75 FR 66679 - Defense Federal Acquisition Regulation Supplement; Continuation of Current Contracts-Deletion of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-29

... Acquisition Regulation Supplement; Continuation of Current Contracts--Deletion of Redundant Text (DFARS Case... Supplement (DFARS) to delete redundant text relating to the continuation of current contracts with a... Case 2002-010 (68 FR 69250) incorporated these restrictions into the FAR. The DFARS text, therefore...

Medicare depreciation; useful life guidelines--HCFA. Proposed rule.

PubMed

1982-09-30

We are proposing to amend Medicare regulations to clarify which useful life guidelines providers of health care services may use to determine the useful life of a depreciable asset for Medicare reimbursement purposes. Current regulations state that providers must utilize HHS useful life guidelines or, if none have been published by HHS, the American Hospital Association (AHA) useful life guidelines of 1973 or IRS guidelines. We are proposing to eliminate the reference to IRS guidelines because those previously acceptable for Medicare purposes are outdated and have been made obsolete by the IRS or by statutory change. We would also delete the specific reference to the 1973 AHA guidelines. In addition, we intend this amendment to clarify that certain tax legislation on accelerated depreciation, recently passed by Congress, does not apply to the Medicare program.

76 FR 39951 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-07

... Proposed Rule Change Deleting the Text of NYSE Rule 409(f) and Adopting the Text of FINRA Rule 2232 and... of the Terms of Substance of the Proposed Rule Change The Exchange proposes (1) To delete the text of NYSE Rule 409(f) and adopt the text of FINRA Rule 2232 and (2) delete the Rule Interpretations to NYSE...

77 FR 40133 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing of Rule Change, as...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... Obsolete Text and To Clarify and Update the Description of The Allocation of Market and Limit Interest in... Allocation of Orders in Closing Transactions, and (4) Making Other Technical and Conforming Changes June 29... description of the allocation of market and limit interest in opening and reopening transactions, (3) amend...

76 FR 23911 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Reef Fish Fishery of the Gulf of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

... maintenance window for the Gulf individual fishing quota (IFQ) programs, and removing obsolete codified text..., etc.), extends the IFQ maintenance window an additional 8 hours to allow for more time to conduct end... maintenance window. All electronic IFQ transactions must be completed by December 31 at 6 p.m. eastern time...

Medicare program; Medicare depreciation, useful life guidelines--HCFA. Final rule.

PubMed

1983-08-18

These final rules amend Medicare regulations to clarify which useful life guidelines may be used by providers of health care services to determine the useful life of a depreciable asset for Medicare reimbursement purposes. Current regulations state that providers must utilize the Departmental useful life guidelines or, if none have been published by the Department, either the American Hospital Association (AHA) useful life guidelines of 1973 of IRS guidelines. We are eliminating the reference to IRS guidelines because these are now outdated for Medicare purposes since they have been rendered obsolete either by the IRS or by statutory change. We are also deleting the specific reference to the 1973 AHA guidelines since these guidelines are updated by the AHA periodically. In addition, we are clarifying that certain tax legislation on accelerated depreciation, passed by Congress, does not apply to the Medicare program.

37 CFR 1.125 - Substitute specification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... text of any deleted matter must be shown by strike-through except that double brackets placed before.... The text of any deleted subject matter must be shown by being placed within double brackets if strike...

76 FR 39949 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-07

... Deleting the Text of Rule 409(f)--NYSE Amex Equities and Adopting the Text of FINRA Rule 2232 June 30, 2011... proposes to delete the text of Rule 409(f)--NYSE Amex Equities and adopt the text of FINRA Rule 2232. The text of the proposed rule change is available at the Exchange, the Commission's Public Reference Room...

78 FR 10226 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

... Proposed Rule Change To Cease Operating New York Block Exchange and Contemporaneously Delete the Text of... of the Proposed Rule Change The Exchange proposes to contemporaneously delete the text of Rule 1600, which governs NYBX functionality. The text of the proposed rule change is available on the Exchange's...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Potash, Peter J.; Bell, Eric B.; Harrison, Joshua J.

Predictive models for tweet deletion have been a relatively unexplored area of Twitter-related computational research. We first approach the deletion of tweets as a spam detection problem, applying a small set of handcrafted features to improve upon the current state-of-the- art in predicting deleted tweets. Next, we apply our approach to a dataset of deleted tweets that better reflects the current deletion rate. Since tweets are deleted for reasons beyond just the presence of spam, we apply topic modeling and text embeddings in order to capture the semantic content of tweets that can lead to tweet deletion. Our goal ismore » to create an effective model that has a low-dimensional feature space and is also language-independent. A lean model would be computationally advantageous processing high-volumes of Twitter data, which can reach 9,885 tweets per second. Our results show that a small set of spam-related features combined with word topics and character-level text embeddings provide the best f1 when trained with a random forest model. The highest precision of the deleted tweet class is achieved by a modification of paragraph2vec to capture author identity.« less

76 FR 53015 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-24

... Proposed Rule Change Deleting the Text of NYSE Rule 92 and Adopting a New NYSE Rule 5320 That Is... Terms of Substance of the Proposed Rule Change The Exchange proposes to delete the text of NYSE Rule 92... same as Financial Industry Regulatory Authority (``FINRA'') Rule 5320. The text of the proposed rule...

76 FR 64154 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

... Proposed Rule Change Deleting NYSE Rules 132A, 132B, and 132C, Adopting the Text of the FINRA Rule 7400... Exchange proposes to delete NYSE Rules 132A, 132B, and 132C, adopt the text of the FINRA Rule 7400 Series, the Order Audit Trail System (``OATS'') Rules, and make certain conforming changes. The text of the...

76 FR 53012 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-24

... Change Deleting the Text of NYSE Arca Equities Rules 6.16 and 6.16A, and Adopting New NYSE Arca Equities... Change The Exchange proposes to delete the text of NYSE Arca Equities Rules 6.16 and 6.16A, which limit... substantially the same as Financial Industry Regulatory Authority (``FINRA'') Rule 5320. The text of the...

75 FR 16001 - New Animal Drugs; Removal of Obsolete and Redundant Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-31

... drug-resistant bacteria associated with these animals, was obsolete as FDA had a new strategy and... antimicrobials in animal feed, with regard to their microbiological effects on bacteria of human health concern...

34 CFR 395.6 - Vendor ownership of vending facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... facility in good repair and in an attractive condition and replace worn-out or obsolete equipment; and if... facility in good repair and in an attractive condition and replace worn-out or obsolete equipment, or...

34 CFR 395.6 - Vendor ownership of vending facilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... facility in good repair and in an attractive condition and replace worn-out or obsolete equipment; and if... facility in good repair and in an attractive condition and replace worn-out or obsolete equipment, or...

9 CFR 355.36 - Obsolete labels.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Obsolete labels. 355.36 Section 355.36 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION, AND...

9 CFR 355.36 - Obsolete labels.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Obsolete labels. 355.36 Section 355.36 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION CERTIFIED PRODUCTS FOR DOGS, CATS, AND OTHER CARNIVORA; INSPECTION, CERTIFICATION, AND...

76 FR 15901 - Acquisition Regulation Miscellaneous Changes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... obsolete material is being removed. DATES: Submit comments by May 23, 2011. ADDRESSES: You may submit... order to update references to other federal and Departmental directives, remove obsolete material and... efficient and transparent. This rule will not adversely affect in a material way the economy, productivity...

75 FR 17857 - Removal of Obsolete References to Herbicides Containing Dioxin

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... Herbicides Containing Dioxin AGENCY: Department of Veterans Affairs. ACTION: Final rule. SUMMARY: The... health effects of exposure to herbicides containing dioxin and radiation to remove the obsolete references to herbicides containing dioxin. This final rule reflects changes made by the Agent Orange Act of...

26 CFR 301.6110-3 - Deletion of certain information in written determinations open to public inspection.

Code of Federal Regulations, 2010 CFR

2010-04-01

... determinations open to public inspection. 301.6110-3 Section 301.6110-3 Internal Revenue INTERNAL REVENUE SERVICE... open to public inspection. (a) Information subject to deletion. There shall be deleted from the text of any written determination open to public inspection or subject to inspection upon written request and...

91. VIEW OF OBSOLETE AIRCONDITIONING DUCTS LOCATED IN NORTHWEST CORNER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

91. VIEW OF OBSOLETE AIR-CONDITIONING DUCTS LOCATED IN NORTHWEST CORNER OF ROOM, ABOVE SLC-3E AUTOPILOT EQUIPMENT. DIGITAL COUNTDOWN AND HOLD CLOCKS ON WALL LEFT OF DUCTS - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Is Progressive Education Obsolete: A Reconsideration.

ERIC Educational Resources Information Center

Beineke, John A.

1993-01-01

Van Til's 1962 article on whether or not progressive education is obsolete was a response to charges that the new education as espoused by Dewey was outmoded. This paper reexamines Van Til's article and suggests a prognostication similar to Van Til's could be ventured today that another period of progressivism is inevitable. (SM)

76 FR 27606 - Technical Corrections To Remove Obsolete References to Non-Automated Carriers From Electronic...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

...] Technical Corrections To Remove Obsolete References to Non- Automated Carriers From Electronic Cargo... manifests for vessels transporting bulk and certain break bulk cargo to the United States to make several... transmit cargo declaration information electronically (non-automated carriers). When CBP amended its...

Next Generation Satellite Communications: Automated Doppler Shift Compensation of PSK-31 Via Software-Defined Radio

DTIC Science & Technology

2014-05-09

Interfaces Configuration – Wired Network Connections before Editing Move the cursor to the end of the line that ends with “eth0 inet dhcp ” and type...X”. This will delete text one character back from the cursor. Delete the word “ dhcp ”. Once this is done, type “a” to begin inserting text and add

Optical Laser Technology, Specifically CD-ROM (Compact Disc - Read Only Memory) and Its Application to the Storage and Retrieval of Information.

DTIC Science & Technology

1987-06-01

RESOLUTION TEST CHART NATIONAL BUREAU OF STANDARIS-1963-A gT~ ILE CE NAVAL POSTGRADUATE SCHOOL Monterey, California ;.CTE THESIS uEOIB OPTICAL LASER... usedin it xr~awsd SECURITY CLASSIFICATION Of ’-IS5 PACTF All other edtoni are obsolete 0’ NC TA? 7RI UNCLASSIFIED S3CUNTY CLASSIFICATION OF THIS PA69 (WhI...where the resulting mixture of text, color graphics, animation , and audio can be achieved. This technology is in the formative stages, however it is

Is CALL Obsolete? Language Acquisition and Language Learning Revisited in a Digital Age

ERIC Educational Resources Information Center

Jarvis, Huw; Krashen, Stephen

2014-01-01

In this article, Huw Jarvis and Stephen Krashen ask "Is CALL Obsolete?" When the term CALL (Computer-Assisted Language Learning) was introduced in the 1960s, the language education profession knew only about language learning, not language acquisition, and assumed the computer's primary contribution to second language acquisition…

75 FR 81685 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-28

... confusing or duplicative language and unnecessary references to terms or systems that are now obsolete. The... confusing or duplicative language and unnecessary references to terms or systems that are now obsolete. By... designed to modernize and strengthen the national market system for equities and replace the outdated...

77 FR 60619 - Removal of Obsolete Regulation: Use of the Centennial of Flight Commission Name

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-04

... Removal of Obsolete Regulation: Use of the Centennial of Flight Commission Name AGENCY: National... section 1204. 506 entitled ``Delegation of Authority to License the Use of the Centennial of Flight Commission Name.'' Section 506, Delegation of Authority to License the Use of the Centennial of Flight...

27. DIABLO POWERHOUSE UPPER OIL ROOM: OBSOLETE WESTINGHOUSE DIELECTRIC OIL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. DIABLO POWERHOUSE UPPER OIL ROOM: OBSOLETE WESTINGHOUSE DIELECTRIC OIL TESTING SET. OIL IS USED AS AN INSULATOR IN TRANSFORMERS AND ITS CONDUCTIVITY USED TO BE TESTED USING EQUIPMENT SUCH AS THIS, 1989. - Skagit Power Development, Diablo Powerhouse, On Skagit River, 6.1 miles upstream from Newhalem, Newhalem, Whatcom County, WA

Reduce, Reuse, Recycle: Good Earth and the Electronics Dilemma

ERIC Educational Resources Information Center

Descy, Don E.

2007-01-01

According to the National Safety Council, 63 million computers became obsolete in 2005 alone, and it is estimated that the total number in storage in 2007 numbers upwards of 500 million computers (Earth 911, 2007). This article describes the steps that one should take before disposing of an obsolete computer. First and foremost, all personal…

Addressing Counterfeit Parts in the DoD Supply Chain

DTIC Science & Technology

2014-03-01

components are genuine, given this industry’s relatively quick innovation cycles. Many active military systems were built using now-obsolete...reviews, and other activities that can delay acquisitions and increase acquisition costs. The QSLD program also enables the DSCC to use automated...case of semiconductors, many active military systems were built using now-obsolete semiconductors, the production of which was halted years, even

77 FR 28423 - Final Rule To Implement the 1997 8-Hour Ozone National Ambient Air Quality Standard...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-14

...The EPA is revising the rules for implementing the 1997 8-hour ozone national ambient air quality standards (NAAQS) to address certain limited portions of the rules vacated by the U.S. Court of Appeals for the District of Columbia Circuit. This final rule assigns Clean Air Act (CAA or Act) classifications and associated state planning and control requirements to selected ozone nonattainment areas. This final rule also addresses three vacated provisions of the 1997 8-hour NAAQS--Phase 1 Implementation Rule (April 30, 2004) that provided exemptions from the anti-backsliding requirements relating to nonattainment area New Source Review (NSR), CAA section 185 penalty fees, and contingency measures, as these three requirements applied for the 1-hour standard. This rule also reinstates the 1-hour contingency measures as applicable requirements that must be retained until the area attains the 1997 8- hour ozone standard. Finally, this rule deletes an obsolete provision that stayed the EPA's authority to revoke the 1-hour ozone standard pending the Agency's issuance of a final rule that revises or reinstates its revocation authority and considers and addresses certain other issues. That rule has now been issued.

Future trends in computer waste generation in India.

PubMed

Dwivedy, Maheshwar; Mittal, R K

2010-11-01

The objective of this paper is to estimate the future projection of computer waste in India and to subsequently analyze their flow at the end of their useful phase. For this purpose, the study utilizes the logistic model-based approach proposed by Yang and Williams to forecast future trends in computer waste. The model estimates future projection of computer penetration rate utilizing their first lifespan distribution and historical sales data. A bounding analysis on the future carrying capacity was simulated using the three parameter logistic curve. The observed obsolete generation quantities from the extrapolated penetration rates are then used to model the disposal phase. The results of the bounding analysis indicate that in the year 2020, around 41-152 million units of computers will become obsolete. The obsolete computer generation quantities are then used to estimate the End-of-Life outflows by utilizing a time-series multiple lifespan model. Even a conservative estimate of the future recycling capacity of PCs will reach upwards of 30 million units during 2025. Apparently, more than 150 million units could be potentially recycled in the upper bound case. However, considering significant future investment in the e-waste recycling sector from all stakeholders in India, we propose a logistic growth in the recycling rate and estimate the requirement of recycling capacity between 60 and 400 million units for the lower and upper bound case during 2025. Finally, we compare the future obsolete PC generation amount of the US and India. Copyright © 2010 Elsevier Ltd. All rights reserved.

78 FR 28218 - Sunshine Act Meeting; Deletion of Agenda Item From May 9, 2013 Open Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... TITLE: Facilitating HOMELAND the Deployment of SECURITY. Text-to-911 and Other Next Generation 911... Commission will consider a Report and Order requiring CMRS providers and providers of interconnected text... text 911 where that capability is unavailable. Federal Communications Commission. Marlene H. Dortch...

The Effects of Elaboration on Self-Learning Procedures from Text.

ERIC Educational Resources Information Center

Yang, Fu-mei

This study investigated the effects of augmenting and deleting elaborations in an existing self-instructional text for a micro-computer database application, "Microsoft Works User's Manual." A total of 60 undergraduate students were randomly assigned to the original, elaborated, or unelaborated text versions. The elaborated version…

76 FR 9616 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-18

... Delete the Text of Rule 1500, Which Governs MatchPoint's Functionality February 11, 2011. Pursuant to... the text of Rule 1500, which governs MatchPoint's functionality. The text of the proposed rule change... the proposed rule change. The text of those statements may be examined at the places specified in Item...

76 FR 53072 - Certification; Importation of Vehicles and Equipment Subject to Federal Safety, Bumper, and Theft...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-25

... used as a basis for the non-automatic suspension of an RI registration, deletes redundant text from... Part 592 as a Basis for the Non-Automatic Suspension or Revocation of an RI Registration B. Deletion of... violations of the regulations in part 592 as a basis for the non-automatic suspension or revocation of an RI...

47 CFR 1.229 - Motions to enlarge, change, or delete issues.

Code of Federal Regulations, 2013 CFR

2013-10-01

... forfeiture of up to the maximum statutory amount. See 47 U.S.C. 503(b)(2)(A). [41 FR 14872, Apr. 8, 1976, as... 47 Telecommunication 1 2013-10-01 2013-10-01 false Motions to enlarge, change, or delete issues. 1... for in paragraph (b) of this section, such motions must be filed within 15 days after the full text or...

47 CFR 1.229 - Motions to enlarge, change, or delete issues.

Code of Federal Regulations, 2014 CFR

2014-10-01

... forfeiture of up to the maximum statutory amount. See 47 U.S.C. 503(b)(2)(A). [41 FR 14872, Apr. 8, 1976, as... 47 Telecommunication 1 2014-10-01 2014-10-01 false Motions to enlarge, change, or delete issues. 1... for in paragraph (b) of this section, such motions must be filed within 15 days after the full text or...

47 CFR 1.229 - Motions to enlarge, change, or delete issues.

Code of Federal Regulations, 2012 CFR

2012-10-01

... for a forfeiture of up to the maximum statutory amount. See 47 U.S.C. 503(b)(2)(A). [41 FR 14872, Apr... 47 Telecommunication 1 2012-10-01 2012-10-01 false Motions to enlarge, change, or delete issues. 1... for in paragraph (b) of this section, such motions must be filed within 15 days after the full text or...

Decommissioning Handbook

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-03-01

The Decommissioning Handbook is a technical guide for the decommissioning of nuclear facilities. The decommissioning of a nuclear facility involves the removal of the radioactive and, for practical reasons, hazardous materials to enable the facility to be released and not represent a further risk to human health and the environment. This handbook identifies and technologies and techniques that will accomplish these objectives. The emphasis in this handbook is on characterization; waste treatment; decontamination; dismantling, segmenting, demolition; and remote technologies. Other aspects that are discussed in some detail include the regulations governing decommissioning, worker and environmental protection, and packaging and transportationmore » of the waste materials. The handbook describes in general terms the overall decommissioning project, including planning, cost estimating, and operating practices that would ease preparation of the Decommissioning Plan and the decommissioning itself. The reader is referred to other documents for more detailed information. This Decommissioning Handbook has been prepared by Enserch Environmental Corporation for the US Department of Energy and is a complete restructuring of the original handbook developed in 1980 by Nuclear Energy Services. The significant changes between the two documents are the addition of current and the deletion of obsolete technologies and the addition of chapters on project planning and the Decommissioning Plan, regulatory requirements, characterization, remote technology, and packaging and transportation of the waste materials.« less

New orthopaedic implant management tool for computer-assisted planning, navigation, and simulation: from implant CAD files to a standardized XML-based implant database.

PubMed

Sagbo, S; Blochaou, F; Langlotz, F; Vangenot, C; Nolte, L-P; Zheng, G

2005-01-01

Computer-Assisted Orthopaedic Surgery (CAOS) has made much progress over the last 10 years. Navigation systems have been recognized as important tools that help surgeons, and various such systems have been developed. A disadvantage of these systems is that they use non-standard formalisms and techniques. As a result, there are no standard concepts for implant and tool management or data formats to store information for use in 3D planning and navigation. We addressed these limitations and developed a practical and generic solution that offers benefits for surgeons, implant manufacturers, and CAS application developers. We developed a virtual implant database containing geometrical as well as calibration information for orthopedic implants and instruments, with a focus on trauma. This database has been successfully tested for various applications in the client/server mode. The implant information is not static, however, because manufacturers periodically revise their implants, resulting in the deletion of some implants and the introduction of new ones. Tracking these continuous changes and keeping CAS systems up to date is a tedious task if done manually. This leads to additional costs for system development, and some errors are inevitably generated due to the huge amount of information that has to be processed. To ease management with respect to implant life cycle, we developed a tool to assist end-users (surgeons, hospitals, CAS system providers, and implant manufacturers) in managing their implants. Our system can be used for pre-operative planning and intra-operative navigation, and also for any surgical simulation involving orthopedic implants. Currently, this tool allows addition of new implants, modification of existing ones, deletion of obsolete implants, export of a given implant, and also creation of backups. Our implant management system has been successfully tested in the laboratory with very promising results. It makes it possible to fill the current gap that exists between the CAS system and implant manufacturers, hospitals, and surgeons.

Study on status quo of shipbreaking sector and strategies

NASA Astrophysics Data System (ADS)

Shen, Wei; Xing, Guojing

2017-11-01

In recent years, the quantity of broken obsolete vessels tends to rise year by year in the shipbreaking sector, but breaking down obsolete vessels is one of vessel operations with high pollution and high risk, involving proper disposal of hazardous substances, bulge discarded oils and other materials, and thus causing great danger and harm. In this paper the author investigates mainly the status quo of the shipbreaking sector, comes up with the “green-shipbreaking” concept, analyzes main problems currently present in the shipbreaking sector and presents proper strategies and recommendations to deal with them.

77 FR 56902 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

... Proposed Rule Change To Delete Non-Operable Text Within Its Price List Applicable to Supplemental Liquidity... non-operable text within its Price List applicable to Supplemental Liquidity Providers (``SLPs''). The text of the proposed rule change is available on the Exchange's Web site at www.nyse.com , at the...

77 FR 10791 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-23

... Deleting NYSE Amex Equities Rule 319, Which Addresses Fidelity Bond Requirements, and Adopt New Rule Text... 319, which addresses fidelity bond requirements, and adopt new rule text that is substantially similar to FINRA Rule 4360. The text of the proposed rule change is available at the Exchange, the Commission...

Boyer-Moore Algorithm in Retrieving Deleted Short Message Service in Android Platform

NASA Astrophysics Data System (ADS)

Rahmat, R. F.; Prayoga, D. F.; Gunawan, D.; Sitompul, O. S.

2018-02-01

Short message service (SMS) can be used as digital evidence of disclosure of crime because it can strengthen the charges against the offenders. Criminals use various ways to destroy the evidence, including by deleting SMS. On the Android OS, SMS is stored in a SQLite database file. Deletion of SMS data is not followed by bit deletion in memory so that it is possible to rediscover the deleted SMS. Based on this case, the mobile forensic needs to be done to rediscover the short message service. The proposed method in this study is Boyer-Moore algorithm for searching string matching. An auto finds feature is designed to rediscover the short message service by searching using a particular pattern to rematch a text with the result of the hex value conversion in the database file. The system will redisplay the message for each of a match. From all the testing results, the proposed method has quite a high accuracy in rediscovering the short message service using the used dataset. The search results to rediscover the deleted SMS depend on the possibility of overwriting process and the vacuum procedure on the database file.

Automap User’s Guide 2013

DTIC Science & Technology

2013-06-03

dairyFarm.txt Ted runs a dairy farm. He milks the cows , runs the office, and cleans the barn. 136 dairyFarmDeleteList.txt There are some...applying the delete list, the text appears in the display like this: Ted runs dairy farm. He milks cows , runs office, cleans ...in the file. dairyFarmMeta.csv Ted,agent runs,task dairy,resource farm,location He,agent milks ,task cows ,resource office,location cleans

Role of single-point mutations and deletions on transition temperatures in ideal proteinogenic heteropolymer chains in the gas phase.

PubMed

Olivares-Quiroz, L

2016-07-01

A coarse-grained statistical mechanics-based model for ideal heteropolymer proteinogenic chains of non-interacting residues is presented in terms of the size K of the chain and the set of helical propensities [Formula: see text] associated with each residue j along the chain. For this model, we provide an algorithm to compute the degeneracy tensor [Formula: see text] associated with energy level [Formula: see text] where [Formula: see text] is the number of residues with a native contact in a given conformation. From these results, we calculate the equilibrium partition function [Formula: see text] and characteristic temperature [Formula: see text] at which a transition from a low to a high entropy states is observed. The formalism is applied to analyze the effect on characteristic temperatures [Formula: see text] of single-point mutations and deletions of specific amino acids [Formula: see text] along the chain. Two probe systems are considered. First, we address the case of a random heteropolymer of size K and given helical propensities [Formula: see text] on a conformational phase space. Second, we focus our attention to a particular set of neuropentapeptides, [Met-5] and [Leu-5] enkephalins whose thermodynamic stability is a key feature on their coupling to [Formula: see text] and [Formula: see text] receptors and the triggering of biochemical responses.

76 FR 39947 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-07

... Deleting NYSE Amex Equities Rule 351(a)-(d) and Supplementary Material .10 and .13, Adopting the Text of... NYSE Amex Equities Rule 351(a)-(d) and Supplementary Material .10 and .13, adopt the text of FINRA Rule 4530, and make certain conforming changes. The text of the proposed rule change is available at the...

76 FR 53009 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-24

... Deleting the Text of NYSE Amex Equities Rules 92, 513, 514 and Adopting New NYSE Amex Equities Rule 5320... the text of NYSE Amex Equities Rules 92, 513, and 514, which limit trading ahead of customer orders... Regulatory Authority (``FINRA'') Rule 5320. The text of the proposed rule change is available at the Exchange...

76 FR 64151 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

... Deleting NYSE Amex Equities Rules 132A, 132B, and 132C, Adopting the Text of the FINRA Rule 7400 Series... Equities Rules 132A, 132B, and 132C, adopt the text of the FINRA Rule 7400 Series, the Order Audit Trail System (``OATS'') Rules, and make certain conforming changes. The text of the proposed rule change is...

77 FR 6613 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-08

... Change Deleting the Text of NYSE Arca Equities Rule 5.2(b)(1) and Adopting New NYSE Arca Equities Rule... the text of NYSE Arca Equities Rule 5.2(b)(1) and adopt new NYSE Arca Equities Rule 5190 that is substantially the same as Financial Industry Regulatory Authority (``FINRA'') Rule 5190. The text of the...

75 FR 53347 - Cooperative Agreements Under the Disability Employment Initiative; Solicitation for Grant...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

... amendment is to correct language related to the number of points for Project Management to be consistent.... Delete the following text: 4. Project Management (10 points) Add the following text: Project Management... follows: 4. This amendment is to correct language related to the number of points for Project Management...

77 FR 45392 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-31

... Deleting Existing Rule Text Found in Rule 923NY(d)(1) to (4) Concerning the Number of ATP's Required by an... rule text found in Rule 923NY(d)(1) to (4) concerning the number of ATP's required by an NYSE Amex Options Market Maker to quote on the Exchange and move it to the Fee Schedule. The text of the proposed...

Digitally recycled incubators: better economic alternatives to modern systems in low-income countries.

PubMed

Amadi, H O; Mokuolu, O A; Adimora, G N; Pam, S D; Etawo, U S; Ohadugha, C O; Adesiyun, O O

2007-09-01

The need to maintain a neutral thermal environment is critical to newborn care. To investigate reasons for the insufficiency of functional incubators and develop a cost-effective technique for using electronic digital components to recycle obsolete incubators in Nigeria. Following interview of 84 clinicians and administrators in Nigerian hospitals, it was identified that inadequate funding was the main reason for lack of functional incubators. Two groups of incubator units were then created and their performance compared. Sixteen units of modern (group A) and 19 units of obsolete (group B) incubators were obtained from six hospitals. An assembly design applying independent generic components for recycling systems was specified and produced. These were sourced through the internet at competitive cost and fitted into the reconstructed panels of the obsolete systems. The functional performance of each recycled system was rigorously monitored for 6 months and graded using ten performance indices. The same indices were used to quantify group A systems. The performance of the recycled incubators (group B) was found to be similar to those of modern incubators. Group B's cost index was found to be 25% of that of group A's. Appropriate incubator recycling is a cost-effective method of re-equipping hospitals in low-income countries.

Adaptive removal of background and white space from document images using seam categorization

NASA Astrophysics Data System (ADS)

Fillion, Claude; Fan, Zhigang; Monga, Vishal

2011-03-01

Document images are obtained regularly by rasterization of document content and as scans of printed documents. Resizing via background and white space removal is often desired for better consumption of these images, whether on displays or in print. While white space and background are easy to identify in images, existing methods such as naïve removal and content aware resizing (seam carving) each have limitations that can lead to undesirable artifacts, such as uneven spacing between lines of text or poor arrangement of content. An adaptive method based on image content is hence needed. In this paper we propose an adaptive method to intelligently remove white space and background content from document images. Document images are different from pictorial images in structure. They typically contain objects (text letters, pictures and graphics) separated by uniform background, which include both white paper space and other uniform color background. Pixels in uniform background regions are excellent candidates for deletion if resizing is required, as they introduce less change in document content and style, compared with deletion of object pixels. We propose a background deletion method that exploits both local and global context. The method aims to retain the document structural information and image quality.

DOE Office of Scientific and Technical Information (OSTI.GOV)

"rsed" is an R package that contains tools for stream editing: manipulating text files by making insertions, replacements, deletions, substitutions, or commenting. It hails from the powerful Unix command, "sed". While the "rsed" package is not nearly as powerful as "see", it is much simpler to use. R programmers often write scripts that may require simple manipulation of text files. "rsed" addresses that need.

The Measurement of the Perception of Cohesion: A Second Language Example.

ERIC Educational Resources Information Center

Anderson, Jonathan

Within the framework of a general model of communication, a model of language communication has been developed and applied to the perception of cohesion. To measure students' perception of textual cohesion, a pilot study in the United Kingdom built "noise" into texts by deleting parts of each texts. Subjects, 59 nonremedial students whose first…

Tangible Things of American Astronomy

NASA Astrophysics Data System (ADS)

Schechner, Sara Jane

2018-01-01

As a science that studies celestial objects situated at vast distances from us, astronomy deals with few things that can be touched directly. And yet, astronomy has many tangible things—scientific instruments, observatories, and log books, for example—which link the past to the present. There is little question about maintaining things still valuable for scientific research purposes, but why should we care about documenting and preserving the old and obsolete? One answer is that material things, when closely examined, enhance our knowledge of astronomy’s history in ways that written texts alone cannot do. A second answer is that learning about the past helps us live critically in the present. In brief case studies, this talk will find meaning in objects that are extraordinary or commonplace. These will include a sundial, an almanac, telescopes, clocks, a rotating desk, photographic plates, and fly spankers.

24 CFR 905.10 - Capital Fund formula (CFF).

Code of Federal Regulations, 2013 CFR

2013-04-01

... projects; (ii) Vacancy reduction; (iii) Addressing deferred maintenance needs and the replacement of obsolete utility systems and dwelling equipment; (iv) Planned code compliance; (v) Management improvements...

24 CFR 905.10 - Capital Fund formula (CFF).

Code of Federal Regulations, 2012 CFR

2012-04-01

... projects; (ii) Vacancy reduction; (iii) Addressing deferred maintenance needs and the replacement of obsolete utility systems and dwelling equipment; (iv) Planned code compliance; (v) Management improvements...

77 FR 10351 - Regulatory Review Plan

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-22

... regulation inefficient, obsolete, contrary to controlling legal precedent, or unduly burdensome; (2... what steps may be necessary to relieve any unnecessary burden, including amendment to or repeal of...

Transition to an Aquatic Habitat Permitted the Repeated Loss of the Pleiotropic KLK8 Gene in Mammals

PubMed Central

Hecker, Nikolai; Sharma, Virag

2017-01-01

Abstract Kallikrein related peptidase 8 (KLK8; also called neuropsin) is a serine protease that plays distinct roles in the skin and hippocampus. In the skin, KLK8 influences keratinocyte proliferation and desquamation, and activates antimicrobial peptides in sweat. In the hippocampus, KLK8 affects memory acquisition. Here, we examined the evolution of KLK8 in mammals and discovered that, out of 70 placental mammals, KLK8 is exclusively lost in three independent fully-aquatic lineages, comprising dolphin, killer whale, minke whale, and manatee. In addition, while the sperm whale has an intact KLK8 reading frame, the gene evolves neutrally in this species. We suggest that the distinct functions of KLK8 likely became obsolete in the aquatic environment, leading to the subsequent loss of KLK8 in several fully-aquatic mammalian lineages. First, the cetacean and manatee skin lacks sweat glands as an adaptation to the aquatic environment, which likely made the epidermal function of KLK8 obsolete. Second, cetaceans and manatees exhibit a proportionally small hippocampus, which may have rendered the hippocampal functions of KLK8 obsolete. Together, our results shed light on the genomic changes that correlate with skin and neuroanatomical differences of aquatic mammals, and show that even pleiotropic genes can be lost during evolution if an environmental change nullifies the need for the different functions of such genes. PMID:29145610

Organochlorine pesticides in surface soils from obsolete pesticide dumping ground in Hyderabad City, Pakistan: contamination levels and their potential for air-soil exchange.

PubMed

Alamdar, Ambreen; Syed, Jabir Hussain; Malik, Riffat Naseem; Katsoyiannis, Athanasios; Liu, Junwen; Li, Jun; Zhang, Gan; Jones, Kevin C

2014-02-01

This study was conducted to examine organochlorine pesticides (OCPs) contamination levels in the surface soil and air samples together with air-soil exchange fluxes at an obsolete pesticide dumping ground and the associated areas from Hyderabad City, Pakistan. Among all the sampling sites, concentrations of OCPs in the soil and air samples were found highest in obsolete pesticide dumping ground, whereas dominant contaminants were dichlorodiphenyltrichloroethane (DDTs) (soil: 77-212,200 ng g(-1); air: 90,700 pg m(-3)) and hexachlorocyclohexane (HCHs) (soil: 43-4,090 ng g(-1); air: 97,400 pg m(-3)) followed by chlordane, heptachlor and hexachlorobenzene (HCB). OCPs diagnostic indicative ratios reflect historical use as well as fresh input in the study area. Moreover, the air and soil fugacity ratios (0.9-1.0) at the dumping ground reflecting a tendency towards net volatilization of OCPs, while at the other sampling sites, the fugacity ratios indicate in some cases deposition and in other cases volatilization. Elevated concentrations of DDTs and HCHs at pesticide dumping ground and its surroundings pose potential exposure risk to biological organisms, to the safety of agricultural products and to the human health. Our study thus emphasizes the need of spatio-temporal monitoring of OCPs at local and regional scale to assess and remediate the future adverse implications. © 2013.

Regenerative Medicine Will Make Orthopaedic Implants Obsolete In Our Time Orthopaedic Research Society First Annual Meeting Debate, San Diego, March 21st , 2017.

PubMed

Johnstone, Brian; Jacobs, Joshua J; Sandell, Linda J; Wilkinson, J Mark

2018-05-10

The mission of the Orthopaedic Research Society is to promote and advance musculoskeletal research worldwide. With this in mind, the Annual Meeting Program Committee sought to establish a debate as a key component of the meeting. Our purpose was to provoke discussion on topics that are core to our mission and to engage all constituencies within the society by examining questions of broad relevance. To this end, the topic "Regenerative medicine will make orthopaedic implants obsolete in our time" was selected as the title of the inaugural debate. The arguments for and against the motion are presented in this perspectives article. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

77 FR 65941 - Energy Conservation Program: Test Procedures for Residential Dishwashers, Dehumidifiers, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-31

...The U.S. Department of Energy (DOE) establishes new test procedures for residential dishwashers and dehumidifiers, and amends the currently applicable test procedure for conventional cooking products under the Energy Policy and Conservation Act. The new test procedures include provisions for measuring standby mode and off mode energy consumption, and update the provisions for measuring active mode energy consumption and, for dishwashers, water consumption. This final rule also amends the certification, compliance, and enforcement requirements for dishwashers, dehumidifiers and conventional cooking products, amends certain provisions in the currently applicable dishwasher test procedure, and eliminates an obsolete energy efficiency metric in the dishwasher test procedure and provisions in the cooking products test procedure that have become obsolete due to the elimination of standing pilot lights.

Text Comprehension in Chinese Children: Relative Contribution of Verbal Working Memory, Pseudoword Reading, Rapid Automated Naming, and Onset-Rime Phonological Segmentation

ERIC Educational Resources Information Center

Leong, Che Kan; Tse, Shek Kam; Loh, Ka Yee; Hau, Kit Tai

2008-01-01

The present study examined the role of verbal working memory (memory span, tongue twister), 2-character Chinese pseudoword reading, rapid automatized naming (letters, numbers), and phonological segmentation (deletion of rimes and onsets) in inferential text comprehension in Chinese in 518 Chinese children in Hong Kong in Grades 3 to 5. It was…

For Spacious Skies: A New Look at Planets.

ERIC Educational Resources Information Center

Geoghegan, Jane P.

1984-01-01

The information explosion on the solar system has made old notions about space obsolete. This article offers information about the planets and suggests classroom activities and teacher resources. (DF)

RNA Interference in the Age of CRISPR: Will CRISPR Interfere with RNAi?

PubMed Central

Unniyampurath, Unnikrishnan; Pilankatta, Rajendra; Krishnan, Manoj N.

2016-01-01

The recent emergence of multiple technologies for modifying gene structure has revolutionized mammalian biomedical research and enhanced the promises of gene therapy. Over the past decade, RNA interference (RNAi) based technologies widely dominated various research applications involving experimental modulation of gene expression at the post-transcriptional level. Recently, a new gene editing technology, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and the CRISPR-associated protein 9 (Cas9) (CRISPR/Cas9) system, has received unprecedented acceptance in the scientific community for a variety of genetic applications. Unlike RNAi, the CRISPR/Cas9 system is bestowed with the ability to introduce heritable precision insertions and deletions in the eukaryotic genome. The combination of popularity and superior capabilities of CRISPR/Cas9 system raises the possibility that this technology may occupy the roles currently served by RNAi and may even make RNAi obsolete. We performed a comparative analysis of the technical aspects and applications of the CRISPR/Cas9 system and RNAi in mammalian systems, with the purpose of charting out a predictive picture on whether the CRISPR/Cas9 system will eclipse the existence and future of RNAi. The conclusion drawn from this analysis is that RNAi will still occupy specific domains of biomedical research and clinical applications, under the current state of development of these technologies. However, further improvements in CRISPR/Cas9 based technology may ultimately enable it to dominate RNAi in the long term. PMID:26927085

RNA Interference in the Age of CRISPR: Will CRISPR Interfere with RNAi?

PubMed

Unniyampurath, Unnikrishnan; Pilankatta, Rajendra; Krishnan, Manoj N

2016-02-26

The recent emergence of multiple technologies for modifying gene structure has revolutionized mammalian biomedical research and enhanced the promises of gene therapy. Over the past decade, RNA interference (RNAi) based technologies widely dominated various research applications involving experimental modulation of gene expression at the post-transcriptional level. Recently, a new gene editing technology, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and the CRISPR-associated protein 9 (Cas9) (CRISPR/Cas9) system, has received unprecedented acceptance in the scientific community for a variety of genetic applications. Unlike RNAi, the CRISPR/Cas9 system is bestowed with the ability to introduce heritable precision insertions and deletions in the eukaryotic genome. The combination of popularity and superior capabilities of CRISPR/Cas9 system raises the possibility that this technology may occupy the roles currently served by RNAi and may even make RNAi obsolete. We performed a comparative analysis of the technical aspects and applications of the CRISPR/Cas9 system and RNAi in mammalian systems, with the purpose of charting out a predictive picture on whether the CRISPR/Cas9 system will eclipse the existence and future of RNAi. The conclusion drawn from this analysis is that RNAi will still occupy specific domains of biomedical research and clinical applications, under the current state of development of these technologies. However, further improvements in CRISPR/Cas9 based technology may ultimately enable it to dominate RNAi in the long term.

System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice.

PubMed

Mesci, Pinar; Zaïdi, Sakina; Lobsiger, Christian S; Millecamps, Stéphanie; Escartin, Carole; Seilhean, Danielle; Sato, Hideyo; Mallat, Michel; Boillée, Séverine

2015-01-01

Amyotrophic lateral sclerosis is the most common adult-onset motor neuron disease and evidence from mice expressing amyotrophic lateral sclerosis-causing SOD1 mutations suggest that neurodegeneration is a non-cell autonomous process where microglial cells influence disease progression. However, microglial-derived neurotoxic factors still remain largely unidentified in amyotrophic lateral sclerosis. With excitotoxicity being a major mechanism proposed to cause motor neuron death in amyotrophic lateral sclerosis, our hypothesis was that excessive glutamate release by activated microglia through their system [Formula: see text] (a cystine/glutamate antiporter with the specific subunit xCT/Slc7a11) could contribute to neurodegeneration. Here we show that xCT expression is enriched in microglia compared to total mouse spinal cord and absent from motor neurons. Activated microglia induced xCT expression and during disease, xCT levels were increased in both spinal cord and isolated microglia from mutant SOD1 amyotrophic lateral sclerosis mice. Expression of xCT was also detectable in spinal cord post-mortem tissues of patients with amyotrophic lateral sclerosis and correlated with increased inflammation. Genetic deletion of xCT in mice demonstrated that activated microglia released glutamate mainly through system [Formula: see text]. Interestingly, xCT deletion also led to decreased production of specific microglial pro-inflammatory/neurotoxic factors including nitric oxide, TNFa and IL6, whereas expression of anti-inflammatory/neuroprotective markers such as Ym1/Chil3 were increased, indicating that xCT regulates microglial functions. In amyotrophic lateral sclerosis mice, xCT deletion surprisingly led to earlier symptom onset but, importantly, this was followed by a significantly slowed progressive disease phase, which resulted in more surviving motor neurons. These results are consistent with a deleterious contribution of microglial-derived glutamate during symptomatic disease. Therefore, we show that system [Formula: see text] participates in microglial reactivity and modulates amyotrophic lateral sclerosis motor neuron degeneration, revealing system [Formula: see text] inactivation, as a potential approach to slow amyotrophic lateral sclerosis disease progression after onset of clinical symptoms. © The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Are Manual Typewriters Becoming Obsolete?

ERIC Educational Resources Information Center

Johnston, Jean

1976-01-01

A University of Akron survey of the Akron area revealed that the general trend is for large companies to use manual typewriters in their business offices. Implications for typewriting instruction are discussed. (JT)

Improving bridge load rating accuracy.

DOT National Transportation Integrated Search

2013-06-01

Nearly one-quarter of Alabamas bridges are deemed structurally deficient or functionally obsolete. An : additional seven percent of Alabamas bridges were posted bridges in 2010. (Federal Highway Administration, : 2011) Accurate bridge load rati...

Ideas To Save Electricity

ERIC Educational Resources Information Center

Gardner, John C.

1974-01-01

Significant energy savings can be effected through stopping obvious waste of water, electricity, and heat; purchasing equipment with the correct voltage and horsepower; equipment maintenance; and redesigning or replacing obsolete or inefficient equipment. (Author/MF)

7 CFR 1955.63 - Suitability determination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... found in § 1955.53. (b) Grouping and subdividing farm properties. To the maximum extent practicable, the... which is obsolete due to location, design, construction or age. (5) A dwelling which requires major...

2002 Construction manual

DOT National Transportation Integrated Search

2002-01-01

The Illinois Department of Transportation's Highway Construction Manual has been updated from its previous version. All previous editions of this manual are now obsolete and changes in content have been marked. The Construction Manual provides inform...

Cerebrospinal Fluid Shunting Complications in Children

PubMed Central

Hanak, Brian W.; Bonow, Robert H.; Harris, Carolyn A.; Browd, Samuel R.

2018-01-01

Although cerebrospinal fluid (CSF) shunt placement is the most common procedure performed by pediatric neurosurgeons, shunts remain among the most failure-prone life-sustaining medical devices implanted in modern medical practice. This article provides an overview of the mechanisms of CSF shunt failure for the 3 most commonly employed definitive CSF shunts in the practice of pediatric neurosurgery: ventriculoperitoneal, ventriculopleural, and ventriculoatrial. The text has been partitioned into the broad modes of shunt failure: obstruction, infection, mechanical shunt failure, overdrainage, and distal catheter site-specific failures. Clinical management strategies for the various modes of shunt failure are discussed as are research efforts directed towards reducing shunt complication rates. As it is unlikely that CSF shunting will become an obsolete procedure in the foreseeable future, it is incumbent on the pediatric neurosurgery community to maintain focused efforts to improve our understanding of and management strategies for shunt failure and shunt-related morbidity. PMID:28249297

76 FR 41794 - Notice of Agreements Filed

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-15

...- Gesellschaft KG; King Ocean Services Limited; and King Ocean Service de Venezuela, S.A. Filing Party: Wayne... obsolete language, corrects the address of Hamburg Sud, and removes King Ocean Service de Venezuela, S.A...

21 CFR 211.122 - Materials examination and usage criteria.

Code of Federal Regulations, 2011 CFR

2011-04-01

... differentiated by size, shape, or color. (g) If cut labeling is used, packaging and labeling operations shall.... (e) Obsolete and outdated labels, labeling, and other packaging materials shall be destroyed. (f) Use...

Establishing benchmarks and metrics for disruptive technologies, inappropriate and obsolete tests in the clinical laboratory.

PubMed

Kiechle, Frederick L; Arcenas, Rodney C; Rogers, Linda C

2014-01-01

Benchmarks and metrics related to laboratory test utilization are based on evidence-based medical literature that may suffer from a positive publication bias. Guidelines are only as good as the data reviewed to create them. Disruptive technologies require time for appropriate use to be established before utilization review will be meaningful. Metrics include monitoring the use of obsolete tests and the inappropriate use of lab tests. Test utilization by clients in a hospital outreach program can be used to monitor the impact of new clients on lab workload. A multi-disciplinary laboratory utilization committee is the most effective tool for modifying bad habits, and reviewing and approving new tests for the lab formulary or by sending them out to a reference lab. Copyright © 2013 Elsevier B.V. All rights reserved.

Transition to an Aquatic Habitat Permitted the Repeated Loss of the Pleiotropic KLK8 Gene in Mammals.

PubMed

Hecker, Nikolai; Sharma, Virag; Hiller, Michael

2017-11-01

Kallikrein related peptidase 8 (KLK8; also called neuropsin) is a serine protease that plays distinct roles in the skin and hippocampus. In the skin, KLK8 influences keratinocyte proliferation and desquamation, and activates antimicrobial peptides in sweat. In the hippocampus, KLK8 affects memory acquisition. Here, we examined the evolution of KLK8 in mammals and discovered that, out of 70 placental mammals, KLK8 is exclusively lost in three independent fully-aquatic lineages, comprising dolphin, killer whale, minke whale, and manatee. In addition, while the sperm whale has an intact KLK8 reading frame, the gene evolves neutrally in this species. We suggest that the distinct functions of KLK8 likely became obsolete in the aquatic environment, leading to the subsequent loss of KLK8 in several fully-aquatic mammalian lineages. First, the cetacean and manatee skin lacks sweat glands as an adaptation to the aquatic environment, which likely made the epidermal function of KLK8 obsolete. Second, cetaceans and manatees exhibit a proportionally small hippocampus, which may have rendered the hippocampal functions of KLK8 obsolete. Together, our results shed light on the genomic changes that correlate with skin and neuroanatomical differences of aquatic mammals, and show that even pleiotropic genes can be lost during evolution if an environmental change nullifies the need for the different functions of such genes. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Resumes de texte en langue maternelle et en langue seconde: Differences dans l'application des macroregles entre experts et etudiants de differents niveaux universitaires (Test Summaries in the Mother Tongue and in a Second Language: Differences in the Application of Macrorules between Experts and University Students of Various Levels).

ERIC Educational Resources Information Center

Corbeil, Giselle

2001-01-01

Analyzes differences between experts and university students of various academic levels in the application of the macrorules of deletion, generalization, and construction of text summaries. Learners of French as a second language wrote summaries of a French text in French as well as in English, their mother tongue, while professors of French and…

78 FR 6331 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

...--New); Frequency: Occasionally; Affected Public: Private Sector. Number of Respondents: 4,900. Number... competitiveness. Each agency was directed to establish an ongoing plan to reduce or eliminate burdensome, obsolete...

Social Networking: It's Not What You Think

NASA Technical Reports Server (NTRS)

Jones, Kevin D.

2010-01-01

This slide presentation reviews some of the current uses of the social networking sites available on the internet. It list some of the skills that are now considered obsolete and reviews the major social networking sites.

Developing county bridge repair and retrofit techniques.

DOT National Transportation Integrated Search

2013-08-01

Oklahoma rated first in the Nation in the percentage of bridges that are structurally deficient or : functionally obsolete. According to Federal Highway Administration data, Oklahoma uses : approximately 23,250 bridges maintained by state, County, Ci...

High Flyers: Glorious Past, Gloomy Present, Any Future?

ERIC Educational Resources Information Center

Baruch, Yehuda; Peiperl, Maury

1997-01-01

New types of psychological contracts, in which promotions cannot be guaranteed or expected, are emerging. Former methods of selecting and assessing high-potential candidates are obsolete, and human resource management practices must change. (SK)

Development of a structural health monitoring (SHM) guidebook for critical bridge structures.

DOT National Transportation Integrated Search

2013-07-01

A recently completed study suggests that approximately 25% of them are either structurally deficient : or functionally obsolete (FHWA, 2007). Therefore, the Federal Highway Administration (FHWA) : and the Oklahoma Transportation Center (OTC) have mad...

Debt Financing: Academia's Funding Alternative.

ERIC Educational Resources Information Center

Baum, Rudy M.

1981-01-01

Discusses debt financing as a way to help universities alleviate the problems of obsolete scientific equipment and facilities for research. Reviews several forms of tax-exempt financing and takes note of some of the advantages of debt financing. (CS)

Soundoff: Mathematics Is Getting Easier.

ERIC Educational Resources Information Center

Usiskin, Zalman

1984-01-01

Teaching mathematics in hard ways, rather than using easier methods or technology, is described. Employing the most efficient means possible to solve a problem is the essence of good mathematics, rather than wasting time in practicing obsolete skills. (MNS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. E. Lawson, R. Marsala, S. Ramakrishnan, X. Zhao, P. Sichta

In order to provide improved and expanded experimental capabilities, the existing Transrex power supplies at PPPL are to be upgraded and modernized. Each of the 39 power supplies consists of two six pulse silicon controlled rectifier sections forming a twelve pulse power supply. The first modification is to split each supply into two independent six pulse supplies by replacing the existing obsolete twelve pulse firing generator with two commercially available six pulse firing generators. The second change replaces the existing control link with a faster system, with greater capacity, which will allow for independent control of all 78 power supplymore » sections. The third change replaces the existing Computer Automated Measurement and Control (CAMAC) based fault detector with an Experimental Physics and Industrial Control System (EPICS) compatible unit, eliminating the obsolete CAMAC modules. Finally the remaining relay logic and interfaces to the "Hardwired Control System" will be replaces with a Programmable Logic Controller (PLC).« less

Rapid breeding and varietal replacement are critical to adaptation of cropping systems in the developing world to climate change.

PubMed

Atlin, Gary N; Cairns, Jill E; Das, Biswanath

2017-03-01

Plant breeding is a key mechanism for adaptation of cropping systems to climate change. Much discussion of breeding for climate change focuses on genes with large effects on heat and drought tolerance, but phenology and stress tolerance are highly polygenic. Adaptation will therefore mainly result from continually adjusting allele frequencies at many loci through rapid-cycle breeding that delivers a steady stream of incrementally improved cultivars. This will require access to elite germplasm from other regions, shortened breeding cycles, and multi-location testing systems that adequately sample the target population of environments. The objective of breeding and seed systems serving smallholder farmers should be to ensure that they use varieties developed in the last 10 years. Rapid varietal turnover must be supported by active dissemination of new varieties, and active withdrawal of obsolete ones. Commercial seed systems in temperate regions achieve this through competitive seed markets, but in the developing world, most crops are not served by competitive commercial seed systems, and many varieties date from the end of the Green Revolution (the late 1970s, when the second generation of modern rice and wheat varieties had been widely adopted). These obsolete varieties were developed in a climate different than today's, placing farmers at risk. To reduce this risk, a strengthened breeding system is needed, with freer international exchange of elite varieties, short breeding cycles, high selection intensity, wide-scale phenotyping, and accurate selection supported by genomic technology. Governments need to incentivize varietal release and dissemination systems to continuously replace obsolete varieties.

Recycled Cell Phones - A Treasure Trove of Valuable Metals

USGS Publications Warehouse

Sullivan, Daniel E.

2006-01-01

This U.S. Geological Survey (USGS) Fact Sheet examines the potential value of recycling the metals found in obsolete cell phones. Cell phones seem ubiquitous in the United States and commonplace throughout most of the world. There were approximately 1 billion cell phones in use worldwide in 2002. In the United States, the number of cell phone subscribers increased from 340,000 in 1985 to 180 million in 2004. Worldwide, cell phone sales have increased from slightly more than 100 million units per year in 1997 to an estimated 779 million units per year in 2005. Cell phone sales are projected to exceed 1 billion units per year in 2009, with an estimated 2.6 billion cell phones in use by the end of that year. The U.S. Environmental Protection Agency estimated that, by 2005, as many as 130 million cell phones would be retired annually in the United States. The nonprofit organization INFORM, Inc., anticipated that, by 2005, a total of 500 million obsolete cell phones would have accumulated in consumers' desk drawers, store rooms, or other storage, awaiting disposal. Typically, cell phones are used for only 1 1/2 years before being replaced. Less than 1 percent of the millions of cell phones retired and discarded annually are recycled. When large numbers of cell phones become obsolete, large quantities of valuable metals end up either in storage or in landfills. The amount of metals potentially recoverable would make a significant addition to total metals recovered from recycling in the United States and would supplement virgin metals derived from mining.

Economic impact of closing low-volume rural bridges.

DOT National Transportation Integrated Search

2013-02-01

The State of Kansas has approximately 25,464 bridges that are located on the state, county and : city roadway network. As the infrastructure in Kansas ages, bridges can become structurally : deficient or functionally obsolete. The Kansas Department o...

77 FR 37470 - Technical Standard Order (TSO)-C65a, Airborne Doppler Radar Ground Speed and/or Drift Angle...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-21

... inputs to semiautomatic self-contained dead reckoning navigation systems which were not continuously... Doppler sensor equipment that provides inputs to dead reckoning navigation systems obsolete. On August 18...

Parallel Algorithms for Groebner-Basis Reduction

DTIC Science & Technology

1987-09-25

22209 ELEMENT NO. NO. NO. ACCESSION NO. 11. TITLE (Include Security Classification) * PARALLEL ALGORITHMS FOR GROEBNER -BASIS REDUCTION 12. PERSONAL...All other editions are obsolete. Productivity Engineering in the UNIXt Environment p Parallel Algorithms for Groebner -Basis Reduction Technical Report

75 FR 77029 - Self-Regulatory Organizations; The NASDAQ OMX BX Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

... that are obsolete or generally limiting, given the evolution of technologies and systems through which... and manipulative acts and practices, to promote just and equitable principles of trade, to foster...

Bill Gates eyes healthcare market.

PubMed

Dunbar, C

1995-02-01

The entrepreneurial spirit is still top in Bill Gates' mind as he look toward healthcare and other growth industries. Microsoft's CEO has not intention of going the way of other large technology companies that became obsolete before they could compete today.

Moving beyond Transgression: Contextualizing Plagiarism and Patchwriting

ERIC Educational Resources Information Center

Crook, Stephanie

2016-01-01

This paper explores the phenomenon of "patchwriting," a term which Howard (1992) coined to refer to the practice of "copying from a source text and then deleting some words, altering grammatical structures, or plugging in one-for-one synonym substitutes" (p. 233). Although patchwriting in universities is often labeled simply as…

Moving freight in the new economy : payoffs, perils and paradoxes.

DOT National Transportation Integrated Search

2000-09-26

The infusion of information technology in all industrial processes has elevated the performance of the U.S. economy to new heights. Yet our transportation system is still guided by many of the obsolete infrastructure investment and pricing paradigms ...

78 FR 49697 - HUD Acquisition Regulations (HUDAR): Correcting Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-15

... final rule that amended the HUDAR to implement miscellaneous changes, which included, for example, removing obsolete and redundant provisions, updating provisions that address the organizational structure of HUD, and adding provisions on contractor record retention. In making the organizational changes...

Transverse joint configuration development and testing for a modular bridge deck replacement system.

DOT National Transportation Integrated Search

2011-03-01

According to the 2009 Report Card for Americas Infrastructure, one in four of the nations bridges are listed as : structurally deficient of functionally obsolete, establishing a dire need for new and innovative repair and replacement : techniqu...

Investigation of ownership and maintenance responsibilities for structures separating highway and railroad traffic.

DOT National Transportation Integrated Search

1998-05-01

One of the goals defined in Virginia Connections: Strategic Plan for Transportation is to "reduce or eliminate obsolete state laws governing transportation providers." In response to this goal, then Secretary of Transportation Robert Martinez establi...

76 FR 53057 - National Environmental Policy Act Procedures

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-25

... POSTAL SERVICE 39 CFR Part 775 National Environmental Policy Act Procedures AGENCY: Postal Service. ACTION: Final rule. SUMMARY: This rule amends the Postal Service's National Environmental Policy Act (NEPA) compliance procedures to update an obsolete statutory reference. DATES: Effective Date: August 25...

Low water stream crossings in Iowa : a selection and design guide.

DOT National Transportation Integrated Search

2003-02-01

Most Iowa counties maintain low volume roads with at least one bridge or culvert that is structurally : deficient or obsolete. In some counties the percentage of deficient drainage structures may be as : high as 62%. Replacement with structures of si...

Evaluation of bridge replacement alternatives for the county bridge system.

DOT National Transportation Integrated Search

1994-08-01

Recent reports have indicated that 23.5 percent of the nation's highway bridges are : structurally deficient and 17.7 percent are functionally obsolete. A significant number of these bridges : are on the Iowa county road system. The objective of the ...

48 CFR 1845.7101-1 - Property classification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... aeronautical and space programs, which are capable of stand-alone operation. Examples include research aircraft... characteristics. (ii) Examples of NASA heritage assets include buildings and structures designated as National...., it no longer provides service to NASA operations). Examples of obsolete property are items in...

48 CFR 1845.7101-1 - Property classification.

Code of Federal Regulations, 2011 CFR

2011-10-01

... aeronautical and space programs, which are capable of stand-alone operation. Examples include research aircraft... characteristics. (ii) Examples of NASA heritage assets include buildings and structures designated as National...., it no longer provides service to NASA operations). Examples of obsolete property are items in...

48 CFR 1845.7101-1 - Property classification.

Code of Federal Regulations, 2014 CFR

2014-10-01

... aeronautical and space programs, which are capable of stand-alone operation. Examples include research aircraft... characteristics. (ii) Examples of NASA heritage assets include buildings and structures designated as National...., it no longer provides service to NASA operations). Examples of obsolete property are items in...

48 CFR 1845.7101-1 - Property classification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... aeronautical and space programs, which are capable of stand-alone operation. Examples include research aircraft... characteristics. (ii) Examples of NASA heritage assets include buildings and structures designated as National...., it no longer provides service to NASA operations). Examples of obsolete property are items in...

48 CFR 1845.7101-1 - Property classification.

Code of Federal Regulations, 2012 CFR

2012-10-01

... aeronautical and space programs, which are capable of stand-alone operation. Examples include research aircraft... characteristics. (ii) Examples of NASA heritage assets include buildings and structures designated as National...., it no longer provides service to NASA operations). Examples of obsolete property are items in...

Finite element modeling approach and performance evaluation of fiber reinforced polymer sandwich bridge panels : summary.

DOT National Transportation Integrated Search

2009-08-01

In the United States, about 27% of the bridges are classified as structurally deficient or functionally obsolete. Bridge owners are continually investigating methods to effectively retrofit existing bridges, or to economically replace them with new o...

Small Town in Mass Society Revisited.

ERIC Educational Resources Information Center

Young, Frank W.

1996-01-01

A 1958 New York community study dramatized the thesis that macro forces (urbanization, industrialization, bureaucratization) have undermined all small communities' autonomy. Such "oppositional case studies" succeed when they render the dominant view immediately obsolete, have plausible origins, are testable, and generate new research.…

Finite element modeling approach and performance evaluation of fiber reinforced polymer sandwich bridge panels : final report.

DOT National Transportation Integrated Search

2009-08-01

In the United States, about 27% of the bridges are classified as structurally deficient or functionally obsolete. : Bridge owners are continually investigating methods to effectively retrofit existing bridges, or to economically replace : them with n...

Reverse Logistics

DTIC Science & Technology

2001-05-01

reverse logistics was to pick up the damage or obsolete items from the vendor and discard them into a land fill. Estee Lauder Companies, Inc. dumped as...Quality Center, Benchmarking and Leveraging “Best Practices” Strategies , Houston, TX, AQPC, 1995. 2. Brauner, Marygail, “Evaluating Five Proposed Price

Computer Education with "Retired" Industrial Systems.

ERIC Educational Resources Information Center

Nesin, Dan; And Others

1980-01-01

Describes a student-directed computer system revival project in the Electrical and Computer Engineering department at California State Polytechnic University, which originated when an obsolete computer was donated to the department. Discusses resulting effects in undergraduate course offerings, in student extracurricular activities, and in…

The Forum of the International HCH and Pesticides Association--a platform for international cooperation.

PubMed

Vijgen, John; Aliyeva, Gulchohra; Weber, Roland

2013-04-01

The unsustainable life cycle management of pesticides in the last 60 years has created large pesticide stockpiles. The two major working areas of the International HCH and Pesticide Association (IHPA; www.ihpa.info ) address a part of these legacies and are shortly introduced here: (1) The assessment and support of the management of the worlds single largest POPs stockpile: the globally dumped 4 to 7 million tonnes hexachlorocyclohexane (HCH) wastes from lindane production, and (2) the support for the management of the obsolete pesticides legacy in Eastern Europe, the Caucasus and Central Asia (EECCA) countries of ~240,000 t, leaving these pesticides in unregulated storages without adequate safety control being a huge risk to the environment and human health. The integrative approach IHPA takes-promoting international cooperation and the exchange of knowledge and experiences-is shortly explained. IHPA has developed various supporting tools for its work: the IHPA web page and newsletter informing on the threats and challenges, but also on the progresses of managing pesticide stockpiles; the joint GIZ-PAN-IHPA exhibition on awareness of the pesticide stockpile challenge; and the 'International HCH and Pesticides Forum' as most important tool to progress the integrative work and mission of IHPA. Finally, a summary of the 11th International HCH and Pesticides Forum held in Gabala, Azerbaijan is given which brought together more than 120 scientists, policy-makers, non-governmental and international organisations, industry and students from more than 40 countries to progress the obsolete pesticides and hazardous chemical waste challenge in EECCA countries. The event finished with adoption of 'Gabala Declaration', which aims to mobilise efforts of all stakeholders for prevention and elimination of POPs, obsolete pesticides, and hazardous chemical waste in the region.

Leaching of indium from obsolete liquid crystal displays: Comparing grinding with electrical disintegration in context of LCA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dodbiba, Gjergj, E-mail: dodbiba@sys.t.u-tokyo.ac.jp; Nagai, Hiroki; Wang Lipang

2012-10-15

Highlights: Black-Right-Pointing-Pointer Two pre-treatment methods, prior to leaching of indium from obsolete LCD modules, were described. Black-Right-Pointing-Pointer Conventional grinding and electrical disintegration have been evaluated and compared in the context of LCA. Black-Right-Pointing-Pointer Experimental data on the leaching capacity for indium and the electricity consumption of equipment were inputted into the LCA model in order to compare the environmental performance of each method. Black-Right-Pointing-Pointer An estimate for the environmental performance was calculated as the sum of six impact categories. Black-Right-Pointing-Pointer Electrical disintegration method outperforms conventional grinding in all impact categories. - Abstract: In order to develop an effective recycling systemmore » for obsolete Liquid Crystal Displays (LCDs), which would enable both the leaching of indium (In) and the recovery of a pure glass fraction for recycling, an effective liberation or size-reduction method would be an important pre-treatment step. Therefore, in this study, two different types of liberation methods: (1) conventional grinding, and (2) electrical disintegration have been tested and evaluated in the context of Life Cycle Assessment (LCA). In other words, the above-mentioned methods were compared in order to find out the one that ensures the highest leaching capacity for indium, as well as the lowest environmental burden. One of the main findings of this study was that the electrical disintegration was the most effective liberation method, since it fully liberated the indium containing-layer, ensuring a leaching capacity of 968.5 mg-In/kg-LCD. In turn, the estimate for the environmental burden was approximately five times smaller when compared with the conventional grinding.« less

The primary evaluation and characterization of obsolete DDT pesticide from a precalciner of a cement kiln.

PubMed

Li, Yang; Wang, Qi; Huang, Qifei; He, Jie

2014-01-01

1,1,1-Trichloro-2,2-bi(4-chlorophenyl)ethane (DDT) pesticide that has been extensively used in agriculture in China in the last century, and even now, has been banned from all purposes. The disposal of obsolete DDT pesticide has been an urgent task for the Chinese government. In order to evaluate the feasibility of co-processing DDT in the current new style dry-process rotary kiln with a precalciner as the feeding point, the destruction efficiency (DE) of DDTs (including p,p(')-DDT, o,p(')-DDT, p,p(')-DDE and p,p(')-DDD), proportion of DDTs in the combustion residue and exhaust gas, and the release of chlorine were studied under different operating conditions of temperature, oxygen content and gas retention time in the laboratory. The DE of DDTs exceeded 99% when the temperature was over 800 °C with enough oxygen. As the temperature increased from 600 °C to 1200 °C, the proportion of p,p(')-DDD increased and p,p(')-DDT decreased but still the main effective component remained in the combustion residue. In the exhaust gas, the most dominant phenomenon was the rapid increase in p,p(')-DDE concentration as the temperature increased. The release of chlorine reached a peak between 800 °C and 900 °C. It was found that the oxygen content had a positive correlation with the process of dechlorination. The proportion of p,p(')-DDE increased as the oxygen content was increased in the exhaust gas. The gas retention time had almost no influenced on the DE of DDTs, but affected the degradation extent of DDTs in the gas phase. These experiments showed that co-processing of obsolete DDT pesticide in cement kiln precalciners is feasible.

Infrastructure and equipment for radiation oncology in the Spanish National Health System: analysis of external beam radiotherapy 2015-2020.

PubMed

Rodríguez, A; Algara, M; Monge, D; López-Torrecilla, J; Caballero, F; Morera, R; Escó, R; Pérez-Montero, H; Ferrer, C; Lara, P C

2018-03-01

Planning for radiation oncology requires reliable estimates of both demand for radiotherapy and availability of technological resources. This study compares radiotherapy resources in the 17 regions of the decentralised Spanish National Health System (SNHS). The Sociedad Española de Oncología Radioterápica (SEOR) performed a cross-sectional survey of all Spanish radiation oncology services (ROS) in 2015. We collected data on SNHS radiotherapy units, recording the year of installation, specific features of linear accelerators (LINACs) and other treatment units, and radiotherapeutic techniques implemented by region. Any machine over 10 years old or lacking a multileaf collimator or portal imaging system was considered obsolete. We performed a k-means clustering analysis using the Hartigan-Wong method to test associations between the gross domestic regional product (GDRP), the number of LINACs per million population and the percentage of LINACs over 10 years old. The SNHS controls 72 (61%) of the 118 Spanish ROS and has 180 LINACs, or 72.5% of the total public and private resources. The mean rate of LINACs per million population is 3.9 for public ROS, and 42% (n = 75) of the public accelerators were obsolete in 2015: 61 due to age and 14 due to technological capability. There was considerable regional variation in terms of the number and technological capacity of radiotherapy units; correlation between GRDP and resource availability was moderate. Despite improvements, new investments are still needed to replace obsolete units and increase access to modern radiotherapy. Regular analysis of ROS in each Spanish region is the only strategy for monitoring progress in radiotherapy capacity.

With the Advent of Tomosynthesis in the Workup of Mammographic Abnormality, is Spot Compression Mammography Now Obsolete? An Initial Clinical Experience.

PubMed

Ni Mhuircheartaigh, Neasa; Coffey, Louise; Fleming, Hannah; O' Doherty, Ann; McNally, Sorcha

2017-09-01

To determine if the routine use of spot compression mammography is now obsolete in the assessment of screen detected masses, asymmetries and architectural distortion since the availability of digital breast tomosynthesis. We introduced breast tomosynthesis in the workup of screen detected abnormalities in our screening center in January 2015. During an initial learning period with tomosynthesis standard spot compression views were also performed. Three consultant breast radiologists retrospectively reviewed all screening mammograms recalled for assessment over the first 6-month period. We assessed retrospectively whether there was any additional diagnostic information obtained from spot compression views not already apparent on tomography. All cases were also reviewed for any additional lesions detected by tomosynthesis, not detected on routine 2-view screening mammography. 548 women screened with standard 2-view digital screening mammography were recalled for assessment in the selected period and a total of 565 lesions were assessed. 341 lesions were assessed by both tomosynthesis and routine spot compression mammography. The spot compression view was considered more helpful than tomosynthesis in only one patient. This was because the breast was inadequately positioned for tomosynthesis and the area in question was not adequately imaged. Apart from this technical error there was no asymmetry, distortion or mass where spot compression provided more diagnostic information than tomosynthesis alone. We detected three additional cancers on tomosynthesis, not detected by routine screening mammography. From our initial experience with tomosynthesis we conclude that spot compression mammography is now obsolete in the assessment of screen detected masses, asymmetries and distortions where tomosynthesis is available. © 2017 Wiley Periodicals, Inc.

Framing the Text: Using Storyboards to Engage Students with Reading

ERIC Educational Resources Information Center

Bruce, David L.

2011-01-01

Storyboards deliver a narrative through discrete visual representations. The purpose of the storyboards was always to "scaffold" the final product and students were free to add, delete, or adapt those images that were most helpful to their project. The storyboards served as a brainstorming activity, much like a prewriting exercise for a written…

76 FR 52373 - Self-Regulatory Organizations; Chicago Mercantile Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

... Change To Adopt a New Rule Regarding Liens on Collateral That Relates Solely to Its Futures Clearing...; bracketed text indicates deletions. * * * * * Rule 819. [Reserved] Lien on Collateral. Each Clearing Member hereby grants to the Clearing House a first priority and unencumbered lien, as security for all...

The Deceptive Mean: Conceptual Scoring of Cloze Entries Differentially Advantages More Able Readers

ERIC Educational Resources Information Center

O'Toole, J. M.; King, R. A. R.

2011-01-01

The "cloze" test is one possible investigative instrument for predicting text comprehensibility. Conceptual coding of student replacement of deleted words has been considered to be more valid than exact coding, partly because conceptual coding seemed fairer to poorer readers. This paper reports a quantitative study of 447 Australian…

Cognitive Clozing To Teach Them To Think.

ERIC Educational Resources Information Center

Viaggio, Sergio

A cloze-type procedure can be used effectively to teach interpreters how to anticipate what the speaker will say, inferring communicative intention. The exercise uses a text from which words are deleted, not randomly as in the true cloze procedure, but in significant locations or contexts. The words or groups of words suppressed are progressively…

78 FR 25116 - Self-Regulatory Organizations; Chicago Mercantile Exchange Inc.; Notice of Filing of Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-29

... Liquidity Factor of CME's CDS Margin Methodology April 23, 2013. Pursuant to Section 19(b)(1) of the... additions; bracketed text indicates deletions. * * * * * CME CDS Liquidity Margin Factor Calculation Methodology The Liquidity Factor will be calculated as the sum of two components: (1) A concentration charge...

75 FR 14648 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by NYSE Amex LLC Deleting...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-26

... (Business Continuity and Contingency Plans) and adopt new Rule 4370--NYSE Amex Equities (Business Continuity... Continuity and Contingency Plans) as substantively duplicative of NASD Rules 3510 (Business Continuity Plans... Equities (Business Continuity and Contingency Plans) to remove the existing text and incorporate NASD Rules...

75 FR 21061 - Self-Regulatory Organizations; Chicago Stock Exchange, Inc.; Notice of Filing of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

... exchange to a fully automated limit-order matching system. This filing would alter or eliminate references... Article 6, Rule 11 (Continuing Education for Registered Persons), we are deleting the rule text which was..., which addressed cancellation or modification of transactions due to systems malfunctions or disruptions...

Species of the Mississippi River Headwaters Reservoirs Region.

DTIC Science & Technology

1976-07-01

inventory and analysis system (ERIAS). _ 00, ’<*" 14175 JAM TO WJ COITION OF > MOV «S IS OBSOLETE UNCLASSIFIED SECURITY CLASSIFICATION1 OF THIS...COMMON) SUNFISH, GREEN (SUNFISH), PUMPKIN SEED SWALLOW, BANK SWALLOW, BARN SWALLOW, ROUGH-WINGED SWALLOW, TREE SWAN, WHISTLING SWIFT

78 FR 16213 - Refunds and Exchanges

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-14

... POSTAL SERVICE 39 CFR Part 111 Refunds and Exchanges AGENCY: Postal Service TM . ACTION: Proposed rule. SUMMARY: The Postal Service TM proposes to revise Mailing Standards of the United States Postal Service, Domestic Mail Manual (DMM[supreg]) 604.9, and other DMM sections, to remove obsolete standards...

Maintenance Budgeting.

ERIC Educational Resources Information Center

Smith, J. McCree

Three methods for the preparation of maintenance budgets are discussed--(1) a traditional method, inconclusive and obsolete, based on gross square footage, (2) the formula approach method based on building classification (wood-frame, masonry-wood, masonry-concrete) with maintenance cost factors for each type plus custodial service rates by type of…

Cryptography: It’s Not Just For Electronic Mail Anymore

DTIC Science & Technology

1993-03-01

David Chaum . Security without identification: Transaction systems to make big brother obsolete. Communications of the ACM, 28(10): 1030-1044, Oc- tober...Jeannette Wing, Maurice Herlihy, Stewart Clamen, David Detlefs, Karen Kietzke, Richard Lerner, and Su-Yuen Ling. The Avalon language: A tutorial

What Lies Beyond the Online Catalog?

ERIC Educational Resources Information Center

Matthews, Joseph R.; And Others

1985-01-01

Five prominent consultants project technological advancements that, in some cases, will enhance current library systems, and in many cases will cause them to become obsolete. Major trends include advances in mainframe and microcomputing technology, development of inexpensive local area networks and telecommunications gateways, and the advent of…

Is the Classroom Obsolete in the Twenty-First Century?

ERIC Educational Resources Information Center

Benade, Leon

2017-01-01

Lefebvre's triadic conception of "spatial practice, representations of space and representational spaces" provides the theoretical framework of this article, which recognises a productive relationship between space and social relations. Its writing stems from a current and ongoing qualitative study of innovative teaching and learning…

Are existing irrigation salinity leaching requirement guidelines overly conservative or obsolete?

USDA-ARS?s Scientific Manuscript database

Water scarcity and increased frequency of drought, resulting from erratic weather attributable to climatic change or alterations in historical weather patterns, have caused greater scrutiny of irrigated agriculture’s demand on water resources. The traditional guidelines for the calculation of the c...

Foundations for a Post-Modern Curriculum.

ERIC Educational Resources Information Center

Doll, William E., Jr.

This paper suggests that present-day curriculum, based on Newtonian thought, has been rendered obsolete by the holistic and interactive "post-modern" world view based on quantum physics, nonlinear mathematics, general systems theory, and Ilya Prigogine's nonequilibrium thermodynamics. The Newtonian world view, which is linear and…

Mistakes in the usage of anatomical terminology in clinical practice.

PubMed

Kachlik, David; Bozdechova, Ivana; Cech, Pavel; Musil, Vladimir; Baca, Vaclav

2009-06-01

Anatomical terminology serves as a basic communication tool in all the medical fields. Therefore Latin anatomical nomenclature has been repetitively issued and revised from 1895 (Basiliensia Nomina Anatomica) until 1998, when the last version was approved and published as the Terminologia Anatomica (International Anatomical Terminology) by the Federative Committee on Anatomical Terminology. A brief history of the terminology and nomenclature development is mentioned, along with the concept and contributions of the Terminologia Anatomica including the employed abbreviations. Examples of obsolete anatomical terms and their current synonyms are listed. Clinicians entered the process of the nomenclature revision and this aspect is demonstrated with several examples of terms used in clinical fields only, some already incorporated in the Terminologia Anatomica and a few obsolete terms still alive in non-theoretical communication. Frequent mistakes in grammar and orthography are stated as well. Authors of the article strongly recommend the use of the recent revision of the Latin anatomical nomenclature both in theoretical and clinical medicine.

E-cigarettes: methodological and ideological issues and research priorities.

PubMed

Etter, Jean-François

2015-02-16

Cigarette combustion, rather than either tobacco or nicotine, is the cause of a public health disaster. Fortunately, several new technologies that vaporize nicotine or tobacco, and may make cigarettes obsolete, have recently appeared. Research priorities include the effects of vaporizers on smoking cessation and initiation, their safety and toxicity, use by non-smokers, dual use of vaporizers and cigarettes, passive vaping, renormalization of smoking, and the development of messages that effectively communicate the continuum of risk for tobacco and nicotine products. A major difficulty is that we are chasing a moving target. New products constantly appear, and research results are often obsolete by the time they are published. Vaporizers do not need to be safe, only safer than cigarettes. However, harm reduction principles are often misunderstood or rejected. In the context of a fierce ideological debate, and major investments by the tobacco industry, it is crucial that independent researchers provide regulators and the public with evidence-based guidance. The methodological and ideological hurdles on this path are discussed in this commentary.

Strategic exploration of battery waste management: A game-theoretic approach.

PubMed

Kaushal, Rajendra Kumar; Nema, Arvind K; Chaudhary, Jyoti

2015-07-01

Electronic waste or e-waste is the fastest growing stream of solid waste today. It contains both toxic substances as well as valuable resources. The present study uses a non-cooperative game-theoretic approach for efficient management of e-waste, particularly batteries that contribute a major portion of any e-waste stream and further analyses the economic consequences of recycling of these obsolete, discarded batteries. Results suggest that the recycler would prefer to collect the obsolete batteries directly from the consumer rather than from the manufacturer, only if, the incentive return to the consumer is less than 33.92% of the price of the battery, the recycling fee is less than 6.46% of the price of the battery, and the price of the recycled material is more than 31.08% of the price of the battery. The manufacturer's preferred choice of charging a green tax from the consumer can be fruitful for the battery recycling chain. © The Author(s) 2015.

77 FR 5183 - Review and Approval of Existing Ordinances or Resolutions; Repeal

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

... DEPARTMENT OF THE INTERIOR National Indian Gaming Commission 25 CFR Part 523 RIN 3141-AA45 Review and Approval of Existing Ordinances or Resolutions; Repeal AGENCY: National Indian Gaming Commission. ACTION: Final rule. SUMMARY: The National Indian Gaming Commission is repealing obsolete regulations...

Topical Hazard Evaluation of Candidate Insect Repellent AI3-36539, 1-(Cyclohexylcarbonyl)-2-Ethylipiperidine.

DTIC Science & Technology

1977-05-12

form and concentration I~ tended for usage. PORN - - $ ,, ~~ ~~ 1413 ( OnION OF I NOV 555 OBSOLETE clasaif ~ed _____ -~~ -~~~~~~~~~•-~~~~-- -~~ ‘~i

Disposable Scholarship?

ERIC Educational Resources Information Center

Miller, Fredrick

2004-01-01

The digital materials that faculty produce for their classrooms often are saved only to storage devices that might become obsolete in a few years. Without an institutional effort to provide access systems, storage, and services for their digital media, are campuses in danger of creating "Disposable Scholarship"? In this article, the author…

Rust in Peace: Finding Hope for the Future in the Graveyards of Technology.

ERIC Educational Resources Information Center

Jungk, Robert

1984-01-01

When a form of high technology becomes obsolete, many people acquire a fear and distrust of the future--a neurosis called the ruins complex. But humanity can respond positively to the ghosts of dead technology and invent a hopeful future. (Author/RM)

Dealing With Obsolescence.

ERIC Educational Resources Information Center

Maiden, Jeffrey A.; Zepeda, Sally J.

1998-01-01

Emerging technology changes to obsolete technology in a short time. Formal policies need to be adopted as technology becomes a more fundamental element of school administrative and instructional programs. A survey of 17 unified school districts in 2 midwestern states revealed that only 2 districts had a formal written obsolescence policy. (MLF)

What Recruiters Should Look for in Applicants.

ERIC Educational Resources Information Center

Steele, E.W.

1981-01-01

One method for determining requirements of job applicants is to survey, by function, various segments of the company. A three-part questionnaire was designed to identify the preferences of hiring supervisors, the personal attitudes of management, and feelings related to recruiting women/minorities and obsolete employees. (Author/KMF)

77 FR 53962 - Technical Standard Order (TSO)-C65a, Airborne Doppler Radar Ground Speed and/or Drift Angle...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-04

... measuring equipment described by this TSO was used to provide inputs to semiautomatic self-contained dead... dead reckoning navigation systems obsolete. On August 18, 1983, the FAA published TSO-C65a. The FAA has...

Emission Measurements of Open Area Combustion Sources with an Unmanned Aerial System

EPA Science Inventory

miniaturized sensor/sampler system (“Kolibri”) on a six-motor, unmanned aerial system (UAS) was used to quantify emissions from open burning of obsolete military propellants. The UAS afforded the ability to sample plume emissions at altitude and from a safe distance ...

Guidelines for replacement of deficient bridges with low-water stream crossings in the rural Midwest.

DOT National Transportation Integrated Search

2017-02-01

This report provides guidance to public officials and engineers considering the replacement of a deficient or obsolete bridge with a low-water stream crossing (LWSC). An LWSC is a structure that is occasionally overtopped by floodwaters and is likely...

75 FR 38645 - Standards Improvement Project-Phase III

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-02

... are specified as ``ID,'' followed by the number of the document. OSHA posts these referenced materials... medical-testing requirement and eliminating an unnecessary and obsolete medical test required in both the... Sec. 1915.1001(h)(4)(ii) requires employers to perform quantitative and qualitative fit testing ``at...

Sleep Can Eliminate List-Method Directed Forgetting

ERIC Educational Resources Information Center

Abel, Magdalena; Bäuml, Karl-Heinz T.

2013-01-01

Recent work suggests a link between sleep and memory consolidation, indicating that sleep in comparison to wakefulness stabilizes memories. However, relatively little is known about how sleep affects forgetting. Here we examined whether sleep influences directed forgetting, the finding that people can intentionally forget obsolete memories when…

Dynamical Reference Frame - Current Relevance and Future Prospects

DTIC Science & Technology

2000-03-01

mentioned that the concepts of ecliptic , obliquity , and mean equator are now obsolete in the context of modern ephemeris creation. 2. Ephemerides...based upon the ICRF, there is no longer an explicit use of the celestial equator, equinox, or ecliptic in the ephemeris creation process. These elements

[The status and current problems of the radiation protection support for Naval personnel].

PubMed

Sharaevskiĭ, G Iu; Murin, M B; Belikov, A D; Petrov, O I

1999-07-01

The article focuses on the radiation problems for the Navy personnel dealing with the nuclear and radioactive waste, since the existing standards become obsolete due to some new technologies in the development of the materials, endangering the environment and people's health.

Gifted Education in Argentina

ERIC Educational Resources Information Center

Irueste, Paula

2017-01-01

In this article, we review the advancement of gifted education in Argentina which has been scarce and discontinuous, particularly, in the public sphere. About the primary conception of giftedness and/or talent, we mention the obsolete struggle between those who only consider a high intellectual coefficient (IQ) versus a more comprehensive…

State Financing of Higher Education: A New Look at an Old Problem.

ERIC Educational Resources Information Center

Fischer, Frederick J.

1990-01-01

There is an implicit general plan currently uniting federal and state financing policies, however, it is inefficient, inequitable, and ineffective, involving obsolete state financing policies and mistaken federal responses. Implementation of another plan available would require federal intervention in state financing policies. (MLW)

The Warm, Rich Sound of Valve Guitar Amplifiers

ERIC Educational Resources Information Center

Keeports, David

2017-01-01

Practical solid state diodes and transistors have made glass valve technology nearly obsolete. Nevertheless, valves survive largely because electric guitar players much prefer the sound of valve amplifiers to the sound of transistor amplifiers. This paper discusses the introductory-level physics behind that preference. Overdriving an amplifier…

The Economics of Has-Beens

ERIC Educational Resources Information Center

MacDonald, Glenn; Weisbach, Michael S.

2004-01-01

The evolution of technology causes human capital to become obsolete. We study this phenomenon in an overlapping generations setting, assuming that technology evolves stochastically and that older workers find updating uneconomic. Experience and learning by doing may offer the old some income protection, but technology advance always turns them…

Virtual Bridge Design Challenge

ERIC Educational Resources Information Center

Mitts, Charles R.

2013-01-01

This design/problem-solving activity challenges students to design a replacement bridge for one that has been designated as either structurally deficient or functionally obsolete. The Aycock MS Technology/STEM Magnet Program Virtual Bridge Design Challenge is an authentic introduction to the engineering design process. It is a socially relevant…

In vitro and in silico studies of urea-induced denaturation of yeast iso-1-cytochrome c and its deletants at pH 6.0 and 25 °C.

PubMed

Haque, Md Anzarul; Zaidi, Sobia; Ubaid-Ullah, Shah; Prakash, Amresh; Hassan, Md Imtaiyaz; Islam, Asimul; Batra, Janendra K; Ahmad, Faizan

2015-01-01

Yeast iso-1-cytochrome c (y-cyt-c) has five extra residues at N-terminus in comparison to the horse cytochrome c. These residues are numbered as -5 to -1. Here, these extra residues are sequentially removed from y-cyt-c to establish their role in folding and stability of the protein. We performed urea-induced denaturation of wild-type (WT) y-cyt-c and its deletants. Denaturation was followed by observing change in Δε405 (probe for measuring change in the heme environment within the protein), [θ]405 (probe for measuring the change in Phe82 and Met80 axial bonding), [θ]222 (probe for measuring change in secondary structure) and [θ]416 (probe for measuring change in the heme-methionine environment). The urea-induced reversible denaturation curves were used to estimate Δ[Formula: see text], the value of Gibbs free energy change (ΔGD) in the absence of urea; Cm, the midpoint of the denaturation curve, i.e. molar urea concentration ([urea]) at which ΔGD = 0; and m, the slope (=∂ΔGD/∂[urea]). Our in vitro results clearly show that except Δ(-5/-4) all deletants are less stable than WT protein. Coincidence of normalized transition curves of all physical properties suggests that unfolding/refolding of WT protein and its deletants is a two-state process. To confirm our in vitro observations, we performed 40 ns MD simulation of both WT y-cyt-c and its deletants. MD simulation results clearly show that extra N-terminal residues play a role in stability but not in folding of the protein.

Design and Implementation of a Prototype Microcomputer Database Management System for the Standardization of Data Elements for the Department of Defense

DTIC Science & Technology

1990-09-01

Justification Cat: Left Timeliness Identifier: Qwe (FI] Domain I Def Text: -Press [F3 to nove in/out of the fields below. Use ARROW keys to scroll- Rec: Host...Delete a record Elemont Creator ID: Justification Cat: Left Timeliness Identifier: Qwe [FI) Domain Def Text: - Press (F3) to move in/out of the...Number: 1 Alias Name: Accounting Code Data Value Type ID: QL Max Length Characters: 34 Timeliness ID: Qwe Justification Category: Left Creator ID: Domain

76 FR 39960 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-07

...-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule... Exchange Act of 1934, as amended (the ``Act''). Upon effectiveness of a plan filed pursuant to Rule 17d-2...(a) through 9.25, which concern advertising and sales literature, would be deleted and the text of...

77 FR 24408 - Modification of Significant New Uses of Tris Carbamoyl Triazine; Technical Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

...) determined that the placement of the correction text in that document did not satisfy OFR's format... final rule? Section 553 of the Administrative Procedure Act (APA), 5 U.S.C. 553(b)(3)(B), provides that... harm resulting from deleting the unnecessary requirement for a developmental effect warning. EPA finds...

Engineering Education Problems. The Laboratory Equipment Factor.

ERIC Educational Resources Information Center

National Society of Professional Engineers, Washington, DC.

Presented is a pilot study focusing attention on problems of deteriorating physical plants and inadequate/obsolete equipment contributing to the current crisis in engineering education. Data are reported from a survey instrument (included in an appendix) from 26 colleges/universities, representing 168 programs out of a national total of 1212…

International Balance of Payments Program--Accounting, Reporting and Estimating

DTIC Science & Technology

1969-01-16

nonappropriated fund, and individual contract hire). • Change 2, 9/16/69 -3- DEPARTMENT OF DEFENSE DIRECTIVES SYSTEM TRANSMITTAL NUMBER DATE I STR I ?UT...WHEN PRESCRIBED ACTION HAS BEEN TAKEN, THIS TRANSMITTAL SHOULD BE FILED WITH THE BASIC DOCUMENT SD FORN 106--1 PREVIOUS EOITIONS ARE OBSOLETE MUNG (R

The Sexuality Curriculum and Youth Culture. Counterpoints, Volume 392

ERIC Educational Resources Information Center

Carlson, Dennis, Ed.; Roseboro, Donyell L., Ed.

2011-01-01

The book aims to change the conversation about sexuality education for adolescents, making it consistent with a democratic cultural politics that is attuned to changes in youth and popular culture. Traditional sex education is nearly obsolete; sexuality curriculum is now primarily learned through popular culture and youth culture, which teach…

Guidelines for replacement of deficient bridges with low-water stream crossings in the rural Midwest : technical summary.

DOT National Transportation Integrated Search

2017-02-01

This report provides guidance to public officials and engineers considering the replacement of a deficient or obsolete bridge with a low-water stream crossing (LWSC). An LWSC is a structure that is occasionally overtopped by floodwaters and is likely...

LPT. Shield test control building (TAN645), north facade. Camera facing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LPT. Shield test control building (TAN-645), north facade. Camera facing south. Obsolete sign dating from post-1970 program says "Energy and Systems Technology Experimental Facility, INEL." INEEL negative no. HD-40-5-4 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Ten Schools and School Districts to Get Excited About

ERIC Educational Resources Information Center

Doblar, D. Douglas

2009-01-01

Calls for schools to "improve" are everywhere, but recently calls for schools to "transform" have proliferated, based on the idea that schools are not simply underperforming but outdated if not obsolete. Most prominently, scholars and authors such as Phillip Schlechty, Peter Senge, and Francis Duffy have targeted school and…

EXTRACTION TECHNIQUES FOR THE REMOVAL OF ARSENICALS FROM SEAFOOD EXPOSURE MATRICES WITH ICP-MS DETECTION

EPA Science Inventory

Most of the existing arsenic dietary databases were developed from the analysis of total arsenic in water and dietary samples. These databases have been used to estimate arsenic exposure and in turn human health risk. However, these dietary databases are becoming obsolete as the ...

Education and Ecstasy.

ERIC Educational Resources Information Center

Leonard, George B.

The highly interactive, regenerative, technological society now emerging will require something akin to mass genius, mass creativity, and lifelong learning; and schools as they now exist are already obsolete. Education of the future will be, and could be now, a utopian, voluntary, joyful, lifetime experience for its own sake. Our present level of…

Multimedia in Education: Summary Chapter.

ERIC Educational Resources Information Center

Hooper, Kristina

1986-01-01

This summary of issues addressed at the conference identifies 10 important themes: (1) the nature of interactivity, and whether linear presentations are obsolete; (2) what can be done with all the imagery made possible with videodisks and the sounds enabled by compact disks, and whether any of this is really new; (3) whether emotional…

A Tale of Two Clouds

ERIC Educational Resources Information Center

Gray, Terry

2010-01-01

The University of Washington (UW) adopted a dual-provider cloud-computing strategy, focusing initially on software as a service. The original project--to replace an obsolete alumni e-mail system--resulted in a cloud solution that soon grew to encompass the entire campus community. The policies and contract terms UW developed, focusing on…

Strengthen Your Principal's Resource Library

ERIC Educational Resources Information Center

Lasky, Beth; Karge, Belinda Dunnick

2009-01-01

How many times do teachers wander into their principal's office for advice, support, guidance, or recommendations, only to find that those books on the shelf are outdated or obsolete? How many times have principals attended individualized education program (IEP) meetings and wished they understood all the new provisions of federal laws? And when…

77 FR 30888 - Heating, Cooling, and Lighting Standards for Bureau-Funded Dormitory Facilities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

...As required by the No Child Left Behind Act of 2001, the Secretary of the Interior has developed regulations using negotiated rulemaking that address heating, cooling, and lighting standards for Bureau-funded dormitory facilities. These regulations also make a technical change to remove an obsolete reference.

The Evolving Demand for Skills.

ERIC Educational Resources Information Center

Greenspan, Alan

From a macroeconomic perspective, the evolving demand for skills in the United States has been triggered by the accelerated expansion of computer and information technology, which has, in turn, brought significant changes to the workplace. Technological advances have made some wholly manual jobs obsolete. But even for many other workers, a rapidly…

Crown management and stand density

Treesearch

Thomas J. Dean; V. Clark Baldwin

1996-01-01

Determination of optimal stand-density continues to be a difficult problem. A trial cannot be established on every combination of soils, topography, and climate possible across the range of a widely distributed species such as loblolly pine, and continual advancements in nutrition and vegetation management, breeding, and utilization make established trials obsolete....

Analytical Studies of Three-Dimensional Combustion Processes

DTIC Science & Technology

1989-05-01

Include Area Code) 22c OFFICE SYMBOL Raghunath S. Boray 513-255-9991 WRDC/POPT DD Form 1473, JUN 86 Previous editions are obsolete. SECURITY...enthalpy, and momentum are calculated for each finite volume by summing the contributions from all groups of droplets. Thus, ( Sm )i,J N ((PpM-p)in

The Future of Fractions

ERIC Educational Resources Information Center

Usiskin, Zalman P.

2007-01-01

In the 1970s, the movement to the metric system (which has still not completely occurred in the United States) and the advent of hand-held calculators led some to speculate that decimal representation of numbers would render fractions obsolete. This provocative proposition stimulated Zalman Usiskin to write "The Future of Fractions" in 1979. He…

48 CFR 43.203 - Change order accounting procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

...., engineering costs and costs of obsolete or reperformed work). (2) Costs of added distinct work caused by the...) Contractors' accounting systems are seldom designed to segregate the costs of performing changed work... possible need to revise their accounting procedures to comply with the cost segregation requirements of the...

48 CFR 43.203 - Change order accounting procedures.

Code of Federal Regulations, 2014 CFR

2014-10-01

...., engineering costs and costs of obsolete or reperformed work). (2) Costs of added distinct work caused by the...) Contractors' accounting systems are seldom designed to segregate the costs of performing changed work... possible need to revise their accounting procedures to comply with the cost segregation requirements of the...

48 CFR 43.203 - Change order accounting procedures.

Code of Federal Regulations, 2013 CFR

2013-10-01

...., engineering costs and costs of obsolete or reperformed work). (2) Costs of added distinct work caused by the...) Contractors' accounting systems are seldom designed to segregate the costs of performing changed work... possible need to revise their accounting procedures to comply with the cost segregation requirements of the...

48 CFR 43.203 - Change order accounting procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

...., engineering costs and costs of obsolete or reperformed work). (2) Costs of added distinct work caused by the...) Contractors' accounting systems are seldom designed to segregate the costs of performing changed work... possible need to revise their accounting procedures to comply with the cost segregation requirements of the...

Residues of organochlorine pesticides in surface soil and raw foods from rural areas of the Republic of Tajikistan

EPA Science Inventory

The central Asian Republic of Tajikistan has been an area of extensive historical agricultural pesticide use as well as large scale burials of obsolete banned chlorinated insecticides. The current investigation was a four year study of legacy organochlorine pesticides in surface ...

An Investigation Into the Challenges of Joint Basing

DTIC Science & Technology

2014-06-19

including legal entities, accounting systems, and strategic business unit ( profit center) (Shrivastava, 1986). Physical integration involves bringing...59 ix List of Tables Page Table 1. Military Value Factors and...commercial sector has transformed itself as products become obsolete, competition intensifies, and stakeholders continue to demand that value be maximized

76 FR 72306 - Federal Housing Administration (FHA) Appraiser Roster: Appraiser Qualifications for Placement on...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-23

... Appraiser Roster regulations by replacing the obsolete references to the Credit Alert Interactive Voice Response System (CAIVRS) with references to its successor, the online-based Credit Alert Verification... propose the elimination references to the Credit Alert Interactive Voice Response System (CAIVRS). On July...

76 FR 41441 - Federal Housing Administration (FHA) Appraiser Roster: Appraiser Qualifications for Placement on...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-14

... the FHA Appraiser Roster by replacing the obsolete references to the Credit Alert Interactive Voice Response System with references to its successor, the online-based Credit Alert Verification Reporting...'s Limited Denial of Participation list, or in HUD's Credit Alert Interactive Voice Response System...

Appendix B: Rapid development approaches for system engineering and design

NASA Technical Reports Server (NTRS)

1993-01-01

Conventional processes often produce systems which are obsolete before they are fielded. This paper explores some of the reasons for this, and provides a vision of how we can do better. This vision is based on our explorations in improved processes and system/software engineering tools.

Creolizing the Academy: Embracing Transdisciplinarity to Revive the Humanities and Promote Critical Pedagogy

ERIC Educational Resources Information Center

Parris, LaRose

2018-01-01

Academic administrators are witnessing unprecedented assaults on national humanities funding that would have been unthinkable three decades ago. Many, if not most, academic administrators and policy makers now view the cornerstone of liberal arts education as an educational anachronism, obsolete intellectualism that holds neither import nor…

Personality Characteristics and Choice of Academic Major: Are Traditional Stereotypes Obsolete?

ERIC Educational Resources Information Center

Pringle, Charles D.; DuBose, Philip B.; Yankey, Michael D.

2010-01-01

Among the many reasons for choosing an academic major are stereotypes that students hold of particular occupations and the degree to which they believe that their personalities match those stereotypes. We examined relevant personality characteristics (i.e., achievement motivation, conformity, conscientiousness, creativity and extroversion) of 899…

Engineers' Non-Scientific Models in Technology Education

ERIC Educational Resources Information Center

Norstrom, Per

2013-01-01

Engineers commonly use rules, theories and models that lack scientific justification. Examples include rules of thumb based on experience, but also models based on obsolete science or folk theories. Centrifugal forces, heat and cold as substances, and sucking vacuum all belong to the latter group. These models contradict scientific knowledge, but…

Revisiting an "R"--News and Views of Writing.

ERIC Educational Resources Information Center

Phelps, Joanne; Stempel, Lynn

Despite predictions that handwriting would become obsolete in the age of technology, it is still considered an important skill today. Examples are cited of individuals who improved their understanding of themselves and of particular concepts after writing about their thoughts and feelings. Frequently, dyslexic students are denied access to this…

Feature Extraction Using an Unsupervised Neural Network

DTIC Science & Technology

1991-05-03

with this neural netowrk is given and its connection to exploratory projection pursuit methods is established. DD I 2 P JA d 73 EDITIONj Of I NOV 6s...IS OBSOLETE $IN 0102- LF- 014- 6601 SECURITY CLASSIFICATION OF THIS PAGE (When Daoes Enlered) Feature Extraction using an Unsupervised Neural Network

Soviet Industrial Strategy and Reforms in Vocational Education, 1984-88: Policy Implications and Implementation.

ERIC Educational Resources Information Center

Sowtis, Dennis

1991-01-01

In 1984, Soviet educational reforms increased the number of vocational secondary schools, introduced pupils to vocational education at an earlier age, and strengthened vertical integration between local enterprises and schools. Unintended consequences may be occupational rigidity, course offerings based on obsolete manpower needs, and…

Furniture Faces the Future.

ERIC Educational Resources Information Center

Rittner-Heir, Robbin M.

2000-01-01

Discusses how changes in the educational tools used and the way children are taught have made classroom furniture of the past nearly obsolete. Furniture options for flexibility and buying decisions in tight budgets are addressed, including buying over the Internet. Questions to ask for buying the right furniture for school districts are…

Visualization Skills: A Prerequisite to Advanced Solid Modeling

ERIC Educational Resources Information Center

Gow, George

2007-01-01

Many educators believe that solid modeling software has made teaching two- and three-dimensional visualization skills obsolete. They claim that the visual tools built into the solid modeling software serve as a replacement for the CAD operator's personal visualization skills. They also claim that because solid modeling software can produce…

More Misconceptions to Avoid When Teaching about Plants

ERIC Educational Resources Information Center

Hershey, David R.

2005-01-01

As follow-up to a previous article "Avoid Misconceptions When Teaching about Plants," the author identifies fifty additional misconceptions. Undergeneralizations are added to the list of oversimplifications, obsolete concepts, terms, misidentifications, and flawed research. A glossary at the end of the article compares words used in botany with…

Learning without Education. An Interview with Lewis J. Perelman. Background Briefing Paper.

ERIC Educational Resources Information Center

Easterling, Douglas

This interview with Lewis J. Perelman examines issues raised by his recent book, "School's Out" (1992), which describes the current educational system as an obsolete technology that is rapidly being replaced by the new metaprocess of hyperlearning. Hyperlearning will combine teaching and learning with artificial intelligence, broadband…

76 FR 45403 - Disclosure to Participants

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-29

... regulation on Disclosure to Participants. The regulation is obsolete as a result of the Pension Protection... Benefit Guaranty Corporation's guarantee. The Pension Protection Act of 2006 repealed section 4011 for..., DC 20005, 202-326-4024. (TTY/TDD users may call the Federal relay service toll-free at 1-800- 877...

Aerostat-Based Sampling of Emissions from Open Burning and Open Detonation of Military Ordnance

EPA Science Inventory

Emissions from open detonation (OD), open burning (OB), and static firing (SF) of obsolete military munitions were collected using an aerostat-lofted sampling instrument maneuvered into the plumes with remotely controlled tether winches. PM2.5, PM10, metals, volatile organic comp...

78 FR 33134 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

... Post No Preference Light Only Quotation May 28, 2013. Pursuant to Section 19(b)(1) \\1\\ of the... Quotation (``PNPLO Quotation''). The text of the proposed rule change is available on the Exchange's Web... delete NYSE Arca Options Rule 6.62(cc) to remove references to the PNPLO Quotation. The Exchange adopted...

75 FR 5821 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... Exchange proposes to clarify Nasdaq Rule 7023 to make clear that Historical ModelView information will be available via NasdaqTrader.com and that references to the Historical TotalView data product will be deleted... text of the proposed rule change is available from Nasdaq's Web site at http://nasdaq.cchwallstreet.com...

76 FR 16466 - Self-Regulatory Organizations; Notice of Filing and Order Granting Accelerated Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... EDGX Exchange, Inc. To Delete the Description of and All References to Step-Up Orders in EDGX Rules... of and all references to Step- Up orders. The text of the proposed rule change is attached as Exhibit... (``Commission'') a proposed rule change to amend EDGX Rule 11.9 regarding the description of the Step-up order...

Project F. A. S. T.: Facilitating Academic Study Techniques for Handicapped Children. Volume 2. Final Report.

ERIC Educational Resources Information Center

Martin, Clessen J.

Volume 2, the appendix to the final report of Project FAST, consists of prose selections used to study the effects of text reduction techniques on the comprehension and recall of written materials among visually handicapped and hearing impaired subjects. Each selection is presented in various versions such as 10 percent subjective deleted, 20…

78 FR 41163 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-09

... Parameter (``ACE Parameter'') in Rule 1080.08(i), which is the price range outside of which a Complex Order.... Proposed new language is italicized; deleted text is in brackets. * * * * * Rule 1080. Phlx XL and Phlx XL...\\ See Rule 1080.08(a). Currently, the ACE Parameter is always a percentage, not less than 3 percent. The...

Vzaimodeystviya--A Soviet Problem.

DTIC Science & Technology

1981-06-01

necessary and Identify by block number) 241 ABST’RACr (Cthate at mewr ee ff nacmew an idemtlby by block nutbee) D OAMM72 IM7 EVITIO11 OF INOV 65 IS OBSOLETE...it necessary to depart the battlefield to conduct strategic discussions with his ally, King Augustus of Poland . Peter appointed Duc du Croy (a

Preserving the Whole: A Two-Track Approach to Rescuing Social Science Data and Metadata.

ERIC Educational Resources Information Center

Green, Ann; Dionne, JoAnn; Dennis, Martin

Focusing on the experience of the Yale University (Connecticut) social science data preservation project, this document presents a case study of migration as a preservation strategy, exploring options for migrating data stored in a technically obsolete format and their associated documentation stored on paper. The first section provides background…

To repeal an obsolete provision in title 49, United States Code, requiring motor vehicle insurance cost reporting.

THOMAS, 112th Congress

Rep. Owens, William L. [D-NY-23

2012-05-08

House - 05/11/2012 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see H.R.5859, which became Public Law 112-252 on 1/10/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Indepth investigation of the system currently used by the Las Vegas Metropolitan Police Department to store and process crash data and all other interconnected systems.

DOT National Transportation Integrated Search

2016-12-31

Some of the existing software and hardware used by law enforcement agencies to collect crash data are obsolete for several reasons, ranging from budget constraints to lack of coordination across various groups. The most significant consequence of usi...

A Look at Lifelong Learning.

ERIC Educational Resources Information Center

Dutton, Donnie

Adults must continue to learn. The accelerating pace of cultural change has made today's knowledge and skills tomorrow's obsolescence. A society that makes its educational investment almost entirely in children and youth is on the way to becoming obsolete and is reducing its survival chances. To promote the cause of lifelong learning, we need to…

Blueprint for Tomorrow: Redesigning Schools for Student-Centered Learning

ERIC Educational Resources Information Center

Nair, Prakash

2014-01-01

The United States has about $2 trillion tied up in aging school facilities. School districts throughout the country spend about $12 billion every year keeping this infrastructure going. Yet almost all of the new money we pour into school facilities reinforces an existing--and obsolete--model of schooling. In "Blueprint for Tomorrow,"…

Training Detractors in FORSCOM Divisions and How They Are Handled

DTIC Science & Technology

1980-05-01

mandatory training on conducting effective combat training, and explored four resource areas No. DD JAN 1473 EDITION OF I NOV 65 IS OBSOLETE...INSTITUTIONAL RSCH I USA AIR DEFENSE SCHOOL AITN: AISA -CD-MS 1 USAA|)S-LIBRARY-DOCUMENIS I USA AIR DEFENSE BOAR) ATIN: FILES REPOSITORY I USA sERGEANTS

Electrical Discharge Machining (EDM) Gun Barrel Bore and Rifling Feasibility Study

DTIC Science & Technology

1974-09-01

11 I + | , + + in cri es sss asa f^piis aisa -^ nro^ HH^ S I I + VD 1X> ^3 Wfl ^mvo ^00...and high erosion rates encountered in high performance gun designs such as the GAU-7/A DD , :°N RM73 1473 EDITION OF 1 NOV 65 IS OBSOLETE

78 FR 69539 - Removal of Attestation Process for Facilities Using H-1A Registered Nurses

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-20

... of Attestation Process for Facilities Using H-1A Registered Nurses AGENCY: Employment and Training... registered nurses under the H-1A visa program. These subparts became obsolete after the authorizing statute... nonimmigrant classification exclusively for the temporary admission and employment of registered nurses, which...

High-resolution genetic and physical mapping of eastern filbert blight resistance in hazelnut

Treesearch

Vidyasagar Sathuvall; Shawn A. Mehlenbacher

2012-01-01

Eastern filbert blight (EFB), caused by the pyrenomycete Anisogramma anomala, is a serious threat to the hazelnut (Corylus avellana L.) industry in the Pacific Northwest. A dominant allele at a single locus from the obsolete pollenizer 'Gasaway' confers a very high level of resistance, and has been extensively used in...

Prospective Conversion: Data Transfer between Fossil and New Microcomputer Technologies in Libraries.

ERIC Educational Resources Information Center

Vratny-Watts, Janet; Valauskas, Edward J.

1989-01-01

Discusses the technological changes that will necessitate the prospective conversion of library data over the next decade and addresses the problems of converting data from obsolete personal computers to newer models that feature radically different operating systems. Three case studies are used to illustrate possible scenarios. (11 references)…

Are Memberships in Race, Ethnicity, and Gender Categories Merely Surface Characteristics?

ERIC Educational Resources Information Center

Eagly, Alice H.; Chin, Jean Lau

2010-01-01

Comments on Deep-level diversity and leadership by Kristen M. Klein and Mo Wang. In the special issue on Diversity and Leadership (April 2010), the authors made a strong case for the importance of diversity in workplace leadership, rejected premature declarations that workplace discrimination is obsolete, and called for leadership theories that…

Musical Interlude

ERIC Educational Resources Information Center

Radda, Chuck

2005-01-01

In this article, the author describes his use of an old obsolete and quaintly archaic form of entertainment in order to create a more lively academic discussion. He introduced the songs of Scottish folk/pop singer, Al Stewart, as an effective teaching tool in his class. Students listened to several Al Stewart songs: (1) "A League of Notions"--a…

How Financial Innovation Has Made Textbook Monetary Theory Obsolete.

ERIC Educational Resources Information Center

Gilbody, John

1988-01-01

Argues that much of the monetary theory in economics textbooks has not changed in accordance with the facts of monetary history. Contends that by neglecting institutional changes in the monetary system in the 50 years since the publication of Keynes' General Theory, many textbooks are now in danger of seriously misleading their readers. (GEA)

78 FR 59339 - Intracoastal Waterway Route “Magenta Line” on NOAA Nautical Charts

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-26

... waterways have been based principally on surveys made from 60 to 80 years ago and, necessarily, are obsolete... found where the charted Intracoastal Waterway Route (``magenta line'') passes on the wrong side of aids... specifically seeks comments regarding: 1. How do you currently access the magenta line? On paper nautical...

Inexpensive Miniature Programmable Magnetic Stirrer from Reconfigured Computer Parts

ERIC Educational Resources Information Center

Mercer, Conan; Leech, Donal

2017-01-01

This technology report outlines a robust and easy to assemble magnetic stirrer that is programmable. All of the parts are recycled from obsolete computer hardware except the Arduino microcontroller and motor driver, at a total cost of around $40. This multidisciplinary approach introduces microcontrollers to students and grants the opportunity to…

Computer Software for Life Cycle Cost.

DTIC Science & Technology

1987-04-01

34 111. 1111I .25 IL4 jj 16 MICROCOPY RESOLUTION TEST CHART hut FILE C AIR CoMMNAMN STFF COLLG STUJDET PORTO i COMpUTER SOFTWARE FOR LIFE CYCLE CO879...obsolete), physical life (utility before physically wearing out), or application life (utility in a given function)." (7:5) The costs are usually

83. View of specialized maintenance shop in transmitter building no. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

83. View of specialized maintenance shop in transmitter building no. 101, with shelves of obsolete electronic equipment with disposition and shipping tags. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

Education and Training in Japan in the Cybernetic Age. Program Report No. 85-B2.

ERIC Educational Resources Information Center

Muta, Hiromitsu

The introduction of computers and other microelectronic equipment throughout the Japanese economy has not affected employment negatively, owing to economic growth and the adaptability of the workers and business organizations affected. Because rapid advances in technology are making many specialized skills and areas of knowledge obsolete, it is…

Branches of Opportunity

ERIC Educational Resources Information Center

Giles, David

2013-01-01

As more and more New Yorkers turn to digital books, Wikipedia and other online tools for information and entertainment, there is a growing sense that the age of the public library is over. But, in reality, New York City's public libraries are more essential than ever. Far from becoming obsolete, the city's three public library systems--Brooklyn,…

77 FR 5193 - Retrospective Review Under E.O. 13563: Shipping-Removal of Obsolete Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

... Program, which replaced the Operating-Differential Subsidy (ODS) Program. Therefore, the regulations pertaining to the ODS Program and the Construction-Differential (CDS) Program are no longer in use. In... regulations 46 CFR parts 251, 252, 276, 280, 281,282, and 283. The regulations related to the ODS Program are...

Teaching Software Engineering by Means of Computer-Game Development: Challenges and Opportunities

ERIC Educational Resources Information Center

Cagiltay, Nergiz Ercil

2007-01-01

Software-engineering education programs are intended to prepare students for a field that involves rapidly changing conditions and expectations. Thus, there is always a danger that the skills and the knowledge provided may soon become obsolete. This paper describes results and draws on experiences from the implementation of a computer…

The Big Fish

ERIC Educational Resources Information Center

DeLisle, Rebecca; Hargis, Jace

2005-01-01

The Killer Whale, Shamu jumps through hoops and splashes tourists in hopes for the big fish, not because of passion, desire or simply the enjoyment of doing so. What would happen if those fish were obsolete? Would this killer whale be able to find the passion to continue to entertain people? Or would Shamu find other exciting activities to do…

36 CFR 1223.2 - What definitions apply to this part?

Code of Federal Regulations, 2010 CFR

2010-07-01

.... (b) As used in part 1223— Cycle means the periodic removal of obsolete copies of vital records and... agency's normal place of business where records are kept until eligible for final disposition. Vital... emergency occur in an agency's normal place of business. Vital records means essential agency records that...

Biological Defense: DOD Has Strengthened Coordination on Medical Countermeasures but Can Improve Its Process for Threat Prioritization

DTIC Science & Technology

2014-05-01

applicability of DOD Directive 6205.3, which they believe was made obsolete when the 2001 Quadrennial Defense Review established DOD’s emphasis on...gas masks, gloves, and boots, or biosurveillance and detection equipment in our analysis. We included in our definition of “biological threat

24 CFR 970.15 - Specific criteria for HUD approval of demolition requests.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING PROJECTS § 970.15 Specific criteria for HUD approval of demolition requests. (a) In addition to... public housing project must certify that the project: (1) Is obsolete as to physical condition, location... modifications is cost-effective to return the public housing project or portion of the project to useful life...

3. CONSTRUCTION DETAIL WEST PORTAL SHOWING CONCRETE LINING. NOTE DRILL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. CONSTRUCTION DETAIL WEST PORTAL SHOWING CONCRETE LINING. NOTE DRILL HOLES IN GRANITE AT RIGHT EDGE. US GEOLOGICAL SURVEY BENCHMARK AT BOTTOM CORNER OF SIDEWALK - 4,621 FEET. SLOT IN FAR WALL FOR SEMAPHORE OF OBSOLETE CARBON MONOXIDE WARNING SYSTEM. - Wawona Tunnel, Wawona Road through Turtleback Dome, Yosemite Village, Mariposa County, CA

PROCESS WATER BUILDING, TRA605. CONTROL PANEL SUPPLIES STATUS INDICATORS. CARD ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PROCESS WATER BUILDING, TRA-605. CONTROL PANEL SUPPLIES STATUS INDICATORS. CARD IN LOWER RIGHT WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION ON ORIGINAL NEGATIVE. INL NEGATIVE NO. 4219. Unknown Photographer, 2/13/1952 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Workability of Mass Concrete. Report 2. Supplemental Proportioning Parameters.

DTIC Science & Technology

1996-09-01

Information given in the report shall not be used in advertising or sales promotion to indicate endorsement of this product by U.S. Government. 14 Chapter 2... SALES PROMOTION TO INDICATE EITHER EXPLICITLY OR IMPLICITLY ENDORSEMENT OF THIS PRODUCT BY THE U.S. GOVERNMENT. FORM EDITION OF 1 SEP 84 IS OBSOLETE

Visions of Music

ERIC Educational Resources Information Center

Root, Susan M.

2008-01-01

As the author was discussing the future of CD design with her high-school students concerning its possibility of becoming obsolete as the ability to purchase music via the Internet becomes more mainstream, she was reminded of the things that she loves about an album by looking at the pictures, reading the lyrics, touching it and holding it. The…

Education in the Learning Economy: A European Perspective

ERIC Educational Resources Information Center

Lundvall, Bengt-Ake; Rasmussen, Palle; Lorenz, Edward

2008-01-01

Innovation is crucial to the competitiveness of the economies of Europe, and learning is crucial to innovation. The most important trend shift is not that knowledge is becoming more important but that it is becoming obsolete more rapidly than before, so that firms and employees constantly have to learn and acquire new competencies. This involves…

Assessment of DDT and Metabolites in Soil and Sediment of Potentially Contaminated Areas of Belém, Amazon Region, Brazil.

PubMed

Rodrigues, Andreia Oliveira; de Souza, Larissa Costa; da Silva Rocha, Cássia Christina; da Costa, Amilton Cesar Gomes; de Alcântara Mendes, Rosivaldo

2017-07-01

The aim of this study was to evaluate the distribution of DDT and metabolites in surface soils and soil profiles from two areas containing deposits of obsolete pesticides in Belém, Amazon Region, Brazil. DDT and metabolites were extracted by microwave assisted extraction and analyzed by gas chromatography with electron capture detection. Concentrations of total DDT in surface soil samples ranged from 64.22 mg kg -1 in area 1 (A1) to 447.84 mg kg -1 in area 2 (A2). Lower levels were found in soil profiles than at the surface (6.21-21.17 mg kg -1 in A1 and 36.13-113.66 mg kg -1 in A2). pp'-DDT, pp'-DDE and pp'-DDD were detected in sediments at levels of 2.01, 0.96 and 0.35 mg kg -1 , respectively. The ratio (DDE + DDD)/ΣDDT was low indicating the recent introduction of DDT to the environment in the two study areas, through the volatilization and atmospheric deposition of the obsolete pesticides.

Urban groundwater as a possible nutrient source for an estuarine benthic algal bloom

NASA Astrophysics Data System (ADS)

Sewell, P. L.

1982-11-01

The Peel Inlet in Western Australia was used to study the cause of eutrophic conditions in an estuary. In addition to large quantities of nitrogen and phosphorus (at low concentrations) entering the inlet from rivers and drains from agricultural areas, the urban contribution via groundwater was identified. The average nitrogen concentration of urban groundwater under an area serviced with septic tank systems was 12 parts 10 -6. Because of the nature of the soils, very few groundwater samples contained appreciable phosphorus concentrations. However, one area close to the inlet had semiconfined groundwaters with nitrogen and phosphorus concentrations as high as 100 and 0·4 parts 10 -6 respectively. An obsolete dumping site for human excreta was also identified near the urban area, and this is suspected of having contributed to very high concentrations of nitrogen and phosphorus in groundwater which may have already reached the estuary and caused excessive algal growth. Groundwater contours showed the potential for groundwater movement from part of the urban area and also from the obsolete dumping site.

WordlePlus: Expanding Wordle's Use through Natural Interaction and Animation.

PubMed

Jo, Jaemin; Lee, Bongshin; Seo, Jinwook

2015-01-01

Wordle has been commonly used to summarize texts, with each word size-coded by its frequency of occurrences--the more often a word occurs in texts, the bigger it is. The interactive authoring tool WordlePlus leverages natural interaction and animation to give users more control over wordle development. WordlePlus supports direct manipulation of words with pen and touch interaction. It introduces two-word multitouch manipulation, such as concatenating and grouping two words, and provides pen interaction for adding and deleting words. In addition, WordlePlus employs animation to help users create more dynamic and engaging wordles.

Failure of Urological Implants in Spinal Cord Injury Patients due to Infection, Malfunction, and Implants Becoming Obsolete due to Medical Progress and Age-Related Changes in Human Body Making Implant Futile: Report of Three Cases.

PubMed

Vaidyanathan, Subramanian; Soni, Bakul; Singh, Gurpreet; Hughes, Peter; Selmi, Fahed; Mansour, Paul

2013-01-01

Any new clinical data, whether positive or negative, generated about a medical device should be published because health professionals should know which devices do not work, as well as those which do. We report three spinal cord injury patients in whom urological implants failed to work. In the first, paraplegic, patient, a sacral anterior root stimulator failed to produce erection, and a drug delivery system for intracavernosal administration of vasoactive drugs was therefore implanted; however, this implant never functioned (and, furthermore, such penile drug delivery systems to produce erection had effectively become obsolete following the advent of phosphodiesterase type 5 inhibitors). Subsequently, the sacral anterior root stimulator developed a malfunction and the patient therefore learned to perform self-catheterisation. In the second patient, also paraplegic, an artificial urinary sphincter was implanted but the patient developed a postoperative sacral pressure sore. Eight months later, a suprapubic cystostomy was performed as urethral catheterisation was very difficult. The pressure sore had not healed completely even after five years. In the third case, a sacral anterior root stimulator was implanted in a tetraplegic patient in whom, after five years, a penile sheath could not be fitted because of penile retraction. This patient was therefore established on urethral catheter drainage. Later, infection with Staphylococcus aureus around the receiver block necessitated its removal. In conclusion, spinal cord injury patients are at risk of developing pressure sores, wound infections, malfunction of implants, and the inability to use implants because of age-related changes, as well as running the risk of their implants becoming obsolete due to advances in medicine. Some surgical procedures such as dorsal rhizotomy are irreversible. Alternative treatments such as intermittent catheterisations may be less damaging than bladder stimulator in the long term.

Bandwidth Optimization On Design Of Visual Display Information System Based Networking At Politeknik Negeri Bali

NASA Astrophysics Data System (ADS)

Sudiartha, IKG; Catur Bawa, IGNB

2018-01-01

Information can not be separated from the social life of the community, especially in the world of education. One of the information fields is academic calendar information, activity agenda, announcement and campus activity news. In line with technological developments, text-based information is becoming obsolete. For that need creativity to present information more quickly, accurately and interesting by exploiting the development of digital technology and internet. In this paper will be developed applications for the provision of information in the form of visual display, applied to computer network system with multimedia applications. Network-based applications provide ease in updating data through internet services, attractive presentations with multimedia support. The application “Networking Visual Display Information Unit” can be used as a medium that provides information services for students and academic employee more interesting and ease in updating information than the bulletin board. The information presented in the form of Running Text, Latest Information, Agenda, Academic Calendar and Video provide an interesting presentation and in line with technological developments at the Politeknik Negeri Bali. Through this research is expected to create software “Networking Visual Display Information Unit” with optimal bandwidth usage by combining local data sources and data through the network. This research produces visual display design with optimal bandwidth usage and application in the form of supporting software.

76 FR 16468 - Self-Regulatory Organizations; Notice of Filing and Order Granting Accelerated Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... EDGA Exchange, Inc. To Delete the Description of and All References to Step-Up Orders in EDGA Rules... of and all references to Step- Up orders. The text of the proposed rule change is attached as Exhibit... proposed rule change to amend EDGA Rule 11.9 regarding the description of the Step-up order type and modify...

Analysis of National Drug Code Identifiers in Ambulatory E-Prescribing.

PubMed

Dhavle, Ajit A; Ward-Charlerie, Stacy; Rupp, Michael T; Amin, Vishal P; Ruiz, Joshua

2015-11-01

Communication of an accurate and interpretable drug identifier between prescriber and pharmacist is critically important for realizing the potential benefits of electronic prescribing (e-prescribing) while minimizing its risk. The National Drug Code (NDC) is the most commonly used codified drug identifier in ambulatory care e-prescribing, but concerns have been raised regarding its use for this purpose.  To (a) assess the frequency of NDC identifier transmission in ambulatory e-prescribing; (b) characterize the type of NDC identifier transmitted (representative, repackaged, obsolete, private label, and unit dose); and (c) assess the level of agreement between drug descriptions corresponding to NDC identifiers in electronic prescriptions (e-prescriptions) and the free-text drug descriptions that were entered by prescribers.  We analyzed a sample of 49,997 e-prescriptions that were transmitted by ambulatory care prescribers to outlets of a national retail drugstore chain during a single day in April 2014. The First Databank MedKnowledge drug database was used as the primary reference data base to assess the frequency and types of NDC numbers in the e-prescription messages. The FDA's Comprehensive NDC Standard Product Labeling Data Elements File and the National Library of Medicine's RxNorm data file were used as secondary and tertiary references, respectively, to identify NDC numbers that could not be located in the primary reference file. Three experienced reviewers compared the free-text drug description that had been entered by the prescriber with the drug description corresponding to the NDC number from 1 of the 3 reference database files to identify discrepancies. Two licensed pharmacists with residency training and ambulatory care experience served as final adjudicators. A total of 42,602 e-prescriptions contained a value in the NDC field, of which 42,335 (84.71%) were found in 1 of the 3 study reference databases and were thus considered to be valid NDC numbers. A total of 28,172 (67.70%) e-prescriptions in the sample were found to contain a representative NDC number, according to the definition used by the National Council for Prescription Drug Programs (NCPDP). The remaining e-prescriptions consisted of 4 subtypes of unrepresentative NDC numbers. In 41,298 (97.55%) e-prescriptions that contained an NDC number, the drug description associated with the number from 1 of the 3 data source files pointed to the identical semantic drug concept as the free-text drug description that had been entered by the prescriber. However, in 87 (0.21%) e-prescriptions, the free-text drug descriptions and the drug description associated with the NDC number pointed to completely different semantic drug concepts. We found the use of NDC identifiers in our sample of e-prescriptions to be relatively high. However, approximately one-third consisted of unrepresentative NDC numbers (obsolete, repackaged, unit dose, or private label) that have the potential to create workflow disruptions at the dispensing pharmacy. Most disturbing was our finding that more than 2 out of every 1,000 e-prescriptions in our sample contained a free-text drug description that pointed to a completely different drug concept than that associated with its NDC value. Our study suggests the need for e-prescribing technology vendors to maintain accurate and up-to-date drug database files within their systems and to conduct regular validation checks to ensure that the drug descriptions associated with the NDC identifier and the free-text drug description that is sent in the e-prescription message point to the same drug concept. The FDA may need to consider a more active role in ensuring the accuracy of NDC assignment by drug manufacturers.

A Review of the Battle of Britain in Context of AFM 1-1 Principles of War

DTIC Science & Technology

1984-04-01

consists of discussion questions and rationale as an aid for leading a guided discussion.j DD IFO 1473 EDITION OF INOV 65 IS OBSOLETE UNCLASSIFIED...challenge facing England. In June of 1940, Hitler ruled a vast proportion of Europe after easy victories in Poland , Denmark, Norway, and Belgium. On

Karl Marx as a Social Scientist and Utopian Dreamer.

ERIC Educational Resources Information Center

Stevenson, James A.

The central paradox of Karl Marx's work is his belief that the vision of mankind leaving inequality and scarcity behind is attainable. The idea that human alienation, inequality, and need could be rendered obsolete by a future communist society of abundance is a significant failing in Marx's thought. It is at the same time the critical element in…

34. DIABLO POWERHOUSE: ORIGINAL EQUIPMENT WESTINGHOUSE TYPE J RHEOSTAT. ALTHOUGH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. DIABLO POWERHOUSE: ORIGINAL EQUIPMENT WESTINGHOUSE TYPE J RHEOSTAT. ALTHOUGH NOW CONSIDERED OBSOLETE, THE RHEOSTAT IS RETAINED AS BACK-UP EQUIPMENT AND HAS BEEN CALLED INTO SERVICE IN RECENT YEARS WHEN MORE MODERN EQUIPMENT FAILED, 1989. - Skagit Power Development, Diablo Powerhouse, On Skagit River, 6.1 miles upstream from Newhalem, Newhalem, Whatcom County, WA

Benefits and Challenges of Architecture Frameworks

DTIC Science & Technology

2011-06-01

systems and identify emerging and obsolete standards. • The NATO Capability View ( NCV ) serves the analysis and optimization of military ca- pabilities... NCVs show the dependencies between different capabilities and allow detecting gaps and overlaps of capabilities. NCVs deliver indirectly requirements...Email (possibly with vendor-specific extensions/modifications) • Proprietary, and possibly not well-documented, message formats • Web services

The Mathematics Textbook as a Story: A Novel Approach to the Interrogation of Mathematics Curriculum

ERIC Educational Resources Information Center

Dietiker, Leslie C.

2012-01-01

Both the purpose and overarching goal of this dissertation can be summarized with this quote by Buckminster Fuller: "You never change things by fighting the existing reality. To change something, build a new model that makes the existing model obsolete." That is, to enable substantive positive change in mathematics education, this…

23 CFR 750.104 - Signs that may not be permitted in protected areas.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Advertising Adjacent to the Interstate System Under the 1958 Bonus Program § 750.104 Signs that may not be... protected areas: (a) Signs advertising activities that are illegal under State or Federal laws or regulations in effect at the location of such signs or at the location of such activities. (b) Obsolete signs...

The American Welfare State and Future Challanges to Black Education in the Age of Science and Technology.

ERIC Educational Resources Information Center

Hayes, Floyd W., III

The emerging "Managerial Estate," based as it is on knowledge, services, science, and technology, with built-in theories of expendability for people considered obsolete, will increasingly force Afro-Americans and historically-black institutions of higher learning to emphasize self-reliance and self determination. Moreover, urban public schools…

Developing Collective Learning Extension for Rapidly Evolving Information System Courses

ERIC Educational Resources Information Center

Agarwal, Nitin; Ahmed, Faysal

2017-01-01

Due to rapidly evolving Information System (IS) technologies, instructors find themselves stuck in the constant game of catching up. On the same hand students find their skills obsolete almost as soon as they graduate. As part of IS curriculum and education, we need to emphasize more on teaching the students "how to learn" while keeping…

Magnetic Resonance Determinations of Structure and Reaction Kinetics of Epoxy/Amine Systems.

DTIC Science & Technology

1981-12-31

AD- AISA 542 MCDONNELL DOUGLAS RESEARCH LABS ST LOUIS MO FIG 7/4 MAGNETIC RESONANCE DETERMINATIONS OF STRUCTURE AND REACTION KIN--ETC (U) DEC Al I M...solvent content (methylene chloride). DD I JAN73 1473 EDITION OF I NOV 65 IS OBSOLETE UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (When Doe Fntered

Mechanical Face Seal Dynamics.

DTIC Science & Technology

1985-12-01

1473, 83 APR EDITION OF I JAN 73 IS OBSOLETE. UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE -,1 - " P V 7 V - • ... f -N- PRE FACE This final...dimensionless mass m and support damping 1), ~ at-e aisas M"= -1,,i -4 4) y positive. ’he damping D is Ihe tinplete system of momeints acting on tile

Three-Dimensional Transient Natural Convection in a Horizontal Cylinder: A Numerical Analysis

DTIC Science & Technology

1980-02-01

A11D 03 _________ 14. MNITORNG AGNCY AME&AORESS(it different from Controlling Office) IS. SECURITY CLASS. (of this report) -~Th /UNCLASSIFIED AISa . OECL...method for the vorticity and - DD IjANඑ 1473 EDITION OF I NOV6 SS OBSOLETE UNCLASSIFIED SECURITY CLASSIFICATION Of THIS PACE,n bt. Nte, -’ ’..r&IeI

The Production and Destruction of Individual Competence: The Role of Vocational Experience

ERIC Educational Resources Information Center

Suleman, Fatima; Paul, Jean-Jacques

2007-01-01

This article presents the results of research into the impact on individual skill levels of the variables traditionally represented by human capital. The discussion is centred around the way in which education and vocational experience contribute to the process of producing useful skills in the job market or, conversely, of making them obsolete.…

REPORT ON THE PANEL SESSION: EMERGING ELECTRONICS ISSUES - HOW CAN WE MINIMIZE THE HEALTH AND ENVIRONMENTAL IMPACTS OF ELECTRONICS RECYCLING?

EPA Science Inventory

The production and use of electronic products is growing and the rapid pace at which the technology advances means that many electronic products become obsolete in a relatively short period of time. These factors are contributing to a growing challenge for waste management becaus...

Analytical Investigations of Bulk Wave Resonators in the Piezoelectric Thin Film on Gallium-Arsenide Configuration.

DTIC Science & Technology

1987-07-28

OPPICE SYMBOL (Inedu @ Ame Cadep Kevin J. Malloy 202-767-4931 NE DO FORM 1473, 83 APR EDITION OF I JAN 73 S OBSOLETE. Unclassified . ’ J P...Sitnce thle calculated Q is a very cuadshldbhiertnteatalQsbcuete rapdlyvaringfuntioi o th waer hicnes, clcuatins material Q and thle Q due to radiation

76 FR 28016 - El Paso Natural Gas Company; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-13

... Natural Gas Company; Notice of Application On April 26, 2011, El Paso Natural Gas Company (El Paso), P.O...) an application under section 7(b) of the Natural Gas Act (NGA) and Part 157.5 of the Commission's... Unit 2B since it has become functionally obsolete and is no longer needed to provide natural gas...

77 FR 44064 - Federal Acquisition Regulation: Clarification of Standards for Computer Generation of Forms

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... Federal Register at 73 FR 51276 on September 2, 2008, by the Department of Commerce. This FIPS requirement was withdrawn by the Secretary of Commerce because it was obsolete and had not been updated to adopt...) 12866 and 13563 direct agencies to assess all costs and benefits of available regulatory alternatives...

The Recoverability of P-Technique Factor Analysis

ERIC Educational Resources Information Center

Molenaar, Peter C. M.; Nesselroade, John R.

2009-01-01

It seems that just when we are about to lay P-technique factor analysis finally to rest as obsolete because of newer, more sophisticated multivariate time-series models using latent variables--dynamic factor models--it rears its head to inform us that an obituary may be premature. We present the results of some simulations demonstrating that even…

Chinese Mine Warfare: A PLA Navy Assassin’s Mace Capability (China MaritimeStudy, Number 3)

DTIC Science & Technology

2009-06-01

derived from obsolete tor- pedoes (e.g., earlier models of China’s Yu series) and launched from submarines, they travel along a user-determined course... video clip, originally at web.search.cctv .com, has been removed from the CCTV website. An image from the television footage has been posted on

Hölderlin's Idea of "Bildungstrieb": A Model from Yesteryear?

ERIC Educational Resources Information Center

Waibel, Violetta L.

2018-01-01

The term "Bildungstrieb", which was used toward the end of the eighteenth century by thinkers like Johann Gottfried Herder, Immanuel Kant, or Friedrich Schiller, but which is obsolete in today's vernacular, was of great importance for Friedrich Hölderlin. In this article, I explore the historical roots of this concept in the biology of…

High Schools on a Human Scale: How Small Schools Can Transform American Education.

ERIC Educational Resources Information Center

Toch, Thomas

This book argues that large American high schools have become obsolete and uses case studies of four new or restructured schools to show why smallness and distinctiveness are prerequisites for school reform. The large comprehensive high school developed as an economical means of providing a range of "tracks," from practical subjects for future…

77 FR 31182 - Final Withdrawal of Regulations Pertaining to Imports of Cotton Woven Fabric and Short Supply...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... No. 120117047-2421-02] RIN 0625-AA90 Final Withdrawal of Regulations Pertaining to Imports of Cotton... final rule withdrawing regulations pertaining to imports of cotton woven fabric and short supply procedures. Both sets of regulations are obsolete: The tariff quota on cotton woven fabric expired in 2009...

Universities and Industry: Does the Lambert Code of Governance Meet the Requirements of Good Governance?

ERIC Educational Resources Information Center

Buckland, Roger

2004-01-01

The Lambert Model Code of Governance proposes to institutionalise the dominance of governors from commercial and industrial organisations as core members of compact and effective boards controlling UK universities. It is the latest expression of a fashion for viewing university governance as an overly-simple example of an obsolete system, where…

Establishment of a Data Repository Establishment for Cognitive Modeling

DTIC Science & Technology

2012-09-02

was abandoning Flash in favor of HTML5 . The implications of this for CMR are that, although the submission pages will work fine for a couple of years...all browsers will continue to support flash for the time being), the software will eventually become obsolete. The sooner this part of CMR is rewritten in HTML5 , the better.

New Meets New: Fitting Technology to an Inquiry-Based Teacher Education Program.

ERIC Educational Resources Information Center

Jacobsen, D. Michele; Clark, W. Bruce

The method by which student teachers at the University of Calgary are prepared to meet technology requirements for teacher certification has been made obsolete by the introduction of a new inquiry-based teacher education program. Combined with a new school curriculum, which requires the seamless integration of technology into core subject areas,…

Coming of Age for the 21st Century.

ERIC Educational Resources Information Center

Hill, Paul, Jr.

Literature that speculates about the future omits African-Americans. Racism and unemployment have caused this group to swell the ranks of the underclass. Thus, as a group, blacks have been written off as obsolete and useless. Most at risk for joining the underclass is the black male. Because of the way Western males are socialized to be strong and…

The Training and Implementation of Project-Based Learning: A Phenomenological Study

ERIC Educational Resources Information Center

Vega, Adrian

2011-01-01

The state of public education in the first decade of the 21st century is at a crossroads. Unlike the challenges that have confronted public education in the past, public schools are faced with the possibility of becoming obsolete. With the rapid advances in technology, increased school choice via charter schools, home schooling, and virtual…

Professional Training of Social Workers: Development of Professionally Significant Qualities in the Future Social Workers

ERIC Educational Resources Information Center

Minzhanov, Nurlan A.; Ertysbaeva, Gaukhar N.; Abdakimova, Madina K.; Ishanov, Pirmagambet Z.

2016-01-01

Today, the traditional approach to professional training is obsolete. This problem has determined the need to create new didactic forms related to the organization of training in the modern education system. The purpose of this study was to analyze possible development of professionally important qualities and abilities in the future social care…

78 FR 61821 - Taking of Marine Mammals Incidental to Commercial Fishing Operations; Harbor Porpoise Take...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-04

...;Prices of new books are listed in the first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0... fishing closure that was based on an obsolete trigger to prevent unnecessary economic impacts from... of time for comment and allowed an expedient implementation of this final rule. Economic Impacts of...

77 FR 33063 - Selection and Functions of Farm Service Agency State and County Committees

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

...;Prices of new books are listed in the first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0... current practice and are largely unchanged from the current regulations. Obsolete references to... in use. Since the details are in the handbooks and directives, the provisions now reference the...

The Creative Classroom: The Role of Space and Place toward Facilitating Creativity

ERIC Educational Resources Information Center

Warner, Scott A.; Myers, Kerri L.

2010-01-01

As people become more sophisticated in their understanding of the workings of the human mind, it becomes increasingly clear that the processes of teaching and learning are more complex and subtle than was once thought. Models of education that were appropriate in the past are now obsolete. Cornell (2002) proposed an emerging paradigm of teaching…

The Rise of K-12 Blended Learning: Profiles of Emerging Models

ERIC Educational Resources Information Center

Staker, Heather

2011-01-01

Some innovations change everything. The rise of personal computers in the 1970s decimated the mini-computer industry. TurboTax forever changed tax accounting, and MP3s made libraries of compact discs obsolete. These innovations bear the traits of what Harvard Business School Professor Clayton M. Christensen terms a "disruptive innovation."…

77 FR 26025 - Notice of Intent To Prepare a Environmental Impact Statement (EIS) for the HOPE SF Development at...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

.... Surrounding land uses include residential, commercial, recreational, and industrial uses. To the north and... School. To the south are industrial uses. Across Texas Street to the east are multi-family residential, single-family residential, and industrial uses. The obsolete buildings that make up the site are in need...

'When in Doubt, Preserve': Exploring the Traces of Teaching and Material Culture in English Schools.

ERIC Educational Resources Information Center

Lawn, Martin; Grosvenor, Ian

2001-01-01

Ponders questions arising from items of obsolete technology found stored in an obscure part of the Prince Albert Junior and Infant School, Aston, Birmingham (England) school building. Explores how historical debris can bring the past into the present to provide insight into past teacher experiences, working practices, and culture. (MER)

76 FR 47436 - Virginia Graeme Baker Pool and Spa Safety Act; Incorporation by Reference of Successor Standard

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

.... Ultraviolet Light Exposure Test The Ultraviolet Light Exposure Test (UV test) subjects the plastic drain....'' ANSI/ASME A112.19.8-2007 indicates that ``cover'' is an obsolete term.) Tests for the structural.... The structural integrity tests subject the drain fitting to forces expected under normal use and to...

The (Mis)Use of Technology in the National Accreditation System

ERIC Educational Resources Information Center

Munson, April

2014-01-01

The use of technology in the evaluation of higher education programs is a mainstay. Physical evidence rooms, face-to-face interviews, and reviewing of documentation on site have become obsolete. Relying on the heavy use of technology in the evaluation process has allowed what some believe to be a more cohesive, streamlined approach to the…

China Report, Economic Affairs

DTIC Science & Technology

1986-04-09

improve the quality of goods for export. Jinan Knitwear Mill imported advanced technology to replace obsolete equipment and raised product quality...concentrating their strength on improving technology and developing social productive forces, fully developing their own strong points and running...Discovered in Qinghai 44 INDUSTRY Fashion Design Booming Industry in China (XINHUA, 17 Mar 86) 45 b - Anhui Raw Materials Development

Through Efficient Use of LORs: Prospective Teachers' Views on Operational Aspects of Learning Object Repositories

ERIC Educational Resources Information Center

Yalcinalp, Serpil; Emiroglu, Bulent

2012-01-01

Although many developments have been made in the design and development of learning object repositories (LORs), the efficient use of such systems is still questionable. Without realising the functional use of such systems or considering the involvement of their dynamic users, these systems would probably become obsolete. This study includes both…

Kindling: The Amazon e-Reader as an Educational Tool

ERIC Educational Resources Information Center

Brezicki, Colin

2011-01-01

The revolutionary electronic reading device, Amazon's Kindle, is already obsolete. Such is the breakneck speed of technology that the machine touted to spell the death of printed books is already heading for the scrap heap, replaced by e-readers like the iPad that access the Internet, make phone calls, download movies, and connect users with all…

Is the Office Hour Obsolete?

ERIC Educational Resources Information Center

Behrens, Susan

2013-01-01

A colleague can't make a coffee date at a time the author proposes because it would conflict with his office hour. No student has actually made an appointment with him during the hour, but he is committed to being in his office as promised in case someone drops by. The author's reaction to her colleague's faithfulness to his posted office hour…

Education and the Role of the Educator in the Future

ERIC Educational Resources Information Center

Jukes, Ian; McCain, Ted; Crockett, Lee

2011-01-01

Exponential change is making our education system obsolete. New inventions will replace not only textbooks, but everything we currently think of as school. Teachers will need to rethink their roles as advances in teaching machines allow lessons to be customized to every child wherever that child might be. What is taught also will change because…

TA 55 Reinvestment Project II Phase C Update Project Status May 23, 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giordano, Anthony P.

The TA-55 Reinvestment Project (TRP) II Phase C is a critical infrastructure project focused on improving safety and reliability of the Los Alamos National Laboratory (LANL) TA-55 Complex. The Project recapitalizes and revitalizes aging and obsolete facility and safety systems providing a sustainable nuclear facility for National Security Missions.

WATER PUMP HOUSE, TRA619, PUMP INSTALLATION. CAMERA FACING NORTHEAST CORNER. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

WATER PUMP HOUSE, TRA-619, PUMP INSTALLATION. CAMERA FACING NORTHEAST CORNER. CARD IN LOWER RIGHT WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON THE ORIGINAL NEGATIVE. INL NEGATIVE NO. 3998. Unknown Photographer, 12/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

The Past and Likely Future of an Educational Form: A Textbook Case

ERIC Educational Resources Information Center

Friesen, Norm

2013-01-01

At a time when it is seen as increasingly "obsolete," this article analyzes the textbook as an evolving pedagogical form, as a changing medium comprised of smaller media components. These components include images, diagrams and also oral prompts, which have changed not so much through technical innovation as in synchrony with larger…

Using the CREW Method to Enhance Public and School Library Collections

ERIC Educational Resources Information Center

Boon, Belinda

2009-01-01

Now, more than ever, public and school libraries struggle to main- tain their relevance in the age of instant access, electronic databases, and Google. While print collections continue to grow, many collections are drowning in obsolete, unused, and unwanted materials. And while most libraries keep up with deselection in an intelligent manner, many…

Not for Bread Alone: An Appreciation of Job Enrichment.

ERIC Educational Resources Information Center

Taylor, Linda King

Bridging the gap between theory and practice, the author through a case-study approach of industries in the United Kingdom and Europe has identified motivation techniques resulting in job enrichment. The book is written in the belief that work is more efficient when it is enjoyable and that human beings will become obsolete unless allowed to…

Expanding Roles and Resources: Assessing the Collaboration between Florida Atlantic University Libraries and Taras Oceanographic Foundation

ERIC Educational Resources Information Center

Arrieta, Diane; Brunnick, Barbara; Plocharczyk, Leah

2015-01-01

As academic libraries struggle to remain relevant when technological advancements and electronic resources threaten to make them obsolete, libraries are learning to re-invent themselves by molding and adapting staff skills to cultivate innovative outreach programs. The Science Outreach Committee of the John D. MacArthur Campus library at Florida…

77 FR 313 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-04

... Change Deleting NYSE Arca Equities Rule 7.31(w)(1) to Remove the PNP Plus Order Type December 28, 2011... Equities Rule 7.31(w)(1) to remove the PNP Plus Order type. The text of the proposed rule change is...(w)(1) to remove the PNP (Post No Preference) Plus order type. By its terms, a PNP Order is a limit...

Regional Studies with Broadband Data.

DTIC Science & Technology

1988-05-15

1473,83 APR EDITION OF 1 JAN 73 IS OBSOLETE liny]a=Q fiPd SECURITY CLASSIFICATION OF THIS PAGE Unclassified SECURITY CLASSIFICATION OF THIS PAGE deep Bonin ...8 Tests with Synthetic Data............................................. 9 Results for the Bonin island Earthquake...Seis- mic Network to estimate the isotropic part of the moment tensor of a deep Bonin Islands earthquake. Modelling indicates that more than 10% of

A bill to repeal an obsolete provision in title 49, United States Code, requiring motor vehicle insurance cost reporting.

THOMAS, 112th Congress

Sen. Klobuchar, Amy [D-MN

2012-12-04

Senate - 12/04/2012 Read twice and referred to the Committee on Commerce, Science, and Transportation. (All Actions) Notes: For further action, see H.R.5859, which became Public Law 112-252 on 1/10/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Disrupting the old order of imaging.

PubMed

Jha, Saurabh; Lexa, Frank J

2013-06-01

The purpose of this article is to expand on the economic concepts of creative destruction and disruptive innovation to imagine scenarios in which diagnostic imaging modalities and certain imaging paradigms can be rendered obsolete. Potential disrupters of imaging are novel drugs, clinical trials, accurate biomarkers, and government regulations. A taxonomic schema can be used to better predict the decline of certain imaging modalities.

Helping Put Technology into Classrooms for Less Than a Penny a Day.

ERIC Educational Resources Information Center

Kaelin, Elmer

This paper argues that: (1) technology with its ability to individually tutor each child has rendered the blackboard classroom based on group teaching obsolete; (2) state leaders must provide the initiatives it will take for America to make the transition to the technology-driven classroom by the year 2000; and (3) a significant portion of the…

Final Tactical Decision Aid (FTDA) for Infrared (8-12 Micrometers) Systems - Manual Version. Volume II. Appendix A. Atmospheric Transmission Tables,

DTIC Science & Technology

1982-09-15

OBSOLETE UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (When Date Efntee -- - -- I I New SSD-T-8-6061-007 (1I)-82 TABLE OF CONTENTS 1. A Brief...possible transformation of airmasses with a continntal origin so that their aerosol asames the extinction properties of a maritime aerosol. Figure A-IB

The Plus 50 Population in Higher Education: Challenges and Triumphs

ERIC Educational Resources Information Center

Barr, Jason

2016-01-01

As the economy in the United States continues to emerge from a recession and as jobs become more technologically advanced rendering other jobs obsolete, more and more Americans over the age of 50 are now attending college for a variety of reasons. Around 77% of the so-called Plus 50 students were enrolled in two-year public institutions. Other…

"Now, Year Ones, This Is Your Life!" Preparing the Present Generation of Students for a World of Shrinking Distances.

ERIC Educational Resources Information Center

Beare, Hedley

2001-01-01

Forecasts for the future are made against the backdrop of population growth, environmental change, information technology, and globalization. Schools and teachers as we know them will change radically, perhaps become obsolete, as computers and the Internet enable access to information from anywhere, any time. Learning will become a life-long,…

The Speed of Obsolescence: Evidence from the Dutch Public Sector

ERIC Educational Resources Information Center

van Loo, Jasper B.

2007-01-01

HRD is extensively concerned with human capital investment, but only focuses on how skills and knowledge become obsolete to a limited extent. In this paper we look at the speed of obsolescence. Using data from a survey among Dutch public sector employees, we find that the yearly rate of skills obsolescence is 2.6%. Subsequent analyses show that…

78 FR 49685 - Approval and Promulgation of Air Quality Implementation Plans; State of Wyoming; Revised General...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-15

..., particulate matter (PM), and sulfur dioxide (SO 2 ). Because certain provisions of section 176(c) of the CAA...), ``Prohibition'', was modified to remove obsolete provisions in (a)(iii) and now makes this section reserved. 2. Section 3(a), ``Prohibition'', was modified to define NEPA in (a)(iv) and to add a new section (v) that...

Virtual Reality

DTIC Science & Technology

1993-04-01

until exhausted. SECURITY CLASSIFICATION OF THIS PAGE All other editions are obsolete. UNCLASSIFIED " VIRTUAL REALITY JAMES F. DAILEY, LIEUTENANT COLONEL...US" This paper reviews the exciting field of virtual reality . The author describes the basic concepts of virtual reality and finds that its numerous...potential benefits to society could revolutionize everyday life. The various components that make up a virtual reality system are described in detail

Reproductive endocrinology and infertility fellowships: is the 'reproductive endocrinology' portion obsolete?

PubMed

Omurtag, Kenan; Lebovic, Dan I

2015-08-01

To take inventory of the past and present and project the future direction of our field to help train the next generation of providers. Review the history of the subspecialty and factors contributing to its evolution. Reproductive endocrinology and infertility's in-vitro fertilization future is shaping the intellectual priorities and surgical skill requirements of the next generation.

Canada Basin Acoustic Propagation Experiment (CANAPE)

DTIC Science & Technology

2015-09-30

1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Canada Basin Acoustic Propagation Experiment (CANAPE...ocean structure. Changes in sea ice and the water column affect both acoustic propagation and ambient noise. This implies that what was learned...about Arctic acoustics during the Cold War is now obsolete. The goal of the Canada Basin Acoustic Propagation Experiment (CANAPE) is to determine the

Women in Combat: Is the Current Policy Obsolete

DTIC Science & Technology

2007-02-23

gender issues were cited by fewer than 1 percent of their respondents when asked about issues that affect morale in recently gender -integrated units...37 GENDER ISSUES /POLICIES THAT EFFECT MILITARY CAPABILITY..................42 Pregnancy... Gender Issues ,” Report No. GAO/NSAID-99-7, 19 October 1998, p. 4. 2 personal experiences as a combat pilot and military commander frame my

National Weather Service will stop using all caps in its forecasts |

Science.gov Websites

lines. Teleprinters only allowed the use of upper case letters, and while the hardware and software used not for lack of trying. The National Weather Service has proposed to use mixed-case letters several times since the 1990s, when widespread use of the Internet and email made teletype obsolete. In fact, in

Mice Overexpressing Type 1 Adenylyl Cyclase Show Enhanced Spatial Memory Flexibility in the Absence of Intact Synaptic Long-Term Depression

ERIC Educational Resources Information Center

Zhang, Ming; Wang, Hongbing

2013-01-01

There is significant interest in understanding the contribution of intracellular signaling and synaptic substrates to memory flexibility, which involves new learning and suppression of obsolete memory. Here, we report that enhancement of Ca[superscript 2+]-stimulated cAMP signaling by overexpressing type 1 adenylyl cyclase (AC1) facilitated…

Does Philosophy Still Deserve a Special Role in Catholic Higher Education?

ERIC Educational Resources Information Center

Bassham, Gregory

2015-01-01

This paper (1) explores the reasons why philosophy was accorded a special role in Catholic higher education in the United States in the decades prior to Vatican II; (2) explains why many of those reasons are now widely seen as attenuated or obsolete; (3) briefly discusses recent changes to the environment of Catholic higher education that have led…

Report of Secretary of Defense, Caspar W. Weinberger, to the Congress on the FY 1983 Budget, FY 1984 Authorization Request and FY 1983-1987 Defense Programs.

DTIC Science & Technology

1982-02-08

although non-aligned, Malaysia , Indonesia, and Singapore support U.S. presence in South- east Asia and allow unhampered U.S. transit of the vital...modernization of obsolete facilities, maintenance of existing facilities, energy conservation, compliance with environmental and OSHA stan- dards, and NATO

XNDM: An Experimental Network Data Manager.

DTIC Science & Technology

1981-06-01

return this copy. Retain or destroy. t t , UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE fWln Dtet Entred) READ INSTRUCTIONSREPORT DOCUMENTATION...MONITORING AGENCY NAME & AODRESS(IE’ different Irom Controlling Office) 15 SECURITY CLASS, (I this report) UNCLASSIFIED Same Is DECLASSIFICATION...DD JAN% 1473 EDITION OF I NOV 65 IS OBSOLETE UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE ("hen Date Entered) -: o . <. UNCLASSIFIED SECURITY

Just Because You Can Doesn't Mean You Should

ERIC Educational Resources Information Center

Fiehn, Barbara

2016-01-01

When was the last time you saw a student copying from a print reference source? As print sources gather dust, digital materials' use grows. Digital materials are more to the liking of students raised with technology in hand. For young learners, the process of on-screen copy and paste has made replication with pen and paper obsolete. As digital…

Revisiting Mathematical Problem Solving and Posing in the Digital Era: Toward Pedagogically Sound Uses of Modern Technology

ERIC Educational Resources Information Center

Abramovich, S.

2014-01-01

The availability of sophisticated computer programs such as "Wolfram Alpha" has made many problems found in the secondary mathematics curriculum somewhat obsolete for they can be easily solved by the software. Against this background, an interplay between the power of a modern tool of technology and educational constraints it presents is…

Synthesis of Mismatched Heterojunction/Substrate Interfaces

DTIC Science & Technology

1991-10-11

and advantages of strained layers. DD IZ JAN7 1473 EDITION OF INOV 65 IS OBSOLETE *’~~s.*. ~ ~.-A ~’ SECURITY CLASSIFICATIO14 Ol THIS PAGE (When Dsea...cross-section is shown ini 1-ig. 1.14(a), is analogous to the polysilicon -gate FET in Si-MOS devices. From the band diagam in Fig 1.14(b), it can be seen

Tacit Knowledge and General Qualification: Concepts of Learning in Everyday Life and Formal Education When Work Changes with Examples from Office Work.

ERIC Educational Resources Information Center

Olesen, Henning Salling

An analysis of office work (OW) highlights the relationship between formal vocational qualifications and tacit knowledge gained through experience. In OW, "abstracted" skills (typewriting, correspondence) and theory are taught in schools out of their practical context and can become obsolete because of technological change. Some types of…

SRI PUFF 8 Computer Program for One-Dimensional Stress Wave Propagation

DTIC Science & Technology

1980-03-01

raial product. UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (Tfhen Data Entered) REPORT DOCUMENTATION PAGE READ INSTRUCTIONS BEFORE COMPLETING...EDITION OF I NOV 6S (S OBSOLETE UNCLASSIFIED SECURITY CLASSIFICATIOK OF THIS PAGE (When Data Entered) UNCLASSIFIED SECURITY CLASSIFICATION OF THIS...aspects of wave propagation calculations. UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGEfWhen Data Entered) FOREWORD This volume constitutes a

Research on Near Field Pattern Effects.

DTIC Science & Technology

1981-01-01

block numbr) High frequency solutions Prolate spheroid mounted antennas Uniform Geometrical Theory of Diffraction Airborne antenna pattern predicti...Geometrical Theory of Diffraction solutions which were developed previously were DD 1473 EDITION OF I NOV 66 IS OBSOLETE UCASFE SECURITY CLASSIFICATION...be used later to simulate the fuselage of a general aircraft. The general uniform Geometrical Theory of Diffraction (GTD) solutions [1i which are

75 FR 49849 - Defense Federal Acquisition Regulation Supplement; Excessive Pass-Through Charges (DFARS Case...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

..., and specifications; (2) Work itemized; (3) Place of performance of the work; (4) Time of commencement or completion of the work; and (5) Any other requirement of the job order. (b) If a change causes an... property made obsolete or excess as a result of a change, the Contracting Officer shall have the right to...

Rational Rationing: Impossible or Inevitable?

DTIC Science & Technology

1993-04-01

AD-A276 769 1993 Executive Research Project S45 Rational Rationing : Impossible or Inevitable? Commander Albert Benjamin Long, III Medical Service...used until exhausted. SECURITY CLASSIFICATION OF THIS PAGE All other editions are obsolete. UNCLASSIFIED Rational Rationing : Inevitable or Inpossible...dilemma requires that we--as individuals and as a Nation--consciously and rationally decide what we expect from our future health care delivery system and

Lessons from the UK Know How Funds Initiative: Development of Peer Education for Business in Emergent Market Economies

ERIC Educational Resources Information Center

Morrison, A.

2003-01-01

The relationship that has existed historically between industry and higher education in Western economies is currently being mirrored in the transforming economies of the former Soviet Union. These emerging market economies have been encouraged by their association with a now obsolete British Council awards scheme to study historical and current…

Demonstration Results for the Phytoextraction of Lead-Contaminated Soil at the Twin Cities Army Ammunition Plant, Arden Hills, Minnesota

DTIC Science & Technology

2000-07-01

and leachate collection prior to approval of future phytoextraction at sites such as this. Lead Phytoremediation Demonstration 8-1...number) FIELD GROUP SUB-GROUP Phytoremediation of Lead-Contaminated Soil 19. ABSTRACT (Continue on reverse if necessary and identify by block number...editions are obsolete SECURITY CLASSIFICATION OF THIS PAGE Lead Phytoremediation Demonstration

Using natural language processing to analyze physician modifications to data entry templates.

PubMed Central

Wilcox, Adam B.; Narus, Scott P.; Bowes, Watson A.

2002-01-01

Efficient data entry by clinicians remains a significant challenge for electronic medical records. Current approaches have largely focused on either structured data entry, which can be limiting in expressive power, or free-text entry, which restricts the use of the data for automated decision support. Text-based templates are a semi-structured data entry method that has been used to assist physicians in manually entering clinical notes, by allowing them to edit predefined example notes. We analyzed changes made to 18,726 sentences from text templates, using a natural language processor. The most common changes were addition or deletion of normal observations, or changes in certainty. We identified common modifications that could be captured in structured form by a graphical user interface. PMID:12463955

Analysis of repeat-mediated deletions in the mitochondrial genome of Saccharomyces cerevisiae.

PubMed

Phadnis, Naina; Sia, Rey A; Sia, Elaine A

2005-12-01

Mitochondrial DNA deletions and point mutations accumulate in an age-dependent manner in mammals. The mitochondrial genome in aging humans often displays a 4977-bp deletion flanked by short direct repeats. Additionally, direct repeats flank two-thirds of the reported mitochondrial DNA deletions. The mechanism by which these deletions arise is unknown, but direct-repeat-mediated deletions involving polymerase slippage, homologous recombination, and nonhomologous end joining have been proposed. We have developed a genetic reporter to measure the rate at which direct-repeat-mediated deletions arise in the mitochondrial genome of Saccharomyces cerevisiae. Here we analyze the effect of repeat size and heterology between repeats on the rate of deletions. We find that the dependence on homology for repeat-mediated deletions is linear down to 33 bp. Heterology between repeats does not affect the deletion rate substantially. Analysis of recombination products suggests that the deletions are produced by at least two different pathways, one that generates only deletions and one that appears to generate both deletions and reciprocal products of recombination. We discuss how this reporter may be used to identify the proteins in yeast that have an impact on the generation of direct-repeat-mediated deletions.

Analysis of Repeat-Mediated Deletions in the Mitochondrial Genome of Saccharomyces cerevisiae

PubMed Central

Phadnis, Naina; Sia, Rey A.; Sia, Elaine A.

2005-01-01

Mitochondrial DNA deletions and point mutations accumulate in an age-dependent manner in mammals. The mitochondrial genome in aging humans often displays a 4977-bp deletion flanked by short direct repeats. Additionally, direct repeats flank two-thirds of the reported mitochondrial DNA deletions. The mechanism by which these deletions arise is unknown, but direct-repeat-mediated deletions involving polymerase slippage, homologous recombination, and nonhomologous end joining have been proposed. We have developed a genetic reporter to measure the rate at which direct-repeat-mediated deletions arise in the mitochondrial genome of Saccharomyces cerevisiae. Here we analyze the effect of repeat size and heterology between repeats on the rate of deletions. We find that the dependence on homology for repeat-mediated deletions is linear down to 33 bp. Heterology between repeats does not affect the deletion rate substantially. Analysis of recombination products suggests that the deletions are produced by at least two different pathways, one that generates only deletions and one that appears to generate both deletions and reciprocal products of recombination. We discuss how this reporter may be used to identify the proteins in yeast that have an impact on the generation of direct-repeat-mediated deletions. PMID:16157666

77 FR 73106 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-07

... Amending Rule 123C(9)(a)(1)(ii)--Equities To Delete the Requirement That the Order Acceptance Cut-Off Time... order acceptance cut-off time cannot be past 4:30 p.m. The text of the proposed rule change is available... acceptance cut-off time cannot be past 4:30 p.m. (or 30 minutes after the scheduled close in the case of an...

Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells*♦

PubMed Central

Canver, Matthew C.; Bauer, Daniel E.; Dass, Abhishek; Yien, Yvette Y.; Chung, Jacky; Masuda, Takeshi; Maeda, Takahiro; Paw, Barry H.; Orkin, Stuart H.

2014-01-01

The clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 nuclease system has provided a powerful tool for genome engineering. Double strand breaks may trigger nonhomologous end joining repair, leading to frameshift mutations, or homology-directed repair using an extrachromosomal template. Alternatively, genomic deletions may be produced by a pair of double strand breaks. The efficiency of CRISPR/Cas9-mediated genomic deletions has not been systematically explored. Here, we present a methodology for the production of deletions in mammalian cells, ranging from 1.3 kb to greater than 1 Mb. We observed a high frequency of intended genomic deletions. Nondeleted alleles are nonetheless often edited with inversions or small insertion/deletions produced at CRISPR recognition sites. Deleted alleles also typically include small insertion/deletions at predicted deletion junctions. We retrieved cells with biallelic deletion at a frequency exceeding that of probabilistic expectation. We demonstrate an inverse relationship between deletion frequency and deletion size. This work suggests that CRISPR/Cas9 is a robust system to produce a spectrum of genomic deletions to allow investigation of genes and genetic elements. PMID:24907273

Appendix C: Rapid development approaches for system engineering and design

NASA Technical Reports Server (NTRS)

1993-01-01

Conventional system architectures, development processes, and tool environments often produce systems which exceed cost expectations and are obsolete before they are fielded. This paper explores some of the reasons for this and provides recommendations for how we can do better. These recommendations are based on DoD and NASA system developments and on our exploration and development of system/software engineering tools.

High Efficiency Transverse D. C. Electron Beams.

DTIC Science & Technology

1984-10-01

22c. OFFICE SYM yer(Include A 4VCode, 01’ e, V.2 DD FORM 1473, 83 APR’ EDITION OF I JAN 73 IS OBSOLETE. " * . TCUIV ( 4 tUIFICATION OF THIS PAGE This...Reflectivities were R, -> 99.17 (FI 2 Laser output rxtwer ofthe 6 149 9-A fig I I iransition aisa function of and ~ 935% a 4 0 A.Usin thi laer stup

Shipbuilding and Conversion, Navy, (SCN) Funds Flow for Major Shipbuilding Programs

DTIC Science & Technology

1975-05-01

Idenlty by bloc,. number) SEE ATTACHED SHEET D IAM 1473 EDITION OF I NOV 65 I OBSOLETE SECURITY CLASSIFICATI(Y’ OF THIS PAGE (Whaen Data Lnter..d...A C CEPTRJCE gTA; see foe*s aisa odstiens oe r usifeetey ,..d ~.ect"lJJ I AC -TitU OfIC11 (roe mov ox tite) . fIiNATUMI 40 ~I- MILITARY

Quadrature-Quadrature Phase Shift Keying.

DTIC Science & Technology

1986-09-01

SECURITY CLASSIFICATION OF -IS PAfr All other editions are obsolete ’r- Ac P..N -N- %.. .. V . .. b . h S Debabrata Saha 1986 All Rights Reserved...1.2/T T~,pe of AISA Q -PSK AMSK 0 Y(IitIo ?6 orthogonal Four -level F, J." 𔃻 1i 1/ 2 H13.4 a H P6 E 44 3.5 Modulator Demodulator and Synchronization

78 FR 66840 - Revocation of Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-07

... Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns Not Intended for Use... regulations pertaining to caps intended for use with toy guns refer to obsolete equipment, but the ASTM F963... revokes the existing regulations pertaining to caps intended for use with toy guns and toy guns not...

Development of a Naval Supply Systems Command Acquisition Supplement - A Business Practice Improvement

DTIC Science & Technology

2015-09-01

The information reviewed for this project will help the reader understand how acquisition rules and regulations flow down to the acquisition...ACQUISITIONS IN SUPPORT OF OPERATIONS IN AFGHANISTAN Aug-09 N Obsolete 09-26 PASSIVE RADIO FREQUENCY IDENTIFICATION ( RFID ) DFARS COMPLIANCE REPORTING...been made. Many of the instructions and publications refer readers to additional instructions and publications, and often reference specific policy

OM85. Basic Properties of Optical Materials Summaries of Papers.

DTIC Science & Technology

1985-05-01

NUMBER 22c. OFF ICE SYMBOL * KEVIN J MALLOY, Capt, USAF (U)b-JINE 7 DD FORM 1473, 83 APR EDITION OF I JAN 73 IS OBSOLETE. UNCLASSIFIED SECURITY...COL, WAVELENGh (1984) 7 urn the absorption of waer -la utsetrlZShsbe reucd y bo25 ties tis no2 inrisi in th78t WAVENGTHE (m) bee rdued y ve 10 100 i

National Dam Safety Program. MO Noname 27 Dam (MO 10353), Missouri - Nemaha - Nodaway Basin, Holt County, Missouri. Phase I Inspection Report.

DTIC Science & Technology

1979-05-01

life or property. OFl1473 EDTIOM Of I NOV 6S IS OBSOLETE .1 -CA FW IAN "’n.... UNCI.ASSTFTR~n ,SECURITY CLASSIFICATION OF THIS PAGE (When Data Entered...data were developed from the USGS Maitland , Missouri 15 minute topographic quadrangle map. The hydraulic computations for the spillway and dam

Acquisition Modernization: Transitioning Technology Into Warfighter Capability

DTIC Science & Technology

2011-08-01

to test and evaluate the technology and integrate the new capability into operational weapon systems (Figure 4). This funding model creates stove...misalignment between missions, TRLs, and the RDT&E funding model is a major 11 contributor to the valley of death. Technologies become obsolete on... funding model of the acquisition system. Create an individual budget account to fund the development of promising technologies. The Acquisition

A Better Safety Net: It's Time to Get Smart about Online Safety

ERIC Educational Resources Information Center

Collier, Anne

2009-01-01

Online safety is obsolete. A concept little changed since the 1990s, it's one size fits all, emphasizing fear instead of facts, with young people stereotyped as potential victims in a hostile media environment. It's past time for Online Safety 3.0. Why 3.0? Previous versions--1.0 and 2.0--focused on inappropriate content, adult-to-child crime, and…

The Goal of Motivation in the Military. Soldier Satisfaction or Soldier Performance

DTIC Science & Technology

1978-06-09

soldier’s (E- 1 through E-,4) perceptions of 18 job-related factors, his/her level of performance and-" FOR" 1473 EDfTON Or I NOV 65 Is OBSOLETE UJCLAS...iv LIST OF FIGURES . . . . . . . . . . . . . . . . . . . . . . . . v CHAPTER 1 . THE PROBLEM AND ITS SETTING . ..... ....... .... 1 INTRODUCTION...81 RECOMKM•DATION .83. , . * 3 SELECTED BIBLIOGRAPHY . . . . . . . . . . .......... . . 84 liii LIST OF TABLES Table Page 1

Competitive Strategies

DTIC Science & Technology

1988-05-27

Competitive Strategies Individual Essay 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(@) S. CONTRACT OR GRANT NUMBER( e ) Robert M. Davis, LTC, AD S...DO FOe 1473 emIotN or, Nov es IS OBSOLETE -JA I Unclassifi fed SECURITY CLASSIFICATION OF THIS PA7. E (Whrn Does Entered) Unclassified SECURITY...focus within the Department of Defense to provide technical and tactical leverage over the Soviets. Competitive Strategies are a management tool which

Artillery Employment at the Battle of Gettysburg

DTIC Science & Technology

1989-06-02

ARTILLERY EMPLOYMENT AT THE BATTLE OF GETTYSBURG A thesis presented to the Faculty of the U.S. Army Command and General Staff College in partial...ISPONSORING 18b. OFFICE SYMBOL 9. PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER ORGANIZATION (f aplicable ) Sk. ADDRESS (City, State, and ZIP Code) 10...editions are obsolete. SECURITY CLASSIFICATION OF THIS PAGE UNCLASSIFIED 19. ABSTRACT This thesis is an historical analysis of the Union artillery at

DEMINERALIZER BUILDING, TRA608. INSTALLATION OF SAMPLING AND OTHER INSTRUMENTS COMPLETES ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DEMINERALIZER BUILDING, TRA-608. INSTALLATION OF SAMPLING AND OTHER INSTRUMENTS COMPLETES DEMINERALIZER UNITS ALONG NORTH WALL. CAMERA FACES EAST. CARD IN LOWER RIGHT WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON THE ORIGINAL NEGATIVE. INL NEGATIVE NO. 3996A. Unknown Photographer, 12/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

MTR WING, TRA604. A LABORATORY ROOM WITH ITS CABINETS AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

MTR WING, TRA-604. A LABORATORY ROOM WITH ITS CABINETS AND SERVICE STRIP DOWN CENTER OF ROOM. CARD IN LEFT CORNER OF VIEW WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON THE ORIGINAL NEGATIVE. INL NEGATIVE NO. 3817. Unknown Photographer, 11/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Unitary Suprathreshold Color-Difference Metrics of Legibility for CRT Raster Imagery.

DTIC Science & Technology

1986-09-01

observers possessing norma vision could accurately read random numeral strings of one color displayed DD J 4-73 EDITION OF C 6S IS OBSOLETE - SEURT CLSIICTO...34 Table 2, continued. SAE (L*,u*,v*) : .909 .940 Intercept 1. 8581 1. 8022 " N -0. 3980 -0.3655 m .AE 0. 1217 0. 1206-" =, E -0. 0019 -0. 0017 * all t > 3

The Daily Disciplines of Leadership: How To Improve Student Achievement, Staff Motivation, and Personal Organization. The Jossey-Bass Education Series.

ERIC Educational Resources Information Center

Reeves, Douglas B.

This guide is intended to be a practical primer to help education leaders meet the daily challenges of school leadership. It shows how to include leadership in an integrated system of educational accountability, teaching, and curriculum for student achievement; how to do away with ineffective, obsolete, and unnecessary practices; and how to…

Hirsch index and truth survival in clinical research.

PubMed

Poynard, Thierry; Thabut, Dominique; Munteanu, Mona; Ratziu, Vlad; Benhamou, Yves; Deckmyn, Olivier

2010-08-06

Factors associated with the survival of truth of clinical conclusions in the medical literature are unknown. We hypothesized that publications with a first author having a higher Hirsch' index value (h-I), which quantifies and predicts an individual's scientific research output, should have a longer half-life. 474 original articles concerning cirrhosis or hepatitis published from 1945 to 1999 were selected. The survivals of the main conclusions were updated in 2009. The truth survival was assessed by time-dependent methods (Kaplan Meier method and Cox). A conclusion was considered to be true, obsolete or false when three or more observers out of the six stated it to be so. 284 out of 474 conclusions (60%) were still considered true, 90 (19%) were considered obsolete and 100 (21%) false. The median of the h-I was=24 (range 1-85). Authors with true conclusions had significantly higher h-I (median=28) than those with obsolete (h-I=19; P=0.002) or false conclusions (h-I=19; P=0.01). The factors associated (P<0.0001) with h-I were: scientific life (h-I=33 for>30 years vs. 16 for<30 years), -methodological quality score (h-I=36 for high vs. 20 for low scores), and -positive predictive value combining power, ratio of true to not-true relationships and bias (h-I=33 for high vs. 20 for low values). In multivariate analysis, the risk ratio of h-I was 1.003 (95%CI, 0.994-1.011), and was not significant (P=0.56). In a subgroup restricted to 111 articles with a negative conclusion, we observed a significant independent prognostic value of h-I (risk ratio=1.033; 95%CI, 1.008-1.059; P=0.009). Using an extrapolation of h-I at the time of article publication there was a significant and independent prognostic value of baseline h-I (risk ratio=0.027; P=0.0001). The present study failed to clearly demonstrate that the h-index of authors was a prognostic factor for truth survival. However the h-index was associated with true conclusions, methodological quality of trials and positive predictive values.

Gr/gr deletions on Y-chromosome correlate with male infertility: an original study, meta-analyses, and trial sequential analyses

NASA Astrophysics Data System (ADS)

Bansal, Sandeep Kumar; Jaiswal, Deepika; Gupta, Nishi; Singh, Kiran; Dada, Rima; Sankhwar, Satya Narayan; Gupta, Gopal; Rajender, Singh

2016-02-01

We analyzed the AZFc region of the Y-chromosome for complete (b2/b4) and distinct partial deletions (gr/gr, b1/b3, b2/b3) in 822 infertile and 225 proven fertile men. We observed complete AZFc deletions in 0.97% and partial deletions in 6.20% of the cases. Among partial deletions, the frequency of gr/gr deletions was the highest (5.84%). The comparison of partial deletion data between cases and controls suggested a significant association of the gr/gr deletions with infertility (P = 0.0004); however, the other partial deletions did not correlate with infertility. In cohort analysis, men with gr/gr deletions had a relatively poor sperm count (54.20 ± 57.45 million/ml) in comparison to those without deletions (72.49 ± 60.06), though the difference was not statistically significant (p = 0.071). Meta-analysis also suggested that gr/gr deletions are significantly associated with male infertility risk (OR = 1.821, 95% CI = 1.39-2.37, p = 0.000). We also performed trial sequential analyses that strengthened the evidence for an overall significant association of gr/gr deletions with the risk of male infertility. Another meta-analysis suggested a significant association of the gr/gr deletions with low sperm count. In conclusion, the gr/gr deletions show a strong correlation with male infertility risk and low sperm count, particularly in the Caucasian populations.

The dependence of frequency distributions on multiple meanings of words, codes and signs

NASA Astrophysics Data System (ADS)

Yan, Xiaoyong; Minnhagen, Petter

2018-01-01

The dependence of the frequency distributions due to multiple meanings of words in a text is investigated by deleting letters. By coding the words with fewer letters the number of meanings per coded word increases. This increase is measured and used as an input in a predictive theory. For a text written in English, the word-frequency distribution is broad and fat-tailed, whereas if the words are only represented by their first letter the distribution becomes exponential. Both distribution are well predicted by the theory, as is the whole sequence obtained by consecutively representing the words by the first L = 6 , 5 , 4 , 3 , 2 , 1 letters. Comparisons of texts written by Chinese characters and the same texts written by letter-codes are made and the similarity of the corresponding frequency-distributions are interpreted as a consequence of the multiple meanings of Chinese characters. This further implies that the difference of the shape for word-frequencies for an English text written by letters and a Chinese text written by Chinese characters is due to the coding and not to the language per se.

The prevalence of chromosomal deletions relating to developmental delay and/or intellectual disability in human euploid blastocysts.

PubMed

He, Wenyin; Sun, Xiaofang; Liu, Lian; Li, Man; Jin, Hua; Wang, Wei-Hua

2014-01-01

Chromosomal anomalies in human embryos produced by in vitro fertilization are very common, which include numerical (aneuploidy) and structural (deletion, duplication or others) anomalies. Our previous study indicated that chromosomal deletion(s) is the most common structural anomaly accounting for approximately 8% of euploid blastocysts. It is still unknown if these deletions in human euploid blastocysts have clinical significance. In this study, we analyzed 15 previously diagnosed euploid blastocysts that had chromosomal deletion(s) using Agilent oligonucleotide DNA microarray platform and localized the gene location in each deletion. Then, we used OMIM gene map and phenotype database to investigate if these deletions are related with some important genes that cause genetic diseases, especially developmental delay or intellectual disability. As results, we found that the detectable chromosomal deletion size with Agilent microarray is above 2.38 Mb, while the deletions observed in human blastocysts are between 11.6 to 103 Mb. With OMIM gene map and phenotype database information, we found that deletions can result in loss of 81-464 genes. Out of these genes, 34-149 genes are related with known genetic problems. Furthermore, we found that 5 out of 15 samples lost genes in the deleted region, which were related to developmental delay and/or intellectual disability. In conclusion, our data indicates that all human euploid blastocysts with chromosomal deletion(s) are abnormal and transfer of these embryos may cause birth defects and/or developmental and intellectual disabilities. Therefore, the embryos with chromosomal deletion revealed by DNA microarray should not be transferred to the patients, or further gene map and/or phenotype seeking is necessary before making a final decision.

Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization

PubMed Central

Sabath, Daniel E.; Bender, Michael A.; Sankaran, Vijay G.; Vamos, Esther; Kentsis, Alex; Yi, Hye-Son; Greisman, Harvey A.

2017-01-01

Thalassemia is among the most common genetic diseases worldwide. α-Thalassemia is usually caused by deletion of one or more of the duplicated HBA genes on chromosome 16. In contrast, most β-thalassemia results from point mutations that decrease or eliminate expression of the HBB gene on chromosome 11. Deletions within the HBB locus result in thalassemia or hereditary persistence of fetal Hb. Although routine diagnostic testing cannot distinguish thalassemia deletions from point mutations, deletional hereditary persistence of fetal Hb is notable for having an elevated HbF level with a normal mean corpuscular volume. A small number of deletions accounts for most α-thalassemias; in contrast, there are no predominant HBB deletions causing β-thalassemia. To facilitate the identification and characterization of deletions of the HBA and HBB globin loci, we performed array-based comparative genomic hybridization using a custom oligonucleotide microarray. We accurately mapped the breakpoints of known and previously uncharacterized HBB deletions defining previously uncharacterized deletion breakpoints by PCR amplification and sequencing. The array also successfully identified the common HBA deletions --SEA and --FIL. In summary, comparative genomic hybridization can be used to characterize deletions of the HBA and HBB loci, allowing high-resolution characterization of novel deletions that are not readily detected by PCR-based methods. PMID:26612711

Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.

PubMed

Canver, Matthew C; Bauer, Daniel E; Dass, Abhishek; Yien, Yvette Y; Chung, Jacky; Masuda, Takeshi; Maeda, Takahiro; Paw, Barry H; Orkin, Stuart H

2014-08-01

The clustered regularly interspaced short [corrected] palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 nuclease system has provided a powerful tool for genome engineering. Double strand breaks may trigger nonhomologous end joining repair, leading to frameshift mutations, or homology-directed repair using an extrachromosomal template. Alternatively, genomic deletions may be produced by a pair of double strand breaks. The efficiency of CRISPR/Cas9-mediated genomic deletions has not been systematically explored. Here, we present a methodology for the production of deletions in mammalian cells, ranging from 1.3 kb to greater than 1 Mb. We observed a high frequency of intended genomic deletions. Nondeleted alleles are nonetheless often edited with inversions or small insertion/deletions produced at CRISPR recognition sites. Deleted alleles also typically include small insertion/deletions at predicted deletion junctions. We retrieved cells with biallelic deletion at a frequency exceeding that of probabilistic expectation. We demonstrate an inverse relationship between deletion frequency and deletion size. This work suggests that CRISPR/Cas9 is a robust system to produce a spectrum of genomic deletions to allow investigation of genes and genetic elements. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Epigenetic Control of Prolyl and Asparaginyl Hydroxylases in Prostate Cancer

DTIC Science & Technology

2009-07-01

2008). 4. Ikegami , T . et al. Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Biochem Biophys Res Commun 296...Wiley-VCH) 2009. – See appendix for full text. Abstracts: Case, A.J., Johns, A., Takahashi, T ., Waldschmidt, T ., and Domann, FE. (2008) Aberrant...thymic development in a T -lymphocyte specific SOD2 knock-out mouse. Free Radical Biology and Medicine 45: S133-S134. Awards: Case, A.J., Young

E. Graeme Robertson--dynamics in fluid and light.

PubMed

Kempster, P A; Gerraty, R P; Bower, S P C

2013-02-01

An eponymous lecture at the Australian and New Zealand Association of Neurologists Annual Scientific Meeting commemorates E. Graeme Robertson (1903-75), and some neurologists will know that particular Australian practices in clinical neurology, so far as they exist, have origins in his career. This is a historical article on the literary record of a man who had his own sense of history--an affinity with the past as well as an awareness of future generations of readers. He wrote authoritative texts on pneumoencephalography before new technology made it obsolete, and he produced a series of books on decorative architectural cast iron in Australian cities. A talent for visual interpretation seems to have drawn him to both of these topics; a common theme is contrast between light and dark, which is expatiated in images and in clear, well-written prose in his publications. We review his medical writings, including some largely forgotten principles of cerebrospinal fluid physics that he discovered when researching pneumoencephalography. We also explore his obsession with cast iron--its architectural historical significance, his techniques for photographing it, and some of the ways that it related to his life's work as a clinical neurologist. Copyright © 2012 Elsevier Ltd. All rights reserved.

Molecular and cytogenetic investigation of Y chromosome deletions over three generations facilitated by intracytoplasmic sperm injection.

PubMed

Minor, Agata; Wong, Edgar Chan; Harmer, Karynn; Ma, Sai

2007-08-01

The azoospermic factor (AZF) region is critical for normal spermatogenesis since microdeletions and partial deletions have been associated with infertility. We investigate the diagnostic ability of karyotyping in detecting clinically relevant Y chromosome deletions. The clinical significance of heterochromatin deletions, microdeletions and partial AZFc deletions is also evaluated. A patient with a Yq deletion, affected by severe oligoasthenoteratozoospermia, underwent intracytoplasmic sperm injection (ICSI) which resulted in the birth of a healthy baby boy. The patient, his father and his son underwent Y chromosome microdeletion and partial AZFc deletion screening. We also studied the aneuploidy rate in the sperm of the patient by fluorescent in situ hybridization. AZF microdeletions were absent in the family. However, microdeletion analysis confirmed that the Yq deletion was limited to the heterochromatin. We found a partial AZFc gr/gr deletion in all three family members. We observed an increased rate of sex chromosome aneuploidy in the infertile patient. Cytogenetic analysis was misleading in identifying the Yq breakpoint. Infertility observed in the patient was associated with the gr/gr partial deletion. However, because of the incomplete penetrance of gr/gr deletions, the consequence of the vertical transmission of the deletion through ICSI remains unknown. Copyright (c) 2007 John Wiley & Sons, Ltd.

Corrosion of Steel in a Black Mangrove Environment

DTIC Science & Technology

1982-10-01

neceaaary and Identify by block number) Black Mangrove Environment Chloride Salts Corrosion Iron- Tannin Complex Steel Tannic Acid Tropic Test Center...identified to be as follows: rain water falling through the mangrove canopy picks up salts and tannins from the black mangroves. The salts...attack steel, forming water-soluble ferric ions. The tannins react DD , JAN 73 •*/J EDITION OF » MOV 65 IS OBSOLETE UNCLASSIFIED SECURITY

USMC Acquisition Strategies For Cots Mobile Devices in the Tactical Environment

DTIC Science & Technology

2017-09-01

forms. Planned obsolescence is a designer and/or manufacturer approach that calls for product designs with artificially reduced life cycles (Seland...rapidly adopted by almost all cell phone manufacturers in short periods of time. Quick development of new products is deemed economical, and it is...Generally, a technology or product is considered obsolete when it is no longer being manufactured (Ward & Sohns, 2011). This decision to cease

National Dam Safety Program. Hunter Dam (MO 10029), Mississippi - Kaskaskia - St. Louis Basin, St. Louis County, Missouri. Phase I Inspection Report.

DTIC Science & Technology

1978-06-01

EDTION oF I NOV6S IS oBSOLETE EJUN I UNCLASSIFIED SECuRiITY CLASSIICATION OF THIS PAGE (Whon Datai Entered) SECURtITY CLASSIFICATION OF THIS PAO9(Whou...moveable. Since the watershed area is essentially one- third square mile with a time of concentration of flows substantially less than an hour, no

OCEANEXPO 󈨔 Bordeaux, France.

DTIC Science & Technology

1980-03-31

altogether necessary prior to actual recovery operations beginning, are expected to cost about $150M. 32 C-3-80 JE Figure 12 USSR 1. Ministry for Geology ...Latin Ame rica . Primnarily Ilteigsocse for the opulent Arabian DD I 31473>- EDITION Of’ I NOV 65 IS OBSOLETE UNCLASSIFIED $IN 102LF-14-601SECURITY...Sensing seafloor mining shipyards/shipbuilding USSR Minister of Geology 20. (con’t) --countries, conference discussions ranged from seabed mining

Pathogenesis and Management of Gonorrhea

DTIC Science & Technology

1987-01-01

100 mg PO bid or tetracycline 500 mg PO qid X 7 days.2Recommended for homosexual men and pharyngeal infections . remain the case is conjecture...CLASSIFICATION OF THIS PAGE All other editions are obsolete UNICASSIFIED From: UROGENTIAL INFECTIONS Edited by Amedeo Bondi, Donald D. Stieritz, Joseph M. Campos...apitbalial cell. ? Egestion FIGURE 1. THE PATHOGENESIS OF GONOCOCCAL INFECTION 118 MOLECULAR BIOLOGY Much has been learned in recent years about the

Tunable Optical Sources.

DTIC Science & Technology

1980-11-01

finite aperture size 5. A. E. Siegman , "Unstable optical resonators for laser of the YAG rod, applications," Proc. IEEE 53, 217-287 (1965); "Unstable...Pumped LiNbO3 Tunable Source Radial Birefringent Element Computer Controlled Laser Attenuator Slab Configuration Laser Source 20. ABSTRACT (Continue on...have invented and demonstrated a computer controlled laser attenu- ator. .... Cont inued DD Il 7 1473 EDITION OF I NOV 01 IS OBSOLETE UNCLASSIFIEDAN

XM1 Gunnery Training and Aptitude Requirements Analyses

DTIC Science & Technology

1981-02-01

of the XML tank weapons system. Army materiel systems such as the XK tank are initiated, developed, de - ployed, supported, modified and disposed in...Analysis ( TASA ) to satisfy the FEA requirement. Users of the TASA at the Armor School were uniformly critical of the work. Generally described as...inaccurate, incomplete and to a large extent, obsolete the TASA failed to provide the information necessary for addressing the concerns of future operators

Have Basic Mathematical Skills Grown Obsolete in the Computer Age: Assessing Basic Mathematical Skills and Forecasting Performance in a Business Statistics Course

ERIC Educational Resources Information Center

Noser, Thomas C.; Tanner, John R.; Shah, Situl

2008-01-01

The purpose of this study was to measure the comprehension of basic mathematical skills of students enrolled in statistics classes at a large regional university, and to determine if the scores earned on a basic math skills test are useful in forecasting student performance in these statistics classes, and to determine if students' basic math…

An Analysis of Challenges Faced by Students Learning in Virtual and Open Distance Learning System: A Case of Bindura University of Science Education (BUSE)

ERIC Educational Resources Information Center

Dodo, Obediah; Makwerere, David; Parwada, Matavire; Parwada, Cosmas

2013-01-01

After realizing that the traditional modes of tuition in Zimbabwe's andragogy had either gone obsolete or over-crowded, BUSE ventured into a "virtualised" model of open and distance learning as a way of out-doing other competing universities. However, as the programme was rolled out, there came a myriad of challenges affecting the…

The Foreign Disclosure and Technical Information System (FORDTIS) User Manual

DTIC Science & Technology

1985-07-01

INDIA 10 BRITISH INDIAN OCEAN TERRITORY IP CLIPPERTON ISLAND IQ UNITED STATES MISCELLANEOUS PACIFIC ISLANDS (obsolete) IR , IRAN IS ISRAEL IT...CARTIER ISLANDS AU AUSTRIA AV ANGUILLA AY ANTARCTICA BA BAHRAIN BB BARBADOS ’ - ’ BC BOTSWANA BD BERMUDA BE BELGIUM BP...BAHAMAS, THE BG BANGLADESH BH BELIZE BL BOLIVIA BM BURMA BN BENIN (formerly DM) BP SOLOMON ISLANDS BQ NAVASSA ISLAND BR BRAZIL BS BASSAS DA INDIA

Applying a Qualitative Modeling Shell to Process Diagnosis: The Caster System.

DTIC Science & Technology

1986-03-01

Process Diagnosis: The Caster System by Timothy F. Thompson and William J. Clancey Department of Computer Science Stanford University Stanford, CA 94303...MODELING SHELL TO PROCESS DIAGNOSIS: THE CASTER SYSTEM 12 PERSONAL AUTHOR(S) TIMOTHY F. THOMPSON. WESTINGHOUSE R&D CENTER, WILLIAM CLANCEY, STANFORD...editions are obsolete. Applying a Qualitative Modeling Shell to Process Diagnosis: The Caster System by Timothy F. Thompson, Westinghouse R&D Center

Aircraft Mishap Fire Pattern Investigations

DTIC Science & Technology

1985-08-01

AD-AI61 094 AIRC1Arr WSWEA FlREg PATMEN INVESTIGATIONS . Joseph M. Kuchta Mining and industrial Cadre15143 Green latetrutiovalp 𔃻nco 54 Sewickley...ORGANIZATION REPORT NUMSER(S) AFWAL-TR-85-2057 6. NAME OF PERFORMING ORGANIZATION kb. OFFICE SYMBOL 7a. NAME OF MONITORING ORGANIZATION Mining and Industrial...IS OBSOLETE. Unc .assi fied SECURITY CLASSIFICATION OF THIS PAGE ( / FOREWARD This report was prepared by the Mining and Industrial Cadre of Green

Keeping Up With the Drones: Is Just War Theory Obsolete

DTIC Science & Technology

2010-04-29

the laws of armed conflict. For centuries, just war principles have defined how responsible states have agreed to ethically wage war. The manner in...conflict. For centuries, just war principles have defined how responsible states have agreed to ethically wage war. The manner in which unmanned...3 will be morally and ethically waged. Failure to address the gaps this new technology exposes in traditional teachings will have profound

On Preparing for Squadron Command

DTIC Science & Technology

1988-04-01

Gortler, Majur Gordon D. "Management Development---Could the Air Force Be Doing More?" Resear,;h Study, Air Command and Staff College. 1 07:3. 20...ABSTRACT (Continue on reverse If necessary and identify by block number) -This study addresses the broad issue of preparing Air Force officers for...are obsolete. SECURITY CLASSIFICATION OF THIS PAGE UNCLASSIFIED - - PREFACE This study addresses the broad Issue of preparing Air Force officers to

Security Cooperation and Professional Military Education: Developing Better Theater Campaign Planners

DTIC Science & Technology

2012-05-22

publication of the Security Cooperation Guidance ( SCG ), 32 U.S. Joint Chiefs of Staff, Joint Operation...format and content of the plans themselves. 2 The 2003 release of the classified SCG , which replaced TEPs with TSCPs, rendered CJCSM 3113.01 obsolete...interests while providing the SecDef increased visibility on and control over security cooperation activities, but the SCG was not as explicit in its

Simplification and Standardization of Dot-ELISA for Human Schistosomiasis Mansoni

DTIC Science & Technology

1987-01-01

Cross-reactivity between the S. mansoni antigen and human fascioliasis sera was noticed in 2 out of 8 patient sera. Good correlation between the...small tients with fascioliasis were tested, 2 gave weakly positive reactions with SWAP, but none cross- reacted with SEA. TABLE I. Comparison between...other editions a;. obsolete ... .,.. UNCLASSIFIED UNCLASSIEDE 17/88 (Contd.) 19. fascioliasis sera was noticed in 2 out of 8 patient sera. Good

DNA EMP Awareness Course Notes. Supplement to Third Edition.

DTIC Science & Technology

1978-07-31

UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (When Data Entered) REPORT DOCUMENTATION PAGE READ INSTRUCTIONS BEFORE COMPLETING FORM I REPORT...the environment through system design and testing. FORM 143 E,,N F’NOV 65 IS OBSOLETE DD JAN73 1473 EDITION OF UNCLASSIFIED SECURITY CLASSIFICATION OF...fields generated tems mission and deployment factors by the prompt gammas. Other forms of EMP, where these environments should be con- such as

Defining ’Anonymity’ in Networked Communication, Version 1

DTIC Science & Technology

2011-12-01

conference that features many current works on anonymity [5]. 7. References [1] D . Chaum , “Security without Identification: Transaction Systems...to make Big Brother Obsolete,” Communications of the ACM 28:10 (1985), pp. 1030-1044. [2] D . Chaum , “The Dining Cryptographers Problem: Unconditional...Sender and Recipient Untraceability,” Journal of Cryptology 1:1 (1988), pp. 65-75. [3] D . Chaum , “Untraceable Electronic Mail, Return Addresses

Adaptive Control System of Hydraulic Pressure Based on The Mathematical Modeling

NASA Astrophysics Data System (ADS)

Pilipenko, A. V.; Pilipenko, A. P.; Kanatnikov, N. V.

2016-04-01

In this paper, the authors highlight the problem of replacing an old heavy industrial equipment, and offer the replacement of obsolete control systems on the modern adaptive control system, which takes into account changes in the hydraulic system of the press and compensates them with a corrective action. The proposed system can reduce a water hammer and thereby increase the durability of the hydraulic system and tools.

Psychological Analyses of Courageous Performance in Military Personnel

DTIC Science & Technology

1990-08-01

British Columbia ARI Scientific Coordination Office, London Milton Katz, Chief Office of Basic Research Michael Kaplan , Director OTIC August1990 ELECTE...For NTIS Ri University of British Columbia DTic TAB Just fitIcat lo Technical review by Dy __Dttibut ton/ Michael Kaplan Avallability CodesDIst...22c. OFFICE SYMBOL Michael Kaplan (202) 274-8722 PERT-BR DD Form 1473, JUN 86 Previous editions are obsolete. SECURITY CLASSIFICATION OF THIS PAGE

MO-G-BRD-01: Point/Counterpoint Debate: Arc Based Techniques Will Make Conventional IMRT Obsolete

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shepard, D; Popple, R; Balter, P

2014-06-15

A variety of intensity modulated radiation therapy (IMRT) delivery techniques have been developed that have provided clinicians with the ability to deliver highly conformal dose distributions. The delivery techniques include compensators, step-and-shoot IMRT, sliding window IMRT, volumetric modulated arc therapy (VMAT), and tomotherapy. A key development in the field of IMRT was the introduction of new planning algorithms and delivery control systems in 2007 that made it possible to coordinate the gantry rotation speed, dose rate, and multileaf collimator leaf positions during the delivery of arc therapy. With these developments, VMAT became a routine clinical tool. The use of VMATmore » has continued to grow in recent years and some would argue that this will soon make conventional IMRT obsolete, and this is the premise of this debate. To introduce the debate, David Shepard, Ph.D. will provide an overview of IMRT delivery techniques including historical context and how they are being used today. The debate will follow with Richard Popple, Ph.D. arguing FOR the Proposition and Peter Balter, Ph.D. arguing AGAINST it. Learning Objectives: Understand the different delivery techniques for IMRT. Understand the potential benefits of conventional IMRT. Understand the potential benefits of arc-based IMRT delivery.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merriwether, D.A.; Huston, S.L.; Bunker, C.A.

An intergenic region V Mitochondrial DNA (mtDNA) 9 bp deletion located between the genes for tRNA{sup LYS} and cytochrome oxidase II was discovered in a small percentage of Nigerian and Ivory Coast natives. Previously this deletion has been described as Asian-specific and has been reported throughout the New World, Asia, S.E. Asia, and the Pacific Islands at frequencies ranging from 0% to 100%. In the New World and the Pacific Islands, the deletion is almost always accompanied by an Hae III restriction site gain at nt 16517. All 9 occurrences of the deletion observed in Africa (from four different populations)more » co-occur with the Hae III 16517 site gain, indicating that the African deletion probably shares a common origin with the deletion described as {open_quotes}Asian-specific{close_quotes}. The deletion was found in Benin and Sokoto, Nigeria in 2/54 Edo Bini, 1/2 Edo Ishan, 3/99 Hausa, 0/18 Fulani, and 0/16 other Nigerians. The deletion was also detected in 3/115 Ivory Coast natives from Abidjan. A 9 bp insertion (triplication) was observed in 1/115 Ivory Coast natives. The triplicated individual also possessed the Hae III 16517 site gain. The fragment containing the African deletion was sequenced and found to be identical in sequence to the Asian deletion region. D-loop sequence of nts 15975 to 00048 revealed that 2 of the 3 Ivory Coast deleted individuals and 1 of the 6 Nigerians deleted (Hausa) had a T-C transition at nt position 16189 which is common in New World-deleted individuals. These results raise the possibility that the occurrence of this deletion predates the separation of Asian and African populations from a common ancestral populations, or that the deletion has occurred more than once in human evolution. Either explanation requires that caution be exercised when using the 9 bp deletion as a population marker.« less

In search of methods enhancing fluency in reading: An examination of the relations between time constraints and processes of reading in readers of German.

PubMed

Bar-Kochva, Irit; Hasselhorn, Marcus

2015-12-01

The attainment of fluency in reading is a major difficulty for reading-disabled people. Manipulations applied on the presentation of texts, leading to "on-line" effects on reading (i.e., while texts are manipulated), are one direction of examinations in search of methods affecting reading. The imposing of time constraints, by deleting one letter after the other from texts presented on a computer screen, has been established as such a method. In an attempt to further understand its nature, we tested the relations between time constraints and processes of reading: phonological decoding of small orthogrpahic units and the addressing of orthographic representations from the mental lexicon. We also examined whether the type of orthogrpahic unit deleted (lexical, sublexical, or nonlexical unit) has any additional effect. Participants were German fifth graders with (n = 29) or without (n = 34) reading disability. Time constraints enhanced fluency in reading in both groups, and to a similar extent, across conditions. Comprehension was unimpaired. These results place the very principle of time constraints, regardless of the orthographic unit manipulated, as a critical factor affecting fluency in reading. However, phonological decoding explained a significant amount of variance in fluency in reading across all conditions in reading-disabled children, whereas the addressing of orthographic representations was the consistent predictor of fluency in reading in regular readers. These results indicate a qualitative difference in the processes explaining the variance in fluency in reading in regular and reading-disabled readers and suggest that time constraints might not have an effect on the relations between these processes and reading performance. Copyright © 2015 Elsevier Inc. All rights reserved.

Submicroscopic deletions at 22q11.2: Variability of the clinical picture and delineation of a commonly deleted region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lindsay, E.A.; Shaffer, L.G.; Greenberg, F.

DiGeorge anomaly (DGA) and velo-cardio-facial syndrome (VCFS) are frequently associated with monosomy of chromosome region 22q11. Most patients have a submicroscopic deletion, recently estimated to be at least 1-2 Mb. It is not clear whether individuals who present with only some of the features of these conditions have the deletion, and if so, whether the size of the deletion varies from those with more classic phenotypes. We have used fluorescence in situ hybridization (FISH) to assess the deletion status of 85 individuals referred to us for molecular analysis, with a wide range of DGA-like or VCFS-like clinical features. The testmore » probe used was the cosmid sc11.1, which detects two loci about 2 Mb apart in 22q11.2. Twenty-four patients carried the deletion. Of the deleted patients, most had classic DGA or VCFS phenotypes, but 6 deleted patients had mild phenotypes, including 2 with minor facial anomalies and velopharyngeal incompetence as the only presenting signs. Despite the great phenotypic variability among the deleted patients, none had a deletion smaller than the 2-Mb region defined by sc11.1. Smaller deletions were not detected in patients with particularly suggestive phenotypes who were not deleted for sc11.1, even when tested with two other probes from the DGA/VCFS region. 24 refs., 2 figs., 2 tabs.« less

Neuronal activity in the isolated mouse spinal cord during spontaneous deletions in fictive locomotion: insights into locomotor central pattern generator organization

PubMed Central

Zhong, Guisheng; Shevtsova, Natalia A; Rybak, Ilya A; Harris-Warrick, Ronald M

2012-01-01

We explored the organization of the spinal central pattern generator (CPG) for locomotion by analysing the activity of spinal interneurons and motoneurons during spontaneous deletions occurring during fictive locomotion in the isolated neonatal mouse spinal cord, following earlier work on locomotor deletions in the cat. In the isolated mouse spinal cord, most spontaneous deletions were non-resetting, with rhythmic activity resuming after an integer number of cycles. Flexor and extensor deletions showed marked asymmetry: flexor deletions were accompanied by sustained ipsilateral extensor activity, whereas rhythmic flexor bursting was not perturbed during extensor deletions. Rhythmic activity on one side of the cord was not perturbed during non-resetting spontaneous deletions on the other side, and these deletions could occur with no input from the other side of the cord. These results suggest that the locomotor CPG has a two-level organization with rhythm-generating (RG) and pattern-forming (PF) networks, in which only the flexor RG network is intrinsically rhythmic. To further explore the neuronal organization of the CPG, we monitored activity of motoneurons and selected identified interneurons during spontaneous non-resetting deletions. Motoneurons lost rhythmic synaptic drive during ipsilateral deletions. Flexor-related commissural interneurons continued to fire rhythmically during non-resetting ipsilateral flexor deletions. Deletion analysis revealed two classes of rhythmic V2a interneurons. Type I V2a interneurons retained rhythmic synaptic drive and firing during ipsilateral motor deletions, while type II V2a interneurons lost rhythmic synaptic input and fell silent during deletions. This suggests that the type I neurons are components of the RG, whereas the type II neurons are components of the PF network. We propose a computational model of the spinal locomotor CPG that reproduces our experimental results. The results may provide novel insights into the organization of spinal locomotor networks. PMID:22869012

5p14 deletion associated with microcephaly and seizures

PubMed Central

Johnson, E.; Marinescu, R; Punnett, H.; Tenenholz, B.; Overhauser, J.

2000-01-01

We report on a father and son who have an interstitial deletion of 5p14. The father is clinically and mentally normal while the son has significant clinical involvement including microcephaly, seizures, and global developmental delay. The extent of the 5p14 deletion was determined using fluorescence in situ hybridisation (FISH). The deletion in this present family is smaller than a deletion previously described in a multigenerational family that lacks any clinical phenotype. This report shows that a 5p14 deletion does not always lead to a normal phenotype.


Keywords: interstitial deletion; chromosome 5; fluorescence in situ hybridisation; cri du chat syndrome PMID:10662813

A Deletion of More than 800 kb Is the Most Recurrent Mutation in Chilean Patients with SHOX Gene Defects.

PubMed

Poggi, Helena; Vera, Alejandra; Avalos, Carolina; Lagos, Marcela; Mellado, Cecilia; Aracena, Mariana; Aravena, Teresa; Garcia, Hernan; Godoy, Claudia; Cattani, Andreina; Reyes, Loreto; Lacourt, Patricia; Rumie, Hana; Mericq, Veronica; Arriaza, Marta; Martinez-Aguayo, Alejandro

2015-01-01

Deletions in the SHOX gene are the most frequent genetic cause of Leri-Weill syndrome and Langer mesomelic dysplasia, which are also present in idiopathic short stature. To describe the molecular and clinical findings observed in 23 of 45 non-consanguineous Chilean patients with different phenotypes related to SHOX deficiency. Multiplex ligation-dependent probe amplification was used to detect the deletions; the SHOX coding region and deletion-flanking areas were sequenced to identify point mutations and single-nucleotide polymorphisms (SNPs). The main genetic defects identified in 21 patients consisted of deletions; one of them, a large deletion of >800 kb, was found in 8 patients. Also, a smaller deletion of >350 kb was observed in 4 patients. Although we could not precisely determine the deletion breakpoint, we were able to identify a common haplotype in 7 of the 8 patients with the larger deletion based on 22 informative SNPs. These results suggest that the large deletion-bearing allele has a common ancestor and was either introduced by European immigrants or had originated in our Amerindian population. This study allowed us to identify one recurrent deletion in Chilean patients; also, it contributed to expanding our knowledge about the genetic background of our population. © 2015 S. Karger AG, Basel.

Velo-cardio-facial syndrome: Frequency and textent of 22q11 deletions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lindsay, E.A.; Goldberg, R.; Jurecic, V.

Velo-cardio-facial (VCFS) or Shprintzen syndrome is associated with deletions in a region of chromosome 22q11.2 also deleted in DiGeorge anomaly and some forms of congenital heart disease. Due to the variability of phenotype, the evaluation of the incidence of deletions has been hampered by uncertainty of diagnosis. In this study, 54 patients were diagnosed with VCFS by a single group of clinicians using homogeneous clinical criteria independent of the deletion status. Cell lines of these patients were established and the deletion status evaluated for three loci within the commonly deleted region at 22q11.2 using fluorescence in situ hybridization (FISH). Inmore » 81% of the patients all three loci were hemizygous. In one patient we observed a smaller interstitial deletion than that defined by the three loci. The phenotype of this patient was not different from that observed in patients with larger deletions. 22 refs., 2 figs., 1 tab.« less

Effective Use of Females to Support Nation Building Operations in Afghanistan

DTIC Science & Technology

2009-04-01

Building. Santa Monica, CA: RAND Corporation, 2008. Donini , Antonio, et al,eds. Nation-Building Unraveled? Aid, Peace and Justice in Afghanistan...Conflict, and Peacekeeping, ed. Mazurana et al. Lanham, MD: Rowman and Littlefield Publishers, 2005. Frels, M . “Women Warriors: Oxymoron or Reality...MD: Rowman and Littlefield Publishers, 2005. McSally, M . “Women in Combat: Is the Current Policy Obsolete?” Master’s Thesis, Maxwell AFB, AL: Air

Navy Force Structure and Shipbuilding Plans: Background and Issues for Congress

DTIC Science & Technology

2013-11-08

deferred repairs rise exponentially. The end result will be ships being decommissioned before their expected service life ( ESL ) due to degraded material...conduct routine operations, culminating in decommissioning ships before their ESL . Even when the trend is reversed and more funding is made available for...repair broken equipment and upgrade obsolete systems needed for deployment, and to ensure each ship reaches its ESL of thirty-five to forty years.23

Optical Instrumentation Support for the Airborne Ionospheric Observatory

DTIC Science & Technology

1988-07-01

mailing list, or if the addressee is no longer employed by your organization, please notify AFGL/DAA, Hanscom AFB, MA 01731. This will assist us in...1 22b TELEPHONE (Include Area Code) 22c. OFFICE SYMBOL , Edward J. Weber , 617 377 31211 LIS OD Form 1473, JUN 86 Pr.,c us erjdicrii.re obsolete...1. Contract Objectives: To participate in ionospheric research programs using the new optical equipment (designed and constructed by Keo Consultants

U.S. Naval Observatory Annual Report 2001-2002

DTIC Science & Technology

2002-06-01

practical astronomical information and data via printed publications, software products, and the World Wide Web. The Department’s products are used by the...Astronomical Almanac. Each almanac edition contains data for 1 year. These pub- lications are now on a well-established production schedule. The Astronomical...complementary Web site. In place of this list, the printed book will list the constants ~and references! used in the computations. Data for the obsolete Besselian

Ramstein AB (Germany, F.R.) Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1985-05-01

All other editions ere obsolete. 22b TELEPHONE 0nc/ude Are« Code ) (610) 256-2625 22( OFFICE SYMBOL USAFETAC/LDD SECURITY CLASSIFICATION OF ’HIS...lii isaia bt&l TOTAL NUMIE« 3F 0«S»VATIONS 913_ ■V <?’’■... J f. H r : T » : PERCENTAGf fR.QUENCY OF WIND 0’R!:CV(ON! AND SPEED (FROM HOURLY

Human Capital Analytics to Manage the Army Officer Population

DTIC Science & Technology

2017-06-09

employees from spending time and energy on a career path projected to be obsolete. Instead, managers are able to use data to show employees where they...HUMAN CAPITAL ANALYTICS TO MANAGE THE ARMY OFFICER POPULATION A thesis presented to the Faculty of the U.S. Army Command and...From - To) AUG 2016 – JUNE 2017 4. TITLE AND SUBTITLE Human Capital Analytics to Manage the Army Officer Population 5a. CONTRACT NUMBER 5b

Surface Modification of Orthodontic Bracket Models via Ion Implantation: Effect on Coefficients of Friction

DTIC Science & Technology

1989-01-01

FEB 2 2 1990 Stephen Walter Andrews, D.M.D. The University of North Carolina at Chapel Hill Department of Orthodontics School of Dentistry 1989 Robert...PROJECT TASK WORK UNIT ELEMENT NO. NO. NO. ACCESSION NO. 11. TITLE (Include Security Classification) (UNCLASSIFIED) SURFACE MODIFICATION OF ORTHODONTIC ...Previous editions are obsolete. SECURITY CLASSIFICATION OF THIS PAGE AFIT/CI "OVERPRINT" SURFACE MODIFICATION OF ORTHODONTIC BRACKET MODELS VIA ION

Evaluation of a Ferroelectric Liquid Crystal Spatial Light Modulator

DTIC Science & Technology

1991-01-09

MAR 83 APR edition may be used until exhausted SECURITY CLASSIFICATION OF THIS PAGE All other edition% are obsolete UbIu.LAb F L l.D i/(ii Blank...7 VII. CONCLUSIONS.................................................. 8 Accesion For- NTIS CRA&I ~ 4Ii U, ai-;-oui iced L DiA: ibutiko: i...thin phase grating. The authors are also thankful for the assistance of Ms. Cindy Gabardi in preparing this manuscript. v/(vi Blank) 1. INTRODUCTION A

Portable Automated Test Station: Using Engineering-Design Partnerships to Replace Obsolete Test Systems

DTIC Science & Technology

2015-04-01

troubleshooting avionics system faults while the aircraft is on the ground. The core component of the PATS-30, the ruggedized laptop, is no longer sustainable...as well as trouble shooting avionics system faults while the aircraft is on the ground. The PATS-70 utilizes up-to-date, sustainable technology for...Operational Flight Program (OFP) software loading and diagnostic avionics system testing and includes additional TPSs to enhance its capability

Ultrastructure Processing and Environmental Stability of Advanced Structural and Electronic Materials

DTIC Science & Technology

1992-08-31

NC r") Form 1473, JUN 86 Previous editions are obsolete SECURITY CLASSIFICATION OF THIS PACE I 18. Subject Terms (Continued) I analysis, aging , band...detail the several steps involved in the processing of sol-gel derived optical silicas: I 1) mixing, 2) casting, 3) gelation, 4) aging , 5) drying, 6...ultrastructurcs, such as for doping applications and laser-enhanced densification. The possible disadvantages discussed in this Chapter are inherent

A Combinatorial Geometry Computer Description of the MEP-021A Generator Set

DTIC Science & Technology

1979-02-01

Generator Computer Description Gasoline Generator GIFT MEP-021A 20. ABSTRACT fCbntteu* an rararaa eta* ft namamwaay anal Identify by block number) This... GIFT code is also stored on magnetic tape for future vulnerability analysis. 00,] 󈧚*7,1473 EDITION OF • NOV 65 IS OBSOLETE UNCLASSIFIED SECURITY...the Geometric Information for Targets ( GIFT ) computer code. The GIFT code traces shotlines through a COM-GEOM description from any specified attack

Ion-Selective Electrodes for Basic Drugs.

DTIC Science & Technology

1981-01-01

coated wire ion selective electrodes for methadone , methylamphetamine, J cocaine, protriptyline i 20. ABSTRACT (Continue on reverse side If neeeeary...end Identify by block number) Coated-wire ion-selective electrodes based on dinonylnaphthalene u-i sulfonic acid (DNNS) are prepared for methadone ...range from 10- 5.5M for cocaine and methylamphetamine electrodes to 10Ś.0M for methadone , and 10-6.5M for DD I 󈨍 1473 EDITION OF I NOV 5 IS OBSOLETE

Visual Perception of Elevation

DTIC Science & Technology

1992-01-20

by bloe num r ) FIELD oOUP suB.O. ’Spatial localization, Pitch, Roll, Eve level, Visual Localizatiyn1 VPR, VPV, Perception,Focentri(i spatia ca...TIlEIPHONE NUMBER 22c. OFFICE SYMIO. Dr. John Tangney (202) 767-5021 AFOSR/N DO FORM 1473, 83 APR EDITION OF I JAN 73 I OBSOLETE. 19 SECURITY... Schermerhorn Hall New York, NY 10027 20 January 1992 Interim Report for Period 1 January 1991 - 31 December 1991 Unclassified Prepared for :i

IT Acquisition: Expediting the Process to Deliver Business Capabilities to the DoD Enterprise. Revised Edition

DTIC Science & Technology

2012-07-01

effectively manage delivery of information capabilities. Under IT 360, they will need to incorporate constantly evolving, market -driven commercial systems...traditional acquisition system; under IT 360, these processes are largely obsolete and create oversight ambiguities. • Congress requires that funds be...2004). Furthermore, because the product is not available on the commercial market , the development of any complementary updates will also need to be

Synthesis and Characterization of High Energy Polymers.

DTIC Science & Technology

1981-03-31

have been poly(cis-l ,4-butadiene), CTBN , and HTPB I=1s of nitrated and DD I JA 7 1473 EDITION OF I NOV 45 1& OBSOLETE SE1CURITY CLAIISIFI1 TIN Of...cis- butadiene), PB, carboxy-tenninated poly(butadiene-co-acrylonitrile), CTBN and hydroxy-terminated poly(butadiene), HTPB. For the nitration of...evaluation. Progress Report I. Nitration of Diene Polymers and Cgolymers A. Nitromercuration of Carboxy-terminated Butadiene Acrylonitrile Copolymer ( CTBN

Water and health.

PubMed

Guidotti, T L; Conway, J B

1984-10-01

The systems protecting the quality of drinking water in the United States are deteriorating. Many urban water and sewer systems are obsolete. Industrial wastes are imposing a burden on wastewater treatment facilities. In the U.S., outbreaks of water-borne disease are primarily limited to enteritis associated with viruses or Giardia. Issues in the contamination of drinking water by toxic substances include disposal practices, accidental contamination, agricultural runoff and chlorination byproducts. Physicians must support stringent enforcement of water quality standards.

Coding Gains for Rank Decoding

DTIC Science & Technology

1990-02-01

PM PUB=C RERZASB DISThIDUnO UNLI M . U.S. ARMY LABORATORY COWMAND BALLISTIC RESEARCH LABORATORY ABERDEEN PROVING GROUND, MARYLAND 9o 03 is.032...Proving Ground, MD 21005-5066 ATITN: SLCBR-D Aberdeen Proving Ground, M 21005-5066 8a NAME OF FUNDING , SPONSORING 8b OFFICE SYMBOL 9 PROCUREMENT...Previouseditionsare obsolete. SECURITY CLASSIFILATION OF THIS PAGE mm m ini IIIIIIIIIIIIIII I Isn FI E Contents 1 Soft Decision Concepts 1 2 Coding Gain 2 3

How Space - The Fourth Operational Medium - Supports Operational Maneuver.

DTIC Science & Technology

1987-05-17

51981 87-3044 87 9 18 014 UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE Form Approved REPORT DOCUMENTATION PAGE OMB No. 0704-0188 la. REPORT...P. J anecek (14213 AT L_ aCd) ZL-wI DO Form 1473, JUN 86 Previous editions are obsolete. SECURITY CLASSIFICATION OF THIS PAGE UNCLASSIFIED . ~18...Space technology, superior and enhanced weapons, and space systems combine to form spacepower that can be exploited to enhance ground force mission

Bill Gates, If You're so Rich, How Come You're Not Smart? Point of View Essay

ERIC Educational Resources Information Center

Bracey, Gerald

2005-01-01

Bill Gates and the governors were quite vague about what makes the schools obsolete or what to do about it. What is it, exactly, that schools are not teaching that they need to? Bill Gates also claimed that American kids were at the top in fourth grade, but at the bottom by 12th. The author congratulates Gates for focusing some attention on…

An Infrastructure for Multi-Level Secure Service-Oriented Architecture (MLS-SOA) Using the Multiple Single-Level Approach

DTIC Science & Technology

2009-12-17

IEEE TDKE, 1996. 8( 1). 14. Garvey, T.D., The inference Problem for Computer Security. 1992, SRI International. 15. Chaum , D ., Blind Signatures for...Pervasive Computing Environments. IEEE Transactions on Vehicular Technology, 2006. 55(4). 17. Chaum , D ., Security without Identification: Transaction...Systems to make Big Brother Obsolete. Communications of the ACM 1985. 28(10). 18. Chaum , D ., Untraceable Electronic Mail, Return Addresses, and Digital

Projectile Measurements and Instrumentation Laboratory Mass Property Measurements

DTIC Science & Technology

1974-09-01

STATEMENT (ol III* abalrael anlarad In Block 20, II dlllaranl Irom Rmpotl) 11. SUPPLEMENTARY NOTES Available in DDC . 1». KEY WORDS fConllnu* on...FORM I JAN 73 1473 EDITION OF I NOV SB IS OBSOLETE UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (Whmn Dmlm Enlmrmd) ■auHHaUi^L^u^. ^^-..-^-i... CLASSIFICATION Of THIS PAQE(Whm> Dmlm Knltrmd) Item 19 (Continued): Top Loading Balance Center of Gravity Balance Moment of Inertia Instrument

Hardened Reentry Vehicle Development Program. Erosion-Resistant Nosetip Technology

DTIC Science & Technology

1978-01-01

Best Available Copy .- / L A- UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (When Data Enttered) _____________________ REPORT DOCUMENTATION PAGE...OF PAGES t Washington, D. C. 20305 3" TK~ 14 MONITORING AGENCY NAME a ADDRESfrif different troin Controllmng~ Office) IS. SECURITY CLA5--M~e7ry...tests indicate( 1 low probability of survival for DD IJAN 73 1473 EDITION OF I NOV 65 IS OBSOLETE UCASFE 41 -n0 SECURITY CLASSIFICATION OF THIS PAGE

Proceedings of the ’Managing the Industrial Modernization Process’ Conference

DTIC Science & Technology

1990-05-05

international companies --- with international interests taking top priority. The consequences of these companies ’ decisions --- about plant location, hiring, R...Some key plants going off shore. Companies like ours exiting the defense market; others putting their defense divisions up for sale and, at least, one... designed , very quickly become obsolete and unable to be modified. An example was given of a company that developed a large, multi-million dollar data

Proceedings of the Conference on the Design of Experiments in Army Research, Development and Testing (29th)

DTIC Science & Technology

1984-06-01

SEQUENTIAL TESTING (Bldg. A, Room C) 1300-1330 ’ 1330-1415 1415-1445 1445-1515 BREAK 1515-1545 A TRUNCATED SEQUENTIAL PROBABILITY RATIO TEST J...suicide optical data operational testing reliability random numbers bootstrap methods missing data sequential testing fire support complex computer model carcinogenesis studies EUITION Of 1 NOV 68 I% OBSOLETE a ...contributed papers can be ascertained from the titles of the

The emergence of international terrorism and technological changes: have these changes made the Law of Armed Conflict obsolete?

PubMed

Kaar, Jason F

2007-12-01

The Geneva Conventions of 1949, the primary basis of the present Law of Armed Conflict, are primarily a reaction to past wars, including World War II. Since 1949, armed conflict had evolved from large armies controlled by nations to fighting by nations, groups, and organization, and are fought both nationally and internationally. This article explores some of the difficulties as a result of these changes.

PAR1 deletions downstream of SHOX are the most frequent defect in a Spanish cohort of Léri-Weill dyschondrosteosis (LWD) probands.

PubMed

Benito-Sanz, Sara; del Blanco, Darya Gorbenko; Aza-Carmona, Miriam; Magano, Luis F; Lapunzina, Pablo; Argente, Jesús; Campos-Barros, Angel; Heath, Karen E

2006-10-01

Léri-Weill dyschondrosteosis (LWD) is a skeletal dysplasia characterized by disproportionate short stature and Madelung deformity. Mutations or deletions of the SHOX gene have been previously identified as the main cause of LWD. We recently identified the existence of a second class of pseudoautosomal region 1 (PAR1) deletions which do not include SHOX, implicated in the etiopathogenesis of LWD. The deletions map at least 30-250 kb downstream of SHOX, are variable in size and clearly cosegregate with the LWD phenotype. In order to determine the frequency of this new type of deletions in the Spanish population we analyzed the distribution of PAR1 defects, including the screening of SHOX deletions, mutations, and PAR1 deletions downstream of SHOX, in a total of 26 LWD probands by a combination of MLPA, microsatellite analysis, SNP genotyping, dHPLC, and DNA sequencing. A molecular defect was identified in 16/26 LWD patients (61.5%): 10 PAR1 deletions downstream of SHOX, four SHOX encompassing deletions, and two SHOX mutations. No apparent phenotypic differences were observed between patients with SHOX defects and those with PAR1 deletions downstream of SHOX. In the examined cohort of Spanish LWD probands, PAR1 deletions downstream of SHOX represent the highest proportion of identified mutations (38%) compared to SHOX deletions (15%) and mutations (8%). As a consequence of our findings, the screening of this region should be included in the routine genetic testing of LWD. Also, LWD patients who tested negative for SHOX defects should be re-evaluated for PAR1 deletions downstream of SHOX.

Detection limit of intragenic deletions with targeted array comparative genomic hybridization

PubMed Central

2013-01-01

Background Pathogenic mutations range from single nucleotide changes to deletions or duplications that encompass a single exon to several genes. The use of gene-centric high-density array comparative genomic hybridization (aCGH) has revolutionized the detection of intragenic copy number variations. We implemented an exon-centric design of high-resolution aCGH to detect single- and multi-exon deletions and duplications in a large set of genes using the OGT 60 K and 180 K arrays. Here we describe the molecular characterization and breakpoint mapping of deletions at the smaller end of the detectable range in several genes using aCGH. Results The method initially implemented to detect single to multiple exon deletions, was able to detect deletions much smaller than anticipated. The selected deletions we describe vary in size, ranging from over 2 kb to as small as 12 base pairs. The smallest of these deletions are only detectable after careful manual review during data analysis. Suspected deletions smaller than the detection size for which the method was optimized, were rigorously followed up and confirmed with PCR-based investigations to uncover the true detection size limit of intragenic deletions with this technology. False-positive deletion calls often demonstrated single nucleotide changes or an insertion causing lower hybridization of probes demonstrating the sensitivity of aCGH. Conclusions With optimizing aCGH design and careful review process, aCGH can uncover intragenic deletions as small as dozen bases. These data provide insight that will help optimize probe coverage in array design and illustrate the true assay sensitivity. Mapping of the breakpoints confirms smaller deletions and contributes to the understanding of the mechanism behind these events. Our knowledge of the mutation spectra of several genes can be expected to change as previously unrecognized intragenic deletions are uncovered. PMID:24304607

[Gene Diagnosis and Analysis of Clinical Hematological Phenotype of Thailand Deleted α-Thalassemia 1].

PubMed

Lin, Na; Huang, Hai-Long; Wang, Yan; Zheng, Lin; Fang, Xiang-Qun; Cai, Mei-Ying; Wang, Lin-Shuo; Liu, He-Kun; Xu, Liang-Pu; Lin, Yuan

2016-08-01

To investigate the hematologic characteristics and gene diagnosis of patients with Thailand deleted α-thalassemia 1, so as to provide the information for clinical genetic counseling. The clinical data of 32 patients with Thailand delated α-thalassemia 1 were analyzed retrospectively; the hematologic characteristics and gene diagnosis of Thailand deleted type were investigated by using routine hematologic examination, genetic detection of common thalassemia and Thailand deleted α-thalassemia 1. Among 32 cases, the Thailand deleted α-thalassemia 1 heterozygote was found in 29 cases, the Thailand deleted α-thalassemia 1 and α(3.7) gene deletion double heterozygote were found in 1 case, the Thailand deleted α-thalassemia 1 with β-thalassemia (1 case with codons 41-42 mutation heterozygous, 1 case with CD17 mutation heterozygous) was found in 2 cases by detection. The MCV and MCH levels were decreased in all cases of Thailand deleted thalassemia 1, there were significant differences in RBC, MCV, MCH (P<0.05) between normal control and Thailand deletion α-thalassemia 1 group; there were also significant differences in MCHC (P<0.05) between Southeast asia thalassemia and Thailand deleted α-thalassemia 1 group. There are no significant differences in hematological parameters except MCHC between Southeast asia thalassemia and Thailand deleted α-thalassemia 1 group. moreover the Thailand deleted α-thalassemia 1 in a certain proportion exists in area with high incidence of thalassemia, therefor the clinicians should pay more attention to the screen and diagnosis of Thailand delated α-thalassemia and can exactly diagnose the Thailand delected α-thalassemia 1 on the basis of comprehensive analysis of conventional and Thailand delected α-thalassemia 1 detection results, clinical presentation, hematologic parameters and ultrasonic examination, so as to avoid the birth of child with severe and intermidiate type α-thalassemia caused by Thailand deleted α-thalassemia 1.

Deletion mapping of 22q11 in CATCH22 syndrome: Identification of a second critical region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurahashi, Hiroki; Nakayama, Takahiro; Nishisho, Isamu

1996-06-01

The deletion at 22q11.2 implicates a variety of congenital anomaly syndromes, for which the acronym CATCH22 has been proposed . Most patients with these syndromes share the common large deletion spanning 1-2 Mb, while the phenotypic variability of the patients does not seem to correlate with the extent of the deletions. On the basis of the deletions of rare cases with unbalanced translocation, the shortest region of overlap (SRO) had been identified in the most-centromeric region of the common large deletion. One patient (ADU) has been reported to carry a balanced translocation with the breakpoint located in the SRO. Recently,more » three transcripts were identified at or very close to the ADU breakpoint (ADUBP), making them strong candidates for CATCH22 syndrome. Here, we describe one patient with a unique deletion at 22q11.2 revealed by quantitative hybridization and/or FISH with six DNA markers in the common large deletion. The patient was dizygous at loci within the SRO and hemizygous only at the most-telomeric locus in the common large deletion. This finding suggests that there must be another critical region in the common large deletion besides the breakpoint of the ADU and that haploinsufficiency of genes in this deletion may also play a major role in CATCH22 pathogenesis. 15 refs., 3 figs.« less

A high-throughput method for the detection of homoeologous gene deletions in hexaploid wheat

PubMed Central

2010-01-01

Background Mutational inactivation of plant genes is an essential tool in gene function studies. Plants with inactivated or deleted genes may also be exploited for crop improvement if such mutations/deletions produce a desirable agronomical and/or quality phenotype. However, the use of mutational gene inactivation/deletion has been impeded in polyploid plant species by genetic redundancy, as polyploids contain multiple copies of the same genes (homoeologous genes) encoded by each of the ancestral genomes. Similar to many other crop plants, bread wheat (Triticum aestivum L.) is polyploid; specifically allohexaploid possessing three progenitor genomes designated as 'A', 'B', and 'D'. Recently modified TILLING protocols have been developed specifically for mutation detection in wheat. Whilst extremely powerful in detecting single nucleotide changes and small deletions, these methods are not suitable for detecting whole gene deletions. Therefore, high-throughput methods for screening of candidate homoeologous gene deletions are needed for application to wheat populations generated by the use of certain mutagenic agents (e.g. heavy ion irradiation) that frequently generate whole-gene deletions. Results To facilitate the screening for specific homoeologous gene deletions in hexaploid wheat, we have developed a TaqMan qPCR-based method that allows high-throughput detection of deletions in homoeologous copies of any gene of interest, provided that sufficient polymorphism (as little as a single nucleotide difference) amongst homoeologues exists for specific probe design. We used this method to identify deletions of individual TaPFT1 homoeologues, a wheat orthologue of the disease susceptibility and flowering regulatory gene PFT1 in Arabidopsis. This method was applied to wheat nullisomic-tetrasomic lines as well as other chromosomal deletion lines to locate the TaPFT1 gene to the long arm of chromosome 5. By screening of individual DNA samples from 4500 M2 mutant wheat lines generated by heavy ion irradiation, we detected multiple mutants with deletions of each TaPFT1 homoeologue, and confirmed these deletions using a CAPS method. We have subsequently designed, optimized, and applied this method for the screening of homoeologous deletions of three additional wheat genes putatively involved in plant disease resistance. Conclusions We have developed a method for automated, high-throughput screening to identify deletions of individual homoeologues of a wheat gene. This method is also potentially applicable to other polyploidy plants. PMID:21114819

UCP2 and 3 deletion screening and distribution in 15 pig breeds.

PubMed

Li, Yanhua; Li, Hanjie; Zhao, Xingbo; Li, Ning; Wu, Changxin

2007-02-01

The uncoupling protein family is a mitochondrial anion carrier family. It plays an important role in the biological traits of animal body weight, basal metabolic rate and energy conversion. Using PCR and PCR-SSCP, we scanned the porcine uncoupling protein 2 gene (UCP2) and uncoupling protein 3 gene (UCP3) and found seven deletion sites, three in UCP2 and four in UCP3. The deletions in 15 pig breeds showed that deletion influenced weight. The genotype compounding of seven deletion sites in 15 pig breeds had significant effects on performance traits of the pig, such as body weight. We predicted the potential protein factor binding sites using the transcription factor analysis tool TFSearch version 1.3 online. Two deletions (1830 nt and 3219 nt) in UCP3 were found to change the transcriptional factor sites. The 16 bp deletion in 1830 nt added a SP1 site and a 6 bp deletion in 3219 nt removed two MZF1 sites. Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 and UCP3, showing that UCPs have conservation and genetic reliability.

Early thermal testing of type B radioactive material packages in USA to environments beyond regulatory package thermal test standards

DOE PAGES

Yoshimura, H. R.; Pope, R. B.; Kubo, M.

2007-06-01

Three separate fire test programmes exposing casks beyond the regulatory thermal test requirements were performed by Sandia National Laboratories during the late 1970s and mid 1980s. The results of these test programmes can be used to assist in addressing the adequacy of the regulatory thermal test of fully engulfing exposure at 800°C for 30 min and how that test might relate to real accident thermal environments. The test programmes were undertaken on obsolete and new casks on behalf of the US Department of Energy (DOE), the US Department of Transportation (DOT) and the Japanese Power Reactor and Nuclear Fuel Developmentmore » Corporation (PNC), currently known as the Japan Atomic Energy Agency. Two of the tests involved exposure of casks in damaged transport vehicles to fully engulfing fires for 72–125 min, and the other test involved four exposures of a cask to torch environments for 30 min. Much of the original documentation regarding these tests and their results is no longer readily available. The documents relating to these tests have been surveyed; this paper presents summaries from this survey of the tests and their results. Specifically, for the pool fire exposures, the temperatures measured in the flames of both exceeded the flame temperature required by the Transport Regulations; yet an obsolete 67 t cask endured 90 min of exposure before evidence of failure was detected, and a new cask endured the 72 min exposure while retaining its containment integrity. For the exposure of a modified obsolete cask to four different torch environments, the integrity of the cask was retained and the relative temperature increases within the cask were well within acceptable limits and well below the values that could be expected if the cask was exposed to the regulatory thermal test. In this paper, a review of these three thermal test programmes, establishes that the two older cask designs and one new cask design have the ability to survive environments that were different from (the torch environments) or more severe than the environment specified by the existing thermal test requirement in the Transport Regulations. Finally, these results can be extrapolated to apply to modern casks that generally have more robust designs as well as better quality assurance applied during the manufacturing process.« less

mtDNA control-region sequence variation suggests multiple independent origins of an "Asian-specific" 9-bp deletion in sub-Saharan Africans.

PubMed Central

Soodyall, H.; Vigilant, L.; Hill, A. V.; Stoneking, M.; Jenkins, T.

1996-01-01

The intergenic COII/tRNA(Lys) 9-bp deletion in human mtDNA, which is found at varying frequencies in Asia, Southeast Asia, Polynesia, and the New World, was also found in 81 of 919 sub-Saharan Africans. Using mtDNA control-region sequence data from a subset of 41 individuals with the deletion, we identified 22 unique mtDNA types associated with the deletion in Africa. A comparison of the unique mtDNA types from sub-Saharan Africans and Asians with the 9-bp deletion revealed that sub-Saharan Africans and Asians have sequence profiles that differ in the locations and frequencies of variant sites. Both phylogenetic and mismatch-distribution analysis suggest that 9-bp deletion arose independently in sub-Saharan Africa and Asia and that the deletion has arisen more than once in Africa. Within Africa, the deletion was not found among Khoisan peoples and was rare to absent in western and southwestern African populations, but it did occur in Pygmy and Negroid populations from central Africa and in Malawi and southern African Bantu-speakers. The distribution of the 9-bp deletion in Africa suggests that the deletion could have arisen in central Africa and was then introduced to southern Africa via the recent "Bantu expansion." PMID:8644719

The fate of deleted DNA produced during programmed genomic deletion events in Tetrahymena thermophila.

PubMed Central

Saveliev, S V; Cox, M M

1994-01-01

Thousands of DNA deletion events occur during macronuclear development in the ciliate Tetrahymena thermophila. In two deleted genomic regions, designated M and R, the eliminated sequences form circles that can be detected by PCR. However, the circles are not normal products of the reaction pathway. The circular forms occur at very low levels in conjugating cells, but are stable. Sequencing analysis showed that many of the circles (as many as 50% of those examined) reflected a precise deletion in the M and R regions. The remaining circles were either smaller or larger and contained varying lengths of sequences derived from the chromosomal DNA surrounding the eliminated region. The chromosomal junctions left behind after deletion were more precise, although deletions in either the M or R regions can generate any of several alternative junctions (1). Some new chromosomal junctions were detected in the present study. The results suggest that the deleted segment is released as a linear DNA species that is degraded rapidly. The species is only rarely converted to the stable circles we detect. The deletion mechanism is different from those proposed for deletion events in hypotrichous ciliates (2-4), and does not reflect a conservative site-specific recombination process such as that promoted by the bacteriophage lambda integrase (5). Images PMID:7838724

Recurrence and variability of germline EPCAM deletions in Lynch syndrome.

PubMed

Kuiper, Roland P; Vissers, Lisenka E L M; Venkatachalam, Ramprasath; Bodmer, Danielle; Hoenselaar, Eveline; Goossens, Monique; Haufe, Aline; Kamping, Eveline; Niessen, Renée C; Hogervorst, Frans B L; Gille, Johan J P; Redeker, Bert; Tops, Carli M J; van Gijn, Marielle E; van den Ouweland, Ans M W; Rahner, Nils; Steinke, Verena; Kahl, Philip; Holinski-Feder, Elke; Morak, Monika; Kloor, Matthias; Stemmler, Susanne; Betz, Beate; Hutter, Pierre; Bunyan, David J; Syngal, Sapna; Culver, Julie O; Graham, Tracy; Chan, Tsun L; Nagtegaal, Iris D; van Krieken, J Han J M; Schackert, Hans K; Hoogerbrugge, Nicoline; van Kessel, Ad Geurts; Ligtenberg, Marjolijn J L

2011-04-01

Recently, we identified 3' end deletions in the EPCAM gene as a novel cause of Lynch syndrome. These truncating EPCAM deletions cause allele-specific epigenetic silencing of the neighboring DNA mismatch repair gene MSH2 in tissues expressing EPCAM. Here we screened a cohort of unexplained Lynch-like families for the presence of EPCAM deletions. We identified 27 novel independent MSH2-deficient families from multiple geographical origins with varying deletions all encompassing the 3' end of EPCAM, but leaving the MSH2 gene intact. Within The Netherlands and Germany, EPCAM deletions appeared to represent at least 2.8% and 1.1% of the confirmed Lynch syndrome families, respectively. MSH2 promoter methylation was observed in epithelial tissues of all deletion carriers tested, thus confirming silencing of MSH2 as the causative defect. In a total of 45 families, 19 different deletions were found, all including the last two exons and the transcription termination signal of EPCAM. All deletions appeared to originate from Alu-repeat mediated recombination events. In 17 cases regions of microhomology around the breakpoints were found, suggesting nonallelic homologous recombination as the most likely mechanism. We conclude that 3' end EPCAM deletions are a recurrent cause of Lynch syndrome, which should be implemented in routine Lynch syndrome diagnostics. © 2011 Wiley-Liss, Inc.

Impact of molecular mechanisms, including deletion size, on Prader-Willi syndrome phenotype: study of 75 patients.

PubMed

Varela, M C; Kok, F; Setian, N; Kim, C A; Koiffmann, C P

2005-01-01

Prader-Willi syndrome (PWS) can result from a 15q11-q13 paternal deletion, maternal uniparental disomy (UPD), or imprinting mutations. We describe here the phenotypic variability detected in 51 patients with different types of deletions and 24 patients with UPD. Although no statistically significant differences could be demonstrated between the two main types of PWS deletion patients, it was observed that type I (BP1-BP3) patients acquired speech later than type II (BP2-BP3) patients. Comparing the clinical pictures of our patients with UPD with those with deletions, we found that UPD children presented with lower birth length and started walking earlier and deletion patients presented with a much higher incidence of seizures than UPD patients. In addition, the mean maternal age in the UPD group was higher than in the deletion group. No statistically significant differences could be demonstrated between the deletion and the UPD group with respect to any of the major features of PWS. In conclusion, our study did not detect significant phenotypic differences among type I and type II PWS deletion patients, but it did demonstrate that seizures were six times more common in patients with a deletion than in those with UPD.

Molecular characterization of NRXN1 deletions from 19,263 clinical microarray cases identifies exons important for neurodevelopmental disease expression

PubMed Central

Lowther, Chelsea; Speevak, Marsha; Armour, Christine M.; Goh, Elaine S.; Graham, Gail E.; Li, Chumei; Zeesman, Susan; Nowaczyk, Malgorzata J.M.; Schultz, Lee-Anne; Morra, Antonella; Nicolson, Rob; Bikangaga, Peter; Samdup, Dawa; Zaazou, Mostafa; Boyd, Kerry; Jung, Jack H.; Siu, Victoria; Rajguru, Manjulata; Goobie, Sharan; Tarnopolsky, Mark A.; Prasad, Chitra; Dick, Paul T.; Hussain, Asmaa S.; Walinga, Margreet; Reijenga, Renske G.; Gazzellone, Matthew; Lionel, Anath C.; Marshall, Christian R.; Scherer, Stephen W.; Stavropoulos, Dimitri J.; McCready, Elizabeth; Bassett, Anne S.

2016-01-01

Purpose The purpose of the current study was to assess the penetrance of NRXN1 deletions. Methods We compared the prevalence and genomic extent of NRXN1 deletions identified among 19,263 clinically referred cases to that of 15,264 controls. The burden of additional clinically relevant CNVs was used as a proxy to estimate the relative penetrance of NRXN1 deletions. Results We identified 41 (0.21%) previously unreported exonic NRXN1 deletions ascertained for developmental delay/intellectual disability, significantly greater than in controls [OR=8.14 (95% CI 2.91–22.72), p< 0.0001)]. Ten (22.7%) of these had a second clinically relevant CNV. Subjects with a deletion near the 3′ end of NRXN1 were significantly more likely to have a second rare CNV than subjects with a 5′ NRXN1 deletion [OR=7.47 (95% CI 2.36–23.61), p=0.0006]. The prevalence of intronic NRXN1 deletions was not statistically different between cases and controls (p=0.618). The majority (63.2%) of intronic NRXN1 deletion cases had a second rare CNV, a two-fold greater prevalence than for exonic NRXN1 deletion cases (p=0.0035). Conclusions The results support the importance of exons near the 5′ end of NRXN1 in the expression of neurodevelopmental disorders. Intronic NRXN1 deletions do not appear to substantially increase the risk for clinical phenotypes. PMID:27195815

Assessment of the frequency of the 22q11 deletion in Afrikaner schizophrenic patients.

PubMed

Wiehahn, G J; Bosch, G P; du Preez, R R; Pretorius, H W; Karayiorgou, M; Roos, J L

2004-08-15

A hemizygous deletion of the q11 band on chromosome 22 occurs in 1 of every 5,950 live births (0.017%). The deletion is mediated by low copy repeats (LCRs) flanking this locus. Presence of the deletion is associated with variable phenotypic expression, which can include distinctive facial dysmorphologies, congenital heart disease and learning disabilities. An unusually high percentage of individuals with this deletion (25-30%) have been described to develop schizophrenia or schizoaffective disorder. In previous studies, the prevalence of the 22q11 deletion in patients with schizophrenia was found to be approximately 2% in Caucasian adults and 6% in childhood-onset cases. Both these frequencies represent a dramatic increase from the prevalence of the deletion in the general population. In this study, we investigate the occurrence of the 22q11 deletion in an independent sample of schizophrenic patients of Afrikaner origin. We first ascertained a sample of 85 patients who meet full diagnostic criteria for schizophrenia for presence of two or more of the clinical features associated with presence of the 22q11 deletion. A group of six patients (7%) met these criteria. This group was subjected to fluorescent in situ hybridization (FISH) and presence of the 22q11 deletion was confirmed for two subjects. Our study therefore confirms the previously reported rate of 2% frequency of the 22q11 deletion in adult schizophrenic patients and provides a two-stage screening protocol to identify these patients. Copyright 2004 Wiley-Liss, Inc.

Novel large-range mitochondrial DNA deletions and fatal multisystemic disorder with prominent hepatopathy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bianchi, Marzia; Rizza, Teresa; Verrigni, Daniela

2011-11-18

Highlights: Black-Right-Pointing-Pointer Expanded array of mtDNA deletions. Black-Right-Pointing-Pointer Pearson syndrome with prominent hepatopathy associated with single mtDNA deletions. Black-Right-Pointing-Pointer Detection of deletions in fibroblasts and blood avoids muscle and liver biopsy. Black-Right-Pointing-Pointer Look for mtDNA deletions before to study nuclear genes related to mtDNA depletion. -- Abstract: Hepatic involvement in mitochondrial cytopathies rarely manifests in adulthood, but is a common feature in children. Multiple OXPHOS enzyme defects in children with liver involvement are often associated with dramatically reduced amounts of mtDNA. We investigated two novel large scale deletions in two infants with a multisystem disorder and prominent hepatopathy. Amount ofmore » mtDNA deletions and protein content were measured in different post-mortem tissues. The highest levels of deleted mtDNA were in liver, kidney, pancreas of both patients. Moreover, mtDNA deletions were detected in cultured skin fibroblasts in both patients and in blood of one during life. Biochemical analysis showed impairment of mainly complex I enzyme activity. Patients manifesting multisystem disorders in childhood may harbour rare mtDNA deletions in multiple tissues. For these patients, less invasive blood specimens or cultured fibroblasts can be used for molecular diagnosis. Our data further expand the array of deletions in the mitochondrial genomes in association with liver failure. Thus analysis of mtDNA should be considered in the diagnosis of childhood-onset hepatopathies.« less

Mucopolysaccharidosis type IVA: Common double deletion in the N-Acetylgalactosamine-6-sulfatase gene (GALNS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hori, Toshinori; Tomatsu, Shunji; Fukuda, Seiji

1995-04-10

Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder caused by a deficiency in N-acetylgalactosamine-6-sulfatase (GALNS). We found two separate deletions of nearly 8.0 and 6.0 kb in the GALNS gene, including some exons. There are Alu repetitive elements near the breakpoints of the 8.0-kb deletion, and this deletion resulted from an Alu-Alu recombination. The other 6.0-kb deletion involved illegitimate recombinational events between incomplete short direct repeats of 8 bp at deletion breakpoints. The same rearrangement has been observed in a heteroallelic state in four unrelated patients. This is the first documentation of a common double deletion a gene thatmore » is not a member of a gene cluster. 39 refs., 5 figs.« less

A Functional Element Necessary for Fetal Hemoglobin Silencing

PubMed Central

Sankaran, Vijay G.; Xu, Jian; Byron, Rachel; Greisman, Harvey A.; Fisher, Chris; Weatherall, David J.; Sabath, Daniel E.; Groudine, Mark; Orkin, Stuart H.; Premawardhena, Anuja; Bender, M.A.

2011-01-01

BACKGROUND An improved understanding of the regulation of the fetal hemoglobin genes holds promise for the development of targeted therapeutic approaches for fetal hemoglobin induction in the β-hemoglobinopathies. Although recent studies have uncovered trans-acting factors necessary for this regulation, limited insight has been gained into the cis-regulatory elements involved. METHODS We identified three families with unusual patterns of hemoglobin expression, suggestive of deletions in the locus of the β-globin gene (β-globin locus). We performed array comparative genomic hybridization to map these deletions and confirmed breakpoints by means of polymerase-chain-reaction assays and DNA sequencing. We compared these deletions, along with previously mapped deletions, and studied the trans-acting factors binding to these sites in the β-globin locus by using chromatin immunoprecipitation. RESULTS We found a new (δβ)0-thalassemia deletion and a rare hereditary persistence of fetal hemoglobin deletion with identical downstream breakpoints. Comparison of the two deletions resulted in the identification of a small intergenic region required for γ-globin (fetal hemoglobin) gene silencing. We mapped a Kurdish β0-thalassemia deletion, which retains the required intergenic region, deletes other surrounding sequences, and maintains fetal hemoglobin silencing. By comparing these deletions and other previously mapped deletions, we elucidated a 3.5-kb intergenic region near the 5′ end of the δ-globin gene that is necessary for γ-globin silencing. We found that a critical fetal hemoglobin silencing factor, BCL11A, and its partners bind within this region in the chromatin of adult erythroid cells. CONCLUSIONS By studying three families with unusual deletions in the β-globin locus, we identified an intergenic region near the δ-globin gene that is necessary for fetal hemoglobin silencing. (Funded by the National Institutes of Health and others.) PMID:21879898

Small Deletion Variants Have Stable Breakpoints Commonly Associated with Alu Elements

PubMed Central

Coin, Lachlan J. M.; Steinfeld, Israel; Yakhini, Zohar; Sladek, Rob; Froguel, Philippe; Blakemore, Alexandra I. F.

2008-01-01

Copy number variants (CNVs) contribute significantly to human genomic variation, with over 5000 loci reported, covering more than 18% of the euchromatic human genome. Little is known, however, about the origin and stability of variants of different size and complexity. We investigated the breakpoints of 20 small, common deletions, representing a subset of those originally identified by array CGH, using Agilent microarrays, in 50 healthy French Caucasian subjects. By sequencing PCR products amplified using primers designed to span the deleted regions, we determined the exact size and genomic position of the deletions in all affected samples. For each deletion studied, all individuals carrying the deletion share identical upstream and downstream breakpoints at the sequence level, suggesting that the deletion event occurred just once and later became common in the population. This is supported by linkage disequilibrium (LD) analysis, which has revealed that most of the deletions studied are in moderate to strong LD with surrounding SNPs, and have conserved long-range haplotypes. Analysis of the sequences flanking the deletion breakpoints revealed an enrichment of microhomology at the breakpoint junctions. More significantly, we found an enrichment of Alu repeat elements, the overwhelming majority of which intersected deletion breakpoints at their poly-A tails. We found no enrichment of LINE elements or segmental duplications, in contrast to other reports. Sequence analysis revealed enrichment of a conserved motif in the sequences surrounding the deletion breakpoints, although whether this motif has any mechanistic role in the formation of some deletions has yet to be determined. Considered together with existing information on more complex inherited variant regions, and reports of de novo variants associated with autism, these data support the presence of different subgroups of CNV in the genome which may have originated through different mechanisms. PMID:18769679

Sequence family variant loss from the AZFc interval of the human Y chromosome, but not gene copy loss, is strongly associated with male infertility

PubMed Central

Machev, N; Saut, N; Longepied, G; Terriou, P; Navarro, A; Levy, N; Guichaoua, M; Metzler-Guillemai..., C; Collignon, P; Frances, A; Belougne, J; Clemente, E; Chiaroni, J; Chevillard, C; Durand, C; Ducourneau, A; Pech, N; McElreavey, K; Mattei, M; Mitchell, M

2004-01-01

Background: Complete deletion of the complete AZFc interval of the Y chromosome is the most common known genetic cause of human male infertility. Two partial AZFc deletions (gr/gr and b1/b3) that remove some copies of all AZFc genes have recently been identified in infertile and fertile populations, and an association study indicates that the resulting gene dose reduction represents a risk factor for spermatogenic failure. Methods: To determine the incidence of various partial AZFc deletions and their effect on fertility, we combined quantitative and qualitative analyses of the AZFc interval at the DAZ and CDY1 loci in 300 infertile men and 399 control men. Results: We detected 34 partial AZFc deletions (32 gr/gr deletions), arising from at least 19 independent deletion events, and found gr/gr deletion in 6% of infertile and 3.5% of control men (p>0.05). Our data provide evidence for two large AZFc inversion polymorphisms, and for relative hot and cold spots of unequal crossing over within the blocks of homology that mediate gr/gr deletion. Using SFVs (sequence family variants), we discriminate DAZ1/2, DAZ3/4, CDY1a (proximal), and CDY1b (distal) and define four types of DAZ-CDY1 gr/gr deletion. Conclusions: The only deletion type to show an association with infertility was DAZ3/4-CDY1a (p = 0.042), suggesting that most gr/gr deletions are neutral variants. We see a stronger association, however, between loss of the CDY1a SFV and infertility (p = 0.002). Thus, loss of this SFV through deletion or gene conversion could be a major risk factor for male infertility. PMID:15520406

The preS deletion of hepatitis B virus (HBV) is associated with liver fibrosis progression in patients with chronic HBV infection.

PubMed

Li, Fan; Li, Xiaodong; Yan, Tao; Liu, Yan; Cheng, Yongqian; Xu, Zhihui; Shao, Qing; Liao, Hao; Huang, Pengyu; Li, Jin; Chen, Guo-Feng; Xu, Dongping

2018-03-01

Limited data are available regarding the association of hepatitis B virus (HBV) mutations with liver fibrosis in HBV infection. The study aimed to clarify whether HBV preS deletion mutation is associated with liver fibrosis progression. A total of 469 patients were enrolled, including 324 with chronic hepatitis B (CHB), 28 with HBV-related compensated liver cirrhosis (LC), and 117 with HBV-related decompensated LC. All CHB and compensated LC patients received liver biopsy. Fibrosis grade was assessed using METAVIR score. HBV preS deletion was determined by direct sequencing and verified by clonal sequencing. Overall preS deletion was detected in 12.6% (59/469) patients, specifically, in 7.51% (13/173), 10.60% (16/151), and 20.69% (30/145) of patients with no-to-mild liver fibrosis (F0-1), moderate-to-severe liver fibrosis (F2-3), and cirrhosis (F4), respectively (p < 0.01). Patients with preS-deleted HBV had lower serum HBV DNA and albumin levels compared to patients with wild-type HBV. The median length of preS deletion was 39-base pairs (bp) (3-204 bp) and the deletion most frequently emerged in preS2 initial region. Multivariate analysis identified the preS2 deletion rather than preS1 deletion to be an independent risk factor of significant fibrosis, i.e., METAVIR F ≥ 2 (p = 0.007). In addition, preS-deleted viral sequences were detected in the pool of intrahepatic HBV covalently closed circular DNA. HBV preS deletion is positively associated with liver fibrosis progression in chronic HBV-infected patients. HBV preS2 deletion may serve as a warning indicator for liver fibrosis progression.

Zoom‐in comparative genomic hybridisation arrays for the characterisation of variable breakpoint contiguous gene syndromes

PubMed Central

Johnston, Jennifer J; Walker, Robert L; Davis, Sean; Facio, Flavia; Turner, Joyce T; Bick, David P; Daentl, Donna L; Ellison, Jay W; Meltzer, Paul S; Biesecker, Leslie G

2007-01-01

Contiguous gene syndromes cause disorders via haploinsufficiency for adjacent genes. Some contiguous gene syndromes (CGS) have stereotypical breakpoints, but others have variable breakpoints. In CGS that have variable breakpoints, the extent of the deletions may be correlated with severity. The Greig cephalopolysyndactyly contiguous gene syndrome (GCPS‐CGS) is a multiple malformation syndrome caused by haploinsufficiency of GLI3 and adjacent genes. In addition, non‐CGS GCPS can be caused by deletions or duplications in GLI3. Although fluorescence in situ hybridisation (FISH) can identify large deletion mutations in patients with GCPS or GCPS‐CGS, it is not practical for identification of small intragenic deletions or insertions, and it is difficult to accurately characterise the extent of the large deletions using this technique. We have designed a custom comparative genomic hybridisation (CGH) array that allows identification of deletions and duplications at kilobase resolution in the vicinity of GLI3. The array averages one probe every 730 bp for a total of about 14 000 probes over 10 Mb. We have analysed 16 individuals with known or suspected deletions or duplications. In 15 of 16 individuals (14 deletions and 1 duplication), the array confirmed the prior results. In the remaining patient, the normal CGH array result was correct, and the prior assessment was a false positive quantitative polymerase chain reaction result. We conclude that high‐density CGH array analysis is more sensitive than FISH analysis for detecting deletions and provides clinically useful results on the extent of the deletion. We suggest that high‐density CGH array analysis should replace FISH analysis for assessment of deletions and duplications in patients with contiguous gene syndromes caused by variable deletions. PMID:17098889

NF1 Microdeletion Syndrome: Refined FISH Characterization of Sporadic and Familial Deletions with Locus-Specific Probes

PubMed Central

Riva, Paola; Corrado, Lucia; Natacci, Federica; Castorina, Pierangela; Wu, Bai-Li; Schneider, Gretchen H.; Clementi, Maurizio; Tenconi, Romano; Korf, Bruce R.; Larizza, Lidia

2000-01-01

Summary Two familial and seven sporadic patients with neurofibromatosis 1—who showed dysmorphism, learning disabilities/mental retardation, and additional signs and carried deletions of the NF1 gene—were investigated by use of a two-step FISH approach to characterize the deletions. With FISH of YAC clones belonging to a 7-Mb 17q11.2 contig, we estimated the extension of all of the deletions and identified the genomic regions harboring the breakpoints. Mosaicism accounted for the mild phenotype in two patients. In subsequent FISH experiments, performed with locus-specific probes generated from the same YACs by means of a novel procedure, we identified the smallest region of overlapping (SRO), mapped the deletion breakpoints, and identified the genes that map to each deletion interval. From centromere to telomere, the ∼0.8-Mb SRO includes sequence-tagged site 64381, the SUPT6H gene (encoding a transcription factor involved in chromatin structure), and NF1. Extending telomerically from the SRO, two additional genes—BLMH, encoding a hydrolase involved in bleomycin resistance, and ACCN1, encoding an amiloride-sensitive cation channel expressed in the CNS—were located in the deleted intervals of seven and three patients, respectively. An apparently common centromeric deletion breakpoint was shared by all of the patients, whereas a different telomeric breakpoint defined a deletion interval of 0.8–3 Mb. There was no apparent correlation between the extent of the deletion and the phenotype. This characterization of gross NF1 deletions provides the premise for addressing correctly any genotype-phenotype correlation in the subset of patients with NF1 deletions. PMID:10631140

Identification of novel deletions of 15q11q13 in Angelman syndrome by array-CGH: molecular characterization and genotype-phenotype correlations.

PubMed

Sahoo, Trilochan; Bacino, Carlos A; German, Jennifer R; Shaw, Chad A; Bird, Lynne M; Kimonis, Virginia; Anselm, Irinia; Waisbren, Susan; Beaudet, Arthur L; Peters, Sarika U

2007-09-01

Angelman syndrome (AS) is a neurodevelopmental disorder characterized by mental retardation, absent speech, ataxia, and a happy disposition. Deletions of the 15q11q13 region are found in approximately 70% of AS patients. The deletions are sub-classified into class I and class II based on their sizes of approximately 6.8 and approximately 6.0, respectively, with two different proximal breakpoints and a common distal breakpoint. Utilizing a chromosome 15-specific comparative genomic hybridization genomic microarray (array-CGH), we have identified, determined the deletion sizes, and mapped the breakpoints in a cohort of 44 cases, to relate those breakpoints to the genomic architecture and derive more precise genotype-phenotype correlations. Interestingly four patients of the 44 studied (9.1%) had novel and unusually large deletions, and are reported here. This is the first report of very large deletions of 15q11q13 resulting in AS; the largest deletion being >10.6 Mb. These novel deletions involve three different distal breakpoints, two of which have been earlier shown to be involved in the generation of isodicentric 15q chromosomes (idic15). Additionally, precise determination of the deletion breakpoints reveals the presence of directly oriented low-copy repeats (LCRs) flanking the recurrent and novel breakpoints. The LCRs are adequate in size, orientation, and homology to enable abnormal recombination events leading to deletions and duplications. This genomic organization provides evidence for a common mechanism for the generation of both common and rare deletion types. Larger deletions result in a loss of several genes outside the common Angelman syndrome-Prader-Willi syndrome (AS-PWS) critical interval, and a more severe phenotype.

Early-onset obesity and paternal 2pter deletion encompassing the ACP1, TMEM18, and MYT1L genes.

PubMed

Doco-Fenzy, Martine; Leroy, Camille; Schneider, Anouck; Petit, Florence; Delrue, Marie-Ange; Andrieux, Joris; Perrin-Sabourin, Laurence; Landais, Emilie; Aboura, Azzedine; Puechberty, Jacques; Girard, Manon; Tournaire, Magali; Sanchez, Elodie; Rooryck, Caroline; Ameil, Agnès; Goossens, Michel; Jonveaux, Philippe; Lefort, Geneviève; Taine, Laurence; Cailley, Dorothée; Gaillard, Dominique; Leheup, Bruno; Sarda, Pierre; Geneviève, David

2014-04-01

Obesity is a common but highly, clinically, and genetically heterogeneous disease. Deletion of the terminal region of the short arm of chromosome 2 is rare and has been reported in about 13 patients in the literature often associated with a Prader-Willi-like phenotype. We report on five unrelated patients with 2p25 deletion of paternal origin presenting with early-onset obesity, hyperphagia, intellectual deficiency, and behavioural difficulties. Among these patients, three had de novo pure 2pter deletions, one presented with a paternal derivative der(2)t(2;15)(p25.3;q26) with deletion in the 2pter region and the last patient presented with an interstitial 2p25 deletion. The size of the deletions was characterized by SNP array or array-CGH and was confirmed by fluorescence in situ hybridization (FISH) studies. Four patients shared a 2p25.3 deletion with a minimal critical region estimated at 1.97 Mb and encompassing seven genes, namely SH3HYL1, ACP1, TMEMI8, SNTG2, TPO, PXDN, and MYT1L genes. The fifth patient had a smaller interstitial deletion encompassing the TPO, PXDN, and MYT1L genes. Paternal origin of the deletion was determined by genotyping using microsatellite markers. Analysis of the genes encompassed in the deleted region led us to speculate that the ACP1, TMEM18, and/or MYT1L genes might be involved in early-onset obesity. In addition, intellectual deficiency and behavioural troubles can be explained by the heterozygous loss of the SNTG2 and MYT1L genes. Finally, we discuss the parent-of-origin of the deletion.

Numerical Simulations of Asymmetric Mixing in Planar Shear Flows.

DTIC Science & Technology

1985-08-23

S. Oran 202 767-296 10oe44 00. FORM 1473,84 MAR 83 APR edition may be used until exhausted All other editions are obsolete SECURITY CLASSIFICATION OF...first is developing the numerical model that was used in these studies. In particular, we are concerned with the treatment of inflow and outflow...boundary conditions suitable for both compressible and incompressible flows. The second aspect is using this model to describe shear flows in a splitter

A Fault Tolerant Self-Routing Computer Network Topology

DTIC Science & Technology

1987-01-01

Herr and Thomas J. Plevyak, *ISDN: The Opportunity Beginso, IEEECommunicationsMaqaz I t, pp. 6-10, November 1986. 5. Mario Gerla and Rodolfo A . Pazos ...WOLAVER a Dean for Research anProfessional Development Air Force Institute Bf Technology Wright-Patterson AFB OH 45433-6583 19. KEY WORDS (Continue...DD I 1473 EDITION OF I NOV 65 IS OBSOLETE UM!C[ASSIFIEy SECURITY CLASSIFICATION OF THIS PAGE (When Data Entered) 41 ,." 5.’ A Fault Tolerant Self

Military Families with Handicapped Children: The Reassignment Problem

DTIC Science & Technology

1981-02-01

of them ( education service center, Lub- bock Medical facilities , Lubbock State School, psychiatric facilities , etc.) 18. Additional comments: Rapidly...Attached DD ) AN 73 1473 EDITION OF I NOV6GS IS OBSOLETE UNCL 23 Oct 81 8 1 10 2oc 0 6 2 !CURITY CLASSIFICATION OF THIS PAGE (I7,n Data Entered) AIR WAR...COLLEGE AIR UNIVERSITY Report No. MS107-81 MILITARY FAMILIES WITH HANDICAPPED CHILDREN: THE REASSIGNMENT PROBLEM (A (WiDE TO SPECIAL EDUCATION AVAILABLE

Studies of Phlebotomine Sand Flies.

DTIC Science & Technology

1981-05-01

20, It different from Report) IS. SUPPLEMENTARY NOTES 9’. KEY WOFDS (Continue an teers*e aide it necessa y mid identify by block number) Lutzomyia ...illustrations and a description of a new species. Other new Lutzomyia sand flies were discovered in Mexico and Ecuador. A species group of Lutzomyia ...egg structure of some Lutzomyia D IN J OBSOLETE Continued-- / ’DD , j. 1473 EtnT oN OFNvS = LT Unclaggi;fi;R~d y - SECURITY CLASSIFICA rIOm OF THIS

Word Frequency Analysis. MOS: 19F. Skill Levels 1 & 2.

DTIC Science & Technology

1981-05-01

NUMBER(a) Dr. Alexander A. Longo 9. PERFORMING ORGANIZATION NAME AND ADCRESS 10. PROGRAM ELEMENT, PROJECT, TASK AREA 4 WORK UNIT NUMSERS Training ...Developments Institute ATTN: ATTG-DOR Fort Monroe, VA 23651 -- It. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE Training Developments Institute IAvJ...JAW 73 1473 EInON OF I NOV 6S IS OBSOLETE SECURITY CLASSIFICATION O F Tl)lS PAGE (ifNe Dote Entered) Contents and General Information 1. The Word

U.S. Security Assistance Programs in Southern Africa: Are They Supporting National Objectives?

DTIC Science & Technology

1985-04-01

YIO (Include .-iea Codi’, SACS ’-/uLLCC IaxwelI AFB Al- 36112 (205) 293-2483 UL) j7 ()phi 1473 33 AV",, EDITION OF 1 JAN 73 IS OBSOLETE, -UJLASSIF lED...34 (8: p. 6-9) Th e CPD is soml~etimes re-ferred to as the Consolidated Data Report and is I-.ral ly an u..pdate of the AISA The heart of the AIASA is

A Study of Styrene-Butadiene Rubber Blends as Improved Flame Agents

DTIC Science & Technology

1976-06-01

results of air gun tests. Thus, both elasticity and viscosity must be considered when DD I JAN 7 1473 EDITION OF I NOV 63 IS OBSOLETE UNCLASSIFIED sECURITy...L.EGEND!~ 23.9’ C 0~ 1:? 100 >.80 I.. 20 ini Sha at)sc Fiue2. Prcn eoyof2-ecnSR4/0a Vaiu aisa 38 227 I LI I : hi Ilii Al 01 100 130 6n0 40- Shear Rate

DOD Methodology for the Valuation of Excess, Obsolete, and Unserviceable Inventory and Operating Materials and Supplies

DTIC Science & Technology

2010-03-25

PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES...AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11. SPONSOR/MONITOR’S REPORT NUMBER( S ) 12. DISTRIBUTION/AVAILABILITY STATEMENT...Unserviceable FMR Financial Management Regulation OM& S Operating Materials and Supplies SFFAS Statement of Federal Financial Accounting Standards

Combatting Terrorism: A Guide for U. S. Naval Forces Afloat

DTIC Science & Technology

1985-12-01

weaponry at an alarming rate . Because of this progress "large numbers of these new weapons will quickly become obsolete and disposed of through arms... rate qualification processes. Consequently, it is many times given to an -: inexperienced, new individual while "more important" posi- 0A * tions are...so as not to unduly tax the regular training schedule. While the training of the crew in anti-terrorist and counterterrorist techniques is in progress

Is Textbook Obsolete in New Education? A Critical Analysis on the Value of Textbook in an Inquiry Curriculum, with Special Reference to the New Primary General Studies Curriculum in Hong Kong

ERIC Educational Resources Information Center

Angus, Chan Hok

2004-01-01

The new Primary General Studies (GS) is a landmark of the curriculum reform in Hong Kong. Since year 2001 the local education authority launched the curriculum reform by issuing the "learning to learn" (CDC 2001) document, the curriculum of almost all subjects have been amended or even totally revised to fulfill the spirit of the new…

International Technology Transfer the Rope to Hang the West

DTIC Science & Technology

1989-03-28

order to provide awareness and appreciation of its importance to the security of the United States. DO R 1473 EOfTION OF V NOV 65 I.; OBSOLETE E - 7I... e Data Eme’e, USAWC MILITARY STUDIES PROGRAM PAPER INTERNATIONAL TECHNOLOGY TRANSFER The Rope To Hang The West AN INDIVIDUAL STUDY PROJECT Intended...notably the Departments of State, Commerce and Defense), and other friendly nations at odds with each other over competing demands and parochial interests

Collisionless Coupling in the AMPTE (Active Magnetospheric Particle Tracer Explorers) Artificial Comet.

DTIC Science & Technology

1986-09-29

34." J. D. HUBA e . Geophysical and Plasma Dynamics Branch .. .. Plasma Physics Division .- - -’ Applied Physics Laboratory Johns Hopkins University Laurel...reverse if necessnary and identify by block number) e Analysis of previously reported observations of the solar wind barium interaction associated with...83 APR ed,tion may be used until exhausted SECURITY CLASSIFICATION OF THIS PAGE All other editions are obsolete #ALL 0. ft"" e ~ Wiism "go-aew

Development of Biodegradable Implants for Use in Maxillofacial Surgery

DTIC Science & Technology

1988-09-23

Previous edit,ons are obsolete EC1_4 ’ Y C ,S ’iCAT ON OF 7±5S aGE I"L{..-. { ~; ABBREVIATIONS poly(DL-lactide) (DL-PLA) poly(L-lactide) (L-PLA...modulus of L-PLA plates ........... ......................... 53 13 Non-coated hydroxyapatite particles after drying .............. 59 14 Hydroxyapatite ...77 (continued) ix LIST OF FIGURES (continued) Fieure age 23 Drawing No. 1 scale: 1/2" - 1" iaterial:alumina (99.7% A1203

Computer Description of the M561 Utility Truck

DTIC Science & Technology

1984-10-01

GIFT Computer Code Sustainabi1ity Predictions for Army Spare Components Requirements for Combat (SPARC) 20. ABSTRACT (Caotfmia «a NWM eitim ft...used as input to the GIFT computer code to generate target vulnerability data. DO FORM V JAM 73 1473 EDITION OF I NOV 65 IS OBSOLETE Unclass i f ied...anaLyiis requires input from the Geometric Information for Targets ( GIFT ) ’ computer code. This report documents the combina- torial geometry (Com-Geom

Revegetation Study of Adobe Dam, Phoenix, Arizona. Task 2. Revision.

DTIC Science & Technology

1983-08-01

revegetation. *~ ~ A DDoa or?, I47 MDTOOOV 65IS OBSOLETE SECURITY CLASSIFICATION OF THIS PAGE (Wh"e Ders, Enreedl k ’, ... . .- r77. -. r - -V...addition to sodic soils, five sites along the wash were discovered to have salinity problems, with electrical conductivity in excess of 4. mmhos/cm. This...established at Indian Bend Wash.This species, along with Salla kalL (Tumbleweed) made upthe majority of the vegetation in 1979. Since 1979, as thedata in

Development of a Calcifiable Matrix for Bone Formation.

DTIC Science & Technology

1987-09-01

Previous editions are obsolete. SECURITY CLASSIFICATION OF THIS PAGE 4 ! Ir .€ w)N "," f " f " W"€ r ,. . , a v " -.-. ,. . P "w...process is hydroxyapatite *o(15). It was the purpose of our study to determine if three different doses of -.ofour variations of the polypentapeptide...phosphate would bind until a cascading series of events led to calcium phosphate deposition and its conversion to hydroxyapatite . The validity of this

Industrial Technology Modernization Program. Project 20. Consolidation and Automation of Material and Tool Storage. Phase 2

DTIC Science & Technology

1987-06-15

GENERAL DYNAMICS FORT WORTH DIVISION INDUSTRIAL TECHNOLOGY00 N MODERNIZATION PROGRAM Phase 2 Final Project Report DT C JUNO 7 1989J1K PROJECT 20...CLASSIFICATION O THIS PAGE All other editions are obsolete. unclassified Honeywell JUNE 15, 1987 GENERAL DYNAMICS FORT WORTH DIVISION INDUSTRIAL ...SYSTEMIEQUIPMENT/MACHINING SPECIFICATIONS 33 9 VENDOR/ INDUSTRY ANALYSIS FINDING 39 10 MIS REQUIREMENTS/IMPROVEMENTS 45 11 COST BENEFIT ANALYSIS 48 12 IMPLEMENTATION

WATER PUMP HOUSE, TRA619, AND TWO WATER STORAGE RESERVOIRS. INDUSTRIAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

WATER PUMP HOUSE, TRA-619, AND TWO WATER STORAGE RESERVOIRS. INDUSTRIAL WINDOWS AND COPING STRIPS AT TOP OF WALLS AND ENTRY VESTIBULE. BOLLARDS PROTECT UNDERGROUND FACILITIES. SWITCHYARD AT RIGHT EDGE OF VIEW. CARD IN LOWER RIGHT WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON ORIGINAL NEGATIVE. INL NEGATIVE NO. 3816. Unknown Photographer, 11/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Honduras Defense Policy.

DTIC Science & Technology

1986-04-22

political, military, economic and social sectors. DO I JAN73 1473 EDITION OF I NOV GS IS OBSOLETE SECURITY CLASSIFICATION OF THIS PAGE (Wlen Data Entered...political military, economic and social sectors. NTIS CRA&I D -1 srl ooocB d Ju t l, atuo .. . By VI. lbut,.or / Availdbility Codes Dibt ,-.•or 0LIJ A...Pacific Ocean in the north and south, Honduras is the link that divides the Central American Isthmus in half. Any political, social or military event

An Artificial Neural Network Control System for Spacecraft Attitude Stabilization

DTIC Science & Technology

1990-06-01

NAVAL POSTGRADUATE SCHOOL Monterey, California ’-DTIC 0 ELECT f NMARO 5 191 N S, U, THESIS B . AN ARTIFICIAL NEURAL NETWORK CONTROL SYSTEM FOR...NO. NO. NO ACCESSION NO 11. TITLE (Include Security Classification) AN ARTIFICIAL NEURAL NETWORK CONTROL SYSTEM FOR SPACECRAFT ATTITUDE STABILIZATION...obsolete a U.S. G v pi.. iim n P.. oiice! toog-eo.5s43 i Approved for public release; distribution is unlimited. AN ARTIFICIAL NEURAL NETWORK CONTROL

A Global Solar Irradiance Climatology of an Intermountain Region.

DTIC Science & Technology

1986-01-01

D-A!171 97 A GLOBAL SOLAIR IRRRDIANCE CLIMATOLOGY OF AN INTERMOUNTAIN REGION(U) AIR FORCE INST OF TECH MRIGHT-PATTERSON APR ON E W DOBRY 1986...DD~ I JAN 73 1473 EDITION OF I NOV 65 IS OBSOLETE SECURITY CLASSIFICATION OF THIS PAGE Denfata E1ilered) %.ir.. , t . ~. ~ ~ ~ $~:V ( e vis ABSTRACT...Professor: Dr. G. E . Bingham De artment: Soil Science and Biometeorology A global solar irradiance climatology of an intermountain region is developed using

HAN (Hydroxylammonium Nitrate) Based Liquid Gun Propellants: Physical Properties

DTIC Science & Technology

1987-11-01

are obsolete UNCLASSIF IED UNCLASS IF IED 18. SUBJECT TERMS (con’t) Triethanolammonium Nitrate TEAN 19. ABSTRACT (con’t) The effect of the molecular...were synthesized and their viscosities and nsi1t9 deter,-ine.0d as a function of temperature. The results clearly show the effects of hydrogen bonding...on the physical properties. Surface tension and vapor pressure have been determined and an equation of state that accurately describes the effect of

Analysis of Low Bidding and Change Order Rates for Navy Facilities Construction Contracts.

DTIC Science & Technology

1984-06-01

examine his motives and strategies prior to bidding. Several measures of " level cf competitiveness" are introduced from bidding theory literature that...bidders of fixed-price Government construction contracts have on contract prices when the level FORM, 1473 EDITION OF INOV 6 o IS OBSOLETE S N 0 102...conventional measures of the . level of competition intensity are applied in regression and variance analyses. en, z e ., . , 144 , UNCLASSIFIED 2 SgCURITlY

Trainer Engineering Report (Final) for MILES. Volume 2. Revision

DTIC Science & Technology

1981-04-22

formerly a separate document, Data Item AOOX. iii/iv 1A , SECURITY CLASSIFICATION OF THIS PAGE (Uhen Deaa Enterecd) ... __ . ....... REPORT DOCUMENTATION...NAVTRAEQUIPCEN, Orlando, FL 32813 3 14. MON’TORING AGENCY NAME & ADDRESS(II dilletent from CoftrollIn OGlue*) IS. SECURITY CLASS. (of thie twoot...OBSOLETE UNCLASSIFIED S/N 0102蓞-6601 I SECURITY CL.ASSIFICATION OF THIS iPAGE fUlses Data EaieteE i • CONTENTS .I * INTRODUCTION 1-1 1.1 1980 MILES 1-1

Distributed Network Protocols

DTIC Science & Technology

1980-07-01

MONITORING AGENCY NAME & ADDRESS(II different from Controlting Office) IS. SECURITY CLASS. (of this report) S Office of Naval Research Unclassified...All protocols are extended to networks with changing. topology. S80 8 4 246 DD0I iA 1473 EDITION OF INOV 65 IS OBSOLETE 8 0 24 SECURITY CLASSIFICATION...to the netowrk . f) Each node knows its adjacent links, but not necessarily the identity of its neighbors, i.e. the nodes at the other end of the links

Resolving Inadequacies of the Navy Industrial Fund Cost Accounting System to Enable Its Use in the RAMP SMP (Rapid Acquisition of Manufactured Parts Small Manufactured Parts) Facility

DTIC Science & Technology

1988-12-01

maintenance, depreciation , rent, utilities, insurance, and taxes. 6 Historically, manufacturing activities have been labor intensive and man-paced...developed and produced which renders older equipment obsolete sooner. As a result, equipment must be replaced more frequently and depreciation is charged...McIlhattan, 1987). As previously mentioned, automated manufacturing activities incur greater amounts of depreciation expenses more rapidly than a

Electrically Erasable Programmable Integrated Circuits for Replacement of Obsolete TTL Logic

DTIC Science & Technology

1991-12-01

different discrete devices" [7]. Fowler-Nordheim Tunneling Simplified Theory. Electrons in polysilicon are usually prevented from entering SiO 2 by an...overcomes the energy barrier, the tunneling electrons will not return to the polysilicon but will be carried by the electric field, causing a current to flow...Floating Gate Transistors A floating gate transistor is an insulated-gate field effect transistor (FET) that has a gate, usually made of polysilicon , which

Comparison of growth, yield and fiber quality of the obsolete SA30 yellow leaf with four sets of modern yellow and green leaf near isogenic cotton (Gossypium hirsutum L.) lines

USDA-ARS?s Scientific Manuscript database

The Virescent Yellow leaf cotton line Seed Accession 30 (SA30) was crossed with four modern parental lines (DP5690, DES119, SG747 and MD51ne) to develop four sets of near isogenic lines (NILs) segregating for green and yellow leaves. Comparisons of these lines were made in the field in a two year re...

CrossTalk, The Journal of Defense Software Engineering. Volume 27, Number 3. May/June 2014

DTIC Science & Technology

2014-06-01

field of software engineering. by Delores M. Etter, Jennifer Webb, and John Howard The Problem of Prolific Process What is the optimal amount and...Programming Will Never Be Obsolete The creativity of software developers will always be needed to solve problems of the future and to then translate those...utilized to address some of the complex problems associated with biometric database construction. 1. A Next Generation Multispectral Iris Biometric

COMBATXXI, JDAFS, and LBC Integration Requirements for EASE

DTIC Science & Technology

2015-10-06

process as linear and as new data is made available, any previous analysis is obsolete and has to start the process over again. Figure 2 proposes a...final line of the manifest file names the scenario file associated with the run. Under the usual practice, the analyst now starts the COMBATXXI...describes which events are to be logged. Finally the scenario is started with the click of a button. The simulation generates logs of a couple of sorts

Instrumentation and Methodology for Generation of an Electrochemical Data Base for Pattern Recognition.

DTIC Science & Technology

1982-05-01

and mercury drop hang time all produced changes in cyclic differential capacity curves and -..-- DD 0A" 1473 EDITION OF 1 NOV 6S IS OBSOLETE S/N 0102...scan rate, and mercury drop hang time all produced changes in cyclic differential capacity curves and cyclic staircase voltammograms which were unique...Faradaic measurements with staircase voltammetry have been enumerated elewhere (24, 25). -4- EXPERIMENTAL Experimental Design The seven variables which

An Analysis of the Economic Assumptions Underlying Fiscal Plans FY1981 - FY1984.

DTIC Science & Technology

1986-06-01

OF THE ECONOMIC ASSUMPTIONS UNDERLYING FISCAL PLANS FY1981 - FY1984 by Robert Welch Beck June 1986 Thesis Advisor: P. M. CARRICK Approved for public ...DOWGRDIN SHEDLEApproved for public releace; it - 2b ECLSSIICAIONI DWNGAD G SHEDLEbut ion is unlimited. 4! PERFORMING ORGANIZATION REPORT NUMBER(S) S...SECURITY CLASSIFICATION OF T4𔃿 PAC~E All other editions are obsolete Approved for public release; distribution is unlimited. An Analysis of the

EXTENDING THE USEFUL LIFE OF OLDER MASS SPECTROMETERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, S.; Cordaro, J.; Holland, M.

2010-06-17

Thermal ionization and gas mass spectrometers are widely used across the Department of Energy (DOE) Complex and contractor laboratories. These instruments support critical missions, where high reliability and low measurement uncertainty are essential. A growing number of these mass spectrometers are significantly older than their original design life. The reality is that manufacturers have declared many of the instrument models obsolete, with direct replacement parts and service no longer available. Some of these obsolete models do not have a next generation, commercially available replacement. Today's budget conscious economy demands for the use of creative funds management. Therefore, the ability tomore » refurbish (or upgrade) these valuable analytical tools and extending their useful life is a cost effective option. The Savannah River Site (SRS) has the proven expertise to breathe new life into older mass spectrometers, at a significant cost savings compared to the purchase and installation of new instruments. A twenty-seven year old Finnigan MAT-261{trademark} Thermal Ionization Mass Spectrometer (TIMS), located at the SRS F/H Area Production Support Laboratory, has been successfully refurbished. Engineers from the Savannah River National Laboratory (SRNL) fabricated and installed the new electronics. These engineers also provide continued instrument maintenance services. With electronic component drawings being DOE Property, other DOE Complex laboratories have the option to extend the life of their aged Mass Spectrometers.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milovantseva, Natalia, E-mail: nmilovan@uci.edu; Saphores, Jean-Daniel, E-mail: saphores@uci.edu

Highlights: ► US households are storing 84.1 million broken or obsolete (junk) TVs. ► They represent 2.12 million metric tons of scrap. ► The value of these materials is approximately $21 per TV. ► Our count models characterize US households who store junk TVs. ► Our results are useful for designing more effective TV recycling programs. - Abstract: Within the growing stockpile of electronic waste (e-waste), TVs are especially of concern in the US because of their number (which is known imprecisely), their low recycling rate, and their material content: cathode ray tube televisions contain lead, and both rear projectionmore » and flat panel displays contain mercury, in addition to other potentially toxic materials. Based on a unique dataset from a 2010 survey, our count models show that pro-environmental behavior, age, education, household size, marital status, gender of the head of household, dwelling type, and geographic location are statistically significant variables for explaining the number of broken or obsolete (junk) TVs stored by US households. We also estimate that they are storing approximately 84.1 million junk TVs, which represents 40 pounds of scrap per household. Materials in each of these junk TVs are worth $21 on average at January 2012 materials prices, which sets an upper bound on collecting and recycling costs. This information should be helpful for developing more effective recycling strategies for TVs in the e-waste stream.« less

End-of-life (EoL) mobile phone management in Hong Kong households.

PubMed

Deng, Wen-Jing; Giesy, John P; So, C S; Zheng, Hai-Long

2017-09-15

A questionnaire survey and interviews were conducted in households and end-of-life (EoL) mobile phone business centres in Hong Kong. Widespread Internet use, combined with the rapid evolution of modern social networks, has resulted in the more rapid obsolescence of mobile phones, and thus a tremendous increase in the number of obsolete phones. In 2013, the volume of EoL mobile phones generated in Hong Kong totalled at least 330 tonnes, and the amount is rising. Approximately 80% of electronic waste is exported to Africa and developing countries such as mainland China or Pakistan for recycling. However, the material flow of the large number of obsolete phones generated by the territory's households remains unclear. Hence, the flow of EoL mobile phones in those households was analysed, with the average lifespan of a mobile phone in Hong Kong found to be just under two years (nearly 23 months). Most EoL mobile phones are transferred to mainland China for disposal. Current recycling methods are neither environmentally friendly nor sustainable, with serious implications for the environment and human health. The results of this analysis provide useful information for planning the collection system and facilities needed in Hong Kong and mainland China to better manage EoL mobile phones in the future. Copyright © 2017 Elsevier Ltd. All rights reserved.

77 FR 27740 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... storage media''. Retrievability: Delete ``and Social Security Number''. Safeguards: Delete last sentence...: * * * * * Categories of individuals covered by the system: Delete entry and replace with ``Children and their sponsors... admission to, DLA-managed day care facilities.'' Categories of records in the system: Delete ``Social...

SANDO syndrome in a cohort of 107 patients with CPEO and mitochondrial DNA deletions.

PubMed

Hanisch, Frank; Kornhuber, Malte; Alston, Charlotte L; Taylor, Robert W; Deschauer, Marcus; Zierz, Stephan

2015-06-01

The sensory ataxic neuropathy with dysarthria and ophthalmoparesis (SANDO) syndrome is a subgroup of mitochondrial chronic progressive external ophthalmoplegia (CPEO)-plus disorders associated with multiple mitochondrial DNA (mtDNA) deletions. There is no systematic survey on SANDO in patients with CPEO with either single or multiple large-scale mtDNA deletions. In this retrospective analysis, we characterised the frequency, the genetic and clinical phenotype of 107 index patients with mitochondrial CPEO (n=66 patients with single and n=41 patients with multiple mtDNA deletions) and assessed these for clinical evidence of a SANDO phenotype. Patients with multiple mtDNA deletions were additionally screened for mutations in the nuclear-encoded POLG, SLC25A4, PEO1 and RRM2B genes. The clinical, histological and genetic data of 11 patients with SANDO were further analysed. None of the 66 patients with single, large-scale mtDNA deletions fulfilled the clinical criteria of SANDO syndrome. In contrast, 9 of 41 patients (22%) with multiple mtDNA deletions and two additional family members fulfilled the clinical criteria for SANDO. Within this subgroup, multiple mtDNA deletions were associated with the following nuclear mutations: POLG (n=6), PEO1 (n=2), unidentified (n=2). The combination of sensory ataxic neuropathy with ophthalmoparesis (SANO) was observed in 70% of patients with multiple mtDNA deletions but only in 4% with single deletions. The combination of CPEO and sensory ataxic neuropathy (SANO, incomplete SANDO) was found in 43% of patients with multiple mtDNA deletions but not in patients with single deletions. The SANDO syndrome seems to indicate a cluster of symptoms within the wide range of multisystemic symptoms associated with mitochondrial CPEO. SANO seems to be the most frequent phenotype associated with multiple mtDNA deletions in our cohort but not or is rarely associated with single, large-scale mtDNA deletions. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Behavioral differences among subjects with Prader-Willi syndrome and type I or type II deletion and maternal disomy.

PubMed

Butler, Merlin G; Bittel, Douglas C; Kibiryeva, Nataliya; Talebizadeh, Zohreh; Thompson, Travis

2004-03-01

To determine whether phenotypic differences exist among individuals with Prader-Willi syndrome with either type I or type II deletions of chromosome 15 or maternal disomy 15 leading to a better understanding of cause and pathophysiology of this classical genetic syndrome. We analyzed clinical, anthropometric, and behavioral data in 12 individuals (5 men, 7 women; mean age: 25.9 +/- 8.8 years) with PWS and a type I (TI) deletion, 14 individuals (6 men, 8 women; mean age: 19.6 +/- 6.5 years) with PWS and a type II (TII) deletion, and 21 individuals (10 men, 11 women; mean age: 23.6 +/- 9.2 years) with PWS and maternal disomy 15 (UPD). The deletion type was determined by genotyping of DNA markers between proximal chromosome 15 breakpoints BP1 and BP2. TI deletions are approximately 500 kb larger than TII deletions. Several validated psychological and behavioral tests were used to assess phenotypic characteristics of individuals with PWS representing the 3 genetic subtypes. Significant differences were found between the 2 deletion groups and those with UPD in multiple psychological and behavioral tests, but no differences were observed in other clinical or anthropometric data studied. Adaptive behavior scores were generally worse in individuals with PWS and the TI deletion, and specific obsessive-compulsive behaviors were more evident in the TI individuals compared with those with UPD. Individuals with PWS with TI deletions also had poorer reading and math skills as well as visual-motor integration. Our study indicates that individuals with TI deletion generally have more behavioral and psychological problems than individuals with the TII deletion or UPD. Four recently identified genes have been identified in the chromosome region between BP1 and BP2 with 1 of the genes (NIPA-1) expressed in mouse brain tissue but not thought to be imprinted. It may be important for brain development or function. These genes are deleted in individuals with TI deletion and are implicated in compulsive behavior and lower intellectual ability in individuals with TI versus TII.

11q deletion in neuroblastoma: a review of biological and clinical implications.

PubMed

Mlakar, Vid; Jurkovic Mlakar, Simona; Lopez, Gonzalo; Maris, John M; Ansari, Marc; Gumy-Pause, Fabienne

2017-06-29

Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is associated with higher disease stage and decreased survival probability. During the last 25 years, extensive efforts have been invested to identify the precise frequency of 11q aberrations in neuroblastoma, the recurrently involved genes, and to understand the molecular mechanisms of 11q deletion, but definitive answers are still unclear. In this review, it is our intent to compile and review the evidence acquired to date on 11q deletion in neuroblastoma.

Salivary IgG subclasses in individuals with and without homozygous IGHG gene deletions.

PubMed Central

Engström, P E; Norhagen, G; Osipova, L; Helal, A; Wiebe, V; Brusco, A; Carbonara, A O; Lefranc, G; Lefranc, M P

1996-01-01

In this study, the levels of salivary IgG1, IgG2, IgG3 and IgG4 from individuals with and without homozygous immunoglobulin heavy chain constant gene deletions were quantified by enzyme-linked immunosorbent assay (ELISA). To analyse the restriction of salivary IgG subclasses, we used unstimulated whole saliva and sera collected at the same time from individuals with homozygous gene deletions, two with G1 deletion, one with G4 deletion, six with both G2 and G4 deletions and from eight individuals without IGHG gene deletions and expressing all four IgG subclasses. The median values of salivary IgG from individuals with homozygous G1, or G4, or both G2 and G4 deletions, and from individuals expressing all four subclasses were 24.2 mg/l and 23.4 mg/l, respectively. The median values of serum IgG were 13.7 g/l and 15.9 g/l, respectively. Our results show that the salivary and serum IgG levels were both within the normal range in individuals with homozygous gene deletions of either G1, or G4, or both G2 and G4. PMID:8943711

Deletion detection for diagnosis of Duchenne muscular dystrophy in the Japanese population--comparison between the polymerase chain reaction and the Southern blot analysis.

PubMed

Katayama, S; Takeshita, N; Yano, T; Ubagai, T; Qiu, X J; Katagiri, Y; Kubo, H; Hirakawa, S

1993-06-01

We compared the efficacy of the multiplex PCR with that of the cDNA analysis for detection of deletions of the DMD gene in the Japanese patients. Thirty males with DMD from 27 Japanese families were studied by the multiplex PCR, and 24 of them were also investigated by Southern blot analysis. We used five dystrophin cDNA probes for deletion analysis. A total of 19 regions were amplified by the PCR to detect deletions, 9 regions by the method of Chamberlain et al. and another 10 regions by the method of Beggs et al. Deletions were detected in 14 (52%) out of 27 DMD families by the PCR. Southern blot analysis detected deletions in 14 (64%) out of 22 families. Thirteen (93%) of the 14 DMD families with deletions detected by Southern blotting were also confirmed by the multiplex PCR. Provided care is taken in cases where the deletion is limited to a single exon, the multiplex PCR appears to be an efficient and useful alternative to conventional Southern blot analysis for detecting deletions during the prenatal and postnatal diagnosis of DMD.

Prenatal Diagnosis and Molecular Analysis of a Large Novel Deletion (- -JS) Causing α0-Thalassemia.

PubMed

Cao, Jinru; He, Shuzhen; Pu, Yudong; Liu, Jingjing; Liu, Fuping; Feng, Jun

α-Thalassemia (α-thal) is a very common single gene hereditary disease caused by large deletions or point mutations of the α-globin gene cluster in tropical and subtropical regions of the world. Here, we report for the first time, a novel large α-thal deletion in a Chinese family from Jiangsu Province, People's Republic of China (PRC), which removes almost the entire α2 and α1 genes from the α-globin gene cluster. Thus, it was named the Jiangsu deletion (- - JS ) on the α-globin gene cluster causing α 0 -thal. Heterozygotes for this deletion showed an α-thal trait phenotype with reduced mean corpuscular volume (MCV) and mean corpuscular hemoglobin (Hb) (MCH) levels. The sequencing results showed that a 2538 bp deletion (NG_000006.1: g.35801_38338) existed in this novel genotype on the basis of -α 4.2 (leftward), indicating a deletion of about 6.8 kb from the α-globin cluster. In addition, a 29 bp sequence was inserted into the deletion during the recombination events that led to this deletion. Through pedigree analysis, we knew that the proband inherited the novel allele from his mother.

Positive selection of mutants with deletions of the gal-chl region of the Salmonella chromosome as a screening procedure for mutagens that cause deletions.

PubMed Central

Alper, M D; Ames, B N

1975-01-01

We have developed a convenient and specific positive selection for long deletions through the gal region of the chromosomes of Salmonella typhimurium and Escherichia coli. Through simultaneous selection for mutations in the two closely linked genes, gal and chlA, a variety of deletions of varying length, some extending through as much as 1 min of the chromosome, could be readily obtained. Many of these deletions resulted in the loss of a gene, which we named dhb, concerned with the ability of the bacterium to synthesize the iron chelating agent enterobactin. The selection was adapted for the screening of mutagens for their ability to generate long deletions in the bacterial deoxyribonucleic acid. Forty agents were screened for this capability. Nitrous acid, previously reported to be an efficient mutagen for this purpose, increased the frequency of deletion mutations 50-fold in our system. Three others, nitrogen mustard, mitomycin C, and fast neutrons, were shown to increase the frequency of long deletions between five- and eightfold. The remainder were found to be incapable of generating these deletions. PMID:1090571

Cancer genes mutation profiling in calcifying epithelial odontogenic tumour.

PubMed

de Sousa, Sílvia Ferreira; Diniz, Marina Gonçalves; França, Josiane Alves; Fontes Pereira, Thaís Dos Santos; Moreira, Rennan Garcias; Santos, Jean Nunes Dos; Gomez, Ricardo Santiago; Gomes, Carolina Cavalieri

2018-03-01

To identify calcifying epithelial odontogenic tumour (CEOT) mutations in oncogenes and tumour suppressor genes. A panel of 50 genes commonly mutated in cancer was sequenced in CEOT by next-generation sequencing. Sanger sequencing was used to cover the region of the frameshift deletion identified in one sample. Missense single nucleotide variants (SNVs) with minor allele frequency (MAF) <1% were detected in PTEN , MET and JAK3 . A frameshift deletion in CDKN2A occurred in association with a missense mutation in the same gene region, suggesting a second hit in the inactivation of this gene. APC, KDR, KIT, PIK3CA and TP53 missense SNVs were identified; however, these are common SNVs, showing MAF >1%. CEOT harbours mutations in the tumour suppressor PTEN and CDKN2A and in the oncogenes JAK3 and MET . As these mutations occurred in only one case each, they are probably not driver mutations for these tumours. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

A short note on dynamic programming in a band.

PubMed

Gibrat, Jean-François

2018-06-15

Third generation sequencing technologies generate long reads that exhibit high error rates, in particular for insertions and deletions which are usually the most difficult errors to cope with. The only exact algorithm capable of aligning sequences with insertions and deletions is a dynamic programming algorithm. In this note, for the sake of efficiency, we consider dynamic programming in a band. We show how to choose the band width in function of the long reads' error rates, thus obtaining an [Formula: see text] algorithm in space and time. We also propose a procedure to decide whether this algorithm, when applied to semi-global alignments, provides the optimal score. We suggest that dynamic programming in a band is well suited to the problem of aligning long reads between themselves and can be used as a core component of methods for obtaining a consensus sequence from the long reads alone. The function implementing the dynamic programming algorithm in a band is available, as a standalone program, at: https://forgemia.inra.fr/jean-francois.gibrat/BAND_DYN_PROG.git.

The surface protease ompT serves as Escherichia coli K1 adhesin in binding to human brain micro vascular endothelial cells.

PubMed

Wan, Lei; Guo, Yan; Hui, Chang-Ye; Liu, Xiao-Lu; Zhang, Wen-Bing; Cao, Hong; Cao, Hong

2014-05-01

Escherichia coli (E. coli) K1 is the most common bacteria that cause meningitis in the neonatal period. But it's not entirely clear about how E. coli crosses the blood-brain barrier. The features of the ompT deletion in meningitic E. coli infection were texted in vitro. In comparison with the parent strain, the isogenic ompT deletion mutant was significantly less adhesive to human brain microvascular endothelial cells (HBMEC). The adhesion-deficient phenotype of the mutant was restored to the level of the wild-type by complementing with low-level OmpT expression plasmid. Interestingly, the adhesion was enhanced by point mutation at the OmpT proposed catalytic residue D85. Compared with the poor adhesive activity of bovine serum albumin-coated fluorescent beads, recombinant OmpT or catalytically inactive variant of OmpT-coated beads bound to HBMEC monolayer effectively. Our study suggests that OmpT is important for bacterial adhesion while entering into central nervous system, and the adhesion does not involve in the proteolytic activity of OmpT.

Molecular characterization of NRXN1 deletions from 19,263 clinical microarray cases identifies exons important for neurodevelopmental disease expression.

PubMed

Lowther, Chelsea; Speevak, Marsha; Armour, Christine M; Goh, Elaine S; Graham, Gail E; Li, Chumei; Zeesman, Susan; Nowaczyk, Malgorzata J M; Schultz, Lee-Anne; Morra, Antonella; Nicolson, Rob; Bikangaga, Peter; Samdup, Dawa; Zaazou, Mostafa; Boyd, Kerry; Jung, Jack H; Siu, Victoria; Rajguru, Manjulata; Goobie, Sharan; Tarnopolsky, Mark A; Prasad, Chitra; Dick, Paul T; Hussain, Asmaa S; Walinga, Margreet; Reijenga, Renske G; Gazzellone, Matthew; Lionel, Anath C; Marshall, Christian R; Scherer, Stephen W; Stavropoulos, Dimitri J; McCready, Elizabeth; Bassett, Anne S

2017-01-01

The purpose of the current study was to assess the penetrance of NRXN1 deletions. We compared the prevalence and genomic extent of NRXN1 deletions identified among 19,263 clinically referred cases to that of 15,264 controls. The burden of additional clinically relevant copy-number variations (CNVs) was used as a proxy to estimate the relative penetrance of NRXN1 deletions. We identified 41 (0.21%) previously unreported exonic NRXN1 deletions ascertained for developmental delay/intellectual disability that were significantly greater than in controls (odds ratio (OR) = 8.14; 95% confidence interval (CI): 2.91-22.72; P < 0.0001). Ten (22.7%) of these had a second clinically relevant CNV. Subjects with a deletion near the 3' end of NRXN1 were significantly more likely to have a second rare CNV than subjects with a 5' NRXN1 deletion (OR = 7.47; 95% CI: 2.36-23.61; P = 0.0006). The prevalence of intronic NRXN1 deletions was not statistically different between cases and controls (P = 0.618). The majority (63.2%) of intronic NRXN1 deletion cases had a second rare CNV at a prevalence twice as high as that for exonic NRXN1 deletion cases (P = 0.0035). The results support the importance of exons near the 5' end of NRXN1 in the expression of neurodevelopmental disorders. Intronic NRXN1 deletions do not appear to substantially increase the risk for clinical phenotypes.Genet Med 19 1, 53-61.

Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arpino, James A. J.; Rizkallah, Pierre J., E-mail: rizkallahp@cardiff.ac.uk; Jones, D. Dafydd, E-mail: rizkallahp@cardiff.ac.uk

2014-08-01

The beneficial engineered single-amino-acid deletion variants EGFP{sup D190Δ} and EGFP{sup A227Δ} have been studied. Single-amino-acid deletions are a common part of the natural evolutionary landscape but are rarely sampled during protein engineering owing to limited and prejudiced molecular understanding of mutations that shorten the protein backbone. Single-amino-acid deletion variants of enhanced green fluorescent protein (EGFP) have been identified by directed evolution with the beneficial effect of imparting increased cellular fluorescence. Biophysical characterization revealed that increased functional protein production and not changes to the fluorescence parameters was the mechanism that was likely to be responsible. The structure EGFP{sup D190Δ} containing amore » deletion within a loop revealed propagated changes only after the deleted residue. The structure of EGFP{sup A227Δ} revealed that a ‘flipping’ mechanism was used to adjust for residue deletion at the end of a β-strand, with amino acids C-terminal to the deletion site repositioning to take the place of the deleted amino acid. In both variants new networks of short-range and long-range interactions are generated while maintaining the integrity of the hydrophobic core. Both deletion variants also displayed significant local and long-range changes in dynamics, as evident by changes in B factors compared with EGFP. Rather than being detrimental, deletion mutations can introduce beneficial structural effects through altering core protein properties, folding and dynamics, as well as function.« less

48 CFR 1845.7101-4 - Types of deletions from contractor property records.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Types of deletions from contractor property records. Contractors shall report the types of deletions... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Types of deletions from contractor property records. 1845.7101-4 Section 1845.7101-4 Federal Acquisition Regulations System NATIONAL...

48 CFR 1845.7101-4 - Types of deletions from contractor property records.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Types of deletions from contractor property records. Contractors shall report the types of deletions... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Types of deletions from contractor property records. 1845.7101-4 Section 1845.7101-4 Federal Acquisition Regulations System NATIONAL...

48 CFR 1845.7101-4 - Types of deletions from contractor property records.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Types of deletions from contractor property records. Contractors shall report the types of deletions... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Types of deletions from contractor property records. 1845.7101-4 Section 1845.7101-4 Federal Acquisition Regulations System NATIONAL...

48 CFR 1845.7101-4 - Types of deletions from contractor property records.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Types of deletions from contractor property records. Contractors shall report the types of deletions... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Types of deletions from contractor property records. 1845.7101-4 Section 1845.7101-4 Federal Acquisition Regulations System NATIONAL...

48 CFR 1845.7101-4 - Types of deletions from contractor property records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Types of deletions from contractor property records. Contractors shall report the types of deletions... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Types of deletions from contractor property records. 1845.7101-4 Section 1845.7101-4 Federal Acquisition Regulations System NATIONAL...

76 FR 35859 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-20

... deleting and shredding paper copies. Registers are destroyed by electronic deletion 40 years after the date... electronically deleting and shredding paper copies. Registers are destroyed by electronic deletion 40 years after...) is used to authenticate and lock out unauthorized access. Paper records are maintained in locked file...

An Extension to the Multilevel Logic Simulator for Microcomputers.

DTIC Science & Technology

1987-06-01

gates .............................. 61 3. Add or delete inputs ............................... 61 4. Add or delete outputs...the gates affected by the deletion. 61 4. Add or delete outputs The only modification that will be done in the circuit is the insertion (deletion) of...recompilation of the circuit. P 105 -Z -- % % 9,m "N , " " " " " ’ ’-"" " " " " " " " - -" , " " -- -" - .’ TABLE 25 THE DELINP CASE FOR THE ALU CIRCUIT JI

Revisiting Huey: on the importance of the upper part of words during reading.

PubMed

Perea, Manuel

2012-12-01

Recent research has shown that that the upper part of words enjoys an advantage over the lower part of words in the recognition of isolated words. The goal of the present article was to examine how removing the upper/lower part of the words influences eye movement control during silent normal reading. The participants' eye movements were monitored when reading intact sentences and when reading sentences in which the upper or the lower portion of the text was deleted. Results showed a greater reading cost (longer fixations) when the upper part of the text was removed than when the lower part of the text was removed (i.e., it influenced when to move the eyes). However, there was little influence on the initial landing position on a target word (i.e., on the decision as to where to move the eyes). In addition, lexical-processing difficulty (as inferred from the magnitude of the word frequency effect on a target word) was affected by text degradation. The implications of these findings for models of visual-word recognition and reading are discussed.

Neurological presentation of three patients with 22q11 deletion (CATCH 22 syndrome).

PubMed

Roubertie, A; Semprino, M; Chaze, A M; Rivier, F; Humbertclaude, V; Cheminal, R; Lefort, G; Echenne, B

2001-12-01

Chromosome 22q11 deletion (CATCH 22 syndrome or velocardiofacial syndrome) is one of the most frequent chromosomal syndromes. Neurological features other than cognitive disorders are probably the least-described part of the expanding phenotype of the 22q11 deletion. We report the neurological features of three unrelated children with a de novo deletion: one patient with an autistic disorder, a second patient with hypocalcaemic neonatal seizures and unusual persistent epileptic focus at electroencephalographic follow-up, and a third patient with atypical absence epilepsy. These observations enlarge the clinical and neurological spectrum of the 22q11 deletion. Awareness of such cases is necessary, and a diagnosis of the 22q11 deletion should be suspected in children with common neurological features associated with severe or mild dysmorphism. Diagnosis of the 22q11 deletion should be confirmed by fluorescence in situ hybridization analysis associated with standard chromosomal analysis.