Science.gov

Sample records for demand response opportunities

  1. Automated Demand Response Opportunities in Wastewater Treatment Facilities

    SciTech Connect

    Thompson, Lisa; Song, Katherine; Lekov, Alex; McKane, Aimee

    2008-11-19

    Wastewater treatment is an energy intensive process which, together with water treatment, comprises about three percent of U.S. annual energy use. Yet, since wastewater treatment facilities are often peripheral to major electricity-using industries, they are frequently an overlooked area for automated demand response opportunities. Demand response is a set of actions taken to reduce electric loads when contingencies, such as emergencies or congestion, occur that threaten supply-demand balance, and/or market conditions occur that raise electric supply costs. Demand response programs are designed to improve the reliability of the electric grid and to lower the use of electricity during peak times to reduce the total system costs. Open automated demand response is a set of continuous, open communication signals and systems provided over the Internet to allow facilities to automate their demand response activities without the need for manual actions. Automated demand response strategies can be implemented as an enhanced use of upgraded equipment and facility control strategies installed as energy efficiency measures. Conversely, installation of controls to support automated demand response may result in improved energy efficiency through real-time access to operational data. This paper argues that the implementation of energy efficiency opportunities in wastewater treatment facilities creates a base for achieving successful demand reductions. This paper characterizes energy use and the state of demand response readiness in wastewater treatment facilities and outlines automated demand response opportunities.

  2. Opportunities for Automated Demand Response in California Wastewater Treatment Facilities

    SciTech Connect

    Aghajanzadeh, Arian; Wray, Craig; McKane, Aimee

    2015-08-30

    Previous research over a period of six years has identified wastewater treatment facilities as good candidates for demand response (DR), automated demand response (Auto-­DR), and Energy Efficiency (EE) measures. This report summarizes that work, including the characteristics of wastewater treatment facilities, the nature of the wastewater stream, energy used and demand, as well as details of the wastewater treatment process. It also discusses control systems and automated demand response opportunities. Furthermore, this report summarizes the DR potential of three wastewater treatment facilities. In particular, Lawrence Berkeley National Laboratory (LBNL) has collected data at these facilities from control systems, submetered process equipment, utility electricity demand records, and governmental weather stations. The collected data were then used to generate a summary of wastewater power demand, factors affecting that demand, and demand response capabilities. These case studies show that facilities that have implemented energy efficiency measures and that have centralized control systems are well suited to shed or shift electrical loads in response to financial incentives, utility bill savings, and/or opportunities to enhance reliability of service. In summary, municipal wastewater treatment energy demand in California is large, and energy-­intensive equipment offers significant potential for automated demand response. In particular, large load reductions were achieved by targeting effluent pumps and centrifuges. One of the limiting factors to implementing demand response is the reaction of effluent turbidity to reduced aeration at an earlier stage of the process. Another limiting factor is that cogeneration capabilities of municipal facilities, including existing power purchase agreements and utility receptiveness to purchasing electricity from cogeneration facilities, limit a facility’s potential to participate in other DR activities.

  3. Demand Response and Open Automated Demand Response Opportunities for Data Centers

    SciTech Connect

    Ghatikar, Girish; Piette, Mary Ann; Fujita, Sydny; McKane, Aimee; Dudley, Junqiao Han; Radspieler, Anthony; Mares, K.C.; Shroyer, Dave

    2009-12-30

    This study examines data center characteristics, loads, control systems, and technologies to identify demand response (DR) and automated DR (Open Auto-DR) opportunities and challenges. The study was performed in collaboration with technology experts, industrial partners, and data center facility managers and existing research on commercial and industrial DR was collected and analyzed. The results suggest that data centers, with significant and rapidly growing energy use, have significant DR potential. Because data centers are highly automated, they are excellent candidates for Open Auto-DR. 'Non-mission-critical' data centers are the most likely candidates for early adoption of DR. Data center site infrastructure DR strategies have been well studied for other commercial buildings; however, DR strategies for information technology (IT) infrastructure have not been studied extensively. The largest opportunity for DR or load reduction in data centers is in the use of virtualization to reduce IT equipment energy use, which correspondingly reduces facility cooling loads. DR strategies could also be deployed for data center lighting, and heating, ventilation, and air conditioning. Additional studies and demonstrations are needed to quantify benefits to data centers of participating in DR and to address concerns about DR's possible impact on data center performance or quality of service and equipment life span.

  4. Opportunities for Automated Demand Response in California Agricultural Irrigation

    SciTech Connect

    Olsen, Daniel; Aghajanzadeh, Arian; McKane, Aimee

    2015-08-01

    Pumping water for agricultural irrigation represents a significant share of California’s annual electricity use and peak demand. It also represents a large source of potential flexibility, as farms possess a form of storage in their wetted soil. By carefully modifying their irrigation schedules, growers can participate in demand response without adverse effects on their crops. This report describes the potential for participation in demand response and automated demand response by agricultural irrigators in California, as well as barriers to widespread participation. The report first describes the magnitude, timing, location, purpose, and manner of energy use in California. Typical on-­farm controls are discussed, as well as common impediments to participation in demand response and automated demand response programs. Case studies of demand response programs in California and across the country are reviewed, and their results along with overall California demand estimates are used to estimate statewide demand response potential. Finally, recommendations are made for future research that can enhance the understanding of demand response potential in this industry.

  5. Opportunities, Barriers and Actions for Industrial Demand Response in California

    SciTech Connect

    McKane, Aimee T.; Piette, Mary Ann; Faulkner, David; Ghatikar, Girish; Radspieler Jr., Anthony; Adesola, Bunmi; Murtishaw, Scott; Kiliccote, Sila

    2008-01-31

    In 2006 the Demand Response Research Center (DRRC) formed an Industrial Demand Response Team to investigate opportunities and barriers to implementation of Automated Demand Response (Auto-DR) systems in California industries. Auto-DR is an open, interoperable communications and technology platform designed to: Provide customers with automated, electronic price and reliability signals; Provide customers with capability to automate customized DR strategies; Automate DR, providing utilities with dispatchable operational capability similar to conventional generation resources. This research began with a review of previous Auto-DR research on the commercial sector. Implementing Auto-DR in industry presents a number of challenges, both practical and perceived. Some of these include: the variation in loads and processes across and within sectors, resource-dependent loading patterns that are driven by outside factors such as customer orders or time-critical processing (e.g. tomato canning), the perceived lack of control inherent in the term 'Auto-DR', and aversion to risk, especially unscheduled downtime. While industry has demonstrated a willingness to temporarily provide large sheds and shifts to maintain grid reliability and be a good corporate citizen, the drivers for widespread Auto-DR will likely differ. Ultimately, most industrial facilities will balance the real and perceived risks associated with Auto-DR against the potential for economic gain through favorable pricing or incentives. Auto-DR, as with any ongoing industrial activity, will need to function effectively within market structures. The goal of the industrial research is to facilitate deployment of industrial Auto-DR that is economically attractive and technologically feasible. Automation will make DR: More visible by providing greater transparency through two-way end-to-end communication of DR signals from end-use customers; More repeatable, reliable, and persistent because the automated controls

  6. Demand Response Opportunities in Industrial Refrigerated Warehouses in California

    SciTech Connect

    Goli, Sasank; McKane, Aimee; Olsen, Daniel

    2011-06-14

    Industrial refrigerated warehouses that implemented energy efficiency measures and have centralized control systems can be excellent candidates for Automated Demand Response (Auto-DR) due to equipment synergies, and receptivity of facility managers to strategies that control energy costs without disrupting facility operations. Auto-DR utilizes OpenADR protocol for continuous and open communication signals over internet, allowing facilities to automate their Demand Response (DR). Refrigerated warehouses were selected for research because: They have significant power demand especially during utility peak periods; most processes are not sensitive to short-term (2-4 hours) lower power and DR activities are often not disruptive to facility operations; the number of processes is limited and well understood; and past experience with some DR strategies successful in commercial buildings may apply to refrigerated warehouses. This paper presents an overview of the potential for load sheds and shifts from baseline electricity use in response to DR events, along with physical configurations and operating characteristics of refrigerated warehouses. Analysis of data from two case studies and nine facilities in Pacific Gas and Electric territory, confirmed the DR abilities inherent to refrigerated warehouses but showed significant variation across facilities. Further, while load from California's refrigerated warehouses in 2008 was 360 MW with estimated DR potential of 45-90 MW, actual achieved was much less due to low participation. Efforts to overcome barriers to increased participation may include, improved marketing and recruitment of potential DR sites, better alignment and emphasis on financial benefits of participation, and use of Auto-DR to increase consistency of participation.

  7. Opportunities for Energy Efficiency and Automated Demand Response in Industrial Refrigerated Warehouses in California

    SciTech Connect

    Lekov, Alex; Thompson, Lisa; McKane, Aimee; Rockoff, Alexandra; Piette, Mary Ann

    2009-05-11

    This report summarizes the Lawrence Berkeley National Laboratory's research to date in characterizing energy efficiency and open automated demand response opportunities for industrial refrigerated warehouses in California. The report describes refrigerated warehouses characteristics, energy use and demand, and control systems. It also discusses energy efficiency and open automated demand response opportunities and provides analysis results from three demand response studies. In addition, several energy efficiency, load management, and demand response case studies are provided for refrigerated warehouses. This study shows that refrigerated warehouses can be excellent candidates for open automated demand response and that facilities which have implemented energy efficiency measures and have centralized control systems are well-suited to shift or shed electrical loads in response to financial incentives, utility bill savings, and/or opportunities to enhance reliability of service. Control technologies installed for energy efficiency and load management purposes can often be adapted for open automated demand response (OpenADR) at little additional cost. These improved controls may prepare facilities to be more receptive to OpenADR due to both increased confidence in the opportunities for controlling energy cost/use and access to the real-time data.

  8. Opportunities for Demand Response in California Agricultural Irrigation: A Scoping Study

    SciTech Connect

    Marks, Gary; Wilcox, Edmund; Olsen, Daniel; Goli, Sasank

    2013-01-02

    California agricultural irrigation consumes more than ten billion kilowatt hours of electricity annually and has significant potential for contributing to a reduction of stress on the grid through demand response, permanent load shifting, and energy efficiency measures. To understand this potential, a scoping study was initiated for the purpose of determining the associated opportunities, potential, and adoption challenges in California agricultural irrigation. The primary research for this study was conducted in two ways. First, data was gathered and parsed from published sources that shed light on where the best opportunities for load shifting and demand response lie within the agricultural irrigation sector. Secondly, a small limited survey was conducted as informal face-to-face interviews with several different California growers to get an idea of their ability and willingness to participate in permanent load shifting and/or demand response programs. Analysis of the data obtained from published sources and the survey reveal demand response and permanent load shifting opportunities by growing region, irrigation source, irrigation method, grower size, and utility coverage. The study examines some solutions for demand response and permanent load shifting in agricultural irrigation, which include adequate irrigation system capacity, automatic controls, variable frequency drives, and the contribution from energy efficiency measures. The study further examines the potential and challenges for grower acceptance of demand response and permanent load shifting in California agricultural irrigation. As part of the examination, the study considers to what extent permanent load shifting, which is already somewhat accepted within the agricultural sector, mitigates the need or benefit of demand response for agricultural irrigation. Recommendations for further study include studies on how to gain grower acceptance of demand response as well as other related studies such as

  9. Opportunities for Automated Demand Response in California’s Dairy Processing Industry

    SciTech Connect

    Homan, Gregory K.; Aghajanzadeh, Arian; McKane, Aimee

    2015-08-30

    During periods of peak electrical demand on the energy grid or when there is a shortage of supply, the stability of the grid may be compromised or the cost of supplying electricity may rise dramatically, respectively. Demand response programs are designed to mitigate the severity of these problems and improve reliability by reducing the demand on the grid during such critical times. In 2010, the Demand Response Research Center convened a group of industry experts to suggest potential industries that would be good demand response program candidates for further review. The dairy industry was suggested due to the perception that the industry had suitable flexibility and automatic controls in place. The purpose of this report is to provide an initial description of the industry with regard to demand response potential, specifically automated demand response. This report qualitatively describes the potential for participation in demand response and automated demand response by dairy processing facilities in California, as well as barriers to widespread participation. The report first describes the magnitude, timing, location, purpose, and manner of energy use. Typical process equipment and controls are discussed, as well as common impediments to participation in demand response and automated demand response programs. Two case studies of demand response at dairy facilities in California and across the country are reviewed. Finally, recommendations are made for future research that can enhance the understanding of demand response potential in this industry.

  10. Opportunities for Energy Efficiency and Demand Response in the California Cement Industry

    SciTech Connect

    Olsen, Daniel; Goli, Sasank; Faulkner, David; McKane, Aimee

    2010-12-22

    This study examines the characteristics of cement plants and their ability to shed or shift load to participate in demand response (DR). Relevant factors investigated include the various equipment and processes used to make cement, the operational limitations cement plants are subject to, and the quantities and sources of energy used in the cement-making process. Opportunities for energy efficiency improvements are also reviewed. The results suggest that cement plants are good candidates for DR participation. The cement industry consumes over 400 trillion Btu of energy annually in the United States, and consumes over 150 MW of electricity in California alone. The chemical reactions required to make cement occur only in the cement kiln, and intermediate products are routinely stored between processing stages without negative effects. Cement plants also operate continuously for months at a time between shutdowns, allowing flexibility in operational scheduling. In addition, several examples of cement plants altering their electricity consumption based on utility incentives are discussed. Further study is needed to determine the practical potential for automated demand response (Auto-DR) and to investigate the magnitude and shape of achievable sheds and shifts.

  11. Opportunities for Energy Efficiency and Open Automated Demand Response in Wastewater Treatment Facilities in California -- Phase I Report

    SciTech Connect

    Lekov, Alex; Thompson, Lisa; McKane, Aimee; Song, Katherine; Piette, Mary Ann

    2009-04-01

    This report summarizes the Lawrence Berkeley National Laboratory?s research to date in characterizing energy efficiency and automated demand response opportunities for wastewater treatment facilities in California. The report describes the characteristics of wastewater treatment facilities, the nature of the wastewater stream, energy use and demand, as well as details of the wastewater treatment process. It also discusses control systems and energy efficiency and automated demand response opportunities. In addition, several energy efficiency and load management case studies are provided for wastewater treatment facilities.This study shows that wastewater treatment facilities can be excellent candidates for open automated demand response and that facilities which have implemented energy efficiency measures and have centralized control systems are well-suited to shift or shed electrical loads in response to financial incentives, utility bill savings, and/or opportunities to enhance reliability of service. Control technologies installed for energy efficiency and load management purposes can often be adapted for automated demand response at little additional cost. These improved controls may prepare facilities to be more receptive to open automated demand response due to both increased confidence in the opportunities for controlling energy cost/use and access to the real-time data.

  12. Opportunities for Automated Demand Response in Wastewater Treatment Facilities in California - Southeast Water Pollution Control Plant Case Study

    SciTech Connect

    Olsen, Daniel; Goli, Sasank; Faulkner, David; McKane, Aimee

    2012-12-20

    This report details a study into the demand response potential of a large wastewater treatment facility in San Francisco. Previous research had identified wastewater treatment facilities as good candidates for demand response and automated demand response, and this study was conducted to investigate facility attributes that are conducive to demand response or which hinder its implementation. One years' worth of operational data were collected from the facility's control system, submetered process equipment, utility electricity demand records, and governmental weather stations. These data were analyzed to determine factors which affected facility power demand and demand response capabilities The average baseline demand at the Southeast facility was approximately 4 MW. During the rainy season (October-March) the facility treated 40% more wastewater than the dry season, but demand only increased by 4%. Submetering of the facility's lift pumps and centrifuges predicted load shifts capabilities of 154 kW and 86 kW, respectively, with large lift pump shifts in the rainy season. Analysis of demand data during maintenance events confirmed the magnitude of these possible load shifts, and indicated other areas of the facility with demand response potential. Load sheds were seen to be possible by shutting down a portion of the facility's aeration trains (average shed of 132 kW). Load shifts were seen to be possible by shifting operation of centrifuges, the gravity belt thickener, lift pumps, and external pump stations These load shifts were made possible by the storage capabilities of the facility and of the city's sewer system. Large load reductions (an average of 2,065 kW) were seen from operating the cogeneration unit, but normal practice is continuous operation, precluding its use for demand response. The study also identified potential demand response opportunities that warrant further study: modulating variable-demand aeration loads, shifting operation of sludge

  13. Demand Response Quick Assessment Tool

    2008-12-01

    DRQAT (Demand Response Quick Assessment Tool) is the tool for assessing demand response saving potentials for large commercial buildings. This tool is based on EnergyPlus simulations of prototypical buildings and HVAC equipment. The opportunities for demand reduction and cost savings with building demand responsive controls vary tremendously with building type and location. The assessment tools will predict the energy and demand savings, the economic savings, and the thermal comfor impact for various demand responsive strategies.more » Users of the tools will be asked to enter the basic building information such as types, square footage, building envelope, orientation, utility schedule, etc. The assessment tools will then use the prototypical simulation models to calculate the energy and demand reduction potential under certain demand responsive strategies, such as precooling, zonal temperature set up, and chilled water loop and air loop set points adjustment.« less

  14. The Integration of Energy Efficiency, Renewable Energy, DemandResponse and Climate Change: Challenges and Opportunities for Evaluatorsand Planners

    SciTech Connect

    Vine, Edward

    2007-05-29

    This paper explores the feasibility of integrating energyefficiency program evaluation with the emerging need for the evaluationof programs from different "energy cultures" (demand response, renewableenergy, and climate change). The paper reviews key features andinformation needs of the energy cultures and critically reviews theopportunities and challenges associated with integrating these withenergy efficiency program evaluation. There is a need to integrate thedifferent policy arenas where energy efficiency, demand response, andclimate change programs are developed, and there are positive signs thatthis integration is starting to occur.

  15. Demand Response Analysis Tool

    2012-03-01

    Demand Response Analysis Tool is a software developed at the Lawrence Berkeley National Laboratory. It is initially funded by Southern California Edison. Our goal in developing this tool is to provide an online, useable, with standardized methods, an analysis tool to evaluate demand and demand response performance of commercial and industrial facilities. The tool provides load variability and weather sensitivity analysis capabilities as well as development of various types of baselines. It can be usedmore » by researchers, real estate management firms, utilities, or any individuals who are interested in analyzing their demand and demand response capabilities.« less

  16. Opportunities for Open Automated Demand Response in Wastewater Treatment Facilities in California - Phase II Report. San Luis Rey Wastewater Treatment Plant Case Study

    SciTech Connect

    Thompson, Lisa; Lekov, Alex; McKane, Aimee; Piette, Mary Ann

    2010-08-20

    This case study enhances the understanding of open automated demand response opportunities in municipal wastewater treatment facilities. The report summarizes the findings of a 100 day submetering project at the San Luis Rey Wastewater Treatment Plant, a municipal wastewater treatment facility in Oceanside, California. The report reveals that key energy-intensive equipment such as pumps and centrifuges can be targeted for large load reductions. Demand response tests on the effluent pumps resulted a 300 kW load reduction and tests on centrifuges resulted in a 40 kW load reduction. Although tests on the facility?s blowers resulted in peak period load reductions of 78 kW sharp, short-lived increases in the turbidity of the wastewater effluent were experienced within 24 hours of the test. The results of these tests, which were conducted on blowers without variable speed drive capability, would not be acceptable and warrant further study. This study finds that wastewater treatment facilities have significant open automated demand response potential. However, limiting factors to implementing demand response are the reaction of effluent turbidity to reduced aeration load, along with the cogeneration capabilities of municipal facilities, including existing power purchase agreements and utility receptiveness to purchasing electricity from cogeneration facilities.

  17. Demand Response Dispatch Tool

    2012-08-31

    The Demand Response (DR) Dispatch Tool uses price profiles to dispatch demand response resources and create load modifying profiles. These annual profiles are used as inputs to production cost models and regional planning tools (e.g., PROMOD). The tool has been effectively implemented in transmission planning studies conducted by the Western Electricity Coordinating Council via its Transmission Expansion Planning and Policy Committee. The DR Dispatch Tool can properly model the dispatch of DR resources for bothmore » reliability and economic conditions.« less

  18. Dividends with Demand Response

    SciTech Connect

    Kintner-Meyer, Michael CW; Goldman, Charles; Sezgen, O.; Pratt, D.

    2003-10-31

    To assist facility managers in assessing whether and to what extent they should participate in demand response programs offered by ISOs, we introduce a systematic process by which a curtailment supply curve can be developed that integrates costs and other program provisions and features. This curtailment supply curve functions as bid curve, which allows the facility manager to incrementally offer load to the market under terms and conditions acceptable to the customer. We applied this load curtailment assessment process to a stylized example of an office building, using programs offered by NYISO to provide detail and realism.

  19. Automated Demand Response and Commissioning

    SciTech Connect

    Piette, Mary Ann; Watson, David S.; Motegi, Naoya; Bourassa, Norman

    2005-04-01

    This paper describes the results from the second season of research to develop and evaluate the performance of new Automated Demand Response (Auto-DR) hardware and software technology in large facilities. Demand Response (DR) is a set of activities to reduce or shift electricity use to improve the electric grid reliability and manage electricity costs. Fully-Automated Demand Response does not involve human intervention, but is initiated at a home, building, or facility through receipt of an external communications signal. We refer to this as Auto-DR. The evaluation of the control and communications must be properly configured and pass through a set of test stages: Readiness, Approval, Price Client/Price Server Communication, Internet Gateway/Internet Relay Communication, Control of Equipment, and DR Shed Effectiveness. New commissioning tests are needed for such systems to improve connecting demand responsive building systems to the electric grid demand response systems.

  20. Global Energy: Supply, Demand, Consequences, Opportunities

    SciTech Connect

    Majumdar, Arun

    2008-08-14

    July 29, 2008 Berkeley Lab lecture: Arun Majumdar, Director of the Environmental Energy Technologies Division, discusses current and future projections of economic growth, population, and global energy demand and supply, and explores the implications of these trends for the environment.

  1. Global Energy: Supply, Demand, Consequences, Opportunities

    ScienceCinema

    Majumdar, Arun

    2016-07-12

    July 29, 2008 Berkeley Lab lecture: Arun Majumdar, Director of the Environmental Energy Technologies Division, discusses current and future projections of economic growth, population, and global energy demand and supply, and explores the implications of these trends for the environment.

  2. Saving Electricity and Demand Response

    NASA Astrophysics Data System (ADS)

    Yamaguchi, Nobuyuki

    A lot of people lost their lives in the tremendous earthquake in Tohoku region on March 11. A large capacity of electric power plants in TEPCO area was also damaged and large scale power shortage in this summer is predicted. In this situation, electricity customers are making great effort to save electricity to avoid planned outage. Customers take actions not only by their selves but also by some customers' cooperative movements. All actions taken actually are based on responses to request form the government or voluntary decision. On the other hand, demand response based on a financial stimulus is not observed as an actual behavior. Saving electricity by this demand response only discussed in the newspapers. In this commentary, the events regarding electricity-saving measure after this disaster are described and the discussions on demand response, especially a raise in power rate, are put into shapes in the context of this electricity supply-demand gap.

  3. Demand Response Spinning Reserve Demonstration

    SciTech Connect

    Eto, Joseph H.; Nelson-Hoffman, Janine; Torres, Carlos; Hirth,Scott; Yinger, Bob; Kueck, John; Kirby, Brendan; Bernier, Clark; Wright,Roger; Barat, A.; Watson, David S.

    2007-05-01

    The Demand Response Spinning Reserve project is a pioneeringdemonstration of how existing utility load-management assets can providean important electricity system reliability resource known as spinningreserve. Using aggregated demand-side resources to provide spinningreserve will give grid operators at the California Independent SystemOperator (CAISO) and Southern California Edison (SCE) a powerful, newtool to improve system reliability, prevent rolling blackouts, and lowersystem operating costs.

  4. Refrigerated Warehouse Demand Response Strategy Guide

    SciTech Connect

    Scott, Doug; Castillo, Rafael; Larson, Kyle; Dobbs, Brian; Olsen, Daniel

    2015-11-01

    This guide summarizes demand response measures that can be implemented in refrigerated warehouses. In an appendix, it also addresses related energy efficiency opportunities. Reducing overall grid demand during peak periods and energy consumption has benefits for facility operators, grid operators, utility companies, and society. State wide demand response potential for the refrigerated warehouse sector in California is estimated to be over 22.1 Megawatts. Two categories of demand response strategies are described in this guide: load shifting and load shedding. Load shifting can be accomplished via pre-cooling, capacity limiting, and battery charger load management. Load shedding can be achieved by lighting reduction, demand defrost and defrost termination, infiltration reduction, and shutting down miscellaneous equipment. Estimation of the costs and benefits of demand response participation yields simple payback periods of 2-4 years. To improve demand response performance, it’s suggested to install air curtains and another form of infiltration barrier, such as a rollup door, for the passageways. Further modifications to increase efficiency of the refrigeration unit are also analyzed. A larger condenser can maintain the minimum saturated condensing temperature (SCT) for more hours of the day. Lowering the SCT reduces the compressor lift, which results in an overall increase in refrigeration system capacity and energy efficiency. Another way of saving energy in refrigerated warehouses is eliminating the use of under-floor resistance heaters. A more energy efficient alternative to resistance heaters is to utilize the heat that is being rejected from the condenser through a heat exchanger. These energy efficiency measures improve efficiency either by reducing the required electric energy input for the refrigeration system, by helping to curtail the refrigeration load on the system, or by reducing both the load and required energy input.

  5. Smart Buildings and Demand Response

    NASA Astrophysics Data System (ADS)

    Kiliccote, Sila; Piette, Mary Ann; Ghatikar, Girish

    2011-11-01

    Advances in communications and control technology, the strengthening of the Internet, and the growing appreciation of the urgency to reduce demand side energy use are motivating the development of improvements in both energy efficiency and demand response (DR) systems in buildings. This paper provides a framework linking continuous energy management and continuous communications for automated demand response (Auto-DR) in various times scales. We provide a set of concepts for monitoring and controls linked to standards and procedures such as Open Automation Demand Response Communication Standards (OpenADR). Basic building energy science and control issues in this approach begin with key building components, systems, end-uses and whole building energy performance metrics. The paper presents a framework about when energy is used, levels of services by energy using systems, granularity of control, and speed of telemetry. DR, when defined as a discrete event, requires a different set of building service levels than daily operations. We provide examples of lessons from DR case studies and links to energy efficiency.

  6. Demand Responsive Lighting: A Scoping Study

    SciTech Connect

    Rubinstein, Francis; Kiliccote, Sila

    2007-01-03

    The objective of this scoping study is: (1) to identify current market drivers and technology trends that can improve the demand responsiveness of commercial building lighting systems and (2) to quantify the energy, demand and environmental benefits of implementing lighting demand response and energy-saving controls strategies Statewide. Lighting systems in California commercial buildings consume 30 GWh. Lighting systems in commercial buildings often waste energy and unnecessarily stress the electrical grid because lighting controls, especially dimming, are not widely used. But dimmable lighting equipment, especially the dimming ballast, costs more than non-dimming lighting and is expensive to retrofit into existing buildings because of the cost of adding control wiring. Advances in lighting industry capabilities coupled with the pervasiveness of the Internet and wireless technologies have led to new opportunities to realize significant energy saving and reliable demand reduction using intelligent lighting controls. Manufacturers are starting to produce electronic equipment--lighting-application specific controllers (LAS controllers)--that are wirelessly accessible and can control dimmable or multilevel lighting systems obeying different industry-accepted protocols. Some companies make controllers that are inexpensive to install in existing buildings and allow the power consumed by bi-level lighting circuits to be selectively reduced during demand response curtailments. By intelligently limiting the demand from bi-level lighting in California commercial buildings, the utilities would now have an enormous 1 GW demand shed capability at hand. By adding occupancy and light sensors to the remotely controllable lighting circuits, automatic controls could harvest an additional 1 BkWh/yr savings above and beyond the savings that have already been achieved. The lighting industry's adoption of DALI as the principal wired digital control protocol for dimming ballasts and

  7. Demand Response Valuation Frameworks Paper

    SciTech Connect

    Heffner, Grayson

    2009-02-01

    While there is general agreement that demand response (DR) is a valued component in a utility resource plan, there is a lack of consensus regarding how to value DR. Establishing the value of DR is a prerequisite to determining how much and what types of DR should be implemented, to which customers DR should be targeted, and a key determinant that drives the development of economically viable DR consumer technology. Most approaches for quantifying the value of DR focus on changes in utility system revenue requirements based on resource plans with and without DR. This ''utility centric'' approach does not assign any value to DR impacts that lower energy and capacity prices, improve reliability, lower system and network operating costs, produce better air quality, and provide improved customer choice and control. Proper valuation of these benefits requires a different basis for monetization. The review concludes that no single methodology today adequately captures the wide range of benefits and value potentially attributed to DR. To provide a more comprehensive valuation approach, current methods such as the Standard Practice Method (SPM) will most likely have to be supplemented with one or more alternative benefit-valuation approaches. This report provides an updated perspective on the DR valuation framework. It includes an introduction and four chapters that address the key elements of demand response valuation, a comprehensive literature review, and specific research recommendations.

  8. Robust Unit Commitment Considering Uncertain Demand Response

    DOE PAGESBeta

    Liu, Guodong; Tomsovic, Kevin

    2014-09-28

    Although price responsive demand response has been widely accepted as playing an important role in the reliable and economic operation of power system, the real response from demand side can be highly uncertain due to limited understanding of consumers' response to pricing signals. To model the behavior of consumers, the price elasticity of demand has been explored and utilized in both research and real practice. However, the price elasticity of demand is not precisely known and may vary greatly with operating conditions and types of customers. To accommodate the uncertainty of demand response, alternative unit commitment methods robust to themore » uncertainty of the demand response require investigation. In this paper, a robust unit commitment model to minimize the generalized social cost is proposed for the optimal unit commitment decision taking into account uncertainty of the price elasticity of demand. By optimizing the worst case under proper robust level, the unit commitment solution of the proposed model is robust against all possible realizations of the modeled uncertain demand response. Numerical simulations on the IEEE Reliability Test System show the e ectiveness of the method. Finally, compared to unit commitment with deterministic price elasticity of demand, the proposed robust model can reduce the average Locational Marginal Prices (LMPs) as well as the price volatility.« less

  9. Robust Unit Commitment Considering Uncertain Demand Response

    SciTech Connect

    Liu, Guodong; Tomsovic, Kevin

    2014-09-28

    Although price responsive demand response has been widely accepted as playing an important role in the reliable and economic operation of power system, the real response from demand side can be highly uncertain due to limited understanding of consumers' response to pricing signals. To model the behavior of consumers, the price elasticity of demand has been explored and utilized in both research and real practice. However, the price elasticity of demand is not precisely known and may vary greatly with operating conditions and types of customers. To accommodate the uncertainty of demand response, alternative unit commitment methods robust to the uncertainty of the demand response require investigation. In this paper, a robust unit commitment model to minimize the generalized social cost is proposed for the optimal unit commitment decision taking into account uncertainty of the price elasticity of demand. By optimizing the worst case under proper robust level, the unit commitment solution of the proposed model is robust against all possible realizations of the modeled uncertain demand response. Numerical simulations on the IEEE Reliability Test System show the e ectiveness of the method. Finally, compared to unit commitment with deterministic price elasticity of demand, the proposed robust model can reduce the average Locational Marginal Prices (LMPs) as well as the price volatility.

  10. Strategies for Demand Response in Commercial Buildings

    SciTech Connect

    Watson, David S.; Kiliccote, Sila; Motegi, Naoya; Piette, Mary Ann

    2006-06-20

    This paper describes strategies that can be used in commercial buildings to temporarily reduce electric load in response to electric grid emergencies in which supplies are limited or in response to high prices that would be incurred if these strategies were not employed. The demand response strategies discussed herein are based on the results of three years of automated demand response field tests in which 28 commercial facilities with an occupied area totaling over 11 million ft{sup 2} were tested. Although the demand response events in the field tests were initiated remotely and performed automatically, the strategies used could also be initiated by on-site building operators and performed manually, if desired. While energy efficiency measures can be used during normal building operations, demand response measures are transient; they are employed to produce a temporary reduction in demand. Demand response strategies achieve reductions in electric demand by temporarily reducing the level of service in facilities. Heating ventilating and air conditioning (HVAC) and lighting are the systems most commonly adjusted for demand response in commercial buildings. The goal of demand response strategies is to meet the electric shed savings targets while minimizing any negative impacts on the occupants of the buildings or the processes that they perform. Occupant complaints were minimal in the field tests. In some cases, ''reductions'' in service level actually improved occupant comfort or productivity. In other cases, permanent improvements in efficiency were discovered through the planning and implementation of ''temporary'' demand response strategies. The DR strategies that are available to a given facility are based on factors such as the type of HVAC, lighting and energy management and control systems (EMCS) installed at the site.

  11. Addressing Energy Demand through Demand Response. International Experiences and Practices

    SciTech Connect

    Shen, Bo; Ghatikar, Girish; Ni, Chun Chun; Dudley, Junqiao; Martin, Phil; Wikler, Greg

    2012-06-01

    Demand response (DR) is a load management tool which provides a cost-effective alternative to traditional supply-side solutions to address the growing demand during times of peak electrical load. According to the US Department of Energy (DOE), demand response reflects “changes in electric usage by end-use customers from their normal consumption patterns in response to changes in the price of electricity over time, or to incentive payments designed to induce lower electricity use at times of high wholesale market prices or when system reliability is jeopardized.” 1 The California Energy Commission (CEC) defines DR as “a reduction in customers’ electricity consumption over a given time interval relative to what would otherwise occur in response to a price signal, other financial incentives, or a reliability signal.” 2 This latter definition is perhaps most reflective of how DR is understood and implemented today in countries such as the US, Canada, and Australia where DR is primarily a dispatchable resource responding to signals from utilities, grid operators, and/or load aggregators (or DR providers).

  12. Autonomous Demand Response for Primary Frequency Regulation

    SciTech Connect

    Donnelly, Matt; Trudnowski, Daniel J.; Mattix, S.; Dagle, Jeffery E.

    2012-02-28

    The research documented within this report examines the use of autonomous demand response to provide primary frequency response in an interconnected power grid. The work builds on previous studies in several key areas: it uses a large realistic model (i.e., the interconnection of the western United States and Canada); it establishes a set of metrics that can be used to assess the effectiveness of autonomous demand response; and it independently adjusts various parameters associated with using autonomous demand response to assess effectiveness and to examine possible threats or vulnerabilities associated with the technology.

  13. The alchemy of demand response: turning demand into supply

    SciTech Connect

    Rochlin, Cliff

    2009-11-15

    Paying customers to refrain from purchasing products they want seems to run counter to the normal operation of markets. Demand response should be interpreted not as a supply-side resource but as a secondary market that attempts to correct the misallocation of electricity among electric users caused by regulated average rate tariffs. In a world with costless metering, the DR solution results in inefficiency as measured by deadweight losses. (author)

  14. Coordination of Energy Efficiency and Demand Response

    SciTech Connect

    Goldman, Charles; Reid, Michael; Levy, Roger; Silverstein, Alison

    2010-01-29

    This paper reviews the relationship between energy efficiency and demand response and discusses approaches and barriers to coordinating energy efficiency and demand response. The paper is intended to support the 10 implementation goals of the National Action Plan for Energy Efficiency's Vision to achieve all cost-effective energy efficiency by 2025. Improving energy efficiency in our homes, businesses, schools, governments, and industries - which consume more than 70 percent of the nation's natural gas and electricity - is one of the most constructive, cost-effective ways to address the challenges of high energy prices, energy security and independence, air pollution, and global climate change. While energy efficiency is an increasingly prominent component of efforts to supply affordable, reliable, secure, and clean electric power, demand response is becoming a valuable tool in utility and regional resource plans. The Federal Energy Regulatory Commission (FERC) estimated the contribution from existing U.S. demand response resources at about 41,000 megawatts (MW), about 5.8 percent of 2008 summer peak demand (FERC, 2008). Moreover, FERC recently estimated nationwide achievable demand response potential at 138,000 MW (14 percent of peak demand) by 2019 (FERC, 2009).2 A recent Electric Power Research Institute study estimates that 'the combination of demand response and energy efficiency programs has the potential to reduce non-coincident summer peak demand by 157 GW' by 2030, or 14-20 percent below projected levels (EPRI, 2009a). This paper supports the Action Plan's effort to coordinate energy efficiency and demand response programs to maximize value to customers. For information on the full suite of policy and programmatic options for removing barriers to energy efficiency, see the Vision for 2025 and the various other Action Plan papers and guides available at www.epa.gov/eeactionplan.

  15. Providing Reliability Services through Demand Response: A Prelimnary Evaluation of the Demand Response Capabilities of Alcoa Inc.

    SciTech Connect

    Starke, Michael R; Kirby, Brendan J; Kueck, John D; Todd, Duane; Caulfield, Michael; Helms, Brian

    2009-02-01

    accounts for 30% to 40% of the factory cost of producing primary aluminum. In the continental United States, Alcoa Inc. currently owns and/or operates ten aluminum smelters and many associated fabricating facilities with a combined average load of over 2,600 MW. This presents Alcoa Inc. with a significant opportunity to respond in areas where economic opportunities exist to help mitigate rising energy costs by supplying demand response services into the energy system. This report is organized into seven chapters. The first chapter is the introduction and discusses the intention of this report. The second chapter contains the background. In this chapter, topics include: the motivation for Alcoa to provide demand response; ancillary service definitions; the basics behind aluminum smelting; and a discussion of suggested ancillary services that would be particularly useful for Alcoa to supply. Chapter 3 is concerned with the independent system operator, the Midwest ISO. Here the discussion examines the evolving Midwest ISO market structure including specific definitions, requirements, and necessary components to provide ancillary services. This section is followed by information concerning the Midwest ISO's classifications of demand response parties. Chapter 4 investigates the available opportunities at Alcoa's Warrick facility. Chapter 5 involves an in-depth discussion of the regulation service that Alcoa's Warrick facility can provide and the current interactions with Midwest ISO. Chapter 6 reviews future plans and expectations for Alcoa providing ancillary services into the market. Last, chapter 7, details the conclusion and recommendations of this paper.

  16. Agricultural Irrigation Demand Response Estimation Tool

    SciTech Connect

    Olsen, Daniel

    2014-02-01

    This program is used to model the energy demand of agricultural irrigation pumps, used to maintain soil moisture levels in irrigated fields. This modeling is accomplished using historical data from evapotranspirationmeasuring weather stations (from the California Irrigation Management Information System) as well as irrigation system characteristics for the field(s) to be modeled. The modelled energy demand is used to estimate the achievable demand response (DR) potential of the field(s), for use in assessing the value of the DR for the utility company. The program can accept input data with varying degrees of rigor, and estimate the uncertainty of the output accordingly.

  17. Wireless Demand Response Controls for HVAC Systems

    SciTech Connect

    Federspiel, Clifford

    2009-06-30

    The objectives of this scoping study were to develop and test control software and wireless hardware that could enable closed-loop, zone-temperature-based demand response in buildings that have either pneumatic controls or legacy digital controls that cannot be used as part of a demand response automation system. We designed a SOAP client that is compatible with the Demand Response Automation Server (DRAS) being used by the IOUs in California for their CPP program, design the DR control software, investigated the use of cellular routers for connecting to the DRAS, and tested the wireless DR system with an emulator running a calibrated model of a working building. The results show that the wireless DR system can shed approximately 1.5 Watts per design CFM on the design day in a hot, inland climate in California while keeping temperatures within the limits of ASHRAE Standard 55: Thermal Environmental Conditions for Human Occupancy.

  18. Installation and Commissioning Automated Demand Response Systems

    SciTech Connect

    Global Energy Partners; Pacific Gas and Electric Company; Kiliccote, Sila; Kiliccote, Sila; Piette, Mary Ann; Wikler, Greg; Prijyanonda, Joe; Chiu, Albert

    2008-04-21

    Demand Response (DR) can be defined as actions taken to reduce electric loads when contingencies, such as emergencies and congestion, occur that threaten supply-demand balance, or market conditions raise supply costs. California utilities have offered price and reliability DR based programs to customers to help reduce electric peak demand. The lack of knowledge about the DR programs and how to develop and implement DR control strategies is a barrier to participation in DR programs, as is the lack of automation of DR systems. Most DR activities are manual and require people to first receive notifications, and then act on the information to execute DR strategies. Levels of automation in DR can be defined as follows. Manual Demand Response involves a labor-intensive approach such as manually turning off or changing comfort set points at each equipment switch or controller. Semi-Automated Demand Response involves a pre-programmed demand response strategy initiated by a person via centralized control system. Fully-Automated Demand Response does not involve human intervention, but is initiated at a home, building, or facility through receipt of an external communications signal. The receipt of the external signal initiates pre-programmed demand response strategies. We refer to this as Auto-DR (Piette et. al. 2005). Auto-DR for commercial and industrial facilities can be defined as fully automated DR initiated by a signal from a utility or other appropriate entity and that provides fully-automated connectivity to customer end-use control strategies. One important concept in Auto-DR is that a homeowner or facility manager should be able to 'opt out' or 'override' a DR event if the event comes at time when the reduction in end-use services is not desirable. Therefore, Auto-DR is not handing over total control of the equipment or the facility to the utility but simply allowing the utility to pass on grid related information which then triggers facility defined and programmed

  19. Opportunities for Libraries with Print-on-Demand Publishing

    ERIC Educational Resources Information Center

    Blummer, Barbara

    2005-01-01

    Academic libraries, university presses, and commercial ventures are embracing print-on-demand publishing to improve services as well as reduce costs. The concept dates to the early 1990s, but problems with the technology coupled with a lack of interest by libraries and book vendors hindered its popularity. Today, print-on-demand remains ideal for…

  20. Global Energy: Supply, Demand, Consequences, Opportunities (LBNL Summer Lecture Series)

    SciTech Connect

    Majumdar, Arun

    2008-07-29

    Summer Lecture Series 2009: Arun Majumdar, Director of the Environmental Energy Technologies Division, discusses current and future projections of economic growth, population, and global energy demand and supply, and explores the implications of these trends for the environment.

  1. Global Energy: Supply, Demand, Consequences, Opportunities (LBNL Summer Lecture Series)

    ScienceCinema

    Majumdar, Arun

    2016-07-12

    Summer Lecture Series 2009: Arun Majumdar, Director of the Environmental Energy Technologies Division, discusses current and future projections of economic growth, population, and global energy demand and supply, and explores the implications of these trends for the environment.

  2. Taxonomy for Modeling Demand Response Resources

    SciTech Connect

    Olsen, Daniel; Kiliccote, Sila; Sohn, Michael; Dunn, Laura; Piette, Mary, A

    2014-08-01

    Demand response resources are an important component of modern grid management strategies. Accurate characterizations of DR resources are needed to develop systems of optimally managed grid operations and to plan future investments in generation, transmission, and distribution. The DOE Demand Response and Energy Storage Integration Study (DRESIS) project researched the degree to which demand response (DR) and energy storage can provide grid flexibility and stability in the Western Interconnection. In this work, DR resources were integrated with traditional generators in grid forecasting tools, specifically a production cost model of the Western Interconnection. As part of this study, LBNL developed a modeling framework for characterizing resource availability and response attributes of DR resources consistent with the governing architecture of the simulation modeling platform. In this report, we identify and describe the following response attributes required to accurately characterize DR resources: allowable response frequency, maximum response duration, minimum time needed to achieve load changes, necessary pre- or re-charging of integrated energy storage, costs of enablement, magnitude of controlled resources, and alignment of availability. We describe a framework for modeling these response attributes, and apply this framework to characterize 13 DR resources including residential, commercial, and industrial end-uses. We group these end-uses into three broad categories based on their response capabilities, and define a taxonomy for classifying DR resources within these categories. The three categories of resources exhibit different capabilities and differ in value to the grid. Results from the production cost model of the Western Interconnection illustrate that minor differences in resource attributes can have significant impact on grid utilization of DR resources. The implications of these findings will be explored in future DR valuation studies.

  3. Demand Response For Power System Reliability: FAQ

    SciTech Connect

    Kirby, Brendan J

    2006-12-01

    Demand response is the most underutilized power system reliability resource in North America. Technological advances now make it possible to tap this resource to both reduce costs and improve. Misconceptions concerning response capabilities tend to force loads to provide responses that they are less able to provide and often prohibit them from providing the most valuable reliability services. Fortunately this is beginning to change with some ISOs making more extensive use of load response. This report is structured as a series of short questions and answers that address load response capabilities and power system reliability needs. Its objective is to further the use of responsive load as a bulk power system reliability resource in providing the fastest and most valuable ancillary services.

  4. Load Reduction, Demand Response and Energy Efficient Technologies and Strategies

    SciTech Connect

    Boyd, Paul A.; Parker, Graham B.; Hatley, Darrel D.

    2008-11-19

    The Department of Energy’s (DOE’s) Pacific Northwest National Laboratory (PNNL) was tasked by the DOE Office of Electricity (OE) to recommend load reduction and grid integration strategies, and identify additional demand response (energy efficiency/conservation opportunities) and strategies at the Forest City Housing (FCH) redevelopment at Pearl Harbor and the Marine Corps Base Hawaii (MCBH) at Kaneohe Bay. The goal was to provide FCH staff a path forward to manage their electricity load and thus reduce costs at these FCH family housing developments. The initial focus of the work was at the MCBH given the MCBH has a demand-ratchet tariff, relatively high demand (~18 MW) and a commensurate high blended electricity rate (26 cents/kWh). The peak demand for MCBH occurs in July-August. And, on average, family housing at MCBH contributes ~36% to the MCBH total energy consumption. Thus, a significant load reduction in family housing can have a considerable impact on the overall site load. Based on a site visit to the MCBH and meetings with MCBH installation, FCH, and Hawaiian Electric Company (HECO) staff, recommended actions (including a "smart grid" recommendation) that can be undertaken by FCH to manage and reduce peak-demand in family housing are made. Recommendations are also made to reduce overall energy consumption, and thus reduce demand in FCH family housing.

  5. Grid Integration of Aggregated Demand Response, Part 2: Modeling Demand Response in a Production Cost Model

    SciTech Connect

    Hummon, Marissa; Palchak, David; Denholm, Paul; Jorgenson, Jennie; Olsen, Daniel J.; Kiliccote, Sila; Matson, Nance; Sohn, Michael; Rose, Cody; Dudley, Junqiao; Goli, Sasank; Ma, Ookie

    2013-12-01

    This report is one of a series stemming from the U.S. Department of Energy (DOE) Demand Response and Energy Storage Integration Study. This study is a multi-national-laboratory effort to assess the potential value of demand response (DR) and energy storage to electricity systems with different penetration levels of variable renewable resources and to improve our understanding of associatedmarkets and institutions. This report implements DR resources in the commercial production cost model PLEXOS.

  6. Demand responsive programs - an emerging resource for competitive electricity markets?

    SciTech Connect

    Heffner, Grayson C. Dr.; Goldman, Charles A.

    2001-06-25

    The restructuring of regional electricity markets in the U.S. has been accompanied by numerous problems, including generation capacity shortages, transmission congestion, wholesale price volatility, and reduced system reliability. These problems have created significant new opportunities for technologies and business approaches that allow load serving entities and other aggregators, to control and manage the load patterns of their wholesale or retail end-users. These technologies and business approaches for manipulating end-user load shapes are known as Load Management or, more recently, Demand Responsive programs. Lawrence Berkeley National Laboratory (LBNL) is conducting case studies on innovative demand responsive programs and presents preliminary results for five case studies in this paper. These case studies illustrate the diversity of market participants and range of technologies and business approaches and focus on key program elements such as target markets, market segmentation and participation results; pricing scheme; dispatch and coordination; measurement, verification, and settlement; and operational results where available.

  7. Stakeholders in Recovery: Demands, Expectations, and Research Opportunities

    PubMed Central

    McCarty, Dennis; Zammarelli, Lucy; Wylie, Hillary; Greenlick, Merwyn R.

    2005-01-01

    A broad array of agencies, institutions, and individuals interact with community-based substance abuse treatment programs, providing resources or services and asserting demands and expectations in return. These relationships shape the environment in which treatment and community-based research take place, and themselves raise issues worthy of research attention. This article enumerates the stakeholders in one well-established program and describes the scope of the program’s efforts to accommodate these stakeholders, along with some of the complications and difficulties programs confront in their attempts to satisfy stakeholders, especially when their demands are unrealistic or their interests conflict. The article concludes by identifying research areas that could facilitate these relationships, enhancing their benefits for patients. PMID:18552745

  8. Home Network Technologies and Automating Demand Response

    SciTech Connect

    McParland, Charles

    2009-12-01

    Over the past several years, interest in large-scale control of peak energy demand and total consumption has increased. While motivated by a number of factors, this interest has primarily been spurred on the demand side by the increasing cost of energy and, on the supply side by the limited ability of utilities to build sufficient electricity generation capacity to meet unrestrained future demand. To address peak electricity use Demand Response (DR) systems are being proposed to motivate reductions in electricity use through the use of price incentives. DR systems are also be design to shift or curtail energy demand at critical times when the generation, transmission, and distribution systems (i.e. the 'grid') are threatened with instabilities. To be effectively deployed on a large-scale, these proposed DR systems need to be automated. Automation will require robust and efficient data communications infrastructures across geographically dispersed markets. The present availability of widespread Internet connectivity and inexpensive, reliable computing hardware combined with the growing confidence in the capabilities of distributed, application-level communications protocols suggests that now is the time for designing and deploying practical systems. Centralized computer systems that are capable of providing continuous signals to automate customers reduction of power demand, are known as Demand Response Automation Servers (DRAS). The deployment of prototype DRAS systems has already begun - with most initial deployments targeting large commercial and industrial (C & I) customers. An examination of the current overall energy consumption by economic sector shows that the C & I market is responsible for roughly half of all energy consumption in the US. On a per customer basis, large C & I customers clearly have the most to offer - and to gain - by participating in DR programs to reduce peak demand. And, by concentrating on a small number of relatively sophisticated

  9. Demand side management in India: Opportunities and challenges

    SciTech Connect

    Nezhad, H.G.; Mehta, J.V.

    1997-06-01

    India`s electricity demand has been growing by more than 8% per year over the last decade. However, despite the fact that more than 70% of its 130 million households do not have access to electricity, demand for electricity has outstripped supply resulting in frequent blackouts and routine brownouts. India`s per capita consumption of electricity is about 240 KWh compared to about 500 KWh in other developing countries and 7,000 KWh in developed nations. According to the Fifteenth Power Survey by Indian Ministry of Energy, per capita energy consumption is projected to grow at about 5.5% per year until 2020, when India`s population is projected to reach 1.2 billion people. Based on these projections, India will need a generating capacity of 450,000 MW in 2020, compared to the current capacity of about 80,000 MW. Considering rising costs, limited fuel supply, and shortages of capital for power plant construction, it is unlikely that projected capacity will be realized. The only viable option would be to utilize available power through intensive energy efficiency improvements and load management.

  10. Opportunities and prospects for demand-side efficiency improvements

    SciTech Connect

    Kuliasha, M.A.

    1993-12-31

    Substantial progress has been made over the last 20 years in improving energy efficiency in all sectors of the US economy. Although there remains a large potential for further efficiency gains, progress in improving energy efficiency has slowed recently. A combination of low energy prices, environmental challenges, and life-style changes have caused energy consumption to resume rising. Both new policies and technologies will be necessary to achieve cost-effective levels of energy efficiency. This paper describes some of the promising new demand-side technologies that are currently being implemented, nearing commercialization, or in advanced stages of development. The topics discussed include finding replacements for chlorofluorocarbons (CFCs), new building equipment and envelope technologies, lessons learned about conservation program implementation, and the role of utilities in promoting the efficient use of energy.

  11. Laboratory Testing of Demand-Response Enabled Household Appliances

    SciTech Connect

    Sparn, B.; Jin, X.; Earle, L.

    2013-10-01

    With the advent of the Advanced Metering Infrastructure (AMI) systems capable of two-way communications between the utility's grid and the building, there has been significant effort in the Automated Home Energy Management (AHEM) industry to develop capabilities that allow residential building systems to respond to utility demand events by temporarily reducing their electricity usage. Major appliance manufacturers are following suit by developing Home Area Network (HAN)-tied appliance suites that can take signals from the home's 'smart meter,' a.k.a. AMI meter, and adjust their run cycles accordingly. There are numerous strategies that can be employed by household appliances to respond to demand-side management opportunities, and they could result in substantial reductions in electricity bills for the residents depending on the pricing structures used by the utilities to incent these types of responses. The first step to quantifying these end effects is to test these systems and their responses in simulated demand-response (DR) conditions while monitoring energy use and overall system performance.

  12. Laboratory Testing of Demand-Response Enabled Household Appliances

    SciTech Connect

    Sparn, B.; Jin, X.; Earle, L.

    2013-10-01

    With the advent of the Advanced Metering Infrastructure (AMI) systems capable of two-way communications between the utility's grid and the building, there has been significant effort in the Automated Home Energy Management (AHEM) industry to develop capabilities that allow residential building systems to respond to utility demand events by temporarily reducing their electricity usage. Major appliance manufacturers are following suit by developing Home Area Network (HAN)-tied appliance suites that can take signals from the home's 'smart meter,' a.k.a. AMI meter, and adjust their run cycles accordingly. There are numerous strategies that can be employed by household appliances to respond to demand-side management opportunities, and they could result in substantial reductions in electricity bills for the residents depending on the pricing structures used by the utilities to incent these types of responses.The first step to quantifying these end effects is to test these systems and their responses in simulated demand-response (DR) conditions while monitoring energy use and overall system performance.

  13. Retail Demand Response in Southwest Power Pool

    SciTech Connect

    Bharvirkar, Ranjit; Heffner, Grayson; Goldman, Charles

    2009-01-30

    In 2007, the Southwest Power Pool (SPP) formed the Customer Response Task Force (CRTF) to identify barriers to deploying demand response (DR) resources in wholesale markets and develop policies to overcome these barriers. One of the initiatives of this Task Force was to develop more detailed information on existing retail DR programs and dynamic pricing tariffs, program rules, and utility operating practices. This report describes the results of a comprehensive survey conducted by LBNL in support of the Customer Response Task Force and discusses policy implications for integrating legacy retail DR programs and dynamic pricing tariffs into wholesale markets in the SPP region. LBNL conducted a detailed survey of existing DR programs and dynamic pricing tariffs administered by SPP's member utilities. Survey respondents were asked to provide information on advance notice requirements to customers, operational triggers used to call events (e.g. system emergencies, market conditions, local emergencies), use of these DR resources to meet planning reserves requirements, DR resource availability (e.g. seasonal, annual), participant incentive structures, and monitoring and verification (M&V) protocols. Nearly all of the 30 load-serving entities in SPP responded to the survey. Of this group, fourteen SPP member utilities administer 36 DR programs, five dynamic pricing tariffs, and six voluntary customer response initiatives. These existing DR programs and dynamic pricing tariffs have a peak demand reduction potential of 1,552 MW. Other major findings of this study are: o About 81percent of available DR is from interruptible rate tariffs offered to large commercial and industrial customers, while direct load control (DLC) programs account for ~;;14percent. o Arkansas accounts for ~;;50percent of the DR resources in the SPP footprint; these DR resources are primarily managed by cooperatives. o Publicly-owned cooperatives accounted for 54percent of the existing DR resources

  14. Measurement and evaluation techniques for automated demand response demonstration

    SciTech Connect

    Motegi, Naoya; Piette, Mary Ann; Watson, David S.; Sezgen, Osman; ten Hope, Laurie

    2004-08-01

    The recent electricity crisis in California and elsewhere has prompted new research to evaluate demand response strategies in large facilities. This paper describes an evaluation of fully automated demand response technologies (Auto-DR) in five large facilities. Auto-DR does not involve human intervention, but is initiated at a facility through receipt of an external communications signal. This paper summarizes the measurement and evaluation of the performance of demand response technologies and strategies in five large facilities. All the sites have data trending systems such as energy management and control systems (EMCS) and/or energy information systems (EIS). Additional sub-metering was applied where necessary to evaluate the facility's demand response performance. This paper reviews the control responses during the test period, and analyzes demand savings achieved at each site. Occupant comfort issues are investigated where data are available. This paper discusses methods to estimate demand savings and results from demand response strategies at five large facilities.

  15. Northwest Open Automated Demand Response Technology Demonstration Project

    SciTech Connect

    Kiliccote, Sila; Piette, Mary Ann; Dudley, Junqiao

    2010-03-17

    The Lawrence Berkeley National Laboratory (LBNL) Demand Response Research Center (DRRC) demonstrated and evaluated open automated demand response (OpenADR) communication infrastructure to reduce winter morning and summer afternoon peak electricity demand in commercial buildings the Seattle area. LBNL performed this demonstration for the Bonneville Power Administration (BPA) in the Seattle City Light (SCL) service territory at five sites: Seattle Municipal Tower, Seattle University, McKinstry, and two Target stores. This report describes the process and results of the demonstration. OpenADR is an information exchange model that uses a client-server architecture to automate demand-response (DR) programs. These field tests evaluated the feasibility of deploying fully automated DR during both winter and summer peak periods. DR savings were evaluated for several building systems and control strategies. This project studied DR during hot summer afternoons and cold winter mornings, both periods when electricity demand is typically high. This is the DRRC project team's first experience using automation for year-round DR resources and evaluating the flexibility of commercial buildings end-use loads to participate in DR in dual-peaking climates. The lessons learned contribute to understanding end-use loads that are suitable for dispatch at different times of the year. The project was funded by BPA and SCL. BPA is a U.S. Department of Energy agency headquartered in Portland, Oregon and serving the Pacific Northwest. BPA operates an electricity transmission system and markets wholesale electrical power at cost from federal dams, one non-federal nuclear plant, and other non-federal hydroelectric and wind energy generation facilities. Created by the citizens of Seattle in 1902, SCL is the second-largest municipal utility in America. SCL purchases approximately 40% of its electricity and the majority of its transmission from BPA through a preference contract. SCL also provides

  16. Open Automated Demand Response Communications in Demand Response for Wholesale Ancillary Services

    SciTech Connect

    Kiliccote, Sila; Piette, Mary Ann; Ghatikar, Girish; Koch, Ed; Hennage, Dan; Hernandez, John; Chiu, Albert; Sezgen, Osman; Goodin, John

    2009-11-06

    The Pacific Gas and Electric Company (PG&E) is conducting a pilot program to investigate the technical feasibility of bidding certain demand response (DR) resources into the California Independent System Operator's (CAISO) day-ahead market for ancillary services nonspinning reserve. Three facilities, a retail store, a local government office building, and a bakery, are recruited into the pilot program. For each facility, hourly demand, and load curtailment potential are forecasted two days ahead and submitted to the CAISO the day before the operation as an available resource. These DR resources are optimized against all other generation resources in the CAISO ancillary service. Each facility is equipped with four-second real time telemetry equipment to ensure resource accountability and visibility to CAISO operators. When CAISO requests DR resources, PG&E's OpenADR (Open Automated DR) communications infrastructure is utilized to deliver DR signals to the facilities energy management and control systems (EMCS). The pre-programmed DR strategies are triggered without a human in the loop. This paper describes the automated system architecture and the flow of information to trigger and monitor the performance of the DR events. We outline the DR strategies at each of the participating facilities. At one site a real time electric measurement feedback loop is implemented to assure the delivery of CAISO dispatched demand reductions. Finally, we present results from each of the facilities and discuss findings.

  17. Progress toward Producing Demand-Response-Ready Appliances

    SciTech Connect

    Hammerstrom, Donald J.; Sastry, Chellury

    2009-12-01

    This report summarizes several historical and ongoing efforts to make small electrical demand-side devices like home appliances more responsive to the dynamic needs of electric power grids. Whereas the utility community often reserves the word demand response for infrequent 2 to 6 hour curtailments that reduce total electrical system peak load, other beneficial responses and ancillary services that may be provided by responsive electrical demand are of interest. Historically, demand responses from the demand side have been obtained by applying external, retrofitted, controlled switches to existing electrical demand. This report is directed instead toward those manufactured products, including appliances, that are able to provide demand responses as soon as they are purchased and that require few, or no, after-market modifications to make them responsive to needs of power grids. Efforts to be summarized include Open Automated Demand Response, the Association of Home Appliance Manufacturer standard CHA 1, a simple interface being developed by the U-SNAP Alliance, various emerging autonomous responses, and the recent PinBus interface that was developed at Pacific Northwest National Laboratory.

  18. Interoperability of Demand Response Resources Demonstration in NY

    SciTech Connect

    Wellington, Andre

    2014-03-31

    The Interoperability of Demand Response Resources Demonstration in NY (Interoperability Project) was awarded to Con Edison in 2009. The objective of the project was to develop and demonstrate methodologies to enhance the ability of customer sited Demand Response resources to integrate more effectively with electric delivery companies and regional transmission organizations.

  19. Demand-Side Response from Industrial Loads

    SciTech Connect

    Starke, Michael R; Alkadi, Nasr E; Letto, Daryl; Johnson, Brandon; Dowling, Kevin; George, Raoule; Khan, Saqib

    2013-01-01

    Through a research study funded by the Department of Energy, Smart Grid solutions company ENBALA Power Networks along with the Oak Ridge National Laboratory (ORNL) have geospatially quantified the potential flexibility within industrial loads to leverage their inherent process storage to help support the management of the electricity grid. The study found that there is an excess of 12 GW of demand-side load flexibility available in a select list of top industrial facilities in the United States. Future studies will expand on this quantity of flexibility as more in-depth analysis of different industries is conducted and demonstrations are completed.

  20. Demand response compensation, net Benefits and cost allocation: comments

    SciTech Connect

    Hogan, William W.

    2010-11-15

    FERC's Supplemental Notice of Public Rulemaking addresses the question of proper compensation for demand response in organized wholesale electricity markets. Assuming that the Commission would proceed with the proposal ''to require tariff provisions allowing demand response resources to participate in wholesale energy markets by reducing consumption of electricity from expected levels in response to price signals, to pay those demand response resources, in all hours, the market price of energy for such reductions,'' the Commission posed questions about applying a net benefits test and rules for cost allocation. This article summarizes critical points and poses implications for the issues of net benefit tests and cost allocation. (author)

  1. Rates and technologies for mass-market demand response

    SciTech Connect

    Herter, Karen; Levy, Roger; Wilson, John; Rosenfeld, Arthur

    2002-07-21

    Demand response programs are often quickly and poorly crafted in reaction to an energy crisis and disappear once the crisis subsides, ensuring that the electricity system will be unprepared when the next crisis hits. In this paper, we propose to eliminate the event-driven nature of demand response programs by considering demand responsiveness a component of the utility obligation to serve. As such, demand response can be required as a condition of service, and the offering of demand response rates becomes a requirement of utilities as an element of customer service. Using this foundation, we explore the costs and benefits of a smart thermostat-based demand response system capable of two types of programs: (1) a mandatory, system-operator controlled, contingency program, and (2) a voluntary, customer controlled, bill management program with rate-based incentives. Any demand response program based on this system could consist of either or both of these components. Ideally, these programs would be bundled, providing automatic load management through customer-programmed price response, plus up to 10 GW of emergency load shedding capability in California. Finally, we discuss options for and barriers to implementation of such a program in California.

  2. Assessment of Industrial Load for Demand Response across Western Interconnect

    SciTech Connect

    Alkadi, Nasr E; Starke, Michael R; Ma, Ookie

    2013-11-01

    Demand response (DR) has the ability to both increase power grid reliability and potentially reduce operating system costs. Understanding the role of demand response in grid modeling has been difficult due to complex nature of the load characteristics compared to the modeled generation and the variation in load types. This is particularly true of industrial loads, where hundreds of different industries exist with varying availability for demand response. We present a framework considering industrial loads for the development of availability profiles that can provide more regional understanding and can be inserted into analysis software for further study. The developed framework utilizes a number of different informational resources, algorithms, and real-world measurements to perform a bottom-up approach in the development of a new database with representation of the potential demand response resource in the industrial sector across the U.S. This tool houses statistical values of energy and demand response (DR) potential by industrial plant and geospatially locates the information for aggregation for different territories without proprietary information. This report will discuss this framework and the analyzed quantities of demand response for Western Interconnect (WI) in support of evaluation of the cost production modeling with power grid modeling efforts of demand response.

  3. Open Automated Demand Response Communications Specification (Version 1.0)

    SciTech Connect

    Piette, Mary Ann; Ghatikar, Girish; Kiliccote, Sila; Koch, Ed; Hennage, Dan; Palensky, Peter; McParland, Charles

    2009-02-28

    The development of the Open Automated Demand Response Communications Specification, also known as OpenADR or Open Auto-DR, began in 2002 following the California electricity crisis. The work has been carried out by the Demand Response Research Center (DRRC), which is managed by Lawrence Berkeley National Laboratory. This specification describes an open standards-based communications data model designed to facilitate sending and receiving demand response price and reliability signals from a utility or Independent System Operator to electric customers. OpenADR is one element of the Smart Grid information and communications technologies that are being developed to improve optimization between electric supply and demand. The intention of the open automated demand response communications data model is to provide interoperable signals to building and industrial control systems that are preprogrammed to take action based on a demand response signal, enabling a demand response event to be fully automated, with no manual intervention. The OpenADR specification is a flexible infrastructure to facilitate common information exchange between the utility or Independent System Operator and end-use participants. The concept of an open specification is intended to allow anyone to implement the signaling systems, the automation server or the automation clients.

  4. Pediatric surgical capacity and demand: analysis reveals a modest gap in capacity and additional efficiency opportunities.

    PubMed

    Fixler, Tamas; Menaker, Rena J; Blair, Geoffrey K; Wright, James G

    2011-01-01

    The Canadian Paediatric Surgical Wait Times Project conducted an analysis of the alignment between capacity (supply) and demand for pediatric surgery at nine participating hospitals in five provinces. Demand for surgery was modelled using wait list data by assigning patients into monthly buckets of demand ("demand windows") based on the date on which a decision was made to proceed with their surgery plus their surgical wait time access target. Demand was then related to available capacity for various key resources (e.g., operating room availability, intensive care unit [ICU] and in-patient beds). The results indicate a small and not insurmountable gap of 8.5-11% in pediatric surgical capacity at these hospitals. A further capacity issue at many hospitals was ICU occupancy. In addition, an examination of several key performance indicators related to the management of peri-operative resources indicated that opportunities exist for deploying existing resources more efficiently, such as increasing on-time starts and reducing cancellation rates for elective surgery.

  5. Role of Storage and Demand Response, Greening the Grid

    SciTech Connect

    2015-09-01

    Greening the Grid provides technical assistance to energy system planners, regulators, and grid operators to overcome challenges associated with integrating variable renewable energy into the grid. This document, part of a Greening the Grid toolkit, examines storage and demand response as means to match renewable energy supply with demand.

  6. System proportions fluid-flow in response to demand signals

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Control system provides proportioned fluid flow rates in response to demand signals. It compares a digital signal, representing a flow demand, with a reference signal to yield a control voltage to one or more solenoid valves connected to orifices of a predetermined size.

  7. The Role of Demand Response in Default Service Pricing

    SciTech Connect

    Barbose, Galen; Goldman, Charles; Neenan, Bernie

    2006-04-15

    In designing default service for competitive retail markets, demand response has been an afterthought at best. But that may be changing, as states that initiated customer choice in the past five to seven years reach an important juncture in retail market design and consider an RTP-type default service for large commercial and industrial customers. The authors describe the experience to date with RTP as a default service, focusing on its role as an instrument for cultivating price-responsive demand. (author)

  8. On the demand for prescription drugs: heterogeneity in price responses.

    PubMed

    Skipper, Niels

    2013-07-01

    This paper estimates the price elasticity of demand for prescription drugs using an exogenous shift in consumer co-payment caused by a reform in the Danish subsidy scheme for the general public. Using purchasing records for the entire Danish population, I show that the average price response for the most commonly used drug yields demand elasticities in the range of -0.36 to -0.5. The reform is shown to affect women, the elderly, and immigrants the most. Furthermore, this paper shows significant heterogeneity in the price response over different types of antibiotics, suggesting that the price elasticity of demand varies considerably even across relatively similar drugs. PMID:22899231

  9. Automated Demand Response Strategies and Commissioning CommercialBuilding Controls

    SciTech Connect

    Piette, Mary Ann; Watson, David; Motegi, Naoya; Kiliccote, Sila; Linkugel, Eric

    2006-05-01

    California electric utilities have been exploring the use of dynamic critical peak pricing (CPP) and other demand response programs to help reduce peaks in customer electric loads. CPP is a new electricity tariff design to promote demand response. This paper begins with a brief review of terminology regarding energy management and demand response, followed by a discussion of DR control strategies and a preliminary overview of a forthcoming guide on DR strategies. The final section discusses experience to date with these strategies, followed by a discussion of the peak electric demand savings from the 2005 Automated CPP program. An important concept identified in the automated DR field tests is that automated DR will be most successful if the building commissioning industry improves the operational effectiveness of building controls. Critical peak pricing and even real time pricing are important trends in electricity pricing that will require new functional tests for building commissioning.

  10. Open Automated Demand Response for Small Commerical Buildings

    SciTech Connect

    Dudley, June Han; Piette, Mary Ann; Koch, Ed; Hennage, Dan

    2009-05-01

    This report characterizes small commercial buildings by market segments, systems and end-uses; develops a framework for identifying demand response (DR) enabling technologies and communication means; and reports on the design and development of a low-cost OpenADR enabling technology that delivers demand reductions as a percentage of the total predicted building peak electric demand. The results show that small offices, restaurants and retail buildings are the major contributors making up over one third of the small commercial peak demand. The majority of the small commercial buildings in California are located in southern inland areas and the central valley. Single-zone packaged units with manual and programmable thermostat controls make up the majority of heating ventilation and air conditioning (HVAC) systems for small commercial buildings with less than 200 kW peak electric demand. Fluorescent tubes with magnetic ballast and manual controls dominate this customer group's lighting systems. There are various ways, each with its pros and cons for a particular application, to communicate with these systems and three methods to enable automated DR in small commercial buildings using the Open Automated Demand Response (or OpenADR) communications infrastructure. Development of DR strategies must consider building characteristics, such as weather sensitivity and load variability, as well as system design (i.e. under-sizing, under-lighting, over-sizing, etc). Finally, field tests show that requesting demand reductions as a percentage of the total building predicted peak electric demand is feasible using the OpenADR infrastructure.

  11. Rates and technologies for mass-market demand response

    SciTech Connect

    Herter, Karen; Levy, Roger; Wilson, John; Rosenfeld, Arthur

    2002-07-21

    Demand response programs are often quickly and poorlycrafted in reaction to an energy crisis and disappear once the crisissubsides, ensuring that the electricity system will be unprepared whenthe next crisis hits. In this paper, we propose to eliminate theevent-driven nature of demand response programs by considering demandresponsiveness a component of the utility obligation to serve. As such,demand response can be required as a condition of service, and theoffering of demand response rates becomes a requirement of utilities asan element of customer service. Using this foundation, we explore thecosts and benefits of a smart thermostat-based demand response systemcapable of two types of programs: (1) a mandatory, system-operatorcontrolled, contingency program, and (2) a voluntary, customercontrolled, bill management program with rate-based incentives. Anydemand response program based on this system could consist of either orboth of these components. Ideally, these programs would be bundled,providing automatic load management through customer-programmed priceresponse, plus up to 10 GW of emergency load shedding capability inCalifornia. Finally, we discuss options for and barriers toimplementation of such a program in California.

  12. Quantifying Changes in Building Electricity Use, with Application to Demand Response

    SciTech Connect

    Mathieu, Johanna L.; Price, Phillip N.; Kiliccote, Sila; Piette, Mary Ann

    2010-11-17

    We present methods for analyzing commercial and industrial facility 15-minute-interval electric load data. These methods allow building managers to better understand their facility's electricity consumption over time and to compare it to other buildings, helping them to ask the right questions to discover opportunities for demand response, energy efficiency, electricity waste elimination, and peak load management. We primarily focus on demand response. Methods discussed include graphical representations of electric load data, a regression-based electricity load model that uses a time-of-week indicator variable and a piecewise linear and continuous outdoor air temperature dependence, and the definition of various parameters that characterize facility electricity loads and demand response behavior. In the future, these methods could be translated into easy-to-use tools for building managers.

  13. The rate of metabolism in marine animals: environmental constraints, ecological demands and energetic opportunities.

    PubMed

    Seibel, Brad A; Drazen, Jeffrey C

    2007-11-29

    The rates of metabolism in animals vary tremendously throughout the biosphere. The origins of this variation are a matter of active debate with some scientists highlighting the importance of anatomical or environmental constraints, while others emphasize the diversity of ecological roles that organisms play and the associated energy demands. Here, we analyse metabolic rates in diverse marine taxa, with special emphasis on patterns of metabolic rate across a depth gradient, in an effort to understand the extent and underlying causes of variation. The conclusion from this analysis is that low rates of metabolism, in the deep sea and elsewhere, do not result from resource (e.g. food or oxygen) limitation or from temperature or pressure constraint. While metabolic rates do decline strongly with depth in several important animal groups, for others metabolism in abyssal species proceeds as fast as in ecologically similar shallow-water species at equivalent temperatures. Rather, high metabolic demand follows strong selection for locomotory capacity among visual predators inhabiting well-lit oceanic waters. Relaxation of this selection where visual predation is limited provides an opportunity for reduced energy expenditure. Large-scale metabolic variation in the ocean results from interspecific differences in ecological energy demand. PMID:17510016

  14. Can an Opportunity to Learn at Work Reduce Stress?: A Revisitation of the Job Demand-Control Model

    ERIC Educational Resources Information Center

    Panari, Chiara; Guglielmi, Dina; Simbula, Silvia; Depolo, Marco

    2010-01-01

    Purpose: This paper aims to extend the stress-buffering hypothesis of the demand-control model. In addition to the control variable, it seeks to analyse the role of an opportunity for learning and development (L&D) in the workplace as a moderator variable between increased demands and need for recovery. Design/methodology/approach: A questionnaire…

  15. Modeling, Analysis, and Control of Demand Response Resources

    SciTech Connect

    Mathieu, Johanna L.

    2012-05-01

    While the traditional goal of an electric power system has been to control supply to fulfill demand, the demand-side can plan an active role in power systems via Demand Response (DR), defined by the Department of Energy (DOE) as “a tariff or program established to motivate changes in electric use by end-use customers in response to changes in the price of electricity over time, or to give incentive payments designed to induce lower electricity use at times of high market prices or when grid reliability is jeopardized” [29]. DR can provide a variety of benefits including reducing peak electric loads when the power system is stressed and fast timescale energy balancing. Therefore, DR can improve grid reliability and reduce wholesale energy prices and their volatility. This dissertation focuses on analyzing both recent and emerging DR paradigms. Recent DR programs have focused on peak load reduction in commercial buildings and industrial facilities (C&I facilities). We present methods for using 15-minute-interval electric load data, commonly available from C&I facilities, to help building managers understand building energy consumption and ‘ask the right questions’ to discover opportunities for DR. Additionally, we present a regression-based model of whole building electric load, i.e., a baseline model, which allows us to quantify DR performance. We use this baseline model to understand the performance of 38 C&I facilities participating in an automated dynamic pricing DR program in California. In this program, facilities are expected to exhibit the same response each DR event. We find that baseline model error makes it difficult to precisely quantify changes in electricity consumption and understand if C&I facilities exhibit event-to-event variability in their response to DR signals. Therefore, we present a method to compute baseline model error and a metric to determine how much observed DR variability results from baseline model error rather than real

  16. Evaluation of Representative Smart Grid Investment Project Technologies: Demand Response

    SciTech Connect

    Fuller, Jason C.; Prakash Kumar, Nirupama; Bonebrake, Christopher A.

    2012-02-14

    This document is one of a series of reports estimating the benefits of deploying technologies similar to those implemented on the Smart Grid Investment Grant (SGIG) projects. Four technical reports cover the various types of technologies deployed in the SGIG projects, distribution automation, demand response, energy storage, and renewables integration. A fifth report in the series examines the benefits of deploying these technologies on a national level. This technical report examines the impacts of a limited number of demand response technologies and implementations deployed in the SGIG projects.

  17. Canadian demand for highly qualified personnel for therapeutic evaluation: an opportunity for academic institutions.

    PubMed

    MacLeod, Stuart M; Soon, Judith A; Sharma, Sunaina; Wiens, Matthew O

    2014-01-01

    Achievement of optimal therapeutics requires individuals with analytic skills appropriate to the balancing of enterprise, innovation and the need for rigorous scientific validation. A synergistic convergence of discovery research, clinical investigation, evaluative, regulatory and implementation sciences will be essential. None of the needed research capacities are likely to prove obtainable on demand. On the contrary, they require accurate projection of future needs and careful planning of post-secondary training programs. A survey conducted for Health Canada in 2010 revealed significant shortfalls in research skills available outside government and industry. This commentary argues that such an environment represents an outstanding opportunity for the academic community to demonstrate that it is eager to meet the needs of the Canadian public. University leaders should be assertive about their commitment to the ideals of patient oriented research and all governments should be clear about deliverables anticipated in return for consistent post-secondary funding. PMID:25347149

  18. Organizational Response to the Demand and Expectation for Diversity

    ERIC Educational Resources Information Center

    Siegel, David J.

    2006-01-01

    This study examines the interplay of institutional environments and organizational contexts in shaping the responses of four professional schools (public health, business, social work, and engineering) to diversity-related pressures, expectations, requirements, and incentives. The role of market demand in structuring postsecondary approaches to…

  19. Electric Water Heater Modeling and Control Strategies for Demand Response

    SciTech Connect

    Diao, Ruisheng; Lu, Shuai; Elizondo, Marcelo A.; Mayhorn, Ebony T.; Zhang, Yu; Samaan, Nader A.

    2012-07-22

    Abstract— Demand response (DR) has a great potential to provide balancing services at normal operating conditions and emergency support when a power system is subject to disturbances. Effective control strategies can significantly relieve the balancing burden of conventional generators and reduce investment on generation and transmission expansion. This paper is aimed at modeling electric water heaters (EWH) in households and tests their response to control strategies to implement DR. The open-loop response of EWH to a centralized signal is studied by adjusting temperature settings to provide regulation services; and two types of decentralized controllers are tested to provide frequency support following generator trips. EWH models are included in a simulation platform in DIgSILENT to perform electromechanical simulation, which contains 147 households in a distribution feeder. Simulation results show the dependence of EWH response on water heater usage . These results provide insight suggestions on the need of control strategies to achieve better performance for demand response implementation. Index Terms— Centralized control, decentralized control, demand response, electrical water heater, smart grid

  20. Physiological response to ''pressure-demand'' respirator wear

    SciTech Connect

    Raven, P.B.; Bradley, O.; Rohm-Young, D.; McClure, F.L.; Skaggs, B.

    1982-07-01

    This investigation determined cardiorespiratory responses of subjects with normal lung function and exercise tolerance and compared them with subjects with moderate impairment of lung function and exercise tolerance. The respirator was an air-line full-face mask (MSA-Ultravue) ''pressure-demand'' breathing type equipped with an inspiratory resistance of 85 mmH/sub 2/0 at 85 L/min air flow. This resistance was operable in conjunction with the fixed 25 mmH/sub 2/O inspiratory and expiratory resistance required to pressurize the face piece. Physiologically and subjectively the response of the normal and moderately impaired subjects to respirator wear during rest, 35%, 50% and 80% of their maximal aerobic capacity (VO/sub 2//sub max/) were not different. However, the pressure swings inside the face piece exceeded 24 cm H/sub 2/O and resulted in 50% of the subjects being unable to finish 10 minutes of work at 80% VO/sub 2//sub max/. The greater the ventilatory demand placed upon the respirator due to increasing workload, the more like a ''demand'' system pressure-flow response the ''pressure-demand'' system produced. Hence, the concept of increased protection and reduced inspiratory resistance as a result of pressurizing the facepiece during heavy work is seriously questioned.

  1. Linking Continuous Energy Management and Open Automated Demand Response

    SciTech Connect

    Piette, Mary Ann; Kiliccote, Sila; Ghatikar, Girish

    2008-10-03

    Advances in communications and control technology, the strengthening of the Internet, and the growing appreciation of the urgency to reduce demand side energy use are motivating the development of improvements in both energy efficiency and demand response (DR) systems. This paper provides a framework linking continuous energy management and continuous communications for automated demand response (Auto-DR) in various times scales. We provide a set of concepts for monitoring and controls linked to standards and procedures such as Open Automation Demand Response Communication Standards (Open Auto-DR or OpenADR). Basic building energy science and control issues in this approach begin with key building components, systems, end-uses and whole building energy performance metrics. The paper presents a framework about when energy is used, levels of services by energy using systems, granularity of control, and speed of telemetry. DR, when defined as a discrete event, requires a different set of building service levels than daily operations. We provide examples of lessons from DR case studies and links to energy efficiency.

  2. The Role of Demand Response in Default Service Pricing

    SciTech Connect

    Barbose, Galen; Goldman, Chuck; Neenan, Bernie

    2006-03-10

    Dynamic retail electricity pricing, especially real-time pricing (RTP), has been widely heralded as a panacea for providing much-needed demand response in electricity markets. However, in designing default service for competitive retail markets, demand response often appears to be an afterthought. But that may be changing as states that initiated customer choice in the past 5-7 years reach an important juncture in retail market design. Most states with retail choice established an initial transitional period, during which utilities were required to offer a default or ''standard offer'' generation service, often at a capped or otherwise administratively-determined rate. Many retail choice states have reached, or are nearing, the end of their transitional period and several states have adopted an RTP-type default service for large commercial and industrial (C&I) customers. Are these initiatives motivated by the desire to induce greater demand response, or is RTP being called upon to serve a different role in competitive markets? Surprisingly, we found that in most cases, the primary reason for adopting RTP as the default service was not to encourage demand response, but rather to advance policy objectives related to the development of competitive retail markets. However, we also find that, if efforts are made in its design and implementation, default RTP service can also provide a solid foundation for developing price responsive demand, creating an important link between wholesale and retail market transactions. This paper, which draws from a lengthier report, describes the experience to date with default RTP in the U.S., identifying findings related to its actual and potential role as an instrument for cultivating price responsive demand [1]. For each of the five states currently with default RTP, we conducted a detailed review of the regulatory proceedings leading to its adoption. To further understand the intentions and expectations of those involved in its design

  3. Mass Market Demand Response and Variable Generation Integration Issues: A Scoping Study

    SciTech Connect

    Cappers, Peter; Mills, Andrew; Goldman, Charles; Wiser, Ryan; Eto, Joseph H.

    2011-09-10

    This scoping study focuses on the policy issues inherent in the claims made by some Smart Grid proponents that the demand response potential of mass market customers which is enabled by widespread implementation of Advanced Metering Infrastructure (AMI) through the Smart Grid could be the “silver bullet” for mitigating variable generation integration issues. In terms of approach, we will: identify key issues associated with integrating large amounts of variable generation into the bulk power system; identify demand response opportunities made more readily available to mass market customers through widespread deployment of AMI systems and how they can affect the bulk power system; assess the extent to which these mass market Demand Response (DR) opportunities can mitigate Variable Generation (VG) integration issues in the near-term and what electricity market structures and regulatory practices could be changed to further expand the ability for DR to mitigate VG integration issues over the long term; and provide a qualitative comparison of DR and other approaches to mitigate VG integration issues.

  4. Effects of Demand Response on Retail and Wholesale Power Markets

    SciTech Connect

    Chassin, David P.; Kalsi, Karanjit

    2012-07-26

    Demand response has grown to be a part of the repertoire of resources used by utilities to manage the balance between generation and load. In recent years, advances in communications and control technology have enabled utilities to consider continuously controlling demand response to meet generation, rather than the other way around. This paper discusses the economic applications of a general method for load resource analysis that parallels the approach used to analyze generation resources and uses the method to examine the results of the US Department of Energy’s Olympic Peninsula Demonstration Testbed. A market-based closed-loop system of controllable assets is discussed with necessary and sufficient conditions on system controllability, observability and stability derived.

  5. 10 CFR 9.203 - Procedure where response to demand is required prior to receiving instructions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Procedure where response to demand is required prior to... or Disclosure in Response to Subpoenas or Demands of Courts or Other Authorities § 9.203 Procedure where response to demand is required prior to receiving instructions. If a response to the demand...

  6. The Role of Demand Response in Default Service Pricing

    SciTech Connect

    Barbose, Galen; Goldman, Charles; Neenan, Bernie

    2005-11-09

    Dynamic retail pricing, especially real-time pricing (RTP), has been widely heralded as a panacea for providing much-needed demand response in electricity markets. However, in designing default service for competitive retail markets, demand response has been an afterthought, and in some cases not given any weight at all. But that may be changing, as states that initiated customer choice in the past 5-7 years reach an important juncture in retail market design. Most states with retail choice established an initial transitional period during which utilities were required to offer a default or standard offer generation service, often at a capped or otherwise administratively-determined rate. Many retail choice states have reached the end of their transitional period, and several have adopted or are actively considering an RTP-type default service for large commercial and industrial (C&I) customers. In most cases, the primary reason for adopting RTP as the default service has been to advance policy objectives related to the development of competitive retail markets. However, if attention is paid in its design and implementation, default RTP service can also provide a solid foundation for developing price responsive demand, creating an important link between wholesale and retail market transactions. This article, which draws from a lengthier report, describes experience to date with RTP as a default service, focusing on its role as an instrument for cultivating price responsive demand.1 As of summer 2005, default service RTP was in place or approved for future implementation in five U.S. states: New Jersey, Maryland, Pennsylvania, New York, and Illinois. For each of these states, we conducted a detailed review of the regulatory proceedings leading to adoption of default RTP and interviewed regulatory staff and utilities in these states, as well as eight competitive retail suppliers active in these markets.

  7. A Distributed Intelligent Automated Demand Response Building Management System

    SciTech Connect

    Auslander, David; Culler, David; Wright, Paul; Lu, Yan; Piette, Mary

    2013-12-30

    The goal of the 2.5 year Distributed Intelligent Automated Demand Response (DIADR) project was to reduce peak electricity load of Sutardja Dai Hall at UC Berkeley by 30% while maintaining a healthy, comfortable, and productive environment for the occupants. We sought to bring together both central and distributed control to provide “deep” demand response1 at the appliance level of the building as well as typical lighting and HVAC applications. This project brought together Siemens Corporate Research and Siemens Building Technology (the building has a Siemens Apogee Building Automation System (BAS)), Lawrence Berkeley National Laboratory (leveraging their Open Automated Demand Response (openADR), Auto-­Demand Response, and building modeling expertise), and UC Berkeley (related demand response research including distributed wireless control, and grid-­to-­building gateway development). Sutardja Dai Hall houses the Center for Information Technology Research in the Interest of Society (CITRIS), which fosters collaboration among industry and faculty and students of four UC campuses (Berkeley, Davis, Merced, and Santa Cruz). The 141,000 square foot building, occupied in 2009, includes typical office spaces and a nanofabrication laboratory. Heating is provided by a district heating system (steam from campus as a byproduct of the campus cogeneration plant); cooling is provided by one of two chillers: a more typical electric centrifugal compressor chiller designed for the cool months (Nov-­ March) and a steam absorption chiller for use in the warm months (April-­October). Lighting in the open office areas is provided by direct-­indirect luminaries with Building Management System-­based scheduling for open areas, and occupancy sensors for private office areas. For the purposes of this project, we focused on the office portion of the building. Annual energy consumption is approximately 8053 MWh; the office portion is estimated as 1924 MWh. The maximum peak load

  8. Demand Response in the West: Lessons for States and Provinces

    SciTech Connect

    Douglas C. Larson; Matt Lowry; Sharon Irwin

    2004-06-29

    OAK-B135 This paper is submitted in fulfillment of DOE Grant No. DE-FG03-015F22369 on the experience of western states/provinces with demand response (DR) in the electricity sector. Demand-side resources are often overlooked as a viable option for meeting load growth and addressing the challenges posed by the region's aging transmission system. Western states should work together with utilities and grid operators to facilitate the further deployment of DR programs which can provide benefits in the form of decreased grid congestion, improved system reliability, market efficiency, price stabilization, hedging against volatile fuel prices and reduced environmental impacts of energy production. This report describes the various types of DR programs; provides a survey of DR programs currently in place in the West; considers the benefits, drawbacks and barriers to DR; and presents lessons learned and recommendations for states/provinces.

  9. The Impact of Uncertain Physical Parameters on HVAC Demand Response

    SciTech Connect

    Sun, Yannan; Elizondo, Marcelo A.; Lu, Shuai; Fuller, Jason C.

    2014-03-01

    HVAC units are currently one of the major resources providing demand response (DR) in residential buildings. Models of HVAC with DR function can improve understanding of its impact on power system operations and facilitate the deployment of DR technologies. This paper investigates the importance of various physical parameters and their distributions to the HVAC response to DR signals, which is a key step to the construction of HVAC models for a population of units with insufficient data. These parameters include the size of floors, insulation efficiency, the amount of solid mass in the house, and efficiency of the HVAC units. These parameters are usually assumed to follow Gaussian or Uniform distributions. We study the effect of uncertainty in the chosen parameter distributions on the aggregate HVAC response to DR signals, during transient phase and in steady state. We use a quasi-Monte Carlo sampling method with linear regression and Prony analysis to evaluate sensitivity of DR output to the uncertainty in the distribution parameters. The significance ranking on the uncertainty sources is given for future guidance in the modeling of HVAC demand response.

  10. Automated Demand Response: The Missing Link in the Electricity Value Chain

    SciTech Connect

    McKane, Aimee; Rhyne, Ivin; Piette, Mary Ann; Thompson, Lisa; Lekov, Alex

    2008-08-01

    In 2006, the Public Interest Energy Research Program (PIER) Demand Response Research Center (DRRC) at Lawrence Berkeley National Laboratory initiated research into Automated Demand Response (OpenADR) applications in California industry. The goal is to improve electric grid reliability and lower electricity use during periods of peak demand. The purpose of this research is to begin to define the relationship among a portfolio of actions that industrial facilities can undertake relative to their electricity use. This 'electricity value chain' defines energy management and demand response (DR) at six levels of service, distinguished by the magnitude, type, and rapidity of response. One element in the electricity supply chain is OpenADR, an open-standards based communications system to send signals to customers to allow them to manage their electric demand in response to supply conditions, such as prices or reliability, through a set of standard, open communications. Initial DRRC research suggests that industrial facilities that have undertaken energy efficiency measures are probably more, not less, likely to initiate other actions within this value chain such as daily load management and demand response. Moreover, OpenADR appears to afford some facilities the opportunity to develop the supporting control structure and to 'demo' potential reductions in energy use that can later be applied to either more effective load management or a permanent reduction in use via energy efficiency. Under the right conditions, some types of industrial facilities can shift or shed loads, without any, or minimal disruption to operations, to protect their energy supply reliability and to take advantage of financial incentives. In 2007 and 2008, 35 industrial facilities agreed to implement OpenADR, representing a total capacity of nearly 40 MW. This paper describes how integrated or centralized demand management and system-level network controls are linked to OpenADR systems. Case studies

  11. Automated Demand Response: The Missing Link in the Electricity Value Chain

    SciTech Connect

    McKane, Aimee; Rhyne, Ivin; Lekov, Alex; Thompson, Lisa; Piette, MaryAnn

    2009-08-01

    In 2006, the Public Interest Energy Research Program (PIER) Demand Response Research Center (DRRC) at Lawrence Berkeley National Laboratory initiated research into Automated Demand Response (OpenADR) applications in California industry. The goal is to improve electric grid reliability and lower electricity use during periods of peak demand. The purpose of this research is to begin to define the relationship among a portfolio of actions that industrial facilities can undertake relative to their electricity use. This ?electricity value chain? defines energy management and demand response (DR) at six levels of service, distinguished by the magnitude, type, and rapidity of response. One element in the electricity supply chain is OpenADR, an open-standards based communications system to send signals to customers to allow them to manage their electric demand in response to supply conditions, such as prices or reliability, through a set of standard, open communications. Initial DRRC research suggests that industrial facilities that have undertaken energy efficiency measures are probably more, not less, likely to initiate other actions within this value chain such as daily load management and demand response. Moreover, OpenADR appears to afford some facilities the opportunity to develop the supporting control structure and to"demo" potential reductions in energy use that can later be applied to either more effective load management or a permanent reduction in use via energy efficiency. Under the right conditions, some types of industrial facilities can shift or shed loads, without any, or minimal disruption to operations, to protect their energy supply reliability and to take advantage of financial incentives.1 In 2007 and 2008, 35 industrial facilities agreed to implement OpenADR, representing a total capacity of nearly 40 MW. This paper describes how integrated or centralized demand management and system-level network controls are linked to OpenADR systems. Case studies

  12. Demand Response Resources for Energy and Ancillary Services (Presentation)

    SciTech Connect

    Hummon, M.

    2014-04-01

    Demand response (DR) resources present a potentially important source of grid flexibility particularly on future systems with high penetrations of variable wind an solar power generation. However, DR in grid models is limited by data availability and modeling complexity. This presentation focuses on the co-optimization of DR resources to provide energy and ancillary services in a production cost model of the Colorado test system. We assume each DR resource can provide energy services by either shedding load or shifting its use between different times, as well as operating

  13. Demand response, behind-the-meter generation and air quality.

    PubMed

    Zhang, Xiyue; Zhang, K Max

    2015-02-01

    We investigated the implications of behind-the-meter (BTM) generation participating in demand response (DR) programs. Specifically, we evaluated the impacts of NOx emissions from BTM generators enrolled in the New York Independent System Operator (NYISO)'s reliability-based DR programs. Through analyzing the DR program enrollment data, DR event records, ozone air quality monitoring data, and emission characteristics of the generators, we found that the emissions from BTM generators very likely contribute to exceedingly high ozone concentrations in the Northeast Corridor region, and very likely account for a substantial fraction of total NOx emissions from electricity generation. In addition, a companion study showed that the emissions from BTM generators could also form near-source particulate matter (PM) hotspots. The important policy implications are that the absence of up-to-date regulations on BTM generators may offset the current efforts to reduce the emissions from peaking power plants, and that there is a need to quantify the environmental impacts of DR programs in designing sound policies related to demand-side resources. Furthermore, we proposed the concept of "Green" DR resources, referring to those that not only provide power systems reliability services, but also have verifiable environmental benefits or minimal negative environmental impacts. We argue that Green DR resources that are able to maintain resource adequacy and reduce emissions at the same time are key to achieving the cobenefits of power system reliability and protecting public health during periods with peak electricity demand. PMID:25556780

  14. Demand response, behind-the-meter generation and air quality.

    PubMed

    Zhang, Xiyue; Zhang, K Max

    2015-02-01

    We investigated the implications of behind-the-meter (BTM) generation participating in demand response (DR) programs. Specifically, we evaluated the impacts of NOx emissions from BTM generators enrolled in the New York Independent System Operator (NYISO)'s reliability-based DR programs. Through analyzing the DR program enrollment data, DR event records, ozone air quality monitoring data, and emission characteristics of the generators, we found that the emissions from BTM generators very likely contribute to exceedingly high ozone concentrations in the Northeast Corridor region, and very likely account for a substantial fraction of total NOx emissions from electricity generation. In addition, a companion study showed that the emissions from BTM generators could also form near-source particulate matter (PM) hotspots. The important policy implications are that the absence of up-to-date regulations on BTM generators may offset the current efforts to reduce the emissions from peaking power plants, and that there is a need to quantify the environmental impacts of DR programs in designing sound policies related to demand-side resources. Furthermore, we proposed the concept of "Green" DR resources, referring to those that not only provide power systems reliability services, but also have verifiable environmental benefits or minimal negative environmental impacts. We argue that Green DR resources that are able to maintain resource adequacy and reduce emissions at the same time are key to achieving the cobenefits of power system reliability and protecting public health during periods with peak electricity demand.

  15. Quantifying stock-price response to demand fluctuations

    NASA Astrophysics Data System (ADS)

    Plerou, Vasiliki; Gopikrishnan, Parameswaran; Gabaix, Xavier; Stanley, H. Eugene

    2002-08-01

    We empirically address the question of how stock prices respond to changes in demand. We quantify the relations between price change G over a time interval Δt and two different measures of demand fluctuations: (a) Φ, defined as the difference between the number of buyer-initiated and seller-initiated trades, and (b) Ω, defined as the difference in number of shares traded in buyer- and seller-initiated trades. We find that the conditional expectation functions of price change for a given Φ or Ω, Φ and Ω (``market impact function''), display concave functional forms that seem universal for all stocks. For small Ω, we find a power-law behavior Ω~Ω1/8 with δ depending on Δt (δ~3 for Δt=5 min, δ~3/2 for Δt=15 min and δ~1 for large Δt). We find that large price fluctuations occur when demand is very small-a fact that is reminiscent of large fluctuations that occur at critical points in spin systems, where the divergent nature of the response function leads to large fluctuations.

  16. Quantifying stock-price response to demand fluctuations.

    PubMed

    Plerou, Vasiliki; Gopikrishnan, Parameswaran; Gabaix, Xavier; Stanley, H Eugene

    2002-08-01

    We empirically address the question of how stock prices respond to changes in demand. We quantify the relations between price change G over a time interval Deltat and two different measures of demand fluctuations: (a) Phi, defined as the difference between the number of buyer-initiated and seller-initiated trades, and (b) Omega, defined as the difference in number of shares traded in buyer- and seller-initiated trades. We find that the conditional expectation functions of price change for a given Phi or Omega, (Phi) and (Omega) ("market impact function"), display concave functional forms that seem universal for all stocks. For small Omega, we find a power-law behavior (Omega) approximately Omega(1/8) with delta depending on Deltat (delta approximately 3 for Deltat=5 min, delta approximately 3/2 for Deltat=15 min and delta approximately 1 for large Deltat). We find that large price fluctuations occur when demand is very small-a fact that is reminiscent of large fluctuations that occur at critical points in spin systems, where the divergent nature of the response function leads to large fluctuations. PMID:12241320

  17. Role of Standard Demand Response Signals for Advanced Automated Aggregation

    SciTech Connect

    Lawrence Berkeley National Laboratory; Kiliccote, Sila

    2011-11-18

    Emerging standards such as OpenADR enable Demand Response (DR) Resources to interact directly with Utilities and Independent System Operators to allow their facility automation equipment to respond to a variety of DR signals ranging from day ahead to real time ancillary services. In addition, there are Aggregators in today’s markets who are capable of bringing together collections of aggregated DR assets and selling them to the grid as a single resource. However, in most cases these aggregated resources are not automated and when they are, they typically use proprietary technologies. There is a need for a framework for dealing with aggregated resources that supports the following requirements: • Allows demand-side resources to participate in multiple DR markets ranging from wholesale ancillary services to retail tariffs without being completely committed to a single entity like an Aggregator; • Allow aggregated groups of demand-side resources to be formed in an ad hoc fashion to address specific grid-side issues and support the optimization of the collective response of an aggregated group along a number of different dimensions. This is important in order to taylor the aggregated performance envelope to the needs to of the grid; • Allow aggregated groups to be formed in a hierarchical fashion so that each group can participate in variety of markets from wholesale ancillary services to distribution level retail tariffs. This paper explores the issues of aggregated groups of DR resources as described above especially within the context of emerging smart grid standards and the role they will play in both the management and interaction of various grid-side entities with those resources.

  18. Demand Intensity, Market Parameters and Policy Responses towards Demand and Supply of Private Supplementary Tutoring in China

    ERIC Educational Resources Information Center

    Kwok, Percy Lai Yin

    2010-01-01

    Based on some longitudinal studies of private tutoring in twelve cities, towns, municipalities and provinces of China, the paper endeavours to depict demand intensity, articulate market parameters and reflect on policy responses towards the demand-supply mechanism of the vast shadowy educational phenomena at primary and secondary levels. Such…

  19. Identifying Demand Responses to Illegal Drug Supply Interdictions.

    PubMed

    Cunningham, Scott; Finlay, Keith

    2016-10-01

    Successful supply-side interdictions into illegal drug markets are predicated on the responsiveness of drug prices to enforcement and the price elasticity of demand for addictive drugs. We present causal estimates that targeted interventions aimed at methamphetamine input markets ('precursor control') can temporarily increase retail street prices, but methamphetamine consumption is weakly responsive to higher drug prices. After the supply interventions, purity-adjusted prices increased then quickly returned to pre-treatment levels within 6-12 months, demonstrating the short-term effects of precursor control. The price elasticity of methamphetamine demand is -0.13 to -0.21 for self-admitted drug treatment admissions and between -0.24 and -0.28 for hospital inpatient admissions. We find some evidence of a positive cross-price effect for cocaine, but we do not find robust evidence that increases in methamphetamine prices increased heroin, alcohol, or marijuana drug use. This study can inform policy discussions regarding other synthesized drugs, including illicit use of pharmaceuticals. Copyright © 2015 John Wiley & Sons, Ltd. PMID:26216390

  20. Demand Response Performance of GE Hybrid Heat Pump Water Heater

    SciTech Connect

    Widder, Sarah H.; Parker, Graham B.; Petersen, Joseph M.; Baechler, Michael C.

    2013-07-01

    This report describes a project to evaluate and document the DR performance of HPWH as compared to ERWH for two primary types of DR events: peak curtailments and balancing reserves. The experiments were conducted with GE second-generation “Brillion”-enabled GeoSpring hybrid water heaters in the PNNL Lab Homes, with one GE GeoSpring water heater operating in “Standard” electric resistance mode to represent the baseline and one GE GeoSpring water heater operating in “Heat Pump” mode to provide the comparison to heat pump-only demand response. It is expected that “Hybrid” DR performance, which would engage both the heat pump and electric elements, could be interpolated from these two experimental extremes. Signals were sent simultaneously to the two water heaters in the side-by-side PNNL Lab Homes under highly controlled, simulated occupancy conditions. This report presents the results of the evaluation, which documents the demand-response capability of the GE GeoSpring HPWH for peak load reduction and regulation services. The sections describe the experimental protocol and test apparatus used to collect data, present the baselining procedure, discuss the results of the simulated DR events for the HPWH and ERWH, and synthesize key conclusions based on the collected data.

  1. A Hybrid Demand Response Simulator Version 1.0

    2012-05-02

    A hybrid demand response simulator is developed to test different control algorithms for centralized and distributed demand response (DR) programs in a small distribution power grid. The HDRS is designed to model a wide variety of DR services such as peak having, load shifting, arbitrage, spinning reserves, load following, regulation, emergency load shedding, etc. The HDRS does not model the dynamic behaviors of the loads, rather, it simulates the load scheduling and dispatch process. Themore » load models include TCAs (water heaters, air conditioners, refrigerators, freezers, etc) and non-TCAs (lighting, washer, dishwasher, etc.) The ambient temperature changes, thermal resistance, capacitance, and the unit control logics can be modeled for TCA loads. The use patterns of the non-TCA can be modeled by probability of use and probabilistic durations. Some of the communication network characteristics, such as delays and errors, can also be modeled. Most importantly, because the simulator is modular and greatly simplified the thermal models for TCA loads, it is very easy and fast to be used to test and validate different control algorithms in a simulated environment.« less

  2. Demand Response in U.S. Electricity Markets: Empirical Evidence

    SciTech Connect

    Cappers, Peter; Goldman, Charles; Kathan, David

    2009-06-01

    Empirical evidence concerning demand response (DR) resources is needed in order to establish baseline conditions, develop standardized methods to assess DR availability and performance, and to build confidence among policymakers, utilities, system operators, and stakeholders that DR resources do offer a viable, cost-effective alternative to supply-side investments. This paper summarizes the existing contribution of DR resources in U.S. electric power markets. In 2008, customers enrolled in existing wholesale and retail DR programs were capable of providing ~;;38,000 MW of potential peak load reductions in the United States. Participants in organized wholesale market DR programs, though, have historically overestimated their likely performance during declared curtailments events, but appear to be getting better as they and their agents gain experience. In places with less developed organized wholesale market DR programs, utilities are learning how to create more flexible DR resources by adapting legacy load management programs to fit into existing wholesale market constructs. Overall, the development of open and organized wholesale markets coupled with direct policy support by the Federal Energy Regulatory Commission has facilitated new entry by curtailment service providers, which has likely expanded the demand response industry and led to product and service innovation.

  3. 12 CFR 602.23 - Responses to demands served on FCA employees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Responses to demands served on FCA employees....23 Responses to demands served on FCA employees. (a) An employee served with a demand or a subpoena... documents described in the demand, and all relevant facts. (b) When the Chairman does not allow testimony...

  4. Direct versus Facility Centric Load Control for Automated Demand Response

    SciTech Connect

    Koch, Ed; Piette, Mary Ann

    2009-11-06

    Direct load control (DLC) refers to the scenario where third party entities outside the home or facility are responsible for deciding how and when specific customer loads will be controlled in response to Demand Response (DR) events on the electric grid. Examples of third parties responsible for performing DLC may be Utilities, Independent System Operators (ISO), Aggregators, or third party control companies. DLC can be contrasted with facility centric load control (FCLC) where the decisions for how loads are controlled are made entirely within the facility or enterprise control systems. In FCLC the facility owner has more freedom of choice in how to respond to DR events on the grid. Both approaches are in use today in automation of DR and both will continue to be used in future market segments including industrial, commercial and residential facilities. This paper will present a framework which can be used to differentiate between DLC and FCLC based upon where decisions are made on how specific loads are controlled in response to DR events. This differentiation is then used to compare and contrast the differences between DLC and FCLC to identify the impact each has on:(1)Utility/ISO and third party systems for managing demand response, (2)Facility systems for implementing load control, (3)Communications networks for interacting with the facility and (4)Facility operators and managers. Finally a survey of some of the existing DR related specifications and communications standards is given and their applicability to DLC or FCLC. In general FCLC adds more cost and responsibilities to the facilities whereas DLC represents higher costs and complexity for the Utility/ISO. This difference is primarily due to where the DR Logic is implemented and the consequences that creates. DLC may be more certain than FCLC because it is more predictable - however as more loads have the capability to respond to DR signals, people may prefer to have their own control of end-use loads

  5. Running demands and heart rate response in rugby sevens referees.

    PubMed

    Suarez-Arrones, Luis; Calvo-Lluch, África; Portillo, Javier; Sánchez, Francisco; Mendez-Villanueva, Alberto

    2013-06-01

    The purpose of this study was to examine for the first time the match running demands and heart rate (HR) responses associated with elite rugby sevens referees. Twelve referees were analyzed over 38 games, using Global Positioning System. Referees covered an average distance of 1665.2 ± 203.5 m per game (15.1 ± 0.5 minutes). Over this distance, 22.3% (371.8 ± 48.9 m) was spent standing and walking, 25.9% (431.2 ± 92.6 m) jogging, 12.4% (206.5 ± 53.2 m) cruising, 23.8% (395.6 ± 94.3 m) striding, 8% (133.3 ± 61.6 m) high-intensity running, and 7.6% (126.7 ± 87.3 m) sprinting. The average maximal distance of sprints, the number of sprints, and the mean sprint distance over the game were 31.3 ± 13.4 m, 5.76 ± 3.6 sprints, and 19.9 ± 7.8 m, respectively. The referee's work-to-rest ratio was 3.5:1. There were no statistical differences between the first and second half in any of the running variables analyzed. The average HR in the second half (160 ± 9 b·min(-1); 86 ± 5% maximal heart rate (HRmax) of the estimated) was higher (p < 0.05) than the HR recorded in the first half (154 ± 11 b·min(-1); 83 ± 6% of the estimated HRmax). This study also suggests that the physical demands of referring in rugby sevens are quite different from those encountered in other rugby codes, and the training regimes need to meet the increased overall running demands and high-intensity running activity.

  6. Integration of Renewables Via Demand Management: Highly Dispatchable and Distributed Demand Response for the Integration of Distributed Generation

    SciTech Connect

    2012-02-11

    GENI Project: AutoGrid, in conjunction with Lawrence Berkeley National Laboratory and Columbia University, will design and demonstrate automated control software that helps manage real-time demand for energy across the electric grid. Known as the Demand Response Optimization and Management System - Real-Time (DROMS-RT), the software will enable personalized price signal to be sent to millions of customers in extremely short timeframes—incentivizing them to alter their electricity use in response to grid conditions. This will help grid operators better manage unpredictable demand and supply fluctuations in short time-scales —making the power generation process more efficient and cost effective for both suppliers and consumers. DROMS-RT is expected to provide a 90% reduction in the cost of operating demand response and dynamic pricing Projects in the U.S.

  7. Pilot Testing of Commercial Refrigeration-Based Demand Response

    SciTech Connect

    Hirsch, Adam; Clark, Jordan; Deru, Michael; Trenbath, Kim; Doebber, Ian; Studer, Daniel

    2015-10-08

    Supermarkets potentially offer a substantial demand response (DR) resource because of their high energy intensity and use patterns. This report describes a pilot project conducted to better estimate supermarket DR potential. Previous work has analyzed supermarket DR using heating, ventilating, and air conditioning (HVAC), lighting, and anti-condensate heaters. This project was concerned with evaluating DR using the refrigeration system and quantifying the DR potential inherent in supermarket refrigeration systems. Ancillary aims of the project were to identify practical barriers to the implementation of DR programs in supermarkets and to determine which high-level control strategies were most appropriate for achieving certain DR objectives. The scope of this project does not include detailed control strategy development for DR or development of a strategy for regional implementation of DR in supermarkets.

  8. A Generalized Formulation of Demand Response under Market Environments

    NASA Astrophysics Data System (ADS)

    Nguyen, Minh Y.; Nguyen, Duc M.

    2015-06-01

    This paper presents a generalized formulation of Demand Response (DR) under deregulated electricity markets. The problem is scheduling and controls the consumption of electrical loads according to the market price to minimize the energy cost over a day. Taking into account the modeling of customers' comfort (i.e., preference), the formulation can be applied to various types of loads including what was traditionally classified as critical loads (e.g., air conditioning, lights). The proposed DR scheme is based on Dynamic Programming (DP) framework and solved by DP backward algorithm in which the stochastic optimization is used to treat the uncertainty, if any occurred in the problem. The proposed formulation is examined with the DR problem of different loads, including Heat Ventilation and Air Conditioning (HVAC), Electric Vehicles (EVs) and a newly DR on the water supply systems of commercial buildings. The result of simulation shows significant saving can be achieved in comparison with their traditional (On/Off) scheme.

  9. Value of Demand Response: Quantities from Production Cost Modeling (Presentation)

    SciTech Connect

    Hummon, M.

    2014-04-01

    Demand response (DR) resources present a potentially important source of grid flexibility particularly on future systems with high penetrations of variable wind and solar power generation. However, managed loads in grid models are limited by data availability and modeling complexity. This presentation focuses on the value of co-optimized DR resources to provide energy and ancillary services in a production cost model. There are significant variations in the availabilities of different types of DR resources, which affect both the operational savings as well as the revenue for each DR resource. The results presented include the system-wide avoided fuel and generator start-up costs as well as the composite revenue for each DR resource by energy and operating reserves. In addition, the revenue is characterized by the capacity, energy, and units of DR enabled.

  10. Scenarios for Consuming Standardized Automated Demand Response Signals

    SciTech Connect

    Koch, Ed; Piette, Mary Ann

    2008-10-03

    Automated Demand Response (DR) programs require that Utility/ISO's deliver DR signals to participants via a machine to machine communications channel. Typically these DR signals constitute business logic information (e.g. prices and reliability/shed levels) as opposed to commands to control specific loads in the facility. At some point in the chain from the Utility/ISO to the loads in a facility, the business level information sent by the Utility/ISO must be processed and used to execute a DR strategy for the facility. This paper explores the various scenarios and types of participants that may utilize DR signals from the Utility/ISO. Specifically it explores scenarios ranging from single end user facility, to third party facility managers and DR Aggregators. In each of these scenarios it is pointed out where the DR signal sent from the Utility/ISO is processed and turned into the specific load control commands that are part of a DR strategy for a facility. The information in these signals is discussed. In some cases the DR strategy will be completely embedded in the facility while in others it may be centralized at a third party (e.g. Aggregator) and part of an aggregated set of facilities. This paper also discusses the pros and cons of the various scenarios and discusses how the Utility/ISO can use an open standardized method (e.g. Open Automated Demand Response Communication Standards) for delivering DR signals that will promote interoperability and insure that the widest range of end user facilities can participate in DR programs regardless of which scenario they belong to.

  11. 32 CFR 725.10 - Response to requests or demands in conflict with this instruction.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Response to requests or demands in conflict with... DEPARTMENT OF THE NAVY PERSONNEL § 725.10 Response to requests or demands in conflict with this instruction... any official DOD information in response to a litigation request or demand without prior...

  12. 6 CFR 5.46 - Procedure when response to demand is required prior to receiving instructions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Procedure when response to demand is required....46 Procedure when response to demand is required prior to receiving instructions. (a) If a response to a demand is required before the appropriate Department official designated in § 5.44 renders...

  13. 45 CFR 1201.7 - Procedure when response to demand is required prior to receiving instructions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Procedure when response to demand is required..., INTERROGATORIES, OR IN CONNECTION WITH FEDERAL OR STATE LITIGATION § 1201.7 Procedure when response to demand is required prior to receiving instructions. (a) If a response to a demand or request for Official...

  14. 22 CFR 172.6 - Procedure when response to demand is required prior to receiving instructions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Procedure when response to demand is required... demand is required prior to receiving instructions. (a) If a response to a demand is required before the... INFORMATION SERVICE OF PROCESS; PRODUCTION OR DISCLOSURE OF OFFICIAL INFORMATION IN RESPONSE TO COURT...

  15. 34 CFR 8.4 - What procedures are followed in response to a demand for testimony?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What procedures are followed in response to a demand... TESTIMONY OR RECORDS IN LEGAL PROCEEDINGS § 8.4 What procedures are followed in response to a demand for...) If a response to a demand for testimony is required before the Secretary determines whether to...

  16. Technology Transfer Opportunities: On-Demand Printing in Support of National Geospatial Data

    USGS Publications Warehouse

    ,

    1997-01-01

    The U.S. Geological Survey (USGS) and the 3M Company of St. Paul, Minnesota, have entered into a cooperative research and development agreement (CRADA) to investigate maps-on-demand technology to support the production of USGS mapping products. The CRADA will potentially help the USGS to develop on-demand alternatives to lithographic maps and help 3M to develop a series of commercial instant map-printing systems.

  17. Northwest Open Automated Demand Response Technology Demonstration Project

    SciTech Connect

    Kiliccote, Sila; Dudley, Junqiao Han; Piette, Mary Ann

    2009-08-01

    Lawrence Berkeley National Laboratory (LBNL) and the Demand Response Research Center (DRRC) performed a technology demonstration and evaluation for Bonneville Power Administration (BPA) in Seattle City Light's (SCL) service territory. This report summarizes the process and results of deploying open automated demand response (OpenADR) in Seattle area with winter morning peaking commercial buildings. The field tests were designed to evaluate the feasibility of deploying fully automated demand response (DR) in four to six sites in the winter and the savings from various building systems. The project started in November of 2008 and lasted 6 months. The methodology for the study included site recruitment, control strategy development, automation system deployment and enhancements, and evaluation of sites participation in DR test events. LBNL subcontracted McKinstry and Akuacom for this project. McKinstry assisted with recruitment, site survey collection, strategy development and overall participant and control vendor management. Akuacom established a new server and enhanced its operations to allow for scheduling winter morning day-of and day-ahead events. Each site signed a Memorandum of Agreement with SCL. SCL offered each site $3,000 for agreeing to participate in the study and an additional $1,000 for each event they participated. Each facility and their control vendor worked with LBNL and McKinstry to select and implement control strategies for DR and developed their automation based on the existing Internet connectivity and building control system. Once the DR strategies were programmed, McKinstry commissioned them before actual test events. McKinstry worked with LBNL to identify control points that can be archived at each facility. For each site LBNL collected meter data and trend logs from the energy management and control system. The communication system allowed the sites to receive day-ahead as well as day-of DR test event signals. Measurement of DR was

  18. 12 CFR 602.24 - Responses to demands served on non-FCA employees or entities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Responses to demands served on non-FCA... Not a Named Party § 602.24 Responses to demands served on non-FCA employees or entities. If you are not an employee and are served with a demand or a subpoena in a legal proceeding directing you...

  19. 34 CFR 8.5 - What procedures are followed in response to a demand for records?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What procedures are followed in response to a demand... TESTIMONY OR RECORDS IN LEGAL PROCEEDINGS § 8.5 What procedures are followed in response to a demand for... demand under rules governing public disclosure, as established in 34 CFR part 5. (b) An employee may...

  20. 12 CFR 1703.39 - Responses to demands served on employees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Responses to demands served on employees. 1703... Production of Documents in Legal Proceedings in Which OFHEO Is Not a Named Party § 1703.39 Responses to demands served on employees. (a) Advice by employee served. Any employee who is served with a demand in...

  1. An Informatics Approach to Demand Response Optimization in Smart Grids

    SciTech Connect

    Simmhan, Yogesh; Aman, Saima; Cao, Baohua; Giakkoupis, Mike; Kumbhare, Alok; Zhou, Qunzhi; Paul, Donald; Fern, Carol; Sharma, Aditya; Prasanna, Viktor K

    2011-03-03

    Power utilities are increasingly rolling out “smart” grids with the ability to track consumer power usage in near real-time using smart meters that enable bidirectional communication. However, the true value of smart grids is unlocked only when the veritable explosion of data that will become available is ingested, processed, analyzed and translated into meaningful decisions. These include the ability to forecast electricity demand, respond to peak load events, and improve sustainable use of energy by consumers, and are made possible by energy informatics. Information and software system techniques for a smarter power grid include pattern mining and machine learning over complex events and integrated semantic information, distributed stream processing for low latency response,Cloud platforms for scalable operations and privacy policies to mitigate information leakage in an information rich environment. Such an informatics approach is being used in the DoE sponsored Los Angeles Smart Grid Demonstration Project, and the resulting software architecture will lead to an agile and adaptive Los Angeles Smart Grid.

  2. Open Automated Demand Response Dynamic Pricing Technologies and Demonstration

    SciTech Connect

    Ghatikar, Girish; Mathieu, Johanna L.; Piette, Mary Ann; Koch, Ed; Hennage, Dan

    2010-08-02

    This study examines the use of OpenADR communications specification, related data models, technologies, and strategies to send dynamic prices (e.g., real time prices and peak prices) and Time of Use (TOU) rates to commercial and industrial electricity customers. OpenADR v1.0 is a Web services-based flexible, open information model that has been used in California utilities' commercial automated demand response programs since 2007. We find that data models can be used to send real time prices. These same data models can also be used to support peak pricing and TOU rates. We present a data model that can accommodate all three types of rates. For demonstration purposes, the data models were generated from California Independent System Operator's real-time wholesale market prices, and a California utility's dynamic prices and TOU rates. Customers can respond to dynamic prices by either using the actual prices, or prices can be mapped into"operation modes," which can act as inputs to control systems. We present several different methods for mapping actual prices. Some of these methods were implemented in demonstration projects. The study results demonstrate show that OpenADR allows interoperability with existing/future systems/technologies and can be used within related dynamic pricing activities within Smart Grid.

  3. Building Fluent Performance: Measuring Response Rate and Multiplying Response Opportunities

    ERIC Educational Resources Information Center

    Binder, Carl

    2010-01-01

    Precision teaching emerged from O.R. Lindsley's pristine application of Skinner's natural science of behavior, with a focus on response rate measurement and free operant procedures. When applied with human learners in instructional settings, these first principles led to a series of developments framed in this paper as four kinds of ceilings that…

  4. Running demands and heart rate response in rugby union referees.

    PubMed

    Suarez-Arrones, Luis; Portillo, Luis J; García, Jose M; Calvo-Lluch, Africa; Roberts, Simon P; Mendez-Villanueva, Alberto

    2013-11-01

    The aim of this study was to examine the match physical demands and exercise intensity associated with men rugby union refereeing using global positioning system technology. Ten male rugby union referees (age, 37.1 ± 5.9 years; body mass, 83.7 ± 4.8 kg; height, 175.5 ± 6.2 cm) were analyzed 2-4 times during a total of 30 national level matches. The average total distance covered by the referees throughout the game was 6,322.2 ± 564.9 m. As a percentage of total distance, 37.3% (2,356.9 ± 291.3 m) was spent walking, 24.1% (1,524.4 ± 229.4 m) jogging, 10.4% (656.2 ± 130.7 m) running at low intensity, 17.6% (1,110.3 ± 212.2 m) at medium intensity, 5.5% (347.1 ± 27.1 m) at high intensity, and 5.2% (328.1 ± 230.3 m) at sprint. A significant decrease (p < 0.05) in running performance was observed between the first and the second halves in the last 3 speed zones. When the total distance traveled during consecutive 10-minute periods was compared, there was a significantly greater distance covered in the first 10 minutes of the game (876.3 ± 163 m) compared with 50-60 minutes (679.8 ± 117.6 m), 60-70 minutes (713.03 ± 122.3 m), and 70-80 minutes (694.2 ± 125.7 m; all p < 0.05). The average heart rate responses were similar (p > 0.05) in the first (157 ± 7 b · min; 85% HRmax) and second half (155 ± 7 b · min; 84% HRmax). This study provides evidence of reduced high-intensity running toward the end of the game. These findings offer important information to design better training strategies adapted to the requirements and demands of rugby union refereeing.

  5. America's water: Agricultural water demands and the response of groundwater

    NASA Astrophysics Data System (ADS)

    Ho, M.; Parthasarathy, V.; Etienne, E.; Russo, T. A.; Devineni, N.; Lall, U.

    2016-07-01

    Agricultural, industrial, and urban water use in the conterminous United States (CONUS) is highly dependent on groundwater that is largely drawn from nonsurficial wells (>30 m). We use a Demand-Sensitive Drought Index to examine the impacts of agricultural water needs, driven by low precipitation, high agricultural water demand, or a combination of both, on the temporal variability of depth to groundwater across the CONUS. We characterize the relationship between changes in groundwater levels, agricultural water deficits relative to precipitation during the growing season, and winter precipitation. We find that declines in groundwater levels in the High Plains aquifer and around the Mississippi River Valley are driven by groundwater withdrawals used to supplement agricultural water demands. Reductions in agricultural water demands for crops do not, however, lead to immediate recovery of groundwater levels due to the demand for groundwater in other sectors in regions such as Utah, Maryland, and Texas.

  6. Selective responsiveness: Online public demands and government responsiveness in authoritarian China.

    PubMed

    Su, Zheng; Meng, Tianguang

    2016-09-01

    The widespread use of information and communication technology (ICT) has reshaped the public sphere in the digital era, making online forums a new channel for political participation. Using big data analytics of full records of citizen-government interactions from 2008 to early 2014 on a nationwide political forum, we find that authoritarian China is considerably responsive to citizens' demands with a rapid growth of response rate; however, government responsiveness is highly selective, conditioning on actors' social identities and the policy domains of their online demands. Results from logistic and duration models suggest that requests which made by local citizens, expressed collectively, focused on the single task issue, and are closely related to economic growth are more likely to be responded to. These strategies adopted by Chinese provincial leaders reveal the scope and selectivity of authoritarian responsiveness.

  7. Selective responsiveness: Online public demands and government responsiveness in authoritarian China.

    PubMed

    Su, Zheng; Meng, Tianguang

    2016-09-01

    The widespread use of information and communication technology (ICT) has reshaped the public sphere in the digital era, making online forums a new channel for political participation. Using big data analytics of full records of citizen-government interactions from 2008 to early 2014 on a nationwide political forum, we find that authoritarian China is considerably responsive to citizens' demands with a rapid growth of response rate; however, government responsiveness is highly selective, conditioning on actors' social identities and the policy domains of their online demands. Results from logistic and duration models suggest that requests which made by local citizens, expressed collectively, focused on the single task issue, and are closely related to economic growth are more likely to be responded to. These strategies adopted by Chinese provincial leaders reveal the scope and selectivity of authoritarian responsiveness. PMID:27480371

  8. Development and Demonstration of the Open Automated Demand Response Standard for the Residential Sector

    SciTech Connect

    Herter, Karen; Rasin, Josh; Perry, Tim

    2009-11-30

    The goal of this study was to demonstrate a demand response system that can signal nearly every customer in all sectors through the integration of two widely available and non- proprietary communications technologies--Open Automated Demand Response (OpenADR) over lnternet protocol and Utility Messaging Channel (UMC) over FM radio. The outcomes of this project were as follows: (1) a software bridge to allow translation of pricing signals from OpenADR to UMC; and (2) a portable demonstration unit with an lnternet-connected notebook computer, a portfolio of DR-enabling technologies, and a model home. The demonstration unit provides visitors the opportunity to send electricity-pricing information over the lnternet (through OpenADR and UMC) and then watch as the model appliances and lighting respond to the signals. The integration of OpenADR and UMC completed and demonstrated in this study enables utilities to send hourly or sub-hourly electricity pricing information simultaneously to the residential, commercial and industrial sectors.

  9. Estimating Demand Response Market Potential Among Large Commercialand Industrial Customers:A Scoping Study

    SciTech Connect

    Goldman, Charles; Hopper, Nicole; Bharvirkar, Ranjit; Neenan,Bernie; Cappers, Peter

    2007-01-01

    Demand response is increasingly recognized as an essentialingredient to well functioning electricity markets. This growingconsensus was formalized in the Energy Policy Act of 2005 (EPACT), whichestablished demand response as an official policy of the U.S. government,and directed states (and their electric utilities) to considerimplementing demand response, with a particular focus on "price-based"mechanisms. The resulting deliberations, along with a variety of stateand regional demand response initiatives, are raising important policyquestions: for example, How much demand response is enough? How much isavailable? From what sources? At what cost? The purpose of this scopingstudy is to examine analytical techniques and data sources to supportdemand response market assessments that can, in turn, answer the secondand third of these questions. We focus on demand response for large(>350 kW), commercial and industrial (C&I) customers, althoughmany of the concepts could equally be applied to similar programs andtariffs for small commercial and residential customers.

  10. Hawaii demand-side management resource assessment. Final report: DSM opportunity report

    SciTech Connect

    1995-08-01

    The Hawaii Demand-Side Management Resource Assessment was the fourth of seven projects in the Hawaii Energy Strategy (HES) program. HES was designed by the Department of Business, Economic Development, and Tourism (DBEDT) to produce an integrated energy strategy for the State of Hawaii. The purpose of Project 4 was to develop a comprehensive assessment of Hawaii`s demand-side management (DSM) resources. To meet this objective, the project was divided into two phases. The first phase included development of a DSM technology database and the identification of Hawaii commercial building characteristics through on-site audits. These Phase 1 products were then used in Phase 2 to identify expected energy impacts from DSM measures in typical residential and commercial buildings in Hawaii. The building energy simulation model DOE-2.1E was utilized to identify the DSM energy impacts. More detailed information on the typical buildings and the DOE-2.1E modeling effort is available in Reference Volume 1, ``Building Prototype Analysis``. In addition to the DOE-2.1E analysis, estimates of residential and commercial sector gas and electric DSM potential for the four counties of Honolulu, Hawaii, Maui, and Kauai through 2014 were forecasted by the new DBEDT DSM Assessment Model. Results from DBEDTs energy forecasting model, ENERGY 2020, were linked with results from DOE-2.1E building energy simulation runs and estimates of DSM measure impacts, costs, lifetime, and anticipated market penetration rates in the DBEDT DSM Model. Through its algorithms, estimates of DSM potential for each forecast year were developed. Using the load shape information from the DOE-2.1E simulation runs, estimates of electric peak demand impacts were developed. 10 figs., 55 tabs.

  11. Coordination of Retail Demand Response with Midwest ISO Markets

    SciTech Connect

    Bharvirkar, Ranjit; Bharvirkar, Ranjit; Goldman, Charles; Heffner, Grayson; Sedano, Richard

    2008-05-27

    The Organization of Midwest ISO States (OMS) launched the Midwest Demand Resource Initiative (MWDRI) in 2007 to identify barriers to deploying demand response (DR) resources in the Midwest Independent System Operator (MISO) region and develop policies to overcome them. The MWDRI stakeholders decided that a useful initial activity would be to develop more detailed information on existing retail DR programs and dynamic pricing tariffs, program rules, and utility operating practices. This additional detail could then be used to assess any"seams issues" affecting coordination and integration of retail DR resources with MISO's wholesale markets. Working with state regulatory agencies, we conducted a detailed survey of existing DR programs, dynamic pricing tariffs, and their features in MISO states. Utilities were asked to provide information on advance notice requirements to customers, operational triggers used to call events (e.g. system emergencies, market conditions, local emergencies), use of these DR resources to meet planning reserves requirements, DR resource availability (e.g., seasonal, annual), participant incentive structures, and monitoring and verification (M&V) protocols. This report describes the results of this comprehensive survey and discusses policy implications for integrating legacy retail DR programs and dynamic pricing tariffs into organized wholesale markets. Survey responses from 37 MISO members and 4 non-members provided information on 141 DR programs and dynamic pricing tariffs with a peak load reduction potential of 4,727 MW of retail DR resource. Major findings of this study area:- About 72percent of available DR is from interruptible rate tariffs offered to large commercial and industrial customers, while direct load control (DLC) programs account for ~;;18percent. Almost 90percent of the DR resources included in this survey are provided by investor-owned utilities. - Approximately, 90percent of the DR resources are available with less than

  12. Blood pressure responses and incentive appraisals as a function of perceived ability and objective task demand.

    PubMed

    Wright, R A; Dill, J C

    1993-03-01

    This experiment examined the role perceptions of ability may play in determining the impact of task demand on cardiovascular responses indicative of active coping. Subjects first performed a scanning task and received feedback indicating that they had either low or high scanning ability. They then were presented with the opportunity to earn one of two incentives by attaining either an objectively low or objectively high standard of performance on a second scanning task. Immediately prior to and during the 1-min performance period, systolic and diastolic blood pressure responses were greater in the difficult standard condition than in the easy standard condition for those who received high-ability feedback but were somewhat diminished in the difficult standard condition as compared with the easy standard condition for those who received low-ability feedback. Whereas high-ability subjects tended to have less pronounced pressor responses than did low-ability subjects when the second task was objectively easy, they had more pronounced pressor responses than low-ability subjects when the second task was objectively difficult. Analysis of goal attractiveness ratings obtained just prior to task performance showed a general correspondence between subjects' anticipatory blood pressure responses and their appraisals of the incentives. Implications for several lines of investigation are discussed.

  13. Blood pressure responses and incentive appraisals as a function of perceived ability and objective task demand.

    PubMed

    Wright, R A; Dill, J C

    1993-03-01

    This experiment examined the role perceptions of ability may play in determining the impact of task demand on cardiovascular responses indicative of active coping. Subjects first performed a scanning task and received feedback indicating that they had either low or high scanning ability. They then were presented with the opportunity to earn one of two incentives by attaining either an objectively low or objectively high standard of performance on a second scanning task. Immediately prior to and during the 1-min performance period, systolic and diastolic blood pressure responses were greater in the difficult standard condition than in the easy standard condition for those who received high-ability feedback but were somewhat diminished in the difficult standard condition as compared with the easy standard condition for those who received low-ability feedback. Whereas high-ability subjects tended to have less pronounced pressor responses than did low-ability subjects when the second task was objectively easy, they had more pronounced pressor responses than low-ability subjects when the second task was objectively difficult. Analysis of goal attractiveness ratings obtained just prior to task performance showed a general correspondence between subjects' anticipatory blood pressure responses and their appraisals of the incentives. Implications for several lines of investigation are discussed. PMID:8434078

  14. 10 CFR 9.203 - Procedure where response to demand is required prior to receiving instructions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... or Disclosure in Response to Subpoenas or Demands of Courts or Other Authorities § 9.203 Procedure... demand has been made, and shall furnish the court or other authority with a copy of the regulations contained in this subpart and inform the court or other authority that the demand has been, or is being,...

  15. Meeting multiple demands: Water transaction opportunities for environmental benefits promoting adaptation to climate change

    NASA Astrophysics Data System (ADS)

    McCoy, Amy

    2015-04-01

    In arid regions, the challenge of balancing water use among a diversity of sectors expands in lock step with conditions of water stress that are exacerbated by climate variability, prolonged drought, and growing water-use demands. The elusiveness of achieving a sustainable balance under conditions of environmental change in the southwestern United States is evidenced by reductions in both overall water availability and freshwater ecosystem health, as well as by recent projections of shortages on the Colorado River within the next five years. The water sustainability challenge in this region, as well as drylands throughout the world, can therefore be viewed through the lens of water stress, a condition wherein demands on land and water -- including the needs of freshwater ecosystems -- exceed reliable supplies, and the full range of water needs cannot be met without tradeoffs across multiple uses. Water stress influences not only ecosystems, but a region's economy, land management, quality of life, and cultural heritage -- each of which requires water to thrive. With respect to promoting successful adaptation to climate change, achieving full water sustainability would allow for water to be successfully divided among water users -- including municipalities, agriculture, and freshwater ecosystems -- at a level that meets the goals of water users and the governing body. Over the last ten to fifteen years, the use of transactional approaches in the western U.S., Mexico, and Australia has proven to be a viable management tool for achieving stream flow and shallow aquifer restoration. By broad definition, environmental water transactions are an equitable and adaptable tool that brings diverse stakeholders to the table to facilitate a fair-market exchange of rights to use water in a manner that benefits both water users and the environment. This talk will present a basic framework of necessary stakeholder engagement, hydrologic conditions, enabling laws and policies

  16. The Response of Abortion Demand to Changes in Abortion Costs

    ERIC Educational Resources Information Center

    Medoff, Marshall H.

    2008-01-01

    This study uses pooled cross-section time-series data, over the years 1982, 1992 and 2000, to estimate the impact of various restrictive abortion laws on the demand for abortion. This study complements and extends prior research by explicitly including the price of obtaining an abortion in the estimation. The empirical results show that the real…

  17. Drivers for the Value of Demand Response under Increased Levels of Wind and Solar Power; NREL (National Renewable Energy Laboratory)

    SciTech Connect

    Hale, Elaine

    2015-07-30

    Demand response may be a valuable flexible resource for low-carbon electric power grids. However, there are as many types of possible demand response as there are ways to use electricity, making demand response difficult to study at scale in realistic settings. This talk reviews our state of knowledge regarding the potential value of demand response in several example systems as a function of increasing levels of wind and solar power, sometimes drawing on the analogy between demand response and storage. Overall, we find demand response to be promising, but its potential value is very system dependent. Furthermore, demand response, like storage, can easily saturate ancillary service markets.

  18. 75 FR 15362 - Demand Response Compensation in Organized Wholesale Energy Markets

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... market price for energy for such reductions.\\4\\ \\1\\ Demand response means a reduction in the consumption... price of electric energy or to incentive payments designed to induce lower consumption of electric... decline of six to 12 percent.\\10\\ Demand response can also lower prices in the organized wholesale...

  19. 75 FR 54063 - Demand Response Compensation in Organized Wholesale Energy Markets; Technical Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ...\\ Demand Response Compensation in Organized Wholesale Energy Markets, Notice of Proposed Rulemaking, 75 FR... Rulemaking and Notice of Technical Conference (Supplemental Notice), 75 FR 47,499, 132 FERC ] 61,094 (issued... COMMISSION 18 CFR Part 35 Demand Response Compensation in Organized Wholesale Energy Markets;...

  20. 12 CFR 1703.40 - Responses to demands served on nonemployees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Responses to demands served on nonemployees... Production of Documents in Legal Proceedings in Which OFHEO Is Not a Named Party § 1703.40 Responses to demands served on nonemployees. (a) OFHEO reports of examinations, or any documents related thereto,...

  1. Physical demands and physiological responses during elite field hockey.

    PubMed

    Lythe, J; Kilding, A E

    2011-07-01

    The aim of this study was to determine the physical demands of elite men's field hockey using modern time-motion analysis techniques. 18 elite male players (age: 24.4 ± 4.5 yrs) participated in 5 matches, during which physical outputs of players were quantified using GPS units and heart rate monitors. The mean total distance covered by each individual player was 6798 ± 2009 m. Mean total distance covered per position for 70 min (position (70)) was 8160 ± 428 m. Distance covered per position (70) decreased by 4.8% between the 1 (st )and 2 (nd) halves ( P < 0.05). Fullbacks covered significantly less total distance than all other positions ( P < 0.05). High-intensity running (>19 km.h (-1)) comprised 6.1% (479 ± 108 m) of the total distance covered and involved 34 ± 12 sprints per player, with an average duration of 3.3 s. Average HR was higher in the 1 (st) half (86.7% HR (max)) than the 2 (nd) half, (84.4% HR (max)), though this was not significant ( P = 0.06). The results suggest that modern day elite field hockey is a physically demanding team sport. Quantification of the demands and outputs of players at this level provides a useful framework on which to develop conditioning practices. The difference in physical outputs observed for some positions suggests position-specific conditioning is required at the elite level. PMID:21563026

  2. Examining Uncertainty in Demand Response Baseline Models and Variability in Automated Response to Dynamic Pricing

    SciTech Connect

    Mathieu, Johanna L.; Callaway, Duncan S.; Kiliccote, Sila

    2011-08-15

    Controlling electric loads to deliver power system services presents a number of interesting challenges. For example, changes in electricity consumption of Commercial and Industrial (C&I) facilities are usually estimated using counterfactual baseline models, and model uncertainty makes it difficult to precisely quantify control responsiveness. Moreover, C&I facilities exhibit variability in their response. This paper seeks to understand baseline model error and demand-side variability in responses to open-loop control signals (i.e. dynamic prices). Using a regression-based baseline model, we define several Demand Response (DR) parameters, which characterize changes in electricity use on DR days, and then present a method for computing the error associated with DR parameter estimates. In addition to analyzing the magnitude of DR parameter error, we develop a metric to determine how much observed DR parameter variability is attributable to real event-to-event variability versus simply baseline model error. Using data from 38 C&I facilities that participated in an automated DR program in California, we find that DR parameter errors are large. For most facilities, observed DR parameter variability is likely explained by baseline model error, not real DR parameter variability; however, a number of facilities exhibit real DR parameter variability. In some cases, the aggregate population of C&I facilities exhibits real DR parameter variability, resulting in implications for the system operator with respect to both resource planning and system stability.

  3. Chilled Water Thermal Storage System and Demand Response at the University of California at Merced

    SciTech Connect

    Granderson, Jessica; Dudley, Junqiao Han; Kiliccote, Sila; Piette, Mary Ann

    2009-10-08

    The University of California at Merced is a unique campus that has benefited from intensive efforts to maximize energy efficiency, and has participated in a demand response program for the past two years. Campus demand response evaluations are often difficult because of the complexities introduced by central heating and cooling, non-coincident and diverse building loads, and existence of a single electrical meter for the entire campus. At the University of California at Merced, a two million gallon chilled water storage system is charged daily during off-peak price periods and used to flatten the load profile during peak demand periods. This makes demand response more subtle and challenges typical evaluation protocols. The goal of this research is to study demand response savings in the presence of storage systems in a campus setting. First, University of California at Merced summer electric loads are characterized; second, its participation in two demand response events is detailed. In each event a set of strategies were pre-programmed into the campus control system to enable semi-automated response. Finally, demand savings results are applied to the utility's DR incentives structure to calculate the financial savings under various DR programs and tariffs. A key conclusion to this research is that there is significant demand reduction using a zone temperature set point change event with the full off peak storage cooling in use.

  4. Assessing the Control Systems Capacity for Demand Response in California Industries

    SciTech Connect

    Ghatikar, Girish; McKane, Aimee; Goli, Sasank; Therkelsen, Peter; Olsen, Daniel

    2012-01-18

    California's electricity markets are moving toward dynamic pricing models, such as real-time pricing, within the next few years, which could have a significant impact on an industrial facility's cost of energy use during the times of peak use. Adequate controls and automated systems that provide industrial facility managers real-time energy use and cost information are necessary for successful implementation of a comprehensive electricity strategy; however, little is known about the current control capacity of California industries. To address this gap, Lawrence Berkeley National Laboratory, in close collaboration with California industrial trade associations, conducted a survey to determine the current state of controls technologies in California industries. This,study identifies sectors that have the technical capability to implement Demand Response (DR) and Automated Demand Response (Auto-DR). In an effort to assist policy makers and industry in meeting the challenges of real-time pricing, facility operational and organizational factors were taken into consideration to generate recommendations on which sectors Demand Response efforts should be focused. Analysis of the survey responses showed that while the vast majority of industrial facilities have semi- or fully automated control systems, participation in Demand Response programs is still low due to perceived barriers. The results also showed that the facilities that use continuous processes are good Demand Response candidates. When comparing facilities participating in Demand Response to those not participating, several similarities and differences emerged. Demand Response-participating facilities and non-participating facilities had similar timings of peak energy use, production processes, and participation in energy audits. Though the survey sample was smaller than anticipated, the results seemed to support our preliminary assumptions. Demonstrations of Auto-Demand Response in industrial facilities with

  5. Reducing Demand through Efficiency and Services: Impacts and Opportunities in Buildings Sector (Carbon Cycle 2.0)

    ScienceCinema

    Piette, Mary Ann [Director, Demand Response Research Center

    2016-07-12

    Mary Ann Piette, Deputy of LBNL's Building Technologies Department and Director of the Demand Response Research Center, speaks at the Carbon Cycle 2.0 kick-off symposium Feb. 2, 2010. We emit more carbon into the atmosphere than natural processes are able to remove - an imbalance with negative consequences. Carbon Cycle 2.0 is a Berkeley Lab initiative to provide the science needed to restore this balance by integrating the Labs diverse research activities and delivering creative solutions toward a carbon-neutral energy future. http://carboncycle2.lbl.gov/

  6. Reducing Demand through Efficiency and Services: Impacts and Opportunities in Buildings Sector (Carbon Cycle 2.0)

    SciTech Connect

    Piette, Mary Ann

    2010-02-02

    Mary Ann Piette, Deputy of LBNL's Building Technologies Department and Director of the Demand Response Research Center, speaks at the Carbon Cycle 2.0 kick-off symposium Feb. 2, 2010. We emit more carbon into the atmosphere than natural processes are able to remove - an imbalance with negative consequences. Carbon Cycle 2.0 is a Berkeley Lab initiative to provide the science needed to restore this balance by integrating the Labs diverse research activities and delivering creative solutions toward a carbon-neutral energy future. http://carboncycle2.lbl.gov/

  7. Agricultural sectoral demand and crop productivity response across the world

    NASA Astrophysics Data System (ADS)

    Johnston, M.; Ray, D. K.; Cassidy, E. S.; Foley, J. A.

    2013-12-01

    With an increasing and increasingly affluent population, humans will need to roughly double agricultural production by 2050. Continued yield growth forms the foundation of all future strategies aiming to increase agricultural production while slowing or eliminating cropland expansion. However, a recent analysis by one of our co-authors has shown that yield trends in many important maize, wheat and rice growing regions have begun stagnating or declining from the highs seen during the green revolution (Ray et al. 2013). Additional research by our group has shown that nearly 50% of new agricultural production since the 1960s has gone not to direct human consumption, but instead to animal feed and other industrial uses. Our analysis for GLP looks at the convergence of these two trends by examining time series utilization data for 16 of the biggest crops to determine how demand from different sectors has shaped our land-use and intensification strategies around the world. Before rushing headlong into the next agricultural doubling, it would be prudent to first consult our recent agricultural history to better understand what was driving past changes in production. Using newly developed time series dataset - a fusion of cropland maps with historic agricultural census data gathered from around the world - we can examine yield and harvested area trends over the last half century for 16 top crops. We combine this data with utilization rates from the FAO Food Balance Sheet to see how demand from different sectors - food, feed, and other - has influenced long-term growth trends from the green revolution forward. We will show how intensification trends over time and across regions have grown or contracted depending on what is driving the change in production capacity. Ray DK, Mueller ND, West PC, Foley JA (2013) Yield Trends Are Insufficient to Double Global Crop Production by 2050. PLoS ONE 8(6): e66428. doi:10.1371/journal.pone.0066428

  8. Detecting biological responses to flow management: Missed opportunities; future directions

    USGS Publications Warehouse

    Souchon, Y.; Sabaton, C.; Deibel, R.; Reiser, D.; Kershner, J.; Gard, M.; Katopodis, C.; Leonard, P.; Poff, N.L.; Miller, W.J.; Lamb, B.L.

    2008-01-01

    The conclusions of numerous stream restoration assessments all around the world are extremely clear and convergent: there has been insufficient appropriate monitoring to improve general knowledge and expertise. In the specialized field of instream flow alterations, we consider that there are several opportunities comparable to full-size experiments. Hundreds of water management decisions related to instream flow releases have been made by government agencies, native peoples, and non-governmental organizations around the world. These decisions are based on different methods and assumptions and many flow regimes have been adopted by formal or informal rules and regulations. Although, there have been significant advances in analytical capabilities, there has been very little validation monitoring of actual outcomes or research related to the response of aquatic dependent species to new flow regimes. In order to be able to detect these kinds of responses and to better guide decision, a general design template is proposed. The main steps of this template are described and discussed, in terms of objectives, hypotheses, variables, time scale, data management, and information, in the spirit of adaptive management. The adoption of such a framework is not always easy, due to differing interests of actors for the results, regarding the duration of monitoring, nature of funding and differential timetables between facilities managers and technicians. Nevertheless, implementation of such a framework could help researchers and practitioners to coordinate and federate their efforts to improve the general knowledge of the links between the habitat dynamics and biological aquatic responses. Copyright ?? 2008 John Wiley & Sons, Ltd.

  9. Automation of Capacity Bidding with an Aggregator Using Open Automated Demand Response

    SciTech Connect

    Kiliccote, Sila; Piette, Mary Ann

    2008-10-01

    This report summarizes San Diego Gas& Electric Company?s collaboration with the Demand Response Research Center to develop and test automation capability for the Capacity Bidding Program in 2007. The report describes the Open Automated Demand Response architecture, summarizes the history of technology development and pilot studies. It also outlines the Capacity Bidding Program and technology being used by an aggregator that participated in this demand response program. Due to delays, the program was not fully operational for summer 2007. However, a test event on October 3, 2007, showed that the project successfully achieved the objective to develop and demonstrate how an open, Web?based interoperable automated notification system for capacity bidding can be used by aggregators for demand response. The system was effective in initiating a fully automated demand response shed at the aggregated sites. This project also demonstrated how aggregators can integrate their demand response automation systems with San Diego Gas& Electric Company?s Demand Response Automation Server and capacity bidding program.

  10. Relationship-Based Infant Care: Responsive, on Demand, and Predictable

    ERIC Educational Resources Information Center

    Petersen, Sandra; Wittmer, Donna

    2008-01-01

    Young babies are easily overwhelmed by the pain of hunger or gas. However, when an infant's day is filled with caregiving experiences characterized by quick responses to his cries and accurate interpretations of the meaning of his communication, the baby learns that he can count on being fed and comforted. He begins to develop trust in his teacher…

  11. 49 CFR 37.189 - Service requirement for OTRB demand-responsive systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... business of transporting people, whose operations affect commerce, and that provide demand-responsive OTRB... normal reservation policies or to displace another passenger who has reserved a seat on the bus....

  12. 78 FR 38023 - Demand Response Supporters v. New York Independent System Operator, Inc.; Notice of Complaint

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Demand Response Supporters v. New York Independent System Operator, Inc... against New York Independent System Operator, Inc. (NYISO or Respondents), seeking an order...

  13. Design and Implementation of an Open, Interoperable AutomatedDemand Response Infrastructure

    SciTech Connect

    Piette, Mary Ann; Kiliccote, Sila; Ghatikar, Girish

    2007-10-01

    This paper describes the concept for and lessons from the development and field-testing of an open, interoperable communications infrastructure to support automating demand response (DR). Automating DR allows greater levels of participation and improved reliability and repeatability of the demand response and customer facilities. Automated DR systems have been deployed for critical peak pricing and demand bidding and are being designed for real time pricing. The system is designed to generate, manage, and track DR signals between utilities and Independent System Operators (ISOs) to aggregators and end-use customers and their control systems.

  14. Field Test Results of Automated Demand Response in a Large Office Building

    SciTech Connect

    Han, Junqiao; Piette, Mary Ann; Kiliccote, Sila

    2008-10-20

    Demand response (DR) is an emerging research field and an effective tool that improves grid reliability and prevents the price of electricity from rising, especially in deregulated markets. This paper introduces the definition of DR and Automated Demand Response (Auto-DR). It describes the Auto-DR technology utilized at a commercial building in the summer of 2006 and the methodologies to evaluate associated demand savings. On the basis of field tests in a large office building, Auto-DR is proven to be a reliable and credible resource that ensures a stable and economical operation of the power grid.

  15. Challenges and Opportunities in Geocuration for Disaster Response

    NASA Astrophysics Data System (ADS)

    Molthan, A.; Burks, J. E.; McGrath, K.; Ramachandran, R.; Goodman, H. M.

    2015-12-01

    Following a significant disaster event, a wide range of resources and science teams are leveraged to aid in the response effort. Often, these efforts include the acquisition and use of non-traditional data sets, or the generation of prototyped products using new image analysis techniques. These efforts may also include acquisition and hosting of remote sensing data sets from domestic and international partners - from the public or private sector - which differ from standard remote sensing holdings, or may be accompanied by specific licensing agreements that limit their use and dissemination. In addition, at time periods well beyond the initial disaster event, other science teams may incorporate airborne or field campaign measurements that support the assessment of damage but also acquire information necessary to address key science questions about the specific disaster or a broader category of similar events. The immediate need to gather data and provide information to the response effort can result in large data holdings that require detailed curation to improve the efficiency of response efforts, but also ensure that collected data can be used on a longer time scale to address underlying science questions. Data collected in response to a disaster event may be thought of as a "field campaign" - consisting of traditional data sets managed through physical or virtual holdings, but also a larger number of ad hoc data collections, derived products, and metadata, including the potential for airborne or ground-based data collections. Appropriate metadata and documentation are needed to ensure that derived products have traceability to their source data, along with documentation of algorithm authors, versions, and outcomes so that others can reproduce their results, and to ensure that data sets remain available and well-documented for longer-term analysis that may in turn create new products relevant to understanding a type of disaster, or support future recovery efforts

  16. Reflections on the Opportunities and Challenges of Disaster Response

    ERIC Educational Resources Information Center

    Juntunen, Cindy L.

    2011-01-01

    This reaction article applauds the authors of the Major Contribution for their thoughtful and thorough consideration of the myriad issues that accompany disaster mental health work. The reaction highlights three themes that emerged in the articles of the contribution: opportunities for collaboration, opportunities for the application of social…

  17. The Role of Demand Response in Reducing Water-Related Power Plant Vulnerabilities

    NASA Astrophysics Data System (ADS)

    Macknick, J.; Brinkman, G.; Zhou, E.; O'Connell, M.; Newmark, R. L.; Miara, A.; Cohen, S. M.

    2015-12-01

    The electric sector depends on readily available water supplies for reliable and efficient operation. Elevated water temperatures or low water levels can trigger regulatory or plant-level decisions to curtail power generation, which can affect system cost and reliability. In the past decade, dozens of power plants in the U.S. have curtailed generation due to water temperatures and water shortages. Curtailments occur during the summer, when temperatures are highest and there is greatest demand for electricity. Climate change could alter the availability and temperature of water resources, exacerbating these issues. Constructing alternative cooling systems to address vulnerabilities can be capital intensive and can also affect power plant efficiencies. Demand response programs are being implemented by electric system planners and operators to reduce and shift electricity demands from peak usage periods to other times of the day. Demand response programs can also play a role in reducing water-related power sector vulnerabilities during summer months. Traditionally, production cost modeling and demand response analyses do not include water resources. In this effort, we integrate an electricity production cost modeling framework with water-related impacts on power plants in a test system to evaluate the impacts of demand response measures on power system costs and reliability. Specifically, we i) quantify the cost and reliability implications of incorporating water resources into production cost modeling, ii) evaluate the impacts of demand response measures on reducing system costs and vulnerabilities, and iii) consider sensitivity analyses with cooling systems to highlight a range of potential benefits of demand response measures. Impacts from climate change on power plant performance and water resources are discussed. Results provide key insights to policymakers and practitioners for reducing water-related power plant vulnerabilities via lower cost methods.

  18. 36 CFR 1251.4 - May employees provide records or give testimony in response to a demand without authorization?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... or give testimony in response to a demand without authorization? 1251.4 Section 1251.4 Parks, Forests... § 1251.4 May employees provide records or give testimony in response to a demand without authorization... information or provide any testimony relating to agency information in response to a demand, or other...

  19. 28 CFR 42.3 - Responsibility for Department of Justice Equal Opportunity Recruitment Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Equal Opportunity Recruitment Program. 42.3 Section 42.3 Judicial Administration DEPARTMENT OF JUSTICE... Department of Justice § 42.3 Responsibility for Department of Justice Equal Opportunity Recruitment Program... implementing the Department of Justice Equal Opportunity Recruitment Program under 5 U.S.C. 7201....

  20. 28 CFR 42.3 - Responsibility for Department of Justice Equal Opportunity Recruitment Program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Responsibility for Department of Justice Equal Opportunity Recruitment Program. 42.3 Section 42.3 Judicial Administration DEPARTMENT OF JUSTICE... Department of Justice § 42.3 Responsibility for Department of Justice Equal Opportunity Recruitment...

  1. 28 CFR 42.3 - Responsibility for Department of Justice Equal Opportunity Recruitment Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Responsibility for Department of Justice Equal Opportunity Recruitment Program. 42.3 Section 42.3 Judicial Administration DEPARTMENT OF JUSTICE... Department of Justice § 42.3 Responsibility for Department of Justice Equal Opportunity Recruitment...

  2. 28 CFR 42.3 - Responsibility for Department of Justice Equal Opportunity Recruitment Program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Responsibility for Department of Justice Equal Opportunity Recruitment Program. 42.3 Section 42.3 Judicial Administration DEPARTMENT OF JUSTICE... Department of Justice § 42.3 Responsibility for Department of Justice Equal Opportunity Recruitment...

  3. Aggregated Modeling of Thermostatic Loads in Demand Response: A Systems and Control Perspective

    SciTech Connect

    Kalsi, Karanjit; Chassin, Forrest S.; Chassin, David P.

    2011-12-12

    Demand response is playing an increasingly important role in smart grid research and technologies being examined in recently undertaken demonstration projects. The behavior of load as it is affected by various load control strategies is important to understanding the degree to which different classes of end-use load can contribute to demand response programs at various times. This paper focuses on developing aggregated models for a homogeneous population of thermostatically controlled loads. The different types of loads considered in this paper include, but are not limited to, water heaters and HVAC units. The effects of demand response and user over-ride on the load population dynamics are investigated. The controllability of the developed lumped models is validated which forms the basis for designing different control strategies.

  4. Price Responsive Demand in New York Wholesale Electricity Market using OpenADR

    SciTech Connect

    Kim, Joyce Jihyun; Kiliccote, Sila

    2012-06-01

    In New York State, the default electricity pricing for large customers is Mandatory Hourly Pricing (MHP), which is charged based on zonal day-ahead market price for energy. With MHP, retail customers can adjust their building load to an economically optimal level according to hourly electricity prices. Yet, many customers seek alternative pricing options such as fixed rates through retail access for their electricity supply. Open Automated Demand Response (OpenADR) is an XML (eXtensible Markup Language) based information exchange model that communicates price and reliability information. It allows customers to evaluate hourly prices and provide demand response in an automated fashion to minimize electricity costs. This document shows how OpenADR can support MHP and facilitate price responsive demand for large commercial customers in New York City.

  5. AMI Communication Requirements to Implement Demand-Response: Applicability of Hybrid Spread Spectrum Wireless

    SciTech Connect

    Hadley, Mark D.; Clements, Samuel L.; Carroll, Thomas E.

    2011-09-30

    While holistically defining the smart grid is a challenge, one area of interest is demand-response. In 2009, the Department of Energy announced over $4 billion in grant and project funding for the Smart Grid. A significant amount of this funding was allotted to utilities for cost sharing projects to deploy Smart Grid technologies, many of whom have deployed and are deploying advanced metering infrastructure (AMI). AMI is an enabler to increase the efficiency of utilities and the bulk power grid. The bulk electrical system is unique in that it produces electricity as it is consumed. Most other industries have a delay between generation and consumption. This aspect of the power grid means that there must be enough generation capacity to meet the highest demand whereas other industries could over produce during off-peak times. This requires significant investment in generation capacity to cover the few days a year of peak consumption. Since bulk electrical storage doesn't yet exist at scale another way to curb the need for new peak period generation is through demand-response; that is to incentivize consumers (demand) to curtail (respond) electrical usage during peak periods. Of the various methods proposed for enabling demand-response, this paper will focus on the communication requirements for creating an energy market using transactional controls. More specifically, the paper will focus on the communication requirements needed to send the peak period notices and receive the response back from the consumers.

  6. Demand response pilot event conducted August 2,2011 : summary report.

    SciTech Connect

    Lincoln, Donald; Evans, Christoper

    2012-01-01

    Energy management in a commercial facility can be segregated into two areas: energy efficiency and demand response (DR). Energy efficiency focuses on steady-state load minimization. Demand response reduces load for event driven periods during the peak load. Demand-response-driven changes in electricity use are designed to be short-term in nature, centered on critical hours during the day when demand is high or when the electricity supplier's reserve margins are low. Due to the recent Federal Energy Regulatory Commission (FERC) Order 745, Demand Response Compensation in Organized Wholesale Energy Markets the potential annual compensation to Sandia National Laboratories (SNL) from performing DR ranges from $300K to $2,400K. While the current energy supply contract does not offer any compensation for participating in DR, there is benefit in understanding the issues and potential value in performing a DR event. This Report will be helpful in upcoming energy supply contract negotiations to quantify the energy savings and power reduction potential from DR at SNL. On August 25, 2011 the Facilities Management and Operations Center (FMOC) performed the first DR pilot event at SNL/NM. This report describes the details and results of this DR event.

  7. Using high frequency consumption data to identify demand response potential for solar energy integration

    NASA Astrophysics Data System (ADS)

    Jin, L.; Borgeson, S.; Fredman, D.; Hans, L.; Spurlock, A.; Todd, A.

    2015-12-01

    California's renewable portfolio standard (2012) requires the state to get 33% of its electricity from renewable sources by 2020. Increased share of variable renewable sources such as solar and wind in the California electricity system may require more grid flexibility to insure reliable power services. Such grid flexibility can be potentially provided by changes in end use electricity consumptions in response to grid conditions (demand-response). In the solar case, residential consumption in the late afternoon can be used as reserve capacity to balance the drop in solar generation. This study presents our initial attempt to identify, from a behavior perspective, residential demand response potentials in relation to solar ramp events using a data-driven approach. Based on hourly residential energy consumption data, we derive representative daily load shapes focusing on discretionary consumption with an innovative clustering analysis technique. We aggregate the representative load shapes into behavior groups in terms of the timing and rhythm of energy use in the context of solar ramp events. Households of different behavior groups that are active during hours with high solar ramp rates are identified for capturing demand response potential. Insights into the nature and predictability of response to demand-response programs are provided.

  8. Architecture Concepts and Technical Issues for an Open,Interoperable Automated Demand Response Infrastructure

    SciTech Connect

    Koch, Ed; Piette, Mary Ann

    2007-10-01

    This paper presents the technical and architectural issues associated with automating Demand Response (DR) programs. The paper focuses on a description of the Demand Response Automation Server (DRAS), which is the main component used to automate the interactions between the Utilities and their customers for DR programs. Use cases are presented that show the role of the DRAS in automating various aspects of DR programs. This paper also describes the various technical aspects of the DRAS including its interfaces and major modes of operation. This includes how the DRAS supports automating such Utility/Customer interactions as automated DR bidding, automated DR event handling, and finally real-time pricing.

  9. Perceptual demand modulates activation of human auditory cortex in response to task-irrelevant sounds.

    PubMed

    Sabri, Merav; Humphries, Colin; Verber, Matthew; Mangalathu, Jain; Desai, Anjali; Binder, Jeffrey R; Liebenthal, Einat

    2013-09-01

    In the visual modality, perceptual demand on a goal-directed task has been shown to modulate the extent to which irrelevant information can be disregarded at a sensory-perceptual stage of processing. In the auditory modality, the effect of perceptual demand on neural representations of task-irrelevant sounds is unclear. We compared simultaneous ERPs and fMRI responses associated with task-irrelevant sounds across parametrically modulated perceptual task demands in a dichotic-listening paradigm. Participants performed a signal detection task in one ear (Attend ear) while ignoring task-irrelevant syllable sounds in the other ear (Ignore ear). Results revealed modulation of syllable processing by auditory perceptual demand in an ROI in middle left superior temporal gyrus and in negative ERP activity 130-230 msec post stimulus onset. Increasing the perceptual demand in the Attend ear was associated with a reduced neural response in both fMRI and ERP to task-irrelevant sounds. These findings are in support of a selection model whereby ongoing perceptual demands modulate task-irrelevant sound processing in auditory cortex.

  10. Reduced-Order Modeling of Aggregated Thermostatic Loads With Demand Response

    SciTech Connect

    Zhang, Wei; Lian, Jianming; Chang, Chin-Yao; Kalsi, Karanjit; Sun, Yannan

    2012-12-12

    Demand Response is playing an increasingly important role in smart grid control strategies. Modeling the behavior of populations of appliances under demand response is especially important to evaluate the effectiveness of these demand response programs. In this paper, an aggregated model is proposed for a class of Thermostatically Controlled Loads (TCLs). The model efficiently includes statistical information of the population, systematically deals with heterogeneity, and accounts for a second-order effect necessary to accurately capture the transient dynamics in the collective response. However, an accurate characterization of the collective dynamics however requires the aggregate model to have a high state space dimension. Most of the existing model reduction techniques require the stability of the underlying system which does not hold for the proposed aggregated model. In this work, a novel model reduction approach is developed for the proposed aggregated model, which can significantly reduce its complexity with small performance loss. The original and the reducedorder aggregated models are validated against simulations of thousands of detailed building models using GridLAB-D, which is a realistic open source distribution simulation software. Index Terms – demand response, aggregated model, ancillary

  11. Development and evaluation of fully automated demand response in large facilities

    SciTech Connect

    Piette, Mary Ann; Sezgen, Osman; Watson, David S.; Motegi, Naoya; Shockman, Christine; ten Hope, Laurie

    2004-03-30

    This report describes the results of a research project to develop and evaluate the performance of new Automated Demand Response (Auto-DR) hardware and software technology in large facilities. Demand Response (DR) is a set of activities to reduce or shift electricity use to improve electric grid reliability, manage electricity costs, and ensure that customers receive signals that encourage load reduction during times when the electric grid is near its capacity. The two main drivers for widespread demand responsiveness are the prevention of future electricity crises and the reduction of electricity prices. Additional goals for price responsiveness include equity through cost of service pricing, and customer control of electricity usage and bills. The technology developed and evaluated in this report could be used to support numerous forms of DR programs and tariffs. For the purpose of this report, we have defined three levels of Demand Response automation. Manual Demand Response involves manually turning off lights or equipment; this can be a labor-intensive approach. Semi-Automated Response involves the use of building energy management control systems for load shedding, where a preprogrammed load shedding strategy is initiated by facilities staff. Fully-Automated Demand Response is initiated at a building or facility through receipt of an external communications signal--facility staff set up a pre-programmed load shedding strategy which is automatically initiated by the system without the need for human intervention. We have defined this approach to be Auto-DR. An important concept in Auto-DR is that a facility manager is able to ''opt out'' or ''override'' an individual DR event if it occurs at a time when the reduction in end-use services is not desirable. This project sought to improve the feasibility and nature of Auto-DR strategies in large facilities. The research focused on technology development, testing, characterization, and evaluation relating to Auto

  12. Automated Price and Demand Response Demonstration for Large Customers in New York City using OpenADR

    SciTech Connect

    Kim, Joyce Jihyun; Yin, Rongxin; Kiliccote, Sila

    2013-10-01

    Open Automated Demand Response (OpenADR), an XML-based information exchange model, is used to facilitate continuous price-responsive operation and demand response participation for large commercial buildings in New York who are subject to the default day-ahead hourly pricing. We summarize the existing demand response programs in New York and discuss OpenADR communication, prioritization of demand response signals, and control methods. Building energy simulation models are developed and field tests are conducted to evaluate continuous energy management and demand response capabilities of two commercial buildings in New York City. Preliminary results reveal that providing machine-readable prices to commercial buildings can facilitate both demand response participation and continuous energy cost savings. Hence, efforts should be made to develop more sophisticated algorithms for building control systems to minimize customer's utility bill based on price and reliability information from the electricity grid.

  13. Universities Response to Oil and Gas Industry Demands in South Texas (USA) and Tamaulipas (Mexico)

    ERIC Educational Resources Information Center

    Navarro, Marco Aurelio

    2016-01-01

    Given the importance of hydrocarbons for this area, the purpose of this paper is to explore the response of universities to cope with new demands in the south of Texas and Tamaulipas, especially in relation to gas plays of Eagle Ford (Texas side) and Burgos Basin (Mexican side). To accomplish this task, in the first section of the paper a broad…

  14. Near infrared light-responsive and injectable supramolecular hydrogels for on-demand drug delivery.

    PubMed

    Wang, Xinyu; Wang, Changping; Zhang, Qiang; Cheng, Yiyun

    2016-01-18

    A near infrared (NIR) light-responsive supramolecular hydrogel consisting of α-cyclodextrin and poly(ethylene glycol)-modified dendrimer-encapsulated platinum nanoparticles was developed. Upon NIR irradiation, this hydrogel underwent a photothermo-sensitive degradation to release the entrapped therapeutic agents in an on-demand and dose-tunable fashion. PMID:26588349

  15. 49 CFR 37.189 - Service requirement for OTRB demand-responsive systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... systems. 37.189 Section 37.189 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.189 Service requirement for OTRB demand-responsive systems. (a) This section applies to private entities primarily in...

  16. 78 FR 21928 - Demand Response Coalition v. PJM Interconnection, L.L.C.; Notice of Complaint

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Demand Response Coalition v. PJM Interconnection, L.L.C.; Notice of... formal complaint against the PJM Interconnection, L.L.C. (Respondent or PJM), alleging that certain...

  17. APPARATUS FOR CONTROL OF A BOILING REACTOR RESPONSIVE TO STEAM DEMAND

    DOEpatents

    Treshow, M.

    1963-07-23

    A method of controlling a fuel-rod-in-tube-type boilingwater reactor having nozzles at the point of water entry into the tube is described. Water is pumped into the nozzles by an auxiliary pump operated by steam from an interstage position of the associated turbine, so that the pumping speed is responsive to turbine demand. (AEC)

  18. Demands on Attention and the Role of Response Priming in Visual Discrimination of Feature Conjunctions

    ERIC Educational Resources Information Center

    Fournier, Lisa R.; Herbert, Rhonda J.; Farris, Carrie

    2004-01-01

    This study examined how response mapping of features within single- and multiple-feature targets affects decision-based processing and attentional capacity demands. Observers judged the presence or absence of 1 or 2 target features within an object either presented alone or with distractors. Judging the presence of 2 features relative to the less…

  19. 49 CFR 37.189 - Service requirement for OTRB demand-responsive systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.189 Service requirement... to purchase or lease accessible buses in connection with providing demand-responsive service. (b... normal reservation policies or to displace another passenger who has reserved a seat on the bus....

  20. 49 CFR 37.189 - Service requirement for OTRB demand-responsive systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.189 Service requirement... to purchase or lease accessible buses in connection with providing demand-responsive service. (b... normal reservation policies or to displace another passenger who has reserved a seat on the bus....

  1. Increasing Opportunities for Student Responding: Response Cards in the Classroom

    ERIC Educational Resources Information Center

    Helf, Shawnna

    2015-01-01

    Response cards are designed to encourage active student engagement during instruction. In this article, the use of response cards is described, along with ways teachers can use the information to inform their work and considerations for implementation.

  2. A future Demand Side Management (DSM) opportunity for utility as variable renewable penetrate scale up using agriculture.

    NASA Astrophysics Data System (ADS)

    Ines, A.; Bhattacharjee, A.; Modi, V.; Robertson, A. W.; Lall, U.; Kocaman Ayse, S.; Chaudhary, S.; Kumar, A.; Ganapathy, A.; Kumar, A.; Mishra, V.

    2015-12-01

    Energy demand management, also known as demand side management (DSM), is the modification of consumer demand for energy through various methods such as smart metering, incentive based schemes, payments for turning off loads or rescheduling loads. Usually, the goal of demand side management is to encourage the consumer to use less power during periods of peak demand, or to move the time of energy use to off-peak times. Peak demand management does not necessarily decrease total energy consumption, but could be expected to reduce the need for investments in networks and/or power plants for meeting peak demands. Electricity use can vary dramatically on short and medium time frames, and the pricing system may not reflect the instantaneous cost as additional higher-cost that are brought on-line. In addition, the capacity or willingness of electricity consumers to adjust to prices by altering elasticity of demand may be low, particularly over short time frames. In the scenario of Indian grid setup, the retail customers do not follow real-time pricing and it is difficult to incentivize the utility companies for continuing the peak demand supply. A question for the future is how deeper penetration of renewable will be handled? This is a challenging problem since one has to deal with high variability, while managing loss of load probabilities. In the case of managing the peak demand using agriculture, in the future as smart metering matures with automatic turn on/off for a pump, it will become possible to provide an ensured amount of water or energy to the farmer while keeping the grid energized for 24 hours. Supply scenarios will include the possibility of much larger penetration of solar and wind into the grid. While, in absolute terms these sources are small contributors, their role will inevitably grow but DSM using agriculture could help reduce the capital cost. The other option is of advancing or delaying pump operating cycle even by several hours, will still ensure

  3. Advanced Control Technologies and Strategies Linking DemandResponse and Energy Efficiency

    SciTech Connect

    Kiliccote, Sila; Piette, Mary Ann

    2005-09-02

    This paper presents a preliminary framework to describe how advanced controls can support multiple modes of operations including both energy efficiency and demand response (DR). A general description of DR, its benefits, and nationwide status is outlined. The role of energy management and control systems for DR is described. Building systems such as HVAC and lighting that utilize control technologies and strategies for energy efficiency are mapped on to DR and demand shedding strategies are developed. Past research projects are presented to provide a context for the current projects. The economic case for implementing DR from a building owner perspective is also explored.

  4. Modeling Framework and Validation of a Smart Grid and Demand Response System for Wind Power Integration

    SciTech Connect

    Broeer, Torsten; Fuller, Jason C.; Tuffner, Francis K.; Chassin, David P.; Djilali, Ned

    2014-01-31

    Electricity generation from wind power and other renewable energy sources is increasing, and their variability introduces new challenges to the power system. The emergence of smart grid technologies in recent years has seen a paradigm shift in redefining the electrical system of the future, in which controlled response of the demand side is used to balance fluctuations and intermittencies from the generation side. This paper presents a modeling framework for an integrated electricity system where loads become an additional resource. The agent-based model represents a smart grid power system integrating generators, transmission, distribution, loads and market. The model incorporates generator and load controllers, allowing suppliers and demanders to bid into a Real-Time Pricing (RTP) electricity market. The modeling framework is applied to represent a physical demonstration project conducted on the Olympic Peninsula, Washington, USA, and validation simulations are performed using actual dynamic data. Wind power is then introduced into the power generation mix illustrating the potential of demand response to mitigate the impact of wind power variability, primarily through thermostatically controlled loads. The results also indicate that effective implementation of Demand Response (DR) to assist integration of variable renewable energy resources requires a diversity of loads to ensure functionality of the overall system.

  5. Insulin demand regulates β cell number via the unfolded protein response.

    PubMed

    Sharma, Rohit B; O'Donnell, Amy C; Stamateris, Rachel E; Ha, Binh; McCloskey, Karen M; Reynolds, Paul R; Arvan, Peter; Alonso, Laura C

    2015-10-01

    Although stem cell populations mediate regeneration of rapid turnover tissues, such as skin, blood, and gut, a stem cell reservoir has not been identified for some slower turnover tissues, such as the pancreatic islet. Despite lacking identifiable stem cells, murine pancreatic β cell number expands in response to an increase in insulin demand. Lineage tracing shows that new β cells are generated from proliferation of mature, differentiated β cells; however, the mechanism by which these mature cells sense systemic insulin demand and initiate a proliferative response remains unknown. Here, we identified the β cell unfolded protein response (UPR), which senses insulin production, as a regulator of β cell proliferation. Using genetic and physiologic models, we determined that among the population of β cells, those with an active UPR are more likely to proliferate. Moreover, subthreshold endoplasmic reticulum stress (ER stress) drove insulin demand-induced β cell proliferation, through activation of ATF6. We also confirmed that the UPR regulates proliferation of human β cells, suggesting that therapeutic UPR modulation has potential to expand β cell mass in people at risk for diabetes. Together, this work defines a stem cell-independent model of tissue homeostasis, in which differentiated secretory cells use the UPR sensor to adapt organ size to meet demand.

  6. Insulin demand regulates β cell number via the unfolded protein response.

    PubMed

    Sharma, Rohit B; O'Donnell, Amy C; Stamateris, Rachel E; Ha, Binh; McCloskey, Karen M; Reynolds, Paul R; Arvan, Peter; Alonso, Laura C

    2015-10-01

    Although stem cell populations mediate regeneration of rapid turnover tissues, such as skin, blood, and gut, a stem cell reservoir has not been identified for some slower turnover tissues, such as the pancreatic islet. Despite lacking identifiable stem cells, murine pancreatic β cell number expands in response to an increase in insulin demand. Lineage tracing shows that new β cells are generated from proliferation of mature, differentiated β cells; however, the mechanism by which these mature cells sense systemic insulin demand and initiate a proliferative response remains unknown. Here, we identified the β cell unfolded protein response (UPR), which senses insulin production, as a regulator of β cell proliferation. Using genetic and physiologic models, we determined that among the population of β cells, those with an active UPR are more likely to proliferate. Moreover, subthreshold endoplasmic reticulum stress (ER stress) drove insulin demand-induced β cell proliferation, through activation of ATF6. We also confirmed that the UPR regulates proliferation of human β cells, suggesting that therapeutic UPR modulation has potential to expand β cell mass in people at risk for diabetes. Together, this work defines a stem cell-independent model of tissue homeostasis, in which differentiated secretory cells use the UPR sensor to adapt organ size to meet demand. PMID:26389675

  7. 41 CFR 105-60.606 - Procedure where response to demand is required prior to receiving instructions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Employees in Response to Subpoenas or Similar Demands in Judicial or Administrative Proceedings § 105-60.606 Procedure where response to demand is required prior to receiving instructions. (a) If a response to a... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Procedure where...

  8. 29 CFR 37.25 - What are the responsibilities of an Equal Opportunity Officer?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true What are the responsibilities of an Equal Opportunity Officer? 37.25 Section 37.25 Labor Office of the Secretary of Labor IMPLEMENTATION OF THE NONDISCRIMINATION AND EQUAL OPPORTUNITY PROVISIONS OF THE WORKFORCE INVESTMENT ACT OF 1998 (WIA) Recordkeeping...

  9. “Omics” of Maize Stress Response for Sustainable Food Production: Opportunities and Challenges

    PubMed Central

    Gong, Fangping; Yang, Le; Tai, Fuju; Hu, Xiuli

    2014-01-01

    Abstract Maize originated in the highlands of Mexico approximately 8700 years ago and is one of the most commonly grown cereal crops worldwide, followed by wheat and rice. Abiotic stresses (primarily drought, salinity, and high and low temperatures), together with biotic stresses (primarily fungi, viruses, and pests), negatively affect maize growth, development, and eventually production. To understand the response of maize to abiotic and biotic stresses and its mechanism of stress tolerance, high-throughput omics approaches have been used in maize stress studies. Integrated omics approaches are crucial for dissecting the temporal and spatial system-level changes that occur in maize under various stresses. In this comprehensive analysis, we review the primary types of stresses that threaten sustainable maize production; underscore the recent advances in maize stress omics, especially proteomics; and discuss the opportunities, challenges, and future directions of maize stress omics, with a view to sustainable food production. The knowledge gained from studying maize stress omics is instrumental for improving maize to cope with various stresses and to meet the food demands of the exponentially growing global population. Omics systems science offers actionable potential solutions for sustainable food production, and we present maize as a notable case study. PMID:25401749

  10. "Omics" of maize stress response for sustainable food production: opportunities and challenges.

    PubMed

    Gong, Fangping; Yang, Le; Tai, Fuju; Hu, Xiuli; Wang, Wei

    2014-12-01

    Maize originated in the highlands of Mexico approximately 8700 years ago and is one of the most commonly grown cereal crops worldwide, followed by wheat and rice. Abiotic stresses (primarily drought, salinity, and high and low temperatures), together with biotic stresses (primarily fungi, viruses, and pests), negatively affect maize growth, development, and eventually production. To understand the response of maize to abiotic and biotic stresses and its mechanism of stress tolerance, high-throughput omics approaches have been used in maize stress studies. Integrated omics approaches are crucial for dissecting the temporal and spatial system-level changes that occur in maize under various stresses. In this comprehensive analysis, we review the primary types of stresses that threaten sustainable maize production; underscore the recent advances in maize stress omics, especially proteomics; and discuss the opportunities, challenges, and future directions of maize stress omics, with a view to sustainable food production. The knowledge gained from studying maize stress omics is instrumental for improving maize to cope with various stresses and to meet the food demands of the exponentially growing global population. Omics systems science offers actionable potential solutions for sustainable food production, and we present maize as a notable case study.

  11. Effects of working memory demand on neural mechanisms of motor response selection and control.

    PubMed

    Barber, Anita D; Caffo, Brian S; Pekar, James J; Mostofsky, Stewart H

    2013-08-01

    Inhibitory control commonly recruits a number of frontal regions: pre-supplementary motor area (pre-SMA), frontal eye fields (FEFs), and right-lateralized posterior inferior frontal gyrus (IFG), dorsal anterior insula (DAI), dorsolateral prefrontal cortex (DLPFC), and inferior frontal junction (IFJ). These regions may directly implement inhibitory motor control or may be more generally involved in executive control functions. Two go/no-go tasks were used to distinguish regions specifically recruited for inhibition from those that additionally show increased activity with working memory demand. The pre-SMA and IFG were recruited for inhibition in both tasks and did not have greater activation for working memory demand on no-go trials, consistent with a role in inhibitory control. Activation in pre-SMA also responded to response selection demand and was increased with working memory on go trials specifically. The bilateral FEF and right DAI were commonly active for no-go trials. The FEF was also recruited to a greater degree with working memory demand on go trials and may bias top-down information when stimulus-response mappings change. The DAI, additionally responded to increased working memory demand on both go and no-go trials and may be involved in accessing sustained task information, alerting, or autonomic changes when cognitive demands increase. DLPFC activation was consistent with a role in working memory retrieval on both go and no-go trials. The inferior frontal junction, on the other hand, had greater activation with working memory specifically for no-go trials and may detect salient stimuli when the task requires frequent updating of working memory representations.

  12. A carbohydrate supply and demand model of vegetative growth: response to temperature and light.

    PubMed

    Gent, Martin P N; Seginer, Ido

    2012-07-01

    Photosynthesis is the limiting factor in crop growth models, but metabolism may also limit growth. We hypothesize that, over a wide range of temperature, growth is the minimum of the supply of carbohydrate from photosynthesis, and the demand of carbohydrate to synthesize new tissue. Biosynthetic demand limits growth at cool temperatures and increases exponentially with temperature. Photosynthesis limits growth at warm temperatures and decreases with temperature. Observations of tomato seedlings were used to calibrate a model based on this hypothesis. Model predictions were tested with published data for growth and carbohydrate content of sunflower and wheat. The model qualitatively fitted the response of growth of tomato and sunflower to both cool and warm temperatures. The transition between demand and supply limitation occurred at warmer temperatures under higher light and faster photosynthesis. Modifications were required to predict the observed non-structural carbohydrate (NSC). Some NSC was observed at warm temperatures, where demand should exceed supply. It was defined as a required reserve. Less NSC was found at cool temperatures than predicted from the difference between supply and demand. This was explained for tomato and sunflower, by feedback inhibition of NSC on photosynthesis. This inhibition was much less in winter wheat. PMID:22321060

  13. Open Automated Demand Response Technologies for Dynamic Pricing and Smart Grid

    SciTech Connect

    Ghatikar, Girish; Mathieu, Johanna L.; Piette, Mary Ann; Kiliccote, Sila

    2010-06-02

    We present an Open Automated Demand Response Communications Specifications (OpenADR) data model capable of communicating real-time prices to electricity customers. We also show how the same data model could be used to for other types of dynamic pricing tariffs (including peak pricing tariffs, which are common throughout the United States). Customers participating in automated demand response programs with building control systems can respond to dynamic prices by using the actual prices as inputs to their control systems. Alternatively, prices can be mapped into"building operation modes," which can act as inputs to control systems. We present several different strategies customers could use to map prices to operation modes. Our results show that OpenADR can be used to communicate dynamic pricing within the Smart Grid and that OpenADR allows for interoperability with existing and future systems, technologies, and electricity markets.

  14. Design and Operation of an Open, Interoperable Automated Demand Response Infrastructure for Commercial Buildings

    SciTech Connect

    Piette, Mary Ann; Ghatikar, Girish; Kiliccote, Sila; Watson, David; Koch, Ed; Hennage, Dan

    2009-05-01

    This paper describes the concept for and lessons from the development and field-testing of an open, interoperable communications infrastructure to support automated demand response (auto-DR). Automating DR allows greater levels of participation, improved reliability, and repeatability of the DR in participating facilities. This paper also presents the technical and architectural issues associated with auto-DR and description of the demand response automation server (DRAS), the client/server architecture-based middle-ware used to automate the interactions between the utilities or any DR serving entity and their customers for DR programs. Use case diagrams are presented to show the role of the DRAS between utility/ISO and the clients at the facilities.

  15. Demand response to improved walking infrastructure: A study into the economics of walking and health behaviour change.

    PubMed

    Longo, Alberto; Hutchinson, W George; Hunter, Ruth F; Tully, Mark A; Kee, Frank

    2015-10-01

    Walking is the most common form of moderate-intensity physical activity among adults, is widely accessible and especially appealing to obese people. Most often policy makers are interested in valuing the effect on walking of changes in some characteristics of a neighbourhood, the demand response for walking, of infrastructure changes. A positive demand response to improvements in the walking environment could help meet the public health target of 150 min of at least moderate-intensity physical activity per week. We model walking in an individual's local neighbourhood as a 'weak complement' to the characteristics of the neighbourhood itself. Walking is affected by neighbourhood characteristics, substitutes, and individual's characteristics, including their opportunity cost of time. Using compensating variation, we assess the economic benefits of walking and how walking behaviour is affected by improvements to the neighbourhood. Using a sample of 1209 respondents surveyed over a 12 month period (Feb 2010-Jan 2011) in East Belfast, United Kingdom, we find that a policy that increased walkability and people's perception of access to shops and facilities would lead to an increase in walking of about 36 min/person/week, valued at £13.65/person/week. When focussing on inactive residents, a policy that improved the walkability of the area would lead to guidelines for physical activity being reached by only 12.8% of the population who are currently inactive. Additional interventions would therefore be needed to encourage inactive residents to achieve the recommended levels of physical activity, as it appears that interventions that improve the walkability of an area are particularly effective in increasing walking among already active citizens, and, among the inactive ones, the best response is found among healthier, younger and wealthier citizens.

  16. Analysis of Open Automated Demand Response Deployments in California and Guidelines to Transition to Industry Standards

    SciTech Connect

    Ghatikar, Girish; Riess, David; Piette, Mary Ann

    2014-01-02

    This report reviews the Open Automated Demand Response (OpenADR) deployments within the territories serviced by California?s investor-owned utilities (IOUs) and the transition from the OpenADR 1.0 specification to the formal standard?OpenADR 2.0. As demand response service providers and customers start adopting OpenADR 2.0, it is necessary to ensure that the existing Automated Demand Response (AutoDR) infrastructure investment continues to be useful and takes advantage of the formal standard and its many benefits. This study focused on OpenADR deployments and systems used by the California IOUs and included a summary of the OpenADR deployment from the U.S. Department of Energy-funded demonstration conducted by the Sacramento Municipal Utility District (SMUD). Lawrence Berkeley National Laboratory collected and analyzed data about OpenADR 1.0 deployments, categorized architectures, developed a data model mapping to understand the technical compatibility of each version, and compared the capabilities and features of the two specifications. The findings, for the first time, provided evidence of the total enabled load shed and average first cost for system enablement in the IOU and SMUD service territories. The OpenADR 2.0a profile specification semantically supports AutoDR system architectures and data propagation with a testing and certification program that promotes interoperability, scaled deployments by multiple vendors, and provides additional features that support future services.

  17. Automated Demand Response Approaches to Household Energy Management in a Smart Grid Environment

    NASA Astrophysics Data System (ADS)

    Adika, Christopher Otieno

    The advancement of renewable energy technologies and the deregulation of the electricity market have seen the emergence of Demand response (DR) programs. Demand response is a cost-effective load management strategy which enables the electricity suppliers to maintain the integrity of the power grid during high peak periods, when the customers' electrical load is high. DR programs are designed to influence electricity users to alter their normal consumption patterns by offering them financial incentives. A well designed incentive-based DR scheme that offer competitive electricity pricing structure can result in numerous benefits to all the players in the electricity market. Lower power consumption during peak periods will significantly enhance the robustness of constrained networks by reducing the level of power of generation and transmission infrastructure needed to provide electric service. Therefore, this will ease the pressure of building new power networks as we avoiding costly energy procurements thereby translating into huge financial savings for the power suppliers. Peak load reduction will also reduce the inconveniences suffered by end users as a result of brownouts or blackouts. Demand response will also drastically lower the price peaks associated with wholesale markets. This will in turn reduce the electricity costs and risks for all the players in the energy market. Additionally, DR is environmentally friendly since it enhances the flexibility of the power grid through accommodation of renewable energy resources. Despite its many benefits, DR has not been embraced by most electricity networks. This can be attributed to the fact that the existing programs do not provide enough incentives to the end users and, therefore, most electricity users are not willing to participate in them. To overcome these challenges, most utilities are coming up with innovative strategies that will be more attractive to their customers. Thus, this dissertation presents various

  18. Empirical Analysis of the Spot Market Implications ofPrice-Responsive Demand

    SciTech Connect

    Siddiqui, Afzal S.; Bartholomew, Emily S.; Marnay, Chris

    2005-08-01

    Regardless of the form of restructuring, deregulatedelectricity industries share one common feature: the absence of anysignificant, rapid demand-side response to the wholesale (or, spotmarket) price. For a variety of reasons, most electricity consumers stillpay an average cost based regulated retail tariff held over from the eraof vertical integration, even as the retailers themselves are oftenforced to purchase electricity at volatile wholesale prices set in openmarkets. This results in considerable price risk for retailers, who aresometimes additionally forbidden by regulators from signing hedgingcontracts. More importantly, because end-users do not perceive real-time(or even hourly or daily) fluctuations in the wholesale price ofelectricity, they have no incentive to adjust their consumptionaccordingly. Consequently, demand for electricity is highly inelastic,which together with the non storability of electricity that requiresmarket clearing over very short time steps spawn many other problemsassociated with electricity markets, such as exercise of market power andprice volatility. Indeed, electricity generation resources can bestretched to the point where system adequacy is threatened. Economictheory suggests that even modest price responsiveness can relieve thestress on generation resources and decrease spot prices. To quantify thiseffect, actual generator bid data from the New York control area is usedto construct supply stacks and intersect them with demand curves ofvarious slopes to approximate the effect of different levels of demandresponse. The potential impact of real-time pricing (RTP) on theequilibrium spot price and quantity is then estimated. These resultsindicate the immediate benefits that could be derived from a moreprice-responsive demand providing policymakers with a measure of howprices can be potentially reduced and consumption maintained within thecapability of generation assets.

  19. Configuring load as a resource for competitive electricity markets--Review of demand response programs in the U.S. and around the world

    SciTech Connect

    Heffner, Grayson C.

    2002-09-01

    The restructuring of regional and national electricity markets in the U.S. and around the world has been accompanied by numerous problems, including generation capacity shortages, transmission congestion, wholesale price volatility, and reduced system reliability. These problems have created new opportunities for technologies and business approaches that allow load serving entities and other aggregators to control and manage the load patterns of wholesale and retail end-users they serve. Demand Response Programs, once called Load Management, have re-emerged as an important element in the fine-tuning of newly restructured electricity markets. During the summers of 1999 and 2001 they played a vital role in stabilizing wholesale markets and providing a hedge against generation shortfalls throughout the U.S.A. Demand Response Programs include ''traditional'' capacity reservation and interruptible/curtailable rates programs as well as voluntary demand bidding programs offered by either Load Serving Entities (LSEs) or regional Independent System Operators (ISOs). The Lawrence Berkeley National Lab (LBNL) has been monitoring the development of new types of Demand Response Programs both in the U.S. and around the world. This paper provides a survey and overview of the technologies and program designs that make up these emerging and important new programs.

  20. Visible light and near-infrared-responsive chromophores for drug delivery-on-demand applications.

    PubMed

    Linsley, Chase S; Quach, Viola Y; Agrawal, Gaurav; Hartnett, Elyse; Wu, Benjamin M

    2015-12-01

    The need for temporal-spatial control over the release of biologically active molecules has motivated efforts to engineer novel drug delivery-on-demand strategies actuated via light irradiation. Many systems, however, have been limited to in vitro proof-of-concept due to biocompatibility issues with the photo-responsive moieties or the light wavelength, intensity, and duration. To overcome these limitations, this paper describes a light actuated drug delivery-on-demand strategy that uses visible and near-infrared (NIR) light and biocompatible chromophores: cardiogreen, methylene blue, and riboflavin. All three chromophores are capable of significant photothermal reaction upon exposure to NIR and visible light, and the amount of temperature change is dependent upon light intensity, wavelength as well as chromophore concentration. Pulsatile release of bovine serum albumin (BSA) from thermally responsive hydrogels was achieved over 4 days. These findings have the potential to translate light-actuated drug delivery-on-demand systems from the bench to clinical applications that require explicit control over the presentation of biologically active molecules.

  1. Visible light and near infrared-responsive chromophores for drug delivery-on-demand applications

    PubMed Central

    Linsley, Chase S.; Quach, Viola Y.; Agrawal, Gaurav; Hartnett, Elyse; Wu, Benjamin M.

    2016-01-01

    The need for temporal-spatial control over the release of biologically active molecules has motivated efforts to engineer novel drug delivery-on-demand strategies actuated via light irradiation. Many systems, however, have been limited to in vitro proof-of-concept due to biocompatibility issues with the photo-responsive moieties or the light wavelength, intensity and duration. To overcome these limitations, this paper describes a light actuated drug delivery-on-demand strategy that uses visible and near infrared (NIR) light and biocompatible chromophores: cardiogreen, methylene blue and riboflavin. All 3 chromophores are capable of significant photothermal reaction upon exposure to NIR and visible light, and the amount of temperature change is dependent upon light intensity, wavelength as well as chromophore concentration. Pulsatile release of bovine serum albumin (BSA) from thermally-responsive hydrogels was achieved over 4 days. These findings have the potential to translate light actuated drug delivery-on-demand systems from the bench to clinical applications that require explicit control over the presentation of biologically active molecules. PMID:26423655

  2. Final Scientific Technical Report: INTEGRATED PREDICTIVE DEMAND RESPONSE CONTROLLER FOR COMMERCIAL BUILDINGS

    SciTech Connect

    Wenzel, Mike

    2013-10-14

    This project provides algorithms to perform demand response using the thermal mass of a building. Using the thermal mass of the building is an attractive method for performing demand response because there is no need for capital expenditure. The algorithms rely on the thermal capacitance inherent in the building?s construction materials. A near-optimal ?day ahead? predictive approach is developed that is meant to keep the building?s electrical demand constant during the high cost periods. This type of approach is appropriate for both time-of-use and critical peak pricing utility rate structures. The approach uses the past days data in order to determine the best temperature setpoints for the building during the high price periods on the next day. A second ?model predictive approach? (MPC) uses a thermal model of the building to determine the best temperature for the next sample period. The approach uses constant feedback from the building and is capable of appropriately handling real time pricing. Both approaches are capable of using weather forecasts to improve performance.

  3. Physiological demands of women's rugby union: time-motion analysis and heart rate response.

    PubMed

    Virr, Jody Lynn; Game, Alex; Bell, Gordon John; Syrotuik, Daniel

    2014-01-01

    The aim of this study was to determine the physical demands of women's rugby union match play using time-motion analysis and heart rate (HR) response. Thirty-eight premier club level female rugby players, ages 18-34 years were videotaped and HRs monitored for a full match. Performances were coded into 12 different movement categories: 5 speeds of locomotion (standing, walking, jogging, striding, sprinting), 4 forms of intensive non-running exertion (ruck/maul/tackle, pack down, scrum, lift) and 3 discrete activities (kick, jump, open field tackle). The main results revealed that backs spend significantly more time sprinting and walking whereas forwards spend more time in intensive non-running exertion and jogging. Forwards also had a significantly higher total work frequency compared to the backs, but a higher total rest frequency compared to the backs. In terms of HR responses, forwards displayed higher mean HRs throughout the match and more time above 80% of their maximum HR than backs. In summary, women's rugby union is characterised by intermittent bursts of high-intensity activity, where forwards and backs have similar anaerobic energy demands, but different specific match demands.

  4. Physiological demands of women's rugby union: time-motion analysis and heart rate response.

    PubMed

    Virr, Jody Lynn; Game, Alex; Bell, Gordon John; Syrotuik, Daniel

    2014-01-01

    The aim of this study was to determine the physical demands of women's rugby union match play using time-motion analysis and heart rate (HR) response. Thirty-eight premier club level female rugby players, ages 18-34 years were videotaped and HRs monitored for a full match. Performances were coded into 12 different movement categories: 5 speeds of locomotion (standing, walking, jogging, striding, sprinting), 4 forms of intensive non-running exertion (ruck/maul/tackle, pack down, scrum, lift) and 3 discrete activities (kick, jump, open field tackle). The main results revealed that backs spend significantly more time sprinting and walking whereas forwards spend more time in intensive non-running exertion and jogging. Forwards also had a significantly higher total work frequency compared to the backs, but a higher total rest frequency compared to the backs. In terms of HR responses, forwards displayed higher mean HRs throughout the match and more time above 80% of their maximum HR than backs. In summary, women's rugby union is characterised by intermittent bursts of high-intensity activity, where forwards and backs have similar anaerobic energy demands, but different specific match demands. PMID:24168428

  5. Hazard consistent structural demands and in-structure design response spectra

    SciTech Connect

    Houston, Thomas W; Costantino, Michael C; Costantino, Carl J

    2009-01-01

    Current analysis methodology for the Soil Structure Interaction (SSI) analysis of nuclear facilities is specified in ASCE Standard 4. This methodology is based on the use of deterministic procedures with the intention that enough conservatism is included in the specified procedures to achieve an 80% probability of non-exceedance in the computed response of a Structure, System. or Component for given a mean seismic design input. Recently developed standards are aimed at achieving performance-based, risk consistent seismic designs that meet specified target performance goals. These design approaches rely upon accurately characterizing the probability (hazard) level of system demands due to seismic loads consistent with Probabilistic Seismic Hazard Analyses. This paper examines the adequacy of the deterministic SSI procedures described in ASCE 4-98 to achieve an 80th percentile of Non-Exceedance Probability (NEP) in structural demand, given a mean seismic input motion. The study demonstrates that the deterministic procedures provide computed in-structure response spectra that are near or greater than the target 80th percentile NEP for site profiles other than those resulting in high levels of radiation damping. The deterministic procedures do not appear to be as robust in predicting peak accelerations, which correlate to structural demands within the structure.

  6. California DREAMing: The design of residential demand responsive technology with people in mind

    NASA Astrophysics Data System (ADS)

    Peffer, Therese Evelyn

    Electrical utilities worldwide are exploring "demand response" programs to reduce electricity consumption during peak periods. Californian electrical utilities would like to pass the higher cost of peak demand to customers to offset costs, increase reliability, and reduce peak consumption. Variable pricing strategies require technology to communicate a dynamic price to customers and respond to that price. However, evidence from thermostat and energy display studies as well as research regarding energy-saving behaviors suggests that devices cannot effect residential demand response without the sanction and participation of people. This study developed several technologies to promote or enable residential demand response. First, along with a team of students and professors, I designed and tested the Demand Response Electrical Appliance Manager (DREAM). This wireless network of sensors, actuators, and controller with a user interface provides information to intelligently control a residential heating and cooling system and to inform people of their energy usage. We tested the system with computer simulation and in the laboratory and field. Secondly, as part of my contribution to the team, I evaluated machine-learning to predict a person's seasonal temperature preferences by analyzing existing data from office workers. The third part of the research involved developing an algorithm that generated temperature setpoints based on outdoor temperature. My study compared the simulated energy use using these setpoints to that using the setpoints of a programmable thermostat. Finally, I developed and tested a user interface for a thermostat and in-home energy display. This research tested the effects of both energy versus price information and the context of sponsorship on the behavior of subjects. I also surveyed subjects on the usefulness of various displays. The wireless network succeeded in providing detailed data to enable an intelligent controller and provide feedback to

  7. Understanding the Effect of Baseline Modeling Implementation Choices on Analysis of Demand Response Performance

    SciTech Connect

    University of California, Berkeley; Addy, Nathan; Kiliccote, Sila; Mathieu, Johanna; Callaway, Duncan S.

    2012-06-13

    Accurate evaluation of the performance of buildings participating in Demand Response (DR) programs is critical to the adoption and improvement of these programs. Typically, we calculate load sheds during DR events by comparing observed electric demand against counterfactual predictions made using statistical baseline models. Many baseline models exist and these models can produce different shed calculations. Moreover, modelers implementing the same baseline model can make different modeling implementation choices, which may affect shed estimates. In this work, using real data, we analyze the effect of different modeling implementation choices on shed predictions. We focused on five issues: weather data source, resolution of data, methods for determining when buildings are occupied, methods for aligning building data with temperature data, and methods for power outage filtering. Results indicate sensitivity to the weather data source and data filtration methods as well as an immediate potential for automation of methods to choose building occupied modes.

  8. Reducing Gridlock on the Grid: Utility Trends in Managing Peak Electric Load through Residential Demand Response

    NASA Astrophysics Data System (ADS)

    McDonald, Betsy

    Utilities across the United States are piloting residential demand response programs to help manage peak electric demand. Using publicly available program evaluations, this thesis analyzes nine such programs to uncover and synthesize the range of program offerings, goals, enrollment strategies, and customer experiences. This review reveals that program participation, components, and results differ based on a variety of factors, including geographic characteristics, program goals, and implementation strategies. The diversity of program designs and evaluation findings suggests an underlying tension between the need to generate cost-effective program impacts and the desire to increase accessibility so that program benefits are not exclusive to certain segments of the population. For more significant and impactful engagement, program goals may need to shift. State level policy support could help shift program goals toward increasing program accessibility. Future research should explore creative strategies that target existing barriers and allow for more inclusive deployment.

  9. Automated Demand Response Technology Demonstration Project for Small and Medium Commercial Buildings

    SciTech Connect

    Page, Janie; Kiliccote, Sila; Dudley, Junqiao Han; Piette, Mary Ann; Chiu, Albert K.; Kellow, Bashar; Koch, Ed; Lipkin, Paul

    2011-07-01

    Small and medium commercial customers in California make up about 20-25% of electric peak load in California. With the roll out of smart meters to this customer group, which enable granular measurement of electricity consumption, the investor-owned utilities will offer dynamic prices as default tariffs by the end of 2011. Pacific Gas and Electric Company, which successfully deployed Automated Demand Response (AutoDR) Programs to its large commercial and industrial customers, started investigating the same infrastructures application to the small and medium commercial customers. This project aims to identify available technologies suitable for automating demand response for small-medium commercial buildings; to validate the extent to which that technology does what it claims to be able to do; and determine the extent to which customers find the technology useful for DR purpose. Ten sites, enabled by eight vendors, participated in at least four test AutoDR events per site in the summer of 2010. The results showed that while existing technology can reliably receive OpenADR signals and translate them into pre-programmed response strategies, it is likely that better levels of load sheds could be obtained than what is reported here if better understanding of the building systems were developed and the DR response strategies had been carefully designed and optimized for each site.

  10. Non-steady response of BOD biosensor for the determination of biochemical oxygen demand in wastewater.

    PubMed

    Velling, Siiri; Mashirin, Alexey; Hellat, Karin; Tenno, Toomas

    2011-01-01

    A biochemical oxygen demand (BOD) biosensor for effective and expeditious BOD(7) estimations was constructed and the non-steady phase of the output signal was extensively studied. The modelling approach introduced allows response curve reconstruction and a curve fitting procedure of good quality, resulting in parameters indicating the relationship between response and organic substrate concentration and stability properties of the BOD biosensor. Also, the immobilization matrixes of different thicknesses were characterized to determine their suitability for bio-sensing measurements in non-stationary conditions, as well as for the determination of the mechanical durability of the BOD biosensor in time. The non-steady response of the experimental output of the BOD biosensor was fitted according to the developed model that enables to determine the stability of the biosensor output and dependency on biodegradable organic substrate concentration. The calibration range of the studied BOD biosensor in OECD synthetic wastewater was 15-110 mg O(2) L(-1). Repeatability tests showed relative standard deviation (RSD) values of 2.8% and 5.8% for the parameter τ(d), characterizing the transient output of the amperometric oxygen sensor in time, and τ(s), describing the dependency of the transient response of the BOD biosensor on organic substrate concentration, respectively. BOD biosensor experiments for the evaluation of the biochemical oxygen demand of easily degradable and refractory municipal wastewater showed good concurrence with traditional BOD(7) analysis.

  11. Behavioral reactivity and addiction: the adaptation of behavioral response to reward opportunities.

    PubMed

    Trafton, Jodie A; Gifford, Elizabeth V

    2008-01-01

    Persons recovering from addiction must refrain from drug use even when the opportunity to use exists. Understanding how behavioral response to drug reward opportunities is modified is key to treating addiction. Most effective behavioral therapies encourage patients to increase reinforcement opportunities by engaging unidentified sources of nondrug reward. The authors integrate transdisciplinary research on the brain and behavioral effects of increasing reward availability to demonstrate one neurobiological mechanism by which behavioral therapies help patients abstain. Explicating neurobiological processes underlying psychotherapy provides predictions about the interaction between dopaminergic medications and therapy and the impact of individual differences in dopamine receptor expression on addiction vulnerability. PMID:18305282

  12. 10 CFR 202.25 - Procedure where a decision concerning a demand is not made prior to the time a response to the...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Procedure where a decision concerning a demand is not made prior to the time a response to the demand is required. 202.25 Section 202.25 Energy DEPARTMENT OF... is not made prior to the time a response to the demand is required. If response to the demand...

  13. Field Demonstration of Automated Demand Response for Both Winter and Summer Events in Large Buildings in the Pacific Northwest

    SciTech Connect

    Piette, Mary Ann; Kiliccote, Sila; Dudley, Junqiao H.

    2011-11-11

    There are growing strains on the electric grid as cooling peaks grow and equipment ages. Increased penetration of renewables on the grid is also straining electricity supply systems and the need for flexible demand is growing. This paper summarizes results of a series of field test of automated demand response systems in large buildings in the Pacific Northwest. The objective of the research was two fold. One objective was to evaluate the use demand response automation technologies. A second objective was to evaluate control strategies that could change the electric load shape in both winter and summer conditions. Winter conditions focused on cold winter mornings, a time when the electric grid is often stressed. The summer test evaluated DR strategies in the afternoon. We found that we could automate both winter and summer control strategies with the open automated demand response communication standard. The buildings were able to provide significant demand response in both winter and summer events.

  14. Response demands and the recruitment of heuristic strategies in syllogistic reasoning.

    PubMed

    Reverberi, Carlo; Rusconi, Patrice; Paulesu, Eraldo; Cherubini, Paolo

    2009-03-01

    Two experiments investigated whether dealing with a homogeneous subset of syllogisms with time-constrained responses encouraged participants to develop and use heuristics for abstract (Experiment 1) and thematic (Experiment 2) syllogisms. An atmosphere-based heuristic accounted for most responses with both abstract and thematic syllogisms. With thematic syllogisms, a weaker effect of a belief heuristic was also observed, mainly where the correct response was inconsistent with the atmosphere of the premises. Analytic processes appear to have played little role in the time-constrained condition, whereas their involvement increased in a self-paced, unconstrained condition. From a dual-process perspective, the results further specify how task demands affect the recruitment of heuristic and analytic systems of reasoning. Because the syllogisms and experimental procedure were the same as those used in a previous neuroimaging study by Goel, Buchel, Frith, and Dolan (2000), the result also deepen our understanding of the cognitive processes investigated by that study.

  15. Effects of Granular Control on Customers’ Perspective and Behavior with Automated Demand Response Systems

    SciTech Connect

    Schetrit, Oren; Kim, Joyce; Yin, Rongxin; Kiliccote, Sila

    2014-08-01

    Automated demand response (Auto-DR) is expected to close the loop between buildings and the grid by providing machine-to-machine communications to curtail loads without the need for human intervention. Hence, it can offer more reliable and repeatable demand response results to the grid than the manual approach and make demand response participation a hassle-free experience for customers. However, many building operators misunderstand Auto-DR and are afraid of losing control over their building operation. To ease the transition from manual to Auto-DR, we designed and implemented granular control of Auto-DR systems so that building operators could modify or opt out of individual load-shed strategies whenever they wanted. This paper reports the research findings from this effort demonstrated through a field study in large commercial buildings located in New York City. We focused on (1) understanding how providing granular control affects building operators’ perspective on Auto-DR, and (2) evaluating the usefulness of granular control by examining their interaction with the Auto-DR user interface during test events. Through trend log analysis, interviews, and surveys, we found that: (1) the opt-out capability during Auto-DR events can remove the feeling of being forced into load curtailments and increase their willingness to adopt Auto-DR; (2) being able to modify individual load-shed strategies allows flexible Auto-DR participation that meets the building’s changing operational requirements; (3) a clear display of automation strategies helps building operators easily identify how Auto-DR is functioning and can build trust in Auto-DR systems.

  16. A Successful Case Study of Small Business Energy Efficiency and Demand Response with Communicating Thermostats

    SciTech Connect

    Herter, Karen; Wayland, Seth; Rasin, Josh

    2009-08-12

    This report documents a field study of 78 small commercial customers in the Sacramento Municipal Utility District service territory who volunteered for an integrated energy-efficiency/demand-response (EE-DR) program in the summer of 2008. The original objective for the pilot was to provide a better understanding of demand response issues in the small commercial sector. Early findings justified a focus on offering small businesses (1) help with the energy efficiency of their buildings in exchange for occasional load shed, and (2) a portfolio of options to meet the needs of a diverse customer sector. To meet these expressed needs, the research pilot provided on-site energy efficiency advice and offered participants several program options, including the choice of either a dynamic rate or monthly payment for air-conditioning setpoint control. Overall results show that pilot participants had energy savings of 20%, and the potential for an additional 14% to 20% load drop during a 100 F demand response event. In addition to the efficiency-related bill savings, participants on the dynamic rate saved an estimated 5% on their energy costs compared to the standard rate. About 80% of participants said that the program met or surpassed their expectations, and three-quarters said they would probably or definitely participate again without the $120 participation incentive. These results provide evidence that energy efficiency programs, dynamic rates and load control programs can be used concurrently and effectively in the small business sector, and that communicating thermostats are a reliable tool for providing air-conditioning load shed and enhancing the ability of customers on dynamic rates to respond to intermittent price events.

  17. Small Business Demand Response with Communicating Thermostats: SMUD's Summer Solutions Research Pilot

    SciTech Connect

    Herter, Karen; Wayland, Seth; Rasin, Josh

    2009-09-25

    This report documents a field study of 78 small commercial customers in the Sacramento Municipal Utility District service territory who volunteered for an integrated energy-efficiency/demand-response (EE-DR) program in the summer of 2008. The original objective for the pilot was to provide a better understanding of demand response issues in the small commercial sector. Early findings justified a focus on offering small businesses (1) help with the energy efficiency of their buildings in exchange for occasional load shed, and (2) a portfolio of options to meet the needs of a diverse customer sector. To meet these expressed needs, the research pilot provided on-site energy efficiency advice and offered participants several program options, including the choice of either a dynamic rate or monthly payment for air-conditioning setpoint control. An analysis of hourly load data indicates that the offices and retail stores in our sample provided significant demand response, while the restaurants did not. Thermostat data provides further evidence that restaurants attempted to precool and reduce AC service during event hours, but were unable to because their air-conditioning units were undersized. On a 100 F reference day, load impacts of all participants during events averaged 14%, while load impacts of office and retail buildings (excluding restaurants) reached 20%. Overall, pilot participants including restaurants had 2007-2008 summer energy savings of 20% and bill savings of 30%. About 80% of participants said that the program met or surpassed their expectations, and three-quarters said they would probably or definitely participate again without the $120 participation incentive. These results provide evidence that energy efficiency programs, dynamic rates and load control programs can be used concurrently and effectively in the small business sector, and that communicating thermostats are a reliable tool for providing air-conditioning load shed and enhancing the ability

  18. Optimal Technology Investment and Operation in Zero-Net-Energy Buildings with Demand Response

    SciTech Connect

    Stadler , Michael; Siddiqui, Afzal; Marnay, Chris; ,, Hirohisa Aki; Lai, Judy

    2009-05-26

    The US Department of Energy has launched the Zero-Net-Energy (ZNE) Commercial Building Initiative (CBI) in order to develop commercial buildings that produce as much energy as they use. Its objective is to make these buildings marketable by 2025 such that they minimize their energy use through cutting-edge energy-efficient technologies and meet their remaining energy needs through on-site renewable energy generation. We examine how such buildings may be implemented within the context of a cost- or carbon-minimizing microgrid that is able to adopt and operate various technologies, such as photovoltaic (PV) on-site generation, heat exchangers, solar thermal collectors, absorption chillers, and passive / demand-response technologies. We use a mixed-integer linear program (MILP) that has a multi-criteria objective function: the minimization of a weighted average of the building's annual energy costs and carbon / CO2 emissions. The MILP's constraints ensure energy balance and capacity limits. In addition, constraining the building's energy consumed to equal its energy exports enables us to explore how energy sales and demand-response measures may enable compliance with the CBI. Using a nursing home in northern California and New York with existing tariff rates and technology data, we find that a ZNE building requires ample PV capacity installed to ensure electricity sales during the day. This is complemented by investment in energy-efficient combined heat and power equipment, while occasional demand response shaves energy consumption. A large amount of storage is also adopted, which may be impractical. Nevertheless, it shows the nature of the solutions and costs necessary to achieve ZNE. For comparison, we analyze a nursing home facility in New York to examine the effects of a flatter tariff structure and different load profiles. It has trouble reaching ZNE status and its load reductions as well as efficiency measures need to be more effective than those in the CA case

  19. Demand Response Spinning Reserve Demonstration -- Phase 2 Findings from the Summer of 2008

    SciTech Connect

    Eto, Joseph H.; Nelson-Hoffman, Janine; Parker, Eric; Bernier, Clark; Young, Paul; Sheehan, Dave; Kueck, John; Kirby, Brendan

    2009-04-30

    The Demand Response Spinning Reserve project is a pioneering demonstration showing that existing utility load-management assets can provide an important electricity system reliability resource known as spinning reserve. Using aggregated demand-side resources to provide spinning reserve as demonstrated in this project will give grid operators at the California Independent System Operator (CA ISO) and Southern California Edison (SCE) a powerful new tool to improve reliability, prevent rolling blackouts, and lower grid operating costs.In the first phase of this demonstration project, we target marketed SCE?s air-conditioning (AC) load-cycling program, called the Summer Discount Plan (SDP), to customers on a single SCE distribution feederand developed an external website with real-time telemetry for the aggregated loads on this feeder and conducted a large number of short-duration curtailments of participating customers? air-conditioning units to simulate provision of spinning reserve. In this second phase of the demonstration project, we explored four major elements that would be critical for this demonstration to make the transition to a commercial activity:1. We conducted load curtailments within four geographically distinct feeders to determine the transferability of target marketing approaches and better understand the performance of SCE?s load management dispatch system as well as variations in the AC use of SCE?s participating customers;2. We deployed specialized, near-real-time AC monitoring devices to improve our understanding of the aggregated load curtailments we observe on the feeders;3. We integrated information provided by the AC monitoring devices with information from SCE?s load management dispatch system to measure the time required for each step in the curtailment process; and4. We established connectivity with the CA ISO to explore the steps involved in responding to CA ISO-initiated requests for dispatch of spinning reserve.The major findings from

  20. Impacts of demand response and renewable generation in electricity power market

    NASA Astrophysics Data System (ADS)

    Zhao, Zhechong

    This thesis presents the objective of the research which is to analyze the impacts of uncertain wind power and demand response on power systems operation and power market clearing. First, in order to effectively utilize available wind generation, it is usually given the highest priority by assigning zero or negative energy bidding prices when clearing the day-ahead electric power market. However, when congestion occurs, negative wind bidding prices would aggravate locational marginal prices (LMPs) to be negative in certain locations. A load shifting model is explored to alleviate possible congestions and enhance the utilization of wind generation, by shifting proper amount of load from peak hours to off peaks. The problem is to determine proper amount of load to be shifted, for enhancing the utilization of wind generation, alleviating transmission congestions, and making LMPs to be non-negative values. The second piece of work considered the price-based demand response (DR) program which is a mechanism for electricity consumers to dynamically manage their energy consumption in response to time-varying electricity prices. It encourages consumers to reduce their energy consumption when electricity prices are high, and thereby reduce the peak electricity demand and alleviate the pressure to power systems. However, it brings additional dynamics and new challenges on the real-time supply and demand balance. Specifically, price-sensitive DR load levels are constantly changing in response to dynamic real-time electricity prices, which will impact the economic dispatch (ED) schedule and in turn affect electricity market clearing prices. This thesis adopts two methods for examining the impacts of different DR price elasticity characteristics on the stability performance: a closed-loop iterative simulation method and a non-iterative method based on the contraction mapping theorem. This thesis also analyzes the financial stability of DR load consumers, by incorporating

  1. Market and policy barriers for demand response providing ancillary services in U.S. markets

    SciTech Connect

    Cappers, Peter; MacDonald, Jason; Goldman, Charles

    2013-03-01

    This study provides an examination of various market and policy barriers to demand response providing ancillary services in both ISO/RTO and non-ISO/RTO regions, especially at the program provider level. It is useful to classify barriers in order to create a holistic understanding and identify parties that could be responsible for their removal. This study develops a typology of barriers focusing on smaller customers that must rely on a program provider (i.e., electric investor owned utility or IOU, ARC) to create an aggregated DR resource in order to bring ancillary services to the balancing authority. The barriers were identified through examinations of regulatory structures, market environments, and product offerings; and discussions with industry stakeholders and regulators. In order to help illustrate the differences in barriers among various wholesale market designs and their constituent retail environments, four regions were chosen to use as case studies: Colorado, Texas, Wisconsin, and New Jersey.

  2. A Methodology for Estimating Large-Customer Demand Response MarketPotential

    SciTech Connect

    Goldman, Charles; Hopper, Nicole; Bharvirkar, Ranjit; Neenan,Bernie; Cappers,Peter

    2007-08-01

    Demand response (DR) is increasingly recognized as an essential ingredient to well-functioning electricity markets. DR market potential studies can answer questions about the amount of DR available in a given area and from which market segments. Several recent DR market potential studies have been conducted, most adapting techniques used to estimate energy-efficiency (EE) potential. In this scoping study, we: reviewed and categorized seven recent DR market potential studies; recommended a methodology for estimating DR market potential for large, non-residential utility customers that uses price elasticities to account for behavior and prices; compiled participation rates and elasticity values from six DR options offered to large customers in recent years, and demonstrated our recommended methodology with large customer market potential scenarios at an illustrative Northeastern utility. We observe that EE and DR have several important differences that argue for an elasticity approach for large-customer DR options that rely on customer-initiated response to prices, rather than the engineering approaches typical of EE potential studies. Base-case estimates suggest that offering DR options to large, non-residential customers results in 1-3% reductions in their class peak demand in response to prices or incentive payments of $500/MWh. Participation rates (i.e., enrollment in voluntary DR programs or acceptance of default hourly pricing) have the greatest influence on DR impacts of all factors studied, yet are the least well understood. Elasticity refinements to reflect the impact of enabling technologies and response at high prices provide more accurate market potential estimates, particularly when arc elasticities (rather than substitution elasticities) are estimated.

  3. ISO New England: Results of Ancillary Service Pilot Programs, Alternative Technology Regulation Pilot Program and Demand Response Reserves Pilot Program

    SciTech Connect

    Lowell, Jon; Yoshimura, Henry

    2011-10-26

    This PowerPoint presentation compares performance of pilot program assets and generation resources in alternative technology regulation and demand response reserves for flywheels and residential electric thermal storage.

  4. Response Cards as a Strategy for Increasing Opportunities to Respond: An Examination of the Evidence

    ERIC Educational Resources Information Center

    Schnorr, Crystalyn I.; Freeman-Green, Shaqwana; Test, David W.

    2016-01-01

    This study evaluated the quality of the research and evidence base for using response cards to increase opportunities to respond (OTR) for students with and without disabilities at the elementary level (i.e., kindergarten through Grade 5). Using quality indicator criteria for single-case research, six single-case studies investigating response…

  5. The Personal Responsibility and Work Opportunity Act of 1996: What Welfare Reform Means for Head Start.

    ERIC Educational Resources Information Center

    Shuell, Julie; Hanna, Jeff; Oterlei, Jannell; Kariger, Patricia

    This National Head Start Association booklet outlines the main provisions of the Personal Responsibility and Work Opportunity Act and describes how it may affect local Head Start Programs. The document is intended to serve as a starting point for local programs, parents, administrators and policy workers to discuss and plan how Head Start will…

  6. Web-based energy information systems for energy management and demand response in commercial buildings

    SciTech Connect

    Motegi, Naoya; Piette, Mary Ann; Kinney, Satkartar; Herter, Karen

    2003-04-18

    Energy Information Systems (EIS) for buildings are becoming widespread in the U.S., with more companies offering EIS products every year. As a result, customers are often overwhelmed by the quickly expanding portfolio of EIS feature and application options, which have not been clearly identified for consumers. The object of this report is to provide a technical overview of currently available EIS products. In particular, this report focuses on web-based EIS products for large commercial buildings, which allow data access and control capabilities over the Internet. EIS products combine software, data acquisition hardware, and communication systems to collect, analyze and display building information to aid commercial building energy managers, facility managers, financial managers and electric utilities in reducing energy use and costs in buildings. Data types commonly processed by EIS include energy consumption data; building characteristics; building system data, such as heating, ventilation, and air-conditioning (HVAC) and lighting data; weather data; energy price signals; and energy demand-response event information. This project involved an extensive review of research and trade literature to understand the motivation for EIS technology development. This study also gathered information on currently commercialized EIS. This review is not an exhaustive analysis of all EIS products; rather, it is a technical framework and review of current products on the market. This report summarizes key features available in today's EIS, along with a categorization framework to understand the relationship between EIS, Energy Management and Control Systems (EMCSs), and similar technologies. Four EIS types are described: Basic Energy Information Systems (Basic-EIS); Demand Response Systems (DRS); Enterprise Energy Management (EEM); and Web-based Energy Management and Control Systems (Web-EMCS). Within the context of these four categories, the following characteristics of EIS are

  7. Modeling of Electric Water Heaters for Demand Response: A Baseline PDE Model

    SciTech Connect

    Xu, Zhijie; Diao, Ruisheng; Lu, Shuai; Lian, Jianming; Zhang, Yu

    2014-09-05

    Demand response (DR)control can effectively relieve balancing and frequency regulation burdens on conventional generators, facilitate integrating more renewable energy, and reduce generation and transmission investments needed to meet peak demands. Electric water heaters (EWHs) have a great potential in implementing DR control strategies because: (a) the EWH power consumption has a high correlation with daily load patterns; (b) they constitute a significant percentage of domestic electrical load; (c) the heating element is a resistor, without reactive power consumption; and (d) they can be used as energy storage devices when needed. Accurately modeling the dynamic behavior of EWHs is essential for designing DR controls. Various water heater models, simplified to different extents, were published in the literature; however, few of them were validated against field measurements, which may result in inaccuracy when implementing DR controls. In this paper, a partial differential equation physics-based model, developed to capture detailed temperature profiles at different tank locations, is validated against field test data for more than 10 days. The developed model shows very good performance in capturing water thermal dynamics for benchmark testing purposes

  8. Optimal Control of Distributed Energy Resources and Demand Response under Uncertainty

    SciTech Connect

    Siddiqui, Afzal; Stadler, Michael; Marnay, Chris; Lai, Judy

    2010-06-01

    We take the perspective of a microgrid that has installed distribution energy resources (DER) in the form of distributed generation with combined heat and power applications. Given uncertain electricity and fuel prices, the microgrid minimizes its expected annual energy bill for various capacity sizes. In almost all cases, there is an economic and environmental advantage to using DER in conjunction with demand response (DR): the expected annualized energy bill is reduced by 9percent while CO2 emissions decline by 25percent. Furthermore, the microgrid's risk is diminished as DER may be deployed depending on prevailing market conditions and local demand. In order to test a policy measure that would place a weight on CO2 emissions, we use a multi-criteria objective function that minimizes a weighted average of expected costs and emissions. We find that greater emphasis on CO2 emissions has a beneficial environmental impact only if DR is available and enough reserve generation capacity exists. Finally, greater uncertainty results in higher expected costs and risk exposure, the effects of which may be mitigated by selecting a larger capacity.

  9. Female but not male zebra finches adjust heat output in response to increased incubation demand.

    PubMed

    Hill, Davina L; Lindström, Jan; McCafferty, Dominic J; Nager, Ruedi G

    2014-04-15

    In many incubating birds, heat transfer from parent to egg is facilitated by the brood patch, an area of ventral abdominal skin that becomes highly vascularised, swells and loses its down feathers around the time of laying. Only the female develops a brood patch in most passerine species, but males of some species can incubate and maintain the eggs at similar temperatures to females even without a brood patch. Here we used a novel application of infrared thermography to examine sex differences in parental care from a physiological perspective. Using incubating male and female zebra finches (Taeniopygia guttata), a species in which the male lacks a brood patch, we measured the surface temperature of the ventral plumage overlying the abdomen and a reference area that does not contact the eggs (thorax) twice per pair. In half of the pairs, clutch size was experimentally enlarged between the two sets of measurements to increase incubation demand. We found that the temperature differential between abdomen and thorax plumage was greater in females than in males, and that abdomen plumage was warmer after clutch enlargement than before in females but not in males. These findings are consistent with morphological sex differences in brood patch development and suggest that male and female zebra finches differ in the way they regulate abdomen versus general body surface temperature in response to variation in incubation demand.

  10. Light-responsive polymer nanoreactors: a source of reactive oxygen species on demand.

    PubMed

    Baumann, Patric; Balasubramanian, Vimalkumar; Onaca-Fischer, Ozana; Sienkiewicz, Andrzej; Palivan, Cornelia G

    2013-01-01

    Various domains present the challenges of responding to stimuli in a specific manner, with the desired sensitivity or functionality, and only when required. Stimuli-responsive systems that are appropriately designed can effectively meet these challenges. Here, we introduce nanoreactors that encapsulate photosensitizer-protein conjugates in polymer vesicles as a source of "on demand" reactive oxygen species. Vesicles made of poly(2-methyloxazoline)-poly(dimethylsiloxane)-poly(2-methyloxazoline) successfully encapsulated the photosensitizer Rose Bengal-bovine serum albumin conjugate (RB-BSA) during a self-assembly process, as demonstrated by UV-Vis spectroscopy. A combination of light scattering and transmission electron microscopy indicated that the nanoreactors are stable over time. They serve a dual role: protecting the photosensitizer in the inner cavity and producing in situ reactive oxygen species (ROS) upon irradiation with appropriate electromagnetic radiation. Illumination with appropriate wavelength light allows us to switch on/off and to control the production of ROS. Because of the oxygen-permeable nature of the polymer membrane of vesicles, ROS escape into the environment around vesicles, as established by electron paramagnetic resonance. The light-sensitive nanoreactor is taken up by HeLa cells in a Trojan horse fashion: it is nontoxic and, when irradiated with the appropriate laser light, produces ROS that induce cell death in a precise area corresponding to the irradiation zone. These nanoreactors can be used in theranostic approaches because they can be detected via the fluorescent photosensitizer signal and simultaneously produce ROS efficiently "on demand".

  11. Convergent and Divergent fMRI Responses in Children and Adults to Increasing Language Production Demands

    PubMed Central

    Krishnan, Saloni; Leech, Robert; Mercure, Evelyne; Lloyd-Fox, Sarah; Dick, Frederic

    2015-01-01

    In adults, patterns of neural activation associated with perhaps the most basic language skill—overt object naming—are extensively modulated by the psycholinguistic and visual complexity of the stimuli. Do children's brains react similarly when confronted with increasing processing demands, or they solve this problem in a different way? Here we scanned 37 children aged 7–13 and 19 young adults who performed a well-normed picture-naming task with 3 levels of difficulty. While neural organization for naming was largely similar in childhood and adulthood, adults had greater activation in all naming conditions over inferior temporal gyri and superior temporal gyri/supramarginal gyri. Manipulating naming complexity affected adults and children quite differently: neural activation, especially over the dorsolateral prefrontal cortex, showed complexity-dependent increases in adults, but complexity-dependent decreases in children. These represent fundamentally different responses to the linguistic and conceptual challenges of a simple naming task that makes no demands on literacy or metalinguistics. We discuss how these neural differences might result from different cognitive strategies used by adults and children during lexical retrieval/production as well as developmental changes in brain structure and functional connectivity. PMID:24907249

  12. Selective alignment of brain responses by task demands during semantic processing.

    PubMed

    Baggio, Giosuè

    2012-04-01

    The way the brain binds together words to form sentences may depend on whether and how the arising cognitive representation is to be used in behavior. The amplitude of the N400 effect in event-related brain potentials is inversely correlated with the degree of fit of a word's meaning into a semantic representation of the preceding discourse. This study reports a double dissociation in the latency characteristics of the N400 effect depending on task demands. When participants silently read words in a sentence context, without issuing a relevant overt response, greater temporal alignment over recording sites occurs for N400 onsets than peaks. If however a behavior is produced - here pressing a button in a binary probe selection task - exactly the opposite pattern is observed, with stronger alignment of N400 peaks than onsets. The peak amplitude of the N400 effect correlates best with the latency characteristic showing less temporal dispersion. These findings suggest that meaning construction in the brain is subtly affected by task demands, and that there is complex functional integration between semantic combinatorics and control systems handling behavioral goals. PMID:22245013

  13. Heat Pump Water Heaters: Controlled Field Research of Impact on Space Conditioning and Demand Response Characteristics

    SciTech Connect

    Parker, Graham B.; Widder, Sarah H.; Eklund, Ken; Petersen, Joseph M.; Sullivan, Greg

    2015-10-05

    A new generation of heat pump water heaters (HPWH) has been introduced into the U.S. market that promises to provide significant energy savings for water heating. Many electric utilities are promoting their widespread adoption as a key technology for meeting energy conservation goals and reducing greenhouse gas emissions. There is, however, considerable uncertainty regarding the space conditioning impact of an HPWH installed in a conditioned space. There is also uncertainty regarding the potential for deployment of HPWHs in demand response (DR) programs to help manage and balance peak utility loads in a similar manner as conventional electric resistance water heaters (ERWH). To help answer these uncertainties, controlled experiments have been undertaken over 30 months in a matched pair of unoccupied Lab Homes located on the campus of the Pacific Northwest National Laboratory (PNNL) in Richland, Washington.

  14. Dual Stimuli-Responsive Poly(β-amino ester) Nanoparticles for On-Demand Burst Release.

    PubMed

    Lee, Jung Seok; Deng, Xiaojian; Han, Patrick; Cheng, Jianjun

    2015-09-01

    We designed poly(β-amino esters) (PBAEs) bearing both UV light- and pH-sensitive groups and used PBAEs to prepare nanoparticles (NPs) that can be utilized for on-demand burst release of guest molecules in response to multiple triggers. Due to the presence of the photo-cleavable group in each repeating unit of PBAE, rapid release of encapsulated model drug could be achieved even with exposures to low intensity UV (10 mW · cm(-2) ). Especially, the burst release was further accelerated by additional UV treatments in the acidic condition showing the combinatory effect of dual stimuli. We believe these PBAE-based NPs can potentially be used to design intelligent controlled release device and nanomedicines.

  15. Estimating Large-Customer Demand Response Market Potential:Integrating Price and Customer Behavior

    SciTech Connect

    Goldman, Charles; Hopper, Nicole; Bharvirkar, Ranjit; Neenan,Bernie; Cappers, Peter

    2007-06-01

    ABSTRACT=Demand response (DR) is increasingly recognized asan essential ingredient to well-functioning electricity markets. DRmarket potential studies can answer questions about the amount of DRavailable in a given area, from which market segments. Several recent DRmarket potential studies have been conducted, most adapting techniquesused to estimate energy-efficiency (EE) potential. In this scoping study,we: reviewed and categorized seven recent DR market potential studies;recommended a methodology for estimating DR market potential for large,non-residential utility customers that uses price elasticities to accountfor behavior and prices; compiled participation rates and elasticityvalues from six DR options offered to large customers in recent years,and demonstrated our recommended methodology with large customer marketpotential scenarios at an illustrative Northeastern utility. We recommendan elasticity approach for large-customer DR options that rely oncusto!

  16. Compensatory vasodilatation during hypoxic exercise: mechanisms responsible for matching oxygen supply to demand.

    PubMed

    Casey, Darren P; Joyner, Michael J

    2012-12-15

    Hypoxia can have profound influences on the circulation. In humans, acute exposure to moderate hypoxia has been demonstrated to result in vasodilatation in the coronary, cerebral, splanchnic and skeletal muscle vascular beds. The combination of submaximal exercise and hypoxia produces a 'compensatory' vasodilatation and augmented blood flow in contracting skeletal muscles relative to the same level of exercise under normoxic conditions. This augmented vasodilatation exceeds that predicted by a simple sum of the individual dilator responses to hypoxia alone and normoxic exercise. Additionally, this enhanced hypoxic exercise hyperaemia is proportional to the hypoxia-induced fall in arterial oxygen (O(2)) content, thus preserving muscle O(2) delivery and ensuring it is matched to demand. Several vasodilator pathways have been proposed and examined as likely regulators of skeletal muscle blood flow in response to changes in arterial O(2) content. The purpose of this review is to put into context the present evidence regarding mechanisms responsible for the compensatory vasodilatation observed during hypoxic exercise in humans. Along these lines, this review will highlight the interactions between various local metabolic and endothelial derived substances that influence vascular tone during hypoxic exercise.

  17. 49 CFR 37.77 - Purchase or lease of new non-rail vehicles by public entities operating a demand responsive...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... public entities operating a demand responsive system for the general public. 37.77 Section 37.77...-rail vehicles by public entities operating a demand responsive system for the general public. (a) Except as provided in this section, a public entity operating a demand responsive system for the...

  18. Stomatal response of an anisohydric grapevine cultivar to evaporative demand, available soil moisture and abscisic acid.

    PubMed

    Rogiers, Suzy Y; Greer, Dennis H; Hatfield, Jo M; Hutton, Ron J; Clarke, Simon J; Hutchinson, Paul A; Somers, Anthony

    2012-03-01

    Stomatal responsiveness to evaporative demand (air vapour pressure deficit (VPD)) ranges widely between species and cultivars, and mechanisms for stomatal control in response to VPD remain obscure. The interaction of irrigation and soil moisture with VPD on stomatal conductance is particularly difficult to predict, but nevertheless is critical to instantaneous transpiration and vulnerability to desiccation. Stomatal sensitivity to VPD and soil moisture was investigated in Semillon, an anisohydric Vitis vinifera L. variety whose leaf water potential (Ψ(l)) is frequently lower than that of other grapevine varieties grown under similar conditions in the warm grape-growing regions of Australia. A survey of Semillon vines across seven vineyards revealed that, regardless of irrigation treatment, midday Ψ(l) was dependent on not only soil moisture but VPD at the time of measurement. Predawn Ψ(l) was more closely correlated to not only soil moisture in dry vineyards but to night-time VPD in drip-irrigated vineyards, with incomplete rehydration during high night-time VPD. Daytime stomatal conductance was low only under severe plant water deficits, induced by extremes in dry soil. Stomatal response to VPD was inconsistent across irrigation regime; however, in an unirrigated vineyard, stomatal sensitivity to VPD-the magnitude of stomatal response to VPD-was heightened under dry soils. It was also found that stomatal sensitivity was proportional to the magnitude of stomatal conductance at a reference VPD of 1kPa. Exogenous abscisic acid (ABA) applied to roots of Semillon vines growing in a hydroponic system induced stomatal closure and, in field vines, petiole xylem sap ABA concentrations rose throughout the morning and were higher in vines with low Ψ(l). These data indicate that despite high stomatal conductance of this anisohydric variety when grown in medium to high soil moisture, increased concentrations of ABA as a result of very limited soil moisture may augment

  19. 45 CFR 287.35 - What grant amounts are available under the Personal Responsibility and Work Opportunity...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What grant amounts are available under the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA) for the NEW Program? 287... the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA) for the...

  20. Light-responsive polymer nanoreactors: a source of reactive oxygen species on demand

    NASA Astrophysics Data System (ADS)

    Baumann, Patric; Balasubramanian, Vimalkumar; Onaca-Fischer, Ozana; Sienkiewicz, Andrzej; Palivan, Cornelia G.

    2012-12-01

    Various domains present the challenges of responding to stimuli in a specific manner, with the desired sensitivity or functionality, and only when required. Stimuli-responsive systems that are appropriately designed can effectively meet these challenges. Here, we introduce nanoreactors that encapsulate photosensitizer-protein conjugates in polymer vesicles as a source of ``on demand'' reactive oxygen species. Vesicles made of poly(2-methyloxazoline)-poly(dimethylsiloxane)-poly(2-methyloxazoline) successfully encapsulated the photosensitizer Rose Bengal-bovine serum albumin conjugate (RB-BSA) during a self-assembly process, as demonstrated by UV-Vis spectroscopy. A combination of light scattering and transmission electron microscopy indicated that the nanoreactors are stable over time. They serve a dual role: protecting the photosensitizer in the inner cavity and producing in situ reactive oxygen species (ROS) upon irradiation with appropriate electromagnetic radiation. Illumination with appropriate wavelength light allows us to switch on/off and to control the production of ROS. Because of the oxygen-permeable nature of the polymer membrane of vesicles, ROS escape into the environment around vesicles, as established by electron paramagnetic resonance. The light-sensitive nanoreactor is taken up by HeLa cells in a Trojan horse fashion: it is nontoxic and, when irradiated with the appropriate laser light, produces ROS that induce cell death in a precise area corresponding to the irradiation zone. These nanoreactors can be used in theranostic approaches because they can be detected via the fluorescent photosensitizer signal and simultaneously produce ROS efficiently ``on demand''.Various domains present the challenges of responding to stimuli in a specific manner, with the desired sensitivity or functionality, and only when required. Stimuli-responsive systems that are appropriately designed can effectively meet these challenges. Here, we introduce nanoreactors that

  1. 29 CFR 2.23 - Procedure where a decision concerning a demand is not made prior to the time a response to the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Procedure where a decision concerning a demand is not made prior to the time a response to the demand is required. 2.23 Section 2.23 Labor Office of the Secretary... concerning a demand is not made prior to the time a response to the demand is required. If the response...

  2. Culturally responsive middle school science: A case study of needs, demands, and challenges

    NASA Astrophysics Data System (ADS)

    Woodrow, Kelli Ellen

    2007-12-01

    Culturally responsive programming has been proposed as a remedy for the well-documented disconnect between schools and the ethnically and culturally diverse students who attend them. These programs often focus on creating instructional materials and pedagogical practices that are aligned with the knowledges, perspectives and practices of these students. This study builds on that literature and examines the needs, demands, and challenges of developing a culturally responsive health science program for ethnically and culturally diverse urban middle school students. I approached this problem through a content analysis of the intended curriculum and a microethnography of the enacted curriculum. In my analysis of the intended curriculum, I adapted a science textbook analysis instrument created by the American Association for the Advancement of Science (AAAS) to include criteria related to identified features of culturally responsive education. Using these modified analytic criteria, I found that the pilot drafts of the curricular materials excelled in the areas of engaging students in relevant phenomenon but lacked many of these specifically culturally responsive elements. Recommendations were made to redress these deficiencies. In my analysis of the enacted curriculum, I observed in five eighth grade classrooms where the program was being implemented. I used participant observation, audio and video tape recordings, artifacts, and interviews over a six-month period to investigate teacher/student interactions, the social organization of the classrooms, and students' culturally distinctive knowledge resources---or what is sometimes referred to as their "funds of knowledge." I found that the affective interactions between teachers and students were precursors to any reform, and that students and teachers similarly defined these interactions as "teacher care." In addition, I found that the social organization of the classroom often privileged official content and ways of

  3. 29 CFR 1610.34 - Procedure in the event of a demand for production or disclosure.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OPPORTUNITY COMMISSION AVAILABILITY OF RECORDS Production in Response to Subpenas or Demands of Courts or... replies to or appears before the court or other authority. (b) If response to the demand is required... 29 Labor 4 2010-07-01 2010-07-01 false Procedure in the event of a demand for production...

  4. 10 CFR 202.25 - Procedure where a decision concerning a demand is not made prior to the time a response to the...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Procedure where a decision concerning a demand is not made prior to the time a response to the demand is required. 202.25 Section 202.25 Energy DEPARTMENT OF ENERGY OIL PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Production or Disclosure in Response to Subpoenas or Demands of Courts or...

  5. Near-infrared light-responsive composite microneedles for on-demand transdermal drug delivery.

    PubMed

    Chen, Mei-Chin; Ling, Ming-Hung; Wang, Kuan-Wen; Lin, Zhi-Wei; Lai, Bo-Hung; Chen, Dong-Hwang

    2015-05-11

    This study presents near-infrared (NIR) light-responsive polymer-nanostructure composite microneedles used for on-demand transdermal drug delivery. Silica-coated lanthanum hexaboride (LaB6@SiO2) nanostructures were incorporated into polycaprolactone microneedles, serving as an NIR absorber. When the microneedles were irradiated with NIR light, light-to-heat transduction mediated by the LaB6@SiO2 nanostructures caused the microneedle melting at 50 °C. This increased the mobility of the polymer chains, enabling drug release from the matrix. Drug release from the microneedles was evaluated for four laser on/off cycles. In each cycle, the samples were irradiated until the temperature reached 50 °C for 3 min (laser on); the laser was then turned off for 30 min (laser off). The results showed that light-induced phase transition in the polymer triggered drug release from the melted microneedles. A stepwise drug-release behavior was observed after multiple cycles of NIR light exposure. No notable drug leakage was found in the off state. This NIR-light-triggerable device exhibits excellent reproducibility, low off-state leakage, and noninvasive triggerability and, thus, represents an advance in transdermal delivery technology.

  6. Important Factors for Early Market Microgrids: Demand Response and Plug-in Electric Vehicle Charging

    NASA Astrophysics Data System (ADS)

    White, David Masaki

    Microgrids are evolving concepts that are growing in interest due to their potential reliability, economic and environmental benefits. As with any new concept, there are many unresolved issues with regards to planning and operation. In particular, demand response (DR) and plug-in electric vehicle (PEV) charging are viewed as two key components of the future grid and both will likely be active technologies in the microgrid market. However, a better understanding of the economics associated with DR, the impact DR can have on the sizing of distributed energy resource (DER) systems and how to accommodate and price PEV charging is necessary to advance microgrid technologies. This work characterizes building based DR for a model microgrid, calculates the DER systems for a model microgrid under DR through a minimization of total cost, and determines pricing methods for a PEV charging station integrated with an individual building on the model microgrid. It is shown that DR systems which consist only of HVAC fan reductions provide potential economic benefits to the microgrid through participation in utility DR programs. Additionally, peak shaving DR reduces the size of power generators, however increasing DR capacity does not necessarily lead to further reductions in size. As it currently stands for a microgrid that is an early adopter of PEV charging, current installation costs of PEV charging equipment lead to a system that is not competitive with established commercial charging networks or to gasoline prices for plug-in hybrid electric vehicles (PHEV).

  7. Developing Gis-Based Demand-Responsive Transit System in Tehran City

    NASA Astrophysics Data System (ADS)

    Faroqi, H.; Sadeghi-Niaraki, A.

    2015-12-01

    Create, maintain and development of public transport network in metropolitan are important problems in the field of urban transport management. In public transport, maximize the efficient use of public fleet capacity has been considered. Concepts and technologies of GIS have provided suitable way for management and optimization of the public transports systems. In demand-responsive public transportation system, firstly fellow traveller groups have been established for applicants based on spatial concepts and tools of GIS, second for each group according to its' members and their paths, a public vehicle has been allocated to them then based on dynamic routing, the fellow passenger group has been gathered from their origins and has been moved to their destinations through optimal route. The suggested system has been implemented based on network data and commuting trips statistics of 1 to 6 districts in Tehran city. Evaluation performed on the results show the 34% increase using of Taxi capacity, 13% increase using of Van capacity and 10% increase using of Bus capacity in comparison between current public transport system and suggested public transportation system has been improved.

  8. Energy efficiency options for the New England Demand Response Initiative (NEDRI) -- Framing paper No.4

    SciTech Connect

    Schlegel, Jeff

    2002-05-01

    In response to direction from the Connecticut Department of Public Utility Control (DPUC) in Docket 99-09-30, the Connecticut Light and Power Company (CL&P) has assessed the role of third parties (e.g., ESCOs) in its current energy efficiency programs as well as additional opportunities for third parties to participate in future programs. In addition to working with consultants to the Energy Conservation Management Board, CL&P asked an independent consultant to develop a descriptive framework (i.e., typology) that summarizes alternative approaches to using third parties in ratepayer-funded energy efficiency programs. For each approach, experiences of energy efficiency program administrators (EEA) in other states are summarized, major policy objectives and goals that motivated regulators or EEAs to pursue that option are identified, and lessons learned (e.g., strengths and weaknesses) are summarized. Existing program offerings of CL&P are then classified using this typology in order to characterize the current situation in Connecticut and the potential implications for Connecticut's energy efficiency programs are discussed.

  9. Growth in Malaysian Demand for Business Education--the Australian Response.

    ERIC Educational Resources Information Center

    Lewis, Philip E. T.; Pratt, Graham R.

    1996-01-01

    Increasing Malaysian demand for business education is examined from the perspective of Australia, one of the largest suppliers to the region. Topics discussed include: origins and nature of the demand; Malaysian enrollment patterns in Australia; "twinning programs," in which a Malaysian college and a foreign university collaborate to meet such…

  10. Physics-based simulation of the impact of demand response on lead-acid emergency power availability in a datacenter

    NASA Astrophysics Data System (ADS)

    Mamun, A.; Wang, D.; Narayanan, I.; Sivasubramaniam, A.; Fathy, H. K.

    2015-02-01

    This paper uses a one-dimensional, physics-based model of a valve-regulated lead-acid (VRLA) battery to examine the impact of demand response on uninterruptible power supply (UPS) availability in a datacenter. Datacenters are facilities that provide services such as cloud computing, web search, etc. They are also large electricity consumers. An energy-efficient 15 MW datacenter, for instance, may pay 1 m per month for electricity. Datacenters often utilize VRLA batteries to ensure high reliability in serving their computational demand. This motivates the paper's central question: to what extent does the use of datacenter UPS batteries for demand response affect their availability for their primary purpose (namely, emergency power)? We address this question using a physics-based model of the coupled diffusion-reaction dynamics of VRLA batteries. We discretize this model using finite differences, and simulate it for different datacenter battery pack sizes. The results show that for a typical datacenter power demand profile, a VRLA battery pack sized for UPS functionality can provide demand response with only a minimal loss of UPS availability.

  11. Parallel high-performance grid computing: capabilities and opportunities of a novel demanding service and business class allowing highest resource efficiency.

    PubMed

    Kepper, Nick; Ettig, Ramona; Dickmann, Frank; Stehr, Rene; Grosveld, Frank G; Wedemann, Gero; Knoch, Tobias A

    2010-01-01

    Especially in the life-science and the health-care sectors the huge IT requirements are imminent due to the large and complex systems to be analysed and simulated. Grid infrastructures play here a rapidly increasing role for research, diagnostics, and treatment, since they provide the necessary large-scale resources efficiently. Whereas grids were first used for huge number crunching of trivially parallelizable problems, increasingly parallel high-performance computing is required. Here, we show for the prime example of molecular dynamic simulations how the presence of large grid clusters including very fast network interconnects within grid infrastructures allows now parallel high-performance grid computing efficiently and thus combines the benefits of dedicated super-computing centres and grid infrastructures. The demands for this service class are the highest since the user group has very heterogeneous requirements: i) two to many thousands of CPUs, ii) different memory architectures, iii) huge storage capabilities, and iv) fast communication via network interconnects, are all needed in different combinations and must be considered in a highly dedicated manner to reach highest performance efficiency. Beyond, advanced and dedicated i) interaction with users, ii) the management of jobs, iii) accounting, and iv) billing, not only combines classic with parallel high-performance grid usage, but more importantly is also able to increase the efficiency of IT resource providers. Consequently, the mere "yes-we-can" becomes a huge opportunity like e.g. the life-science and health-care sectors as well as grid infrastructures by reaching higher level of resource efficiency.

  12. China's Rare Earth Supply Chain: Illegal Production, and Response to new Cerium Demand

    NASA Astrophysics Data System (ADS)

    Nguyen, Ruby Thuy; Imholte, D. Devin

    2016-07-01

    As the demand for personal electronic devices, wind turbines, and electric vehicles increases, the world becomes more dependent on rare earth elements. Given the volatile, Chinese-concentrated supply chain, global attempts have been made to diversify supply of these materials. However, the overall effect of supply diversification on the entire supply chain, including increasing low-value rare earth demand, is not fully understood. This paper is the first attempt to shed some light on China's supply chain from both demand and supply perspectives, taking into account different Chinese policies such as mining quotas, separation quotas, export quotas, and resource taxes. We constructed a simulation model using Powersim Studio that analyzes production (both legal and illegal), production costs, Chinese and rest-of-world demand, and market dynamics. We also simulated new demand of an automotive aluminum-cerium alloy in the US market starting from 2018. Results showed that market share of the illegal sector has grown since 2007-2015, ranging between 22% and 25% of China's rare earth supply, translating into 59-65% illegal heavy rare earths and 14-16% illegal light rare earths. There will be a shortage in certain light and heavy rare earths given three production quota scenarios and constant demand growth rate from 2015 to 2030. The new simulated Ce demand would require supply beyond that produced in China. Finally, we illustrate revenue streams for different ore compositions in China in 2015.

  13. China’s rare earth supply chain: Illegal production, and response to new cerium demand

    DOE PAGESBeta

    Nguyen, Ruby Thuy; Imholte, D. Devin

    2016-03-29

    As the demand for personal electronic devices, wind turbines, and electric vehicles increases, the world becomes more dependent on rare earth elements. Given the volatile, Chinese-concentrated supply chain, global attempts have been made to diversify supply of these materials. However, the overall effect of supply diversification on the entire supply chain, including increasing low-value rare earth demand, is not fully understood. This paper is the first attempt to shed some light on China’s supply chain from both demand and supply perspectives, taking into account different Chinese policies such as mining quotas, separation quotas, export quotas, and resource taxes. We constructedmore » a simulation model using Powersim Studio that analyzes production (both legal and illegal), production costs, Chinese and rest-of-world demand, and market dynamics. We also simulated new demand of an automotive aluminum-cerium alloy in the U.S. market starting from 2018. Results showed that market share of the illegal sector has grown since 2007 to 2015, ranging between 22% and 25% of China’s rare earth supply, translating into 59–65% illegal heavy rare earths and 14–16% illegal light rare earths. There would be a shortage in certain light and heavy rare earths given three production quota scenarios and constant demand growth rate from 2015 to 2030. The new simulated Ce demand would require supply beyond that produced in China. Lastly, we illustrated revenue streams for different ore compositions in China in 2015.« less

  14. A New Thermostat for Real-Time Price Demand Response: Cost, Comfort and Energy Impacts of Discrete-Time Control without Deadband

    SciTech Connect

    Chassin, David P.; Stoustrup, Jakob; Agathoklis, Pan; Djilali, Ned

    2015-10-01

    This paper presents a residential thermostat design that enables accurate aggregate load control systems for electricity demand response. The thermostat features a control strategy that can be modeled as a linear time-invariant system for short- term demand response signals from the utility. This control design maintains the same comfort and demand response characteristics of existing real-time price- responsive thermostats but gives rise to linear time-invariant models of aggregate load control and demand response, which facilitates the design of highly accurate load-based regulation services for electricity interconnections.

  15. Killing Two Birds with One Stone: Can Real-Time Pricing SupportRetail Competition and Demand Response?

    SciTech Connect

    Barbose, Galen; Bharvirkar, Ranjit; Goldman, Charles; Hopper,Nicole; Neenan, Bernie

    2006-04-25

    As retail choice states reach the end of their transitional, rate-cap periods, state regulators must decide what type of default supply service to provide to customers that have not switched to a competitive retail supplier. In a growing number of states, regulators have adopted real-time pricing (RTP) as the default service for large commercial and industrial (C&I) customers. Although this trend is driven chiefly by policy objectives related to retail competition, default service RTP may have the added benefit of stimulating demand response. To evaluate the potential role of RTP as a means to both ends--retail market development and demand response--we conducted a comprehensive review of experience with default RTP in the U.S. and examined the emergence of RTP as a product offering by competitive retail suppliers. Across the ten utilities with default RTP in place in 2005, between 5% and 35% of the applicable load remained on the rate. Based on interviews with competitive retailers, we find evidence to suggest that a comparable amount of load in these states has switched to hourly pricing arrangements with competitive retailers. Many customers on default or competitive hourly pricing are paying prices indexed to the real-time spot market, and thus have no advance knowledge of prices. Because the price responsiveness of customers under these conditions has yet to be formally analyzed, and relatively few efforts have been undertaken to help these customers become price responsive, the actual demand response impacts from hourly pricing in retail choice states remains largely an open question. However, we find that policymakers and other stakeholders in retail choice states have various strategies at their disposal to capture the potential demand response benefits from hourly pricing, while simultaneously supporting retail competition.

  16. Flexible Composition: MEG Evidence for the Deployment of Basic Combinatorial Linguistic Mechanisms in Response to Task Demands

    PubMed Central

    Bemis, Douglas K.; Pylkkänen, Liina

    2013-01-01

    The present study investigates whether a minimal manipulation in task demands can induce core linguistic combinatorial mechanisms to extend beyond the bounds of normal grammatical phrases. Using magnetoencephalography, we measured neural activity evoked by the processing of adjective-noun phrases in canonical (red cup) and reversed order (cup red). During a task not requiring composition (verification against a color blob and shape outline), we observed significant combinatorial activity during canonical phrases only – as indexed by minimum norm source activity localized to the left anterior temporal lobe at 200–250 ms(cf. [1], [2]). When combinatorial task demands were introduced (by simply combining the blob and outline into a single colored shape) we observed significant combinatorial activity during reversed sequences as well. These results demonstrate the first direct evidence that basic linguistic combinatorial mechanisms can be deployed outside of normal grammatical expressions in response to task demands, independent of changes in lexical or attentional factors. PMID:24069253

  17. Time-Lag in Responses of Birds to Atlantic Forest Fragmentation: Restoration Opportunity and Urgency.

    PubMed

    Uezu, Alexandre; Metzger, Jean Paul

    2016-01-01

    There are few opportunities to evaluate the relative importance of landscape structure and dynamics upon biodiversity, especially in highly fragmented tropical landscapes. Conservation strategies and species risk evaluations often rely exclusively on current aspects of landscape structure, although such limited assumptions are known to be misleading when time-lag responses occur. By relating bird functional-group richness to forest patch size and isolation in ten-year intervals (1956, 1965, 1978, 1984, 1993 and 2003), we revealed that birds with different sensitivity to fragmentation display contrasting responses to landscape dynamics in the Brazilian Atlantic Forest. For non-sensitive groups, there was no time-lag in response: the recent degree of isolation best explains their variation in richness, which likely relates to these species' flexibility to adapt to changes in landscape structure. However, for sensitive bird groups, the 1978 patch area was the best explanatory variable, providing evidence for a 25-year time-lag in response to habitat reduction. Time-lag was more likely in landscapes that encompass large patches, which can support temporarily the presence of some sensitive species, even when habitat cover is relatively low. These landscapes potentially support the most threatened populations and should be priorities for restoration efforts to avoid further species loss. Although time-lags provide an opportunity to counteract the negative consequences of fragmentation, it also reinforces the urgency of restoration actions. Fragmented landscapes will be depleted of biodiversity if landscape structure is only maintained, and not improved. The urgency of restoration action may be even higher in landscapes where habitat loss and fragmentation history is older and where no large fragment remained to act temporarily as a refuge.

  18. Time-Lag in Responses of Birds to Atlantic Forest Fragmentation: Restoration Opportunity and Urgency

    PubMed Central

    Uezu, Alexandre; Metzger, Jean Paul

    2016-01-01

    There are few opportunities to evaluate the relative importance of landscape structure and dynamics upon biodiversity, especially in highly fragmented tropical landscapes. Conservation strategies and species risk evaluations often rely exclusively on current aspects of landscape structure, although such limited assumptions are known to be misleading when time-lag responses occur. By relating bird functional-group richness to forest patch size and isolation in ten-year intervals (1956, 1965, 1978, 1984, 1993 and 2003), we revealed that birds with different sensitivity to fragmentation display contrasting responses to landscape dynamics in the Brazilian Atlantic Forest. For non-sensitive groups, there was no time-lag in response: the recent degree of isolation best explains their variation in richness, which likely relates to these species’ flexibility to adapt to changes in landscape structure. However, for sensitive bird groups, the 1978 patch area was the best explanatory variable, providing evidence for a 25-year time-lag in response to habitat reduction. Time-lag was more likely in landscapes that encompass large patches, which can support temporarily the presence of some sensitive species, even when habitat cover is relatively low. These landscapes potentially support the most threatened populations and should be priorities for restoration efforts to avoid further species loss. Although time-lags provide an opportunity to counteract the negative consequences of fragmentation, it also reinforces the urgency of restoration actions. Fragmented landscapes will be depleted of biodiversity if landscape structure is only maintained, and not improved. The urgency of restoration action may be even higher in landscapes where habitat loss and fragmentation history is older and where no large fragment remained to act temporarily as a refuge. PMID:26820548

  19. Reserve capacity of public and private hospitals in response to demand uncertainty.

    PubMed

    Rodriguez-Alvarez, Ana; Roibás, David; Wall, Alan

    2012-07-01

    A feature of hospitals is that they face uncertain demand for the services they offer. To cover fluctuations in demand, they need to maintain reserve service capacity in the form of beds, equipment, personnel, etc. to minimize the probability of excess queuing or turning away patients, creating a trade-off between reserve service capacity and economic costs. Using a simple theoretical framework, we show how the reserve capacity established depends on institutional characteristics that can affect the objective of the hospital. In particular, we show that private and public hospitals may provide different levels of reserve capacity. In an empirical application using a panel data set of Spanish hospitals over the period 1996-2006, we model reserve service capacity using a distance frontier approach. Our results show that private hospitals generally react to a lesser extent to demand uncertainty than public hospitals.

  20. Beyond Access and Supply: Youth-Led Strategies to Captivate Young People's Interest in and Demand for Youth Programs and Opportunities

    ERIC Educational Resources Information Center

    Saito, Rebecca N.

    2006-01-01

    Most people would probably agree that participation in quality youth programs and neighborhood-based, informal relationships and opportunities is a good thing for young people. The problem is that not nearly enough children and youth are engaged in these growth-enhancing opportunities. What can educators learn from young people about designing…

  1. Poetry for Children: Reverie and the Demand for the Teacher's Responsibility

    ERIC Educational Resources Information Center

    Bramberger, Andrea

    2012-01-01

    There are indications of a positive trend in education. International comparative investigations on academic achievement and longitudinal studies on life courses prove the need for and the importance of children's high intellectual knowledge. At the same time, new research initiatives and projects comply with the demand that aesthetic/cultural…

  2. Response to consumer demand for reduced-fat foods; multi-functional fat replacers

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The excessive dietary fat intake can result in health problems such as obesity and heart-related diseases, resulting in increased consumer demand for reduced fat foods. A number of food ingredients with fat-like functions have been developed as fat alternatives in the food industry. Especially, so...

  3. Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake.

    PubMed

    Mathew, Sweety; Krug, Susanne; Skurk, Thomas; Halama, Anna; Stank, Antonia; Artati, Anna; Prehn, Cornelia; Malek, Joel A; Kastenmüller, Gabi; Römisch-Margl, Werner; Adamski, Jerzy; Hauner, Hans; Suhre, Karsten

    2014-06-06

    High-throughput screening techniques that analyze the metabolic endpoints of biological processes can identify the contributions of genetic predisposition and environmental factors to the development of common diseases. Studies applying controlled physiological challenges can reveal dysregulation in metabolic responses that may be predictive for or associated with these diseases. However, large-scale epidemiological studies with well controlled physiological challenge conditions, such as extended fasting periods and defined food intake, pose logistic challenges. Culturally and religiously motivated behavioral patterns of life style changes provide a natural setting that can be used to enroll a large number of study volunteers. Here we report a proof of principle study conducted within a Muslim community, showing that a metabolomics study during the Holy Month of Ramadan can provide a unique opportunity to explore the pre-prandial and postprandial response of human metabolism to nutritional challenges. Up to five blood samples were obtained from eleven healthy male volunteers, taken directly before and two hours after consumption of a controlled meal in the evening on days 7 and 26 of Ramadan, and after an over-night fast several weeks after Ramadan. The observed increases in glucose, insulin and lactate levels at the postprandial time point confirm the expected physiological response to food intake. Targeted metabolomics further revealed significant and physiologically plausible responses to food intake by an increase in bile acid and amino acid levels and a decrease in long-chain acyl-carnitine and polyamine levels. A decrease in the concentrations of a number of phospholipids between samples taken on days 7 and 26 of Ramadan shows that the long-term response to extended fasting may differ from the response to short-term fasting. The present study design is scalable to larger populations and may be extended to the study of the metabolic response in defined patient

  4. Responses to changing multiple-use demands: New directions for water resource planning and management

    SciTech Connect

    Sale, M.J.; Wadlington, R.O.

    1994-06-01

    Abstracts of papers from the American Water Resources Association Spring Symposium are presented in this text. Topics discussed include: multiple-use demands on water resources; water quality; recreational water activities; management of water resources are described for the Tennessee, Missouri, Columbia, and Sacramento-San Joaquin Rivers; wetlands and drainage; erosion control; environmental transport of pollutants; multiobjective optimization; flood management; ground water assessment; and ground water issues. Individual papers are catalogued separately.

  5. Rapid Scientific Response as an Educational Opportunity Integrating Geoscience and Advanced Visualization

    NASA Astrophysics Data System (ADS)

    Oskin, M. E.; Kellogg, L. H.; Team, K.

    2014-12-01

    Natural disasters provide important opportunities to conduct original scientific research. We present the results of a graduate course at the University of California, Davis centered on rapid scientific response to the 24 August magnitude 6.0 South Napa earthquake. Students from both geoscience and computer visualization formed collaborative teams to conduct original research, choosing from diverse research topics including mapping of the surface rupture, both in the field and remotely, production and analysis of three-dimensional scans of offset features, topographic point-cloud differencing, identification and mapping of pre-historic earthquake scarps, analysis of geodetic data for pre-earthquake fault loading rate and modeling of finite fault offset, aftershock distribution, construction and 3D visualization of earth structure and seismic velocity models, shaking intensity from empirical models, and earthquake rupture simulation.

  6. 14 CFR 1263.107 - Procedure to be followed when response to a demand is required before the General Counsel or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... demand is required before the General Counsel or designate has reached a final decision. If a response to... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Procedure to be followed when response to a demand is required before the General Counsel or designate has reached a final decision. 1263.107...

  7. Heart rate variability and cognitive processing: The autonomic response to task demands.

    PubMed

    Luque-Casado, Antonio; Perales, José C; Cárdenas, David; Sanabria, Daniel

    2016-01-01

    This study investigated variations in heart rate variability (HRV) as a function of cognitive demands. Participants completed an execution condition including the psychomotor vigilance task, a working memory task and a duration discrimination task. The control condition consisted of oddball versions (participants had to detect the rare event) of the tasks from the execution condition, designed to control for the effect of the task parameters (stimulus duration and stimulus rate) on HRV. The NASA-TLX questionnaire was used as a subjective measure of cognitive workload across tasks and conditions. Three major findings emerged from this study. First, HRV varied as a function of task demands (with the lowest values in the working memory task). Second, and crucially, we found similar HRV values when comparing each of the tasks with its oddball control equivalent, and a significant decrement in HRV as a function of time-on-task. Finally, the NASA-TLX results showed larger cognitive workload in the execution condition than in the oddball control condition, and scores variations as a function of task. Taken together, our results suggest that HRV is highly sensitive to overall demands of sustained attention over and above the influence of other cognitive processes suggested by previous literature. In addition, our study highlights a potential dissociation between objective and subjective measures of mental workload, with important implications in applied settings.

  8. Cell division responsive peptides for optimized plasmid DNA delivery: the mitotic window of opportunity?

    PubMed

    Remaut, K; Symens, N; Lucas, B; Demeester, J; De Smedt, S C

    2014-04-10

    The delivery of plasmid DNA remains hard to achieve, especially due to the presence of the nuclear membrane barrier. During cell division, however, the nuclear membrane is temporarily disassembled. We evaluated two different strategies to optimize plasmid DNA delivery in dividing cells: 1) phosphorylation responsive peptides that release plasmid DNA preferentially during mitosis and 2) chromatin targeting peptides to anchor plasmid DNA in newly formed nuclei upon cell division. Peptide/DNA particles alone were not efficient in penetrating cells. Upon co-delivery with lipid-based carriers, however, transfection efficiency drastically improved when compared to controls. For the phosphorylation responsive peptides, the presence of the phosphorylation sequence slightly increased transfection efficiency. For the chromatin targeting peptides, however, the chromatin targeting sequence did not seem to be the main reason for the improvement of transfection efficiency when applied in living cells. In conclusion, the pre-condensation of plasmid DNA with peptides improves lipid based delivery, but the nature of the peptides (cell responsive or not) does not seem to be the main reason for the improvement. It seems that the nuclear entry of foreign plasmid DNA is still under tight control, even during the mitotic window of opportunity.

  9. The A B Cs of Welfare Reform: A Guide to the Personal Responsibility and Work Opportunity Reconciliation Act of 1996.

    ERIC Educational Resources Information Center

    Sullivan, Candace J.; Sugarman, Jule M.

    The passage of the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 means that, for the first time, the federal government has shifted substantial responsibility for maintaining a social safety net for the most vulnerable populations to the state governments. This guide summarizes the contents of the new law, identifies…

  10. Learning-Focused Leadership in Urban High Schools: Response to Demanding Environments

    ERIC Educational Resources Information Center

    Knapp, Michael S.; Feldman, Susan; Yeh, Theresa Ling

    2013-01-01

    This article traces how the work of instructional leadership in the urban high school embodies a response to particular pressures in the school's environment. Based on evidence from multiple-case study research in four urban districts, the article demonstrates how supervisory and nonsupervisory leaders fashioned responses to the district (and…

  11. Processing Demand and Short-Term Memory: The Response-Prefix Effect

    ERIC Educational Resources Information Center

    Jahnke, John C.; Nowaczyk, Ronald H.

    1977-01-01

    Seven-digit strings were presented for immediate recall. Before recall, subjects either read or retrieved from memory a single item (response prefix). Results were seen in terms of the sharing of the limited capacity of an active memory system by the memory series, the response prefix, and the operations to retrieve and emit the items. (Editor/RK)

  12. Cephalopod-inspired design of electro-mechano-chemically responsive elastomers for on-demand fluorescent patterning.

    PubMed

    Wang, Qiming; Gossweiler, Gregory R; Craig, Stephen L; Zhao, Xuanhe

    2014-09-16

    Cephalopods can display dazzling patterns of colours by selectively contracting muscles to reversibly activate chromatophores--pigment-containing cells under their skins. Inspired by this novel colouring strategy found in nature, we design an electro-mechano-chemically responsive elastomer system that can exhibit a wide variety of fluorescent patterns under the control of electric fields. We covalently couple a stretchable elastomer with mechanochromic molecules, which emit strong fluorescent signals if sufficiently deformed. We then use electric fields to induce various patterns of large deformation on the elastomer surface, which displays versatile fluorescent patterns including lines, circles and letters on demand. Theoretical models are further constructed to predict the electrically induced fluorescent patterns and to guide the design of this class of elastomers and devices. The material and method open promising avenues for creating flexible devices in soft/wet environments that combine deformation, colorimetric and fluorescent response with topological and chemical changes in response to a single remote signal.

  13. Cephalopod-inspired design of electro-mechano-chemically responsive elastomers for on-demand fluorescent patterning

    NASA Astrophysics Data System (ADS)

    Wang, Qiming; Gossweiler, Gregory R.; Craig, Stephen L.; Zhao, Xuanhe

    2014-09-01

    Cephalopods can display dazzling patterns of colours by selectively contracting muscles to reversibly activate chromatophores - pigment-containing cells under their skins. Inspired by this novel colouring strategy found in nature, we design an electro-mechano-chemically responsive elastomer system that can exhibit a wide variety of fluorescent patterns under the control of electric fields. We covalently couple a stretchable elastomer with mechanochromic molecules, which emit strong fluorescent signals if sufficiently deformed. We then use electric fields to induce various patterns of large deformation on the elastomer surface, which displays versatile fluorescent patterns including lines, circles and letters on demand. Theoretical models are further constructed to predict the electrically induced fluorescent patterns and to guide the design of this class of elastomers and devices. The material and method open promising avenues for creating flexible devices in soft/wet environments that combine deformation, colorimetric and fluorescent response with topological and chemical changes in response to a single remote signal.

  14. 29 CFR 1610.34 - Procedure in the event of a demand for production or disclosure.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OPPORTUNITY COMMISSION AVAILABILITY OF RECORDS Production in Response to Subpenas or Demands of Courts or... replies to or appears before the court or other authority. (b) If response to the demand is required... furnish the court or other authority with a copy of the regulations contained in this part and inform...

  15. 12 CFR 404.32 - Procedure in the event a decision concerning a demand is not made prior to the time a response to...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Procedure in the event a decision concerning a demand is not made prior to the time a response to the demand is required. 404.32 Section 404.32 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES INFORMATION DISCLOSURE Demands for Testimony of Current and Former Ex-Im Bank Personnel and...

  16. 12 CFR 404.32 - Procedure in the event a decision concerning a demand is not made prior to the time a response to...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Procedure in the event a decision concerning a demand is not made prior to the time a response to the demand is required. 404.32 Section 404.32 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES INFORMATION DISCLOSURE Demands for Testimony of Current and Former Ex-Im Bank Personnel and...

  17. Power management and frequency regulation for microgrid and smart grid: A real-time demand response approach

    NASA Astrophysics Data System (ADS)

    Pourmousavi Kani, Seyyed Ali

    Future power systems (known as smart grid) will experience a high penetration level of variable distributed energy resources to bring abundant, affordable, clean, efficient, and reliable electric power to all consumers. However, it might suffer from the uncertain and variable nature of these generations in terms of reliability and especially providing required balancing reserves. In the current power system structure, balancing reserves (provided by spinning and non-spinning power generation units) usually are provided by conventional fossil-fueled power plants. However, such power plants are not the favorite option for the smart grid because of their low efficiency, high amount of emissions, and expensive capital investments on transmission and distribution facilities, to name a few. Providing regulation services in the presence of variable distributed energy resources would be even more difficult for islanded microgrids. The impact and effectiveness of demand response are still not clear at the distribution and transmission levels. In other words, there is no solid research reported in the literature on the evaluation of the impact of DR on power system dynamic performance. In order to address these issues, a real-time demand response approach along with real-time power management (specifically for microgrids) is proposed in this research. The real-time demand response solution is utilized at the transmission (through load-frequency control model) and distribution level (both in the islanded and grid-tied modes) to provide effective and fast regulation services for the stable operation of the power system. Then, multiple real-time power management algorithms for grid-tied and islanded microgrids are proposed to economically and effectively operate microgrids. Extensive dynamic modeling of generation, storage, and load as well as different controller design are considered and developed throughout this research to provide appropriate models and simulation

  18. Market transformation lessons learned from an automated demand response test in the Summer and Fall of 2003

    SciTech Connect

    Shockman, Christine; Piette, Mary Ann; ten Hope, Laurie

    2004-08-01

    A recent pilot test to enable an Automatic Demand Response system in California has revealed several lessons that are important to consider for a wider application of a regional or statewide Demand Response Program. The six facilities involved in the site testing were from diverse areas of our economy. The test subjects included a major retail food marketer and one of their retail grocery stores, financial services buildings for a major bank, a postal services facility, a federal government office building, a state university site, and ancillary buildings to a pharmaceutical research company. Although these organizations are all serving diverse purposes and customers, they share some underlying common characteristics that make their simultaneous study worthwhile from a market transformation perspective. These are large organizations. Energy efficiency is neither their core business nor are the decision makers who will enable this technology powerful players in their organizations. The management of buildings is perceived to be a small issue for top management and unless something goes wrong, little attention is paid to the building manager's problems. All of these organizations contract out a major part of their technical building operating systems. Control systems and energy management systems are proprietary. Their systems do not easily interact with one another. Management is, with the exception of one site, not electronically or computer literate enough to understand the full dimensions of the technology they have purchased. Despite the research team's development of a simple, straightforward method of informing them about the features of the demand response program, they had significant difficulty enabling their systems to meet the needs of the research. The research team had to step in and work directly with their vendors and contractors at all but one location. All of the participants have volunteered to participate in the study for altruistic reasons, that

  19. ROS-Responsive Microspheres for On Demand Antioxidant Therapy in a Model of Diabetic Peripheral Arterial Disease

    PubMed Central

    Poole, KM; Nelson, CE; Joshi, RV; Martin, JR; Gupta, MK; Haws, SC; Kavanaugh, TE; Skala, MC; Duvall, CL

    2014-01-01

    A new microparticle-based delivery system was synthesized from reactive oxygen species (ROS)-responsive poly(propylene sulfide) (PPS) and tested for “on demand” antioxidant therapy. PPS is hydrophobic but undergoes a phase change to become hydrophilic upon oxidation and thus provides a useful platform for ROS-demanded drug release. This platform was tested for delivery of the promising anti-inflammatory and antioxidant therapeutic molecule curcumin, which is currently limited in use in its free form due to poor pharmacokinetic properties. PPS microspheres efficiently encapsulated curcumin through oil-in-water emulsion and provided sustained, on demand release that was modulated in vitro by hydrogen peroxide concentration. The cytocompatible, curcumin-loaded microspheres preferentially targeted and scavenged intracellular ROS in activated macrophages, reduced in vitro cell death in the presence of cytotoxic levels of ROS, and decreased tissue-level ROS in vivo in the diabetic mouse hind limb ischemia model of peripheral arterial disease. Interestingly, due to the ROS scavenging behavior of PPS, the blank microparticles also showed inherent therapeutic properties that were synergistic with the effects of curcumin in these assays. Functionally, local delivery of curcumin-PPS microspheres accelerated recovery from hind limb ischemia in diabetic mice, as demonstrated using non-invasive imaging techniques. This work demonstrates the potential for PPS microspheres as a generalizable vehicle for ROS-demanded drug release and establishes the utility of this platform for improving local curcumin bioavailability for treatment of chronic inflammatory diseases. PMID:25522975

  20. Opportunities and Challenges for Women Engineers in Industry.

    ERIC Educational Resources Information Center

    O'Brien, J. Edwin

    There are real opportunities for women in engineering, reflecting demands created by the dramatic rate of change in society. Increasingly complex technology, fast response time, the demands of production and managerial positions, increased levels of education and sophistication of employees, shifts in motivational needs, and new organizational…

  1. Electricity for groundwater use: constraints and opportunities for adaptive response to climate change

    NASA Astrophysics Data System (ADS)

    Scott, Christopher A.

    2013-09-01

    Globally, groundwater use is intensifying to meet demands for irrigation, urban supply, industrialization, and, in some instances, electrical power generation. In response to hydroclimatic variability, surface water is being substituted with groundwater, which must be viewed as a strategic resource for climate adaptation. In this sense, the supply of electricity for pumping is an adaptation policy tool. Additionally, planning for climate-change mitigation must consider CO2 emissions resulting from pumping. This paper examines the influence of electricity supply and pricing on groundwater irrigation and resulting emissions, with specific reference to Mexico—a climate-water-energy ‘perfect storm’. Night-time power supply at tariffs below the already-subsidized rates for agricultural groundwater use has caused Mexican farmers to increase pumping, reversing important water and electricity conservation gains achieved. Indiscriminate groundwater pumping, including for virtual water exports of agricultural produce, threatens the long-term sustainability of aquifers, non-agricultural water uses, and stream-aquifer interactions that sustain riparian ecosystems. Emissions resulting from agricultural groundwater pumping in Mexico are estimated to be 3.6% of total national emissions and are equivalent to emissions from transporting the same agricultural produce to market. The paper concludes with an assessment of energy, water, and climate trends coupled with policy futures to address these challenges.

  2. Machine to machine (M2M) technology in demand responsive commercial buildings

    SciTech Connect

    Watson, David S.; Piette, Mary Ann; Sezgen, Osman; Motegi, Naoya; ten Hope, Laurie

    2004-08-01

    Machine to Machine (M2M) is a term used to describe the technologies that enable computers, embedded processors, smart sensors, actuators and mobile devices to communicate with one another, take measurements and make decisions--often without human intervention. M2M technology was applied to five commercial buildings in a test. The goal was to reduce electric demand when a remote price signal rose above a predetermine price. In this system, a variable price signal was generated from a single source on the Internet and distributed using the meta-language, XML (Extensible Markup Language). Each of five commercial building sites monitored the common price signal and automatically shed site-specific electric loads when the price increased above predetermined thresholds. Other than price signal scheduling, which was set up in advance by the project researchers, the system was designed to operate without human intervention during the two-week test period. Although the buildings responded to the same price signal, the communication infrastructures used at each building were substantially different. This study provides an overview of the technologies used at each building site, the price generator/server, and each link in between. Network architecture, security, data visualization and site-specific system features are characterized. The results of the test are discussed, including: functionality at each site, measurement and verification techniques, and feedback from energy managers and building operators. Lessons learned from the test and potential implications for widespread rollout are provided.

  3. [Demand for abortion and responses between the vote of the French law and its application].

    PubMed

    Geraud, R

    1975-01-01

    The abortion law has not been passed yet but there is a general fermentation and legal pressure around it. There are 2 main contradictory opinions: some people think that the patient should prescribe herself her own therapeutics and the medical staff has the obligation to execute them, which means and antimedical solution. Others think that the medical staff can prescribe and execute. Both attitudes are unacceptable; the decision should be based on objective facts. The demand for aboriton has increased considerably in the last 2 years largely due to improper information on contraceptives. Television should be used for the dissemination and education on contraception. Too much has been written about abortion by politicians, theologians, philosophers, and journalists, while the medical specialists can hardly publish an objective article on aboriton in a reputable magazine. However, while controversy is stimulating for the medical staff, it is the patients who suffer the consequences. Therefore a solution of the problem is mandatory. The people should be informed and educated before a logical solution can be adopted.

  4. Ecology and vegetarian considerations: does environmental responsibility demand the elimination of livestock?

    PubMed

    Gussow, J D

    1994-05-01

    Although the recommendation to avoid animal flesh for environmental reasons has been increasingly advanced, especially in the highly industrialized countries, the ecological implications of such avoidance are seldom carefully examined. If sustainable food systems are to be modeled after natural systems that maintain fertility, both plants and animals would be involved. This paper examines the history of the idea that environmental responsibility is linked to vegetarianism and the destructive effects of present methods of animal raising on farmers, animal welfare, and the environment. Finally, it explores the question of whether vegetarianism is the appropriate response to these problems.

  5. 19 CFR 103.24 - Procedure in the event a decision concerning a demand is not made prior to the time a response to...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Procedure in the event a decision concerning a demand is not made prior to the time a response to the demand is required. 103.24 Section 103.24 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AVAILABILITY OF INFORMATION Production...

  6. Job demands and resting and napping opportunities for nurses during night shifts: impact on sleepiness and self-evaluated quality of healthcare

    PubMed Central

    BARTHE, Béatrice; TIRILLY, Ghislaine; GENTIL, Catherine; TOUPIN, Cathy

    2015-01-01

    The aim of this field study is to describe night shift resting and napping strategies and to examine their beneficial effects on sleepiness and quality of work. The study was carried out with 16 nurses working in an intensive care unit. Data collected during 20 night shifts were related to job demands (systematic observations), to the duration and timing of rests and naps taken by nurses (systematic observations, sleep diaries), to sleepiness (Karolinska Sleepiness Scale), and to quality of work scores (visual analog scale). The results showed that the number of rests and naps depended on the job demands. Resting and napping lowered the levels of sleepiness at the end of the shift. There was no direct relationship between sleepiness and the quality of work score. Discussions about the choice of indicators for the quality of work are necessary. Suggestions for implementing regulations for prescribed napping during night shifts are presented. PMID:26537999

  7. The Responsiveness of the Demand for Condoms to the Local Prevalence of AIDS.

    ERIC Educational Resources Information Center

    Ahituv, Avner; And Others

    1996-01-01

    National Longitudinal Survey of Youth 1979 data show that use of condoms is related to the prevalence of AIDS in one's state of residence. A 1% increase in AIDS increases condom use significantly, up to 50% for groups most responsive to prevalence (men, urban residents, single). (SK)

  8. To Resist, Acquiesce, or Internalize: Departmental Responsiveness to Demands for Outcomes Assessment

    ERIC Educational Resources Information Center

    Young, Candace C.; Cartwright, Debra K.; Rudy, Michael

    2014-01-01

    Over the last 30 years, higher education has received the assessment movement with a substantial amount of skepticism. The purpose of this study is to advance our understanding of political science's responsiveness to assessment reform pressures using neoinstitutional theory. The influence of public status, institutional type, and…

  9. Photosynthetic response to low sink demand after fruit removal in relation to photoinhibition and photoprotection in peach trees.

    PubMed

    Duan, Wei; Fan, Pei G; Wang, Li J; Li, Wei D; Yan, Shu T; Li, Shao H

    2008-01-01

    Diurnal variations in photosynthesis, chlorophyll fluorescence, xanthophyll cycle, antioxidant enzymes and antioxidant metabolism in leaves in response to low sink demand caused by fruit removal (-fruit) were studied in 'Zaojiubao' peach (Prunus persica (L.) Batch) trees during the final stage of rapid fruit growth. Compared with the retained fruit treatment (+fruit), the -fruit treatment resulted in a significantly lower photosynthetic rate, stomatal conductance and transpiration rate, but generally higher internal CO(2) concentration, leaf-to-air vapor pressure difference and leaf temperature. The low photosynthetic rate in the -fruit trees paralleled reductions in maximal efficiency of photosystem II (PSII) photochemistry and carboxylation efficiency. The midday depression in photosynthetic rate in response to low sink demand resulting from fruit removal was mainly caused by non-stomatal limitation. Fruit removal resulted in lower quantum efficiency of PSII as a result of both a decrease in the efficiency of excitation capture by open PSII reaction centers and an increase in closure of PSII reaction centers. Both xanthophyll-dependent thermal dissipation and the antioxidant system were up-regulated providing protection from photo-oxidative damage to leaves during low sink demand. Compared with the leaves of +fruit trees, leaves of -fruit trees had a larger xanthophyll cycle pool size and a higher de-epoxidation state, as well as significantly higher activities of antioxidant enzymes, including superoxide dismutase, ascorbate peroxidase, monodehydroascorbate reductase, dehydroascorbate reductase, glutathione reductase and a higher reduction state of ascorbate and glutathione. However, the -fruit treatment resulted in higher hydrogen peroxide and malondialdehyde concentrations compared with the +fruit treatment, indicating photo-oxidative damage.

  10. Emerging Opportunities for School Psychologists to Enhance our Remediation Procedure Evidence Base as We Apply Response to Intervention

    ERIC Educational Resources Information Center

    Skinner, Christopher H.; McCleary, Daniel F.; Skolits, Gary L.; Poncy, Brian C.; Cates, Gary L.

    2013-01-01

    The success of Response-to-Intervention (RTI) and similar models of service delivery is dependent on educators being able to apply effective and efficient remedial procedures. In the process of implementing problem-solving RTI models, school psychologists have an opportunity to contribute to and enhance the quality of our remedial-procedure…

  11. Wheeled mobility device transportation safety in fixed route and demand-responsive public transit vehicles within the United States.

    PubMed

    Frost, Karen L; van Roosmalen, Linda; Bertocci, Gina; Cross, Douglas J

    2012-01-01

    An overview of the current status of wheelchair transportation safety in fixed route and demand-responsive, non-rail, public transportation vehicles within the US is presented. A description of each mode of transportation is provided, followed by a discussion of the primary issues affecting safety, accessibility, and usability. Technologies such as lifts, ramps, securement systems, and occupant restraint systems, along with regulations and voluntary industry standards have been implemented with the intent of improving safety and accessibility for individuals who travel while seated in their wheeled mobility device (e.g., wheelchair or scooter). However, across both fixed route and demand-responsive transit systems a myriad of factors such as nonuse and misuse of safety systems, oversized wheeled mobility devices, vehicle space constraints, and inadequate vehicle operator training may place wheeled mobility device (WhMD) users at risk of injury even under non-impact driving conditions. Since WhMD-related incidents also often occur during the boarding and alighting process, the frequency of these events, along with factors associated with these events are described for each transit mode. Recommendations for improving WhMD transportation are discussed given the current state of

  12. Physiological responses of mild pulmonary impaired subjects while using a demand respirator during rest and work

    SciTech Connect

    Raven, P.B.; Jackson, A.W.; Page, K.; Moss, R.F.; Bradley, O.; Skaggs, B.

    1981-04-01

    This investigation determined the cardiorespiratory responses of subjects with normal lung function and exercise tolerance and compared them with subjects with moderate and severe impairment of lung function and exercise tolerance. Comparisons were made during work while wearing an industrial respirator. Physiologically and subjectively the response of the normal and moderately impaired subjects to respirator wear during rest, 35%, 50% and 63% of their maximal workloads were not different. However, when the moderately impaired worked at 63% of their maximum the workload was equivalent to 50% of maximum of the normal subject. Significant differences in the peak flow/pressure ratio of the severely impaired compred to the normals and moderately impaired were found. By relating work performance to the dyspnea index it was suggested that the relationship between maximal lung function and maximal work performance needs to be identified both with and without respirators. This relationship may prove suitable in predicting performance during respirator wear.

  13. Cognitive load and autonomic response patterns under negative priming demand in depersonalization-derealization disorder.

    PubMed

    Lemche, Erwin; Sierra-Siegert, Mauricio; David, Anthony S; Phillips, Mary L; Gasston, David; Williams, Steven C R; Giampietro, Vincent P

    2016-04-01

    Previous studies have yielded evidence for cognitive processing abnormalities and alterations of autonomic functioning in depersonalization-derealization disorder (DPRD). However, multimodal neuroimaging and psychophysiology studies have not yet been conducted to test for functional and effective connectivity under cognitive stress in patients with DPRD. DPRD and non-referred control subjects underwent a combined Stroop/negative priming task, and the neural correlates of Stroop interference effect, negative priming effect, error rates, cognitive load span and average amplitude of skin conductance responses were ascertained for both groups. Evoked haemodynamic responses for basic Stroop/negative priming activations were compared. For basic Stroop to neutral contrast, patients with DPRD differed in the location (inferior vs. superior lobule) of the parietal region involved, but showed similar activations in the left frontal region. In addition, patients with DPRD also co-activated the dorsomedial prefrontal cortex (BA9) and posterior cingulate cortex (BA31), which were also found to be the main between-group difference regions. These regions furthermore showed connectivity with frequency of depersonalization states. Evoked haemodynamic responses drawn from regions of interest indicated significant between-group differences in 30-40% of time points. Brain-behaviour correlations differed mainly in laterality, yet only slightly in regions. A reversal of autonomic patterning became evident in patients with DPRD for cognitive load spans, indicating less effective arousal suppression under cognitive stress - patients with DPRD showed positive associations of cognitive load with autonomic responses, whereas controls exhibit respective inverse association. Overall, the results of the present study show only minor executive cognitive peculiarities, but further support the notion of abnormalities in autonomic functioning in patients with DPRD.

  14. 49 CFR 37.77 - Purchase or lease of new non-rail vehicles by public entities operating a demand responsive...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and days of service; (5) Restrictions or priorities based on trip purpose; (6) Availability of... disabilities. (c) For purposes of this section, a demand responsive system, when viewed in its entirety,...

  15. 49 CFR 37.77 - Purchase or lease of new non-rail vehicles by public entities operating a demand responsive...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... and days of service; (5) Restrictions or priorities based on trip purpose; (6) Availability of... disabilities. (c) For purposes of this section, a demand responsive system, when viewed in its entirety,...

  16. 49 CFR 37.77 - Purchase or lease of new non-rail vehicles by public entities operating a demand responsive...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and days of service; (5) Restrictions or priorities based on trip purpose; (6) Availability of... disabilities. (c) For purposes of this section, a demand responsive system, when viewed in its entirety,...

  17. Opportunity for offshore wind to reduce future demand for coal-fired power plants in China with consequent savings in emissions of CO2.

    PubMed

    Lu, Xi; McElroy, Michael B; Chen, Xinyu; Kang, Chongqing

    2014-12-16

    Although capacity credits for wind power have been embodied in power systems in the U.S. and Europe, the current planning framework for electricity in China continues to treat wind power as a nondispatchable source with zero contribution to firm capacity. This study adopts a rigorous reliability model for the electric power system evaluating capacity credits that should be recognized for offshore wind resources supplying power demands for Jiangsu, China. Jiangsu is an economic hub located in the Yangtze River delta accounting for 10% of the total electricity consumed in China. Demand for electricity in Jiangsu is projected to increase from 331 TWh in 2009 to 800 TWh by 2030. Given a wind penetration level of 60% for the future additional Jiangsu power supply, wind resources distributed along the offshore region of five coastal provinces in China (Shandong, Jiangsu, Shanghai, Zhejiang, and Fujian) should merit a capacity credit of 12.9%, the fraction of installed wind capacity that should be recognized to displace coal-fired systems without violating the reliability standard. In the high-coal-price scenario, with 60% wind penetration, reductions in CO2 emissions relative to a business as usual reference could be as large as 200.2 million tons of CO2 or 51.8% of the potential addition, with a cost for emissions avoided of $29.0 per ton. PMID:25409413

  18. Opportunity for offshore wind to reduce future demand for coal-fired power plants in China with consequent savings in emissions of CO2.

    PubMed

    Lu, Xi; McElroy, Michael B; Chen, Xinyu; Kang, Chongqing

    2014-12-16

    Although capacity credits for wind power have been embodied in power systems in the U.S. and Europe, the current planning framework for electricity in China continues to treat wind power as a nondispatchable source with zero contribution to firm capacity. This study adopts a rigorous reliability model for the electric power system evaluating capacity credits that should be recognized for offshore wind resources supplying power demands for Jiangsu, China. Jiangsu is an economic hub located in the Yangtze River delta accounting for 10% of the total electricity consumed in China. Demand for electricity in Jiangsu is projected to increase from 331 TWh in 2009 to 800 TWh by 2030. Given a wind penetration level of 60% for the future additional Jiangsu power supply, wind resources distributed along the offshore region of five coastal provinces in China (Shandong, Jiangsu, Shanghai, Zhejiang, and Fujian) should merit a capacity credit of 12.9%, the fraction of installed wind capacity that should be recognized to displace coal-fired systems without violating the reliability standard. In the high-coal-price scenario, with 60% wind penetration, reductions in CO2 emissions relative to a business as usual reference could be as large as 200.2 million tons of CO2 or 51.8% of the potential addition, with a cost for emissions avoided of $29.0 per ton.

  19. Moderating effects of salivary testosterone levels on associations between job demand and psychological stress response in Japanese medical workers.

    PubMed

    Hirokawa, Kumi; Miwa, Machiko; Taniguchi, Toshiyo; Tsuchiya, Masao; Kawakami, Norito

    2016-06-10

    Levels of job stress have been shown to be inversely associated with testosterone levels, but some inconsistent results have been documented. We investigated the moderating effects of testosterone levels on associations between job stress-factors and psychological stress responses in Japanese medical workers. The participants were 63 medical staff (20 males and 43 women; mean age: 30.6 years; SD=7.3) in Okayama, Japan. Their job-stress levels and psychological stress responses were evaluated using self-administered questionnaires, and their salivary testosterone collected. Multiple regression analyses showed that job demand was positively associated with stress responses in men and women. An interaction between testosterone and support from colleagues had a significant effect on depression and anxiety for women. In women with lower testosterone levels, a reducing effect of support from colleagues on depression and anxiety was intensified. In women with higher testosterone levels, depression and anxiety levels were identical regardless of support from colleagues. Testosterone may function as a moderator between perceived work environment and psychological stress responses for female medical workers.

  20. Compensatory structural adaptive modifications of vagina in response to functional demand in goat.

    PubMed

    Hussin, Amer M; Zaid, Nazih W; Hussain, S O

    2014-01-01

    Vaginal biopsies and smears were collected from ten adult local healthy goats. Routine histological methods were carried out on vaginal biopsies and then stained with PAS stain. The smears were stained with Methylene blue. All samples were inspected under light microscope. The present study found that many constituents of the wall of the vagina, which have an important functional role, were absent; among these were the vaginal glands, goblet cells, muscularis mucosa, and lymphatic nodules. On the other hand, vagina showed special compensatory histological mechanisms, namely, the deep epithelial folds, the well-developed germinated stratum basale, the apparent basement membrane, and the profuse defensive cells, such as neutrophils, macrophages, lymphocytes, plasma cells, and mast cells. The general stains of this study could not recognize dendritic cells although they play an important functional role. Moreover, the herein study declared also that the vaginal smears showing many adaptive cellular mechanisms among these were, the keratinization, the process of sheet formation that lines the vaginal lumen, the process of metachromasia which is related to the cellular activity in protein synthesis, keratin, and finally the presence of endogenous microorganisms. It was concluded that all the above cellular compensatory adaptive mechanisms may compensate the lacking vaginal constituents and act to raise the immune response of the vagina.

  1. Community-oriented primary care (COPC) and the affordable care act: an opportunity to meet the demands of an evolving health care system.

    PubMed

    Gofin, Jaime; Gofin, Rosa; Stimpson, Jim P

    2015-04-01

    Community-oriented primary care (COPC) is a model of health care delivery that tightly integrates primary care and public health. This model of care, applied around the globe, could be more widely adopted in the United States as clinical delivery systems respond to the growing demand for population health management, which has been driven largely by various provisions of the Affordable Care Act (ACA). For that purpose, there is need for changes in capacitating health professionals and changes in organizational structures that will address the needs and health priorities of the population, considering individual care management in the context of population health for a defined population. This article presents how the Affordable Care Act is an appropriate framework for COPC to succeed and the way forward to develop COPC through practical alternatives for the delivery of primary care within a population context.

  2. The Personal Responsibility and Work Opportunity Reconciliation Act of 1996: An Examination of Its Impact on Legal Immigrants and Refugees in Rhode Island.

    ERIC Educational Resources Information Center

    Serpa, Fernando A.

    This report describes a 1998 consultation conducted to examine the impact of the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 on legal immigrants and refugees in Rhode Island. The Personal Responsibility and Work Opportunity Act restricted access of documented immigrants to a wide range of government programs such as…

  3. Small-scale (flash) flood early warning in the light of operational requirements: opportunities and limits with regard to user demands, driving data, and hydrologic modeling techniques

    NASA Astrophysics Data System (ADS)

    Philipp, Andy; Kerl, Florian; Büttner, Uwe; Metzkes, Christine; Singer, Thomas; Wagner, Michael; Schütze, Niels

    2016-05-01

    In recent years, the Free State of Saxony (Eastern Germany) was repeatedly hit by both extensive riverine flooding, as well as flash flood events, emerging foremost from convective heavy rainfall. Especially after a couple of small-scale, yet disastrous events in 2010, preconditions, drivers, and methods for deriving flash flood related early warning products are investigated. This is to clarify the feasibility and the limits of envisaged early warning procedures for small catchments, hit by flashy heavy rain events. Early warning about potentially flash flood prone situations (i.e., with a suitable lead time with regard to required reaction-time needs of the stakeholders involved in flood risk management) needs to take into account not only hydrological, but also meteorological, as well as communication issues. Therefore, we propose a threefold methodology to identify potential benefits and limitations in a real-world warning/reaction context. First, the user demands (with respect to desired/required warning products, preparation times, etc.) are investigated. Second, focusing on small catchments of some hundred square kilometers, two quantitative precipitation forecasts are verified. Third, considering the user needs, as well as the input parameter uncertainty (i.e., foremost emerging from an uncertain QPF), a feasible, yet robust hydrological modeling approach is proposed on the basis of pilot studies, employing deterministic, data-driven, and simple scoring methods.

  4. Ongoing Activity in Temporally Coherent Networks Predicts Intra-Subject Fluctuation of Response Time to Sporadic Executive Control Demands

    PubMed Central

    Nozawa, Takayuki; Sugiura, Motoaki; Yokoyama, Ryoichi; Ihara, Mizuki; Kotozaki, Yuka; Miyauchi, Carlos Makoto; Kanno, Akitake; Kawashima, Ryuta

    2014-01-01

    Can ongoing fMRI BOLD signals predict fluctuations in swiftness of a person’s response to sporadic cognitive demands? This is an important issue because it clarifies whether intrinsic brain dynamics, for which spatio-temporal patterns are expressed as temporally coherent networks (TCNs), have effects not only on sensory or motor processes, but also on cognitive processes. Predictivity has been affirmed, although to a limited extent. Expecting a predictive effect on executive performance for a wider range of TCNs constituting the cingulo-opercular, fronto-parietal, and default mode networks, we conducted an fMRI study using a version of the color–word Stroop task that was specifically designed to put a higher load on executive control, with the aim of making its fluctuations more detectable. We explored the relationships between the fluctuations in ongoing pre-trial activity in TCNs and the task response time (RT). The results revealed the existence of TCNs in which fluctuations in activity several seconds before the onset of the trial predicted RT fluctuations for the subsequent trial. These TCNs were distributed in the cingulo-opercular and fronto-parietal networks, as well as in perceptual and motor networks. Our results suggest that intrinsic brain dynamics in these networks constitute “cognitive readiness,” which plays an active role especially in situations where information for anticipatory attention control is unavailable. Fluctuations in these networks lead to fluctuations in executive control performance. PMID:24901995

  5. Global climate change response program. Impacts of projected climate change on urban water use. An application using the Wasatch Front water demand and supply model. Final report

    SciTech Connect

    Hughes, T.; Wang, Y.M.; Hansen, R.

    1994-02-01

    Urban water use, particularly outdoor use, responds to changes in temperature, precipitation, and other climatic parameters. The study significantly improved the capacity of an existing regional water demand model to estimate the response of both residential and commercial-industrial water demand to changes in climatic parameters. The resulting functional relationships derived from historic time-series climatic and water use data were applied to global climate scenarios for the four Wasatch Front counties of Utah.

  6. 22 CFR 206.4 - Procedure where a decision concerning a demand is not made prior to the time a response to the...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Procedure where a decision concerning a demand is not made prior to the time a response to the demand is required. 206.4 Section 206.4 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT TESTIMONY BY EMPLOYEES AND THE PRODUCTION OF DOCUMENTS IN PROCEEDINGS WHERE A.I.D. IS NOT A PARTY §...

  7. Pancreatic β-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A.

    PubMed

    Song, Woo-Jin; Mondal, Prosenjit; Li, Yuanyuan; Lee, Suh Eun; Hussain, Mehboob A

    2013-08-01

    Incretin hormone action on β-cells stimulates in parallel two different intracellular cyclic AMP-dependent signaling branches mediated by protein kinase A and exchange protein activated by cAMP islet/brain isoform 2A (EPAC2A). Both pathways contribute toward potentiation of glucose-stimulated insulin secretion (GSIS). However, the overall functional role of EPAC2A in β-cells as it relates to in vivo glucose homeostasis remains incompletely understood. Therefore, we have examined in vivo GSIS in global EPAC2A knockout mice. Additionally, we have conducted in vitro studies of GSIS and calcium dynamics in isolated EPAC2A-deficient islets. EPAC2A deficiency does not impact GSIS in mice under basal conditions. However, when mice are exposed to diet-induced insulin resistance, pharmacologic secretagogue stimulation of β-cells with an incretin hormone glucagon-like peptide-1 analog or with a fatty acid receptor 1/G protein-coupled receptor 40 selective activator, EPAC2A is required for the increased β-cell response to secretory demand. Under these circumstances, EPAC2A is required for potentiating the early dynamic increase in islet calcium levels after glucose stimulation, which is reflected in potentiated first-phase insulin secretion. These studies broaden our understanding of EPAC2A function and highlight its significance during increased secretory demand or drive on β-cells. Our findings advance the rationale for developing EPAC2A-selective pharmacologic activators for β-cell-targeted pharmacotherapy in type 2 diabetes.

  8. Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A

    PubMed Central

    Song, Woo-Jin; Mondal, Prosenjit; Li, Yuanyuan; Lee, Suh Eun; Hussain, Mehboob A.

    2013-01-01

    Incretin hormone action on β-cells stimulates in parallel two different intracellular cyclic AMP-dependent signaling branches mediated by protein kinase A and exchange protein activated by cAMP islet/brain isoform 2A (EPAC2A). Both pathways contribute toward potentiation of glucose-stimulated insulin secretion (GSIS). However, the overall functional role of EPAC2A in β-cells as it relates to in vivo glucose homeostasis remains incompletely understood. Therefore, we have examined in vivo GSIS in global EPAC2A knockout mice. Additionally, we have conducted in vitro studies of GSIS and calcium dynamics in isolated EPAC2A-deficient islets. EPAC2A deficiency does not impact GSIS in mice under basal conditions. However, when mice are exposed to diet-induced insulin resistance, pharmacologic secretagogue stimulation of β-cells with an incretin hormone glucagon-like peptide-1 analog or with a fatty acid receptor 1/G protein–coupled receptor 40 selective activator, EPAC2A is required for the increased β-cell response to secretory demand. Under these circumstances, EPAC2A is required for potentiating the early dynamic increase in islet calcium levels after glucose stimulation, which is reflected in potentiated first-phase insulin secretion. These studies broaden our understanding of EPAC2A function and highlight its significance during increased secretory demand or drive on β-cells. Our findings advance the rationale for developing EPAC2A-selective pharmacologic activators for β-cell–targeted pharmacotherapy in type 2 diabetes. PMID:23578994

  9. Effect of language task demands on the neural response during lexical access: a functional magnetic resonance imaging study.

    PubMed

    Gan, Gabriela; Büchel, Christian; Isel, Frédéric

    2013-07-01

    This study examined the effects of linguistic task demands on the neuroanatomical localization of the neural response related to automatic semantic processing of concrete German nouns combining the associative priming paradigm with functional magnetic resonance imaging (fMRI). To clarify the functional role of the inferior frontal gyrus (IFG) for semantic processing with respect to semantic decision making compared to semantic processing per se, we used a linguistic task that involved either a binary decision process (i.e., semantic categorization; Experiment 1) or not (i.e., silently thinking about a word's meaning; Experiment 2). We observed associative priming effects indicated as neural suppression in bilateral superior temporal gyri (STG), anterior cingulate cortex (ACC), occipito-temporal brain areas, and in medial frontal brain areas independently of the linguistic task. Inferior parietal brain areas were more active for silently thinking about a word's meaning compared to semantic categorization. A conjunction analysis of linguistic task revealed that both tasks activated the same left-lateralized occipito-temporo-frontal network including the IFG. Contrasting neural associative priming effects across linguistic task demands, we found a significant interaction in the right IFG. The present fMRI data give rise to the assumption that activation of the left inferior frontal gyrus (LIFG) in the semantic domain might be important for semantic processing in general and not only for semantic decision making. These findings contrast with a recent study regarding the role of the LIFG for binary decision making in the lexical domain (Wright et al. 2011). PMID:24381811

  10. Balancing extensive ambition and a context overflowing with opportunities and demands: A grounded theory on stress and recovery among highly educated working young women entering male-dominated occupational areas.

    PubMed

    Löve, Jesper; Hagberg, Mats; Dellve, Lotta

    2011-01-01

    Several factors underline the issue of stress-related health among young highly educated women. Major societal changes might provide more new challenges with considerably changed and expanded roles than were expected by earlier generations, especially among women. The quantity of young women with higher education has also increased threefold in Sweden in less than two decades and there are a growing number of young women that hereby break with traditional gender positions and enter new occupational areas traditionally dominated by men. The research questions in the present study were: "What is the main concern, regarding stress and recovery, among young highly educated working women breaking with traditional gender positions and entering male-dominated occupational areas?" and "How do they handle this concern?" We conducted open-ended interviews with 20 informants, aged 23-29 years. The results showed that the synergy between highly ambitious individuals and a context overflowing with opportunities and demands ended up in the informants' constantly striving to find a balance in daily life (main concern). This concern refers to the respondents experiencing a constant overload of ambiguity and that they easily became entangled in a loop of stress and dysfunctional coping behavior, threatening the balance between stress and sufficient recovery. In order to handle this concern, the respondents used different strategies in balancing extensive ambition and a context overflowing with opportunities and demands (core category). This preliminary theoretical model deepens our understanding of how the increasing numbers of highly educated young women face complex living conditions endangering their possibility of maintaining health and work ability.

  11. Joint Real-Time Energy and Demand-Response Management using a Hybrid Coalitional-Noncooperative Game

    SciTech Connect

    He, Fulin; Gu, Yi; Hao, Jun; Zhang, Jun Jason; Wei, Jiaolong; Zhang, Yingchen

    2015-11-11

    In order to model the interactions among utility companies, building demands and renewable energy generators (REGs), a hybrid coalitional-noncooperative game framework has been proposed. We formulate a dynamic non-cooperative game to study the energy dispatch within multiple utility companies, while we take a coalitional perspective on REGs and buildings demands through a hedonic coalition formation game approach. In this case, building demands request different power supply from REGs, then the building demands can be organized into an ultimate coalition structure through a distributed hedonic shift algorithm. At the same time, utility companies can also obtain a stable power generation profile. In addition, the interactive progress among the utility companies and building demands which cannot be supplied by REGs is implemented by distributed game theoretic algorithms. Numerical results illustrate that the proposed hybrid coalitional-noncooperative game scheme reduces the cost of both building demands and utility companies compared with the initial scene.

  12. Employment Threat, Equality of Opportunities and Educators' Response to the Rapid Feminization of School Principalship.

    ERIC Educational Resources Information Center

    Chen, Michael; Addi, Audrey

    This paper examines the responses of men and women in the Israeli educational system toward the rapid feminization of school administration. Two theoretical perspectives--the "enlightened" approach and conflict theory--provide a framework for understanding the responses. Data were obtained from the responses to a questionnaire of 156 graduates of…

  13. On the Inclusion of Energy-Shifting Demand Response in Production Cost Models: Methodology and a Case Study

    SciTech Connect

    O'Connell, Niamh; Hale, Elaine; Doebber, Ian; Jorgenson, Jennie

    2015-07-20

    In the context of future power system requirements for additional flexibility, demand response (DR) is an attractive potential resource. Its proponents widely laud its prospective benefits, which include enabling higher penetrations of variable renewable generation at lower cost than alternative storage technologies, and improving economic efficiency. In practice, DR from the commercial and residential sectors is largely an emerging, not a mature, resource, and its actual costs and benefits need to be studied to determine promising combinations of physical DR resource, enabling controls and communications, power system characteristics, regulatory environments, market structures, and business models. The work described in this report focuses on the enablement of such analysis from the production cost modeling perspective. In particular, we contribute a bottom-up methodology for modeling load-shifting DR in production cost models. The resulting model is sufficiently detailed to reflect the physical characteristics and constraints of the underlying flexible load, and includes the possibility of capturing diurnal and seasonal variations in the resource. Nonetheless, the model is of low complexity and thus suitable for inclusion in conventional unit commitment and market clearing algorithms. The ability to simulate DR as an operational resource on a power system over a year facilitates an assessment of its time-varying value to the power system.

  14. A model of oxygen uptake kinetics in response to exercise: including a means of calculating oxygen demand/deficit/debt.

    PubMed

    Stirling, J R; Zakynthinaki, M S; Saltin, B

    2005-09-01

    We present a new model of the underlying dynamics of the oxygen uptake VO2(v,t) kinetics for various exercise intensities. This model is in the form of a set of nonlinear coupled vector fields for the VO2(v,t) and v, the derivative of the exercise intensity with respect to time. We also present a new and novel means for calculating the oxygen demand, D(v,t), and hence also the oxygen deficit and debt, given the time series of the VO2(v,t). This enables us to give better predictions for these values especially for when exercising at or close to maximal exercise intensities. Our model also allows us to predict the oxygen uptake time series given the time series for the exercise intensity as well as to investigate the oxygen uptake response to nonlinear exercise intensities. Neither of these features is possible using the currently used three-phase model. We also present a review of both the underlying physiology and the three-phase model. This includes for the first time a complete set of the analytical solutions of the three-phase model for the oxygen deficit and debt. PMID:15998492

  15. Dynamic Controls for Energy Efficiency and Demand Response:Framework Concepts and a New Construction Study Case in New York

    SciTech Connect

    Kiliccote, Sila; Piette, Mary Ann; Watson, David S.; Hughes, Glenn

    2006-06-20

    Many of today's advanced building control systems are designed to improve granularity of control for energy efficiency. Examples include direct digital controls for building heating, ventilation, and cooling systems (HVAC), and dimmable ballasts for continuous dimming for daylighting applications. This paper discusses recent research on the use of new and existing controls in commercial buildings for integrated energy efficiency and demand response (DR). The paper discusses the use of DR controls strategies in commercial buildings and provides specific details on DR control strategy design concepts for a new building in New York. We present preliminary results from EnergyPlus simulations of the DR strategies at the New York Times Headquarters building currently under construction. The DR strategies at the Times building involve unique state of the art systems with dimmable ballasts, movable shades on the glass facade, and underfloor air HVAC. The simulation efforts at this building are novel, with an innovative building owner considering DR and future DR program participation strategies during the design phase. This paper also discusses commissioning plans for the DR strategies. The trends in integration of various systems through the EMCS, master versus supervisory controls and dynamic operational modes concepts are presented and future research directions are outlined.

  16. Individual differences in oscillatory brain activity in response to varying attentional demands during a word recall and oculomotor dual task

    PubMed Central

    Kwon, Gusang; Lim, Sanghyun; Kim, Min-Young; Kwon, Hyukchan; Lee, Yong-Ho; Kim, Kiwoong; Lee, Eun-Ju; Suh, Minah

    2015-01-01

    Every day, we face situations that involve multi-tasking. How our brain utilizes cortical resources during multi-tasking is one of many interesting research topics. In this study, we tested whether a dual-task can be differentiated in the neural and behavioral responses of healthy subjects with varying degree of working memory capacity (WMC). We combined word recall and oculomotor tasks because they incorporate common neural networks including the fronto-parietal (FP) network. Three different types of oculomotor tasks (eye fixation, Fix-EM; predictive and random smooth pursuit eye movement, P-SPEM and R-SPEM) were combined with two memory load levels (low-load: five words, high-load: 10 words) for a word recall task. Each of those dual-task combinations was supposed to create varying cognitive loads on the FP network. We hypothesize that each dual-task requires different cognitive strategies for allocating the brain’s limited cortical resources and affects brain oscillation of the FP network. In addition, we hypothesized that groups with different WMC will show differential neural and behavioral responses. We measured oscillatory brain activity with simultaneous MEG and EEG recordings and behavioral performance by word recall. Prominent frontal midline (FM) theta (4–6 Hz) synchronization emerged in the EEG of the high-WMC group experiencing R-SPEM with high-load conditions during the early phase of the word maintenance period. Conversely, significant parietal upper alpha (10–12 Hz) desynchronization was observed in the EEG and MEG of the low-WMC group experiencing P-SPEM under high-load conditions during the same period. Different brain oscillatory patterns seem to depend on each individual’s WMC and varying attentional demands from different dual-task combinations. These findings suggest that specific brain oscillations may reflect different strategies for allocating cortical resources during combined word recall and oculomotor dual-tasks. PMID:26175681

  17. Metabolomics reveals differences in postprandial responses to breads and fasting metabolic characteristics associated with postprandial insulin demand in postmenopausal women.

    PubMed

    Moazzami, Ali A; Shrestha, Aahana; Morrison, David A; Poutanen, Kaisa; Mykkänen, Hannu

    2014-06-01

    Changes in serum metabolic profile after the intake of different food products (e.g., bread) can provide insight into their interaction with human metabolism. Postprandial metabolic responses were compared after the intake of refined wheat (RWB), whole-meal rye (WRB), and refined rye (RRB) breads. In addition, associations between the metabolic profile in fasting serum and the postprandial concentration of insulin in response to different breads were investigated. Nineteen postmenopausal women with normal fasting glucose and normal glucose tolerance participated in a randomized, controlled, crossover meal study. The test breads, RWB (control), RRB, and WRB, providing 50 g of available carbohydrate, were each served as a single meal. The postprandial metabolic profile was measured using nuclear magnetic resonance and targeted LC-mass spectrometry and was compared between different breads using ANOVA and multivariate models. Eight amino acids had a significant treatment effect (P < 0.01) and a significant treatment × time effect (P < 0.05). RWB produced higher postprandial concentrations of leucine (geometric mean: 224; 95% CI: 196, 257) and isoleucine (mean ± SD: 111 ± 31.5) compared with RRB (geometric mean: 165; 95% CI: 147, 186; mean ± SD: 84.2 ± 22.9) and WRB (geometric mean: 190; 95% CI: 174, 207; mean ± SD: 95.8 ± 17.3) at 60 min respectively (P < 0.001). In addition, 2 metabolic subgroups were identified using multivariate models based on the association between fasting metabolic profile and the postprandial concentration of insulin. Women with higher fasting concentrations of leucine and isoleucine and lower fasting concentrations of sphingomyelins and phosphatidylcholines had higher insulin responses despite similar glucose concentration after all kinds of bread (cross-validated ANOVA, P = 0.048). High blood concentration of branched-chain amino acids, i.e., leucine and isoleucine, has been associated with the increased risk of diabetes, which

  18. Teaching Personal and Social Responsibility and Transfer of Learning: Opportunities and Challenges for Teachers and Coaches

    ERIC Educational Resources Information Center

    Gordon, Barrie; Doyle, Stephanie

    2015-01-01

    The transfer of learning from the gym to other areas of participants' lives has always been a core component of the Teaching Personal and Social Responsibility Model. The degree to which transfer of learning is successfully facilitated in the reality of Teaching Personal and Social Responsibility Model-based teaching and coaching is, however,…

  19. Long-term power generation expansion planning with short-term demand response: Model, algorithms, implementation, and electricity policies

    NASA Astrophysics Data System (ADS)

    Lohmann, Timo

    Electric sector models are powerful tools that guide policy makers and stakeholders. Long-term power generation expansion planning models are a prominent example and determine a capacity expansion for an existing power system over a long planning horizon. With the changes in the power industry away from monopolies and regulation, the focus of these models has shifted to competing electric companies maximizing their profit in a deregulated electricity market. In recent years, consumers have started to participate in demand response programs, actively influencing electricity load and price in the power system. We introduce a model that features investment and retirement decisions over a long planning horizon of more than 20 years, as well as an hourly representation of day-ahead electricity markets in which sellers of electricity face buyers. This combination makes our model both unique and challenging to solve. Decomposition algorithms, and especially Benders decomposition, can exploit the model structure. We present a novel method that can be seen as an alternative to generalized Benders decomposition and relies on dynamic linear overestimation. We prove its finite convergence and present computational results, demonstrating its superiority over traditional approaches. In certain special cases of our model, all necessary solution values in the decomposition algorithms can be directly calculated and solving mathematical programming problems becomes entirely obsolete. This leads to highly efficient algorithms that drastically outperform their programming problem-based counterparts. Furthermore, we discuss the implementation of all tailored algorithms and the challenges from a modeling software developer's standpoint, providing an insider's look into the modeling language GAMS. Finally, we apply our model to the Texas power system and design two electricity policies motivated by the U.S. Environment Protection Agency's recently proposed CO2 emissions targets for the

  20. Demand response-enabled model predictive HVAC load control in buildings using real-time electricity pricing

    NASA Astrophysics Data System (ADS)

    Avci, Mesut

    A practical cost and energy efficient model predictive control (MPC) strategy is proposed for HVAC load control under dynamic real-time electricity pricing. The MPC strategy is built based on a proposed model that jointly minimizes the total energy consumption and hence, cost of electricity for the user, and the deviation of the inside temperature from the consumer's preference. An algorithm that assigns temperature set-points (reference temperatures) to price ranges based on the consumer's discomfort tolerance index is developed. A practical parameter prediction model is also designed for mapping between the HVAC load and the inside temperature. The prediction model and the produced temperature set-points are integrated as inputs into the MPC controller, which is then used to generate signal actions for the AC unit. To investigate and demonstrate the effectiveness of the proposed approach, a simulation based experimental analysis is presented using real-life pricing data. An actual prototype for the proposed HVAC load control strategy is then built and a series of prototype experiments are conducted similar to the simulation studies. The experiments reveal that the MPC strategy can lead to significant reductions in overall energy consumption and cost savings for the consumer. Results suggest that by providing an efficient response strategy for the consumers, the proposed MPC strategy can enable the utility providers to adopt efficient demand management policies using real-time pricing. Finally, a cost-benefit analysis is performed to display the economic feasibility of implementing such a controller as part of a building energy management system, and the payback period is identified considering cost of prototype build and cost savings to help the adoption of this controller in the building HVAC control industry.

  1. Influence of game format and number of players on heart rate responses and physical demands in small-sided soccer games.

    PubMed

    Castellano, Julen; Casamichana, David; Dellal, Alexandre

    2013-05-01

    The aim of the study was to examine the extent to which changing the game format (possession play vs. regulation goals and goalkeepers vs. small goals only) and the number of players (3 vs. 3, 5 vs. 5 and 7 vs. 7) influenced the physiological and physical demands of small-sided games (SSGs) in soccer in semiprofessional players. Fourteen semiprofessional male soccer players were monitored with global positioning system and heart rate devices. Heart rate, player load, distance covered, running speed, and the number of accelerations were recorded for 9 different SSGs. The results show that changes both in game format and the number of players affect the players' physiological and physical demands. Possession play places greater physiological and physical demands on players, although reducing the number of players only increases the physiological load. In the 7 vs. 7 games, changing the game format did not alter the heart rate responses. Finally, in the possession play format, changing the number of players did not produce significant differences in heart rate responses, although physical demands did decrease in line with a reduction in the number of players. These results should help coaches to understand how modifying different aspects of SSGs has a differential effect on the players' physiological and physical demands. Moreover, coaches in semiprofessional and amateur teams have now consistent information to design and optimize their training time in mixing the technical, tactical, and physical aspects.

  2. From Opportunity to Responsibility: Political Master Narratives, Social Policy, and Success Stories in Adult Literacy Education

    ERIC Educational Resources Information Center

    Sandlin, Jennifer A.; Clark, M. Carolyn

    2009-01-01

    Background and Context: The context for this study is the American legislative landscape covering the past 35 years, which witnessed a shift in political philosophies concerning the role of government in ensuring the social welfare of its citizens--from a focus on a "safety net" to a focus on "individual responsibility." We frame these contrasting…

  3. Impact of Technology on Human Rights: Responsibilities and Opportunities for the Social Studies.

    ERIC Educational Resources Information Center

    Higbee, Jay A.

    The author purports the need to control technology for the well-being of mankind by understanding and cultivating its beneficial features and countering its harmful effects and misuse. The intent of the paper is to alert social studies teachers to the responsibility of bridging the gap between scientific and technological knowledge and civic and…

  4. Processing Demands Impact 3-Year-Olds’ Performance in a Spontaneous-Response Task: New Evidence for the Processing-Load Account of Early False-Belief Understanding

    PubMed Central

    Scott, Rose M.; Roby, Erin

    2015-01-01

    Prior to age four, children succeed in non-elicited-response false-belief tasks but fail elicited-response false-belief tasks. To explain this discrepancy, the processing-load account argues that the capacity to represent beliefs emerges in infancy, as indicated by early success on non-elicited-response tasks, but that children’s ability to demonstrate this capacity depends on the processing demands of the task and children’s processing skills. When processing demands exceed young children’s processing abilities, such as in standard elicited-response tasks, children fail despite their capacity to represent beliefs. Support for this account comes from recent evidence that reducing processing demands improves young children’s performance: when demands are sufficiently reduced, 2.5-year-olds succeed in elicited-response tasks. Here we sought complementary evidence for the processing-load account by examining whether increasing processing demands impeded children’s performance in a non-elicited-response task. 3-year-olds were tested in a preferential-looking task in which they heard a change-of-location false-belief story accompanied by a picture book; across children, we manipulated the amount of linguistic ambiguity in the story. The final page of the book showed two images: one that was consistent with the main character’s false belief and one that was consistent with reality. When the story was relatively unambiguous, children looked reliably longer at the false-belief-consistent image, successfully demonstrating their false-belief understanding. When the story was ambiguous, however, this undermined children’s performance: looking times to the belief-consistent image were correlated with verbal ability, and only children with verbal skills in the upper quartile of the sample demonstrated a significant preference for the belief-consistent image. These results support the processing-load account by demonstrating that regardless of whether a task

  5. Processing Demands Impact 3-Year-Olds' Performance in a Spontaneous-Response Task: New Evidence for the Processing-Load Account of Early False-Belief Understanding.

    PubMed

    Scott, Rose M; Roby, Erin

    2015-01-01

    Prior to age four, children succeed in non-elicited-response false-belief tasks but fail elicited-response false-belief tasks. To explain this discrepancy, the processing-load account argues that the capacity to represent beliefs emerges in infancy, as indicated by early success on non-elicited-response tasks, but that children's ability to demonstrate this capacity depends on the processing demands of the task and children's processing skills. When processing demands exceed young children's processing abilities, such as in standard elicited-response tasks, children fail despite their capacity to represent beliefs. Support for this account comes from recent evidence that reducing processing demands improves young children's performance: when demands are sufficiently reduced, 2.5-year-olds succeed in elicited-response tasks. Here we sought complementary evidence for the processing-load account by examining whether increasing processing demands impeded children's performance in a non-elicited-response task. 3-year-olds were tested in a preferential-looking task in which they heard a change-of-location false-belief story accompanied by a picture book; across children, we manipulated the amount of linguistic ambiguity in the story. The final page of the book showed two images: one that was consistent with the main character's false belief and one that was consistent with reality. When the story was relatively unambiguous, children looked reliably longer at the false-belief-consistent image, successfully demonstrating their false-belief understanding. When the story was ambiguous, however, this undermined children's performance: looking times to the belief-consistent image were correlated with verbal ability, and only children with verbal skills in the upper quartile of the sample demonstrated a significant preference for the belief-consistent image. These results support the processing-load account by demonstrating that regardless of whether a task involves an elicited

  6. Processing Demands Impact 3-Year-Olds' Performance in a Spontaneous-Response Task: New Evidence for the Processing-Load Account of Early False-Belief Understanding.

    PubMed

    Scott, Rose M; Roby, Erin

    2015-01-01

    Prior to age four, children succeed in non-elicited-response false-belief tasks but fail elicited-response false-belief tasks. To explain this discrepancy, the processing-load account argues that the capacity to represent beliefs emerges in infancy, as indicated by early success on non-elicited-response tasks, but that children's ability to demonstrate this capacity depends on the processing demands of the task and children's processing skills. When processing demands exceed young children's processing abilities, such as in standard elicited-response tasks, children fail despite their capacity to represent beliefs. Support for this account comes from recent evidence that reducing processing demands improves young children's performance: when demands are sufficiently reduced, 2.5-year-olds succeed in elicited-response tasks. Here we sought complementary evidence for the processing-load account by examining whether increasing processing demands impeded children's performance in a non-elicited-response task. 3-year-olds were tested in a preferential-looking task in which they heard a change-of-location false-belief story accompanied by a picture book; across children, we manipulated the amount of linguistic ambiguity in the story. The final page of the book showed two images: one that was consistent with the main character's false belief and one that was consistent with reality. When the story was relatively unambiguous, children looked reliably longer at the false-belief-consistent image, successfully demonstrating their false-belief understanding. When the story was ambiguous, however, this undermined children's performance: looking times to the belief-consistent image were correlated with verbal ability, and only children with verbal skills in the upper quartile of the sample demonstrated a significant preference for the belief-consistent image. These results support the processing-load account by demonstrating that regardless of whether a task involves an elicited

  7. Estimating Demand Response Load Impacts: Evaluation of BaselineLoad Models for Non-Residential Buildings in California

    SciTech Connect

    Coughlin, Katie; Piette, Mary Ann; Goldman, Charles; Kiliccote,Sila

    2008-01-01

    Both Federal and California state policymakers areincreasingly interested in developing more standardized and consistentapproaches to estimate and verify the load impacts of demand responseprograms and dynamic pricing tariffs. This study describes a statisticalanalysis of the performance of different models used to calculate thebaseline electric load for commercial buildings participating in ademand-response (DR) program, with emphasis onthe importance of weathereffects. During a DR event, a variety of adjustments may be made tobuilding operation, with the goal of reducing the building peak electricload. In order to determine the actual peak load reduction, an estimateof what the load would have been on the day of the event without any DRactions is needed. This baseline load profile (BLP) is key to accuratelyassessing the load impacts from event-based DR programs and may alsoimpact payment settlements for certain types of DR programs. We testedseven baseline models on a sample of 33 buildings located in California.These models can be loosely categorized into two groups: (1) averagingmethods, which use some linear combination of hourly load values fromprevious days to predict the load on the event, and (2) explicit weathermodels, which use a formula based on local hourly temperature to predictthe load. The models were tested both with and without morningadjustments, which use data from the day of the event to adjust theestimated BLP up or down.Key findings from this study are: - The accuracyof the BLP model currently used by California utilities to estimate loadreductions in several DR programs (i.e., hourly usage in highest 3 out of10 previous days) could be improved substantially if a morning adjustmentfactor were applied for weather-sensitive commercial and institutionalbuildings. - Applying a morning adjustment factor significantly reducesthe bias and improves the accuracy of all BLP models examined in oursample of buildings. - For buildings with low load

  8. Cumulative gains enhance striatal response to reward opportunities in alcohol-dependent patients

    PubMed Central

    Gilman, Jodi M.; Smith, Ashley R.; Bjork, James M.; Ramchandani, Vijay A.; Momenan, Reza; Hommer, Daniel W.

    2016-01-01

    Substance use disorder is characterized by a transition from volitional to compulsive responding for drug reward. A possible explanation for this transition may be that alcohol-dependent patients (ADP) show a general propensity for a history of rewarded instrumental responses, and these rewarded responses may boost the activation of motivational neurocircuitry for additional reward. Brain imaging studies of decision-making have demonstrated that ADP relative to controls (CON) often show altered neural activation in response to anticipating and receiving rewards, but the majority of studies have not investigated how past performance affects activation. A potential exists for ADP to show increased sensitivity to reward as a function of reward delivery history. In the current study, we used functional magnetic resonance imaging to investigate the neural correlates of risky decision-making in ADP (n = 18) and CON (n = 18) while they played a two-choice monetary risk-taking game. In addition to investigating general neural recruitment by risky decision-making, we also modeled each participant’s running total of monetary earnings in order to determine areas of activation that correlated with cumulative reward. We found that ADP and CON showed few differences in behavior or in mesolimbic activation by choice for, and receipt of, risky gains. However, when including a cumulative-earnings covariate, ADP exhibited heightened striatal activation that correlated with total earnings during the choice event in the task. The heightened contextual sensitivity of striatal responses to cumulative earnings in ADP may represent a general neurobiological affective substrate for development of automatized instrumental behavior. PMID:24754451

  9. Food, water, and fault lines: Remote sensing opportunities for earthquake-response management of agricultural water.

    PubMed

    Rodriguez, Jenna; Ustin, Susan; Sandoval-Solis, Samuel; O'Geen, Anthony Toby

    2016-09-15

    Earthquakes often cause destructive and unpredictable changes that can affect local hydrology (e.g. groundwater elevation or reduction) and thus disrupt land uses and human activities. Prolific agricultural regions overlie seismically active areas, emphasizing the importance to improve our understanding and monitoring of hydrologic and agricultural systems following a seismic event. A thorough data collection is necessary for adequate post-earthquake crop management response; however, the large spatial extent of earthquake's impact makes challenging the collection of robust data sets for identifying locations and magnitude of these impacts. Observing hydrologic responses to earthquakes is not a novel concept, yet there is a lack of methods and tools for assessing earthquake's impacts upon the regional hydrology and agricultural systems. The objective of this paper is to describe how remote sensing imagery, methods and tools allow detecting crop responses and damage incurred after earthquakes because a change in the regional hydrology. Many remote sensing datasets are long archived with extensive coverage and with well-documented methods to assess plant-water relations. We thus connect remote sensing of plant water relations to its utility in agriculture using a post-earthquake agrohydrologic remote sensing (PEARS) framework; specifically in agro-hydrologic relationships associated with recent earthquake events that will lead to improved water management.

  10. Tropical forest responses to increasing [CO2]: current knowledge and opportunities for future research

    SciTech Connect

    Cernusak, Lucas; Winter, Klaus; Dalling, James; Holtum, Joseph; Jaramillo, Carlos; Korner, Christian; Leakey, Andrew D.B.; Norby, Richard J; Poulter, Benjamin; Turner, Benjamin; Wright, S. Joseph

    2013-01-01

    Elevated atmospheric [CO2] (ca) will undoubtedly affect the metabolism of tropical forests worldwide; however, critical aspects of how tropical forests will respond remain largely unknown. Here we review the current state of knowledge about physiological and ecological responses, with the aim of providing a framework that can help to guide future experimental research. Modelling studies have indicated that elevated ca can potentially stimulate photosynthesis more in the tropics than at higher latitudes, because suppression of photorespiration by elevated ca increases with temperature. However, canopy leaves in tropical forests could also potentially reach a high temperature threshold under elevated ca that will moderate the rise in photosynthesis. Belowground responses, including fine root production, nutrient foraging, and soil organic matter processing, will be especially important to the integrated ecosystem response to elevated CO2. Water-use efficiency will increase as ca rises, potentially impacting upon soil moisture status and nutrient availability. Recruitment may be differentially altered for some functional groups, potentially decreasing ecosystem carbon storage. Whole-forest CO2 enrichment experiments are urgently needed to test predictions of tropical forest functioning under elevated ca. Smaller scale experiments in the understory and in gaps would also be informative, and could provide stepping stones toward stand-scale manipulations.

  11. Food, water, and fault lines: Remote sensing opportunities for earthquake-response management of agricultural water.

    PubMed

    Rodriguez, Jenna; Ustin, Susan; Sandoval-Solis, Samuel; O'Geen, Anthony Toby

    2016-09-15

    Earthquakes often cause destructive and unpredictable changes that can affect local hydrology (e.g. groundwater elevation or reduction) and thus disrupt land uses and human activities. Prolific agricultural regions overlie seismically active areas, emphasizing the importance to improve our understanding and monitoring of hydrologic and agricultural systems following a seismic event. A thorough data collection is necessary for adequate post-earthquake crop management response; however, the large spatial extent of earthquake's impact makes challenging the collection of robust data sets for identifying locations and magnitude of these impacts. Observing hydrologic responses to earthquakes is not a novel concept, yet there is a lack of methods and tools for assessing earthquake's impacts upon the regional hydrology and agricultural systems. The objective of this paper is to describe how remote sensing imagery, methods and tools allow detecting crop responses and damage incurred after earthquakes because a change in the regional hydrology. Many remote sensing datasets are long archived with extensive coverage and with well-documented methods to assess plant-water relations. We thus connect remote sensing of plant water relations to its utility in agriculture using a post-earthquake agrohydrologic remote sensing (PEARS) framework; specifically in agro-hydrologic relationships associated with recent earthquake events that will lead to improved water management. PMID:27241204

  12. Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.

    PubMed

    Buckner, Jane H; Nepom, Gerald T

    2016-07-01

    Autoreactive lymphocytes display a programmed set of characteristic effector functions and phenotypic markers that, in combination with antigen-specific profiling, provide a detailed picture of the adaptive immune response in Type 1 diabetes (T1D). The CD4+ T cell effector compartment (referred to as "Teff" in this article) has been extensively analyzed, particularly because the HLA genes most strongly associated with T1D are MHC class II alleles that form restriction elements for CD4+ T cell recognition. This "guilt by association" can now be revisited in terms of specific immune mechanisms and specific forms of T cell recognition that are displayed by Teff found in subjects with T1D. In this review, we describe properties of Teff that correlate with T1D, and discuss several characteristics that advance our understanding of disease persistence and progression. Focusing on functional disease-associated immunological pathways within these Teff suggests a rationale for next-generation clinical trials with targeted interventions. Indeed, immune modulation therapies in T1D that do not address these properties of Teff are unlikely to achieve durable clinical response.

  13. Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.

    PubMed

    Buckner, Jane H; Nepom, Gerald T

    2016-07-01

    Autoreactive lymphocytes display a programmed set of characteristic effector functions and phenotypic markers that, in combination with antigen-specific profiling, provide a detailed picture of the adaptive immune response in Type 1 diabetes (T1D). The CD4+ T cell effector compartment (referred to as "Teff" in this article) has been extensively analyzed, particularly because the HLA genes most strongly associated with T1D are MHC class II alleles that form restriction elements for CD4+ T cell recognition. This "guilt by association" can now be revisited in terms of specific immune mechanisms and specific forms of T cell recognition that are displayed by Teff found in subjects with T1D. In this review, we describe properties of Teff that correlate with T1D, and discuss several characteristics that advance our understanding of disease persistence and progression. Focusing on functional disease-associated immunological pathways within these Teff suggests a rationale for next-generation clinical trials with targeted interventions. Indeed, immune modulation therapies in T1D that do not address these properties of Teff are unlikely to achieve durable clinical response. PMID:26948997

  14. Genome-Wide Transcriptional Profile Analysis of Prunus persica in Response to Low Sink Demand after Fruit Removal.

    PubMed

    Duan, Wei; Xu, Hongguo; Liu, Guotian; Fan, Peige; Liang, Zhenchang; Li, Shaohua

    2016-01-01

    Prunus persica fruits were removed from 1-year-old shoots to analysis photosynthesis, chlorophyll fluorescence and genes changes in leaves to low sink demand caused by fruit removal (-fruit) during the final stage of rapid fruit growth. A decline in net photosynthesis rate was observed, accompanied with a decrease in stomatal conductance. The intercellular CO2 concentrations and leaf temperature increased as compared with a normal fruit load (+fruit). Moreover, low sink demand significantly inhibited the donor side and the reaction center of photosystem II. 382 genes in leaf with an absolute fold change ≥1 change in expression level, representing 116 up- and 266 down-regulated genes except for unknown transcripts. Among these, 25 genes for photosynthesis were down-regulated, 69 stress and 19 redox related genes up-regulated under the low sink demand. These studies revealed high leaf temperature may result in a decline of net photosynthesis rate through down-regulation in photosynthetic related genes and up-regulation in redox and stress related genes, especially heat shock proteins genes. The complex changes in genes at the transcriptional level under low sink demand provided useful starting points for in-depth analyses of source-sink relationship in P. persica. PMID:27446115

  15. Genome-Wide Transcriptional Profile Analysis of Prunus persica in Response to Low Sink Demand after Fruit Removal

    PubMed Central

    Duan, Wei; Xu, Hongguo; Liu, Guotian; Fan, Peige; Liang, Zhenchang; Li, Shaohua

    2016-01-01

    Prunus persica fruits were removed from 1-year-old shoots to analysis photosynthesis, chlorophyll fluorescence and genes changes in leaves to low sink demand caused by fruit removal (−fruit) during the final stage of rapid fruit growth. A decline in net photosynthesis rate was observed, accompanied with a decrease in stomatal conductance. The intercellular CO2 concentrations and leaf temperature increased as compared with a normal fruit load (+fruit). Moreover, low sink demand significantly inhibited the donor side and the reaction center of photosystem II. 382 genes in leaf with an absolute fold change ≥1 change in expression level, representing 116 up- and 266 down-regulated genes except for unknown transcripts. Among these, 25 genes for photosynthesis were down-regulated, 69 stress and 19 redox related genes up-regulated under the low sink demand. These studies revealed high leaf temperature may result in a decline of net photosynthesis rate through down-regulation in photosynthetic related genes and up-regulation in redox and stress related genes, especially heat shock proteins genes. The complex changes in genes at the transcriptional level under low sink demand provided useful starting points for in-depth analyses of source-sink relationship in P. persica. PMID:27446115

  16. On-Demand Testing and Maintaining Standards for General Qualifications in the UK Using Item Response Theory: Possibilities and Challenges

    ERIC Educational Resources Information Center

    He, Qingping

    2012-01-01

    Background: Although on-demand testing is being increasingly used in many areas of assessment, it has not been adopted in high stakes examinations like the General Certificate of Secondary Education (GCSE) and General Certificate of Education Advanced level (GCE A level) offered by awarding organisations (AOs) in the UK. One of the major issues…

  17. Genome-Wide Transcriptional Profile Analysis of Prunus persica in Response to Low Sink Demand after Fruit Removal.

    PubMed

    Duan, Wei; Xu, Hongguo; Liu, Guotian; Fan, Peige; Liang, Zhenchang; Li, Shaohua

    2016-01-01

    Prunus persica fruits were removed from 1-year-old shoots to analysis photosynthesis, chlorophyll fluorescence and genes changes in leaves to low sink demand caused by fruit removal (-fruit) during the final stage of rapid fruit growth. A decline in net photosynthesis rate was observed, accompanied with a decrease in stomatal conductance. The intercellular CO2 concentrations and leaf temperature increased as compared with a normal fruit load (+fruit). Moreover, low sink demand significantly inhibited the donor side and the reaction center of photosystem II. 382 genes in leaf with an absolute fold change ≥1 change in expression level, representing 116 up- and 266 down-regulated genes except for unknown transcripts. Among these, 25 genes for photosynthesis were down-regulated, 69 stress and 19 redox related genes up-regulated under the low sink demand. These studies revealed high leaf temperature may result in a decline of net photosynthesis rate through down-regulation in photosynthetic related genes and up-regulation in redox and stress related genes, especially heat shock proteins genes. The complex changes in genes at the transcriptional level under low sink demand provided useful starting points for in-depth analyses of source-sink relationship in P. persica.

  18. Genetic influences of angiotensin-converting enzyme inhibitor response: an opportunity for personalizing therapy?

    PubMed

    Brugts, Jasper J; Simoons, Maarten L

    2012-08-01

    The angiotensin-converting enzyme (ACE) inhibitors are a cornerstone drug therapy in the current treatment of patients with hypertension, stable coronary artery disease and heart failure. Individualizing therapy of ACE inhibitors with clinical risk factors in low-risk patients with stable coronary artery disease is not feasible. The concept of pharmacogenetics, by studying patient factors more individually, offers a first glimpse in the quest for the 'holy grail' of personalized medicine. As such, genetic targets in the direct pharmacodynamic pathway of ACE inhibitors, the renin-angiotensin-aldosterone system, is a plausible candidate for such an approach. In the past few decades, results of pharmacogenetic studies were scarce and inconsistent. However, recently the first reports of larger pharmacogenetic studies are now confirming that the 'pharmacogenetic approach' might be feasible in the future. The current review focuses on the recent developments in pharmacogenetic research in response to ACE inhibitors in patients with stable coronary artery disease. PMID:23030290

  19. Insula Demonstrates a Non-Linear Response to Varying Demand for Cognitive Control and Weaker Resting Connectivity With the Executive Control Network in Smokers.

    PubMed

    Fedota, John R; Matous, Allison L; Salmeron, Betty Jo; Gu, Hong; Ross, Thomas J; Stein, Elliot A

    2016-09-01

    Deficits in cognitive control processes are a primary characteristic of nicotine addiction. However, while network-based connectivity measures of dysfunction have frequently been observed, empirical evidence of task-based dysfunction in these processes has been inconsistent. Here, in a sample of smokers (n=35) and non-smokers (n=21), a previously validated parametric flanker task is employed to characterize addiction-related alterations in responses to varying (ie, high, intermediate, and low) demands for cognitive control. This approach yields a demand-response curve that aims to characterize potential non-linear responses to increased demand for control, including insensitivities or lags in fully activating the cognitive control network. We further used task-based differences in activation between groups as seeds for resting-state analysis of network dysfunction in an effort to more closely link prior inconsistencies in task-related activation with evidence of impaired network connectivity in smokers. For both smokers and non-smokers, neuroimaging results showed similar increases in activation in brain areas associated with cognitive control. However, reduced activation in right insula was seen only in smokers and only when processing intermediate demand for cognitive control. Further, in smokers, this task-modulated right insula showed weaker functional connectivity with the superior frontal gyrus, a component of the task-positive executive control network. These results demonstrate that the neural instantiation of salience attribution in smokers is both more effortful to fully activate and has more difficulty communicating with the exogenous, task-positive, executive control network. Together, these findings further articulate the cognitive control dysfunction associated with smoking and illustrate a specific brain circuit potentially responsible.

  20. A Test Bed for Self-regulating Distribution Systems: Modeling Intergrated Renewable Energy and Demand Response in the GridLAB-D/MATLAB Environment

    SciTech Connect

    Wang, Dan; de Wit, Braydon; Parkinson, Simon; Fuller, Jason C.; Chassin, David P.; Crawford, Curran; Djilali, Ned

    2012-01-16

    This paper discusses the development of a simulation test bed permitting the study of integrated renewable energy generators and controlled distributed heat pumps operating within distribution systems. The test bed is demonstrated in this paper by addressing the important issue of the self-regulating effect of consumer-owned air-source heat pumps on the variability induced by wind power integration, particularly when coupled with increased access to demand response realized through a centralized load control strategy.

  1. Identifying predictive features in drug response using machine learning: opportunities and challenges.

    PubMed

    Vidyasagar, Mathukumalli

    2015-01-01

    This article reviews several techniques from machine learning that can be used to study the problem of identifying a small number of features, from among tens of thousands of measured features, that can accurately predict a drug response. Prediction problems are divided into two categories: sparse classification and sparse regression. In classification, the clinical parameter to be predicted is binary, whereas in regression, the parameter is a real number. Well-known methods for both classes of problems are briefly discussed. These include the SVM (support vector machine) for classification and various algorithms such as ridge regression, LASSO (least absolute shrinkage and selection operator), and EN (elastic net) for regression. In addition, several well-established methods that do not directly fall into machine learning theory are also reviewed, including neural networks, PAM (pattern analysis for microarrays), SAM (significance analysis for microarrays), GSEA (gene set enrichment analysis), and k-means clustering. Several references indicative of the application of these methods to cancer biology are discussed.

  2. Forests of opportunities and mischief: disentangling the interactions between forests, parasites and immune responses.

    PubMed

    Renner, Swen C; Lüdtke, Bruntje; Kaiser, Sonja; Kienle, Julia; Schaefer, H Martin; Segelbacher, Gernot; Tschapka, Marco; Santiago-Alarcon, Diego

    2016-08-01

    Habitat characteristics determine the presence of individuals through resource availability, but at the same time, such features also influence the occurrence of parasites. We analyzed how birds respond to changes in interior forest structures, to forest management regimes, and to the risk of haemosporidian infections. We captured and took blood samples from blackcaps (Sylvia atricapilla) and chaffinches (Fringilla coelebs) in three different forest types (beech, mixed deciduous, spruce). We measured birds' body asymmetries, detected avian haemosporidians, and counted white blood cells as an immune measure of each individual per forest type. We used, to our knowledge for the first time, continuous forest structural parameters to quantify habitat structure, and found significant effects of habitat structure on parasite prevalence that previously have been undetected. We found three times higher prevalence for blackcaps compared with chaffinches. Parasite intensity varied significantly within host species depending on forest type, being lowest in beech forests for both host species. Structurally complex habitats with a high degree of entropy had a positive effect on the likelihood of acquiring an infection, but the effect on prevalence was negative for forest sections with a south facing aspect. For blackcaps, forest gaps also had a positive effect on prevalence, but canopy height had a negative one. Our results suggest that forest types and variations in forest structure influence the likelihood of acquiring an infection, which subsequently has an influence on host health status and body condition; however, responses to some environmental factors are host-specific. PMID:27247106

  3. Forests of opportunities and mischief: disentangling the interactions between forests, parasites and immune responses.

    PubMed

    Renner, Swen C; Lüdtke, Bruntje; Kaiser, Sonja; Kienle, Julia; Schaefer, H Martin; Segelbacher, Gernot; Tschapka, Marco; Santiago-Alarcon, Diego

    2016-08-01

    Habitat characteristics determine the presence of individuals through resource availability, but at the same time, such features also influence the occurrence of parasites. We analyzed how birds respond to changes in interior forest structures, to forest management regimes, and to the risk of haemosporidian infections. We captured and took blood samples from blackcaps (Sylvia atricapilla) and chaffinches (Fringilla coelebs) in three different forest types (beech, mixed deciduous, spruce). We measured birds' body asymmetries, detected avian haemosporidians, and counted white blood cells as an immune measure of each individual per forest type. We used, to our knowledge for the first time, continuous forest structural parameters to quantify habitat structure, and found significant effects of habitat structure on parasite prevalence that previously have been undetected. We found three times higher prevalence for blackcaps compared with chaffinches. Parasite intensity varied significantly within host species depending on forest type, being lowest in beech forests for both host species. Structurally complex habitats with a high degree of entropy had a positive effect on the likelihood of acquiring an infection, but the effect on prevalence was negative for forest sections with a south facing aspect. For blackcaps, forest gaps also had a positive effect on prevalence, but canopy height had a negative one. Our results suggest that forest types and variations in forest structure influence the likelihood of acquiring an infection, which subsequently has an influence on host health status and body condition; however, responses to some environmental factors are host-specific.

  4. Involvement of immune response in the pathogenesis of amyotrophic lateral sclerosis: a therapeutic opportunity?

    PubMed

    Calvo, A; Moglia, C; Balma, M; Chiò, A

    2010-07-01

    The immune system has been found to be involved with positive and negative effects in the nervous system of amyotrophic lateral sclerosis (ALS) patients. In general, T cells, B cells, NK cells, mast cells, macrophages, dendritic cells, microglia, antibodies, complement and cytokines participate in limiting damage. Several mechanisms of action, such as production of neurotrophic growth factors and interaction with neurons and glial cells, have been shown to preserve these latter from injury and stimulate growth and repair. The immune system also participates in proliferation of neural progenitor stem cells and their migration to sites of injury and this activity has been documented in various neurologic disorders including traumatic injury, ischemic and hemorrhagic stroke, multiple sclerosis, infection, and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and ALS). Many therapies have been shown to stimulate the protective and regenerative aspects of the immune system in humans, such as intravenous immunoglobulins, and other experimental interventions such as vaccination, minocycline, antibodies and neural stem cells, have shown promise in animal models of ALS. Consequently, several immunosuppressive and immunomodulatory therapies have been tried in ALS, generally with no success, in particular intravenous immunoglobulins. The multiple aspects of the immune response in ALS are beginning to be appreciated, and their potential as pharmacologic targets in neurologic disease is being explored. PMID:20406178

  5. An essential need: creating opportunities for veterinary students and graduates to gain an appreciation of responsibilities and opportunities in global veterinary issues.

    PubMed

    Malone, J B; Bavia, M E; Stromberg, B E; Valadao, C; Wiles, W T; Diaz, J H; Bergquist, R

    2009-08-01

    Globalisation trends and bioterrorism issues have led to new concerns relating to public health, animal health, international trade and food security. There is an imperative to internationalise and strengthen global public health capacity by renewed emphasis on veterinary public health in veterinary education and increasing opportunities for elective experiential learning in public practice programmes for veterinary students. Recent experience with a US-Brazil Higher Education Consortia Program is used as an example of potential ways in which veterinary students can gain an appreciation for global veterinary issues.

  6. Using institutional theory to analyse hospital responses to external demands for finance and quality in five European countries

    PubMed Central

    Mendel, Peter; Nunes, Francisco; Wiig, Siri; van den Bovenkamp, Hester; Karltun, Anette; Robert, Glenn; Anderson, Janet; Vincent, Charles; Fulop, Naomi

    2015-01-01

    Objectives Given the impact of the global economic crisis, delivering better health care with limited finance grows more challenging. Through the lens of institutional theory, this paper explores pressures experienced by hospital leaders to improve quality and constrain spending, focusing on how they respond to these often competing demands. Methods An in-depth, multilevel analysis of health care quality policies and practices in five European countries including longitudinal case studies in a purposive sample of ten hospitals. Results How hospitals responded to the financial and quality challenges was dependent upon three factors: the coherence of demands from external institutions; managerial competence to align external demands with an overall quality improvement strategy, and managerial stability. Hospital leaders used diverse strategies and practices to manage conflicting external pressures. Conclusions The development of hospital leaders’ skills in translating external requirements into implementation plans with internal support is a complex, but crucial, task, if quality is to remain a priority during times of austerity. Increasing quality improvement skills within a hospital, developing a culture where quality improvement becomes embedded and linking cost reduction measures to improving care are all required. PMID:26683885

  7. Increased intra-individual reaction time variability in attention-deficit/hyperactivity disorder across response inhibition tasks with different cognitive demands.

    PubMed

    Vaurio, Rebecca G; Simmonds, Daniel J; Mostofsky, Stewart H

    2009-10-01

    One of the most consistent findings in children with ADHD is increased moment-to-moment variability in reaction time (RT). The source of increased RT variability can be examined using ex-Gaussian analyses that divide variability into normal and exponential components and Fast Fourier transform (FFT) that allow for detailed examination of the frequency of responses in the exponential distribution. Prior studies of ADHD using these methods have produced variable results, potentially related to differences in task demand. The present study sought to examine the profile of RT variability in ADHD using two Go/No-go tasks with differing levels of cognitive demand. A total of 140 children (57 with ADHD and 83 typically developing controls), ages 8-13 years, completed both a "simple" Go/No-go task and a more "complex" Go/No-go task with increased working memory load. Repeated measures ANOVA of ex-Gaussian functions revealed for both tasks children with ADHD demonstrated increased variability in both the normal/Gaussian (significantly elevated sigma) and the exponential (significantly elevated tau) components. In contrast, FFT analysis of the exponential component revealed a significant task x diagnosis interaction, such that infrequent slow responses in ADHD differed depending on task demand (i.e., for the simple task, increased power in the 0.027-0.074 Hz frequency band; for the complex task, decreased power in the 0.074-0.202 Hz band). The ex-Gaussian findings revealing increased variability in both the normal (sigma) and exponential (tau) components for the ADHD group, suggest that both impaired response preparation and infrequent "lapses in attention" contribute to increased variability in ADHD. FFT analyses reveal that the periodicity of intermittent lapses of attention in ADHD varies with task demand. The findings provide further support for intra-individual variability as a candidate intermediate endophenotype of ADHD. PMID:19552927

  8. Increased intra-individual reaction time variability in attention-deficit/hyperactivity disorder across response inhibition tasks with different cognitive demands

    PubMed Central

    Vaurio, Rebecca G.; Simmonds, Daniel J.; Mostofsky, Stewart H.

    2015-01-01

    One of the most consistent findings in children with ADHD is increased moment-to-moment variability in reaction time (RT). The source of increased RT variability can be examined using ex-Gaussian analyses that divide variability into normal and exponential components and Fast Fourier transform (FFT) that allow for detailed examination of the frequency of responses in the exponential distribution. Prior studies of ADHD using these methods have produced variable results, potentially related to differences in task demand. The present study sought to examine the profile of RT variability in ADHD using two Go/No-go tasks with differing levels of cognitive demand. A total of 140 children (57 with ADHD and 83 typically developing controls), ages 8–13 years, completed both a “simple” Go/No-go task and a more “complex” Go/No-go task with increased working memory load. Repeated measures ANOVA of ex-Gaussian functions revealed for both tasks children with ADHD demonstrated increased variability in both the normal/Gaussian (significantly elevated sigma) and the exponential (significantly elevated tau) components. In contrast, FFT analysis of the exponential component revealed a significant task × diagnosis interaction, such that infrequent slow responses in ADHD differed depending on task demand (i.e., for the simple task, increased power in the 0.027–0.074 Hz frequency band; for the complex task, decreased power in the 0.074–0.202 Hz band). The ex-Gaussian findings revealing increased variability in both the normal (sigma) and exponential (tau) components for the ADHD group, suggest that both impaired response preparation and infrequent “lapses in attention” contribute to increased variability in ADHD. FFT analyses reveal that the periodicity of intermittent lapses of attention in ADHD varies with task demand. The findings provide further support for intra-individual variability as a candidate intermediate endophenotype of ADHD. PMID:19552927

  9. Demanding Satisfaction

    ERIC Educational Resources Information Center

    Oguntoyinbo, Lekan

    2010-01-01

    It was the kind of crisis most universities dread. In November 2006, a group of minority student leaders at Indiana University-Purdue University Indianapolis (IUPUI) threatened to sue the university if administrators did not heed demands that included providing more funding for multicultural student groups. This article discusses how this threat…

  10. Evaluation of soil-foundation-structure interaction effects on seismic response demands of multi-story MRF buildings on raft foundations

    NASA Astrophysics Data System (ADS)

    Abdel Raheem, Shehata E.; Ahmed, Mohamed M.; Alazrak, Tarek M. A.

    2015-03-01

    Soil conditions have a great deal to do with damage to structures during earthquakes. Hence the investigation on the energy transfer mechanism from soils to buildings during earthquakes is critical for the seismic design of multi-story buildings and for upgrading existing structures. Thus, the need for research into soil-structure interaction (SSI) problems is greater than ever. Moreover, recent studies show that the effects of SSI may be detrimental to the seismic response of structure and neglecting SSI in analysis may lead to un-conservative design. Despite this, the conventional design procedure usually involves assumption of fixity at the base of foundation neglecting the flexibility of the foundation, the compressibility of the underneath soil and, consequently, the effect of foundation settlement on further redistribution of bending moment and shear force demands. Hence the SSI analysis of multi-story buildings is the main focus of this research; the effects of SSI are analyzed for typical multi-story building resting on raft foundation. Three methods of analysis are used for seismic demands evaluation of the target moment-resistant frame buildings: equivalent static load; response spectrum methods and nonlinear time history analysis with suit of nine time history records. Three-dimensional FE model is constructed to investigate the effects of different soil conditions and number of stories on the vibration characteristics and seismic response demands of building structures. Numerical results obtained using SSI model with different soil conditions are compared to those corresponding to fixed-base support modeling assumption. The peak responses of story shear, story moment, story displacement, story drift, moments at beam ends, as well as force of inner columns are analyzed. The results of different analysis approaches are used to evaluate the advantages, limitations, and ease of application of each approach for seismic analysis.

  11. Demand Side Bidding. Final Report

    SciTech Connect

    Spahn, Andrew

    2003-12-31

    This document sets forth the final report for a financial assistance award for the National Association of Regulatory Utility Commissioners (NARUC) to enhance coordination between the building operators and power system operators in terms of demand-side responses to Location Based Marginal Pricing (LBMP). Potential benefits of this project include improved power system reliability, enhanced environmental quality, mitigation of high locational prices within congested areas, and the reduction of market barriers for demand-side market participants. NARUC, led by its Committee on Energy Resources and the Environment (ERE), actively works to promote the development and use of energy efficiency and clean distributive energy policies within the framework of a dynamic regulatory environment. Electric industry restructuring, energy shortages in California, and energy market transformation intensifies the need for reliable information and strategies regarding electric reliability policy and practice. NARUC promotes clean distributive generation and increased energy efficiency in the context of the energy sector restructuring process. NARUC, through ERE's Subcommittee on Energy Efficiency, strives to improve energy efficiency by creating working markets. Market transformation seeks opportunities where small amounts of investment can create sustainable markets for more efficient products, services, and design practices.

  12. Responses to climate and economic risks and opportunities across national and ecological boundaries: changing household strategies on the Mongolian plateau

    PubMed Central

    Brown, Daniel G.; Agrawal, Arun; Sass, Daniel A.; Wang, Jun; Hua, Jin; Xie, Yichun

    2013-01-01

    Climate changes on the Mongolian Plateau are creating new challenges for the households and communities of the region. Much of the existing research on household choices in response to climate variability and change focuses on environmental risks and stresses. In contrast, our analysis highlights the importance of taking into account environmental and economic opportunities in explaining household adaptation choices. We surveyed over 750 households arrayed along an ecological gradient and matched across the national border in Mongolia and the Inner Mongolia Autonomous Region, China, asking what changes in livelihoods strategies households made over the last ten years, and analyzed these choices in two broad categories of options: diversification and livestock management. We combined these data with remotely sensed information about vegetation growth and self-reported exposure to price fluctuations. Our statistical results showed that households experiencing lower ecological and economic variability, higher average levels of vegetation growth, and with greater levels of material wealth, were often those that undertook more actions to improve their conditions in the face of variability. The findings have implications both for how interventions aimed at supporting ongoing choices might be targeted and for theory construction related to social adaptation. PMID:24910710

  13. Use of comparative genomics approaches to characterize interspecies differences in response to environmental chemicals: Challenges, opportunities, and research needs

    SciTech Connect

    Burgess-Herbert, Sarah L.; Euling, Susan Y.

    2013-09-15

    A critical challenge for environmental chemical risk assessment is the characterization and reduction of uncertainties introduced when extrapolating inferences from one species to another. The purpose of this article is to explore the challenges, opportunities, and research needs surrounding the issue of how genomics data and computational and systems level approaches can be applied to inform differences in response to environmental chemical exposure across species. We propose that the data, tools, and evolutionary framework of comparative genomics be adapted to inform interspecies differences in chemical mechanisms of action. We compare and contrast existing approaches, from disciplines as varied as evolutionary biology, systems biology, mathematics, and computer science, that can be used, modified, and combined in new ways to discover and characterize interspecies differences in chemical mechanism of action which, in turn, can be explored for application to risk assessment. We consider how genetic, protein, pathway, and network information can be interrogated from an evolutionary biology perspective to effectively characterize variations in biological processes of toxicological relevance among organisms. We conclude that comparative genomics approaches show promise for characterizing interspecies differences in mechanisms of action, and further, for improving our understanding of the uncertainties inherent in extrapolating inferences across species in both ecological and human health risk assessment. To achieve long-term relevance and consistent use in environmental chemical risk assessment, improved bioinformatics tools, computational methods robust to data gaps, and quantitative approaches for conducting extrapolations across species are critically needed. Specific areas ripe for research to address these needs are recommended.

  14. Responses to climate and economic risks and opportunities across national and ecological boundaries: changing household strategies on the Mongolian plateau.

    PubMed

    Brown, Daniel G; Agrawal, Arun; Sass, Daniel A; Wang, Jun; Hua, Jin; Xie, Yichun

    2013-01-01

    Climate changes on the Mongolian Plateau are creating new challenges for the households and communities of the region. Much of the existing research on household choices in response to climate variability and change focuses on environmental risks and stresses. In contrast, our analysis highlights the importance of taking into account environmental and economic opportunities in explaining household adaptation choices. We surveyed over 750 households arrayed along an ecological gradient and matched across the national border in Mongolia and the Inner Mongolia Autonomous Region, China, asking what changes in livelihoods strategies households made over the last ten years, and analyzed these choices in two broad categories of options: diversification and livestock management. We combined these data with remotely sensed information about vegetation growth and self-reported exposure to price fluctuations. Our statistical results showed that households experiencing lower ecological and economic variability, higher average levels of vegetation growth, and with greater levels of material wealth, were often those that undertook more actions to improve their conditions in the face of variability. The findings have implications both for how interventions aimed at supporting ongoing choices might be targeted and for theory construction related to social adaptation.

  15. Enhanced response of microbial fuel cell using sulfonated poly ether ether ketone membrane as a biochemical oxygen demand sensor.

    PubMed

    Ayyaru, Sivasankaran; Dharmalingam, Sangeetha

    2014-03-25

    The present study is focused on the development of single chamber microbial fuel cell (SCMFC) using sulfonated poly ether ether ketone (SPEEK) membrane to determine the biochemical oxygen demand (BOD) matter present in artificial wastewater (AW). The biosensor produces a good linear relationship with the BOD concentration up to 650 ppm when using artificial wastewater. This sensing range was 62.5% higher than that of Nafion(®). The most serious problem in using MFC as a BOD sensor is the oxygen diffusion into the anode compartment, which consumes electrons in the anode compartment, thereby reducing the coulomb yield and reducing the electrical signal from the MFC. SPEEK exhibited one order lesser oxygen permeability than Nafion(®), resulting in low internal resistance and substrate loss, thus improving the sensing range of BOD. The system was further improved by making a double membrane electrode assembly (MEA) with an increased electrode surface area which provide high surface area for electrically active bacteria.

  16. Review of current Southern California edison load management programs and proposal for a new market-driven, mass-market, demand-response program

    SciTech Connect

    Weller, G.H.

    2002-01-01

    Utility load management programs, including direct load control and interruptible load programs, constitute a large installed base of controllable loads that are employed by utilities as system reliability resources. In response to energy supply shortfalls expected during the summer of 2001, the California Public Utilities Commission in spring 2001 authorized new utility load management programs as well as revisions to existing programs. This report provides an independent review of the designs of these new programs for a large utility (Southern California Edison) and suggests possible improvements to enhance the price responsiveness of the customer actions influenced by these programs. The report also proposes a new program to elicit a mass-market demand response to utility price signals.

  17. How Can I Clarify My Responsibility as a Headteacher as I Provide Opportunities to Enable All Children in the School to Create Talents?

    ERIC Educational Resources Information Center

    Cripps, Louise

    2013-01-01

    In this account I explore and clarify my responsibility as I explain how I have come to my current understanding of talent creation, and why I feel it is so important to develop an inclusive approach to talent creation which provides opportunities for all the children to develop talents through their time at school, and to have them recognised and…

  18. Response of Bean (Vicia faba L.) Plants to Low Sink Demand by Measuring the Gas Exchange Rates and Chlorophyll a Fluorescence Kinetics

    PubMed Central

    Liu, Guo-Tian; Xu, Hong-Guo; Wang, Li-Jun; Li, Shao-Hua

    2013-01-01

    Background The decline of photosynthesis in plants under low sink demand is well known. Previous studies focused on the relationship between stomatal conductance (gs) and net photosynthetic rate (Pn). These studies investigated the effect of changes in Photosystem II (PSII) function on the Pn decline under low sink demand. However, little is known about its effects on different limiting steps of electron transport chain in PSII under this condition. Methodology/Principal Finding Two-month-old bean plants were processed by removing pods and flowers (low sink demand). On the 1st day after low sink demand treatment, a decline of Pn was accompanied by a decrease in gs and internal-to-ambient CO2 concentration ratio (Ci/Ca). From the 3rd to 9th day, Pn and gs declined continuously while Ci/Ca ratio remained stable in the treatment. Moreover, these values were lower than that of control. Wk (a parameter reflecting the damage to oxygen evolving complex of the donor side of PSII) values in the treatment were significantly higher than their corresponding control values. However, RCQA (a parameter reflecting the number of active RCs per excited cross-section of PSII) values in the treatment were significantly lower than control from the 5th day. From the 11th to 21st day, Pn and gs of the treatment continued to decline and were lower than control. This was accompanied by a decrease of RCQA, and an increase of Wk. Furthermore, the quantum yield parameters φPo, φEo and ψEo in the treatment were lower than in control; however, Ci/Ca values in the treatment gradually increased and were significantly higher than control on the 21st day. Conclusions Stomatal limitation during the early stage, whereas a combination of stomatal and non-stomatal limitation during the middle stage might be responsible for the reduction of Pn under low sink demand. Non-stomatal limitation during the late stages after the removal of the sink of roots and pods may also cause Pn reduction. The non

  19. Demographic Problems and Opportunities.

    ERIC Educational Resources Information Center

    Osborn, Frances P.

    A comparison of Monroe County projections of high school graduates and the March 1986 Rochester Labor Area Summary points to some excellent opportunities for marketing Monroe Community College (MCC). Projections of high school graduation rates show a 25% decrease in the number of graduates between 1989 and 1991, while the demand for entry-level…

  20. Flexible Learning Opportunities.

    ERIC Educational Resources Information Center

    Further Education Unit, London (England).

    One way for colleges to meet the demand for a wider range of learning opportunities for adults in Great Britain is to provide more flexibility within the further education system. The concept of flexible learning involves the modification of delivery systems, specific providing agencies, target populations, specific determinants such as geographic…

  1. Harnessing the power of demand

    SciTech Connect

    Sheffrin, Anjali; Yoshimura, Henry; LaPlante, David; Neenan, Bernard

    2008-03-15

    Demand response can provide a series of economic services to the market and also provide ''insurance value'' under low-likelihood, but high-impact circumstances in which grid reliablity is enhanced. Here is how ISOs and RTOs are fostering demand response within wholesale electricity markets. (author)

  2. Task demands modulate decision and eye movement responses in the chimeric face test: examining the right hemisphere processing account.

    PubMed

    Coronel, Jason C; Federmeier, Kara D

    2014-01-01

    A large and growing body of work, conducted in both brain-intact and brain-damaged populations, has used the free viewing chimeric face test as a measure of hemispheric dominance for the extraction of emotional information from faces. These studies generally show that normal right-handed individuals tend to perceive chimeric faces as more emotional if the emotional expression is presented on the half of the face to the viewer's left ("left hemiface"). However, the mechanisms underlying this lateralized bias remain unclear. Here, we examine the extent to which this bias is driven by right hemisphere processing advantages vs. default scanning biases in a unique way-by changing task demands. In particular, we compare the original task with one in which right-hemisphere-biased processing cannot provide a decision advantage. Our behavioral and eye movement data are inconsistent with the predictions of a default scanning bias account and support the idea that the left hemiface bias found in the chimeric face test is largely due to strategic use of right hemisphere processing mechanisms.

  3. 49 CFR 37.171 - Equivalency requirement for demand responsive service operated by private entities not primarily...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... service operated by private entities not primarily engaged in the business of transporting people. 37.171... responsive service operated by private entities not primarily engaged in the business of transporting people. A private entity not primarily engaged in the business of transporting people which operates...

  4. 49 CFR 37.171 - Equivalency requirement for demand responsive service operated by private entities not primarily...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... service operated by private entities not primarily engaged in the business of transporting people. 37.171... responsive service operated by private entities not primarily engaged in the business of transporting people. A private entity not primarily engaged in the business of transporting people which operates...

  5. Foodborne disease outbreak in a resource-limited setting: a tale of missed opportunities and implications for response

    PubMed Central

    Ameme, Donne Kofi; Abdulai, Marijanatu; Adjei, Eric Yirenkyi; Afari, Edwin Andrews; Nyarko, Kofi Mensah; Asante, Dwamena; Kye-Duodu, Gideon; Abbas, Mona; Sackey, Samuel; Wurapa, Fred

    2016-01-01

    Introduction Foodborne diseases (FBD) have emerged as a major public health problem worldwide. Though the global burden of FBD is currently unknown, foodborne diarrhoeal diseases kill 1.9 million children globally every year. On 25th September 2014, health authorities in Eastern Region of Ghana were alerted of a suspected FBD outbreak involving patrons of a community food joint. We investigated to determine the magnitude, source and implement control and preventive measures. Methods A retrospective cohort study was conducted. We reviewed medical records for data on demographics and clinical features. A suspected foodborne disease was any person in the affected community with abdominal pain, vomiting and or diarrhea between 25th and 30th September 2014 and had eaten from the food joint. We conducted active case search, descriptive data analysis and calculated food specific attack rate ratios (ARR) and their corresponding 95% confidence intervals. Results Of 43 case-patients, 44.2% (19/43) were males; median age was 19 years (interquartile range: 17-24 years). Overall attack rate was 43.4% (43/99) with no fatality. Case counts rose sharply for four hours to a peak and fell to baseline levels after 12 hours. Compared to those who ate other food items, patrons who ate “waakye” and “shitor” were more likely to develop foodborne disease [ARR = 4.1 (95% CI = 1.09-15.63)]. Food samples and specimens from case-patients were unavailable for testing. Laboratory diagnostic capacity was also weak. Conclusion A point source FBD outbreak linked to probable contaminated “waakye” and or “shitor” occurred. Missed opportunities for definitive diagnosis highlighted the need for strengthening local response capacity. PMID:27217893

  6. Responses to a 120 min reserve team soccer match: a case study focusing on the demands of extra time.

    PubMed

    Russell, Mark; Sparkes, William; Northeast, Jonathan; Kilduff, Liam Patrick

    2015-01-01

    The movement demands of the soccer extra time period are unknown despite the importance of this period of play. Data are presented for five English Premier League reserve team players who wore GPS (10 Hz) monitors during an official soccer match that required extra time to be played. Countermovement jump performance (peak power output (PPO) and jump height) and creatine kinase (CK) concentrations were assessed before (-24 h; baseline) and after (+24 h, +48 h) match play. Players covered 14,106 ± 859 m (109 ± 7 m·min(-1)) throughout the game. From 90 to 120 min, 3213 ± 286 m were covered and 12 ± 6 sprints, 221 ± 14 accelerations and 207 ± 16 decelerations occurred. From 105 to 120 min, acceleration and deceleration parameters reduced by >10% compared to the opening 15 min. At +24 h and +48 h, PPO reduced by 416.1 ± 199.9 W (10.9% ± 4.4%) and 155.1 ± 34.8 W (4.1% ± 0.8%), jump heights decreased by 0.064 ± 0.046 m (17.8% ± 11.2%) and 0.025 ± 0.009 m (7.4% ± 3.2%), whereas CK increased by 586.6 ± 85.1 μ·l(-1) (236% ± 92%) and 266.8 ± 134.7 μ·l(-1) (107% ± 89%) versus baseline, respectively. Physical performance markers reduced throughout match play and countermovement jump performance was impaired, while CK remained elevated, for at least 48 h after the game. Interventions which maintain performance throughout a game and which enhance recovery in the days after 120 min of soccer match play warrant further investigation. PMID:26148212

  7. Distribution of Childrearing Demands.

    ERIC Educational Resources Information Center

    Zimmerman, Judith D.; And Others

    The tools of economic analysis were applied to demographic data in order to develop a social indicator measuring the extent of inequality in the distribution of childrearing responsibility in households from 1940 to 1980. With data drawn from the Current Population Survey of the Bureau of the Census, a "demand intensity" measure was developed.…

  8. Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes.

    PubMed

    Gutowski, Stacie M; Shoemaker, James T; Templeman, Kellie L; Wei, Yang; Latour, Robert A; Bellamkonda, Ravi V; LaPlaca, Michelle C; García, Andrés J

    2015-03-01

    Neural electrodes are an important part of brain-machine interface devices that can restore functionality to patients with sensory and movement disorders. Chronically implanted neural electrodes induce an unfavorable tissue response which includes inflammation, scar formation, and neuronal cell death, eventually causing loss of electrode function. We developed a poly(ethylene glycol) hydrogel coating for neural electrodes with non-fouling characteristics, incorporated an anti-inflammatory agent, and engineered a stimulus-responsive degradable portion for on-demand release of the anti-inflammatory agent in response to inflammatory stimuli. This coating reduces in vitro glial cell adhesion, cell spreading, and cytokine release compared to uncoated controls. We also analyzed the in vivo tissue response using immunohistochemistry and microarray qRT-PCR. Although no differences were observed among coated and uncoated electrodes for inflammatory cell markers, lower IgG penetration into the tissue around PEG+IL-1Ra coated electrodes indicates an improvement in blood-brain barrier integrity. Gene expression analysis showed higher expression of IL-6 and MMP-2 around PEG+IL-1Ra samples, as well as an increase in CNTF expression, an important marker for neuronal survival. Importantly, increased neuronal survival around coated electrodes compared to uncoated controls was observed. Collectively, these results indicate promising findings for an engineered coating to increase neuronal survival and improve tissue response around implanted neural electrodes.

  9. Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes.

    PubMed

    Gutowski, Stacie M; Shoemaker, James T; Templeman, Kellie L; Wei, Yang; Latour, Robert A; Bellamkonda, Ravi V; LaPlaca, Michelle C; García, Andrés J

    2015-03-01

    Neural electrodes are an important part of brain-machine interface devices that can restore functionality to patients with sensory and movement disorders. Chronically implanted neural electrodes induce an unfavorable tissue response which includes inflammation, scar formation, and neuronal cell death, eventually causing loss of electrode function. We developed a poly(ethylene glycol) hydrogel coating for neural electrodes with non-fouling characteristics, incorporated an anti-inflammatory agent, and engineered a stimulus-responsive degradable portion for on-demand release of the anti-inflammatory agent in response to inflammatory stimuli. This coating reduces in vitro glial cell adhesion, cell spreading, and cytokine release compared to uncoated controls. We also analyzed the in vivo tissue response using immunohistochemistry and microarray qRT-PCR. Although no differences were observed among coated and uncoated electrodes for inflammatory cell markers, lower IgG penetration into the tissue around PEG+IL-1Ra coated electrodes indicates an improvement in blood-brain barrier integrity. Gene expression analysis showed higher expression of IL-6 and MMP-2 around PEG+IL-1Ra samples, as well as an increase in CNTF expression, an important marker for neuronal survival. Importantly, increased neuronal survival around coated electrodes compared to uncoated controls was observed. Collectively, these results indicate promising findings for an engineered coating to increase neuronal survival and improve tissue response around implanted neural electrodes. PMID:25617126

  10. Nutrient demand interacts with grass maturity to affect milk fat concentration and digestion responses in dairy cows.

    PubMed

    Kammes, K L; Allen, M S

    2012-09-01

    Effects of grass maturity on dry matter intake (DMI), milk production, ruminal fermentation and pool sizes, digestion and passage kinetics, and chewing activity and the relationship of these effects with preliminary DMI (pDMI) were evaluated using 13 ruminally and duodenally cannulated Holstein cows in a crossover design with a 14-d preliminary period and two 18-d treatment periods. During the preliminary period, pDMI of individual cows ranged from 23.5 to 28.2 kg/d (mean=26.1 kg/d) and 3.5% fat-corrected milk (FCM) yield ranged from 30.8 to 57.2 kg/d (mean=43.7 kg/d). Experimental treatments were diets containing orchardgrass silage harvested either (1) early-cut, less mature (EC) or (2) late-cut, more mature (LC) as the sole forage. Early- and late-cut orchardgrass contained 44.9 and 54.4% neutral detergent fiber (NDF) and 20.1 and 15.3% crude protein, respectively. Forage:concentrate ratio was 58:42 and 46:54 for EC and LC, respectively; both diets contained approximately 25% forage NDF and 30% total NDF. Preliminary DMI, an index of nutrient demand, was determined during the last 4d of the preliminary period when cows were fed a common diet and used as a covariate. Main effects of grass maturity and their interaction with pDMI were tested by ANOVA. The EC diet decreased milk yield and increased milk fat concentration compared with the LC diet. Grass maturity and its interaction with pDMI did not affect FCM yield, DMI, rumen pH, or microbial efficiency. The EC diet increased rates of ruminal digestion of potentially digestible NDF and passage of indigestible NDF (iNDF) compared with the LC diet. The lower concentration and faster passage rate of iNDF for EC resulted in lower rumen pools of iNDF, total NDF, organic matter, and dry matter for EC than LC. Ruminal passage rates of potentially digestible NDF and starch were related to level of intake (quadratic and linear interactions, respectively) and subsequently affected ruminal digestibility of these nutrients

  11. Facing a Clever Predator Demands Clever Responses - Red-Backed Shrikes (Lanius collurio) vs. Eurasian Magpies (Pica pica)

    PubMed Central

    Syrová, Michaela; Němec, Michal; Veselý, Petr; Landová, Eva; Fuchs, Roman

    2016-01-01

    Red-backed shrikes (Lanius collurio) behave quite differently towards two common nest predators. While the European jay (Garrulus glandarius) is commonly attacked, in the presence of the Eurasian magpie (Pica pica), shrikes stay fully passive. We tested the hypotheses that this passive response to the magpie is an alternative defense strategy. Nesting shrikes were exposed to the commonly attacked European kestrel (Falco tinnunculus) in a situation in which i) a harmless domestic pigeon, ii) a commonly attacked European jay, and iii) a non-attacked black-billed magpie are (separately) presented nearby. The kestrel dummy presented together with the magpie dummy was attacked with a significantly lower intensity than when it was presented with the other intruders (pigeon, jay) or alone. This means that the presence of the magpie inhibited the shrike’s defense response towards the other intruder. These results support our previous hypotheses that shrikes use an alternative defense strategy in the magpie’s presence. We hypothesize that the magpie is able to associate the active defense of the shrikes with the close proximity of a nest and that shrikes try not to draw the magpie’s attention to the nest. The reason why this strategy is not used against the jay remains unanswered as jays as well as magpies show very similar cognitive and foraging skills enabling them to individuate the nest presence according to active parental defense. PMID:27454122

  12. Moderating effects of salivary testosterone levels on associations between job demand and psychological stress response in Japanese medical workers

    PubMed Central

    HIROKAWA, Kumi; MIWA, Machiko; TANIGUCHI, Toshiyo; TSUCHIYA, Masao; KAWAKAMI, Norito

    2015-01-01

    Levels of job stress have been shown to be inversely associated with testosterone levels, but some inconsistent results have been documented. We investigated the moderating effects of testosterone levels on associations between job stress-factors and psychological stress responses in Japanese medical workers. The participants were 63 medical staff (20 males and 43 women; mean age: 30.6 years; SD=7.3) in Okayama, Japan. Their job-stress levels and psychological stress responses were evaluated using self-administered questionnaires, and their salivary testosterone collected. Multiple regression analyses showed that job demand was positively associated with stress responses in men and women. An interaction between testosterone and support from colleagues had a significant effect on depression and anxiety for women. In women with lower testosterone levels, a reducing effect of support from colleagues on depression and anxiety was intensified. In women with higher testosterone levels, depression and anxiety levels were identical regardless of support from colleagues. Testosterone may function as a moderator between perceived work environment and psychological stress responses for female medical workers. PMID:26632120

  13. Prioritizing blood flow: cardiovascular performance in response to the competing demands of locomotion and digestion for the Burmese python, Python molurus.

    PubMed

    Secor, Stephen M; White, Scott E

    2010-01-01

    Individually, the metabolic demands of digestion or movement can be fully supported by elevations in cardiovascular performance, but when occurring simultaneously, vascular perfusion may have to be prioritized to either the gut or skeletal muscles. Burmese pythons (Python molurus) experience similar increases in metabolic rate during the digestion of a meal as they do while crawling, hence each would have an equal demand for vascular supply when these two actions are combined. To determine, for the Burmese python, whether blood flow is prioritized when snakes are digesting and moving, we examined changes in cardiac performance and blood flow in response to digestion, movement, and the combination of digestion and movement. We used perivascular blood flow probes to measure blood flow through the left carotid artery, dorsal aorta, superior mesenteric artery and hepatic portal vein, and to calculate cardiac output, heart rate and stroke volume. Fasted pythons while crawling experienced a 2.7- and 3.3-fold increase, respectively, in heart rate and cardiac output, and a 66% decrease in superior mesenteric flow. During the digestion of a rodent meal equaling in mass to 24.7% of the snake's body mass, heart rate and cardiac output increased by 3.3- and 4.4-fold, respectively. Digestion also resulted in respective 11.6- and 14.1-fold increases in superior mesenteric and hepatic portal flow. When crawling while digesting, cardiac output and dorsal aorta flow increased by only 21% and 9%, respectively, a modest increase compared with that when they start to crawl on an empty stomach. Crawling did triggered a significant reduction in blood flow to the digesting gut, decreasing superior mesenteric and hepatic portal flow by 81% and 47%, respectively. When faced with the dual demands of digestion and crawling, Burmese pythons prioritize blood flow, apparently diverting visceral supply to the axial muscles.

  14. The Responses of Medical General Practitioners to Unreasonable Patient Demand for Antibiotics - A Study of Medical Ethics Using Immersive Virtual Reality

    PubMed Central

    Pan, Xueni; Slater, Mel; Beacco, Alejandro; Navarro, Xavi; Bellido Rivas, Anna I.; Swapp, David; Hale, Joanna; Forbes, Paul Alexander George; Denvir, Catrina; de C. Hamilton, Antonia F.; Delacroix, Sylvie

    2016-01-01

    Background Dealing with insistent patient demand for antibiotics is an all too common part of a General Practitioner’s daily routine. This study explores the extent to which portable Immersive Virtual Reality technology can help us gain an accurate understanding of the factors that influence a doctor’s response to the ethical challenge underlying such tenacious requests for antibiotics (given the threat posed by growing anti-bacterial resistance worldwide). It also considers the potential of such technology to train doctors to face such dilemmas. Experiment Twelve experienced GPs and nine trainees were confronted with an increasingly angry demand by a woman to prescribe antibiotics to her mother in the face of inconclusive evidence that such antibiotic prescription is necessary. The daughter and mother were virtual characters displayed in immersive virtual reality. The specific purposes of the study were twofold: first, whether experienced GPs would be more resistant to patient demands than the trainees, and second, to investigate whether medical doctors would take the virtual situation seriously. Results Eight out of the 9 trainees prescribed the antibiotics, whereas 7 out of the 12 GPs did so. On the basis of a Bayesian analysis, these results yield reasonable statistical evidence in favor of the notion that experienced GPs are more likely to withstand the pressure to prescribe antibiotics than trainee doctors, thus answering our first question positively. As for the second question, a post experience questionnaire assessing the participants’ level of presence (together with participants’ feedback and body language) suggested that overall participants did tend towards the illusion of being in the consultation room depicted in the virtual reality and that the virtual consultation taking place was really happening. PMID:26889676

  15. Impacts of Demand-Side Resources on Electric Transmission Planning

    SciTech Connect

    Hadley, Stanton W.; Sanstad, Alan H.

    2015-01-01

    Will demand resources such as energy efficiency (EE), demand response (DR), and distributed generation (DG) have an impact on electricity transmission requirements? Five drivers for transmission expansion are discussed: interconnection, reliability, economics, replacement, and policy. With that background, we review the results of a set of transmission studies that were conducted between 2010 and 2013 by electricity regulators, industry representatives, and other stakeholders in the three physical interconnections within the United States. These broad-based studies were funded by the US Department of Energy and included scenarios of reduced load growth due to EE, DR, and DG. While the studies were independent and used different modeling tools and interconnect-specific assumptions, all provided valuable results and insights. However, some caveats exist. Demand resources were evaluated in conjunction with other factors, and limitations on transmission additions between scenarios made understanding the role of demand resources difficult. One study, the western study, included analyses over both 10- and 20-year planning horizons; the 10-year analysis did not show near-term reductions in transmission, but the 20-year indicated fewer transmission additions, yielding a 36percent capital cost reduction. In the eastern study the reductions in demand largely led to reductions in local generation capacity and an increased opportunity for low-cost and renewable generation to export to other regions. The Texas study evaluated generation changes due to demand, and is in the process of examining demand resource impacts on transmission.

  16. Improving the simultaneous removal of chemical oxygen demand and terephthalic acid in a cross-flow aerobic sludge reactor by using response surface methodology.

    PubMed

    Hu, Dong-Xue; Tian, Yu; Chen, Zhao-Bo; Ge, Hui; Cui, Yu-Bo; Ran, Chun-Qiu

    2015-01-01

    Central composite design and response surface methodology (RSM) were implemented to optimize the operational parameters for a cross-flow aerobic sludge reactor (CFASR) in remedying mixed printing and dyeing wastewater (MPDW). The individual and interactive effects of three variables, hydraulic retention time (HRT), pH and sludge loading rate (SLR), on chemical oxygen demand (COD) and terephthalic acid (TA) removal rates were evaluated. For HRT of 15.3-19.8 hours, pH of 7.2-8.1 and SLR of 0.4-0.6 kg chemical oxygen demand (COD) per kg mixed liquor suspended solids per day, COD and TA removal rates of the CFASR exceeded 85% and 90%, respectively. The check experiment revealed that the effluent from the optimized CFASR was stable below the limitation of 100 mg COD/L and the TA concentration decreased by 6.0% compared to the usual CFASR. The results verified that the RSM was useful for optimizing the operation parameters of the CFASR in remedying MPDW.

  17. Poplar demand.

    PubMed

    Holton, W C

    1998-09-01

    Trichloroethylene (TCE) is a common industrial solvent that poses a particular pollution problem in groundwater; while TCE disappears from surface water within a few weeks, groundwater contamination can take months or years to degrade. Humans have not conclusively been shown to develop cancer in response to TCE exposure, but rats and mice exposed to TCE have an increased incidence of liver and lung cancers.

  18. Learning through Expeditions: The Need for Method as Well as Opportunity--A Response to Allison and Von Wald (2010)

    ERIC Educational Resources Information Center

    Tozer, Mark; Collins, Dave; Hathaway, Tanya

    2011-01-01

    Allison and Von Wald (2010) highlight the substantial opportunities presented by expeditions to address the crucial topic of personal and social development. The present paper wishes to address the apparent oversight of transfer within such learning experiences. Issues that need to be addressed if the impact of transfer is to be optimised are…

  19. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer.

    PubMed

    Ma, Tian; Galimberti, Fabrizio; Erkmen, Cherie P; Memoli, Vincent; Chinyengetere, Fadzai; Sempere, Lorenzo; Beumer, Jan H; Anyang, Bean N; Nugent, William; Johnstone, David; Tsongalis, Gregory J; Kurie, Jonathan M; Li, Hua; Direnzo, James; Guo, Yongli; Freemantle, Sarah J; Dragnev, Konstantin H; Dmitrovsky, Ethan

    2013-08-01

    Histone deacetylase inhibitor (HDACi; vorinostat) responses were studied in murine and human lung cancer cell lines and genetically engineered mouse lung cancer models. Findings were compared with a window of opportunity trial in aerodigestive tract cancers. In human (HOP62, H522, and H23) and murine transgenic (ED-1, ED-2, LKR-13, and 393P, driven, respectively, by cyclin E, degradation-resistant cyclin E, KRAS, or KRAS/p53) lung cancer cell lines, vorinostat reduced growth, cyclin D1, and cyclin E levels, but induced p27, histone acetylation, and apoptosis. Other biomarkers also changed. Findings from transgenic murine lung cancer models were integrated with those from a window of opportunity trial that measured vorinostat pharmacodynamic responses in pre- versus posttreatment tumor biopsies. Vorinostat repressed cyclin D1 and cyclin E expression in murine transgenic lung cancers and significantly reduced lung cancers in syngeneic mice. Vorinostat also reduced cyclin D1 and cyclin E expression, but increased p27 levels in post- versus pretreatment human lung cancer biopsies. Notably, necrotic and inflammatory responses appeared in posttreatment biopsies. These depended on intratumoral HDACi levels. Therefore, HDACi treatments of murine genetically engineered lung cancer models exert similar responses (growth inhibition and changes in gene expression) as observed in lung cancer cell lines. Moreover, enhanced pharmacodynamic responses occurred in the window of opportunity trial, providing additional markers of response that can be evaluated in subsequent HDACi trials. Thus, combining murine and human HDACi trials is a strategy to translate preclinical HDACi treatment outcomes into the clinic. This study uncovered clinically tractable mechanisms to engage in future HDACi trials.

  20. Seizing Opportunity: "Opportunity as Transformation"

    ERIC Educational Resources Information Center

    Williams, Michael; Muller, Esther

    2012-01-01

    Opportunity creates conditions for achievement. We learn daily of the success of others that resulted from conditions they created through opportunity. Often these conditions of opportunity are the product of a compelling vision of a future steeped in possibility and rich in reward. These visions, however, must be operationalized in order to be…

  1. Composition-property relationships in multifunctional hollow mesoporous carbon nanosystems for PH-responsive magnetic resonance imaging and on-demand drug release

    NASA Astrophysics Data System (ADS)

    Zhang, Shengjian; Qian, Xiaoqing; Zhang, Linlin; Peng, Weijun; Chen, Yu

    2015-04-01

    The construction of intelligent stimuli-responsive nanosystems can substantially improve the sensitivity/resolution/specificity of diagnostic imaging and enhance the therapeutic efficiency of chemotherapy for cancer treatment. This work reports on a generic construction strategy to achieve a multiple stimuli-responsive theranostic system for cancer simply by optimizing the chemical compositions of inorganic nanoplatforms to avoid the tedious and complicated synthetic procedure for traditional organic or organic/inorganic nanosystems. Based on the ``breaking up'' nature of manganese oxides and specific features of the carbonaceous framework to interact with aromatic drug molecules, manganese oxide nanoparticles were elaborately integrated into hollow mesoporous carbon nanocapsules by a simple in situ framework redox strategy to realize concurrent pH-sensitive T1-weighted magnetic resonance imaging (MRI) and pH-/HIFU-responsive on-demand drug release. The ultrasensitive disease-triggered MRI performance has been successfully demonstrated by a 52.5-fold increase of longitudinal relaxivity (r1 = 10.5 mM-1 s-1) and on nude mice 4T1 xenograft. The pH- and HIFU-triggered doxorubicin release and enhanced therapeutic outcome against multidrug resistance of cancer cells were systematically confirmed. In particular, the fabricated inorganic composite nanocapsules were found to feature unique biological behaviours, such as antimetastasis effect, extremely low hemolysis against red blood cells and high in vivo histocompatibility. This report on the successful construction of a pure inorganic nanosystem with multiple stimuli-responsivenesses may pave the way to new methods for the development of intelligent nanofamilies for cancer therapy.The construction of intelligent stimuli-responsive nanosystems can substantially improve the sensitivity/resolution/specificity of diagnostic imaging and enhance the therapeutic efficiency of chemotherapy for cancer treatment. This work reports

  2. Composition-property relationships in multifunctional hollow mesoporous carbon nanosystems for PH-responsive magnetic resonance imaging and on-demand drug release.

    PubMed

    Zhang, Shengjian; Qian, Xiaoqing; Zhang, Linlin; Peng, Weijun; Chen, Yu

    2015-05-01

    The construction of intelligent stimuli-responsive nanosystems can substantially improve the sensitivity/resolution/specificity of diagnostic imaging and enhance the therapeutic efficiency of chemotherapy for cancer treatment. This work reports on a generic construction strategy to achieve a multiple stimuli-responsive theranostic system for cancer simply by optimizing the chemical compositions of inorganic nanoplatforms to avoid the tedious and complicated synthetic procedure for traditional organic or organic/inorganic nanosystems. Based on the "breaking up" nature of manganese oxides and specific features of the carbonaceous framework to interact with aromatic drug molecules, manganese oxide nanoparticles were elaborately integrated into hollow mesoporous carbon nanocapsules by a simple in situ framework redox strategy to realize concurrent pH-sensitive T1-weighted magnetic resonance imaging (MRI) and pH-/HIFU-responsive on-demand drug release. The ultrasensitive disease-triggered MRI performance has been successfully demonstrated by a 52.5-fold increase of longitudinal relaxivity (r1 = 10.5 mM(-1) s(-1)) and on nude mice 4T1 xenograft. The pH- and HIFU-triggered doxorubicin release and enhanced therapeutic outcome against multidrug resistance of cancer cells were systematically confirmed. In particular, the fabricated inorganic composite nanocapsules were found to feature unique biological behaviours, such as antimetastasis effect, extremely low hemolysis against red blood cells and high in vivo histocompatibility. This report on the successful construction of a pure inorganic nanosystem with multiple stimuli-responsivenesses may pave the way to new methods for the development of intelligent nanofamilies for cancer therapy.

  3. Conditioned Demand and Professional Response.

    ERIC Educational Resources Information Center

    Rhoades, Gary

    1984-01-01

    Two basic features of British higher education administration bearing on the workability of recent Leverhulme study proposals for the future of British higher education are examined. Vertical integration, (the relationship of secondary and higher education systems) and a high degree of professionalism enhancing it will influence reforms…

  4. Teaching Social Media Journalism: Challenges and Opportunities for Future Curriculum Design

    ERIC Educational Resources Information Center

    Bor, Stephanie E.

    2014-01-01

    In response to the growing demand for digitally competent employees in the news media industry, journalism schools are cautiously integrating social media reporting into their curriculum. This study explores techniques for teaching news reporting on social media platforms focusing on challenges and opportunities for learning engagement that…

  5. Responses of the red blood cells from two high-energy-demand teleosts, yellowfin tuna (Thunnus albacares) and skipjack tuna (Katsuwonus pelamis), to catecholamines.

    PubMed

    Lowe, T E; Brill, R W; Cousins, K L

    1998-08-01

    affinity of yellowfin tuna blood. Our results, therefore, do not support our original hypothesis. The catecholamine response of red blood cells from high-energy-demand teleosts (i.e., tunas) is not enhanced compared to other teleosts. There are data on changes in cardio-respiratory function in tunas caused by acute hypoxia and modest increases in activity, but there are no data on the changes in cardio-respiratory function in tunas accompanying the large increases in metabolic rate seen during recovery from exhaustive exercise. However, we conclude that during those instances where high rates of O2 delivery to the tissues are needed, tunas' ability to increase cardiac output, ventilation volume, blood O2 carrying capacity, and effective respiratory (i.e., gill) surface area are probably more important than are the responses of red blood cells to catecholamines. We also use our data to investigate the extent of the Haldane effect and its relationship to blood O2 and CO2 transport in yellowfin tuna. Yellowfin tuna blood shows a large Haldane effect; intracellular pH increases 0.20 units during oxygenation. The largest change in intracellular pH occurs between 40-100% O2 saturation, indicating that yellowfin tuna, like other teleosts, fully exploit the Haldane effect over the normal physiological range of blood O2 saturation. PMID:9747521

  6. Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA); interpretation of "federal means-tested public benefit"--HHS. Notice with comment period.

    PubMed

    1997-08-26

    This notice with comment period interprets the term "Federal means-tested public benefit[s]" as used in Title IV of the Personal Responsibility and work Opportunity Reconciliation Act of 1996 (PRWORA), Pub. L. 104-193, to include only mandatory spending programs of the Federal Government in which eligibility for the program's benefits, or the amount of such benefits or both, are determined on the basis of income or resources of the eligibility unit seeking the benefit. At HHS, the benefit programs that fall within this definition (and are not explicitly excerted from the definition by Section 403 (c)) are Medicaid and Temporary Assistance for Needy Families (TANF).

  7. Solar Energy Grid Integration Systems. Final Report of the Princeton Power Systems Development of the 100kW Demand Response Inverter.

    SciTech Connect

    Bower, Ward Isaac; Heavener, Paul; Sena-Henderson, Lisa; Hammell, Darren; Holveck, Mark; David, Carolyn; Akhil, Abbas Ali; Gonzalez, Sigifredo

    2012-01-01

    Initiated in 2008, the Solar Energy Grid Integration (SEGIS) program is a partnership involving the U.S. Department of Energy, Sandia National Laboratories, electric utilities, academic institutions and the private sector. Recognizing the need to diversify the nation's energy portfolio, the SEGIS effort focuses on specific technologies needed to facilitate the integration of large-scale solar power generation into the nation's power grid Sandia National Laboratories (SNL) awarded a contract to Princeton Power Systems, Inc., (PPS) to develop a 100kW Advanced AC-link SEGIS inverter prototype under the Department of Energy Solar Energy Technologies Program for near-term commercial applications. This SEGIS initiative emphasizes the development of advanced inverters, controllers, communications and other balance-of-system components for photovoltaic (PV) distributed power applications. The SEGIS Stage 3 Contract was awarded to PPS on July 28, 2010. PPS developed and implemented a Demand Response Inverter (DRI) during this three-stage program. PPS prepared a 'Site Demonstration Conference' that was held on September 28, 2011, to showcase the cumulative advancements. This demo of the commercial product will be followed by Underwriters Laboratories, Inc., certification by the fourth quarter of 2011, and simultaneously the customer launch and commercial production sometime in late 2011 or early 2012. This final report provides an overview of all three stages and a full-length reporting of activities and accomplishments in Stage 3.

  8. Cellular defense system gene expression profiling of human whole blood: opportunities to predict health benefits in response to diet.

    PubMed

    Drew, Janice E

    2012-07-01

    Diet is a critical factor in the maintenance of human cellular defense systems, immunity, inflammation, redox regulation, metabolism, and DNA repair that ensure optimal health and reduce disease risk. Assessment of dietary modulation of cellular defense systems in humans has been limited due to difficulties in accessing target tissues. Notably, peripheral blood gene expression profiles associated with nonhematologic disease are detectable. Coupled with recent innovations in gene expression technologies, gene expression profiling of human blood to determine predictive markers associated with health status and dietary modulation is now a feasible prospect for nutrition scientists. This review focuses on cellular defense system gene expression profiling of human whole blood and the opportunities this presents, using recent technological advances, to predict health status and benefits conferred by diet. PMID:22797985

  9. Financial Opportunities

    SciTech Connect

    2012-01-19

    The Water Power Program focuses on technological development, and deployment of innovative technologies capable of generating electricity from water. The program funds research and development activities through competitive solicitations. Financial opportunities are avaliable here.

  10. Development of self-assembled molecular structures on polymeric surfaces and their applications as ultrasonically responsive barrier coatings for on-demand, pulsatile drug delivery

    NASA Astrophysics Data System (ADS)

    Kwok, Connie Sau-Kuen

    Nature in the form of DNA, proteins, and cells has the remarkable ability to interact with its environment by processing biological information through specific molecular recognition at the interface. As such, materials that are capable of triggering an appropriate biological response need to be engineered at the biomaterial surface. Chemically and structurally well-defined self-assembled monolayers (SAMs), biomimetics of the lipid bilayer in cell membranes, have been created and studied mostly on rigid metallic surfaces. This dissertation is motivated by the lack of methods to generate a molecularly designed surface for biomedical polymers and thus provides an enabling technology to engineer a polymeric surface precisely at a molecular and cellular level. To take this innovation one step further, we demonstrated that such self-assembled molecular structure coated on drug-containing polymeric devices could act as a stimulus-responsive barrier for controlled drug delivery. A simple, one-step procedure for generating ordered, crystalline methylene chains on polymeric surfaces via urethane linkages was successfully developed. The self-assemblies and molecular structures of these crystalline methylene chains are comparable to the SAM model surfaces, as evidenced by various surface characterization techniques (XPS, TOF-SIMS, and FTIR-ATR). For the first time, these self-assembled molecular structures are shown to function collectively as an ultrasound-responsive barrier membrane for pulsatile drug delivery, including delivery of low-molecular-weight ciprofloxacin and high-molecular-weight insulin. Encouraging results, based on the insulin-activated deoxyglucose uptakes in adipocytes, indicate that the released insulin remained biologically active. Both chemical and acoustic analyses suggest that the ultrasound-assisted release mechanism is primarily induced by transient cavitation, which causes temporary disruption of the self-assembled overlayer, and thus allows

  11. Opportunity fuels

    SciTech Connect

    Lutwen, R.C.

    1994-12-31

    Opportunity fuels - fuels that can be converted to other forms of energy at lower cost than standard fossil fuels - are discussed in outline form. The type and source of fuels, types of fuels, combustability, methods of combustion, refinery wastes, petroleum coke, garbage fuels, wood wastes, tires, and economics are discussed.

  12. Enhancing Opportunities.

    ERIC Educational Resources Information Center

    Meyers, Michelle J.

    1994-01-01

    Hispanics can enhance their professional career by finding jobs with corporations that offer to pay for graduate tuition. This opportunity has positively influenced the careers of many Hispanics and has proven advantageous for corporations as well by increasing the knowledge and skills of their employees. (LP)

  13. Unequal opportunities.

    PubMed

    Trueland, Jennifer

    There are concerns that the reorganisation of the NHS will reduce opportunities for BME nurses to reach senior positions. This article considers the varied experiences of front line nurses. Several have been passed over for promotion, others have experienced overt racism from patients, while some have never felt discriminated against.

  14. Career Paths of Recipients of a Master's Degree in Health Communication: Understanding Employment Opportunities, Responsibilities, and Choices.

    PubMed

    Edgar, Timothy; Silk, Kami J; Abroms, Lorien C; Cruz, Tess Boley; Evans, W Douglas; Gallagher, Susan Scavo; Miller, Gregory A; Hoffman, Alice; Schindler-Ruwisch, Jennifer M; Sheff, Sarah E

    2016-01-01

    A growing number of institutions offer a master's degree in health communication to prepare individuals for applied work in the field, but there is very little literature on the career paths graduates pursue. The current study reports the results of a national survey that targeted the alumni of five institutions that offer the degree. Of the 522 total graduates to whom the survey was sent, 398 responded (76.2% response rate). Results show that the degree recipients have found employment in a wide variety of organizations across the country, including jobs within very prestigious organizations, such as the National Cancer Institute. Common job titles include manager, coordinator, communication associate/specialist, and program/project director. The most common job responsibilities include research activities, the development of health communication materials, project/program management, communication management, and social media/website management. The results also include stories of graduates across programs that illustrate details of career paths. The discussion of the findings addresses implications for career preparation, curriculum development, and advising. PMID:26735802

  15. Functional Linkage between Genes That Regulate Osmotic Stress Responses and Multidrug Resistance Transporters: Challenges and Opportunities for Antibiotic Discovery

    PubMed Central

    2014-01-01

    All cells need to protect themselves against the osmotic challenges of their environment by maintaining low permeability to ions across their cell membranes. This is a basic principle of cellular function, which is reflected in the interactions among ion transport and drug efflux genes that have arisen during cellular evolution. Thus, upon exposure to pore-forming antibiotics such as amphotericin B (AmB) or daptomycin (Dap), sensitive cells overexpress common resistance genes to protect themselves from added osmotic challenges. These genes share pathway interactions with the various types of multidrug resistance (MDR) transporter genes, which both preserve the native lipid membrane composition and at the same time eliminate disruptive hydrophobic molecules that partition excessively within the lipid bilayer. An increased understanding of the relationships between the genes (and their products) that regulate osmotic stress responses and MDR transporters will help to identify novel strategies and targets to overcome the current stalemate in drug discovery. PMID:24295980

  16. High-resolution temperature fields to evaluate the response of Italian electricity demand to meteorological variables: an example of climate service for the energy sector

    NASA Astrophysics Data System (ADS)

    Scapin, Simone; Apadula, Francesco; Brunetti, Michele; Maugeri, Maurizio

    2016-08-01

    The dependence of Italian daily electricity demand on cooling degree-days, heating degree-days and solar radiation is investigated by means of a regression model applied to 12 consecutive 2-year intervals in the 1990-2013 period. The cooling and heating degree-days records used in the model are obtained by (i) estimating, by means of a network of 92 synoptic stations and high-resolution gridded temperature climatologies, a daily effective temperature record for all urbanised grid points of a high-resolution grid covering Italy; (ii) using these records to calculate corresponding grid point degree-days records; and (iii) averaging them to get national degree-days records representative of urban areas. The solar radiation record is obtained with the same averaging approach, with grid point solar radiation estimated from the corresponding daily temperature range. The model is based on deterministic components related to the weekly cyclical pattern of demand and to long-term demand changes and on weather-sensitive components related to cooling degree-days, heating degree-days and solar radiation. It establishes a strong contribution of cooling degree-days to the Italian electricity demand, with values peaking in summer months of the latest years up to 211 GWh day-1 (i.e. about 23 % of the corresponding average Italian electricity demand). This contribution shows a strong positive trend in the period considered here: the coefficient of the cooling degree-days term in the regression models increases from the first 2-year period (1990-1991) to the last one (2012-2013) by a factor 3.5, which is much greater than the increase of the Italian total electricity demand.

  17. [The surgical opportunity in metastatic lesions of renal-cell carcinoma after a response to adjuvant immunotherapy].

    PubMed

    Olivier, C; Carballido, J; Lao, A H; Bellido, D; Ramón y Cajal, S; Manzano, L; Ondina, L; Alvarez-Mon, M

    1995-03-01

    Surgical resection of primary lesions and single metastasis can be curative, but surgery, used as the only therapeutic option, is not unanimously accepted in patients with multiple metastasis and, apart from other considerations, there are no established clinical criteria to allow us to predict which patients will benefit from a metastectomy. This study evaluates four patients with advanced RCC. Three had multiple pulmonary metastasis at the time of diagnosis and one presented retroperitoneal mass at 36 months of follow-up. All patients were nephrectomized and received adjuvant immunotherapy with an association of IL-2 and 2b alpha-IFN subcutaneously, obtaining partial response of the disease after two treatment courses. Later, the patients underwent debulking surgery. Two patients are still alive and have no evidence of disease progression at 28 months and 8 months of follow-up. This data and that contrasted with other authors, suggests that surgical management would be a reasonable option in patients who have partially responded to immunotherapy, even though the selection of both candidates and surgical strategy should be considered on an individual basis.

  18. The controversy over H5N1 transmissibility research: an opportunity to define a practical response to a global threat.

    PubMed

    Fedson, David S; Opal, Steven M

    2013-05-01

    Since December 2011, influenza virologists and biosecurity experts have been engaged in a controversial debate over research on the transmissibility of H5N1 influenza viruses. Influenza virologists disagreed with the NSABB's recommendation not to publish experimental details of their findings, whereas biosecurity experts wanted the details to be withheld and future research restricted. The virologists initially declared a voluntary moratorium on their work, but later the NSABB allowed their articles to be published, and soon transmissibility research will resume. Throughout the debate, both sides have had understandable views, but both have overlooked the more important question of whether anything could be done if one of these experimentally derived viruses or a naturally occurring and highly virulent influenza virus should emerge and cause a global pandemic. This is a crucial question, because during the 2009 H1N1 influenza pandemic, more than 90% of the world's people had no access to timely supplies of affordable vaccines and antiviral agents. Observational studies suggest that inpatient statin treatment reduces mortality in patients with laboratory-confirmed seasonal influenza. Other immunomodulatory agents (glitazones, fibrates and AMPK agonists) improve survival in mice infected with influenza viruses. These agents are produced as inexpensive generics in developing countries. If they were shown to be effective, they could be used immediately to treat patients in any country with a basic health care system. For this reason alone, influenza virologists and biosecurity experts need to join with public health officials to develop an agenda for laboratory and clinical research on these agents. This is the only approach that could yield practical measures for a global response to the next influenza pandemic.

  19. Opportunity's Path

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This Long Term Planning graphic was created from a mosaic of navigation camera images overlain by a polar coordinate grid with the center point as Opportunity's original landing site. The blue dots represent the rover position at various locations.

    The red dots represent the center points of the target areas for the instruments on the rover mast (the panoramic camera and miniature thermal emission spectrometer). Opportunity visited Stone Mountain on Feb. 5. Stone Mountain was named after the southernmost point of the Appalachian Mountains outside of Atlanta, Ga. On Earth, Stone Mountain is the last big mountain before the Piedmont flatlands, and on Mars, Stone Mountain is at one end of Opportunity Ledge. El Capitan is a target of interest on Mars named after the second highest peak in Texas in Guadaloupe National Park, which is one of the most visited outcrops in the United States by geologists. It has been a training ground for students and professional geologists to understand what the layering means in relation to the formation of Earth, and scientists will study this prominent point of Opportunity Ledge to understand what the layering means on Mars.

    The yellow lines show the midpoint where the panoramic camera has swept and will sweep a 120-degree area from the three waypoints on the tour of the outcrop. Imagine a fan-shaped wedge from left to right of the yellow line.

    The white contour lines are one meter apart, and each drive has been roughly about 2-3 meters in length over the last few sols. The large white blocks are dropouts in the navigation camera data.

    Opportunity is driving along and taking a photographic panorama of the entire outcrop. Scientists will stitch together these images and use the new mosaic as a 'base map' to decide on geology targets of interest for a more detailed study of the outcrop using the instruments on the robotic arm. Once scientists choose their targets of interest, they plan to study the outcrop for roughly five to

  20. Opportunity fuels

    SciTech Connect

    Lutwen, R.C.

    1996-12-31

    The paper consists of viewgraphs from a conference presentation. A comparison is made of opportunity fuels, defined as fuels that can be converted to other forms of energy at lower cost than standard fossil fuels. Types of fuels for which some limited technical data is provided include petroleum coke, garbage, wood waste, and tires. Power plant economics and pollution concerns are listed for each fuel, and compared to coal and natural gas power plant costs. A detailed cost breakdown for different plant types is provided for use in base fuel pricing.

  1. Assessing Demand for Graduate and Professional Programs.

    ERIC Educational Resources Information Center

    Syverson, Peter D.

    1996-01-01

    Graduate education is entering an era of market segmentation, varying student demand, and changing requirements from employers, meaning graduate students will assess graduate opportunities differently and institutions will assess programs differently. The traditional view of graduate study as preparation for a research or teaching career and…

  2. Posing Cognitively Demanding Tasks to All Students

    ERIC Educational Resources Information Center

    Lambert, Rachel; Stylianou, Despina A.

    2013-01-01

    Cognitively demanding tasks (CDT) (Stein et al. 2000) are necessary for the development of students' mathematical reasoning skills. Research is unequivocal on the importance of giving students opportunities to engage in such tasks. Although current reform efforts call for mathematics learning for "all" students, learners who…

  3. The Demand for Higher Education in Belgium.

    ERIC Educational Resources Information Center

    Duchesne, I.; Nonneman, W.

    1998-01-01

    Investigates determinants behind the spectacular higher education enrollment growth in Belgium since 1953, using a demand model that integrates consumption and investment aspects and empirically tests time-series data specifications between 1953 and 1992. Income and foregone earnings are driving enrollments. Income, opportunity costs, and the wage…

  4. Burnout in Medical Residents: A Study Based on the Job Demands-Resources Model

    PubMed Central

    2014-01-01

    Purpose. Burnout is a prolonged response to chronic emotional and interpersonal stressors on the job. The purpose of our cross-sectional study was to estimate the burnout rates among medical residents in the largest Greek hospital in 2012 and identify factors associated with it, based on the job demands-resources model (JD-R). Method. Job demands were examined via a 17-item questionnaire assessing 4 characteristics (emotional demands, intellectual demands, workload, and home-work demands' interface) and job resources were measured via a 14-item questionnaire assessing 4 characteristics (autonomy, opportunities for professional development, support from colleagues, and supervisor's support). The Maslach Burnout Inventory (MBI) was used to measure burnout. Results. Of the 290 eligible residents, 90.7% responded. In total 14.4% of the residents were found to experience burnout. Multiple logistic regression analysis revealed that each increased point in the JD-R questionnaire score regarding home-work interface was associated with an increase in the odds of burnout by 25.5%. Conversely, each increased point for autonomy, opportunities in professional development, and each extra resident per specialist were associated with a decrease in the odds of burnout by 37.1%, 39.4%, and 59.0%, respectively. Conclusions. Burnout among medical residents is associated with home-work interface, autonomy, professional development, and resident to specialist ratio. PMID:25531003

  5. Strategic opportunities

    SciTech Connect

    Gottlieb, J.W.

    1994-09-01

    Despite statements of doom and gloom from numerous industry pundits, the potential for global hydropower development opportunities remains vast. Statistics demonstrating the potential for hydroelectric development in the United States alone are staggering. More than 80,000 dams exist in the United States, yet only 3 percent have been developed to tap their hydroelectric potential. There is currently about 70,800 MW of installed hydroelectric capacity, with more than 76,000 MW of undeveloped potential. It has been estimated that there are about 3,000 abandoned hydropower sites in the United States. Less than 200 of these sites have been redeveloped. The United States Department of Energy (DOE) has estimated redevelopment and rehabilitation of hydropower electric sites in the United States could add an additional 14,000 MW of potential.

  6. Surface-Water Techniques: On Demand Training Opportunities

    USGS Publications Warehouse

    ,

    2007-01-01

    The U.S. Geological Survey (USGS) has been collecting streamflow information since 1889 using nationally consistent methods. The need for such information was envisioned by John Wesley Powell as a key component for settlement of the arid western United States. Because of Powell?s vision the nation now has a rich streamflow data base that can be analyzed with confidence in both space and time. This means that data collected at a stream gaging station in Maine in 1903 can be compared to data collected in 2007 at the same gage in Maine or at a different gage in California. Such comparisons are becoming increasingly important as we work to assess climate variability and anthropogenic effects on streamflow. Training employees in proper and consistent techniques to collect and analyze streamflow data forms a cornerstone for maintaining the integrity of this rich data base.

  7. Caution: business opportunity ahead.

    PubMed

    Costello, M M

    1986-01-01

    Increasing competition in the market for health care services has led many providers to contemplate activities that would not have received consideration a decade ago. Entrepreneurial in nature, these endeavors require a form of business analysis with which many health care administrators are unfamiliar. Evaluation of health care business opportunities should include consideration of market perspective, relative difficulty of implementation and execution, likely response of competition, and unique aspects of the entrepreneurial personality when found in traditional health care organizations.

  8. Emergicenters. Opportunity or threat?

    PubMed

    Meyer, L C

    1983-01-01

    Political, social, and economic pressures on the healthcare industry are resulting in the development of new approaches to the delivery of quality health care to consumers. One of the newest responses to these change forces has been the development and proliferation of freestanding emergency centers. This article examines the underlying causes behind their development, describes the distinct services and strengths of the "emergicenter" concept, and shows how medical group practices can turn a potential competitive threat into an opportunity for future growth.

  9. Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA); interpretation of "federal public benefit"--HHS. Notice with comment period.

    PubMed

    1998-08-01

    This notice with comment period interprets the term "Federal public benefit" as used in Title IV of the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA), Pub. L. 104-193, and identifies the HHS programs that provide such benefits under this interpretation. According to section 401 if PRWORA, aliens who are not "qualified aliens" are not eligible for any "Federal public benefit," unless the "Federal public benefit" falls within a specified exception. A "Federal public benefit" includes "any grant, contract, loan, professional license, or commercial license" provided to an individual, and also "any retirement, welfare, health, disability, public or assisted housing, postsecondary education, food assistance, unemployment benefit, or any other similar benefit for which payments or assistance are provided to an individual, household, or family eligibility unit." Under section 432, providers of a non-exempt "Federal public benefit" must verify that a person applying for the benefit is a qualified alien and is eligible to receive the benefit. The HHS programs that provide "Federal public benefits" and are not otherwise excluded from the definition by the exceptions provided in section 401(b) are: Adoption Assistance Administration on Developmental Disabilities (ADD)-State Developmental Disabilities Councils (direct services only) ADD-Special Projects (direct services only) ADD-University Affiliated Programs (clinical disability assessment services only) Adult Programs/Payments to Territories Agency for Health Care Policy and Research Dissertation Grants Child Care and Development Fund Clinical Training Grant for Faculty Development in Alcohol & Drug Abuse Foster Care Health Profession Education and Training Assistance Independent Living Program Job Opportunities for Low Income Individuals (JOLI) Low Income Home Energy Assistance Program (LIHEAP) Medicare Medicaid (except assistance for an emergency medical condition) Mental Health Clinical

  10. An Analysis of the Demand for and Value of Outdoor Recreation in the United States.

    ERIC Educational Resources Information Center

    Bergstrom, John C.; Cordell, H. Ken

    1991-01-01

    Results of a study of demand equations for 37 outdoor recreational activities using a multicommunity, multisite travel cost model suggest that determinants of the demand for outdoor recreation include population, residence, income, age, price, quality, and recreational opportunity substitutes. (JD)

  11. Today's Principalship: New Dimensions/ New Demands

    ERIC Educational Resources Information Center

    Moser, Robert P.

    1974-01-01

    The fundamental responsibilities of the principalship are undergoing significant new demands in the '70s - demands challenging the principal to be a planner of futures, an allocator of resources, a stimulator of improvement, a coordinator of concerted effort, and an evaluator of process and product. (Editor)

  12. Teaching Aggregate Demand and Supply Models

    ERIC Educational Resources Information Center

    Wells, Graeme

    2010-01-01

    The author analyzes the inflation-targeting model that underlies recent textbook expositions of the aggregate demand-aggregate supply approach used in introductory courses in macroeconomics. He shows how numerical simulations of a model with inflation inertia can be used as a tool to help students understand adjustments in response to demand and…

  13. "Time enough! Or not enough time!" An oral history investigation of some British and Australian community nurses' responses to demands for "efficiency" in health care, 1960-2000.

    PubMed

    Hallett, Christine E; Madsen, Wendy; Pateman, Brian; Bradshaw, Julie

    2012-01-01

    Oral history methodology was used to investigate the perspectives of retired British district nurses and Australian domiciliary nurses who had practiced between 1960 and 2000. Interviews yielded insights into the dramatic changes in community nursing practice during the last four decades of the 20th century. Massive changes in health care and government-led drives for greater efficiency meant moving from practice governed by "experiential time" (in which perception of time depends on the quality of experience) to practice governed by "measured time" (in which experience itself is molded by the measurement of time). Nurses recognized that the quality of their working lives and their relationships with families had been altered by the social, cultural, and political changes, including the drive for professional recognition in nursing itself, soaring economic costs of health care and push for deinstitutionalization of care. Community nurses faced several dilemmas as they grappled with the demands for efficiency created by these changes.

  14. Demand Activated Manufacturing Architecture

    SciTech Connect

    Bender, T.R.; Zimmerman, J.J.

    2001-02-07

    Honeywell Federal Manufacturing & Technologies (FM&T) engineers John Zimmerman and Tom Bender directed separate projects within this CRADA. This Project Accomplishments Summary contains their reports independently. Zimmerman: In 1998 Honeywell FM&T partnered with the Demand Activated Manufacturing Architecture (DAMA) Cooperative Business Management Program to pilot the Supply Chain Integration Planning Prototype (SCIP). At the time, FM&T was developing an enterprise-wide supply chain management prototype called the Integrated Programmatic Scheduling System (IPSS) to improve the DOE's Nuclear Weapons Complex (NWC) supply chain. In the CRADA partnership, FM&T provided the IPSS technical and business infrastructure as a test bed for SCIP technology, and this would provide FM&T the opportunity to evaluate SCIP as the central schedule engine and decision support tool for IPSS. FM&T agreed to do the bulk of the work for piloting SCIP. In support of that aim, DAMA needed specific DOE Defense Programs opportunities to prove the value of its supply chain architecture and tools. In this partnership, FM&T teamed with Sandia National Labs (SNL), Division 6534, the other DAMA partner and developer of SCIP. FM&T tested SCIP in 1998 and 1999. Testing ended in 1999 when DAMA CRADA funding for FM&T ceased. Before entering the partnership, FM&T discovered that the DAMA SCIP technology had an array of applications in strategic, tactical, and operational planning and scheduling. At the time, FM&T planned to improve its supply chain performance by modernizing the NWC-wide planning and scheduling business processes and tools. The modernization took the form of a distributed client-server planning and scheduling system (IPSS) for planners and schedulers to use throughout the NWC on desktops through an off-the-shelf WEB browser. The planning and scheduling process within the NWC then, and today, is a labor-intensive paper-based method that plans and schedules more than 8,000 shipped parts

  15. The Demand for Tertiary Education--An Australian Study.

    ERIC Educational Resources Information Center

    Nicholls, Miles G.

    1984-01-01

    The demand for higher education in Australia is examined, and several hypotheses concerning the estimated effect of youth unemployment and the traditional human capital variables of the opportunity cost of education and expected future returns are evaluated using a previously developed demand model. (Author/MSE)

  16. 24 CFR 2004.24 - Processing demands or requests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PRODUCTION IN RESPONSE TO SUBPOENAS OR DEMANDS OF COURTS OR OTHER AUTHORITIES Requests for Testimony and... of the demand or request. The time for response will depend upon the scope of the request. (c) The... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Processing demands or...

  17. Effectiveness of an on-body lifting aid at reducing low back physical demands during an automotive assembly task: assessment of EMG response and user acceptability.

    PubMed

    Graham, Ryan B; Agnew, Michael J; Stevenson, Joan M

    2009-09-01

    The purpose of this study was to investigate the effectiveness and user acceptability of a Personal Lift-Assist Device (PLAD) at an automotive manufacturing facility, with operators who perform an on-line assembly process requiring forward bending and static holding. Surface EMG data were collected at six sites on the low back and abdomen, and an accelerometer was used to measure trunk inclination. Use of the PLAD significantly reduced the thoracic and lumbar erector spinae activity and EMG-predicted compression at the 10th, 50th, and 90th APDF percentile levels (p < or = 0.05), without significantly increasing rectus abdominus activity or trunk flexion. Similarly, ratings of perceived exertion were found to be significantly lower when wearing the PLAD (p = 0.006). Subjective opinions were positive, with 8/10 subjects indicating they would wear the device everyday. With slight changes, workers felt that the PLAD could be beneficial at reducing forces and discomfort in similar industrial or manual materials handling tasks that place excessive physical demands on the low back.

  18. An experimental study of the job demand-control model with measures of heart rate variability and salivary alpha-amylase: Evidence of increased stress responses to increased break autonomy.

    PubMed

    O'Donnell, Emma; Landolt, Kathleen; Hazi, Agnes; Dragano, Nico; Wright, Bradley J

    2015-01-01

    We assessed in an experimental design whether the stress response towards a work task was moderated by the autonomy to choose a break during the assigned time to complete the task. This setting is defined in accordance with the theoretical framework of the job-demand-control (JDC) model of work related stress. The findings from naturalistic investigations of a stress-buffering effect of autonomy (or 'buffer hypothesis') are equivocal and the experimental evidence is limited, especially with relation to physiological indices of stress. Our objective was to investigate if increased autonomy in a particular domain (break time control) was related with adaptive physiology using objective physiological markers of stress; heart rate variability (HRV) and salivary alpha amylase (sAA). We used a within-subject design and the 60 female participants were randomly assigned to an autonomy (free timing of break) and standard conditions (fixed timing of break) of a word processing task in a simulated office environment in a random order. Participants reported increased perceptions of autonomy, no difference in demand and performed worse in the task in the break-time autonomy versus the standard condition. The results revealed support for the manipulation of increased autonomy, but in the opposing direction. Increased autonomy was related with dysregulated physiological reactivity, synonymous with typical increased stress responses. Potentially, our findings may indicate that autonomy is not necessary a resource but could become an additional stressor when it adds additional complexity while the amount of work (demands) remains unchanged. Further, our findings underscore the need to collect objective physiological evidence of stress to supplement self-reported information. Self-report biases may partially explain the inconsistent findings with the buffer hypothesis. PMID:25290345

  19. Latin American demand

    SciTech Connect

    1994-12-01

    From Mexico to Argentina, independent power companies are finding great demand for their services in Latin America. But while legal and economic conditions are increasingly favorable, political and financial uncertainties make power development challenging.

  20. Impact of Energy Demands

    ERIC Educational Resources Information Center

    Cambel, Ali B.

    1970-01-01

    The types of pollutants associated with the process of power production are identified. A nine-point proposal is presented on the ways the increase in power demands might be achieved with the minimum threat to the environment. (PR)

  1. Supply and Demand

    MedlinePlus

    ... a good breastfeeding rhythm with your baby. In reality, the efficient supply-and-demand rhythm of normal ... is one reason it’s a good idea to alternate which breast you use to begin nursing. A ...

  2. Lesson on Demand. Lesson Plan.

    ERIC Educational Resources Information Center

    Weaver, Sue

    This lesson plan helps students understand the role consumer demand plays in the market system, i.e., how interactions in the marketplace help determine pricing. Students will participate in an activity that demonstrates the concepts of demand, demand schedule, demand curve, and the law of demand. The lesson plan provides student objectives;…

  3. Economic demand and essential value.

    PubMed

    Hursh, Steven R; Silberberg, Alan

    2008-01-01

    The strength of a rat's eating reflex correlates with hunger level when strength is measured by the response frequency that precedes eating (B. F. Skinner, 1932a, 1932b). On the basis of this finding, Skinner argued response frequency could index reflex strength. Subsequent work documented difficulties with this notion because responding was affected not only by the strengthening properties of the reinforcer but also by the rate-shaping effects of the schedule. This article obviates this problem by measuring strength via methods from behavioral economics. This approach uses demand curves to map how reinforcer consumption changes with changes in the "price" different ratio schedules impose. An exponential equation is used to model these demand curves. The value of this exponential's rate constant is used to scale the strength or essential value of a reinforcer, independent of the scalar dimensions of the reinforcer. Essential value determines the consumption level to be expected at particular prices and the response level that will occur to support that consumption. This approach permits comparing reinforcers that differ in kind, contributing toward the goal of scaling reinforcer value.

  4. Energy demand and population change.

    PubMed

    Allen, E L; Edmonds, J A

    1981-09-01

    During the post World War 2 years energy consumption has grown 136% while population grew about 51%; per capita consumption of energy expanded, therefore, about 60%. For a given population size, demographic changes mean an increase in energy needs; for instance the larger the group of retirement age people, the smaller their energy needs than are those for a younger group. Estimates indicate that by the year 2000 the energy impact will be toward higher per capita consumption with 60% of the population in the 19-61 age group of workers. Rising female labor force participation will increase the working group even more; it has also been found that income and energy grow at a proportional rate. The authors predict that gasoline consumption within the US will continue to rise with availability considering the larger number of female drivers and higher per capita incomes. The flow of illegal aliens (750,000/year) will have a major impact on income and will use greater amounts of energy than can be expected. A demographic change which will lower energy demands will be the slowdown of the rate of household formation caused by the falling number of young adults. The response of energy demand to price changes is small and slow but incomes play a larger role as does the number of personal automobiles and social changes affecting household formation. Households, commercial space, transportation, and industry are part of every demand analysis and population projections play a major role in determining these factors.

  5. Travel Demand Modeling

    SciTech Connect

    Southworth, Frank; Garrow, Dr. Laurie

    2011-01-01

    This chapter describes the principal types of both passenger and freight demand models in use today, providing a brief history of model development supported by references to a number of popular texts on the subject, and directing the reader to papers covering some of the more recent technical developments in the area. Over the past half century a variety of methods have been used to estimate and forecast travel demands, drawing concepts from economic/utility maximization theory, transportation system optimization and spatial interaction theory, using and often combining solution techniques as varied as Box-Jenkins methods, non-linear multivariate regression, non-linear mathematical programming, and agent-based microsimulation.

  6. Demand-oriented and demand-driven health care: the development of a typology.

    PubMed

    Rijckmans, Madeleine; Garretsen, Henk; van de Goor, Ien; Bongers, Inge

    2007-09-01

    In most European countries, there is an increasing demand for demand-oriented and demand-driven approaches in the development of health care policy and the organization of health care services. Both approaches, in which the main focus is on 'the demand', are seen as counterparts of the supply-oriented approach, that has 'the supply' as point of departure. However, there is much confusion about the definition of the concepts. To identify the different views, and to examine to what extent there is consensus in the Netherlands about the concepts of demand-orientation and demand-driven care, a Delphi study was done among 26 experts; scientists, health care insurance companies, health care suppliers, the government, independent advisory bodies and client interest groups. The study resulted in a typology. The similarities and differences between the two concepts were demonstrated in five dimensions; responsibility, control, need-determination, formal embedment of vision in organization and choice. Furthermore, the typology was used to identify existing types of services as being either demand-oriented or demand-driven services. The typology provides an understanding of the similarities and differences between the two concepts, and appears to be a useful tool in identifying services to the extent that they are demand oriented or demand driven. PMID:17727554

  7. Textbook Factor Demand Curves.

    ERIC Educational Resources Information Center

    Davis, Joe C.

    1994-01-01

    Maintains that teachers and textbook graphics follow the same basic pattern in illustrating changes in demand curves when product prices increase. Asserts that the use of computer graphics will enable teachers to be more precise in their graphic presentation of price elasticity. (CFR)

  8. Demanding Divestment from Sudan

    ERIC Educational Resources Information Center

    Asquith, Christina

    2006-01-01

    Bowing to student demands to "stop supporting genocide," the University of California regents voted earlier this year to divest millions of dollars from companies working in the war-torn African nation of Sudan, the first major public university in the nation to take such action. Since student protests on the subject began at Harvard University in…

  9. Driving Demand for Streaming

    ERIC Educational Resources Information Center

    Owen, Martin

    2006-01-01

    This paper describes the origin and work of an independent research and development facility whose role is to catalyse the development of broadband applications for education. The paper describes how a three pronged approach is helping content developers understand the opportunities and make use of good research and practice in learning to develop…

  10. Energy Problems Provide Job Opportunities.

    ERIC Educational Resources Information Center

    Moore, Allen B.

    In response to the problems created by a diminishing energy supply but an increasing energy demand, this second in a series of national reports studies the linkage of vocational education and energy. Through an examination of selected literature with reference to types of energy resources, the author identifies the emerging occupations related to…

  11. Using Utility Load Data to Estimate Demand for Space Cooling and Potential for Shiftable Loads

    SciTech Connect

    Denholm, P.; Ong, S.; Booten, C.

    2012-05-01

    This paper describes a simple method to estimate hourly cooling demand from historical utility load data. It compares total hourly demand to demand on cool days and compares these estimates of total cooling demand to previous regional and national estimates. Load profiles generated from this method may be used to estimate the potential for aggregated demand response or load shifting via cold storage.

  12. Barrier Immune Radio Communications for Demand Response

    SciTech Connect

    Rubinstein, Francis; Ghatikar, Girish; Granderson, Jessica; Haugen, Paul; Romero, Carlos; Watson, David

    2009-02-01

    Various wireless technologies were field-tested in a six-story laboratory building to identify wireless technologies that can scale for future DR applications through very low node density power consumption, and unit cost. Data analysis included analysis of the signal-to-noise ratio (SNR), packet loss, and link quality at varying power levels and node densities. The narrowband technologies performed well, penetrating the floors of the building with little loss and exhibiting better range than the wideband technology. 900 MHz provided full coverage at 1 watt and substantially complete coverage at 500 mW at the test site. 900 MHz was able to provide full coverage at 100 mW with only one additional relay transmitter, and was the highest-performing technology in the study. 2.4 GHz could not provide full coverage with only a single transmitter at the highest power level tested (63 mW). However, substantially complete coverage was provided at 2.4 GHz at 63 mW with the addition of one repeater node.

  13. Demand surge following earthquakes

    USGS Publications Warehouse

    Olsen, Anna H.

    2012-01-01

    Demand surge is understood to be a socio-economic phenomenon where repair costs for the same damage are higher after large- versus small-scale natural disasters. It has reportedly increased monetary losses by 20 to 50%. In previous work, a model for the increased costs of reconstruction labor and materials was developed for hurricanes in the Southeast United States. The model showed that labor cost increases, rather than the material component, drove the total repair cost increases, and this finding could be extended to earthquakes. A study of past large-scale disasters suggested that there may be additional explanations for demand surge. Two such explanations specific to earthquakes are the exclusion of insurance coverage for earthquake damage and possible concurrent causation of damage from an earthquake followed by fire or tsunami. Additional research into these aspects might provide a better explanation for increased monetary losses after large- vs. small-scale earthquakes.

  14. Demand for human allograft tissue in Canada.

    PubMed

    Lakey, Jonathan R T; Mirbolooki, Mohammadreza; Rogers, Christina; Mohr, Jim

    2007-01-01

    There is relatively little known about the demand for allograft tissues in Canada. The Canadian Council for Donation and Transplantation (CCDT) is a national advisory body that undertook a comprehensive "market survey" to estimate surgical demand for human allograft tissues in Canada. The report "Demand for Human Allograft Tissue in Canada" reflects survey results sent to 5 prominent User Groups. User Groups were identified as orthopaedic surgeons; neurosurgeons; corneal transplant surgeons; plastic surgeons, specifically those at Canadian Burn Units; and cardiac surgeons (adult and paediatric surgery). The demand for allograft grafts was determined and then extrapolated across the total User Group and then increases in allograft tissue use over the next 1-2 years across User Groups were predicted. The overall response rate for the survey was 21.4%. It varied from a low of 19.6% for the orthopaedic survey to a high of 40.5% for the corneal survey. The estimated current demand for allograft tissue in Canada ranges from a low of 34,442 grafts per year to a high of 62,098 grafts per year. The predicted increase in use of allograft tissue over the next 1-2 year period would suggest that annual demand could rise to somewhere in the range of 42,589-72,210 grafts. The highest rated preferences (98% and 94%) were for accredited and Canadian tissue banks, respectively. This study represents a key step in addressing the paucity of information concerning the demand for allograft tissue in Canada.

  15. 75 FR 52956 - Funding Opportunity

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... HUMAN SERVICES Administration on Aging Funding Opportunity Purpose of Notice: Availability of funding opportunity announcement. Funding Opportunity Title/Program Name: Older Americans Act (OAA), Title VI, Part A... funding opportunity. Funding Opportunity Number: Program Announcement No. is HHS-2011-...

  16. Applied Geophysics Opportunities in the Petroleum Industry

    NASA Astrophysics Data System (ADS)

    Olgaard, D. L.; Tikku, A.; Roberts, J. C.; Martinez, A.

    2012-12-01

    Meeting the increasing global demand for energy over the next several decades presents daunting challenges to engineers and scientists, including geoscientists of all disciplines. Many opportunities exist for geophysicists to find and produce oil and gas in a safe, environmentally responsible and affordable manner. Successful oil and gas exploration involves a 'Plates to Pores' approach that integrates multi-scale data from satellites, marine and land seismic and non-seismic field surveys, lab experiments, and even electron microscopy. The petroleum industry is at the forefront of using high performance computing to develop innovative methods to process and analyze large volumes of seismic data and perform realistic numerical modeling, such as finite element fluid flow and rock deformation simulations. Challenging and rewarding jobs in exploration, production and research exist for students with BS/BA, MS and PhD degrees. Geophysics students interested in careers in the petroleum industry should have a broad foundation in science, math and fundamental geosciences at the BS/BA level, as well as mastery of the scientific method, usually gained through thesis work at MS and PhD levels. Field geology or geophysics experience is also valuable. Other personal attributes typical for geoscientists to be successful in industry include a passion for solving complex geoscience problems, the flexibility to work on a variety of assignments throughout a career and skills such as teamwork, communication, integration and leadership. In this presentation we will give examples of research, exploration and production opportunities for geophysicists in petroleum companies and compare and contrast careers in academia vs. industry.

  17. Opportunity Cost: A Reexamination

    ERIC Educational Resources Information Center

    Parkin, Michael

    2016-01-01

    Is opportunity cost an ambiguous and arbitrary concept or a simple, straightforward, and fruitful one? This reexamination of opportunity cost addresses this question, and shows that opportunity cost is an ambiguous concept because "two" definitions are in widespread use. One of the definitions is indeed simple, fruitful, and one that…

  18. Analysis of recent projections of electric power demand

    SciTech Connect

    Hudson, Jr, D V

    1993-08-01

    This report reviews the changes and potential changes in the outlook for electric power demand since the publication of Review and Analysis of Electricity Supply Market Projections (B. Swezey, SERI/MR-360-3322, National Renewable Energy Laboratory). Forecasts of the following organizations were reviewed: DOE/Energy Information Administration, DOE/Policy Office, DRI/McGraw-Hill, North American Electric Reliability Council, and Gas Research Institute. Supply uncertainty was briefly reviewed to place the uncertainties of the demand outlook in perspective. Also discussed were opportunities for modular technologies, such as renewable energy technologies, to fill a potential gap in energy demand and supply.

  19. Further Evidence of Close Correspondence for Alcohol Demand Decision Making for Hypothetical and Incentivized Rewards

    PubMed Central

    Amlung, Michael; MacKillop, James

    2015-01-01

    Alcohol purchase tasks (APTs) are increasingly being used to assess behavioral economic demand for alcohol. Prior studies utilizing APTs have typically assessed demand for hypothetical outcomes, making the extent to which these hypothetical measures reflect preferences when actual rewards are at stake an important empirical question. This study examined alcohol demand across hypothetical and incentivized APTs. Nineteen male heavy drinkers completed two APTs—one for hypothetical alcohol and another in which one randomly-selected outcome was provided. Participants were given an opportunity to consume the alcohol associated with their choice on the incentivized APT during a self-administration period in a simulated bar environment. Results indicated generally close correspondence between APT versions, though participants were more sensitive to increases in price and tended to consume more at low prices on the incentivized version. Estimated consumption on the incentivized APT was highly correlated with the amount of alcohol consumed in the laboratory (r = .87, p < .001), suggesting that APT responses are valid indicators of actual drinking behavior. These results provide further evidence of congruence of demand-based decision-making when rewards are hypothetical vs. actually available. Implications for behavioral economic approaches to addictive behavior and directions for future research are discussed. PMID:25712039

  20. Further evidence of close correspondence for alcohol demand decision making for hypothetical and incentivized rewards.

    PubMed

    Amlung, Michael; MacKillop, James

    2015-04-01

    Alcohol purchase tasks (APTs) are increasingly being used to assess behavioral economic demand for alcohol. Prior studies utilizing APTs have typically assessed demand for hypothetical outcomes, making the extent to which these hypothetical measures reflect preferences when actual rewards are at stake an important empirical question. This study examined alcohol demand across hypothetical and incentivized APTs. Nineteen male heavy drinkers completed two APTs - one for hypothetical alcohol and another in which one randomly-selected outcome was provided. Participants were given an opportunity to consume the alcohol associated with their choice on the incentivized APT during a self-administration period in a simulated bar environment. Results indicated generally close correspondence between APT versions, though participants were more sensitive to increases in price and tended to consume more at low prices on the incentivized version. Estimated consumption on the incentivized APT was highly correlated with the amount of alcohol consumed in the laboratory (r=.87, p<.001), suggesting that APT responses are valid indicators of actual drinking behavior. These results provide further evidence of congruence of demand-based decision-making when rewards are hypothetical vs. actually available. Implications for behavioral economic approaches to addictive behavior and directions for future research are discussed.

  1. A window of opportunity study of potential tumor and soluble biomarkers of response to preoperative erlotinib in early stage non-small cell lung cancer

    PubMed Central

    Sacher, Adrian G.; Le, Lisa W.; Lara-Guerra, Humberto; Waddell, Thomas K.; Sakashita, Shingo; Chen, Zhuo; Kim, Lucia; Zhang, Tong; Kamel-Reid, Suzanne; Salvarrey, Alexandra; Darling, Gail; Yasufuku, Kazuhiro; Keshavjee, Shaf; de Perrot, Marc; Shepherd, Frances A.; Liu, Geoffrey; Tsao, Ming Sound; Leighl, Natasha B.

    2016-01-01

    Background: Erlotinib is highly active in EGFR mutant NSCLC, but may benefit some with wild-type tumors. We examined pre-operative erlotinib in early stage NSCLC to assess response and correlation with potential biomarkers. Results: Twenty-five patients were enrolled; 22 received erlotinib treatment and were evaluable (median follow-up 4.4 years). Histology was predominantly adenocarcinoma although 31% had squamous carcinoma. PET response was observed in 2 patients (9%), both with squamous carcinoma. Most (20/22) had stable disease (RECIST), with frequent minor radiographic regression and histologic findings of fibrosis/necrosis including in squamous histology. Only two had EGFR mutations identified, one with minor radiographic response and the other stable disease after 4 weeks of EGFR TKI. High pre-treatment serum levels of TGF-α correlated with primary resistance to erlotinib (p = 0.02), whereas high post-treatment soluble EGFR levels correlated with response (p = 0.03). EGFR, PTEN, cMET and AXL expression did not correlate with tumor response. Methods: Clinical stage IA–IIB NSCLC patients received erlotinib 150 mg daily for 4 weeks followed by resection. Tumor response was assessed using CT, PET and pathological response. Tumor genotype was established using Sequenom Mass ARRAY; EGFR, PTEN, cMET and AXL expression was assessed by immunohistochemistry, circulating markers of EGFR activation (TGF-α, amphiregulin, epiregulin, EGFR ECD) by ELISA and EGFR, MET copy number by FISH. Conclusions: Erlotinib appears to demonstrate activity in EGFR wild-type tumors including squamous carcinoma. Further research is needed to characterize those wild-type patients that may benefit from EGFR TKI and predictive biomarkers including TGF-α, EGFR copy and others. PMID:27028852

  2. Changes in respiratory mitochondrial machinery and cytochrome and alternative pathway activities in response to energy demand underlie the acclimation of respiration to elevated CO2 in the invasive Opuntia ficus-indica.

    PubMed

    Gomez-Casanovas, Nuria; Blanc-Betes, Elena; Gonzalez-Meler, Miquel A; Azcon-Bieto, Joaquim

    2007-09-01

    Studies on long-term effects of plants grown at elevated CO(2) are scarce and mechanisms of such responses are largely unknown. To gain mechanistic understanding on respiratory acclimation to elevated CO(2), the Crassulacean acid metabolism Mediterranean invasive Opuntia ficus-indica Miller was grown at various CO(2) concentrations. Respiration rates, maximum activity of cytochrome c oxidase, and active mitochondrial number consistently decreased in plants grown at elevated CO(2) during the 9 months of the study when compared to ambient plants. Plant growth at elevated CO(2) also reduced cytochrome pathway activity, but increased the activity of the alternative pathway. Despite all these effects seen in plants grown at high CO(2), the specific oxygen uptake rate per unit of active mitochondria was the same for plants grown at ambient and elevated CO(2). Although decreases in photorespiration activity have been pointed out as a factor contributing to the long-term acclimation of plant respiration to growth at elevated CO(2), the homeostatic maintenance of specific respiratory rate per unit of mitochondria in response to high CO(2) suggests that photorespiratory activity may play a small role on the long-term acclimation of respiration to elevated CO(2). However, despite growth enhancement and as a result of the inhibition in cytochrome pathway activity by elevated CO(2), total mitochondrial ATP production was decreased by plant growth at elevated CO(2) when compared to ambient-grown plants. Because plant growth at elevated CO(2) increased biomass but reduced respiratory machinery, activity, and ATP yields while maintaining O(2) consumption rates per unit of mitochondria, we suggest that acclimation to elevated CO(2) results from physiological adjustment of respiration to tissue ATP demand, which may not be entirely driven by nitrogen metabolism as previously suggested.

  3. Environmental preservation demand: Altruistic, bequest, and intrinsic motives

    SciTech Connect

    Whitehead, J.C.; Thompson, C.Y. )

    1993-01-01

    When the demand for environmental preservation is not explicitly revealed in markets, motivating attitudes toward environmental preservation become important. A survey approach allows revelation and measurement of demand for environmental preservation. Indices which measure the altruistic, bequest, intrinsic, and option to use motives and other attitudes are utilized as determinants in a model that measures the demand for environmental preservation. Demand is more likely with greater preservation motives. Preservation demand also depends on individual preferences for economic development, perceptions of affordability and responsibility for preservation of the wetlands. 17 refs., 3 tabs.

  4. Fax-on-Demand: An Introduction.

    ERIC Educational Resources Information Center

    Lachman, Christine E.; And Others

    1991-01-01

    Fax-on-demand is a response application that allows callers to use touchtone telephones to access databases and other information. The information is then delivered to the caller's fax machine. Ten sidebars describe a variety of specific services. (11 references) (DB)

  5. Growing collateral arteries on demand.

    PubMed

    Oh, Charles C; Klein, Jason D; Migrino, Raymond Q; Thornburg, Kent L

    2011-09-01

    Recent studies have significantly advanced our understanding of arteriogenesis, raising hope that therapies to increase collateral arterial formation may become important new tools in the treatment of ischemic disease. The most important initiating trigger for arteriogenesis is the marked increase in shear stress which is sensed by the endothelium and leads to characteristic changes. Intracellularly, it was shown that platelet endothelial cell adhesion molecule (PECAM-1) becomes tyrosine-phosphorylated in response to increased shear stress, suggesting a role as a possible mechanoreceptor for dynamic and continual monitoring of shear stress. The signal generated by PECAM-1 leads to the activation of the Rho pathway among others. More than 40 genes have been shown to have a shear stress responsive element. The Rho pathway is activated early and appears to be essential to the arteriogenic response as inhibiting it abolished the effect of fluid shear stress. Overexpression of a Rho pathway member, Actin-binding Rho protein (Abra), led to a 60% increase in collateral perfusion over simple femoral artery occlusion. A patent for the Abra gene has been filed recently. It may be a harbinger of a future where collateral arteries grown on demand may become an effective treatment for ischemic vascular disease. PMID:21861827

  6. The imperfect price-reversibility of world oil demand

    SciTech Connect

    Gately, D.

    1993-12-31

    This paper examines the price-reversibility of world oil demand, using price-decomposition methods employed previously on other energy demand data. We conclude that the reductions in world oil demand following the oil price increases of the 1970s will not be completely reversed by the price cuts of the 1980s. The response to price cuts in the 1980s is perhaps only one-fifth that for price increases in the 1970s. This has dramatic implications for projections of oil demand, especially under low-price assumptions. We also consider the effect on demand of a price recovery (sub-maximum increase) in the 1990s - due either to OPEC or to a carbon tax-specifically whether the effects would be as large as for the price increases of the 1970s or only as large as the smaller demand reversals of the 1980s. On this the results are uncertain, but a tentative conclusion is that the response to a price recovery would lie midway between the small response to price cuts and the larger response to increases in the maximum historical price. Finally, we demonstrate two implications of wrongly assuming that demand is perfectly price-reversible. First, such an assumption will grossly overestimate the demand response to price declines of the 1980s. Secondly, and somewhat surprisingly, it causes an underestimate of the effect of income growth on future demand. 21 refs., 11 figs., 1 tab.

  7. Tuition Fees and the Demand for University Places

    ERIC Educational Resources Information Center

    Neill, Christine

    2009-01-01

    Estimating the effect of tuition fee increases on demand for a university education is complicated by the potential endogeneity of tuition fees. The relative homogeneity of university tuition fees within Canadian provinces and the role of provincial governments in university funding and policies, provides an opportunity to use changes in the…

  8. Elucidating the molecular responses of apple rootstock resistant to ARD pathogens: Challenges and opportunities for development of genomics-assisted breeding tools

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Apple Replant Disease (ARD) is one of the major limitations to the establishment of an economically viable orchard on replant sites due to the buildup and long-term survival of pathogen inoculum. Infection by several soilborne necrotrophic fungi and oomycetes is primarily responsible for ARD and res...

  9. New demands on desalter operations

    SciTech Connect

    Witzig, W.L.

    1987-01-01

    Increased demands for improved desalter performance focus primarily on salt content and BS and W (basic sediment and water) content of the desalted crude. Recent demands target removal of other inorganic impurities which deactivate catalysts and contaminate finish products. The specific demand or performance need is usually apparent and easily quantified. This paper focuses on methods to achieve these demands through process optimization, chemical treatment, and employing an integrated process approach to desalting.

  10. Elucidating the molecular responses of apple rootstock resistant to ARD pathogens: challenges and opportunities for development of genomics-assisted breeding tools

    PubMed Central

    Zhu, Yanmin; Fazio, Gennaro; Mazzola, Mark

    2014-01-01

    Apple replant disease (ARD) is a major limitation to the establishment of economically viable orchards on replant sites due to the buildup and long-term survival of pathogen inoculum. Several soilborne necrotrophic fungi and oomycetes are primarily responsible for ARD, and symptoms range from serious inhibition of growth to the death of young trees. Chemical fumigation has been the primary method used for control of ARD, and manipulating soil microbial ecology to reduce pathogen density and aggressiveness is being investigated. To date, innate resistance of apple rootstocks as a means to control this disease has not been carefully explored, partly due to the complex etiology and the difficulty in phenotyping the disease resistance. Molecular defense responses of plant roots to soilborne necrotrophic pathogens are largely elusive, although considerable progress has been achieved using foliar disease systems. Plant defense responses to necrotrophic pathogens consist of several interacting modules and operate as a network. Upon pathogen detection by plants, cellular signals such as the oscillation of Ca2+ concentration, reactive oxygen species (ROS) burst and protein kinase activity, lead to plant hormone biosynthesis and signaling. Jasmonic acid (JA) and ethylene (ET) are known to be fundamental to the induction and regulation of defense mechanisms toward invading necrotrophic pathogens. Complicated hormone crosstalk modulates the fine-tuning of transcriptional reprogramming and metabolic redirection, resulting in production of antimicrobial metabolites, enzyme inhibitors and cell wall refortification to restrict further pathogenesis. Transcriptome profiling of apple roots in response to inoculation with Pythium ultimum demonstrated that there is a high degree of conservation regarding the molecular framework of defense responses compared with those observed with foliar tissues. It is conceivable that the timing and intensity of genotype-specific defense responses

  11. Physical demands in worklife.

    PubMed

    Astrand, I

    1988-01-01

    Industrial occupations which are physically strenuous in the traditional sense of the word have decreased in number. They have partly been replaced by "light," repetitive, monotonous work tasks performed in a sitting position. The number of heavy work tasks within the service sector has increased. Specialization has been intensified. The individual's capacity for strenuous work is still of importance to successful work performance. Many studies show that an optional choice of work pace in physically demanding occupational work results in an adaptation of pace or intensity until the worker is utilizing 40-50% of her or his capacity. When the work rate is constrained, the relative strain of the individual varies inversely with the physical work capacity. The frequency of musculoskeletal disorders has concurrently increased with the implementation of industrial mechanization. New, wise, ergonomic moves are needed to stop this development.

  12. Job Demand and Job Resources related to the turnover intention of public health nurses: An analysis using a Job Demands-Resources model.

    PubMed

    Iguchi, Aya

    2016-01-01

    Objectives The purpose of this study was to investigate the job demands and job resources of public health nurses based on the Job Demands-Resources (JD-R) model, and to build a model that can estimate turnover intention based on job demands and job resources.Method By adding 12 items to the existing questionnaire, the author created a questionnaire consisting of 10 factors and 167 items, and used statistical analysis to examine job demands and job resources in relation to turnover intention.Results Out of 2,668 questionnaires sent, 1993 (72.5%) were returned. Considering sex-based differences in occupational stress, I analyzed women's answers in 1766 (66.2%) mails among the 1798 valid responses. The average age of respondents was 41.0±9.8 years, and the mean service duration was 17.0±10.0 years. For public health nurses, there was a turnover intention of 9.2%. The "job demands" section consisted of 29 items and 10 factors, while the "job resources" section consisted of 54 items and 22 factors. The result of examining the structure of job demands and job resources, leading to turnover intention was supported by the JD-R model. Turnover intention was strong and the Mental Component Summary (MCS) is low in those who had many job demands and few job resources (experiencing 'burn-out'). Enhancement of work engagement and turnover intention was weak in those who had many job resources. This explained approximately 60% of the dispersion to "burn-out", and approximately 40% to "work engagement", with four factors: work suitability, work significance, positive work self-balance, and growth opportunity of job resources.Conclusion This study revealed that turnover intention is strong in those who are burned out because of many job demands. Enhancement of work engagement and turnover intention is weak in those with many job resources. This suggests that suitable staffing and organized efforts to raise awareness of job significance are effective in reducing

  13. Job Demand and Job Resources related to the turnover intention of public health nurses: An analysis using a Job Demands-Resources model.

    PubMed

    Iguchi, Aya

    2016-01-01

    Objectives The purpose of this study was to investigate the job demands and job resources of public health nurses based on the Job Demands-Resources (JD-R) model, and to build a model that can estimate turnover intention based on job demands and job resources.Method By adding 12 items to the existing questionnaire, the author created a questionnaire consisting of 10 factors and 167 items, and used statistical analysis to examine job demands and job resources in relation to turnover intention.Results Out of 2,668 questionnaires sent, 1993 (72.5%) were returned. Considering sex-based differences in occupational stress, I analyzed women's answers in 1766 (66.2%) mails among the 1798 valid responses. The average age of respondents was 41.0±9.8 years, and the mean service duration was 17.0±10.0 years. For public health nurses, there was a turnover intention of 9.2%. The "job demands" section consisted of 29 items and 10 factors, while the "job resources" section consisted of 54 items and 22 factors. The result of examining the structure of job demands and job resources, leading to turnover intention was supported by the JD-R model. Turnover intention was strong and the Mental Component Summary (MCS) is low in those who had many job demands and few job resources (experiencing 'burn-out'). Enhancement of work engagement and turnover intention was weak in those who had many job resources. This explained approximately 60% of the dispersion to "burn-out", and approximately 40% to "work engagement", with four factors: work suitability, work significance, positive work self-balance, and growth opportunity of job resources.Conclusion This study revealed that turnover intention is strong in those who are burned out because of many job demands. Enhancement of work engagement and turnover intention is weak in those with many job resources. This suggests that suitable staffing and organized efforts to raise awareness of job significance are effective in reducing

  14. Crowdsourcing healthcare costs: Opportunities and challenges for patient centered price transparency.

    PubMed

    Meisel, Zachary F; VonHoltz, Lauren A Houdek; Merchant, Raina M

    2016-03-01

    Efforts to improve health care price transparency have garnered significant attention from patients, policy makers, and health insurers. In response to increasing consumer demand, state governments, insurance plans, and health care providers are reporting health care prices. However, such data often do not provide consumers with the most salient information: their own actual out-of-pocket cost for medical care. Although untested, crowdsourcing, a mechanism for the public to help answer complex questions, represents a potential solution to the problem of opaque hospital costs. This article explores, the challenges and potential opportunities for crowdsourcing out-of-pocket costs for healthcare consumers. PMID:27001090

  15. [Opportunity and challenge on molecular epidemiology].

    PubMed

    Duan, G C; Chen, S Y

    2016-08-10

    Molecular epidemiology, a branch of epidemiology, combines the theories and methods, both in epidemiology and molecular biology. Molecular epidemiology mainly focuses on biological markers, describing the distribution, occurrence, development and prognosis of diseases at the molecular level. The completion of Human Genome Project and rapid development of Precision Medicine and Big Data not only offer the new development opportunities but also bring about a higher demand and new challenge for molecular epidemiology. PMID:27539332

  16. NASA's Flight Opportunities Program

    NASA Video Gallery

    NASA's Flight Opportunities Program is facilitating low-cost access to suborbital space, where researchers can test technologies using commercially developed vehicles. Suborbital flights can quickl...

  17. Haemophilia Experiences, Results and Opportunities (HERO) study: treatment-related characteristics of the population.

    PubMed

    Nugent, D; Kalnins, W; Querol, F; Gregory, M; Pilgaard, T; Cooper, D L; Iorio, A

    2015-01-01

    The HERO (Haemophilia Experiences, Results and Opportunities) quantitative surveys collected information on characteristics and perceptions of adult persons with haemophilia (PWH) and parents of children with haemophilia. The aim of this article is to describe the perceptions of PWH and parents on psychosocial aspects related to treatment. Two online surveys (one for PWH, one for parents) were conducted in 10 countries. Among 675 PWH respondents, 77% reported having responsibility for their own care; 72% of 561 parent respondents had the main responsibility for their son. PWH were most commonly treated on demand (45% of 648 adults using factor concentrate), with 32% on regular prophylaxis and 23% treated on demand with short-term prophylaxis (e.g. for sports/physiotherapy). Children were most often treated with prophylaxis (65% of 549 children using factor concentrate), with 26% treated on demand and 8% treated on demand with short-term prophylaxis. Factor was generally used as instructed at home. Some respondents (41% PWH; 30% parents) had difficulties/concerns with factor availability/affordability. PWH reported more bleeds in the last 12 months than parents reporting their son's bleeds (mean 17.8 vs. 8.7). Both PWH and parents generally perceived that overall, their (their son's) haemophilia was well controlled. Results differed by country. The HERO study captured new, patient-based data regarding many facets of life relevant to PWH, including treatment. The information conveyed in this article largely represents new insights regarding perceptions of treatment and provides initial benchmark statistics for further research.

  18. 36 CFR 1251.2 - To what demands does this part apply?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to demands to NARA employees for factual, opinion, or expert testimony relating to agency information... records or testimony in matters before the Equal Employment Opportunity Commission or the Merit...

  19. 36 CFR 1251.2 - To what demands does this part apply?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... to demands to NARA employees for factual, opinion, or expert testimony relating to agency information... records or testimony in matters before the Equal Employment Opportunity Commission or the Merit...

  20. 36 CFR 1251.2 - To what demands does this part apply?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... to demands to NARA employees for factual, opinion, or expert testimony relating to agency information... records or testimony in matters before the Equal Employment Opportunity Commission or the Merit...

  1. Demand access communications for TDRSS users

    NASA Technical Reports Server (NTRS)

    Zillig, David; Weinberg, Aaron; Mcomber, Robert

    1994-01-01

    The Tracking and Data Relay Satellite System (TDRSS) has long been used to provide reliable low and high-data rate relay services between user spacecraft in Earth orbit and the ground. To date, these TDRSS services have been implemented via prior scheduling based upon estimates of user needs and mission event timelines. While this approach may be necessary for large users that require greater amounts of TDRSS resources, TDRSS can potentially offer the planned community of smaller science missions (e.g., the small explorer missions), and other emerging users, the unique opportunity for services on demand. In particular, innovative application of the existing TDRSS Multiple Access (MA) subsystem, with its phased array antenna, could be used to implement true demand access services without modification to either the TDRSS satellites or the user transponder, thereby introducing operational and performance benefits to both the user community and the Space Network. In this paper, candidate implementations of demand access service via the TDRSS MA subsystem are examined in detail. Both forward and return link services are addressed and a combination of qualitative and quantitative assessments are provided. The paper also identifies further areas for investigation in this ongoing activity that is being conducted by GSFC/Code 531 under the NASA Code O Advanced Systems Program.

  2. 28 CFR 16.27 - Procedure in the event a department decision concerning a demand is not made prior to the time a...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... decision concerning a demand is not made prior to the time a response to the demand is required. 16.27... department decision concerning a demand is not made prior to the time a response to the demand is required. If response to a demand is required before the instructions from the appropriate Department...

  3. Probabilistic seismic demand analysis of nonlinear structures

    NASA Astrophysics Data System (ADS)

    Shome, Nilesh

    Recent earthquakes in California have initiated improvement in current design philosophy and at present the civil engineering community is working towards development of performance-based earthquake engineering of structures. The objective of this study is to develop efficient, but accurate procedures for probabilistic analysis of nonlinear seismic behavior of structures. The proposed procedures help the near-term development of seismic-building assessments which require an estimation of seismic demand at a given intensity level. We also develop procedures to estimate the probability of exceedance of any specified nonlinear response level due to future ground motions at a specific site. This is referred as Probabilistic Seismic Demand Analysis (PSDA). The latter procedure prepares the way for the next stage development of seismic assessment that consider the uncertainties in nonlinear response and capacity. The proposed procedures require structure-specific nonlinear analyses for a relatively small set of recorded accelerograms and (site-specific or USGS-map-like) seismic hazard analyses. We have addressed some of the important issues of nonlinear seismic demand analysis, which are selection of records for structural analysis, the number of records to be used, scaling of records, etc. Initially these issues are studied through nonlinear analysis of structures for a number of magnitude-distance bins of records. Subsequently we introduce regression analysis of response results against spectral acceleration, magnitude, duration, etc., which helps to resolve these issues more systematically. We illustrate the demand-hazard calculations through two major example problems: a 5story and a 20-story SMRF building. Several simple, but quite accurate closed-form solutions have also been proposed to expedite the demand-hazard calculations. We find that vector-valued (e.g., 2-D) PSDA estimates demand hazard more accurately. This procedure, however, requires information about 2

  4. USGS Map-on-Demand Printing

    USGS Publications Warehouse

    ,

    1999-01-01

    Currently, the U.S. Geological Survey (USGS) uses conventional lithographic printing techniques to produce paper copies of most of its mapping products. This practice is not economical for those products that are in low demand. With the advent of newer technologies, high-speed, large-format printers have been coupled with innovative computer software to turn digital map data into a printed map. It is now possible to store and retrieve data from vast geospatial data bases and print a map on an as-needed basis; that is, print on demand, thereby eliminating the need to warehouse an inventory of paper maps for which there is low demand. Using print-on-demand technology, the USGS is implementing map-on-demand (MOD) printing for certain infrequently requested maps. By providing MOD, the USGS can offer an alternative to traditional, large-volume printing and can improve its responsiveness to customers by giving them greater access to USGS scientific data in a format that otherwise might not be available.

  5. 10 CFR 202.23 - Procedure in the event of a demand for production or disclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INFORMATION Production or Disclosure in Response to Subpoenas or Demands of Courts or Other Authorities § 202.23 Procedure in the event of a demand for production or disclosure. (a) Whenever a demand is made... 10 Energy 3 2010-01-01 2010-01-01 false Procedure in the event of a demand for production...

  6. 10 CFR 9.202 - Procedure in the event of a demand for production or disclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... in Response to Subpoenas or Demands of Courts or Other Authorities § 9.202 Procedure in the event of a demand for production or disclosure. (a) Prior to or simultaneous with a demand upon an employee... 10 Energy 1 2010-01-01 2010-01-01 false Procedure in the event of a demand for production...

  7. 24 CFR 15.203 - Making a demand for production of material or provision of testimony.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Provision of Testimony in Response to Demands in Legal Proceedings Among Private Litigants § 15.203 Making a demand for production of material or provision of testimony. (a) Any demand made to the Department or an... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Making a demand for production...

  8. An Opportunity to Rise

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image shows the Mars Exploration Rover Opportunity's wheels in their stowed configuration. As of 9:00 a.m. January 28, 2004, the rover had deployed its wheels and completed the first half of the stand-up process. This image was taken at Opportunity's landing site, Meridiani Planum, by the hazard-identification camera.

  9. RECREATIONAL AND CULTURAL OPPORTUNITIES.

    ERIC Educational Resources Information Center

    BELDON, RENA

    RECREATIONAL AND CULTURAL OPPORTUNITIES FOR MOST RURAL YOUTH ARE CENTERED AROUND SCHOOLS, BUT WITH INCREASING EMPHASIS ON ACADEMIC SUBJECTS THE STUDENTS ARE BEING DEPRIVED OF OPPORTUNITIES TO PARTICIPATE IN CERTAIN ACTIVITIES FOR ENJOYMENT ONLY. SUGGESTIONS INCLUDE TAKING THE PERFORMING ARTS TO THE RURAL AREAS, PLANNING ART FESTIVALS THAT WOULD…

  10. RECREATION AND CULTURAL OPPORTUNITIES.

    ERIC Educational Resources Information Center

    HARVEY, ELLEN E.

    RECREATIONAL ACTIVITIES AND OPPORTUNITIES SEEM TO BE CLOSELY INVOLVED WITH THE FEDERAL GOVERNMENT, BOTH IN FINANCIAL SUPPORT AND IN THE ACTUAL OPPORTUNITIES POSSIBLE. CONSEQUENTLY, THE TIME IS RIPE FOR THE ORIGIN AND/OR DEVELOPMENT OF ONE OR MORE NEW AGENCIES WITH THE INTERESTS AND NEEDS OF MODERN YOUTH AS THE LEVER FOR THEIR BEGINNING. TO…

  11. Mesenchymal stromal cell therapy in liver disease: opportunities and lessons to be learnt?

    PubMed Central

    Owen, Andrew

    2015-01-01

    End-stage liver disease is responsible for 30,000 deaths per year in the United States alone, and it is continuing to increase every year. With liver transplantation the only curative treatment currently available, new therapies are in great demand. Mesenchymal stem cells (MSC) offer an opportunity to both treat liver inflammatory damage, as well as reverse some of the changes that occur following chronic liver injury. With the ability to regulate both the innate and adaptive immune system, as well as both inhibit and promote apoptosis of effector inflammatory cells, there are numerous therapeutic opportunities for MSC in acute and chronic liver disease. This article critically appraises the potential therapeutic roles of MSC in liver disease, as well as the barriers to their adoption into clinical practice. PMID:26316587

  12. Mesenchymal stromal cell therapy in liver disease: opportunities and lessons to be learnt?

    PubMed

    Owen, Andrew; Newsome, Philip N

    2015-11-15

    End-stage liver disease is responsible for 30,000 deaths per year in the United States alone, and it is continuing to increase every year. With liver transplantation the only curative treatment currently available, new therapies are in great demand. Mesenchymal stem cells (MSC) offer an opportunity to both treat liver inflammatory damage, as well as reverse some of the changes that occur following chronic liver injury. With the ability to regulate both the innate and adaptive immune system, as well as both inhibit and promote apoptosis of effector inflammatory cells, there are numerous therapeutic opportunities for MSC in acute and chronic liver disease. This article critically appraises the potential therapeutic roles of MSC in liver disease, as well as the barriers to their adoption into clinical practice. PMID:26316587

  13. Effects of Demand Complexity on Echolalia in Students with Autism

    ERIC Educational Resources Information Center

    Edelstein, Matthew Lawrence

    2015-01-01

    Echolalia is a linguistic phenomenon common in individuals with Autism Spectrum Disorder. This study examined the relationship between demand complexity and immediate echolalia in 4 students with an autism diagnosis in a university-based academic setting. Mastered and novel antecedent verbal demands that required an intraverbal response were…

  14. Higher Education and the Demand for Social Action.

    ERIC Educational Resources Information Center

    Campbell, Roald F.

    Universities are beset with many demands to join in social action. Some of these demands run counter to the traditional purposes of the university: the production and transmission of knowledge. Universities' responses range from isolation or withdrawal as recently espoused by Barzun in The American University to a call for direct social action…

  15. Disaster research: a nursing opportunity.

    PubMed

    Giarratano, Gloria; Savage, Jane; Barcelona-deMendoza, Veronica; Harville, Emily W

    2014-09-01

    Nurses working or living near a community disaster have the opportunity to study health-related consequences to disaster or disaster recovery. In such a situation, the researchers need to deal with the conceptual and methodological issues unique to postdisaster research and know what resources are available to guide them, even if they have no specialized training or previous experience in disaster research. The purpose of this article is to review issues and challenges associated with conducting postdisaster research and encourage nurses to seek resources and seize opportunities to conduct research should the situation arise. Current disaster studies and the authors' personal experiences conducting maternal-child research in post-Katrina New Orleans (2005-2013) provide real-life examples of how health professionals and nurses faced the challenges of doing postdisaster research. After catastrophic events, nurses need to step forward to conduct disaster research that informs and improves future disaster planning and healthcare responses.

  16. An integrated communications demand model

    NASA Astrophysics Data System (ADS)

    Doubleday, C. F.

    1980-11-01

    A computer model of communications demand is being developed to permit dynamic simulations of the long-term evolution of demand for communications media in the U.K. to be made under alternative assumptions about social, economic and technological trends in British Telecom's business environment. The context and objectives of the project and the potential uses of the model are reviewed, and four key concepts in the demand for communications media, around which the model is being structured are discussed: (1) the generation of communications demand; (2) substitution between media; (3) technological convergence; and (4) competition. Two outline perspectives on the model itself are given.

  17. Exploring opportunities to project a "responsible man" image: gatekeepers views of young men's sexual and reproductive health needs in Uttaranchal, India.

    PubMed

    Khan, M E; Mishra, Anurag; Morankar, Sudhakar

    Increase in extramarital sex among youths, gender-based violence, lack of contraceptive knowledge among newly married couples and lack of knowledge of protection against diseases like STIs/HIV are the information and service needs of young people that need to be addressed urgently in order to make them future knowledgeable, responsible, and non-violent partners. In addressing these needs the gatekeepers, including parents, formal and informal community leaders and teachers, play a critical role, by facilitating/hindering access to appropriate and correct information about sexual and reproductive health to young people. The study was conducted in a district of Uttaranchal, India. The specific objective was to understand the social context and gatekeepers' views on family planning and sexual and reproductive health needs of young men. Thirty-two in-depth interviews and four focus group discussions were conducted with parents, formal and informal community leaders, teachers, and selected development officials. The findings indicate that gatekeepers are worried about rapid changes in the aspiration, expectation, and behavior of young men. Most of them were seriously concerned about the increasing drinking habit, use of drugs, and changing values of sexuality leading to various risk behaviors among young men. They felt that many of these changes are consequences of wider societal changes, rising aspirations, explosion of electronic media, and globalization of a new youth culture where extramarital sex, alcohol consumption, and violence are expressions of different facets of masculinity and symbols of the affluent class. Overall, there was a feeling that TV/films and their peers now influence more the socialization of young people and parents are losing control in guidance and mentoring of their children. PMID:18644762

  18. Exploring opportunities to project a "responsible man" image: gatekeepers views of young men's sexual and reproductive health needs in Uttaranchal, India.

    PubMed

    Khan, M E; Mishra, Anurag; Morankar, Sudhakar

    Increase in extramarital sex among youths, gender-based violence, lack of contraceptive knowledge among newly married couples and lack of knowledge of protection against diseases like STIs/HIV are the information and service needs of young people that need to be addressed urgently in order to make them future knowledgeable, responsible, and non-violent partners. In addressing these needs the gatekeepers, including parents, formal and informal community leaders and teachers, play a critical role, by facilitating/hindering access to appropriate and correct information about sexual and reproductive health to young people. The study was conducted in a district of Uttaranchal, India. The specific objective was to understand the social context and gatekeepers' views on family planning and sexual and reproductive health needs of young men. Thirty-two in-depth interviews and four focus group discussions were conducted with parents, formal and informal community leaders, teachers, and selected development officials. The findings indicate that gatekeepers are worried about rapid changes in the aspiration, expectation, and behavior of young men. Most of them were seriously concerned about the increasing drinking habit, use of drugs, and changing values of sexuality leading to various risk behaviors among young men. They felt that many of these changes are consequences of wider societal changes, rising aspirations, explosion of electronic media, and globalization of a new youth culture where extramarital sex, alcohol consumption, and violence are expressions of different facets of masculinity and symbols of the affluent class. Overall, there was a feeling that TV/films and their peers now influence more the socialization of young people and parents are losing control in guidance and mentoring of their children.

  19. Enhancing scope of practice for the second level nurse: a change process to meet growing demand for rural health services.

    PubMed

    Nankervis, Katrina; Kenny, Amanda; Bish, Melanie

    2008-06-01

    This article reports on Australian research, funded by the Victorian Department of Human Services Nurse Policy Branch and conducted in two rural Victorian health services. Predicted workforce shortages in the health professions and accompanying growth in demand for services have set the scene for exploring new ways of working. Focused on Victoria's second level nurse, the division two registered or enrolled nurse, this research explored opportunities to enhance scope of practice as one mechanism to meet anticipated workforce demand and expectations. The study revealed a lack of collective wisdom as to how scope of practice may be enhanced, and an accompanying lack of organisational readiness to facilitate the broad changes needed to implement a different practice role. In response to these findings, the SCOPED model was developed as a tool to assist health services explore and implement an enhanced scope of practice for the second level nurse. PMID:18844530

  20. Recruiting Honours Students in the Face of Market Demand for Pass Degrees: A Case Study.

    ERIC Educational Resources Information Center

    Powles, Margaret; Patrick, Kate

    1991-01-01

    A study investigated Australian students' reasons for choosing an extra year's study (honors) in economics when good employment opportunities were available without the added training. Factors considered include student background, current circumstances, achievement, course structure, perceived demand for honors graduates, opportunity costs, and…

  1. Dynamic Response of the Environment at the Moon (DREAM): Providing Opportunities for Students and Teachers to Learn About the Solar-lunar Environmental Connection

    NASA Astrophysics Data System (ADS)

    Bleacher, L.; Weir, H. M.; Twu, Y.; Farrell, W. M.; Gross, N. A.

    2009-12-01

    The Dynamic Response of the Environment at the Moon (DREAM) team is one of seven teams comprising the NASA Lunar Science Institute. DREAM’s goal is to reveal, advance, and test the extremes of the solar-lunar environmental connection. DREAM’s education and outreach (E/PO) program is focused on student and teacher participation with scientists. The primary component of the DREAM E/PO program is two Lunar Extreme Workshops (LEWs) and the supporting materials developed for each LEW. The workshops will bring together scientists and modelers from the DREAM team with advanced high school and/or community college students and their teachers. The LEWs will allow student/teacher participants to interact directly with the scientists and to experience the process of science in action. Participation in LEWs and pre-LEW training will expose students to science, technology, engineering, and math (STEM) careers and engage them in learning new STEM content. During the two LEWs, the new, integrated lunar models developed by the DREAM team will be tested using extreme environmental drivers. These extreme events include: 1) solar storms and human excursion into Shackleton Crater and 2) human activity/lunar excavation and impact cratering. Although the LEWs will be complex in nature, the students and teachers will receive extensive pre-LEW training via access to online curricular resources already in development and Webinars with DREAM science team members, during which the students/teachers will get to know the team members and put their new knowledge into context. The curricular materials will include resources and activities pertaining to space weather, plasma, electricity, circuits, magnetism, magnetospheres, exospheres, impact cratering, and modeling. The activities are being mapped to the National Science Education Standards and the American Association for the Advancement of Science’s Benchmarks for Science Literacy. Students will be encouraged to read and review

  2. 5 CFR 1631.32 - Procedure in the event of a demand for disclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AVAILABILITY OF RECORDS Production in Response to Subpoenas or Demands of Courts or Other Authorities § 1631.32... concerned replies to or appears before the court or other authority. (b) If response to the demand is... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Procedure in the event of a demand...

  3. 5 CFR 2502.32 - Procedure in the event of a demand for disclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... THE PRESIDENT AVAILABILITY OF RECORDS Production in Response to Subpoenas or Demands of Courts or... concerned replies to or appears before the court or other authority. (b) If response to the demand is... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Procedure in the event of a demand...

  4. CAREER GUIDE FOR DEMAND OCCUPATIONS.

    ERIC Educational Resources Information Center

    LEE, E.R.; WELCH, JOHN L.

    THIS PUBLICATION UPDATES THE "CAREER GUIDE FOR DEMAND OCCUPATIONS" PUBLISHED IN 1959 AND PROVIDES COUNSELORS WITH INFORMATION ABOUT OCCUPATIONS IN DEMAND IN MANY AREAS WHICH REQUIRE PREEMPLOYMENT TRAINING. IT PRESENTS, IN COLUMN FORM, THE EDUCATION AND OTHER TRAINING USUALLY REQUIRED BY EMPLOYERS, HIGH SCHOOL SUBJECTS OF PARTICULAR PERTINENCE TO…

  5. Career Opportunities in Physiology.

    ERIC Educational Resources Information Center

    Physiologist, 1984

    1984-01-01

    Physiologists offer their viewpoints on career opportunities in the pharmaceutical industries. A director's and an employee's views of what a director of pharmacology looks for in a physiologist are included. (JN)

  6. Opportunities with thermoplastics.

    PubMed

    Vaahs, Tilo

    2003-04-01

    Whether as substitutes for glass and metal, or completely novel injection moulded applications, engineering polymers offer a range of opportunities for developing cost-effective, safe and smart medical devices.

  7. Demands, values, and burnout

    PubMed Central

    Leiter, Michael P.; Frank, Erica; Matheson, Timothy J.

    2009-01-01

    OBJECTIVE T o explore the interaction between workload and values congruence (personal values with health care system values) in the context of burnout and physician engagement and to explore the relative importance of these factors by sex, given the distinct work patterns of male and female physicians. DESIGN National mailed survey. SETTING Canada. PARTICIPANTS A random sample of 8100 Canadian physicians (response rate 40%, N = 3213); 2536 responses (from physicians working more than 35 hours per week) were analyzed. MAIN OUTCOME MEASURES Levels of burnout, values congruence, and workload, by sex, measured by the Maslach Burnout Inventory—General Scale and the Areas of Worklife Scale. RESULTS Results showed a moderate level of burnout among Canadian physicians, with relatively positive scores on exhaustion, average scores on cynicism, and mildly negative scores on professional efficacy. A series of multiple regression analyses confirmed parallel main effect contributions from manageable workload and values congruence. Both workload and values congruence predicted exhaustion and cynicism for men and women (P = .001). Only values congruence provided a significant prediction of professional efficacy for both men and women (P = .001) These predictors interacted for women on all 3 aspects of burnout (exhaustion, cynicism, and diminished efficacy). Howevever, overall levels of the burnout indicators departed only modestly from normative levels. CONCLUSION W orkload and values congruence make distinct contributions to physician burnout. Work overload contributes to predicting exhaustion and cynicism; professional values crises contribute to predicting exhaustion, cynicism, and low professional efficacy. The interaction of values and workload for women in particular has implications for the distinct work-life patterns of male and female physicians. Specifically, the congruence of individual values with values inherent in the health care system appeared to be of greater

  8. Opportunity Spies Its Backshell

    NASA Technical Reports Server (NTRS)

    2004-01-01

    From its new location at the inner edge of the small crater surrounding it, the Mars Exploration Rover Opportunity was able to look out to the plains where its backshell (left) and parachute (right) landed. Opportunity is currently investigating a rock outcropping with its suite of robotic geologic tools. This approximate true-color image was created by combining data from the panoramic camera's red, green and blue filters.

  9. Education and the medical record professional: obligation or opportunity?

    PubMed

    Barr, C J

    1988-12-01

    The present health care environment demands an emphasis on continuing education and the constant upgrading of ones' professional skills and abilities. The pressure to update and maintain skills can be a burden on the members of our profession, or it can pose exciting challenges to our creativity. This article discusses the career opportunities available to medical record professionals in the area of providing educational programs to other health care professionals, and some ways to take advantage of these opportunities.

  10. New hedonic technique for estimating attribute demand: an application to the demand for automobile fuel efficiency

    SciTech Connect

    Atkinson, S.E.; Halvorsen, R.

    1984-08-01

    A new hedonic procedure is applied to estimate the effects of gasoline price on the demand for automobile attributes and fuel efficiency. Direct application of a comparative statics analysis circumvents the problems of identification and severe multicollinearity affecting previous hedonic studies. The results indicate that the effect of induced changes in automobile attributes in response to increases in the price of gasoline is to substantially increase fuel efficiency. The estimated elasticities of fuel efficiency with respect to the price of gasoline imply that the long-run own-price elasticity of demand for gasoline is greater than unity. 31 references.

  11. Office of Equal Opportunity Programs

    NASA Technical Reports Server (NTRS)

    Chin, Jennifer L.

    2004-01-01

    The NASA Glenn Office of Equal Opportunity Programs works to provide quality service for all programs and/or to assist the Center in becoming a model workplace. During the summer of 2004, I worked with Deborah Cotleur along with other staff members to create and modify customer satisfaction surveys. This office aims to assist in developing a model workplace by providing functions as a change agent to the center by serving as an advisor to management to ensure equity throughout the Center. In addition, the office serves as a mediator for the Center in addressing issues and concerns. Lastly, the office provides assistance to employees to enable attainment of personal and organizational goals. The Office of Equal Opportunities is a staff office which reports and provides advice to the Center Director and Executive Leadership, implements laws, regulations, and presidential executive orders, and provides center wide leadership and assistance to NASA GRC employees. Some of the major responsibilities of the office include working with the discrimination complaints program, special emphasis programs (advisory groups), management support, monitoring and evaluation, contract compliance, and community outreach. During my internship in this office, my main objective was to create four customer satisfaction surveys based on EO retreats, EO observances, EO advisory boards, and EO mediation/counseling. I created these surveys after conducting research on past events and surveys as well as similar survey research created and conducted by other NASA centers, program for EO Advisory group members, leadership training sessions for supervisors, preventing sexual harassment training sessions, and observance events. I also conducted research on the style and format from feedback surveys from the Marshall Equal Opportunity website, the Goddard website, and the main NASA website. Using the material from the Office of Equal Opportunity Programs at Glenn Research Center along with my

  12. Research opportunities to improve DSM impact estimates

    SciTech Connect

    Misuriello, H.; Hopkins, M.E.F.

    1992-03-01

    This report was commissioned by the California Institute for Energy Efficiency (CIEE) as part of its research mission to advance the energy efficiency and productivity of all end-use sectors in California. Our specific goal in this effort has been to identify viable research and development (R&D) opportunities that can improve capabilities to determine the energy-use and demand reductions achieved through demand-side management (DSM) programs and measures. We surveyed numerous practitioners in California and elsewhere to identify the major obstacles to effective impact evaluation, drawing on their collective experience. As a separate effort, we have also profiled the status of regulatory practices in leading states with respect to DSM impact evaluation. We have synthesized this information, adding our own perspective and experience to those of our survey-respondent colleagues, to characterize today`s state of the art in impact-evaluation practices. This scoping study takes a comprehensive look at the problems and issues involved in DSM impact estimates at the customer-facility or site level. The major portion of our study investigates three broad topic areas of interest to CIEE: Data analysis issues, field-monitoring issues, issues in evaluating DSM measures. Across these three topic areas, we have identified 22 potential R&D opportunities, to which we have assigned priority levels. These R&D opportunities are listed by topic area and priority.

  13. Research opportunities to improve DSM impact estimates

    SciTech Connect

    Misuriello, H.; Hopkins, M.E.F. )

    1992-03-01

    This report was commissioned by the California Institute for Energy Efficiency (CIEE) as part of its research mission to advance the energy efficiency and productivity of all end-use sectors in California. Our specific goal in this effort has been to identify viable research and development (R D) opportunities that can improve capabilities to determine the energy-use and demand reductions achieved through demand-side management (DSM) programs and measures. We surveyed numerous practitioners in California and elsewhere to identify the major obstacles to effective impact evaluation, drawing on their collective experience. As a separate effort, we have also profiled the status of regulatory practices in leading states with respect to DSM impact evaluation. We have synthesized this information, adding our own perspective and experience to those of our survey-respondent colleagues, to characterize today's state of the art in impact-evaluation practices. This scoping study takes a comprehensive look at the problems and issues involved in DSM impact estimates at the customer-facility or site level. The major portion of our study investigates three broad topic areas of interest to CIEE: Data analysis issues, field-monitoring issues, issues in evaluating DSM measures. Across these three topic areas, we have identified 22 potential R D opportunities, to which we have assigned priority levels. These R D opportunities are listed by topic area and priority.

  14. Policy responses to the productivity slowdown

    SciTech Connect

    Nordhaus, W.D.

    1980-06-01

    A slowdown in the growth rate of labor productivity in the US (productivity slowdown) is discussed in this review. The generally accepted reasons for the slowdown are presented. A theory of depletion vs obstacle in describing productivity slowdown is presented. Policy responses to problems of productivity slowdown are described. Views presented include: (a) a change of taste toward no growth philosophies; (b) undersaving and underinvesting; (c) self-inflicted wounds i.e. payroll taxes, minimum wage, trade restrictions, etc.; and (d) depletion in extractive industries, investment opportunities, and inventions. Specific policy responses are discussed including: anti-inflation policy; demand management policies; investment; energy; and regulation.

  15. Health care on demand: four telehealth priorities for 2016.

    PubMed

    Grube, Mark E; Kaufman, Kenneth; Clarin, Dan; O'Riordan, Jason

    2016-01-01

    Consumers who are accustomed to on-demand, virtual services are looking for more convenient ways to access health care. Giving patients the opportunity to connect with physicians remotely can promote higher patient satisfaction and engagement. Telehealth options may have a high start-up cost, but that cost is likely well-justified by the potential to enhance quality, outcomes, and customer attraction and satisfaction/retention over the long-term.

  16. Health care on demand: four telehealth priorities for 2016.

    PubMed

    Grube, Mark E; Kaufman, Kenneth; Clarin, Dan; O'Riordan, Jason

    2016-01-01

    Consumers who are accustomed to on-demand, virtual services are looking for more convenient ways to access health care. Giving patients the opportunity to connect with physicians remotely can promote higher patient satisfaction and engagement. Telehealth options may have a high start-up cost, but that cost is likely well-justified by the potential to enhance quality, outcomes, and customer attraction and satisfaction/retention over the long-term. PMID:26863834

  17. Residential Demand Module - NEMS Documentation

    EIA Publications

    2014-01-01

    Model Documentation - Documents the objectives, analytical approach, and development of the National Energy Modeling System (NEMS) Residential Sector Demand Module. The report catalogues and describes the model assumptions, computational methodology, parameter estimation techniques, and FORTRAN source code.

  18. Industrial Demand Module - NEMS Documentation

    EIA Publications

    2014-01-01

    Documents the objectives, analytical approach, and development of the National Energy Modeling System (NEMS) Industrial Demand Module. The report catalogues and describes model assumptions, computational methodology, parameter estimation techniques, and model source code.

  19. Pollution Prevention Opportunity Assessment for Landscape Waste

    SciTech Connect

    Phillips, N.M.; Raubfogel, S.J.

    1996-08-01

    DOE orders mandate the development of a waste minimization program. The program`s goals are to: reduce volumes of wastes and toxicity; implement a system of tracking and reporting improvements; and devise a method for performing tasks. To satisfy the requirements of this program, Sandia conducts pollution prevention opportunity assessments (PPOAs) to identify waste-generating processes. The information collected from a PPOA then is used to identify waste minimization opportunities. This pollution prevention opportunity assessment was conducted using Sandia`s new methodology for prioritizing, evaluating and managing site-wide waste streams. This new methodology and the list of priority waste streams are described in the wastes revision of the Pollution Prevention Opportunity Assessment Plant. This PPOA addresses landscape waste minimization, partially in response to recent legislation and regulations.

  20. New Suborbital Flight Opportunities and Funding

    NASA Astrophysics Data System (ADS)

    Saltman, Alexander

    2013-07-01

    New opportunities for suborbital research are on the horizon. Reusable suborbital vehicles will offer immediate and routine space access for scientific payloads, provide access to altitudes around 100 kilometers, create opportunities for low-cost monitoring of upper atmospheric phenomena, as well as small scale solar observation. Reduced operational cost and quick turn-around will enable equipment to be flown opportunistically, in response to specific solar activity, or in continuous test and improvement cycles. Suborbital test flights will also provide opportunities to test prospective satellite instruments in an extended microgravity environment before being launched to orbit, raising the technology readiness level (TRL) of flight hardware and reducing the risk of anomalies during missions. I discuss the capabilities of emerging suborbital vehicles, payload and integration requirements, and funding opportunities for suborbital flights at NASA.