METCAN demonstration manual, version 1.0

NASA Technical Reports Server (NTRS)

Lee, H.-J.; Murthy, P. L. N.

1992-01-01

The various features of the Metal Matrix Composite Analyzer (METCAN) computer program to simulate the high temperature nonlinear behavior of continuous fiber reinforced metal matrix composites are demonstrated. Different problems are used to demonstrate various capabilities of METCAN for both static and cyclic analyses. A complete description of the METCAN output file is also included to help interpret results.

A New Technique for Mitigating Risk on US College Campuses

ERIC Educational Resources Information Center

Hughes, Stephanie; White, Rebecca J.; Hertz, Giles

2008-01-01

High-profile criminal acts continue to plague United States (US) college campuses despite recent efforts to implement more aggressive risk mitigation practices, such as criminal background checks. Despite these efforts, incidents such as the most recent shootings at Virginia Polytechnic Institute and State University continue to demonstrate that,…

High-precision terahertz frequency modulated continuous wave imaging method using continuous wavelet transform

NASA Astrophysics Data System (ADS)

Zhou, Yu; Wang, Tianyi; Dai, Bing; Li, Wenjun; Wang, Wei; You, Chengwu; Wang, Kejia; Liu, Jinsong; Wang, Shenglie; Yang, Zhengang

2018-02-01

Inspired by the extensive application of terahertz (THz) imaging technologies in the field of aerospace, we exploit a THz frequency modulated continuous-wave imaging method with continuous wavelet transform (CWT) algorithm to detect a multilayer heat shield made of special materials. This method uses the frequency modulation continuous-wave system to catch the reflected THz signal and then process the image data by the CWT with different basis functions. By calculating the sizes of the defects area in the final images and then comparing the results with real samples, a practical high-precision THz imaging method is demonstrated. Our method can be an effective tool for the THz nondestructive testing of composites, drugs, and some cultural heritages.

Nanofiber adsorbents for high productivity continuous downstream processing.

PubMed

Hardick, Oliver; Dods, Stewart; Stevens, Bob; Bracewell, Daniel G

2015-11-10

An ever increasing focus is being placed on the manufacturing costs of biotherapeutics. The drive towards continuous processing offers one opportunity to address these costs through the advantages it offers. Continuous operation presents opportunities for real-time process monitoring and automated control with potential benefits including predictable product specification, reduced labour costs, and integration with other continuous processes. Specifically to chromatographic operations continuous processing presents an opportunity to use expensive media more efficiently while reducing their size and therefore cost. Here for the first time we show how a new adsorbent material (cellulosic nanofibers) having advantageous convective mass transfer properties can be combined with a high frequency simulated moving bed (SMB) design to provide superior productivity in a simple bioseparation. Electrospun polymeric nanofiber adsorbents offer an alternative ligand support surface for bioseparations. Their non-woven fiber structure with diameters in the sub-micron range creates a remarkably high surface area material that allows for rapid convective flow operations. A proof of concept study demonstrated the performance of an anion exchange nanofiber adsorbent based on criteria including flow and mass transfer properties, binding capacity, reproducibility and life-cycle performance. Binding capacities of the DEAE adsorbents were demonstrated to be 10mg/mL, this is indeed only a fraction of what is achievable from porous bead resins but in combination with a very high flowrate, the productivity of the nanofiber system is shown to be significant. Suitable packing into a flow distribution device has allowed for reproducible bind-elute operations at flowrates of 2,400 cm/h, many times greater than those used in typical beaded systems. These characteristics make them ideal candidates for operation in continuous chromatography systems. A SMB system was developed and optimised to demonstrate the productivity of nanofiber adsorbents through rapid bind-elute cycle times of 7s which resulted in a 15-fold increase in productivity compared with packed bed resins. Reproducible performance of BSA purification was demonstrated using a 2-component protein solution of BSA and cytochrome c. The SMB system exploits the advantageous convective mass transfer properties of nanofiber adsorbents to provide productivities much greater than those achievable with conventional chromatography media. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

Generation of tunable, high repetition rate optical frequency combs using on-chip silicon modulators

NASA Astrophysics Data System (ADS)

Nagarjun, K. P.; Jeyaselvan, Vadivukarassi; Selvaraja, Shankar Kumar; Supradeepa, V. R.

2018-04-01

We experimentally demonstrate tunable, highly-stable frequency combs with high repetition-rates using a single, charge injection based silicon PN modulator. In this work, we demonstrate combs in the C-band with over 8 lines in a 20-dB bandwidth. We demonstrate continuous tuning of the center frequency in the C-band and tuning of the repetition-rate from 7.5GHz to 12.5GHz. We also demonstrate through simulations the potential for bandwidth scaling using an optimized silicon PIN modulator. We find that, the time varying free carrier absorption due to carrier injection, an undesirable effect in data modulators, assists here in enhancing flatness in the generated combs.

Simple modules for high efficiency conversion of standard ytterbium doped fiber lasers into octave spanning continuous-wave supercontinuum sources

NASA Astrophysics Data System (ADS)

Arun, S.; Choudhury, Vishal; Balaswamy, V.; Supradeepa, V. R.

2018-02-01

We have demonstrated a 34 W continuous wave supercontinuum using the standard telecom fiber (SMF 28e). The supercontinuum spans over a bandwidth of 1000 nm (>1 octave) from 880nm to 1900 nm with a substantial power spectral density of >1mW/nm from 880-1350 nm and 50-100mW/nm in 1350-1900 nm. The distributed feedback Raman laser architecture was used for pumping the supercontinuum which ensured high efficiency Raman conversions and helped in achieving a very high efficiency of 44% for supercontinuum generation. Using this architecture, Yb laser operating at any wavelength can be used for generating the supercontinuum and this was demonstrated by using two different Yb lasers operating at 1117nm and 1085 nm to pump the supercontinuum.

CONTINUED ASSESSMENT OF A HIGH-VELOCITY FABRIC FILTRATION SYSTEM USED TO CONTROL FLY ASH EMISSIONS

EPA Science Inventory

The report gives results of a full-scale investigation of the performance of a variety of filter media, to provide technical and economic information under high-velocity conditions (high gas/cloth ratio). The fly ash emission studies demonstrated that woven fiberglass fabrics and...

Biochemical separations by continuous-bed chromatography.

PubMed

Tisch, T L; Frost, R; Liao, J L; Lam, W K; Remy, A; Scheinpflug, E; Siebert, C; Song, H; Stapleton, A

1998-08-07

Innovations in column-packing media for biomolecule purification have progressed from large spherical, porous polysaccharide beads to advanced polymeric supports. Continuous-bed technology is a radical new technology for chromatography based on the polymerization of advanced monomers and ionomers directly in the chromatographic column. The polymer chains form aggregates which coalesce into a dense, homogeneous network of interconnected nodules consisting of microparticles with an average diameter of 3000 A. The voids or channels between the nodules are large enough to permit a high hydrodynamic flow. Due to the high cross-linking of the polymer matrix, the surface of each nodule is nonporous yet the polymeric microparticles provide a very large surface area for high binding capacity. This paper will demonstrate the properties and advantages of using a continuous bed support for high resolution biomolecule separations at high flow-rates without sacrificing capacity.

Progress in the Production of JP-8 Based Hydrogen and Advanced Tactical Fuels for Military Applications

DTIC Science & Technology

2011-02-01

of a multi- year program to develop, optimize, and demonstrate the military viability of a technology for on-demand production of high...continuous reactor system used for kinetic rate data experiment 86 52 Schematic of a differential reactor. The catalyst bed is kept small , and...program to develop, optimize, and demonstrate the military viability of a technology for on-demand production of high-pressure hydrogen for fuel

Ultra-slim flexible glass for roll-to-roll electronic device fabrication

NASA Astrophysics Data System (ADS)

Garner, Sean; Glaesemann, Scott; Li, Xinghua

2014-08-01

As displays and electronics evolve to become lighter, thinner, and more flexible, the choice of substrate continues to be critical to their overall optimization. The substrate directly affects improvements in the designs, materials, fabrication processes, and performance of advanced electronics. With their inherent benefits such as surface quality, optical transmission, hermeticity, and thermal and dimensional stability, glass substrates enable high-quality and long-life devices. As substrate thicknesses are reduced below 200 μm, ultra-slim flexible glass continues to provide these inherent benefits to high-performance flexible electronics such as displays, touch sensors, photovoltaics, and lighting. In addition, the reduction in glass thickness also allows for new device designs and high-throughput, continuous manufacturing enabled by R2R processes. This paper provides an overview of ultra-slim flexible glass substrates and how they enable flexible electronic device optimization. Specific focus is put on flexible glass' mechanical reliability. For this, a combination of substrate design and process optimizations has been demonstrated that enables R2R device fabrication on flexible glass. Demonstrations of R2R flexible glass processes such as vacuum deposition, photolithography, laser patterning, screen printing, slot die coating, and lamination have been made. Compatibility with these key process steps has resulted in the first demonstration of a fully functional flexible glass device fabricated completely using R2R processes.

Precise Morphology Control and Continuous Fabrication of Perovskite Solar Cells Using Droplet-Controllable Electrospray Coating System.

PubMed

Hong, Seung Chan; Lee, Gunhee; Ha, Kyungyeon; Yoon, Jungjin; Ahn, Namyoung; Cho, Woohyung; Park, Mincheol; Choi, Mansoo

2017-03-08

Herein, we developed a novel electrospray coating system for continuous fabrication of perovskite solar cells with high performance. Our system can systemically control the size of CH 3 NH 3 PbI 3 precursor droplets by modulating the applied electrical potential, shown to be a crucial factor for the formation of perovskite films. As a result, we have obtained pinhole-free and large grain-sized perovskite solar cells, yielding the best PCE of 13.27% with little photocurrent hysteresis. Furthermore, the average PCE through the continuous coating process was 11.56 ± 0.52%. Our system demonstrates not only the high reproducibility but also a new way to commercialize high-quality perovskite solar cells.

A high temperature drop-tube and packed-bed solar reactor for continuous biomass gasification

NASA Astrophysics Data System (ADS)

Bellouard, Quentin; Abanades, Stéphane; Rodat, Sylvain; Dupassieux, Nathalie

2017-06-01

Biomass gasification is an attractive process to produce high-value syngas. Utilization of concentrated solar energy as the heat source for driving reactions increases the energy conversion efficiency, saves biomass resource, and eliminates the needs for gas cleaning and separation. A high-temperature tubular solar reactor combining drop tube and packed bed concepts was used for continuous solar-driven gasification of biomass. This 1 kW reactor was experimentally tested with biomass feeding under real solar irradiation conditions at the focus of a 2 m-diameter parabolic solar concentrator. Experiments were conducted at temperatures ranging from 1000°C to 1400°C using wood composed of a mix of pine and spruce (bark included) as biomass feedstock. The aim of this study was to demonstrate the feasibility of syngas production in this reactor concept and to prove the reliability of continuous biomass gasification processing using solar energy. The study first consisted of a parametric study of the gasification conditions to obtain an optimal gas yield. The influence of temperature and oxidizing agent (H2O or CO2) on the product gas composition was investigated. The study then focused on solar gasification during continuous biomass particle injection for demonstrating the feasibility of a continuous process. Regarding the energy conversion efficiency of the lab scale reactor, energy upgrade factor of 1.21 and solar-to-fuel thermochemical efficiency up to 28% were achieved using wood heated up to 1400°C.

Controlled assembly of organic whispering-gallery-mode microlasers as highly sensitive chemical vapor sensors.

PubMed

Gao, Miaomiao; Wei, Cong; Lin, Xianqing; Liu, Yuan; Hu, Fengqin; Zhao, Yong Sheng

2017-03-09

We demonstrate the fabrication of organic high Q active whispering-gallery-mode (WGM) resonators from π-conjugated polymer by a controlled emulsion-solvent-evaporation method, which can simultaneously provide optical gain and act as an effective resonant cavity. By measuring the shift of their lasing modes on exposure to organic vapor, we successfully monitored the slight concentration variation in the chemical gas. These microlaser sensors demonstrated high detection sensitivity and good signal repeatability under continuous chemical gas treatments. The results offer an effective strategy to design miniaturized optical sensors.

Toward continuous-wave operation of organic semiconductor lasers

PubMed Central

Sandanayaka, Atula S. D.; Matsushima, Toshinori; Bencheikh, Fatima; Yoshida, Kou; Inoue, Munetomo; Fujihara, Takashi; Goushi, Kenichi; Ribierre, Jean-Charles; Adachi, Chihaya

2017-01-01

The demonstration of continuous-wave lasing from organic semiconductor films is highly desirable for practical applications in the areas of spectroscopy, data communication, and sensing, but it still remains a challenging objective. We report low-threshold surface-emitting organic distributed feedback lasers operating in the quasi–continuous-wave regime at 80 MHz as well as under long-pulse photoexcitation of 30 ms. This outstanding performance was achieved using an organic semiconductor thin film with high optical gain, high photoluminescence quantum yield, and no triplet absorption losses at the lasing wavelength combined with a mixed-order distributed feedback grating to achieve a low lasing threshold. A simple encapsulation technique greatly reduced the laser-induced thermal degradation and suppressed the ablation of the gain medium otherwise taking place under intense continuous-wave photoexcitation. Overall, this study provides evidence that the development of a continuous-wave organic semiconductor laser technology is possible via the engineering of the gain medium and the device architecture. PMID:28508042

Toward continuous-wave operation of organic semiconductor lasers.

PubMed

Sandanayaka, Atula S D; Matsushima, Toshinori; Bencheikh, Fatima; Yoshida, Kou; Inoue, Munetomo; Fujihara, Takashi; Goushi, Kenichi; Ribierre, Jean-Charles; Adachi, Chihaya

2017-04-01

The demonstration of continuous-wave lasing from organic semiconductor films is highly desirable for practical applications in the areas of spectroscopy, data communication, and sensing, but it still remains a challenging objective. We report low-threshold surface-emitting organic distributed feedback lasers operating in the quasi-continuous-wave regime at 80 MHz as well as under long-pulse photoexcitation of 30 ms. This outstanding performance was achieved using an organic semiconductor thin film with high optical gain, high photoluminescence quantum yield, and no triplet absorption losses at the lasing wavelength combined with a mixed-order distributed feedback grating to achieve a low lasing threshold. A simple encapsulation technique greatly reduced the laser-induced thermal degradation and suppressed the ablation of the gain medium otherwise taking place under intense continuous-wave photoexcitation. Overall, this study provides evidence that the development of a continuous-wave organic semiconductor laser technology is possible via the engineering of the gain medium and the device architecture.

The cryogenic wind tunnel for high Reynolds number testing. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Kilgore, R. A.

1974-01-01

Experiments performed at the NASA Langley Research Center in a cryogenic low-speed continuous-flow tunnel and in a cryogenic transonic continuous-flow pressure tunnel have demonstrated the predicted changes in Reynolds number, drive power, and fan speed with temperature, while operating with nitrogen as the test gas. The experiments have also demonstrated that cooling to cryogenic temperatures by spraying liquid nitrogen directly into the tunnel circuit is practical and that tunnel temperature can be controlled within very close limits. Whereas most types of wind tunnel could operate with advantage at cryogenic temperatures, the continuous-flow fan-driven tunnel is particularly well suited to take full advantage of operating at these temperatures. A continuous-flow fan-driven cryogenic tunnel to satisfy current requirements for test Reynolds number can be constructed and operated using existing techniques. Both capital and operating costs appear acceptable.

Frequency-tunable continuous-wave terahertz sources based on GaAs plasmonic photomixers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Shang-Hua; Jarrahi, Mona; Electrical Engineering Department, University of California Los Angeles, Los Angeles, California 90095

2015-09-28

We present frequency-tunable, continuous-wave terahertz sources based on GaAs plasmonic photomixers, which offer high terahertz radiation power levels at 50% radiation duty cycle. The use of plasmonic contact electrodes enhances photomixer quantum efficiency while maintaining its ultrafast operation by concentrating a large number of photocarriers in close proximity to the device contact electrodes. Additionally, the relatively high thermal conductivity and high resistivity of GaAs allow operation under high optical pump power levels and long duty cycles without reaching the thermal breakdown limit of the photomixer. We experimentally demonstrate continuous-wave terahertz radiation with a radiation frequency tuning range of more thanmore » 2 THz and a record-high radiation power of 17 μW at 1 THz through plasmonic photomixers fabricated on a low temperature grown GaAs substrate at 50% radiation duty cycle.« less

Robust continuous clustering

PubMed Central

Shah, Sohil Atul

2017-01-01

Clustering is a fundamental procedure in the analysis of scientific data. It is used ubiquitously across the sciences. Despite decades of research, existing clustering algorithms have limited effectiveness in high dimensions and often require tuning parameters for different domains and datasets. We present a clustering algorithm that achieves high accuracy across multiple domains and scales efficiently to high dimensions and large datasets. The presented algorithm optimizes a smooth continuous objective, which is based on robust statistics and allows heavily mixed clusters to be untangled. The continuous nature of the objective also allows clustering to be integrated as a module in end-to-end feature learning pipelines. We demonstrate this by extending the algorithm to perform joint clustering and dimensionality reduction by efficiently optimizing a continuous global objective. The presented approach is evaluated on large datasets of faces, hand-written digits, objects, newswire articles, sensor readings from the Space Shuttle, and protein expression levels. Our method achieves high accuracy across all datasets, outperforming the best prior algorithm by a factor of 3 in average rank. PMID:28851838

From CONT to VGOS: the Evolution of the CONT Campaigns

NASA Astrophysics Data System (ADS)

Thomas, Cynthia C.; Behrend, Dirk; MacMillan, Daniel S.

2016-12-01

Continuous VLBI campaigns (CONT) started in 1994 with the goal of demonstrating state-of-the-art VLBI over a continuous period of time. The first CONT was followed by campaigns in 1995 and 1996. After a six year hiatus, CONT campaigns were organized approximately every three years from 2002 through 2014. In this paper we primarily focus on the cornerstones of each CONT campaign. Specifically, we review the developments in networks, scheduling techniques, recording media, correlation, and other resources used. A timeline of the history of the CONTs and the goals for future campaigns will be presented. The CONTs used a significant amount of IVS resources to produce a large volume of high quality data and demonstrated the advantages of continuous observing which will soon be realized with VGOS.

Continuous variable quantum key distribution with a real local oscillator using simultaneous pilot signals.

PubMed

Kleis, Sebastian; Rueckmann, Max; Schaeffer, Christian G

2017-04-15

In this Letter, we propose a novel implementation of continuous variable quantum key distribution that operates with a real local oscillator placed at the receiver site. In addition, pulsing of the continuous wave laser sources is not required, leading to an extraordinary practical and secure setup. It is suitable for arbitrary schemes based on modulated coherent states and heterodyne detection. The shown results include transmission experiments, as well as an excess noise analysis applying a discrete 8-state phase modulation. Achievable key rates under collective attacks are estimated. The results demonstrate the high potential of the approach to achieve high secret key rates at relatively low effort and cost.

Long-Term Psychosocial Consequences of Peer Victimization: From Elementary to High School

ERIC Educational Resources Information Center

Smithyman, Thomas F.; Fireman, Gary D.; Asher, Yvonne

2014-01-01

Prior research has demonstrated that victims of peer victimization show reduced psychological adjustment, social adjustment, and physical well-being compared with nonvictims. However, little research has addressed whether this maladjustment continues over the long term. This study examined adjustment in 72 high school students who had participated…

Monolithic Microwave Integrated Circuit (MMIC) Phased Array Demonstrated With ACTS

NASA Technical Reports Server (NTRS)

1996-01-01

Monolithic Microwave Integrated Circuit (MMIC) arrays developed by the NASA Lewis Research Center and the Air Force Rome Laboratory were demonstrated in aeronautical terminals and in mobile or fixed Earth terminals linked with NASA's Advanced Communications Technology Satellite (ACTS). Four K/Ka-band experimental arrays were demonstrated between May 1994 and May 1995. Each array had GaAs MMIC devices at each radiating element for electronic beam steering and distributed power amplification. The 30-GHz transmit array used in uplinks to ACTS was developed by Lewis and Texas Instruments. The three 20-GHz receive arrays used in downlinks from ACTS were developed in cooperation with the Air Force Rome Laboratory, taking advantage of existing Air Force integrated-circuit, active-phased-array development contracts with the Boeing Company and Lockheed Martin Corporation. Four demonstrations, each related to an application of high interest to both commercial and Department of Defense organizations, were conducted. The location, type of link, and the data rate achieved for each of the applications is shown. In one demonstration-- an aeronautical terminal experiment called AERO-X--a duplex voice link between an aeronautical terminal on the Lewis Learjet and ACTS was achieved. Two others demonstrated duplex voice links (and in one case, interactive video links as well) between ACTS and an Army high-mobility, multipurpose wheeled vehicle (HMMWV, or "humvee"). In the fourth demonstration, the array was on a fixed mount and was electronically steered toward ACTS. Lewis served as project manager for all demonstrations and as overall system integrator. Lewis engineers developed the array system including a controller for open-loop tracking of ACTS during flight and HMMWV motion, as well as a laptop data display and recording system used in all demonstrations. The Jet Propulsion Laboratory supported the AERO-X program, providing elements of the ACTS Mobile Terminal. The successful performance of experimental, proof-of-concept MMIC K/Ka-band arrays developed with U.S. industry in field demonstrations with ACTS indicates that high density MMIC integration at 20 and 30 GHz is indeed feasible. The successful development and demonstration of the MMIC array systems was possible only because of significant intergovernmental and Government/industry cooperation and the high level of teamwork within Lewis. The results provide a strong incentive for continuing the focused development of MMIC-array technology for satellite communications applications, with emphasis on packaging and cost issues, and for continuing the planning and conducting of other appropriate demonstrations or experiments of phased-array technology with ACTS. Given the present pressures on reducing funding for research and development in Government and industry, the extent to which this can be continued in a cooperative manner will determine whether MMIC array technology will make the transition from the proof-of-concept level to the operational system level.

Smoke Signals: Adolescent Smoking and School Continuation. Working Papers Series. SAN06-05

ERIC Educational Resources Information Center

Cook, Philip J.; Hutchinson, Rebecca

2006-01-01

This paper presents an exploratory analysis using NLSY97 data of the relationship between the likelihood of school continuation and the choices of whether to smoke or drink. We demonstrate that in the United States as of the late 1990s, smoking in 11th-grade was a uniquely powerful predictor of whether the student finished high school, and if so…

High-efficiency reconciliation for continuous variable quantum key distribution

NASA Astrophysics Data System (ADS)

Bai, Zengliang; Yang, Shenshen; Li, Yongmin

2017-04-01

Quantum key distribution (QKD) is the most mature application of quantum information technology. Information reconciliation is a crucial step in QKD and significantly affects the final secret key rates shared between two legitimate parties. We analyze and compare various construction methods of low-density parity-check (LDPC) codes and design high-performance irregular LDPC codes with a block length of 106. Starting from these good codes and exploiting the slice reconciliation technique based on multilevel coding and multistage decoding, we realize high-efficiency Gaussian key reconciliation with efficiency higher than 95% for signal-to-noise ratios above 1. Our demonstrated method can be readily applied in continuous variable QKD.

Intergenerational continuity in high conflict family environments

PubMed Central

Rothenberg, W. Andrew; Hussong, Andrea M.; Chassin, Laurie

2016-01-01

In the current study, we examined continuity in conflict across generations and explored potential mediators and moderators that could explain this continuity. We followed 246 targets from adolescence to adulthood and examined family conflict as reported by multiple reporters in targets' family of origin and current families. Results showed that conflict in the current family was strongly correlated with that of the family of origin in women but not in men. Continuity in family conflict across generations was mediated by patterns of elevated adolescent externalizing behavior in members of the second generation (G2). Additionally, analyses revealed an interaction between both G2 partners' externalizing behavior such that if one partner in the G2 family demonstrated high levels of externalizing behavior, elevated levels of family conflict resulted. Potential explanations and implications of these findings are considered. PMID:26018605

Lens-free shadow image based high-throughput continuous cell monitoring technique.

PubMed

Jin, Geonsoo; Yoo, In-Hwa; Pack, Seung Pil; Yang, Ji-Woon; Ha, Un-Hwan; Paek, Se-Hwan; Seo, Sungkyu

2012-01-01

A high-throughput continuous cell monitoring technique which does not require any labeling reagents or destruction of the specimen is demonstrated. More than 6000 human alveolar epithelial A549 cells are monitored for up to 72 h simultaneously and continuously with a single digital image within a cost and space effective lens-free shadow imaging platform. In an experiment performed within a custom built incubator integrated with the lens-free shadow imaging platform, the cell nucleus division process could be successfully characterized by calculating the signal-to-noise ratios (SNRs) and the shadow diameters (SDs) of the cell shadow patterns. The versatile nature of this platform also enabled a single cell viability test followed by live cell counting. This study firstly shows that the lens-free shadow imaging technique can provide a continuous cell monitoring without any staining/labeling reagent and destruction of the specimen. This high-throughput continuous cell monitoring technique based on lens-free shadow imaging may be widely utilized as a compact, low-cost, and high-throughput cell monitoring tool in the fields of drug and food screening or cell proliferation and viability testing. Copyright © 2012 Elsevier B.V. All rights reserved.

The High-Repetition-Rate Advanced Petawatt Laser System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haefner, Constantin; Jarboe, Jeff; Koubikova, Luci

2017-02-02

The High-Repetition-Rate Advanced Petawatt Laser System (HAPLS), being developed at Lawrence Livermore National Laboratory (LLNL), recently completed a significant milestone: demonstration of continuous operation of an all diode-pumped, high-energy femtosecond petawatt laser system. The system is now ready for delivery and integration at the European Extreme Light Infrastructure Beamlines facility project (ELI Beamlines) in the Czech Republic.

Continuous Fiber Ceramic Composites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fareed, Ali; Craig, Phillip A.

2002-09-01

Fiber-reinforced ceramic composites demonstrate the high-temperature stability of ceramics--with an increased fracture toughness resulting from the fiber reinforcement of the composite. The material optimization performed under the continuous fiber ceramic composites (CFCC) included a series of systematic optimizations. The overall goals were to define the processing window, to increase the robustinous of the process, to increase process yield while reducing costs, and to define the complexity of parts that could be fabricated.

Observation of the continuous stern-gerlach effect on an electron bound in an atomic Ion

PubMed

Hermanspahn; Haffner; Kluge; Quint; Stahl; Verdu; Werth

2000-01-17

We report on the first observation of the continuous Stern-Gerlach effect on an electron bound in an atomic ion. The measurement was performed on a single hydrogenlike ion ( 12C5+) in a Penning trap. The measured g factor of the bound electron, g = 2.001 042(2), is in excellent agreement with the theoretical value, confirming the relativistic correction at a level of 0.1%. This proves the possibility of g-factor determinations on atomic ions to high precision by using the continuous Stern-Gerlach effect. The result demonstrates the feasibility of conducting experiments on single heavy highly charged ions to test quantum electrodynamics in the strong electric field of the nucleus.

Advanced vehicle emission reduction sensor program (FED-SAVER).

DOT National Transportation Integrated Search

2008-09-01

The FED-SAVER program refined and continued the development of an in-cylinder, high temperature pressure sensor by demonstrating that it can be successfully inserted into diesel engines for routine feedback control of each individual cylinder. There ...

A new discrete dipole kernel for quantitative susceptibility mapping.

PubMed

Milovic, Carlos; Acosta-Cabronero, Julio; Pinto, José Miguel; Mattern, Hendrik; Andia, Marcelo; Uribe, Sergio; Tejos, Cristian

2018-09-01

Most approaches for quantitative susceptibility mapping (QSM) are based on a forward model approximation that employs a continuous Fourier transform operator to solve a differential equation system. Such formulation, however, is prone to high-frequency aliasing. The aim of this study was to reduce such errors using an alternative dipole kernel formulation based on the discrete Fourier transform and discrete operators. The impact of such an approach on forward model calculation and susceptibility inversion was evaluated in contrast to the continuous formulation both with synthetic phantoms and in vivo MRI data. The discrete kernel demonstrated systematically better fits to analytic field solutions, and showed less over-oscillations and aliasing artifacts while preserving low- and medium-frequency responses relative to those obtained with the continuous kernel. In the context of QSM estimation, the use of the proposed discrete kernel resulted in error reduction and increased sharpness. This proof-of-concept study demonstrated that discretizing the dipole kernel is advantageous for QSM. The impact on small or narrow structures such as the venous vasculature might by particularly relevant to high-resolution QSM applications with ultra-high field MRI - a topic for future investigations. The proposed dipole kernel has a straightforward implementation to existing QSM routines. Copyright © 2018 Elsevier Inc. All rights reserved.

Continuous engineering of nano-cocrystals for medical and energetic applications.

PubMed

Spitzer, D; Risse, B; Schnell, F; Pichot, V; Klaumünzer, M; Schaefer, M R

2014-10-10

Cocrystals, solid mixtures of different molecules on molecular scale, are supposed to be tailor made materials with improved employability compared to their pristine individual components in domains such as medicine and explosives. In medicine, cocrystals are obtained by crystallization of active pharmaceutical ingredients with precisely chosen coformers to design medicaments that demonstrate enhanced stability, high solubility, and therefore high bioavailability and optimized drug up-take. Nanoscaling may further advance these characteristica compared to their micronsized counterparts - because of a larger surface to volume ratio of nanoparticles. In the field of energetic materials, cocrystals offer the opportunity to design smart explosives, combining high reactivity with significantly reduced sensitivity, nowadays essential for a safe manipulation and handling. Furthermore, cocrystals are used in ferroelectrics, non-linear material response and electronic organics. However, state of the art batch processes produce low volume of cocrystals of variable quality and only have produced micronsized cocrystals so far, no nano-cocrystals. Here we demonstrate the continuous preparation of pharmaceutical and energetic micro- and nano-cocrystals using the Spray Flash Evaporation process. Our laboratory scale pilot plant continuously prepared up to 8 grams per hour of Caffeine/Oxalic acid 2:1, Caffeine/Glutaric acid 1:1, TNT/CL-20 1:1 and HMX/Cl-20 1:2 nano- and submicronsized cocrystals.

Continuous engineering of nano-cocrystals for medical and energetic applications

NASA Astrophysics Data System (ADS)

Spitzer, D.; Risse, B.; Schnell, F.; Pichot, V.; Klaumünzer, M.; Schaefer, M. R.

2014-10-01

Cocrystals, solid mixtures of different molecules on molecular scale, are supposed to be tailor made materials with improved employability compared to their pristine individual components in domains such as medicine and explosives. In medicine, cocrystals are obtained by crystallization of active pharmaceutical ingredients with precisely chosen coformers to design medicaments that demonstrate enhanced stability, high solubility, and therefore high bioavailability and optimized drug up-take. Nanoscaling may further advance these characteristica compared to their micronsized counterparts - because of a larger surface to volume ratio of nanoparticles. In the field of energetic materials, cocrystals offer the opportunity to design smart explosives, combining high reactivity with significantly reduced sensitivity, nowadays essential for a safe manipulation and handling. Furthermore, cocrystals are used in ferroelectrics, non-linear material response and electronic organics. However, state of the art batch processes produce low volume of cocrystals of variable quality and only have produced micronsized cocrystals so far, no nano-cocrystals. Here we demonstrate the continuous preparation of pharmaceutical and energetic micro- and nano-cocrystals using the Spray Flash Evaporation process. Our laboratory scale pilot plant continuously prepared up to 8 grams per hour of Caffeine/Oxalic acid 2:1, Caffeine/Glutaric acid 1:1, TNT/CL-20 1:1 and HMX/Cl-20 1:2 nano- and submicronsized cocrystals.

Continuous engineering of nano-cocrystals for medical and energetic applications

PubMed Central

Spitzer, D.; Risse, B.; Schnell, F.; Pichot, V.; Klaumünzer, M.; Schaefer, M. R.

2014-01-01

Cocrystals, solid mixtures of different molecules on molecular scale, are supposed to be tailor made materials with improved employability compared to their pristine individual components in domains such as medicine and explosives. In medicine, cocrystals are obtained by crystallization of active pharmaceutical ingredients with precisely chosen coformers to design medicaments that demonstrate enhanced stability, high solubility, and therefore high bioavailability and optimized drug up-take. Nanoscaling may further advance these characteristica compared to their micronsized counterparts – because of a larger surface to volume ratio of nanoparticles. In the field of energetic materials, cocrystals offer the opportunity to design smart explosives, combining high reactivity with significantly reduced sensitivity, nowadays essential for a safe manipulation and handling. Furthermore, cocrystals are used in ferroelectrics, non-linear material response and electronic organics. However, state of the art batch processes produce low volume of cocrystals of variable quality and only have produced micronsized cocrystals so far, no nano-cocrystals. Here we demonstrate the continuous preparation of pharmaceutical and energetic micro- and nano-cocrystals using the Spray Flash Evaporation process. Our laboratory scale pilot plant continuously prepared up to 8 grams per hour of Caffeine/Oxalic acid 2:1, Caffeine/Glutaric acid 1:1, TNT/CL-20 1:1 and HMX/Cl-20 1:2 nano- and submicronsized cocrystals. PMID:25300652

A Rotary Microactuator Supported on Encapsulated Microball Bearings using an Electro-Pneumatic Thrust Balance

DTIC Science & Technology

2009-01-01

Additionally, high-speed air bearings have been demonstrated in micromotors (55 000 rpm) and micro-turbomachinery (2 million rpm) [7, 8]. While...without thrust balances [11]. For applications requiring continuous rotation ( micromotors and micropumps) this hydrostatic balancing force can be...conditions for stable actuation of the micromotor leading to maximum speeds. In addition to increased speed, this device demonstrates a substantial

40 CFR 63.9634 - How do I demonstrate continuous compliance with the emission limitations that apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 14 2011-07-01 2011-07-01 false How do I demonstrate continuous... demonstrate continuous compliance by completing the requirements in paragraphs (d)(1) and (2) of this section... rate in § 63.9590(b)(1), you must demonstrate continuous compliance by completing the requirements of...

40 CFR 63.9634 - How do I demonstrate continuous compliance with the emission limitations that apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 14 2010-07-01 2010-07-01 false How do I demonstrate continuous... demonstrate continuous compliance by completing the requirements in paragraphs (d)(1) and (2) of this section... rate in § 63.9590(b)(1), you must demonstrate continuous compliance by completing the requirements of...

Biodecontamination of concrete

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, R.D.

1995-12-31

This paper describes the development and results of a demonstration for a continuous bioprocess for mixed waste treatment. A key element of the process is a unique microbial strain, which tolerates high levels of aromatic solvents and surfactants. This microorganism is the biocatalysis of the continuous flow system designed for processing stored liquid scintillation wastes. During the past year, a process demonstration has been conducted on commercial formulation of liquid scintillation cocktails (LSQ). Based on data obtained from this demonstration, the Ohio Environmental Protection Agency granted the Mound Applied Technologies Laboratory a treatability permit allowing the limited processing of actualmore » mixed waste. Since August 1994, the system has been successfully processing stored {open_quotes}hot{close_quotes} LSC waste. This paper discusses the bioprocess, rates of processing, effluent, and implications of bioprocessing for mixed waste management.« less

Continuously tunable photonic fractional Hilbert transformer using a high-contrast germanium-doped silica-on-silicon microring resonator.

PubMed

Shahoei, Hiva; Dumais, Patrick; Yao, Jianping

2014-05-01

We propose and experimentally demonstrate a continuously tunable fractional Hilbert transformer (FHT) based on a high-contrast germanium-doped silica-on-silicon (SOS) microring resonator (MRR). The propagation loss of a high-contrast germanium-doped SOS waveguide can be very small (0.02 dB/cm) while the lossless bend radius can be less than 1 mm. These characteristics lead to the fabrication of an MRR with a high Q-factor and a large free-spectral range (FSR), which is needed to implement a Hilbert transformer (HT). The SOS MRR is strongly polarization dependent. By changing the polarization direction of the input signal, the phase shift introduced at the center of the resonance spectrum is changed. The tunable phase shift at the resonance wavelength can be used to implement a tunable FHT. A germanium-doped SOS MRR with a high-index contrast of 3.8% is fabricated. The use of the fabricated MRR for the implementation of a tunable FHT with tunable orders at 1, 0.85, 0.95, 1.05, and 1.13 for a Gaussian pulse with the temporal full width at half-maximum of 80 ps is experimentally demonstrated.

High-power, fixed, and tunable wavelength, grating-free cascaded Raman fiber lasers

NASA Astrophysics Data System (ADS)

Balaswamy, V.; Arun, S.; Aparanji, Santosh; Choudhury, Vishal; Supradeepa, V. R.

2018-04-01

Cascaded Raman lasers enable high powers at various wavelength bands inaccessible with conventional rare-earth doped lasers. The input and output wavelengths of conventional implementations are fixed by the constituent fiber gratings necessary for cascaded Raman conversion. We demonstrate here, a simple architecture for high power, fixed and wavelength tunable, grating-free, cascaded Raman conversion between different wavelength bands. The architecture is based on the recently proposed distributed feedback Raman lasers. Here, we implement a module which converts the Ytterbium band to the eye-safe 1.5micron region. We demonstrate pump-limited output powers of over 30W in fixed and continuously wavelength tunable configurations.

The value of continuity: Refined isogeometric analysis and fast direct solvers

DOE PAGES

Garcia, Daniel; Pardo, David; Dalcin, Lisandro; ...

2016-08-24

Here, we propose the use of highly continuous finite element spaces interconnected with low continuity hyperplanes to maximize the performance of direct solvers. Starting from a highly continuous Isogeometric Analysis (IGA) discretization, we introduce C0-separators to reduce the interconnection between degrees of freedom in the mesh. By doing so, both the solution time and best approximation errors are simultaneously improved. We call the resulting method “refined Isogeometric Analysis (rIGA)”. To illustrate the impact of the continuity reduction, we analyze the number of Floating Point Operations (FLOPs), computational times, and memory required to solve the linear system obtained by discretizing themore » Laplace problem with structured meshes and uniform polynomial orders. Theoretical estimates demonstrate that an optimal continuity reduction may decrease the total computational time by a factor between p 2 and p 3, with pp being the polynomial order of the discretization. Numerical results indicate that our proposed refined isogeometric analysis delivers a speed-up factor proportional to p 2. In a 2D mesh with four million elements and p=5, the linear system resulting from rIGA is solved 22 times faster than the one from highly continuous IGA. In a 3D mesh with one million elements and p=3, the linear system is solved 15 times faster for the refined than the maximum continuity isogeometric analysis.« less

Low-Cost Space Hardware and Software

NASA Technical Reports Server (NTRS)

Shea, Bradley Franklin

2013-01-01

The goal of this project is to demonstrate and support the overall vision of NASA's Rocket University (RocketU) through the design of an electrical power system (EPS) monitor for implementation on RUBICS (Rocket University Broad Initiatives CubeSat), through the support for the CHREC (Center for High-Performance Reconfigurable Computing) Space Processor, and through FPGA (Field Programmable Gate Array) design. RocketU will continue to provide low-cost innovations even with continuous cuts to the budget.

Increases in Parent Attendance to Behavioral Parent Training Due to Concurrent Child Treatment Groups

ERIC Educational Resources Information Center

Jensen, Scott A.; Grimes, Lisa K.

2010-01-01

Though behavioral parent training has been demonstrated to be an effective intervention for child behavior problems, it continues to suffer from high attrition rates. Few variables have been found to predict or decrease high attrition rates from parent training classes. The present study found 43-52% increases in attendance rates for parents whose…

Multilength Scale Patterning of Functional Layers by Roll-to-Roll Ultraviolet-Light-Assisted Nanoimprint Lithography.

PubMed

Leitgeb, Markus; Nees, Dieter; Ruttloff, Stephan; Palfinger, Ursula; Götz, Johannes; Liska, Robert; Belegratis, Maria R; Stadlober, Barbara

2016-05-24

Top-down fabrication of nanostructures with high throughput is still a challenge. We demonstrate the fast (>10 m/min) and continuous fabrication of multilength scale structures by roll-to-roll UV-nanoimprint lithography on a 250 mm wide web. The large-area nanopatterning is enabled by a multicomponent UV-curable resist system (JRcure) with viscous, mechanical, and surface properties that are tunable over a wide range to either allow for usage as polymer stamp material or as imprint resist. The adjustable elasticity and surface chemistry of the resist system enable multistep self-replication of structured resist layers. Decisive for defect-free UV-nanoimprinting in roll-to-roll is the minimization of the surface energies of stamp and resist, and the stepwise reduction of the stiffness from one layer to the next is essential for optimizing the reproduction fidelity especially for nanoscale features. Accordingly, we demonstrate the continuous replication of 3D nanostructures and the high-throughput fabrication of multilength scale resist structures resulting in flexible polyethylenetherephtalate film rolls with superhydrophobic properties. Moreover, a water-soluble UV-imprint resist (JRlift) is introduced that enables residue-free nanoimprinting in roll-to-roll. Thereby we could demonstrate high-throughput fabrication of metallic patterns with only 200 nm line width.

Using standardized patient encounters to teach longitudinal continuity of care in a family medicine clerkship.

PubMed

Vest, Bonnie M; Lynch, Abigail; McGuigan, Denise; Servoss, Timothy; Zinnerstrom, Karen; Symons, Andrew B

2016-08-17

Despite demonstrated benefits of continuity of care, longitudinal care experiences are difficult to provide to medical students. A series of standardized patient encounters was developed as an innovative curricular element to address this gap in training for medical students in a family medicine clerkship. The objective of this paper is to describe the development and implementation of the curriculum, evaluate the effectiveness of the curriculum for increasing student confidence around continuity of care and chronic disease management, and explore student opinions of the value of the experience. The encounters simulate continuity of care in typical family medicine practice over four standardized patient visits, providing students with experience in longitudinal relationships, ongoing management of chronic and acute conditions, lifestyle counseling, and the use of an electronic medical record. Perceptions of the curriculum were obtained using a pre-post survey asking students to self-rate experience and confidence in continuity relationships, chronic disease management, and lifestyle counseling. Students were also asked about the overall effectiveness of the encounters for simulating family practice and continuity of care. Open-ended comments were gathered through weekly reflection papers submitted by the students. Of 138 third-year medical students, 137 completed the pre-survey, 126 completed the post-survey, and 125 (91%) completed both the pre- and the post-survey. Evaluation results demonstrated that students highly valued the experience. Complete confidence data for 116 students demonstrated increased confidence pre-post (t(115) = 14.92, p < .001) in managing chronic disease and establishing relationships. Open-ended comments reflected how the experience fostered appreciation for the significance of patient-doctor relationships and continuity of care. This curriculum offers a promising approach to providing students with continuity of care experience. The model addresses a general lack of training in continuity of care in medical schools and provides a standardized method for teaching chronic disease management and continuity relationships.

40 CFR 63.1975 - How do I calculate the 3-hour block average used to demonstrate compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Waste Landfills General and Continuing Compliance Requirements § 63.1975 How do I calculate the 3-hour... subpart: (a) Monitoring system breakdowns, repairs, calibration checks, and zero (low-level) and high...

Continuous monitoring of blood volume changes in humans

NASA Technical Reports Server (NTRS)

Hinghofer-Szalkay, H.; Greenleaf, J. E.

1987-01-01

Use of on-line high-precision mass densitometry for the continuous monitoring of blood volume changes in humans was demonstrated by recording short-term blood volume alterations produced by changes in body position. The mass density of antecubital venous blood was measured continuously for 80 min per session with 0.1 g/l precision at a flow rate of 1.5 ml/min. Additional discrete plasma density and hematocrit measurements gave linear relations between all possible combinations of blood density, plasma density, and hematocrit. Transient filtration phenomena were revealed that are not amenable to discontinuous measurements.

40 CFR 63.6003 - How do I monitor and collect data to demonstrate continuous compliance with the emission limits...

Code of Federal Regulations, 2010 CFR

2010-07-01

... demonstrate continuous compliance with the emission limits for tire production affected sources? 63.6003... Standards for Hazardous Air Pollutants: Rubber Tire Manufacturing Continuous Compliance Requirements for Tire Production Affected Sources § 63.6003 How do I monitor and collect data to demonstrate continuous...

Generation of continuously rotating polarization by combining cross-polarizations and its application in surface structuring.

PubMed

Lam, Billy; Zhang, Jihua; Guo, Chunlei

2017-08-01

In this study, we develop a simple but highly effective technique that generates a continuously varying polarization within a laser beam. This is achieved by having orthogonal linear polarizations on each side of the beam. By simply focusing such a laser beam, we can attain a gradually and continuously changing polarization within the entire Rayleigh range due to diffraction. To demonstrate this polarization distribution, we apply this laser beam onto a metal surface and create a continuously rotating laser induced periodic surface structure pattern. This technique provides a very effective way to produce complex surface structures that may potentially find applications, such as polarization modulators and metasurfaces.

Overview of ERA Integrated Technology Demonstration (ITD) 51A Ultra-High Bypass (UHB) Integration for Hybrid Wing Body (HWB)

NASA Technical Reports Server (NTRS)

Flamm, Jeffrey D.; James, Kevin D.; Bonet, John T.

2016-01-01

The NASA Environmentally Responsible Aircraft Project (ERA) was a ve year project broken into two phases. In phase II, high N+2 Technical Readiness Level demonstrations were grouped into Integrated Technology Demonstrations (ITD). This paper describes the work done on ITD-51A: the Vehicle Systems Integration, Engine Airframe Integration Demonstration. Refinement of a Hybrid Wing Body (HWB) aircraft from the possible candidates developed in ERA Phase I was continued. Scaled powered, and unpowered wind- tunnel testing, with and without acoustics, in the NASA LARC 14- by 22-foot Subsonic Tunnel, the NASA ARC Unitary Plan Wind Tunnel, and the 40- by 80-foot test section of the National Full-Scale Aerodynamics Complex (NFAC) in conjunction with very closely coupled Computational Fluid Dynamics was used to demonstrate the fuel burn and acoustic milestone targets of the ERA Project.

Overview of the Development and Mission Application of the Advanced Electric Propulsion System (AEPS)

NASA Technical Reports Server (NTRS)

Herman, Daniel A.; Tofil, Todd; Santiago, Walter; Kamhawi, Hani; Polk, James E.; Snyder, John Steven; Hofer, Richard R.; Picha, Frank; Jackson, Jerry; Allen, May

2017-01-01

NASA remains committed to the development and demonstration of a high-power solar electric propulsion capability for the Agency. NASA is continuing to develop the 14 kilowatt Advanced Electric Propulsion System (AEPS), which has recently completed an Early Integrated System Test and System Preliminary Design Review. NASA continues to pursue Solar Electric Propulsion (SEP) Technology Demonstration Mission partners and mature high-power SEP mission concepts. The recent announcement of the development of a Power and Propulsion Element (PPE) as the first element of an evolvable human architecture to Mars has replaced the Asteroid Redirect Robotic Mission as the most probable first application of the AEPS Hall thruster system. This high-power SEP capability, or an extensible derivative of it, has been identified as a critical part of an affordable, beyond-low-Earth-orbit, manned-exploration architecture. This paper presents the status of the combined NASA and Aerojet AEPS development activities and updated mission concept for implementation of the AEPS hardware as part of the ion propulsion system for a PPE.

Overview of the Development and Mission Application of the Advanced Electric Propulsion System (AEPS)

NASA Technical Reports Server (NTRS)

Herman, Daniel A.; Tofil, Todd A.; Santiago, Walter; Kamhawi, Hani; Polk, James E.; Snyder, John S.; Hofer, Richard R.; Picha, Frank Q.; Jackson, Jerry; Allen, May

2018-01-01

NASA remains committed to the development and demonstration of a high-power solar electric propulsion capability for the Agency. NASA is continuing to develop the 14 kW Advanced Electric Propulsion System (AEPS), which has recently completed an Early Integrated System Test and System Preliminary Design Review. NASA continues to pursue Solar Electric Propulsion (SEP) Technology Demonstration Mission partners and mature high-power SEP mission concepts. The recent announcement of the development of a Power and Propulsion Element (PPE) as the first element of an evolvable human architecture to Mars has replaced the Asteroid Redirect Robotic Mission (ARRM) as the most probable first application of the AEPS Hall thruster system. This high-power SEP capability, or an extensible derivative of it, has been identified as a critical part of an affordable, beyond-low-Earth-orbit, manned exploration architecture. This paper presents the status of the combined NASA and Aerojet Rocketdyne AEPS development activities and updated mission concept for implementation of the AEPS hardware as part of the ion propulsion system for a PPE.

High-repetition-rate interferometric Rayleigh scattering for flow-velocity measurements

NASA Astrophysics Data System (ADS)

Estevadeordal, Jordi; Jiang, Naibo; Cutler, Andrew D.; Felver, Josef J.; Slipchenko, Mikhail N.; Danehy, Paul M.; Gord, James R.; Roy, Sukesh

2018-03-01

High-repetition-rate interferometric-Rayleigh-scattering (IRS) velocimetry is demonstrated for non-intrusive, high-speed flow-velocity measurements. High temporal resolution is obtained with a quasi-continuous burst-mode laser that is capable of operating at 10-100 kHz, providing 10-ms bursts with pulse widths of 5-1000 ns and pulse energy > 100 mJ at 532 nm. Coupled with a high-speed camera system, the IRS method is based on imaging the flow field through an etalon with 8-GHz free spectral range and capturing the Doppler shift of the Rayleigh-scattered light from the flow at multiple points having constructive interference. The seed-laser linewidth permits a laser linewidth of < 150 MHz at 532 nm. The technique is demonstrated in a high-speed jet, and high-repetition-rate image sequences are shown.

Nurse Continuity and Hospital-Acquired Pressure Ulcers: A Comparative Analysis Using an Electronic Health Record "Big Data" Set.

PubMed

Stifter, Janet; Yao, Yingwei; Lodhi, Muhammad Kamran; Lopez, Karen Dunn; Khokhar, Ashfaq; Wilkie, Diana J; Keenan, Gail M

2015-01-01

Little research demonstrating the association between nurse continuity and patient outcomes exists despite an intuitive belief that continuity makes a difference in care outcomes. The aim of this study was to examine the association of nurse continuity with the prevention of hospital-acquired pressure ulcers (HAPU). A secondary use of data from the Hands on Automated Nursing Data System (HANDS) was performed for this comparative study. The HANDS is a nursing plan of care data set containing 42,403 episodes documented by 787 nurses, on nine units, in four hospitals and includes nurse staffing and patient characteristics. The HANDS data set resides in a "big data" relational database consisting of 89 tables and 747 columns of data. Via data mining, we created an analytic data set of 840 care episodes, 210 with and 630 without HAPUs, matched by nursing unit, patient age, and patient characteristics. Logistic regression analysis determined the association of nurse continuity and additional nurse-staffing variables on HAPU occurrence. Poor nurse continuity (unit mean continuity index = .21-.42 [1.0 = optimal continuity]) was noted on all nine study units. Nutrition, mobility, perfusion, hydration, and skin problems on admission, as well as patient age, were associated with HAPUs (p < .001). Controlling for patient characteristics, nurse continuity, and the interactions between nurse continuity and other nurse-staffing variables were not significantly associated with HAPU development. Patient characteristics including nutrition, mobility, and perfusion were associated with HAPUs, but nurse continuity was not. We demonstrated a high level of variation in the degree of continuity between patient episodes in the HANDS data, showing that it offers rich potential for future study of nurse continuity and its effect on patient outcomes.

The influence of ripening temperature on ‘Hass’ fruit quality

USDA-ARS?s Scientific Manuscript database

Previous research demonstrated the importance of temperature management during avocado (Persea americana Mill) fruit ripening; however this work was focused on maintaining the fruit at elevated temperatures continuously during the ripening process. We examined the influence of short duration high t...

High-resolution multiphoton microscopy with a low-power continuous wave laser pump.

PubMed

Chen, Xiang-Dong; Li, Shen; Du, Bo; Dong, Yang; Wang, Ze-Hao; Guo, Guang-Can; Sun, Fang-Wen

2018-02-15

Multiphoton microscopy (MPM) has been widely used for three-dimensional biological imaging. Here, based on the photon-induced charge state conversion process, we demonstrated a low-power high-resolution MPM with a nitrogen vacancy (NV) center in diamond. Continuous wave green and orange lasers were used to pump and detect the two-photon charge state conversion, respectively. The power of the laser for multiphoton excitation was 40 μW. Both the axial and lateral resolutions were improved approximately 1.5 times compared with confocal microscopy. The results can be used to improve the resolution of the NV center-based quantum sensing and biological imaging.

Effects of space environment on composites: An analytical study of critical experimental parameters

NASA Technical Reports Server (NTRS)

Gupta, A.; Carroll, W. F.; Moacanin, J.

1979-01-01

A generalized methodology currently employed at JPL, was used to develop an analytical model for effects of high-energy electrons and interactions between electron and ultraviolet effects. Chemical kinetic concepts were applied in defining quantifiable parameters; the need for determining short-lived transient species and their concentration was demonstrated. The results demonstrates a systematic and cost-effective means of addressing the issues and show qualitative and quantitative, applicable relationships between space radiation and simulation parameters. An equally important result is identification of critical initial experiments necessary to further clarify the relationships. Topics discussed include facility and test design; rastered vs. diffuse continuous e-beam; valid acceleration level; simultaneous vs. sequential exposure to different types of radiation; and interruption of test continuity.

Monolayer graphene-insulator-semiconductor emitter for large-area electron lithography

NASA Astrophysics Data System (ADS)

Kirley, Matthew P.; Aloui, Tanouir; Glass, Jeffrey T.

2017-06-01

The rapid adoption of nanotechnology in fields as varied as semiconductors, energy, and medicine requires the continual improvement of nanopatterning tools. Lithography is central to this evolving nanotechnology landscape, but current production systems are subject to high costs, low throughput, or low resolution. Herein, we present a solution to these problems with the use of monolayer graphene in a graphene-insulator-semiconductor (GIS) electron emitter device for large-area electron lithography. Our GIS device displayed high emission efficiency (up to 13%) and transferred large patterns (500 × 500 μm) with high fidelity (<50% spread). The performance of our device demonstrates a feasible path to dramatic improvements in lithographic patterning systems, enabling continued progress in existing industries and opening opportunities in nanomanufacturing.

Stress Measurements on Blair High School Gymnasium: A Demonstration of Space Technology Transfer

NASA Technical Reports Server (NTRS)

Kastel, Dean

1966-01-01

This Report describes an actual demonstration of transfer to non-space use of technologies developed for space programs applications. Techniques used in assessing static and dynamic characteristics of the Blair High School gymnasium involved data acquisition by continuous scanning of strain gauge data acquired over a time of wide-temperature range, and analysis by a computer routine developed by Jet Propulsion Laboratory five years ago. The advantage of this method over conventional structural testing of uniquely designed structures was proved. More importantly, the process of demonstration was shown to be of great assistance to, and extension of, normal methods of disseminating information of new technologies. It is felt that significant benefit will derive from this improved mode oi concept transfer.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jahnke, Fred C.

FuelCell Energy and ACuPowder investigated and demonstrated the use of waste anode exhaust gas from a high temperature fuel cell for replacing the reducing gas in a metal processing furnace. Currently companies purchase high pressure or liquefied gases for the reducing gas which requires substantial energy in production, compression/liquefaction, and transportation, all of which is eliminated by on-site use of anode exhaust gas as reducing gas. We performed research on the impact of the gas composition on product quality and then demonstrated at FuelCell Energy’s manufacturing facility in Torrington, Connecticut. This demonstration project continues to operate even though the researchmore » program is completed as it provides substantial benefits to the manufacturing facility by supplying power, heat, and hydrogen.« less

High-power, fixed, and tunable wavelength, grating-free cascaded Raman fiber lasers.

PubMed

Balaswamy, V; Arun, S; Aparanji, Santosh; Choudhury, Vishal; Supradeepa, V R

2018-04-01

Cascaded Raman lasers enable high powers at various wavelength bands inaccessible with conventional rare-earth-doped lasers. The input and output wavelengths of conventional implementations are fixed by the constituent fiber gratings necessary for cascaded Raman conversion. We demonstrate here a simple architecture for high-power, fixed, and wavelength tunable, grating-free, cascaded Raman conversion between different wavelength bands. The architecture is based on the recently proposed distributed feedback Raman lasers. Here, we implement a module which converts the ytterbium band to the eye-safe 1.5 μm region. We demonstrate pump-limited output powers of over 30 W in fixed and continuously wavelength tunable configurations.

Mechanical design and fabrication of the VHF-gun, the Berkeley normal-conducting continuous-wave high-brightness electron source

NASA Astrophysics Data System (ADS)

Wells, R. P.; Ghiorso, W.; Staples, J.; Huang, T. M.; Sannibale, F.; Kramasz, T. D.

2016-02-01

A high repetition rate, MHz-class, high-brightness electron source is a key element in future high-repetition-rate x-ray free electron laser-based light sources. The VHF-gun, a novel low frequency radio-frequency gun, is the Lawrence Berkeley National Laboratory (LBNL) response to that need. The gun design is based on a normal conducting, single cell cavity resonating at 186 MHz in the VHF band and capable of continuous wave operation while still delivering the high accelerating fields at the cathode required for the high brightness performance. The VHF-gun was fabricated and successfully commissioned in the framework of the Advanced Photo-injector EXperiment, an injector built at LBNL to demonstrate the capability of the gun to deliver the required beam quality. The basis for the selection of the VHF-gun technology, novel design features, and fabrication techniques are described.

Mechanical design and fabrication of the VHF-gun, the Berkeley normal-conducting continuous-wave high-brightness electron source.

PubMed

Wells, R P; Ghiorso, W; Staples, J; Huang, T M; Sannibale, F; Kramasz, T D

2016-02-01

A high repetition rate, MHz-class, high-brightness electron source is a key element in future high-repetition-rate x-ray free electron laser-based light sources. The VHF-gun, a novel low frequency radio-frequency gun, is the Lawrence Berkeley National Laboratory (LBNL) response to that need. The gun design is based on a normal conducting, single cell cavity resonating at 186 MHz in the VHF band and capable of continuous wave operation while still delivering the high accelerating fields at the cathode required for the high brightness performance. The VHF-gun was fabricated and successfully commissioned in the framework of the Advanced Photo-injector EXperiment, an injector built at LBNL to demonstrate the capability of the gun to deliver the required beam quality. The basis for the selection of the VHF-gun technology, novel design features, and fabrication techniques are described.

45 CFR 260.76 - What special rules apply to States that are continuing evaluations of their waiver demonstrations?

Code of Federal Regulations, 2011 CFR

2011-10-01

... demonstrations? If a State is continuing research that employs an experimental design in order to complete an impact evaluation of a waiver demonstration, the experimental and control groups may continue to be...

45 CFR 260.76 - What special rules apply to States that are continuing evaluations of their waiver demonstrations?

Code of Federal Regulations, 2010 CFR

2010-10-01

... demonstrations? If a State is continuing research that employs an experimental design in order to complete an impact evaluation of a waiver demonstration, the experimental and control groups may continue to be...

45 CFR 260.76 - What special rules apply to States that are continuing evaluations of their waiver demonstrations?

Code of Federal Regulations, 2012 CFR

2012-10-01

... demonstrations? If a State is continuing research that employs an experimental design in order to complete an impact evaluation of a waiver demonstration, the experimental and control groups may continue to be...

A Comparison of Approaches to Detect Deception

DTIC Science & Technology

2010-12-30

blood pressure has been demonstrated for this instrument (Fortin et al., 2006; Sackl- Pietsch , 2010). A sampling rate of 62.5 Hz is considerably...Psychophysiology, 15, 344-359. Sackl- Pietsch , E. (2010). Continuous non-invasive arterial pressure shows high accuracy in comparison to invasive intra-arterial

High-yield cell-free synthesis of human EGFR by IRES-mediated protein translation in a continuous exchange cell-free reaction format

PubMed Central

Quast, Robert B.; Sonnabend, Andrei; Stech, Marlitt; Wüstenhagen, Doreen A.; Kubick, Stefan

2016-01-01

Cell-free protein synthesis systems derived from eukaryotic sources often provide comparatively low amounts of several μg per ml of de novo synthesized membrane protein. In order to overcome this, we herein demonstrate the high-yield cell-free synthesis of the human EGFR in a microsome-containing system derived from cultured Sf21 cells. Yields were increased more than 100-fold to more than 285 μg/ml by combination of IRES-mediated protein translation with a continuous exchange cell-free reaction format that allowed for prolonged reaction lifetimes exceeding 24 hours. In addition, an orthogonal cell-free translation system is presented that enabled the site-directed incorporation of p-Azido-L-phenylalanine by amber suppression. Functionality of cell-free synthesized receptor molecules is demonstrated by investigation of autophosphorylation activity in the absence of ligand and interaction with the cell-free synthesized adapter molecule Grb2. PMID:27456041

In situ hydrogen utilization for high fraction acetate production in mixed culture hollow-fiber membrane biofilm reactor.

PubMed

Zhang, Fang; Ding, Jing; Shen, Nan; Zhang, Yan; Ding, Zhaowei; Dai, Kun; Zeng, Raymond J

2013-12-01

Syngas fermentation is a promising route for resource recovery. Acetate is an important industrial chemical product and also an attractive precursor for liquid biofuels production. This study demonstrated high fraction acetate production from syngas (H₂ and CO₂) in a hollow-fiber membrane biofilm reactor, in which the hydrogen utilizing efficiency reached 100% during the operational period. The maximum concentration of acetate in batch mode was 12.5 g/L, while the acetate concentration in continuous mode with a hydraulic retention time of 9 days was 3.6 ± 0.1 g/L. Since butyrate concentration was rather low and below 0.1 g/L, the acetate fraction was higher than 99% in both batch and continuous modes. Microbial community analysis showed that the biofilm was dominated by Clostridium spp., such as Clostridium ljungdahlii and Clostridium drakei, the percentage of which was 70.5%. This study demonstrates a potential technology for the in situ utilization of syngas and valuable chemical production.

A Y-chromosome STR marker should be added to commercial multiplex STR kits.

PubMed

Oz, Carla; Zaken, Neomi; Amiel, Merav; Zamir, Ashira

2008-07-01

Autosomal short tandem repeat (STR) analysis has become highly relevant in the identification of victims from mass disasters and terrorist attacks. In such events, gender misidentification can be of grave consequences, yet the list reporting amelogenin amplification failure using STR multiplex kits continues to grow. Presented here are three such examples. In the first case, we present two male suspects who demonstrated amelogenin Y-deficient results using two commercial kit procedures. The presence of their Y chromosomes was proven by obtaining a Y-haplotype. The second case demonstrated a profile from a third male suspect where only the Y homolog of the XY pair was amplified. In events such as mass disasters or terrorist attacks, timely and reliable high throughput DNA typing results are essential. As the number of reported cases of amplification failure at the amelogenin gene continues to grow, we suggest that the incorporation of a better gender identification tool in commercial kits is crucial.

40 CFR 63.7121 - How do I demonstrate continuous compliance with the emission limitations standard?

Code of Federal Regulations, 2012 CFR

2012-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Lime Manufacturing Plants Continuous Compliance Requirements § 63.7121 How do I demonstrate...

40 CFR 63.7121 - How do I demonstrate continuous compliance with the emission limitations standard?

Code of Federal Regulations, 2014 CFR

2014-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Lime Manufacturing Plants Continuous Compliance Requirements § 63.7121 How do I demonstrate...

40 CFR 63.7121 - How do I demonstrate continuous compliance with the emission limitations standard?

Code of Federal Regulations, 2011 CFR

2011-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Lime Manufacturing Plants Continuous Compliance Requirements § 63.7121 How do I demonstrate...

40 CFR 63.7121 - How do I demonstrate continuous compliance with the emission limitations standard?

Code of Federal Regulations, 2013 CFR

2013-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Lime Manufacturing Plants Continuous Compliance Requirements § 63.7121 How do I demonstrate...

40 CFR 63.7922 - How do I demonstrate continuous compliance with the work practice standards for equipment leaks?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS... Hazardous Air Pollutants: Site Remediation Equipment Leaks § 63.7922 How do I demonstrate continuous...

40 CFR 63.7922 - How do I demonstrate continuous compliance with the work practice standards for equipment leaks?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS... Hazardous Air Pollutants: Site Remediation Equipment Leaks § 63.7922 How do I demonstrate continuous...

40 CFR 63.7922 - How do I demonstrate continuous compliance with the work practice standards for equipment leaks?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS... Hazardous Air Pollutants: Site Remediation Equipment Leaks § 63.7922 How do I demonstrate continuous...

40 CFR 63.7922 - How do I demonstrate continuous compliance with the work practice standards for equipment leaks?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS... Hazardous Air Pollutants: Site Remediation Equipment Leaks § 63.7922 How do I demonstrate continuous...

40 CFR 63.7922 - How do I demonstrate continuous compliance with the work practice standards for equipment leaks?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS... Hazardous Air Pollutants: Site Remediation Equipment Leaks § 63.7922 How do I demonstrate continuous...

Continuous manufacturing of solid lipid nanoparticles by hot melt extrusion.

PubMed

Patil, Hemlata; Kulkarni, Vijay; Majumdar, Soumyajit; Repka, Michael A

2014-08-25

Solid lipid nanoparticles (SLN) can either be produced by hot homogenization of melted lipids at higher temperatures or by a cold homogenization process. This paper proposes and demonstrates the formulation of SLN for pharmaceutical applications by combining two processes: hot melt extrusion (HME) technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. This work aimed at developing continuous and scalable processes for SLN by mixing a lipid and aqueous phase containing an emulsifier in the extruder barrel at temperatures above the melting point of the lipid and further reducing the particle size of emulsion by HPH linked to HME in a sequence. The developed novel platform demonstrated better process control and size reduction compared to the conventional process of hot homogenization (batch process). Varying the process parameters enabled the production of SLN below 200 nm (for 60 mg/ml lipid solution at a flow rate of 100ml/min). Among the several process parameters investigated, the lipid concentration, residence time and screw design played major roles in influencing the size of the SLN. This new process demonstrates the potential use of hot melt extrusion technology for continuous and large-scale production of SLN. Copyright © 2014 Elsevier B.V. All rights reserved.

Mechanically stable, hierarchically porous Cu3(btc)2 (HKUST-1) monoliths via direct conversion of copper(II) hydroxide-based monoliths.

PubMed

Moitra, Nirmalya; Fukumoto, Shotaro; Reboul, Julien; Sumida, Kenji; Zhu, Yang; Nakanishi, Kazuki; Furukawa, Shuhei; Kitagawa, Susumu; Kanamori, Kazuyoshi

2015-02-28

The synthesis of highly crystalline macro-meso-microporous monolithic Cu3(btc)2 (HKUST-1; btc(3-) = benzene-1,3,5-tricarboxylate) is demonstrated by direct conversion of Cu(OH)2-based monoliths while preserving the characteristic macroporous structure. The high mechanical strength of the monoliths is promising for possible applications to continuous flow reactors.

A Demonstration of the Continuous Phase (Second-Order) Transition of a Binary Liquid System in the Region around Its Critical Point

ERIC Educational Resources Information Center

Johnson, Michael R.

2006-01-01

In most general chemistry and introductory physical chemistry classes, critical point is defined as that temperature-pressure point on a phase diagram where the liquid-gas interface disappears, a phenomenon that generally occurs at relatively high temperatures or high pressures. Two examples are: water, with a critical point at 647 K (critical…

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations.

PubMed

Toh, Ren Wei; Li, Jie Sheng; Wu, Jie

2018-01-04

A new reaction screening technology for organic synthesis was recently demonstrated by combining elements from both continuous micro-flow and conventional batch reactors, coined stop-flow micro-tubing (SFMT) reactors. In SFMT, chemical reactions that require high pressure can be screened in parallel through a safer and convenient way. Cross-contamination, which is a common problem in reaction screening for continuous flow reactors, is avoided in SFMT. Moreover, the commercially available light-permeable micro-tubing can be incorporated into SFMT, serving as an excellent choice for light-mediated reactions due to a more effective uniform light exposure, compared to batch reactors. Overall, the SFMT reactor system is similar to continuous flow reactors and more superior than batch reactors for reactions that incorporate gas reagents and/or require light-illumination, which enables a simple but highly efficient reaction screening system. Furthermore, any successfully developed reaction in the SFMT reactor system can be conveniently translated to continuous-flow synthesis for large scale production.

Continuous flow real-time PCR device using multi-channel fluorescence excitation and detection.

PubMed

Hatch, Andrew C; Ray, Tathagata; Lintecum, Kelly; Youngbull, Cody

2014-02-07

High throughput automation is greatly enhanced using techniques that employ conveyor belt strategies with un-interrupted streams of flow. We have developed a 'conveyor belt' analog for high throughput real-time quantitative Polymerase Chain Reaction (qPCR) using droplet emulsion technology. We developed a low power, portable device that employs LED and fiber optic fluorescence excitation in conjunction with a continuous flow thermal cycler to achieve multi-channel fluorescence detection for real-time fluorescence measurements. Continuously streaming fluid plugs or droplets pass through tubing wrapped around a two-temperature zone thermal block with each wrap of tubing fluorescently coupled to a 64-channel multi-anode PMT. This work demonstrates real-time qPCR of 0.1-10 μL droplets or fluid plugs over a range of 7 orders of magnitude concentration from 1 × 10(1) to 1 × 10(7). The real-time qPCR analysis allows dynamic range quantification as high as 1 × 10(7) copies per 10 μL reaction, with PCR efficiencies within the range of 90-110% based on serial dilution assays and a limit of detection of 10 copies per rxn. The combined functionality of continuous flow, low power thermal cycling, high throughput sample processing, and real-time qPCR improves the rates at which biological or environmental samples can be continuously sampled and analyzed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Donald F.; Schulz, Carl; Konijnenburg, Marco

High-resolution Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry imaging enables the spatial mapping and identification of biomolecules from complex surfaces. The need for long time-domain transients, and thus large raw file sizes, results in a large amount of raw data (“big data”) that must be processed efficiently and rapidly. This can be compounded by largearea imaging and/or high spatial resolution imaging. For FT-ICR, data processing and data reduction must not compromise the high mass resolution afforded by the mass spectrometer. The continuous mode “Mosaic Datacube” approach allows high mass resolution visualization (0.001 Da) of mass spectrometry imaging data, butmore » requires additional processing as compared to featurebased processing. We describe the use of distributed computing for processing of FT-ICR MS imaging datasets with generation of continuous mode Mosaic Datacubes for high mass resolution visualization. An eight-fold improvement in processing time is demonstrated using a Dutch nationally available cloud service.« less

Terahertz quantum-cascade lasers as high-power and wideband, gapless sources for spectroscopy.

PubMed

Röben, Benjamin; Lü, Xiang; Hempel, Martin; Biermann, Klaus; Schrottke, Lutz; Grahn, Holger T

2017-07-10

Terahertz (THz) quantum-cascade lasers (QCLs) are powerful radiation sources for high-resolution and high-sensitivity spectroscopy with a discrete spectrum between 2 and 5 THz as well as a continuous coverage of several GHz. However, for many applications, a radiation source with a continuous coverage of a substantially larger frequency range is required. We employed a multi-mode THz QCL operated with a fast ramped injection current, which leads to a collective tuning of equally-spaced Fabry-Pérot laser modes exceeding their separation. A continuous coverage over 72 GHz at about 4.7 THz was achieved. We demonstrate that the QCL is superior to conventional sources used in Fourier transform infrared spectroscopy in terms of the signal-to-noise ratio as well as the dynamic range by one to two orders of magnitude. Our results pave the way for versatile THz spectroscopic systems with unprecedented resolution and sensitivity across a wide frequency range.

Broadband optical equalizer using fault tolerant digital micromirrors.

PubMed

Riza, Nabeel; Mughal, M Junaid

2003-06-30

For the first time, the design and demonstration of a near continuous spectral processing mode broadband equalizer is described using the earlier proposed macro-pixel spatial approach for multiwavelength fiber-optic attenuation in combination with a high spectral resolution broadband transmissive volume Bragg grating. The demonstrated design features low loss and low polarization dependent loss with broadband operation. Such an analog mode spectral processor can impact optical applications ranging from test and instrumentation to dynamic alloptical networks.

10 CFR 73.20 - General performance objective and requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... availability of the physical protection system, including a demonstration that any defects of such activities... Section 73.20 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS... arrangements for a physical protection system which will have as its objective to provide high assurance that...

SPATIAL PATTERNS OF WATER QUALITY AND PLANKTON FROM HIGH-RESOLUTION CONTINUOUS IN SITU SENSING ALONG A 537-KM NEARSHORE TRANSECT OF WESTERN LAKE SUPERIOR, 2004

EPA Science Inventory

A demonstration that the adaptation of electronic instrumentation and towed survey strategies are effective in providing rapid, spatially extensive, and cost effective data for assessment of the Great Lakes.

Maximizing and stabilizing luminescence from halide perovskites with potassium passivation

NASA Astrophysics Data System (ADS)

Abdi-Jalebi, Mojtaba; Andaji-Garmaroudi, Zahra; Cacovich, Stefania; Stavrakas, Camille; Philippe, Bertrand; Richter, Johannes M.; Alsari, Mejd; Booker, Edward P.; Hutter, Eline M.; Pearson, Andrew J.; Lilliu, Samuele; Savenije, Tom J.; Rensmo, Håkan; Divitini, Giorgio; Ducati, Caterina; Friend, Richard H.; Stranks, Samuel D.

2018-03-01

Metal halide perovskites are of great interest for various high-performance optoelectronic applications. The ability to tune the perovskite bandgap continuously by modifying the chemical composition opens up applications for perovskites as coloured emitters, in building-integrated photovoltaics, and as components of tandem photovoltaics to increase the power conversion efficiency. Nevertheless, performance is limited by non-radiative losses, with luminescence yields in state-of-the-art perovskite solar cells still far from 100 per cent under standard solar illumination conditions. Furthermore, in mixed halide perovskite systems designed for continuous bandgap tunability (bandgaps of approximately 1.7 to 1.9 electronvolts), photoinduced ion segregation leads to bandgap instabilities. Here we demonstrate substantial mitigation of both non-radiative losses and photoinduced ion migration in perovskite films and interfaces by decorating the surfaces and grain boundaries with passivating potassium halide layers. We demonstrate external photoluminescence quantum yields of 66 per cent, which translate to internal yields that exceed 95 per cent. The high luminescence yields are achieved while maintaining high mobilities of more than 40 square centimetres per volt per second, providing the elusive combination of both high luminescence and excellent charge transport. When interfaced with electrodes in a solar cell device stack, the external luminescence yield—a quantity that must be maximized to obtain high efficiency—remains as high as 15 per cent, indicating very clean interfaces. We also demonstrate the inhibition of transient photoinduced ion-migration processes across a wide range of mixed halide perovskite bandgaps in materials that exhibit bandgap instabilities when unpassivated. We validate these results in fully operating solar cells. Our work represents an important advance in the construction of tunable metal halide perovskite films and interfaces that can approach the efficiency limits in tandem solar cells, coloured-light-emitting diodes and other optoelectronic applications.

Maximizing and stabilizing luminescence from halide perovskites with potassium passivation.

PubMed

Abdi-Jalebi, Mojtaba; Andaji-Garmaroudi, Zahra; Cacovich, Stefania; Stavrakas, Camille; Philippe, Bertrand; Richter, Johannes M; Alsari, Mejd; Booker, Edward P; Hutter, Eline M; Pearson, Andrew J; Lilliu, Samuele; Savenije, Tom J; Rensmo, Håkan; Divitini, Giorgio; Ducati, Caterina; Friend, Richard H; Stranks, Samuel D

2018-03-21

Metal halide perovskites are of great interest for various high-performance optoelectronic applications. The ability to tune the perovskite bandgap continuously by modifying the chemical composition opens up applications for perovskites as coloured emitters, in building-integrated photovoltaics, and as components of tandem photovoltaics to increase the power conversion efficiency. Nevertheless, performance is limited by non-radiative losses, with luminescence yields in state-of-the-art perovskite solar cells still far from 100 per cent under standard solar illumination conditions. Furthermore, in mixed halide perovskite systems designed for continuous bandgap tunability (bandgaps of approximately 1.7 to 1.9 electronvolts), photoinduced ion segregation leads to bandgap instabilities. Here we demonstrate substantial mitigation of both non-radiative losses and photoinduced ion migration in perovskite films and interfaces by decorating the surfaces and grain boundaries with passivating potassium halide layers. We demonstrate external photoluminescence quantum yields of 66 per cent, which translate to internal yields that exceed 95 per cent. The high luminescence yields are achieved while maintaining high mobilities of more than 40 square centimetres per volt per second, providing the elusive combination of both high luminescence and excellent charge transport. When interfaced with electrodes in a solar cell device stack, the external luminescence yield-a quantity that must be maximized to obtain high efficiency-remains as high as 15 per cent, indicating very clean interfaces. We also demonstrate the inhibition of transient photoinduced ion-migration processes across a wide range of mixed halide perovskite bandgaps in materials that exhibit bandgap instabilities when unpassivated. We validate these results in fully operating solar cells. Our work represents an important advance in the construction of tunable metal halide perovskite films and interfaces that can approach the efficiency limits in tandem solar cells, coloured-light-emitting diodes and other optoelectronic applications.

Pneumonitis: a serious adverse effect of PD-L1 inhibitors including pembrolizumab.

PubMed

Rickard, Frances; Hyams, Catherine; Low, Andrew T

2018-05-07

A 70-year-old man presented with breathlessness, cough and fever while receiving pembrolizumab for melanoma. A CT pulmonary angiogram demonstrated small bilateral upper lobe segmental pulmonary emboli with patchy ground-glass opacities and basal perilobular consolidation, in keeping with organising pneumonia. He was treated for community-acquired pneumonia and pulmonary emboli but rapidly deteriorated, with increasing hypoxia and dyspnoea. He was admitted to the intensive care unit for support with continuous positive airway pressure and high flow nasal oxygen. His clinical condition improved once he received high-dose intravenous methylprednisolone to treat pneumonitis. His treatment was continued with a weaning course of high-dose oral steroids, and he was discharged with a persistent oxygen requirement. The patient maintained a requirement for high doses of oral steroids and continued to deteriorate. He was referred to palliative care for symptom management and died a month following hospital discharge, as a result of pneumonitis due to pembrolizumab. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

High power disk lasers: advances and applications

NASA Astrophysics Data System (ADS)

Havrilla, David; Holzer, Marco

2011-02-01

Though the genesis of the disk laser concept dates to the early 90's, the disk laser continues to demonstrate the flexibility and the certain future of a breakthrough technology. On-going increases in power per disk, and improvements in beam quality and efficiency continue to validate the genius of the disk laser concept. As of today, the disk principle has not reached any fundamental limits regarding output power per disk or beam quality, and offers numerous advantages over other high power resonator concepts, especially over monolithic architectures. With well over 1000 high power disk lasers installations, the disk laser has proven to be a robust and reliable industrial tool. With advancements in running cost, investment cost and footprint, manufacturers continue to implement disk laser technology with more vigor than ever. This paper will explain important details of the TruDisk laser series and process relevant features of the system, like pump diode arrangement, resonator design and integrated beam guidance. In addition, advances in applications in the thick sheet area and very cost efficient high productivity applications like remote welding, remote cutting and cutting of thin sheets will be discussed.

76 FR 12081 - Notice of Two-Year Continuation of Disease Management Demonstration Project for TRICARE Standard...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-04

... Management Demonstration Project for TRICARE Standard Beneficiaries AGENCY: Department of Defense. ACTION: Notice of Two-Year Continuation of Disease Management Demonstration Project for TRICARE Standard... System (MHS) demonstration project entitled ``Disease Management Demonstration Project for TRICARE...

Development of Crystallizer for Advanced Aqueous Reprocessing Process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tadahiro Washiya; Atsuhiro Shibata; Toshiaki Kikuchi

2006-07-01

Crystallization is one of the remarkable technologies for future fuel reprocessing process that has safety and economical advantages. Japan Atomic Energy Agency (JAEA) (former Japan Nuclear Cycle Development Institute), Mitsubishi Material Corporation and Saitama University have been developing the crystallization process. In previous study, we carried out experimental studies with uranium, MOX and spent fuel conditions, and flowsheet analysis was considered. In association with these studies, an innovative continuous crystallizer and its system was developed to ensure high process performance. From the design study, an annular type continuous crystallizer was selected as the most promising design, and performance was confirmedmore » by small-scale test and engineering scale demonstration at uranium crystallization conditions. In this paper, the design study and the demonstration test results are described. (authors)« less

Non-invasive continuous imaging of drug release from soy-based skin equivalent using wide-field interferometry

NASA Astrophysics Data System (ADS)

Gabai, Haniel; Baranes-Zeevi, Maya; Zilberman, Meital; Shaked, Natan T.

2013-04-01

We propose an off-axis interferometric imaging system as a simple and unique modality for continuous, non-contact and non-invasive wide-field imaging and characterization of drug release from its polymeric device used in biomedicine. In contrast to the current gold-standard methods in this field, usually based on chromatographic and spectroscopic techniques, our method requires no user intervention during the experiment, and only one test-tube is prepared. We experimentally demonstrate imaging and characterization of drug release from soy-based protein matrix, used as skin equivalent for wound dressing with controlled anesthetic, Bupivacaine drug release. Our preliminary results demonstrate the high potential of our method as a simple and low-cost modality for wide-field imaging and characterization of drug release from drug delivery devices.

High-speed autofocusing of a cell using diffraction pattern

NASA Astrophysics Data System (ADS)

Oku, Hiromasa; Ishikawa, Masatoshi; Theodorus; Hashimoto, Koichi

2006-05-01

This paper proposes a new autofocusing method for observing cells under a transmission illumination. The focusing method uses a quick and simple focus estimation technique termed “depth from diffraction,” which is based on a diffraction pattern in a defocused image of a biological specimen. Since this method can estimate the focal position of the specimen from only a single defocused image, it can easily realize high-speed autofocusing. To demonstrate the method, it was applied to continuous focus tracking of a swimming paramecium, in combination with two-dimensional position tracking. Three-dimensional tracking of the paramecium for 70 s was successfully demonstrated.

Substrats poreux biodegradables prepares a partir de phases co-continues dans les melanges de polymeres immiscibles

NASA Astrophysics Data System (ADS)

Sarazin, Pierre

2003-06-01

In this thesis a novel approach to preparing biodegradable materials with highly structured and interconnected porosity is proposed. The method involves the controlled preparation of immiscible co-continuous polymer blends using melt-processing technology followed by a bulk solvent extraction step of one of the phases (the porogen phase). A co-continuous structure is defined as the state when each phase of the blend is fully interconnected through a continuous pathway. This method allows for the preparation of porous materials with highly controlled pore size, pore volume and pore shape which can then be transformed and shaped in various forms useful for biomedical applications. Various properties of the skin of the polymeric articles (closed-cell, open-cell, modification of the pore size) can be controlled. Initially, the study on the immiscible binary and compatibilized poly(L-lactide)/polystyrene blends (PLLA/PS) after extraction of the PS phase demonstrated that highly percolated blends exist from 40--75%PS and 40--60%PS for the binary and compatibilized blends, respectively. It is demonstrated that both the pore size and extent of co-continuity can be controlled through composition and interfacial modification. The subsequent part of our work treats of the preparation of porous PLLA from a blend of two biodegradable polymers and the performance of such porous materials. This portion of the work uses only polymer materials which have been medically approved for internal use. In this case, small amounts of the porogen phase can be tolerated in the final porous substrate. Co-continuous blends comprised of poly(L-lactide)/Poly(epsilon-caprolactone) PLLA/PCL, were prepared via melt processing. A wide range of phase sizes for the co-continuous blend is generated through a combination of concentration control and quiescent annealing. As the PLLA phase can not be dissolved selectively in PLLA/PS blends, the co-continuity range was evaluated indirectly. To precisely assess the formation of the co-continuous morphology, the polylactide was replaced by a poly(epsilon-caprolactone) (PCL) in the following work. PCL possesses a similar biocompatibility, although it exhibits a much slower degradation rate. These results practically allow for a separation of the effects of deformation/disintegration processes and coalescence on continuous and co-continuous morphology development. Coalescence phenomena for systems such as the PS in PCL case is clearly the dominant parameter controlling phase size at higher compositions. These results underline the requirement of co-continuity models to include parameters related to coalescence effects. The data indicate the significant potential of mixing temperature as a tool for the morphology control of co-continuous polymer blends. (Abstract shortened by UMI.)

Proceedings of the First International Summit on Intestinal Anastomotic Leak, Chicago, Illinois, October 4–5, 2012

PubMed Central

Shogan, Benjamin D.; An, Gary C.; Schardey, Hans M.; Matthews, Jeffrey B.; Umanskiy, Konstantin; Fleshman, James W.; Hoeppner, Jens; Fry, Donald E.; Garcia-Granereo, Eduardo; Jeekel, Hans; van Goor, Harry; Dellinger, E. Patchen; Konda, Vani; Gilbert, Jack A.; Auner, Gregory W.

2014-01-01

Abstract Objective: The first international summit on anastomotic leak was held in Chicago in October, 2012 to assess current knowledge in the field and develop novel lines of inquiry. The following report is a summary of the proceedings with commentaries and future prospects for clinical trials and laboratory investigations. Background: Anastomotic leakage remains a devastating problem for the patient, and a continuing challenge to the surgeon operating on high-risk areas of the gastrointestinal tract such as the esophagus and rectum. Despite the traditional wisdom that anastomotic leak is because of technique, evidence to support this is weak-to-non-existent. Outcome data continue to demonstrate that expert high-volume surgeons working in high-volume centers continue to experience anastomotic leaks and that surgeons cannot predict reliably which patients will leak. Methods: A one and one-half day summit was held and a small working group assembled to review current practices, opinions, scientific evidence, and potential paths forward to understand and decrease the incidence of anastomotic leak. Results: Results of a survey of the opinions of the group demonstrated that the majority of participants believe that anastomotic leak is a complicated biologic problem whose pathogenesis remains ill-defined. The group opined that anastomotic leak is underreported clinically, it is not because of technique except when there is gross inattention to it, and that results from animal models are mostly irrelevant to the human condition. Conclusions: A fresh and unbiased examination of the causes and strategies for prevention of anastomotic leak needs to be addressed by a continuous working group of surgeons, basic scientists, and clinical trialists to realize a real and significant reduction in its incidence and morbidity. Such a path forward is discussed. PMID:25215465

High-performance continuous-wave room temperature 4.0-μm quantum cascade lasers with single-facet optical emission exceeding 2 W

PubMed Central

Lyakh, A.; Maulini, R.; Tsekoun, A.; Go, R.; Von der Porten, S.; Pflügl, C.; Diehl, L.; Capasso, Federico; Patel, C. Kumar N.

2010-01-01

A strain-balanced, AlInAs/InGaAs/InP quantum cascade laser structure, designed for light emission at 4.0 μm using nonresonant extraction design approach, was grown by molecular beam epitaxy. Laser devices were processed in buried heterostructure geometry. An air-cooled laser system incorporating a 10-mm × 11.5-μm laser with antireflection-coated front facet and high-reflection-coated back facet delivered over 2 W of single-ended optical power in a collimated beam. Maximum continuous-wave room temperature wall plug efficiency of 5.0% was demonstrated for a high-reflection-coated 3.65-mm × 8.7-μm laser mounted on an aluminum nitride submount.

Beyond the Coral Triangle: high genetic diversity and near panmixia in Singapore's populations of the broadcast spawning sea star Protoreaster nodosus.

PubMed

Tay, Y C; Chng, M W P; Sew, W W G; Rheindt, F E; Tun, K P P; Meier, R

2016-08-01

The Coral Triangle is widely considered the most important centre of marine biodiversity in Asia while areas on its periphery such as the South China Sea, have received much less interest. Here, we demonstrate that a small population of the knobbly sea star Protoreaster nodosus in Singapore has similarly high levels of genetic diversity as comparable Indonesian populations from the Coral Triangle. The high genetic diversity of this population is remarkable because it is maintained despite decades of continued anthropogenic disturbance. We postulate that it is probably due to broadcast spawning which is likely to maintain high levels of population connectivity. To test this, we analysed 6140 genome-wide single nucleotide polymorphism (SNP) loci for Singapore's populations and demonstrate a pattern of near panmixia. We here document a second case of high genetic diversity and low genetic structure for a broadcast spawner in Singapore, which suggests that such species have high resilience against anthropogenic disturbances. The study demonstrates the feasibility and power of using genome-wide SNPs for connectivity studies of marine invertebrates without a sequenced genome.

Transfer-free, lithography-free, and micrometer-precision patterning of CVD graphene on SiO2 toward all-carbon electronics

NASA Astrophysics Data System (ADS)

Dong, Yibo; Xie, Yiyang; Xu, Chen; Li, Xuejian; Deng, Jun; Fan, Xing; Pan, Guanzhong; Wang, Qiuhua; Xiong, Fangzhu; Fu, Yafei; Sun, Jie

2018-02-01

A method of producing large area continuous graphene directly on SiO2 by chemical vapor deposition is systematically developed. Cu thin film catalysts are sputtered onto the SiO2 and pre-patterned. During graphene deposition, high temperature induces evaporation and balling of the Cu, and the graphene "lands onto" SiO2. Due to the high heating and growth rate, continuous graphene is largely completed before the Cu evaporation and balling. 60 nm is identified as the optimal thickness of the Cu for a successful graphene growth and μm-large feature size in the graphene. An all-carbon device is demonstrated based on this technique.

Post-event reviews: Using a quantitative approach for analysing incident response to demonstrate the value of business continuity programmes and increase planning efficiency.

PubMed

Vaidyanathan, Karthik

2017-01-01

Business continuity management is often thought of as a proactive planning process for minimising impact from large-scale incidents and disasters. While this is true, and it is critical to plan for the worst, consistently validating plan effectiveness against smaller disruptions can enable an organisation to gain key insights about its business continuity readiness, drive programme improvements, reduce costs and provide an opportunity to quantitatively demonstrate the value of the programme to management. This paper describes a post mortem framework which is used as a continuous improvement mechanism for tracking, reviewing and learning from real-world events at Microsoft Customer Service & Support. This approach was developed and adopted because conducting regular business continuity exercises proved difficult and expensive in a complex and distributed operations environment with high availability requirements. Using a quantitative approach to measure response to incidents, and categorising outcomes based on such responses, enables business continuity teams to provide data-driven insights to leadership, change perceptions of incident root cause, and instil a higher level of confidence towards disaster response readiness and incident management. The scope of the framework discussed here is specific to reviewing and driving improvements from operational incidents. However, the concept can be extended to learning and evolving readiness plans for other types of incidents.

On the Treatment of Field Quantities and Elemental Continuity in FEM Solutions.

PubMed

Jallepalli, Ashok; Docampo-Sanchez, Julia; Ryan, Jennifer K; Haimes, Robert; Kirby, Robert M

2018-01-01

As the finite element method (FEM) and the finite volume method (FVM), both traditional and high-order variants, continue their proliferation into various applied engineering disciplines, it is important that the visualization techniques and corresponding data analysis tools that act on the results produced by these methods faithfully represent the underlying data. To state this in another way: the interpretation of data generated by simulation needs to be consistent with the numerical schemes that underpin the specific solver technology. As the verifiable visualization literature has demonstrated: visual artifacts produced by the introduction of either explicit or implicit data transformations, such as data resampling, can sometimes distort or even obfuscate key scientific features in the data. In this paper, we focus on the handling of elemental continuity, which is often only continuous or piecewise discontinuous, when visualizing primary or derived fields from FEM or FVM simulations. We demonstrate that traditional data handling and visualization of these fields introduce visual errors. In addition, we show how the use of the recently proposed line-SIAC filter provides a way of handling elemental continuity issues in an accuracy-conserving manner with the added benefit of casting the data in a smooth context even if the representation is element discontinuous.

40 CFR 63.9636 - How do I demonstrate continuous compliance with the operation and maintenance requirements that...

Code of Federal Regulations, 2010 CFR

2010-07-01

... compliance with the operation and maintenance requirements that apply to me? 63.9636 Section 63.9636....9636 How do I demonstrate continuous compliance with the operation and maintenance requirements that... demonstrate continuous compliance with the operation and maintenance requirements in § 63.9600(b) by...

40 CFR 63.6005 - How do I monitor and collect data to demonstrate continuous compliance with the emission limits...

Code of Federal Regulations, 2010 CFR

2010-07-01

... demonstrate continuous compliance with the emission limits for tire cord production affected sources? 63.6005... Standards for Hazardous Air Pollutants: Rubber Tire Manufacturing Continuous Compliance Requirements for Tire Cord Production Affected Sources § 63.6005 How do I monitor and collect data to demonstrate...

40 CFR 63.5900 - How do I demonstrate continuous compliance with the standards?

Code of Federal Regulations, 2010 CFR

2010-07-01

... SOURCE CATEGORIES National Emissions Standards for Hazardous Air Pollutants: Reinforced Plastic Composites Production Continuous Compliance Requirements § 63.5900 How do I demonstrate continuous compliance...

Measuring edge-of-field water quality: Where we have been and the path forward

USDA-ARS?s Scientific Manuscript database

Heightened pressure to demonstrate the resource benefits of conservation practices and continued high-profile water quality impairments and concerns are increasing the need to quantify edge-of-field water quality. With this in mind, this manuscript summarizes previous developments in edge-of-field ...

Optimizing Web-Based Instruction: A Case Study Using Poultry Processing Unit Operations

ERIC Educational Resources Information Center

O' Bryan, Corliss A.; Crandall, Philip G.; Shores-Ellis, Katrina; Johnson, Donald M.; Ricke, Steven C.; Marcy, John

2009-01-01

Food companies and supporting industries need inexpensive, revisable training methods for large numbers of hourly employees due to continuing improvements in Hazard Analysis Critical Control Point (HACCP) programs, new processing equipment, and high employee turnover. HACCP-based food safety programs have demonstrated their value by reducing the…

10 CFR 63.203 - Implementation of Subpart K.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Implementation of Subpart K. 63.203 Section 63.203 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC... Implementation of Subpart K. DOE must demonstrate that normal operations at the Yucca Mountain site will and do...

10 CFR 63.203 - Implementation of Subpart K.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Implementation of Subpart K. 63.203 Section 63.203 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC... Implementation of Subpart K. DOE must demonstrate that normal operations at the Yucca Mountain site will and do...

10 CFR 63.203 - Implementation of Subpart K.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Implementation of Subpart K. 63.203 Section 63.203 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC... Implementation of Subpart K. DOE must demonstrate that normal operations at the Yucca Mountain site will and do...

10 CFR 63.203 - Implementation of Subpart K.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Implementation of Subpart K. 63.203 Section 63.203 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC... Implementation of Subpart K. DOE must demonstrate that normal operations at the Yucca Mountain site will and do...

10 CFR 63.203 - Implementation of Subpart K.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Implementation of Subpart K. 63.203 Section 63.203 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC... Implementation of Subpart K. DOE must demonstrate that normal operations at the Yucca Mountain site will and do...

Contextual Learning and Tech Prep Curriculum Integration.

ERIC Educational Resources Information Center

Edling, Walter

Because tech prep has the twin goals of preparing students for entry into postsecondary/continuing education or the work force after high school, tech prep programs require significant modification of conventional curricula and teaching methodologies. Both research and experience have demonstrated that the ability to transfer learning from one…

78 FR 40199 - Draft Spent Fuel Storage and Transportation Interim Staff Guidance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... NUCLEAR REGULATORY COMMISSION [NRC-2013-0140] Draft Spent Fuel Storage and Transportation Interim... Spent Fuel Storage and Transportation Interim Staff Guidance No. 24 (SFST-ISG-24), Revision 0, ``The Use of a Demonstration Program as Confirmation of Integrity for Continued Storage of High Burnup Fuel...

DEMONSTRATION OF THE AQUABLOK® SEDIMENT CAPPING TECHNOLOGY - INNOVATIVE TECHNOLOGY EVALUATION REPORT

EPA Science Inventory

AquaBlok^® is an innovative, proprietary clay polymer composite developed by AquaBlok, Ltd. of Toledo, OH, and represents an alternative to traditional sediment capping materials such as sand. It is designed to swell and form a continuous and highly impermeable isolatio...

Continuous Glucose Monitoring: Impact on Hypoglycemia.

PubMed

van Beers, Cornelis A J; DeVries, J Hans

2016-11-01

The necessity of strict glycemic control is unquestionable. However, hypoglycemia remains a major limiting factor in achieving satisfactory glucose control, and evidence is mounting to show that hypoglycemia is not benign. Over the past decade, evidence has consistently shown that real-time continuous glucose monitoring improves glycemic control in terms of lowering glycated hemoglobin levels. However, real-time continuous glucose monitoring has not met the expectations of the diabetes community with regard to hypoglycemia prevention. The earlier trials did not demonstrate any effect on either mild or severe hypoglycemia and the effect of real-time continuous glucose monitoring on nocturnal hypoglycemia was often not reported. However, trials specifically designed to reduce hypoglycemia in patients with a high hypoglycemia risk have demonstrated a reduction in hypoglycemia, suggesting that real-time continuous glucose monitoring can prevent hypoglycemia when it is specifically used for that purpose. Moreover, the newest generation of diabetes technology currently available commercially, namely sensor-augmented pump therapy with a (predictive) low glucose suspend feature, has provided more convincing evidence for hypoglycemia prevention. This article provides an overview of the hypoglycemia outcomes of randomized controlled trials that investigate the effect of real-time continuous glucose monitoring alone or sensor-augmented pump therapy with a (predictive) low glucose suspend feature. Furthermore, several possible explanations are provided why trials have not shown a reduction in severe hypoglycemia. In addition, existing evidence is presented of real-time continuous glucose monitoring in patients with impaired awareness of hypoglycemia who have the highest risk of severe hypoglycemia. © 2016 Diabetes Technology Society.

Continuous Glucose Monitoring

PubMed Central

van Beers, Cornelis A. J.; DeVries, J. Hans

2016-01-01

The necessity of strict glycemic control is unquestionable. However, hypoglycemia remains a major limiting factor in achieving satisfactory glucose control, and evidence is mounting to show that hypoglycemia is not benign. Over the past decade, evidence has consistently shown that real-time continuous glucose monitoring improves glycemic control in terms of lowering glycated hemoglobin levels. However, real-time continuous glucose monitoring has not met the expectations of the diabetes community with regard to hypoglycemia prevention. The earlier trials did not demonstrate any effect on either mild or severe hypoglycemia and the effect of real-time continuous glucose monitoring on nocturnal hypoglycemia was often not reported. However, trials specifically designed to reduce hypoglycemia in patients with a high hypoglycemia risk have demonstrated a reduction in hypoglycemia, suggesting that real-time continuous glucose monitoring can prevent hypoglycemia when it is specifically used for that purpose. Moreover, the newest generation of diabetes technology currently available commercially, namely sensor-augmented pump therapy with a (predictive) low glucose suspend feature, has provided more convincing evidence for hypoglycemia prevention. This article provides an overview of the hypoglycemia outcomes of randomized controlled trials that investigate the effect of real-time continuous glucose monitoring alone or sensor-augmented pump therapy with a (predictive) low glucose suspend feature. Furthermore, several possible explanations are provided why trials have not shown a reduction in severe hypoglycemia. In addition, existing evidence is presented of real-time continuous glucose monitoring in patients with impaired awareness of hypoglycemia who have the highest risk of severe hypoglycemia. PMID:27257169

Heated, humidified high-flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure?

PubMed

Kubicka, Zuzanna J; Limauro, Joseph; Darnall, Robert A

2008-01-01

The goal was to estimate the level of delivered continuous positive airway pressure by measuring oral cavity pressure with the mouth closed in infants of various weights and ages treated with heated, humidified high-flow nasal cannula at flow rates of 1-5 L/minute. We hypothesized that clinically relevant levels of continuous positive airway pressure would not be achieved if a nasal leak is maintained. After performing bench measurements and demonstrating that oral cavity pressure closely approximated levels of traditionally applied nasal continuous positive airway pressure, we successfully measured oral cavity pressure during heated, humidified, high-flow nasal cannula treatment in 27 infants. Small (outer diameter: 0.2 cm) cannulae were used for all infants, and flow rates were left as ordered by providers. Bench measurements showed that, for any given leak size, there was a nearly linear relationship between flow rate and pressure. The highest pressure achieved was 4.5 cmH2O (flow rate: 8 L/minute; leak: 3 mm). In our study infants (postmenstrual age: 29.1-44.7 weeks; weight: 835-3735 g; flow rate: 1-5 L/minute), no pressure was generated with the mouth open at any flow rate. With the mouth closed, the oral cavity pressure was related to both flow rate and weight. For infants of < or = 1500 g, there was a linear relationship between flow rate and oral cavity pressure. Oral cavity pressure can estimate the level of continuous positive airway pressure. Continuous positive airway pressure generated with heated, humidified, high-flow nasal cannula treatment depends on the flow rate and weight. Only in the smallest infants with the highest flow rates, with the mouth fully closed, can clinically significant but unpredictable levels of continuous positive airway pressure be achieved. We conclude that heated, humidified high-flow nasal cannula should not be used as a replacement for delivering continuous positive airway pressure.

40 CFR 63.9035 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 14 2010-07-01 2010-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.9035 Section 63.9035 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED)...

40 CFR 63.9035 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 14 2011-07-01 2011-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.9035 Section 63.9035 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED)...

40 CFR 63.7535 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 13 2010-07-01 2010-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.7535 Section 63.7535 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED)...

40 CFR 63.7332 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 13 2010-07-01 2010-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.7332 Section 63.7332 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED)...

40 CFR 63.6635 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 13 2010-07-01 2010-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.6635 Section 63.6635 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED)...

40 CFR 63.7120 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 13 2010-07-01 2010-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.7120 Section 63.7120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED)...

40 CFR 63.7946 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 13 2010-07-01 2010-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.7946 Section 63.7946 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED)...

40 CFR 63.9922 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 14 2011-07-01 2011-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.9922 Section 63.9922 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED)...

40 CFR 63.9633 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 14 2011-07-01 2011-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.9633 Section 63.9633 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED)...

Young People with High-Functioning Autism and Asperger's Syndrome Planning for and Anticipating the Move to College: What Supports a Positive Transition?

ERIC Educational Resources Information Center

Mitchell, Wendy; Beresford, Bryony

2014-01-01

For many young people in England, the move into continuing education involves a transfer from the school where they were educated to a further education college. For those with high-functioning autism or Asperger's syndrome, this can be a challenging process. Past research has demonstrated some of the problems that these young people can…

High-throughput continuous flow synthesis of nickel nanoparticles for the catalytic hydrodeoxygenation of guaiacol

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, Emily J.; Habas, Susan E.; Wang, Lu

2016-11-07

The translation of batch chemistries to high-throughput continuous flow methods dresses scaling, automation, and reproducibility concerns associated with the implementation of colloidally prepared nanoparticle (NP) catalysts for industrial catalytic processes. Nickel NPs were synthesized by the high-temperature amine reduction of a Ni2+ precursor using a continuous millifluidic (mF) flow method, achieving yields greater than 60%. The resulting Ni NP catalysts were compared against catalysts prepared in a batch reaction under conditions analogous to the continuous flow conditions with respect to total reaction volume, time, and temperature and by traditional incipient wetness (IW) impregnation for the hydrodeoxygenation (HDO) of guaiacol undermore » ex situ catalytic fast pyrolysis conditions. Compared to the IW method, the colloidally prepared NPs displayed increased morphological control and narrowed size distributions, and the NPs prepared by both methods showed similar size, shape, and crystallinity. The Ni NP catalyst synthesized by the continuous flow method exhibited similar H-adsorption site densities, site-time yields, and selectivities towards deoxygenated products as compared to the analogous batch reaction, and outperformed the IW catalyst with respect to higher selectivity to lower oxygen content products and a 6.9-fold slower deactivation rate. These results demonstrate the utility of synthesizing colloidal Ni NP catalysts using continuous flow methods while maintaining the catalytic properties displayed by the batch equivalent. Finally, this methodology can be extended to other catalytically relevant base metals for the high-throughput synthesis of metal NPs for the catalytic production of biofuels.« less

Ultra-high Q terahertz whispering-gallery modes in a silicon resonator

NASA Astrophysics Data System (ADS)

Vogt, Dominik Walter; Leonhardt, Rainer

2018-05-01

We report on the first experimental demonstration of terahertz (THz) whispering-gallery modes (WGMs) with an ultra-high quality factor of 1.5 × 104 at 0.62 THz. The WGMs are observed in a high resistivity float zone silicon spherical resonator coupled to a sub-wavelength silica waveguide. A detailed analysis of the coherent continuous wave THz spectroscopy measurements combined with a numerical model based on Mie-Debye-Aden-Kerker theory allows us to unambiguously identify the observed higher order radial THz WGMs.

Progress in high-power continuous-wave quantum cascade lasers [Invited].

PubMed

Figueiredo, Pedro; Suttinger, Matthew; Go, Rowel; Tsvid, Eugene; Patel, C Kumar N; Lyakh, Arkadiy

2017-11-01

Multi-watt continuous-wave room temperature operation with efficiency exceeding 10% has been demonstrated for quantum cascade lasers essentially in the entire mid-wave and long-wave infrared spectral regions. Along with interband cascade lasers, these devices are the only room-temperature lasers that directly convert electrical power into mid- and long-infrared optical power. In this paper, we review the progress in high-power quantum cascade lasers made over the last 10 years. Specifically, an overview of the most important active region, waveguide, and thermal design techniques is presented, and various aspects of die packaging for high-power applications are discussed. Prospects of power scaling with lateral device dimensions for reaching optical power level in the range from 10 W to 20 W are also analyzed. Finally, coherent and spectral beam-combining techniques for very high-power infrared platforms are discussed.

Dual Superlyophobic Copper Foam with Good Durability and Recyclability for High Flux, High Efficiency, and Continuous Oil-Water Separation.

PubMed

Zhou, Wenting; Li, Song; Liu, Yan; Xu, Zhengzheng; Wei, Sufeng; Wang, Guoyong; Lian, Jianshe; Jiang, Qing

2018-03-21

Traditional oil-water separation materials have to own ultrahigh or ultralow surface energy. Thus, they can only be wetted by one of the two, oil or water. Our experiment here demonstrates that the wettability in oil-water mixtures can be tuned by oil and water initially. Hierarchical voids are built on commercial copper foams with the help of hydrothermally synthesized titanium dioxide nanorods. The foams can be easily wetted by both oil and water. The water prewetted foams are superhydrophilic and superoleophobic under oil-water mixtures, meanwhile the oil prewetted foams are superoleophilic and superhydrophobic. In this paper, many kinds of water-oil mixtures were separated by two foams, prewetted by corresponding oil or water, respectively, combining a straight tee in a high flux, high efficiency, and continuous mode. This research indicates that oil-water mixtures can be separated more eco-friendly and at lower cost.

SiC Field Effect Transistor Technology Demonstrating Prolonged Stable Operation at 500 C

NASA Technical Reports Server (NTRS)

Neudeck, Philip G.; Spry, David J.; Chen, Liang-Yu; Okojie, Robert S.; Beheim, Glenn M.; Meredith, Roger; Ferrier, Terry

2006-01-01

While there have been numerous reports of short-term transistor operation at 500 degree C or above, these devices have previously not demonstrated sufficient long-term operational durability at 500 degree C to be considered viable for most envisioned applications. This paper reports the development of Silicone Carbi field effect transistors capable of long-term electrical operation at 500 degree C. A 6H-SiC MESFET was packaged and subjected to continuous electrical operation while residing in a 500 degree C oven in oxidizing air atmosphere for over 2400 hours. The transistor gain, saturation current (IDSS), and on-resistance (RDS) changed by less than 20% from initial values throughout the duration of the biased 500 degree C test. Another high-temperature packaged 6H-SiC MESFET was employed to form a simple one-stage high-temperature low-frequency voltage amplifier. This single-stage common-source amplifier demonstrated stable continuous electrical operation (negligible changes to gain and operating biases) for over 600 hours while residing in a 500 degree C air ambient oven. In both cases, increased leakage from annealing of the Schottky gate-to-channel diode was the dominant transistor degradation mechanism that limited the duration of 500 degree C electrical operation.

40 CFR 63.7913 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7913 How do I demonstrate...

40 CFR 63.7913 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7913 How do I demonstrate...

40 CFR 63.7913 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7913 How do I demonstrate...

40 CFR 63.7913 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7913 How do I demonstrate...

40 CFR 63.7913 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7913 How do I demonstrate...

Smart-actuated continuous moldline technology (CMT) mini wind tunnel test

NASA Astrophysics Data System (ADS)

Pitt, Dale M.; Dunne, James P.; Kilian, Kevin J.

1999-07-01

The Smart Aircraft and Marine Propulsion System Demonstration (SAMPSON) Program will culminate in two separate demonstrations of the application of Smart Materials and Structures technology. One demonstration will be for an aircraft application and the other for marine vehicles. The aircraft portion of the program will examine the application of smart materials to aircraft engine inlets which will deform the inlet in-flight in order to regulate the airflow rate into the engine. Continuous Moldline Technology (CMT), a load-bearing reinforced elastomer, will enable the use of smart materials in this application. The capabilities of CMT to withstand high-pressure subsonic and supersonic flows were tested in a sub-scale mini wind- tunnel. The fixture, used as the wind-tunnel test section, was designed to withstand pressure up to 100 psi. The top and bottom walls were 1-inch thick aluminum and the side walls were 1-inch thick LEXAN. High-pressure flow was introduced from the Boeing St. Louis poly-sonic wind tunnel supply line. CMT walls, mounted conformal to the upper and lower surfaces, were deflected inward to obtain a converging-diverging nozzle. The CMT walls were instrumented for vibration and deflection response. Schlieren photography was used to establish shock wave motion. Static pressure taps, embedded within one of the LEXAN walls, monitored pressure variation in the mini-wind tunnel. High mass flow in the exit region. This test documented the response of CMT technology in the presence of high subsonic flow and provided data to be used in the design of the SAMPSON Smart Inlet.

Continuous centrifuge decelerator for polar molecules.

PubMed

Chervenkov, S; Wu, X; Bayerl, J; Rohlfes, A; Gantner, T; Zeppenfeld, M; Rempe, G

2014-01-10

Producing large samples of slow molecules from thermal-velocity ensembles is a formidable challenge. Here we employ a centrifugal force to produce a continuous molecular beam with a high flux at near-zero velocities. We demonstrate deceleration of three electrically guided molecular species, CH3F, CF3H, and CF3CCH, with input velocities of up to 200  m s(-1) to obtain beams with velocities below 15  m s(-1) and intensities of several 10(9)  mm(-2) s(-1). The centrifuge decelerator is easy to operate and can, in principle, slow down any guidable particle. It has the potential to become a standard technique for continuous deceleration of molecules.

Reconstruction-free sensitive wavefront sensor based on continuous position sensitive detectors.

PubMed

Godin, Thomas; Fromager, Michael; Cagniot, Emmanuel; Brunel, Marc; Aït-Ameur, Kamel

2013-12-01

We propose a new device that is able to perform highly sensitive wavefront measurements based on the use of continuous position sensitive detectors and without resorting to any reconstruction process. We demonstrate experimentally its ability to measure small wavefront distortions through the characterization of pump-induced refractive index changes in laser material. In addition, it is shown using computer-generated holograms that this device can detect phase discontinuities as well as improve the quality of sharp phase variations measurements. Results are compared to reference Shack-Hartmann measurements, and dramatic enhancements are obtained.

Construction and commissioning of the compact energy-recovery linac at KEK

NASA Astrophysics Data System (ADS)

Akemoto, Mitsuo; Arakawa, Dai; Asaoka, Seiji; Cenni, Enrico; Egi, Masato; Enami, Kazuhiro; Endo, Kuninori; Fukuda, Shigeki; Furuya, Takaaki; Haga, Kaiichi; Hajima, Ryoichi; Hara, Kazufumi; Harada, Kentaro; Honda, Tohru; Honda, Yosuke; Honma, Teruya; Hosoyama, Kenji; Kako, Eiji; Katagiri, Hiroaki; Kawata, Hiroshi; Kobayashi, Yukinori; Kojima, Yuuji; Kondou, Yoshinari; Tanaka, Olga; Kume, Tatsuya; Kuriki, Masao; Matsumura, Hiroshi; Matsushita, Hideki; Michizono, Shinichiro; Miura, Takako; Miyajima, Tsukasa; Nagahashi, Shinya; Nagai, Ryoji; Nakai, Hirotaka; Nakajima, Hiromitsu; Nakamura, Norio; Nakanishi, Kota; Nigorikawa, Kazuyuki; Nishimori, Nobuyuki; Nogami, Takashi; Noguchi, Shuichi; Obina, Takashi; Qiu, Feng; Sagehashi, Hidenori; Sakai, Hiroshi; Sakanaka, Shogo; Sasaki, Shinichi; Satoh, Kotaro; Sawamura, Masaru; Shimada, Miho; Shinoe, Kenji; Shishido, Toshio; Tadano, Mikito; Takahashi, Takeshi; Takai, Ryota; Takenaka, Tateru; Tanimoto, Yasunori; Uchiyama, Takashi; Ueda, Akira; Umemori, Kensei; Watanabe, Ken; Yamamoto, Masahiro

2018-01-01

Energy-recovery linacs (ERLs) are promising for advanced synchrotron light sources, high-power free electron lasers (FELs), high-brightness gamma-ray sources, and electron-ion colliders. To demonstrate the critical technology of ERL-based light sources, we have designed and constructed a test accelerator, the compact ERL (cERL). Using advanced technology that includes a photocathode direct current (DC) electron gun and two types of 1.3-GHz-frequency superconducting cavities, the cERL was designed to be capable of recirculating low emittance (≤1 mm ṡ mrad) and high average-current (≥10 mA) electron beams while recovering the beam energy. During initial commissioning, the cERL demonstrated successful recirculation of high-quality beams with normalized transverse emittance of ∼0.14 mm ṡ mrad and momentum spread of ∼1.2 × 10-4 (rms) at a beam energy of 20 MeV and bunch charge below 100 fC. Energy recovery in the superconducting main linac was also demonstrated for high-average-current continuous-wave beams. These results constitute an important milestone toward realizing ERL-based light sources.

Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture.

PubMed

Lee, Kevin S; Boccazzi, Paolo; Sinskey, Anthony J; Ram, Rajeev J

2011-05-21

This work reports on an instrument capable of supporting automated microscale continuous culture experiments. The instrument consists of a plastic-PDMS device capable of continuous flow without volume drift or evaporation. We apply direct computer controlled machining and chemical bonding fabrication for production of fluidic devices with a 1 mL working volume, high oxygen transfer rate (k(L)a≈0.025 s(-1)), fast mixing (2 s), accurate flow control (±18 nL), and closed loop control over temperature, cell density, dissolved oxygen, and pH. Integrated peristaltic pumps and valves provide control over input concentrations and allow the system to perform different types of cell culture on a single device, such as batch, chemostat, and turbidostat continuous cultures. Continuous cultures are demonstrated without contamination for 3 weeks in a single device and both steady state and dynamically controlled conditions are possible. © The Royal Society of Chemistry 2011

Continuous background light significantly increases flashing-light enhancement of photosynthesis and growth of microalgae.

PubMed

Abu-Ghosh, Said; Fixler, Dror; Dubinsky, Zvy; Iluz, David

2015-01-01

Under specific conditions, flashing light enhances the photosynthesis rate in comparison to continuous illumination. Here we show that a combination of flashing light and continuous background light with the same integrated photon dose as continuous or flashing light alone can be used to significantly enhance photosynthesis and increase microalgae growth. To test this hypothesis, the green microalga Dunaliella salina was exposed to three different light regimes: continuous light, flashing light, and concomitant application of both. Algal growth was compared under three different integrated light quantities; low, intermediate, and moderately high. Under the combined light regime, there was a substantial increase in all algal growth parameters, with an enhanced photosynthesis rate, within 3days. Our strategy demonstrates a hitherto undescribed significant increase in photosynthesis and algal growth rates, which is beyond the increase by flashing light alone. Copyright © 2015 Elsevier Ltd. All rights reserved.

40 CFR 63.2171 - How do I demonstrate continuous compliance with the emission limitations?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Nutritional Yeast Continuous Compliance Requirements § 63.2171 How do I demonstrate continuous compliance with... each fermentation stage for which emission limits apply. To calculate the 12-month percentage, do not...

45 CFR 260.76 - What special rules apply to States that are continuing evaluations of their waiver demonstrations?

Code of Federal Regulations, 2013 CFR

2013-10-01

... demonstrations? If a State is continuing research that employs an experimental design in order to complete an impact evaluation of a waiver demonstration, the experimental and control groups may continue to be... 45 Public Welfare 2 2013-10-01 2012-10-01 true What special rules apply to States that are...

45 CFR 260.76 - What special rules apply to States that are continuing evaluations of their waiver demonstrations?

Code of Federal Regulations, 2014 CFR

2014-10-01

... demonstrations? If a State is continuing research that employs an experimental design in order to complete an impact evaluation of a waiver demonstration, the experimental and control groups may continue to be... 45 Public Welfare 2 2014-10-01 2012-10-01 true What special rules apply to States that are...

40 CFR 63.9635 - How do I demonstrate continuous compliance with the work practice standards that apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... compliance with the work practice standards that apply to me? 63.9635 Section 63.9635 Protection of... demonstrate continuous compliance with the work practice standards that apply to me? (a) You must demonstrate continuous compliance with the work practice standard requirements in § 63.9591 by operating in accordance...

Follow-up status of patients with angiographically normal coronary arteries and panic disorder

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beitman, B.D.; Kushner, M.G.; Basha, I.

1991-03-27

Cardiology patients with normal coronary angiography demonstrate continuing and substantial social, health, and work disability. The authors hypothesized that the diagnosis of panic disorder would mark those for whom continuing disability is most likely. They interviewed 72 such patients at the time of their normal angiogram, and then again an average of 38 months later. Those with panic disorder (n=36) demonstrated significantly more disability at follow-up than did the other study patients. They conclude that those patients with normal angiograms who have panic disorder are more disabled than those who do not have panic disorder. Panic disorder in psychiatric samplesmore » has been shown to be highly treatable. Therefore, early identification and treatment of panic disorder in this group is likely to minimize the suffering associated with this condition.« less

Engineering non-linear resonator mode interactions in circuit QED by continuous driving: Introduction

NASA Astrophysics Data System (ADS)

Pfaff, Wolfgang; Reagor, Matthew; Heeres, Reinier; Ofek, Nissim; Chou, Kevin; Blumoff, Jacob; Leghtas, Zaki; Touzard, Steven; Sliwa, Katrina; Holland, Eric; Krastanov, Stefan; Frunzio, Luigi; Devoret, Michel; Jiang, Liang; Schoelkopf, Robert

2015-03-01

High-Q microwave resonators show great promise for storing and manipulating quantum states in circuit QED. Using resonator modes as such a resource in quantum information processing applications requires the ability to manipulate the state of a resonator efficiently. Further, one must engineer appropriate coupling channels without spoiling the coherence properties of the resonator. We present an architecture that combines millisecond lifetimes for photonic quantum states stored in a linear resonator with fast measurement provided by a low-Q readout resonator. We demonstrate experimentally how a continuous drive on a transmon can be utilized to generate highly non-classical photonic states inside the high-Q resonator via effective nonlinear resonator mode interactions. Our approach opens new avenues for using modes of long-lived linear resonators in the circuit QED platform for quantum information processing tasks.

40 CFR 63.7898 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Tanks § 63.7898 How do I demonstrate continuous... maximum HAP vapor pressure determined according to the procedures in § 63.7944 for the remediation...

40 CFR 63.7898 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Tanks § 63.7898 How do I demonstrate continuous... maximum HAP vapor pressure determined according to the procedures in § 63.7944 for the remediation...

40 CFR 63.7898 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Tanks § 63.7898 How do I demonstrate continuous... maximum HAP vapor pressure determined according to the procedures in § 63.7944 for the remediation...

40 CFR 63.7898 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Tanks § 63.7898 How do I demonstrate continuous... maximum HAP vapor pressure determined according to the procedures in § 63.7944 for the remediation...

U.S. Army High Energy Laser (HEL) technology program

NASA Astrophysics Data System (ADS)

Lavan, Michael J.; Wachs, John J.

2011-11-01

The US Army is investing in Solid State Laser (SSL) technology to assess counter rocket, artillery, and mortar (C-RAM) and counter unmanned aerial vehicle (C-UAV) capabilities of solid state based HEL systems, as well as other potential applications for HELs of interest to the Army. The Army HEL program thrust areas are systematically moving the technology forward toward weaponization, including solid state laser technologies, advances in beam control technology, and conducting major demonstrations. The High Energy Laser Mobile Demonstrator (HELMD) will be a major step toward demonstrating HEL weapon capability to the soldier. The US Army will continue to pursue technologies that enable more compact systems compatible with, for example, a Stryker tactical vehicle as a crucial part of our strategy to provide a capability to the warfighter that can maneuver with the force.

21 CFR 700.14 - Use of vinyl chloride as an ingredient, including propellant of cosmetic aerosol products.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS GENERAL Requirements for Specific Cosmetic... inhaled at high concentrations. Studies also demonstrate carcinogenic effects in animals as a result of..., including liver cancer, in workers engaged in the polymerization of vinyl chloride. It is the view of the...

Extended plate and beam demonstration home

Treesearch

Patricia Gunderson; Vladimir Kochkin; Xiping Wang

2018-01-01

An extended plate and beam (EP&B) design was developed at Home Innovation Research Labs (Upper Marlboro, Maryland) in an effort to provide traditional light-frame wall construction details that are compatible with continuous insulating sheathing. This would encourage wide-spread adoption of high-R walls and promote greater energy efficiency in new houses. The...

High Density Lidar and Orthophotography in UXO Wide Area Assessment (Rev 1)

DTIC Science & Technology

2007-08-01

The demonstration provided important insights regarding the appropriate uses and confidence levels for both lidar and orthophoto technologies. At...Patterns ................................................................................ 3-34 3.7.18 Lidar and Orthophoto Positional Accuracy...02-D-2008 Page iii CONTENTS (Continued) APPENDICES A Lidar and Orthophoto Positional Accuracy Results B Combining Lidar Data from Multiple

Development of phytoplankton communities and common off-flavors in a biofloc technology system used to culture channel catfish Ictalurus punctatus

USDA-ARS?s Scientific Manuscript database

The use of biofloc technology production systems continues to increase in the aquaculture industry worldwide. Recent research demonstrated that outdoor biofloc systems can be used to produce high yields of channel catfish (Ictalurus punctatus). However, studies have not yet been performed to deter...

Confronting Task Difficulty in Ego Involvement: Change in Performance Goals

ERIC Educational Resources Information Center

Kumar, Shamala; Jagacinski, Carolyn M.

2011-01-01

Both Dweck (1986) and Nicholls (1984) proposed that when ego-involved individuals encounter difficulty, they would begin to doubt their level of ability, and as a consequence, their commitment to the goal of demonstrating high ability would decline. As difficulty continued, perceived ability would decline, and eventually the goal would be…

Examining Gender and the Academic Achievement of Students with Emotional Disturbance

ERIC Educational Resources Information Center

Rice, Elisabeth Hess; Yen, Cherng-Jyh

2010-01-01

Students with emotional disturbance (ED) have significant academic deficits (Trout, Nordness, Pierce, & Epstein, 2003; Lane, 2004). Even after identification and school intervention, students with ED continue to demonstrate limited academic achievement and high rates of drop out and school failure, with 80-90% scoring below grade level on tests of…

High-Rate Field Demonstration of Large-Alphabet Quantum Key Distribution

DTIC Science & Technology

2016-12-13

COW , 2015 This work Figure 4: Comparison of our P&M DO-QKD results to previously published QKD system records, chosen to represent either secure...record for continuous-variable QKD (33). BBM92: secure throughput record for two-dimensional entanglement-based QKD (34). COW : distance record for QKD (19). 15

High-Rate Field Demonstration of Large-Alphabet Quantum Key Distribution

DTIC Science & Technology

2016-10-12

BBM92, 2009 COW , 2015 This work FIG. 4. Comparison of our P&M DO-QKD results to previously published QKD system records, chosen to represent either...distance record for continuous-variable QKD [29]. BBM92: secure throughput record for two-dimensional entanglement-based QKD [30]. COW : distance record for

High-Rate Field Demonstration of Large-Alphabet Quantum Key Distribution

DTIC Science & Technology

2016-12-08

COW , 2015 This work Figure 4: Comparison of our P&M DO-QKD results to previously published QKD system records, chosen to represent either secure...record for continuous-variable QKD (33). BBM92: secure throughput record for two-dimensional entanglement-based QKD (34). COW : distance record for QKD (19). 15

Transient hypothyroidism after withdrawal of thyroxin therapy

PubMed Central

Distiller, L. A.; Joffe, B. I.

1975-01-01

Continued administration of large doses of thyroid may not produce hyperthyroidism in euthyroid individuals. Cessation of prolonged high-dosage thyroid replacement can cause transient clinical and biochemical hypothyroidism owing to pituitary suppression. A case is recorded in which both these phenomena are well demonstrated. This case highlights these basic endocrinological principles. PMID:1197170

High-yield, in vitro protein expression using a continuous-exchange, coupled transcription/ translation system.

PubMed

Martin, G A; Kawaguchi, R; Lam, Y; DeGiovanni, A; Fukushima, M; Mutter, W

2001-10-01

The Rapid Translation System (RTS 500) (Roche Molecular Biochemicals) is a high-yield protein expression system that utilizes an enhanced E. coli lysate for an in vitro transcription/translation reaction. In contrast to conventional transcription/translation, this system allows protein expression to continue for more than 24 h. We demonstrated the utility of the RTS 500 by expressing different soluble and active proteins that generally pose problems in cell-based expression systems. We first expressed GFP-lunasin, a fusion protein that, because of its toxicity, has been impossible to produce in whole cells. The second protein we expressed, human interleukin-2 (IL-2), is generally difficult to produce, either as the native molecule or as a GSTfusion protein, in a soluble form in bacteria. Finally, we demonstrated the capacity of the RTS 500 to co-express proteins, by the simultaneous production of GFP and CAT in a single reaction. This new technology appears to be particularly usefulfor the convenient production of preparative amounts (100-900 microg) of proteins that are toxic or insoluble in cell-based systems.

Continuous-time quantum Monte Carlo calculation of multiorbital vertex asymptotics

NASA Astrophysics Data System (ADS)

Kaufmann, Josef; Gunacker, Patrik; Held, Karsten

2017-07-01

We derive the equations for calculating the high-frequency asymptotics of the local two-particle vertex function for a multiorbital impurity model. These relate the asymptotics for a general local interaction to equal-time two-particle Green's functions, which we sample using continuous-time quantum Monte Carlo simulations with a worm algorithm. As specific examples we study the single-orbital Hubbard model and the three t2 g orbitals of SrVO3 within dynamical mean-field theory (DMFT). We demonstrate how the knowledge of the high-frequency asymptotics reduces the statistical uncertainties of the vertex and further eliminates finite-box-size effects. The proposed method benefits the calculation of nonlocal susceptibilities in DMFT and diagrammatic extensions of DMFT.

Scanning two-photon continuous flow lithography for synthesis of high-resolution 3D microparticles.

PubMed

Shaw, Lucas A; Chizari, Samira; Shusteff, Maxim; Naghsh-Nilchi, Hamed; Di Carlo, Dino; Hopkins, Jonathan B

2018-05-14

Demand continues to rise for custom-fabricated and engineered colloidal microparticles across a breadth of application areas. This paper demonstrates an improvement in the fabrication rate of high-resolution 3D colloidal particles by using two-photon scanning lithography within a microfluidic channel. To accomplish this, we present (1) an experimental setup that supports fast, 3D scanning by synchronizing a galvanometer, piezoelectric stage, and an acousto-optic switch, and (2) a new technique for modifying the laser's scan path to compensate for the relative motion of the rapidly-flowing photopolymer medium. The result is an instrument that allows for rapid conveyor-belt-like fabrication of colloidal objects with arbitrary 3D shapes and micron-resolution features.

Flexible Transparent Conductive Films with High Performance and Reliability Using Hybrid Structures of Continuous Metal Nanofiber Networks for Flexible Optoelectronics.

PubMed

Park, Juyoung; Hyun, Byung Gwan; An, Byeong Wan; Im, Hyeon-Gyun; Park, Young-Geun; Jang, Junho; Park, Jang-Ung; Bae, Byeong-Soo

2017-06-21

We report an Ag nanofiber-embedded glass-fabric reinforced hybrimer (AgNF-GFRHybrimer) composite film as a reliable and high-performance flexible transparent conducting film. The continuous AgNF network provides superior optoelectronic properties of the composite film by minimizing transmission loss and junction resistance. In addition, the excellent thermal/chemical stability and mechanical durability of the GFRHybrimer matrix provides enhanced mechanical durability and reliability of the final AgNF-GFRHybrimer composite film. To demonstrate the availability of our AgNF-GFRHybrimer composite as a transparent conducting film, we fabricated a flexible organic light-emitting diode (OLED) device on the AgNF-GFRHybrimer film; the OLED showed stable operation during a flexing.

Test and evaluation of the HIDEC engine uptrim algorithm. [Highly Integrated Digital Electronic Control for aircraft

NASA Technical Reports Server (NTRS)

Ray, R. J.; Myers, L. P.

1986-01-01

The highly integrated digital electronic control (HIDEC) program will demonstrate and evaluate the improvements in performance and mission effectiveness that result from integrated engine-airframe control systems. Performance improvements will result from an adaptive engine stall margin mode, a highly integrated mode that uses the airplane flight conditions and the resulting inlet distortion to continuously compute engine stall margin. When there is excessive stall margin, the engine is uptrimmed for more thrust by increasing engine pressure ratio (EPR). The EPR uptrim logic has been evaluated and implemente into computer simulations. Thrust improvements over 10 percent are predicted for subsonic flight conditions. The EPR uptrim was successfully demonstrated during engine ground tests. Test results verify model predictions at the conditions tested.

High throughput photo-oxidations in a packed bed reactor system.

PubMed

Kong, Caleb J; Fisher, Daniel; Desai, Bimbisar K; Yang, Yuan; Ahmad, Saeed; Belecki, Katherine; Gupton, B Frank

2017-12-01

The efficiency gains produced by continuous-flow systems in conducting photochemical transformations have been extensively demonstrated. Recently, these systems have been used in developing safe and efficient methods for photo-oxidations using singlet oxygen generated by photosensitizers. Much of the previous work has focused on the use of homogeneous photocatalysts. The development of a unique, packed-bed photoreactor system using immobilized rose bengal expands these capabilities as this robust photocatalyst allows access to and elaboration from these highly useful building blocks without the need for further purification. With this platform we were able to demonstrate a wide scope of singlet oxygen ene, [4+2] cycloadditions and heteroatom oxidations. Furthermore, we applied this method as a strategic element in the synthesis of the high-volume antimalarial artemisinin. Copyright © 2017. Published by Elsevier Ltd.

High-speed varifocal imaging with a tunable acoustic gradient index of refraction lens.

PubMed

Mermillod-Blondin, Alexandre; McLeod, Euan; Arnold, Craig B

2008-09-15

Fluidic lenses allow for varifocal optical elements, but current approaches are limited by the speed at which focal length can be changed. Here we demonstrate the use of a tunable acoustic gradient (TAG) index of refraction lens as a fast varifocal element. The optical power of the TAG lens varies continuously, allowing for rapid selection and modification of the effective focal length at time scales of 1 mus and shorter. The wavefront curvature applied to the incident light is experimentally quantified as a function of time, and single-frame imaging is demonstrated. Results indicate that the TAG lens can successfully be employed to perform high-rate imaging at multiple locations.

Development of AlN/Epoxy Composites with Enhanced Thermal Conductivity.

PubMed

Xu, Yonggang; Yang, Chi; Li, Jun; Mao, Xiaojian; Zhang, Hailong; Hu, Song; Wang, Shiwei

2017-12-18

AlN/epoxy composites with high thermal conductivity were successfully prepared by infiltrating epoxy into AlN porous ceramics which were fabricated by gelcasting of foaming method. The microstructure, mechanical, and thermal properties of the resulting composites were investigated. The compressive strengths of the AlN/epoxy composites were enhanced compared with the pure epoxy. The AlN/epoxy composites demonstrate much higher thermal conductivity, up to 19.0 W/(m·K), compared with those by the traditional particles filling method, because of continuous thermal channels formed by the walls and struts of AlN porous ceramics. This study demonstrates a potential route to manufacture epoxy-based composites with extremely high thermal conductivity.

Development of AlN/Epoxy Composites with Enhanced Thermal Conductivity

PubMed Central

Xu, Yonggang; Yang, Chi; Li, Jun; Zhang, Hailong; Hu, Song; Wang, Shiwei

2017-01-01

AlN/epoxy composites with high thermal conductivity were successfully prepared by infiltrating epoxy into AlN porous ceramics which were fabricated by gelcasting of foaming method. The microstructure, mechanical, and thermal properties of the resulting composites were investigated. The compressive strengths of the AlN/epoxy composites were enhanced compared with the pure epoxy. The AlN/epoxy composites demonstrate much higher thermal conductivity, up to 19.0 W/(m·K), compared with those by the traditional particles filling method, because of continuous thermal channels formed by the walls and struts of AlN porous ceramics. This study demonstrates a potential route to manufacture epoxy-based composites with extremely high thermal conductivity. PMID:29258277

Thallium as a tracer for preindustrial volcanic eruptions in an ice core record from Illimani, Bolivia.

PubMed

Kellerhals, Thomas; Tobler, Leonhard; Brütsch, Sabina; Sigl, Michael; Wacker, Lukas; Gäggeler, Heinz W; Schwikowski, Margit

2010-02-01

Trace element records from glacier and ice sheet archives provide insights into biogeochemical cycles, atmospheric circulation changes, and anthropogenic pollution history. We present the first continuous high-resolution thallium (Tl) record, derived from an accurately dated ice core from tropical South America, and discuss Tl as a tracer for volcanic eruptions. We identify four prominent Tl peaks and propose that they represent signals from the massive explosive eruptions of the "unknown 1258" A.D. volcano, of Kuwae ( approximately 1450 A.D.), Tambora (1815 A.D.), and Krakatoa (1883 A.D.). The highly resolved record was obtained with an improved setup for the continuous analysis of trace elements in ice with inductively coupled plasma sector field mass spectrometry (ICP-SFMS). The new setup allowed for a stronger initial acidification of the meltwater and shorter tubing length, thereby reducing the risk of memory effects and losses of analytes to the capillary walls. With a comparison of the continuous method to the established conventional decontamination and analysis procedure for discrete samples, we demonstrate the accuracy of the continuous method for Tl analyses.

ACR Appropriateness Criteria®  Resectable Rectal Cancer

PubMed Central

2012-01-01

The management of resectable rectal cancer continues to be guided by clinical trials and advances in technique. Although surgical advances including total mesorectal excision continue to decrease rates of local recurrence, the management of locally advanced disease (T3-T4 or N+) benefits from a multimodality approach including neoadjuvant concomitant chemotherapy and radiation. Circumferential resection margin, which can be determined preoperatively via MRI, is prognostic. Toxicity associated with radiation therapy is decreased by placing the patient in the prone position on a belly board, however for patients who cannot tolerate prone positioning, IMRT decreases the volume of normal tissue irradiated. The use of IMRT requires knowledge of the patterns of spreads and anatomy. Clinical trials demonstrate high variability in target delineation without specific guidance demonstrating the need for peer review and the use of a consensus atlas. Concomitant with radiation, fluorouracil based chemotherapy remains the standard, and although toxicity is decreased with continuous infusion fluorouracil, oral capecitabine is non-inferior to the continuous infusion regimen. Additional chemotherapeutic agents, including oxaliplatin, continue to be investigated, however currently should only be utilized on clinical trials as increased toxicity and no definitive benefit has been demonstrated in clinical trials. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every two years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. PMID:23006527

40 CFR 63.7940 - By what date must I conduct performance tests or other initial compliance demonstrations?

Code of Federal Regulations, 2010 CFR

2010-07-01

... compliance is not demonstrated using a performance test or design evaluation, you must demonstrate initial... performance tests or other initial compliance demonstrations? 63.7940 Section 63.7940 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS...

Applications of High-Q Microresonators in Cavity Optomechanics and Nonlinear Photonics

NASA Astrophysics Data System (ADS)

Jiang, Wei C.

Optical microresonators confining light to small volumes are indispensable for a great variety of studies and applications. This thesis is devoted to a study of cavity optomechanical and nonlinear optical phenomena in high-Q microresonators with different materials and structures. Based on that, it proposes and demonstrates several novel schemes and device platforms that exhibit great potential for various applications ranging from frequency metrology and quantum photonics, to information processing and sensing. The thesis starts with a demonstration of a high-frequency (above 1 GHz) regenerative optomechanical oscillator based on a 2-mum-radius high-Q silicon microdisk resonator in the silicon-on-insulator platform with an ultra-low threshold pump power at room temperature and atmosphere. It then continues to explore the cavity optomechanics in single-crystal lithium niobate. A compact lithium niobate microdisk optomechanical resonator with high optical and mechanical qualities, large optomechanical coupling, and high mechanical frequency is achieved, enabling the demonstration of regenerative oscillation in the ambience. Meanwhile, I propose and investigate a novel approach for single molecule detection that utilizes the optical spring effect in a high-Q coherent optomechanical oscillator to dramatically enhance the sensing resolution by orders of magnitude compared with conventional resonator-based approaches. In particular, a high-Q silica microsphere is employed to experimentally demonstrate the detection of single Bovine Serum Albumin proteins with a molecular weight of 66 kDalton at a signal-to-noise ratio of 16.8. On the other hand, the thesis focuses on the theoretical and experimental investigation of the generation of high-purity bright photon pairs in a silicon microdisk based on the cavity enhanced four-wave mixing. The device is able to produce multiple photon pairs at different wavelengths in the telecom band with a high spectral brightness of 6.24 x 107 pairs/s/mW 2/GHz and photon-pair correlation with a coincidence-to-accidental ratio of 1386+/-278 while pumped with a continuous-wave laser. Finally, an intriguing approach is proposed for dispersion dynamic tuning and micro-engineering, by taking advantage of the optical forces in nano-optomechanical structures. The proposed approach exhibits great potential for broad applications in dispersion-sensitive processes, which not only offer a new root towards versatile tunable nonlinear photonics, but may also open up a great avenue towards a new regime of nonlinear dynamics coupling between nonlinear optical and optomechanical effects.

Glomus fasciculatum Fungi as a Bio-convertor and Bio-activator of Inorganic and Organic P in Dual Symbiosis.

PubMed

Azmat, Rafia; Hamid, Neelofer; Moin, Sumeira; Saleem, Ailyan

2016-01-01

Dual symbiosis played an effective role in drought condition and temperature. Furthermore, performed services in absorption of water and solubilization of chief nutrients specially phosphorus for growth of plants. Phosphorous is essential for plant growth in any climatic condition because of central constituent of ATP providing chemical energy for all metabolic reactions of plants. The goal of this work was to monitor the growth of plant under three climatic conditions in comparison to control plant under Glomus fasciculatum inoculation related with adequate supply of phosphorous. Results demonstrated that Glomus fasciculatum (VAM) activates the solubilization of P into the anionic form H2PO4(-) which is highly consumable form by the plants. Minerals including P in soil most regularly solubilized for fixing in plants and continuously changed to highly soluble forms by reaction with inorganic or organic constituents of the soil which are activated in the presence of fungi for continuous availability. Experimental facts and nonstop growth of plants recommended that VAM fungi act as a bio-convertor and bio-activator of soil nutrients, especially of P and their hyphal interaction absorbs soil nutrients and activates insoluble P to soluble one for plant development. Continuous growth of 18 months old Conocarpus erectus L plant in dual symbiosis supports the proposed idea that phosphorus cycle exists during VAM inoculations, where soil reaction altered in presence of spores that help to solubilize the P which strengthens the plant, activates photo-biological activity and demonstrates the new function of VAM as a recycler for continues growth.

Third-party punishment as a costly signal of high continuation probabilities in repeated games.

PubMed

Jordan, Jillian J; Rand, David G

2017-05-21

Why do individuals pay costs to punish selfish behavior, even as third-party observers? A large body of research suggests that reputation plays an important role in motivating such third-party punishment (TPP). Here we focus on a recently proposed reputation-based account (Jordan et al., 2016) that invokes costly signaling. This account proposed that "trustworthy type" individuals (who are incentivized to cooperate with others) typically experience lower costs of TPP, and thus that TPP can function as a costly signal of trustworthiness. Specifically, it was argued that some but not all individuals face incentives to cooperate, making them high-quality and trustworthy interaction partners; and, because the same mechanisms that incentivize cooperation also create benefits for using TPP to deter selfish behavior, these individuals are likely to experience reduced costs of punishing selfishness. Here, we extend this conceptual framework by providing a concrete, "from-the-ground-up" model demonstrating how this process could work in the context of repeated interactions incentivizing both cooperation and punishment. We show how individual differences in the probability of future interaction can create types that vary in whether they find cooperation payoff-maximizing (and thus make high-quality partners), as well as in their net costs of TPP - because a higher continuation probability increases the likelihood of receiving rewards from the victim of the punished transgression (thus offsetting the cost of punishing). We also provide a simple model of dispersal that demonstrates how types that vary in their continuation probabilities can stably coexist, because the payoff from remaining in one's local environment (i.e. not dispersing) decreases with the number of others who stay. Together, this model demonstrates, from the group up, how TPP can serve as a costly signal of trustworthiness arising from exposure to repeated interactions. Copyright © 2017 Elsevier Ltd. All rights reserved.

40 CFR 63.2170 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I monitor and collect data to demonstrate continuous compliance? 63.2170 Section 63.2170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission...

40 CFR 63.5560 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true How do I monitor and collect data to demonstrate continuous compliance? 63.5560 Section 63.5560 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission...

40 CFR 63.6135 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true How do I monitor and collect data to demonstrate continuous compliance? 63.6135 Section 63.6135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission...

40 CFR 63.5355 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I monitor and collect data to demonstrate continuous compliance? 63.5355 Section 63.5355 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission...

40 CFR 63.5560 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I monitor and collect data to demonstrate continuous compliance? 63.5560 Section 63.5560 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission...

40 CFR 63.2170 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true How do I monitor and collect data to demonstrate continuous compliance? 63.2170 Section 63.2170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission...

40 CFR 63.6135 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I monitor and collect data to demonstrate continuous compliance? 63.6135 Section 63.6135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission...

Phonon Recycling for Ultrasensitive Kinetic Inductance Detectors

NASA Astrophysics Data System (ADS)

Zmuidzinas, Jonas

Initially proposed (Day et al. 2003; Zmuidzinas 2012) in 1999 by our Caltech/JPL group, and thanks to strong support from NASA, the superconducting (microwave) kinetic inductance detector (MKID or KID) technology continues to develop rapidly as it transitions into applications. The development effort worldwide is intensifying and NASA's continued support of KID development is essential in order to keep pace. Here we propose to investigate and demonstrate a new, low-TRL concept, which we call phonon recycling, that promises to open broad new avenues in KID design and performance. Briefly, phonon recycling allows the detector designer to tailor the responsivity and sensitivity of a KID to match the needs of the application by using geometry to restrict the rate at which recombination phonons are allowed to escape from the detector. In particular, phonon recycling should allow very low noise-equivalent power (NEP) to be achieved without requiring very low operating tem- peratures. Phonon recycling is analogous to the use of micromachined suspension legs to control the flow of heat in a bolometer, as measured by the thermal conductivity G. However, phonon recycling exploits the non-thermal distribution of recombination phonons as well as their very slow decay in crystals at low temperatures. These properties translate to geometrical and mechanical requirements for a phonon-recycled KID that are considerably more relaxed than for a bolometer operating at the same temperature and NEP. Our ultimate goal is to develop detector arrays suitable for a far-infrared (FIR) space mission, which will impose strict requirements on the array sensitivity, yield, uniformity, multiplexing density, etc. Through previous NASA support under the Strategic Astrophysics Technology (SAT) program, we have successfully demonstrated the MAKO submillimeter camera at the Caltech Submillimeter Observatory and have become familiar with these practical issues. If our demonstration of phonon recycling is successful, we will have a path for continuously adapting the high-background, high-NEP detectors we have demonstrated on the ground to the ultralow-NEP detectors needed for space.

High-power disk lasers: advances and applications

NASA Astrophysics Data System (ADS)

Havrilla, David; Ryba, Tracey; Holzer, Marco

2012-03-01

Though the genesis of the disk laser concept dates to the early 90's, the disk laser continues to demonstrate the flexibility and the certain future of a breakthrough technology. On-going increases in power per disk, and improvements in beam quality and efficiency continue to validate the genius of the disk laser concept. As of today, the disk principle has not reached any fundamental limits regarding output power per disk or beam quality, and offers numerous advantages over other high power resonator concepts, especially over monolithic architectures. With about 2,000 high power disk lasers installations, and a demand upwards of 1,000 lasers per year, the disk laser has proven to be a robust and reliable industrial tool. With advancements in running cost, investment cost and footprint, manufacturers continue to implement disk laser technology with more vigor than ever. This paper will explain recent advances in disk laser technology and process relevant features of the laser, like pump diode arrangement, resonator design and integrated beam guidance. In addition, advances in applications in the thick sheet area and very cost efficient high productivity applications like remote welding, remote cutting and cutting of thin sheets will be discussed.

Structural damage continuous monitoring by using a data driven approach based on principal component analysis and cross-correlation analysis

NASA Astrophysics Data System (ADS)

Camacho-Navarro, Jhonatan; Ruiz, Magda; Villamizar, Rodolfo; Mujica, Luis; Moreno-Beltrán, Gustavo; Quiroga, Jabid

2017-05-01

Continuous monitoring for damage detection in structural assessment comprises implementation of low cost equipment and efficient algorithms. This work describes the stages involved in the design of a methodology with high feasibility to be used in continuous damage assessment. Specifically, an algorithm based on a data-driven approach by using principal component analysis and pre-processing acquired signals by means of cross-correlation functions, is discussed. A carbon steel pipe section and a laboratory tower were used as test structures in order to demonstrate the feasibility of the methodology to detect abrupt changes in the structural response when damages occur. Two types of damage cases are studied: crack and leak for each structure, respectively. Experimental results show that the methodology is promising in the continuous monitoring of real structures.

Continuously Tunable, Polarization Controlled, Colour Palette Produced from Nanoscale Plasmonic Pixels.

PubMed

Balaur, Eugeniu; Sadatnajafi, Catherine; Kou, Shan Shan; Lin, Jiao; Abbey, Brian

2016-06-17

Colour filters based on nano-apertures in thin metallic films have been widely studied due to their extraordinary optical transmission and small size. These properties make them prime candidates for use in high-resolution colour displays and high accuracy bio-sensors. The inclusion of polarization sensitive plasmonic features in such devices allow additional control over the electromagnetic field distribution, critical for investigations of polarization induced phenomena. Here we demonstrate that cross-shaped nano-apertures can be used for polarization controlled color tuning in the visible range and apply fundamental theoretical models to interpret key features of the transmitted spectrum. Full color transmission was achieved by fine-tuning the periodicity of the apertures, whilst keeping the geometry of individual apertures constant. We demonstrate this effect for both transverse electric and magnetic fields. Furthermore we have been able to demonstrate the same polarization sensitivity even for nano-size, sub-wavelength sets of arrays, which is paramount for ultra-high resolution compact colour displays.

Continuously Tunable, Polarization Controlled, Colour Palette Produced from Nanoscale Plasmonic Pixels

PubMed Central

Balaur, Eugeniu; Sadatnajafi, Catherine; Kou, Shan Shan; Lin, Jiao; Abbey, Brian

2016-01-01

Colour filters based on nano-apertures in thin metallic films have been widely studied due to their extraordinary optical transmission and small size. These properties make them prime candidates for use in high-resolution colour displays and high accuracy bio-sensors. The inclusion of polarization sensitive plasmonic features in such devices allow additional control over the electromagnetic field distribution, critical for investigations of polarization induced phenomena. Here we demonstrate that cross-shaped nano-apertures can be used for polarization controlled color tuning in the visible range and apply fundamental theoretical models to interpret key features of the transmitted spectrum. Full color transmission was achieved by fine-tuning the periodicity of the apertures, whilst keeping the geometry of individual apertures constant. We demonstrate this effect for both transverse electric and magnetic fields. Furthermore we have been able to demonstrate the same polarization sensitivity even for nano-size, sub-wavelength sets of arrays, which is paramount for ultra-high resolution compact colour displays. PMID:27312072

Beyond the Coral Triangle: high genetic diversity and near panmixia in Singapore's populations of the broadcast spawning sea star Protoreaster nodosus

PubMed Central

Tay, Y. C.; Chng, M. W. P.; Sew, W. W. G.; Rheindt, F. E.; Tun, K. P. P.

2016-01-01

The Coral Triangle is widely considered the most important centre of marine biodiversity in Asia while areas on its periphery such as the South China Sea, have received much less interest. Here, we demonstrate that a small population of the knobbly sea star Protoreaster nodosus in Singapore has similarly high levels of genetic diversity as comparable Indonesian populations from the Coral Triangle. The high genetic diversity of this population is remarkable because it is maintained despite decades of continued anthropogenic disturbance. We postulate that it is probably due to broadcast spawning which is likely to maintain high levels of population connectivity. To test this, we analysed 6140 genome-wide single nucleotide polymorphism (SNP) loci for Singapore's populations and demonstrate a pattern of near panmixia. We here document a second case of high genetic diversity and low genetic structure for a broadcast spawner in Singapore, which suggests that such species have high resilience against anthropogenic disturbances. The study demonstrates the feasibility and power of using genome-wide SNPs for connectivity studies of marine invertebrates without a sequenced genome. PMID:27853600

5 CFR 890.1303 - Eligibility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL... Demonstration Project § 890.1303 Eligibility. (a) To enroll in the demonstration project, an individual must... benefit plans offered through the FEHB Program under the demonstration project. (d) When determining...

40 CFR 75.40 - General demonstration requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) CONTINUOUS EMISSION MONITORING Alternative Monitoring Systems § 75.40 General demonstration... continuous emission monitoring system may apply to the Administrator for approval of an alternative monitoring system (or system component) to determine average hourly emission data for SO2, NOX, and/or...

High-throughput electrical measurement and microfluidic sorting of semiconductor nanowires.

PubMed

Akin, Cevat; Feldman, Leonard C; Durand, Corentin; Hus, Saban M; Li, An-Ping; Hui, Ho Yee; Filler, Michael A; Yi, Jingang; Shan, Jerry W

2016-05-24

Existing nanowire electrical characterization tools not only are expensive and require sophisticated facilities, but are far too slow to enable statistical characterization of highly variable samples. They are also generally not compatible with further sorting and processing of nanowires. Here, we demonstrate a high-throughput, solution-based electro-orientation-spectroscopy (EOS) method, which is capable of automated electrical characterization of individual nanowires by direct optical visualization of their alignment behavior under spatially uniform electric fields of different frequencies. We demonstrate that EOS can quantitatively characterize the electrical conductivities of nanowires over a 6-order-of-magnitude range (10(-5) to 10 S m(-1), corresponding to typical carrier densities of 10(10)-10(16) cm(-3)), with different fluids used to suspend the nanowires. By implementing EOS in a simple microfluidic device, continuous electrical characterization is achieved, and the sorting of nanowires is demonstrated as a proof-of-concept. With measurement speeds two orders of magnitude faster than direct-contact methods, the automated EOS instrument enables for the first time the statistical characterization of highly variable 1D nanomaterials.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bierbach, Jana; Yeung, Mark; Eckner, Erich

Surface high-harmonic generation in the relativistic regime is demonstrated as a source of extreme ultra-violet (XUV) pulses with extended operation time. Relativistic high-harmonic generation is driven by a frequency-doubled high-power Ti:Sapphire laser focused to a peak intensity of 3·1019 W/cm2 onto spooling tapes. We demonstrate continuous operation over up to one hour runtime at a repetition rate of 1 Hz. Harmonic spectra ranging from 20 eV to 70 eV (62 nm to 18 nm) were consecutively recorded by an XUV spectrometer. An average XUV pulse energy in the µJ range is measured. With the presented setup, relativistic surface high-harmonic generationmore » becomes a powerful source of coherent XUV pulses that might enable applications in, e.g. attosecond laser physics and the seeding of free-electron lasers, when the laser issues causing 80-% pulse energy fluctuations are overcome.« less

Epitaxial Growth of Aligned and Continuous Carbon Nanofibers from Carbon Nanotubes.

PubMed

Lin, Xiaoyang; Zhao, Wei; Zhou, Wenbin; Liu, Peng; Luo, Shu; Wei, Haoming; Yang, Guangzhi; Yang, Junhe; Cui, Jie; Yu, Richeng; Zhang, Lina; Wang, Jiaping; Li, Qunqing; Zhou, Weiya; Zhao, Weisheng; Fan, Shoushan; Jiang, Kaili

2017-02-28

Exploiting the superior properties of nanomaterials at macroscopic scale is a key issue of nanoscience. Different from the integration strategy, "additive synthesis" of macroscopic structures from nanomaterial templates may be a promising choice. In this paper, we report the epitaxial growth of aligned, continuous, and catalyst-free carbon nanofiber thin films from carbon nanotube films. The fabrication process includes thickening of continuous carbon nanotube films by gas-phase pyrolytic carbon deposition and further graphitization of the carbon layer by high-temperature treatment. As-fabricated nanofibers in the film have an "annual ring" cross-section, with a carbon nanotube core and a graphitic periphery, indicating the templated growth mechanism. The absence of a distinct interface between the carbon nanotube template and the graphitic periphery further implies the epitaxial growth mechanism of the fiber. The mechanically robust thin film with tunable fiber diameters from tens of nanometers to several micrometers possesses low density, high electrical conductivity, and high thermal conductivity. Further extension of this fabrication method to enhance carbon nanotube yarns is also demonstrated, resulting in yarns with ∼4-fold increased tensile strength and ∼10-fold increased Young's modulus. The aligned and continuous features of the films together with their outstanding physical and chemical properties would certainly promote the large-scale applications of carbon nanofibers.

Experimental realization of spatially separated entanglement with continuous variables using laser pulse trains

PubMed Central

Zhang, Yun; Okubo, Ryuhi; Hirano, Mayumi; Eto, Yujiro; Hirano, Takuya

2015-01-01

Spatially separated entanglement is demonstrated by interfering two high-repetition squeezed pulse trains. The entanglement correlation of the quadrature amplitudes between individual pulses is interrogated. It is characterized in terms of the sufficient inseparability criterion with an optimum result of in the frequency domain and in the time domain. The quantum correlation is also observed when the two measurement stations are separated by a physical distance of 4.5 m, which is sufficiently large to demonstrate the space-like separation, after accounting for the measurement time. PMID:26278478

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkerson, Andrea M.; Sullivan, Gregory P.; Davis, Robert G.

Documentation of the Yuma Sector Border Patrol Area lighting LED trial demonstration continues to provide a better understanding of LED technology performance in a high ambient temperature and high solar radiation environment. Measured data at the project site showed illuminances changing more rapidly than anticipated. As previously predicted, the causes for these observed changes are mostly if not completely explained by dirt accumulation. The laboratory measurements showed not only the effect of dirt on lumen output, but also on the distribution of light exiting the luminaire.

Dark Solitons in High Velocity Waveguide Polariton Fluids.

PubMed

Walker, P M; Tinkler, L; Royall, B; Skryabin, D V; Farrer, I; Ritchie, D A; Skolnick, M S; Krizhanovskii, D N

2017-09-01

We study exciton-polariton nonlinear optical fluids in the high momentum waveguide regime for the first time. We demonstrate the formation of dark solitons with the expected dependence of width on fluid density for both main classes of soliton-forming fluid defects. The results are well described by numerical modeling of the fluid propagation. We deduce a continuous wave nonlinearity more than ten times that on picosecond time scales, arising due to interaction with the exciton reservoir.

40 CFR 60.2932 - How do I demonstrate continuous compliance with the emission limitations and the operating limits?

Code of Federal Regulations, 2013 CFR

2013-07-01

... listed in table 1 of this subpart and the procedures in 60.2922. (b) You must continuously monitor carbon... compliance with the emission limitations and the operating limits? 60.2932 Section 60.2932 Protection of... or After June 16, 2006 Continuous Compliance Requirements § 60.2932 How do I demonstrate continuous...

40 CFR 60.2932 - How do I demonstrate continuous compliance with the emission limitations and the operating limits?

Code of Federal Regulations, 2014 CFR

2014-07-01

... listed in table 1 of this subpart and the procedures in 60.2922. (b) You must continuously monitor carbon... compliance with the emission limitations and the operating limits? 60.2932 Section 60.2932 Protection of... or After June 16, 2006 Continuous Compliance Requirements § 60.2932 How do I demonstrate continuous...

Evidence of biogenic corrosion of titanium after exposure to a continuous culture of thiobacillus ferrooxidans grown in thiosulfate medium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horn, J M; Martin, S I; Masterson, B

2000-12-07

Experiments were undertaken to evaluate extreme conditions under which candidate materials intended for use in a proposed nuclear waste repository might be susceptible to corrosion by endogenous microorganisms. Thiobucillus ferrooxidans, a sulfur-oxidizing bacterium, was grown in continuous culture using thiosulfate as an energy source; thiosulfate is oxidized to sulfate as a metabolic endproduct by this organism. Culture conditions were optimized to produce a high-density, metabolically active culture throughout a period of long term incubation in the presence of Alloy 22 (a high nickel-based alloy) and Titanium grade 7 (Tigr7) material coupons. After seven months incubation under these conditions, material couponsmore » were withdrawn and analyzed by high resolution microscopy and energy dispersive x-ray analyses. Alloy 22 coupons showed no detectable signs of corrosion. Tigr7, however, demonstrated distinct roughening of the coupon surface, and [presumably solubilized and precipitated] titanium was detected on Alloy 22 coupons incubated in the same T. ferrooxiduns culture vessel. Control coupons of these materials incubated in sterile thiosulfate medium did not demonstrate any signs of corrosion, thus showing that observed corrosive effects were due to the T. ferrooxidans metabolic activities. T. ferrooxidans intermediates of thiosulfate oxidation or sulfate may have caused the corrosive effects observed on Tigr7.« less

Flexible Twist for Pitch Control in a High Altitude Long Endurance Aircraft with Nonlinear Response

DTIC Science & Technology

2008-12-01

Information dominance is the key motivator for employing high-altitude long-endurance (HALE) aircraft to provide continuous coverage in the theaters of operation A joined-wing configuration of such a craft gives the advantage of a platform for higher resolution sensors. Design challenges emerge with structural flexibility that arise from a long-endurance aircraft design. The goal was to demonstrate that scaling the nonlinear response of a full-scale finite element model of a high-altitude long-endurance (HALE) aircraft was possible if the model was aeroelastically and

California: A Case Study in the Loss of Affirmative Action. A Policy Report

ERIC Educational Resources Information Center

Gandara, Patricia

2012-01-01

This paper briefly reviews the various efforts undertaken by the University of California to maintain diversity in the institution, and especially at its highly competitive flagship campuses, UCLA and Berkeley, in the face of the loss of affirmative action during the mid-1990s. It demonstrates the continuing decline in representation of…

Development of phytoplankton communities and common off-flavors in a biofloc technology system used for the culture of channel catfish (Ictalurus punctatus)

USDA-ARS?s Scientific Manuscript database

The use of biofloc technology production systems continues to increase in the aquaculture industry worldwide. Recent research demonstrated that outdoor biofloc systems can be used to produce high yields of channel catfish (Ictalurus punctatus). However, studies have not yet been performed to deter...

NLO BFKL and Anomalous Dimensions of Light-Ray Operators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balitsky, Ian

2014-01-01

The anomalous dimensions of light-ray operators of twist two are obtained by analytical continuation of the anomalous dimensions of corresponding local operators. I demonstrate that the asymptotics of these anomalous dimensions at the "BFKL point" j → 1 can be obtained by comparing the light-cone operator expansion with the high-energy expansion in Wilson lines.

Characterization of MoS2-Graphene Composites for High-Performance Coin Cell Supercapacitors.

PubMed

Bissett, Mark A; Kinloch, Ian A; Dryfe, Robert A W

2015-08-12

Two-dimensional materials, such as graphene and molybdenum disulfide (MoS2), can greatly increase the performance of electrochemical energy storage devices because of the combination of high surface area and electrical conductivity. Here, we have investigated the performance of solution exfoliated MoS2 thin flexible membranes as supercapacitor electrodes in a symmetrical coin cell arrangement using an aqueous electrolyte (Na2SO4). By adding highly conductive graphene to form nanocomposite membranes, it was possible to increase the specific capacitance by reducing the resistivity of the electrode and altering the morphology of the membrane. With continued charge/discharge cycles the performance of the membranes was found to increase significantly (up to 800%), because of partial re-exfoliation of the layered material with continued ion intercalation, as well as increasing the specific capacitance through intercalation pseudocapacitance. These results demonstrate a simple and scalable application of layered 2D materials toward electrochemical energy storage.

Multi-category micro-milling tool wear monitoring with continuous hidden Markov models

NASA Astrophysics Data System (ADS)

Zhu, Kunpeng; Wong, Yoke San; Hong, Geok Soon

2009-02-01

In-process monitoring of tool conditions is important in micro-machining due to the high precision requirement and high tool wear rate. Tool condition monitoring in micro-machining poses new challenges compared to conventional machining. In this paper, a multi-category classification approach is proposed for tool flank wear state identification in micro-milling. Continuous Hidden Markov models (HMMs) are adapted for modeling of the tool wear process in micro-milling, and estimation of the tool wear state given the cutting force features. For a noise-robust approach, the HMM outputs are connected via a medium filter to minimize the tool state before entry into the next state due to high noise level. A detailed study on the selection of HMM structures for tool condition monitoring (TCM) is presented. Case studies on the tool state estimation in the micro-milling of pure copper and steel demonstrate the effectiveness and potential of these methods.

SERT 2 thruster space restart, 1974

NASA Technical Reports Server (NTRS)

Kerslake, W. R.; Finke, R. C.

1975-01-01

The results of testing the flight thrusters on the SERT spacecraft during the 1974 test period are presented. The most notable result was the clearing of the high voltage short from thruster 2 and the successful stable operation of its ion beam. Test periods were limited to 70 minutes or less by earth eclipse of the spacecraft solar array and by ground station coverage limitations. Thruster 2 was restarted 26 times with an ion beam produced 21 times. The high voltage short remains in thruster 1, but the cathodes were restarted 12 times to demonstrate continued restart capability. The propellant feed systems, power processors, and spacecraft ancillary equipment were demonstrated to be functional after 4 1/2 years in space. In addition to the thruster tests, a neutralizer cathode was operated separately to demonstrate that the potential level of a spacecraft could be controlled by the neutralizer alone.

A spectrally tunable all-graphene-based flexible field-effect light-emitting device

NASA Astrophysics Data System (ADS)

Wang, Xiaomu; Tian, He; Mohammad, Mohammad Ali; Li, Cheng; Wu, Can; Yang, Yi; Ren, Tian-Ling

2015-07-01

The continuous tuning of the emission spectrum of a single light-emitting diode (LED) by an external electrical bias is of great technological significance as a crucial property in high-quality displays, yet this capability has not been demonstrated in existing LEDs. Graphene, a tunable optical platform, is a promising medium to achieve this goal. Here we demonstrate a bright spectrally tunable electroluminescence from blue (~450 nm) to red (~750 nm) at the graphene oxide/reduced-graphene oxide interface. We explain the electroluminescence results from the recombination of Poole-Frenkel emission ionized electrons at the localized energy levels arising from semi-reduced graphene oxide, and holes from the top of the π band. Tuning of the emission wavelength is achieved by gate modulation of the participating localized energy levels. Our demonstration of current-driven tunable LEDs not only represents a method for emission wavelength tuning but also may find applications in high-quality displays.

Electrically pumped continuous wave quantum dot lasers epitaxially grown on patterned, on-axis (001) Si

DOE Office of Scientific and Technical Information (OSTI.GOV)

Norman, Justin; Kennedy, M. J.; Selvidge, Jennifer

High performance III-V lasers at datacom and telecom wavelengths on on-axis (001) Si are needed for scalable datacenter interconnect technologies. We demonstrate electrically injected quantum dot lasers grown on on-axis (001) Si patterned with {111} v-grooves lying in the [110] direction. No additional Ge buffers or substrate miscut was used. The active region consists of five InAs/InGaAs dot-in-a-well layers. Here, we achieve continuous wave lasing with thresholds as low as 36 mA and operation up to 80°C.

Electrically pumped continuous wave quantum dot lasers epitaxially grown on patterned, on-axis (001) Si

DOE PAGES

Norman, Justin; Kennedy, M. J.; Selvidge, Jennifer; ...

2017-02-14

High performance III-V lasers at datacom and telecom wavelengths on on-axis (001) Si are needed for scalable datacenter interconnect technologies. We demonstrate electrically injected quantum dot lasers grown on on-axis (001) Si patterned with {111} v-grooves lying in the [110] direction. No additional Ge buffers or substrate miscut was used. The active region consists of five InAs/InGaAs dot-in-a-well layers. Here, we achieve continuous wave lasing with thresholds as low as 36 mA and operation up to 80°C.

Minimum fuel control of a vehicle with a continuously variable transmission. [control system simulation

NASA Technical Reports Server (NTRS)

Burghart, J. H.; Donoghue, J. F.

1980-01-01

The design and evaluation of a control system for a sedan with a heat engine and a continuously variable transmission, is considered in a effort to minimize fuel consumption and achieve satisfactory dynamic response of vehicle variables as the vehicle is driven over a standard driving cycle. Even though the vehicle system was highly nonlinear, attention was restricted to linear control algorithms which could be easily understood and implemented demonstrated by simulation. Simulation results also revealed that the vehicle could exhibit unexpected dynamic behavior which must be taken into account in any control system design.

Maximising biohydrogen yields via continuous electrochemical hydrogen removal and carbon dioxide scrubbing.

PubMed

Massanet-Nicolau, Jaime; Jones, Rhys Jon; Guwy, Alan; Dinsdale, Richard; Premier, Giuliano; Mulder, Martijn J J

2016-10-01

The use of electrochemical hydrogen removal (EHR) together with carbon dioxide removal (CDR) was demonstrated for the first time using a continuous hydrogen producing fermenter. CDR alone was found to increase hydrogen yields from 0.07molH2molhexose to 0.72molH2molhexose. When CDR was combined with EHR, hydrogen yields increased further to 1.79molH2molhexose. The pattern of carbohydrate utilisation and volatile fatty acid (VFA) production are consistent with the hypothesis that increased yields are the result of relieving end product inhibition and inhibition of microbial hydrogen consumption. In situ removal of hydrogen and carbon dioxide as demonstrated here not only increase hydrogen yield but also produces a relatively pure product gas and unlike other approaches can be used to enhance conventional, mesophilic, CSTR type fermentation of low grade/high solids biomass. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

Telephone-quality pathological speech classification using empirical mode decomposition.

PubMed

Kaleem, M F; Ghoraani, B; Guergachi, A; Krishnan, S

2011-01-01

This paper presents a computationally simple and effective methodology based on empirical mode decomposition (EMD) for classification of telephone quality normal and pathological speech signals. EMD is used to decompose continuous normal and pathological speech signals into intrinsic mode functions, which are analyzed to extract physically meaningful and unique temporal and spectral features. Using continuous speech samples from a database of 51 normal and 161 pathological speakers, which has been modified to simulate telephone quality speech under different levels of noise, a linear classifier is used with the feature vector thus obtained to obtain a high classification accuracy, thereby demonstrating the effectiveness of the methodology. The classification accuracy reported in this paper (89.7% for signal-to-noise ratio 30 dB) is a significant improvement over previously reported results for the same task, and demonstrates the utility of our methodology for cost-effective remote voice pathology assessment over telephone channels.

40 CFR 63.7114 - How do I demonstrate initial compliance with the emission limitations standard?

Code of Federal Regulations, 2012 CFR

2012-07-01

... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Lime Manufacturing Plants Testing and Initial Compliance Requirements § 63.7114 How do I demonstrate...

Continuous extraction of phenolic compounds from pomegranate peel using high voltage electrical discharge.

PubMed

Xi, Jun; He, Lang; Yan, Liang-Gong

2017-09-01

Pomegranate peel, a waste generated from fruit processing industry, is a potential source of phenolic compounds that are known for their anti-oxidative properties. In this study, a continuous high voltage electrical discharge (HVED) extraction system was for the first time designed and optimized for phenolic compounds from pomegranate peel. The optimal conditions for HVED were: flow rate of materials 12mL/min, electrodes gap distance 3.1mm (corresponding to 29kV/cm of electric field intensity) and liquid to solid ratio 35mL/g. Under these conditions, the experimental yield of phenolic compounds was 196.7±6.4mg/g, which closely agreed with the predicted value (199.83mg/g). Compared with the warm water maceration, HVED method possessed higher efficiency for the extraction of phenolic compounds. The results demonstrated that HVED technique could be a very effective method for continuous extraction of natural compounds. Copyright © 2017 Elsevier Ltd. All rights reserved.

Growth and lipid accumulation characteristics of Scenedesmus obliquus in semi-continuous cultivation outdoors for biodiesel feedstock production.

PubMed

Feng, Pingzhong; Yang, Kang; Xu, Zhongbin; Wang, Zhongming; Fan, Lu; Qin, Lei; Zhu, Shunni; Shang, Changhua; Chai, Peng; Yuan, Zhenhong; Hu, Lei

2014-12-01

In an effort to identify suitable microalgal species for biodiesel production, seven species were isolated from various habitats and their growth characteristics were compared. The results demonstrated that a green alga Scenedesmus obliquus could grow more rapidly and synthesize more lipids than other six microalgal strains. S. obliquus grew well both indoors and outdoors, and reached higher μmax indoors than that outdoors. However, the cells achieved higher dry weight (4.36 g L(-1)), lipid content (49.6%) and productivity (183 mg L(-1) day(-1)) outdoors than in indoor cultures. During the 61 days semi-continuous cultivation outdoors, high biomass productivities (450-550 mg L(-1) day(-1)) and μmax (1.05-1.44 day(-1)) were obtained. The cells could also achieve high lipid productivities (151-193 mg L(-1) day(-1)). These results indicated that S. obliquus was promising for lipids production in semi-continuous cultivation outdoors. Copyright © 2014 Elsevier Ltd. All rights reserved.

Testing of a compact 10-Gbps Lasercomm system for maritime platforms

NASA Astrophysics Data System (ADS)

Juarez, Juan C.; Souza, Katherine T.; Nicholes, Dustin D.; Riggins, James L.; Tomey, Hala J.; Venkat, Radha A.

2017-08-01

Lasercomm technology continues to be of interest for many applications both in the commercial and defense sectors because of its potential to provide high bandwidth communications that are secure without the need for RF spectrum management. Over the last decade, terrestrial Lasercomm development has progressed from initial experiments in the lab through field demonstrations in airborne and maritime environments. While these demonstrations have shown high capability levels, the complexity, size, weight, and power of the systems has slowed transition into fielded systems. This paper presents field test results of a recently developed maritime Lasercomm terminal and modem architecture with a compact form factor for enabling robust, 10-Gbps class data transport over highly scintillated links as found in terrestrial applications such as air-to-air, air-to-surface, and surface-to-surface links.

Clinical studies of the High-Intensity Narrow-Spectrum light Environmental Decontamination System (HINS-light EDS), for continuous disinfection in the burn unit inpatient and outpatient settings.

PubMed

Bache, Sarah E; Maclean, Michelle; MacGregor, Scott J; Anderson, John G; Gettinby, George; Coia, John E; Taggart, Ian

2012-02-01

Infections are the leading cause of morbidity and mortality in burn patients and prevention of contamination from exogenous sources including the hospital environment is becoming increasingly emphasised. The High-Intensity Narrow-Spectrum light Environmental Decontamination System (HINS-light EDS) is bactericidal yet safe for humans, allowing continuous disinfection of the environment surrounding burn patients. Environmental samples were collected from inpatient isolation rooms and the outpatient clinic in the burn unit, and comparisons were then made between the bacterial contamination levels observed with and without use of the HINS-light EDS. Over 1000 samples were taken. Inpatient studies, with sampling carried out at 0800 h, demonstrated a significant reduction in the average number of bacterial colonies following HINS-light EDS use of between 27% and 75%, (p<0.05). There was more variation when samples were taken at times of increased activity in the room. Outpatient studies during clinics demonstrated a 61% efficacy in the reduction of bacterial contamination on surfaces throughout the room during the course of a clinic (p=0.02). The results demonstrate that use of the HINS-light EDS allows efficacious bacterial reductions over and above that achieved by standard cleaning and infection control measures in both inpatient and outpatient settings in the burn unit. Copyright © 2011 Elsevier Ltd and ISBI. All rights reserved.

Ringing phenomenon based whispering-gallery-mode sensing

PubMed Central

Ye, Ming-Yong; Shen, Mei-Xia; Lin, Xiu-Min

2016-01-01

Highly sensitive sensing is one of the most important applications of whispering-gallery-mode (WGM) microresonators, which is usually accomplished through a tunable continuous-wave laser sweeping over a whispering-gallery mode with the help of a fiber taper in a relative slow speed. It is known that if a tunable continuous-wave laser sweeps over a high quality whispering-gallery mode in a fast speed, a ringing phenomenon will be observed. The ringing phenomenon in WGM microresonators is mainly used to measure the Q factors and mode-coupling strengths. Here we experimentally demonstrate that the WGM sensing can be achieved based on the ringing phenomenon. This kind of sensing is accomplished in a much shorter time and is immune to the noise caused by the laser wavelength drift. PMID:26796871

5 CFR 890.1305 - Termination and cancellation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Section 890.1305 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... Health Benefits Program Demonstration Project § 890.1305 Termination and cancellation. (a) If an enrolled... demonstration area, he or she will continue to be eligible to participate in the demonstration project. If the...

Test and evaluation of the HIDEC engine uptrim algorithm

NASA Technical Reports Server (NTRS)

Ray, R. J.; Myers, L. P.

1986-01-01

The highly integrated digital electronic control (HIDEC) program will demonstrate and evaluate the improvements in performance and mission effectiveness that result from integrated engine-airframe control systems. Performance improvements will result from an adaptive engine stall margin mode, a highly integrated mode that uses the airplane flight conditions and the resulting inlet distortion to continuously compute engine stall margin. When there is excessive stall margin, the engine is uptrimmed for more thrust by increasing engine pressure ratio (EPR). The EPR uptrim logic has been evaluated and implemented into computer simulations. Thrust improvements over 10 percent are predicted for subsonic flight conditions. The EPR uptrim was successfully demonstrated during engine ground tests. Test results verify model predictions at the conditions tested.

40 CFR 63.10420 - How do I demonstrate continuous compliance with the management practice requirements?

Code of Federal Regulations, 2010 CFR

2010-07-01

... compliance with the management practice requirements? 63.10420 Section 63.10420 Protection of Environment... continuous compliance with the management practice requirements? For each sterilization unit not equipped with an air pollution control device, you must demonstrate continuous compliance with the management...

40 CFR 63.6006 - How do I demonstrate continuous compliance with the emission limits for tire cord production...

Code of Federal Regulations, 2010 CFR

2010-07-01

... compliance with the emission limits for tire cord production affected sources? 63.6006 Section 63.6006... Hazardous Air Pollutants: Rubber Tire Manufacturing Continuous Compliance Requirements for Tire Cord... tire cord production affected sources? (a) You must demonstrate continuous compliance with each...

40 CFR 63.4741 - How do I demonstrate initial compliance with the emission limitations?

Code of Federal Regulations, 2013 CFR

2013-07-01

... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants... operating limits or work practice standards required in §§ 63.4692 and 63.4693, respectively. To demonstrate...

Sharp-Tip Silver Nanowires Mounted on Cantilevers for High-Aspect-Ratio High-Resolution Imaging.

PubMed

Ma, Xuezhi; Zhu, Yangzhi; Kim, Sanggon; Liu, Qiushi; Byrley, Peter; Wei, Yang; Zhang, Jin; Jiang, Kaili; Fan, Shoushan; Yan, Ruoxue; Liu, Ming

2016-11-09

Despite many efforts to fabricate high-aspect-ratio atomic force microscopy (HAR-AFM) probes for high-fidelity, high-resolution topographical imaging of three-dimensional (3D) nanostructured surfaces, current HAR probes still suffer from unsatisfactory performance, low wear-resistivity, and extravagant prices. The primary objective of this work is to demonstrate a novel design of a high-resolution (HR) HAR AFM probe, which is fabricated through a reliable, cost-efficient benchtop process to precisely implant a single ultrasharp metallic nanowire on a standard AFM cantilever probe. The force-displacement curve indicated that the HAR-HR probe is robust against buckling and bending up to 150 nN. The probes were tested on polymer trenches, showing a much better image fidelity when compared with standard silicon tips. The lateral resolution, when scanning a rough metal thin film and single-walled carbon nanotubes (SW-CNTs), was found to be better than 8 nm. Finally, stable imaging quality in tapping mode was demonstrated for at least 15 continuous scans indicating high resistance to wear. These results demonstrate a reliable benchtop fabrication technique toward metallic HAR-HR AFM probes with performance parallel or exceeding that of commercial HAR probes, yet at a fraction of their cost.

Purification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography

PubMed Central

Dutta, Amit K.; Tran, Travis; Napadensky, Boris; Teella, Achyuta; Brookhart, Gary; Ropp, Philip A.; Zhang, Ada W.; Tustian, Andrew D.; Zydney, Andrew L.; Shinkazh, Oleg

2015-01-01

Recent studies using simple model systems have demonstrated that Continuous Countercurrent Tangential Chromatography (CCTC) has the potential to overcome many of the limitations of conventional Protein A chromatography using packed columns. The objective of this work was to optimize and implement a CCTC system for monoclonal antibody purification from clarified Chinese Hamster Ovary (CHO) cell culture fluid using a commercial Protein A resin. Several improvements were introduced to the previous CCTC system including the use of retentate pumps to maintain stable resin concentrations in the flowing slurry, the elimination of a slurry holding tank to improve productivity, and the introduction of an “after binder” to the binding step to increase antibody recovery. A kinetic binding model was developed to estimate the required residence times in the multi-stage binding step to optimize yield and productivity. Data were obtained by purifying two commercial antibodies from two different manufactures, one with low titer (~0.67 g/L) and one with high titer (~6.9 g/L), demonstrating the versatility of the CCTC system. Host cell protein removal, antibody yields and purities were similar to that obtained with conventional column chromatography; however, the CCTC system showed much higher productivity. These results clearly demonstrate the capabilities of continuous countercurrent tangential chromatography for the commercial purification of monoclonal antibody products. PMID:25747172

Purification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography.

PubMed

Dutta, Amit K; Tran, Travis; Napadensky, Boris; Teella, Achyuta; Brookhart, Gary; Ropp, Philip A; Zhang, Ada W; Tustian, Andrew D; Zydney, Andrew L; Shinkazh, Oleg

2015-11-10

Recent studies using simple model systems have demonstrated that continuous countercurrent tangential chromatography (CCTC) has the potential to overcome many of the limitations of conventional Protein A chromatography using packed columns. The objective of this work was to optimize and implement a CCTC system for monoclonal antibody purification from clarified Chinese Hamster Ovary (CHO) cell culture fluid using a commercial Protein A resin. Several improvements were introduced to the previous CCTC system including the use of retentate pumps to maintain stable resin concentrations in the flowing slurry, the elimination of a slurry holding tank to improve productivity, and the introduction of an "after binder" to the binding step to increase antibody recovery. A kinetic binding model was developed to estimate the required residence times in the multi-stage binding step to optimize yield and productivity. Data were obtained by purifying two commercial antibodies from two different manufactures, one with low titer (∼ 0.67 g/L) and one with high titer (∼ 6.9 g/L), demonstrating the versatility of the CCTC system. Host cell protein removal, antibody yields and purities were similar to those obtained with conventional column chromatography; however, the CCTC system showed much higher productivity. These results clearly demonstrate the capabilities of continuous countercurrent tangential chromatography for the commercial purification of monoclonal antibody products. Copyright © 2015 Elsevier B.V. All rights reserved.

Continuous variable quantum key distribution with modulated entangled states.

PubMed

Madsen, Lars S; Usenko, Vladyslav C; Lassen, Mikael; Filip, Radim; Andersen, Ulrik L

2012-01-01

Quantum key distribution enables two remote parties to grow a shared key, which they can use for unconditionally secure communication over a certain distance. The maximal distance depends on the loss and the excess noise of the connecting quantum channel. Several quantum key distribution schemes based on coherent states and continuous variable measurements are resilient to high loss in the channel, but are strongly affected by small amounts of channel excess noise. Here we propose and experimentally address a continuous variable quantum key distribution protocol that uses modulated fragile entangled states of light to greatly enhance the robustness to channel noise. We experimentally demonstrate that the resulting quantum key distribution protocol can tolerate more noise than the benchmark set by the ideal continuous variable coherent state protocol. Our scheme represents a very promising avenue for extending the distance for which secure communication is possible.

Detuned surface plasmon resonance scattering of gold nanorods for continuous wave multilayered optical recording and readout.

PubMed

Taylor, Adam B; Kim, Jooho; Chon, James W M

2012-02-27

In a multilayered structure of absorptive optical recording media, continuous-wave laser operation is highly disadvantageous due to heavy beam extinction. For a gold nanorod based recording medium, the narrow surface plasmon resonance (SPR) profile of gold nanorods enables the variation of extinction through mulilayers by a simple detuning of the readout wavelength from the SPR peak. The level of signal extinction through the layers can then be greatly reduced, resulting more efficient readout at deeper layers. The scattering signal strength may be decreased at the detuned wavelength, but balancing these two factors results an optimal scattering peak wavelength that is specific to each layer. In this paper, we propose to use detuned SPR scattering from gold nanorods as a new mechanism for continuous-wave readout scheme on gold nanorod based multilayered optical storage. Using this detuned scattering method, readout using continuous-wave laser is demonstrated on a 16 layer optical recording medium doped with heavily distributed, randomly oriented gold nanorods. Compared to SPR on-resonant readout, this method reduced the required readout power more than one order of magnitude, with only 60 nm detuning from SPR peak. The proposed method will be highly beneficial to multilayered optical storage applications as well as applications using a continuous medium doped heavily with plasmonic nanoparticles.

Semi-continuous anaerobic digestion of extruded OFMSW: Process performance and energetics evaluation.

PubMed

Mu, Lan; Zhang, Lei; Zhu, Kongyun; Ma, Jiao; Li, Aimin

2018-01-01

Recently, extrusion press treatment shows some promising advantages for effectively separating of organic fraction of municipal solid waste (OFMSW) from the mixed MSW, which is critical for their following high-efficiency treatment. In this study, an extruded OFMSW obtained from a demonstrated MSW treatment plant was characterized, and submitted to a series of semi-continuous anaerobic experiments to examine its biodegradability and process stability. The results indicated that the extruded OFMSW was a desirable substrate with a high biochemical methane potential (BMP), balanced nutrients and reliable stability. For increasing organic loading rates (OLRs), feeding higher volatile solid (VS) contents in feedstock was much better than shortening the hydraulic retention times (HRTs), while excessively high contents caused a low biodegradability due to the mass transfer limitation. For energetics evaluation, a high electricity output of 129.19-156.37kWh/ton raw MSW was obtained, which was further improved by co-digestion with food waste. Copyright © 2017 Elsevier Ltd. All rights reserved.

Defective TiO 2 with high photoconductive gain for efficient and stable planar heterojunction perovskite solar cells

DOE PAGES

Li, Yanbo; Cooper, Jason K.; Liu, Wenjun; ...

2016-08-18

Formation of planar heterojunction perovskite solar cells exhibiting both high efficiency and stability under continuous operation remains a challenge. Here, we show this can be achieved by using a defective TiO 2 thin film as the electron transport layer. TiO 2 layers with native defects are deposited by electron beam evaporation in an oxygen-deficient environment. Deep-level hole traps are introduced in the TiO 2 layers and contribute to a high photoconductive gain and reduced photocatalytic activity. The high photoconductivity of the TiO 2 electron transport layer leads to improved efficiency for the fabricated planar devices. A maximum power conversion efficiencymore » of 19.0% and an average PCE of 17.5% are achieved. In addition, the reduced photocatalytic activity of the TiO 2 layer leads to enhanced long-Term stability for the planar devices. Under continuous operation near the maximum power point, an efficiency of over 15.4% is demonstrated for 100 h.« less

A High Temperature Silicon Carbide mosfet Power Module With Integrated Silicon-On-Insulator-Based Gate Drive

DOE PAGES

Wang, Zhiqiang; Shi, Xiaojie; Tolbert, Leon M.; ...

2014-04-30

Here we present a board-level integrated silicon carbide (SiC) MOSFET power module for high temperature and high power density application. Specifically, a silicon-on-insulator (SOI)-based gate driver capable of operating at 200°C ambient temperature is designed and fabricated. The sourcing and sinking current capability of the gate driver are tested under various ambient temperatures. Also, a 1200 V/100 A SiC MOSFET phase-leg power module is developed utilizing high temperature packaging technologies. The static characteristics, switching performance, and short-circuit behavior of the fabricated power module are fully evaluated at different temperatures. Moreover, a buck converter prototype composed of the SOI gate drivermore » and SiC power module is built for high temperature continuous operation. The converter is operated at different switching frequencies up to 100 kHz, with its junction temperature monitored by a thermosensitive electrical parameter and compared with thermal simulation results. The experimental results from the continuous operation demonstrate the high temperature capability of the power module at a junction temperature greater than 225°C.« less

RESULTS OF THE SEPTEMBER 1997 DOE/EPA DEMONSTRATION OF MULTIMETAL CONTINUOUS EMISSION MONITORING TECHNOLOGIES

EPA Science Inventory

In September 1997, the U.S. Department of Energy (DOE) and U.S. Environmental Protection Agency (EPA) co-sponsored a demonstration of several multimetal continuous emission monitos (CEMs). The demonstration, performed at the EPA National Risk Management Research Laboratory, Air P...

Synthesis of thermally stable polypyrazoles, polypyrimidines and other heteroaromatic polymers

NASA Technical Reports Server (NTRS)

Bass, R. G.

1986-01-01

As part of a continuing effort to prepare high performance-high temperature polymers for functional and structural applications, the reactions of aromatic dipropynones with aromatic dihydrazine, aromatic dithiols, and aromatic diamidines to provide polypyrazoles, polyenonesulfides, and polypyrimidines respectively were investigated. During the past year, it was demonstrated that polypyrazoles and polyenonesulfides may be prepared by the proposed procedures. However, the preparation of polypyrimidines was not achieved. The preparation and characterization of some polypyrazolones by reaction or aromatic dihydrazines with an activated diacetylenic diester was achieved.

Robustness of quantum key distribution with discrete and continuous variables to channel noise

NASA Astrophysics Data System (ADS)

Lasota, Mikołaj; Filip, Radim; Usenko, Vladyslav C.

2017-06-01

We study the robustness of quantum key distribution protocols using discrete or continuous variables to the channel noise. We introduce the model of such noise based on coupling of the signal to a thermal reservoir, typical for continuous-variable quantum key distribution, to the discrete-variable case. Then we perform a comparison of the bounds on the tolerable channel noise between these two kinds of protocols using the same noise parametrization, in the case of implementation which is perfect otherwise. Obtained results show that continuous-variable protocols can exhibit similar robustness to the channel noise when the transmittance of the channel is relatively high. However, for strong loss discrete-variable protocols are superior and can overcome even the infinite-squeezing continuous-variable protocol while using limited nonclassical resources. The requirement on the probability of a single-photon production which would have to be fulfilled by a practical source of photons in order to demonstrate such superiority is feasible thanks to the recent rapid development in this field.

Role of hydrogen in the chemical vapor deposition growth of MoS2 atomic layers

NASA Astrophysics Data System (ADS)

Li, Xiao; Li, Xinming; Zang, Xiaobei; Zhu, Miao; He, Yijia; Wang, Kunlin; Xie, Dan; Zhu, Hongwei

2015-04-01

Hydrogen plays a crucial role in the chemical vapor deposition (CVD) growth of graphene. Here, we have revealed the roles of hydrogen in the two-step CVD growth of MoS2. Our study demonstrates that hydrogen acts as the following: (i) an inhibitor of the thermal-induced etching effect in the continuous film growth process; and (ii) a promoter of the desulfurization reaction by decreasing the S/Mo atomic ratio and the oxidation reaction of the obtained MoSx (0 < x < 2) films. A high hydrogen content of more than 100% in argon forms nano-sized circle-like defects and damages the continuity and uniformity of the film. Continuous MoS2 films with a high crystallinity and a nearly perfect S/Mo atomic ratio were finally obtained after sulfurization annealing with a hydrogen content in the range of 20%-80%. This insightful understanding reveals the crucial roles of hydrogen in the CVD growth of MoS2 and paves the way for the controllable synthesis of two-dimensional materials.Hydrogen plays a crucial role in the chemical vapor deposition (CVD) growth of graphene. Here, we have revealed the roles of hydrogen in the two-step CVD growth of MoS2. Our study demonstrates that hydrogen acts as the following: (i) an inhibitor of the thermal-induced etching effect in the continuous film growth process; and (ii) a promoter of the desulfurization reaction by decreasing the S/Mo atomic ratio and the oxidation reaction of the obtained MoSx (0 < x < 2) films. A high hydrogen content of more than 100% in argon forms nano-sized circle-like defects and damages the continuity and uniformity of the film. Continuous MoS2 films with a high crystallinity and a nearly perfect S/Mo atomic ratio were finally obtained after sulfurization annealing with a hydrogen content in the range of 20%-80%. This insightful understanding reveals the crucial roles of hydrogen in the CVD growth of MoS2 and paves the way for the controllable synthesis of two-dimensional materials. Electronic supplementary information (ESI) available: Low-magnification optical images; Raman spectra of 0% and 5% H2 samples; AFM characterization; Schematic of the film before and after sulfurization annealing; Schematic illustrations of two typical Raman-active phonon modes (E12g, A1g); Raman (mapping) spectra for 40% and 80% H2 samples before and after sulfurization annealing; PL spectra. See DOI: 10.1039/c5nr00904a

Long-term operation of surface high-harmonic generation from relativistic oscillating mirrors using a spooling tape

DOE PAGES

Bierbach, Jana; Yeung, Mark; Eckner, Erich; ...

2015-05-01

Surface high-harmonic generation in the relativistic regime is demonstrated as a source of extreme ultra-violet (XUV) pulses with extended operation time. Relativistic high-harmonic generation is driven by a frequency-doubled high-power Ti:Sapphire laser focused to a peak intensity of 3·1019 W/cm2 onto spooling tapes. We demonstrate continuous operation over up to one hour runtime at a repetition rate of 1 Hz. Harmonic spectra ranging from 20 eV to 70 eV (62 nm to 18 nm) were consecutively recorded by an XUV spectrometer. An average XUV pulse energy in the µJ range is measured. With the presented setup, relativistic surface high-harmonic generationmore » becomes a powerful source of coherent XUV pulses that might enable applications in, e.g. attosecond laser physics and the seeding of free-electron lasers, when the laser issues causing 80-% pulse energy fluctuations are overcome.« less

Overview of NASA GRC Stirling Technology Development

NASA Technical Reports Server (NTRS)

Schreiber, Jeffrey G.; Thieme, Lanny G.

2004-01-01

The Stirling Radioisotope Generator (SRG) is currently being developed by Lockheed Martin Astronautics (LMA) under contract to the Department of Energy (DOE). The generator will be a high efficiency electric power source for NASA Space Science missions with the ability to operate in vacuum or in an atmosphere such as on Mars. High efficiency is obtained through the use of free-piston Stirling power conversion. Power output will be greater than 100 watts at the beginning of life with the decline in power largely due to the decay of the plutonium heat source. In support of the DOE SRG project, the NASA Glenn Research Center (GRC) has established a technology effort to provide data to ensure a successful transition to flight for what will be the first dynamic power system in space. Initially, a limited number of areas were selected for the effort, however this is now being expanded to more thoroughly cover key technical issues. There is also an advanced technology effort that is complementary to the near-term technology effort. Many of the tests use the 55-We Technology Demonstration Convertor (TDC). There have been multiple controller tests to support the LMA flight controller design effort. Preparation is continuing for a thermal/vacuum system demonstration. A pair of flight prototype TDC s have been placed on continuous operation. Heater head life assessment continues, with the material data being refined and the analysis moving toward the system perspective. Magnet aging tests continue to characterize any possible aging in the strength or demagnetization resistance of the magnets in the linear alternator. A reliability effort has been initiated to help guide the development activities with focus on the key components and subsystems. This paper will provide an overview of some of the GRC technical efforts, including the status, and a description of future efforts.

40 CFR 60.5415 - How do I demonstrate continuous compliance with the standards for my gas well affected facility...

Code of Federal Regulations, 2014 CFR

2014-07-01

... plants? 60.5415 Section 60.5415 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... used to reduce emissions, you must demonstrate continuous compliance with the performance requirements... sudden, infrequent, and unavoidable failure of air pollution control equipment, process equipment, or a...

40 CFR 86.1825-01 - Durability demonstration procedures for refueling emissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Durability demonstration procedures for refueling emissions. 86.1825-01 Section 86.1825-01 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) General Compliance...

40 CFR 86.1825-08 - Durability demonstration procedures for refueling emissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Durability demonstration procedures for refueling emissions. 86.1825-08 Section 86.1825-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) General Compliance...

40 CFR 63.7903 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Containers § 63.7903 How do I demonstrate... each type of container used for your site remediation and subject to § 63.7886(b)(1)(ii). (2) For...

40 CFR 63.7946 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 14 2013-07-01 2013-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.7946 Section 63.7946 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants: Site Remediation...

40 CFR 63.7903 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Containers § 63.7903 How do I demonstrate... each type of container used for your site remediation and subject to § 63.7886(b)(1)(ii). (2) For...

40 CFR 63.7946 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 13 2011-07-01 2011-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.7946 Section 63.7946 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants: Site Remediation...

40 CFR 63.7903 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Containers § 63.7903 How do I demonstrate... each type of container used for your site remediation and subject to § 63.7886(b)(1)(ii). (2) For...

40 CFR 63.7946 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 14 2012-07-01 2011-07-01 true How do I monitor and collect data to demonstrate continuous compliance? 63.7946 Section 63.7946 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants: Site Remediation...

40 CFR 63.7903 - How do I demonstrate continuous compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Containers § 63.7903 How do I demonstrate... each type of container used for your site remediation and subject to § 63.7886(b)(1)(ii). (2) For...

40 CFR 63.7946 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 14 2014-07-01 2014-07-01 false How do I monitor and collect data to demonstrate continuous compliance? 63.7946 Section 63.7946 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants: Site Remediation...

Compliance and safety of a novel home exercise program for patients with high-grade brain tumors, a prospective observational study.

PubMed

Baima, Jennifer; Omer, Zehra B; Varlotto, John; Yunus, Shakeeb

2017-09-01

The purpose of this study is to evaluate compliance with and safety of a novel independent home exercise program for patients with high-grade brain tumors. We designed this program around the preferences and individual capabilities of this population as well as the potential barriers to exercise in cancer patients. Demographics were collected to better understand those that persisted with exercise. Subjects with high-grade brain tumor received one-time training that included watching an exercise video and live demonstration of resistance band exercises, a balance exercise, and recommendations for walking. Subjects were instructed to do the exercises every day for 1 month. Main outcome measures were percentage of subjects who exercised throughout the month, frequency of exercising, demographic factors, quality of life scores (assessed by FACT-BR), and self report of adverse events. Fourteen of the 15 (93%) subjects started the exercises during the course of the month. Nine of the fifteen (60%) continued the exercises throughout the month. Three additional subjects would have continued to exercise if formal or supervised rehabilitation had been offered. Among the subjects who continued the exercises regularly, higher frequency of exercising was significantly associated with living as married (p = 0.033), annual income >$50,000 (p = 0.047), scores of physical well-being (p = 0.047), and brain cancer specific well-being (p = 0.054) subscales. Among those who exercised frequently, there was also a trend towards increase in total FACT-BR scores (p = 0.059). The subjects who scored higher on the social well-being subscale of the FACT-BR at baseline self-reported a higher likelihood to continue the exercises after 1 month of participation in the study (p = 0.018). No adverse events were reported. Our small group of subjects with high-grade brain tumors demonstrated compliance with and safety of a novel independent strength and balance exercise program in the home setting. Higher frequency of exercising was associated with life quality parameters as well as marriage and income.

Equal Talents, Unequal Opportunities: A Report Card on State Support for Academically Talented Low-Income Students

ERIC Educational Resources Information Center

Plucker, Jonathan; Giancola, Jennifer; Healey, Grace; Arndt, Daniel; Wang, Chen

2015-01-01

Year after year, in every state and community in our nation, students from low-income families are less likely than other students to reach advanced levels of academic performance, even when demonstrating the potential to do so. These income-based "excellence gaps" appear in elementary school and continue through high school. It is a…

Comparison of GPS/SAC-C and MIPAS/ENVISAT temperature profiles and its implementation for EOS AURA-MLS observations

NASA Technical Reports Server (NTRS)

Jiang, Jonathan H.; Wang, Ding-Yi; Romans, Larry J.; Ao, Chi O.; Schwartz, Michael J.; Stiller, Gabriele P.; von Clarmann, Thomas; Lopez-Puertas, Manuel; Funke, Bernd; Gil-Lopez, Sergio;

Embracing the Big Picture: The State of New Jersey's Road toward a PK3 Continuum. ACNJ Policy Brief

ERIC Educational Resources Information Center

Rice, Cynthia

2007-01-01

There is evidence demonstrating that when young children are part of a learning environment that is based on high standards/expectations, administrative and teacher leadership and continuity in learning opportunities across these grades, the better their developmental outcomes will be through grade three and in future years. By experiencing an…

Oral Reading Fluency and Maze Measures as Predictors of Performance on North Carolina End-of-Grade Assessment of Reading Comprehension

ERIC Educational Resources Information Center

Galloway, Tara Watkins

2010-01-01

Current legislation (IDEA, 2004; NCLB, 2001) mandates all students, including students with disabilities, demonstrate progress toward the same standards. However, students continue to struggle with attainment of statewide academic standards as measured by high-stakes assessment. The purpose of the current study was to examine the degree that…

Observation of strong stimulated photorefractive scattering and self-pumped phase conjugation in LiNbO3:Mg in the ultraviolet

NASA Astrophysics Data System (ADS)

Qiao, Haijun; Tomita, Yasuo; Xu, Jingjun; Wu, Qiang; Zhang, Guoquan; Zhang, Guangyin

2005-09-01

We report on the observation of diffusion-dominant photorefraction and light-induced nonlinear forward and backward scattering in highly Mg-doped LiNbO3 at 351 nm. We also demonstrate what we believe to be the first continuous-wave self-pumped phase conjugation via stimulated photorefractive backscattering in the ultraviolet.

Low Threshold Voltage Continuous Wave Vertical-Cavity Surface-Emitting Lasers

DTIC Science & Technology

1993-04-26

Data are presented demonstrating a design and fabrication process for the realization of low- threshold , high-output vertical-cavity surface-emitting...layers), the low series resistance of the design results in a bias voltage on o 1.8 V at a threshold current of 1.9 mA for 10-micrometer-diam devices.... Vertical-cavity surface-emitting lasers.

Burst mode pumping: A new mechanism of drinking in mosquitoes

DOE PAGES

Kikuchi, Kenji; Stremler, Mark A.; Chatterjee, Souvick; ...

2018-03-20

Mosquitoes transport liquid foods into the body using two muscular pumps in the head. In normal drinking, these pumps reciprocate in a stereotyped pattern of oscillation, with a high frequency but small stroke volume. Do mosquitoes modulate their neuromotor programs for pumping to produce different drinking modes? More broadly, what are the mechanical consequences of a two-pump system in insects? To address these questions, we used synchrotron x-ray imaging and fluid mechanical modeling to investigate drinking performance in mosquitoes. X-ray imaging of the pumps during drinking revealed two modes of pumping: continuous reciprocation with multiple small strokes, and a newlymore » discovered ‘burst mode’ involving a single, large-volume stroke. Results from modeling demonstrate that burst mode pumping creates a very large pressure drop and high volume flow rate, but requires a massive increase in power, suggesting that continuous pumping is more economical for drinking. Modeling also demonstrates that, from one mode of pumping to the other, the mechanical role of the individual pumps changes. Furthermore, these results suggest that the advantage of a two-pump system in insects lies in its flexibility, enabling the animal to pump efficiently or powerfully as demanded by environmental considerations.« less

Electrical Tuning of Interlayer Exciton Gases in WSe2 Bilayers.

PubMed

Wang, Zefang; Chiu, Yi-Hsin; Honz, Kevin; Mak, Kin Fai; Shan, Jie

2018-01-10

van der Waals heterostructures formed by stacking two-dimensional atomic crystals are a unique platform for exploring new phenomena and functionalities. Interlayer excitons, bound states of spatially separated electron-hole pairs in van der Waals heterostructures, have demonstrated potential for rich valley physics and optoelectronics applications and been proposed to facilitate high-temperature superfluidity. Here, we demonstrate highly tunable interlayer excitons by an out-of-plane electric field in homobilayers of transition metal dichalcogenides. Continuous tuning of the exciton dipole from negative to positive orientation has been achieved, which is not possible in heterobilayers due to the presence of large built-in interfacial electric fields. A large linear field-induced redshift up to ∼100 meV has been observed in the exciton resonance energy. The Stark effect is accompanied by an enhancement of the exciton recombination lifetime by more than two orders of magnitude to >20 ns. The long recombination lifetime has allowed the creation of an interlayer exciton gas with density as large as 1.2 × 10 11 cm -2 by moderate continuous-wave optical pumping. Our results have paved the way for the realization of degenerate exciton gases in atomically thin semiconductors.

Burst mode pumping: A new mechanism of drinking in mosquitoes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kikuchi, Kenji; Stremler, Mark A.; Chatterjee, Souvick

Mosquitoes transport liquid foods into the body using two muscular pumps in the head. In normal drinking, these pumps reciprocate in a stereotyped pattern of oscillation, with a high frequency but small stroke volume. Do mosquitoes modulate their neuromotor programs for pumping to produce different drinking modes? More broadly, what are the mechanical consequences of a two-pump system in insects? To address these questions, we used synchrotron x-ray imaging and fluid mechanical modeling to investigate drinking performance in mosquitoes. X-ray imaging of the pumps during drinking revealed two modes of pumping: continuous reciprocation with multiple small strokes, and a newlymore » discovered ‘burst mode’ involving a single, large-volume stroke. Results from modeling demonstrate that burst mode pumping creates a very large pressure drop and high volume flow rate, but requires a massive increase in power, suggesting that continuous pumping is more economical for drinking. Modeling also demonstrates that, from one mode of pumping to the other, the mechanical role of the individual pumps changes. Furthermore, these results suggest that the advantage of a two-pump system in insects lies in its flexibility, enabling the animal to pump efficiently or powerfully as demanded by environmental considerations.« less

Self-assembly and continuous growth of hexagonal graphene flakes on liquid Cu

NASA Astrophysics Data System (ADS)

Cho, Seong-Yong; Kim, Min-Sik; Kim, Minsu; Kim, Ki-Ju; Kim, Hyun-Mi; Lee, Do-Joong; Lee, Sang-Hoon; Kim, Ki-Bum

2015-07-01

Graphene growth on liquid Cu has received great interest, owing to the self-assembly behavior of hexagonal graphene flakes with aligned orientation and to the possibility of forming a single grain of graphene through a commensurate growth of these graphene flakes. Here, we propose and demonstrate a two-step growth process which allows the formation of self-assembled, completely continuous graphene on liquid Cu. After the formation of full coverage on the liquid Cu, grain boundaries were revealed via selective hydrogen etching and the original grain boundaries were clearly resolved. This result indicates that, while the flakes self-assembled with the same orientation, there still remain structural defects, gaps and voids that were not resolved by optical microscopy or scanning electron microscopy. To overcome this limitation, the two-step growth process was employed, consisting of a sequential process of a normal single-layer graphene growth and self-assembly process with a low carbon flux, followed by the final stage of graphene growth at a high degree of supersaturation with a high carbon flux. Continuity of the flakes was verified via hydrogen etching and a NaCl-assisted oxidation process, as well as by measuring the electrical properties of the graphene grown by the two-step process. Two-step growth can provide a continuous graphene layer, but commensurate stitching should be further studied.Graphene growth on liquid Cu has received great interest, owing to the self-assembly behavior of hexagonal graphene flakes with aligned orientation and to the possibility of forming a single grain of graphene through a commensurate growth of these graphene flakes. Here, we propose and demonstrate a two-step growth process which allows the formation of self-assembled, completely continuous graphene on liquid Cu. After the formation of full coverage on the liquid Cu, grain boundaries were revealed via selective hydrogen etching and the original grain boundaries were clearly resolved. This result indicates that, while the flakes self-assembled with the same orientation, there still remain structural defects, gaps and voids that were not resolved by optical microscopy or scanning electron microscopy. To overcome this limitation, the two-step growth process was employed, consisting of a sequential process of a normal single-layer graphene growth and self-assembly process with a low carbon flux, followed by the final stage of graphene growth at a high degree of supersaturation with a high carbon flux. Continuity of the flakes was verified via hydrogen etching and a NaCl-assisted oxidation process, as well as by measuring the electrical properties of the graphene grown by the two-step process. Two-step growth can provide a continuous graphene layer, but commensurate stitching should be further studied. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr03352g

Measurement of complete and continuous Wigner functions for discrete atomic systems

NASA Astrophysics Data System (ADS)

Tian, Yali; Wang, Zhihui; Zhang, Pengfei; Li, Gang; Li, Jie; Zhang, Tiancai

2018-01-01

We measure complete and continuous Wigner functions of a two-level cesium atom in both a nearly pure state and highly mixed states. We apply the method [T. Tilma et al., Phys. Rev. Lett. 117, 180401 (2016), 10.1103/PhysRevLett.117.180401] of strictly constructing continuous Wigner functions for qubit or spin systems. We find that the Wigner function of all pure states of a qubit has negative regions and the negativity completely vanishes when the purity of an arbitrary mixed state is less than 2/3 . We experimentally demonstrate these findings using a single cesium atom confined in an optical dipole trap, which undergoes a nearly pure dephasing process. Our method can be applied straightforwardly to multi-atom systems for measuring the Wigner function of their collective spin state.

Continuous-Flow Detector for Rapid Pathogen Identification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barrett, Louise M.; Skulan, Andrew J.; Singh, Anup K.

2006-09-01

This report describes the continued development of a low-power, portable detector for the rapid identification of pathogens such as B. anthracis and smallpox. Based on our successful demonstration of the continuous filter/concentrator inlet, we believe strongly that the inlet section will enable differentiation between viable and non-viable populations, between types of cells, and between pathogens and background contamination. Selective, continuous focusing of particles in a microstream enables highly selective and sensitive identification using fluorescently labeled antibodies and other receptors such as peptides, aptamers, or small ligands to minimize false positives. Processes such as mixing and lysing will also benefit frommore » the highly localized particle streams. The concentrator is based on faceted prisms to contract microfluidic flows while maintaining uniform flowfields. The resulting interfaces, capable of high throughput, serve as high-, low-, and band-pass filters to direct selected bioparticles to a rapid, affinity-based detection system. The proposed device is superior to existing array-based detectors as antibody-pathogen binding can be accomplished in seconds rather than tens of minutes or even hours. The system is being designed to interface with aerosol collectors under development by the National Laboratories or commercial systems. The focused stream is designed to be interrogated using diode lasers to differentiate pathogens by light scattering. Identification of particles is done using fluorescently labeled antibodies to tag the particles, followed by multiplexed laser-induced fluorescence (LIF) detection (achieved by labeling each antibody with a different dye).« less

On the accuracy and reproducibility of a novel probabilistic atlas-based generation for calculation of head attenuation maps on integrated PET/MR scanners.

PubMed

Chen, Kevin T; Izquierdo-Garcia, David; Poynton, Clare B; Chonde, Daniel B; Catana, Ciprian

2017-03-01

To propose an MR-based method for generating continuous-valued head attenuation maps and to assess its accuracy and reproducibility. Demonstrating that novel MR-based photon attenuation correction methods are both accurate and reproducible is essential prior to using them routinely in research and clinical studies on integrated PET/MR scanners. Continuous-valued linear attenuation coefficient maps ("μ-maps") were generated by combining atlases that provided the prior probability of voxel positions belonging to a certain tissue class (air, soft tissue, or bone) and an MR intensity-based likelihood classifier to produce posterior probability maps of tissue classes. These probabilities were used as weights to generate the μ-maps. The accuracy of this probabilistic atlas-based continuous-valued μ-map ("PAC-map") generation method was assessed by calculating the voxel-wise absolute relative change (RC) between the MR-based and scaled CT-based attenuation-corrected PET images. To assess reproducibility, we performed pair-wise comparisons of the RC values obtained from the PET images reconstructed using the μ-maps generated from the data acquired at three time points. The proposed method produced continuous-valued μ-maps that qualitatively reflected the variable anatomy in patients with brain tumor and agreed well with the scaled CT-based μ-maps. The absolute RC comparing the resulting PET volumes was 1.76 ± 2.33 %, quantitatively demonstrating that the method is accurate. Additionally, we also showed that the method is highly reproducible, the mean RC value for the PET images reconstructed using the μ-maps obtained at the three visits being 0.65 ± 0.95 %. Accurate and highly reproducible continuous-valued head μ-maps can be generated from MR data using a probabilistic atlas-based approach.

Spontaneous gene transfection of human bone cells using 3D mineralized alginate-chitosan macrocapsules.

PubMed

Green, David W; Kim, Eun-Jung; Jung, Han-Sung

2015-09-01

The effectiveness of nonviral gene therapy remains uncertain because of low transfection efficiencies and high toxicities compared with viral-based strategies. We describe a simple system for transient transfection of continuous human cell lines, with low toxicity, using mineral-coated chitosan and alginate capsules. As proof-of-concept, we demonstrate transfection of Saos-2 and MG63 human osteosarcoma continuous cell lines with gfp, LacZ reporter genes, and a Sox-9 carrying plasmid, to illustrate expression of a functional gene with therapeutic relevance. We show that continuous cell lines transfect with significant efficiency of up to 65% possibly through the interplay between chitosan and DNA complexation and calcium/phosphate-induced translocation into cells entrapped within the 3D polysaccharide based environment, as evidenced by an absence of transfection in unmineralized and chitosan-free capsules. We demonstrated that our transfection system was equally effective at transfection of primary human bone marrow stromal cells. To illustrate, the Sox-9, DNA plasmid was spontaneously expressed in primary human bone marrow stromal cells at 7 days with up to 90% efficiency in two repeats. Mineralized polysaccharide macrocapsules are gene delivery vehicles with a number of biological and practical advantages. They are highly efficient at self-transfecting primary bone cells, with programmable spatial and temporal delivery prospects, premineralized bone-like environments, and have no cytotoxic effects, as compared with many other nonviral systems. © 2015 Wiley Periodicals, Inc.

Conical-scan tracking with the 64-m-diameter antenna at goldstone

NASA Technical Reports Server (NTRS)

Ohlson, J. E.; Reid, M. S.

1976-01-01

The theory and experimental work which demonstrated the feasibility of conical-scan tracking with a 64 m diameter paraboloid antenna is documented. The purpose of this scheme is to actively track spacecraft and radio sources continuously with an accuracy superior to that obtained by manual correction of the computer driven pointing. The conical-scan implementation gives increased tracking accuracy with X-band spacecraft signals, as demonstrated in the Mariner Venus/Mercury 1973 mission. Also, the high accuracy and ease of measurement with conical-scan tracking allow evaluation of systematic and random antenna tracking errors.

Ultra-low power generation of twin photons in a compact silicon ring resonator.

PubMed

Azzini, Stefano; Grassani, Davide; Strain, Michael J; Sorel, Marc; Helt, L G; Sipe, J E; Liscidini, Marco; Galli, Matteo; Bajoni, Daniele

2012-10-08

We demonstrate efficient generation of correlated photon pairs by spontaneous four wave mixing in a 5 μm radius silicon ring resonator in the telecom band around 1550 nm. By optically pumping our device with a 200 μW continuous wave laser, we obtain a pair generation rate of 0.2 MHz and demonstrate photon time correlations with a coincidence-to-accidental ratio as high as 250. The results are in good agreement with theoretical predictions and show the potential of silicon micro-ring resonators as room temperature sources for integrated quantum optics applications.

The physics of transverse mode instability-induced nonlinear phase distortions in large area optical fiber amplifiers and their mitigation with applications in scaling of pulsed and continuous wave high-energy lasers

DTIC Science & Technology

2016-12-13

plate and novel all-fiber fused coupler. Such work has laid the platform to demonstrate the mitigation of thermal mode instability through vortex beam...at IIT Madras to experimentally validate the above results as well as to explore the generation of vortex modes through a spiral phase plate and...modes through spiral phase plates and novel all-fiber fused couplers. We have demonstrated the excitation of a vortex mode with charge 1 through a

High temperature polymer dielectric film-wire insulation

NASA Technical Reports Server (NTRS)

Nairus, John G.

1994-01-01

The highlights of the program are outlined including two major accomplishments. TRW identified and demonstrated the potential of two aromatic/heterocyclic polymers to have an outstanding and superior combination of electrical, thermal, and chemical resistance properties versus state-of-the-art Kapton for spacecraft and/or aircraft dielectric insulation applications. (Supporting data is provided in tables.) Feasibility was demonstrated for supporting/enabling technologies such as ceramic coatings, continuous film casting, and conductor wire wrapping, which are designed to accelerate qualification and deployment of the new wire insulation materials for USAF systems applications during the mid- to late-1990's.

Computer-based learning in neuroanatomy: A longitudinal study of learning, transfer, and retention

NASA Astrophysics Data System (ADS)

Chariker, Julia H.

A longitudinal experiment was conducted to explore computer-based learning of neuroanatomy. Using a realistic 3D graphical model of neuroanatomy, and sections derived from the model, exploratory graphical tools were integrated into interactive computer programs so as to allow adaptive exploration. 72 participants learned either sectional anatomy alone or learned whole anatomy followed by sectional anatomy. Sectional anatomy was explored either in perceptually continuous animation or discretely, as in the use of an anatomical atlas. Learning was measured longitudinally to a high performance criterion. After learning, transfer to biomedical images and long-term retention was tested. Learning whole anatomy prior to learning sectional anatomy led to a more efficient learning experience. Learners demonstrated high levels of transfer from whole anatomy to sectional anatomy and from sectional anatomy to complex biomedical images. All learning groups demonstrated high levels of retention at 2--3 weeks.

Heat-sink free CW operation of injection microdisk lasers grown on Si substrate with emission wavelength beyond 1.3  μm.

PubMed

Kryzhanovskaya, Natalia; Moiseev, Eduard; Polubavkina, Yulia; Maximov, Mikhail; Kulagina, Marina; Troshkov, Sergey; Zadiranov, Yury; Guseva, Yulia; Lipovskii, Andrey; Tang, Mingchu; Liao, Mengya; Wu, Jiang; Chen, Siming; Liu, Huiyun; Zhukov, Alexey

2017-09-01

High-performance injection microdisk (MD) lasers grown on Si substrate are demonstrated for the first time, to the best of our knowledge. Continuous-wave (CW) lasing in microlasers with diameters from 14 to 30 μm is achieved at room temperature. The minimal threshold current density of 600  A/cm 2 (room temperature, CW regime, heatsink-free uncooled operation) is comparable to that of high-quality MD lasers on GaAs substrates. Microlasers on silicon emit in the wavelength range of 1320-1350 nm via the ground state transition of InAs/InGaAs/GaAs quantum dots. The high stability of the lasing wavelength (dλ/dI=0.1  nm/mA) and the low specific thermal resistance of 4×10 -3 °C×cm 2 /W are demonstrated.

Integrated continuous processing of proteins expressed as inclusion bodies: GCSF as a case study.

PubMed

Kateja, Nikhil; Agarwal, Harshit; Hebbi, Vishwanath; Rathore, Anurag S

2017-07-01

Affordability of biopharmaceuticals continues to be a challenge, particularly in developing economies. This has fuelled advancements in manufacturing that can offer higher productivity and better economics without sacrificing product quality in the form of an integrated continuous manufacturing platform. While platform processes for monoclonal antibodies have existed for more than a decade, development of an integrated continuous manufacturing process for bacterial proteins has received relatively scant attention. In this study, we propose an end-to-end integrated continuous downstream process (from inclusion bodies to unformulated drug substance) for a therapeutic protein expressed in Escherichia coli as inclusion body. The final process consisted of a continuous refolding in a coiled flow inverter reactor directly coupled to a three-column periodic counter-current chromatography for capture of the product followed by a three-column con-current chromatography for polishing. The continuous bioprocessing train was run uninterrupted for 26 h to demonstrate its capability and the resulting output was analyzed for the various critical quality attributes, namely product purity (>99%), high molecular weight impurities (<0.5%), host cell proteins (<100 ppm), and host cell DNA (<10 ppb). All attributes were found to be consistent over the period of operation. The developed assembly offers smaller facility footprint, higher productivity, fewer hold steps, and significantly higher equipment and resin utilization. The complexities of process integration in the context of continuous processing have been highlighted. We hope that the study presented here will promote development of highly efficient, universal, end-to-end, fully continuous platforms for manufacturing of biotherapeutics. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 33:998-1009, 2017. © 2016 American Institute of Chemical Engineers.

40 CFR 63.5895 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true How do I monitor and collect data to... Composites Production Continuous Compliance Requirements § 63.5895 How do I monitor and collect data to demonstrate continuous compliance? (a) During production, you must collect and keep a record of data as...

40 CFR 63.5895 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I monitor and collect data to... Composites Production Continuous Compliance Requirements § 63.5895 How do I monitor and collect data to demonstrate continuous compliance? (a) During production, you must collect and keep a record of data as...

40 CFR 60.3033 - How do I demonstrate continuous compliance with the emission limitations and the operating limits?

Code of Federal Regulations, 2011 CFR

2011-07-01

... in § 60.3027. (b) You must continuously monitor carbon monoxide emissions to determine compliance... compliance with the emission limitations and the operating limits? 60.3033 Section 60.3033 Protection of... Requirements § 60.3033 How do I demonstrate continuous compliance with the emission limitations and the...

40 CFR 60.3033 - How do I demonstrate continuous compliance with the emission limitations and the operating limits?

Code of Federal Regulations, 2013 CFR

2013-07-01

... in § 60.3027. (b) You must continuously monitor carbon monoxide emissions to determine compliance... compliance with the emission limitations and the operating limits? 60.3033 Section 60.3033 Protection of... Requirements § 60.3033 How do I demonstrate continuous compliance with the emission limitations and the...

40 CFR 60.3033 - How do I demonstrate continuous compliance with the emission limitations and the operating limits?

Code of Federal Regulations, 2010 CFR

2010-07-01

... in § 60.3027. (b) You must continuously monitor carbon monoxide emissions to determine compliance... compliance with the emission limitations and the operating limits? 60.3033 Section 60.3033 Protection of... Requirements § 60.3033 How do I demonstrate continuous compliance with the emission limitations and the...

40 CFR 60.3033 - How do I demonstrate continuous compliance with the emission limitations and the operating limits?

Code of Federal Regulations, 2014 CFR

2014-07-01

... in § 60.3027. (b) You must continuously monitor carbon monoxide emissions to determine compliance... compliance with the emission limitations and the operating limits? 60.3033 Section 60.3033 Protection of... Requirements § 60.3033 How do I demonstrate continuous compliance with the emission limitations and the...

40 CFR 60.3033 - How do I demonstrate continuous compliance with the emission limitations and the operating limits?

Code of Federal Regulations, 2012 CFR

2012-07-01

... in § 60.3027. (b) You must continuously monitor carbon monoxide emissions to determine compliance... compliance with the emission limitations and the operating limits? 60.3033 Section 60.3033 Protection of... Requirements § 60.3033 How do I demonstrate continuous compliance with the emission limitations and the...

Evidence-based outcomes of holmium laser enucleation of the prostate.

PubMed

Large, Tim; Krambeck, Amy E

2018-05-01

Holmium laser enucleation of the prostate (HoLEP) has been a mainstay therapy for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostate hyperplasia (BPH) for nearly 20 years. We briefly review current and sentinel publications that provide outcomes data after HoLEP. Current literature continues to support HoLEP as a versatile and durable surgical option for men with LUTS secondary to BPH. Despite evidence supporting durable symptom relief beyond 10 years even in large prostate glands, HoLEP is still not widely available to all patients. Concerns surrounding the learning curve of the procedure, high rates of retrograde ejaculation, and transient urinary incontinence seem to persist and limit the adoption of HoLEP by established urologists and residency training programs. Recent publications continue to show excellent short-term and long-term outcomes after HoLEP, in the categories of voiding function and patient satisfaction. Continued attempts to demonstrate equivalent outcomes of alternate-BPH surgical techniques are being met with renewed efforts by those performing HoLEP to demonstrate equivalent outcomes and patient safety during the learning phase of HoLEP for both mentored and self-directed surgical training.

Continuous-wave room-temperature diamond maser

NASA Astrophysics Data System (ADS)

Breeze, Jonathan D.; Salvadori, Enrico; Sathian, Juna; Alford, Neil Mcn.; Kay, Christopher W. M.

2018-03-01

The maser—the microwave progenitor of the optical laser—has been confined to relative obscurity owing to its reliance on cryogenic refrigeration and high-vacuum systems. Despite this, it has found application in deep-space communications and radio astronomy owing to its unparalleled performance as a low-noise amplifier and oscillator. The recent demonstration of a room-temperature solid-state maser that utilizes polarized electron populations within the triplet states of photo-excited pentacene molecules in a p-terphenyl host paves the way for a new class of maser. However, p-terphenyl has poor thermal and mechanical properties, and the decay rates of the triplet sublevel of pentacene mean that only pulsed maser operation has been observed in this system. Alternative materials are therefore required to achieve continuous emission: inorganic materials that contain spin defects, such as diamond and silicon carbide, have been proposed. Here we report a continuous-wave room-temperature maser oscillator using optically pumped nitrogen–vacancy defect centres in diamond. This demonstration highlights the potential of room-temperature solid-state masers for use in a new generation of microwave devices that could find application in medicine, security, sensing and quantum technologies.

Continuous-wave room-temperature diamond maser.

PubMed

Breeze, Jonathan D; Salvadori, Enrico; Sathian, Juna; Alford, Neil McN; Kay, Christopher W M

2018-03-21

The maser-the microwave progenitor of the optical laser-has been confined to relative obscurity owing to its reliance on cryogenic refrigeration and high-vacuum systems. Despite this, it has found application in deep-space communications and radio astronomy owing to its unparalleled performance as a low-noise amplifier and oscillator. The recent demonstration of a room-temperature solid-state maser that utilizes polarized electron populations within the triplet states of photo-excited pentacene molecules in a p-terphenyl host paves the way for a new class of maser. However, p-terphenyl has poor thermal and mechanical properties, and the decay rates of the triplet sublevel of pentacene mean that only pulsed maser operation has been observed in this system. Alternative materials are therefore required to achieve continuous emission: inorganic materials that contain spin defects, such as diamond and silicon carbide, have been proposed. Here we report a continuous-wave room-temperature maser oscillator using optically pumped nitrogen-vacancy defect centres in diamond. This demonstration highlights the potential of room-temperature solid-state masers for use in a new generation of microwave devices that could find application in medicine, security, sensing and quantum technologies.

Long-term reproducibility of relative sensitivity factors obtained with CAMECA Wf

NASA Astrophysics Data System (ADS)

Gui, D.; Xing, Z. X.; Huang, Y. H.; Mo, Z. Q.; Hua, Y. N.; Zhao, S. P.; Cha, L. Z.

2008-12-01

As the wafer size continues to increase and the feature size of the integrated circuits (IC) continues to shrink, process control of IC manufacturing becomes ever more important to reduce the cost of failures caused by the drift of processes or equipments. Characterization tools with high precision and reproducibility are required to capture any abnormality of the process. Although Secondary ion mass spectrometry (SIMS) has been widely used in dopant profile control, it was reported that magnetic sector SIMS, compared to quadrupole SIMS, has lower short-term repeatability and long-term reproducibility due to the high extraction field applied between sample and extraction lens. In this paper, we demonstrate that CAMECA Wf can deliver high long-term reproducibility because of its high-level automation and improved design of immersion lens. The relative standard deviation (R.S.D.) of the relative sensitivity factors (RSF) of three typical elements, i.e., boron (B), phosphorous (P) and nitrogen (N), over 3 years are 3.7%, 5.5% and 4.1%, respectively. The high reproducibility results have a practical implication that deviation can be estimated without testing the standards.

A continuous high-throughput bioparticle sorter based on 3D traveling-wave dielectrophoresis.

PubMed

Cheng, I-Fang; Froude, Victoria E; Zhu, Yingxi; Chang, Hsueh-Chia; Chang, Hsien-Chang

2009-11-21

We present a high throughput (maximum flow rate approximately 10 microl/min or linear velocity approximately 3 mm/s) continuous bio-particle sorter based on 3D traveling-wave dielectrophoresis (twDEP) at an optimum AC frequency of 500 kHz. The high throughput sorting is achieved with a sustained twDEP particle force normal to the continuous through-flow, which is applied over the entire chip by a single 3D electrode array. The design allows continuous fractionation of micron-sized particles into different downstream sub-channels based on differences in their twDEP mobility on both sides of the cross-over. Conventional DEP is integrated upstream to focus the particles into a single levitated queue to allow twDEP sorting by mobility difference and to minimize sedimentation and field-induced lysis. The 3D electrode array design minimizes the offsetting effect of nDEP (negative DEP with particle force towards regions with weak fields) on twDEP such that both forces increase monotonically with voltage to further increase the throughput. Effective focusing and separation of red blood cells from debris-filled heterogeneous samples are demonstrated, as well as size-based separation of poly-dispersed liposome suspensions into two distinct bands at 2.3 to 4.6 microm and 1.5 to 2.7 microm, at the highest throughput recorded in hand-held chips of 6 microl/min.

Dynamic Torsional and Cyclic Fracture Behavior of ProFile Rotary Instruments at Continuous or Reciprocating Rotation as Visualized with High-speed Digital Video Imaging.

PubMed

Tokita, Daisuke; Ebihara, Arata; Miyara, Kana; Okiji, Takashi

2017-08-01

This study examined the dynamic fracture behavior of nickel-titanium rotary instruments in torsional or cyclic loading at continuous or reciprocating rotation by means of high-speed digital video imaging. The ProFile instruments (size 30, 0.06 taper; Dentsply Maillefer, Ballaigues, Switzerland) were categorized into 4 groups (n = 7 in each group) as follows: torsional/continuous (TC), torsional/reciprocating (TR), cyclic/continuous (CC), and cyclic/reciprocating (CR). Torsional loading was performed by rotating the instruments by holding the tip with a vise. For cyclic loading, a custom-made device with a 38° curvature was used. Dynamic fracture behavior was observed with a high-speed camera. The time to fracture was recorded, and the fractured surface was examined with scanning electron microscopy. The TC group initially exhibited necking of the file followed by the development of an initial crack line. The TR group demonstrated opening and closing of a crack according to its rotation in the cutting and noncutting directions, respectively. The CC group separated without any detectable signs of deformation. In the CR group, initial crack formation was recognized in 5 of 7 samples. The reciprocating rotation exhibited a longer time to fracture in both torsional and cyclic fatigue testing (P < .05). The scanning electron microscopic images showed a severely deformed surface in the TR group. The dynamic fracture behavior of NiTi rotary instruments, as visualized with high-speed digital video imaging, varied between the different modes of rotation and different fatigue testing. Reciprocating rotation induced a slower crack propagation and conferred higher fatigue resistance than continuous rotation in both torsional and cyclic loads. Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

A pilot study examining the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular risk factors in cancer survivors.

PubMed

Toohey, Kellie; Pumpa, Kate L; Arnolda, Leonard; Cooke, Julie; Yip, Desmond; Craft, Paul S; Semple, Stuart

2016-01-01

The aim of this study was to evaluate the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular disease risk factors in cancer survivors. Cancer survivors within 24 months post-diagnosis were randomly assigned into the low-volume high-intensity interval training group ( n  = 8) or the continuous low to moderate intensity training group ( n  = 8) group for 36 sessions (12 weeks) of supervised exercise. The low-volume high-intensity interval training (LVHIIT) group performed 7 × 30 s intervals (≥85% maximal heart rate) and the continuous low to moderate intensity training (CLMIT) group performed continuous aerobic training for 20 min (≤55% maximal heart rate) on a stationary bike or treadmill. Significant improvements (time) were observed for 13 of the 23 dependent variables (ES 0.05-0.61, p  ≤ 0.05). An interaction effect was observed for six minute walk test (18.53% [32.43-4.63] ES 0.50, p  ≤ 0.01) with the LVHIIT group demonstrating greater improvements. These preliminary findings suggest that both interventions can induce improvements in quality of life, functional capacity and selected cardiovascular disease risk factors. The LVHIIT program was well tolerated by the participants and our results suggest that LVHIIT is the preferred modality to improve fitness (6MWT); it remains to be seen which intervention elicits the most clinically relevant outcomes for patients. A larger sample size with a control group is required to confirm the significance of these findings.

A pilot study examining the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular risk factors in cancer survivors

PubMed Central

Pumpa, Kate L.; Arnolda, Leonard; Cooke, Julie; Yip, Desmond; Craft, Paul S.; Semple, Stuart

2016-01-01

Purpose The aim of this study was to evaluate the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular disease risk factors in cancer survivors. Methods Cancer survivors within 24 months post-diagnosis were randomly assigned into the low-volume high-intensity interval training group (n = 8) or the continuous low to moderate intensity training group (n = 8) group for 36 sessions (12 weeks) of supervised exercise. The low-volume high-intensity interval training (LVHIIT) group performed 7 × 30 s intervals (≥85% maximal heart rate) and the continuous low to moderate intensity training (CLMIT) group performed continuous aerobic training for 20 min (≤55% maximal heart rate) on a stationary bike or treadmill. Results Significant improvements (time) were observed for 13 of the 23 dependent variables (ES 0.05–0.61, p ≤ 0.05). An interaction effect was observed for six minute walk test (18.53% [32.43–4.63] ES 0.50, p ≤ 0.01) with the LVHIIT group demonstrating greater improvements. Conclusion These preliminary findings suggest that both interventions can induce improvements in quality of life, functional capacity and selected cardiovascular disease risk factors. The LVHIIT program was well tolerated by the participants and our results suggest that LVHIIT is the preferred modality to improve fitness (6MWT); it remains to be seen which intervention elicits the most clinically relevant outcomes for patients. A larger sample size with a control group is required to confirm the significance of these findings. PMID:27781180

Study, optimization, and design of a laser heat engine

NASA Technical Reports Server (NTRS)

1978-01-01

Laser heat engine concepts, proposed for satellite applications, were analyzed to determine which engine concepts best meet the requirements of high efficiency (50 percent or better) continuous operation in space. The best laser heat engine for a near-term experimental demonstration, selected on the basis of high overall operating efficiency, high power-to-weight characteristics, and availability of the required technology, is an Otto/Diesel cycle piston engine using a diamond window to admit CO2 laser radiation. The technology with the greatest promise of scaling to megawatt power levels in the long term is the energy exchanger/gas turbine combination.

Spectrum-agile hundred-watt-level high-power random fiber laser enabled by watt-level tunable optical filter

NASA Astrophysics Data System (ADS)

Ye, Jun; Xu, Jiangming; Song, Jiaxin; Wu, Hanshuo; Zhang, Hanwei; Wu, Jian; Zhou, Pu

2018-06-01

Through high-fidelity numerical modeling and careful system-parameter design, we demonstrate the spectral manipulation of a hundred-watt-level high-power random fiber laser (RFL) by employing a watt-level tunable optical filter. Consequently, a >100-W RFL with the spectrum-agile property is achieved. The central wavelength can be continuously tuned with a range of ∼20 nm, and the tuning range of the full width at half maximum linewidth, which is closely related to the central wavelength, covers ∼1.1 to ∼2.7 times of the minimum linewidth.

Ultra high resolution molecular beam cars spectroscopy with application to planetary atmospheric molecules

NASA Technical Reports Server (NTRS)

Byer, R. L.

1982-01-01

The measurement of high resolution pulsed and continuous wave (CW) coherent anti-Stokes Raman spectroscopy (CARS) measurements in pulsed and steady state supersonic expansions were demonstrated. Pulsed molecular beam sources were characterized, and saturation of a Raman transition and, for the first time, the Raman spectrum of a complex molecular cluster were observed. The observation of CW CARS spectra in a molecular expansion and the effects of transit time broadening is described. Supersonic expansion is established as a viable technique for high resolution Raman spectroscopy of cold molecules with resolutions of 100 MH2.

Efficient neutron generation from solid-nanoparticle explosions driven by DPSSL-pumped high-repetition rate femtosecond laser pulse

NASA Astrophysics Data System (ADS)

Watari, T.; Matsukado, K.; Sekine, T.; Takeuchi, Y.; Hatano, Y.; Yoshimura, R.; Satoh, N.; Nishihara, K.; Takagi, M.; Kawashima, T.

2016-03-01

We propose novel neutron source using high-intensity laser based on the cluster fusion scheme. We developed DPSSL-pumped high-repetition-rate 20-TW laser system and solid nanoparticle target for neutron generation demonstration. In our neutron generation experiment, high-energy deuterons were generated from coulomb explosion of CD solid- nanoparticles and neutrons were generated by DD fusion reaction. Efficient and stable neutron generation was obtained by irradiating an intense femtosecond laser pulse of >2×1018 W/cm2. A yield of ∼105 neutrons per shot was stably observed during 0.1-1 Hz continuous operation.

A compact, high temperature nuclear magnetic resonance probe for use in a narrow-bore superconducting magnet

NASA Astrophysics Data System (ADS)

Adler, Stuart B.; Michaels, James N.; Reimer, Jeffrey A.

1990-11-01

The design of a nuclear magnetic resonance (NMR) probe is reported, that can be used in narrow-bore superconducting solenoids for the observation of nuclear induction at high temperatures. The probe is compact, highly sensitive, and stable in continuous operation at temperatures up to 1050 C. The essential feature of the probe is a water-cooled NMR coil that contains the sample-furnace; this design maximizes sensitivity and circuit stability by maintaining the probe electronics at ambient temperature. The design is demonstrated by showing high temperature O-17 NMR spectra and relaxation measurements in solid barium bismuth oxide and yttria-stabilized zirconia.

Ground penetrating radar coal measurements demonstration at the U.S. Bureau of Mines Research Center, Pittsburgh, Pennsylvania. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gardner, D.; Guerrier, J.; Martinez, M.

1994-01-04

In situ and near real-time measurements of coal seam thickness have been identified by industry as a highly desirable component of robotic mining systems. With it, a continuous mining machine can be guided close to the varying boundary of the seam while the cutting operation is underway. This provides the mining operation the ability to leave behind the high-sulfur, high-particulate coal which is concentrated near the seam boundary. The result is near total recovery of high quality coal resources, an increase in mining efficiency, and opportunities for improved safety through reduction in personnel in the most hazardous coal cutting areas.more » In situ, real-time coal seam measurements using the Special Technologies Laboratory (STL) ground penetrating radar (GPR) technology were shown feasible by a demonstration in a Utah coal mine on April 21, 1994. This report describes the October 18, 1994 in situ GPR measurements of coal seam thickness at the US Bureau of Mines (USBM) robotic mining testing laboratory. In this report, an overview of the measurements at the USBM Laboratory is given. It is followed by a description of the technical aspects of the STL frequency modulated-continuous wave (FM-CW) GPR system. Section 4 provides a detailed description of the USBM Laboratory measurements and the conditions under which they were taken. Section 5 offers conclusions and possibilities for future communications.« less

Investigation on filter method for smoothing spiral phase plate

NASA Astrophysics Data System (ADS)

Zhang, Yuanhang; Wen, Shenglin; Luo, Zijian; Tang, Caixue; Yan, Hao; Yang, Chunlin; Liu, Mincai; Zhang, Qinghua; Wang, Jian

2018-03-01

Spiral phase plate (SPP) for generating vortex hollow beams has high efficiency in various applications. However, it is difficult to obtain an ideal spiral phase plate because of its continuous-varying helical phase and discontinued phase step. This paper describes the demonstration of continuous spiral phase plate using filter methods. The numerical simulations indicate that different filter method including spatial domain filter, frequency domain filter has unique impact on surface topography of SPP and optical vortex characteristics. The experimental results reveal that the spatial Gaussian filter method for smoothing SPP is suitable for Computer Controlled Optical Surfacing (CCOS) technique and obtains good optical properties.

A novel continuous fractional sliding mode control

NASA Astrophysics Data System (ADS)

Muñoz-Vázquez, A. J.; Parra-Vega, V.; Sánchez-Orta, A.

2017-10-01

A new fractional-order controller is proposed, whose novelty is twofold: (i) it withstands a class of continuous but not necessarily differentiable disturbances as well as uncertainties and unmodelled dynamics, and (ii) based on a principle of dynamic memory resetting of the differintegral operator, it is enforced an invariant sliding mode in finite time. Both (i) and (ii) account for exponential convergence of tracking errors, where such principle is instrumental to demonstrate the closed-loop stability, robustness and a sustained sliding motion, as well as that high frequencies are filtered out from the control signal. The proposed methodology is illustrated with a representative simulation study.

High-power continuous-wave tunable 544- and 272-nm beams based on a diode-oscillator fiber-amplifier for calcium spectroscopy

NASA Astrophysics Data System (ADS)

Ko, Kwang-Hoon; Kim, Yonghee; Park, Hyunmin; Cha, Yong-Ho; Kim, Taek-Soo; Lee, Lim; Lim, Gwon; Han, Jaemin; Ko, Kwang-Hee; Jeong, Do-Young

2015-08-01

Continuous-wave single-frequency tunable 544- and 272-nm beams have been demonstrated by the second- and fourth-harmonic conversions of a 1088-nm fundamental beam from a diode-oscillator fiber-amplifier. The single-pass second-harmonic generation with a MgO-doped periodically poled stoichiometric LiTaO3 crystal and the external-cavity frequency-doubling technique with a bulk BBO crystal were employed to achieve an approximately 6-W 544-nm beam and a 1.5-W 272-nm beam, respectively. We characterized the second- and fourth-harmonic generations and discussed their applications to calcium spectroscopy.

Continuous recrystallization during thermomechanical processing of a superplastic Al-10Mg-0.1Zr alloy

NASA Technical Reports Server (NTRS)

Hales, S. J.; Mcnelley, T. R.; Crooks, R.

1990-01-01

Microstructural evolution via static continuous recrystallization during thermomechanical processing of an Al-Mg-Zr alloy is addressed. Mechanical property data demonstrated that as-rolled material was capable of superplastic response without further treatment. Further, superplastic ductility at 300 C was enhanced by a factor of five by increasing the reheating time between rolling passes during processing also at 300 C. This enhanced ductility was associated with a Cu-texture and a microstructure consisting of predominantly high-angle boundaries. Processing to minimize recovery resulted in a strong Brass-texture component, a predominantly low-angle boundary microstructure and poorer ductility.

Air Force seal activities

NASA Astrophysics Data System (ADS)

Mayhew, Ellen R.

1994-07-01

Seal technology development is an important part of the Air Force's participation in the Integrated High Performance Turbine Engine Technology (IHPTET) initiative, the joint DOD, NASA, ARPA, and industry endeavor to double turbine engine capabilities by the turn of the century. Significant performance and efficiency improvements can be obtained through reducing internal flow system leakage, but seal environment requirements continue to become more extreme as the engine thermodynamic cycles advance towards these IHPTET goals. Brush seal technology continues to be pursued by the Air Force to reduce leakage at the required conditions. Likewise, challenges in engine mainshaft air/oil seals are also being addressed. Counter-rotating intershaft applications within the IHPTET initiative involve very high rubbing velocities. This viewgraph presentation briefly describes past and current seal research and development programs and gives a summary of seal applications in demonstrator and developmental engine testing.

AEA Cell-Bypass-Switch Activation: An Update

NASA Technical Reports Server (NTRS)

Keys, Denney; Rao, Gopalakrishna M.; Wannemacher, Harry

2002-01-01

The objectives of this project included the following: (1) verify the performance of AEA cell bypass protection device (CBPD) under simulated EOS-Aqua/Aura flight hardware configuration; (2) assess the safety of the hardware under an inadvertent firing of CBPD switch, as well as the closing of CBPD; and (3) confirm that the mode of operation of CBPD switch is the formation of a continuous low impedance path (a homogeneous low melting point alloy). The nominal performance of AEA CBPD under flight operating conditions (vacuum except zero-G, and high impedance cell) has been demonstrated. There is no evidence of cell rupture or excessive heat production during or after CBPD switch activation under simulated high cell impedance (open-circuit cell failure mode). The formation of a continuous low impedance path (a homogeneous low melting point alloy) has been confirmed.

250W continuous-tunable all-fiberized single-frequency polarization-maintained amplifiers with wavelength spanning from 1065 nm to 1090 nm

NASA Astrophysics Data System (ADS)

Liu, Yakun; Su, Rongtao; Wang, Xiaolin; Ma, Pengfei; Zhang, Hanwei; Si, Lei

2017-10-01

In this manuscript, we demonstrate an all-fiberized, single-frequency and polarization-maintained (PM) amplifiers with wavelength tuned from 1065 nm to 1090 nm. The ASE is suppressed by a signal to noise ratio of higher than 27 dB, and each wavelengths can be amplified to be 250 W output power. The stimulated Brillouin scattering (SBS) effect in such high power amplifiers is suppressed by employing a high dopant fiber (10 dB/m). The polarization extinction ratio (PER) of the amplifier is over 20 dB at the maximum output power. It should be noted that although the experiments are conducted at the wavelength from 1065 nm to 1090 nm with a step of 5 nm, the wavelength can also be continuously tuned.

A fiber air-gap Fabry-Pérot temperature sensor demodulated by using frequency modulated continuous wave

NASA Astrophysics Data System (ADS)

Zheng, Wanfu; Xie, Jianglei; Li, Yi; Xu, Ben; Kang, Juan; Shen, Changyu; Wang, Jianfeng; Jin, Yongxing; Liu, Honglin; Ni, Kai; Dong, Xinyong; Zhao, Chunliu; Jin, Shangzhong

In this study, a fiber in-line air-gap Fabry-Pérot interferometer (FPI) is fabricated by HF acid etching. For a low-cost and higher precise measurement, a demodulation system based on frequency modulated continuous wave (FMCW) technique is build up and demonstrated in this air-gap FPI. In temperature measurements, the temperature sensitivity is about 1.75 rad/°C by phase shift detection. We also test the long term performance of the system and the RMS error is about 0.04 rad, which corresponds to the temperature resolution of ~0.02 °C. It is much higher than the measurement resolution by using the traditional wavelength shift detection method. Our experiments show that the FMCW can provide a low-cost, high resolution and high speed interrogation solution to the fiber FPIs.

Extended and quasi-continuous tuning of quantum cascade lasers using superstructure gratings and integrated heaters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bidaux, Yves, E-mail: yves.bidaux@alpeslasers.ch; Institute for Quantum Electronics, ETH-Zurich, CH-8093 Zurich; Bismuto, Alfredo, E-mail: alfredo.bismuto@alpeslasers.ch

2015-11-30

In this work, we demonstrate broad electrical tuning of quantum cascade lasers at 9.25 μm, 8.5 μm, and 4.4 μm in continuous wave operation using Vernier-effect distributed Bragg reflectors based on superstructure gratings. Integrated micro-heaters allow to switch from one Vernier channel to the other, while predictable and mode-hop free tuning can be obtained in each channel modulating the laser current with a side mode suppression ratio as high as 30 dB. The resulting device behaves effectively as a switchable multicolour tunable source. Tuning up to 6.5% of the central wavelength is observed. To prove the importance of the developed devices for high resolutionmore » molecular spectroscopy, a N{sub 2}O absorption spectrum has been measured.« less

Continuous production of fenofibrate solid lipid nanoparticles by hot-melt extrusion technology: a systematic study based on a quality by design approach.

PubMed

Patil, Hemlata; Feng, Xin; Ye, Xingyou; Majumdar, Soumyajit; Repka, Michael A

2015-01-01

This contribution describes a continuous process for the production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME). Presently, HME technology has not been used for the manufacturing of SLN. Generally, SLN are prepared as a batch process, which is time consuming and may result in variability of end-product quality attributes. In this study, using Quality by Design (QbD) principles, we were able to achieve continuous production of SLN by combining two processes: HME technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. Fenofibrate (FBT), a poorly water-soluble model drug, was incorporated into SLN using HME-HPH methods. The developed novel platform demonstrated better process control and size reduction compared to the conventional process of hot homogenization (batch process). Varying the process parameters enabled the production of SLN below 200 nm. The dissolution profile of the FBT SLN prepared by the novel HME-HPH method was faster than that of the crude FBT and a micronized marketed FBT formulation. At the end of a 5-h in vitro dissolution study, a SLN formulation released 92-93% of drug, whereas drug release was approximately 65 and 45% for the marketed micronized formulation and crude drug, respectively. Also, pharmacokinetic study results demonstrated a statistical increase in Cmax, Tmax, and AUC0-24 h in the rate of drug absorption from SLN formulations as compared to the crude drug and marketed micronized formulation. In summary, the present study demonstrated the potential use of hot-melt extrusion technology for continuous and large-scale production of SLN.

A Process Evaluation of Project Developmental Continuity. Interim Report II, Part A: Program Case Studies. Volume 2.

ERIC Educational Resources Information Center

Spencer, Lynn, Ed.

These 7 case studies are part of a series of documents on the evaluation of Project Developmental Continuity (PDC), a Head Start demonstration program aimed at providing educational and developmental continuity between children's Head Start and primary school experiences. Each case study reviews the planning year at a PDC demonstration site in one…

A Process Evaluation of Project Developmental Continuity. Interim Report II, Part A: Program Case Studies. Volume I.

ERIC Educational Resources Information Center

Spencer, Lynn, Ed.

These 8 case studies are part of a series of documents on the evaluation of Project Developmental Continuity (PDC), a Head Start demonstration program aimed at providing educational and developmental continuity between children's Head Start and primary school experiences. Each case study reviews the planning year at a PDC demonstration site in one…

40 CFR 63.7333 - How do I demonstrate continuous compliance with the emission limitations that apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Pollutants for Coke Ovens: Pushing, Quenching, and Battery Stacks Continuous Compliance Requirements § 63... compliance is required under § 63.7283, you must demonstrate continuous compliance for each by-product coke... coke at 1,100 mg/L or less; and (2) Determining the TDS content of the quench water at least weekly...

40 CFR 63.7333 - How do I demonstrate continuous compliance with the emission limitations that apply to me?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Pollutants for Coke Ovens: Pushing, Quenching, and Battery Stacks Continuous Compliance Requirements § 63... compliance is required under § 63.7283, you must demonstrate continuous compliance for each by-product coke... coke at 1,100 mg/L or less; and (2) Determining the TDS content of the quench water at least weekly...

40 CFR 63.7333 - How do I demonstrate continuous compliance with the emission limitations that apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Pollutants for Coke Ovens: Pushing, Quenching, and Battery Stacks Continuous Compliance Requirements § 63... compliance is required under § 63.7283, you must demonstrate continuous compliance for each by-product coke... coke at 1,100 mg/L or less; and (2) Determining the TDS content of the quench water at least weekly...

40 CFR 63.7333 - How do I demonstrate continuous compliance with the emission limitations that apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Pollutants for Coke Ovens: Pushing, Quenching, and Battery Stacks Continuous Compliance Requirements § 63... compliance is required under § 63.7283, you must demonstrate continuous compliance for each by-product coke... coke at 1,100 mg/L or less; and (2) Determining the TDS content of the quench water at least weekly...

40 CFR 63.7333 - How do I demonstrate continuous compliance with the emission limitations that apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Pollutants for Coke Ovens: Pushing, Quenching, and Battery Stacks Continuous Compliance Requirements § 63... compliance is required under § 63.7283, you must demonstrate continuous compliance for each by-product coke... coke at 1,100 mg/L or less; and (2) Determining the TDS content of the quench water at least weekly...

40 CFR Appendix G to Part 60 - Provisions for an Alternative Method of Demonstrating Compliance With 40 CFR 60.43 for the Newton...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Company G Appendix G to Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES (CONTINUED) Pt. 60, App. G Appendix G to Part 60—Provisions for an Alternative Method of Demonstrating Compliance With 40 CFR 60.43...

40 CFR Appendix G to Part 60 - Provisions for an Alternative Method of Demonstrating Compliance With 40 CFR 60.43 for the Newton...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Company G Appendix G to Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES (CONTINUED) Pt. 60, App. G Appendix G to Part 60—Provisions for an Alternative Method of Demonstrating Compliance With 40 CFR 60.43...

40 CFR Appendix G to Part 60 - Provisions for an Alternative Method of Demonstrating Compliance With 40 CFR 60.43 for the Newton...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Company G Appendix G to Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES (CONTINUED) Pt. 60, App. G Appendix G to Part 60—Provisions for an Alternative Method of Demonstrating Compliance With 40 CFR 60.43...

Application of a continuously stirred tank bioreactor (CSTR) for bioremediation of hydrocarbon-rich industrial wastewater effluents.

PubMed

Gargouri, Boutheina; Karray, Fatma; Mhiri, Najla; Aloui, Fathi; Sayadi, Sami

2011-05-15

A continuously stirred tank bioreactor (CSTR) was used to optimize feasible and reliable bioprocess system in order to treat hydrocarbon-rich industrial wastewaters. A successful bioremediation was developed by an efficient acclimatized microbial consortium. After an experimental period of 225 days, the process was shown to be highly efficient in decontaminating the wastewater. The performance of the bioaugmented reactor was demonstrated by the reduction of COD rates up to 95%. The residual total petroleum hydrocarbon (TPH) decreased from 320 mg TPH l(-1) to 8 mg TPH l(-1). Analysis using gas chromatography-mass spectrometry (GC-MS) identified 26 hydrocarbons. The use of the mixed cultures demonstrated high degradation performance for hydrocarbons range n-alkanes (C10-C35). Six microbial isolates from the CSTR were characterized and species identification was confirmed by sequencing the 16S rRNA genes. The partial 16S rRNA gene sequences demonstrated that 5 strains were closely related to Aeromonas punctata (Aeromonas caviae), Bacillus cereus, Ochrobactrum intermedium, Stenotrophomonas maltophilia and Rhodococcus sp. The 6th isolate was affiliated to genera Achromobacter. Besides, the treated wastewater could be considered as non toxic according to the phytotoxicity test since the germination index of Lepidium sativum ranged between 57 and 95%. The treatment provided satisfactory results and presents a feasible technology for the treatment of hydrocarbon-rich wastewater from petrochemical industries and petroleum refineries. Copyright © 2011 Elsevier B.V. All rights reserved.

Still at Risk: What Students Don't Know, Even Now--A Report from Common Core

ERIC Educational Resources Information Center

Hess, Frederick M.

2009-01-01

A report from Common Core finds that many of America's high school students do not possess the basic knowledge they need to succeed in the world. The report shows that, twenty-five years after the publication of the landmark study, "A Nation at Risk," America's children continue to demonstrate a stunning ignorance about basic facts of America's…

An advanced Ni-Cd battery cell design

NASA Technical Reports Server (NTRS)

Miller, L.

1986-01-01

The evolution of an advanced Ni-Cd space battery cell design continues to prove very promising. High oxygen/hydrogen gas recombination rates (currently up to a C/5 charge rate) and increased electrolyte activation level tolerance (currently up to 5.6 grams Ah of positive capacity) were demonstrated by test. A superior performance, extended life battery cell offering advantages should soon be available for mission applications

Feasibility of Applying Ohmic Heating and Split-Phase Aseptic Processing for Ration Entree Preservation

DTIC Science & Technology

1994-08-01

study demonstrated that either of these reduced- temperature sterilization processes will produce an acceptable product that is an alternative to thermal...and uniform heating of liquids and solids simultaneously, even of large particles, up to sterilization temperatures . Uniform heating means shorter...potential cost reduction by substitution of continuous processing of a high- temperature /short-time ( HTST ) nature for traditional batch retort

High-Rate Field Demonstration of Large-Alphabet Quantum Key Distribution

DTIC Science & Technology

2017-05-22

QKD, 2015 MDI−QKD, 2016 CV/GMCS, 2016 BBM92, 2009 COW , 2015 This work Figure 4: Comparison of our P&M DO-QKD results to previously published QKD system...device-independent QKD (39). CV/GMCS: distance record for continuous-variable QKD (40). BBM92: secure throughput record for two-dimensional entanglement-based QKD (41). COW : distance record for QKD (20). 17

40 CFR 63.7911 - How do I demonstrate initial compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7911 How do I demonstrate initial...

40 CFR 63.7911 - How do I demonstrate initial compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7911 How do I demonstrate initial...

40 CFR 63.7891 - How do I demonstrate initial compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Process Vents § 63.7891 How do I demonstrate...

40 CFR 63.7911 - How do I demonstrate initial compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7911 How do I demonstrate initial...

40 CFR 63.7911 - How do I demonstrate initial compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7911 How do I demonstrate initial...

40 CFR 63.7911 - How do I demonstrate initial compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7911 How do I demonstrate initial...

40 CFR 63.7921 - How do I demonstrate initial compliance with the emissions limitations and work practice...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Equipment Leaks § 63.7921 How do I demonstrate...

Taurine supplementation increases skeletal muscle force production and protects muscle function during and after high-frequency in vitro stimulation.

PubMed

Goodman, Craig A; Horvath, Deanna; Stathis, Christos; Mori, Trevor; Croft, Kevin; Murphy, Robyn M; Hayes, Alan

2009-07-01

Recent studies report that depletion and repletion of muscle taurine (Tau) to endogenous levels affects skeletal muscle contractility in vitro. In this study, muscle Tau content was raised above endogenous levels by supplementing male Sprague-Dawley rats with 2.5% (wt/vol) Tau in drinking water for 2 wk, after which extensor digitorum longus (EDL) muscles were examined for in vitro contractile properties, fatigue resistance, and recovery from fatigue after two different high-frequency stimulation bouts. Tau supplementation increased muscle Tau content by approximately 40% and isometric twitch force by 19%, shifted the force-frequency relationship upward and to the left, increased specific force by 4.2%, and increased muscle calsequestrin protein content by 49%. Force at the end of a 10-s (100 Hz) continuous tetanic stimulation was 6% greater than controls, while force at the end of the 3-min intermittent high-frequency stimulation bout was significantly higher than controls, with a 12% greater area under the force curve. For 1 h after the 10-s continuous stimulation, tetanic force in Tau-supplemented muscles remained relatively stable while control muscle force gradually deteriorated. After the 3-min intermittent bout, tetanic force continued to slowly recover over the next 1 h, while control muscle force again began to decline. Tau supplementation attenuated F(2)-isoprostane production (a sensitive indicator of reactive oxygen species-induced lipid peroxidation) during the 3-min intermittent stimulation bout. Finally, Tau transporter protein expression was not altered by the Tau supplementation. Our results demonstrate that raising Tau content above endogenous levels increases twitch and subtetanic and specific force in rat fast-twitch skeletal muscle. Also, we demonstrate that raising Tau protects muscle function during high-frequency in vitro stimulation and the ensuing recovery period and helps reduce oxidative stress during prolonged stimulation.

Recombinant factor VIII Fc fusion protein for immune tolerance induction in patients with severe haemophilia A with inhibitors-A retrospective analysis.

PubMed

Carcao, M; Shapiro, A; Staber, J M; Hwang, N; Druzgal, C; Lieuw, K; Belletrutti, M; Thornburg, C D; Ahuja, S P; Morales-Arias, J; Dumont, J; Miyasato, G; Tsao, E; Jain, N; Pipe, S W

2018-03-01

Immune tolerance induction (ITI) is the gold standard for eradication of factor VIII inhibitors in severe haemophilia A; however, it usually requires treatment for extended periods with associated high burden on patients and healthcare resources. Review outcomes of ITI with recombinant factor VIII Fc fusion protein (rFVIIIFc) in patients with severe haemophilia A and high-titre inhibitors. Multicentre retrospective chart review of severe haemophilia A patients treated with rFVIIIFc for ITI. Of 19 patients, 7 were first-time ITI and 12 were rescue ITI. Of 7 first-time patients, 6 had at least 1 high-risk feature for ITI failure. Four of 7 first-time patients were tolerized in a median of 7.8 months. The remaining 3 patients continue on rFVIIIFc ITI. Of 12 rescue patients, 7 initially achieved a negative Bethesda titre (≤0.6) in a median of 3.3 months, 1 had a decrease in Bethesda titre and continues on rFVIIIFc ITI and 4 have not demonstrated a decrease in Bethesda titre. Of these 4, 3 continue on rFVIIIFc ITI and 1 switched to bypass therapy alone. Two initially responsive patients transitioned to other factors due to recurrence. Overall, 16 of 19 patients remain on rFVIIIFc (prophylaxis or ITI). For those still undergoing ITI, longer follow-up is needed to determine final outcomes. No adverse events reported. Recombinant factor VIII Fc fusion protein demonstrated rapid time to tolerization in high-risk first-time ITI patients. For rescue ITI, rFVIIIFc showed therapeutic benefit in some patients who previously failed ITI with other products. These findings highlight the need to further evaluate the use of rFVIIIFc for ITI. © 2018 The Authors. Haemophilia Published by John Wiley & Sons Ltd.

Current Status of Concentrator Photovoltaic (CPV) Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Philipps, Simon P.; Bett, Andreas W.; Horowitz, Kelsey

2015-12-01

This report summarizes the status of the concentrator photovoltaic (CPV) market and industry as well as current trends in research and technology. This report is intended to guide research agendas for Fraunhofer ISE, the National Renewable Energy Laboratory (NREL), and other R&D organizations. Version 1.1 of this report includes recent progress in CPV. The recent record module efficiency of 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9%more » at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve.« less

Chemistry, physics and time: the computer modelling of glassmaking.

PubMed

Martlew, David

2003-01-01

A decade or so ago the remains of an early flat glass furnace were discovered in St Helens. Continuous glass production only became feasible after the Siemens Brothers demonstrated their continuous tank furnace at Dresden in 1870. One manufacturer of flat glass enthusiastically adopted the new technology and secretly explored many variations on this theme during the next fifteen years. Study of the surviving furnace remains using today's computer simulation techniques showed how, in 1887, that technology was adapted to the special demands of window glass making. Heterogeneous chemical reactions at high temperatures are required to convert the mixture of granular raw materials into the homogeneous glass needed for windows. Kinetics (and therefore the economics) of glassmaking is dominated by heat transfer and chemical diffusion as refractory grains are converted to highly viscous molten glass. Removal of gas bubbles in a sufficiently short period of time is vital for profitability, but the glassmaker must achieve this in a reaction vessel which is itself being dissolved by the molten glass. Design and operational studies of today's continuous tank furnaces need to take account of these factors, and good use is made of computer simulation techniques to shed light on the way furnaces behave and how improvements may be made. This paper seeks to show how those same techniques can be used to understand how the early Siemens continuous tank furnaces were designed and operated, and how the Victorian entrepreneurs succeeded in managing the thorny problems of what was, in effect, a vulnerable high temperature continuous chemical reactor.

The development of coal-based technologies for Department of Defense facilities. Volume 1, Technical report. Semiannual technical progress report, September 28, 1994--March 27, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, B.G.; Bartley, D.A.; Hatcher, P.

1996-10-15

This program is being conducted as a cooperative agreement between the Consortium for Coal Water Mixture Technology and the U.S. Department of Energy. Activities this reporting period are summarized by phase. Phase I is nearly completed. During this reporting period, coal beneficiation/preparation studies, engineering designs and economics for retrofitting the Crane, Indiana boiler to fire coal-based fuels, and a 1,000-hour demonstration of dry, micronized coal were completed. In addition, a demonstration-scale micronized-coal water mixture (MCWM) preparation circuit was constructed and a 1,000-hour demonstration firing MCWM began. Work in Phase II focused on emissions reductions, coal beneficiation/preparation studies, and economic analysesmore » of coal use. Emissions reductions investigations involved literature surveys of NO{sub x}, SO{sub 2}, trace metals, volatile organic compounds, and fine particulate matter capture. In addition, vendors and engineering firms were contacted to identify the appropriate emissions technologies for the installation of commercial NO{sub x} and SO{sub 2} removal systems on the demonstration boiler. Information from the literature surveys and engineering firms will be used to identify, design, and install a control system(s). Work continued on the refinement and optimization of coal grinding and MCWM preparation procedures, and on the development of advanced processes for beneficiating high ash, high sulfur coals. Work also continued on determining the basic cost estimation of boiler retrofits, and evaluating environmental, regulatory, and regional economic impacts. In addition, the feasibility of technology adoption, and the public`s perception of the benefits and costs of coal usage was studied. A coal market analysis was completed. Work in Phase III focused on coal preparation studies, emissions reductions and economic analyses of coal use.« less

Airspace Technology Demonstration 3 (ATD-3): Dynamic Weather Routes (DWR) Technology Transfer Document Summary Version 1.0

NASA Technical Reports Server (NTRS)

Sheth, Kapil; Wang, Easter Mayan Chan

2016-01-01

Airspace Technology Demonstration #3 (ATD-3) is part of NASA's Airspace Operations and Safety Program (AOSP) - specifically, its Airspace Technology Demonstrations (ATD) Project. ATD-3 is a multiyear research and development effort which proposes to develop and demonstrate automation technologies and operating concepts that enable air navigation service providers and airspace users to continuously assess weather, winds, traffic, and other information to identify, evaluate, and implement workable opportunities for flight plan route corrections that can result in significant flight time and fuel savings in en route airspace. In order to ensure that the products of this tech-transfer are relevant and useful, NASA has created strong partnerships with the FAA and key industry stakeholders. This summary document and accompanying technology artifacts satisfy the first of three Research Transition Products (RTPs) defined in the Applied Traffic Flow Management (ATFM) Research Transition Team (RTT) Plan. This transfer consists of NASA's legacy Dynamic Weather Routes (DWR) work for efficient routing for en-route weather avoidance. DWR is a ground-based trajectory automation system that continuously and automatically analyzes active airborne aircraft in en route airspace to identify opportunities for simple corrections to flight plan routes that can save significant flying time, at least five minutes wind-corrected, while avoiding weather and considering traffic conflicts, airspace sector congestion, special use airspace, and FAA routing restrictions. The key benefit of the DWR concept is to let automation continuously and automatically analyze active flights to find those where simple route corrections can save significant time and fuel. Operators are busy during weather events. It is more effective to let automation find the opportunities for high-value route corrections.

Real-time high-resolution heterodyne-based measurements of spectral dynamics in fibre lasers

PubMed Central

Sugavanam, Srikanth; Fabbri, Simon; Le, Son Thai; Lobach, Ivan; Kablukov, Sergey; Khorev, Serge; Churkin, Dmitry

2016-01-01

Conventional tools for measurement of laser spectra (e.g. optical spectrum analysers) capture data averaged over a considerable time period. However, the generation spectrum of many laser types may involve spectral dynamics whose relatively fast time scale is determined by their cavity round trip period, calling for instrumentation featuring both high temporal and spectral resolution. Such real-time spectral characterisation becomes particularly challenging if the laser pulses are long, or they have continuous or quasi-continuous wave radiation components. Here we combine optical heterodyning with a technique of spatio-temporal intensity measurements that allows the characterisation of such complex sources. Fast, round-trip-resolved spectral dynamics of cavity-based systems in real-time are obtained, with temporal resolution of one cavity round trip and frequency resolution defined by its inverse (85 ns and 24 MHz respectively are demonstrated). We also show how under certain conditions for quasi-continuous wave sources, the spectral resolution could be further increased by a factor of 100 by direct extraction of phase information from the heterodyned dynamics or by using double time scales within the spectrogram approach. PMID:26984634

Renewable Wood Pulp Paper Reactor with Hierarchical Micro/Nanopores for Continuous-Flow Nanocatalysis.

PubMed

Koga, Hirotaka; Namba, Naoko; Takahashi, Tsukasa; Nogi, Masaya; Nishina, Yuta

2017-06-22

Continuous-flow nanocatalysis based on metal nanoparticle catalyst-anchored flow reactors has recently provided an excellent platform for effective chemical manufacturing. However, there has been limited progress in porous structure design and recycling systems for metal nanoparticle-anchored flow reactors to create more efficient and sustainable catalytic processes. In this study, traditional paper is used for a highly efficient, recyclable, and even renewable flow reactor by tailoring the ultrastructures of wood pulp. The "paper reactor" offers hierarchically interconnected micro- and nanoscale pores, which can act as convective-flow and rapid-diffusion channels, respectively, for efficient access of reactants to metal nanoparticle catalysts. In continuous-flow, aqueous, room-temperature catalytic reduction of 4-nitrophenol to 4-aminophenol, a gold nanoparticle (AuNP)-anchored paper reactor with hierarchical micro/nanopores provided higher reaction efficiency than state-of-the-art AuNP-anchored flow reactors. Inspired by traditional paper materials, successful recycling and renewal of AuNP-anchored paper reactors were also demonstrated while high reaction efficiency was maintained. © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Implementation of Ultrasonic Sensing for High Resolution Measurement of Binary Gas Mixture Fractions

PubMed Central

Bates, Richard; Battistin, Michele; Berry, Stephane; Bitadze, Alexander; Bonneau, Pierre; Bousson, Nicolas; Boyd, George; Bozza, Gennaro; Crespo-Lopez, Olivier; Riva, Enrico Da; Degeorge, Cyril; Deterre, Cecile; DiGirolamo, Beniamino; Doubek, Martin; Favre, Gilles; Godlewski, Jan; Hallewell, Gregory; Hasib, Ahmed; Katunin, Sergey; Langevin, Nicolas; Lombard, Didier; Mathieu, Michel; McMahon, Stephen; Nagai, Koichi; Pearson, Benjamin; Robinson, David; Rossi, Cecilia; Rozanov, Alexandre; Strauss, Michael; Vitek, Michal; Vacek, Vaclav; Zwalinski, Lukasz

2014-01-01

We describe an ultrasonic instrument for continuous real-time analysis of the fractional mixture of a binary gas system. The instrument is particularly well suited to measurement of leaks of a high molecular weight gas into a system that is nominally composed of a single gas. Sensitivity < 5 × 10−5 is demonstrated to leaks of octaflouropropane (C3F8) coolant into nitrogen during a long duration (18 month) continuous study. The sensitivity of the described measurement system is shown to depend on the difference in molecular masses of the two gases in the mixture. The impact of temperature and pressure variances on the accuracy of the measurement is analysed. Practical considerations for the implementation and deployment of long term, in situ ultrasonic leak detection systems are also described. Although development of the described systems was motivated by the requirements of an evaporative fluorocarbon cooling system, the instrument is applicable to the detection of leaks of many other gases and to processes requiring continuous knowledge of particular binary gas mixture fractions. PMID:24961217

Down-Bore Two-Laser Heterodyne Velocimetry of an Implosion-Driven Hypervelocity Launcher

NASA Astrophysics Data System (ADS)

Hildebrand, Myles; Huneault, Justin; Loiseau, Jason; Higgins, Andrew J.

2015-06-01

The implosion-driven launcher uses explosives to shock-compress helium, driving well-characterized projectiles to velocities exceeding 10 km/s. The masses of projectiles range between 0.1 - 10 g, and the design shows excellent scalability, reaching similar velocities across different projectile sizes. In the past, velocity measurements have been limited to muzzle velocity obtained via a high-speed videography upon the projectile exiting the launch tube. Recently, Photonic Doppler Velocimetry (PDV) has demonstrated the ability to continuously measure in-bore velocity, even in the presence of significant blow-by of high temperature helium propellant past the projectile. While a single-laser PDV is limited to approximately 8 km/s, a two-laser PDV system is developed that uses two lasers operating near 1550 nm to provide velocity measurement capabilities up to 16 km/s. The two laser PDV system is used to obtain a continuous velocity history of the projectile throughout the entire launch cycle. These continuous velocity data are used to validate models of the launcher cycle and compare different advanced concepts aimed at increasing the projectile velocity to well beyond 10 km/s.

Advanced photoinjector experiment photogun commissioning results

NASA Astrophysics Data System (ADS)

Sannibale, F.; Filippetto, D.; Papadopoulos, C. F.; Staples, J.; Wells, R.; Bailey, B.; Baptiste, K.; Corlett, J.; Cork, C.; De Santis, S.; Dimaggio, S.; Doolittle, L.; Doyle, J.; Feng, J.; Garcia Quintas, D.; Huang, G.; Huang, H.; Kramasz, T.; Kwiatkowski, S.; Lellinger, R.; Moroz, V.; Norum, W. E.; Padmore, H.; Pappas, C.; Portmann, G.; Vecchione, T.; Vinco, M.; Zolotorev, M.; Zucca, F.

2012-10-01

The Advanced Photoinjector Experiment (APEX) at the Lawrence Berkeley National Laboratory is dedicated to the development of a high-brightness high-repetition rate (MHz-class) electron injector for x-ray free-electron laser (FEL) and other applications where high repetition rates and high brightness are simultaneously required. The injector is based on a new concept rf gun utilizing a normal-conducting (NC) cavity resonating in the VHF band at 186 MHz, and operating in continuous wave (cw) mode in conjunction with high quantum efficiency photocathodes capable of delivering the required charge at MHz repetition rates with available laser technology. The APEX activities are staged in three phases. In phase 0, the NC cw gun is built and tested to demonstrate the major milestones to validate the gun design and performance. Also, starting in phase 0 and continuing in phase I, different photocathodes are tested at the gun energy and at full repetition rate for validating candidate materials to operate in a high-repetition rate FEL. In phase II, a room-temperature pulsed linac is added for accelerating the beam at several tens of MeV to reduce space charge effects and allow the measurement of the brightness of the beam from the gun when integrated in an injector scheme. The installation of the phase 0 beam line and the commissioning of the VHF gun are completed, phase I components are under fabrication, and initial design and specification of components and layout for phase II are under way. This paper presents the phase 0 commissioning results with emphasis on the experimental milestones that have successfully demonstrated the APEX gun capability of operating at the required performance.

A spectrally tunable all-graphene-based flexible field-effect light-emitting device

PubMed Central

Wang, Xiaomu; Tian, He; Mohammad, Mohammad Ali; Li, Cheng; Wu, Can; Yang, Yi; Ren, Tian-Ling

2015-01-01

The continuous tuning of the emission spectrum of a single light-emitting diode (LED) by an external electrical bias is of great technological significance as a crucial property in high-quality displays, yet this capability has not been demonstrated in existing LEDs. Graphene, a tunable optical platform, is a promising medium to achieve this goal. Here we demonstrate a bright spectrally tunable electroluminescence from blue (∼450 nm) to red (∼750 nm) at the graphene oxide/reduced-graphene oxide interface. We explain the electroluminescence results from the recombination of Poole–Frenkel emission ionized electrons at the localized energy levels arising from semi-reduced graphene oxide, and holes from the top of the π band. Tuning of the emission wavelength is achieved by gate modulation of the participating localized energy levels. Our demonstration of current-driven tunable LEDs not only represents a method for emission wavelength tuning but also may find applications in high-quality displays. PMID:26178323

Photon energy upconversion through thermal radiation with the power efficiency reaching 16%.

PubMed

Wang, Junxin; Ming, Tian; Jin, Zhao; Wang, Jianfang; Sun, Ling-Dong; Yan, Chun-Hua

2014-11-28

The efficiency of many solar energy conversion technologies is limited by their poor response to low-energy solar photons. One way for overcoming this limitation is to develop materials and methods that can efficiently convert low-energy photons into high-energy ones. Here we show that thermal radiation is an attractive route for photon energy upconversion, with efficiencies higher than those of state-of-the-art energy transfer upconversion under continuous wave laser excitation. A maximal power upconversion efficiency of 16% is achieved on Yb(3+)-doped ZrO2. By examining various oxide samples doped with lanthanide or transition metal ions, we draw guidelines that materials with high melting points, low thermal conductivities and strong absorption to infrared light deliver high upconversion efficiencies. The feasibility of our upconversion approach is further demonstrated under concentrated sunlight excitation and continuous wave 976-nm laser excitation, where the upconverted white light is absorbed by Si solar cells to generate electricity and drive optical and electrical devices.

Engineering non-linear resonator mode interactions in circuit QED by continuous driving: Manipulation of a photonic quantum memory

NASA Astrophysics Data System (ADS)

Reagor, Matthew; Pfaff, Wolfgang; Heeres, Reinier; Ofek, Nissim; Chou, Kevin; Blumoff, Jacob; Leghtas, Zaki; Touzard, Steven; Sliwa, Katrina; Holland, Eric; Albert, Victor V.; Frunzio, Luigi; Devoret, Michel H.; Jiang, Liang; Schoelkopf, Robert J.

2015-03-01

Recent advances in circuit QED have shown great potential for using microwave resonators as quantum memories. In particular, it is possible to encode the state of a quantum bit in non-classical photonic states inside a high-Q linear resonator. An outstanding challenge is to perform controlled operations on such a photonic state. We demonstrate experimentally how a continuous drive on a transmon qubit coupled to a high-Q storage resonator can be used to induce non-linear dynamics of the resonator. Tailoring the drive properties allows us to cancel or enhance non-linearities in the system such that we can manipulate the state stored in the cavity. This approach can be used to either counteract undesirable evolution due to the bare Hamiltonian of the system or, ultimately, to perform logical operations on the state encoded in the cavity field. Our method provides a promising pathway towards performing universal control for quantum states stored in high-coherence resonators in the circuit QED platform.

A reliable sealing method for microbatteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Yuxing; Cartmell, Samuel; Li, Qiuyan

2017-02-01

With continuous downsizing of electronic devices, lithium batteries of traditional shapes cannot meet the demand where small-size high energy density batteries are needed. Conventional sealing methods become increasingly difficult to apply and impose high processing cost as the size of batteries decreases. In this report, a facile sealing method is proposed and demonstrated in CFx/Li mini-batteries. The method employs a temporary barrier to liquid electrolytes while relies on the epoxies/cell casings bond for the hermetic sealing. Cells sealed by this method show no degradation for an extended period of storage time.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scaglione, John M; Montgomery, Rose; Bevard, Bruce Balkcom

This test plan describes the experimental work to be implemented by the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE) to characterize high burnup (HBU) spent nuclear fuel (SNF) in conjunction with the High Burnup Dry Storage Cask Research and Development Project and serves to coordinate and integrate the multi-year experimental program to collect and develop data regarding the continued storage and eventual transport of HBU (i.e., >45 GWd/MTU) SNF. The work scope involves the development, performance, technical integration, and oversight of measurements and collection of relevant data, guided by analyses and demonstration of need.

Dynamic design and control of a high-speed pneumatic jet actuator

NASA Astrophysics Data System (ADS)

Misyurin, S. Yu; Ivlev, V. I.; Kreinin, G. V.

2017-12-01

Mathematical model of an actuator, consisting of a pneumatic (gas) high-speed jet engine, transfer mechanism, and a control device used for switching the ball valve is worked out. The specific attention was paid to the transition (normalization) of the dynamic model into the dimensionless form. Its dynamic simulation criteria are determined, and dynamics study of an actuator was carried out. The simple control algorithm of relay action with a velocity feedback enabling the valve plug to be turned with a smooth nonstop and continuous approach to the final position is demonstrated

High Temperature Falling Particle Receiver (2012 - 2016) - Final DOE Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ho, Clifford K.

The objective of this work was to advance falling particle receiver designs for concentrating solar power applications that will enable higher temperatures (>700 °C) and greater power-cycle efficiencies (≥50% thermal-to-electric). Modeling, design, and testing of components in Phases 1 and 2 led to the successful on-sun demonstration in Phase 3 of the world’s first continuously recirculating high-temperature 1 MW t falling particle receiver that achieved >700 °C particle outlet temperatures at mass flow rates ranging from 1 – 7 kg/s.

Development of a highly-sensitive Penning ionization electron spectrometer using the magnetic bottle effect

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ota, Masahiro; Ishiguro, Yuki; Nakajima, Yutaro

2016-02-01

This paper reports on a highly-sensitive retarding-type electron spectrometer for a continuous source of electrons, in which the electron collection efficiency is increased by utilizing the magnetic bottle effect. This study demonstrates an application to Penning ionization electron spectroscopy using collisional ionization with metastable He*(2{sup 3}S) atoms. Technical details and performances of the instrument are presented. This spectrometer can be used for studies of functional molecules and assemblies, and exterior electron densities are expected to be selectively observed by the Penning ionization.

Laser-filamentation-induced condensation and snow formation in a cloud chamber.

PubMed

Ju, Jingjing; Liu, Jiansheng; Wang, Cheng; Sun, Haiyi; Wang, Wentao; Ge, Xiaochun; Li, Chuang; Chin, See Leang; Li, Ruxin; Xu, Zhizhan

2012-04-01

Using 1 kHz, 9 mJ femtosecond laser pulses, we demonstrate laser-filamentation-induced spectacular snow formation in a cloud chamber. An intense updraft of warm moist air is generated owing to the continuous heating by the high-repetition filamentation. As it encounters the cold air above, water condensation and large-sized particles spread unevenly across the whole cloud chamber via convection and cyclone like action on a macroscopic scale. This indicates that high-repetition filamentation plays a significant role in macroscopic laser-induced water condensation and snow formation.

40 CFR 60.2700 - How do I demonstrate initial compliance with the amended emission limitations and establish the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF... Solid Waste Incineration Units Model Rule-Initial Compliance Requirements § 60.2700 How do I demonstrate...

40 CFR 60.2700 - How do I demonstrate initial compliance with the amended emission limitations and establish the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF... Solid Waste Incineration Units Model Rule-Initial Compliance Requirements § 60.2700 How do I demonstrate...

Emerging Therapies in Metastatic Prostate Cancer.

PubMed

Sonnenburg, Daniel W; Morgans, Alicia K

2018-04-11

In the last decade, there have been multiple landmark therapeutic advances for the treatment of metastatic prostate cancer, both in the castration-resistant and hormone-sensitive setting. In this review, we highlight recent progress and ongoing trials for metastatic prostate cancer, including advances in chemotherapy, androgen receptor-directed therapy, targeted therapies, and immunotherapy. Several landmark studies for men with metastatic hormone-sensitive prostate cancer demonstrated improvement in overall survival with the addition of docetaxel chemotherapy or abiraterone acetate to standard androgen deprivation therapy. A single-arm phase 2 study of the PARP inhibitor olaparib demonstrated high response rates and more favorable progression-free and overall survival for men with metastatic castration-resistant prostate cancer and DNA repair defects treated with olaparib compared with men without DNA repair defects. Multiple ongoing clinical trials are investigating novel hormonal therapies and combinations of chemotherapy, targeted small molecules, immunotherapy, and radiopharmaceuticals. Progress continues to be made in the treatment of metastatic prostate cancer, and ongoing clinical trials continue to investigate novel agents and approaches to treatment.

Printing of small molecular medicines from the vapor phase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shalev, Olga; Raghavan, Shreya; Mazzara, J. Maxwell

There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor jet printing to deposit nanostructured films of small molecular pharmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluorescein, with accuracy on the scale of micrograms per square centimeter, onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles. The printed films exhibit similar crystallographic order and chemistry as the original powders; controlled, order-of-magnitude enhancements of dissolution rate are observed relative to powder-form particles. In vitromore » treatment of breast and ovarian cancer cell cultures in aqueous media by tamoxifen and BAY 11-7082 films shows similar behavior to drugs pre-dissolved in dimethyl sulfoxide. In conclusion, the demonstrated precise printing of medicines as films, without the use of solvents, can accelerate drug screening and enable continuous manufacturing, while enhancing dosage accuracy.« less

Widely bandwidth-tunable silicon filter with an unlimited free-spectral range.

PubMed

St-Yves, Jonathan; Bahrami, Hadi; Jean, Philippe; LaRochelle, Sophie; Shi, Wei

2015-12-01

Next-generation high-capacity optical networks require flexible allocation of spectrum resources, for which low-cost optical filters with an ultra-wide bandwidth tunability beyond 100 GHz are desired. We demonstrate an integrated band-pass filter with the bandwidth continuously tuned across 670 GHz (117-788 GHz) which, to the best of our knowledge, is the widest tuning span ever demonstrated on a silicon chip. The filter also features simultaneous wavelength tuning and an unlimited free spectral range. We measured an out-of-band contrast of up to 55 dB, low in-band ripples of less than 0.3 dB, and in-band group delay variation of less than 8 ps. This result was achieved using cascaded Bragg-grating-assisted contra-directional couplers and micro-heaters on the 220 nm silicon-on-insulator platform with a very compact footprint of less than 7000  μm2. Another design with the bandwidth continuously tunable from 50 GHz to 1 THz is also presented.

Clinical experience with trimegestone as a new progestin in HRT.

PubMed

Grubb, Gary; Spielmann, Daniele; Pickar, James; Constantine, Ginger

2003-11-01

Trimegestone (TMG) is a novel, 19-norpregnane progestin, which demonstrates endometrial selectivity with a reduced progestin-related side effect profile when compared to several other currently marketed progestins. TMG has been studied in combination with 17beta-estradiol (17beta-E2) and conjugated equine estrogens (CEE). TMG-containing HRT agents were effective in relieving vasomotor symptoms and providing protection from endometrial hyperplasia with < or =1% hyperplasia. In clinical trials with sequential regimens, TMG provided predictable withdrawal bleeding associated with a low incidence of irregular and prolonged bleeding. Clinical studies of continuous combined regimens of estrogen/TMG combinations demonstrated high levels of amenorrhea. Both 17beta-E2 and CEE/TMG combinations have shown improved bone mineral density and quality-of-life assessments. Both continuous combined and sequential regimens of 17beta-E2/TMG and CEE/TMG have a favorable clinical profile. TMG provides an important new option for the treatment of postmenopausal symptoms and the prevention of osteoporosis.

Multi-dimensional construction of a novel active yolk@conductive shell nanofiber web as a self-standing anode for high-performance lithium-ion batteries

NASA Astrophysics Data System (ADS)

Liu, Hao; Chen, Luyi; Liang, Yeru; Fu, Ruowen; Wu, Dingcai

2015-11-01

A novel active yolk@conductive shell nanofiber web with a unique synergistic advantage of various hierarchical nanodimensional objects including the 0D monodisperse SiO2 yolks, the 1D continuous carbon shell and the 3D interconnected non-woven fabric web has been developed by an innovative multi-dimensional construction method, and thus demonstrates excellent electrochemical properties as a self-standing LIB anode.A novel active yolk@conductive shell nanofiber web with a unique synergistic advantage of various hierarchical nanodimensional objects including the 0D monodisperse SiO2 yolks, the 1D continuous carbon shell and the 3D interconnected non-woven fabric web has been developed by an innovative multi-dimensional construction method, and thus demonstrates excellent electrochemical properties as a self-standing LIB anode. Electronic supplementary information (ESI) available: Experimental details and additional information about material characterization. See DOI: 10.1039/c5nr06531c

Three immobilized-cell columnar bioreactors for enhanced production of commodity chemicals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davison, B.H.; Scott, C.D.; Kaufman, E.N.

1993-07-01

Immobilized-cell fluidized-bed bioreactors (FBRS) can be used with a variety of fermentations to increase production of fuels, solvents, organic acids, and other fermentation products. Part of the increased rates and yields are due to the immobilization of the biocatalyst at high concentrations. This FBR system with immobilized Zymomonas mobiles increased ethanol productivity more than tenfold with 99% conversion and near stoichiometric yields. FBRs also offer several additional modes of operation for simultaneous fermentation and separation to further increase production by removing the inhibitory products directly from the continuous fermentation. The production of lactic acid by immobilized Lactobacillus was augmented withmore » the addition and removal of solid adsorbent particles to the FBR. An immiscible organic extractant also was used to extract butanol from the acetone-butanol fermentation by Clostridium acetobutylicum. Demonstrations with these FBR systems have already shown definite advantages by improved overall product yields (decreasing feed costs) and by increased rates (decreasing capital and operating costs). Further demonstration and scale-up continue.« less

Three immobilized-cell columnar bioreactors for enhanced production of commodity chemicals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davison, B.H.; Scott, C.D.; Kaufman, E.N.

1993-12-31

Immobilized-cell fluidized-bed bioreactors (FBRs) can be used with a variety of fermentations to increase production of fuels, solvents, organic acids, and other fermentation products. Part of the increased rates and yields are due to the immobilization of the biocatalyst at high concentrations. This FBR system with immobilized Zymomonas mobilis increased ethanol productivity more than tenfold with 99% conversion and near stoichiometric yields. FBRs also offer several additional modes of operation for simultaneous fermentation and separation to further increase production by removing the inhibitory products directly from the continuous fermentation. The production of lactic acid by immobilized Lactobacillus was augmented withmore » the addition and removal of solid adsorbent particles to the FBR. An immiscible organic extractant also was used to extract butanol from the acetone-butanol fermentation by Clostridium acetobutylicum. Demonstrations with these FBR systems have already shown definite advantages by improved overall product yields (decreasing feed costs) and by increased rates (decreasing capital and operating costs). Further demonstration and scale-up continue.« less

Printing of small molecular medicines from the vapor phase

DOE PAGES

Shalev, Olga; Raghavan, Shreya; Mazzara, J. Maxwell; ...

2017-09-27

There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor jet printing to deposit nanostructured films of small molecular pharmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluorescein, with accuracy on the scale of micrograms per square centimeter, onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles. The printed films exhibit similar crystallographic order and chemistry as the original powders; controlled, order-of-magnitude enhancements of dissolution rate are observed relative to powder-form particles. In vitromore » treatment of breast and ovarian cancer cell cultures in aqueous media by tamoxifen and BAY 11-7082 films shows similar behavior to drugs pre-dissolved in dimethyl sulfoxide. In conclusion, the demonstrated precise printing of medicines as films, without the use of solvents, can accelerate drug screening and enable continuous manufacturing, while enhancing dosage accuracy.« less

All-fiber Mach-Zehnder interferometer for tunable two quasi-continuous points' temperature sensing in seawater.

PubMed

Liu, Tianqi; Wang, Jing; Liao, Yipeng; Wang, Xin; Wang, Shanshan

2018-04-30

An all-fiber Mach-Zehnder interferometer (MZI) for two quasi-continuous points' temperature sensing in seawater is proposed. Based on the beam propagation theory, transmission spectrum is designed to present two sets of clear and independent interferences. Following this design, MZI is fabricated and two points' temperature sensing in seawater are demonstrated with sensitivities of 42.69pm/°C and 39.17pm/°C, respectively. By further optimization, sensitivity of 80.91pm/°C can be obtained, which is 3-10 times higher than fiber Bragg gratings and microfiber resonator, and higher than almost all similar MZI based temperature sensors. In addition, factors affecting sensitivities are also discussed and verified in experiment. The two points' temperature sensing demonstrated here show advantages of simple and compact construction, robust structure, easy fabrication, high sensitivity, immunity to salinity and tunable distance of 1-20 centimeters between two points, which may provide references for macroscopic oceanic research and other sensing applications based on MZIs.

20 kHz toluene planar laser-induced fluorescence imaging of a jet in nearly sonic crossflow

NASA Astrophysics Data System (ADS)

Miller, V. A.; Troutman, V. A.; Mungal, M. G.; Hanson, R. K.

2014-10-01

This manuscript describes continuous, high-repetition-rate (20 kHz) toluene planar laser-induced fluorescence (PLIF) imaging in an expansion tube impulse flow facility. Cinematographic image sequences are acquired that visualize an underexpanded jet of hydrogen in Mach 0.9 crossflow, a practical flow configuration relevant to aerospace propulsion systems. The freestream gas is nitrogen seeded with toluene; toluene broadly absorbs and fluoresces in the ultraviolet, and the relatively high quantum yield of toluene produces large signals and high signal-to-noise ratios. Toluene is excited using a commercially available, frequency-quadrupled (266 nm), high-repetition-rate (20 kHz), pulsed (0.8-0.9 mJ per pulse), diode-pumped solid-state Nd:YAG laser, and fluorescence is imaged with a high-repetition-rate intensifier and CMOS camera. The resulting PLIF movie and image sequences are presented, visualizing the jet start-up process and the dynamics of the jet in crossflow; the freestream duration and a measure of freestream momentum flux steadiness are also inferred. This work demonstrates progress toward continuous PLIF imaging of practical flow systems in impulse facilities at kHz acquisition rates using practical, turn-key, high-speed laser and imaging systems.

High-energy, high-resolution x-ray imaging for metallic cultural heritages

NASA Astrophysics Data System (ADS)

Hoshino, Masato; Uesugi, Kentaro; Shikaku, Ryuji; Yagi, Naoto

2017-10-01

An x-ray micro-imaging technique to visualize high-resolution structure of cultural heritages made of iron or copper has been developed. It utilizes high-energy x-rays from a bending magnet at the SPring-8 synchrotron radiation facility. A white x-ray beam was attenuated by 0.5 mm tungsten and 2.0 mm lead absorbers resulting in the peak energy of 200 keV. The tungsten absorber eliminated the photon energy peak below the absorption edge of lead. A sample was rotated over 180 degrees in 500 s and projection images were continuously collected with an exposure time of 500 ms by an sCMOS camera equipped with a scintillator. Tomographic reconstruction of an ancient sword containing of both copper and iron was successfully obtained at a voxel size of 14.8 μm. Beam hardening was found to cause 2.5 % differences in density in a reconstructed image of a homogeneous stainless-steel rod. Ring artefacts were reduced by continuously moving the absorbers. This work demonstrates feasibility of high-energy, high-resolution imaging at a synchrotron beamline which may be generally useful for inspecting metallic objects.

Three-Dimensional Bi-Continuous Nanoporous Gold/Nickel Foam Supported MnO2 for High Performance Supercapacitors.

PubMed

Zhao, Jie; Zou, Xilai; Sun, Peng; Cui, Guofeng

2017-12-19

A three-dimensional bi-continuous nanoporous gold (NPG)/nickel foam is developed though the electrodeposition of a gold-tin alloy on Ni foam and subsequent chemical dealloying of tin. The newly-designed 3D metal structure is used to anchor MnO 2 nanosheets for high-performance supercapacitors. The formed ternary composite electrodes exhibit significantly-enhanced capacitance performance, rate capability, and excellent cycling stability. A specific capacitance of 442 Fg -1 is achieved at a scan rate of 5 mV s -1 and a relatively high mass loading of 865 μg cm -2 . After 2500 cycles, only a 1% decay is found at a scan rate of 50 mV s -1 . A high power density of 3513 W kg -1 and an energy density of 25.73 Wh kg -1 are realized for potential energy storage devices. The results demonstrate that the NPG/nickel foam hybrid structure significantly improves the dispersibility of MnO 2 and makes it promising for practical energy storage applications.

40 CFR 63.7121 - How do I demonstrate continuous compliance with the emission limitations standard?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Pollutants for Lime Manufacturing Plants Continuous Compliance Requirements § 63.7121 How do I demonstrate... 22 of appendix A to part 60 of this chapter. (f) For existing lime kilns and their associated coolers...

5 CFR 890.1304 - Enrollment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL... Demonstration Project § 890.1304 Enrollment. (a) Open Season for eligible beneficiaries will be held concurrent... employee organization sponsored plans that are participating in the demonstration project. (c) DoD will...

40 CFR 264.272 - Treatment demonstration.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Section 264.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Land Treatment § 264.272 Treatment demonstration. (a) For each waste that will be applied to the...

40 CFR 264.272 - Treatment demonstration.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 264.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Land Treatment § 264.272 Treatment demonstration. (a) For each waste that will be applied to the...

40 CFR 264.272 - Treatment demonstration.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 264.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Land Treatment § 264.272 Treatment demonstration. (a) For each waste that will be applied to the...

40 CFR 264.272 - Treatment demonstration.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 264.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Land Treatment § 264.272 Treatment demonstration. (a) For each waste that will be applied to the...

40 CFR 264.272 - Treatment demonstration.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 264.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Land Treatment § 264.272 Treatment demonstration. (a) For each waste that will be applied to the...

Low-Temperature Wafer-Scale Deposition of Continuous 2D SnS2 Films.

PubMed

Mattinen, Miika; King, Peter J; Khriachtchev, Leonid; Meinander, Kristoffer; Gibbon, James T; Dhanak, Vin R; Räisänen, Jyrki; Ritala, Mikko; Leskelä, Markku

2018-04-19

Semiconducting 2D materials, such as SnS 2 , hold immense potential for many applications ranging from electronics to catalysis. However, deposition of few-layer SnS 2 films has remained a great challenge. Herein, continuous wafer-scale 2D SnS 2 films with accurately controlled thickness (2 to 10 monolayers) are realized by combining a new atomic layer deposition process with low-temperature (250 °C) postdeposition annealing. Uniform coating of large-area and 3D substrates is demonstrated owing to the unique self-limiting growth mechanism of atomic layer deposition. Detailed characterization confirms the 1T-type crystal structure and composition, smoothness, and continuity of the SnS 2 films. A two-stage deposition process is also introduced to improve the texture of the films. Successful deposition of continuous, high-quality SnS 2 films at low temperatures constitutes a crucial step toward various applications of 2D semiconductors. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Multistage Coupling of Laser-Wakefield Accelerators with Curved Plasma Channels.

PubMed

Luo, J; Chen, M; Wu, W Y; Weng, S M; Sheng, Z M; Schroeder, C B; Jaroszynski, D A; Esarey, E; Leemans, W P; Mori, W B; Zhang, J

2018-04-13

Multistage coupling of laser-wakefield accelerators is essential to overcome laser energy depletion for high-energy applications such as TeV-level electron-positron colliders. Current staging schemes feed subsequent laser pulses into stages using plasma mirrors while controlling electron beam focusing with plasma lenses. Here a more compact and efficient scheme is proposed to realize the simultaneous coupling of the electron beam and the laser pulse into a second stage. A partly curved channel, integrating a straight acceleration stage with a curved transition segment, is used to guide a fresh laser pulse into a subsequent straight channel, while the electrons continue straight. This scheme benefits from a shorter coupling distance and continuous guiding of the electrons in plasma while suppressing transverse beam dispersion. Particle-in-cell simulations demonstrate that the electron beam from a previous stage can be efficiently injected into a subsequent stage for further acceleration while maintaining high capture efficiency, stability, and beam quality.

Multistage Coupling of Laser-Wakefield Accelerators with Curved Plasma Channels

NASA Astrophysics Data System (ADS)

Luo, J.; Chen, M.; Wu, W. Y.; Weng, S. M.; Sheng, Z. M.; Schroeder, C. B.; Jaroszynski, D. A.; Esarey, E.; Leemans, W. P.; Mori, W. B.; Zhang, J.

2018-04-01

Multistage coupling of laser-wakefield accelerators is essential to overcome laser energy depletion for high-energy applications such as TeV-level electron-positron colliders. Current staging schemes feed subsequent laser pulses into stages using plasma mirrors while controlling electron beam focusing with plasma lenses. Here a more compact and efficient scheme is proposed to realize the simultaneous coupling of the electron beam and the laser pulse into a second stage. A partly curved channel, integrating a straight acceleration stage with a curved transition segment, is used to guide a fresh laser pulse into a subsequent straight channel, while the electrons continue straight. This scheme benefits from a shorter coupling distance and continuous guiding of the electrons in plasma while suppressing transverse beam dispersion. Particle-in-cell simulations demonstrate that the electron beam from a previous stage can be efficiently injected into a subsequent stage for further acceleration while maintaining high capture efficiency, stability, and beam quality.

Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow

NASA Astrophysics Data System (ADS)

Seo, Hyowon; Katcher, Matthew H.; Jamison, Timothy F.

2017-05-01

Although carbon dioxide (CO2) is highly abundant, its low reactivity has limited its use in chemical synthesis. In particular, methods for carbon-carbon bond formation generally rely on two-electron mechanisms for CO2 activation and require highly activated reaction partners. Alternatively, radical pathways accessed via photoredox catalysis could provide new reactivity under milder conditions. Here we demonstrate the direct coupling of CO2 and amines via the single-electron reduction of CO2 for the photoredox-catalysed continuous flow synthesis of α-amino acids. By leveraging the advantages of utilizing gases and photochemistry in flow, a commercially available organic photoredox catalyst effects the selective α-carboxylation of amines that bear various functional groups and heterocycles. The preliminary mechanistic studies support CO2 activation and carbon-carbon bond formation via single-electron pathways, and we expect that this strategy will inspire new perspectives on using this feedstock chemical in organic synthesis.

Update on the epidemiology of the rheumatic diseases.

PubMed

Gabriel, S E

1996-03-01

Epidemiologic studies continue to enhance our understanding of the rheumatic diseases. Such studies now indicate that 26 million American women are at risk for osteoporotic fractures. Contrary to previous recommendations, the identification and treatment of patients at risk for osteoporosis may be valuable even among very elderly people. Other epidemiologic studies suggest that the incidence of rheumatoid arthritis is decreasing and that it is a more benign disease than previously recognized. Osteoarthritis remains a leading cause of physical and work disability in North America. The roles of occupational physical activity, obesity, and highly competitive (though not low-impact) exercise as risk factors for osteoarthritis continue to be explored. Pharmacoepidemiologic research has recently demonstrated that a policy of prior authorization for prescription of nonsteroidal anti-inflammatory drugs may be highly cost effective. Finally, controlled epidemiologic studies have not confirmed an association between silicone breast implants and connective tissue diseases, a conclusion recently endorsed by the American College of Rheumatology.

303 nm continuous wave ultraviolet laser generated by intracavity frequency-doubling of diode-pumped Pr3+:LiYF4 laser

NASA Astrophysics Data System (ADS)

Zhu, Pengfei; Zhang, Chaomin; Zhu, Kun; Ping, Yunxia; Song, Pei; Sun, Xiaohui; Wang, Fuxin; Yao, Yi

2018-03-01

We demonstrate an efficient and compact ultraviolet laser at 303 nm generated by intracavity frequency doubling of a continuous wave (CW) laser diode-pumped Pr3+:YLiF4 laser at 607 nm. A cesium lithium borate (CLBO) crystal, cut for critical type I phase matching at room temperature, is used for second-harmonic generation (SHG) of the fundamental laser. By using an InGaN laser diode array emitting at 444.3 nm with a maximum incident power of 10 W, as high as 68 mW of CW output power at 303 nm is achieved. The output power stability in 4 h is better than 2.85%. To the best of our knowledge, this is high efficient UV laser generated by frequency doubling of an InGaN laser diode array pumped Pr3+:YLiF4 laser.

New continuous recording procedure of holographic information on transient phenomena

NASA Astrophysics Data System (ADS)

Nagayama, Kunihito; Nishihara, H. Keith; Murakami, Terutoshi

1992-09-01

A new method for continuous recording of holographic information, 'streak holography,' is proposed. This kind of record can be useful for velocity and acceleration measurement as well as for observing a moving object whose trajectory cannot be predicted in advance. A very high speed camera system has been designed and constructed for streak holography. A ring-shaped 100-mm-diam film has been cut out from the high-resolution sheet film and mounted on a thin duralmin disk, which has been driven to rotate directly by an air-turbine spindle. Attainable streak velocity is 0.3 mm/microsecond(s) . A direct film drive mechanism makes it possible to use a relay lens system of extremely small f number. The feasibility of the camera system has been demonstrated by observing several transient events, such as the forced oscillation of a wire and the free fall of small glass particles, using an argon-ion laser as a light source.

Cotton-textile-enabled flexible self-sustaining power packs via roll-to-roll fabrication

PubMed Central

Gao, Zan; Bumgardner, Clifton; Song, Ningning; Zhang, Yunya; Li, Jingjing; Li, Xiaodong

2016-01-01

With rising energy concerns, efficient energy conversion and storage devices are required to provide a sustainable, green energy supply. Solar cells hold promise as energy conversion devices due to their utilization of readily accessible solar energy; however, the output of solar cells can be non-continuous and unstable. Therefore, it is necessary to combine solar cells with compatible energy storage devices to realize a stable power supply. To this end, supercapacitors, highly efficient energy storage devices, can be integrated with solar cells to mitigate the power fluctuations. Here, we report on the development of a solar cell-supercapacitor hybrid device as a solution to this energy requirement. A high-performance, cotton-textile-enabled asymmetric supercapacitor is integrated with a flexible solar cell via a scalable roll-to-roll manufacturing approach to fabricate a self-sustaining power pack, demonstrating its potential to continuously power future electronic devices. PMID:27189776

Continuous manufacturing of extended release tablets via powder mixing and direct compression.

PubMed

Ervasti, Tuomas; Simonaho, Simo-Pekka; Ketolainen, Jarkko; Forsberg, Peter; Fransson, Magnus; Wikström, Håkan; Folestad, Staffan; Lakio, Satu; Tajarobi, Pirjo; Abrahmsén-Alami, Susanna

2015-11-10

The aim of the current work was to explore continuous dry powder mixing and direct compression for manufacturing of extended release (ER) matrix tablets. The study was span out with a challenging formulation design comprising ibuprofen compositions with varying particle size and a relatively low amount of the matrix former hydroxypropyl methylcellulose (HPMC). Standard grade HPMC (CR) was compared to a recently developed direct compressible grade (DC2). The work demonstrate that ER tablets with desired quality attributes could be manufactured via integrated continuous mixing and direct compression. The most robust tablet quality (weight, assay, tensile strength) was obtained using high mixer speed and large particle size ibuprofen and HPMC DC2 due to good powder flow. At low mixer speed it was more difficult to achieve high quality low dose tablets. Notably, with HPMC DC2 the processing conditions had a significant effect on drug release. Longer processing time and/or faster mixer speed was needed to achieve robust release with compositions containing DC2 compared with those containing CR. This work confirms the importance of balancing process parameters and material properties to find consistent product quality. Also, adaptive control is proven a pivotal means for control of continuous manufacturing systems. Copyright © 2015 Elsevier B.V. All rights reserved.

The skiers knee without swelling or instability, a difficult diagnosis: a case report

PubMed Central

O'Donnell, Mark E; Badger, Stephen A; Campbell, David; Loan, Willie; Sinnott, Brendan

2007-01-01

Skiing as a recreational activity has increased exponentially in the last twenty-years. Similar to any sporting activity, participants can sustain various types of injury, which provides the emergency departments with a continuous supply of patients. The injury pattern from the slopes has also changed over this time period, due to alterations and improvements in ski equipment. An increased diversity in alpine skiing techniques, as well as snowboarding and cross-terrain disciplines has also influenced this change. We present a multi-media experience of a high-speed ski fall that caused a valgus-external rotation injury to the right knee that precluded the patient from further ski activity. There was no bruising, swelling or instability demonstrated and the patient returned to ski activities 24-hours post-injury. Although this injury appeared clinically benign initially, the patient complained of persistent pain around the right knee which was causing occupational difficulties. Following normal clinical assessment, the patient returned to work but continued to complain of persistent pain at the lateral aspect of the right knee. Magnetic Resonance Imaging (MRI) demonstrated extensive bone marrow oedema (BMO), a mild depression of the articular cortex compression with a small focus of articular cartilage disruption and microfractures of the lateral tibial plateau. The patient was treated conservatively and remains well with avoidance of impact exercises 14-months post-injury. In the presence of any high speed injury, we would stress that regardless of initial normal investigations, clinical suspicion should remain paramount and not deter the physician from further investigation in the presence of continuing symptomatology. PMID:17448236

Continuous, Large-Scale Processing of Seismic Archives for High-Resolution Monitoring of Seismic Activity and Seismogenic Properties

NASA Astrophysics Data System (ADS)

Waldhauser, F.; Schaff, D. P.

2012-12-01

Archives of digital seismic data recorded by seismometer networks around the world have grown tremendously over the last several decades helped by the deployment of seismic stations and their continued operation within the framework of monitoring earthquake activity and verification of the Nuclear Test-Ban Treaty. We show results from our continuing effort in developing efficient waveform cross-correlation and double-difference analysis methods for the large-scale processing of regional and global seismic archives to improve existing earthquake parameter estimates, detect seismic events with magnitudes below current detection thresholds, and improve real-time monitoring procedures. We demonstrate the performance of these algorithms as applied to the 28-year long seismic archive of the Northern California Seismic Network. The tools enable the computation of periodic updates of a high-resolution earthquake catalog of currently over 500,000 earthquakes using simultaneous double-difference inversions, achieving up to three orders of magnitude resolution improvement over existing hypocenter locations. This catalog, together with associated metadata, form the underlying relational database for a real-time double-difference scheme, DDRT, which rapidly computes high-precision correlation times and hypocenter locations of new events with respect to the background archive (http://ddrt.ldeo.columbia.edu). The DDRT system facilitates near-real-time seismicity analysis, including the ability to search at an unprecedented resolution for spatio-temporal changes in seismogenic properties. In areas with continuously recording stations, we show that a detector built around a scaled cross-correlation function can lower the detection threshold by one magnitude unit compared to the STA/LTA based detector employed at the network. This leads to increased event density, which in turn pushes the resolution capability of our location algorithms. On a global scale, we are currently building the computational framework for double-difference processing the combined parametric and waveform archives of the ISC, NEIC, and IRIS with over three million recorded earthquakes worldwide. Since our methods are scalable and run on inexpensive Beowulf clusters, periodic re-analysis of such archives may thus become a routine procedure to continuously improve resolution in existing global earthquake catalogs. Results from subduction zones and aftershock sequences of recent great earthquakes demonstrate the considerable social and economic impact that high-resolution images of active faults, when available in real-time, will have in the prompt evaluation and mitigation of seismic hazards. These results also highlight the need for consistent long-term seismic monitoring and archiving of records.

High throughput two-step ultrasonic spray deposited CH3NH3PbI3 thin film layer for solar cell application

NASA Astrophysics Data System (ADS)

Lan, Ding-Hung; Hong, Shao-Huan; Chou, Li-Hui; Wang, Xiao-Feng; Liu, Cheng-Liang

2018-06-01

Organometal halide perovskite materials have demonstrated tremendous advances in the photovoltaic field recently because of their advantageous features of simple fabrication and high power conversion efficiency. To meet the high demand for high throughput and cost-effective, we present a wet process method that enables the probing of the parameters for perovskite layer deposition through two-step sequential ultrasonic spray-coating. This paper describes a detailed investigation on the effects of modification of spray precursor solution (PbI2 and CH3NH3I precursor concentration and solvents used) and post-annealing condition (temperature and time), which can be performed to create optimal film quality as well as improve device efficiency. Through the systematic optimization, the inverted planar perovskite solar cells show the reproducible photovoltaic properties with best power conversion efficiency (PCE) of 10.40% and average PCE of 9.70 ± 0.40%. A continuous spray-coating technique for rapid fabrication of total 16 pieces of perovskite films was demonstrated for providing a viable alternative for the high throughput production of the perovskite solar cells.

Fully-resonant, tunable, monolithic frequency conversion as a coherent UVA source.

PubMed

Zielińska, Joanna A; Zukauskas, Andrius; Canalias, Carlota; Noyan, Mehmet A; Mitchell, Morgan W

2017-01-23

We demonstrate a monolithic frequency converter incorporating up to four tuning degrees of freedom, three temperature and one strain, allowing resonance of pump and generated wavelengths simultaneous with optimal phase-matching. With a Rb-doped periodically-poled potassium titanyl phosphate (KTP) implementation, we demonstrate efficient continuous-wave second harmonic generation from 795 to 397, with low-power efficiency of 72% and high-power slope efficiency of 4.5%. The measured performance shows good agreement with theoretical modeling of the device. We measure optical bistability effects, and show how they can be used to improve the stability of the output against pump frequency and amplitude variations.

AN EVALUATION OF THE INTERACTION BETWEEN QUALITY OF ATTENTION AND NEGATIVE REINFORCEMENT WITH CHILDREN WHO DISPLAY ESCAPE-MAINTAINED PROBLEM BEHAVIOR

PubMed Central

Gardner, Andrew W; Wacker, David P; Boelter, Eric W

2009-01-01

The choice-making behavior of 2 typically developing children who engaged in problem behavior maintained by negative reinforcement was evaluated within a concurrent-operants assessment that varied the quality of attention across free-play and demand conditions. The results demonstrated that it was possible to bias responding towards academic demands for both participants by providing high-quality attention, despite the continuous availability of negative reinforcement. The current study extended brief clinical methods with typically developing children and demonstrated how different qualities of attention provided across concurrent schedules could bias responding. PMID:19949522

Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae

PubMed Central

Mondal, Amitabha; Venkataramaiah, Manjunath; Rajamohan, Govindan; Srinivasan, Vijaya Bharathi

2016-01-01

Nosocomial infections due to Klebsiella pneumoniae is a significant problem in health care settings worldwide. In this study, we examined the antimicrobial susceptibility, genetic profiles and mechanisms of antibiotic resistance in K. pneumoniae isolates of Indian origin. To our knowledge this is the first report demonstrating the high prevalence of β-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes besides demonstrating the involvement of active efflux in K. pneumoniae Indian isolates. This study has enabled us to correlate the phenotypic and genotypic characteristics in K. pneumoniae, providing an important base for continued monitoring and epidemiological studies of this emerging nosocomial pathogen in Indian hospitals. PMID:27870879

Performance of a newly designed continuous soot monitoring system (COSMOS).

PubMed

Miyazaki, Yuzo; Kondo, Yutaka; Sahu, Lokesh K; Imaru, Junichi; Fukushima, Nobuhiko; Kano, Minoru

2008-10-01

We designed a continuous soot monitoring system (COSMOS) for fully automated, high-sensitivity, continuous measurement of light absorption by black carbon (BC) aerosols. The instrument monitors changes in transmittance across an automatically advancing quartz fiber filter tape using an LED at a 565 nm wavelength. To achieve measurements with high sensitivity and a lower detectable light absorption coefficient, COSMOS uses a double-convex lens and optical bundle pipes to maintain high light intensity and signal data are obtained at 1000 Hz. In addition, sampling flow rate and optical unit temperature are actively controlled. The inlet line for COSMOS is heated to 400 degrees C to effectively volatilize non-refractory aerosol components that are internally mixed with BC. In its current form, COSMOS provides BC light absorption measurements with a detection limit of 0.45 Mm(-1) (0.045 microg m(-3) for soot) for 10 min. The unit-to-unit variability is estimated to be within +/- 1%, demonstrating its high reproducibility. The absorption coefficients determined by COSMOS agreed with those by a particle soot absorption photometer (PSAP) to within 1% (r2 = 0.97). The precision (+/- 0.60 Mm(-1)) for 10 min integrated data was better than that of PSAP and an aethalometer under our operating conditions. These results showed that COSMOS achieved both an improved detection limit and higher precision for the filter-based light absorption measurements of BC compared to the existing methods.

Distributed Learning, Extremum Seeking, and Model-Free Optimization for the Resilient Coordination of Multi-Agent Adversarial Groups

DTIC Science & Technology

2016-09-07

been demonstrated on maximum power point tracking for photovoltaic arrays and for wind turbines . 3. ES has recently been implemented on the Mars...high-dimensional optimization problems . Extensions and applications of these techniques were developed during the realization of the project. 15...studied problems of dynamic average consensus and a class of unconstrained continuous-time optimization algorithms for the coordination of multiple

Large energy laser pulses with high repetition rate by graphene Q-switched solid-state laser.

PubMed

Li, Xian-lei; Xu, Jin-long; Wu, Yong-zhong; He, Jing-liang; Hao, Xiao-peng

2011-05-09

We demonstrated that the graphene could be used as an effective saturable absorber for Q-switched solid-state lasers. A graphene saturable absorber mirror was fabricated with large and high-quality graphene sheets deprived from the liquid phase exfoliation. Using this mirror, 105-ns pulses and 2.3-W average output power are obtained from a passively Q-switched Nd:GdVO(4) laser. The maximum pulse energy is 3.2 μJ. The slope efficiency is as high as 37% approximating to 40% of the continue-wave laser, indicating a low intrinsic loss of the graphene. © 2011 Optical Society of America

Hermetic encapsulation technique for solar arrays

NASA Technical Reports Server (NTRS)

Deminet, C.; Horne, W. E.

1980-01-01

A concept is presented for encapsulating solar cells between two layers of glass either individually, in panels, or in a continuous process. The concept yields an integral unit that is hermetically sealed and that is tolerant to high temperature thermal cycling and to particulate radiation. Data are presented on both high temperature solar cells and special glasses that soften at low temperatures for use with the concept. The results of encapsulating experiments are presented which show the successful application of the concept to the special high temperature cells. The mechanical feasibility of encapsulating 2 mil cells between two layers of 2 mil glass is also demonstrated.

Non-Linear System Identification for Aeroelastic Systems with Application to Experimental Data

NASA Technical Reports Server (NTRS)

Kukreja, Sunil L.

2008-01-01

Representation and identification of a non-linear aeroelastic pitch-plunge system as a model of the NARMAX class is considered. A non-linear difference equation describing this aircraft model is derived theoretically and shown to be of the NARMAX form. Identification methods for NARMAX models are applied to aeroelastic dynamics and its properties demonstrated via continuous-time simulations of experimental conditions. Simulation results show that (i) the outputs of the NARMAX model match closely those generated using continuous-time methods and (ii) NARMAX identification methods applied to aeroelastic dynamics provide accurate discrete-time parameter estimates. Application of NARMAX identification to experimental pitch-plunge dynamics data gives a high percent fit for cross-validated data.

15 ps quasi-continuously pumped passively mode-locked highly doped Nd:YAG laser in bounce geometry

NASA Astrophysics Data System (ADS)

Jelínek, M., Jr.; Kubeček, V.

2011-09-01

A semiconductor saturable absorber mirror mode-locking of a quasi-continuously pumped laser based on 2.4 at.% Nd:YAG slab in a bounce geometry was demonstrated and investigated. Output mode-locked and Q-switched train containing 15 pulses with total energy of 500 μJ was generated directly from the oscillator. The measured 15 ps pulse duration and excellent temporal stability ±2 ps are the best values for pure passively mode-locked and Q-switched Nd:YAG laser with the pulse pumping. Furthermore, using the cavity dumping technique, single 19 ps pulse with energy of 25 μJ was extracted directly from the oscillator.

Multi-KW dc distribution system technology research study

NASA Technical Reports Server (NTRS)

Dawson, S. G.

1978-01-01

The Multi-KW DC Distribution System Technology Research Study is the third phase of the NASA/MSFC study program. The purpose of this contract was to complete the design of the integrated technology test facility, provide test planning, support test operations and evaluate test results. The subjet of this study is a continuation of this contract. The purpose of this continuation is to study and analyze high voltage system safety, to determine optimum voltage levels versus power, to identify power distribution system components which require development for higher voltage systems and finally to determine what modifications must be made to the Power Distribution System Simulator (PDSS) to demonstrate 300 Vdc distribution capability.

Continuous-wave Nd:GYSGG laser at 1.1 μm

NASA Astrophysics Data System (ADS)

Lin, Hongyi; Liu, Hong; Huang, Xiaohua; Copner, Nigel; Sun, Dong

2018-02-01

We demonstrated a compact and simple continuous-wave (CW) Nd:GYSGG laser with triple-wavelength lines at 1105, 1107 and 1110 nm based on R2 → Y6, R1 → Y5 and R1 → Y6 of the 4F3/2 → 4I11/2 transition. The total output power of the triple-wavelength lines was 480 mW. Moreover, we obtained an efficient CW Nd:GYSGG laser at 1110 nm with the output power of 1560 mW at the pump power of 11.05 W. Those lines at 1058 and 1062 nm were suppressed completely by the simple output mirror of high transmission at 1.06 μm.

Pulsed EMAT (Electromagnetic Acoustic Transducer) acoustic measurements on a horizontal continuous caster for internal temperature determination

NASA Astrophysics Data System (ADS)

Boyd, Donald M.

1989-10-01

Development of a Pulsed Electromagnetic Acoustic Transducer (EMAT) through transmission system for acoustic measurements on steel billets up to 1300 C was completed. Laboratory measurements of acoustic velocity were made, and used to determine the average internal temperature of hot stainless and carbon steel billets. Following the success of the laboratory system development, the laboratory EMAT system was subsequently tested successfully at the Baltimore Specialty Steel Co. on a horizontal continuous caster. Details of the sensor system development and the steel plant demonstration results are presented. Future directions for the high temperature pulsed EMAT internal temperature concept are discussed for potential material processing applications.

Efficient Q-switched Tm:YAG ceramic slab laser.

PubMed

Zhang, Shuaiyi; Wang, Mingjian; Xu, Lin; Wang, Yan; Tang, Yulong; Cheng, Xiaojin; Chen, Weibiao; Xu, Jianqiu; Jiang, Benxue; Pan, Yubai

2011-01-17

Characteristics of Tm:YAG ceramic for high efficient 2-μm lasers are analyzed. Efficient diode end-pumped continuous-wave and Q-switched Tm:YAG ceramic lasers are demonstrated. At the absorbed pump power of 53.2W, the maximum continuous wave (cw) output power of 17.2 W around 2016 nm was obtained with the output transmission of 5%. The optical conversion efficiency is 32.3%, corresponding to a slope efficiency of 36.5%. For Q-switched operation, the shortest width of 69 ns was achieved with the pulse repetition frequency of 500 Hz and single pulse energy of 20.4 mJ, which indicates excellent energy storage capability of the Tm:YAG ceramic.

5 CFR 890.1302 - Duration.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Duration. 890.1302 Section 890.1302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL... Demonstration Project § 890.1302 Duration. The demonstration project will run from January 1, 2000, through...

40 CFR 270.65 - Research, development, and demonstration permits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) SOLID WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM... may issue a research, development, and demonstration permit for any hazardous waste treatment facility which proposes to utilize an innovative and experimental hazardous waste treatment technology or process...

40 CFR 270.65 - Research, development, and demonstration permits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) SOLID WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM... may issue a research, development, and demonstration permit for any hazardous waste treatment facility which proposes to utilize an innovative and experimental hazardous waste treatment technology or process...

Contact acoustic nonlinearity (CAN)-based continuous monitoring of bolt loosening: Hybrid use of high-order harmonics and spectral sidebands

NASA Astrophysics Data System (ADS)

Zhang, Zhen; Liu, Menglong; Liao, Yaozhong; Su, Zhongqing; Xiao, Yi

2018-03-01

The significance of evaluating bolt tightness in engineering structures, preferably in a continuous manner, cannot be overemphasized. With hybrid use of high-order harmonics (HOH) and spectral sidebands, a contact acoustic nonlinearity (CAN)-based monitoring framework is developed for detecting bolt loosening and subsequently evaluating the residual torque on a loose bolt. Low-frequency pumping vibration is introduced into the bolted joint to produce a "breathing" effect at the joining interface that modulates the propagation characteristics of a high-frequency probing wave when it traverses the bolt, leading to the generation of HOH and vibro-acoustic nonlinear distortions (manifested as sidebands in the signal spectrum). To gain insight into the mechanism of CAN generation and to correlate the acquired nonlinear responses of a loose joint with the residual torque remaining on the bolt, an analytical model based on micro-contact theory is established. Two types of nonlinear index, respectively exploiting the induced HOH and spectral sidebands, are defined without dependence on excitation intensity and are experimentally demonstrated to be effective in continuously monitoring bolt loosening in both aluminum-aluminum and composite-composite bolted joints. Taking a step further, variation of the index pair is quantitatively associated with the residual torque on a loose bolt. The approach developed provides a reliable method of continuous evaluation of bolt tightness in both composite and metallic joints, regardless of their working conditions, from early awareness of bolt loosening at an embryonic stage to quantitative estimation of residual torque.

Tunable multipole resonances in plasmonic crystals made by four-beam holographic lithography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, Y.; Li, X.; Zhang, X.

2016-02-01

Plasmonic nanostructures confine light to sub-wavelength scales, resulting in drastically enhanced light-matter interactions. Recent interest has focused on controlled symmetry breaking to create higher-order multipole plasmonic modes that store electromagnetic energy more efficiently than dipole modes. Here we demonstrate that four-beam holographic lithography enables fabrication of large-area plasmonic crystals with near-field coupled plasmons as well as deliberately broken symmetry to sustain multipole modes and Fano-resonances. Compared with the spectrally broad dipole modes we demonstrate an order of magnitude improved Q-factors (Q = 21) when the quadrupole mode is activated. We further demonstrate continuous tuning of the Fano-resonances using the polarization state ofmore » the incident light beam. The demonstrated technique opens possibilities to extend the rich physics of multipole plasmonic modes to wafer-scale applications that demand low-cost and high-throughput.« less

High-intensity interval training has positive effects on performance in ice hockey players.

PubMed

Naimo, M A; de Souza, E O; Wilson, J M; Carpenter, A L; Gilchrist, P; Lowery, R P; Averbuch, B; White, T M; Joy, J

2015-01-01

In spite of the well-known benefits that have been shown, few studies have looked at the practical applications of high-intensity interval training (HIIT) on athletic performance. This study investigated the effects of a HIIT program compared to traditional continuous endurance exercise training. 24 hockey players were randomly assigned to either a continuous or high-intensity interval group during a 4-week training program. The interval group (IG) was involved in a periodized HIIT program. The continuous group (CG) performed moderate intensity cycling for 45-60 min at an intensity that was 65% of their calculated heart rate reserve. Body composition, muscle thickness, anaerobic power, and on-ice measures were assessed pre- and post-training. Muscle thickness was significantly greater in IG (p=0.01) when compared to CG. The IG had greater values for both ∆ peak power (p<0.003) and ∆ mean power (p<0.02). Additionally, IG demonstrated a faster ∆ sprint (p<0.02) and a trend (p=0.08) for faster ∆ endurance test time to completion for IG. These results indicate that hockey players may utilize short-term HIIT to elicit positive effects in muscle thickness, power and on-ice performance. © Georg Thieme Verlag KG Stuttgart · New York.

Single step high-speed printing of continuous silver lines by laser-induced forward transfer

NASA Astrophysics Data System (ADS)

Puerto, D.; Biver, E.; Alloncle, A.-P.; Delaporte, Ph.

2016-06-01

The development of high-speed ink printing process by Laser-Induced Forward Transfer (LIFT) is of great interest for the printing community. To address the problems and the limitations of this process that have been previously identified, we have performed an experimental study on laser micro-printing of silver nanoparticle inks by LIFT and demonstrated for the first time the printing of continuous conductive lines in a single pass at velocities of 17 m/s using a 1 MHz repetition rate laser. We investigated the printing process by means of a time-resolved imaging technique to visualize the ejection dynamics of single and adjacent jets. The control of the donor film properties is of prime importance to achieve single step printing of continuous lines at high velocities. We use a 30 ps pulse duration laser with a wavelength of 343 nm and a repetition rate from 0.2 to 1 MHz. A galvanometric mirror head controls the distance between two consecutives jets by scanning the focused beam along an ink-coated donor substrate at different velocities. Droplets and lines of silver inks are laser-printed on glass and PET flexible substrates and we characterized their morphological quality by atomic force microscope (AFM) and optical microscope.

Reduced-Pressure Chemical Vapor Deposition Growth of Isolated Ge Crystals and Suspended Layers on Micrometric Si Pillars.

PubMed

Skibitzki, Oliver; Capellini, Giovanni; Yamamoto, Yuji; Zaumseil, Peter; Schubert, Markus Andreas; Schroeder, Thomas; Ballabio, Andrea; Bergamaschini, Roberto; Salvalaglio, Marco; Miglio, Leo; Montalenti, Francesco

2016-10-05

In this work, we demonstrate the growth of Ge crystals and suspended continuous layers on Si(001) substrates deeply patterned in high aspect-ratio pillars. The material deposition was carried out in a commercial reduced-pressure chemical vapor deposition reactor, thus extending the "vertical-heteroepitaxy" technique developed by using the peculiar low-energy plasma-enhanced chemical vapor deposition reactor, to widely available epitaxial tools. The growth process was thoroughly analyzed, from the formation of small initial seeds to the final coalescence into a continuous suspended layer, by means of scanning and transmission electron microscopy, X-ray diffraction, and μ-Raman spectroscopy. The preoxidation of the Si pillar sidewalls and the addition of hydrochloric gas in the reactants proved to be key to achieve highly selective Ge growth on the pillars top only, which, in turn, is needed to promote the formation of a continuous Ge layer. Thanks to continuum growth models, we were able to single out the different roles played by thermodynamics and kinetics in the deposition dynamics. We believe that our findings will open the way to the low-cost realization of tens of micrometers thick heteroepitaxial layer (e.g., Ge, SiC, and GaAs) on Si having high crystal quality.

CRADA Final Report For CRADA NO. CR-12-006 [Operation and Testing of an SO 2-depolarized Electrolyzer (SDE) for the Purpose of Hydrogen and Sulfuric Acid Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Summers, W. A.; Colon-Mercado, H. R.; Steimke, J. L.

2014-02-24

Over the past several years, Savannah River National Laboratory (SRNL) has led a team of collaborators under the Department of Energy’s (DOE) nuclear hydrogen production program to develop the Hybrid Sulfur (HyS) Process. HyS is a 2-step water-splitting process consisting of high temperature decomposition of sulfuric acid to generate SO 2, followed by the electrolysis of aqueous SO 2 to generate hydrogen and sulfuric acid. The latter is fed back into the high temperature reactor. SRNL designed and built an SO 2-depolarized electrolyzer (SDE) and a test facility. Over 40 SDE’s were tested using different catalysts, membranes and other components.more » SRNL demonstrated that an SDE could be operated continuously for approximately 200 hours under certain conditions without buildup of sulfur at the SDE’s cathode, thus solving a key technical problem with SDE technology. Air Products and Chemicals, Inc. (APCI) is a major supplier of hydrogen production systems, and they have proprietary technology that could benefit from the SDE developed by SRNS, or some improved version thereof. However, to demonstrate that SRNL’s SDE is a truly viable approach to the electrolyzer design, continuous operation for far greater periods of time than 200 hours must be demonstrated, and the electrolyzer must be scaled up to greater hydrogen production capacities. SRNL and Air Products entered into a Cooperative Research and Development Agreement with the objective of demonstrating the effectiveness of the SDE for hydrogen and sulfuric acid production and to demonstrate long-term continuous operation so as to dramatically increase the confidence in the SDE design for commercial operation. SRNL prepared a detailed technical report documenting previous SDE development, including the current SDE design and operating conditions that led to the 200-hour sulfurfree testing. SRNL refurbished its single cell SDE test facility and qualified the equipment for continuous operation. A new membrane electrode assembly (MEA) was fabricated and installed in the single cell electrolyzer (60 cm 2 active cell area). Shakedown testing was conducted, and several modifications were made to the test facility equipment. Seven different MEAs were used during testing. Beginning on May 20, 2013, SRNL was able to test the SDE continuously for 1200 hours, including 1000 hours under power to generate hydrogen at an average rate of 10.8 liters per hour. The SDE was not removed or repaired during the 50-day test and was successfully restarted after each shutdown. The test was intentionally stopped after 1200 hours (1000 hours of hydrogen production) due to funding constraints. Post-test examination of the MEA using Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Microanalysis (EDAX) showed no elemental sulfur deposits or sulfur layer inside the cell, thus successfully achieving the test goals. The results demonstrated that the SDE could be operated for extended periods without major performance degradation or the buildup of sulfur inside the MEA. Air Products conducted an assessment of the economic viability of the SDE based on the “as tested” design. The results indicated that the SDE faces significant economic obstacles in its current state. Further development and scale-up are necessary before the SDE is ready for commercialization.« less

A Segway RMP-based robotic transport system

NASA Astrophysics Data System (ADS)

Nguyen, Hoa G.; Kogut, Greg; Barua, Ripan; Burmeister, Aaron; Pezeshkian, Narek; Powell, Darren; Farrington, Nathan; Wimmer, Matt; Cicchetto, Brett; Heng, Chana; Ramirez, Velia

2004-12-01

In the area of logistics, there currently is a capability gap between the one-ton Army robotic Multifunction Utility/Logistics and Equipment (MULE) vehicle and a soldier"s backpack. The Unmanned Systems Branch at Space and Naval Warfare Systems Center (SPAWAR Systems Center, or SSC), San Diego, with the assistance of a group of interns from nearby High Tech High School, has demonstrated enabling technologies for a solution that fills this gap. A small robotic transport system has been developed based on the Segway Robotic Mobility Platform (RMP). We have demonstrated teleoperated control of this robotic transport system, and conducted two demonstrations of autonomous behaviors. Both demonstrations involved a robotic transporter following a human leader. In the first demonstration, the transporter used a vision system running a continuously adaptive mean-shift filter to track and follow a human. In the second demonstration, the separation between leader and follower was significantly increased using Global Positioning System (GPS) information. The track of the human leader, with a GPS unit in his backpack, was sent wirelessly to the transporter, also equipped with a GPS unit. The robotic transporter traced the path of the human leader by following these GPS breadcrumbs. We have additionally demonstrated a robotic medical patient transport capability by using the Segway RMP to power a mock-up of the Life Support for Trauma and Transport (LSTAT) patient care platform, on a standard NATO litter carrier. This paper describes the development of our demonstration robotic transport system and the various experiments conducted.

High Speed Operation and Testing of a Fault Tolerant Magnetic Bearing

NASA Technical Reports Server (NTRS)

DeWitt, Kenneth; Clark, Daniel

2004-01-01

Research activities undertaken to upgrade the fault-tolerant facility, continue testing high-speed fault-tolerant operation, and assist in the commission of the high temperature (1000 degrees F) thrust magnetic bearing as described. The fault-tolerant magnetic bearing test facility was upgraded to operate to 40,000 RPM. The necessary upgrades included new state-of-the art position sensors with high frequency modulation and new power edge filtering of amplifier outputs. A comparison study of the new sensors and the previous system was done as well as a noise assessment of the sensor-to-controller signals. Also a comparison study of power edge filtering for amplifier-to-actuator signals was done; this information is valuable for all position sensing and motor actuation applications. After these facility upgrades were completed, the rig is believed to have capabilities for 40,000 RPM operation, though this has yet to be demonstrated. Other upgrades included verification and upgrading of safety shielding, and upgrading control algorithms. The rig will now also be used to demonstrate motoring capabilities and control algorithms are in the process of being created. Recently an extreme temperature thrust magnetic bearing was designed from the ground up. The thrust bearing was designed to fit within the existing high temperature facility. The retrofit began near the end of the summer, 04, and continues currently. Contract staff authored a NASA-TM entitled "An Overview of Magnetic Bearing Technology for Gas Turbine Engines", containing a compilation of bearing data as it pertains to operation in the regime of the gas turbine engine and a presentation of how magnetic bearings can become a viable candidate for use in future engine technology.

Provision of cellular blood components to CMV-seronegative patients undergoing allogeneic stem cell transplantation in the UK: survey of UK transplant centres.

PubMed

Morton, S; Peniket, A; Malladi, R; Murphy, M F

2017-12-01

To identify current UK practice with regards to provision of blood components for cytomegalovirus (CMV)-seronegative, potential, allogeneic stem cell recipients of seronegative grafts. Infection with CMV remains a major cause of morbidity and mortality after allogeneic stem cell transplantation (aSCT). CMV transmission has been a risk associated with the transfusion of blood components from previously exposed donors, but leucocyte reduction has been demonstrated to minimise this risk. In 2012, the UK Advisory Committee for the Safety of Tissues and Organs (SaBTO) recommended that CMV-unselected components could be safely transfused without increased risk of CMV transmission. We surveyed UK aSCT centres to establish current practice. Fifteen adult and seven paediatric centres (75%) responded; 22·7% continue to provide components from CMV-seronegative donors. Reasons cited include the continued perceived risk of CMV transmission by blood transfusion, its associated morbidity and concerns regarding potential for ambiguous CMV serostatus in seronegative potential transplant recipients due to passive antibody transfer from CMV-seropositive blood donors, leading to erroneous donor/recipient CMV matching at transplant. The survey demonstrated a surprisingly high rate (22.7%) of centres continuing to provide blood components from CMV-seronegative donors despite SaBTO guidance. © 2017 British Blood Transfusion Society.

Energy efficiency of batch and semi-batch (CCRO) reverse osmosis desalination.

PubMed

Warsinger, David M; Tow, Emily W; Nayar, Kishor G; Maswadeh, Laith A; Lienhard V, John H

2016-12-01

As reverse osmosis (RO) desalination capacity increases worldwide, the need to reduce its specific energy consumption becomes more urgent. In addition to the incremental changes attainable with improved components such as membranes and pumps, more significant reduction of energy consumption can be achieved through time-varying RO processes including semi-batch processes such as closed-circuit reverse osmosis (CCRO) and fully-batch processes that have not yet been commercialized or modelled in detail. In this study, numerical models of the energy consumption of batch RO (BRO), CCRO, and the standard continuous RO process are detailed. Two new energy-efficient configurations of batch RO are analyzed. Batch systems use significantly less energy than continuous RO over a wide range of recovery ratios and source water salinities. Relative to continuous RO, models predict that CCRO and batch RO demonstrate up to 37% and 64% energy savings, respectively, for brackish water desalination at high water recovery. For batch RO and CCRO, the primary reductions in energy use stem from atmospheric pressure brine discharge and reduced streamwise variation in driving pressure. Fully-batch systems further reduce energy consumption by not mixing streams of different concentrations, which CCRO does. These results demonstrate that time-varying processes can significantly raise RO energy efficiency. Copyright © 2016 Elsevier Ltd. All rights reserved.

Opportunities to improve the conversion of food waste to lactate: Fine-tuning secondary factors.

PubMed

RedCorn, Raymond; Engelberth, Abigail S

2017-11-01

Extensive research has demonstrated the potential for bioconversion of food waste to lactate, with major emphasis on adjusting temperature, pH, and loading rate of the fermentation. Each of these factors has a significant effect on lactate production; however, additional secondary factors have received little attention. Here we investigate three additional factors where opportunities exist for process improvement: freezing of samples during storage, discontinuous pH control, and holdover of fermentation broth between fermentations. Freezing samples prior to fermentation was shown to reduce the production rate of lactate by 8%, indicating freeze-thaw should be avoided in experiments. Prior work indicated a trade-off in pH control strategies, where discontinuous pH control correlated with higher lactate accumulation while continuous pH control correlated with higher production rate. Here we demonstrate that continuous pH control can achieve both higher lactate accumulation and higher production rate. Finally, holding over fermentation broth was shown to be a simple method to improve production rate (by 18%) at high food waste loading rates (>140 g volatile solids L -1 ) but resulted in lower lactate accumulation (by 17%). The results inform continued process improvements within the waste treatment of food waste through fermentation to lactic acid.

Optical Fiber Design And Fabrication: Discussion On Recent Developments

NASA Astrophysics Data System (ADS)

Roy, Philippe; Devautour, Mathieu; Lavoute, Laure; Gaponov, Dmitry; Brasse, Gurvan; Hautreux, Stéphanie; Février, Sébastien; Restoin, Christine; Auguste, Jean-Louis; Gérôme, Frédéric; Humbert, Georges; Blondy, Jean-Marc

2008-10-01

Level of emitted power and beam quality of singlemode fiber lasers have been drastically increased at the expense of loss due to bend sensitivity, simplicity of manufacturing and packaging. Furthermore, the extension of the spectral coverage was primarily explored by exploiting non-linear effects, neglecting numerous possible transitions of rare earths. Through different research areas, we demonstrate the possibilities offered by new fiber designs and alternative methods of manufacturing. Photonic Band Gap fibers reconcile diffraction limited beam and large mode area with low bending loss. 80% slope efficiency is demonstrated together with a robust propagation allowing the fiber to be tightly bent until wounding radii as small as 6 cm. Highly ytterbium doped multimode core surrounded by high refractive index rods fiber exhibits a transverse singlemode behavior under continuous wave laser regime. A robust LP01 mode is observed and filtering effect is clearly observed. A non CVD process based on silica sand vitrification allows the synthesis of large and highly doped core with high index homogeneity, opening the way to design of efficient large mode area fiber lasers. 74% slope efficiency is measured, demonstrating the good quality of the core material. Finally, the use of rare earth (Er3+) doped zirconia nanocrystals in silica matrix offers a large panel of ignored energy transitions for visible or off-usual band of emission.

Lithographically patterned thin activated carbon films as a new technology platform for on-chip devices.

PubMed

Wei, Lu; Nitta, Naoki; Yushin, Gleb

2013-08-27

Continuous, smooth, visibly defect-free, lithographically patterned activated carbon films (ACFs) are prepared on the surface of silicon wafers. Depending on the synthesis conditions, porous ACFs can either remain attached to the initial substrate or be separated and transferred to another dense or porous substrate of interest. Tuning the activation conditions allows one to change the surface area and porosity of the produced carbon films. Here we utilize the developed thin ACF technology to produce prototypes of functional electrical double-layer capacitor devices. The synthesized thin carbon film electrodes demonstrated very high capacitance in excess of 510 F g(-1) (>390 F cm(-3)) at a slow cyclic voltammetry scan rate of 1 mV s(-1) and in excess of 325 F g(-1) (>250 F cm(-3)) in charge-discharge tests at an ultrahigh current density of 45,000 mA g(-1). Good stability was demonstrated after 10,000 galvanostatic charge-discharge cycles. The high values of the specific and volumetric capacitances of the selected ACF electrodes as well as the capacity retention at high current densities demonstrated great potential of the proposed technology for the fabrication of various on-chip devices, such as micro-electrochemical capacitors.

Watt-Level Continuous-Wave Emission from a Bifunctional Quantum Cascade Laser/Detector

PubMed Central

2017-01-01

Bifunctional active regions, capable of light generation and detection at the same wavelength, allow a straightforward realization of the integrated mid-infrared photonics for sensing applications. Here, we present a high performance bifunctional device for 8 μm capable of 1 W single facet continuous wave emission at 15 °C. Apart from the general performance benefits, this enables sensing techniques which rely on continuous wave operation, for example, heterodyne detection, to be realized within a monolithic platform and demonstrates that bifunctional operation can be realized at longer wavelength, where wavelength matching becomes increasingly difficult and that the price to be paid in terms of performance is negligible. In laser operation, the device has the same or higher efficiency compared to the best lattice-matched QCLs without same wavelength detection capability, which is only 30% below the record achieved with strained material at this wavelength. PMID:28540324

Continuous metabolic and cardiovascular measurements on a monkey subject during a simulated 6-day Spacelab mission

NASA Technical Reports Server (NTRS)

Pace, N.; Rahlmann, D. F.; Mains, R. C.; Kodama, A. M.; Mccutcheon, E. P.

1979-01-01

A 10-kg male pig-tailed monkey (Macaca nemestrina) was selected as an optimal species for spaceflight studies on weightlessness. Three days before the simulated launch, the animal was placed in a fiberglass pod system to provide continuous measurement of respiratory gas exchange. Attention is given to examining the effects of weightlessness on several basic parameters of metabolic and cardiovascular function in an adult nonhuman primate. The 10.7-day total simulated-experiment period consisted of preflight 2.6 days, inflight 6.3 days, and postflight 1.8 days. Statistically significant diurnal variation was noted in oxygen consumption and CO2 production rates, body temperature and HR, but not in respiratory quotient or blood pressure. The high quality of the continuous data obtained demonstrates the feasibility of performing sound physiological experimentation on nonhuman primates in the Spacelab environment.

Continuous development precludes radioprotection in a colonial ascidian.

PubMed

Laird, Diana J; Weissman, Irving L

2004-03-01

Colonial organisms provide a unique experimental system for stem cell biology. The colonial Urochordate Botryllus schlosseri reproduces sexually as well as by continuous asexual budding. Adjacent colonies with a shared histocompatibility allele undergo vascular fusion and establish a common blood circulation, performing natural transplantation. Fused colonies become chimeras, often with complete somatic replacement of the host cell genotype by the fused parabiont. We attempted to establish a radioprotection assay for the somatic stem cells that induce long-term chimerism in Botryllus. We demonstrate over a range of radiation doses that neither autologous nor allogeneic cell transplantation enhances survival of host colonies. This suggests that high mitotic index associated with continuous asexual development leads to radiosensitivity of organs and structures essential to survival during engraftment. We observe that radiation induces uncontrolled epithelial cell proliferation in abnormally terminated buds, suggesting that stem cells are not required for the initial stages of bud development.

All-Systolic Non-ECG-gated Myocardial Perfusion MRI: Feasibility of Multi-Slice Continuous First-Pass Imaging

PubMed Central

Sharif, Behzad; Arsanjani, Reza; Dharmakumar, Rohan; Bairey Merz, C. Noel; Berman, Daniel S.; Li, Debiao

2015-01-01

Purpose To develop and test the feasibility of a new method for non-ECG-gated first-pass perfusion (FPP) cardiac MR capable of imaging multiple short-axis slices at the same systolic cardiac phase. Methods A magnetization-driven pulse sequence was developed for non-ECG-gated FPP imaging without saturation-recovery preparation using continuous slice-interleaved radial sampling. The image reconstruction method, dubbed TRACE, employed self-gating based on reconstruction of a real-time image-based navigator combined with reference-constrained compressed sensing. Data from ischemic animal studies (n=5) was used in a simulation framework to evaluate temporal fidelity. Healthy subjects (n=5) were studied using both the proposed and conventional method to compare the myocardial contrast-to-noise ratio (CNR). Patients (n=2) underwent adenosine stress studies using the proposed method. Results Temporal fidelity of the developed method was shown to be sufficient at high heart-rates. The healthy volunteers studies demonstrated normal perfusion and no artifacts. Compared to the conventional scheme, myocardial CNR for the proposed method was slightly higher (8.6±0.6 vs. 8.0±0.7). Patient studies showed stress-induced perfusion defects consistent with invasive angiography. Conclusions The presented methods and results demonstrate feasibility of the proposed approach for high-resolution non-ECG-gated FPP imaging and indicate its potential for achieving desirable image quality (high CNR, no dark-rim artifacts) with a 3-slice spatial coverage, all imaged at the same systolic phase. PMID:26052843

Integrated phased array for wide-angle beam steering.

PubMed

Yaacobi, Ami; Sun, Jie; Moresco, Michele; Leake, Gerald; Coolbaugh, Douglas; Watts, Michael R

2014-08-01

We demonstrate an on-chip optical phased array fabricated in a CMOS compatible process with continuous, fast (100 kHz), wide-angle (51°) beam-steering suitable for applications such as low-cost LIDAR systems. The device demonstrates the largest (51°) beam-steering and beam-spacing to date while providing the ability to steer continuously over the entire range. Continuous steering is enabled by a cascaded phase shifting architecture utilizing, low power and small footprint, thermo-optic phase shifters. We demonstrate these results in the telecom C-band, but the same design can easily be adjusted for any wavelength between 1.2 and 3.5 μm.

40 CFR 63.3161 - How do I demonstrate initial compliance?

Code of Federal Regulations, 2013 CFR

2013-07-01

... PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants: Surface Coating of Automobiles and... No. OAR-2002-0093 and Docket ID No. A-2001-22) in making this demonstration. (e) Determine the mass...

Orbital construction demonstration study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1977-01-01

A conceptual design and program plan for an Orbital Construction Demonstration Article (OCDA), that can be used for technology growth and verification, and as the construction facility for a variety of large structures is presented. The OCDA design includes a large work platform, a rotating manipulator boom, a 250 kw solar array, and a core module of subsystems with a total mass of 37,093 kg, that can be assembled in three shuttle flights. An analysis of OCDA continued utility potential indicates that a shuttle tended platform with 250 kW of power can effectively be used to construct highly beneficial antenna systems and large demonstration articles that advance solar power satellite technologies. The construction of 100 m parabolic reflectors for use as a radiometer for measuring soil moisture and water salinity was found to be within the capabilities of OCDA concept. With 252 fixed beams for high population centers, and 16 scanning beams for rural areas, the antenna has the potential to significantly improve U.S. space based communications systems. The OCDA, that is slightly increased in size, was found adequate to build a large 2 MW solar array which, when coupled to a transmit antenna, demonstrate power transfer from space to ground.

U.S. Army PEM fuel cell programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patil, A.S.; Jacobs, R.

The United States Army has identified the need for lightweight power sources to provide the individual soldier with continuous power for extended periods without resupply. Due to the high cost of primary batteries and the high weight of rechargeable batteries, fuel cell technology is being developed to provide a power source for the individual soldier, sensors, communications equipment and other various applications in the Army. Current programs are in the tech base area and will demonstrate Proton Exchange Membrane (PEM) Fuel Cell Power Sources with low weight and high energy densities. Fuel Cell Power Sources underwent user evaluations in 1996more » that showed a power source weight reduction of 75%. The quiet operation along with the ability to refuel much like an engine was well accepted by the user and numerous applications were investigated. These programs are now aimed at further weight reduction for applications that are weight critical; system integration that will demonstrate a viable military power source; refining the user requirements; and planning for a transition to engineering development.« less

ICF Annual Report 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Correll, D

The continuing objective of Lawrence Livermore National Laboratory's (LLNL's) Inertial Confinement Fusion (ICF) Program is the demonstration of thermonuclear fusion ignition and energy gain in the laboratory and to support the nuclear weapons program in its use of ICF facilities. The underlying theme of all ICF activities as a science research and development program is the Department of Energy's (DOE's) Defense Programs (DP) science-based Stockpile Stewardship Program (SSP). The mission of the US Inertial Fusion Program is twofold: (1) to address high-energy-density physics issues for the SSP and (2) to develop a laboratory microfusion capability for defense and energy applications.more » In pursuit of this mission, the ICF Program has developed a state-of-the-art capability to investigate high-energy-density physics in the laboratory. The near-term goals pursued by the ICF Program in support of its mission are demonstrating fusion ignition in the laboratory and expanding the Program's capabilities in high-energy-density science. The National Ignition Facility (NIF) project is a cornerstone of this effort.« less

A Complex Permittivity Based Sensor for the Electrical Characterization of High-Voltage Transformer Oils

PubMed Central

Dervos, Constantine T.; Paraskevas, Christos D.; Skafidas, Panayotis D.; Vassiliou, Panayota

2005-01-01

This work investigates the use of a specially designed cylindrical metal cell, in order to obtain complex permittivity and tanδ data of highly insulating High Voltage (HV) transformer oil samples. The data are obtained at a wide range of frequencies and operation temperatures to demonstrate the polarization phenomena and the thermally stimulated effects. Such complex permittivity measurements may be utilized as a criterion for the service life prediction of oil field electrical equipment (OFEE). Therefore, by one set of measurements on a small oil volume, data may be provided on the impending termination, or continuation of the transformer oil service life. The oil incorporating cell, attached to the appropriate measuring units, could be described as a complex permittivity sensor. In this work, the acquired dielectric data from a great number of operating distribution network power transformers were correlated to corresponding physicochemical ones to demonstrate the future potential employment of the proposed measuring technique.

Ultra-stretchable conductors based on buckled super-aligned carbon nanotube films.

PubMed

Yu, Yang; Luo, Shu; Sun, Li; Wu, Yang; Jiang, Kaili; Li, Qunqing; Wang, Jiaping; Fan, Shoushan

2015-06-14

Ultra-stretchable conductors are fabricated by coating super-aligned carbon nanotube (SACNT) films on pre-strained polydimethylsiloxane (PDMS) substrates and forming buckled SACNT structures on PDMS after release of the pre-strain. The parallel SACNT/PDMS conductors demonstrate excellent stability with normalized resistance changes of only 4.1% under an applied strain as high as 200%. The SACNT/PDMS conductors prepared with cross-stacked SACNT films show even lower resistance variation. The parallel SACNT/PDMS conductors exhibit high durability with a resistance increase of less than 5% after 10,000 cycles at 150% strain. In situ microscopic observations demonstrate that the buckled SACNT structures are straightened during the stretching process with reversible morphology evolution and thus the continuous SACNT conductive network can be protected from fracture. Due to the excellent electrical and mechanical properties of SACNT films and the formation of the buckled structure, SACNT/PDMS films exhibit high stretchability and durability, possessing great potential for use as ultra-stretchable conductors for wearable electronics, sensors, and energy storage devices.

Enzymatic production and in situ separation of natural β-ionone from β-carotene.

PubMed

Nacke, Christoph; Hüttmann, Sonja; Etschmann, Maria M W; Schrader, Jens

2012-12-01

A biotechnological process concept for generation and in situ separation of natural β-ionone from β-carotene is presented. The process employs carotenoid cleavage dioxygenases (CCDs), a plant-derived iron-containing nonheme enzyme family requiring only dissolved oxygen as cosubstrate and no additional cofactors. Organophilic pervaporation was found to be very well suited for continuous in situ separation of β-ionone. Its application led to a highly pure product despite the complexity of the reaction solution containing cell homogenates. Among three different pervaporation membrane types tested, a polyoctylmethylsiloxane active layer on a porous polyetherimide support led to the best results. A laboratory-scale demonstration plant was set up, and a highly pure aqueous-ethanolic solution of β-ionone was produced from β-carotene. The described process permits generation of high-value flavor and fragrance compounds bearing the desired label "natural" according to US and European food and safety regulations and demonstrates the potential of CCD enzymes for selective oxidative cleavage of carotenoids.

High efficiency power generation from coal and wastes utilizing high temperature air combustion technology (Part 1: Performance of pebble bed gasifier for coal and wastes)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kosaka, Hitoshi; Iwahashi, Takashi; Yoshida, Nobuhiro

1998-07-01

A new concept of a gasifier for coal and wastes is proposed where entrained bed and fixed pebble bed are combined. Main features of this pebble bed gasifier are high efficiency molten slag capture, high efficiency gasification and compactness. Coal and RFD combustion experiments using the pebble bed gasifier demonstrated high efficiency capture and continuous extraction of molten slag as well as complete char combustion with extra ordinarily short residence time of pulverized coal and crushed RDF at the temperature level of about 1,500 C within the pebble bed. Durability tests using high temperature electric furnace has shown that highmore » density alumna is a good candidate for pebble material.« less

Enabling new graduate midwives to work in midwifery continuity of care models: A conceptual model for implementation.

PubMed

Cummins, Allison M; Catling, Christine; Homer, Caroline S E

2017-12-04

High-level evidence demonstrates midwifery continuity of care is beneficial for women and babies. Women have limited access to midwifery continuity of care models in Australia. One of the factors limiting women's access is recruiting enough midwives to work in continuity. Our research found that newly graduated midwives felt well prepared to work in midwifery led continuity of care models, were well supported to work in the models and the main driver to employing them was a need to staff the models. However limited opportunities exist for new graduate midwives to work in midwifery continuity of care. The aim of this paper therefore is to describe a conceptual model developed to enable new graduate midwives to work in midwifery continuity of care models. The findings from a qualitative study were synthesised with the existing literature to develop a conceptual model that enables new graduate midwives to work in midwifery continuity of care. The model contains the essential elements to enable new graduate midwives to work in midwifery continuity of care models. Each of the essential elements discussed are to assist midwifery managers, educators and new graduates to facilitate the organisational changes required to accommodate new graduates. The conceptual model is useful to show maternity services how to enable new graduate midwives to work in midwifery continuity of care models. Copyright © 2017 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

Reconfigurable virtual electrowetting channels.

PubMed

Banerjee, Ananda; Kreit, Eric; Liu, Yuguang; Heikenfeld, Jason; Papautsky, Ian

2012-02-21

Lab-on-a-chip systems rely on several microfluidic paradigms. The first uses a fixed layout of continuous microfluidic channels. Such lab-on-a-chip systems are almost always application specific and far from a true "laboratory." The second involves electrowetting droplet movement (digital microfluidics), and allows two-dimensional computer control of fluidic transport and mixing. The merging of the two paradigms in the form of programmable electrowetting channels takes advantage of both the "continuous" functionality of rigid channels based on which a large number of applications have been developed to date and the "programmable" functionality of digital microfluidics that permits electrical control of on-chip functions. In this work, we demonstrate for the first time programmable formation of virtual microfluidic channels and their continuous operation with pressure driven flows using an electrowetting platform. Experimental, theoretical, and numerical analyses of virtual channel formation with biologically relevant electrolyte solutions and electrically-programmable reconfiguration are presented. We demonstrate that the "wall-less" virtual channels can be formed reliably and rapidly, with propagation rates of 3.5-3.8 mm s(-1). Pressure driven transport in these virtual channels at flow rates up to 100 μL min(-1) is achievable without distortion of the channel shape. We further demonstrate that these virtual channels can be switched on-demand between multiple inputs and outputs. Ultimately, we envision a platform that would provide rapid prototyping of microfluidic concepts and would be capable of a vast library of functions and benefitting applications from clinical diagnostics in resource-limited environments to rapid system prototyping to high throughput pharmaceutical applications.

Continuous- and discrete-time stimulus sequences for high stimulus rate paradigm in evoked potential studies.

PubMed

Wang, Tao; Huang, Jiang-hua; Lin, Lin; Zhan, Chang'an A

2013-01-01

To obtain reliable transient auditory evoked potentials (AEPs) from EEGs recorded using high stimulus rate (HSR) paradigm, it is critical to design the stimulus sequences of appropriate frequency properties. Traditionally, the individual stimulus events in a stimulus sequence occur only at discrete time points dependent on the sampling frequency of the recording system and the duration of stimulus sequence. This dependency likely causes the implementation of suboptimal stimulus sequences, sacrificing the reliability of resulting AEPs. In this paper, we explicate the use of continuous-time stimulus sequence for HSR paradigm, which is independent of the discrete electroencephalogram (EEG) recording system. We employ simulation studies to examine the applicability of the continuous-time stimulus sequences and the impacts of sampling frequency on AEPs in traditional studies using discrete-time design. Results from these studies show that the continuous-time sequences can offer better frequency properties and improve the reliability of recovered AEPs. Furthermore, we find that the errors in the recovered AEPs depend critically on the sampling frequencies of experimental systems, and their relationship can be fitted using a reciprocal function. As such, our study contributes to the literature by demonstrating the applicability and advantages of continuous-time stimulus sequences for HSR paradigm and by revealing the relationship between the reliability of AEPs and sampling frequencies of the experimental systems when discrete-time stimulus sequences are used in traditional manner for the HSR paradigm.

Microwave zero-resistance states in a bilayer electron system.

PubMed

Wiedmann, S; Gusev, G M; Raichev, O E; Bakarov, A K; Portal, J C

2010-07-09

Magnetotransport measurements on a high-mobility electron bilayer system formed in a wide GaAs quantum well reveal vanishing dissipative resistance under continuous microwave irradiation. Profound zero-resistance states (ZRS) appear even in the presence of additional intersubband scattering of electrons. We study the dependence of photoresistance on frequency, microwave power, and temperature. Experimental results are compared with a theory demonstrating that the conditions for absolute negative resistivity correlate with the appearance of ZRS.

CTC Sentinel. Volume 5, Issue 4, April 2012

DTIC Science & Technology

2012-04-01

Rev. 8-98) Prescribed by ANSI Std Z39-18 2 This article asserts that the FSA is foremost a national liberation movement determined to overthrow...al-Assad to grant him support, and kept the conflict a highly asymmetrical one as the outgunned FSA continues to battle well-armed, pro -regime...mil i t iamen. 16 A pro -FSA humanitarian logist ician claimed that non-lethal Iranian materiel used to suppress demonstrators was being offloaded

Recommendations for Review of TRADOC Pam 351-4(T).

DTIC Science & Technology

1981-07-08

demonstrate proficiency in performing task at speed required on the job . Overtrain - Trainee must be trained to a high standard of retention ...20, It different from Report) OI. SUPPLEMENTARY NOTES 1. KEY WORDS (Continue on reveree aide It necessary and Identify by block number) Job Analysis...the analysis effort. The terminology in 351-4 is confusing. For example, no distinction is made between job and task analysis. There are no practical

40 CFR 63.7832 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... and collect data to demonstrate continuous compliance? (a) Except for monitoring malfunctions, out-of... control activities (including as applicable, calibration checks and required zero and span adjustments... source is operating. (b) You may not use data recorded during monitoring malfunctions, associated repairs...

40 CFR 63.9922 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2013 CFR

2013-07-01

... demonstrate continuous compliance? (a) Except for monitoring malfunctions, associated repairs, and required quality assurance or control activities (including, as applicable, calibration checks and required zero... all times an affected source is operating. (b) You may not use data recorded during monitoring...

40 CFR 63.7832 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2013 CFR

2013-07-01

... and collect data to demonstrate continuous compliance? (a) Except for monitoring malfunctions, out-of... control activities (including as applicable, calibration checks and required zero and span adjustments... source is operating. (b) You may not use data recorded during monitoring malfunctions, associated repairs...

40 CFR 63.9922 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2014 CFR

2014-07-01

... demonstrate continuous compliance? (a) Except for monitoring malfunctions, associated repairs, and required quality assurance or control activities (including, as applicable, calibration checks and required zero... all times an affected source is operating. (b) You may not use data recorded during monitoring...

40 CFR 63.7832 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2014 CFR

2014-07-01

... and collect data to demonstrate continuous compliance? (a) Except for monitoring malfunctions, out-of... control activities (including as applicable, calibration checks and required zero and span adjustments... source is operating. (b) You may not use data recorded during monitoring malfunctions, associated repairs...

40 CFR 63.7832 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... and collect data to demonstrate continuous compliance? (a) Except for monitoring malfunctions, out-of... control activities (including as applicable, calibration checks and required zero and span adjustments... source is operating. (b) You may not use data recorded during monitoring malfunctions, associated repairs...

40 CFR 63.9922 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2012 CFR

2012-07-01

... demonstrate continuous compliance? (a) Except for monitoring malfunctions, associated repairs, and required quality assurance or control activities (including, as applicable, calibration checks and required zero... all times an affected source is operating. (b) You may not use data recorded during monitoring...

40 CFR 63.9922 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... demonstrate continuous compliance? (a) Except for monitoring malfunctions, associated repairs, and required quality assurance or control activities (including, as applicable, calibration checks and required zero... all times an affected source is operating. (b) You may not use data recorded during monitoring...

40 CFR 63.7832 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2012 CFR

2012-07-01

... and collect data to demonstrate continuous compliance? (a) Except for monitoring malfunctions, out-of... control activities (including as applicable, calibration checks and required zero and span adjustments... source is operating. (b) You may not use data recorded during monitoring malfunctions, associated repairs...

40 CFR 63.6630 - How do I demonstrate initial compliance with the emission limitations and operating limitations?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 13 2010-07-01 2010-07-01 false How do I demonstrate initial... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS... Hazardous Air Pollutants for Stationary Reciprocating Internal Combustion Engines Testing and Initial...

40 CFR 63.7938 - How do I demonstrate continuous compliance with the general standards?

Code of Federal Regulations, 2014 CFR

2014-07-01

... compliance with the general standards? 63.7938 Section 63.7938 Protection of Environment ENVIRONMENTAL... Remediation General Compliance Requirements § 63.7938 How do I demonstrate continuous compliance with the....7893. (2) If the remediation material treated or managed by the process vented through the affected...

40 CFR 63.7938 - How do I demonstrate continuous compliance with the general standards?

Code of Federal Regulations, 2013 CFR

2013-07-01

... compliance with the general standards? 63.7938 Section 63.7938 Protection of Environment ENVIRONMENTAL... Remediation General Compliance Requirements § 63.7938 How do I demonstrate continuous compliance with the....7893. (2) If the remediation material treated or managed by the process vented through the affected...

40 CFR 63.7938 - How do I demonstrate continuous compliance with the general standards?

Code of Federal Regulations, 2011 CFR

2011-07-01

... compliance with the general standards? 63.7938 Section 63.7938 Protection of Environment ENVIRONMENTAL... Remediation General Compliance Requirements § 63.7938 How do I demonstrate continuous compliance with the....7893. (2) If the remediation material treated or managed by the process vented through the affected...

40 CFR 63.7938 - How do I demonstrate continuous compliance with the general standards?

Code of Federal Regulations, 2012 CFR

2012-07-01

... compliance with the general standards? 63.7938 Section 63.7938 Protection of Environment ENVIRONMENTAL... Remediation General Compliance Requirements § 63.7938 How do I demonstrate continuous compliance with the....7893. (2) If the remediation material treated or managed by the process vented through the affected...

40 CFR 63.5714 - How do I demonstrate compliance if I use filled resins?

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Hazardous Air Pollutants for Boat Manufacturing Standards for Open... of PV i in equation 2 of § 63.5710. Demonstrating Compliance for Open Molding Operations Controlled...

40 CFR 63.4741 - How do I demonstrate initial compliance with the emission limitations?

Code of Federal Regulations, 2011 CFR

2011-07-01

... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Hazardous Air Pollutants: Surface Coating of... practice standards required in §§ 63.4692 and 63.4693, respectively. To demonstrate initial compliance with...

Terahertz cascades from nanoparticles

NASA Astrophysics Data System (ADS)

Arnardottir, K. B.; Liew, T. C. H.

2018-05-01

In this article we propose a system capable of terahertz (THz) radiation with quantum yield above unity. The system consists of nanoparticles where the material composition varies along the radial direction of each nanoparticle in such a way that a ladder of equidistant energy levels emerges. By then exciting the highest level of this ladder we produce multiple photons of the same frequency in the THz range. We demonstrate how we can calculate a continuous material composition profile that achieves a high quantum yield and then show that a more experimentally friendly design of a multishell nanoparticle can still result in a high quantum yield.

Mechanisms of deterioration of nutrients. [freeze drying methods for space flight food

NASA Technical Reports Server (NTRS)

Karel, M.; Flink, J. M.

1974-01-01

Methods are reported by which freeze dried foods of improved quality will be produced. The applicability of theories of flavor retention has been demonstrated for a number of food polymers, both proteins and polysacchardies. Studies on the formation of structures during freeze drying have been continued for emulsified systems. Deterioration of organoleptic quality of freeze dried foods due to high temperature heating has been evaluated and improved procedures developed. The influence of water activity and high temperature on retention of model flavor materials and browning deterioration has been evaluated for model systems and food materials.

Static FBG strain sensor with high resolution and large dynamic range by dual-comb spectroscopy.

PubMed

Kuse, Naoya; Ozawa, Akira; Kobayashi, Yohei

2013-05-06

We demonstrate a fiber Bragg grating (FBG) strain sensor with optical frequency combs. To precisely characterize the optical response of the FBG when strain is applied, dual-comb spectroscopy is used. Highly sensitive dual-comb spectroscopy of the FBG enabled strain measurements with a resolution of 34 nε. The optical spectral bandwidth of the measurement exceeds 1 THz. Compared with conventional FBG strain sensor using a continuous-wave laser that requires rather slow frequency scanning with a limited range, the dynamic range and multiplexing capability are significantly improved by using broadband dual-comb spectroscopy.

Research on radiation induced laser plasmas

NASA Technical Reports Server (NTRS)

Schneider, R. T.; Rowe, M. J.; Carter, B. D.; Walters, R. A.; Cox, J. D.; Liang, R.; Roxey, T.; Zapata, L.

1979-01-01

The development of high power nuclear pumped lasers is discussed. The excitation mechanism of continuous wave (CW) HeNe nuclear pumped lasers is studied and a CO2 nuclear pumped laser is used to demonstrate the CW output in the order of watts. The assumption that high power densities are only achievable by volume fission fragment sources is used to identify laser gases which are compatible with UF6 by excited states lifetime measurements. The examination of Xe2, XeF, and KrF under nuclear irradiation to determine if they are good candidates for nuclear-pumped lasers is described.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Yin; Wang, Wen; Wysocki, Gerard, E-mail: gwysocki@princeton.edu

In this Letter, we present a method of performing broadband mid-infrared spectroscopy with conventional, free-running, continuous wave Fabry-Perot quantum cascade lasers (FP-QCLs). The measurement method is based on multi-heterodyne down-conversion of optical signals. The sample transmission spectrum probed by one multi-mode FP-QCL is down-converted to the radio-frequency domain through an optical multi-heterodyne process using a second FP-QCL as the local oscillator. Both a broadband multi-mode spectral measurement as well as high-resolution (∼15 MHz) spectroscopy of molecular absorption are demonstrated and show great potential for development of high performance FP-laser-based spectrometers for chemical sensing.

Superaligned carbon nanotube arrays, films, and yarns: a road to applications.

PubMed

Jiang, Kaili; Wang, Jiaping; Li, Qunqing; Liu, Liang; Li, Changhong; Fan, Shoushan

2011-03-04

A superaligned carbon nanotube (CNT) array is a special kind of vertically aligned CNT array with the capability of being converted into continuous fi lms and yarns. The as-produced CNT fi lms are transparent and highly conductive, with aligned CNTs parallel to the direction of drawing. After passing through volatile solutions or being twisted, CNT fi lms can be further condensed into shrunk yarns. These shrunk yarns possess high tensile strengths and Young’s moduli, and are good conductors. Many applications of CNT fi lms and shrunk yarns have been demonstrated, such as TEM grids, loudspeakers, touch screens, etc.

High Efficiency Photonic Switch for Data Centers

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaComb, Lloyd J.; Bablumyan, Arkady; Ordyan, Armen

2016-12-06

The worldwide demand for instant access to information is driving internet growth rates above 50% annually. This rapid growth is straining the resources and architectures of existing data centers, metro networks and high performance computer centers. If the current business as usual model continues, data centers alone will require 400TWhr of electricity by 2020. In order to meet the challenges of a faster and more cost effective data centers, metro networks and supercomputing facilities, we have demonstrated a new type of optical switch that will support transmissions speeds up to 1Tb/s, and requires significantly less energy per bit than

High-repetition-rate widely tunable LiF : \\mathbf{\\mathsf{F}}_\\mathbf{\\mathsf{2}}^{-} color center lasers

NASA Astrophysics Data System (ADS)

Men, Shaojie; Liu, Zhaojun; Cong, Zhenhua; Rao, Han; Zhang, Sasa; Liu, Yang; Zverev, Petr G.; Konyushkin, Vasily A.; Zhang, Xingyu

2016-02-01

High-repetition-rate tunable LiF:\\text{F}2- color center lasers pumped by quasi-continuous-wave diode-side-pumped acousto-optically Q-switched Nd:YAG laser are demonstrated. Littrow-grating and Littman-grating tuning schemes are studied respectively. In the Littrow-grating scheme, the tuning range was 1085 nm to 1275 nm, and the maximal average output power was 275 mW. In the Littman-grating scheme, the tuning range was 1105.5 nm to 1215.5 nm, and the maximal average output power was 135 mW.

The impact of non-concordant self-report of substance use in clinical trials research.

PubMed

Clark, C Brendan; Zyambo, Cosmas M; Li, Ye; Cropsey, Karen L

2016-07-01

Studies comparing self-report substance use data to biochemical verification generally demonstrate high rates of concordance. We argue that these rates are due to the relatively high true negative rate in the general population, and high degree of honestly in treatment seeking individuals. We hypothesized that high risk individuals not seeking treatment would demonstrate low concordance and a high false negative rate of self-reported substance use. A sample of 500 individuals from a smoking cessation clinical trial was assessed over 1 year. Assessments included semi-structured interviews, questionnaires (e.g. Addiction Severity Index, etc.), and urine drug screen assays (UDS). Generalized estimating equations (GEEs) were used to predict false negative reports for various substances across the study and determine the influence of substance use on the primary study outcome of smoking cessation. Participants demonstrated high false negative rates in reporting substances use, and the false negative rates increased as the study progressed. Established predictors of false negatives generalized to the current sample. High concordance and low false negative rates were found in self-report of nicotine use. A small but significant relationship was found in for effect of biochemically verified substance use on smoking cessation. Biochemical verification of substance use is needed in high risk populations involved in studies not directly related to the treatment of substance use, especially in populations with high threat of stigmatization. Testing should continue through the time period of the study for maximal identification of substance use. Copyright © 2016 Elsevier Ltd. All rights reserved.

40 CFR 63.7120 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2011 CFR

2011-07-01

... AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Lime Manufacturing Plants Continuous Compliance Requirements § 63.7120 How do I monitor and collect data to...

40 CFR 63.7120 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2012 CFR

2012-07-01

... AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Lime Manufacturing Plants Continuous Compliance Requirements § 63.7120 How do I monitor and collect data to...

40 CFR 63.7120 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2013 CFR

2013-07-01

... AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Lime Manufacturing Plants Continuous Compliance Requirements § 63.7120 How do I monitor and collect data to...

40 CFR 63.7120 - How do I monitor and collect data to demonstrate continuous compliance?

Code of Federal Regulations, 2014 CFR

2014-07-01

... AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Lime Manufacturing Plants Continuous Compliance Requirements § 63.7120 How do I monitor and collect data to...

Time lens assisted photonic sampling extraction

NASA Astrophysics Data System (ADS)

Petrillo, Keith Gordon

Telecommunication bandwidth demands have dramatically increased in recent years due to Internet based services like cloud computing and storage, large file sharing, and video streaming. Additionally, sensing systems such as wideband radar, magnetic imaging resonance systems, and complex modulation formats to handle large data transfer in telecommunications require high speed, high resolution analog-to-digital converters (ADCs) to interpret the data. Accurately processing and acquiring the information at next generation data rates from these systems has become challenging for electronic systems. The largest contributors to the electronic bottleneck are bandwidth and timing jitter which limit speed and reduce accuracy. Optical systems have shown to have at least three orders of magnitude increase in bandwidth capabilities and state of the art mode locked lasers have reduced timing jitters into thousands of attoseconds. Such features have encouraged processing signals without the use of electronics or using photonics to assist electronics. All optical signal processing has allowed the processing of telecommunication line rates up to 1.28 Tb/s and high resolution analog-to-digital converters in the 10s of gigahertz. The major drawback to these optical systems is the high cost of the components. The application of all optical processing techniques such as a time lens and chirped processing can greatly reduce bandwidth and cost requirements of optical serial to parallel converters and push photonically assisted ADCs into the 100s of gigahertz. In this dissertation, the building blocks to a high speed photonically assisted ADC are demonstrated, each providing benefits to its own respective application. A serial to parallel converter using a continuously operating time lens as an optical Fourier processor is demonstrated to fully convert a 160-Gb/s optical time division multiplexed signal to 16 10-Gb/s channels with error free operation. Using chirped processing, an optical sample and hold concept is demonstrated and analyzed as a resolution improvement to existing photonically assisted ADCs. Simulations indicate that the application of a continuously operating time lens to a photonically assisted sampling system can increase photonically sampled systems by an order of magnitude while acquiring properties similar to an optical sample and hold system.

High Frequency Adaptive Instability Suppression Controls in a Liquid-Fueled Combustor

NASA Technical Reports Server (NTRS)

Kopasakis, George

2003-01-01

This effort extends into high frequency (>500 Hz), an earlier developed adaptive control algorithm for the suppression of thermo-acoustic instabilities in a liquidfueled combustor. The earlier work covered the development of a controls algorithm for the suppression of a low frequency (280 Hz) combustion instability based on simulations, with no hardware testing involved. The work described here includes changes to the simulation and controller design necessary to control the high frequency instability, augmentations to the control algorithm to improve its performance, and finally hardware testing and results with an experimental combustor rig developed for the high frequency case. The Adaptive Sliding Phasor Averaged Control (ASPAC) algorithm modulates the fuel flow in the combustor with a control phase that continuously slides back and forth within the phase region that reduces the amplitude of the instability. The results demonstrate the power of the method - that it can identify and suppress the instability even when the instability amplitude is buried in the noise of the combustor pressure. The successful testing of the ASPAC approach helped complete an important NASA milestone to demonstrate advanced technologies for low-emission combustors.

Microfluidic-SANS: insitu molecular insight into complex fluid processing and high throughput characterisation

NASA Astrophysics Data System (ADS)

Lopez, Carlos; Watanabe, Takaichi; Cabral, Joao; Graham, Peter; Porcar, Lionel; Martel, Anne

2014-03-01

The coupling of microfluidics and small angle neutron scattering (SANS) is successfully demonstrated for the first time. We have developed novel microdevices with suitably low SANS background and high pressure compatibility for the investigation of flow-induced phenomena and high throughput phase mapping of complex fluids. We successfully obtained scattering profiles from 50 micron channels, in 10s - 100s second acquisition times. The microfluidic geometry enables the variation of both flow type and magnitude, beyond traditional rheo-SANS setups, and is exceptionally well-suited for complex fluids due to the commensurability of relevant time and lengthscales. We demonstrate our approach by studying model flow responsive systems, including surfactant/co-surfactant/water mixtures, with well-known equilibrium phase behaviour,: sodium dodecyl sulfate (SDS)/octanol/brine, cetyltrimethyl ammonium chloride (C16TAC)/pentanol/water and a model microemulsion system (C10E4 /decane/ D20), as well as polyelectrolyte solutions. Finally, using an online micromixer we are able to implement a high throughput approach, scanning in excess of 10 scattering profiles/min for a continuous aqueous surfactant dilution over two decades in concentration.

Low-intensity continuous ultrasound triggers effective bisphosphonate anticancer activity in breast cancer.

PubMed

Tardoski, Sophie; Ngo, Jacqueline; Gineyts, Evelyne; Roux, Jean-Paul; Clézardin, Philippe; Melodelima, David

2015-11-18

Ultrasound (US) is a non-ionizing pressure wave that can produce mechanical and thermal effects. Bisphosphonates have demonstrated clinical utility in bone metastases treatment. Preclinical studies suggest that bisphosphonates have anticancer activity. However, bisphosphonates exhibit a high affinity for bone mineral, which reduces their bioavailability for tumor cells. Ultrasound has been shown to be effective for drug delivery but in interaction with gas bubbles or encapsulated drugs. We examined the effects of a clinically relevant dose of bisphosphonate zoledronate (ZOL) in combination with US. In a bone metastasis model, mice treated with ZOL+US had osteolytic lesions that were 58% smaller than those of ZOL-treated animals as well as a reduced skeletal tumor burden. In a model of primary tumors, ZOL+US treatment reduced by 42% the tumor volume, compared with ZOL-treated animals. Using a fluorescent bisphosphonate, we demonstrated that US forced the release of bisphosphonate from the bone surface, enabling a continuous impregnation of the bone marrow. Additionally, US forced the penetration of ZOL within tumors, as demonstrated by the intratumoral accumulation of unprenylated Rap1A, a surrogate marker of ZOL antitumor activity. Our findings made US a promising modality to trigger bisphosphonate anticancer activity in bone metastases and in primary tumors.

Bioprocessing of a stored mixed liquid waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolfram, J.H.; Rogers, R.D.; Finney, R.

1995-12-31

This paper describes the development and results of a demonstration for a continuous bioprocess for mixed waste treatment. A key element of the process is an unique microbial strain which tolerates high levels of aromatic solvents and surfactants. This microorganism is the biocatalysis of the continuous flow system designed for the processing of stored liquid scintillation wastes. During the past year a process demonstration has been conducted on commercial formulation of liquid scintillation cocktails (LSC). Based on data obtained from this demonstration, the Ohio EPA granted the Mound Applied Technologies Lab a treatability permit allowing the limited processing of actualmore » mixed waste. Since August 1994, the system has been successfully processing stored, {open_quotes}hot{close_quotes} LSC waste. The initial LSC waste fed into the system contained 11% pseudocumene and detectable quantities of plutonium. Another treated waste stream contained pseudocumene and tritium. Data from this initial work shows that the hazardous organic solvent, and pseudocumene have been removed due to processing, leaving the aqueous low level radioactive waste. Results to date have shown that living cells are not affected by the dissolved plutonium and that 95% of the plutonium was sorbed to the biomass. This paper discusses the bioprocess, rates of processing, effluent, and the implications of bioprocessing for mixed waste management.« less

Low-intensity continuous ultrasound triggers effective bisphosphonate anticancer activity in breast cancer

NASA Astrophysics Data System (ADS)

Tardoski, Sophie; Ngo, Jacqueline; Gineyts, Evelyne; Roux, Jean-Paul; Clézardin, Philippe; Melodelima, David

2015-11-01

Ultrasound (US) is a non-ionizing pressure wave that can produce mechanical and thermal effects. Bisphosphonates have demonstrated clinical utility in bone metastases treatment. Preclinical studies suggest that bisphosphonates have anticancer activity. However, bisphosphonates exhibit a high affinity for bone mineral, which reduces their bioavailibity for tumor cells. Ultrasound has been shown to be effective for drug delivery but in interaction with gas bubbles or encapsulated drugs. We examined the effects of a clinically relevant dose of bisphosphonate zoledronate (ZOL) in combination with US. In a bone metastasis model, mice treated with ZOL+US had osteolytic lesions that were 58% smaller than those of ZOL-treated animals as well as a reduced skeletal tumor burden. In a model of primary tumors, ZOL+US treatment reduced by 42% the tumor volume, compared with ZOL-treated animals. Using a fluorescent bisphosphonate, we demonstrated that US forced the release of bisphosphonate from the bone surface, enabling a continuous impregnation of the bone marrow. Additionally, US forced the penetration of ZOL within tumors, as demonstrated by the intratumoral accumulation of unprenylated Rap1A, a surrogate marker of ZOL antitumor activity. Our findings made US a promising modality to trigger bisphosphonate anticancer activity in bone metastases and in primary tumors.

Continuous monitoring bed-level dynamics on an intertidal flat: introducing novel stand-alone high-resolution SED-sensors

NASA Astrophysics Data System (ADS)

Hu, Zhan; Lenting, Walther; van der Wal, Daphne; Bouma, Tjeerd

2015-04-01

Tidal flat morphology is continuously shaped by hydrodynamic force, resulting in highly dynamic bed elevations. The knowledge of short-term bed-level changes is important both for understanding sediment transport processes as well as for assessing critical ecological processes such as e.g. vegetation recruitment chances on tidal flats. Due to the labour involved, manual discontinuous measurements lack the ability to continuously monitor bed-elevation changes. Existing methods for automated continuous monitoring of bed-level changes lack vertical accuracy (e.g., Photo-Electronic Erosion Pin sensor and resistive rod) or limited in spatial application by using expensive technology (e.g., acoustic bed level sensors). A method provides sufficient accuracy with a reasonable cost is needed. In light of this, a high-accuracy sensor (2 mm) for continuously measuring short-term Surface-Elevation Dynamics (SED-sensor) was developed. This SED-sensor makes use of photovoltaic cells and operates stand-alone using internal power supply and data logging system. The unit cost and the labour in deployments is therefore reduced, which facilitates monitoring with a number of units. In this study, the performance of a group of SED-sensors is tested against data obtained with precise manual measurements using traditional Sediment Erosion Bars (SEB). An excellent agreement between the two methods was obtained, indicating the accuracy and precision of the SED-sensors. Furthermore, to demonstrate how the SED-sensors can be used for measuring short-term bed-level dynamics, two SED-sensors were deployed for 1 month at two sites with contrasting wave exposure conditions. Daily bed-level changes were obtained including a severe storm erosion event. The difference in observed bed-level dynamics at both sites was statistically explained by their different hydrodynamic conditions. Thus, the stand-alone SED-sensor can be applied to monitor sediment surface dynamics with high vertical and temporal resolutions, which provides opportunities to pinpoint morphological responses to various forces in a number of environments (e.g. tidal flats, beaches, rivers and dunes).

WISPER: Wirless Space Power Experiment

NASA Technical Reports Server (NTRS)

Hawkins, Joseph

1993-01-01

The 1993 Advanced Design Project at the University of Alaska Fairbanks was to design a spacecraft as a technology demonstration of wireless power transmission (WPT). With cost effectiveness as a design constraint, a micro-satellite in low earth orbit (LEO) was chosen for the mission. Existing and near term technologies were analyzed and selected for the project. In addition to the conceptual design of the payload, support systems, and structure, the analysis included attention to safety, environmental impact, cost, and schedule for construction and operation. Wireless power beaming is not a new concept. Experimental demonstrations and study efforts have continued since the early 1960's. With the latest progress in transmitter and receiver technology, the next natural step is to beam power from earth to space. This proposed flight demonstration will advance the science of power beaming and prove the viability of various applications of WPT in space. Two methods of power beaming will be examined during the two separate phases of the spacecraft life. The first phase will demonstrate the technology and examine the theory of microwave power transmission at a high frequency. Special aspects of the first phase will include a highly accurate attitude control system and a 14 m inflatable parabolic antenna. The second phase will investigate the utilization of high intensity laser power using modified photovoltaic arrays. Special instrumentation on the spacecraft will measure the conversion efficiency from the received microwave or laser power to direct current power.

Soliton Microwave Generator

NASA Astrophysics Data System (ADS)

Degrassie, J. S.

1990-12-01

The Soliton Microwave Generator (SMG) represents a truly new concept in the field of high power microwave (HPM) generation. A nonlinear, dispersive transmission line is used to convert an input voltage pulse into an HPM burst at the output. The system is all solid state and projects to be efficient and reliable. Single module peak powers in excess of 1 GW appear feasible, while combining modular units leads to a 10 GW system projection. This project for the DOE has allowed the first steps necessary in experimentally demonstrating the SMG. The project has ended successfully. A relatively high power lumped circuit SMG operating in the uhf band was designed, fabricated, and tested. The maximum peak output RF power was 16 MW from this line approx. 90 cm in length and 2 sq cm in cross section with a peak power efficiency of roughly 20 percent. Additionally a low power continuous strip-line approach demonstrated microwave generation well into L band, at approx. 2 GHz.

[Collective immunity against poliomyelitis among the population of several regions of Russia].

PubMed

Seybil, V B; Malyshkina, L P; Ageeva, O T; Kosolapova, E I; Mnozhina, E G; Groshenkova, E V; Krivtsov, N V; Gurianova, N I; Daltsaeva, M K; Fomina, N S

2015-01-01

The goal of this work was to estimate the collective immunity against poliomyelitis among the population of 8 regions and republics of Russia. The rates of the collective immunity against poliomyelitis allow the polio vaccination quality to be estimated and the population protection rate to be simultaneously demonstrated. A total of 8 regions (2138 people) were tested. The antibodies to the polioviruses of 1-3 types were determined against the vaccine Sabin strains in the neutralization test in the RD cell line. As a result, we found that vaccination against poliomyelitis in all observed regions was maintained at the required high level. Thus, the number of people with antibodies to the polio in most regions and age groups approximates or reaches 100%, while GMT is also high. This work demonstrated the necessity of the continuation of vaccination against poliomyelitis and control over collective immunity.

Development and testing of a 180-volt dc electronic circuit breaker with a 335-ampere carry and 1200-ampere interrupt rating

NASA Technical Reports Server (NTRS)

Brush, A. S.; Phillips, R. L.

1991-01-01

NASA Lewis Research Center and associated contractors have conducted a program to assess the potential requirements for a high-current switch to conceptually design a switch using the best existing technology, and to build and demonstrate a breadboard which meets the requirements. The result is the high current remote bus isolator (HRBI). The HRBI is rated at 180 V dc, 335 A continuous with a 1200 A interrupt rating. It also incorporates remote-control and protective features called for by the Space Station Freedom PMAD dc test bed design. Two breadboard 335 A circuit breakers were built and tested that demonstrate a promising concept of paralleled current-limiting modules. The units incorporated all control and protective features required by advanced aerospace power systems. Component stresses in each unit were determined by design, and are consistent with a life of many thousands of fault operations.

Continuous cytokine haemoadsorption incorporated into a venoarterial ECMO circuit for the management of postcardiotomy cardiogenic and septic shock - a case report.

PubMed

Nemeth, Endre; Szigeti, Szabolcs; Varga, Tamas; Daroczi, Laszlo; Barati, Zoltan; Merkely, Bela; Gal, Janos

2018-05-01

The acute surgical treatment of infective endocarditis (IE) carries a high risk of postoperative mortality. Most complications are linked to uncontrolled sepsis and inflammatory processes. Cytokine haemoadsorption is an extracorporeal technique which has benefits reported in haemodynamic stability and inflammatory response. A 46-year-old male patient underwent emergency cardiac surgery due to progressive IE. Postcardiotomy cardiogenic shock associated with cardiac surgery required the implantation of venoarterial (VA)-ECMO. Three days later, the patient developed secondary septic shock. The novel application of continuous CytoSorb TM treatment installed in the VA-ECMO circuit is demonstrated in this case during the management of simultaneous shocks. Advanced intensive care led to an improvement in the patient's condition, which facilitated successful weaning from mechanical ventilation. However, the patient died from a new onset fulminant septic shock two months after his initial cardiac surgery. VA-ECMO is suitable for installation of the CytoSorb TM cartridge. This modality could be an option for high-volume, continuous cytokine haemoadsorption when VA-ECMO is employed without renal replacement therapy. This specific application of CytoSorb TM was safe, feasible and contributed to the optimal management of simultaneous shocks.

Continuous, highly flexible, and transparent graphene films by chemical vapor deposition for organic photovoltaics.

PubMed

Gomez De Arco, Lewis; Zhang, Yi; Schlenker, Cody W; Ryu, Koungmin; Thompson, Mark E; Zhou, Chongwu

2010-05-25

We report the implementation of continuous, highly flexible, and transparent graphene films obtained by chemical vapor deposition (CVD) as transparent conductive electrodes (TCE) in organic photovoltaic cells. Graphene films were synthesized by CVD, transferred to transparent substrates, and evaluated in organic solar cell heterojunctions (TCE/poly-3,4-ethylenedioxythiophene:poly styrenesulfonate (PEDOT:PSS)/copper phthalocyanine/fullerene/bathocuproine/aluminum). Key to our success is the continuous nature of the CVD graphene films, which led to minimal surface roughness ( approximately 0.9 nm) and offered sheet resistance down to 230 Omega/sq (at 72% transparency), much lower than stacked graphene flakes at similar transparency. In addition, solar cells with CVD graphene and indium tin oxide (ITO) electrodes were fabricated side-by-side on flexible polyethylene terephthalate (PET) substrates and were confirmed to offer comparable performance, with power conversion efficiencies (eta) of 1.18 and 1.27%, respectively. Furthermore, CVD graphene solar cells demonstrated outstanding capability to operate under bending conditions up to 138 degrees , whereas the ITO-based devices displayed cracks and irreversible failure under bending of 60 degrees . Our work indicates the great potential of CVD graphene films for flexible photovoltaic applications.

In situ real-time measurement of physical characteristics of airborne bacterial particles

NASA Astrophysics Data System (ADS)

Jung, Jae Hee; Lee, Jung Eun

2013-12-01

Bioaerosols, including aerosolized bacteria, viruses, and fungi, are associated with public health and environmental problems. One promising control method to reduce the harmful effects of bioaerosols is thermal inactivation via a continuous-flow high-temperature short-time (HTST) system. However, variations in bioaerosol physical characteristics - for example, the particle size and shape - during the continuous-flow inactivation process can change the transport properties in the air, which can affect particle deposition in the human respiratory system or the filtration efficiency of ventilation systems. Real-time particle monitoring techniques are a desirable alternative to the time-consuming process of microscopic analysis that is conventionally used in sampling and particle characterization. Here, we report in situ real-time optical scattering measurements of the physical characteristics of airborne bacteria particles following an HTST process in a continuous-flow system. Our results demonstrate that the aerodynamic diameter of bacterial aerosols decreases when exposed to a high-temperature environment, and that the shape of the bacterial cells is significantly altered. These variations in physical characteristics using optical scattering measurements were found to be in agreement with the results of scanning electron microscopy analysis.

A hybrid single-end-access MZI and Φ-OTDR vibration sensing system with high frequency response

NASA Astrophysics Data System (ADS)

Zhang, Yixin; Xia, Lan; Cao, Chunqi; Sun, Zhenhong; Li, Yanting; Zhang, Xuping

2017-01-01

A hybrid single-end-access Mach-Zehnder interferometer (MZI) and phase sensitive OTDR (Φ-OTDR) vibration sensing system is proposed and demonstrated experimentally. In our system, the narrow optical pulses and the continuous wave are injected into the fiber through the front end of the fiber at the same time. And at the rear end of the fiber, a frequency-shift-mirror (FSM) is designed to back propagate the continuous wave modulated by the external vibration. Thus the Rayleigh backscattering signals (RBS) and the back propagated continuous wave interfere with the reference light at the same end of the sensing fiber and a single-end-access configuration is achieved. The RBS can be successfully separated from the interference signal (IS) through digital signal process due to their different intermediate frequency based on frequency division multiplexing technique. There is no influence between these two schemes. The experimental results show 10 m spatial resolution and up to 1.2 MHz frequency response along a 6.35 km long fiber. This newly designed single-end-access setup can achieve vibration events locating and high frequency events response, which can be widely used in health monitoring for civil infrastructures and transportation.

Synthesis and electroplating of high resolution insulated carbon nanotube scanning probes for imaging in liquid solutions

PubMed Central

Roberts, N.A.; Noh, J.H.; Lassiter, M.G.; Guo, S.; Kalinin, S.V.; Rack, P.D.

2012-01-01

High resolution and isolated scanning probe microscopy (SPM) is in demand for continued development of energy storage and conversion systems involving chemical reactions at the nanoscale as well as an improved understanding of biological systems. Carbon nanotubes (CNTs) have large aspect ratios and, if leveraged properly, can be used to develop high resolution SPM probes. Isolation of SPM probes can be achieved by deposited a dielectric film and selectively etching at the apex of the probe. In this paper the fabrication of a high resolution and isolated SPM tip is demonstrated using electron beam induced etching of a dielectric film deposited onto an SPM tip with an attached CNT at the apex. PMID:22433664

Synthesis and electroplating of high resolution insulated carbon nanotube scanning probes for imaging in liquid solutions.

PubMed

Roberts, N A; Noh, J H; Lassiter, M G; Guo, S; Kalinin, S V; Rack, P D

2012-04-13

High resolution and isolated scanning probe microscopy (SPM) is in demand for continued development of energy storage and conversion systems involving chemical reactions at the nanoscale as well as an improved understanding of biological systems. Carbon nanotubes (CNTs) have large aspect ratios and, if leveraged properly, can be used to develop high resolution SPM probes. Isolation of SPM probes can be achieved by depositing a dielectric film and selectively etching at the apex of the probe. In this paper the fabrication of a high resolution and isolated SPM tip is demonstrated using electron beam induced etching of a dielectric film deposited onto an SPM tip with an attached CNT at the apex.

Architectural Options for a Future Deep Space Optical Communications Network

NASA Technical Reports Server (NTRS)

Edwards, B. L.; Benjamin, T.; Scozzafava, J.; Khatri, F.; Sharma, J.; Parvin, B.; Liebrecht, P. E.; Fitzgerald, R. J.

2004-01-01

This paper provides an overview of different options at Earth to provide Deep Space optical communication services. It is based mainly on work done for the Mars Laser Communications Demonstration (MLCD) Project, a joint project between NASA's Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory, California Institute of Technology (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT/LL). It also reports preliminary conclusions from the Tracking and Data Relay Satellite System Continuation Study at GSFC. A lasercom flight terminal will be flown on the Mars Telecommunications Orbiter (MTO) to be launched by NASA in 2009, and will be the first high rate deep space demonstration of this revolutionary technology.

Comparative study of Nd:KGW lasers pumped at 808 nm and 877 nm

NASA Astrophysics Data System (ADS)

Huang, Ke; Ge, Wen-Qi; Zhao, Tian-Zhuo; He, Jian-Guo; Feng, Chen-Yong; Fan, Zhong-Wei

2015-10-01

The laser performance and thermal analysis of Nd:KGW laser continuously pumped by 808 nm and 877 nm are comparatively investigated. Output power of 670 mW and 1587 mW, with nearly TEM00 mode, are achieved respectively at 808 nm pump and 877 nm pump. Meanwhile, a high-power passively Q-switched Nd:KGW/Cr4+:YAG laser pumped at 877 nm is demonstrated. An average output power of 1495 mW is obtained at pump power of 5.22 W while the laser is operating at repetition of 53.17 kHz. We demonstrate that 877 nm diode laser is a more potential pump source for Nd:KGW lasers.

Advances in the design of common pressure vessel nickel hydrogen batteries for aerospace applications

NASA Technical Reports Server (NTRS)

Zagrodnik, Jeffrey P.; Jones, Kenneth R.

1991-01-01

Over 7000 low-earth-orbit (LEO) cycles were demonstrated on a full-size aerospace common pressure vessel (CPV) prototype. The battery demonstrated the capability of the basic CPV design to meet the life and reliability requirements of aerospace missions. Subsequent design modifications have been employed to address the shortcomings of the original design and several new prototypes have been fabricated. These include a 12-cell 125 amp-hour geosynchronous earth-orbit (GEO) battery and a 22-cell 10.5 amp-hour LEO battery. Cells for an 80-cell battery intended to demonstrate the high voltage capability of the CPV design have also been fabricated. In addition, assembly of a 20-cell aircraft starting battery prototype is in progress, and testing of a group of 12-volt, 160 amp-hour terrestrial batteries is continuing.