Rural Assistance Council Promotes the Rural Agenda in the First State.

ERIC Educational Resources Information Center

VanSciver, James H.

The Delaware Research for Better Schools Rural Assistance Council's (RAC) mission is to develop a rural assistance agenda for the state. The Council stated four objectives: (1) identifying the most pressing needs of Delaware's rural schools and school districts; (2) developing plans, in cooperation with appropriate state organizations, for…

76 FR 42557 - Approval and Promulgation of Air Quality Implementation Plans; Delaware; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

... Promulgation of Air Quality Implementation Plans; Delaware; Regional Haze State Implementation Plan AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is approving the Delaware Regional Haze... visibility in mandatory Class I areas through a regional haze program. EPA is also approving this revision...

77 FR 44232 - Delegation of Authority To Implement and Enforce Outer Continental Shelf Air Regulations to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-27

... Outer Continental Shelf Air Regulations to the Delaware Department of Natural Resources and.... SUMMARY: On July 21, 2010, EPA sent the Delaware Department of Natural Resources and Environmental Control... of Natural Resources and Environmental Control, 89 Kings Highway, P.O. Box 1401, Dover, Delaware. FOR...

Kids Count in Delaware, Families Count in Delaware: Fact Book, 2003.

ERIC Educational Resources Information Center

Delaware Univ., Newark. Kids Count in Delaware.

This Kids Count Fact Book is combined with the Families Count Fact Book to provide information on statewide trends affecting children and families in Delaware. The Kids Count and Families Count indicators have been combined into four new categories: health and health behaviors, educational involvement and achievement, family environment and…

University of Delaware Demonstrated at NREL Vehicle-to-Grid Characteristics

Science.gov Websites

University of Delaware Demonstrated at NREL Vehicle-to-Grid Characteristics of Electric Vehicles At the Energy Systems Integration Facility (ESIF), the University of Delaware demonstrated the vehicle-to-grid , featuring vehilce-to-grid integration capabilities enabling it to feed power back to the grid and

Delaware Education State Report Card, 2005-2006

ERIC Educational Resources Information Center

Delaware Department of Education, 2007

2007-01-01

This report, submitted to the U.S. Department of Education, contains summary details of Delaware students' growth in the areas of reading, mathematics, writing, science and social studies. The results reported herein are part of a long-term effort to gather data on Delaware students' educational progress and use the data to inform decisions about…

Shared Decision Making in Education Governance Using Business Portals

ERIC Educational Resources Information Center

Peoples, Adrian L.

2009-01-01

The purpose of this study was to address a high-volume problem for the Delaware Department of Education Office of Professional Accountability (OPA). This problem was addressed by sharing the certification decision with qualified personnel located at each of the four teacher preparation programs located in Delaware at Delaware State University…

Delaware Consortium for Undergraduate Minority Training in Prostate Cancer

DTIC Science & Technology

2008-02-01

Nanoparticle Hyperthermia Induced Wound-Healing Assay in Prostate Cancer Cells. Adaire T. Heady, Michael J. Bonder, Ph.D., David J. DeGraff, M.S., Robert...6 Development of Magnetic Nanoparticle Hyperthermia ...George C. Hadjipanayis, Ph.D., Delaware State University, Dover, DE, USA, University of Delaware, Neware, DE, USA The use of magnetic nanoparticle

The Delaware Revitalization Movement of the Early 1760s: A Suggested Reinterpretation.

ERIC Educational Resources Information Center

Champagne, Duane

1988-01-01

Argues that the Delaware Indian revitalization movement was a response to the threatening British hegemonic political and trade situation after the French defeat in 1759. Examines the new moral order proclaimed by the Delaware prophets and the movement's primary goals of political and economic independence. Contains 47 references. (SV)

A predictive model for anti-degradation monitoring of the Delaware River mainstem

EPA Science Inventory

The non-tidal portion of the Delaware River can be considered to be in minimally disturbed condition, but there is increasing pressure on the watershed. Thus, the primary goal of this research was to develop a monitoring tool that can be used by the Delaware River Basin Commissi...

77 FR 60053 - Approval and Promulgation of Air Quality Implementation Plans; Delaware; Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-02

... Deterioration and Nonattainment New Source Review; Fine Particulate Matter (PM2.5) AGENCY: Environmental... preconstruction permitting requirements for fine particulate matter (PM 2.5 ) into the Delaware SIP. In addition... fine particulate matter (PM 2.5 ) into the Delaware SIP. In addition, EPA proposed approval of SIP...

State Education Finance and Governance Profile: Delaware

ERIC Educational Resources Information Center

Canon, Katherine

2010-01-01

This article presents the state education finance and governance of Delaware. Funding for public education generally comes from three sources: the federal government (7.6%), the state government (64.3%), and local governments (28.1%). Educational expenditures for K-12 public schools in Delaware total $1.66 billion. Per-pupil expenditure in the…

New School of Management, Delaware State University, Dover, Delaware.

ERIC Educational Resources Information Center

Design Cost Data, 2001

2001-01-01

Presents features of Delaware State University's New School of Management designed to stimulate positive gains in teaching and learning. The design incorporates state of the art distance learning systems that includes a 350-seat auditorium possessing the same capability, and a commercial kitchen and dining facility for chef and hotel management…

Comparative status and assessment of Limulus polyphemus with emphasis on the New England and Delaware Bay populations

USGS Publications Warehouse

Smith, David; Millard, Michael J.; Carmichael, Ruth H.

2009-01-01

Increases in harvest of the American horseshoe crab (Limulus polyphemus) during the 1990s, particularly for whelk bait, coupled with decreases in species that depend on their eggs has reduced horseshoe crab abundance, threatened their ecological relationships, and dictated precautionary management of the horseshoe crab resource. Accordingly, population assessments and monitoring programs have been developed throughout much of the horseshoe crab’s range. We review and discuss implications for several recent assessments of Delaware Bay and New England populations and a meta-analysis of region-specific trends. These assessments show that the western Atlantic distribution of the horseshoe crab is comprised of regional or estuarine-specific meta-populations, which exhibit distinct population dynamics and require management as separate units. Modeling of Delaware Bay and Cape Cod populations confirmed that overharvest caused declines, but indicated that some harvest levels are sustainable and consistent with population growth. Coast-wide harvest was reduced by 70% from 1998 to 2006, with the greatest reductions within Delaware Bay states. Harvest regulations in Delaware Bay starting in the late 1990s, such as harvest quotas, seasonal closures, male-only harvest, voluntary use of bait-saving devices, and establishment of the Carl N. Shuster Jr. Horseshoe Crab Reserve, were followed by stabilization and recent evidence of increase in abundance of horseshoe crabs in the region. However, decreased harvest of the Delaware Bay population has redirected harvest to outlying populations, particularly in New York and New England. While the recent Delaware Bay assessments indicate positive population growth, increased harvest elsewhere is believed to be unsustainable. Two important considerations for future assessments include (1) managing Delaware Bay horseshoe crab populations within a multi-species context, for example, to help support migratory shorebirds and (2) anticipating the potential for harvest restrictions within Delaware Bay to redirect harvest onto outlying populations that cannot sustain the increased harvest.

A decision support framework for water management in the Upper Delaware River

USGS Publications Warehouse

Bovee, Ken D.; Waddle, Terry J.; Bartholow, John; Burris, Lucy

2007-01-01

The Delaware River Basin occupies an area of 12,765 square miles, in portions of south central New York, northeast Pennsylvania, northeast Delaware, and western New Jersey (fig. 1). The river begins as two streams in the Catskill Mountains, the East and West Branches. The two tributaries flow in a southwesterly direction until they meet at Hancock, N.Y. The length of the river from the mouth of Delaware Bay to the confluence at Hancock is 331 miles. Approximately 200 miles of the river between Hancock, N.Y., and Trenton, N.J., is nontidal.

Report of the River Master of the Delaware River for the period December 1, 2008–November 30, 2009

USGS Publications Warehouse

Krejmas, Bruce E.; Paulachok, Gary N.; Mason, Jr., Robert R.; Owens, Marie

2016-04-06

A Decree of the Supreme Court of the United States, entered June 7, 1954, established the position of Delaware River Master within the U.S. Geological Survey (USGS). In addition, the Decree authorizes diversions of water from the Delaware River Basin and requires compensating releases from certain reservoirs, owned by New York City, to be made under the supervision and direction of the River Master. The Decree stipulates that the River Master will furnish reports to the Court, not less frequently than annually. This report is the 56th Annual Report of the River Master of the Delaware River. It covers the 2009 River Master report year, the period from December 1, 2008, to November 30, 2009.During the report year, precipitation in the upper Delaware River Basin was 50.89 inches (in.) or 116 percent of the long-term average. Combined storage in Pepacton, Cannonsville, and Neversink Reservoirs remained high throughout the year and did not decline below 80 percent of combined capacity at any time. Delaware River operations during the year were conducted as stipulated by the Decree and the Flexible Flow Management Program (FFMP).Diversions from the Delaware River Basin by New York City and New Jersey were in full compliance with the Decree. Reservoir releases were made as directed by the River Master at rates designed to meet the flow objective for the Delaware River at Montague, New Jersey, on 25 days during the report year. Releases were made at conservation rates—rates designed to relieve thermal stress and protect the fishery and aquatic habitat in the tailwaters of the reservoirs—on all other days.During the report year, New York City and New Jersey complied fully with the terms of the Decree, and directives and requests of the River Master.As part of a long-term program, the quality of water in the Delaware Estuary between Trenton, New Jersey, and Reedy Island Jetty, Delaware, was monitored at various locations. Data on water temperature, specific conductance, dissolved oxygen, and pH were collected continuously by electronic instruments at four sites. In addition, selected water-quality data were collected at 22 sites on a monthly basis.The Delaware River Basin Commission (DRBC) collects monthly samples from March through October at 22 sites between Biles Channel and South Brown Shoal. Samples were collected and analyzed by the State of Delaware for the DRBC. At each site, water samples were collected at a single point near the center of the channel near the surface and analyzed for selected physical properties, and chemical and biological constituents including routine chemical substances, nutrients and bacteria. These consist of analyses of field measurements and laboratory determinations.

Introduction to the Delaware River Port Authority's Smart Bridges initiative

NASA Astrophysics Data System (ADS)

Box, Robert A.; McCullough, Patrick J.; Bistline, Robert S.

2000-06-01

The Delaware River Port Authority, whose mission is to manage, plan and construct transportation facilities and provide transportation services to maximize the safe and efficient movement of people and freight within the Delaware River Valley, located in southwestern Pennsylvania and southern New Jersey, is a self-financing, bi-state Authority, formed by a compact between the Commonwealth of Pennsylvania and the State of New Jersey and approved by the Congress of the United States. The Delaware River Port Authority is firmly committed to the strategic and integrated use of advanced transportation technology to improve traffic flow, operational efficiency and safety on DRPA's four bridges. To this end, the Delaware River Port Authority has initiated a program, appropriately named 'Smart Bridges.' The Delaware River Port Authority has recognized that this type of program is essential to the advancement of the DRPA's mission as an efficient, customer- friendly transportation and regional development agency. Under the Smart Bridges program the Delaware River Port Authority is introducing new technology into its aging infrastructure and transportation systems to ensure that the facilities continue to serve the region into the 21st century and beyond. Initiatives introduced under this program include EZ Pass, video surveillance systems, computerized traffic control systems and partnering with local universities to investigate the application of various innovative technologies to assist in the maintenance of the bridge facilities.

Understanding the bursty electron cyclotron emission during a sawtooth crash in the HT-7 tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Erzhong, E-mail: rzhonglee@ipp.ac.cn; Hu, Liqun; Chen, Kaiyun

2014-01-15

Bursts in electron cyclotron emission (ECE) were observed during sawtooth crashes in HT-7 in discharges with ion cyclotron resonance heating injected near the q = 1 rational surface (q is the safety factor). The local ECE measurement indicated that the bursty radiation is only observed on channels near but a little away outward from the q = 1 magnetic surface. In conjunction with the soft x-ray tomography analysis, it was determined that, for the first time, only a compression process survives in the later stage of fast magnetic reconnection but before prompt heat transport. The compression enhanced the electron radiation temperature, the increased amplitudemore » of which agreed well with the estimation according to a kinetic compression theory model [R. J. Hastie and T. C. Hender, Nucl. Fusion 28, 585 (1988)]. This paper presents the experimental evidence that there indeed exists a transient compression phase which results in the bursty ECE radiation during a sawtooth crash.« less

Effect of ultrasound on electrochemical chloride extraction from mortar

NASA Astrophysics Data System (ADS)

Chen, Yiqun; Yao, Wu; Zuo, Junqing

2018-03-01

In this paper, the effect of auxiliary ultrasound on electrochemical chloride extraction (ECE) was studied. The chloride removal efficiency was investigated by examining the chloride content with ultrasound-assisted ECE and changing the introducing time of ultrasound. The experimental results showed that removal of chloride ions was noted to be more effective in ECE treatment assisted with ultrasound treatment (UT). In addition, the lower w/c ratio led to more distinct effect of ultrasonic cavitation on chloride removal. Electrochemical behaviors measured with different treatment revealed that UT treatment was effective on moderating the corrosion condition. Microstructural analyses revealed a significant alteration in composition and morphology of cementitious phases with UT treatment. Pull-out tests indicated that ultrasound had a certain negative impact on the bond strength. Although the effect of introducing ultrasound in the first 2 weeks or the last 2 weeks on the extraction efficiency was not obvious, intermittent ultrasound could not only ensure the chloride extraction efficiency, but also reduce the adverse effect of ultrasound on the bond strength.

The timber industries of New Jersey and Delaware

Treesearch

James T. Bones

1973-01-01

Results of a field canvass of all known primary wood manufacturers that operated in Delaware and New Jersey in 1970. The industrial wood statistics are compared with previous surveys and important trends in industry development are noted. Total roundwood output was down 31 percent in Delaware since 1956 and down 43 percent in New Jersey since 1955.

33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

Code of Federal Regulations, 2013 CFR

2013-07-01

...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area: All waters of the Chesapeake and Delaware (C & D) Canal within the anchorage basin at Chesapeake City...

33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

Code of Federal Regulations, 2012 CFR

2012-07-01

...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area: All waters of the Chesapeake and Delaware (C & D) Canal within the anchorage basin at Chesapeake City...

33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

Code of Federal Regulations, 2014 CFR

2014-07-01

...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area: All waters of the Chesapeake and Delaware (C & D) Canal within the anchorage basin at Chesapeake City...

The Perceived Readiness of the Graduates of Delaware State University to Transition into the Workforce

ERIC Educational Resources Information Center

Scott-Cheatham, Lawita Germaine

2013-01-01

This study was designed to explore the perceived readiness of the graduating seniors at Delaware State University to transition from the classroom into the workforce. Delaware State University's undergraduate graduating class of 2012, 547 undergraduate seniors, were invited to participate in an online survey comprised of 23 items--derived from the…

Forests of Delaware, 2015

Treesearch

Tonya Lister; Richard Widmann

2016-01-01

This publication provides an overview of forest resources in Delaware based on inventories conducted by the U.S. Forest Service, Forest Inventory and Analysis (FIA) program of the Northern Research Station. From 2004-2013, FIA employed an annual inventory with a cycle length of 5 years, measuring data on 20 percent of all sample plots each year in Delaware. Beginning...

33 CFR 334.120 - Delaware Bay off Milford Neck; naval aircraft bombing target area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Delaware Bay off Milford Neck; naval aircraft bombing target area. 334.120 Section 334.120 Navigation and Navigable Waters CORPS OF....120 Delaware Bay off Milford Neck; naval aircraft bombing target area. (a) The danger zone. A circular...

33 CFR 334.120 - Delaware Bay off Milford Neck; naval aircraft bombing target area.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Delaware Bay off Milford Neck; naval aircraft bombing target area. 334.120 Section 334.120 Navigation and Navigable Waters CORPS OF....120 Delaware Bay off Milford Neck; naval aircraft bombing target area. (a) The danger zone. A circular...

The Delaware Geography-Health Initiative: Lessons Learned in Designing a GIS-Based Curriculum

ERIC Educational Resources Information Center

Rees, Peter W.; Silberman, Jordan A.

2010-01-01

The Delaware Geography-Health Initiative is a Web- and GIS-based set of lesson units for teaching geographic concepts and research methods within the context of the state's high school geography standards. Each unit follows a research-based, inquiry-centered model addressing questions of health because of Delaware's high incidence of cancer,…

Forests of Delaware, 2016

Treesearch

Stephen Potter

2017-01-01

This publication provides an overview of forest resources in Delaware based on inventories conducted by the U.S. Forest Service, Forest Inventory and Analysis (FIA) program of the Northern Research Station. From 2004-2013, FIA employed an annual inventory with a cycle length of 5 years, measuring data on 20 percent of all sample plots each year in Delaware. Beginning...

33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

Code of Federal Regulations, 2011 CFR

2011-07-01

... River to Chesapeake Bay, Del. and Md., between Reedy Point, Delaware River, and Old Town Point Wharf.... Traffic lights are located at Reedy Point and Old Town Point Wharf. These traffic lights are described in..., jetties, piers, fences, buildings, trees, telephone lines, lighting structures, or any other property of...

The forest-land owners of Delaware

Treesearch

Neal P. Kingsley; James C. Finley

1975-01-01

A statistical-analytical report on a mail canvass of the owners of privately owned forest land in Delaware, based on a study made in conjunction with the second forest survey of Delaware by the USDA Forest Service. Statistical findings are based on responses supplied by owners to a questionnaire. Trends in forest-land ownership and the attitudes and intentions of...

From the Boardroom to the Blackboard. The Business Role in Improving Education in Delaware. Successful Strategies Series.

ERIC Educational Resources Information Center

National Alliance of Business, Inc., Washington, DC.

Business leadership is playing a vital role in the success of New Directions, Delaware's comprehensive effort to improve its education system. Through New Directions, business leaders are supporting higher academic achievement for all Delaware students. Four curriculum frameworks commissions, each of which is co-chaired by a practicing Delaware…

33 CFR 165.510 - Delaware Bay and River, Salem River, Christina River and Schuylkill River-Regulated Navigation Area.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Delaware Bay and River, Salem River, Christina River and Schuylkill River-Regulated Navigation Area. 165.510 Section 165.510... Limited Access Areas Fifth Coast Guard District § 165.510 Delaware Bay and River, Salem River, Christina...

33 CFR 165.510 - Delaware Bay and River, Salem River, Christina River and Schuylkill River-Regulated Navigation Area.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Delaware Bay and River, Salem River, Christina River and Schuylkill River-Regulated Navigation Area. 165.510 Section 165.510... Limited Access Areas Fifth Coast Guard District § 165.510 Delaware Bay and River, Salem River, Christina...

Race to the Top. Delaware Report. Year 1: School Year 2010-2011. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2012

2012-01-01

This State-specific summary report serves as an assessment of Delaware's Year 1 Race to the Top implementation, highlighting successes and accomplishments, identifying challenges, and providing lessons learned from implementation to date. Delaware created new structures at the State level to support both State and LEA (local education agency) Race…

Forests of Delaware, 2014

Treesearch

T.W. Lister; R.H. Widmann

2015-01-01

This publication provides an overview of forest resources in Delaware based on inventories conducted by the U.S. Forest Service, Forest Inventory and Analysis (FIA) program of the Northern Research Station. From 2004-2013, FIA employed an annual inventory with a cycle length of 5 years, measuring data on 20 percent of all sample plots each year in Delaware. Beginning...

76 FR 11961 - Safety Zone, Dredging Operations; Delaware River, Marcus Hook, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-04

...-AA00 Safety Zone, Dredging Operations; Delaware River, Marcus Hook, PA AGENCY: Coast Guard, DHS. ACTION... Delaware River while the Dredge Pullen conducts dredging operations at the Sunoco Marcus Hook docks in the vicinity of the Marcus Hook Range near Marcus Hook, PA. This action is necessary to maintain the 42 ft...

Race to the Top. Delaware Report. Year 4: School Year 2013-2014. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2015

2015-01-01

The State-specific summary report serves as an assessment of Delaware's annual Race to the Top implementation. The Year 4 report for Phase 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2013 through September 2014. Given that Delaware and…

33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

Code of Federal Regulations, 2010 CFR

2010-07-01

...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area: All waters of the Chesapeake and Delaware (C & D) Canal within the anchorage basin at Chesapeake City...

33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

Code of Federal Regulations, 2011 CFR

2011-07-01

...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area: All waters of the Chesapeake and Delaware (C & D) Canal within the anchorage basin at Chesapeake City...

Race to the Top. Delaware Report. Year 3: School Year 2012-2013. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2014

2014-01-01

The State-specific summary report serves as an assessment of Delaware's annual Race to the Top implementation. The Year 3 report for Phase 1 and 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2012 through September 2013. Delaware made…

76 FR 4716 - Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Off Delaware, Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... No. BOEM-2010-0075] Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Off... commercial wind development on the OCS off Delaware and requests submission of indications of competitive... received two nominations of proposed lease areas: One from Bluewater Wind Delaware LLC (Bluewater) and...

A Collaborative Study of Disproportionate Chemical Risks in Seven Delaware Communities

NASA Astrophysics Data System (ADS)

Dryden, O.; Goldman, G. T.; White, R.; Moore, D.; Roberts, M.; Thomas, J.; Johnson, C.

2017-12-01

Studies have found that, compared to national averages, a significantly greater percentage of Blacks (African-Americans), Latinos (Hispanics), and people at or near poverty levels tend to live near industrial facilities that use large quantities of toxic chemicals and present a risk of major chemical disasters with potentially severe consequences for nearby communities. The Union of Concerned Scientists, the Environmental Justice Health Alliance for Chemical Policy Reform, and Delaware Concerned Residents for Environmental Justice collaborated on a study to examine the potential for cumulative impacts from health and safety risks for seven Delaware communities with a percentage of people of color and/or poverty levels greater than the Delaware average located along an industrial corridor in the northern portion of Delaware's New Castle County. These risks include close proximity to major industrial sources, as well as facilities that use large quantities of toxic, flammable or explosive chemicals and pose a high risk of a major chemical release or catastrophic incident. Additionally, proximity to contaminated waste sites was assessed, as well as the risk of cancer and potential for respiratory disease impacts from exposure to toxic air pollution. We found that people in these seven communities face a substantial cumulative health risk from exposure to toxic air pollution, proximity to polluting industrial facilities and hazardous chemical facilities, as well as contaminated waste sites. These health risks are substantially greater when compared to a wealthier and predominantly White Delaware community and for Delaware as a whole. Significant and expedited improvements in regulatory and public policy are needed at the national, state, and municipal levels to address the health and well-being of at-risk communities in Delaware and elsewhere.

Elastic Cherenkov effects in transversely isotropic soft materials-I: Theoretical analysis, simulations and inverse method

NASA Astrophysics Data System (ADS)

Li, Guo-Yang; Zheng, Yang; Liu, Yanlin; Destrade, Michel; Cao, Yanping

2016-11-01

A body force concentrated at a point and moving at a high speed can induce shear-wave Mach cones in dusty-plasma crystals or soft materials, as observed experimentally and named the elastic Cherenkov effect (ECE). The ECE in soft materials forms the basis of the supersonic shear imaging (SSI) technique, an ultrasound-based dynamic elastography method applied in clinics in recent years. Previous studies on the ECE in soft materials have focused on isotropic material models. In this paper, we investigate the existence and key features of the ECE in anisotropic soft media, by using both theoretical analysis and finite element (FE) simulations, and we apply the results to the non-invasive and non-destructive characterization of biological soft tissues. We also theoretically study the characteristics of the shear waves induced in a deformed hyperelastic anisotropic soft material by a source moving with high speed, considering that contact between the ultrasound probe and the soft tissue may lead to finite deformation. On the basis of our theoretical analysis and numerical simulations, we propose an inverse approach to infer both the anisotropic and hyperelastic parameters of incompressible transversely isotropic (TI) soft materials. Finally, we investigate the properties of the solutions to the inverse problem by deriving the condition numbers in analytical form and performing numerical experiments. In Part II of the paper, both ex vivo and in vivo experiments are conducted to demonstrate the applicability of the inverse method in practical use.

Edible gardens in early childhood education settings in Aotearoa, New Zealand.

PubMed

Dawson, A; Richards, R; Collins, C; Reeder, A I; Gray, A

2013-12-01

This paper aims to explore the presence and role of edible gardens in Aotearoa/New Zealand Early Childhood Education Services (ECES). Participant ECES providers were identified from the Ministry of Education database of Early Childhood Education Services (March 2009). These include Education and Care and Casual Education and Care, Kindergarten, Home-based Education and Care services, Playcentres, Te Kōhanga Reo. A structured, self-administered questionnaire was sent to the Principal or Head Teacher of the service. Of the 211 ECES that responded (55% response rate), 71% had edible gardens, incorporating vegetables, berry fruit, tree fruit, edible flowers and nut trees. Garden activities were linked with teaching across all strands of the New Zealand early childhood curriculum. In addition, 34% provided guidance on using garden produce and 30% linked the garden with messages on fruit and vegetable consumption. Most gardens were established recently (past 2 years) and relied on financial and non-financial support from parents, teachers and community organisations. Barriers included a lack of funding, space, time and staff support. Study findings suggest that gardens are already being used as a versatile teaching tool in many ECES settings. Most gardens are new, with a need to support the sustainability and workforce development among teachers and parents in order to be able to maintain these resources for future generations. SO WHAT?: Given the inherent links between gardening and healthy food and exercise, there seem to be extensive opportunities for health promotion aligned with the edible garden movement.

Neutral endopeptidase regulates neurogenic inflammatory responses induced by stimulation of human oral keratinocytes with bacterial lipopolysaccharide and nicotine.

PubMed

Nakata, Motoki; Awano, Shuji; Kinoshita, Naomasa; Yoshida, Akihiro; Ansai, Toshihiro

2013-10-01

Neutral endopeptidase (NEP) is present on various epithelial cells and inactivates numerous physiologically active peptides. Neutral endopeptidase may regulate proinflammatory signals in oral mucosal epithelium. However, the function of NEP in oral mucosal epithelium is unknown. The present study investigated the action of NEP upon proinflammatory signals on human oral keratinocytes and the influence of endothelin-converting enzyme (ECE)-1, an enzyme similar to NEP, on the functions of NEP. Oral keratinocytes were cultured in medium containing inflammatory inducers [lipopolysaccharide (LPS) and nicotine], NEP inhibitors, and ECE-1/NEP inhibitors, either alone or in combination. The concentrations of substance P (SP) and interleukin-1β (IL-1β) were measured in the supernatant. Additionally, the concentrations of SP and IL-1β were measured in the supernatant of cells incubated with LPS or nicotine after transfection with NEP small interfering RNA (siRNA). The concentrations of SP and IL-1β were significantly increased in cells incubated with NEP inhibitors and, to a lesser extent, in cells incubated with ECE-1/NEP inhibitors, compared with controls (cells incubated with LPS or nicotine alone). The concentrations of SP and IL-1β in cells transfected with NEP siRNA were significantly augmented compared with controls. In conclusion, the present study demonstrated that NEP down-regulated the levels of SP and IL-1β produced from human oral keratinocytes, although ECE-1 may be partly related to the down-regulation. © 2013 Eur J Oral Sci.

Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1.

PubMed

Law, Ivy Ka Man; Murphy, Jane E; Bakirtzi, Kyriaki; Bunnett, Nigel W; Pothoulakis, Charalabos

2012-04-27

The neuropeptide/hormone neurotensin (NT) mediates intestinal inflammation and cell proliferation by binding of its high affinity receptor, neurotensin receptor-1 (NTR1). NT stimulates IL-8 expression in NCM460 human colonic epithelial cells by both MAP kinase- and NF-κB-dependent pathways. Although the mechanism of NTR1 endocytosis has been studied, the relationship between NTR1 intracellular trafficking and inflammatory signaling remains to be elucidated. In the present study, we show that in NCM460 cells exposed to NT, β-arrestin-1 (βARR1), and β-arrestin-2 (βARR2) translocate to early endosomes together with NTR1. Endothelin-converting enzyme-1 (ECE-1) degrades NT in acidic conditions, and its activity is crucial for NTR1 recycling. Pretreatment of NCM460 cells with the ECE-1 inhibitor SM19712 or gene silencing of βARR1 or βARR2 inhibits NT-stimulated ERK1/2 and JNK phosphorylation, NF-κB p65 nuclear translocation and phosphorylation, and IL-8 secretion. Furthermore, NT-induced cell proliferation, but not IL-8 transcription, is attenuated by the JNK inhibitor, JNK(AII). Thus, NTR1 internalization and recycling in human colonic epithelial cells involves βARRs and ECE-1, respectively. Our results also indicate that βARRs and ECE-1-dependent recycling regulate MAP kinase and NF-κB signaling as well as cell proliferation in human colonocytes in response to NT.

Endovascular coil embolization of aneurysm neck for the treatment of ruptured intracranial aneurysm with bleb formation

PubMed Central

Wan, Jun; Gu, Weijin; Zhang, Xiaolong; Geng, Daoying; Lu, Gang; Huang, Lei; Zhang, Lei; Ge, Liang; Ji, Lihua

2014-01-01

Background Ruptured intracranial aneurysm (ICA) with bleb formation (RICABF) is a special type of ruptured ICA. However, the exact role and effectiveness of endovascular coil embolization (ECE) in RICABF is unknown. We aimed to investigate the effectiveness and safety of ECE of aneurysm neck for RICABF treatment. Material/Methods We retrospectively assessed consecutive patients who were hospitalized in our endovascular intervention center between October 2004 and May 2012. Overall, 86 patients underwent ECE of aneurysm neck for 86 RICABF. Treatments outcomes included secondary rupture/bleeding rate, aneurysm neck embolization rate, residual/recurrent aneurysm, intraoperative incidents, and post-embolization complications, as well as improvements in the Glasgow outcome scale (extended) (GOS-E). Results Complete occlusion was achieved in 72 aneurysms (72/86, 83.7%), while 12 aneurysms (12/86, 14.0%) had a residual neck, and 2 aneurysms (2/86, 2.3%) had a residual aneurysm. The postoperative GOS-E was 3 in 3 patients (3.5%), 4 in 10 patients (11.6%), and 5 in 73 patients (84.9%). Follow-up angiography was performed in all patients (mean 9.0 months, interquartile range of 9.0). Recurrence was found in 3 patients (3/86, 3.5%). No aneurysm rupture or bleeding was reported. Conclusions Our mid-term follow-up study showed that ECE of aneurysm neck was an effective and safe treatment modality for RICABF. The long-term effectiveness and safety of this interventional radiology technique need to be investigated in prospective and comparative studies. PMID:24986761

Comparing Apples to Oranges: An Evaluation of Quarter Calendar Data in the Delaware Study of Instructional Costs and Productivity

ERIC Educational Resources Information Center

Walters, Allison M.

2009-01-01

Four-year colleges and universities submit faculty teaching load and instructional cost data annually to the Delaware Study of Instructional Costs and Productivity. While the Delaware Study currently adjusts the calculation of annual FTE students to account for the difference in annual student credit hours (SCH) earned by students at semester and…

Feasibility of Rescheduled School Year Plans for Delaware Public Elementary and Secondary Schools.

ERIC Educational Resources Information Center

Delaware State Dept. of Public Instruction, Dover.

A study team for the Delaware Department of Public Instruction sought to discover a rescheduled school year design that could be adopted and used to increase the efficiency of staff and school facilities in Delaware. Through a search of the literature, visits to three school districts, and a conference with a nationally recognized consultant,…

Delaware K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper No. 21

ERIC Educational Resources Information Center

DiPerna, Paul

2014-01-01

The "Delaware K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research, Inc. (BRI), measures Delaware registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response levels…

Evaluation of Delaware Stars for Early Success: Year 1 Report. Research Report

ERIC Educational Resources Information Center

Schwartz, Heather L.; Karoly, Lynn A.; Le, Vi-Nhuan; Tamargo, Jennifer; Setodji, Claude Messan

2014-01-01

Delaware was in the first group of states to receive a federal grant in 2012 to improve early care and education services and increase the number of infants, toddlers, and preschool-age children in high-quality programs. One component of the state's grant is a rigorous validation process for Delaware Stars for Early Success, a voluntary quality…

78 FR 69310 - Endangered and Threatened Species; Protective Regulations for the Gulf of Maine Distinct...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-19

.... Receivers placed in areas of the Delaware and Hudson rivers, including low-salinity waters (salinity values... Atlantic sturgeon appeared one or more times within low-salinity waters (less than 0.5 ppt) of the Delaware... York Bight DPS sturgeon (29 of 58 captured) occurred in low- salinity waters of either the Delaware or...

Species-specific effects of a 1994 ice storm on radial tree growth in Delaware

Treesearch

Matthew Smolnik; Amy Hessl; J. J. Colbert

2006-01-01

Ice storms are recurrent disturbances that alter forest succession and forest structure throughout North America. However, long-term effects of ice storms on tree growth are largely unknown. Following a 1994 ice storm in Delaware, the Delaware Forest Service established seventy-five study plots to sample four species of trees (southern red oak [Quercus falcate...

33 CFR 100.T05-0443 - Safety Zone; Fireworks Display, Delaware River, New Hope, PA.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Delaware River, New Hope, PA. 100.T05-0443 Section 100.T05-0443 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.T05-0443 Safety Zone; Fireworks Display, Delaware River, New Hope, PA. (a) Location. The safety zone will restrict...

Delaware Forests 2013

Treesearch

Tonya W. Lister; Brett J. Butler; Susan J. Crocker; Cassandra M. Kurtz; Andrew J. Lister; William G. Luppold; William H. McWilliams; Patrick D. Miles; Randall S. Morin; Mark D. Nelson; Ronald J. Piva; Rachel I. Riemann; James E. Smith; James A. Westfall; Richard H. Widmann; Christopher W. Woodall

2017-01-01

This report summarizes the 2013 results of the annualized inventory of Delaware’s forests conducted by the U.S. Forest Service, Forest Inventory and Analysis program. Results are based on data collected from 389 plots located across the State. There are an estimated 362,000 acres of forest land in Delaware with a total live- tree volume of 936 million cubic feet. There...

Report of the River Master of the Delaware River for the Period December 1, 2002-November 30, 2003

USGS Publications Warehouse

Krejmas, Bruce E.; Paulachok, Gary N.; Blanchard, Stephen F.

2009-01-01

A Decree of the Supreme Court of the United States, entered in 1954, established the position of Delaware River Master within the U.S. Geological Survey (USGS). In addition, the Decree authorizes diversions of water from the Delaware River Basin and requires compensating releases from certain reservoirs, owned by New York City, to be made under the supervision and direction of the River Master. The Decree stipulates that the River Master will furnish reports to the Court, not less frequently than annually. This report is the 50th Annual Report of the River Master of the Delaware River. It covers the 2003 River Master report year; that is, the period from December 1, 2002 to November 30, 2003. During the report year, precipitation in the upper Delaware River Basin was 13.40 inches (131 percent) greater than the long-term average. Combined storage in Pepacton, Cannonsville, and Neversink Reservoirs was above the long-term median on December 1, 2002. Reservoir storage increased rapidly in mid-March 2003 and all the reservoirs filled and spilled. The reservoirs remained nearly full for the remainder of the report year. Delaware River operations throughout the report year were conducted as stipulated by the Decree. Diversions from the Delaware River Basin by New York City and New Jersey were in compliance with the Decree. Reservoir releases were made as directed by the River Master at rates designed to meet the flow objective for the Delaware River at Montague, New Jersey, on 10 days during the report year. Releases were made at experimental conservation rates - or rates designed to relieve thermal stress and protect the fishery and aquatic habitat in the tailwaters of the reservoirs - on all other days. During the report year, New York City and New Jersey complied fully with the terms of the Decree, and directives and requests of the River Master. As part of a long-term program, the quality of water in the Delaware Estuary between Trenton, New Jersey, and Reedy Island Jetty, Delaware, was monitored at various locations. Data on water temperature, specific conductance, dissolved oxygen, and pH were collected continuously by electronic instruments at four sites. In addition, selected water-quality data were collected at 3 sites on a monthly basis and at 19 sites on a semi-monthly basis.

Report of the River Master of the Delaware River for the Period December 1, 2003-November 30, 2004

USGS Publications Warehouse

Krejmas, Bruce E.; Paulachok, Gary N.; Blanchard, Stephen F.

2009-01-01

A Decree of the Supreme Court of the United States, entered in 1954, established the position of Delaware River Master within the U.S. Geological Survey (USGS). In addition, the Decree authorizes diversions of water from the Delaware River Basin and requires compensating releases from certain reservoirs, owned by New York City, to be made under the supervision and direction of the River Master. The Decree stipulates that the River Master will furnish reports to the Court, not less frequently than annually. This report is the 51st Annual Report of the River Master of the Delaware River. It covers the 2004 River Master report year; that is, the period from December 1, 2003, to November 30, 2004. During the report year, precipitation in the upper Delaware River Basin was 9.03 in. (121 percent) greater than the long-term average. Combined storage in Pepacton, Cannonsville, and Neversink Reservoirs was at a record high level on December 1, 2003. Reservoir storage remained high throughout the year with at least one reservoir spilling every month of the year. Delaware River operations throughout the year were conducted as stipulated by the Decree. Diversions from the Delaware River Basin by New York City and New Jersey were in compliance with the Decree. Reservoir releases were made as directed by the River Master at rates designed to meet the flow objective for the Delaware River at Montague, New Jersey, on 30 days during the report year. Releases were made at conservation rates - or rates designed to relieve thermal stress and protect the fishery and aquatic habitat in the tailwaters of the reservoirs - on all other days. During the report year, New York City and New Jersey complied fully with the terms of the Decree, and directives and requests of the River Master. As part of a long-term program, the quality of water in the Delaware Estuary between Trenton, New Jersey, and Reedy Island Jetty, Delaware, was monitored at various locations. Data on water temperature, specific conductance, dissolved oxygen, and pH were collected continuously by electronic instruments at four sites. In addition, selected water-quality data were collected at 3 sites on a monthly basis and at 19 sites on a semi-monthly basis.

Report of the River Master of the Delaware River for the period December 1, 2006–November 30, 2007

USGS Publications Warehouse

Krejmas, Bruce E.; Paulachok, Gary N.; Blanchard, Stephen F.

2011-01-01

A Decree of the Supreme Court of the United States, entered June 7, 1954, established the position of Delaware River Master within the U.S. Geological Survey (USGS). In addition, the Decree authorizes diversions of water from the Delaware River Basin and requires compensating releases from certain reservoirs, owned by New York City, to be made under the supervision and direction of the River Master. The Decree stipulates that the River Master will furnish reports to the Court, not less frequently than annually. This report is the 54th Annual Report of the River Master of the Delaware River. It covers the 2007 River Master report year—the period from December 1, 2006, to November 30, 2007. During the report year, precipitation in the upper Delaware River Basin was 46.72 inches (in.) or 107 percent of the long-term average. Combined storage in Pepacton, Cannonsville, and Neversink Reservoirs was high on December 1, 2006. Reservoir storage remained high throughout the winter, declined seasonally during the summer, and began to recover in mid-October. Delaware River operations throughout the year were conducted as stipulated by the Decree. Diversions from the Delaware River Basin by New York City and New Jersey were in full compliance with the Decree. Reservoir releases were made as directed by the River Master at rates designed to meet the flow objective for the Delaware River at Montague, New Jersey, on 123 days during the report year. Releases were made at conservation rates—or rates designed to relieve thermal stress and protect the fishery and aquatic habitat in the tailwaters of the reservoirs—on all other days. During the report year, New York City and New Jersey complied fully with the terms of the Decree, and directives and requests of the River Master. As part of a long-term program, the quality of water in the Delaware Estuary between Trenton, New Jersey, and Reedy Island Jetty, Delaware, was monitored at various locations. Data on water temperature, specific conductance, dissolved oxygen, and pH were collected continuously by electronic instruments at four sites. In addition, selected water-quality data were collected at 19 sites on a twice–monthly basis and at 3 sites on a monthly basis.

Report of the River Master of the Delaware River for the period December 1, 2004-November 30, 2005

USGS Publications Warehouse

Krejmas, Bruce E.; Paulachok, Gary N.; Blanchard, Stephen F.

2011-01-01

A Decree of the Supreme Court of the United States, entered in 1954, established the position of Delaware River Master within the U.S. Geological Survey. In addition, the Decree authorizes diversions of water from the Delaware River Basin and requires compensating releases from certain reservoirs, owned by New York City, to be made under the supervision and direction of the River Master. The Decree stipulates that the River Master will furnish reports to the Court, not less frequently than annually. This report is the 52nd Annual Report of the River Master of the Delaware River. It covers the 2005 River Master report year; that is, the period from December 1, 2004, to November 30, 2005. During the report year, precipitation in the upper Delaware River Basin was 7.56 in., or 117 percent of the long-term average. Combined storage in Pepacton, Cannonsville, and Neversink Reservoirs remained high from December 2004 to May 2005 and reached a record high level on April 3, 2005. Reservoir storage decreased steadily from May to early October, then increased rapidly through the end of November. Delaware River operations throughout the year were conducted as stipulated by the Decree. Diversions from the Delaware River Basin by New York City and New Jersey were in compliance with the Decree. Reservoir releases were made as directed by the River Master at rates designed to meet the flow objective for the Delaware River at Montague, New Jersey, on 120 days during the report year. Releases were made at conservation rates-or rates designed to relieve thermal stress and protect the fishery and aquatic habitat in the tailwaters of the reservoirs-on all other days. During the report year, New York City and New Jersey complied fully with the terms of the Decree, and directives and requests of the River Master. As part of a long-term program, the quality of water in the Delaware Estuary between Trenton, New Jersey, and Reedy Island Jetty, Delaware, was monitored at various locations. Data on water temperature, specific conductance, dissolved oxygen, and pH were collected continuously by electronic instruments at four sites. In addition, selected water-quality data were collected at 3 sites on a monthly basis and at 19 sites on a twice-monthly basis.

Report of the River Master of the Delaware River for the period December 1, 2005-November 30, 2006

USGS Publications Warehouse

Krejmas, Bruce E.; Paulachok, Gary N.; Blanchard, Stephen F.

2010-01-01

A Decree of the Supreme Court of the United States, entered June 7, 1954, established the position of Delaware River Master within the U.S. Geological Survey (USGS). In addition, the Decree authorizes diversions of water from the Delaware River Basin and requires compensating releases from certain reservoirs, owned by New York City, to be made under the supervision and direction of the River Master. The Decree stipulates that the River Master will furnish reports to the Court, not less frequently than annually. This report is the 53rd Annual Report of the River Master of the Delaware River. It covers the 2006 River Master report year-the period from December 1, 2005, to November 30, 2006. During the report year, precipitation in the upper Delaware River Basin was 55.03 inches (in.) or 126 percent of the long-term average. Combined storage in Pepacton, Cannonsville, and Neversink Reservoirs was above the long-term median level on December 1, 2005. Reservoir storage remained above long–term median levels throughout the report year. Delaware River operations during the year were conducted as stipulated by the Decree. Diversions from the Delaware River Basin by New York City and New Jersey were in full compliance with the Decree. Reservoir releases were made as directed by the River Master at rates designed to meet the flow objective for the Delaware River at Montague, New Jersey, on 27 days during the report year. Releases were made at conservation rates-or rates designed to relieve thermal stress and protect the fishery and aquatic habitat in the tailwaters of the reservoirs-on all other days. During the report year, New York City and New Jersey complied fully with the terms of the Decree, and directives and requests of the River Master. As part of a long-term program, the quality of water in the Delaware Estuary between Trenton, New Jersey, and Reedy Island Jetty, Delaware, was monitored at various locations. Data on water temperature, specific conductance, dissolved oxygen, and pH were collected continuously by electronic instruments at four sites. In addition, selected water-quality data were collected at 19 sites on a twice-monthly basis and at 3 sites on a monthly basis.

Report of the River Master of the Delaware River for the period December 1, 2007-November 30, 2008

USGS Publications Warehouse

Krejmas, Bruce E.; Paulachok, Gary N.; Blanchard, Stephen F.

2014-01-01

A Decree of the Supreme Court of the United States, entered June 7, 1954, established the position of Delaware River Master within the U.S. Geological Survey (USGS). In addition, the Decree authorizes diversions of water from the Delaware River Basin and requires compensating releases from certain reservoirs, owned by New York City, to be made under the supervision and direction of the River Master. The Decree stipulates that the River Master will furnish reports to the Court, not less frequently than annually. This report is the 55th Annual Report of the River Master of the Delaware River. It covers the 2008 River Master report year, the period from December 1, 2007, to November 30, 2008. During the report year, precipitation in the upper Delaware River Basin was 49.79 inches (in.) or 114 percent of the 67 report-year average. Combined storage in Pepacton, Cannonsville, and Neversink Reservoirs remained high from December 2007 to May 2008. Reservoir storage decreased seasonally from June to late October, then increased gradually through the end of November. Delaware River operations during the year were conducted as stipulated by the Decree. Diversions from the Delaware River Basin by New York City and New Jersey were in full compliance with the Decree. Reservoir releases were made as directed by the River Master at rates designed to meet the flow objective for the Delaware River at Montague, New Jersey, on 107 days during the report year. Releases were made at conservation rates—rates designed to relieve thermal stress and protect the fishery and aquatic habitat in the tailwaters of the reservoirs—on all other days. During the report year, New York City and New Jersey complied fully with the terms of the Decree, and directives and requests of the River Master. As part of a long-term program, the quality of water in the Delaware Estuary between Trenton, New Jersey, and Reedy Island Jetty, Delaware, was monitored at various locations. Data on water temperature, specific conductance, dissolved oxygen, and pH were collected continuously by electronic instruments at four sites. Data on water temperature and specific conductance were collected intermittently at one site. In addition, selected water-quality data were collected at 19 sites on a twice-monthly basis and at 3 sites on a monthly basis.

Kids Count in Delaware: Fact Book 1999 [and] Families Count in Delaware: Fact Book, 1999.

ERIC Educational Resources Information Center

Delaware Univ., Newark. Kids Count in Delaware.

This Kids Count Fact Book is combined with the Families Count Fact Book to provide information on statewide trends affecting children and families in Delaware. The Kids Count statistical profile is based on 10 main indicators of child well-being: (1) births to teens; (2) low birth weight babies; (3) infant mortality; (4) child deaths; (5) teen…

33 CFR 162.40 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal).

Code of Federal Regulations, 2010 CFR

2010-07-01

...., between Reedy Point, Delaware River, and Old Town Point Wharf, Elk River. (b) Speed. No vessel in the..., are required to travel at all times at a safe speed throughout the canal and its approaches so as to... Point and Welch Point. (f) Sailboats. Transiting the canal by vessels under sail is not permitted...

Kids Count in Delaware, Families Count in Delaware: Fact Book, 2002.

ERIC Educational Resources Information Center

Delaware Univ., Newark. Kids Count in Delaware.

This Kids Count Fact Book is combined with the Families Count Fact Book to provide information on statewide trends affecting children and families in Delaware. The Kids Count statistical profile is based on 11 main indicators of child well-being: (1) births to teens 15-17 years; (2) births to teens 10 to 14 years; (3) low birth weight babies; (3)…

Big Programs from a Small State: Less Commonly Taught Languages Find Their Home in Delaware Elementary Schools

ERIC Educational Resources Information Center

Fulkerson, Gregory

2009-01-01

This article describes three big programs from Delaware where the less commonly taught languages find their home in Delaware elementary schools. Odyssey Charter School, located in Wilmington, is one of the very few Greek-language-focused public schools in the nation. The school began in 2006 as a Greek immersion program that concentrated on the…

Collective Bargaining Agreement between the Board of Trustees of Delaware State College and the Delaware State College Chapter of the American Association of University Professors, 1986-1990.

ERIC Educational Resources Information Center

Delaware State Coll., Dover.

The collective bargaining agreement between the board of trustees and the Delaware State College chapter of the American Association of University Professors (AAUP) covering the period 1986 to 1990 is presented. Items covered in the agreement include: definitions; recognition of unit; non-discrimination; rights and privileges (professional dues…

Monitoring estuarine circulation and ocean waste dispersion using an integrated satellite-aircraft-drogue approach. [Delaware coast and Delaware Bay

NASA Technical Reports Server (NTRS)

Klemas, V. (Principal Investigator); Davis, G.; Wang, H.

1975-01-01

The author has identified the following significant results. An inexpensive, integrated drogue-aircraft-satellite approach was developed which is based on the Lagrangian technique and employs remotely tracked drogues and dyes together with satellite observation of natural tracers, such as suspended sediment. Results include current circulation studies in Delaware Bay in support of an oil slick movement model; investigations of the dispersion and movement of acid wastes dumped 40 miles off the Delaware coast; and coastal current circulation. In each case, the integrated drogue-aircraft-satellite approach compares favorably with other techniques on the basis of accuracy, cost effectiveness, and performance under severe weather conditions.

Mapping soil salinity and a fresh-water intrusion in three-dimensions using a quasi-3d joint-inversion of DUALEM-421S and EM34 data

NASA Astrophysics Data System (ADS)

Zare, Ehsan; Huang, Jingyi; Koganti, Triven; Triantafilis, John

2017-04-01

In order to understand the drivers of topsoil salinization, the distribution and movement of salt in accordance with groundwater need mapping. In this study, we described a method to map the distribution of soil salinity, as measured by the electrical conductivity of a saturated soil-paste extract (ECe), and in 3-dimensions around a water storage reservoir in an irrigated field near Bourke, New South Wales, Australia. A quasi-3d electromagnetic conductivity image (EMCI) or model of the true electrical conductivity (sigma) was developed using 133 apparent electrical conductivity (ECa) measurements collected on a 50 m grid and using various coil arrays of DUALEM-421S and EM34 instruments. For the DUALEM-421S we considered ECa in horizontal coplanar (i.e., 1 mPcon, 2 mPcon and 4 mPcon) and vertical coplanar (i.e., 1 mHcon, 2 mHcon and 4 mHcon) arrays. For the EM34, three measurements in the horizontal mode (i.e., EM34-10H, EM34-20H and EM34-40H) were considered. We estimated σ using a quasi-3d joint-inversion algorithm (EM4Soil). The best correlation (R2 = 0.92) between σ and measured soil ECe was identified when a forward modelling (FS), inversion algorithm (S2) and damping factor (lambda = 0.2) were used and using both DUALEM-421 and EM34 data; but not including the 4 m coil arrays of the DUALEM-421S. A linear regression calibration model was used to predict ECe in 3-dimensions beneath the study field. The predicted ECe was consistent with previous studies and revealed the distribution of ECe and helped to infer a freshwater intrusion from a water storage reservoir at depth and as a function of its proximity to near-surface prior stream channels and buried paleochannels. It was concluded that this method can be applied elsewhere to map the soil salinity and water movement and provide guidance for improved land management.|

Flood of September 18-19, 2004 in the Upper Delaware River Basin, New York

USGS Publications Warehouse

Brooks, Lloyd T.

2005-01-01

The interaction between the remnants of tropical depression Ivan and a frontal boundary in the upper Delaware River basin on September 18-19, 2004, produced 4 to more than 6 inches of rainfall over a 5-county area within a 24-hour period. Significant flooding occurred on the East Branch Delaware River and its tributaries, and the main stem of the Delaware River. The resultant flooding damaged more than 100 homes and displaced more than 1,000 people. All of the counties within the basin were declared Federal disaster areas, but flood damage in New York was most pronounced in Delaware, Orange, and Sullivan Counties. Flood damage totaled more than $10 million. Peak water-surface elevations at some study sites in the basin exceeded the 500-year flood elevation as documented in flood-insurance studies by the Federal Emergency Management Agency. Flood peaks at some long-term U.S. Geological Survey (USGS) streamflow-gaging stations were the highest ever recorded.

Burden of Multiple Chronic Conditions in Delaware, 2011–2014

PubMed Central

2016-01-01

The objective of this study was to use data from the Behavioral Risk Factor Surveillance System (BRFSS) to examine the prevalence of multiple chronic conditions (MCC) by select sociodemographic groups and determine the prevalence of most common MCC dyads and triads among Delaware adults. Combined data for 2011 through 2014 from BRFSS (n = 18,052) were analyzed to determine prevalence of MCC. Delaware adults were categorized as having 0, 1, 2, or 3 or more of the following diagnosed chronic conditions: angina, arthritis, asthma, cancer, chronic kidney disease, chronic obstructive pulmonary disease, diabetes, high blood pressure, high cholesterol, myocardial infarction (heart attack), obesity, or stroke. More than 65% of Delaware adults had at least 1 of the 12 selected chronic conditions. Furthermore, 36.8% of Delaware adults had MCC. The arthritis/obesity dyad and the arthritis/high blood pressure/high cholesterol triad were the 2 most prevalent MCC combinations. The findings of this study contribute information to the field of MCC research. PMID:27880632

Health and Safety Checklist for Early Care and Education Programs to Assess Key National Health and Safety Standards.

PubMed

Alkon, Abbey; Rose, Roberta; Wolff, Mimi; Kotch, Jonathan B; Aronson, Susan S

2016-01-01

The project aims were to (1) develop an observational Health and Safety Checklist to assess health and safety practices and conditions in early care and education (ECE) programs using Stepping Stones To Caring For Our Children, 3rd Edition national standards, (2) pilot test the Checklist, completed by nurse child care health consultants, to assess feasibility, ease of completion, objectivity, validity, and reliability, and (3) revise the Checklist based on the qualitative and quantitative results of the pilot study. The observable national health and safety standards were identified and then rated by health, safety, and child care experts using a Delphi technique to validate the standards as essential to prevent harm and promote health. Then, child care health consultants recruited ECE centers and pilot tested the 124-item Checklist. The pilot study was conducted in Arizona, California and North Carolina. The psychometric properties of the Checklist were assessed. The 37 participating ECE centers had 2627 children from ethnically-diverse backgrounds and primarily low-income families. The child care health consultants found the Checklist easy to complete, objective, and useful for planning health and safety interventions. The Checklist had content and face validity, inter-rater reliability, internal consistency, and concurrent validity. Based on the child care health consultant feedback and psychometric properties of the Checklist, the Checklist was revised and re-written at an 8th grade literacy level. The Health and Safety Checklist provides a standardized instrument of observable, selected national standards to assess the quality of health and safety in ECE centers.

Liquid crystal polymer substrate MMIC receiver modules for the ECE Imaging system on the DIII-D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Y.; Ye, Y.; Yu, J-H

A new generation of millimeter-wave heterodyne imaging receiver arrays has been developed and demonstrated on the DIII-D ECEI system. Improved circuit integration, allowing for absolute calibration, improved noise performance, and shielding from out-of-band emission, is made possible by using advanced liquid crystal polymer (LCP) substrates and MMIC (Monolithic Microwave Integrated Circuit) receiver chips. This array exhibits ~ 15 dB additional gain and > 30x reduction in noise temperature compared to the previous generation and provide ECEI capability for absolute 2-D electron temperature profile measurements. Each LCP horn-waveguide module houses a 3x3 mm GaAs MMIC receiver chip, which consists of amore » low noise amplifier (LNA), balanced mixer, local oscillator multiplier chain driven by ~12 GHz input via an RF cable to the enclosure box, and IF amplifier. A proof-of-principle instrument with 5 poloidal channels was installed on DIII-D in 2017. The full proof-of-principle system installation (20 poloidal x 8 radial channels) was commissioned early in 2018. The LCP ECEI system is used for pedestal region measurements, especially focusing on temperature evolution during ELM bursting. The DIII-D ECE Imaging signal has been significantly improved with extremely effective shielding of out-of-band microwave noise which plagued previous ECE Imaging studies on DIII-D. In H-mode ELM bursting, the radial propagation of electron heat flow has been detected on DIII-D. The LCP ECE Imaging is expected to be a valuable diagnostic tool for ELM physics investigations.« less

The role of early childhood education programmes in the promotion of child and adolescent mental health in low- and middle-income countries.

PubMed

Baker-Henningham, Helen

2014-04-01

There is growing evidence that early childhood education (ECE) interventions can reduce the loss of developmental potential of disadvantaged children in low- and middle-income countries (LAMIC). Less attention has been paid to the potential of these programmes to prevent child mental health problems and promote child well-being. Peer-reviewed journal articles describing controlled evaluations of ECE interventions in LAMIC were reviewed to identify studies with child mental health outcomes. Studies with proximal outcomes for child mental health including caregiver practices and caregiver mental health were also reviewed. Of 63 studies identified, 21 (33.33%) included child mental health outcomes; 12 of 16 studies with short-term measures showed benefits; 6 studies included a longer-term follow-up and all found benefits; 25 studies included caregiver outcomes: consistent benefits were found for caregiver practices (21 studies) and 6 of 9 studies that measured caregiver mental health reported benefits. Gains to child mental health may be most likely when ECE interventions include three main elements: (i) activities to increase child skills including cognition, language, self-regulation and social-emotional competence; (ii) training caregivers in the skills required to provide a cognitively stimulating and emotionally supportive environment; and (iii) attention to the caregivers' mental health, motivation and self-efficacy. Recommendations for the design and implementation of programmes are provided. ECE interventions are an important component of mental health prevention and promotion in LAMIC, and promoting child and caregiver well-being is a fundamental aspect of interventions to improve child development.

Runaway electron generation as possible trigger for enhancement of magnetohydrodynamic plasma activity and fast changes in runaway beam behavior

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pankratov, I. M., E-mail: pankratov@kipt.kharkov.ua, E-mail: rjzhou@ipp.ac.cn; Zhou, R. J., E-mail: pankratov@kipt.kharkov.ua, E-mail: rjzhou@ipp.ac.cn; Hu, L. Q.

2015-07-15

Peculiar phenomena were observed during experiments with runaway electrons: rapid changes in the synchrotron spot and its intensity that coincided with stepwise increases in the electron cyclotron emission (ECE) signal (cyclotron radiation of suprathermal electrons). These phenomena were initially observed in TEXTOR (Tokamak Experiment for Technology Oriented Research), where these events only occurred in the current decay phase or in discharges with thin stable runaway beams at a q = 1 drift surface. These rapid changes in the synchrotron spot were interpreted by the TEXTOR team as a fast pitch angle scattering event. Recently, similar rapid changes in the synchrotron spot andmore » its intensity that coincided with stepwise increases in the non-thermal ECE signal were observed in the EAST (Experimental Advanced Superconducting Tokamak) runaway discharge. Runaway electrons were located around the q = 2 rational magnetic surface (ring-like runaway electron beam). During the EAST runaway discharge, stepwise ECE signal increases coincided with enhanced magnetohydrodynamic (MHD) activity. This behavior was peculiar to this shot. In this paper, we show that these non-thermal ECE step-like jumps were related to the abrupt growth of suprathermal electrons induced by bursting electric fields at reconnection events during this MHD plasma activity. Enhancement of the secondary runaway electron generation also occurred simultaneously. Local changes in the current-density gradient appeared because of local enhancement of the runaway electron generation process. These current-density gradient changes are considered to be a possible trigger for enhancement of the MHD plasma activity and the rapid changes in runaway beam behavior.« less

Neurotensin-induced Proinflammatory Signaling in Human Colonocytes Is Regulated by β-Arrestins and Endothelin-converting Enzyme-1-dependent Endocytosis and Resensitization of Neurotensin Receptor 1*

PubMed Central

Law, Ivy Ka Man; Murphy, Jane E.; Bakirtzi, Kyriaki; Bunnett, Nigel W.; Pothoulakis, Charalabos

2012-01-01

The neuropeptide/hormone neurotensin (NT) mediates intestinal inflammation and cell proliferation by binding of its high affinity receptor, neurotensin receptor-1 (NTR1). NT stimulates IL-8 expression in NCM460 human colonic epithelial cells by both MAP kinase- and NF-κB-dependent pathways. Although the mechanism of NTR1 endocytosis has been studied, the relationship between NTR1 intracellular trafficking and inflammatory signaling remains to be elucidated. In the present study, we show that in NCM460 cells exposed to NT, β-arrestin-1 (βARR1), and β-arrestin-2 (βARR2) translocate to early endosomes together with NTR1. Endothelin-converting enzyme-1 (ECE-1) degrades NT in acidic conditions, and its activity is crucial for NTR1 recycling. Pretreatment of NCM460 cells with the ECE-1 inhibitor SM19712 or gene silencing of βARR1 or βARR2 inhibits NT-stimulated ERK1/2 and JNK phosphorylation, NF-κB p65 nuclear translocation and phosphorylation, and IL-8 secretion. Furthermore, NT-induced cell proliferation, but not IL-8 transcription, is attenuated by the JNK inhibitor, JNK(AII). Thus, NTR1 internalization and recycling in human colonic epithelial cells involves βARRs and ECE-1, respectively. Our results also indicate that βARRs and ECE-1-dependent recycling regulate MAP kinase and NF-κB signaling as well as cell proliferation in human colonocytes in response to NT. PMID:22416137

[Multiparametric 3T MRI in the routine staging of prostate cancer].

PubMed

Largeron, J P; Galonnier, F; Védrine, N; Alfidja, A; Boyer, L; Pereira, B; Boiteux, J P; Kemeny, J L; Guy, L

2014-03-01

To analyse the detection ability of a multiparametric 3T MRI with phased-array coil in comparison with the pathological data provided by the prostatectomy specimens. Prospective study of 30 months, including 74 patients for whom a diagnosis of prostate cancer had been made on randomized prostate biopsies, and all eligible to a radical prostatectomy. They all underwent multiparametric 3T MRI with pelvic phased-array coil including T2-weighted imaging (T2W), dynamic contrast-enhanced (DCE) and diffusion-weighted imaging (DWI) with an ADC mapping. Each gland was divided in octants. Three specific criteria have been sought (detection ability, capsular contact [CC] and extracapsular extension [ECE]), in comparison with the pathological data provided by the prostatectomy specimens. Five hundred and ninety-two octants were considered with 124 significant tumors (volume ≥ 0.1cm(3)). The general ability of tumor detection had a sensitivity, specificity, PPV and NPV respectively to 72.3%, 87.4%, 83.2% and 78.5%. The estimate of the CC and ECE had a high negative predictive power with specificities and VPN respectively to 96.4% and 95.4% for CC, and 97.5 and 97.7% for ECE. Multiparametric 3T MRI with pelvic phased-array coil appeared to be a reliable imaging technique in clinical and routine practice for the detection of localized prostate cancer. Estimation of the CC and millimeter ECE remains to be clarified, even if the negative predictive power for these parameters seems encouraging. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Runaway electron generation as possible trigger for enhancement of magnetohydrodynamic plasma activity and fast changes in runaway beam behavior

NASA Astrophysics Data System (ADS)

Pankratov, I. M.; Zhou, R. J.; Hu, L. Q.

2015-07-01

Peculiar phenomena were observed during experiments with runaway electrons: rapid changes in the synchrotron spot and its intensity that coincided with stepwise increases in the electron cyclotron emission (ECE) signal (cyclotron radiation of suprathermal electrons). These phenomena were initially observed in TEXTOR (Tokamak Experiment for Technology Oriented Research), where these events only occurred in the current decay phase or in discharges with thin stable runaway beams at a q = 1 drift surface. These rapid changes in the synchrotron spot were interpreted by the TEXTOR team as a fast pitch angle scattering event. Recently, similar rapid changes in the synchrotron spot and its intensity that coincided with stepwise increases in the non-thermal ECE signal were observed in the EAST (Experimental Advanced Superconducting Tokamak) runaway discharge. Runaway electrons were located around the q = 2 rational magnetic surface (ring-like runaway electron beam). During the EAST runaway discharge, stepwise ECE signal increases coincided with enhanced magnetohydrodynamic (MHD) activity. This behavior was peculiar to this shot. In this paper, we show that these non-thermal ECE step-like jumps were related to the abrupt growth of suprathermal electrons induced by bursting electric fields at reconnection events during this MHD plasma activity. Enhancement of the secondary runaway electron generation also occurred simultaneously. Local changes in the current-density gradient appeared because of local enhancement of the runaway electron generation process. These current-density gradient changes are considered to be a possible trigger for enhancement of the MHD plasma activity and the rapid changes in runaway beam behavior.

Selected Factors Related to Selective Service Rejection and Rejection Rate in Delaware (1967): A Study of the Characteristics of Young Men Failing to Meet Mental Qualifications for Military Service.

ERIC Educational Resources Information Center

Price, Jay R.

This study sought information about selective service rejection in Delaware, specifically rejectee characteristics, reasons for rejection, and the high rejection rate in Delaware. The basic design was a modified case study method in which a sample of individual records were examined. Differences between this sample and national samples were tested…

Kids Count in Delaware: Fact Book, 2000-2001 [and] Families Count in Delaware: Fact Book, 2000-2001.

ERIC Educational Resources Information Center

Delaware Univ., Newark. Kids Count in Delaware.

This Kids Count Fact Book is combined with the Families Count Fact Book to provide information on statewide trends affecting children and families in Delaware. The Kids Count statistical profile is based on 11 main indicators of child well-being: (1) births to teens 15 to 17 years; (2) births to teens 15 to 19 years; (3) low birth weight babies;…

Groundwater quality in the Delaware and St. Lawrence River Basins, New York, 2010

USGS Publications Warehouse

Nystrom, Elizabeth A.

2012-01-01

Water quality in both study areas is generally good, but concentrations of some constituents equaled or exceeded current or proposed Federal or New York State drinking-water standards. The standards exceeded are color (one sample in the St. Lawrence study area), pH (three samples in the Delaware study area), sodium (one sample in the St. Lawrence study area), total dissolved solids (one sample in the St. Lawrence study area), aluminum (one sample in the Delaware study area and one sample in the St. Lawrence study area), iron (seven samples in the St. Lawrence study area), manganese (one sample in the Delaware study area and five samples in the St. Lawrence study area), gross alpha radioactivity (one sample in the St. Lawrence study area), radon-222 (10 samples in the Delaware study area and 14 samples in the St. Lawrence study area), and bacteria (5 samples in the Delaware study area and 10 samples in the St. Lawrence study area). E. coli bacteria were detected in samples from two wells in the St. Lawrence study area. Concentrations of chloride, fluoride, sulfate, nitrate, nitrite, antimony, arsenic, barium, beryllium, cadmium, chromium, copper, lead, mercury, selenium, silver, thallium, zinc, and uranium did not exceed existing drinking-water standards in any of the samples collected.

Evaluating temporal changes in stream condition in three New Jersey rive basins by using an index of biotic integrity

USGS Publications Warehouse

Chang, Ming; Kennen, Jonathan G.; Del Corso, Ellyn

2000-01-01

An index of biotic integrity (!B!) modified for New Jersey streams was used to compare changes in stream condition from the 1970s to the 1990s in Delaware, Passaic, and Raritan River Basins. Stream condition was assessed at 88 sampling locations. Mean IBI scores for all basins increased from the 1970s to the 1990s, but the stream-condition category improved (from fair to good) only for the Delaware River Basin. The number of benthic insectivores and the proportion of insectivorous cyprinds increased in all three basins; however, the number of white suckers decreased significantly only in the Delaware River Basin. Results of linear-regression analysis indicate a significant correlation between the percentage of altered land in the basin and change in IBI score (1970s to 1990s) for Delaware River sites. Results of analysis of variance of the rank-transformed IBI scores for the 1970s and 1990s indicate that the three basins was equal in the 1970s. Results of a multiple-comparison test demonstrated that the 1990s IBI values for the Delaware River Basin differed significantly from those for the Passaic and Raritan River Basins. Many factors, such as the imposition of the more stringent standards on water-water and industrial discharges during the 1980s and changes in land-use practices, likely contributed to the change in the Delaware River Basin. A general increase in IBI values for the Passaic, Raritan, and Delaware River Basins over the past 25 years appears to reflect overall improvements in water quality.

Estimation of daily mean streamflow for ungaged stream locations in the Delaware River Basin, water years 1960–2010

USGS Publications Warehouse

Stuckey, Marla H.

2016-06-09

The ability to characterize baseline streamflow conditions, compare them with current conditions, and assess effects of human activities on streamflow is fundamental to water-management programs addressing water allocation, human-health issues, recreation needs, and establishment of ecological flow criteria. The U.S. Geological Survey, through the National Water Census, has developed the Delaware River Basin Streamflow Estimator Tool (DRB-SET) to estimate baseline (minimally altered) and altered (affected by regulation, diversion, mining, or other anthropogenic activities) and altered streamflow at a daily time step for ungaged stream locations in the Delaware River Basin for water years 1960–2010. Daily mean baseline streamflow is estimated by using the QPPQ method to equate streamflow expressed as a percentile from the flow-duration curve (FDC) for a particular day at an ungaged stream location with the percentile from a FDC for the same day at a hydrologically similar gaged location where streamflow is measured. Parameter-based regression equations were developed for 22 exceedance probabilities from the FDC for ungaged stream locations in the Delaware River Basin. Water use data from 2010 is used to adjust the baseline daily mean streamflow generated from the QPPQ method at ungaged stream locations in the Delaware River Basin to reflect current, or altered, conditions. To evaluate the effectiveness of the overall QPPQ method contained within DRB-SET, a comparison of observed and estimated daily mean streamflows was performed for 109 reference streamgages in and near the Delaware River Basin. The Nash-Sutcliffe efficiency (NSE) values were computed as a measure of goodness of fit. The NSE values (using log10 streamflow values) ranged from 0.22 to 0.98 (median of 0.90) for 45 streamgages in the Upper Delaware River Basin and from -0.37 to 0.98 (median of 0.79) for 41 streamgages in the Lower Delaware River Basin.

Orientation dependent cyclic stability of the elastocaloric effect in textured Ni-Mn-Ga alloys

NASA Astrophysics Data System (ADS)

Wei, Longsha; Zhang, Xuexi; Liu, Jian; Geng, Lin

2018-05-01

High-performance elastocaloric materials require a large reversible elastocaloric effect and long life cyclic stability. Here, we fabricated textured polycrystalline Ni50.4Mn27.3Ga22.3 alloys by cost-effective casting method to create a <001> texture. A strong correlation between the cyclic stability and the crystal orientation was demonstrated. A large reversible adiabatic temperature change ΔT ˜6 K was obtained when the external stress was applied parallel to <001> direction. However, the ΔT decreased rapidly after 50 cycles, showing an unstable elastocaloric effect (eCE). On the other hand, when the external stress was applied perpendicular to <001>, the adiabatic ΔT was smaller ˜4 K, but was stable over 100 cycles. This significantly enhanced eCE stability was related to the high yield strength, low transformation strain and much higher crack initiation-propagation resistances perpendicular to <001> direction. This study provides a feasible strategy for optimizing the eCE property by creation of the texture structure in polycrystalline Ni-Mn-Ga and Ni-Mn-X (X= In, Sn, Sb) alloys.

Influence of groundwater on distribution of dwarf wedgemussels (Alasmidonta heterodon) in the upper reaches of the Delaware River, northeastern USA

USGS Publications Warehouse

Rosenberry, Donald O.; Briggs, Martin A.; Voytek, Emily B.; Lane, John W.

2016-01-01

The remaining populations of the endangered dwarf wedgemussel (DWM) (Alasmidonta heterodon) in the upper Delaware River, northeastern USA, were hypothesized to be located in areas of greater-than-normal groundwater discharge to the river. We combined physical (seepage meters, monitoring wells and piezometers), thermal (fiber-optic distributed temperature sensing, infrared, vertical bed-temperature profiling), and geophysical (electromagnetic-induction) methods at several spatial scales to characterize known DWM habitat and explore this hypothesis. Numerous springs were observed using visible and infrared imaging along the river banks at all three known DWM-populated areas, but not in adjacent areas where DWM were absent. Vertical and lateral groundwater gradients were toward the river along all three DWM-populated reaches, with median upward gradients 3 to 9 times larger than in adjacent reaches. Point-scale seepage-meter measurements indicated that upward seepage across the riverbed was faster and more consistently upward at DWM-populated areas. Discrete and areally distributed riverbed-temperature measurements indicated numerous cold areas of groundwater discharge during warm summer months; all were within areas populated by DWM. Electromagnetic-induction measurements, which may indicate riverbed geology, showed patterning but little correlation between bulk streambed electromagnetic conductivity and areal distribution of DWM. In spite of complexity introduced by hyporheic exchange, multiple lines of research provide strong evidence that DWM are located within or directly downstream of areas of substantial focused groundwater discharge to the river. Broad scale thermal-reconnaissance methods (e.g., infrared) may be useful in locating and protecting other currently unknown mussel populations.

Strategic Reinvention: The Rodel Foundation of Delaware's Journey to Catalyzing a System of World-Class Schools. Principles for Effective Education Grantmaking. Case Study No. 10

ERIC Educational Resources Information Center

Jenkins, Lynn; Wisdom, Michelle

2014-01-01

As the summer of 2014 began, Paul Herdman, President and CEO of the Rodel Charitable Foundation of Delaware, paused to reflect on what Delaware had accomplished over the past decade in the public education realm. Academic standards had been raised across the K-12 system, and a new assessment system aligned to those standards was being implemented.…

Importance of Surface-Ground Water Interaction to Corps Total Water Management: Regional and National Examples

DTIC Science & Technology

1991-02-01

Trenton to Wilmington. Here the Potomac-Raritan- Magothy aquifer system outcrops along approximately 65 miles of the Delaware River as it enters the...industrial supply, ground water from the Potomac-Raritan- Magothy aquifer system flowed to the Delaware River. As the area became populated and industrialized...Delaware River, precipitation, or other freshwater sources to prevent saltwater intrusion of the Potomac-Raritan- Magothy aquifer. Without replenishment

Application of automated multispectral analysis to Delaware's coastal vegetation mapping

NASA Technical Reports Server (NTRS)

Klemas, V.; Daiber, F.; Bartlett, D.; Crichton, O.; Fornes, A.

1973-01-01

A baseline mapping project was undertaken in Delaware's coastal wetlands as a prelude to an evaluation of the relative value of different parcels of marsh and the setting of priorities for use of these marshes. A description of Delaware's wetlands is given and a mapping approach is discussed together with details concerning an automated analysis. The precision and resolution of the analysis was limited primarily by the quality of the imagery used.

Monkey search algorithm for ECE components partitioning

NASA Astrophysics Data System (ADS)

Kuliev, Elmar; Kureichik, Vladimir; Kureichik, Vladimir, Jr.

2018-05-01

The paper considers one of the important design problems – a partitioning of electronic computer equipment (ECE) components (blocks). It belongs to the NP-hard class of problems and has a combinatorial and logic nature. In the paper, a partitioning problem formulation can be found as a partition of graph into parts. To solve the given problem, the authors suggest using a bioinspired approach based on a monkey search algorithm. Based on the developed software, computational experiments were carried out that show the algorithm efficiency, as well as its recommended settings for obtaining more effective solutions in comparison with a genetic algorithm.

Reconnaissance of the hydrology, water quality, and sources of bacterial and nutrient contamination in the Ozark Plateaus aquifer system and Cave Springs Branch of Honey Creek, Delaware County, Oklahoma, March 1999-March 2000

USGS Publications Warehouse

Schlottmann, Jamie L.; Tanner, Ralph S.; Samadpour, Mansour

2000-01-01

A reconnaissance investigation of hydrology and water quality was conducted to evaluate possible sources of bacteria and nutrient contamination in the Cave Springs Branch basin and the underlying karstic Ozark Plateau aquifer system. Objectives were to: (1) determine the directions of ground-water flow in the basin and determine whether Cave Springs Branch interacts with ground water, (2) compare water quality in Cave Springs Branch with water quality in nearby wells to determine whether the stream is contaminating nearby wells, and (3) determine sources of fecal coliform bacteria and nitrate contamination in Cave Springs Branch and ground water. Potential sources of bacteria and nitrate in the area include cultivated agriculture, cow and horse on pasture, poultry production, households, and wildlife. Presence of fecal coliform and fecal streptococcal bacteria directly indicate fecal contamination and the potential for the presence of other pathogenic organisms in a water supply. Nitrate in drinking water poses health risks and may indicate the presence of additional contaminants. Fecal coliform bacteria colony counts were least in wells, intermediate in the poultry-processing plant wastewater outfall and Honey Creek above the confluence with Cave Springs Branch, and greatest in Cave Springs Branch. Bacteria strains and resistance to antibiotics by some bacteria indicate that livestock may have been sources of some bacteria in the water samples. Multiple antibiotic resistances were not present in the isolates from the water samples, indicating that the bacteria may not be from human or poultry sources. Ribotyping indicates that Escherichia coli bacteria in water samples from the basin were from bird, cow, horse, dog, deer, and human sources. The presence of multiple ribotypes from each type of animal source except bird indicates that most of the bacteria are from multiple populations of source animals. Identifiable sources of bacteria in Cave Springs Branch at the state line were dominantly cow and horse with one ribotype from bird. Escherichia coli was detected in only one well sample. Bacterial ribotypes in water from that upgradient well indicated human and dog feces as sources for bacteria, and that on site wastewater treatment may not always be adequate in these highly permeable soils. Greater concentrations of nitrate in Cave Springs Branch and O'Brien Spring relative to the poultry-processing plant wastewater outfall may be due, in part, to conversion of ammonia from poultry processing plant wastewater. The poultry-processing plant wastewater outfall sample collected in March 2000 contained greater concentrations of ammonia and total organic nitrogen plus ammonia than the spring, stream, and well samples collected during August 1999. Cave Springs Branch and Honey Creek contributed approximately equal loads of nitrogen to Honey Creek below the confluence and the greatest loads of nitrogen were introduced to Cave Springs Branch by the poultry processing plant wastewater outfall and O'Brien Spring. Nitrate concentrations in upgradient well samples ranged from 0.38 to 4.60 milligrams per liter, indicating that there are sources of ground-water nitrogen other than Cave Springs Branch, such as animal waste, fertilizer, or human waste. Nitrogen compounds in water from wells downgradient of Cave Springs Branch may be from Cave Springs Branch, fertilizers, animal waste, or human waste.

Persistence and Agility: The Rodel Foundation of Delaware's Efforts to Transform Delaware's Education System. Principles for Effective Education Grantmaking. Case Study Number 8

ERIC Educational Resources Information Center

Alvord, Sarah

2012-01-01

It was 8:45 a.m. on Monday, March 29, 2010, when Paul Herdman got the stunning news. Just two states had won first-round grants in the Race to the Top competition, the largest federal competition of its kind in American history, out of 40 state applicants. Herdman joined the Rodel Foundation of Delaware (Rodel) as President and CEO in 2004. The…

Water quality in the surficial aquifer near agricultural areas in the Delaware Coastal Plain, 2014

USGS Publications Warehouse

Fleming, Brandon J.; Mensch, Laura L.; Denver, Judith M.; Cruz, Roberto M.; Nardi, Mark R.

2017-07-27

The U.S. Geological Survey, in cooperation with the Delaware Department of Agriculture, developed a network of wells to monitor groundwater quality in the surficial aquifer of the Delaware Coastal Plain. Well-drained soils, a flat landscape, and accessible water in the Delaware Coastal Plain make for a productive agricultural setting. As such, agriculture is one of the largest industries in the State of Delaware. This setting enables the transport of chemicals from agriculture and other land uses to shallow groundwater. Efforts to mitigate nutrient transport to groundwater by the implementation of agricultural best management practices (BMPs) have been ongoing for several decades. To measure the effectiveness of BMPs on a regional scale, a network of 48 wells was designed to measure shallow groundwater quality (particularly nitrate) over time near agricultural land in the Delaware Coastal Plain. Water characteristics, major ions, nutrients, and dissolved gases were measured in groundwater samples collected from network wells during fall 2014. Wells were organized into three groups based on their geochemical similarity and these groups were used to describe nitrate and chloride concentrations and factors that affect the variability among the groups. The results from this study are intended to establish waterquality conditions in 2014 to enable comparison of future conditions and evaluate the effectiveness of agricultural BMPs on a regional scale.

2. Signal Tower, looking east. Delaware, Lackawanna & Western ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Signal Tower, looking east. - Delaware, Lackawanna & Western Railroad, Scranton Yards, Mattes Street Signal Tower, 80 feet Southwest of Railroad Alley & Cedar Avenue, Scranton, Lackawanna County, PA

PAH, PCB, TPH and mercury in surface sediments of the Delaware River Estuary and Delmarva Peninsula, USA.

PubMed

Kim, A W; Vane, C H; Moss-Hayes, V; Engelhart, S E; Kemp, A C

2018-04-01

Surface sediment concentrations of polycyclic aromatic hydrocarbons (PAH) and polychlorinated biphenyls (PCB), total petroleum hydrocarbons (TPH) and mercury, were compared from two areas with contrasting land use history, the industrial Delaware Estuary and the rural Delmarva Peninsula (USA). TPH in the Delaware (38-616mg/kg) and saturate/aromatic fractions suggested petroleum/industrial sources compared to biogenic sources in the Delmarva coastal control (<34-159mg/kg). Within the Delaware the ∑PAH18 ranged from 3749 to 22,324μg/kg with isomeric ratios indicative of petroleum combustion source/s, conversely, those in the Delmarva (5-2139μg/kg) also yielded relatively higher perylene that were consistent with natural background levels derived from vegetation/coal combustion source/s. ∑PCB(tri-hepta) concentrations in the Delmarva (0.6-6.5μg/kg) were less than the threshold effect concentration (TEC), whereas the Delaware had received much higher PCB loading (18.1-136.8μg/kg) as evidenced by a significantly higher amounts in some samples (>TEC). Copyright © 2017 Elsevier Ltd. All rights reserved.

7. View looking northwest along Cedar Avenue Bridge. Delaware, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. View looking northwest along Cedar Avenue Bridge. - Delaware, Lackawanna & Western Railroad, Scranton Yards, Cedar Avenue Bridge, Spanning Cedar Avenue at Railroad Alley, Scranton, Lackawanna County, PA

3. West elevation of Signal Tower. Delaware, Lackawanna & ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. West elevation of Signal Tower. - Delaware, Lackawanna & Western Railroad, Scranton Yards, Mattes Street Signal Tower, 80 feet Southwest of Railroad Alley & Cedar Avenue, Scranton, Lackawanna County, PA

Water-level data for the industrial area northwest of Delaware City, Delaware, 1993-94

USGS Publications Warehouse

Donnelly, C.A.; Hinaman, K.C.

1996-01-01

Water-level data for 171 wells and one surface-water site on Red Lion Creek in the industrial area northwest of Delaware City, Delaware, are presented for 1993 and 1994. Eight sets of synoptic ground- water-level measurements collected between April 1993 and September 1994, and locations and field notes for the 171 wells are presented. A hydrograph from December 19, 1993 through November 8, 1994 is presented for one surface-water site on Red Lion Creek in the industrial area. Hydrographs from October 15, 1993 through November 8, 1994 are presented for eight wells screened in the water- table aquifer. The U.S. Army Corps of Engineers collected the synoptic ground-water-level measurements. The U.S. Geological Survey collected the continuously recorded water-level data.

Monitoring coastal water properties and current circulation with ERTS-1. [Delaware Bay

NASA Technical Reports Server (NTRS)

Klemas, V.; Otley, M.; Wethe, C.; Rogers, R.

1974-01-01

Imagery and digital tapes from nine successful ERTS-1 passes over Delaware Bay during different portions of the tidal cycle have been analyzed with special emphasis on turbidity, current circulation, waste disposal plumes and convergent boundaries between different water masses. ERTS-1 image radiance correlated well with Secchi depth and suspended sediment concentration. Circulation patterns observed by ERTS-1 during different parts of the tidal cycle, agreed well with predicted and measured currents throughout Delaware Bay. Convergent shear boundaries between different water masses were observed from ERTS-1. In several ERTS-1 frames, waste disposal plumes have been detected 36 miles off Delaware's Atlantic coast. The ERTS-1 results are being used to extend and verify hydrodynamic models of the bay, developed for predicting oil slick movement and estimating sediment transport.

Augmented Reality Robot-assisted Radical Prostatectomy: Preliminary Experience.

PubMed

Porpiglia, Francesco; Fiori, Cristian; Checcucci, Enrico; Amparore, Daniele; Bertolo, Riccardo

2018-05-01

To present our preliminary experience with augmented reality robot-assisted radical prostatectomy (AR-RARP). From June to August 2017, patients candidate to RARP were enrolled and underwent high-resolution multi-parametric magnetic resonance imaging (1-mm slices) according to dedicated protocol. The obtained three-dimensional (3D) reconstruction was integrated in the robotic console to perform AR-RARP. According to the staging at magnetic resonance imaging or reconstruction, in case of cT2 prostate cancer, intrafascial nerve sparing (NS) was performed: a mark was placed on the prostate capsule to indicate the virtual underlying intraprostatic lesion; in case of cT3, standard NS AR-RARP was scheduled with AR-guided biopsy at the level of suspected extracapsular extension (ECE). Prostate specimens were scanned to assess the 3D model concordance. Sixteen patients underwent intrafascial NS technique (cT2), whereas 14 underwent standard NS+ selective biopsy of suspected ECE (cT3). Final pathology confirmed clinical staging. Positive surgical margins' rate was 30% (no positive surgical margins in pT2). In patients whose intraprostatic lesions were marked, final pathology confirmed lesion location. In patients with suspected ECE, AR-guided selective biopsies confirmed the ECE location, with 11 of 14 biopsies (78%) positive for prostate cancer. Prostate specimens were scanned with finding of a good overlap. The mismatch between 3D reconstruction and scanning ranged from 1 to 5 mm. In 85% of the entire surface, the mismatch was <3 mm. In our preliminary experience, AR-RARP seems to be safe and effective. The accuracy of 3D reconstruction seemed to be promising. This technology has still limitations: the virtual models are manually oriented and rigid. Future collaborations with bioengineers will allow overcoming these limitations. Copyright © 2018 Elsevier Inc. All rights reserved.

Strength of obesity prevention interventions in early care and education settings: A systematic review.

PubMed

Ward, Dianne S; Welker, Emily; Choate, Ashley; Henderson, Kathryn E; Lott, Megan; Tovar, Alison; Wilson, Amanda; Sallis, James F

2017-02-01

2010-2015; INTERNATIONAL: Given the high levels of obesity in young children, numbers of children in out-of-home care, and data suggesting a link between early care and education (ECE) participation and overweight/obesity, obesity prevention in ECE settings is critical. As the field has progressed, a number of interventions have been reviewed yet there is a need to summarize the data using more sophisticated analyses to answer questions on the effectiveness of interventions. We conducted a systematic review of obesity prevention interventions in center-based ECE settings published between 2010 and 2015. Our goal was to identify promising intervention characteristics associated with successful behavioral and anthropometric outcomes. A rigorous search strategy resulted in 43 interventions that met inclusion criteria. We developed a coding strategy to assess intervention strength, used a validated study quality assessment tool, and presented detailed descriptive information about interventions (e.g., target behaviors, intervention strategies, and mode of delivery). Intervention strength was positively correlated with reporting of positive anthropometric outcomes for physical activity, diet, and combined interventions, and parent engagement components increased the strength of these relationships. Study quality was modestly related to percent successful healthy eating outcomes. Relationships between intervention strength and behavioral outcomes demonstrated negative relationships for all behavioral outcomes. Specific components of intervention strength (number of intervention strategies, potential impact of strategies, frequency of use, and duration of intervention) were correlated with some of the anthropometric and parent engagement outcomes. The review provided tentative evidence that multi-component, multi-level ECE interventions with parental engagement are most likely to be effective with anthropometric outcomes. Copyright © 2016 Elsevier Inc. All rights reserved.

Investigating the Et-1/SphK/S1P Pathway as a Novel Approach for the Prevention of Inflammation-Induced Preterm Birth.

PubMed

Giusto, Kiersten; Ashby, Charles R

2018-01-30

Preterm birth (PTB), defined as birth before 37 completed weeks of gestation, occurs in up to 18 percent of births worldwide and accounts for the majority of perinatal morbidity and mortality. While the single most common cause of PTB has been identified as inflammation, safe and effective pharmacotherapy to prevent PTB has yet to be developed. Our group has used an in vivo model of inflammation driven PTB, biochemical methods, pharmacological approaches, a novel endothelin receptor antagonist that we synthesized and RNA knockdown to help establish the role of endothelin-1 (ET-1) in inflammation-associated PTB. Further, we have used our in vivo model to test whether sphingosine kinase, which acts downstream of ET-1, plays a role in PTB. We have shown that levels of endothelin converting enzyme-1 (ECE-1) and ET-1 are increased when PTB is induced in timed pregnant mice with lipopolysaccharide (LPS) and that blocking ET-1 action, pharmacologically or using ECE-1 RNA silencing, rescues LPS-induced mice from PTB. ET-1 activates the sphingosine kinase/sphingosine-1-phosphate (SphK/S1P) pathway. S1P, in turn, is an important signaling molecule in the pro-inflammatory response. Interestingly, we have shown that SphK inhibition also prevents LPS-induced PTB in timed pregnant mice. Further, we showed that SphK inhibition suppresses the ECE-1/ET-1 axis, implicating positive feedback regulation of the SphK/S1P/ECE-1/ET-1 axis. The ET-1/SphK/SIP pathway is a potential pharmacotherapeutic target for the prevention of PTB. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Efficacy and Safety of Oritavancin Relative to Vancomycin for Patients with Acute Bacterial Skin and Skin Structure Infections (ABSSSI) in the Outpatient Setting: Results From the SOLO Clinical Trials.

PubMed

Lodise, Thomas P; Redell, Mark; Armstrong, Shannon O; Sulham, Katherine A; Corey, G Ralph

2017-01-01

The objective of this analysis was to evaluate the efficacy and safety of oritavancin compared with vancomycin for patients with acute bacterial skin and skin structure infections (ABSSSIs) who received treatment in the outpatient setting in the Phase 3 SOLO clinical trials. SOLO I and SOLO II were 2 identically designed comparative, multicenter, double-blind, randomized studies to evaluate the efficacy and safety of a single 1200-mg dose of intravenous (IV) oritavancin versus 7-10 days of twice-daily IV vancomycin for the treatment of ABSSSI. Protocols were amended to allow enrolled patients to complete their entire course of antimicrobial therapy in an outpatient setting. The primary efficacy outcome was a composite endpoint (cessation of spread or reduction in size of the baseline lesion, absence of fever, and no rescue antibiotic at early clinical evaluation [ECE]) (48 to 72 hours). Key secondary endpoints included investigator-assessed clinical cure 7 to 14 days after end of treatment (posttherapy evaluation [PTE]) and 20% or greater reduction in lesion area at ECE. Safety was assessed until day 60. Seven hundred ninety-two patients (oritavancin, 392; vancomycin, 400) received entire course of treatment in the outpatient setting. Efficacy response rates at ECE and PTE were similar (primary composite endpoint at ECE: 80.4% vs 77.5% for oritavancin and vancomycin, respectively) as was incidence of adverse events. Five patients (1.3%) who received oritavancin and 9 (2.3%) vancomycin patients were subsequently admitted to a hospital. Oritavancin provides a single-dose alternative to multidose vancomycin for treatment of ABSSSI in the outpatient setting. © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Report for the River Master of the Delaware River for the Period December 1, 2001-November 30, 2002

USGS Publications Warehouse

Krejmas, Bruce E.; Paulachok, Gary N.; Carswell, William J.

2006-01-01

A Decree of the United States Supreme Court in 1954 established the position of Delaware River Master within the U.S. Geological Survey. In addition, the Decree authorizes diversions of water from the Delaware River Basin and requires compensating releases from certain reservoirs, owned by New York City, to be made under the supervision and direction of the River Master. The Decree stipulates that the River Master will furnish reports to the Court, not less frequently than annually. This report is the 49th Annual Report of the River Master of the Delaware River. It covers the 2002 River Master report year, that is, the period from December 1, 2001, to November 30, 2002. During the report year, precipitation in the upper Delaware River Basin was 2.73 in. greater than the long-term average. Combined storage in Pepacton, Cannonsville, and Neversink Reservoirs was at a record low level on December 1, 2001. Reservoir storage increased steadily from mid-winter until late June. Storage declined steadily from early July to mid-October then increased through the end of the year. Delaware River operations were conducted at reduced levels from December 1, 2001, to May 25, 2002, when drought emergency conditions prevailed, and as prescribed by the Decree from May 26, 2002, to November 30, 2002. Diversions from the Delaware River Basin by New York City and New Jersey were in compliance with the terms of the Decree or with the reduced limits in effect during drought emergency conditions. Reservoir releases were made as directed by the River Master at rates designed to meet the flow objective for the Delaware River at Montague, New Jersey, on 101 days during the report year. Releases were made at experimental conservation rates-or rates designed to relieve thermal stress and protect the fishery and aquatic habitat in the tailwaters of the reservoirs-on all other days. During the report year, New York City and New Jersey complied fully with the terms of the Decree, and during drought emergency conditions, with the terms of the 'Interstate Water Management Recommendations of the Parties to the Decree' (DRBC Resolution 83-13), and directives and requests of the River Master. As part of a long-term program, the quality of water in the Delaware Estuary between Trenton, New Jersey, and Reedy Island Jetty, Delaware, was monitored at various locations. Data on water temperature, specific conductance, dissolved oxygen, and pH were collected by electronic instruments at four sites, and data on water temperature and specific conductance were collected at one site. In addition, selected water-quality data were collected at 3 sites on a monthly basis and at 19 sites on a semimonthly basis.

33 CFR 167.172 - Off Delaware Bay: Southeastern approach.

Code of Federal Regulations, 2013 CFR

2013-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.172 Off Delaware Bay: Southeastern...

33 CFR 167.172 - Off Delaware Bay: Southeastern approach.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.172 Off Delaware Bay: Southeastern...

33 CFR 167.172 - Off Delaware Bay: Southeastern approach.

Code of Federal Regulations, 2012 CFR

2012-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.172 Off Delaware Bay: Southeastern...

33 CFR 167.172 - Off Delaware Bay: Southeastern approach.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.172 Off Delaware Bay: Southeastern...

33 CFR 167.172 - Off Delaware Bay: Southeastern approach.

Code of Federal Regulations, 2014 CFR

2014-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.172 Off Delaware Bay: Southeastern...

A summary of the test procedures and operational details of a Delaware River and an ocean dumping pollution monitoring experiment conducted 28 August 1975

NASA Technical Reports Server (NTRS)

Hypes, W. D.; Ohlhorst, C. W.

1977-01-01

Two remote sensor evaluation experiments are discussed. One experiment was conducted at the DuPont acid-dump site off the Delaware coast. The second was conducted at an organic waste outfall in the Delaware River. The operational objective of obtaining simultaneous sea truth sampling with remote sensors overpasses was met. Descriptions of the test sites, sensors, sensor platforms, flight lines, sea truth data collected, and operational chronology are presented.

Detailed Project Report. Small Beach Erosion Control Project. Broadkill Beach, Delaware.

DTIC Science & Technology

1972-02-01

this study. TABLE 3 ESTIMATED PROPERTY VALUES IN BROADKILL BEACH (July 1971) Beach Front Property* Entire Community Present Present Fair Value Fair ...between the 14th and 50th year reflect only the land, houses and utilities (minus salvage value estimated at 25% of the fair value ) that are located... Value $ $ 1,221,000 2,866,000 ftExcluding beach area. >4’ 5 11. The water entering Delaware Bay from Delaware River is polluted, but the degree of

33 CFR 167.171 - Off Delaware Bay: Eastern approach.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.171 Off Delaware Bay: Eastern approach...

33 CFR 167.174 - Off Delaware Bay: Precautionary area.

Code of Federal Regulations, 2012 CFR

2012-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.174 Off Delaware Bay: Precautionary area...

33 CFR 167.174 - Off Delaware Bay: Precautionary area.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.174 Off Delaware Bay: Precautionary area...

33 CFR 167.171 - Off Delaware Bay: Eastern approach.

Code of Federal Regulations, 2012 CFR

2012-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.171 Off Delaware Bay: Eastern approach...

33 CFR 167.174 - Off Delaware Bay: Precautionary area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.174 Off Delaware Bay: Precautionary area...

33 CFR 167.174 - Off Delaware Bay: Precautionary area.

Code of Federal Regulations, 2013 CFR

2013-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.174 Off Delaware Bay: Precautionary area...

33 CFR 167.171 - Off Delaware Bay: Eastern approach.

Code of Federal Regulations, 2014 CFR

2014-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.171 Off Delaware Bay: Eastern approach...

33 CFR 167.171 - Off Delaware Bay: Eastern approach.

Code of Federal Regulations, 2013 CFR

2013-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.171 Off Delaware Bay: Eastern approach...

33 CFR 167.171 - Off Delaware Bay: Eastern approach.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.171 Off Delaware Bay: Eastern approach...

33 CFR 167.174 - Off Delaware Bay: Precautionary area.

Code of Federal Regulations, 2014 CFR

2014-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.174 Off Delaware Bay: Precautionary area...

Connecting onshore and offshore near-surface geology: Delaware's sand inventory project

USGS Publications Warehouse

Ramsey, K.W.; Jordan, R.R.; Talley, J.H.

1999-01-01

Beginning in 1988, the Delaware Geological Survey began a program to inventory on-land sand resources suitable for beach nourishment. The inventory included an assessment of the native beach textures using existing data and developing parameters of what would be considered suitable sand textures for Delaware's Atlantic beaches. An assessment of the economics of on-land sand resources was also conducted, and it was determined that the cost of the sand was competitive with offshore dredging costs. In addition, the sand resources were put into a geologic context for purposes of predicting which depositional environments and lithostratigraphic units were most likely to produce suitable sand resources. The results of the work identified several suitable on-land sand resource areas in the Omar and Beaverdam formations that were deposited in barrier-tidal delta and fluvial-estuarine environments, respectively. The identified on-land resources areas have not been utilized due to difficulties of truck transport and development pressures in the resource areas. The Delaware Geological Survey's participation in years 8, 9, and 10 of the Continental Margins Program was developed to extend the known resource areas onshore to offshore Delaware in order to determine potential offshore sand resources for beach nourishment. Years 8 and 9 involved primarily the collection of all available data on the offshore geology. These data included all seismic lines, surface grab samples, and cores. The data were filtered for those that had reliable locations and geologic information that could be used for geologic investigations. Year 10 completed the investigations onshore by construction of a geologic cross-section from data along the coast of Delaware from Cape Henlopen to Fenwick. This cross section identified the geologic units and potential sand resource bodies as found immediately along the coast. These units and resources are currently being extended offshore and tied to known and potential sand resources as part of the continuing cooperative effort between the Delaware Geological Survey and the Minerals Management Service's INTERMAR office as sand resources are identified in federal waters off Delaware. Offshore sand resources are found in the Pliocene Beaverdam Formation offshore where overlying Quaternary units have been stripped, in the tidal delta complexes of several Quaternary units likely equivalent to the onshore Omar Formation, and in late Pleistocene- and Holocene-age shoal complexes. Onshore lithostratigraphic units can be traced offshore and show another reason for continued geologic mapping both onshore and offshore.The Delaware Geological Survey's participation in years 8, 9, and 10 of the Continental Margins Program was developed to extend the known resource areas onshore to offshore Delaware in order to determine potential offshore sand resources for beach nourishment. Years 8 and 9 involved primarily the collection of all available data on the offshore geology. These data included all seismic lines, surface grab samples, and cores. The data were filtered for those that had reliable locations and geologic information that could be used for geologic investigations. Year 10 completed the investigations onshore by construction of a geologic cross-section from data along the coast of Delaware from cape Henlopen to Fenwick.

Service quality of Early Childhood Education web portals in Finnish municipalities

NASA Astrophysics Data System (ADS)

Koskivaara, Eija; Pihlaja, Päivi

Increasing number of governmental organizations have transformed material on their web sites as a way of providing users with information about their products and services. In this paper, we apply Yang et al (2005) instrument for analyzing municipal early childhood education (ECE) web sites in Finland. The objective of the study was to find out the quality of ECE web portals as well as to give hints to improve their value from users' point of view. In general the five dimensions, usability, usefulness of content, adequacy of information, accessibility, and interaction, of the Yang et al model seems to be applicable also in the early childhood education environment.

Understanding the Scientific Basis of Electrocaloric Effect in Defects Modified Ferroelectric Polymers

DTIC Science & Technology

2014-12-19

0.2), but is higher than that of BZT(x=0.25). The directly recorded ECE signal from BZT(x=0.2) (at 35 oC under a E = 9.5 MVm -1) is presented in Fig...the sample as the field is removed are presented in Fig. 7(b) for the BZT(x=0.2) at 35 oC under different E. The data reveals that at E = 14 MVm -1...samples in the ECE study, the highest field that can be applied was 14 MVm -1. To make a comparison with the results on BT thick films, we extrapolate the

DOE Office of Scientific and Technical Information (OSTI.GOV)

The ECE application forecasts annual costs of preventive and corrective maintenance for budgeting purposes. Features within the application enable the user to change the specifications of the model to customize your forecast to best fit their needs and support “what if” analysis. Based on the user's selections, the ECE model forecasts annual maintenance costs. Preventive maintenance costs include the cost of labor to perform preventive maintenance activities at the specific frequency and labor rate. Corrective maintenance costs include the cost of labor and the cost of replacement parts. The application presents forecasted maintenance costs for the next five years inmore » two tables: costs by year and costs by site.« less

The excess choice effect: The role of outcome valence and counterfactual thinking.

PubMed

Hafner, Rebecca J; White, Mathew P; Handley, Simon J

2016-02-01

Contrary to economic theory, psychological research has demonstrated increased choice can undermine satisfaction. When and why this 'excess choice effect' (ECE) occurs remains unclear. Building on theories of counterfactual thinking we argue the ECE is more likely to occur when people experience counterfactual thought or emotion and that a key trigger is a negative versus positive task outcome. Participants either selected a drink (Experiment 1) or chocolate (Experiment 2) from a limited (6) versus extensive (24) selection (Experiment 1) or were given no choice versus extensive (24) choice (Experiment 2). In both experiments, however, the choice was illusory: Half the participants tasted a 'good' flavour, half a 'bad' flavour. As predicted, extensive choice was only detrimental to satisfaction when participants tasted the 'bad' drink or chocolate, and this was mediated by the experience of counterfactual thought (Experiment 1) or emotion (Experiment 2). When outcomes were positive, participants were similarly satisfied with limited versus extensive and no choice versus extensive choice. Implications for our theoretical understanding of the ECE and for the construction of choice architectures aimed at promoting individual satisfaction and well-being are discussed. © 2015 The British Psychological Society.

Understanding the Thermodynamic Properties of the Elastocaloric Effect Through Experimentation and Modelling

NASA Astrophysics Data System (ADS)

Tušek, Jaka; Engelbrecht, Kurt; Mañosa, Lluis; Vives, Eduard; Pryds, Nini

2016-12-01

This paper presents direct and indirect methods for studying the elastocaloric effect (eCE) in shape memory materials and its comparison. The eCE can be characterized by the adiabatic temperature change or the isothermal entropy change (both as a function of applied stress/strain). To get these quantities, the evaluation of the eCE can be done using either direct methods, where one measures (adiabatic) temperature changes or indirect methods where one can measure the stress-strain-temperature characteristics of the materials and from these deduce the adiabatic temperature and isothermal entropy changes. The former can be done using the basic thermodynamic relations, i.e. Maxwell relation and Clausius-Clapeyron equation. This paper further presents basic thermodynamic properties of shape memory materials, such as the adiabatic temperature change, isothermal entropy change and total entropy-temperature diagrams (all as a function of temperature and applied stress/strain) of two groups of materials (Ni-Ti and Cu-Zn-Al alloys) obtained using indirect methods through phenomenological modelling and Maxwell relation. In the last part of the paper, the basic definition of the efficiency of the elastocaloric thermodynamic cycle (coefficient of performance) is defined and discussed.

Comparison of Inboard-Outboard Pedestal Temperature Measurements in JET Using ECE Diagnostics

NASA Astrophysics Data System (ADS)

Barrera, L.; de la Luna, E.; Figini, L.

2008-03-01

Despite considerable effort, both theoretically and experimentally, a complete physical model to describe the particle and energy losses during ELMs is far from complete. On the experimental front, improved description of the spatial structure (poloidal asymmetry, radial distribution) and the dynamics of the ELM crash is a key requirement to answer some of the basic outstanding questions concerning the physics of ELMs. A significant number of diagnostics is now capable of fast measurements of the pedestal profile during an ELM, however, there is a lack of data from the inboard midplane, so assumptions of poloidal symmetry on the flux surfaces have often to be made. The aim of this work is to explore the capabilities of the electron cyclotron emission (ECE) diagnostics to provide simultaneous measurements of the edge temperature for both inboard and outboard plasma midplane. Access to the inboard region of the plasma is achieved in JET by using 1 harmonic/O-mode polarization, as it is not affected by harmonic overlap with the 2nd harmonic. This paper focuses on the validation of the inboard ECE data and the identification of the limitations of the measurements and the data analysis.

Electrochemical etching technique of platinum-iridium tips for scanning tunneling microscopy

NASA Astrophysics Data System (ADS)

Herrera, Oscar

The scanning tunneling microscope (STM) allows researchers to investigate atomic and molecular structures and properties of nanomaterials. Through the quantum tunneling effect a charge is transferred between the surface of the material and a Platinum-Iridium (Pt-Ir) tip. The production of Pt-Ir tips by electrochemical etching (ECE) has been developed as an alternative technique, to achieve enhanced scanned images of samples, in contrast to the standard mechanical method (SMM). The sharpness apex structure is an essential feature during scanning in order to provide reliable data. We generated a control group of tips by the SMM technique and another group by the ECE technique to investigate the resolution effectiveness in scanning of graphite. The etching of the tips was produced using an auto-variable transformer running a 30 V AC in a 1.5 and 4.0 M CaCl2 solution. The scanning of the graphite surface was conducted at 7x7 nm image width, 0.2 seconds time/line, 256 points/line and 0.05 V for tip voltage. ECE etched tips displayed consistent image resolution, and the sharpness of the tip apex was generally uniform.

Delaware traffic calming design manual

DOT National Transportation Integrated Search

2000-09-10

The Delaware Traffic Calming Manual consists of roadway design standards that are intended to encourage closer adherence to posted speeds, discourage cut-through traffic, enhance vehicular and pedestrian safety and community aesthetics. Its purpose i...

3. ELEVATION. FROM SOUTH WITH CANAL PRISM. Canal Road ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. ELEVATION. FROM SOUTH WITH CANAL PRISM. - Canal Road Bridge, Canal Road spanning Delaware Canal Diversion, Locks 22 & 23 in Delaware Canal State Park in Williams Township, Raubsville, Northampton County, PA

77 FR 69603 - Notice of Commission Meeting and Public Hearing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-20

... development of a Delaware Estuary Regional Sediment Management Plan. Items for Public Hearing. The subjects of... Commission on the development and use of a Delaware Estuary Eutrophication Model; (b) a resolution...

33 CFR 167.173 - Off Delaware Bay: Two-Way Traffic Route.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.173 Off Delaware Bay: Two-Way Traffic...

75 FR 22610 - Pennsylvania; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

..., Dauphin, Delaware, Fayette, Franklin, Fulton, Greene, Huntingdon, Indiana, Juniata, Lancaster, Lebanon..., Greene, Huntingdon, Indiana, Juniata, Lancaster, Lebanon, Perry, Philadelphia, Somerset, Westmoreland..., Dauphin, Delaware, Fayette, Franklin, Fulton, Greene, Huntingdon, Indiana, Juniata, Lancaster, Lebanon...

33 CFR 167.173 - Off Delaware Bay: Two-Way Traffic Route.

Code of Federal Regulations, 2012 CFR

2012-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.173 Off Delaware Bay: Two-Way Traffic...

33 CFR 167.173 - Off Delaware Bay: Two-Way Traffic Route.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.173 Off Delaware Bay: Two-Way Traffic...

33 CFR 167.173 - Off Delaware Bay: Two-Way Traffic Route.

Code of Federal Regulations, 2013 CFR

2013-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.173 Off Delaware Bay: Two-Way Traffic...

33 CFR 167.173 - Off Delaware Bay: Two-Way Traffic Route.

Code of Federal Regulations, 2014 CFR

2014-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.173 Off Delaware Bay: Two-Way Traffic...

Delaware's transportation agenda in the northeast corridor.

DOT National Transportation Integrated Search

2009-10-01

The fractionated governance structure of the entire Northeast Corridor (Warren 2009) is also : evidenced within the Baltimore-to-Philadelphia portion, which contains the entire extent of : Delawares claim to the corridor. Though comprising only a ...

8. DETAIL OF NOTCHED CONSTRUCTION ELEMENT IN GRILLAGE AT WESTERN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. DETAIL OF NOTCHED CONSTRUCTION ELEMENT IN GRILLAGE AT WESTERN EDGE OF SOUTHEASTERN LEG OF SEA WALL. TIDE APPROACHING. - Fort Delaware, Sea Wall, Pea Patch Island, Delaware City, New Castle County, DE

78 FR 48609 - Drawbridge Operation Regulation; Delaware River, NJ; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... townships of Tacony, PA and Palmyra, NJ. The deviation cited incorrect vertical clearances in the navigable... the Delaware River, mile 107.2, between the townships of Tacony, PA and Palmyra, NJ. The deviation...

Comparing models of Red Knot population dynamics

USGS Publications Warehouse

McGowan, Conor P.

2015-01-01

Predictive population modeling contributes to our basic scientific understanding of population dynamics, but can also inform management decisions by evaluating alternative actions in virtual environments. Quantitative models mathematically reflect scientific hypotheses about how a system functions. In Delaware Bay, mid-Atlantic Coast, USA, to more effectively manage horseshoe crab (Limulus polyphemus) harvests and protect Red Knot (Calidris canutus rufa) populations, models are used to compare harvest actions and predict the impacts on crab and knot populations. Management has been chiefly driven by the core hypothesis that horseshoe crab egg abundance governs the survival and reproduction of migrating Red Knots that stopover in the Bay during spring migration. However, recently, hypotheses proposing that knot dynamics are governed by cyclical lemming dynamics garnered some support in data analyses. In this paper, I present alternative models of Red Knot population dynamics to reflect alternative hypotheses. Using 2 models with different lemming population cycle lengths and 2 models with different horseshoe crab effects, I project the knot population into the future under environmental stochasticity and parametric uncertainty with each model. I then compare each model's predictions to 10 yr of population monitoring from Delaware Bay. Using Bayes' theorem and model weight updating, models can accrue weight or support for one or another hypothesis of population dynamics. With 4 models of Red Knot population dynamics and only 10 yr of data, no hypothesis clearly predicted population count data better than another. The collapsed lemming cycle model performed best, accruing ~35% of the model weight, followed closely by the horseshoe crab egg abundance model, which accrued ~30% of the weight. The models that predicted no decline or stable populations (i.e. the 4-yr lemming cycle model and the weak horseshoe crab effect model) were the most weakly supported.

Report of the River Master of the Delaware River for the period December 1, 1985, to November 30, 1986

USGS Publications Warehouse

Sauer, S.P.; Harkness, W.E.; Krejmas, B.E.; Vogel, K.L.

1987-01-01

A Decree of the Supreme Court of the United States in 1954 established the position of Delaware River Master. The Decree authorizes diversions of water from the Delaware River Basin (Figure 1) and requires compensating releases from certain reservoirs of the City of New York to be made under the supervision and direction of the River Master. Reports to the Court, not less frequently than annually, were stipulated. During the 1986 report year, December 1, 1985, to November 30, 1986, precipitation and runoff varied from below average to above average in the Delaware River Basin. For the year as a whole, precipitation was 4.3 inches above average. Runoff was near average. Operations were under a status of drought at the beginning of the report year. The drought emergency was terminated on December 18, 1985, by the Delaware River Basin Commission, and operations were returned to normal as prescribed by the Decree for the remainder of the report yr. Storage in the reservoirs increased to capacity during the winter months and all New York City Delaware River Basin reservoirs spilled throughout the year. Diversions from Delaware River Basin by New York City and New Jersey did not exceed those authorized by the terms of the Amended Decree. Releases were made as directed by the River Master at rates designed to meet the Montague flow objective on 69 days during the June to November period. Releases were made at conservation rates or at rates designed to relieve thermal stress in the streams downstream from the reservoirs at other times. The excess release quantity as defined by the Decree was not expended by end of the report year. New York City complied fully with the terms of the Decree and with the directives of the River Master during the year. (See also W89-04133) (USGS)

1. Photocopy of photograph. ORIGINAL CANAL COAL POCKETS Source: Delaware ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of photograph. ORIGINAL CANAL COAL POCKETS Source: Delaware and Hudson Railroad and Canal, by Wayne County Historical Society. - Honesdale Coal Pockets, Main & Commercial Streets, between 700 & 800 blocks, Honesdale, Wayne County, PA

75 FR 65703 - Notice of Applications for Certificates of Public Convenience and Necessity and Foreign Air...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-26

... related operating authorities to Compass Airlines LLC, a Delaware Limited LiabilityCompany. Renee V... corporation to a Delaware limitedliability company bearing the name Compass Airlines, LLC, and immediately...

Active adult (55+) community trip generation rates.

DOT National Transportation Integrated Search

2006-01-01

In response to the growing number of applications for the development of age restricted : communities (55 years old and older) the Delaware Department of Transportation (DelDOT) : through the Delaware Center for Transportation sponsored this study to...

11. NORTH VIEW OF INNER FACING OF SOUTHEASTERN LEG OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. NORTH VIEW OF INNER FACING OF SOUTHEASTERN LEG OF SEA WALL. SOUTHERN END OF NORTHEASTERN LEG OF SEA WALL IN BACKGROUND. - Fort Delaware, Sea Wall, Pea Patch Island, Delaware City, New Castle County, DE

Delaware Valley Regional Planning Commission Philadelphia Metropolitan Region : planning for congestion

DOT National Transportation Integrated Search

2009-04-01

The Delaware Valley Regional Planning Commission uses a systematic process for managing traffic congestion and monitoring transportation system performance in the Philadelphia metropolitan region. Guided by an advisory team of stakeholders, the agenc...

14. 1862 LITHOGRAPH SHOWING ST. DAVID'S CHURCH IN WINTER SCENE. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. 1862 LITHOGRAPH SHOWING ST. DAVID'S CHURCH IN WINTER SCENE. Photocopied from George Smith's book, History of Delaware County, Penna., 1862 - St. David's Church (Episcopal), Valley Forge Road (Newtown Township), Wayne, Delaware County, PA

Transportation elements assessment : Town of Milton, September 15, 2009.

DOT National Transportation Integrated Search

2009-09-15

During the summer of 2009, the Delaware T2 Center collected extensive data and completed analyses related to transportation infrastructure in the Town of Milton, Delaware. This report presents those data, the analyses, and resulting recommendations.