Structural zooming research and development of an interactive computer graphical interface for stress analysis of cracks

NASA Technical Reports Server (NTRS)

Gerstle, Walter

1989-01-01

Engineering problems sometimes involve the numerical solution of boundary value problems over domains containing geometric feature with widely varying scales. Often, a detailed solution is required at one or more of these features. Small details in large structures may have profound effects upon global performance. Conversely, large-scale conditions may effect local performance. Many man-hours and CPU-hours are currently spent in modeling such problems. With the structural zooming technique, it is now possible to design an integrated program which allows the analyst to interactively focus upon a small region of interest, to modify the local geometry, and then to obtain highly accurate responses in that region which reflect both the properties of the overall structure and the local detail. A boundary integral equation analysis program, called BOAST, was recently developed for the stress analysis of cracks. This program can accurately analyze two-dimensional linear elastic fracture mechanics problems with far less computational effort than existing finite element codes. An interactive computer graphical interface to BOAST was written. The graphical interface would have several requirements: it would be menu-driven, with mouse input; all aspects of input would be entered graphically; the results of a BOAST analysis would be displayed pictorially but also the user would be able to probe interactively to get numerical values of displacement and stress at desired locations within the analysis domain; the entire procedure would be integrated into a single, easy to use package; and it would be written using calls to the graphic package called HOOPS. The program is nearing completion. All of the preprocessing features are working satisfactorily and were debugged. The postprocessing features are under development, and rudimentary postprocessing should be available by the end of the summer. The program was developed and run on a VAX workstation, and must be ported to the SUN workstation. This activity is currently underway.

Highly Shocked Low Density Sedimentary Rocks from the Haughton Impact Structure, Devon Island, Nunavut, Canada

NASA Technical Reports Server (NTRS)

Osinski, G. R.; Spray, J. G.

2001-01-01

We present the preliminary results of a detailed investigation of the shock effects in highly shocked, low density sedimentary rocks from the Haughton impact structure. We suggest that some textural features can be explained by carbonate-silicate immiscibility. Additional information is contained in the original extended abstract.

High Accuracy 3D Processing of Satellite Imagery

NASA Technical Reports Server (NTRS)

Gruen, A.; Zhang, L.; Kocaman, S.

2007-01-01

Automatic DSM/DTM generation reproduces not only general features, but also detailed features of the terrain relief. Height accuracy of around 1 pixel in cooperative terrain. RMSE values of 1.3-1.5 m (1.0-2.0 pixels) for IKONOS and RMSE values of 2.9-4.6 m (0.5-1.0 pixels) for SPOT5 HRS. For 3D city modeling, the manual and semi-automatic feature extraction capability of SAT-PP provides a good basis. The tools of SAT-PP allowed the stereo-measurements of points on the roofs in order to generate a 3D city model with CCM The results show that building models with main roof structures can be successfully extracted by HRSI. As expected, with Quickbird more details are visible.

Observational Tests of the Mars Ocean Hypothesis: Selected MOC and MOLA Results

NASA Technical Reports Server (NTRS)

Parker, T. J.; Banerdt, W. B.

1999-01-01

We have begun a detailed analysis of the evidence for and topography of features identified as potential shorelines that have been im-aged by the Mars Orbiter Camera (MOC) during the Aerobraking Hiatus and Science Phasing Orbit periods of the Mars Global Surveyor (MGS) mission. MOC images, comparable in resolution to high-altitude terrestrial aerial photographs, are particularly well suited to address the morphological expressions of these features at scales comparable to known shore morphologies on Earth. Particularly useful are examples of detailed relationships between potential shore features, such as erosional (and depositional) terraces have been cut into "familiar" pre-existing structures and topography in a fashion that points to a shoreline interpretation as the most likely mechanism for their formation. Additional information is contained in the original extended abstract.

Antenatal diagnosis of complete facial duplication--a case report of a rare craniofacial defect.

PubMed

Rai, V S; Gaffney, G; Manning, N; Pirrone, P G; Chamberlain, P F

1998-06-01

We report a case of the prenatal sonographic detection of facial duplication, the diprosopus abnormality, in a twin pregnancy. The characteristic sonographic features of the condition include duplication of eyes, mouth, nose and both mid- and anterior intracranial structures. A heart-shaped abnormality of the cranial vault should prompt more detailed examination for other supportive features of this rare condition.

Multiple beam interference confocal microscopy: a tool for morphological investigation of living cells and tissues

NASA Astrophysics Data System (ADS)

Joshi, Narahari V.; Medina, Honorio

2000-05-01

Multiple beam interference system is used in conjunction with a conventional scanning confocal microscope to examine the morphology and construction of 3D images of Histolytic Ameba and parasite Candida Albicans. The present combination permits to adjoin advantages of both systems, namely the vertical high contrast and optical sectioning. The interference pattern obtained from a multiple internal reflection of a simple, sandwiched between the glass plate and the cover plate, was focussed on an objective of a scanning confocal microscope. According to optical path differences, morphological details were revealed. The combined features, namely improved resolution in z axis, originated from the interference pattern and the optical sectioning of the confocal scanning system, enhance the resolution and contrast dramatically. These features permitted to obtain unprecedented images of Histolytic Ameba and parasite Candida Albicans. Because of the improved contrast, several details like double wall structure of candida, internal structure of ameba are clearly visible.

Aging in complex interdependency networks.

PubMed

Vural, Dervis C; Morrison, Greg; Mahadevan, L

2014-02-01

Although species longevity is subject to a diverse range of evolutionary forces, the mortality curves of a wide variety of organisms are rather similar. Here we argue that qualitative and quantitative features of aging can be reproduced by a simple model based on the interdependence of fault-prone agents on one other. In addition to fitting our theory to the empiric mortality curves of six very different organisms, we establish the dependence of lifetime and aging rate on initial conditions, damage and repair rate, and system size. We compare the size distributions of disease and death and see that they have qualitatively different properties. We show that aging patterns are independent of the details of interdependence network structure, which suggests that aging is a many-body effect, and that the qualitative and quantitative features of aging are not sensitively dependent on the details of dependency structure or its formation.

Hierarchical Recurrent Neural Hashing for Image Retrieval With Hierarchical Convolutional Features.

PubMed

Lu, Xiaoqiang; Chen, Yaxiong; Li, Xuelong

Hashing has been an important and effective technology in image retrieval due to its computational efficiency and fast search speed. The traditional hashing methods usually learn hash functions to obtain binary codes by exploiting hand-crafted features, which cannot optimally represent the information of the sample. Recently, deep learning methods can achieve better performance, since deep learning architectures can learn more effective image representation features. However, these methods only use semantic features to generate hash codes by shallow projection but ignore texture details. In this paper, we proposed a novel hashing method, namely hierarchical recurrent neural hashing (HRNH), to exploit hierarchical recurrent neural network to generate effective hash codes. There are three contributions of this paper. First, a deep hashing method is proposed to extensively exploit both spatial details and semantic information, in which, we leverage hierarchical convolutional features to construct image pyramid representation. Second, our proposed deep network can exploit directly convolutional feature maps as input to preserve the spatial structure of convolutional feature maps. Finally, we propose a new loss function that considers the quantization error of binarizing the continuous embeddings into the discrete binary codes, and simultaneously maintains the semantic similarity and balanceable property of hash codes. Experimental results on four widely used data sets demonstrate that the proposed HRNH can achieve superior performance over other state-of-the-art hashing methods.Hashing has been an important and effective technology in image retrieval due to its computational efficiency and fast search speed. The traditional hashing methods usually learn hash functions to obtain binary codes by exploiting hand-crafted features, which cannot optimally represent the information of the sample. Recently, deep learning methods can achieve better performance, since deep learning architectures can learn more effective image representation features. However, these methods only use semantic features to generate hash codes by shallow projection but ignore texture details. In this paper, we proposed a novel hashing method, namely hierarchical recurrent neural hashing (HRNH), to exploit hierarchical recurrent neural network to generate effective hash codes. There are three contributions of this paper. First, a deep hashing method is proposed to extensively exploit both spatial details and semantic information, in which, we leverage hierarchical convolutional features to construct image pyramid representation. Second, our proposed deep network can exploit directly convolutional feature maps as input to preserve the spatial structure of convolutional feature maps. Finally, we propose a new loss function that considers the quantization error of binarizing the continuous embeddings into the discrete binary codes, and simultaneously maintains the semantic similarity and balanceable property of hash codes. Experimental results on four widely used data sets demonstrate that the proposed HRNH can achieve superior performance over other state-of-the-art hashing methods.

Three-Dimensional Geologic Framework Model for a Karst Aquifer System, Hasty and Western Grove Quadrangles, Northern Arkansas

USGS Publications Warehouse

Turner, Kenzie J.; Hudson, Mark R.; Murray, Kyle E.; Mott, David N.

2007-01-01

Understanding ground-water flow in a karst aquifer benefits from a detailed conception of the three-dimensional (3D) geologic framework. Traditional two-dimensional products, such as geologic maps, cross-sections, and structure contour maps, convey a mental picture of the area but a stronger conceptualization can be achieved by constructing a digital 3D representation of the stratigraphic and structural geologic features. In this study, a 3D geologic model was created to better understand a karst aquifer system in the Buffalo National River watershed in northern Arkansas. The model was constructed based on data obtained from recent, detailed geologic mapping for the Hasty and Western Grove 7.5-minute quadrangles. The resulting model represents 11 stratigraphic zones of Ordovician, Mississippian, and Pennsylvanian age. As a result of the highly dissected topography, stratigraphic and structural control from geologic contacts and interpreted structure contours were sufficient for effectively modeling the faults and folds in the model area. Combined with recent dye-tracing studies, the 3D framework model is useful for visualizing the various geologic features and for analyzing the potential control they exert on the ground-water flow regime. Evaluation of the model, by comparison to published maps and cross-sections, indicates that the model accurately reproduces both the surface geology and subsurface geologic features of the area.

Structural Feature Ions for Distinguishing N- and O-Linked Glycan Isomers by LC-ESI-IT MS/MS

NASA Astrophysics Data System (ADS)

Everest-Dass, Arun V.; Abrahams, Jodie L.; Kolarich, Daniel; Packer, Nicolle H.; Campbell, Matthew P.

2013-06-01

Glycomics is the comprehensive study of glycan expression in an organism, cell, or tissue that relies on effective analytical technologies to understand glycan structure-function relationships. Owing to the macro- and micro-heterogeneity of oligosaccharides, detailed structure characterization has required an orthogonal approach, such as a combination of specific exoglycosidase digestions, LC-MS/MS, and the development of bioinformatic resources to comprehensively profile a complex biological sample. Liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS) has emerged as a key tool in the structural analysis of oligosaccharides because of its high sensitivity, resolution, and robustness. Here, we present a strategy that uses LC-ESI-MS/MS to characterize over 200 N- and O-glycans from human saliva glycoproteins, complemented by sequential exoglycosidase treatment, to further verify the annotated glycan structures. Fragment-specific substructure diagnostic ions were collated from an extensive screen of the literature available on the detailed structural characterization of oligosaccharides and, together with other specific glycan structure feature ions derived from cross-ring and glycosidic-linkage fragmentation, were used to characterize the glycans and differentiate isomers. The availability of such annotated mass spectrometric fragmentation spectral libraries of glycan structures, together with such substructure diagnostic ions, will be key inputs for the future development of the automated elucidation of oligosaccharide structures from MS/MS data.

Ion spectral structures observed by the Van Allen Probes

NASA Astrophysics Data System (ADS)

Ferradas, C.; Zhang, J.; Spence, H. E.; Kistler, L. M.; Larsen, B.; Reeves, G. D.; Skoug, R. M.; Funsten, H. O.

2015-12-01

During the last decades several missions have recorded the presence of dynamic spectral features of energetic ions in the inner magnetosphere. Previous studies have reported single "nose-like" structures occurring alone and simultaneous nose-like structures (up to three). These ion structures are named after the characteristic shapes of energy bands or gaps in the energy-time spectrograms of in situ measured ion fluxes. They constitute the observational signatures of ion acceleration, transport, and loss in the global magnetosphere. The HOPE mass spectrometer onboard the Van Allen Probes measures energetic hydrogen, helium, and oxygen ions near the inner edge of the plasma sheet, where these ion structures are observed. We present a statistical study of nose-like structures, using 2-years measurements from the HOPE instrument. The results provide important details about the spatial distribution (dependence on geocentric distance), spectral features of the structures (differences among species), and geomagnetic conditions under which these structures occur.

PROPANE BUBBLE CHAMBER (in Italian)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loria, A.; Mittner, P.; Scotoni, I.

1959-03-01

A propane bubble chamber of about two liters volume is described: details concerning the membrane expansion mechanism, the structure of the windows and the illuminating system are given. Some features of the use of it, recently made at the CERN synchrocyclotron, are indicated. (auth)

A Possible Buried Impact Structure Near Bow City, Alberta

NASA Astrophysics Data System (ADS)

Xie, W.; Glombick, P.; Schmitt, D. R.; Bown, T. D.

2012-12-01

In recent years, improved exploration techniques have resulted in the serendipitous discoveries of increasing numbers of extraterrestrial impact structures in sedimentary basins around the world. Following in this tradition, a new potential impact structure centered near 50.4°N, 112.35°N in SE Alberta has been identified. The first indications of this structure appeared in careful systematic mapping of Cretaceous age sediments using public domain well log information that showed overturned and missing components in what regionally is a simple layered stratigraphy. This motivated the examination of legacy 2D seismic profiles over the area that confirmed the stratigraphic anomalies and provided new details that further supported interpretation of a potential impact structure. Further, the existence of unexpected faults through the Cretaceous Bearpaw formation had been noted as early as the 1940's in the limited outcrop available in coulees, and these as well as other complex fault structures along the Bow River outcrops were confirmed in recent field visits to the site. The 2D seismic data displays a number of listric and rose-petal faulting consistent with late stage collapse of the impact crater. Further, a seismically transparent central uplift peak is visible. Based on the results, the structure is recognized as a complex crater with a diameter of approximately 8 kilometers and, today, bottoming at a depth of 900 meters from the current surface. Currently, the age of the feature is grossly estimated to be less than 70 my on the basis of underlying undisturbed seismic reflectors. The structure may be somewhat unique in that weak coals surrounding the feature are clearly thickened indicating outward lateral sliding along shear planes through weaker layers. Work in progress includes acquisition of a high resolution seismic profile and detailed mapping of the magnetic and gravity potential fields. More detailed mapping will include searches for shock metamorphism and melt although it is not likely that this will be seen in the current outcrop. Drilling may be necessary to confirm details of the structure.

Geologic map of the Metis Mons quadrangle (V–6), Venus

USGS Publications Warehouse

Dohm, James M.; Tanaka, Kenneth L.; Skinner, James A.

2011-01-01

The Metis Mons quadrangle (V–6) in the northern hemisphere of Venus (lat 50° to 75° N., long 240° to 300° E.) includes a variety of coronae, large volcanoes, ridge and fracture (structure) belts, tesserae, impact craters, and other volcanic and structural features distributed within a plains setting, affording study of their detailed age relations and evolutionary development. Coronae in particular have magmatic, tectonic, and topographic signatures that indicate complex evolutionary histories. Previously, the geology of the map region has been described either in general or narrowly focused investigations. Based on Venera radar mapping, a 1:15,000,000-scale geologic map of part of the northern hemisphere of Venus included the V–6 map region and identified larger features such as tesserae, smooth and hummocky plains materials, ridge belts, coronae, volcanoes, and impact craters but proposed little relative-age information. Global-scale mapping from Magellan data identified similar features and also determined their mean global ages with crater counts. However, the density of craters on Venus is too low for meaningful relative-age determinations at local to regional scales. Several of the coronae in the map area have been described using Venera data (Stofan and Head, 1990), while Crumpler and others (1992) compiled detailed identification and description of volcanic and tectonic features from Magellan data. The main purpose of this map is to reconstruct the geologic history of the Metis Mons quadrangle at a level of detail commensurate with a scale of 1:5,000,000 using Magellan data. We interpret four partly overlapping stages of geologic activity, which collectively resulted in the formation of tesserae, coronae (oriented along structure belts), plains materials of varying ages, and four large volcanic constructs. Scattered impact craters, small shields and pancake-shaped domes, and isolated flows superpose the tectonically deformed materials and appear to be the most youthful materials in the map region.

SEGMENTATION OF MITOCHONDRIA IN ELECTRON MICROSCOPY IMAGES USING ALGEBRAIC CURVES.

PubMed

Seyedhosseini, Mojtaba; Ellisman, Mark H; Tasdizen, Tolga

2013-01-01

High-resolution microscopy techniques have been used to generate large volumes of data with enough details for understanding the complex structure of the nervous system. However, automatic techniques are required to segment cells and intracellular structures in these multi-terabyte datasets and make anatomical analysis possible on a large scale. We propose a fully automated method that exploits both shape information and regional statistics to segment irregularly shaped intracellular structures such as mitochondria in electron microscopy (EM) images. The main idea is to use algebraic curves to extract shape features together with texture features from image patches. Then, these powerful features are used to learn a random forest classifier, which can predict mitochondria locations precisely. Finally, the algebraic curves together with regional information are used to segment the mitochondria at the predicted locations. We demonstrate that our method outperforms the state-of-the-art algorithms in segmentation of mitochondria in EM images.

Automated Structural Optimization System (ASTROS). Volume 2. User’s Manual

DTIC Science & Technology

1988-04-07

preparation and on the use of advanced features that permit the user to modify the standard execution of ASTROS. f^Q^S*. ) I I J...software in considera- ble detail to direct the procedure to perform these alternative functions. The mechanisms by which these more advanced features are...grossly modify the existing capabilities of the system. These more advanced topics are treated in the Programmer’s and Application Manuals which

Nanoscale organization in the fluorinated room temperature ionic liquid: Tetraethyl ammonium (trifluoromethanesulfonyl)(nonafluorobutylsulfonyl)imide

NASA Astrophysics Data System (ADS)

Lo Celso, F.; Appetecchi, G. B.; Jafta, C. J.; Gontrani, L.; Canongia Lopes, J. N.; Triolo, A.; Russina, O.

2018-05-01

Fluorinated Room Temperature Ionic Liquids (FRTILs) are a branch of ionic liquids that is the object of growing interest for a wide range of potential applications, due to the synergic combination of specifically ionic features and those properties that stem from fluorous tails. So far limited experimental work exists on the micro- and mesoscopic structural organization in this class of compounds. Such a work is however necessary to fully understand morphological details at atomistic level that would have strong implications in terms of bulk properties. Here we use the synergy between X-ray and neutron scattering together with molecular dynamics simulations to access structural details of a technologically relevant FRTIL that is characterised by an anion bearing a long enough fluorinated tail to develop specific morphological features. In particular, we find the first experimental evidence that in FRTILs bearing an asymmetric bis(perfluoroalkyl)sulfonyl-imide anion, fluorous side chains tend to be spatially segregated into nm-scale spatial heterogeneities. This feature together with the well-established micro-segregation of side alkyl chains in conventional RTILs leads to the concept of triphilic ILs, whose technological applications are yet to be fully developed.

Laryngeal Features Are Phonetically Abstract: Mismatch Negativity Evidence from Arabic, English, and Russian

PubMed Central

Schluter, Kevin T.; Politzer-Ahles, Stephen; Al Kaabi, Meera; Almeida, Diogo

2017-01-01

Many theories of phonology assume that the sound structure of language is made up of distinctive features, but there is considerable debate about how much articulatory detail distinctive features encode in long-term memory. Laryngeal features such as voicing provide a unique window into this question: while many languages have two-way contrasts that can be given a simple binary feature account [±VOICE], the precise articulatory details underlying these contrasts can vary significantly across languages. Here, we investigate a series of two-way voicing contrasts in English, Arabic, and Russian, three languages that implement their voicing contrasts very differently at the articulatory-phonetic level. In three event-related potential experiments contrasting English, Arabic, and Russian fricatives along with Russian stops, we observe a consistent pattern of asymmetric mismatch negativity (MMN) effects that is compatible with an articulatorily abstract and cross-linguistically uniform way of marking two-way voicing contrasts, as opposed to an articulatorily precise and cross-linguistically diverse way of encoding them. Regardless of whether a language is theorized to encode [VOICE] over [SPREAD GLOTTIS], the data is consistent with a universal marking of the [SPREAD GLOTTIS] feature. PMID:28555118

An evaluation of the suitability of ERTS data for the purposes of petroleum exploration. [lithology and geological structure of Anadarko Basin of Oklahoma and Texas

NASA Technical Reports Server (NTRS)

Collins, R. J. (Principal Investigator); Mccown, F. P.; Stonis, L. P.; Petzel, G. J.; Everett, J. R.

1974-01-01

The author has identified the following significant results. ERTS-1 data give exploration geologists a new perspective for looking at the earth. The data are excellent for interpreting regional lithologic and structural relationships and quickly directing attention to areas of greatest exploration interest. Information derived from ERTS data useful for petroleum exploration include: linear features, general lithologic distribution, identification of various anomalous features, some details of structures controlling hydrocarbon accumulation, overall structural relationships, and the regional context of the exploration province. Many anomalies (particularly geomorphic anomalies) correlate with known features of petroleum exploration interest. Linears interpreted from the imagery that were checked in the field correlate with fractures. Bands 5 and 7 and color composite imagery acquired during the periods of maximum and minimum vegetation vigor are best for geologic interpretation. Preliminary analysis indicates that use of ERTS imagery can substantially reduce the cost of petroleum exploration in relatively unexplored areas.

High temperature arc-track resistant aerospace insulation

NASA Technical Reports Server (NTRS)

Dorogy, William

1994-01-01

The topics are presented in viewgraph form and include the following: high temperature aerospace insulation; Foster-Miller approach to develop a 300 C rated, arc-track resistant aerospace insulation; advantages and disadvantages of key structural features; summary goals and achievements of the phase 1 program; performance goals for selected materials; materials under evaluation; molecular structures of candidate polymers; candidate polymer properties; film properties; and a detailed program plan.

Broadband locally resonant metamaterials with graded hierarchical architecture

NASA Astrophysics Data System (ADS)

Liu, Chenchen; Reina, Celia

2018-03-01

We investigate the effect of hierarchical designs on the bandgap structure of periodic lattice systems with inner resonators. A detailed parameter study reveals various interesting features of structures with two levels of hierarchy as compared with one level systems with identical static mass. In particular: (i) their overall bandwidth is approximately equal, yet bounded above by the bandwidth of the single-resonator system; (ii) the number of bandgaps increases with the level of hierarchy; and (iii) the spectrum of bandgap frequencies is also enlarged. Taking advantage of these features, we propose graded hierarchical structures with ultra-broadband properties. These designs are validated over analogous continuum models via finite element simulations, demonstrating their capability to overcome the bandwidth narrowness that is typical of resonant metamaterials.

Theoretical and experimental studies of hyperreflective polymer-network cholesteric liquid crystal structures with helicity inversion

NASA Astrophysics Data System (ADS)

Tasolamprou, A. C.; Mitov, M.; Zografopoulos, D. C.; Kriezis, E. E.

2009-03-01

Single-layer cholesteric liquid crystals exhibit a reflection coefficient which is at most 50% for unpolarized incident light. We give theoretical and experimental evidence of single-layer polymer-stabilized cholesteric liquid-crystalline structures that demonstrate hyper-reflective properties. Such original features are derived by the concurrent and randomly interlaced presence of both helicities. The fundamental properties of such structures are revealed by detailed numerical simulations based on a stochastic approach.

Strike-Slip Faulting Processes on Ganymede: Global Morphological Mapping and Structural Interpretation of Grooved and Transitional Terrains

NASA Astrophysics Data System (ADS)

Burkhard, L. M.; Cameron, M. E.; Smith-Konter, B. R.; Seifert, F.; Pappalardo, R. T.; Collins, G. C.

2015-12-01

Ganymede's fractured surface reveals many large-scale, morphologically distinct regions of inferred distributed shear and strike-slip faulting that may be important to the structural development of its surface and in the transition from dark to light (grooved) materials. To better understand the role of strike-slip tectonism in shaping Ganymede's complex icy surface, we perform a detailed mapping of key examples of strike-slip morphologies (i.e., en echelon structures, strike-slip duplexes, laterally offset pre-existing features, and possible strained craters) from Galileo and Voyager images. We focus on complex structures associated with grooved terrain (e.g. Nun Sulcus, Dardanus Sulcus, Tiamat Sulcus, and Arbela Sulcus) and terrains transitional from dark to light terrain (e.g. the boundary between Nippur Sulcus and Marius Regio, including Byblus Sulcus and Philus Sulcus). Detailed structural interpretations suggest strong evidence of strike-slip faulting in some regions (i.e., Nun and Dardanus Sulcus); however, further investigation of additional strike-slip structures is required of less convincing regions (i.e., Byblus Sulcus). Where applicable, these results are synthesized into a global database representing an inferred sense of shear for many of Ganymede's fractures. Moreover, when combined with existing observations of extensional features, these results help to narrow down the range of possible principal stress directions that could have acted at the regional or global scale to produce grooved terrain on Ganymede.

Structural and Mechanistic Insights into C-P Bond Hydrolysis by Phosphonoacetate Hydrolase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agarwal, Vinayak; Borisova, Svetlana A.; Metcalf, William W.

2011-12-22

Bacteria have evolved pathways to metabolize phosphonates as a nutrient source for phosphorus. In Sinorhizobium meliloti 1021, 2-aminoethylphosphonate is catabolized to phosphonoacetate, which is converted to acetate and inorganic phosphate by phosphonoacetate hydrolase (PhnA). Here we present detailed biochemical and structural characterization of PhnA that provides insights into the mechanism of C-P bond cleavage. The 1.35 {angstrom} resolution crystal structure reveals a catalytic core similar to those of alkaline phosphatases and nucleotide pyrophosphatases but with notable differences, such as a longer metal-metal distance. Detailed structure-guided analysis of active site residues and four additional cocrystal structures with phosphonoacetate substrate, acetate, phosphonoformatemore » inhibitor, and a covalently bound transition state mimic provide insight into active site features that may facilitate cleavage of the C-P bond. These studies expand upon the array of reactions that can be catalyzed by enzymes of the alkaline phosphatase superfamily.« less

ScrumPy: metabolic modelling with Python.

PubMed

Poolman, M G

2006-09-01

ScrumPy is a software package used for the definition and analysis of metabolic models. It is written using the Python programming language that is also used as a user interface. ScrumPy has features for both kinetic and structural modelling, but the emphasis is on structural modelling and those features of most relevance to analysis of large (genome-scale) models. The aim is at describing ScrumPy's functionality to readers with some knowledge of metabolic modelling, but implementation, programming and other computational details are omitted. ScrumPy is released under the Gnu Public Licence, and available for download from http://mudshark.brookes.ac.uk/ ScrumPy.

Progressive Fracture of Composite Structures

NASA Technical Reports Server (NTRS)

Minnetyan, Levon

2001-01-01

This report includes the results of a research in which the COmposite Durability STRuctural ANalysis (CODSTRAN) computational simulation capabilities were augmented and applied to various structures for demonstration of the new features and verification. The first chapter of this report provides an introduction to the computational simulation or virtual laboratory approach for the assessment of damage and fracture progression characteristics in composite structures. The second chapter outlines the details of the overall methodology used, including the failure criteria and the incremental/iterative loading procedure with the definitions of damage, fracture, and equilibrium states. The subsequent chapters each contain an augmented feature of the code and/or demonstration examples. All but one of the presented examples contains laminated composite structures with various fiber/matrix constituents. For each structure simulated, damage initiation and progression mechanisms are identified and the structural damage tolerance is quantified at various degradation stages. Many chapters contain the simulation of defective and defect free structures to evaluate the effects of existing defects on structural durability.

Integrating prior information into microwave tomography Part 1: Impact of detail on image quality.

PubMed

Kurrant, Douglas; Baran, Anastasia; LoVetri, Joe; Fear, Elise

2017-12-01

The authors investigate the impact that incremental increases in the level of detail of patient-specific prior information have on image quality and the convergence behavior of an inversion algorithm in the context of near-field microwave breast imaging. A methodology is presented that uses image quality measures to characterize the ability of the algorithm to reconstruct both internal structures and lesions embedded in fibroglandular tissue. The approach permits key aspects that impact the quality of reconstruction of these structures to be identified and quantified. This provides insight into opportunities to improve image reconstruction performance. Patient-specific information is acquired using radar-based methods that form a regional map of the breast. This map is then incorporated into a microwave tomography algorithm. Previous investigations have demonstrated the effectiveness of this approach to improve image quality when applied to data generated with two-dimensional (2D) numerical models. The present study extends this work by generating prior information that is customized to vary the degree of structural detail to facilitate the investigation of the role of prior information in image formation. Numerical 2D breast models constructed from magnetic resonance (MR) scans, and reconstructions formed with a three-dimensional (3D) numerical breast model are used to assess if trends observed for the 2D results can be extended to 3D scenarios. For the blind reconstruction scenario (i.e., no prior information), the breast surface is not accurately identified and internal structures are not clearly resolved. A substantial improvement in image quality is achieved by incorporating the skin surface map and constraining the imaging domain to the breast. Internal features within the breast appear in the reconstructed image. However, it is challenging to discriminate between adipose and glandular regions and there are inaccuracies in both the structural properties of the glandular region and the dielectric properties reconstructed within this structure. Using a regional map with a skin layer only marginally improves this situation. Increasing the structural detail in the prior information to include internal features leads to reconstructions for which the interface that delineates the fat and gland regions can be inferred. Different features within the glandular region corresponding to tissues with varying relative permittivity values, such as a lesion embedded within glandular structure, emerge in the reconstructed images. Including knowledge of the breast surface and skin layer leads to a substantial improvement in image quality compared to the blind case, but the images have limited diagnostic utility for applications such as tumor response tracking. The diagnostic utility of the reconstruction technique is improved considerably when patient-specific structural information is used. This qualitative observation is supported quantitatively with image metrics. © 2017 American Association of Physicists in Medicine.

Mimas: Tectonic structure and geologic history

NASA Technical Reports Server (NTRS)

Croft, Steven K.

1991-01-01

Mimas, the innermost of the major saturnian satellites, occupies an important place in comparative studies of icy satellites. It is the smallest icy satellite known to have a mostly spherical shape. Smaller icy objects like Hyperion and Puck are generally irregular in shape, while larger ones like Miranda and Enceladus are spherical. Thus Mimas is near the diameter where the combination of increasing surface gravity and internal heating begin to have a significant effect on global structure. The nature and extent of endogenic surface features provide important constraints on the interior structure and history of this transitional body. The major landforms on Mimas are impact craters. Mimas has one of the most heavily cratered surfaces in the solar system. The most prominent single feature on Mimas is Herschel, an unrelaxed complex crater 130 km in diameter. The only other recognized landforms on Mimas are tectonic grooves and lineaments. Groove locations were mapped by Schenk, but without analysis of groove structures or superposition relationships. Mimas' tectonic structures are remapped here in more detail than previously has been done, as part of a general study of tectonic features on icy satellites.

METAShield: Hot Metallic Aeroshell Concept for RLV/SOV

NASA Technical Reports Server (NTRS)

Scotti, Stephen J.; Poteet, Carl C.; Daryabeigi, Kamran; Nowak, Robert J.; Hsu, Su-Yuen; Schmidt, Irvin H.; Ku, Shih-Huei P.

2003-01-01

An innovative fuselage design approach that combines many desirable operational features with a simple and efficient structural approach is being developed by NASA. The approach, named METAShield for MEtallic TransAtmospheric Shield, utilizes lightly loaded, hot aeroshell structures surrounding integral propellant tanks that carry the primary structural loads. The aeroshells are designed to withstand the local pressure loads, transmitting them to the tanks with minimal restraint of thermal growth. No additional thermal protection system protects the METAShield, and a fibrous or multilayer insulation blanket, located in the space between the aeroshell and the tanks, serves as both high temperature and cryogenic insulation for the tanks. The concept is described in detail, and the performance and operational features are highlighted. Initial design results and analyses of the structural, thermal, and thermal-structural performance are described. Computational results evaluating resistance to hypervelocity impact damage, as well as some supporting aerothermal wind tunnel results. are also presented. Future development needs are summarized.

Structurally detailed coarse-grained model for Sec-facilitated co-translational protein translocation and membrane integration

PubMed Central

Miller, Thomas F.

2017-01-01

We present a coarse-grained simulation model that is capable of simulating the minute-timescale dynamics of protein translocation and membrane integration via the Sec translocon, while retaining sufficient chemical and structural detail to capture many of the sequence-specific interactions that drive these processes. The model includes accurate geometric representations of the ribosome and Sec translocon, obtained directly from experimental structures, and interactions parameterized from nearly 200 μs of residue-based coarse-grained molecular dynamics simulations. A protocol for mapping amino-acid sequences to coarse-grained beads enables the direct simulation of trajectories for the co-translational insertion of arbitrary polypeptide sequences into the Sec translocon. The model reproduces experimentally observed features of membrane protein integration, including the efficiency with which polypeptide domains integrate into the membrane, the variation in integration efficiency upon single amino-acid mutations, and the orientation of transmembrane domains. The central advantage of the model is that it connects sequence-level protein features to biological observables and timescales, enabling direct simulation for the mechanistic analysis of co-translational integration and for the engineering of membrane proteins with enhanced membrane integration efficiency. PMID:28328943

TRANSAT-- method for detecting the conserved helices of functional RNA structures, including transient, pseudo-knotted and alternative structures.

PubMed

Wiebe, Nicholas J P; Meyer, Irmtraud M

2010-06-24

The prediction of functional RNA structures has attracted increased interest, as it allows us to study the potential functional roles of many genes. RNA structure prediction methods, however, assume that there is a unique functional RNA structure and also do not predict functional features required for in vivo folding. In order to understand how functional RNA structures form in vivo, we require sophisticated experiments or reliable prediction methods. So far, there exist only a few, experimentally validated transient RNA structures. On the computational side, there exist several computer programs which aim to predict the co-transcriptional folding pathway in vivo, but these make a range of simplifying assumptions and do not capture all features known to influence RNA folding in vivo. We want to investigate if evolutionarily related RNA genes fold in a similar way in vivo. To this end, we have developed a new computational method, Transat, which detects conserved helices of high statistical significance. We introduce the method, present a comprehensive performance evaluation and show that Transat is able to predict the structural features of known reference structures including pseudo-knotted ones as well as those of known alternative structural configurations. Transat can also identify unstructured sub-sequences bound by other molecules and provides evidence for new helices which may define folding pathways, supporting the notion that homologous RNA sequence not only assume a similar reference RNA structure, but also fold similarly. Finally, we show that the structural features predicted by Transat differ from those assuming thermodynamic equilibrium. Unlike the existing methods for predicting folding pathways, our method works in a comparative way. This has the disadvantage of not being able to predict features as function of time, but has the considerable advantage of highlighting conserved features and of not requiring a detailed knowledge of the cellular environment.

LS-SNP/PDB: annotated non-synonymous SNPs mapped to Protein Data Bank structures.

PubMed

Ryan, Michael; Diekhans, Mark; Lien, Stephanie; Liu, Yun; Karchin, Rachel

2009-06-01

LS-SNP/PDB is a new WWW resource for genome-wide annotation of human non-synonymous (amino acid changing) SNPs. It serves high-quality protein graphics rendered with UCSF Chimera molecular visualization software. The system is kept up-to-date by an automated, high-throughput build pipeline that systematically maps human nsSNPs onto Protein Data Bank structures and annotates several biologically relevant features. LS-SNP/PDB is available at (http://ls-snp.icm.jhu.edu/ls-snp-pdb) and via links from protein data bank (PDB) biology and chemistry tabs, UCSC Genome Browser Gene Details and SNP Details pages and PharmGKB Gene Variants Downloads/Cross-References pages.

A Guide for Planning Indoor Facilities for College Physical Education.

ERIC Educational Resources Information Center

Crawford, Wayne H.

Following a general consideration of the functional aspects of planning facilities and the relationship between program and facilities, a detailed presentation is made of planning buildings for college and university indoor physical education activities. Recommendations are made with regard to design, structural and functional features of…

Network Interface Specification for the T1 Microprocessor

DTIC Science & Technology

1994-05-01

features data transfer directly to/from processor registers, hardware dispatch directly to Active Message handlers (along with limited context...Implementation Choices 9 3.1 Overview .................................... 9 3.2 Context ..................................... 10 3.3 Data Transfer...details of the data transfer functional units, interconnect structure, and network operation. Application Layer Communication Model Communication

Thermal infrared emission spectroscopy of the pyroxene mineral series

NASA Astrophysics Data System (ADS)

Hamilton, Victoria E.

2000-04-01

The thermal infrared emissivity spectra of coarse particulate samples of compositions in the pyroxene series display reststrahlen features (absorptions) that distinguish not only orthorhombic from monoclinic structures, but also major end-members within the two structural groups, as well as minerals within solid solution series. The exact number of reststrahlen features observed and their positions are dependent on mineral structure and cation occupancy of the M1 and M2 sites. End-member quadrilateral pyroxenes (Mg2Si2O6-Fe2Si2O6-Ca[Mg,Fe]Si2O6) are easily distinguished from each other and from minerals in the nonquadrilateral series (NaFeSi2O6-Na[Al,Fe]Si2O6-LiAlSi2O6). Furthermore, among quadrilateral pyroxenes, variations in Mg/(Mg+Fe) are linearly correlated with several band locations, as are variations in Ca content in high-Ca clinopyroxenes. In both quadrilateral and nonquadrilateral compositions, Christiansen feature positions are also diagnostic. No correlations with minor constituents (of the order of 0.05 atoms per formula unit) were observed. The detailed spectral characteristics of pyroxenes and their variability as a function of structure and cation occupancy are presented here with determinative curves for the identification of pyroxene composition. These data have important implications for the interpretation of spectral data from both laboratory and remote sensing instruments because they should permit a more detailed determination of pyroxene composition in measured unknown pure mineral and bulk compositions dominated by surface scattering, i.e., all particulates greater than ~65 μm, and solid samples.

A close-range photogrammetric technique for mapping neotectonic features in trenches

USGS Publications Warehouse

Fairer, G.M.; Whitney, J.W.; Coe, J.A.

1989-01-01

Close-range photogrammetric techniques and newly available computerized plotting equipment were used to map exploratory trench walls that expose Quaternary faults in the vicinity of Yucca Mountain, Nevada. Small-scale structural, lithologic, and stratigraphic features can be rapidly mapped by the photogrammetric method. This method is more accurate and significantly more rapid than conventional trench-mapping methods, and the analytical plotter is capable of producing cartographic definition of high resolution when detailed trench maps are necessary. -from Authors

Elemental and Microscopic Analysis of Naturally Occurring C-O-Si Hetero-Fullerene-Like Structures.

PubMed

Hullavarad, Nilima V; Hullavarad, Shiva S; Fochesatto, Javier

2015-03-01

Carbon exhibits an ability to form a wide range of structures in nature. Under favorable conditions, carbon condenses to form hollow, spheroid fullerenes in an inert atmosphere. Using high resolution FESEM, we have concealed the existence of giant hetero-fullerene like structures in the natural form. Clear, distinct features of connected hexagons and pentagons were observed. Energy dispersive X-ray analysis depth-profile of natural fullerene structures indicates that Russian-doll-like configurations composed of C, 0, and Si rings exist in nature. The analysis is based on an outstanding molecular feature found in the size fraction of aerosols having diameters 150 nm to 1.0 µm. The fullerene like structures, which are ~ 150 nm in diameter, are observed in large numbers. To the best of our knowledge, this is the first direct detailed observation of natural fullerene-like structures. This article reports inadvertent observation of naturally occurring hetero-fullerene-like structures in the Arctic.

Vehicle license plate recognition based on geometry restraints and multi-feature decision

NASA Astrophysics Data System (ADS)

Wu, Jianwei; Wang, Zongyue

2005-10-01

Vehicle license plate (VLP) recognition is of great importance to many traffic applications. Though researchers have paid much attention to VLP recognition there has not been a fully operational VLP recognition system yet for many reasons. This paper discusses a valid and practical method for vehicle license plate recognition based on geometry restraints and multi-feature decision including statistical and structural features. In general, the VLP recognition includes the following steps: the location of VLP, character segmentation, and character recognition. This paper discusses the three steps in detail. The characters of VLP are always declining caused by many factors, which makes it more difficult to recognize the characters of VLP, therefore geometry restraints such as the general ratio of length and width, the adjacent edges being perpendicular are used for incline correction. Image Moment has been proved to be invariant to translation, rotation and scaling therefore image moment is used as one feature for character recognition. Stroke is the basic element for writing and hence taking it as a feature is helpful to character recognition. Finally we take the image moment, the strokes and the numbers of each stroke for each character image and some other structural features and statistical features as the multi-feature to match each character image with sample character images so that each character image can be recognized by BP neural net. The proposed method combines statistical and structural features for VLP recognition, and the result shows its validity and efficiency.

Dynamic Relaxation: A Technique for Detailed Thermo-Elastic Structural Analysis of Transportation Structures

NASA Astrophysics Data System (ADS)

Shoukry, Samir N.; William, Gergis W.; Riad, Mourad Y.; McBride, Kevyn C.

2006-08-01

Dynamic relaxation is a technique developed to solve static problems through an explicit integration in finite element. The main advantage of such a technique is the ability to solve a large problem in a relatively short time compared with the traditional implicit techniques, especially when using nonlinear material models. This paper describes the use of such a technique in analyzing large transportation structures as dowel jointed concrete pavements and 306-m-long, reinforced concrete bridge superstructure under the effect of temperature variations. The main feature of the pavement model is the detailed modeling of dowel bars and their interfaces with the surrounding concrete using extremely fine mesh of solid elements, while in the bridge structure it is the detailed modeling of the girder-deck interface as well as the bracing members between the girders. The 3DFE results were found to be in a good agreement with experimentally measured data obtained from an instrumented pavements sections and a highway bridge constructed in West Virginia. Thus, such a technique provides a good tool for analyzing the response of large structures to static loads in a fraction of the time required by traditional, implicit finite element methods.

Evaluation of ERTS-1 data applications to geologic mapping, structural analysis and mineral resource inventory of South America with special emphasis on the Andes Mountain region. [Bolivia, Chile, and Peru

NASA Technical Reports Server (NTRS)

Carter, W. D. (Principal Investigator)

1974-01-01

The author has identified the following significant results. The La Paz Mosaic and its attendant overlays serve as a model for geologic studies elsewhere in the world. The P.I. and two geologists are mapping the conterminous states at scales of 1:5000,000 and 1:1,000,000. The 1:5 million band 5 mosaic was completed in two days of analysis. The 1:1 million band sheets are being completed at the rate of one per day. Comparison of the preliminary results of the three investigators shows a high correlation of linear and curvilinear features. Comparison with magnetic and gravity data indicates that many features being mapped are deep seated structures that have been active through long periods of geologic time, perhaps dating back to the Precambrian period. A detailed analysis of the El Salvador mining district has been completed. The interpretation is extremely detailed showing a complex pattern of linear features and bedrock outcrop patterns. This is the first product from ERTS-1 to be provided by Chile and shows a high degree of expertise in image interpretation. The Chileans are enthusiastic about their results and are anxious to map the entire country using ERTS.

Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.

PubMed

Sangwan, Smriti; Sawaya, Michael R; Murray, Kevin A; Hughes, Michael P; Eisenberg, David S

2018-02-17

The aggregation cascade of disease-related amyloidogenic proteins, terminating in insoluble amyloid fibrils, involves intermediate oligomeric states. The structural and biochemical details of these oligomers have been largely unknown. Here we report crystal structures of variants of the cytotoxic oligomer-forming segment residues 28-38 of the ALS-linked protein, SOD1. The crystal structures reveal three different architectures: corkscrew oligomeric structure, nontwisting curved sheet structure and a steric zipper proto-filament structure. Our work highlights the polymorphism of the segment 28-38 of SOD1 and identifies the molecular features of amyloidogenic entities. © 2018 The Protein Society.

Quantifying the Hierarchical Order in Self-Aligned Carbon Nanotubes from Atomic to Micrometer Scale.

PubMed

Meshot, Eric R; Zwissler, Darwin W; Bui, Ngoc; Kuykendall, Tevye R; Wang, Cheng; Hexemer, Alexander; Wu, Kuang Jen J; Fornasiero, Francesco

2017-06-27

Fundamental understanding of structure-property relationships in hierarchically organized nanostructures is crucial for the development of new functionality, yet quantifying structure across multiple length scales is challenging. In this work, we used nondestructive X-ray scattering to quantitatively map the multiscale structure of hierarchically self-organized carbon nanotube (CNT) "forests" across 4 orders of magnitude in length scale, from 2.0 Å to 1.5 μm. Fully resolved structural features include the graphitic honeycomb lattice and interlayer walls (atomic), CNT diameter (nano), as well as the greater CNT ensemble (meso) and large corrugations (micro). Correlating orientational order across hierarchical levels revealed a cascading decrease as we probed finer structural feature sizes with enhanced sensitivity to small-scale disorder. Furthermore, we established qualitative relationships for single-, few-, and multiwall CNT forest characteristics, showing that multiscale orientational order is directly correlated with number density spanning 10 9 -10 12 cm -2 , yet order is inversely proportional to CNT diameter, number of walls, and atomic defects. Lastly, we captured and quantified ultralow-q meridional scattering features and built a phenomenological model of the large-scale CNT forest morphology, which predicted and confirmed that these features arise due to microscale corrugations along the vertical forest direction. Providing detailed structural information at multiple length scales is important for design and synthesis of CNT materials as well as other hierarchically organized nanostructures.

HDlive rendering images of the fetal stomach: a preliminary report.

PubMed

Inubashiri, Eisuke; Abe, Kiyotaka; Watanabe, Yukio; Akutagawa, Noriyuki; Kuroki, Katumaru; Sugawara, Masaki; Maeda, Nobuhiko; Minami, Kunihiro; Nomura, Yasuhiro

2015-01-01

This study aimed to show reconstruction of the fetal stomach using the HDlive rendering mode in ultrasound. Seventeen healthy singleton fetuses at 18-34 weeks' gestational age were observed using the HDlive rendering mode of ultrasound in utero. In all of the fetuses, we identified specific spatial structures, including macroscopic anatomical features (e.g., the pyrous, cardia, fundus, and great curvature) of the fetal stomach, using the HDlive rendering mode. In particular, HDlive rendering images showed remarkably fine details that appeared as if they were being viewed under an endoscope, with visible rugal folds after 27 weeks' gestational age. Our study suggests that the HDlive rendering mode can be used as an additional method for evaluating the fetal stomach. The HDlive rendering mode shows detailed 3D structural images and anatomically realistic images of the fetal stomach. This technique may be effective in prenatal diagnosis for examining detailed information of fetal organs.

Pathways towards instability in financial networks

NASA Astrophysics Data System (ADS)

Bardoscia, Marco; Battiston, Stefano; Caccioli, Fabio; Caldarelli, Guido

2017-02-01

Following the financial crisis of 2007-2008, a deep analogy between the origins of instability in financial systems and complex ecosystems has been pointed out: in both cases, topological features of network structures influence how easily distress can spread within the system. However, in financial network models, the details of how financial institutions interact typically play a decisive role, and a general understanding of precisely how network topology creates instability remains lacking. Here we show how processes that are widely believed to stabilize the financial system, that is, market integration and diversification, can actually drive it towards instability, as they contribute to create cyclical structures which tend to amplify financial distress, thereby undermining systemic stability and making large crises more likely. This result holds irrespective of the details of how institutions interact, showing that policy-relevant analysis of the factors affecting financial stability can be carried out while abstracting away from such details.

Pathways towards instability in financial networks

PubMed Central

Bardoscia, Marco; Battiston, Stefano; Caccioli, Fabio; Caldarelli, Guido

2017-01-01

Following the financial crisis of 2007–2008, a deep analogy between the origins of instability in financial systems and complex ecosystems has been pointed out: in both cases, topological features of network structures influence how easily distress can spread within the system. However, in financial network models, the details of how financial institutions interact typically play a decisive role, and a general understanding of precisely how network topology creates instability remains lacking. Here we show how processes that are widely believed to stabilize the financial system, that is, market integration and diversification, can actually drive it towards instability, as they contribute to create cyclical structures which tend to amplify financial distress, thereby undermining systemic stability and making large crises more likely. This result holds irrespective of the details of how institutions interact, showing that policy-relevant analysis of the factors affecting financial stability can be carried out while abstracting away from such details. PMID:28221338

Beyond textbook illustrations: Hand-held models of ordered DNA and protein structures as 3D supplements to enhance student learning of helical biopolymers.

PubMed

Jittivadhna, Karnyupha; Ruenwongsa, Pintip; Panijpan, Bhinyo

2010-11-01

Textbook illustrations of 3D biopolymers on printed paper, regardless of how detailed and colorful, suffer from its two-dimensionality. For beginners, computer screen display of skeletal models of biopolymers and their animation usually does not provide the at-a-glance 3D perception and details, which can be done by good hand-held models. Here, we report a study on how our students learned more from using our ordered DNA and protein models assembled from colored computer-printouts on transparency film sheets that have useful structural details. Our models (reported in BAMBED 2009), having certain distinguished features, helped our students to grasp various aspects of these biopolymers that they usually find difficult. Quantitative and qualitative learning data from this study are reported. Copyright © 2010 International Union of Biochemistry and Molecular Biology, Inc.

Pathways towards instability in financial networks.

PubMed

Bardoscia, Marco; Battiston, Stefano; Caccioli, Fabio; Caldarelli, Guido

2017-02-21

Following the financial crisis of 2007-2008, a deep analogy between the origins of instability in financial systems and complex ecosystems has been pointed out: in both cases, topological features of network structures influence how easily distress can spread within the system. However, in financial network models, the details of how financial institutions interact typically play a decisive role, and a general understanding of precisely how network topology creates instability remains lacking. Here we show how processes that are widely believed to stabilize the financial system, that is, market integration and diversification, can actually drive it towards instability, as they contribute to create cyclical structures which tend to amplify financial distress, thereby undermining systemic stability and making large crises more likely. This result holds irrespective of the details of how institutions interact, showing that policy-relevant analysis of the factors affecting financial stability can be carried out while abstracting away from such details.

Intelligent Multi-scale Sensors for Damage Identification and Mitigation in Woven Composites for Aerospace Structural Applications

DTIC Science & Technology

2012-08-15

Bragg grating ( FBG ) sensors within these composite structures allows one to correlate sensor response features to “critical damage events” within the...material. The unique capabilities of this identification strategy are due to the detailed information obtained from the FBG sensors and the... FBG sensors relate to damage states not merely strain amplitudes. The research objectives of this project were therefore to:  demonstrate FBG

Dark mammoth trunks in the merging galaxy NGC 1316 and a mechanism of cosmic double helices

NASA Astrophysics Data System (ADS)

Carlqvist, Per

2010-06-01

NGC 1316 is a giant, elliptical galaxy containing a complex network of dark, dust features. The morphology of these features has been examined in some detail using a Hubble Space Telescope, Advanced Camera for Surveys image. It is found that most of the features are constituted of long filaments. There also exist a great number of dark structures protruding inwards from the filaments. Many of these structures are strikingly similar to elephant trunks in H ii regions in the Milky Way Galaxy, although much larger. The structures, termed mammoth trunks, generally are filamentary and often have shapes resembling the letters V or Y. In some of the mammoth trunks the stem of the Y can be resolved into two or more filaments, many of which showing signs of being intertwined. A model of the mammoth trunks, related to a recent theory of elephant trunks, is proposed. Based on magnetized filaments, the model is capable of giving an account of the various shapes of the mammoth trunks observed, including the twined structures.

Absence of auditory 'global interference' in autism.

PubMed

Foxton, Jessica M; Stewart, Mary E; Barnard, Louise; Rodgers, Jacqui; Young, Allan H; O'Brien, Gregory; Griffiths, Timothy D

2003-12-01

There has been considerable recent interest in the cognitive style of individuals with Autism Spectrum Disorder (ASD). One theory, that of weak central coherence, concerns an inability to combine stimulus details into a coherent whole. Here we test this theory in the case of sound patterns, using a new definition of the details (local structure) and the coherent whole (global structure). Thirteen individuals with a diagnosis of autism or Asperger's syndrome and 15 control participants were administered auditory tests, where they were required to match local pitch direction changes between two auditory sequences. When the other local features of the sequence pairs were altered (the actual pitches and relative time points of pitch direction change), the control participants obtained lower scores compared with when these details were left unchanged. This can be attributed to interference from the global structure, defined as the combination of the local auditory details. In contrast, the participants with ASD did not obtain lower scores in the presence of such mismatches. This was attributed to the absence of interference from an auditory coherent whole. The results are consistent with the presence of abnormal interactions between local and global auditory perception in ASD.

Imposed, ordered dust structures and other plasma features in a strongly magnetized plasma

NASA Astrophysics Data System (ADS)

Thomas, Edward; Leblanc, Spencer; Lynch, Brian; Konopka, Uwe; Merlino, Robert; Rosenberg, Marlene

2015-11-01

The Magnetized Dusty Plasma Experiment (MDPX) device has been in operation for just over one year. In that time, the MDPX device has been operating using a uniform magnetic field configuration up to 3.0 Tesla and has successfully produced plasmas and dusty plasmas at high magnetic fields. In these experimental studies, we have made observations of a new type of imposed, ordered structure in a dusty plasma at magnetic fields above 1 T. These dusty plasma structures are shown to scale inversely with neutral pressure and are shown to reflect the spatial structure of a wire mesh placed in the plasma. Additionally, recent measurements have been made that give insights into the effective potential that establishes the ordered structures in the plasma. In this presentation, we report on details of the imposed, ordered dusty plasma structure as well as filamentary features that also appear in the plasma and modify the confinement of the dusty plasma. This work is supported with funding from the NSF and Department of Energy.

Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif*

PubMed Central

Siponen, Marina I.; Wisniewska, Magdalena; Lehtiö, Lari; Johansson, Ida; Svensson, Linda; Raszewski, Grzegorz; Nilsson, Lennart; Sigvardsson, Mikael; Berglund, Helena

2010-01-01

The early B-cell factor (EBF) transcription factors are central regulators of development in several organs and tissues. This protein family shows low sequence similarity to other protein families, which is why structural information for the functional domains of these proteins is crucial to understand their biochemical features. We have used a modular approach to determine the crystal structures of the structured domains in the EBF family. The DNA binding domain reveals a striking resemblance to the DNA binding domains of the Rel homology superfamily of transcription factors but contains a unique zinc binding structure, termed zinc knuckle. Further the EBF proteins contain an IPT/TIG domain and an atypical helix-loop-helix domain with a novel type of dimerization motif. The data presented here provide insights into unique structural features of the EBF proteins and open possibilities for detailed molecular investigations of this important transcription factor family. PMID:20592035

[Analysis of Conformational Features of Watson-Crick Duplex Fragments by Molecular Mechanics and Quantum Mechanics Methods].

PubMed

Poltev, V I; Anisimov, V M; Sanchez, C; Deriabina, A; Gonzalez, E; Garcia, D; Rivas, F; Polteva, N A

2016-01-01

It is generally accepted that the important characteristic features of the Watson-Crick duplex originate from the molecular structure of its subunits. However, it still remains to elucidate what properties of each subunit are responsible for the significant characteristic features of the DNA structure. The computations of desoxydinucleoside monophosphates complexes with Na-ions using density functional theory revealed a pivotal role of DNA conformational properties of single-chain minimal fragments in the development of unique features of the Watson-Crick duplex. We found that directionality of the sugar-phosphate backbone and the preferable ranges of its torsion angles, combined with the difference between purines and pyrimidines. in ring bases, define the dependence of three-dimensional structure of the Watson-Crick duplex on nucleotide base sequence. In this work, we extended these density functional theory computations to the minimal' fragments of DNA duplex, complementary desoxydinucleoside monophosphates complexes with Na-ions. Using several computational methods and various functionals, we performed a search for energy minima of BI-conformation for complementary desoxydinucleoside monophosphates complexes with different nucleoside sequences. Two sequences are optimized using ab initio method at the MP2/6-31++G** level of theory. The analysis of torsion angles, sugar ring puckering and mutual base positions of optimized structures demonstrates that the conformational characteristic features of complementary desoxydinucleoside monophosphates complexes with Na-ions remain within BI ranges and become closer to the corresponding characteristic features of the Watson-Crick duplex crystals. Qualitatively, the main characteristic features of each studied complementary desoxydinucleoside monophosphates complex remain invariant when different computational methods are used, although the quantitative values of some conformational parameters could vary lying within the limits typical for the corresponding family. We observe that popular functionals in density functional theory calculations lead to the overestimated distances between base pairs, while MP2 computations and the newer complex functionals produce the structures that have too close atom-atom contacts. A detailed study of some complementary desoxydinucleoside monophosphate complexes with Na-ions highlights the existence of several energy minima corresponding to BI-conformations, in other words, the complexity of the relief pattern of the potential energy surface of complementary desoxydinucleoside monophosphate complexes. This accounts for variability of conformational parameters of duplex fragments with the same base sequence. Popular molecular mechanics force fields AMBER and CHARMM reproduce most of the conformational characteristics of desoxydinucleoside monophosphates and their complementary complexes with Na-ions but fail to reproduce some details of the dependence of the Watson-Crick duplex conformation on the nucleotide sequence.

Digitally enhanced GLORIA images for petroleum exploration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prindle, R.O.; Lanz, K

1990-05-01

This poster presentation graphically depicts the geological and structural information that can be derived from digitally enhanced Geological Long Range Inclined Asdic (GLORIA) sonar images. This presentation illustrates the advantages of scale enlargement as an interpreter's tool in an offshore area within the Eel River Basin, Northern California. Sonographs were produced from digital tapes originally collected for the exclusive economic zone (EEZ)-SCAN 1984 survey, which was published in the Atlas of the Western Conterminous US at a scale of 1:500,000. This scale is suitable for displaying regional offshore tectonic features but does not have the resolution required for detailed geologicalmore » mapping necessary for petroleum exploration. Applications of digital enhancing techniques which utilize contrast stretching and assign false colors to wide-swath sonar imagery (approximately 40 km) with 50-m resolution enables the acquisition and interpretation of significantly more geological and structural data. This, combined with a scale enlargement to 1:100,000 and high contrast contact prints vs. the offset prints of the atlas, increases the resolution and sharpness of bathymetric features so that many more subtle features may be mapped in detail. A tectonic interpretation of these digitally enhanced GLORIA sonographs from the Eel River basin is presented, displaying anticlines, lineaments, ridge axis, pathways of sediment flow, and subtle doming. Many of these features are not present on published bathymetric maps and have not been derived from seismic data because the plan view spatial resolution is much less than that available from the GLORIA imagery.« less

Advanced Metallic Thermal Protection System Development

NASA Technical Reports Server (NTRS)

Blosser, M. L.; Chen, R. R.; Schmidt, I. H.; Dorsey, J. T.; Poteet, C. C.; Bird, R. K.

2002-01-01

A new Adaptable, Robust, Metallic, Operable, Reusable (ARMOR) thermal protection system (TPS) concept has been designed, analyzed, and fabricated. In addition to the inherent tailorable robustness of metallic TPS, ARMOR TPS offers improved features based on lessons learned from previous metallic TPS development efforts. A specific location on a single-stage-to-orbit reusable launch vehicle was selected to develop loads and requirements needed to design prototype ARMOR TPS panels. The design loads include ascent and entry heating rate histories, pressures, acoustics, and accelerations. Additional TPS design issues were identified and discussed. An iterative sizing procedure was used to size the ARMOR TPS panels for thermal and structural loads as part of an integrated TPS/cryogenic tank structural wall. The TPS panels were sized to maintain acceptable temperatures on the underlying structure and to operate under the design structural loading. Detailed creep analyses were also performed on critical components of the ARMOR TPS panels. A lightweight, thermally compliant TPS support system (TPSS) was designed to connect the TPS to the cryogenic tank structure. Four 18-inch-square ARMOR TPS panels were fabricated. Details of the fabrication process are presented. Details of the TPSS for connecting the ARMOR TPS panels to the externally stiffened cryogenic tank structure are also described. Test plans for the fabricated hardware are presented.

Before Five: Early Childhood Care and Education in New Zealand.

ERIC Educational Resources Information Center

New Zealand Dept. of Education, Wellington.

This publication outlines the Government of New Zealand's new plans and policies for the administration of early childhood care and education. Specific features are discussed in detail in sections concerning: (1) early childhood care and education at the local level, specifically management structures and responsibilities, the use of Crown land,…

Meteoroid and debris special investigation group data acquisition procedures

NASA Technical Reports Server (NTRS)

See, Thomas H.; Allbrooks, Martha K.; Atkinson, Dale R.; Sapp, Clyde A.; Simon, Charles G.; Zolensky, Mike E.

1992-01-01

The entire LDEF spacecraft was examined by M&D SIG for impact (i.e., craters greater than or = 0.5 mm and penetrations greater than or = 0.3 mm in diameter) and related features (e.g., debris, secondaries). During the various detailed surveys conducted at NASA Kennedy, approx. 5,000 impact related features were photodocumented, and their locations measured and recorded; an additional approx. 30,000 smaller features were counted. The equipment and techniques used by the M&D SIG permitted the determination and recording of the locations and diameters of the 5,000 imaged features. A variety of experimental and LDEF structural hardware was acquired by the M&D SIG and is presently being examined and curated at NASA Johnson.

Computer-aided diagnosis for phase-contrast X-ray computed tomography: quantitative characterization of human patellar cartilage with high-dimensional geometric features.

PubMed

Nagarajan, Mahesh B; Coan, Paola; Huber, Markus B; Diemoz, Paul C; Glaser, Christian; Wismüller, Axel

2014-02-01

Phase-contrast computed tomography (PCI-CT) has shown tremendous potential as an imaging modality for visualizing human cartilage with high spatial resolution. Previous studies have demonstrated the ability of PCI-CT to visualize (1) structural details of the human patellar cartilage matrix and (2) changes to chondrocyte organization induced by osteoarthritis. This study investigates the use of high-dimensional geometric features in characterizing such chondrocyte patterns in the presence or absence of osteoarthritic damage. Geometrical features derived from the scaling index method (SIM) and statistical features derived from gray-level co-occurrence matrices were extracted from 842 regions of interest (ROI) annotated on PCI-CT images of ex vivo human patellar cartilage specimens. These features were subsequently used in a machine learning task with support vector regression to classify ROIs as healthy or osteoarthritic; classification performance was evaluated using the area under the receiver-operating characteristic curve (AUC). SIM-derived geometrical features exhibited the best classification performance (AUC, 0.95 ± 0.06) and were most robust to changes in ROI size. These results suggest that such geometrical features can provide a detailed characterization of the chondrocyte organization in the cartilage matrix in an automated and non-subjective manner, while also enabling classification of cartilage as healthy or osteoarthritic with high accuracy. Such features could potentially serve as imaging markers for evaluating osteoarthritis progression and its response to different therapeutic intervention strategies.

Influence of media with different acidity on structure of FeNi nanotubes

NASA Astrophysics Data System (ADS)

Shumskaya, Alena; Kaniukov, Egor; Kutuzau, Maksim; Bundyukova, Victoria; Tulebayeva, Dinara; Kozlovskiy, Artem; Borgekov, Daryn; Kenzhina, Inesh; Zdorovets, Maxim

2018-04-01

A detailed analysis of the structure features of FeNi nanotubes exposed at environment with different acidity is carried out. It is demonstrated that the exposure of the nanostructures in the environment with high acidity causes the structure deformation, leading to sharply increasing of the presents of oxide phases and partial amorphization of nanotubes walls that determined the rate of FeNi nanotubes destruction. It was established that the evolution of the crystal structure parameters concerned with appearance of oxide phases and with formation of disorder regions as a result of oxidation processes.

Observations of the structure and evolution of solar flares with a soft X-ray telescope

NASA Technical Reports Server (NTRS)

Vorpahl, J. A.; Gibson, E. G.; Landecker, P. B.; Mckenzie, D. L.; Underwood, J. M.

1975-01-01

Soft X ray flare events were observed with the S-056 X-ray telescope that was part of the ATM complement of instruments aboard SKYLAB. Analyses of these data are reported. The observations are summarized and a detailed discussion of the X-ray flare structures is presented. The data indicated that soft X-ray emitted by a flare come primarily from an intense well-defined core surrounded by a region of fainter, more diffuse emission. An analysis of flare evolution indicates evidence for preliminary heating and energy release prior to the main phase of the flare. Core features are found to be remarkably stable and retain their shape throughout a flare. Most changes in the overall configuration seem to be result of the appearance, disappearance or change in brightness of individual features, rather than the restructuring or reorientation of these features. Brief comparisons with several theories are presented.

XtalOpt  version r9: An open-source evolutionary algorithm for crystal structure prediction

DOE PAGES

Falls, Zackary; Lonie, David C.; Avery, Patrick; ...

2015-10-23

This is a new version of XtalOpt, an evolutionary algorithm for crystal structure prediction available for download from the CPC library or the XtalOpt website, http://xtalopt.github.io. XtalOpt is published under the Gnu Public License (GPL), which is an open source license that is recognized by the Open Source Initiative. We have detailed the new version incorporates many bug-fixes and new features here and predict the crystal structure of a system from its stoichiometry alone, using evolutionary algorithms.

Versatile simulation testbed for rotorcraft speech I/O system design

NASA Technical Reports Server (NTRS)

Simpson, Carol A.

1986-01-01

A versatile simulation testbed for the design of a rotorcraft speech I/O system is described in detail. The testbed will be used to evaluate alternative implementations of synthesized speech displays and speech recognition controls for the next generation of Army helicopters including the LHX. The message delivery logic is discussed as well as the message structure, the speech recognizer command structure and features, feedback from the recognizer, and random access to controls via speech command.

An image-processing method to detect sub-optical features based on understanding noise in intensity measurements.

PubMed

Bhatia, Tripta

2018-07-01

Accurate quantitative analysis of image data requires that we distinguish between fluorescence intensity (true signal) and the noise inherent to its measurements to the extent possible. We image multilamellar membrane tubes and beads that grow from defects in the fluid lamellar phase of the lipid 1,2-dioleoyl-sn-glycero-3-phosphocholine dissolved in water and water-glycerol mixtures by using fluorescence confocal polarizing microscope. We quantify image noise and determine the noise statistics. Understanding the nature of image noise also helps in optimizing image processing to detect sub-optical features, which would otherwise remain hidden. We use an image-processing technique "optimum smoothening" to improve the signal-to-noise ratio of features of interest without smearing their structural details. A high SNR renders desired positional accuracy with which it is possible to resolve features of interest with width below optical resolution. Using optimum smoothening, the smallest and the largest core diameter detected is of width [Formula: see text] and [Formula: see text] nm, respectively, discussed in this paper. The image-processing and analysis techniques and the noise modeling discussed in this paper can be used for detailed morphological analysis of features down to sub-optical length scales that are obtained by any kind of fluorescence intensity imaging in the raster mode.

Spectral feature variations in x-ray diffraction imaging systems

NASA Astrophysics Data System (ADS)

Wolter, Scott D.; Greenberg, Joel A.

2016-05-01

Materials with different atomic or molecular structures give rise to unique scatter spectra when measured by X-ray diffraction. The details of these spectra, though, can vary based on both intrinsic (e.g., degree of crystallinity or doping) and extrinsic (e.g., pressure or temperature) conditions. While this sensitivity is useful for detailed characterizations of the material properties, these dependences make it difficult to perform more general classification tasks, such as explosives threat detection in aviation security. A number of challenges, therefore, currently exist for reliable substance detection including the similarity in spectral features among some categories of materials combined with spectral feature variations from materials processing and environmental factors. These factors complicate the creation of a material dictionary and the implementation of conventional classification and detection algorithms. Herein, we report on two prominent factors that lead to variations in spectral features: crystalline texture and temperature variations. Spectral feature comparisons between materials categories will be described for solid metallic sheet, aqueous liquids, polymer sheet, and metallic, organic, and inorganic powder specimens. While liquids are largely immune to texture effects, they are susceptible to temperature changes that can modify their density or produce phase changes. We will describe in situ temperature-dependent measurement of aqueous-based commercial goods in the temperature range of -20°C to 35°C.

Analysis of active volcanoes from the Earth Observing System

NASA Technical Reports Server (NTRS)

Mouginis-Mark, Peter; Rowland, Scott; Crisp, Joy; Glaze, Lori; Jones, Kenneth; Kahle, Anne; Pieri, David; Zebker, Howard; Krueger, Arlin; Walter, Lou

1991-01-01

The Earth Observing System (EOS) scheduled for launch in 1997 and 1999 is briefly described, and the EOS volcanology investigation objectives are discussed. The volcanology investigation will include long- and short-term monitoring of selected volcanoes, the detection of precursor activity associated with unanticipated eruptions, and a detailed study of on-going eruptions. A variety of instruments on the EOS platforms will enable the study of local- and regional-scale thermal and deformational features of volcanoes, and the chemical and structural features of volcanic eruption plumes and aerosols.

Morphological characters of the thickbody skate Amblyraja frerichsi (Krefft 1968) (Rajiformes: Rajidae), with notes on its biology.

PubMed

Bustamante, Carlos; Lamilla, Julio; Concha, Francisco; Ebert, David A; Bennett, Michael B

2012-01-01

Detailed descriptions of morphological features, morphometrics, neurocranium anatomy, clasper structure and egg case descriptions are provided for the thickbody skate Amblyraja frerichsi; a rare, deep-water species from Chile, Argentina and Falkland Islands. The species diagnosis is complemented from new observations and aspects such as colour, size and distribution are described. Geographic and bathymetric distributional ranges are discussed as relevant features of this taxońs biology. Additionally, the conservation status is assessed including bycatch records from Chilean fisheries.

Morphological Characters of the Thickbody Skate Amblyraja frerichsi (Krefft 1968) (Rajiformes: Rajidae), with Notes on Its Biology

PubMed Central

Bustamante, Carlos; Lamilla, Julio; Concha, Francisco; Ebert, David A.; Bennett, Michael B.

2012-01-01

Detailed descriptions of morphological features, morphometrics, neurocranium anatomy, clasper structure and egg case descriptions are provided for the thickbody skate Amblyraja frerichsi; a rare, deep-water species from Chile, Argentina and Falkland Islands. The species diagnosis is complemented from new observations and aspects such as colour, size and distribution are described. Geographic and bathymetric distributional ranges are discussed as relevant features of this taxońs biology. Additionally, the conservation status is assessed including bycatch records from Chilean fisheries. PMID:22768186

Optical coherence tomography angiography of normal skin and inflammatory dermatologic conditions.

PubMed

Deegan, Anthony J; Talebi-Liasi, Faezeh; Song, Shaozhen; Li, Yuandong; Xu, Jingjiang; Men, Shaojie; Shinohara, Michi M; Flowers, Mary E; Lee, Stephanie J; Wang, Ruikang K

2018-03-01

In clinical dermatology, the identification of subsurface vascular and structural features known to be associated with numerous cutaneous pathologies remains challenging without the use of invasive diagnostic tools. To present an advanced optical coherence tomography angiography (OCTA) method to directly visualize capillary-level vascular and structural features within skin in vivo. An advanced OCTA system with a 1310 nm wavelength was used to image the microvascular and structural features of various skin conditions. Subjects were enrolled and OCTA imaging was performed with a field of view of approximately 10 × 10 mm. Skin blood flow was identified using an optical microangiography (OMAG) algorithm. Depth-resolved microvascular networks and structural features were derived from segmented volume scans, representing tissue slabs of 0-132, 132-330, and 330-924 μm, measured from the surface of the skin. Subjects with both healthy and pathological conditions, such as benign skin lesions, psoriasis, chronic graft-versus-host-disease (cGvHD), and scleroderma, were OCTA scanned. Our OCTA results detailed variations in vascularization and local anatomical characteristics, for example, depth-dependent vascular, and structural alterations in psoriatic skin, alongside their resolve over time; vascular density changes and distribution irregularities, together with corresponding structural depositions in the skin of cGvHD patients; and vascular abnormalities in the nail folds of a patient with scleroderma. OCTA can image capillary blood flow and structural features within skin in vivo, which has the potential to provide new insights into the pathophysiology, as well as dynamic changes of skin diseases, valuable for diagnoses, and non-invasive monitoring of disease progression and treatment. Lasers Surg. Med. 50:183-193, 2018. © 2018 Wiley Periodicals, Inc. © 2018 Wiley Periodicals, Inc.

UAV-based urban structural damage assessment using object-based image analysis and semantic reasoning

NASA Astrophysics Data System (ADS)

Fernandez Galarreta, J.; Kerle, N.; Gerke, M.

2015-06-01

Structural damage assessment is critical after disasters but remains a challenge. Many studies have explored the potential of remote sensing data, but limitations of vertical data persist. Oblique imagery has been identified as more useful, though the multi-angle imagery also adds a new dimension of complexity. This paper addresses damage assessment based on multi-perspective, overlapping, very high resolution oblique images obtained with unmanned aerial vehicles (UAVs). 3-D point-cloud assessment for the entire building is combined with detailed object-based image analysis (OBIA) of façades and roofs. This research focuses not on automatic damage assessment, but on creating a methodology that supports the often ambiguous classification of intermediate damage levels, aiming at producing comprehensive per-building damage scores. We identify completely damaged structures in the 3-D point cloud, and for all other cases provide the OBIA-based damage indicators to be used as auxiliary information by damage analysts. The results demonstrate the usability of the 3-D point-cloud data to identify major damage features. Also the UAV-derived and OBIA-processed oblique images are shown to be a suitable basis for the identification of detailed damage features on façades and roofs. Finally, we also demonstrate the possibility of aggregating the multi-perspective damage information at building level.

TLS from fundamentals to practice

PubMed Central

Urzhumtsev, Alexandre; Afonine, Pavel V.; Adams, Paul D.

2014-01-01

The Translation-Libration-Screw-rotation (TLS) model of rigid-body harmonic displacements introduced in crystallography by Schomaker & Trueblood (1968) is now a routine tool in macromolecular studies and is a feature of most modern crystallographic structure refinement packages. In this review we consider a number of simple examples that illustrate important features of the TLS model. Based on these examples simplified formulae are given for several special cases that may occur in structure modeling and refinement. The derivation of general TLS formulae from basic principles is also provided. This manuscript describes the principles of TLS modeling, as well as some select algorithmic details for practical application. An extensive list of applications references as examples of TLS in macromolecular crystallography refinement is provided. PMID:25249713

Low-angle normal faulting and isostatic response in the Gulf of Suez: Evidence from seismic interpretation and geometric reconstruction

NASA Technical Reports Server (NTRS)

Perry, S. K.; Schamel, S.

1985-01-01

Tectonic extension within continental crust creates a variety of major features best classed as extensional orogens. These features have come under increasing attention in recent years, with the welding of field observation and theoretical concepts. Most recent advances have come from the Basin and Range Province of the southwestern United States and from the North Sea. Application of these geometric and isostatic concepts, in combination with seismic interpretation, to the southern Gulf of Suez, an active extensional orogen, allows generation of detailed structural maps and geometrically balanced sections which suggest a regional structural model. Geometric models which should prove to be a valuable adjunct to numerical and thermal models for the rifting process are discussed.

CIRCAL-2 - General-purpose on-line circuit design.

NASA Technical Reports Server (NTRS)

Dertouzos, M. L.; Jessel, G. P.; Stinger, J. R.

1972-01-01

CIRCAL-2 is a second-generation general-purpose on-line circuit-design program with the following main features: (1) multiple-analysis capability; (2) uniform and general data structures for handling text editing, network representations, and output results, regardless of analysis; (3) special techniques and structures for minimizing and controlling user-program interaction; (4) use of functionals for the description of hysteresis and heat effects; and (5) ability to define optimization procedures that 'replace' the user. The paper discusses the organization of CIRCAL-2, the aforementioned main features, and their consequences, such as a set of network elements and models general enough for most analyses and a set of functions tailored to circuit-design requirements. The presentation is descriptive, concentrating on conceptual rather than on program implementation details.

DNAproDB: an interactive tool for structural analysis of DNA–protein complexes

PubMed Central

Sagendorf, Jared M.

2017-01-01

Abstract Many biological processes are mediated by complex interactions between DNA and proteins. Transcription factors, various polymerases, nucleases and histones recognize and bind DNA with different levels of binding specificity. To understand the physical mechanisms that allow proteins to recognize DNA and achieve their biological functions, it is important to analyze structures of DNA–protein complexes in detail. DNAproDB is a web-based interactive tool designed to help researchers study these complexes. DNAproDB provides an automated structure-processing pipeline that extracts structural features from DNA–protein complexes. The extracted features are organized in structured data files, which are easily parsed with any programming language or viewed in a browser. We processed a large number of DNA–protein complexes retrieved from the Protein Data Bank and created the DNAproDB database to store this data. Users can search the database by combining features of the DNA, protein or DNA–protein interactions at the interface. Additionally, users can upload their own structures for processing privately and securely. DNAproDB provides several interactive and customizable tools for creating visualizations of the DNA–protein interface at different levels of abstraction that can be exported as high quality figures. All functionality is documented and freely accessible at http://dnaprodb.usc.edu. PMID:28431131

Monte Carlo simulations of the detailed iron absorption line profiles from thermal winds in X-ray binaries

NASA Astrophysics Data System (ADS)

Tomaru, Ryota; Done, Chris; Odaka, Hirokazu; Watanabe, Shin; Takahashi, Tadayuki

2018-05-01

Blueshifted absorption lines from highly ionized iron are seen in some high inclination X-ray binary systems, indicating the presence of an equatorial disc wind. This launch mechanism is under debate, but thermal driving should be ubiquitous. X-ray irradiation from the central source heats disc surface, forming a wind from the outer disc where the local escape velocity is lower than the sound speed. The mass-loss rate from each part of the disc is determined by the luminosity and spectral shape of the central source. We use these together with an assumed density and velocity structure of the wind to predict the column density and ionization state, then combine this with a Monte Carlo radiation transfer to predict the detailed shape of the absorption (and emission) line profiles. We test this on the persistent wind seen in the bright neutron star binary GX 13+1, with luminosity L/LEdd ˜ 0.5. We approximately include the effect of radiation pressure because of high luminosity, and compute line features. We compare these to the highest resolution data, the Chandra third-order grating spectra, which we show here for the first time. This is the first physical model for the wind in this system, and it succeeds in reproducing many of the features seen in the data, showing that the wind in GX13+1 is most likely a thermal-radiation driven wind. This approach, combined with better streamline structures derived from full radiation hydrodynamic simulations, will allow future calorimeter data to explore the detail wind structure.

In the Image of Confucius: The Education and Preparation of Teachers in Taiwan.

ERIC Educational Resources Information Center

Smith, Douglas C.

This book reviews both preservice and inservice teacher education in the Republic of China and provides detailed analyses. In the first chapter, an overview of the educational system's structure in modern Taiwan and the United States is presented and comparisons drawn. Features of Chinese educational and intellectual thought and philosophy are…

Structure and Strategies in Children's Educational Television: The Roles of Program Type and Learning Strategies in Children's Learning

ERIC Educational Resources Information Center

Linebarger, Deborah L.; Piotrowski, Jessica Taylor

2010-01-01

Educational TV has been consistently linked to children's learning. In this research, educational TV characteristics were identified, coded, and tested for their influence on children's program-specific comprehension and vocabulary outcomes. Study 1 details a content analysis of TV features including a program's macrostructure (i.e., narrative or…

Mineral deposits in western Saudi Arabia; a preliminary report

USGS Publications Warehouse

Roberts, Ralph Jackson; Greenwood, William R.; Worl, Ronald G.; Dodge, F.C.W.; Kiilsgaard, Thor H.

1975-01-01

In order to effectively carry on a search for new mineral deposits, the belts should be mapped in detail, with emphasis on the delineation of stratigraphic and structural features that control metallization. In addition, geochemical and geophysical studies should be made of promising areas to outline exploration targets. These targets could then be systematically explored.

Structural Mapping of Paterae and Mountains on Io: Implications for Crustal Stresses and Feature Evolution

NASA Astrophysics Data System (ADS)

Ahern, A.; Radebaugh, J.; Christiansen, E. H.; Harris, R. A.

2015-12-01

Paterae and mountains are some of the most distinguishing and well-distributed surface features on Io, and they reveal the role of tectonism in Io's crust. Paterae, similar to calderas, are volcano-tectonic collapse features that often have straight margins. Io's mountains are some of the highest in the solar system and contain linear features that reveal crustal stresses. Paterae and mountains are often found adjacent to one another, suggesting possible genetic relationships. We have produced twelve detailed regional structural maps from high-resolution images of relevant features, where available, as well as a global structural map from the Io Global Color Mosaic. The regional structural maps identify features such as fractures, lineations, folds, faults, and mass wasting scarps, which are then interpreted in the context of global and regional stress regimes. A total of 1048 structural lineations have been identified globally. Preliminary analyses of major thrust and normal fault orientations are dominantly 90° offset from each other, suggesting the maximum contractional stresses leading to large mountain formation are not a direct result of tidal extension. Rather, these results corroborate the model of volcanic loading of the crust and global shortening, leading to thrust faulting and uplift of coherent crustal blocks. Several paterae, such as Hi'iaka and Tohil, are found adjacent to mountains inside extensional basins where lava has migrated up normal faults to erupt onto patera floors. Over time, mass wasting and volcanic resurfacing can change mountains from young, steep, and angular peaks to older, gentler, and more rounded hills. Mass wasting scarps make up 53% of all features identified. The structural maps highlight the significant effect of mass wasting on Io's surface, the evolution of mountains through time, the role of tectonics in the formation of paterae, and the formation of mountains through global contraction due to volcanism.

A Cloud Microphysics Model for the Gas Giant Planets

NASA Astrophysics Data System (ADS)

Palotai, Csaba J.; Le Beau, Raymond P.; Shankar, Ramanakumar; Flom, Abigail; Lashley, Jacob; McCabe, Tyler

2016-10-01

Recent studies have significantly increased the quality and the number of observed meteorological features on the jovian planets, revealing banded cloud structures and discrete features. Our current understanding of the formation and decay of those clouds also defines the conceptual modes about the underlying atmospheric dynamics. The full interpretation of the new observational data set and the related theories requires modeling these features in a general circulation model (GCM). Here, we present details of our bulk cloud microphysics model that was designed to simulate clouds in the Explicit Planetary Hybrid-Isentropic Coordinate (EPIC) GCM for the jovian planets. The cloud module includes hydrological cycles for each condensable species that consist of interactive vapor, cloud and precipitation phases and it also accounts for latent heating and cooling throughout the transfer processes (Palotai and Dowling, 2008. Icarus, 194, 303-326). Previously, the self-organizing clouds in our simulations successfully reproduced the vertical and horizontal ammonia cloud structure in the vicinity of Jupiter's Great Red Spot and Oval BA (Palotai et al. 2014, Icarus, 232, 141-156). In our recent work, we extended this model to include water clouds on Jupiter and Saturn, ammonia clouds on Saturn, and methane clouds on Uranus and Neptune. Details of our cloud parameterization scheme, our initial results and their comparison with observations will be shown. The latest version of EPIC model is available as open source software from NASA's PDS Atmospheres Node.

Some recent experimental results related to nuclear chirality

NASA Astrophysics Data System (ADS)

Timár, J.; Kuti, I.; Sohler, D.; Starosta, K.; Koike, T.; Paul, E. S.

2014-09-01

Detailed band structures of three chiral-candidate nuclei, 134Pr, 132La and 103Rh have been studied. The aim of the study was twofold. First, to try to explore the reasons behind the contradiction between the theoretically predicted chirality in these nuclei and the recently observed fingerprints that suggest non-chiral interpretation for the previous chiral candidate band doublets. Second, to search for multiple chiral bands of different types in these nuclei. In 134Pr a new πh11/2vh11/2 band has been observed besides the previously known chiral-candidate πh11/2vh11/2 doublet. This new band and the yrare πh11/2vh11/2 band show the expected features of a chiral doublet structure. This fact combined with the observed similarity between the band structures of 134Pr and 132La suggests that chirality might exist in these nuclei. The detailed study of the 103Rh band structure resulted in the observation of two new chiral-doublet looking structures besides the previously known one. This is indicative of possible existence of multiple chiral doublet structure in this nucleus.

Brownian dynamics simulation of protein diffusion in crowded environments

NASA Astrophysics Data System (ADS)

Mereghetti, Paolo; Wade, Rebecca C.

2013-02-01

High macromolecular concentrations are a distinguishing feature of living organisms. Understanding how the high concentration of solutes affects the dynamic properties of biological macromolecules is fundamental for the comprehension of biological processes in living systems. We first describe the development of a Brownian dynamics simulation methodology to investigate the dynamic and structural properties of protein solutions using atomic-detail protein structures. We then discuss insights obtained from applying this approach to simulation of solutions of a range of types of proteins.

On the Electronic Structure of Cu Chlorophyllin and Its Breakdown Products: A Carbon K-Edge X-ray Absorption Spectroscopy Study.

PubMed

Witte, Katharina; Mantouvalou, Ioanna; Sánchez-de-Armas, Rocío; Lokstein, Heiko; Lebendig-Kuhla, Janina; Jonas, Adrian; Roth, Friedrich; Kanngießer, Birgit; Stiel, Holger

2018-02-15

Using near-edge X-ray absorption fine structure (NEXAFS) spectroscopy, the carbon backbone of sodium copper chlorophyllin (SCC), a widely used chlorophyll derivative, and its breakdown products are analyzed to elucidate their electronic structure and physicochemical properties. Using various sample preparation methods and complementary spectroscopic methods (including UV/Vis, X-ray photoelectron spectroscopy), a comprehensive insight into the SCC breakdown process is presented. The experimental results are supported by density functional theory calculations, allowing a detailed assignment of characteristic NEXAFS features to specific C bonds. SCC can be seen as a model system for the large group of porphyrins; thus, this work provides a novel and detailed description of the electronic structure of the carbon backbone of those molecules and their breakdown products. The achieved results also promise prospective optical pump/X-ray probe investigations of dynamic processes in chlorophyll-containing photosynthetic complexes to be analyzed more precisely.

Interpretation of aeromagnetic data in the Jameson Land Basin, central East Greenland: Structures and related mineralized systems

NASA Astrophysics Data System (ADS)

Brethes, Anaïs; Guarnieri, Pierpaolo; Rasmussen, Thorkild Maack; Bauer, Tobias Erich

2018-01-01

This paper provides a detailed interpretation of several aeromagnetic datasets over the Jameson Land Basin in central East Greenland. The interpretation is based on texture and lineament analysis of magnetic data and derivatives of these, in combination with geological field observations. Numerous faults and Cenozoic intrusions were identified and a chronological interpretation of the events responsible for the magnetic features is proposed built on crosscutting relationships and correlated with absolute ages. Lineaments identified in enhanced magnetic data are compared with structures controlling the mineralized systems occurring in the area and form the basis for the interpretations presented in this paper. Several structures associated with base metal mineralization systems that were known at a local scale are here delineated at a larger scale; allowing the identification of areas displaying favorable geological settings for mineralization. This study demonstrates the usefulness of high-resolution airborne magnetic data for detailed structural interpretation and mineral exploration in geological contexts such as the Jameson Land Basin.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miao, Yinbin; Mo, Kun; Yao, Tiankai

Here coordinated experimental efforts to quantitatively correlate crystallographic orientation and surface faceting features in UO2 are reported upon. A sintered polycrystalline UO2 sample was thermally etched to induce the formation of surface faceting features. Synchrotron Laue microdiffraction was used to obtain a precise crystallographic orientation map for the UO2 surface grains. Scanning electron microscopy (SEM) was utilized to collect the detailed information on the surface morphology of the sample. The surface faceting features were found to be highly dependent on the crystallographic orientation. In most cases, Triple-plane structures containing one {100} plane and two {111} planes were found to dominatemore » the surface of UO2. The orientation-faceting relationship established in this study revealed a practical and efficient method of determining crystallographic orientation based on the surface features captured by SEM images.« less

Fast Lithium-Ion Transportation in Crystalline Polymer Electrolytes.

PubMed

Fu, Xiao-Bin; Yang, Guang; Wu, Jin-Ze; Wang, Jia-Chen; Chen, Qun; Yao, Ye-Feng

2018-01-05

Fast lithium-ion transportation is found in the crystalline polymer electrolytes, α-CD-PEO n /Li + (n=12, 40), prepared by self-assembly of α-cyclodextrin (CD), polyethylene oxide (PEO) and Li + salts. A detailed solid-state NMR study combined with the X-ray diffraction technique reveals the unique structural features of the samples, that is, a) the tunnel structure formed by the assembled CDs, providing the ordered long-range pathway for Li + ion transportation; b) the all-trans conformational sequence of the PEO chains in the tunnels, attenuating significantly the coordination between Li + and the EO segments. The origin of the fast lithium-ion transportation has been attributed to these unique structural features. This work demonstrates the first example in solid polymer electrolytes (SPEs) for "creating" fast ion transportation through material design and will find potential applications in the design of new ionconducting SPE materials. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

A field investigation of the basaltic ring structures of the Channeled Scabland and the relevance to Mars

USGS Publications Warehouse

Kestay, Laszlo P.; Jaeger, Windy L.

2015-01-01

The basaltic ring structure (BRS) is a class of peculiar features only reported in the Channeled Scabland of eastern Washington State. They have been suggested to be good analogs, however, for some circular features on Mars. BRSs are found where Pleistocene floods scoured the Columbia River Basin, stripping off the uppermost part of the Miocene Columbia River Basalt Group and exposing structures that were previously embedded in the lava. The “Odessa Craters,” near Odessa, WA, are 50–500-m-wide BRSs that are comprised of discontinuous, concentric outcrops of subvertically-jointed basalt and autointrusive dikes. Detailed field investigation of the Odessa Craters in planform and a cross-sectional exposure of a similar structure above Banks Lake, WA, lead us to propose that BRSs formed by concurrent phreatovolcanism and lava flow inflation. In this model, phreatovolcanic (a.k.a., “rootless”) cones formed on a relatively thin, active lava flow; the lava flow inflated around the cones, locally inverting topography; tensile stresses caused concentric fracturing of the lava crust; lava from within the molten interior of the flow exploited the fractures and buried the phreatovolcanic cones; and subsequent erosive floods excavated the structures. Another population of BRSs near Tokio Station, WA, consists of single-ringed, raised-rimmed structures that are smaller and more randomly distributed than the Odessa Craters. We find evidence for a phreatovolcanic component to the origin as well, and hypothesize that they are either flood-eroded phreatovolcanic cones or Odessa Crater-like BRSs. This work indicates that BRSs are not good analogs to the features on Mars because the martian features are found on the uneroded surfaces. Despite this, the now superseded concepts for BRS formation are useful for understanding the formation of the martian features.

Similarity measure and domain adaptation in multiple mixture model clustering: An application to image processing.

PubMed

Leong, Siow Hoo; Ong, Seng Huat

2017-01-01

This paper considers three crucial issues in processing scaled down image, the representation of partial image, similarity measure and domain adaptation. Two Gaussian mixture model based algorithms are proposed to effectively preserve image details and avoids image degradation. Multiple partial images are clustered separately through Gaussian mixture model clustering with a scan and select procedure to enhance the inclusion of small image details. The local image features, represented by maximum likelihood estimates of the mixture components, are classified by using the modified Bayes factor (MBF) as a similarity measure. The detection of novel local features from MBF will suggest domain adaptation, which is changing the number of components of the Gaussian mixture model. The performance of the proposed algorithms are evaluated with simulated data and real images and it is shown to perform much better than existing Gaussian mixture model based algorithms in reproducing images with higher structural similarity index.

Similarity measure and domain adaptation in multiple mixture model clustering: An application to image processing

PubMed Central

Leong, Siow Hoo

2017-01-01

This paper considers three crucial issues in processing scaled down image, the representation of partial image, similarity measure and domain adaptation. Two Gaussian mixture model based algorithms are proposed to effectively preserve image details and avoids image degradation. Multiple partial images are clustered separately through Gaussian mixture model clustering with a scan and select procedure to enhance the inclusion of small image details. The local image features, represented by maximum likelihood estimates of the mixture components, are classified by using the modified Bayes factor (MBF) as a similarity measure. The detection of novel local features from MBF will suggest domain adaptation, which is changing the number of components of the Gaussian mixture model. The performance of the proposed algorithms are evaluated with simulated data and real images and it is shown to perform much better than existing Gaussian mixture model based algorithms in reproducing images with higher structural similarity index. PMID:28686634

Structural Characterization by Cross-linking Reveals the Detailed Architecture of a Coatomer-related Heptameric Module from the Nuclear Pore Complex*

PubMed Central

Shi, Yi; Fernandez-Martinez, Javier; Tjioe, Elina; Pellarin, Riccardo; Kim, Seung Joong; Williams, Rosemary; Schneidman-Duhovny, Dina; Sali, Andrej; Rout, Michael P.; Chait, Brian T.

2014-01-01

Most cellular processes are orchestrated by macromolecular complexes. However, structural elucidation of these endogenous complexes can be challenging because they frequently contain large numbers of proteins, are compositionally and morphologically heterogeneous, can be dynamic, and are often of low abundance in the cell. Here, we present a strategy for the structural characterization of such complexes that has at its center chemical cross-linking with mass spectrometric readout. In this strategy, we isolate the endogenous complexes using a highly optimized sample preparation protocol and generate a comprehensive, high-quality cross-linking dataset using two complementary cross-linking reagents. We then determine the structure of the complex using a refined integrative method that combines the cross-linking data with information generated from other sources, including electron microscopy, X-ray crystallography, and comparative protein structure modeling. We applied this integrative strategy to determine the structure of the native Nup84 complex, a stable hetero-heptameric assembly (∼600 kDa), 16 copies of which form the outer rings of the 50-MDa nuclear pore complex (NPC) in budding yeast. The unprecedented detail of the Nup84 complex structure reveals previously unseen features in its pentameric structural hub and provides information on the conformational flexibility of the assembly. These additional details further support and augment the protocoatomer hypothesis, which proposes an evolutionary relationship between vesicle coating complexes and the NPC, and indicates a conserved mechanism by which the NPC is anchored in the nuclear envelope. PMID:25161197

Application of ERTS-1 imagery to detecting and mapping modern erosion features and to monitoring erosional changes, in southern Arizona

NASA Technical Reports Server (NTRS)

Morrison, R. B. (Principal Investigator); Cooley, M. E.

1973-01-01

The author has identified the following significant results. The chief results during the reporting period were three 1:1,000,000 scale maps made from one ERTS-1 frame (1085-17330, 16 October 1972) showing: (1) the three most important types of materials in terms of the modern erosion problem: the readily erodible soils, gravel piedmonts and basin-fill areas, and consolidated rocks; (2) alluvial fans (dissected and relatively undissected); and (3) (as an additional bonus) linear structural features. Eight key areas (small parts of the whole study area) were selected for detailed study, and mapping was started in two of them, by interpretation of ultrahigh (U-2 and RB-57) airphotos, supplemented by field studies. In these areas detailed mapping was done not only on the modern erosion phenomena (arroyos, gullies, modern flood plains and terraces, and areas of sheet erosion and deposition), but also other features pertinent to the erosion problem, such as slope-local relief, landforms rock units, soil particle size and erodibility, and classes of vegetative cover.

Fine flow structures in the transition region small-scale loops

NASA Astrophysics Data System (ADS)

Yan, L.; Peter, H.; He, J.; Wei, Y.

2016-12-01

The observation and model have suggested that the transition region EUV emission from the quiet sun region is contributed by very small scale loops which have not been resolved. Recently, the observation from IRIS has revealed that this kind of small scale loops. Based on the high resolution spectral and imaging observation from IRIS, much more detail work needs to be done to reveal the fine flow features in this kind of loop to help us understand the loop heating. Here, we present a detail statistical study of the spatial and temporal evolution of Si IV line profiles of small scale loops and report the spectral features: there is a transition from blue (red) wing enhancement dominant to red (blue) wing enhancement dominant along the cross-section of the loop, which is independent of time. This feature appears as the loop appear and disappear as the loop un-visible. This is probably the signature of helical flow along the loop. The result suggests that the brightening of this kind of loop is probably due to the current dissipation heating in the twisted magnetic field flux tube.

High Definition Confocal Imaging Modalities for the Characterization of Tissue-Engineered Substitutes.

PubMed

Mayrand, Dominique; Fradette, Julie

2018-01-01

Optimal imaging methods are necessary in order to perform a detailed characterization of thick tissue samples from either native or engineered tissues. Tissue-engineered substitutes are featuring increasing complexity including multiple cell types and capillary-like networks. Therefore, technical approaches allowing the visualization of the inner structural organization and cellular composition of tissues are needed. This chapter describes an optical clearing technique which facilitates the detailed characterization of whole-mount samples from skin and adipose tissues (ex vivo tissues and in vitro tissue-engineered substitutes) when combined with spectral confocal microscopy and quantitative analysis on image renderings.

A new fossil fern assignable to Gleicheniaceae from Late Cretaceous sediments of New Jersey.

PubMed

Gandolfo, M; Nixon, K; Crepet, W; Ratcliffe, G

1997-04-01

The recent discovery of well-preserved charcoalified rhizomes, petioles. pinnules, sori, and spores from the Upper Cretaceous of New Jersey provides the basis for the description of a new gleicheniaceous fern, Boodlepteris turoniana. The fossils were collected from unconsolidated sediments of Turonian age (~90 MYBP million years before present; Raritan/ Lower Magothy Formation, Potomac Group). These deposits are rich in angiosperms, but also have a limited representation of fern and gymnosperm remains. Fossil specimens from this locality are particularly remarkable in that minute detail, including anatomical features, are often preserved. Some Boodlepteris specimens have cell by cell preservation that reveals the nature and structure of the stele in rhizomes and petioles, and others show minute details of the sori borne on fertile pinnae. Although these specimens are not in organic connection, there are sufficient structural and anatomical details preserved to confidently suggest that they belong to the same taxon. Cladistic analysis of the fossils, both separately and as a reconstruction, support assignment of Boodlepteris to the extant family Gleicheniaceae.

Classical And Quantum Rainbow Scattering From Surfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winter, H.; Schueller, A.; Busch, M.

2011-06-01

The structure of clean and adsorbate covered surfaces as well as of ultrathin films can be investigated by grazing scattering of fast atoms. We present two recent experimental techniques which allow one to study the structure of ordered arrangements of surface atoms in detail. (1) Rainbow scattering under axial surface channeling conditions, and (2) fast atom diffraction. Our examples demonstrate the attractive features of grazing fast atom scattering as a powerful analytical tool in studies on the structure of surfaces. We will concentrate our discussion on the structure of ultrathin silica films on a Mo(112) surface and of adsorbed oxygenmore » atoms on a Fe(110) surface.« less

Structural impact and crashworthiness. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davies, G.A.O.

1984-01-01

This volume contains the keynote addresses of those speakers invited to the International Confernece on Structural Impact and Crashworthiness held at Imperial College, London, in 1984. The speakers represent authoritative views on topics covering the spectrum of impact and crashworthiness involving several materials. The theme of this book may be summarized as 'understanding/modelling/prediction.' Ultimately a crashworthy design depends on many conceptual decisions being correct in the initial design phase. The overall configuration of a structure may be paramount; the detail design of joints and so on has to enable the structure to exploit energy absorption; the fail-safe features must notmore » be prohibitively expensive.« less

On the topological structure of multinationals network

NASA Astrophysics Data System (ADS)

Joyez, Charlie

2017-05-01

This paper uses a weighted network analysis to examine the structure of multinationals' implantation countries network. Based on French firm-level dataset of multinational enterprises (MNEs) the network analysis provides information on each country position in the network and in internationalization strategies of French MNEs through connectivity preferences among the nodes. The paper also details network-wide features and their recent evolution toward a more decentralized structure. While much has been said on international trade network, this paper shows that multinational firms' studies would also benefit from network analysis, notably by investigating the sensitivity of the network construction to firm heterogeneity.

Application of PALSAR-2 Remote Sensing Data for Landslide Hazard Mapping in Kelantan River Basin, Peninsular Malaysia

NASA Astrophysics Data System (ADS)

Beiranvand Pour, Amin; Hashim, Mazlan

2016-06-01

Yearly, several landslides ensued during heavy monsoons rainfall in Kelantan river basin, peninsular Malaysia, which are obviously connected to geological structures and topographical features of the region. In this study, the recently launched Phased Array type L-band Synthetic Aperture Radar-2 (PALSAR-2) onboard the Advanced Land Observing Satellite-2 (ALOS-2), remote sensing data were used to map geological structural and topographical features in the Kelantan river basin for identification of high potential risk and susceptible zones for landslides. Adaptive Local Sigma filter was selected and applied to accomplish speckle reduction and preserving both edges and features in PALSAR-2 fine mode observation images. Different polarization images were integrated to enhance geological structures. Additionally, directional filters were applied to the PALSAR-2 Local Sigma resultant image for edge enhancement and detailed identification of linear features. Several faults, drainage patterns and lithological contact layers were identified at regional scale. In order to assess the results, fieldwork and GPS survey were conducted in the landslide affected zones in the Kelantan river basin. Results demonstrate the most of the landslides were associated with N-S, NNW-SSE and NE-SW trending faults, angulated drainage pattern and metamorphic and Quaternary units. Consequently, structural and topographical geology maps were produced for Kelantan river basin using PALSAR-2 data, which could be broadly applicable for landslide hazard mapping.

The European Spacelab structural design evolution

NASA Technical Reports Server (NTRS)

Thirkettle, A. J.

1982-01-01

Spacelab is a manned, reusable laboratory which is being developed for the European Space Agency (ESA). In its working mode it will fly in low earth orbit in the cargo bay of the Shuttle Transportation System (STS) Orbiter. A description is presented of the structural development of the various features of Spacelab. System requirements are considered along with structural requirements, quasi-static loads, acoustic loads, pressure loads, crash loads, ground loads, and the fatigue profile. Aspects of thermal environment generation are discussed, and questions regarding the design evolution of the pallet structure are examined. Details of pallet structure testing are reported, taking into account static strength tests, acoustic tests, the modal survey test, crash tests, and fatigue/fracture mechanics testing.

Transactions and Answer Judging in Multimedia Instruction: A Way to Transact with Features Appearing in Video and Graphic Images.

ERIC Educational Resources Information Center

Casey, Carl

1992-01-01

Discussion of transactions in computer-based instruction for ill-structured and visual domains focuses on two transactions developed for meteorology training that provide the capability to interact with video and graphic images at a very detailed level. Potential applications for the transactions are suggested, and early evaluation reports are…

SIGMA Release v1.2 - Capabilities, Enhancements and Fixes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahadevan, Vijay; Grindeanu, Iulian R.; Ray, Navamita

In this report, we present details on SIGMA toolkit along with its component structure, capabilities, and feature additions in FY15, release cycles, and continuous integration process. These software processes along with updated documentation are imperative to successfully integrate and utilize in several applications including the SHARP coupled analysis toolkit for reactor core systems funded under the NEAMS DOE-NE program.

Featured Image: New Detail in the Toothbrush Cluster

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2018-01-01

This spectacular composite (click here for the full image) reveals the galaxy cluster 1RXS J0603.3+4214, known as the Toothbrush cluster due to the shape of its most prominent radio relic. Featured in a recent publication led by Kamlesh Rajpurohit (Thuringian State Observatory, Germany), this image contains new Very Large Array (VLA) 1.5-GHz observations (red) showing the radio emission within the cluster. This is composited with a Chandra view of the X-ray emitting gas of the cluster (blue) and an optical image of the background from Subaru data. The new deep VLA data totaling 26 hours of observations provides a detailed look at the complex structure within the Toothbrush relic, revealing enigmatic filaments and twists (see below). This new data will help us to explore the possible merger history of this cluster, which is theorized to have caused the unusual shapes we see today. For more information, check out the original article linked below.High resolution VLA 12 GHz image of the Toothbrush showing the complex, often filamentary structures. [Rajpurohit et al. 2018]CitationK. Rajpurohit et al 2018 ApJ 852 65. doi:10.3847/1538-4357/aa9f13

Nuclear Physics Around the Unitarity Limit.

PubMed

König, Sebastian; Grießhammer, Harald W; Hammer, H-W; van Kolck, U

2017-05-19

We argue that many features of the structure of nuclei emerge from a strictly perturbative expansion around the unitarity limit, where the two-nucleon S waves have bound states at zero energy. In this limit, the gross features of states in the nuclear chart are correlated to only one dimensionful parameter, which is related to the breaking of scale invariance to a discrete scaling symmetry and set by the triton binding energy. Observables are moved to their physical values by small perturbative corrections, much like in descriptions of the fine structure of atomic spectra. We provide evidence in favor of the conjecture that light, and possibly heavier, nuclei are bound weakly enough to be insensitive to the details of the interactions but strongly enough to be insensitive to the exact size of the two-nucleon system.

Nonlocal sparse model with adaptive structural clustering for feature extraction of aero-engine bearings

NASA Astrophysics Data System (ADS)

Zhang, Han; Chen, Xuefeng; Du, Zhaohui; Li, Xiang; Yan, Ruqiang

2016-04-01

Fault information of aero-engine bearings presents two particular phenomena, i.e., waveform distortion and impulsive feature frequency band dispersion, which leads to a challenging problem for current techniques of bearing fault diagnosis. Moreover, although many progresses of sparse representation theory have been made in feature extraction of fault information, the theory also confronts inevitable performance degradation due to the fact that relatively weak fault information has not sufficiently prominent and sparse representations. Therefore, a novel nonlocal sparse model (coined NLSM) and its algorithm framework has been proposed in this paper, which goes beyond simple sparsity by introducing more intrinsic structures of feature information. This work adequately exploits the underlying prior information that feature information exhibits nonlocal self-similarity through clustering similar signal fragments and stacking them together into groups. Within this framework, the prior information is transformed into a regularization term and a sparse optimization problem, which could be solved through block coordinate descent method (BCD), is formulated. Additionally, the adaptive structural clustering sparse dictionary learning technique, which utilizes k-Nearest-Neighbor (kNN) clustering and principal component analysis (PCA) learning, is adopted to further enable sufficient sparsity of feature information. Moreover, the selection rule of regularization parameter and computational complexity are described in detail. The performance of the proposed framework is evaluated through numerical experiment and its superiority with respect to the state-of-the-art method in the field is demonstrated through the vibration signals of experimental rig of aircraft engine bearings.

Dynamical injections as the source of near geostationary quiet time particle spatial boundaries

NASA Technical Reports Server (NTRS)

Mauk, B. H.; Meng, C. I.

1983-01-01

The question whether the noon-dusk feature is a manifestation of the spatial structures that should arise from quasi-stationary convection is examined. The key consideration here is whether the energy dispersion of the feature can be explained. It is shown that the observed energy dispersion cannot be attributed to the standard stationary convection configurations, either perturbed or unperturbed. It is also demonstrated, using a detailed computer simulation, that the nighttime, double-spiral-shaped injection boundary (used previously to reproduce the fast changing nighttime features) is successful at reproducing the noon-dusk feature by allowing the particles to evolve for periods of 12 to 36 hours after the injection. It is stressed that the portion of the injection boundary responsible for the feature looks very different from the standard convection boundaries configuration. Conclusions are offered concerning the importance of quasi-stationary convection as the mechanism by which the near geostationary regions are populated.

A combined experimental and theoretical spectroscopic protocol for determination of the structure of heterogeneous catalysts: developing the information content of the resonance Raman spectra of M1 MoVO x .

PubMed

Kubas, Adam; Noak, Johannes; Trunschke, Annette; Schlögl, Robert; Neese, Frank; Maganas, Dimitrios

2017-09-01

Absorption and multiwavelength resonance Raman spectroscopy are widely used to investigate the electronic structure of transition metal centers in coordination compounds and extended solid systems. In combination with computational methodologies that have predictive accuracy, they define powerful protocols to study the spectroscopic response of catalytic materials. In this work, we study the absorption and resonance Raman spectra of the M1 MoVO x catalyst. The spectra were calculated by time-dependent density functional theory (TD-DFT) in conjunction with the independent mode displaced harmonic oscillator model (IMDHO), which allows for detailed bandshape predictions. For this purpose cluster models with up to 9 Mo and V metallic centers are considered to represent the bulk structure of MoVO x . Capping hydrogens were used to achieve valence saturation at the edges of the cluster models. The construction of model structures was based on a thorough bonding analysis which involved conventional DFT and local coupled cluster (DLPNO-CCSD(T)) methods. Furthermore the relationship of cluster topology to the computed spectral features is discussed in detail. It is shown that due to the local nature of the involved electronic transitions, band assignment protocols developed for molecular systems can be applied to describe the calculated spectral features of the cluster models as well. The present study serves as a reference for future applications of combined experimental and computational protocols in the field of solid-state heterogeneous catalysis.

The calculation of theoretical chromospheric models and the interpretation of the solar spectrum

NASA Technical Reports Server (NTRS)

Avrett, Eugene H.

1994-01-01

Since the early 1970s we have been developing the extensive computer programs needed to construct models of the solar atmosphere and to calculate detailed spectra for use in the interpretation of solar observations. This research involves two major related efforts: work by Avrett and Loeser on the Pandora computer program for non-LTE modeling of the solar atmosphere including a wide range of physical processes, and work by Kurucz on the detailed synthesis of the solar spectrum based on opacity data for over 58 million atomic and molecular lines. Our goals are to determine models of the various features observed on the sun (sunspots, different components of quiet and active regions, and flares) by means of physically realistic models, and to calculate detailed spectra at all wavelengths that match observations of those features. These two goals are interrelated: discrepancies between calculated and observed spectra are used to determine improvements in the structure of the models, and in the detailed physical processes used in both the model calculations and the spectrum calculations. The atmospheric models obtained in this way provide not only the depth variation of various atmospheric parameters, but also a description of the internal physical processes that are responsible for nonradiative heating, and for solar activity in general.

The calculation of theoretical chromospheric models and the interpretation of solar spectra from rockets and spacecraft

NASA Technical Reports Server (NTRS)

Avrett, Eugene H.

1993-01-01

Since the early 1970s we have been developing the extensive computer programs needed to construct models of the solar atmosphere and to calculate detailed spectra for use in the interpretation of solar observations. This research involves two major related efforts: work by Avrett and Loeser on the Pandora computer program for non-LTE modeling of the solar atmosphere including a wide range of physical processes, and work by Kurucz on the detailed synthesis of the solar spectrum based on opacity data for over 58 million atomic and molecular lines. Our goals are to determine models of the various features observed on the Sun (sunspots, different components of quiet and active regions, and flares) by means of physically realistic models, and to calculate detailed spectra at all wavelengths that match observations of those features. These two goals are interrelated: discrepancies between calculated and observed spectra are used to determine improvements in the structure of the models, and in the detailed physical processes used in both the model calculations and the spectrum calculations. The atmospheric models obtained in this way provide not only the depth variation of various atmospheric parameters, but also a description of the internal physical processes that are responsible for non-radiative heating, and for solar activity in general.

The Episodic Memory System: Neurocircuitry and Disorders

PubMed Central

Dickerson, Bradford C; Eichenbaum, Howard

2010-01-01

The ability to encode and retrieve our daily personal experiences, called episodic memory, is supported by the circuitry of the medial temporal lobe (MTL), including the hippocampus, which interacts extensively with a number of specific distributed cortical and subcortical structures. In both animals and humans, evidence from anatomical, neuropsychological, and physiological studies indicates that cortical components of this system have key functions in several aspects of perception and cognition, whereas the MTL structures mediate the organization and persistence of the network of memories whose details are stored in those cortical areas. Structures within the MTL, and particularly the hippocampus, have distinct functions in combining information from multiple cortical streams, supporting our ability to encode and retrieve details of events that compose episodic memories. Conversely, selective damage in the hippocampus, MTL, and other structures of the large-scale memory system, or deterioration of these areas in several diseases and disorders, compromises episodic memory. A growing body of evidence is converging on a functional organization of the cortical, subcortical, and MTL structures that support the fundamental features of episodic memory in humans and animals. PMID:19776728

Use of MAGSAT anomaly data for crustal structure and mineral resources in the US midcontinent

NASA Technical Reports Server (NTRS)

Carmichael, R. S. (Principal Investigator)

1981-01-01

While the preliminary magnetic anomaly map for the centra midcontinent is only in the hand-drawn stage, it agrees in broad aspects with the preliminary global MAGSAT map provided by NASA. Because of data evaluation and finer scale averaging, there are more detailed features which hold promise for eventual geological/crustal interpretation. Some current analysis is directed at examining whether a map data feature such as an elongated anomaly or trend, which seems parallel to satellite data tracks, is likely of crustal origin or is an artifact of the data set.

Cooperative research in terrestrial planetary geology and geophysics

NASA Technical Reports Server (NTRS)

1994-01-01

This final report for the period of July 1991 to August 1994 covered a variety of topics concerning the study of Earth and Mars. The Earth studies stressed the interpretation of the MAGSAT crustal magnetic anomalies in order to determine the geological structure, mineralogical composition, magnetic nature, and the historical background of submarine features, and also featured work in the area of terrestrial remote sensing. Mars research included the early evolution of the Martian atmosphere and hydrosphere and the investigations of the large Martian impact basins. Detailed summaries of the research is included, along with lists of the publications resulting from this research.

Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model

PubMed Central

Kim, Min Hyeok; Kim, Young Jin; Kim, Hee Ryung; Jeon, Tae-Joon; Choi, Jae Boong; Chung, Ka Young; Kim, Moon Ki

2016-01-01

Agonist-activated G protein-coupled receptors (GPCRs) interact with GDP-bound G protein heterotrimers (Gαβγ) promoting GDP/GTP exchange, which results in dissociation of Gα from the receptor and Gβγ. The GTPase activity of Gα hydrolyzes GTP to GDP, and the GDP-bound Gα interacts with Gβγ, forming a GDP-bound G protein heterotrimer. The G protein cycle is allosterically modulated by conformational changes of the Gα subunit. Although biochemical and biophysical methods have elucidated the structure and dynamics of Gα, the precise conformational mechanisms underlying the G protein cycle are not fully understood yet. Simulation methods could help to provide additional details to gain further insight into G protein signal transduction mechanisms. In this study, using the available X-ray crystal structures of Gα, we simulated the entire G protein cycle and described not only the steric features of the Gα structure, but also conformational changes at each step. Each reference structure in the G protein cycle was modeled as an elastic network model and subjected to normal mode analysis. Our simulation data suggests that activated receptors trigger conformational changes of the Gα subunit that are thermodynamically favorable for opening of the nucleotide-binding pocket and GDP release. Furthermore, the effects of GTP binding and hydrolysis on mobility changes of the C and N termini and switch regions are elucidated. In summary, our simulation results enabled us to provide detailed descriptions of the structural and dynamic features of the G protein cycle. PMID:27483005

New insights on ion track morphology in pyrochlores by aberration corrected scanning transmission electron microscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sachan, Ritesh; Zhang, Yanwen; Ou, Xin

Here we demonstrate the enhanced imaging capabilities of an aberration corrected scanning transmission electron microscope to advance the understanding of ion track structure in pyrochlore structured materials (i.e., Gd 2Ti 2O 7 and Gd 2TiZrO 7). Track formation occurs due to the inelastic transfer of energy from incident ions to electrons, and atomic-level details of track morphology as a function of energy-loss are revealed in the present work. A comparison of imaging details obtained by varying collection angles of detectors is discussed in the present work. A quantitative analysis of phase identification using high-angle annular dark field imaging is performedmore » on the ion tracks. Finally, a novel 3-dimensional track reconstruction method is provided that is based on depth dependent imaging of the ion tracks. The technique is used in extracting the atomic-level details of nanoscale features, such as the disordered ion tracks, which are embedded in relatively thicker matrix. Another relevance of the method is shown by measuring the tilt of the ion tracks relative to the electron beam incidence that helps in knowing the structure and geometry of ion tracks quantitatively.« less

New insights on ion track morphology in pyrochlores by aberration corrected scanning transmission electron microscopy

DOE PAGES

Sachan, Ritesh; Zhang, Yanwen; Ou, Xin; ...

2016-12-13

Here we demonstrate the enhanced imaging capabilities of an aberration corrected scanning transmission electron microscope to advance the understanding of ion track structure in pyrochlore structured materials (i.e., Gd 2Ti 2O 7 and Gd 2TiZrO 7). Track formation occurs due to the inelastic transfer of energy from incident ions to electrons, and atomic-level details of track morphology as a function of energy-loss are revealed in the present work. A comparison of imaging details obtained by varying collection angles of detectors is discussed in the present work. A quantitative analysis of phase identification using high-angle annular dark field imaging is performedmore » on the ion tracks. Finally, a novel 3-dimensional track reconstruction method is provided that is based on depth dependent imaging of the ion tracks. The technique is used in extracting the atomic-level details of nanoscale features, such as the disordered ion tracks, which are embedded in relatively thicker matrix. Another relevance of the method is shown by measuring the tilt of the ion tracks relative to the electron beam incidence that helps in knowing the structure and geometry of ion tracks quantitatively.« less

Dinocyst taphonomy, impact craters, cyst ghosts, and the Paleocene-Eocene thermal maximum (PETM)

USGS Publications Warehouse

Edwards, Lucy E.

2012-01-01

Dinocysts recovered from sediments related to the Chesapeake Bay impact structure in Virginia and the earliest Eocene suboxic environment in Maryland show strange and intriguing details of preservation. Features such as curled processes, opaque debris, breakage, microborings and cyst ghosts, among others, invite speculation about catastrophic depositional processes, rapid burial and biological and chemical decay. Selected specimens from seven cores taken in the coastal plain of Virginia and Maryland show abnormal preservation features in various combinations that merit illustration, description, discussion and further study. Although the depositional environments described are extreme, many of the features discussed are known from, or could be found in, other environments. These environments will show both similarities to and differences from the extreme environments here.

Structural hierarchy as a key to complex phase selection in Al-Sm

NASA Astrophysics Data System (ADS)

Ye, Z.; Zhang, F.; Sun, Y.; Nguyen, M. C.; Zhou, S. H.; Zhou, L.; Meng, F.; Ott, R. T.; Park, E.; Besser, M. F.; Kramer, M. J.; Ding, Z. J.; Mendelev, M. I.; Wang, C. Z.; Napolitano, R. E.; Ho, K. M.

2017-10-01

Investigating the unknown structure of the complex cubic phase, previously observed to crystallize from melt-spun amorphous Al-10 at.% Sm alloy, we determine the structure in full site-occupancy detail, highlighting several critical structural features that govern the far-from-equilibrium phase selection pathway. Using an efficient genetic algorithm combining molecular dynamics, density functional theory, and x-ray diffraction, the structure is clearly identified as body-centered cubic I m 3 ¯m (No. 229) with ˜140 atoms per cubic unit cell and a lattice parameter of 1.4 nm. The complex structure is further refined to elucidate the detailed site occupancy, revealing full Sm occupancy on 6b sites and split Sm/Al occupancy on 16f sites. Based on the refined site occupancy associated with the experimentally observed phase, we term this phase ɛ -A l60S m11 (bcc), corresponding to the limiting situation when all 16f sites are occupied by Sm. However, it should be recognized that the range of solubility enabled by split occupancy at Sm sites is an important feature in phase selection under experimental conditions, permitting an avenue for transition with little or no chemical partitioning. Our analysis shows that the ɛ -A l60S m11 (bcc) exhibits a "3-6-6-1" first-shell packing around Sm centers on 16f sites, the same dominant motif exhibited by the undercooled liquid. The coincident motif supports the notion that liquid/glass ordering at high undercooling may give rise to topological invariants between the noncrystalline and crystalline states that provide kinetic pathways to metastable phases that are not accessible during near-equilibrium processing.

Structural hierarchy as a key to complex phase selection in Al-Sm

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ye, Z.; Zhang, F.; Sun, Y.

Investigating the unknown structure of the complex cubic phase, previously observed to crystallize from melt-spun amorphous Al–10 at.% Sm alloy, we determine the structure in full site-occupancy detail, highlighting several critical structural features that govern the far-from-equilibrium phase selection pathway. Using an efficient genetic algorithm combining molecular dynamics, density functional theory, and x-ray diffraction, the structure is clearly identified as body-centered cubic Im¯3m (No. 229) with ~140 atoms per cubic unit cell and a lattice parameter of 1.4 nm. The complex structure is further refined to elucidate the detailed site occupancy, revealing full Sm occupancy on 6b sites and splitmore » Sm/Al occupancy on 16f sites. Based on the refined site occupancy associated with the experimentally observed phase, we term this phase ε–Al 60Sm 11(bcc), corresponding to the limiting situation when all 16f sites are occupied by Sm. However, it should be recognized that the range of solubility enabled by split occupancy at Sm sites is an important feature in phase selection under experimental conditions, permitting an avenue for transition with little or no chemical partitioning. Our analysis shows that the ε–Al 60Sm 11(bcc) exhibits a “3-6-6-1” first-shell packing around Sm centers on 16f sites, the same dominant motif exhibited by the undercooled liquid. Here, the coincident motif supports the notion that liquid/glass ordering at high undercooling may give rise to topological invariants between the noncrystalline and crystalline states that provide kinetic pathways to metastable phases that are not accessible during near-equilibrium processing.« less

Structural hierarchy as a key to complex phase selection in Al-Sm

DOE PAGES

Ye, Z.; Zhang, F.; Sun, Y.; ...

2017-10-12

Investigating the unknown structure of the complex cubic phase, previously observed to crystallize from melt-spun amorphous Al–10 at.% Sm alloy, we determine the structure in full site-occupancy detail, highlighting several critical structural features that govern the far-from-equilibrium phase selection pathway. Using an efficient genetic algorithm combining molecular dynamics, density functional theory, and x-ray diffraction, the structure is clearly identified as body-centered cubic Im¯3m (No. 229) with ~140 atoms per cubic unit cell and a lattice parameter of 1.4 nm. The complex structure is further refined to elucidate the detailed site occupancy, revealing full Sm occupancy on 6b sites and splitmore » Sm/Al occupancy on 16f sites. Based on the refined site occupancy associated with the experimentally observed phase, we term this phase ε–Al 60Sm 11(bcc), corresponding to the limiting situation when all 16f sites are occupied by Sm. However, it should be recognized that the range of solubility enabled by split occupancy at Sm sites is an important feature in phase selection under experimental conditions, permitting an avenue for transition with little or no chemical partitioning. Our analysis shows that the ε–Al 60Sm 11(bcc) exhibits a “3-6-6-1” first-shell packing around Sm centers on 16f sites, the same dominant motif exhibited by the undercooled liquid. Here, the coincident motif supports the notion that liquid/glass ordering at high undercooling may give rise to topological invariants between the noncrystalline and crystalline states that provide kinetic pathways to metastable phases that are not accessible during near-equilibrium processing.« less

Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A.

PubMed

Howard, E I; Sanishvili, R; Cachau, R E; Mitschler, A; Chevrier, B; Barth, P; Lamour, V; Van Zandt, M; Sibley, E; Bon, C; Moras, D; Schneider, T R; Joachimiak, A; Podjarny, A

2004-06-01

The first subatomic resolution structure of a 36 kDa protein [aldose reductase (AR)] is presented. AR was cocrystallized at pH 5.0 with its cofactor NADP+ and inhibitor IDD 594, a therapeutic candidate for the treatment of diabetic complications. X-ray diffraction data were collected up to 0.62 A resolution and treated up to 0.66 A resolution. Anisotropic refinement followed by a blocked matrix inversion produced low standard deviations (<0.005 A). The model was very well ordered overall (CA atoms' mean B factor is 5.5 A2). The model and the electron-density maps revealed fine features, such as H-atoms, bond densities, and significant deviations from standard stereochemistry. Other features, such as networks of hydrogen bonds (H bonds), a large number of multiple conformations, and solvent structure were also better defined. Most of the atoms in the active site region were extremely well ordered (mean B approximately 3 A2), leading to the identification of the protonation states of the residues involved in catalysis. The electrostatic interactions of the inhibitor's charged carboxylate head with the catalytic residues and the charged coenzyme NADP+ explained the inhibitor's noncompetitive character. Furthermore, a short contact involving the IDD 594 bromine atom explained the selectivity profile of the inhibitor, important feature to avoid toxic effects. The presented structure and the details revealed are instrumental for better understanding of the inhibition mechanism of AR by IDD 594, and hence, for the rational drug design of future inhibitors. This work demonstrates the capabilities of subatomic resolution experiments and stimulates further developments of methods allowing the use of the full potential of these experiments. Copyright 2004 Wiley-Liss, Inc.

Tuning transport properties on graphene multiterminal structures by mechanical deformations

NASA Astrophysics Data System (ADS)

Latge, Andrea; Torres, Vanessa; Faria, Daiara

The realization of mechanical strain on graphene structures is viewed as a promise route to tune electronic and transport properties such as changing energy band-gaps and promoting localization of states. Using continuum models, mechanical deformations are described by effective gauge fields, mirrored as pseudomagnetic fields that may reach quite high values. Interesting symmetry features are developed due to out of plane deformations on graphene; lift sublattice symmetry was predicted and observed in centrosymmetric bumps and strained nanobubbles. Here we discuss the effects of Gaussian-like strain on a hexagonal graphene flake connected to three leads, modeled as perfect graphene nanoribbons. The Green function formalism is used within a tight-binding approximation. For this particular deformation sharp resonant states are achieved depending on the strained structure details. We also study a fold-strained structure in which the three leads are deformed extending up to the very center of the hexagonal flake. We show that conductance suppressions can be controlled by the strain intensity and important transport features are modeled by the electronic band structure of the leads.

New Features in the Lipid A Structure of Brucella suis and Brucella abortus Lipopolysaccharide

NASA Astrophysics Data System (ADS)

Casabuono, Adriana C.; Czibener, Cecilia; Del Giudice, Mariela G.; Valguarnera, Ezequiel; Ugalde, Juan E.; Couto, Alicia S.

2017-12-01

Brucellaceae are Gram-negative bacteria that cause brucellosis, one of the most distributed worldwide zoonosis, transmitted to humans by contact with either infected animals or their products. The lipopolysaccharide exposed on the cell surface has been intensively studied and is considered a major virulence factor of Brucella. In the last years, structural studies allowed the determination of new structures in the core oligosaccharide and the O-antigen of this lipopolysaccharide. In this work, we have reinvestigated the lipid A structure isolated from B. suis and B. abortus lipopolysaccharides. A detailed study by MALDI-TOF mass spectrometry in the positive and negative ion modes of the lipid A moieties purified from both species was performed. Interestingly, a new feature was detected: the presence of a pyrophosphorylethanolamine residue substituting the backbone. LID-MS/MS analysis of some of the detected ions allowed assurance that the Lipid A structure composed by the diGlcN3N disaccharide, mainly hexa-acylated and penta-acylated, bearing one phosphate and one pyrophosphorylethanolamine residue. [Figure not available: see fulltext.

New Features in the Lipid A Structure of Brucella suis and Brucella abortus Lipopolysaccharide.

PubMed

Casabuono, Adriana C; Czibener, Cecilia; Del Giudice, Mariela G; Valguarnera, Ezequiel; Ugalde, Juan E; Couto, Alicia S

2017-12-01

Brucellaceae are Gram-negative bacteria that cause brucellosis, one of the most distributed worldwide zoonosis, transmitted to humans by contact with either infected animals or their products. The lipopolysaccharide exposed on the cell surface has been intensively studied and is considered a major virulence factor of Brucella. In the last years, structural studies allowed the determination of new structures in the core oligosaccharide and the O-antigen of this lipopolysaccharide. In this work, we have reinvestigated the lipid A structure isolated from B. suis and B. abortus lipopolysaccharides. A detailed study by MALDI-TOF mass spectrometry in the positive and negative ion modes of the lipid A moieties purified from both species was performed. Interestingly, a new feature was detected: the presence of a pyrophosphorylethanolamine residue substituting the backbone. LID-MS/MS analysis of some of the detected ions allowed assurance that the Lipid A structure composed by the diGlcN3N disaccharide, mainly hexa-acylated and penta-acylated, bearing one phosphate and one pyrophosphorylethanolamine residue. Graphical abstract ᅟ.

Ion Spectral Structures Observed by the Van Allen Probes and Cluster

NASA Astrophysics Data System (ADS)

Ferradas, C.; Zhang, J.; Luo, H.; Kistler, L. M.; Spence, H. E.; Larsen, B.; Skoug, R. M.; Funsten, H. O.; Reeves, G. D.

2014-12-01

During the last decades several missions have recorded the presence of dynamic spectral features of energetic ions in the inner magnetosphere. Previous studies have revealed single "nose-like" structures occurring alone and simultaneous nose-like structures (up to three). In this study we also include signatures of new types of ion structure, namely "trunk-like" and "tusk-like" structures. All the ion structures are named after the characteristic shapes of energy bands or gaps in the energy-time spectrograms of in situ measured ion fluxes. They constitute the observational signatures of ion acceleration, transport, and loss in the global magnetosphere. Multi-spacecraft analysis of these structures is important to understand their spatial distribution and temporal evolution. Mass spectrometers onboard Cluster (in a polar orbit) and the Van Allen Probes (in an equatorial orbit) measure energetic hydrogen, helium, and oxygen ions near the inner edge of the plasma sheet, where these ion structures are observed. We present a statistical study of the ion structures, using >1-year measurements from the two missions during the Van Allen Probes era. The results provide important details about the spatial distribution (dependence on geocentric distance and magnetic local time), spectral features of the structures (e.g., characteristic energy and differences among species), and geomagnetic and solar wind conditions under which these structures occur.

Using Multispectral False Color Imaging to Characterize Tropical Cyclone Structure and Environment

NASA Astrophysics Data System (ADS)

Cossuth, J.; Bankert, R.; Richardson, K.; Surratt, M. L.

2016-12-01

The Naval Research Laboratory's (NRL) tropical cyclone (TC) web page (http://www.nrlmry.navy.mil/TC.html) has provided nearly two decades of near real-time access to TC-centric images and products by TC forecasters and enthusiasts around the world. Particularly, microwave imager and sounder information that is featured on this site provides crucial internal storm structure information by allowing users to perceive hydrometeor structure, providing key details beyond cloud top information provided by visible and infrared channels. Towards improving TC analysis techniques and helping advance the utility of the NRL TC webpage resource, new research efforts are presented. This work demonstrates results as well as the methodology used to develop new automated, objective satellite-based TC structure and intensity guidance and enhanced data fusion imagery products that aim to bolster and streamline TC forecast operations. This presentation focuses on the creation and interpretation of false color RGB composite imagery that leverages the different emissive and scattering properties of atmospheric ice, liquid, and vapor water as well as ocean surface roughness as seen by microwave radiometers. Specifically, a combination of near-realtime data and a standardized digital database of global TCs in microwave imagery from 1987-2012 is employed as a climatology of TC structures. The broad range of TC structures, from pinhole eyes through multiple eyewall configurations, is characterized as resolved by passive microwave sensors. The extraction of these characteristic features from historical data also lends itself to statistical analysis. For example, histograms of brightness temperature distributions allows a rigorous examination of how structural features are conveyed in image products, allowing a better representation of colors and breakpoints as they relate to physical features. Such climatological work also suggests steps to better inform the near-real time application of upcoming satellite datasets to TC analyses.

Distributed computer taxonomy based on O/S structure

NASA Technical Reports Server (NTRS)

Foudriat, Edwin C.

1985-01-01

The taxonomy considers the resource structure at the operating system level. It compares a communication based taxonomy with the new taxonomy to illustrate how the latter does a better job when related to the client's view of the distributed computer. The results illustrate the fundamental features and what is required to construct fully distributed processing systems. The problem of using network computers on the space station is addressed. A detailed discussion of the taxonomy is not given here. Information is given in the form of charts and diagrams that were used to illustrate a talk.

Photoluminescence Mapping and Angle-Resolved Photoluminescence of MBE-Grown InGaAs/GaAs RC LED and VCSEL Structures

DTIC Science & Technology

2002-06-03

resonant-cavity light-emitting diodes (RC LEDs) and vertical-cavity surface-emitting lasers ( VCSELs )] fabricated from molecular beam epitaxy (MBE)-grown...grown 8470-631. by molecular beam epitaxy (MBE) using a Riber 32P E-mail address: muszal@ite.waw.pl (0. Muszalski). reactor. Details of the growth can be... molecular beams hit the center of a rotating sion features of RC LED and VCSEL structures, as well sample. However, due to the transversal distribution of as

Selecting a Persistent Data Support Environment for Object-Oriented Applications

DTIC Science & Technology

1998-03-01

key features of most object DBMS products is contained in the <DWAS 9{eeds Assessment for Objects from Barry and Associates. The developer should...data structure and behavior in a self- contained module enhances maintainability of the system and promotes reuse of modules for similar domains...considered together, represent a survey of commercial object-oriented database management systems. These references contain detailed information needed

Working Memory & Augmented Reality's Trajectory: A Literature Review of AR in Education, Online Learning, Workforce Training, and Working Memory Research

ERIC Educational Resources Information Center

Squires, David R.

2017-01-01

The structure of the literature review features the current trajectory of Augmented Reality in the field including the current literature detailing how Augmented Reality has been applied in educational environments; how Augmented Reality has been applied in training environments; how Augmented Reality has been used to measure cognition and the…

Examination of Bursty Electromagnetic Waves Observed During Intervals of Turbulent Magnetosheath Reconnection

NASA Technical Reports Server (NTRS)

Adrian, Mark L.; Wendel, D. E.

2011-01-01

We investigate observations of intense bursts of electromagnetic waves in association with magnetic reconnection in the turbulent magnetosheath. These structured, broadband bursts occur above 80-Hz, often displaying features reminiscent of absorption bands and are observed at local minima in the magnetic field. We present detailed analyses of these intense bursts of electromagnetic waves and quantify their proximity to X- and O-nulls.

Coherent perfect rotation theory: connections with, and consequences beyond, the anti-laser

NASA Astrophysics Data System (ADS)

Crescimanno, Michael; Andrews, James; Zhou, Chuanhong; Baker, Michael

2014-05-01

Coherent Perfect Rotation (CPR) phenomena are a reversible generalization of the anti-laser. By evaluating CPR in a broad variety of common optical systems, including optical cavities and DFB and DBR structures, we illustrate its unique threshold and resonance features. This study builds intuition critical to assessing the utility of CPR in optical devices, and we detail it in a concrete application.

Structural characterization by cross-linking reveals the detailed architecture of a coatomer-related heptameric module from the nuclear pore complex.

PubMed

Shi, Yi; Fernandez-Martinez, Javier; Tjioe, Elina; Pellarin, Riccardo; Kim, Seung Joong; Williams, Rosemary; Schneidman-Duhovny, Dina; Sali, Andrej; Rout, Michael P; Chait, Brian T

2014-11-01

Most cellular processes are orchestrated by macromolecular complexes. However, structural elucidation of these endogenous complexes can be challenging because they frequently contain large numbers of proteins, are compositionally and morphologically heterogeneous, can be dynamic, and are often of low abundance in the cell. Here, we present a strategy for the structural characterization of such complexes that has at its center chemical cross-linking with mass spectrometric readout. In this strategy, we isolate the endogenous complexes using a highly optimized sample preparation protocol and generate a comprehensive, high-quality cross-linking dataset using two complementary cross-linking reagents. We then determine the structure of the complex using a refined integrative method that combines the cross-linking data with information generated from other sources, including electron microscopy, X-ray crystallography, and comparative protein structure modeling. We applied this integrative strategy to determine the structure of the native Nup84 complex, a stable hetero-heptameric assembly (∼ 600 kDa), 16 copies of which form the outer rings of the 50-MDa nuclear pore complex (NPC) in budding yeast. The unprecedented detail of the Nup84 complex structure reveals previously unseen features in its pentameric structural hub and provides information on the conformational flexibility of the assembly. These additional details further support and augment the protocoatomer hypothesis, which proposes an evolutionary relationship between vesicle coating complexes and the NPC, and indicates a conserved mechanism by which the NPC is anchored in the nuclear envelope. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Volumetric quantitative characterization of human patellar cartilage with topological and geometrical features on phase-contrast X-ray computed tomography.

PubMed

Nagarajan, Mahesh B; Coan, Paola; Huber, Markus B; Diemoz, Paul C; Wismüller, Axel

2015-11-01

Phase-contrast X-ray computed tomography (PCI-CT) has attracted significant interest in recent years for its ability to provide significantly improved image contrast in low absorbing materials such as soft biological tissue. In the research context of cartilage imaging, previous studies have demonstrated the ability of PCI-CT to visualize structural details of human patellar cartilage matrix and capture changes to chondrocyte organization induced by osteoarthritis. This study evaluates the use of geometrical and topological features for volumetric characterization of such chondrocyte patterns in the presence (or absence) of osteoarthritic damage. Geometrical features derived from the scaling index method (SIM) and topological features derived from Minkowski Functionals were extracted from 1392 volumes of interest (VOI) annotated on PCI-CT images of ex vivo human patellar cartilage specimens. These features were subsequently used in a machine learning task with support vector regression to classify VOIs as healthy or osteoarthritic; classification performance was evaluated using the area under the receiver operating characteristic curve (AUC). Our results show that the classification performance of SIM-derived geometrical features (AUC: 0.90 ± 0.09) is significantly better than Minkowski Functionals volume (AUC: 0.54 ± 0.02), surface (AUC: 0.72 ± 0.06), mean breadth (AUC: 0.74 ± 0.06) and Euler characteristic (AUC: 0.78 ± 0.04) (p < 10(-4)). These results suggest that such geometrical features can provide a detailed characterization of the chondrocyte organization in the cartilage matrix in an automated manner, while also enabling classification of cartilage as healthy or osteoarthritic with high accuracy. Such features could potentially serve as diagnostic imaging markers for evaluating osteoarthritis progression and its response to different therapeutic intervention strategies.

The observed life cycle of a baroclinic instability

NASA Technical Reports Server (NTRS)

Randel, W. J.; Stanford, J. L.

1985-01-01

Medium-scale waves (zonal wavenumbers 4-7) frequently dominate Southern Hemisphere summer circulation patterns. Randel and Stanford have studied the dynamics of these features, demonstrating that the medium-scale waves result from baroclinic excitation and exhibit well-defined life cycles. This study details the evolution of the medium-scale waves during a particular life cycle. The specific case chosen exhibits a high degree of zonal symmetry, prompting study based upon zonally averaged diagnostics. An analysis of the medium-scale wave energetics reveals a well-defined life cycle of baroclinic growth, maturity, and barotropic decay. Eliassen-Palm flux diagrams detail the daily wave structure and its interaction with the zonally-averaged flow.

A robust automated system elucidates mouse home cage behavioral structure

PubMed Central

Goulding, Evan H.; Schenk, A. Katrin; Juneja, Punita; MacKay, Adrienne W.; Wade, Jennifer M.; Tecott, Laurence H.

2008-01-01

Patterns of behavior exhibited by mice in their home cages reflect the function and interaction of numerous behavioral and physiological systems. Detailed assessment of these patterns thus has the potential to provide a powerful tool for understanding basic aspects of behavioral regulation and their perturbation by disease processes. However, the capacity to identify and examine these patterns in terms of their discrete levels of organization across diverse behaviors has been difficult to achieve and automate. Here, we describe an automated approach for the quantitative characterization of fundamental behavioral elements and their patterns in the freely behaving mouse. We demonstrate the utility of this approach by identifying unique features of home cage behavioral structure and changes in distinct levels of behavioral organization in mice with single gene mutations altering energy balance. The robust, automated, reproducible quantification of mouse home cage behavioral structure detailed here should have wide applicability for the study of mammalian physiology, behavior, and disease. PMID:19106295

Facilitating the exploitation of ERTS imagery using snow enhancement techniques

NASA Technical Reports Server (NTRS)

Wobber, F. J. (Principal Investigator); Martin, K. R.; Amato, R. V.

1973-01-01

The author has identified the following significant results. New fracture detail within New England test area has been interpreted from ERTS-1 images. Comparative analysis of snow-free imagery (1096-15065 and 1096-15072) has demonstrated that MSS bands 5 and 7 supply the greatest amount of geological fracture detail. Interpretation of the first snow-covered ERTS-1 images (1132-15074 and 1168-15065) in correlation with ground snow depth data indicates that a heavy blanket of snow (less than 9 inches) accentuates major structural features while a light dusting (greater than 1 inch) accentuates more subtle topographic expressions. Snow cover was found to accentuate drainage patterns which are indicative of lithological and/or structural variations. Snow cover provided added enhancement for viewing and detecting topographically expressed fractures and faults. A recent field investigation was conducted within the New England test area to field check lineaments observed from analysis of ERTS-1 imagery, collect snow depth readings, and obtain structural joint readings at key locations in the test area.

Relationship of Interplanetary Shock Micro and Macro Characteristics: A Wind Study

NASA Technical Reports Server (NTRS)

Szabo, Adam; Koval, A

2008-01-01

The non-linear least squared MHD fitting technique of Szabo 11 9941 has been recently further refined to provide realistic confidence regions for interplanetary shock normal directions and speeds. Analyzing Wind observed interplanetary shocks from 1995 to 200 1, macro characteristics such as shock strength, Theta Bn and Mach numbers can be compared to the details of shock micro or kinetic structures. The now commonly available very high time resolution (1 1 or 22 vectors/sec) Wind magnetic field data allows the precise characterization of shock kinetic structures, such as the size of the foot, ramp, overshoot and the duration of damped oscillations on either side of the shock. Detailed comparison of the shock micro and macro characteristics will be given. This enables the elucidation of shock kinetic features, relevant for particle energization processes, for observations where high time resolution data is not available. Moreover, establishing a quantitative relationship between the shock micro and macro structures will improve the confidence level of shock fitting techniques during disturbed solar wind conditions.

Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes.

PubMed

Grochowski, Christopher M; Gu, Shen; Yuan, Bo; Tcw, Julia; Brennand, Kristen J; Sebat, Jonathan; Malhotra, Dheeraj; McCarthy, Shane; Rudolph, Uwe; Lindstrand, Anna; Chong, Zechen; Levy, Deborah L; Lupski, James R; Carvalho, Claudia M B

2018-04-25

Small supernumerary marker chromosomes (sSMC) are chromosomal fragments difficult to characterize genomically. Here, we detail a proband with schizoaffective disorder and a mother with bipolar disorder with psychotic features who present with a marker chromosome that segregates with disease. We explored the architecture of this marker and investigated its temporal origin. Array comparative genomic hybridization (aCGH) analysis revealed three duplications and three triplications that spanned the short arm of chromosome 9, suggestive of a chromoanasynthesis-like event. Segregation of marker genotypes, phased using sSMC mosaicism in the mother, provided evidence that it was generated during a germline-level event in the proband's maternal grandmother. Whole-genome sequencing (WGS) was performed to resolve the structure and junctions of the chromosomal fragments, revealing further complexities. While structural variations have been previously associated with neuropsychiatric disorders and marker chromosomes, here we detail the precise architecture, human life-cycle genesis, and propose a DNA replicative/repair mechanism underlying formation. © 2018 Wiley Periodicals, Inc.

Interdisciplinary applications and interpretations of ERTS data within the Susquehanna River basin

NASA Technical Reports Server (NTRS)

Mcmurtry, G. J.; Petersen, G. W. (Principal Investigator)

1975-01-01

The author has identified the following significant results. The full potential of high quality data is achieved only with the application of efficient and effective interpretation techniques. An excellent operating system for handling, processing, and interpreting ERTS-1 and other MSS data was achieved. Programs for processing digital data are implemented on a large nondedicated general purpose computer. Significant results were attained in mapping land use, agricultural croplands, forest resources, and vegetative cover. Categories of land use classified and mapped depend upon the geographic location, the detail required, and the types of lands use of interest. Physiographic and structural provinces are spectacularly displayed on ERTS-1 MSS image mosaics. Geologic bedrock structures show up well and formation contacts can sometimes be traced for hundreds of kilometers. Large circular structures and regional features, previously obscured by the detail of higher resolution data, can be seen. Environmental monitoring was performed in three areas: coal strip mining, coal refuse problems, and damage to vegetation caused by insects and pollution.

Teaching structure: student use of software tools for understanding macromolecular structure in an undergraduate biochemistry course.

PubMed

Jaswal, Sheila S; O'Hara, Patricia B; Williamson, Patrick L; Springer, Amy L

2013-01-01

Because understanding the structure of biological macromolecules is critical to understanding their function, students of biochemistry should become familiar not only with viewing, but also with generating and manipulating structural representations. We report a strategy from a one-semester undergraduate biochemistry course to integrate use of structural representation tools into both laboratory and homework activities. First, early in the course we introduce the use of readily available open-source software for visualizing protein structure, coincident with modules on amino acid and peptide bond properties. Second, we use these same software tools in lectures and incorporate images and other structure representations in homework tasks. Third, we require a capstone project in which teams of students examine a protein-nucleic acid complex and then use the software tools to illustrate for their classmates the salient features of the structure, relating how the structure helps explain biological function. To ensure engagement with a range of software and database features, we generated a detailed template file that can be used to explore any structure, and that guides students through specific applications of many of the software tools. In presentations, students demonstrate that they are successfully interpreting structural information, and using representations to illustrate particular points relevant to function. Thus, over the semester students integrate information about structural features of biological macromolecules into the larger discussion of the chemical basis of function. Together these assignments provide an accessible introduction to structural representation tools, allowing students to add these methods to their biochemical toolboxes early in their scientific development. © 2013 by The International Union of Biochemistry and Molecular Biology.

Using Selective Drainage Methods to Extract Continuous Surface Flow from 1-Meter Lidar-Derived Digital Elevation Data

USGS Publications Warehouse

Poppenga, Sandra K.; Worstell, Bruce B.; Stoker, Jason M.; Greenlee, Susan K.

2010-01-01

Digital elevation data commonly are used to extract surface flow features. One source for high-resolution elevation data is light detection and ranging (lidar). Lidar can capture a vast amount of topographic detail because of its fine-scale ability to digitally capture the surface of the earth. Because elevation is a key factor in extracting surface flow features, high-resolution lidar-derived digital elevation models (DEMs) provide the detail needed to consistently integrate hydrography with elevation, land cover, structures, and other geospatial features. The U.S. Geological Survey has developed selective drainage methods to extract continuous surface flow from high-resolution lidar-derived digital elevation data. The lidar-derived continuous surface flow network contains valuable information for water resource management involving flood hazard mapping, flood inundation, and coastal erosion. DEMs used in hydrologic applications typically are processed to remove depressions by filling them. High-resolution DEMs derived from lidar can capture much more detail of the land surface than courser elevation data. Therefore, high-resolution DEMs contain more depressions because of obstructions such as roads, railroads, and other elevated structures. The filling of these depressions can significantly affect the DEM-derived surface flow routing and terrain characteristics in an adverse way. In this report, selective draining methods that modify the elevation surface to drain a depression through an obstruction are presented. If such obstructions are not removed from the elevation data, the filling of depressions to create continuous surface flow can cause the flow to spill over an obstruction in the wrong location. Using this modified elevation surface improves the quality of derived surface flow and retains more of the true surface characteristics by correcting large filled depressions. A reliable flow surface is necessary for deriving a consistently connected drainage network, which is important in understanding surface water movement and developing applications for surface water runoff, flood inundation, and erosion. Improved methods are needed to extract continuous surface flow features from high-resolution elevation data based on lidar.

Evaluation of normal findings using a detailed and focused technique for transcutaneous abdominal ultrasonography in the horse

PubMed Central

2014-01-01

Background Ultrasonography is an important diagnostic tool in the investigation of abdominal disease in the horse. Several factors may affect the ability to image different structures within the abdomen. The aim of the study was to describe the repeatability of identification of abdominal structures in normal horses using a detailed ultrasonographic examination technique and using a focused, limited preparation technique. Methods A detailed abdominal ultrasound examination was performed in five normal horses, repeated on five occasions (total of 25 examinations). The abdomen was divided into ten different imaging sites, and structures identified in each site were recorded. Five imaging sites were then selected for a single focused ultrasound examination in 20 normal horses. Limited patient preparation was performed. Structures were recorded as ‘identified’ if ultrasonographic features could be distinguished. The location of organs and their frequency of identification were recorded. Data from both phases were analysed to determine repeatability of identification of structures in each examination (irrespective of imaging site), and for each imaging site. Results Caecum, colon, spleen, liver and right kidney were repeatably identified using the detailed technique, and had defined locations. Large colon and right kidney were identified in 100% of examinations with both techniques. Liver, spleen, caecum, duodenum and other small intestine were identified more frequently with the detailed examination. Small intestine was most frequently identified in the ventral abdomen, its identification varied markedly within and between horses, and required repeated examinations in some horses. Left kidney could not be identified in every horse using either technique. Sacculated colon was identified in all ventral sites, and was infrequently identified in dorsal sites. Conclusions Caecum, sacculated large intestine, spleen, liver and right kidney were consistently identified with both techniques. There were some normal variations which should be considered when interpreting ultrasonographic findings in clinical cases: left kidney was not always identified, sacculated colon was occasionally identified in dorsal flank sites. Multiple imaging sites and repeated examinations may be required to identify small intestine. A focused examination identified most key structures, but has some limitations compared to a detailed examination. PMID:25238559

The velocity field of a coronal mass ejection - The event of September 1, 1980

NASA Technical Reports Server (NTRS)

Low, B. C.; Hundhausen, A. J.

1987-01-01

The velocity field of a mass ejection that was observed by the coronagraph of the SMM satellite over the northwest limb of the sun at about 0600 UT on September 1, 1980 is studied in detail. A descriptive account of the event is given, concentrating on qualitative features of the mass motion and suggesting a possible origin of the unusual two-loop structure. The velocity field is analyzed quantitatively, and the implications of the results for the mass ejection theory are considered. It is concluded that a self-similar description of the velocity field is a gross oversimplification and that although some evidence of wave propagation can be found, the bright features in the mass ejection are plasma structures moving with frozen-in magnetic fields, rather than waves propagating through plasmas and magnetic fields.

Airborne laser swath mapping of the Denton Hills, Transantarctic Mountains, Antarctica: Applications for structural and glacial geomorphic mapping

USGS Publications Warehouse

Wilson, Terry; Csathó, Beata

2007-01-01

High-resolution digital elevation data acquired by airborne laser scanning (ALS) for the Denton Hills, along the coastal foothills of the Royal Society Range, Transantarctic Mountains, are examined for applications to bedrock and glacial geomorphic mapping. Digital elevation models (DEMs), displayed as shaded-relief images and slope maps, portray geomorphic landscape features in unprecedented detail across the region. Structures of both ductile and brittle origin, ranging in age from the Paleozoic to the Quaternary, can be mapped from the DEMs. Glacial features, providing a record of the limits of grounded ice, of lake paleoshorelines, and of proglacial lake-ice conveyor deposits, are also prominent on the DEMs. The ALS-derived topographic data have great potential for a range of mapping applications in regions of ice-free terrain in Antarctica

Nuclear Physics Around the Unitarity Limit

DOE PAGES

König, Sebastian; Grießhammer, Harald W.; Hammer, H. -W.; ...

2017-05-15

We argue that many features of the structure of nuclei emerge from a strictly perturbative expansion around the unitarity limit, where the two-nucleon S waves have bound states at zero energy. In this limit, the gross features of states in the nuclear chart are correlated to only one dimensionful parameter, which is related to the breaking of scale invariance to a discrete scaling symmetry and set by the triton binding energy. Observables are moved to their physical values by small perturbative corrections, much like in descriptions of the fine structure of atomic spectra. We provide evidence in favor of themore » conjecture that light, and possibly heavier, nuclei are bound weakly enough to be insensitive to the details of the interactions but strongly enough to be insensitive to the exact size of the two-nucleon system.« less

Shock Structure Analysis and Aerodynamics in a Weakly Ionized Gas Flow

NASA Technical Reports Server (NTRS)

Saeks, R.; Popovic, S.; Chow, A. S.

2006-01-01

The structure of a shock wave propagating through a weakly ionized gas is analyzed using an electrofluid dynamics model composed of classical conservation laws and Gauss Law. A viscosity model is included to correctly model the spatial scale of the shock structure, and quasi-neutrality is not assumed. A detailed analysis of the structure of a shock wave propagating in a weakly ionized gas is presented, together with a discussion of the physics underlying the key features of the shock structure. A model for the flow behind a shock wave propagating through a weakly ionized gas is developed and used to analyze the effect of the ionization on the aerodynamics and performance of a two-dimensional hypersonic lifting body.

Looking at tardigrades in a new light: using epifluorescence to interpret structure.

PubMed

Perry, E S; Miller, W R; Lindsay, S

2015-02-01

The use of epifluorescence microscopy coupled with ultraviolet (UV) autofluorescence is suggested as a means to view and interpret tardigrade structures. Endogenous fluorochromes are a known component of tardigrade cuticle, claws and bucco-pharyngeal apparatus. By imaging the autofluorescence from tardigrades, it is possible to document these structures in detail, including the subdivisions and boundaries of echiniscid (heterotardigrade) plates and the nature and spatial relationships of the texture (pores, granules, papillae and tubercles) on the various plates. This allows the determination of taxonomic features not easily seen with other microscopic techniques. © 2014 The Authors Journal of Microscopy © 2014 Royal Microscopical Society.

The versatility of a truss mounted mobile transporter for in-space construction

NASA Technical Reports Server (NTRS)

Bush, Harold G.; Lake, Mark S.; Watson, Judith J.; Heard, Walter L., Jr.

1988-01-01

The Mobile Transporter (MT) evolution from early erectable structures assembly activities is detailed. The MT operational features which are required to support astronauts performing on-orbit structure construction or spacecraft assembly functions are presented and discussed. Use of the MT to perform a variety of assembly functions is presented. Estimated EVA assembly times for a precision segmented reflector approximately 20 m in diameter are presented. The EVA/MT technique under study for construction of the reflector (and the entire spacecraft) is illustrated. Finally, the current status of development activities and test results involving the MT and Space Station structural assembly are presented.

Neutron Structure of Human Carbonic Anhydrase II: Implications for Proton Transfer†

PubMed Central

Fisher, S. Zoë; Kovalevsky, Andrey Y.; Domsic, John F.; Mustyakimov, Marat; McKenna, Robert; Silverman, David N.; Langan, Paul A.

2010-01-01

Human carbonic anhydrase II (HCA II) catalyzes the reversible hydration of carbon dioxide to form bicarbonate and a proton. Despite many high-resolution X-ray crystal structures, mutagenesis, and kinetic data, the structural details of the active site, especially the proton transfer pathway, are unclear. A large HCA II crystal was prepared at pH 9.0 and subjected to vapor H–D exchange to replace labile hydrogens with deuteriums. Neutron diffraction studies were conducted at the Protein Crystallography Station at Los Alamos National Laboratory. The structure to 2.0 Å resolution reveals several interesting active site features: (1) the Zn-bound solvent appearing to be predominantly a D2O molecule, (2) the orientation and hydrogen bonding pattern of solvent molecules in the active site cavity, (3) the side chain of His64 being unprotonated (neutral) and predominantly in an inward conformation pointing toward the zinc, and (4) the phenolic side chain of Tyr7 appearing to be unprotonated. The implications of these details are discussed, and a proposed mechanism for proton transfer is presented. PMID:20025241

The effect of magnesium ions on chromosome structure as observed by helium ion microscopy.

PubMed

Dwiranti, Astari; Hamano, Tohru; Takata, Hideaki; Nagano, Shoko; Guo, Hongxuan; Onishi, Keiko; Wako, Toshiyuki; Uchiyama, Susumu; Fukui, Kiichi

2014-02-01

One of the few conclusions known about chromosome structure is that Mg2+ is required for the organization of chromosomes. Scanning electron microscopy is a powerful tool for studying chromosome morphology, but being nonconductive, chromosomes require metal/carbon coating that may conceal information about the detailed surface structure of the sample. Helium ion microscopy (HIM), which has recently been developed, does not require sample coating due to its charge compensation system. Here we investigated the structure of isolated human chromosomes under different Mg2+ concentrations by HIM. High-contrast and resolution images from uncoated samples obtained by HIM enabled investigation on the effects of Mg2+ on chromosome structure. Chromatin fiber information was obtained more clearly with uncoated than coated chromosomes. Our results suggest that both overall features and detailed structure of chromatin are significantly affected by different Mg2+ concentrations. Chromosomes were more condensed and a globular structure of chromatin with 30 nm diameter was visualized with 5 mM Mg2+ treatment, while 0 mM Mg2+ resulted in a less compact and more fibrous structure 11 nm in diameter. We conclude that HIM is a powerful tool for investigating chromosomes and other biological samples without requiring metal/carbon coating.

Structural features, substrate specificity, kinetic properties of insect α-amylase and specificity of plant α-amylase inhibitors.

PubMed

Kaur, Rimaljeet; Kaur, Narinder; Gupta, Anil Kumar

2014-11-01

α-Amylase is an important digestive enzyme required for the optimal growth and development of insects. Several insect α-amylases had been purified and their physical and chemical properties were characterized. Insect α-amylases of different orders display variability in structure, properties and substrate specificity. Such diverse properties of amylases could be due to different feeding habits and gut environment of insects. In this review, structural features and properties of several insect α-amylases were compared. This could be helpful in exploring the diversity in characteristics of α-amylase between the members of the same class (insecta). Properties like pH optima are reflected in enzyme structural features. In plants, α-amylase inhibitors (α-AIs) occur as part of natural defense mechanisms against pests by interfering in their digestion process and thus could also provide access to new pest management strategies. AIs are quite specific in their action; therefore, these could be employed according to their effectiveness against target amylases. Potential of transgenics with α-AIs has also been discussed for insect resistance and controlling infestation. The differences in structural features of insect α-amylases provided reasons for their efficient functioning at different pH and the specificity towards various substrates. Various proteinaceous and non-proteinaceous inhibitors discussed could be helpful in controlling pest infestation. In depth detailed studies are required on proteinaceous α-AI-α-amylase interaction at different pH's as well as the insect proteinase action on these inhibitors before selecting the α-AI for making transgenics resistant to particular insect. Copyright © 2014 Elsevier Inc. All rights reserved.

Method for forming suspended micromechanical structures

DOEpatents

Fleming, James G.

2000-01-01

A micromachining method is disclosed for forming a suspended micromechanical structure from {111} crystalline silicon. The micromachining method is based on the use of anisotropic dry etching to define lateral features of the structure which are etched down into a {111}-silicon substrate to a first etch depth, thereby forming sidewalls of the structure. The sidewalls are then coated with a protection layer, and the substrate is dry etched to a second etch depth to define a spacing of the structure from the substrate. A selective anisotropic wet etchant (e.g. KOH, EDP, TMAH, NaOH or CsOH) is used to laterally undercut the structure between the first and second etch depths, thereby forming a substantially planar lower surface of the structure along a {111} crystal plane that is parallel to an upper surface of the structure. The lateral extent of undercutting by the wet etchant is controlled and effectively terminated by either timing the etching, by the location of angled {111}-silicon planes or by the locations of preformed etch-stops. This present method allows the formation of suspended micromechanical structures having large vertical dimensions and large masses while allowing for detailed lateral features which can be provided by dry etch definition. Additionally, the method of the present invention is compatible with the formation of electronic circuitry on the substrate.

CFD Analysis and Design of Detailed Target Configurations for an Accelerator-Driven Subcritical System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kraus, Adam; Merzari, Elia; Sofu, Tanju

2016-08-01

High-fidelity analysis has been utilized in the design of beam target options for an accelerator driven subcritical system. Designs featuring stacks of plates with square cross section have been investigated for both tungsten and uranium target materials. The presented work includes the first thermal-hydraulic simulations of the full, detailed target geometry. The innovative target cooling manifold design features many regions with complex flow features, including 90 bends and merging jets, which necessitate three-dimensional fluid simulations. These were performed using the commercial computational fluid dynamics code STAR-CCM+. Conjugate heat transfer was modeled between the plates, cladding, manifold structure, and fluid. Steady-statemore » simulations were performed but lacked good residual convergence. Unsteady simulations were then performed, which converged well and demonstrated that flow instability existed in the lower portion of the manifold. It was established that the flow instability had little effect on the peak plate temperatures, which were well below the melting point. The estimated plate surface temperatures and target region pressure were shown to provide sufficient margin to subcooled boiling for standard operating conditions. This demonstrated the safety of both potential target configurations during normal operation.« less

Macromolecular Crystallization in Microgravity

NASA Technical Reports Server (NTRS)

Snell, Edward H.; Helliwell, John R.

2004-01-01

The key concepts that attracted crystal growers, macromolecular or solid state, to microgravity research is that density difference fluid flows and sedimentation of the growing crystals are greatly reduced. Thus, defects and flaws in the crystals can be reduced, even eliminated, and crystal volume can be increased. Macromolecular crystallography differs from the field of crystalline semiconductors. For the latter, crystals are harnessed for their electrical behaviors. A crystal of a biological macromolecule is used instead for diffraction experiments (X-ray or neutron) to determine the three-dimensional structure of the macromolecule. The better the internal order of the crystal of a biological macromolecule then the more molecular structure detail that can be extracted. This structural information that enables an understanding of how the molecule functions. This knowledge is changing the biological and chemical sciences with major potential in understanding disease pathologies. Macromolecular structural crystallography in general is a remarkable field where physics, biology, chemistry, and mathematics meet to enable insight to the basic fundamentals of life. In this review, we examine the use of microgravity as an environment to grow macromolecular crystals. We describe the crystallization procedures used on the ground, how the resulting crystals are studied and the knowledge obtained from those crystals. We address the features desired in an ordered crystal and the techniques used to evaluate those features in detail. We then introduce the microgravity environment, the techniques to access that environment, and the theory and evidence behind the use of microgravity for crystallization experiments. We describe how ground-based laboratory techniques have been adapted to microgravity flights and look at some of the methods used to analyze the resulting data. Several case studies illustrate the physical crystal quality improvements and the macromolecular structural advances. Finally, limitations and alternatives to microgravity and future directions for this research are covered.

A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations

PubMed Central

Alberini, Giulio; Benfenati, Fabio

2017-01-01

Tight-junctions between epithelial cells of biological barriers are specialized molecular structures that regulate the flux of solutes across the barrier, parallel to cell walls. The tight-junction backbone is made of strands of transmembrane proteins from the claudin family, but the molecular mechanism of its function is still not completely understood. Recently, the crystal structure of a mammalian claudin-15 was reported, displaying for the first time the detailed features of transmembrane and extracellular domains. Successively, a structural model of claudin-15-based paracellular channels has been proposed, suggesting a putative assembly that illustrates how claudins associate in the same cell (via cis interactions) and across adjacent cells (via trans interactions). Although very promising, the model offers only a static conformation, with residues missing in the most important extracellular regions and potential steric clashes. Here we present detailed atomic models of paracellular single and double pore architectures, obtained from the putative assembly and refined via structural modeling and all-atom molecular dynamics simulations in double membrane bilayer and water environment. Our results show an overall stable configuration of the complex with a fluctuating pore size. Extracellular residue loops in trans interaction are able to form stable contacts and regulate the size of the pore, which displays a stationary radius of 2.5–3.0 Å at the narrowest region. The side-by-side interactions of the cis configuration are preserved via stable hydrogen bonds, already predicted by cysteine crosslinking experiments. Overall, this work introduces an improved version of the claudin-15-based paracellular channel model that strengthens its validity and that can be used in further computational studies to understand the structural features of tight-junctions regulation. PMID:28863193

New Observations at the Slate Islands Impact Structure, Lake Superior

NASA Technical Reports Server (NTRS)

Dressler, B. O.; Sharpton, V. L.; Schnieders, B.; Scott, J.

1995-01-01

Slate Islands, a group of 2 large and several small islands, is located in northern Lake Superior, approximately 10 km south of Terrace Bay. Shatter cones, breccias and shock metamorphic features provide evidence that the Slate Islands Structure was formed as a result of asteroid or comet impact. Most of the island group is believed to represent the central uplift of a complex impact crater. The structure possibly has a diameter of about 32 km. For Sage (1978, 1991) shock metamorphic features, shatter cones and pervasive rock brecciation are the results of diatreme activity. The present investigations represent the second year of a co-operative study of the Lunar and Planetary Institute, Houston, Texas and the Field Services Section (Northwest) of the Ontario Geological Survey. The objective of this investigation is to come to a better understanding of the formation of mid-size impact structures on Earth and the planets of the solar system. Impact processes played a fundamental role in the formation of the planets and the evolution of life on Earth. Meteorite and comet impacts are not a phenomenon of the past. Last year, more than 20 pieces of the Shoemaker-Levy 9 impacted on Jupiter and the Tunguska comet impacted in Siberia in the early years of this century. The study of impact processes is a relatively young part of geoscience and much is still to be learnt by detailed field and laboratory investigations. The State Islands Structure has been selected for the present detailed investigations because of the excellent shoreline outcrops of rock units related to the impact. The structure is a complex impact crater that has been eroded so that important lithological and structural elements are exposed. We know of no other mid-size terrestrial impact structure with equal or better exposures. In this publication we present preliminary results of our 1994 and 1995 field and laboratory investigations. We have tentatively identified a few impact melt and a considerable number of suevite occurrences.

Principal component analysis for surface reflection components and structure in facial images and synthesis of facial images for various ages

NASA Astrophysics Data System (ADS)

Hirose, Misa; Toyota, Saori; Ojima, Nobutoshi; Ogawa-Ochiai, Keiko; Tsumura, Norimichi

2017-08-01

In this paper, principal component analysis is applied to the distribution of pigmentation, surface reflectance, and landmarks in whole facial images to obtain feature values. The relationship between the obtained feature vectors and the age of the face is then estimated by multiple regression analysis so that facial images can be modulated for woman aged 10-70. In a previous study, we analyzed only the distribution of pigmentation, and the reproduced images appeared to be younger than the apparent age of the initial images. We believe that this happened because we did not modulate the facial structures and detailed surfaces, such as wrinkles. By considering landmarks and surface reflectance over the entire face, we were able to analyze the variation in the distributions of facial structures and fine asperity, and pigmentation. As a result, our method is able to appropriately modulate the appearance of a face so that it appears to be the correct age.

The Power of Materials Science Tools for Gaining Insights into Organic Semiconductors

NASA Astrophysics Data System (ADS)

Treat, Neil D.; Westacott, Paul; Stingelin, Natalie

2015-07-01

The structure of organic semiconductors can be complex because features from the molecular level (such as molecular conformation) to the micrometer scale (such as the volume fraction and composition of phases, phase distribution, and domain size) contribute to the definition of the optoelectronic landscape of the final architectures and, hence, to device performance. As a consequence, a detailed understanding of how to manipulate molecular ordering, e.g., through knowledge of relevant phase transitions, of the solidification process, of relevant solidification mechanisms, and of kinetic factors, is required to induce the desired optoelectronic response. In this review, we discuss relevant structural features of single-component and multicomponent systems; provide a case study of the multifaceted structure that polymer:fullerene systems can adopt; and highlight relevant solidification mechanisms such as nucleation and growth, liquid-liquid phase separation, and spinodal decomposition. In addition, cocrystal formation, solid solutions, and eutectic systems are treated and their relevance within the optoelectronic area emphasized.

Anatomy of Old Faithful From Subsurface Seismic Imaging of the Yellowstone Upper Geyser Basin

NASA Astrophysics Data System (ADS)

Wu, Sin-Mei; Ward, Kevin M.; Farrell, Jamie; Lin, Fan-Chi; Karplus, Marianne; Smith, Robert B.

2017-10-01

The Upper Geyser Basin in Yellowstone National Park contains one of the highest concentrations of hydrothermal features on Earth including the iconic Old Faithful geyser. Although this system has been the focus of many geological, geochemical, and geophysical studies for decades, the shallow (<200 m) subsurface structure remains poorly characterized. To investigate the detailed subsurface geologic structure including the hydrothermal plumbing of the Upper Geyser Basin, we deployed an array of densely spaced three-component nodal seismographs in November of 2015. In this study, we extract Rayleigh wave seismic signals between 1 and 10 Hz utilizing nondiffusive seismic waves excited by nearby active hydrothermal features with the following results: (1) imaging the shallow subsurface structure by utilizing stationary hydrothermal activity as a seismic source, (2) characterizing how local geologic conditions control the formation and location of the Old Faithful hydrothermal system, and (3) resolving a relatively shallow (10-60 m) and large reservoir located 100 m southwest of Old Faithful geyser.

Assessment of groundwater potentiality using geophysical techniques in Wadi Allaqi basin, Eastern Desert, Egypt - Case study

NASA Astrophysics Data System (ADS)

Helaly, Ahmad Sobhy

2017-12-01

Electrical resistivity surveying has been carried out for the determination of the thickness and resistivity of layered media in Wadi Allaqi, Eastern Desert, Egypt. That is widely used geophysical tool for the purpose of assessing the groundwater potential and siting the best locations for boreholes in the unconfined Nubian Sandstone aquifers within the study area. This has been done using thirteen 1D Vertical Electrical Sounding (VES) surveys. 1D-VES surveys provide only layered model structures for the subsurface and do not provide comprehensive information for interpreting the structure and extent of subsurface hydro-geological features. The integration of two-dimensional (2D) geophysical techniques for groundwater prospecting has been done to provide a more detailed identification for the subsurface hydro-geological features from which potential sites for successful borehole locations are recognized. In addition, five magnetic profiles were measured for basement depth determination, expected geological structures and thickness of sedimentary succession that could include some basins suitable for groundwater accumulation as groundwater aquifers.

Mergers of Non-spinning Black-hole Binaries: Gravitational Radiation Characteristics

NASA Technical Reports Server (NTRS)

Baker, John G.; Boggs, William D.; Centrella, Joan; Kelly, Bernard J.; McWilliams, Sean T.; vanMeter, James R.

2008-01-01

We present a detailed descriptive analysis of the gravitational radiation from black-hole binary mergers of non-spinning black holes, based on numerical simulations of systems varying from equal-mass to a 6:1 mass ratio. Our primary goal is to present relatively complete information about the waveforms, including all the leading multipolar components, to interested researchers. In our analysis, we pursue the simplest physical description of the dominant features in the radiation, providing an interpretation of the waveforms in terms of an implicit rotating source. This interpretation applies uniformly to the full wavetrain, from inspiral through ringdown. We emphasize strong relationships among the l = m modes that persist through the full wavetrain. Exploring the structure of the waveforms in more detail, we conduct detailed analytic fitting of the late-time frequency evolution, identifying a key quantitative feature shared by the l = m modes among all mass-ratios. We identify relationships, with a simple interpretation in terms of the implicit rotating source, among the evolution of frequency and amplitude, which hold for the late-time radiation. These detailed relationships provide sufficient information about the late-time radiation to yield a predictive model for the late-time waveforms, an alternative to the common practice of modeling by a sum of quasinormal mode overtones. We demonstrate an application of this in a new effective-one-body-based analytic waveform model.

EIA model documentation: World oil refining logistics demand model,``WORLD`` reference manual. Version 1.1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-04-11

This manual is intended primarily for use as a reference by analysts applying the WORLD model to regional studies. It also provides overview information on WORLD features of potential interest to managers and analysts. Broadly, the manual covers WORLD model features in progressively increasing detail. Section 2 provides an overview of the WORLD model, how it has evolved, what its design goals are, what it produces, and where it can be taken with further enhancements. Section 3 reviews model management covering data sources, managing over-optimization, calibration and seasonality, check-points for case construction and common errors. Section 4 describes in detailmore » the WORLD system, including: data and program systems in overview; details of mainframe and PC program control and files;model generation, size management, debugging and error analysis; use with different optimizers; and reporting and results analysis. Section 5 provides a detailed description of every WORLD model data table, covering model controls, case and technology data. Section 6 goes into the details of WORLD matrix structure. It provides an overview, describes how regional definitions are controlled and defines the naming conventions for-all model rows, columns, right-hand sides, and bounds. It also includes a discussion of the formulation of product blending and specifications in WORLD. Several Appendices supplement the main sections.« less

Mergers of nonspinning black-hole binaries: Gravitational radiation characteristics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, John G.; Centrella, Joan; Kelly, Bernard J.

2008-08-15

We present a detailed descriptive analysis of the gravitational radiation from black-hole binary mergers of nonspinning black holes, based on numerical simulations of systems varying from equal mass to a 6 ratio 1 mass ratio. Our primary goal is to present relatively complete information about the waveforms, including all the leading multipolar components, to interested researchers. In our analysis, we pursue the simplest physical description of the dominant features in the radiation, providing an interpretation of the waveforms in terms of an implicit rotating source. This interpretation applies uniformly to the full wave train, from inspiral through ringdown. We emphasizemore » strong relationships among the l=m modes that persist through the full wave train. Exploring the structure of the waveforms in more detail, we conduct detailed analytic fitting of the late-time frequency evolution, identifying a key quantitative feature shared by the l=m modes among all mass ratios. We identify relationships, with a simple interpretation in terms of the implicit rotating source, among the evolution of frequency and amplitude, which hold for the late-time radiation. These detailed relationships provide sufficient information about the late-time radiation to yield a predictive model for the late-time waveforms, an alternative to the common practice of modeling by a sum of quasinormal mode overtones. We demonstrate an application of this in a new effective-one-body-based analytic waveform model.« less

Neptune's Southern Hemisphere

NASA Technical Reports Server (NTRS)

1989-01-01

This photograph of Neptune's southern hemisphere was taken by the narrow-angle camera on NASA's Voyager 2 when the spacecraft was 4.2 million km (2.6 million miles) from the planet. The smallest features that can be seen are 38 km (24 miles) across. The almond-shaped structure at the left is a large cloud system that has been seen for several weeks. Internal details in the feature have become increasingly apparent as Voyager 2 has approached. Systems with similar shapes in Jupiter's atmosphere rotate about their centers, rolling in the local winds that increase toward the south. However, the wispy nature of the white central clouds in this Neptunian feature make confirmation of the system's rotation difficult. The Voyager Mission is conducted by JPL for NASA's Office of Space Science and Applications.

New Voyager radio spectrograms of Uranus

NASA Technical Reports Server (NTRS)

Calvert, W.; Tsintikidis, D.

1990-01-01

New, high-resolution spectrograms of the Voyager-2 radio observations at Uranus were produced from the original, six-second Planetary Radio Astronomy (PRA) data and these show a number of new features which were not obvious in previous versions. Among these new features are the detailed structure of the so-called broadband-bursty (b-bursty) emissions, unexpected sloping striations in the smooth high-frequency (SHF) component, and the overlap of these two components during the first rotation after closest approach. In addition, a slightly different planetary rotation rate from the b-bursty emissions, was found, and at the initial onset of the SHF component, what appears to be the shadow of a Uranian plasmasphere. These new spectrograms were prepared using a special dithering algorithm to show signal strengths as gray shadings, and the data were also manually cleaned to suppress noise and interference. This produced spectrograms of exceptional quality and certain details of their production on a stand-alone personal computer are also discussed.

Strain-induced macroscopic magnetic anisotropy from smectic liquid-crystalline elastomer-maghemite nanoparticle hybrid nanocomposites.

PubMed

Haberl, Johannes M; Sánchez-Ferrer, Antoni; Mihut, Adriana M; Dietsch, Hervé; Hirt, Ann M; Mezzenga, Raffaele

2013-06-21

We combine tensile strength analysis and X-ray scattering experiments to establish a detailed understanding of the microstructural coupling between liquid-crystalline elastomer (LCE) networks and embedded magnetic core-shell ellipsoidal nanoparticles (NPs). We study the structural and magnetic re-organization at different deformations and NP loadings, and the associated shape and magnetic memory features. In the quantitative analysis of a stretching process, the effect of the incorporated NPs on the smectic LCE is found to be prominent during the reorientation of the smectic domains and the softening of the nanocomposite. Under deformation, the soft response of the nanocomposite material allows the organization of the nanoparticles to yield a permanent macroscopically anisotropic magnetic material. Independent of the particle loading, the shape-memory properties and the smectic phase of the LCEs are preserved. Detailed studies on the magnetic properties demonstrate that the collective ensemble of individual particles is responsible for the macroscopic magnetic features of the nanocomposite.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grillot, L.R.; Anderton, P.W.; Haselton, T.M.

The Espoir oil field, located approximately 13 km offshore Ivory Coast, was discovered in 1980 by a joint venture comprised of Phillips Petroleum Company, AGIP, SEDCO Energy, and PETROCI. Following the discovery, a three-dimensional seismic survey was recorded by GSI in 1981-1982 to provide detailed seismic coverage of Espoir field and adjacent features. The seismic program consisted of 7700 line-km of data acquired in a single survey area that is located on the edge of the continental shelf and extends into deep water. In comparison with previous two-dimensional seismic surveys, the three-dimensional data provided several improvements in interpretation and mappingmore » including: (1) sharper definition of structural features, (2) reliable correlations of horizons and fault traces between closely spaced tracks, (3) detailed time contour maps from time-slice sections, and (4) improved velocity model for depth conversion. The improved mapping helped us identify additional well locations; the results of these wells compared favorably with the interpretation made prior to drilling.« less

Middle Eastern rhinoplasty.

PubMed

Azizzadeh, Babak; Mashkevich, Grigoriy

2010-02-01

The ethnic appearance of the Middle Eastern nose is defined by several unique visual features, particularly a high radix, wide overprojecting dorsum, and an amorphous hanging nasal tip. These external characteristics reflect distinct structural properties of the osseo-cartilaginous nasal framework and skin-soft tissue envelope in patients of Middle Eastern extraction. The goal, and the ultimate challenge, of rhinoplasty on Middle Eastern patients is to achieve balanced aesthetic refinement, while avoiding surgical westernization. Detailed understanding of the ethnic visual harmony in a Middle Eastern nose greatly assists in preserving native nasal-facial relationships during rhinoplasty on Middle Eastern patients. Esthetic alteration of a Middle Eastern nose follows a different set of goals and principles compared with rhinoplasties on white or other ethnic patients. This article highlights the inherent nasal features of the Middle Eastern nose and reviews pertinent concepts of rhinoplasty on Middle Eastern patients. Essential considerations in the process spanning the consultation and surgery are reviewed. Reliable operative techniques that achieve a successful aesthetic outcome are discussed in detail. Copyright 2010 Elsevier Inc. All rights reserved.

An Investigation of Chaotic Kolmogorov Flows

DTIC Science & Technology

1990-08-01

plane for the Poincare sections used later. The choice of the constant D controls apparent positioning of the hyperplane in the phase...discovered in large scale structure regime. Features of the diverse cases are displayed in terms of the temporal power spectrum, Poincare sections and...examine in some detail the behavior of the flow and its transition states for a range of the bifurcation parameter Re. We use Poincare sections to

Design of the advanced regional aircraft, the DART-75

NASA Technical Reports Server (NTRS)

Elliott, Steve; Gislason, Jason; Huffstetler, Mark; Mann, Jon; Withers, Ashley; Zimmerman, Mark

1992-01-01

This design analysis is intended to show the capabilities of the DART-75, a 75 passenger medium-range regional transport. Included are the detailed descriptions of the structures, performance, stability and control, weight and balance, and engine design. The design should allow for the DART to become the premier regional aircraft of the future due to some advanced features like the canard, semi-composite construction, and advanced engines.

Three-Way Analysis of Spectrospatial Electromyography Data: Classification and Interpretation

PubMed Central

Kauppi, Jukka-Pekka; Hahne, Janne; Müller, Klaus-Robert; Hyvärinen, Aapo

2015-01-01

Classifying multivariate electromyography (EMG) data is an important problem in prosthesis control as well as in neurophysiological studies and diagnosis. With modern high-density EMG sensor technology, it is possible to capture the rich spectrospatial structure of the myoelectric activity. We hypothesize that multi-way machine learning methods can efficiently utilize this structure in classification as well as reveal interesting patterns in it. To this end, we investigate the suitability of existing three-way classification methods to EMG-based hand movement classification in spectrospatial domain, as well as extend these methods by sparsification and regularization. We propose to use Fourier-domain independent component analysis as preprocessing to improve classification and interpretability of the results. In high-density EMG experiments on hand movements across 10 subjects, three-way classification yielded higher average performance compared with state-of-the art classification based on temporal features, suggesting that the three-way analysis approach can efficiently utilize detailed spectrospatial information of high-density EMG. Phase and amplitude patterns of features selected by the classifier in finger-movement data were found to be consistent with known physiology. Thus, our approach can accurately resolve hand and finger movements on the basis of detailed spectrospatial information, and at the same time allows for physiological interpretation of the results. PMID:26039100

The Boeing 747 fatigue integrity program

NASA Technical Reports Server (NTRS)

Spencer, M. M.

1972-01-01

The fatigue integrity program which was established to insure economic operations and to provide foundation data for inspection and maintenance is discussed. Significant features of the 747 fatigue integrity program are: (1) fatigue analyses which are continually updated to reflect design changes, fatigue test results, and static and flight load survey measurements; (2) material selection and detail design by using initial fatigue analyses, service experience, and testing; and (3) fatigue testing to check detail design quality and to verify the analyses, culminated by the test of a structurally complete airframe. Fatigue stress analyses were performed with the aid of experimental as well as analytical procedures. Extensive application was made of the stress severity factor, developed at Boeing, for evaluating peak stresses in complex joints. A frame of reference was established by families of structural fatigue performance curves (S-N curves) encompassing the range of materials and fatigue qualities anticipated for the 747 airplane design.

Volume illustration of muscle from diffusion tensor images.

PubMed

Chen, Wei; Yan, Zhicheng; Zhang, Song; Crow, John Allen; Ebert, David S; McLaughlin, Ronald M; Mullins, Katie B; Cooper, Robert; Ding, Zi'ang; Liao, Jun

2009-01-01

Medical illustration has demonstrated its effectiveness to depict salient anatomical features while hiding the irrelevant details. Current solutions are ineffective for visualizing fibrous structures such as muscle, because typical datasets (CT or MRI) do not contain directional details. In this paper, we introduce a new muscle illustration approach that leverages diffusion tensor imaging (DTI) data and example-based texture synthesis techniques. Beginning with a volumetric diffusion tensor image, we reformulate it into a scalar field and an auxiliary guidance vector field to represent the structure and orientation of a muscle bundle. A muscle mask derived from the input diffusion tensor image is used to classify the muscle structure. The guidance vector field is further refined to remove noise and clarify structure. To simulate the internal appearance of the muscle, we propose a new two-dimensional example based solid texture synthesis algorithm that builds a solid texture constrained by the guidance vector field. Illustrating the constructed scalar field and solid texture efficiently highlights the global appearance of the muscle as well as the local shape and structure of the muscle fibers in an illustrative fashion. We have applied the proposed approach to five example datasets (four pig hearts and a pig leg), demonstrating plausible illustration and expressiveness.

Automatic detection of multi-level acetowhite regions in RGB color images of the uterine cervix

NASA Astrophysics Data System (ADS)

Lange, Holger

2005-04-01

Uterine cervical cancer is the second most common cancer among women worldwide. Colposcopy is a diagnostic method used to detect cancer precursors and cancer of the uterine cervix, whereby a physician (colposcopist) visually inspects the metaplastic epithelium on the cervix for certain distinctly abnormal morphologic features. A contrast agent, a 3-5% acetic acid solution, is used, causing abnormal and metaplastic epithelia to turn white. The colposcopist considers diagnostic features such as the acetowhite, blood vessel structure, and lesion margin to derive a clinical diagnosis. STI Medical Systems is developing a Computer-Aided-Diagnosis (CAD) system for colposcopy -- ColpoCAD, a complex image analysis system that at its core assesses the same visual features as used by colposcopists. The acetowhite feature has been identified as one of the most important individual predictors of lesion severity. Here, we present the details and preliminary results of a multi-level acetowhite region detection algorithm for RGB color images of the cervix, including the detection of the anatomic features: cervix, os and columnar region, which are used for the acetowhite region detection. The RGB images are assumed to be glare free, either obtained by cross-polarized image acquisition or glare removal pre-processing. The basic approach of the algorithm is to extract a feature image from the RGB image that provides a good acetowhite to cervix background ratio, to segment the feature image using novel pixel grouping and multi-stage region-growing algorithms that provide region segmentations with different levels of detail, to extract the acetowhite regions from the region segmentations using a novel region selection algorithm, and then finally to extract the multi-levels from the acetowhite regions using multiple thresholds. The performance of the algorithm is demonstrated using human subject data.

Computer ranking of the sequence of appearance of 100 features of the brain and related structures in staged human embryos during the first 5 weeks of development.

PubMed

O'Rahilly, R; Müller, F; Hutchins, G M; Moore, G W

1984-11-01

The sequence of events in the development of the brain in staged human embryos was investigated in much greater detail than in previous studies by listing 100 features in 165 embryos of the first 5 weeks. Using a computerized bubble-sort algorithm, individual embryos were ranked in ascending order of the features present. This procedure made feasible an appreciation of the slight variation found in the developmental features. The vast majority of features appeared during either one or two stages (about 2 or 3 days). In general, the soundness of the Carnegie system of embryonic staging was amply confirmed. The rhombencephalon was found to show increasing complexity around stage 13, and the postoptic portion of the diencephalon underwent considerable differentiation by stage 15. The need for similar investigations of other systems of the body is emphasized, and the importance of such studies in assessing the timing of congenital malformations and in clarifying syndromic clusters is suggested.

Insights from Molecular Dynamics Simulations: Structural Basis for the V567D Mutation-Induced Instability of Zebrafish Alpha-Dystroglycan and Comparison with the Murine Model

PubMed Central

Pirolli, Davide; Sciandra, Francesca; Bozzi, Manuela; Giardina, Bruno; Brancaccio, Andrea; De Rosa, Maria Cristina

2014-01-01

A missense amino acid mutation of valine to aspartic acid in 567 position of alpha-dystroglycan (DG), identified in dag1-mutated zebrafish, results in a reduced transcription and a complete absence of the protein. Lacking experimental structural data for zebrafish DG domains, the detailed mechanism for the observed mutation-induced destabilization of the DG complex and membrane damage, remained unclear. With the aim to contribute to a better clarification of the structure-function relationships featuring the DG complex, three-dimensional structural models of wild-type and mutant (V567D) C-terminal domain of alpha-DG from zebrafish were constructed by a template-based modelling approach. We then ran extensive molecular dynamics (MD) simulations to reveal the structural and dynamic properties of the C-terminal domain and to evaluate the effect of the single mutation on alpha-DG stability. A comparative study has been also carried out on our previously generated model of murine alpha-DG C-terminal domain including the I591D mutation, which is topologically equivalent to the V567D mutation found in zebrafish. Trajectories from MD simulations were analyzed in detail, revealing extensive structural disorder involving multiple beta-strands in the mutated variant of the zebrafish protein whereas local effects have been detected in the murine protein. A biochemical analysis of the murine alpha-DG mutant I591D confirmed a pronounced instability of the protein. Taken together, the computational and biochemical analysis suggest that the V567D/I591D mutation, belonging to the G beta-strand, plays a key role in inducing a destabilization of the alpha-DG C-terminal Ig-like domain that could possibly affect and propagate to the entire DG complex. The structural features herein identified may be of crucial help to understand the molecular basis of primary dystroglycanopathies. PMID:25078606

Insights from molecular dynamics simulations: structural basis for the V567D mutation-induced instability of zebrafish alpha-dystroglycan and comparison with the murine model.

PubMed

Pirolli, Davide; Sciandra, Francesca; Bozzi, Manuela; Giardina, Bruno; Brancaccio, Andrea; De Rosa, Maria Cristina

2014-01-01

A missense amino acid mutation of valine to aspartic acid in 567 position of alpha-dystroglycan (DG), identified in dag1-mutated zebrafish, results in a reduced transcription and a complete absence of the protein. Lacking experimental structural data for zebrafish DG domains, the detailed mechanism for the observed mutation-induced destabilization of the DG complex and membrane damage, remained unclear. With the aim to contribute to a better clarification of the structure-function relationships featuring the DG complex, three-dimensional structural models of wild-type and mutant (V567D) C-terminal domain of alpha-DG from zebrafish were constructed by a template-based modelling approach. We then ran extensive molecular dynamics (MD) simulations to reveal the structural and dynamic properties of the C-terminal domain and to evaluate the effect of the single mutation on alpha-DG stability. A comparative study has been also carried out on our previously generated model of murine alpha-DG C-terminal domain including the I591D mutation, which is topologically equivalent to the V567D mutation found in zebrafish. Trajectories from MD simulations were analyzed in detail, revealing extensive structural disorder involving multiple beta-strands in the mutated variant of the zebrafish protein whereas local effects have been detected in the murine protein. A biochemical analysis of the murine alpha-DG mutant I591D confirmed a pronounced instability of the protein. Taken together, the computational and biochemical analysis suggest that the V567D/I591D mutation, belonging to the G beta-strand, plays a key role in inducing a destabilization of the alpha-DG C-terminal Ig-like domain that could possibly affect and propagate to the entire DG complex. The structural features herein identified may be of crucial help to understand the molecular basis of primary dystroglycanopathies.

FT IR spectral investigations of toxic material dibrom using DFT

NASA Astrophysics Data System (ADS)

Parvathy, M.; Gopika, M. S.; Mary, B. L. Bincy; Nimmi, D. E.; Praveen, S. G.; Binoy, J.

2018-05-01

Since, dibrom is widely used organophosphate pesticide, the exploration of its structural features is of immense research interest, and can be effectively carried out using infrared spectroscopy aided by DFT simulation. The present work aims to investigate the interrelation between carbon-halogen bond strength and electronegativity halogen. The resonance of phosphate in dibrom and the deviation from resonant structure due to bridging of oxygen by electron donating methyl group has been investigated in detail. The molecular docking study has been performed to explore the bioactivity of dibrom and to assess the strength of interaction of dibrom towards DNA and BSA.

Analysis of Yb3+/Er3+-codoped microring resonator cross-grid matrices

NASA Astrophysics Data System (ADS)

Vallés, Juan A.; Gǎlǎtuş, Ramona

2014-09-01

An analytic model of the scattering response of a highly Yb3+/Er3+-codoped phosphate glass microring resonator matrix is considered to obtain the transfer functions of an M x N cross-grid microring resonator structure. Then a detailed model is used to calculate the pump and signal propagation, including a microscopic statistical formalism to describe the high-concentration induced energy-transfer mechanisms and passive and active features are combined to realistically simulate the performance as a wavelength-selective amplifier or laser. This analysis allows the optimization of these structures for telecom or sensing applications.

Standardization of accelerator irradiation procedures for simulation of neutron induced damage in reactor structural materials

NASA Astrophysics Data System (ADS)

Shao, Lin; Gigax, Jonathan; Chen, Di; Kim, Hyosim; Garner, Frank A.; Wang, Jing; Toloczko, Mychailo B.

2017-10-01

Self-ion irradiation is widely used as a method to simulate neutron damage in reactor structural materials. Accelerator-based simulation of void swelling, however, introduces a number of neutron-atypical features which require careful data extraction and, in some cases, introduction of innovative irradiation techniques to alleviate these issues. We briefly summarize three such atypical features: defect imbalance effects, pulsed beam effects, and carbon contamination. The latter issue has just been recently recognized as being relevant to simulation of void swelling and is discussed here in greater detail. It is shown that carbon ions are entrained in the ion beam by Coulomb force drag and accelerated toward the target surface. Beam-contaminant interactions are modeled using molecular dynamics simulation. By applying a multiple beam deflection technique, carbon and other contaminants can be effectively filtered out, as demonstrated in an irradiation of HT-9 alloy by 3.5 MeV Fe ions.

Astragalar Morphology of Selected Giraffidae.

PubMed

Solounias, Nikos; Danowitz, Melinda

2016-01-01

The artiodactyl astragalus has been modified to exhibit two trochleae, creating a double pullied structure allowing for significant dorso-plantar motion, and limited mediolateral motion. The astragalus structure is partly influenced by environmental substrates, and correspondingly, morphometric studies can yield paleohabitat information. The present study establishes terminology and describes detailed morphological features on giraffid astragali. Each giraffid astragalus exhibits a unique combination of anatomical characteristics. The giraffid astragalar morphologies reinforce previously established phylogenetic relationships. We find that the enlargement of the navicular head is a feature shared by all giraffids, and that the primitive giraffids possess exceptionally tall astragalar heads in relation to the total astragalar height. The sivatheres and the okapi share a reduced notch on the lateral edge of the astragalus. We find that Samotherium is more primitive in astragalar morphologies than Palaeotragus, which is reinforced by tooth characteristics and ossicone position. Diagnostic anatomical characters on the astragalus allow for giraffid species identifications and a better understanding of Giraffidae.

Streaks, multiplets, and holes: High-resolution spatio-temporal behavior of Parkfield seismicity

USGS Publications Warehouse

Waldhauser, F.; Ellsworth, W.L.; Schaff, D.P.; Cole, A.

2004-01-01

Double-difference locations of ???8000 earthquakes from 1969-2002 on the Parkfield section of the San Andreas Fault reveal detailed fault structures and seismicity that is, although complex, highly organized in both space and time. Distinctive features of the seismicity include: 1) multiple recurrence of earthquakes of the same size at precisely the same location on the fault (multiplets), implying frictional or geometric controls on their location and size; 2) sub-horizontal alignments of hypocenters along the fault plane (streaks), suggestive of rheological transitions within the fault zone and/or stress concentrations between locked and creeping areas; 3) regions devoid of microearthquakes with typical dimensions of 1-5 km (holes), one of which contains the M6 1966 Parkfield earthquake hypocenter. These features represent long lived structures that persist through many cycles of individual event. Copyright 2004 by the American Geophysical Union.

An investigation of chaotic Kolmogorov flows

NASA Technical Reports Server (NTRS)

Platt, N.; Sirovich, L.; Fitzmaurice, N.

1990-01-01

A two dimensional flow governed by the incompressible Navier-Stokes equations with a steady spatially periodic forcing (known as the Kolmogorov flow) is numerically simulated. The behavior of the flow and its transition states as the Reynolds number (Re) varies is investigated in detail, as well as a number of the flow features. A sequence of bifurcations is shown to take place in the flow as Re varied. Two main regimes of the flow were observed: small and large scale structure regimes corresponding to different ranges of Re. Each of the regimes includes a number of quasiperiodic, chaotic, and relaminarization windows. In addition, each range contains a chaotic window with non-ergodic chaotic attractors. Spatially disordered, but temporally steady states were discovered in large scale structure regime. Features of the diverse cases are displayed in terms of the temporal power spectrum, Poincare sections and, where possible, Lyapunov exponents and Kaplan-Yorke dimension.

K2 ZnSn3 Se8 : A Non-Centrosymmetric Zinc Selenidostannate(IV) Featuring Interesting Covalently Bonded [ZnSn3 Se8 ]2- Layer and Exhibiting Intriguing Second Harmonic Generation Activity.

PubMed

Zhou, Molin; Jiang, Xingxing; Yang, Yi; Guo, Yangwu; Lin, Zheshuai; Yao, JJiyong; Wu, Yicheng

2017-06-19

Non-centrosymmetric zinc selenidostannate(IV) K 2 ZnSn 3 Se 8 was synthesized. It features interesting covalently bonded [ZnSn 3 Se 8 ] 2- layers with K + cations filling in the interlayer voids. The phonon spectrum was calculated to clarify its structural stability. Based on the X-ray diffraction data along with the Raman spectrum, the major bonding features of the title compound were identified. According to the UV/vis-NIR spectroscopy, K 2 ZnSn 3 Se 8 possesses a typical direct band gap of 2.10 eV, which is in good agreement with the band structure calculations. Moreover, our experimental measurements and detailed theoretical calculations reveal that K 2 ZnSn 3 Se 8 is a new phase-matchable nonlinear optical material with a powder second harmonic generation (SHG) signal about 0.6 times of that of AgGaS 2 . © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Recent crustal movements and seismicity in the western coastal region of peninsular India

NASA Astrophysics Data System (ADS)

Kailasam, L. N.

1983-09-01

Recent crustal movements, tectonics and seismicity of the western coastal region of peninsular India have been studied in detail in the very recent past. Prominent geomorphic features and large-scale manifestation of Holocene deformation and crustal movements have been noticed and studied over this coastal region from the Gulf of Cambay to the southernmost parts of Kerala, evidence for which is afforded in the form of Recent and sub-Recent raised beaches, sandbars, raised old terraces, pebble beds, etc. The sedimentary formations in this narrow coastal belt include Neogene and Quaternary sediments. The Bouguer gravity map of the western coastal tract shows some prominent gravity features extending into the offshore regions, suggestive of some significant tectonic and structural features. The seismic data in the offshore regions bring out some prominent roughly northwest-southeast as well as east-west faults and shears, in addition to prominent structural "highs" off the Bombay and Ratnagiri coast which have proved oil. The seismicity in this coastal tract as well as the faulted western margin of the western continental shelf in the Arabian Sea is generally of magnitude 3-6.

Bismuth-induced Raman modes in GaP 1– xBi x

DOE PAGES

Christian, Theresa M.; Fluegel, Brian; Beaton, Daniel A.; ...

2016-09-02

Here, dilute bismide semiconductor alloys are a promising material platform for optoelectronic devices due to drastic impacts of bismuth on the electronic structure of the alloy. At the same time, the details of bismuth incorporation in the lattice are not fully understood. In this work, we conduct Raman scattering spectroscopy on GaP 1- xBi x epilayers grown by molecular beam epitaxy (MBE) and identify several bismuth-related Raman features including gap vibration modes at 296, 303, and 314 cm -1. This study paves the way for more detailed analysis of the local symmetry at bismuth incorporation sites in the dilute bismidemore » alloy regime.« less

Prediction of Protein Modification Sites of Pyrrolidone Carboxylic Acid Using mRMR Feature Selection and Analysis

PubMed Central

Zheng, Lu-Lu; Niu, Shen; Hao, Pei; Feng, KaiYan; Cai, Yu-Dong; Li, Yixue

2011-01-01

Pyrrolidone carboxylic acid (PCA) is formed during a common post-translational modification (PTM) of extracellular and multi-pass membrane proteins. In this study, we developed a new predictor to predict the modification sites of PCA based on maximum relevance minimum redundancy (mRMR) and incremental feature selection (IFS). We incorporated 727 features that belonged to 7 kinds of protein properties to predict the modification sites, including sequence conservation, residual disorder, amino acid factor, secondary structure and solvent accessibility, gain/loss of amino acid during evolution, propensity of amino acid to be conserved at protein-protein interface and protein surface, and deviation of side chain carbon atom number. Among these 727 features, 244 features were selected by mRMR and IFS as the optimized features for the prediction, with which the prediction model achieved a maximum of MCC of 0.7812. Feature analysis showed that all feature types contributed to the modification process. Further site-specific feature analysis showed that the features derived from PCA's surrounding sites contributed more to the determination of PCA sites than other sites. The detailed feature analysis in this paper might provide important clues for understanding the mechanism of the PCA formation and guide relevant experimental validations. PMID:22174779

Meteorite Impact Structures as Outcrop-Scale Analogues for Mountain Building Events: Weaubleau and Decaturville, MO

NASA Astrophysics Data System (ADS)

Wu, S.; McKay, M.; Evans, K. R.

2017-12-01

Understanding the architecture of mountain belts is limited because studies are typically confined to surficial exposures with lesser amounts of subsurface data and active margins are prone to successive tectonism that obscures the rock record. In west-central Missouri, two Paleozoic meteorite impacts are exposed that contain a range of outcrop-scale structures. While the strain rate in a meteorite impact is an order of magnitude greater than that in orogeny-scale structures, the morphology and spatial relationships in these impact structures may provide insight into larger tectonic features. The entire crater could not be compared to an orogenic event because the amount of strain diffuses as distance increases from the impactor during an impacting event. The center of an impact crater could not be compared to an orogenic event because it has become too deformed. However, the crater rim and the immediate surrounding area could be used as a comparison because it has undergone the right amount of deformation to have recognizable structures. High-detail mapping and structural analyses of road cut exposures near Decaturville, MO reveals thrust fault sequences contain 1-2 m thick mixed carbonate and clastic sheets that include rollover anticlines, structural orphans, and lateral ramp features. Thrust faults dip away from the impact structure and represent gravitational collapse of the central uplift seconds after collision. Thrust sheet thickness, thrust fault spacing, ramp/flat morphology, and shortening of within these structures will be presented and assessed as an analogue for map-scale features in the Southern Appalachian fold and thrust belt. Because temperature controls rock mechanic properties, a thermal model based on thermochronology and thermobarometry for the section will also be presented and discussed in the context of orogenic thermomechanics.

A Corner-Point-Grid-Based Voxelization Method for Complex Geological Structure Model with Folds

NASA Astrophysics Data System (ADS)

Chen, Qiyu; Mariethoz, Gregoire; Liu, Gang

2017-04-01

3D voxelization is the foundation of geological property modeling, and is also an effective approach to realize the 3D visualization of the heterogeneous attributes in geological structures. The corner-point grid is a representative data model among all voxel models, and is a structured grid type that is widely applied at present. When carrying out subdivision for complex geological structure model with folds, we should fully consider its structural morphology and bedding features to make the generated voxels keep its original morphology. And on the basis of which, they can depict the detailed bedding features and the spatial heterogeneity of the internal attributes. In order to solve the shortage of the existing technologies, this work puts forward a corner-point-grid-based voxelization method for complex geological structure model with folds. We have realized the fast conversion from the 3D geological structure model to the fine voxel model according to the rule of isocline in Ramsay's fold classification. In addition, the voxel model conforms to the spatial features of folds, pinch-out and other complex geological structures, and the voxels of the laminas inside a fold accords with the result of geological sedimentation and tectonic movement. This will provide a carrier and model foundation for the subsequent attribute assignment as well as the quantitative analysis and evaluation based on the spatial voxels. Ultimately, we use examples and the contrastive analysis between the examples and the Ramsay's description of isoclines to discuss the effectiveness and advantages of the method proposed in this work when dealing with the voxelization of 3D geologic structural model with folds based on corner-point grids.

Mapping protein-RNA interactions by RCAP, RNA-cross-linking and peptide fingerprinting.

PubMed

Vaughan, Robert C; Kao, C Cheng

2015-01-01

RNA nanotechnology often feature protein RNA complexes. The interaction between proteins and large RNAs are difficult to study using traditional structure-based methods like NMR or X-ray crystallography. RCAP, an approach that uses reversible-cross-linking affinity purification method coupled with mass spectrometry, has been developed to map regions within proteins that contact RNA. This chapter details how RCAP is applied to map protein-RNA contacts within virions.

Reproducible nucleation sites for flux dendrites in MgB 2

NASA Astrophysics Data System (ADS)

Johansen, T. H.; Shantsev, D. V.; Olsen, Å. A. F.; Roussel, M.; Pan, A. V.; Dou, S. X.

2007-12-01

Magneto-optical imaging was used to study dendritic flux penetration in films of MgB 2. By repeating experiments under the same external conditions, reproducible features were seen in the pattern formation; dendrites tend to nucleate from fixed locations along the edge. However, their detailed structure deeper inside the film is never reproduced. The reproducibility in nucleation sites is explained as a result of edge roughness causing field hot spots.

High-Temperature Magnetism as a Probe for Structural and Compositional Uniformity in Ligand-Capped Magnetite Nanoparticles

PubMed Central

2015-01-01

To investigate magnetostructural relationships in colloidal magnetite (Fe3O4) nanoparticles (NPs) at high temperature (300–900 K), we measured the temperature dependence of magnetization (M) of oleate-capped magnetite NPs ca. 20 nm in size. Magnetometry revealed an unusual irreversible high-temperature dependence of M for these NPs, with dip and loop features observed during heating–cooling cycles. Detailed characterizations of as-synthesized and annealed Fe3O4 NPs as well as reference ligand-free Fe3O4 NPs indicate that both types of features in M(T) are related to thermal decomposition of the capping ligands. The ligand decomposition upon the initial heating induces a reduction of Fe3+ to Fe2+ and the associated dip in M, leading to more structurally and compositionally uniform magnetite NPs. Having lost the protective ligands, the NPs continually sinter during subsequent heating cycles, resulting in divergent M curves featuring loops. The increase in M with sintering proceeds not only through elimination of a magnetically dead layer on the particle surface, as a result of a decrease in specific surface area with increasing size, but also through an uncommonly invoked effect resulting from a significant change in Fe3+/Fe2+ ratio with heat treatment. The interpretation of irreversible features in M(T) indicates that reversible M(T) behavior, conversely, can be expected only for ligand-free, structurally and compositionally uniform magnetite NPs, suggesting a general applicability of high-temperature M(T) measurements as an analytical method for probing the structure and composition of magnetic nanomaterials. PMID:25506407

Application of PALSAR-2 remote sensing data for structural geology and topographic mapping in Kelantan river basin, Malaysia

NASA Astrophysics Data System (ADS)

Beiranvand Pour, Amin; Hashim, Mazlan

2016-06-01

Natural hazards of geological origin are one of major problem during heavy monsoons rainfall in Kelantan state, peninsular Malaysia. Several landslides occur in this region are obviously connected to geological and topographical features, every year. Satellite synthetic aperture radar (SAR) data are particularly applicable for detection of geological structural and topographical features in tropical conditions. In this study, Phased Array type L-band Synthetic Aperture Radar (PALSAR-2), remote sensing data were used to identify high potential risk and susceptible zones for landslide in the Kelantan river basin. Adaptive Local Sigma filter was selected and applied to accomplish speckle reduction and preserving both edges and features in PALSAR-2 fine mode observation images. Different polarization images were integrated to enhance geological structures. Additionally, directional filters were applied to the PALSAR-2 Local Sigma resultant image for edge enhancement and detailed identification of linear features. Several faults, drainage patterns and lithological contact layers were identified at regional scale. In order to assess the results, fieldwork and GPS survey were conducted in the landslide affected zones in the Kelantan river basin. Results demonstrate the most of the landslides were associated with N-S, NNW-SSE and NE-SW trending faults, angulate drainage pattern and metamorphic and Quaternary units. Consequently, geologic structural map were produced for Kelantan river basin using recent PALSAR-2 data, which could be broadly applicable for landslide hazard assessment and delineation of high potential risk and susceptible areas. Landslide mitigation programmes could be conducted in the landslide recurrence regions for reducing catastrophes leading to economic losses and death.

Structural architecture of prothrombin in solution revealed by single molecule spectroscopy

DOE PAGES

Pozzi, Nicola; Bystranowska, Dominika; Zuo, Xiaobing; ...

2016-07-19

The coagulation factor prothrombin has a complex spatial organization of its modular assembly that comprises the N-terminal Gla domain, kringle-1, kringle-2, and the C-terminal protease domain connected by three intervening linkers. Here we use single molecule Förster resonance energy transfer to access the conformational landscape of prothrombin in solution and uncover structural features of functional significance that extend recent x-ray crystallographic analysis. Prothrombin exists in equilibrium between two alternative conformations, open and closed. The closed conformation predominates (70%) and features an unanticipated intramolecular collapse of Tyr 93 in kringle-1 onto Trp 547 in the protease domain that obliterates access tomore » the active site and protects the zymogen from autoproteolytic conversion to thrombin. The open conformation (30%) is more susceptible to chymotrypsin digestion and autoactivation, and features a shape consistent with recent x-ray crystal structures. Small angle x-ray scattering measurements of prothrombin wild type stabilized 70% in the closed conformation and of the mutant Y93A stabilized 80% in the open conformation directly document two envelopes that differ 50 Å in length. These findings reveal important new details on the conformational plasticity of prothrombin in solution and the drastic structural difference between its alternative conformations. Prothrombin uses the intramolecular collapse of kringle-1 onto the active site in the closed form to prevent autoactivation. As a result, the open-closed equilibrium also defines a new structural framework for the mechanism of activation of prothrombin by prothrombinase.« less

A PLANETARY LENSING FEATURE IN CAUSTIC-CROSSING HIGH-MAGNIFICATION MICROLENSING EVENTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, Sun-Ju; Hwang, Kyu-Ha; Ryu, Yoon-Hyun

Current microlensing follow-up observations focus on high-magnification events because of the high efficiency of planet detection. However, central perturbations of high-magnification events caused by a planet can also be produced by a very close or a very wide binary companion, and the two kinds of central perturbations are not generally distinguished without time consuming detailed modeling (a planet-binary degeneracy). Hence, it is important to resolve the planet-binary degeneracy that occurs in high-magnification events. In this paper, we investigate caustic-crossing high-magnification events caused by a planet and a wide binary companion. From this investigation, we find that because of the differentmore » magnification excess patterns inside the central caustics induced by the planet and the binary companion, the light curves of the caustic-crossing planetary-lensing events exhibit a feature that is discriminated from those of the caustic-crossing binary-lensing events, and the feature can be used to immediately distinguish between the planetary and binary companions. The planetary-lensing feature appears in the interpeak region between the two peaks of the caustic-crossings. The structure of the interpeak region for the planetary-lensing events is smooth and convex or boxy, whereas the structure for the binary-lensing events is smooth and concave. We also investigate the effect of a finite background source star on the planetary-lensing feature in the caustic-crossing high-magnification events. From this, we find that the convex-shaped interpeak structure appears in a certain range that changes with the mass ratio of the planet to the planet-hosting star.« less

Integrated topology and shape optimization in structural design

NASA Technical Reports Server (NTRS)

Bremicker, M.; Chirehdast, M.; Kikuchi, N.; Papalambros, P. Y.

1990-01-01

Structural optimization procedures usually start from a given design topology and vary its proportions or boundary shapes to achieve optimality under various constraints. Two different categories of structural optimization are distinguished in the literature, namely sizing and shape optimization. A major restriction in both cases is that the design topology is considered fixed and given. Questions concerning the general layout of a design (such as whether a truss or a solid structure should be used) as well as more detailed topology features (e.g., the number and connectivities of bars in a truss or the number of holes in a solid) have to be resolved by design experience before formulating the structural optimization model. Design quality of an optimized structure still depends strongly on engineering intuition. This article presents a novel approach for initiating formal structural optimization at an earlier stage, where the design topology is rigorously generated in addition to selecting shape and size dimensions. A three-phase design process is discussed: an optimal initial topology is created by a homogenization method as a gray level image, which is then transformed to a realizable design using computer vision techniques; this design is then parameterized and treated in detail by sizing and shape optimization. A fully automated process is described for trusses. Optimization of two dimensional solid structures is also discussed. Several application-oriented examples illustrate the usefulness of the proposed methodology.

Automatic recognition of conceptualization zones in scientific articles and two life science applications.

PubMed

Liakata, Maria; Saha, Shyamasree; Dobnik, Simon; Batchelor, Colin; Rebholz-Schuhmann, Dietrich

2012-04-01

Scholarly biomedical publications report on the findings of a research investigation. Scientists use a well-established discourse structure to relate their work to the state of the art, express their own motivation and hypotheses and report on their methods, results and conclusions. In previous work, we have proposed ways to explicitly annotate the structure of scientific investigations in scholarly publications. Here we present the means to facilitate automatic access to the scientific discourse of articles by automating the recognition of 11 categories at the sentence level, which we call Core Scientific Concepts (CoreSCs). These include: Hypothesis, Motivation, Goal, Object, Background, Method, Experiment, Model, Observation, Result and Conclusion. CoreSCs provide the structure and context to all statements and relations within an article and their automatic recognition can greatly facilitate biomedical information extraction by characterizing the different types of facts, hypotheses and evidence available in a scientific publication. We have trained and compared machine learning classifiers (support vector machines and conditional random fields) on a corpus of 265 full articles in biochemistry and chemistry to automatically recognize CoreSCs. We have evaluated our automatic classifications against a manually annotated gold standard, and have achieved promising accuracies with 'Experiment', 'Background' and 'Model' being the categories with the highest F1-scores (76%, 62% and 53%, respectively). We have analysed the task of CoreSC annotation both from a sentence classification as well as sequence labelling perspective and we present a detailed feature evaluation. The most discriminative features are local sentence features such as unigrams, bigrams and grammatical dependencies while features encoding the document structure, such as section headings, also play an important role for some of the categories. We discuss the usefulness of automatically generated CoreSCs in two biomedical applications as well as work in progress. A web-based tool for the automatic annotation of articles with CoreSCs and corresponding documentation is available online at http://www.sapientaproject.com/software http://www.sapientaproject.com also contains detailed information pertaining to CoreSC annotation and links to annotation guidelines as well as a corpus of manually annotated articles, which served as our training data. liakata@ebi.ac.uk Supplementary data are available at Bioinformatics online.

Molecular clouds and galactic spiral structure

NASA Technical Reports Server (NTRS)

Dame, T. M.

1984-01-01

Galactic CO line emission at 115 GHz was surveyed in order to study the distribution of molecular clouds in the inner galaxy. Comparison of this survey with similar H1 data reveals a detailed correlation with the most intense 21 cm features. To each of the classical 21 cm H1 spiral arms of the inner galaxy there corresponds a CO molecular arm which is generally more clearly defined and of higher contrast. A simple model is devised for the galactic distribution of molecular clouds. The modeling results suggest that molecular clouds are essentially transient objects, existing for 15 to 40 million years after their formation in a spiral arm, and are largely confined to spiral features about 300 pc wide.

Analysis of nanopore arrangement and structural features of anodic alumina layers formed by two-step anodizing in oxalic acid using the dedicated executable software

NASA Astrophysics Data System (ADS)

Zaraska, Leszek; Stępniowski, Wojciech J.; Sulka, Grzegorz D.; Ciepiela, Eryk; Jaskuła, Marian

2014-02-01

Anodic porous alumina layers were fabricated by a two-step self-organized anodization in 0.3 M oxalic acid under various anodizing potentials ranging from 30 to 60 V at two different temperatures (10 and 17 ∘C). The effect of anodizing conditions on structural features and pore arrangement of AAO was investigated in detail by using the dedicated executable publication combined with ImageJ software. With increasing anodizing potential, a linear increase of the average pore diameter, interpore distance, wall thickness and barrier layer thickness, as well as a decrease of the pore density, were observed. In addition, the higher pore diameter and porosity values were obtained for samples anodized at the elevated temperature, independently of the anodizing potential. A degree of pore order was investigated on the basis of Delaunay triangulations (defect maps) and calculation of pair distribution or angle distribution functions (PDF or ADF), respectively. All methods confirmed that in order to obtain nanoporous alumina with the best, hexagonal pore arrangement, the potential of 40 V should be applied during anodization. It was confirmed that the dedicated executable publication can be used to a fast and complex analysis of nanopore arrangement and structural features of nanoporous oxide layers.

KELVIN-HELMHOLTZ INSTABILITIES AT THE SLOSHING COLD FRONTS IN THE VIRGO CLUSTER AS A MEASURE FOR THE EFFECTIVE INTRACLUSTER MEDIUM VISCOSITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roediger, E.; Kraft, R. P.; Forman, W. R.

2013-02-10

Sloshing cold fronts (CFs) arise from minor merger triggered gas sloshing. Their detailed structure depends on the properties of the intracluster medium (ICM): hydrodynamical simulations predict the CFs to be distorted by Kelvin-Helmholtz instabilities (KHIs), but aligned magnetic fields, viscosity, or thermal conduction can suppress the KHIs. Thus, observing the detailed structure of sloshing CFs can be used to constrain these ICM properties. Both smooth and distorted sloshing CFs have been observed, indicating that the KHI is suppressed in some clusters, but not in all. Consequently, we need to address at least some sloshing clusters individually before drawing general conclusionsmore » about the ICM properties. We present the first detailed attempt to constrain the ICM properties in a specific cluster from the structure of its sloshing CF. Proximity and brightness make the Virgo Cluster an ideal target. We combine observations and Virgo-specific hydrodynamical sloshing simulations. Here, we focus on a Spitzer-like temperature-dependent viscosity as a mechanism to suppress the KHI, but discuss the alternative mechanisms in detail. We identify the CF at 90 kpc north and northeast of the Virgo center as the best location in the cluster to observe a possible KHI suppression. For viscosities {approx}> 10% of the Spitzer value KHIs at this CF are suppressed. We describe in detail the observable signatures at low and high viscosities, i.e., in the presence or the absence of KHIs. We find indications for a low ICM viscosity in archival XMM-Newton data and demonstrate the detectability of the predicted features in deep Chandra observations.« less

A combined experimental and theoretical spectroscopic protocol for determination of the structure of heterogeneous catalysts: developing the information content of the resonance Raman spectra of M1 MoVOx † †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01771e Click here for additional data file.

PubMed Central

Kubas, Adam; Noak, Johannes

2017-01-01

Absorption and multiwavelength resonance Raman spectroscopy are widely used to investigate the electronic structure of transition metal centers in coordination compounds and extended solid systems. In combination with computational methodologies that have predictive accuracy, they define powerful protocols to study the spectroscopic response of catalytic materials. In this work, we study the absorption and resonance Raman spectra of the M1 MoVOx catalyst. The spectra were calculated by time-dependent density functional theory (TD-DFT) in conjunction with the independent mode displaced harmonic oscillator model (IMDHO), which allows for detailed bandshape predictions. For this purpose cluster models with up to 9 Mo and V metallic centers are considered to represent the bulk structure of MoVOx. Capping hydrogens were used to achieve valence saturation at the edges of the cluster models. The construction of model structures was based on a thorough bonding analysis which involved conventional DFT and local coupled cluster (DLPNO-CCSD(T)) methods. Furthermore the relationship of cluster topology to the computed spectral features is discussed in detail. It is shown that due to the local nature of the involved electronic transitions, band assignment protocols developed for molecular systems can be applied to describe the calculated spectral features of the cluster models as well. The present study serves as a reference for future applications of combined experimental and computational protocols in the field of solid-state heterogeneous catalysis. PMID:28989667

Loading effects beneath the Gotvand-e Olya Reservoir (south-west of Iran) deduced from ambient noise tomography

NASA Astrophysics Data System (ADS)

Ebrahimi, M.; Tatar, M.; Aoudia, A.; Guidarelli, M.

2018-01-01

In order to define the precise shallow velocity structure beneath the second largest dam reservoir in Iran and to understand the loading effects on the underlying crust, the shear wave velocity of the shallow structure beneath the Gotvand-e Olya (hereinafter referred to as Gotvand) reservoir is determined through the inversion of group velocities obtained from seismic ambient noise tomography, using continuous data from 10 stations of a local network, installed to monitor the induced seismicity in the region surrounding the Gotvand and Masjed Soleyman dams for potential hazard. We obtained Rayleigh waves from cross-correlation of waveforms recorded 10 months before and the same duration after impoundment of the Gotvand reservoir and calculated the group velocity from dispersion analysis in the period range 2-8 s. The group velocity dispersion curves are used to produce 2-D group velocity tomographic maps. The resulting tomographic maps at short periods are well correlated with subsurface geological features and delineate distinct low- and high-velocity zones separated mainly by geological boundaries. The 3-D shear wave velocity structure provides detailed information about the crustal features underneath the reservoir. The results are consistent with the lithology of the region, and attest that ambient noise tomography (ANT) can be used for detailed studies of the velocity structure and lithology at shallow depths using continuous data from a dense local seismic network. An increase of shear wave velocity is observed at the deep parts (4-6 km) underneath the reservoir after impoundment of the dam, which could be caused by the changes in rocks properties after impoundment. However, at shallow depths (2-4 km), a decrease of Vs velocity is observed that can be associated to the penetration of water after the impoundment.

Molecular structure of self-assembled chiral nanoribbons and nanotubules revealed in the hydrated state.

PubMed

Oda, Reiko; Artzner, Franck; Laguerre, Michel; Huc, Ivan

2008-11-05

A detailed molecular organization of racemic 16-2-16 tartrate self-assembled multi-bilayer ribbons in the hydrated state is proposed where 16-2-16 amphiphiles, tartrate ions, and water molecules are all accurately positioned by comparing experimental X-ray powder diffraction and diffraction patterns derived from modeling studies. X-ray diffuse scattering studies show that molecular organization is not fundamentally altered when comparing the flat ribbons of the racemate to chirally twisted or helical ribbons of the pure tartrate enantiomer. Essential features of the three-dimensional molecular organizations of these structures include interdigitation of alkyl chains within each bilayer and well-defined networks of ionic and hydrogen bonds between cations, anions, and water molecules between bilayers. The detailed study of diffraction patterns also indicated that the gemini headgroups are oriented parallel to the long edge of the ribbons. The structure thus possesses a high cohesion and good crystallinity, and for the first time, we could relate the packing of the chiral molecules to the expression of the chirality at a mesoscopic scale. The organization of the ribbons at the molecular level sheds light on a number of their macroscopic features. Among these are the reason why enantiomerically pure 16-2-16 tartrate forms ribbons that consist of exactly two bilayers, and a plausible mechanism by which a chirally twisted or helical shape may emerge from the packing of chiral tartrate ions. Importantly, the distinction between commonly observed helical and twisted morphologies could be related to a subtle symmetry breaking. These results demonstrate that accurately solving the molecular structure of self-assembled soft materials--a process rarely achieved--is within reach, that it is a valid approach to correlate molecular parameters to macroscopic properties, and thus that it offers opportunities to modulate properties through molecular design.

Structural and stratigraphic framework and spatial distribution of permeability of the Atlantic coastal plain, North Carolina to New York

USGS Publications Warehouse

Brown, Philip Monroe; Miller, James A.; Swain, Frederick Morrill

1972-01-01

This report describes and interprets the results of a detailed subsurface mapping program undertaken in that part of the Atlantic Coastal Plain which extends from the South Carolina and North Carolina border through Long Island, N.Y. Data obtained from more than 2,200 wells are analyzed. Seventeen chronostratigraphic units are mapped in the subsurface. They range in age from Jurassic(?) to post-Miocene. The purpose of the mapping program was to determine the external and internal geometry of mappable chronostratigraphic units and to derive and construct a permeability-distribution network for each unit based upon contrasts in the textures and compositions of its contained sediments. The report contains a structure map and a combined isopach, lithofacies, and permeability-distribution map for each of the chronostratigraphic units delineated in the subsurface. In addition, it contains a map of the top of the basement surface. These maps, together with 36 stratigraphic cross sections, present a three-dimensional view of the regional subsurface hydrogeology. They provide focal points of reference for a discussion of regional tectonics, structure, stratigraphy, and permeability distribution. Taken together and in chronologic sequence, the maps constitute a detailed sedimentary model, the first such model to be constructed for the middle Atlantic Coastal Plain. The chronostratigraphic units mapped record a structural history dominated by lateral and vertical movement along a system of intersecting hinge zones. Taphrogeny, related to transcurrent faulting, is the dominant type of deformation that controlled the geometry of the sedimentary model. Twelve of the seventeen chronostratigraphic units mapped have depositional alinements and thickening trends that are independent of the present-day configuration of the underlying basement surface. These 12 units, classified as genetically unrooted units, are assigned to a first-order tectonic stage. A structural model is proposed whose alinements of positive and negative structural features are accordant with the depositional geometry of the chronostratigraphic units assigned to this tectonic stage. The dominant features of the structural model are northeast-plunging half grabens arranged en echelon and bordered by northeast-plunging fault-block anticlines. Tension-type hinge zones that strike north lie athwart the half grabens. Five of the seventeen chronostratigraphic units mapped have depositional alinements and thickening trends that are accordant with the present-day configuration of the underlying basement surface. These five units, classified as genetically rooted units, are assigned to a second-order tectonic stage. A structural model is proposed whose alinements of positive and negative features are accordant with the depositional geometry of the chronostratigraphic units assigned to this tectonic stage. The dominant feature of this model is a graben that stands tangential to southeast-plunging asymmetrical anticlines. Tension-type hinge zones that strike northeast lie athwart the graben. To account for the semiperiodic realinement of structural features that has characterized the history of the region and as a working hypothesis, we propose that the dominant tectonic element, which is present in the area between north Florida and Long Island, N.Y., is a unit-structural block, a ?basement? block, bounded by wrench-fault zones. We propose that forces derived principally from the rotation and precession of the earth act on the unit-structural block and deform it. Two tectonic models are proposed. One model is compatible with the structural and sedimentary geometries that are associated with chronostratigraphic units assigned to a first-order tectonic stage. It features tension-type hinge zones that strike north and shear-type hinge zones that strike northeast. The other model is compatible with the structural and sedimentary geometries associated with chronostratigraphi

Applications of Parallel Computation in Micro-Mechanics and Finite Element Method

NASA Technical Reports Server (NTRS)

Tan, Hui-Qian

1996-01-01

This project discusses the application of parallel computations related with respect to material analyses. Briefly speaking, we analyze some kind of material by elements computations. We call an element a cell here. A cell is divided into a number of subelements called subcells and all subcells in a cell have the identical structure. The detailed structure will be given later in this paper. It is obvious that the problem is "well-structured". SIMD machine would be a better choice. In this paper we try to look into the potentials of SIMD machine in dealing with finite element computation by developing appropriate algorithms on MasPar, a SIMD parallel machine. In section 2, the architecture of MasPar will be discussed. A brief review of the parallel programming language MPL also is given in that section. In section 3, some general parallel algorithms which might be useful to the project will be proposed. And, combining with the algorithms, some features of MPL will be discussed in more detail. In section 4, the computational structure of cell/subcell model will be given. The idea of designing the parallel algorithm for the model will be demonstrated. Finally in section 5, a summary will be given.

Morphometric analysis of astrocytes in brainstem respiratory regions.

PubMed

Sheikhbahaei, Shahriar; Morris, Brian; Collina, Jared; Anjum, Sommer; Znati, Sami; Gamarra, Julio; Zhang, Ruli; Gourine, Alexander V; Smith, Jeffrey C

2018-06-11

Astrocytes, the most abundant and structurally complex glial cells of the central nervous system, are proposed to play an important role in modulating the activities of neuronal networks, including respiratory rhythm-generating circuits of the preBötzinger complex (preBötC) located in the ventrolateral medulla of the brainstem. However, structural properties of astrocytes residing within different brainstem regions are unknown. In this study astrocytes in the preBötC, an intermediate reticular formation (IRF) region with respiratory-related function, and a region of the nucleus tractus solitarius (NTS) in adult rats were reconstructed and their morphological features were compared. Detailed morphological analysis revealed that preBötC astrocytes are structurally more complex than those residing within the functionally distinct neighboring IRF region, or the NTS, located at the dorsal aspect of the medulla oblongata. Structural analyses of the brainstem microvasculature indicated no significant regional differences in vascular properties. We hypothesize that high morphological complexity of preBötC astrocytes reflects their functional role in providing structural/metabolic support and modulation of the key neuronal circuits essential for breathing, as well as constraints imposed by arrangements of associated neurons and/or other local structural features of the brainstem parenchyma. This article is protected by copyright. All rights reserved. © 2018 Wiley Periodicals, Inc.

Characterization of Isomeric Glycans by Reversed Phase Liquid Chromatography-Electronic Excitation Dissociation Tandem Mass Spectrometry

NASA Astrophysics Data System (ADS)

Tang, Yang; Wei, Juan; Costello, Catherine E.; Lin, Cheng

2018-04-01

The occurrence of numerous structural isomers in glycans from biological sources presents a severe challenge for structural glycomics. The subtle differences among isomeric structures demand analytical methods that can provide structural details while working efficiently with on-line glycan separation methods. Although liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful tool for mixture analysis, the commonly utilized collision-induced dissociation (CID) method often does not generate a sufficient number of fragments at the MS2 level for comprehensive structural characterization. Here, we studied the electronic excitation dissociation (EED) behaviors of metal-adducted, permethylated glycans, and identified key spectral features that could facilitate both topology and linkage determinations. We developed an EED-based, nanoscale, reversed phase (RP)LC-MS/MS platform, and demonstrated its ability to achieve complete structural elucidation of up to five structural isomers in a single LC-MS/MS analysis. [Figure not available: see fulltext.

Epidemic patch models applied to pandemic influenza: contact matrix, stochasticity, robustness of predictions.

PubMed

Lunelli, Antonella; Pugliese, Andrea; Rizzo, Caterina

2009-07-01

Due to the recent emergence of H5N1 virus, the modelling of pandemic influenza has become a relevant issue. Here we present an SEIR model formulated to simulate a possible outbreak in Italy, analysing its structure and, more generally, the effect of including specific details into a model. These details regard population heterogeneities, such as age and spatial distribution, as well as stochasticity, that regulates the epidemic dynamics when the number of infectives is low. We discuss and motivate the specific modelling choices made when building the model and investigate how the model details influence the predicted dynamics. Our analysis may help in deciding which elements of complexity are worth including in the design of a deterministic model for pandemic influenza, in a balance between, on the one hand, keeping the model computationally efficient and the number of parameters low and, on the other hand, maintaining the necessary realistic features.

The Interaction of Global Biochemical Cycles

NASA Technical Reports Server (NTRS)

Moore, B., III; Dastoor, M. N.

1984-01-01

The global biosphere in an exceedingly complex system. To gain an understanding of its structure and dynamic features, it is necessary not only to increase the knowledge about the detailed processes but also to develop models of how global interactions take place. Attempts to analyze the detailed physical, chemical and biological processes in this context need to be guided by an advancement of understanding of the latter. It is necessary to develop a strategy of data gathering that severs both these purposes simultaneously. The following papers deal with critical aspects in the global cycles of carbon, nitrogen, phosphorus and sulfur in details as well as the cycle of water and the flow of energy in the Earth's environment. The objective is to set partly the foundation for the development of mathematical models that allow exploration of the coupled dynamics of the global cycles of carbon, nitrogen, phosphorus, sulfur, as well as energy and water flux.

Exploitation of ERTS-1 imagery utilizing snow enhancement techniques

NASA Technical Reports Server (NTRS)

Wobber, F. J.; Martin, K. R.

1973-01-01

Photogeological analysis of ERTS-simulation and ERTS-1 imagery of snowcovered terrain within the ERAP Feather River site and within the New England (ERTS) test area provided new fracture detail which does not appear on available geological maps. Comparative analysis of snowfree ERTS-1 images has demonstrated that MSS Bands 5 and 7 supply the greatest amount of geological fracture detail. Interpretation of the first snow-covered ERTS-1 images in correlation with ground snow depth data indicates that a heavy blanket of snow (more than 9 inches) accentuates major structural features while a light "dusting", (less than 1 inch) accentuates more subtle topographic expressions. An effective mail-based method for acquiring timely ground-truth (snowdepth) information was established and provides a ready correlation of fracture detail with snow depth so as to establish the working limits of the technique. The method is both efficient and inexpensive compared with the cost of similarly scaled direct field observations.

Mobile Food Ordering Application using Android OS Platform

NASA Astrophysics Data System (ADS)

Yosep Ricky, Michael

2014-03-01

The purpose of this research is making an ordering food application based on Android with New Order, Order History, Restaurant Profile, Order Status, Tracking Order, and Setting Profile features. The research method used in this research is water model of System Development Life Cycle (SDLC) method with following phases: requirement definition, analyzing and determining the features needed in developing application and making the detail definition of each features, system and software design, designing the flow of developing application by using storyboard design, user experience design, Unified Modeling Language (UML) design, and database structure design, implementation an unit testing, making database and translating the result of designs to programming language code then doing unit testing, integration and System testing, integrating unit program to one unit system then doing system testing, operation and maintenance, operating the result of system testing and if any changes and reparations needed then the previous phases could be back. The result of this research is an ordering food application based on Android for customer and courier user, and a website for restaurant and admin user. The conclusion of this research is to help customer in making order easily, to give detail information needed by customer, to help restaurant in receiving order, and to help courier while doing delivery.

Capturing and modelling high-complex alluvial topography with UAS-borne laser scanning

NASA Astrophysics Data System (ADS)

Mandlburger, Gottfried; Wieser, Martin; Pfennigbauer, Martin

2015-04-01

Due to fluvial activity alluvial forests are zones of highest complexity and relief energy. Alluvial forests are dominated by new and pristine channels in consequence of current and historic flood events. Apart from topographic features, the vegetation structure is typically very complex featuring, both, dense under story as well as high trees. Furthermore, deadwood and debris carried from upstream during periods of high discharge within the river channel are deposited in these areas. Therefore, precise modelling of the micro relief of alluvial forests using standard tools like Airborne Laser Scanning (ALS) is hardly feasible. Terrestrial Laser Scanning (TLS), in turn, is very time consuming for capturing larger areas as many scan positions are necessary for obtaining complete coverage due to view occlusions in the forest. In the recent past, the technological development of Unmanned Arial Systems (UAS) has reached a level that light-weight survey-grade laser scanners can be operated from these platforms. For capturing alluvial topography this could bridge the gap between ALS and TLS in terms of providing a very detailed description of the topography and the vegetation structure due to the achievable very high point density of >100 points per m2. In our contribution we demonstrate the feasibility to apply UAS-borne laser scanning for capturing and modelling the complex topography of the study area Neubacher Au, an alluvial forest at the pre-alpine River Pielach (Lower Austria). The area was captured with Riegl's VUX-1 compact time-of-flight laser scanner mounted on a RiCopter (X-8 array octocopter). The scanner features an effective scan rate of 500 kHz and was flown in 50-100 m above ground. At this flying height the laser footprint is 25-50 mm allowing mapping of very small surface details. Furthermore, online waveform processing of the backscattered laser energy enables the retrieval of multiple targets for single laser shots resulting in a dense point cloud of, both, the ground surface and the alluvial vegetation. From the acquired point cloud the following products could be derived: (i) a very high resolution Digital Terrain Model (10 cm raster), (ii) a high resolution model of the water surface of the River Pielach (especially useful for validation of topo-bathymetry LiDAR data) and (iii) a detailed description of the complex vegetation structure.

Deep X-ray Observations of an Ongoing Merger and 400 Myr of AGN Activity in Cygnus A

NASA Astrophysics Data System (ADS)

Wise, Michael W.; De Vries, Martijn; Nulsen, Paul; Snios, Bradford; Birkinshaw, Mark; Worrall, Diana; Duffy, Ryan; Halbesma, Timo; Donnert, Julius; Hardcastle, Martin

2017-08-01

We present a detailed spatial and spectral analysis of the large-scale X-ray emission associated with the merging cluster of galaxies containing the powerful Cygnus A radio galaxy. Using a new 1 Msec exposure from the ongoing Chandra XVP project, we have mapped the large-scale structure, temperature and abundance of the ICM in a 1 Mpc x 1 Mpc region surrounding Cygnus A. This new, deep exposure resolves unprecedented detail in the jets, lobes, and cocoon shock associated with Cygnus A, and provides new insights into the emission mechanisms that produce these features as well as implications for the ongoing activity of the central AGN. On larger scales, these new data reveal complex and dramatic temperature, pressure, entropy and metallicity structure in the ICM surrounding Cygnus A. We confirm the presence of large-scale X-ray emission associated with the two merging cluster components seen previously in lower resolution data. The temperature structure on the scale of the merger exhibits an asymmetric enhancement to the NW consistent with projected hotter gas from the merger shock. Using the derived density and temperature profiles in the two merging sub-cluster components as inputs, we have constructed a grid of hydro-dynamical simulations to constrain the geometry of the merger system. These models imply a pre-merger system with a 1:1 mass ratio at the virial radius with an inclination toward the line of sight of 35-45 deg. In addition to the merger-induced temperature asymmetry, we find evidence for additional surface brightness and temperature features indicative of previous outburst activity in Cygnus A over the past 400 Myr. Based on the location and strength of these features, we derive the energy associated with these previous outbursts and place constraints on the growth of the black hole in Cygnus A over that timescale.

Mapping the Sedna-Lavinia Region of Venus

NASA Technical Reports Server (NTRS)

Campbell, Bruce A.; Anderson, Ross F.

2008-01-01

Geologic mapping of Venus at 1:5 M scale has shown in great detail the flow complexes of volcanoes, coronae, and shield fields, and the varying structural patterns that differentiate tesserae from corona rims and isolated patches of densely lineated terrain. In most cases, however, the lower-elevation plains between the higher-standing landforms are discriminated only on the basis of potentially secondary features such as late-stage lava flooding or tectonic overprinting. This result, in which volcanoes and tesserae appear as "islands in the sea," places weak constraints on the relative age of large upland regions and the nature of the basement terrain. In this work, we focus on the spatial distribution and topography of densely lineated and tessera units over a large region of Venus, and their relationship to apparently later corona and shield flow complexes. The goal is to identify likely connections between patches of deformed terrain that suggest earlier features of regional extent, and to compare the topography of linked patches with other such clusters as a guide to whether they form larger tracts beneath the plains. Mapping Approach. We are mapping the region from 57S to 57N, 300E-60E. Since the 1:5 M quadrangles emphasize detail of tessera structure and corona/edifice flows, we simply adopt the outlines of these features as they relate to the outcrops of either "densely lineated terrain" or tessera (Fig. 1). The densely lineated material is mapped in many quadrangles based on pervasive structural deformation, typically with a single major axis (in contrast to the overlapping orthogonal patterns on tesserae). This unit definition is often extended to include material of corona rims. We do not at present differentiate between plains units, since earlier efforts show that their most defining attributes may be secondary to the original emplacement (e.g., lobate or sheet-like flooding by thin flow units, tectonic patterns related to regional and localized stress regimes) [1].

Topographic and sedimentary features in the Yap subduction zone and their implications for the Caroline Ridge subduction

NASA Astrophysics Data System (ADS)

Dong, Dongdong; Zhang, Zhengyi; Bai, Yongliang; Fan, Jianke; Zhang, Guangxu

2018-01-01

The Yap subduction zone in the western Pacific presents some unique features compared to normal intra-oceanic subduction zones such as the subduction of an oceanic plateau. However, due to the relative paucity of geophysical data, the detailed structure remains unknown in this area. In this study, we present the latest high-quality swath bathymetry and multi-channel seismic data acquired synchronously in 2015 across the Yap subduction zone. The topographic and sedimentary features are intensively investigated and a modified evolutionary model of the Yap subduction zone is proposed. The two-stage evolution of the Parece Vela Basin (PVB) produced fabrics that are N-S trending and NW-SE trending. Our seismic data clearly reveal landslide deposits at the upper slope break of the forearc, to the north of the Yap Island, which was identified as the fault notch denoting a lithological boundary in previous work. The swath bathymetry and seismic profile reveal detailed horst and graben structures, including a crescent-shaped fault zone near the contact between the Yap Trench and the Caroline Ridge. A simple geometric model is proposed to explain the structure formation, indicating that the higher topography of the Caroline Ridge resulted in enhanced bending-related extension. A seismic angular unconformity (named R1) is identified in the Sorol Trough, marking the onset of rifting in the trough. Based on the sequence thickness and deposition rate by Deep Sea Drilling Project (DSDP), it is deduced that the Sorol Trough formed at 10 Ma or even earlier. A modified model for the Yap subduction zone evolution is proposed, incorporating three major tectonic events: the proto-Yap Arc rupture in the Oligocene, the collision of the Caroline Ridge and the Yap Trench in the late Oligocene or middle Miocene, and the onset of the Sorol Trough rifting in the late Miocene.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoak, T.E.; Decker, A.D.

Mesaverde Group reservoirs in the Piceance Basin, Western Colorado contain a large reservoir base. Attempts to exploit this resource base are stymied by low permeability reservoir conditions. The presence of abundant natural fracture systems throughout this basin, however, does permit economic production. Substantial production is associated with fractured reservoirs in Divide Creek, Piceance Creek, Wolf Creek, White River Dome, Plateau, Shire Gulch, Grand Valley, Parachute and Rulison fields. Successful Piceance Basin gas production requires detailed information about fracture networks and subsurface gas and water distribution in an overall gas-centered basin geometry. Assessment of these three parameters requires an integrated basinmore » analysis incorporating conventional subsurface geology, seismic data, remote sensing imagery analysis, and an analysis of regional tectonics. To delineate the gas-centered basin geometry in the Piceance Basin, a regional cross-section spanning the basin was constructed using hydrocarbon and gamma radiation logs. The resultant hybrid logs were used for stratigraphic correlations in addition to outlining the trans-basin gas-saturated conditions. The magnitude of both pressure gradients (paludal and marine intervals) is greater than can be generated by a hydrodynamic model. To investigate the relationships between structure and production, detailed mapping of the basin (top of the Iles Formation) was used to define subtle subsurface structures that control fractured reservoir development. The most productive fields in the basin possess fractured reservoirs. Detailed studies in the Grand Valley-Parachute-Rulison and Shire Gulch-Plateau fields indicate that zones of maximum structural flexure on kilometer-scale structural features are directly related to areas of enhanced production.« less

Detail view to show the stylized "dragon" bracket feature that ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view to show the stylized "dragon" bracket feature that stands guard by the outside door to the kitchen (north elevation of the main house) - Death Valley Ranch, Main House, Death Valley Junction, Inyo County, CA

Detail of decorative panel featuring a monkey at Ten Mile ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of decorative panel featuring a monkey at Ten Mile River Playground comfort station, looking northwest. - Henry Hudson Parkway, Extending 11.2 miles from West 72nd Street to Bronx-Westchester border, New York County, NY

Global Cost and Weight Evaluation of Fuselage Side Panel Design Concepts

NASA Technical Reports Server (NTRS)

Polland, D. R.; Finn, S. R.; Griess, K. H.; Hafenrichter, J. L.; Hanson, C. T.; Ilcewicz, L. B.; Metschan, S. L.; Scholz, D. B.; Smith, P. J.

1997-01-01

This report documents preliminary design trades conducted under NASA contracts NAS1 18889 (Advanced Technology Composite Aircraft Structures, ATCAS) and NAS1-19349 (Task 3, Pathfinder Shell Design) for a subsonic wide body commercial aircraft fuselage side panel section utilizing composite materials. Included in this effort were (1) development of two complete design concepts, (2) generation of cost and weight estimates, (3) identification of technical issues and potential design enhancements, and (4) selection of a single design to be further developed. The first design concept featured an open-section stringer stiffened skin configuration while the second was based on honeycomb core sandwich construction. The trade study cost and weight results were generated from comprehensive assessment of each structural component comprising the fuselage side panel section from detail fabrication through airplane final assembly. Results were obtained in three phases: (1) for the baseline designs, (2) after global optimization of the designs, and (3) the results anticipated after detailed design optimization. A critical assessment of both designs was performed to determine the risk associated with each concept, that is the relative probability of achieving the cost and weight projections. Seven critical technical issues were identified as the first step towards side panel detailed design optimization.

Self-assembly of Zn(salphen) complexes: steric regulation, stability studies and crystallographic analysis revealing an unexpected dimeric 3,3'-t-Bu-substituted Zn(salphen) complex.

PubMed

Martínez Belmonte, Marta; Wezenberg, Sander J; Haak, Robert M; Anselmo, Daniele; Escudero-Adán, Eduardo C; Benet-Buchholz, Jordi; Kleij, Arjan W

2010-05-21

The self-assembly features of a series of (non)symmetrical Zn(salphen) complexes have been studied in detail by X-ray crystallography, NMR and UV-vis techniques. The combined data demonstrate that the stability of these dimeric assemblies and the relative position of each monomeric unit within the dinuclear structure depend on the location and combination of the aromatic ring substituents.

Mars gravity: high-resolution results from viking orbiter 2.

PubMed

Sjogren, W L

1979-03-09

Doppler radio-tracking data have provided detailed measurements for a martian gravity map extending from 30 degrees S to 65 degrees N in latitude and through 360 degrees of longitude. The feature resolution is approximately 500 kilometers, revealing a huge anomaly associated with Olympus Mons, a mascon in Isidis Planitia, and other anomalies correlated with volcanic structure. Olympus Mons has been modeled with a 600-kilometer surface disk having a mass of 8.7 x 1021grams.

Skin friction fields on delta wings

NASA Astrophysics Data System (ADS)

Woodiga, S. A.; Liu, Tianshu

2009-12-01

The normalized skin friction fields on a 65° delta wing and a 76°/40° double-delta wing are measured by using a global luminescent oil-film skin friction meter. The detailed topological structures of skin friction fields on the wings are revealed for different angles of attack and the important features are detected such as reattachment lines, secondary separation lines, vortex bursting and vortex interaction. The comparisons with the existing flow visualization results are discussed.

Linking macroscopic with microscopic neuroanatomy using synthetic neuronal populations.

PubMed

Schneider, Calvin J; Cuntz, Hermann; Soltesz, Ivan

2014-10-01

Dendritic morphology has been shown to have a dramatic impact on neuronal function. However, population features such as the inherent variability in dendritic morphology between cells belonging to the same neuronal type are often overlooked when studying computation in neural networks. While detailed models for morphology and electrophysiology exist for many types of single neurons, the role of detailed single cell morphology in the population has not been studied quantitatively or computationally. Here we use the structural context of the neural tissue in which dendritic trees exist to drive their generation in silico. We synthesize the entire population of dentate gyrus granule cells, the most numerous cell type in the hippocampus, by growing their dendritic trees within their characteristic dendritic fields bounded by the realistic structural context of (1) the granule cell layer that contains all somata and (2) the molecular layer that contains the dendritic forest. This process enables branching statistics to be linked to larger scale neuroanatomical features. We find large differences in dendritic total length and individual path length measures as a function of location in the dentate gyrus and of somatic depth in the granule cell layer. We also predict the number of unique granule cell dendrites invading a given volume in the molecular layer. This work enables the complete population-level study of morphological properties and provides a framework to develop complex and realistic neural network models.

Linking Macroscopic with Microscopic Neuroanatomy Using Synthetic Neuronal Populations

PubMed Central

Schneider, Calvin J.; Cuntz, Hermann; Soltesz, Ivan

2014-01-01

Dendritic morphology has been shown to have a dramatic impact on neuronal function. However, population features such as the inherent variability in dendritic morphology between cells belonging to the same neuronal type are often overlooked when studying computation in neural networks. While detailed models for morphology and electrophysiology exist for many types of single neurons, the role of detailed single cell morphology in the population has not been studied quantitatively or computationally. Here we use the structural context of the neural tissue in which dendritic trees exist to drive their generation in silico. We synthesize the entire population of dentate gyrus granule cells, the most numerous cell type in the hippocampus, by growing their dendritic trees within their characteristic dendritic fields bounded by the realistic structural context of (1) the granule cell layer that contains all somata and (2) the molecular layer that contains the dendritic forest. This process enables branching statistics to be linked to larger scale neuroanatomical features. We find large differences in dendritic total length and individual path length measures as a function of location in the dentate gyrus and of somatic depth in the granule cell layer. We also predict the number of unique granule cell dendrites invading a given volume in the molecular layer. This work enables the complete population-level study of morphological properties and provides a framework to develop complex and realistic neural network models. PMID:25340814

Ultrastructural analysis of testicular tissue and sperm by transmission and scanning electron microscopy.

PubMed

Chemes, Hector E

2013-01-01

Transmission electron microscopy (TEM) studies have provided the basis for an in-depth understanding of the cell biology and normal functioning of the testis and male gametes and have opened the way to characterize the functional role played by specific organelles in spermatogenesis and sperm function. The development of the scanning electron microscope (SEM) extended these boundaries to the recognition of cell and organ surface features and the architectural array of cells and tissues. The merging of immunocytochemical and histochemical approaches with electron microscopy has completed a series of technical improvements that integrate structural and functional features to provide a broad understanding of cell biology in health and disease. With these advances the detailed study of the intricate structural and molecular organization as well as the chemical composition of cellular organelles is now possible. Immunocytochemistry is used to identify proteins or other components and localize them in specific cells or organelles with high specificity and sensitivity, and histochemistry can be used to understand their function (i.e., enzyme activity). When these techniques are used in conjunction with electron microscopy their resolving power is further increased to subcellular levels. In the present chapter we will describe in detail various ultrastructural techniques that are now available for basic or translational research in reproductive biology and reproductive medicine. These include TEM, ultrastructural immunocytochemistry, ultrastructural histochemistry, and SEM.

Interdomain Contacts Control Native State Switching of RfaH on a Dual-Funneled Landscape

PubMed Central

Ramírez-Sarmiento, César A.; Noel, Jeffrey K.; Valenzuela, Sandro L.; Artsimovitch, Irina

2015-01-01

RfaH is a virulence factor from Escherichia coli whose C-terminal domain (CTD) undergoes a dramatic α-to-β conformational transformation. The CTD in its α-helical fold is stabilized by interactions with the N-terminal domain (NTD), masking an RNA polymerase binding site until a specific recruitment site is encountered. Domain dissociation is triggered upon binding to DNA, allowing the NTD to interact with RNA polymerase to facilitate transcription while the CTD refolds into the β-barrel conformation that interacts with the ribosome to activate translation. However, structural details of this transformation process in the context of the full protein remain to be elucidated. Here, we explore the mechanism of the α-to-β conformational transition of RfaH in the full-length protein using a dual-basin structure-based model. Our simulations capture several features described experimentally, such as the requirement of disruption of interdomain contacts to trigger the α-to-β transformation, confirms the roles of previously indicated residues E48 and R138, and suggests a new important role for F130, in the stability of the interdomain interaction. These native basins are connected through an intermediate state that builds up upon binding to the NTD and shares features from both folds, in agreement with previous in silico studies of the isolated CTD. We also examine the effect of RNA polymerase binding on the stabilization of the β fold. Our study shows that native-biased models are appropriate for interrogating the detailed mechanisms of structural rearrangements during the dramatic transformation process of RfaH. PMID:26230837

Seeking instructional specificity: An example from analogical instruction

NASA Astrophysics Data System (ADS)

Kuo, Eric; Wieman, Carl E.

2015-12-01

Broad instructional methods like "interactive engagement" have been shown to be effective, but such general characterization provides little guidance on the details of how to structure instructional materials. In this study, we seek instructional specificity by comparing two ways of using an analogy to learn a target physical principle: (i) applying the analogy to the target physical domain on a case-by-case basis and (ii) using the analogy to create a general rule in the target physical domain. In the discussion sections of a large, introductory physics course (N =2 3 1 ), students who sought a general rule were better able to discover and apply a correct physics principle than students who analyzed the examples case by case. The difference persisted at a reduced level after subsequent direct instruction. We argue that students who performed case-by-case analyses were more likely to focus on idiosyncratic problem-specific features rather than the deep structural features. This study provides an example of investigations into how the specific structure of instructional materials can be consequential for what is learned.

Insights into structural features determining odorant affinities to honey bee odorant binding protein 14.

PubMed

Schwaighofer, Andreas; Pechlaner, Maria; Oostenbrink, Chris; Kotlowski, Caroline; Araman, Can; Mastrogiacomo, Rosa; Pelosi, Paolo; Knoll, Wolfgang; Nowak, Christoph; Larisika, Melanie

2014-04-18

Molecular interactions between odorants and odorant binding proteins (OBPs) are of major importance for understanding the principles of selectivity of OBPs towards the wide range of semiochemicals. It is largely unknown on a structural basis, how an OBP binds and discriminates between odorant molecules. Here we examine this aspect in greater detail by comparing the C-minus OBP14 of the honey bee (Apis mellifera L.) to a mutant form of the protein that comprises the third disulfide bond lacking in C-minus OBPs. Affinities of structurally analogous odorants featuring an aromatic phenol group with different side chains were assessed based on changes of the thermal stability of the protein upon odorant binding monitored by circular dichroism spectroscopy. Our results indicate a tendency that odorants show higher affinity to the wild-type OBP suggesting that the introduced rigidity in the mutant protein has a negative effect on odorant binding. Furthermore, we show that OBP14 stability is very sensitive to the position and type of functional groups in the odorant. Copyright © 2014 Elsevier Inc. All rights reserved.

Optimization of the structural characteristics of CaO and its effective stabilization yield high-capacity CO2 sorbents.

PubMed

Naeem, Muhammad Awais; Armutlulu, Andac; Imtiaz, Qasim; Donat, Felix; Schäublin, Robin; Kierzkowska, Agnieszka; Müller, Christoph R

2018-06-19

Calcium looping, a CO 2 capture technique, may offer a mid-term if not near-term solution to mitigate climate change, triggered by the yet increasing anthropogenic CO 2 emissions. A key requirement for the economic operation of calcium looping is the availability of highly effective CaO-based CO 2 sorbents. Here we report a facile synthesis route that yields hollow, MgO-stabilized, CaO microspheres featuring highly porous multishelled morphologies. As a thermal stabilizer, MgO minimized the sintering-induced decay of the sorbents' CO 2 capacity and ensured a stable CO 2 uptake over multiple operation cycles. Detailed electron microscopy-based analyses confirm a compositional homogeneity which is identified, together with the characteristics of its porous structure, as an essential feature to yield a high-performance sorbent. After 30 cycles of repeated CO 2 capture and sorbent regeneration, the best performing material requires as little as 11 wt.% MgO for structural stabilization and exceeds the CO 2 uptake of the limestone-derived reference material by ~500%.

Asymmetric hindwing foldings in rove beetles.

PubMed

Saito, Kazuya; Yamamoto, Shuhei; Maruyama, Munetoshi; Okabe, Yoji

2014-11-18

Foldable wings of insects are the ultimate deployable structures and have attracted the interest of aerospace engineering scientists as well as entomologists. Rove beetles are known to fold their wings in the most sophisticated ways that have right-left asymmetric patterns. However, the specific folding process and the reason for this asymmetry remain unclear. This study reveals how these asymmetric patterns emerge as a result of the folding process of rove beetles. A high-speed camera was used to reveal the details of the wing-folding movement. The results show that these characteristic asymmetrical patterns emerge as a result of simultaneous folding of overlapped wings. The revealed folding mechanisms can achieve not only highly compact wing storage but also immediate deployment. In addition, the right and left crease patterns are interchangeable, and thus each wing internalizes two crease patterns and can be folded in two different ways. This two-way folding gives freedom of choice for the folding direction to a rove beetle. The use of asymmetric patterns and the capability of two-way folding are unique features not found in artificial structures. These features have great potential to extend the design possibilities for all deployable structures, from space structures to articles of daily use.

[A family of short retroposons (Squaml) from squamate reptiles (Reptilia: Squamata): structure, evolution and correlation with phylogeny].

PubMed

Kosushkin, S A; Borodulina, O R; Solov'eva, E N; Grechko, V V

2008-01-01

We have isolated and characterised sequences of a SINE family specific for squamate reptiles from a genome of lacertid lizard that we called Squam1. Copies are 360-390 bp in length and share a significant similarity with tRNA gene sequence on its 5'-end. This family was also detected by us in DNA of representatives of varanids, iguanids (anolis), gekkonids, and snakes. No signs of it were found in DNA of mammals, birds, amphibians, and crocodiles. Detailed analysis of primary structure of the retroposons obtained by us from genomic libraries or GenBank sequences was carried out. Most taxa possess 2-3 subfamilies of the SINE in their genomes with specific diagnostic features in their primary structure. Individual variability of copies in different families is about 85% and is just slightly lower on the genera level. Comparison of consensus sequences on family level reveals a high degree of structural similarity with a number of specific apomorphic features which makes it a useful marker of phylogeny for this group of reptiles. Snakes do not show specific affinity to varanids when compared to other lizards, as it was suggested earlier.

Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions.

PubMed

Cau, Ylenia; Fiorillo, Annarita; Mori, Mattia; Ilari, Andrea; Botta, Maurizo; Lalle, Marco

2015-12-28

Giardiasis is a gastrointestinal diarrheal illness caused by the protozoan parasite Giardia duodenalis, which affects annually over 200 million people worldwide. The limited antigiardial drug arsenal and the emergence of clinical cases refractory to standard treatments dictate the need for new chemotherapeutics. The 14-3-3 family of regulatory proteins, extensively involved in protein-protein interactions (PPIs) with pSer/pThr clients, represents a highly promising target. Despite homology with human counterparts, the single 14-3-3 of G. duodenalis (g14-3-3) is characterized by a constitutive phosphorylation in a region critical for target binding, thus affecting the function and the conformation of g14-3-3/clients interaction. However, to approach the design of specific small molecule modulators of g14-3-3 PPIs, structural elucidations are required. Here, we present a detailed computational and crystallographic study exploring the implications of g14-3-3 phosphorylation on protein structure and target binding. Self-Guided Langevin Dynamics and classical molecular dynamics simulations show that phosphorylation affects locally and globally g14-3-3 conformation, inducing a structural rearrangement more suitable for target binding. Profitable features for g14-3-3/clients interaction were highlighted using a hydrophobicity-based descriptor to characterize g14-3-3 client peptides. Finally, the X-ray structure of g14-3-3 in complex with a mode-1 prototype phosphopeptide was solved and combined with structure-based simulations to identify molecular features relevant for clients binding to g14-3-3. The data presented herein provide a further and structural understanding of g14-3-3 features and set the basis for drug design studies.

An investigation of the temporal character of mesoscale perturbations in the troposphere and stratosphere

NASA Technical Reports Server (NTRS)

Vaughan, W. W.

1977-01-01

The effectiveness of mesoscale models in explaining perturbations observed in vertical detailed wind profile measurements in the troposphere and lower stratosphere is assessed. The structure and persistence of the data were analyzed and interpreted in terms of several physical models with the goal of establishing explanations for the observed persistent features of the mesoscale flow patterns. The experimental data used in the investigation were obtained by a unique detailed wind profile measurement system. This system is capable of providing resolution of 50 to 100 m wavelengths for the altitude region from approximately 200 m to 18 km. The system consists of a high-resolution tracking radar and special super-pressure balloon configuration known as a Jimsphere.

Phonon and thermodynamical properties of CuSc: A DFT study

NASA Astrophysics Data System (ADS)

Jain, Ekta; Pagare, Gitanjali; Dubey, Shubha; Sanyal, S. P.

2018-05-01

A detailed systematic theoretical investigation of phonon and thermodynamical behavior of CuSc intermetallic compound has been carried out by uing first-principles density functional theory in B2-type (CsCl) crystal structure. Phonon dispersion curve and phonon density of states (PhDOS) are studied which confirm the stability of CuSc intermetallic compound in B2 phase. It is found that PhDOS at high frequencies mostly composed of Sc states. We have also presented some temperature dependent properties such as entropy, free energy, heat capacity, internal energy and thermal displacement, which are computed under PHONON code. The various features of these quantities are discussed in detail. From these results we demonstrate that the particular intermetallic have better ductility and larger thermal expansion.

On the structure and phase transitions of power-law Poissonian ensembles

NASA Astrophysics Data System (ADS)

Eliazar, Iddo; Oshanin, Gleb

2012-10-01

Power-law Poissonian ensembles are Poisson processes that are defined on the positive half-line, and that are governed by power-law intensities. Power-law Poissonian ensembles are stochastic objects of fundamental significance; they uniquely display an array of fractal features and they uniquely generate a span of important applications. In this paper we apply three different methods—oligarchic analysis, Lorenzian analysis and heterogeneity analysis—to explore power-law Poissonian ensembles. The amalgamation of these analyses, combined with the topology of power-law Poissonian ensembles, establishes a detailed and multi-faceted picture of the statistical structure and the statistical phase transitions of these elemental ensembles.

Multistep modeling of protein structure: application to bungarotoxin

NASA Technical Reports Server (NTRS)

Srinivasan, S.; Shibata, M.; Rein, R.

1986-01-01

Modelling of bungarotoxin in atomic details is presented in this article. The model-building procedure utilizes the low-resolution crystal coordinates of the c-alpha atoms of bungarotoxin, sequence homology within the neurotoxin family, as well as high-resolution x-ray diffraction data of cobratoxin and erabutoxin. Our model-building procedure involves: (a) principles of comparative modelling, (b) embedding procedures of distance geometry, and (c) use of molecular mechanics for optimizing packing. The model is not only consistent with the c-alpha coordinates of crystal structure, but also agrees with solution conformational features of the triple-stranded beta sheet as observed by NOE measurements.

Martian Clouds Data Workshop

NASA Technical Reports Server (NTRS)

Lee, Steven (Editor)

1987-01-01

The major topics covered were a discussion of the structure of relational data base systems and features of the Britton Lee Relational Data Base Management System (RDBMS); a discussion of the workshop's objectives, approach, and research scenarios; and an overview of the Atmospheres Node User's Guide, which details the datasets stored on the Britton Lee, the structure of the query and data analysis system, and examples of the exact menu screens encountered. Also discussed were experience with the system, review of the system performance, and a strategy to produce queries and performance data retrievals of mutual interest. The goals were defined as examining correlations between cloud occurrence, water vapor abundance, and surface properties.

Use of Small Angle Neutron Scattering to Study Various Properties of Wool and Mohair Fibres

DOE Office of Scientific and Technical Information (OSTI.GOV)

Franklyn, C. B.; Toeroek, Gy.

2011-12-13

To maintain a competitive edge in the wool and mohair industry, a detailed knowledge and understanding of the properties of wool fibres is essential. Standard techniques are used to determine fibre diameter, length and strength; however, properties such as hydroscopicity, lustre and changes in fibre structure following chemical or mechanical treatment are not so well understood. The unique capabilities of small angle neutron scattering to study changes in the supermolecular structure of wool fibres, particularly at the level of the microfibril-matrix complex, have been used to provide previously unknown features of the fibres. The results of these studies are presented.

Relatively stable, large-amplitude Alfvenic waves seen at 2.5 and 5.0 AU

NASA Technical Reports Server (NTRS)

Mavromichalaki, H.; Moussas, X.; Quenby, J. J.; Valdes-Galicia, J. F.; Smith, E. J.

1988-01-01

Pioneer 11 and 10 observations of the wave structure seen in a corotating interaction region at 2.5 AU on day 284 of 1973 and 8 days later at 5 AU reveal large-amplitude Alfvenic structures with many detailed correlations seen between their features at the two radial distances. Hodogram analysis suggests the dominance of near plane polarized, transverse Alfvenic mode fluctuations with periods between 2 min and one hour or more. Some wave evolution close to the Corotating Interaction Region (CIR) shock is noticed, but waves towards the center of the compression seem to propagate with little damping between the spacecraft observation positions.

Structure of caa(3) cytochrome c oxidase--a nature-made enzyme-substrate complex.

PubMed

Noor, Mohamed Radzi; Soulimane, Tewfik

2013-05-01

Aerobic respiration, the energetically most favorable metabolic reaction, depends on the action of terminal oxidases that include cytochrome c oxidases. The latter forms a part of the heme-copper oxidase superfamily and consists of three different families (A, B, and C types). The crystal structures of all families have now been determined, allowing a detailed structural comparison from evolutionary and functional perspectives. The A2-type oxidase, exemplified by the Thermus thermophilus caa(3) oxidase, contains the substrate cytochrome c covalently bound to the enzyme complex. In this article, we highlight the various features of caa(3) enzyme and provide a discussion of their importance, including the variations in the proton and electron transfer pathways.

Trade-offs between robustness and small-world effect in complex networks

PubMed Central

Peng, Guan-Sheng; Tan, Suo-Yi; Wu, Jun; Holme, Petter

2016-01-01

Robustness and small-world effect are two crucial structural features of complex networks and have attracted increasing attention. However, little is known about the relation between them. Here we demonstrate that, there is a conflicting relation between robustness and small-world effect for a given degree sequence. We suggest that the robustness-oriented optimization will weaken the small-world effect and vice versa. Then, we propose a multi-objective trade-off optimization model and develop a heuristic algorithm to obtain the optimal trade-off topology for robustness and small-world effect. We show that the optimal network topology exhibits a pronounced core-periphery structure and investigate the structural properties of the optimized networks in detail. PMID:27853301

High-Resolution Radar Imagery of Mars

NASA Astrophysics Data System (ADS)

Harmon, John K.; Nolan, M. C.

2009-09-01

We present high-resolution radar images of Mars obtained during the 2005 and 2007 oppositions. The images were constructed from long-code delay-Doppler observations made with the Arecibo S-band (13-cm) radar. The average image resolution of 3 km represented a better than order-of-magnitude improvement over pre-upgrade Arecibo imagery of the planet. Images of depolarized reflectivity (an indicator primarily of wavelength-scale surface roughness) show the same bright volcanic flow features seen in earlier imagery, but with much finer detail. A new image of the Elysium region shows fine detail in the radar-bright channels of Athabasca Vallis, Marte Vallis, and Grjota Vallis. The new images of Tharsis and Olympus Mons also show a complex array of radar-bright and radar-dark features. Southern Amazonis exhibits some of the most complex and puzzling radar-bright structure on the planet. Another curiosity is the Chryse/Xanthe/Channels region, where we find some radar-bright features in or adjacent to fluvial chaos structures. Chryse/Xanthe is also the only region of Mars showing radar-bright craters (which are rare on Mars but common on the Moon and Mercury). We also obtained the first delay-Doppler image showing the enhanced backscatter from the residual south polar ice cap. In addition to the depolarized imagery, we were able to make the first delay-Doppler images of the circular polarization ratio (an important diagnostic for surface roughness texture). We find that vast areas of the radar-bright volcanic regions have polarization ratios close to unity. Such high ratios are rare for terrestrial lava flows and only seen for extremely blocky surfaces giving high levels of multiple scattering.

SoFoCles: feature filtering for microarray classification based on gene ontology.

PubMed

Papachristoudis, Georgios; Diplaris, Sotiris; Mitkas, Pericles A

2010-02-01

Marker gene selection has been an important research topic in the classification analysis of gene expression data. Current methods try to reduce the "curse of dimensionality" by using statistical intra-feature set calculations, or classifiers that are based on the given dataset. In this paper, we present SoFoCles, an interactive tool that enables semantic feature filtering in microarray classification problems with the use of external, well-defined knowledge retrieved from the Gene Ontology. The notion of semantic similarity is used to derive genes that are involved in the same biological path during the microarray experiment, by enriching a feature set that has been initially produced with legacy methods. Among its other functionalities, SoFoCles offers a large repository of semantic similarity methods that are used in order to derive feature sets and marker genes. The structure and functionality of the tool are discussed in detail, as well as its ability to improve classification accuracy. Through experimental evaluation, SoFoCles is shown to outperform other classification schemes in terms of classification accuracy in two real datasets using different semantic similarity computation approaches.

Intricate Hollow Structures: Controlled Synthesis and Applications in Energy Storage and Conversion.

PubMed

Zhou, Liang; Zhuang, Zechao; Zhao, Huihui; Lin, Mengting; Zhao, Dongyuan; Mai, Liqiang

2017-05-01

Intricate hollow structures garner tremendous interest due to their aesthetic beauty, unique structural features, fascinating physicochemical properties, and widespread applications. Here, the recent advances in the controlled synthesis are discussed, as well as applications of intricate hollow structures with regard to energy storage and conversion. The synthetic strategies toward complex multishelled hollow structures are classified into six categories, including well-established hard- and soft-templating methods, as well as newly emerging approaches based on selective etching of "soft@hard" particles, Ostwald ripening, ion exchange, and thermally induced mass relocation. Strategies for constructing structures beyond multishelled hollow structures, such as bubble-within-bubble, tube-in-tube, and wire-in-tube structures, are also covered. Niche applications of intricate hollow structures in lithium-ion batteries, Li-S batteries, supercapacitors, Li-O 2 batteries, dye-sensitized solar cells, photocatalysis, and fuel cells are discussed in detail. Some perspectives on the future research and development of intricate hollow structures are also provided. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

EPR spectral investigation of radiation-induced radicals of gallic acid.

PubMed

Tuner, Hasan

2017-11-01

In the present work, spectroscopic features of the radiation-induced radicals of gallic acid compounds were investigated using electron paramagnetic resonance (EPR) spectroscopy. While un-irradiated samples presented no EPR signal, irradiated samples exhibited an EPR spectrum consisting of an intense resonance line at the center and weak lines on both sides. Detailed microwave saturation investigations were carried out to determine the origin of the experimental EPR lines. It is concluded that the two side lines of the triplet satellite originate from forbidden "spin-flip" transitions. The spectroscopic and structural features of the radiation-induced radicals were determined using EPR spectrum fittings. The experimental EPR spectra of the two gallic acid compounds were consistent with the calculated EPR spectroscopic features of the proposed radicals. It is concluded that the most probable radicals are the cyclohexadienyl-type, [Formula: see text] radicals for both compounds.

Petrography of shock features in the 1953 Manson 2-A drill core

NASA Technical Reports Server (NTRS)

Short, N. M.; Gold, D. P.

1993-01-01

Drilling of Nx core in late 1953 into an anomalous zone of disturbed rocks northwest of Manson, Iowa disclosed presence of extensive breccias including crystalline rocks brought to the surface from depths of 4 km or more. Hole 2-A penetrated breccias dominated by leucocratic igneous and metamorphic lithologies, later interpreted to be part of a general ringed peak complex within a 35 km wide impact structure produced about 65 Ma ago. Proof of this origin was given in 1966 by NMS through recognition of shock metamorphic features in 2-A materials during a cursory examination of samples provided by R.A. Hoppin, University of Iowa. A detailed study of this material now underway has revealed that most breccia clasts in 2-A show abundant and varied evidence of shock damage, including extensive planar deformation features (PDF) in quartz, K-feldspar, plagioclase, and a pyroxene and varying degrees of isotropization and incipient melting in feldspars.

Return to Flight Resource Reel 1 of 2

NASA Technical Reports Server (NTRS)

2005-01-01

A video presentation detailing the tests performed on the Space Shuttle Discovery in preparation for its return to flight is shown. The tests include: 1) Reinforced Carbon-Carbon (RCC) Impact Test Article; 2) RCC Foam Impact Testing; 3) Thermal Protection System (TPS) Ice Impact Testing featuring Justin Kerr, Project Engineer; 4) Wing Leading Edge Wireless Sensors featuring Karl Kiefer, President and CEO of Invocon, and Kevin Champaigne of Invocon; 5) TPS Repair Testing KC-135 Zero-G Environment featuring Soichi Noguchi, Mission Specialist; 6) TPS Extravehicular Activity Tool Demonstration; 7) TPS Repair Testing Vacuum Glove box; 8) TPS Repair Testing Human Thermal Vacuum Chamber; 9) TPS Reentry Testing Atmospheric Reentry Materials and Structures Evaluation Facility; 10) TPS Alternative Repair Concept; 11) Lora Bailey Lead Engineer for EVA Tools; 12) Reinforced Carbon-Carbon ATK Thiokol Plug Repair Animation; 13) 3-Percent Model Build-Up; and 14) Wind Tunnel Testing RCC Aging Research Ballistic Testing.

Volcanism offshore of Vesuvius Volcano in Naples Bay

USGS Publications Warehouse

Milia, A.; Mirabile, L.; Torrente, M.M.; Dvorak, J.J.

1998-01-01

High-resolution seismic reflection data are used to identify structural features in Naples Bay near Vesuvius Volcano. Several buried seismic units with reflection-free interiors are probably volcanic deposits erupted during and since the formation of the breached crater of Monte Somma Volcano, which preceded the growth of Vesuvius. The presumed undersea volcanic deposits are limited in extent; thus, stratigraphie relationships cannot be established among them. Other features revealed by our data include (a) the warping of lowstand marine deposits by undersea cryptodomes located approximately 10 km from the summit of Vesuvius, (b) a succession of normal step faults that record seaward collapse of the volcano, and (c) a small undersea slump in the uppermost marine deposits of Naples Bay, which may be the result of nue??e ardentes that entered the sea during a major eruption of Vesuvius in 1631. Detection of these undersea features illustrates some capabilities of making detailed seismic reflection profiles across undersea volcanoes.

Coupled Analysis of In Vitro and Histology Tissue Samples to Quantify Structure-Function Relationship

PubMed Central

Acar, Evrim; Plopper, George E.; Yener, Bülent

2012-01-01

The structure/function relationship is fundamental to our understanding of biological systems at all levels, and drives most, if not all, techniques for detecting, diagnosing, and treating disease. However, at the tissue level of biological complexity we encounter a gap in the structure/function relationship: having accumulated an extraordinary amount of detailed information about biological tissues at the cellular and subcellular level, we cannot assemble it in a way that explains the correspondingly complex biological functions these structures perform. To help close this information gap we define here several quantitative temperospatial features that link tissue structure to its corresponding biological function. Both histological images of human tissue samples and fluorescence images of three-dimensional cultures of human cells are used to compare the accuracy of in vitro culture models with their corresponding human tissues. To the best of our knowledge, there is no prior work on a quantitative comparison of histology and in vitro samples. Features are calculated from graph theoretical representations of tissue structures and the data are analyzed in the form of matrices and higher-order tensors using matrix and tensor factorization methods, with a goal of differentiating between cancerous and healthy states of brain, breast, and bone tissues. We also show that our techniques can differentiate between the structural organization of native tissues and their corresponding in vitro engineered cell culture models. PMID:22479315

Asymmetric activation mechanism of a homodimeric red light regulated photoreceptor.

PubMed

Gourinchas, Geoffrey; Heintz, Udo; Winkler, Andreas

2018-06-05

Organisms adapt to environmental cues using diverse signaling networks. In order to sense and integrate light for regulating various biological functions, photoreceptor proteins have evolved in a modular way. This modularity is targeted in the development of optogenetic tools enabling the control of cellular events with high spatiotemporal precision. However, the limited understanding of signaling mechanisms impedes the rational design of innovative photoreceptor-effector couples. Here we reveal molecular details of signal transduction in phytochrome-regulated diguanylyl-cyclases. Asymmetric structural changes of the full-length homodimer result in a functional heterodimer featuring two different photoactivation states. Structural changes around the cofactors result in a quasi-translational rearrangement of the distant coiled-coil sensor-effector linker. Eventually, this regulates enzymatic activity by modulating the dimer interface of the output domains. Considering the importance of phytochrome heterodimerization in plant signaling, our mechanistic details of asymmetric photoactivation in a bacterial system reveal novel aspects of the evolutionary adaptation of phytochromes. © 2018, Gourinchas et al.

Major Geomagnetic Storms in Solar Cycle 24

NASA Astrophysics Data System (ADS)

Zheng, Y.

2013-12-01

Solar Cycle 24 has produced 11 major geomagnetic storms (where Dstmin < -100 nT) with three in 2011, six in 2012 and two in 2013 (as of 7 August 2013). Detailed analysis of each event will be given in terms of its solar driver(s): CME, coronal hole high speed solar wind stream (HSS), multiple CMEs or interactions between CME and HSS. While some of these storms are associated with a fast and wide CME, the few cases involving slow or common CMEs and interactions with HSS are particularly interesting. These events pose great challenges for accurate space weather forecasting, since operationally the slower or average CMEs tend to receive less attention and are sometimes overlooked altogether. The characteristics of such challenging, not-so-fast yet geoeffective CME events (such as their coronal signatures and interactions with surrounding solar wind structure(s), etc) will be examined in detail, with the goal of extracting common and telltale features, if any, of these CMEs that distinguish them from CMEs in a similar category.

A Comparative Study of Human Saposins.

PubMed

Garrido-Arandia, María; Cuevas-Zuviría, Bruno; Díaz-Perales, Araceli; Pacios, Luis F

2018-02-14

Saposins are small proteins implicated in trafficking and loading of lipids onto Cluster of Differentiation 1 (CD1) receptor proteins that in turn present lipid antigens to T cells and a variety of T-cell receptors, thus playing a crucial role in innate and adaptive immune responses in humans. Despite their low sequence identity, the four types of human saposins share a similar folding pattern consisting of four helices linked by three conserved disulfide bridges. However, their lipid-binding abilities as well as their activities in extracting, transporting and loading onto CD1 molecules a variety of sphingo- and phospholipids in biological membranes display two striking characteristics: a strong pH-dependence and a structural change between a compact, closed conformation and an open conformation. In this work, we present a comparative computational study of structural, electrostatic, and dynamic features of human saposins based upon their available experimental structures. By means of structural alignments, surface analyses, calculation of pH-dependent protonation states, Poisson-Boltzmann electrostatic potentials, and molecular dynamics simulations at three pH values representative of biological media where saposins fulfill their function, our results shed light into their intrinsic features. The similarities and differences in this class of proteins depend on tiny variations of local structural details that allow saposins to be key players in triggering responses in the human immune system.

Extraction of sandy bedforms features through geodesic morphometry

NASA Astrophysics Data System (ADS)

Debese, Nathalie; Jacq, Jean-José; Garlan, Thierry

2016-09-01

State-of-art echosounders reveal fine-scale details of mobile sandy bedforms, which are commonly found on continental shelfs. At present, their dynamics are still far from being completely understood. These bedforms are a serious threat to navigation security, anthropic structures and activities, placing emphasis on research breakthroughs. Bedform geometries and their dynamics are closely linked; therefore, one approach is to develop semi-automatic tools aiming at extracting their structural features from bathymetric datasets. Current approaches mimic manual processes or rely on morphological simplification of bedforms. The 1D and 2D approaches cannot address the wide ranges of both types and complexities of bedforms. In contrast, this work attempts to follow a 3D global semi-automatic approach based on a bathymetric TIN. The currently extracted primitives are the salient ridge and valley lines of the sand structures, i.e., waves and mega-ripples. The main difficulty is eliminating the ripples that are found to heavily overprint any observations. To this end, an anisotropic filter that is able to discard these structures while still enhancing the wave ridges is proposed. The second part of the work addresses the semi-automatic interactive extraction and 3D augmented display of the main lines structures. The proposed protocol also allows geoscientists to interactively insert topological constraints.

Computational and Statistical Analyses of Amino Acid Usage and Physico-Chemical Properties of the Twelve Late Embryogenesis Abundant Protein Classes

PubMed Central

Jaspard, Emmanuel; Macherel, David; Hunault, Gilles

2012-01-01

Late Embryogenesis Abundant Proteins (LEAPs) are ubiquitous proteins expected to play major roles in desiccation tolerance. Little is known about their structure - function relationships because of the scarcity of 3-D structures for LEAPs. The previous building of LEAPdb, a database dedicated to LEAPs from plants and other organisms, led to the classification of 710 LEAPs into 12 non-overlapping classes with distinct properties. Using this resource, numerous physico-chemical properties of LEAPs and amino acid usage by LEAPs have been computed and statistically analyzed, revealing distinctive features for each class. This unprecedented analysis allowed a rigorous characterization of the 12 LEAP classes, which differed also in multiple structural and physico-chemical features. Although most LEAPs can be predicted as intrinsically disordered proteins, the analysis indicates that LEAP class 7 (PF03168) and probably LEAP class 11 (PF04927) are natively folded proteins. This study thus provides a detailed description of the structural properties of this protein family opening the path toward further LEAP structure - function analysis. Finally, since each LEAP class can be clearly characterized by a unique set of physico-chemical properties, this will allow development of software to predict proteins as LEAPs. PMID:22615859

Three-dimensional biofilm structure quantification.

PubMed

Beyenal, Haluk; Donovan, Conrad; Lewandowski, Zbigniew; Harkin, Gary

2004-12-01

Quantitative parameters describing biofilm physical structure have been extracted from three-dimensional confocal laser scanning microscopy images and used to compare biofilm structures, monitor biofilm development, and quantify environmental factors affecting biofilm structure. Researchers have previously used biovolume, volume to surface ratio, roughness coefficient, and mean and maximum thicknesses to compare biofilm structures. The selection of these parameters is dependent on the availability of software to perform calculations. We believe it is necessary to develop more comprehensive parameters to describe heterogeneous biofilm morphology in three dimensions. This research presents parameters describing three-dimensional biofilm heterogeneity, size, and morphology of biomass calculated from confocal laser scanning microscopy images. This study extends previous work which extracted quantitative parameters regarding morphological features from two-dimensional biofilm images to three-dimensional biofilm images. We describe two types of parameters: (1) textural parameters showing microscale heterogeneity of biofilms and (2) volumetric parameters describing size and morphology of biomass. The three-dimensional features presented are average (ADD) and maximum diffusion distances (MDD), fractal dimension, average run lengths (in X, Y and Z directions), aspect ratio, textural entropy, energy and homogeneity. We discuss the meaning of each parameter and present the calculations in detail. The developed algorithms, including automatic thresholding, are implemented in software as MATLAB programs which will be available at site prior to publication of the paper.

Fine structural features of nanoscale zero-valent iron characterized by spherical aberration corrected scanning transmission electron microscopy (Cs-STEM).

PubMed

Liu, Airong; Zhang, Wei-xian

2014-09-21

An angstrom-resolution physical model of nanoscale zero-valent iron (nZVI) is generated with a combination of spherical aberration corrected scanning transmission electron microscopy (Cs-STEM), selected area electron diffraction (SAED), energy-dispersive X-ray spectroscopy (EDS) and electron energy-loss spectroscopy (EELS) on the Fe L-edge. Bright-field (BF), high-angle annular dark-field (HAADF) and secondary electron (SE) imaging of nZVI acquired by a Hitachi HD-2700 STEM show near atomic resolution images and detailed morphological and structural information of nZVI. The STEM-EDS technique confirms that the fresh nZVI comprises of a metallic iron core encapsulated with a thin layer of iron oxides or oxyhydroxides. SAED patterns of the Fe core suggest the polycrystalline structure in the metallic core and amorphous nature of the oxide layer. Furthermore, Fe L-edge of EELS shows varied structural features from the innermost Fe core to the outer oxide shell. A qualitative analysis of the Fe L(2,3) edge fine structures reveals that the shell of nZVI consists of a mixed Fe(II)/Fe(III) phase close to the Fe (0) interface and a predominantly Fe(III) at the outer surface of nZVI.

Imaging the internal structure of fluid upflow zones with detailed digital Parasound echosounder surveys

NASA Astrophysics Data System (ADS)

Spiess, V.; Zuehlsdorff, L.; von Lom-Keil, H.; Schwenk, T.

2001-12-01

Sites of venting fluids both with continuous and episodic supply often reveal complex surface and internal structures, which are difficult to image and cause problems to transfer results from local sampling towards a structural reconstruction and a quantification of (average) flux rates. Detailed acoustic and seismic surveys would be required to retrieve this information, but also an appropriate environment, where fluid migration can be properly imaged from contrasts to unaffected areas. Hemipelagic sediments are most suitable, since typically reflectors are coherent and of low lateral amplitude variation and structures are continuous over distances much longer than the scale of fluid migration features. During RV Meteor Cruise M473 and RV Sonne Cruise SO 149 detailed studies were carried out in the vicinity of potential fluid upflow zones in the Lower Congo Basin at 5oS in 3000 m water depth and at the Northern Cascadia Margin in 1000 m water depth. Unexpected sampling of massive gas hydrates from the sea floor as well as of carbonate concretions, shell fragments and different liveforms indicated active fluid venting in a typically hemipelagic realm. The acoustic signature of such zones includes columnar blanking, pockmark depressions at the sea floor, association with small offset faults (< 1m). A dedicated survey with closely spaced grid lines was carried out with the Parasound sediment echosounder (4 kHz), which data were digitally acquired with the ParaDigMA System for further processing and display, to image the spatial structure of the upflow zones. Due to the high data density amplitudes and other acoustic properties could be investigated in a 3D volume and time slices as well as reflector surfaces were analyzed. Pronounced lateral variations of reflection amplitudes within a complex pattern indicate potential pathways for fluid/gas migration and occurrences of near-surface gas hydrate deposits, which may be used to trace detailed surface evidence from side scan sonar imaging down to depth and support dedicated sampling.

Bayesian depth estimation from monocular natural images.

PubMed

Su, Che-Chun; Cormack, Lawrence K; Bovik, Alan C

2017-05-01

Estimating an accurate and naturalistic dense depth map from a single monocular photographic image is a difficult problem. Nevertheless, human observers have little difficulty understanding the depth structure implied by photographs. Two-dimensional (2D) images of the real-world environment contain significant statistical information regarding the three-dimensional (3D) structure of the world that the vision system likely exploits to compute perceived depth, monocularly as well as binocularly. Toward understanding how this might be accomplished, we propose a Bayesian model of monocular depth computation that recovers detailed 3D scene structures by extracting reliable, robust, depth-sensitive statistical features from single natural images. These features are derived using well-accepted univariate natural scene statistics (NSS) models and recent bivariate/correlation NSS models that describe the relationships between 2D photographic images and their associated depth maps. This is accomplished by building a dictionary of canonical local depth patterns from which NSS features are extracted as prior information. The dictionary is used to create a multivariate Gaussian mixture (MGM) likelihood model that associates local image features with depth patterns. A simple Bayesian predictor is then used to form spatial depth estimates. The depth results produced by the model, despite its simplicity, correlate well with ground-truth depths measured by a current-generation terrestrial light detection and ranging (LIDAR) scanner. Such a strong form of statistical depth information could be used by the visual system when creating overall estimated depth maps incorporating stereopsis, accommodation, and other conditions. Indeed, even in isolation, the Bayesian predictor delivers depth estimates that are competitive with state-of-the-art "computer vision" methods that utilize highly engineered image features and sophisticated machine learning algorithms.

Breast tissue classification in digital tomosynthesis images based on global gradient minimization and texture features

NASA Astrophysics Data System (ADS)

Qin, Xulei; Lu, Guolan; Sechopoulos, Ioannis; Fei, Baowei

2014-03-01

Digital breast tomosynthesis (DBT) is a pseudo-three-dimensional x-ray imaging modality proposed to decrease the effect of tissue superposition present in mammography, potentially resulting in an increase in clinical performance for the detection and diagnosis of breast cancer. Tissue classification in DBT images can be useful in risk assessment, computer-aided detection and radiation dosimetry, among other aspects. However, classifying breast tissue in DBT is a challenging problem because DBT images include complicated structures, image noise, and out-of-plane artifacts due to limited angular tomographic sampling. In this project, we propose an automatic method to classify fatty and glandular tissue in DBT images. First, the DBT images are pre-processed to enhance the tissue structures and to decrease image noise and artifacts. Second, a global smooth filter based on L0 gradient minimization is applied to eliminate detailed structures and enhance large-scale ones. Third, the similar structure regions are extracted and labeled by fuzzy C-means (FCM) classification. At the same time, the texture features are also calculated. Finally, each region is classified into different tissue types based on both intensity and texture features. The proposed method is validated using five patient DBT images using manual segmentation as the gold standard. The Dice scores and the confusion matrix are utilized to evaluate the classified results. The evaluation results demonstrated the feasibility of the proposed method for classifying breast glandular and fat tissue on DBT images.

Parametric representation of weld fillets using shell finite elements—a proposal based on minimum stiffness and inertia errors

NASA Astrophysics Data System (ADS)

Echer, L.; Marczak, R. J.

2018-02-01

The objective of the present work is to introduce a methodology capable of modelling welded components for structural stress analysis. The modelling technique was based on the recommendations of the International Institute of Welding; however, some geometrical features of the weld fillet were used as design parameters in an optimization problem. Namely, the weld leg length and thickness of the shell elements representing the weld fillet were optimized in such a way that the first natural frequencies were not changed significantly when compared to a reference result. Sequential linear programming was performed for T-joint structures corresponding to two different structural details: with and without full penetration weld fillets. Both structural details were tested in scenarios of various plate thicknesses and depths. Once the optimal parameters were found, a modelling procedure was proposed for T-shaped components. Furthermore, the proposed modelling technique was extended for overlapped welded joints. The results obtained were compared to well-established methodologies presented in standards and in the literature. The comparisons included results for natural frequencies, total mass and structural stress. By these comparisons, it was observed that some established practices produce significant errors in the overall stiffness and inertia. The methodology proposed herein does not share this issue and can be easily extended to other types of structure.

The Use of the STAGS Finite Element Code in Stitched Structures Development

NASA Technical Reports Server (NTRS)

Jegley, Dawn C.; Lovejoy, Andrew E.

2014-01-01

In the last 30 years NASA has worked in collaboration with industry to develop enabling technologies needed to make aircraft more fuel-efficient and more affordable. The focus on the airframe has been to reduce weight, improve damage tolerance and better understand structural behavior under realistic flight and ground loading conditions. Stitched structure is a technology that can address the weight savings, cost reduction, and damage tolerance goals, but only if it is supported by accurate analytical techniques. Development of stitched technology began in the 1990's as a partnership between NASA and Boeing (McDonnell Douglas at the time) under the Advanced Composites Technology Program and has continued under various titles and programs and into the Environmentally Responsible Aviation Project today. These programs contained development efforts involving manufacturing development, design, detailed analysis, and testing. Each phase of development, from coupons to large aircraft components was supported by detailed analysis to prove that the behavior of these structures was well-understood and predictable. The Structural Analysis of General Shells (STAGS) computer code was a critical tool used in the development of many stitched structures. As a key developer of STAGS, Charles Rankin's contribution to the programs was quite significant. Key features of STAGS used in these analyses and discussed in this paper include its accurate nonlinear and post-buckling capabilities, its ability to predict damage growth, and the use of Lagrange constraints and follower forces.

Structural Architecture of Prothrombin in Solution Revealed by Single Molecule Spectroscopy.

PubMed

Pozzi, Nicola; Bystranowska, Dominika; Zuo, Xiaobing; Di Cera, Enrico

2016-08-26

The coagulation factor prothrombin has a complex spatial organization of its modular assembly that comprises the N-terminal Gla domain, kringle-1, kringle-2, and the C-terminal protease domain connected by three intervening linkers. Here we use single molecule Förster resonance energy transfer to access the conformational landscape of prothrombin in solution and uncover structural features of functional significance that extend recent x-ray crystallographic analysis. Prothrombin exists in equilibrium between two alternative conformations, open and closed. The closed conformation predominates (70%) and features an unanticipated intramolecular collapse of Tyr(93) in kringle-1 onto Trp(547) in the protease domain that obliterates access to the active site and protects the zymogen from autoproteolytic conversion to thrombin. The open conformation (30%) is more susceptible to chymotrypsin digestion and autoactivation, and features a shape consistent with recent x-ray crystal structures. Small angle x-ray scattering measurements of prothrombin wild type stabilized 70% in the closed conformation and of the mutant Y93A stabilized 80% in the open conformation directly document two envelopes that differ 50 Å in length. These findings reveal important new details on the conformational plasticity of prothrombin in solution and the drastic structural difference between its alternative conformations. Prothrombin uses the intramolecular collapse of kringle-1 onto the active site in the closed form to prevent autoactivation. The open-closed equilibrium also defines a new structural framework for the mechanism of activation of prothrombin by prothrombinase. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Software model of a machine vision system based on the common house fly.

PubMed

Madsen, Robert; Barrett, Steven; Wilcox, Michael

2005-01-01

The vision system of the common house fly has many properties, such as hyperacuity and parallel structure, which would be advantageous in a machine vision system. A software model has been developed which is ultimately intended to be a tool to guide the design of an analog real time vision system. The model starts by laying out cartridges over an image. The cartridges are analogous to the ommatidium of the fly's eye and contain seven photoreceptors each with a Gaussian profile. The spacing between photoreceptors is variable providing for more or less detail as needed. The cartridges provide information on what type of features they see and neighboring cartridges share information to construct a feature map.

Piceance Creek Basin, Colorado, Oil Shale Geodatabase

USGS Publications Warehouse

,

2006-01-01

This geodatabase is a digital reproduction of three legacy USGS oil shale publications--MF-958 (Pitman and Johnson, 1978), MF-1069 (Pitman, 1979), and OC-132 (Pitman and others, 1990). The database consists of 106 feature classes in three feature datasets organized by publication. Each dataset contains isopach contours, isoresource contours, isoresource polygons, and corehole and drillhole locations with resource values for 12 kerogen-rich (R) and kerogen-lean (L) oil shale zones in the Piceance Creek Basin, Colorado. The uppermost zones, Mahogany and R-6, also contain detailed structure files. The zones in descending order are: Mahogany, R-6, L-5, R-5, L-4, R-4, L-3, R-3, L-2, R-2, L-1, and R-1.

Photogrammetric 3d Reconstruction in Matlab: Development of a Free Tool

NASA Astrophysics Data System (ADS)

Masiero, A.

2017-11-01

This paper presents the current state of development of a free Matlab tool for photogrammetric reconstruction developed at the University of Padova, Italy. The goal of this software is mostly educational, i.e. allowing students to have a close look to the specific steps which lead to the computation of a dense point cloud. As most of recently developed photogrammetric softwares, it is based on a Structure from Motion approach. Despite being mainly motivated by educational purposes, certain implementation details are clearly inspired by recent research works, e.g. limiting the computational burden of the feature matching by determining a suboptimal set of features to be considered, using information provided by external sensors to ease the matching process.

Recent Advances in Characterization of Lignin Polymer by Solution-State Nuclear Magnetic Resonance (NMR) Methodology

PubMed Central

Wen, Jia-Long; Sun, Shao-Long; Xue, Bai-Liang; Sun, Run-Cang

2013-01-01

The demand for efficient utilization of biomass induces a detailed analysis of the fundamental chemical structures of biomass, especially the complex structures of lignin polymers, which have long been recognized for their negative impact on biorefinery. Traditionally, it has been attempted to reveal the complicated and heterogeneous structure of lignin by a series of chemical analyses, such as thioacidolysis (TA), nitrobenzene oxidation (NBO), and derivatization followed by reductive cleavage (DFRC). Recent advances in nuclear magnetic resonance (NMR) technology undoubtedly have made solution-state NMR become the most widely used technique in structural characterization of lignin due to its versatility in illustrating structural features and structural transformations of lignin polymers. As one of the most promising diagnostic tools, NMR provides unambiguous evidence for specific structures as well as quantitative structural information. The recent advances in two-dimensional solution-state NMR techniques for structural analysis of lignin in isolated and whole cell wall states (in situ), as well as their applications are reviewed. PMID:28809313

Exercises in anatomy: the normal heart.

PubMed

Anderson, Robert H; Sarwark, Anne; Spicer, Diane E; Backer, Carl L

2014-01-01

In this series of videoclips, we analyze the anatomy of the normal heart. We begin our overview by emphasizing the need, in the current era, to describe the heart in attitudinally appropriate fashion. Increasingly, clinicians are demonstrating the features of the heart as it is located within the body. It is no longer satisfactory, therefore, to describe these components in a ‘Valentine’ fashion, as continues to be the case in most textbooks of normal or cardiac anatomy. We then emphasize the importance of the so-called morphological method, which states that structures within the heart should be defined on the basis of their own intrinsic morphology, and not according to other parts, which are themselves variable. We continue by using this concept to show how the appendages serve to distinguish between the atrial chambers, while the apical trabecular components provide the features to distinguish the ventricles. We then return to the cardiac chambers, emphasizing features of surgical significance, in particular the locations of the cardiac conduction tissues. We proceed by examining the cardiac valves, and conclude by providing a detailed analysis of the septal structures. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Development and evaluation of a new taxonomy of mobility-related assistive technology devices.

PubMed

Shoemaker, Laura L; Lenker, James A; Fuhrer, Marcus J; Jutai, Jeffrey W; Demers, Louise; DeRuyter, Frank

2010-10-01

This article reports on the development of a new taxonomy for mobility-related assistive technology devices. A prototype taxonomy was created based on the extant literature. Five mobility device experts were engaged in a modified Delphi process to evaluate and refine the taxonomy. Multiple iterations of expert feedback and revision yielded consensual agreement on the structure and terminology of a new mobility device taxonomy. The taxonomy uses a hierarchical framework to classify ambulation aids and wheeled mobility devices, including their key features that impact mobility. Five attributes of the new taxonomy differentiate it from previous mobility-related device classifications: (1) hierarchical structure, (2) primary device categories are grouped based on their intended mobility impact, (3) comprehensive inclusion of technical features, (4) a capacity to assimilate reimbursement codes, and (5) availability of a detailed glossary. The taxonomy is intended to support assistive technology outcomes research. The taxonomy will enable researchers to capture mobility-related assistive technology device interventions with precision and provide a common terminology that will allow comparisons among studies. The prominence of technical features within the new taxonomy will hopefully promote research that helps clinicians predict how devices will perform, thus aiding clinical decision making and supporting funding recommendations.

Line structures in the X-ray spectra of Cygnus X-2 observed with Exosat

NASA Technical Reports Server (NTRS)

Freeman, P. E.; Kahn, S. M.; Chiappetti, L.; Tanzi, E. G.; Ciapi, A.; Maraschi, L.; Treves, A.; Branduardi-Raymont, E. G.; Ercan, E. N.

1990-01-01

Cygnus X-2 was observed with Exosat at five phases of a single orbital cycle in September of 1983. The results of spectral fits of the LE + ME (Argon) data are summarized in terms of a superposition of thermal bremsstrahlung and blackbody components. During the first observation, a grating spectrum was obtained, and this is described in some detail. The GSPC data are used to investigate the presence of iron features and their behavior during dips.

Telerobotics test bed for space structure assembly

NASA Technical Reports Server (NTRS)

Kitami, M.; Ogimoto, K.; Yasumoto, F.; Katsuragawa, T.; Itoko, T.; Kurosaki, Y.; Hirai, S.; Machida, K.

1994-01-01

A cooperative research on super long distance space telerobotics is now in progress both in Japan and USA. In this program. several key features will be tested, which can be applicable to the control of space robots as well as to terrestrial robots. Local (control) and remote (work) sites will be shared between Electrotechnical Lab (ETL) of MITI in Japan and Jet Propulsion Lab (JPL) in USA. The details of a test bed for this international program are discussed in this report.

Perovskites: transforming photovoltaics, a mini-review

DOE PAGES

Chilvery, Ashwith Kumar; Batra, Ashok K.; Yang, Bin; ...

2015-01-06

The recent power-packed advent of perovskite solar cells is transforming photovoltaics (PV) with their superior efficiencies, ease of fabrication, and cost. This perovskite solar cell further boasts of many unexplored features that can further enhance its PV properties and lead to it being branded as a successful commercial product. This paper provides a detailed insight of the organometal halide based perovskite structure, its unique stoichiometric design, and its underlying principles for PV applications. Finally, the compatibility of various PV layers and its fabrication methods is also discussed.

Note: Rigid holder to host and bend a crystal for multiple volume reflection of a particle beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carassiti, V.; Melchiorri, M.; Dalpiaz, P.

2010-06-15

A holder to lodge and bend a silicon crystal to excite multivolume reflection of a high-energy particle beam has been designed and fabricated. A mechanically robust and stable structure fastens a crystal at best condition for experiments. The holder has allowed the observation of 12-time repeated volume reflection with very high efficiency. We detail the most important features behind the construction of the holder together with the characterization of the crystal being bent by the holder.

Cryogenic testing of Planck sorption cooler test facility

NASA Technical Reports Server (NTRS)

Zhang, B.; Pearson, D.; Borders, J.; Franklin, B.; Prina, M.; Hardy, J.; Crumb, D.

2004-01-01

A test facility has been upgraded in preparation for testing of two hydrogen sorption cryocoolers operating at 18/20 K. these sorption coolers are currently under development at the Jet Propulsion Laboratory. This work summarizes the scope of the test facility upgrade, including design for cryogenic cooling power delivery, system thermal management, insulation schemes, and data acquisition techniques. Ground support equipment for the sorption coolers, structural features of the test chamber, and the vacuum system involved for system testing will also be described in detail.

Synthetic and semi-synthetic chondroitin sulfate oligosaccharides, polysaccharides, and glycomimetics.

PubMed

Bedini, Emiliano; Parrilli, Michelangelo

2012-07-15

Chondroitin sulfate (CS) is a sulfated polysaccharide involved in a myriad of biological processes. Due to the variable sulfation pattern of CS polymer chains, the need to study in detail structure-activity relationships regarding CS biomedical features has provoked much interest in obtaining synthetic CS species. This paper reviews two decades of synthetic and semi-synthetic CS oligosaccharides, polysaccharides, and glycomimetics obtained by chemical, chemoenzymatic, enzymatic, and microbiological-chemical strategies. Copyright © 2012 Elsevier Ltd. All rights reserved.

Global features of the semiannual oscillation in stratospheric temperatures and comparison between seasons and hemispheres

NASA Technical Reports Server (NTRS)

Gao, Xin-Hai; Yu, Wen-Bi; Stanford, John L.

1987-01-01

Four years of satellite-derived microwave and infrared radiances are analyzed for the three-dimensional and seasonal variation of semiannual oscillations (SAO) in stratospheric temperatures, with particular focus on high latitudes, to investigate the effect of stratospheric warmings on SAO. Separate analyses of individual seasons in each hemisphere reveal that the strongest SAO in temperature occur in the Northern Hemisphere (NH) winter polar upper stratosphere. These results, together with the latitudinal structure of the temperature SAO and the fact that the NH polar SAO is nearly out of phase with the lower latitude SAO, are consistent with the existence of a global-scale, meridional circulation on the SAO time scale. The results suggest that polar stratospheric warmings are an important source of SAO in both high and low latitude stratospheric temperature fields. Interannual variations, three-dimensional phase structure, and zonal asymmetry of SAO are also detailed. The SH stratospheric SAO is dominated by a localized feature in the high-latitude, eastern hemisphere which tilts westward with height.

Interstellar polycyclic aromatic hydrocarbons - The infrared emission bands, the excitation/emission mechanism, and the astrophysical implications

NASA Technical Reports Server (NTRS)

Allamandola, L. J.; Tielens, G. G. M.; Barker, J. R.

1989-01-01

A comprehensive study of the PAH hypothesis is presented, including the interstellar, IR spectral features which have been attributed to emission from highly vibrationally excited PAHs. Spectroscopic and IR emission features are discussed in detail. A method for calculating the IR fluorescence spectrum from a vibrationally excited molecule is described. Analysis of interstellar spectrum suggests that the PAHs which dominate the IR spectra contain between 20 and 40 C atoms. The results are compared with results from a thermal approximation. It is found that, for high levels of vibrational excitation and emission from low-frequency modes, the two methods produce similar results. Also, consideration is given to the relationship between PAH molecules and amorphous C particles, the most likely interstellar PAH molecular structures, the spectroscopic structure produced by PAHs and PAH-related materials in the UV portion of the interstellar extinction curve, and the influence of PAH charge on the UV, visible, and IR regions.

HST imaging of quasi-stellar objects with WFPC2

NASA Technical Reports Server (NTRS)

Hutchings, J. B.; Holtzman, Jon; Sparks, W. B.; Morris, S. C.; Hanisch, R. J.; Mo, J.

1994-01-01

Early images were taken with the optically corrected WFPC2 camera of the Hubble Space Telescope of the low-redshift quasars(QSOs) 1229+204 and 2141+175, which are radio-quiet and radio-loud, respectively. We discuss image restoration on the data. The objects were chosen on the basis of structure seen with 0.5 sec resolution with the Canada-France-Hawaii-Telescope (CFHT) high-resolution camera (HRCAM). 1229+204 was known to be a barred spiral with an asymmetrical extra blue feature: this is now resolved into a ring of knots which are probably young stellar populations in the tidal debris of a small gas-rich companion. There are also shell-like structures along the bar. 2141+175 has a faint smooth curved tidal arm without knots which extends on both sides of a compact elliptical-shaped central galaxy. There is also a short jetlike feature emerging from the nucleus. We discuss the properties and implications of these morphological details.

A study of the comparative anatomy of the brain of domestic ruminants using magnetic resonance imaging.

PubMed

Schmidt, M J; Langen, N; Klumpp, S; Nasirimanesh, F; Shirvanchi, P; Ondreka, N; Kramer, M

2012-01-01

Although magnetic resonance imaging has been used to examine the brain of domestic ruminants, detailed information relating the precise anatomical features in these species is lacking. In this study the brain structures of calves (Bos taurus domesticus), sheep (Ovis aries), goats (Capra hircus) and a mesaticephalic dog (Canis lupis familiaris) were examined using T2-weighed Turbo Spin Echo sequences; three-dimensional models based on high-resolution gradient echo scans were used to identify brain sulci and gyri in two-dimensional images. The ruminant brains examined were similar in structure and organisation to those of other mammals but particular features included the deep depression of the insula and the pronounced gyri of the cortices, the dominant position of the visual (optic nerve, optic chiasm and rostral colliculus) and olfactory (olfactory bulb, olfactory tracts and piriform lobe) systems, and the relatively large size of the diencephalon. Copyright © 2010 Elsevier Ltd. All rights reserved.

Astragalar Morphology of Selected Giraffidae

PubMed Central

2016-01-01

The artiodactyl astragalus has been modified to exhibit two trochleae, creating a double pullied structure allowing for significant dorso-plantar motion, and limited mediolateral motion. The astragalus structure is partly influenced by environmental substrates, and correspondingly, morphometric studies can yield paleohabitat information. The present study establishes terminology and describes detailed morphological features on giraffid astragali. Each giraffid astragalus exhibits a unique combination of anatomical characteristics. The giraffid astragalar morphologies reinforce previously established phylogenetic relationships. We find that the enlargement of the navicular head is a feature shared by all giraffids, and that the primitive giraffids possess exceptionally tall astragalar heads in relation to the total astragalar height. The sivatheres and the okapi share a reduced notch on the lateral edge of the astragalus. We find that Samotherium is more primitive in astragalar morphologies than Palaeotragus, which is reinforced by tooth characteristics and ossicone position. Diagnostic anatomical characters on the astragalus allow for giraffid species identifications and a better understanding of Giraffidae. PMID:27028515

Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.

PubMed

Qian, Kevin; Wang, Lian; Cywin, Charles L; Farmer, Bennett T; Hickey, Eugene; Homon, Carol; Jakes, Scott; Kashem, Mohammed A; Lee, George; Leonard, Scott; Li, Jun; Magboo, Ronald; Mao, Wang; Pack, Edward; Peng, Charlene; Prokopowicz, Anthony; Welzel, Morgan; Wolak, John; Morwick, Tina

2009-04-09

A series of inhibitors of Pim-2 kinase identified by high-throughput screening is described. Details of the hit validation and lead generation process and structure-activity relationship (SAR) studies are presented. Disclosure of an unconventional binding mode for 1, as revealed by X-ray crystallography using the highly homologous Pim-1 protein, is also presented, and observed binding features are shown to correlate with the Pim-2 SAR. While highly selective within the kinase family, the series shows similar potency for both Pim-1 and Pim-2, which was expected on the basis of homology, but unusual in light of reports in the literature documenting a bias for Pim-1. A rationale for these observations based on Pim-1 and Pim-2 K(M(ATP)) values is suggested. Some interesting cross reactivity with casein kinase-2 was also identified, and structural features which may contribute to the association are discussed.

Standardization of accelerator irradiation procedures for simulation of neutron induced damage in reactor structural materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shao, Lin; Gigax, Jonathan; Chen, Di

Self-ion irradiation is widely used as a method to simulate neutron damage in reactor structural materials. Accelerator-based simulation of void swelling, however, introduces a number of neutron-atypical features which require careful data extraction and in some cases introduction of innovative irradiation techniques to alleviate these issues. We briefly summarize three such atypical features: defect imbalance effects, pulsed beam effects, and carbon contamination. The latter issue has just been recently recognized as being relevant to simulation of void swelling and is discussed here in greater detail. It is shown that carbon ions are entrained in the ion beam by Coulomb forcemore » drag and accelerated toward the target surface. Beam-contaminant interactions are modeled using molecular dynamics simulation. By applying a multiple beam deflection technique, carbon and other contaminants can be effectively filtered out, as demonstrated in an irradiation of HT-9 alloy by 3.5 MeV Fe ions.« less

Standardization of accelerator irradiation procedures for simulation of neutron induced damage in reactor structural materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shao, Lin; Gigax, Jonathan; Chen, Di

Self-ion irradiation is widely used as a method to simulate neutron damage in reactor structural materials. Accelerator-based simulation of void swelling, however, introduces a number of neutron-atypical features which require careful data extraction and, in some cases, introduction of innovative irradiation techniques to alleviate these issues. In this paper, we briefly summarize three such atypical features: defect imbalance effects, pulsed beam effects, and carbon contamination. The latter issue has just been recently recognized as being relevant to simulation of void swelling and is discussed here in greater detail. It is shown that carbon ions are entrained in the ion beammore » by Coulomb force drag and accelerated toward the target surface. Beam-contaminant interactions are modeled using molecular dynamics simulation. Finally, by applying a multiple beam deflection technique, carbon and other contaminants can be effectively filtered out, as demonstrated in an irradiation of HT-9 alloy by 3.5 MeV Fe ions.« less

Standardization of accelerator irradiation procedures for simulation of neutron induced damage in reactor structural materials

DOE PAGES

Shao, Lin; Gigax, Jonathan; Chen, Di; ...

2017-06-12

Self-ion irradiation is widely used as a method to simulate neutron damage in reactor structural materials. Accelerator-based simulation of void swelling, however, introduces a number of neutron-atypical features which require careful data extraction and, in some cases, introduction of innovative irradiation techniques to alleviate these issues. In this paper, we briefly summarize three such atypical features: defect imbalance effects, pulsed beam effects, and carbon contamination. The latter issue has just been recently recognized as being relevant to simulation of void swelling and is discussed here in greater detail. It is shown that carbon ions are entrained in the ion beammore » by Coulomb force drag and accelerated toward the target surface. Beam-contaminant interactions are modeled using molecular dynamics simulation. Finally, by applying a multiple beam deflection technique, carbon and other contaminants can be effectively filtered out, as demonstrated in an irradiation of HT-9 alloy by 3.5 MeV Fe ions.« less

Evolving phenotypic networks in silico.

PubMed

François, Paul

2014-11-01

Evolved gene networks are constrained by natural selection. Their structures and functions are consequently far from being random, as exemplified by the multiple instances of parallel/convergent evolution. One can thus ask if features of actual gene networks can be recovered from evolutionary first principles. I review a method for in silico evolution of small models of gene networks aiming at performing predefined biological functions. I summarize the current implementation of the algorithm, insisting on the construction of a proper "fitness" function. I illustrate the approach on three examples: biochemical adaptation, ligand discrimination and vertebrate segmentation (somitogenesis). While the structure of the evolved networks is variable, dynamics of our evolved networks are usually constrained and present many similar features to actual gene networks, including properties that were not explicitly selected for. In silico evolution can thus be used to predict biological behaviours without a detailed knowledge of the mapping between genotype and phenotype. Copyright © 2014 The Author. Published by Elsevier Ltd.. All rights reserved.

A comparative study of new and current methods for dental micro-CT image denoising

PubMed Central

Lashgari, Mojtaba; Qin, Jie; Swain, Michael

2016-01-01

Objectives: The aim of the current study was to evaluate the application of two advanced noise-reduction algorithms for dental micro-CT images and to implement a comparative analysis of the performance of new and current denoising algorithms. Methods: Denoising was performed using gaussian and median filters as the current filtering approaches and the block-matching and three-dimensional (BM3D) method and total variation method as the proposed new filtering techniques. The performance of the denoising methods was evaluated quantitatively using contrast-to-noise ratio (CNR), edge preserving index (EPI) and blurring indexes, as well as qualitatively using the double-stimulus continuous quality scale procedure. Results: The BM3D method had the best performance with regard to preservation of fine textural features (CNREdge), non-blurring of the whole image (blurring index), the clinical visual score in images with very fine features and the overall visual score for all types of images. On the other hand, the total variation method provided the best results with regard to smoothing of images in texture-free areas (CNRTex-free) and in preserving the edges and borders of image features (EPI). Conclusions: The BM3D method is the most reliable technique for denoising dental micro-CT images with very fine textural details, such as shallow enamel lesions, in which the preservation of the texture and fine features is of the greatest importance. On the other hand, the total variation method is the technique of choice for denoising images without very fine textural details in which the clinician or researcher is interested mainly in anatomical features and structural measurements. PMID:26764583

Biocuration in the structure-function linkage database: the anatomy of a superfamily.

PubMed

Holliday, Gemma L; Brown, Shoshana D; Akiva, Eyal; Mischel, David; Hicks, Michael A; Morris, John H; Huang, Conrad C; Meng, Elaine C; Pegg, Scott C-H; Ferrin, Thomas E; Babbitt, Patricia C

2017-01-01

With ever-increasing amounts of sequence data available in both the primary literature and sequence repositories, there is a bottleneck in annotating molecular function to a sequence. This article describes the biocuration process and methods used in the structure-function linkage database (SFLD) to help address some of the challenges. We discuss how the hierarchy within the SFLD allows us to infer detailed functional properties for functionally diverse enzyme superfamilies in which all members are homologous, conserve an aspect of their chemical function and have associated conserved structural features that enable the chemistry. Also presented is the Enzyme Structure-Function Ontology (ESFO), which has been designed to capture the relationships between enzyme sequence, structure and function that underlie the SFLD and is used to guide the biocuration processes within the SFLD. http://sfld.rbvi.ucsf.edu/. © The Author 2017. Published by Oxford University Press.

Feasibility study tool for semi-rigid joints design of high-rise buildings steel structures

NASA Astrophysics Data System (ADS)

Bagautdinov, Ruslan; Monastireva, Daria; Bodak, Irina; Potapova, Irina

2018-03-01

There are many ways to consider the final cost of the high-rise building structures and to define, which of their different variations are the most effective from different points of view. The research of Jaakko Haapio is conducted in Tampere University of Technology, which aims to develop a method that allows determining the manufacturing and installation costs of steel structures already at the tender phase while taking into account their details. This paper is aimed to make the analysis of the Feature-Based Costing Method for skeletal steel structures proposed by Jaakko Haapio. The most appropriate ways to improve the tool and to implement it in the Russian circumstances for high-rise building design are derived. Presented tool can be useful not only for the designers but, also, for the steel structures manufacturing organizations, which can help to utilize BIM technologies in the organization process and controlling on the factory.

PDB@: an offline toolkit for exploration and analysis of PDB files.

PubMed

Mani, Udayakumar; Ravisankar, Sadhana; Ramakrishnan, Sai Mukund

2013-12-01

Protein Data Bank (PDB) is a freely accessible archive of the 3-D structural data of biological molecules. Structure based studies offers a unique vantage point in inferring the properties of a protein molecule from structural data. This is too big a task to be done manually. Moreover, there is no single tool, software or server that comprehensively analyses all structure-based properties. The objective of the present work is to develop an offline computational toolkit, PDB@ containing in-built algorithms that help categorizing the structural properties of a protein molecule. The user has the facility to view and edit the PDB file to his need. Some features of the present work are unique in itself and others are an improvement over existing tools. Also, the representation of protein properties in both graphical and textual formats helps in predicting all the necessary details of a protein molecule on a single platform.

Study of nanoscale structural biology using advanced particle beam microscopy

NASA Astrophysics Data System (ADS)

Boseman, Adam J.

This work investigates developmental and structural biology at the nanoscale using current advancements in particle beam microscopy. Typically the examination of micro- and nanoscale features is performed using scanning electron microscopy (SEM), but in order to decrease surface charging, and increase resolution, an obscuring conductive layer is applied to the sample surface. As magnification increases, this layer begins to limit the ability to identify nanoscale surface structures. A new technology, Helium Ion Microscopy (HIM), is used to examine uncoated surface structures on the cuticle of wild type and mutant fruit flies. Corneal nanostructures observed with HIM are further investigated by FIB/SEM to provide detailed three dimensional information about internal events occurring during early structural development. These techniques are also used to reconstruct a mosquito germarium in order to characterize unknown events in early oogenesis. Findings from these studies, and many more like them, will soon unravel many of the mysteries surrounding the world of developmental biology.

Structural Characterization of the Low-Molecular-Weight Heparin Dalteparin by Combining Different Analytical Strategies.

PubMed

Bisio, Antonella; Urso, Elena; Guerrini, Marco; de Wit, Pauline; Torri, Giangiacomo; Naggi, Annamaria

2017-06-24

A number of low molecular weight heparin (LMWH) products are available for clinical use and although all share a similar mechanism of action, they are classified as distinct drugs because of the different depolymerisation processes of the native heparin resulting in substantial pharmacokinetic and pharmacodynamics differences. While enoxaparin has been extensively investigated, little information is available regarding the LMWH dalteparin. The present study is focused on the detailed structural characterization of Fragmin ® by LC-MS and NMR applied both to the whole drug and to its enzymatic products. For a more in-depth approach, size homogeneous octasaccharide and decasaccharide components together with their fractions endowed with high or no affinity toward antithrombin were also isolated and their structural profiles characterized. The combination of different analytical strategies here described represents a useful tool for the assessment of batch-to-batch structural variability and for comparative evaluation of structural features of biosimilar products.

The possible importance of synchrotron/inverse Compton losses to explain fast MM-wave and hard X-ray emission of a solar event

NASA Technical Reports Server (NTRS)

Correia, E.; Kaufmann, P.; Costa, J. E. R.; Vaz, A. M. Z.; Dennis, B. R.

1986-01-01

The solar burst of 21 May 1984 presented a number of unique features. The time profile consisted of seven major structures (seconds), with a turnover frequency or approx. 90 GHz, well correlated in time to hard X-ray emission. Each structure consisted of multiple fast pulses (.1 seconds), which were analyzed in detail. A proportionality between the repetition rate of the pulses and the burst fluxes at 90 GHz and or approx. 100 keV hard X-rays, and an inverse proportionality between repetition rates and hard X-rays power law indices have been found. A synchrotron/inverse Compton model has been applied to explain the emission of the fast burst structures, which appear to be possible for the first three or four structures.

The possible importance of synchrotron/inverse Compton losses to explain fast mm-wave and hard X-ray emission of a solar event

NASA Technical Reports Server (NTRS)

Correia, E.; Kaufmann, P.; Costa, J. E. R.; Zodivaz, A. M.; Dennis, B. R.

1986-01-01

The solar burst of 21 May 1984, presented a number of unique features. The time profile consisted of seven major structures (seconds), with a turnover frequency of greater than or approximately 90 GHz, well correlated in time to hard X-ray emission. Each structure consisted of multiple fast pulses (0.1 seconds), which were analyzed in detail. A proportionality between the repetition rate of the pulses and the burst fluxes at 90 GHz and greater than or approximately 100 keV hard X-rays, and an inverse proportionality between repetition rates and hard X-ray power law indices were found. A synchrotron/inverse Compton model was applied to explain the emission of the fast burst structures, which appear to be possible for the first three or four structures.

Flynn Creek Impact Structure: New Insights from Breccias, Melt Features, Shatter Cones, and Remote Sensing

NASA Technical Reports Server (NTRS)

Evenick, J. C.; Lee, P.; Deane, B.

2004-01-01

The Flynn Creek impact structure is located in Tennessee, USA (36 deg.17 min.N, 85 deg.40 min.W). The structure was first mapped as a crypto-volcanic by Wilson and Born in 1936 [1]. Although they did not properly identify the stratigraphy within the crater or the causal mechanism, they did correctly define the horizontal extent of the crater. More detailed surface and subsurface research by Roddy (1979) accurately described the crater as being an impact structure with a diameter of 3.8 km. It formed around 360 Ma, which corresponds to the interval between the deposition of the Nashville Group and the Chattanooga Shale. Although there is limited rock outcrop in the area, there are exposed surface faults, folds, and large outcrops of impact breccia within the crater.

Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating

PubMed Central

Kim, Dorothy M.; Nimigean, Crina M.

2016-01-01

Voltage-gated potassium channels play a fundamental role in the generation and propagation of the action potential. The discovery of these channels began with predictions made by early pioneers, and has culminated in their extensive functional and structural characterization by electrophysiological, spectroscopic, and crystallographic studies. With the aid of a variety of crystal structures of these channels, a highly detailed picture emerges of how the voltage-sensing domain reports changes in the membrane electric field and couples this to conformational changes in the activation gate. In addition, high-resolution structural and functional studies of K+ channel pores, such as KcsA and MthK, offer a comprehensive picture on how selectivity is achieved in K+ channels. Here, we illustrate the remarkable features of voltage-gated potassium channels and explain the mechanisms used by these machines with experimental data. PMID:27141052

Integrated approach using data mining-based decision tree and object-based image analysis for high-resolution urban mapping of WorldView-2 satellite sensor data

NASA Astrophysics Data System (ADS)

Hamedianfar, Alireza; Shafri, Helmi Zulhaidi Mohd

2016-04-01

This paper integrates decision tree-based data mining (DM) and object-based image analysis (OBIA) to provide a transferable model for the detailed characterization of urban land-cover classes using WorldView-2 (WV-2) satellite images. Many articles have been published on OBIA in recent years based on DM for different applications. However, less attention has been paid to the generation of a transferable model for characterizing detailed urban land cover features. Three subsets of WV-2 images were used in this paper to generate transferable OBIA rule-sets. Many features were explored by using a DM algorithm, which created the classification rules as a decision tree (DT) structure from the first study area. The developed DT algorithm was applied to object-based classifications in the first study area. After this process, we validated the capability and transferability of the classification rules into second and third subsets. Detailed ground truth samples were collected to assess the classification results. The first, second, and third study areas achieved 88%, 85%, and 85% overall accuracies, respectively. Results from the investigation indicate that DM was an efficient method to provide the optimal and transferable classification rules for OBIA, which accelerates the rule-sets creation stage in the OBIA classification domain.

Featured Image: A Detailed Look at the Crab Nebula

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-07-01

Planning on watching fireworks tomorrow? Heres an astronomical firework to help you start the celebrations! A new study has stunningly detailed the Crab Nebula (click for a closer look), a nebula 6,500 light-years away thought to have been formedby a supernova explosion and the subsequent ultrarelativistic wind emitted by the pulsar at its heart. Led by Gloria Dubner (University of Buenos Aires), the authors of this study obtained new observations of the Crab Nebula from five different telescopes. They compiled these observations to compare the details of the nebulas structure across different wavelengths, which allowedthem to learnabout the sources of various features within the nebula. In the images above, thetop left shows the 3 GHz data from the Very Large Array (radio). Moving clockise, the radio data (shown in red) is composited with: infrared data from Spitzer Space Telescope, optical continuum from Hubble Space Telescope, 500-nm optical datafrom Hubble, and ultraviolet data from XMM-Newton. The final two images are of the nebula center, and they are composites of the radio imagewith X-ray data from Chandra and near-infrared data from Hubble. To read more about what Dubner and collaborators learned (and to see more spectacular images!), check out the paper below.CitationG. Dubner et al 2017 ApJ 840 82. doi:10.3847/1538-4357/aa6983

An in-depth understanding of biomass recalcitrance using natural poplar variants as the feedstock

DOE PAGES

Meng, Xianzhi; Pu, Yunqiao; Yoo, Chang Geun; ...

2016-12-12

Here, in an effort to better understand the biomass recalcitrance, six natural poplar variants were selected as feedstocks based on previous sugar release analysis. Compositional analysis and physicochemical characterizations of these poplars were performed and the correlations between these physicochemical properties and enzymatic hydrolysis yield were investigated. Gel permeation chromatography (GPC) and 13C solid state NMR were used to determine the degree of polymerization (DP) and crystallinity index (CrI) of cellulose, and the results along with the sugar release study indicated that cellulose DP likely played a more important role in enzymatic hydrolysis. Simons’ stain revealed that the accessible surface area of substrate significantly varied among these variants from 17.3 to 33.2 mg gmore » $$–1\\atop{biomass}$$ as reflected by dye adsorption, and cellulose accessibility was shown as one of the major factors governing substrates digestibility. HSQC and 31P NMR analysis detailed the structural features of poplar lignin variants. Overall, cellulose relevant factors appeared to have a stronger correlation with glucose release, if any, than lignin structural features. Lignin structural features, such as a phenolic hydroxyl group and the ratio of syringyl and guaiacyl (S/G), were found to have a more convincing impact on xylose release. Low lignin content, low cellulose DP, and high cellulose accessibility generally favor enzymatic hydrolysis; however, recalcitrance cannot be simply judged on any single substrate factor.« less

An in-depth understanding of biomass recalcitrance using natural poplar variants as the feedstock

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meng, Xianzhi; Pu, Yunqiao; Yoo, Chang Geun

Here, in an effort to better understand the biomass recalcitrance, six natural poplar variants were selected as feedstocks based on previous sugar release analysis. Compositional analysis and physicochemical characterizations of these poplars were performed and the correlations between these physicochemical properties and enzymatic hydrolysis yield were investigated. Gel permeation chromatography (GPC) and 13C solid state NMR were used to determine the degree of polymerization (DP) and crystallinity index (CrI) of cellulose, and the results along with the sugar release study indicated that cellulose DP likely played a more important role in enzymatic hydrolysis. Simons’ stain revealed that the accessible surface area of substrate significantly varied among these variants from 17.3 to 33.2 mg gmore » $$–1\\atop{biomass}$$ as reflected by dye adsorption, and cellulose accessibility was shown as one of the major factors governing substrates digestibility. HSQC and 31P NMR analysis detailed the structural features of poplar lignin variants. Overall, cellulose relevant factors appeared to have a stronger correlation with glucose release, if any, than lignin structural features. Lignin structural features, such as a phenolic hydroxyl group and the ratio of syringyl and guaiacyl (S/G), were found to have a more convincing impact on xylose release. Low lignin content, low cellulose DP, and high cellulose accessibility generally favor enzymatic hydrolysis; however, recalcitrance cannot be simply judged on any single substrate factor.« less

3D Shape and Structure of the Homunculus of eta Carinae

NASA Astrophysics Data System (ADS)

Currie, D. G.; Christou, J.; Tyler, D.; Jefferies, S.; Le Mignant, D.; Bonaccini, D.

2000-12-01

The three-dimensional shape of the Homunculus of eta Carinae, as well as the detailed features of the SouthEast Lobe have been observed using the ADONIS system on the ESO 3.6 meter telescope at La Silla. To measure the normally invisible back wall of the Homunculus, we have observed in the infrared (to reduce the opacity of the front wall) and used the Fabry-Perot Interferometer (to distinguish between the Doppler shifts of the light reflected from the back wall and the brighter light reflected from the front wall). This analysis confirms the Double-Flask model and the orientation of the symmetry axis obtained from the previous analysis of the front wall emission and the assumption of rotational symmetry (Currie et. al. 1995, Currie et. al. 1996, Dowling 1996). To evaluate the fine detail of the turbulent motions in the front wall of the SouthEast Lobe, we use broad band observations in the H and K bands. This will be compared to the similar features seen in the shorter wavelengths (at the same resolution) by the WFPC. In the infrared, we see more detail of the shear behavior already seen at the visible wavelengths (Dowling, 1996). To further explore these features, the results of several types of deconvolution will be considered in order to obtain the optimal resolution for the AO data, and to compare the different data processing methodologies. We wish to thank ESO for the observation time, and the 3.6 meter team for observational support. We also wish to thank the STScI and WFPC IDT team. Support for individual authors has come from ESO, the University of Maryland, AFOSR, and CfAO.

Complex Structure and Biochemical Characterization of the Staphylococcus aureus Cyclic Diadenylate Monophosphate (c-di-AMP)-binding Protein PstA, the Founding Member of a New Signal Transduction Protein Family*

PubMed Central

Campeotto, Ivan; Zhang, Yong; Mladenov, Miroslav G.; Freemont, Paul S.; Gründling, Angelika

2015-01-01

Signaling nucleotides are integral parts of signal transduction systems allowing bacteria to cope with and rapidly respond to changes in the environment. The Staphylococcus aureus PII-like signal transduction protein PstA was recently identified as a cyclic diadenylate monophosphate (c-di-AMP)-binding protein. Here, we present the crystal structures of the apo- and c-di-AMP-bound PstA protein, which is trimeric in solution as well as in the crystals. The structures combined with detailed bioinformatics analysis revealed that the protein belongs to a new family of proteins with a similar core fold but with distinct features to classical PII proteins, which usually function in nitrogen metabolism pathways in bacteria. The complex structure revealed three identical c-di-AMP-binding sites per trimer with each binding site at a monomer-monomer interface. Although distinctly different from other cyclic-di-nucleotide-binding sites, as the half-binding sites are not symmetrical, the complex structure also highlighted common features for c-di-AMP-binding sites. A comparison between the apo and complex structures revealed a series of conformational changes that result in the ordering of two anti-parallel β-strands that protrude from each monomer and allowed us to propose a mechanism on how the PstA protein functions as a signaling transduction protein. PMID:25505271

The devil is in the detail: brain dynamics in preparation for a global-local task.

PubMed

Leaver, Echo E; Low, Kathy A; DiVacri, Assunta; Merla, Arcangelo; Fabiani, Monica; Gratton, Gabriele

2015-08-01

When analyzing visual scenes, it is sometimes important to determine the relevant "grain" size. Attention control mechanisms may help direct our processing to the intended grain size. Here we used the event-related optical signal, a method possessing high temporal and spatial resolution, to examine the involvement of brain structures within the dorsal attention network (DAN) and the visual processing network (VPN) in preparation for the appropriate level of analysis. Behavioral data indicate that the small features of a hierarchical stimulus (local condition) are more difficult to process than the large features (global condition). Consistent with this finding, cues predicting a local trial were associated with greater DAN activation. This activity was bilateral but more pronounced in the left hemisphere, where it showed a frontal-to-parietal progression over time. Furthermore, the amount of DAN activation, especially in the left hemisphere and in parietal regions, was predictive of subsequent performance. Although local cues elicited left-lateralized DAN activity, no preponderantly right activity was observed for global cues; however, the data indicated an interaction between level of analysis (local vs. global) and hemisphere in VPN. They further showed that local processing involves structures in the ventral VPN, whereas global processing involves structures in the dorsal VPN. These results indicate that in our study preparation for analyzing different size features is an asymmetric process, in which greater preparation is required to focus on small rather than large features, perhaps because of their lesser salience. This preparation involves the same DAN used for other attention control operations.

Aggregating Data for Computational Toxicology Applications ...

EPA Pesticide Factsheets

Computational toxicology combines data from high-throughput test methods, chemical structure analyses and other biological domains (e.g., genes, proteins, cells, tissues) with the goals of predicting and understanding the underlying mechanistic causes of chemical toxicity and for predicting toxicity of new chemicals and products. A key feature of such approaches is their reliance on knowledge extracted from large collections of data and data sets in computable formats. The U.S. Environmental Protection Agency (EPA) has developed a large data resource called ACToR (Aggregated Computational Toxicology Resource) to support these data-intensive efforts. ACToR comprises four main repositories: core ACToR (chemical identifiers and structures, and summary data on hazard, exposure, use, and other domains), ToxRefDB (Toxicity Reference Database, a compilation of detailed in vivo toxicity data from guideline studies), ExpoCastDB (detailed human exposure data from observational studies of selected chemicals), and ToxCastDB (data from high-throughput screening programs, including links to underlying biological information related to genes and pathways). The EPA DSSTox (Distributed Structure-Searchable Toxicity) program provides expert-reviewed chemical structures and associated information for these and other high-interest public inventories. Overall, the ACToR system contains information on about 400,000 chemicals from 1100 different sources. The entire system is built usi

Functional MRI registration with tissue-specific patch-based functional correlation tensors.

PubMed

Zhou, Yujia; Zhang, Han; Zhang, Lichi; Cao, Xiaohuan; Yang, Ru; Feng, Qianjin; Yap, Pew-Thian; Shen, Dinggang

2018-06-01

Population studies of brain function with resting-state functional magnetic resonance imaging (rs-fMRI) rely on accurate intersubject registration of functional areas. This is typically achieved through registration using high-resolution structural images with more spatial details and better tissue contrast. However, accumulating evidence has suggested that such strategy cannot align functional regions well because functional areas are not necessarily consistent with anatomical structures. To alleviate this problem, a number of registration algorithms based directly on rs-fMRI data have been developed, most of which utilize functional connectivity (FC) features for registration. However, most of these methods usually extract functional features only from the thin and highly curved cortical grey matter (GM), posing great challenges to accurate estimation of whole-brain deformation fields. In this article, we demonstrate that additional useful functional features can also be extracted from the whole brain, not restricted to the GM, particularly the white-matter (WM), for improving the overall functional registration. Specifically, we quantify local anisotropic correlation patterns of the blood oxygenation level-dependent (BOLD) signals using tissue-specific patch-based functional correlation tensors (ts-PFCTs) in both GM and WM. Functional registration is then performed by integrating the features from different tissues using the multi-channel large deformation diffeomorphic metric mapping (mLDDMM) algorithm. Experimental results show that our method achieves superior functional registration performance, compared with conventional registration methods. © 2018 Wiley Periodicals, Inc.

Quasi-continuum photoluminescence: Unusual broad spectral and temporal characteristics found in defective surfaces of silica and other materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laurence, Ted A., E-mail: laurence2@llnl.gov; Bude, Jeff D.; Shen, Nan

2014-02-28

We previously reported a novel photoluminescence (PL) with a distribution of fast decay times in fused silica surface flaws that is correlated with damage propensity by high fluence lasers. The source of the PL was not attributable to any known silica point defect. Due to its broad spectral and temporal features, we here give this PL the name quasi-continuum PL (QC-PL) and describe the features of QC-PL in more detail. The primary features of QC-PL include broad excitation and emission spectra, a broad distribution of PL lifetimes from 20 ps to 5 ns, continuous shifts in PL lifetime distributions with respectmore » to emission wavelength, and a propensity to photo-bleach and photo-brighten. We found similar PL characteristics in surface flaws of other optical materials, including CaF{sub 2}, DKDP, and quartz. Based on the commonality of the features in different optical materials and the proximity of QC-PL to surfaces, we suggest that these properties arise from interactions associated with high densities of defects, rather than a distribution over a large number of types of defects and is likely found in a wide variety of structures from nano-scale composites to bulk structures as well as in both broad and narrow band materials from dielectrics to semiconductors.« less

A predictive transport modeling code for ICRF-heated tokamaks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, C.K.; Hwang, D.Q.; Houlberg, W.

In this report, a detailed description of the physic included in the WHIST/RAZE package as well as a few illustrative examples of the capabilities of the package will be presented. An in depth analysis of ICRF heating experiments using WHIST/RAZE will be discussed in a forthcoming report. A general overview of philosophy behind the structure of the WHIST/RAZE package, a summary of the features of the WHIST code, and a description of the interface to the RAZE subroutines are presented in section 2 of this report. Details of the physics contained in the RAZE code are examined in section 3.more » Sample results from the package follow in section 4, with concluding remarks and a discussion of possible improvements to the package discussed in section 5.« less

The Johnson Space Center management information systems: User's guide to JSCMIS

NASA Technical Reports Server (NTRS)

Bishop, Peter C.; Erickson, Lloyd

1990-01-01

The Johnson Space Center Management Information System (JSCMIS) is an interface to computer data bases at the NASA Johnson Space Center which allows an authorized user to browse and retrieve information from a variety of sources with minimum effort. The User's Guide to JSCMIS is the supplement to the JSCMIS Research Report which details the objectives, the architecture, and implementation of the interface. It is a tutorial on how to use the interface and a reference for details about it. The guide is structured like an extended JSCMIS session, describing all of the interface features and how to use them. It also contains an appendix with each of the standard FORMATs currently included in the interface. Users may review them to decide which FORMAT most suits their needs.

A predictive transport modeling code for ICRF-heated tokamaks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, C.K.; Hwang, D.Q.; Houlberg, W.

1992-02-01

In this report, a detailed description of the physic included in the WHIST/RAZE package as well as a few illustrative examples of the capabilities of the package will be presented. An in depth analysis of ICRF heating experiments using WHIST/RAZE will be discussed in a forthcoming report. A general overview of philosophy behind the structure of the WHIST/RAZE package, a summary of the features of the WHIST code, and a description of the interface to the RAZE subroutines are presented in section 2 of this report. Details of the physics contained in the RAZE code are examined in section 3.more » Sample results from the package follow in section 4, with concluding remarks and a discussion of possible improvements to the package discussed in section 5.« less

Thermographic analysis of waveguide-irradiated insect pupae

NASA Astrophysics Data System (ADS)

Olsen, Richard G.; Hammer, Wayne C.

1982-01-01

Pupae of the insect Tenebrio molitor L. were thermographically imaged during waveguide irradiation through longitudinal slots. T. molitor pupae have been subjects of microwave-induced teratology for a number of years, but until now the smallness of the insect has prevented detailed dosimetry. High-resolution thermographic imaging equipment was used to obtain the magnitude and spatial distribution of absorbed microwave energy at three frequencies, 1.3, 5.95, and 10 GHz. The detail of the thermal images obtained is sufficient to show the differential heating of structures as small as a single insect leg. Results show that the electrical properties of the head, thorax, and abdomen are sufficiently different to seriously impair the usefulness of any theoretical dosimetric model of homogeneous composition. Some general features of correlation with a slab model in waveguide are given.

Strategies for the profiling, characterisation and detailed structural analysis of N-linked oligosaccharides.

PubMed

Tharmalingam, Tharmala; Adamczyk, Barbara; Doherty, Margaret A; Royle, Louise; Rudd, Pauline M

2013-02-01

Many post-translational modifications, including glycosylation, are pivotal for the structural integrity, location and functional activity of glycoproteins. Sub-populations of proteins that are relocated or functionally changed by such modifications can change resting proteins into active ones, mediating specific effector functions, as in the case of monoclonal antibodies. To ensure safe and efficacious drugs it is essential to employ appropriate robust, quantitative analytical strategies that can (i) perform detailed glycan structural analysis, (ii) characterise specific subsets of glycans to assess known critical features of therapeutic activities (iii) rapidly profile glycan pools for at-line monitoring or high level batch to batch screening. Here we focus on these aspects of glycan analysis, showing how state-of-the-art technologies are required at all stages during the production of recombinant glycotherapeutics. These data can provide insights into processing pathways and suggest markers for intervention at critical control points in bioprocessing and also critical decision points in disease and drug monitoring in patients. Importantly, these tools are now enabling the first glycome/genome studies in large populations, allowing the integration of glycomics into other 'omics platforms in a systems biology context.

Spectroscopic and structural properties of 2,2'-dipyridylamine and its palladium and platinum complexes

NASA Astrophysics Data System (ADS)

Yurdakul, Ş.; Bilkana, M. T.

2015-10-01

The structural features such as geometric parameters, vibration frequencies and intensities of the vibrational bands of 2,2'-dipyridylamine ligand (DPA), its palladium (Pd(DPA)Cl2) and platinum (Pt(DPA)Cl2) complexes were studied by the density functional theory (DFT). The calculations were carried out by DFT / B3LYP method with 6-311++G(d,p) and LANL2DZ basis sets. All vibrational frequencies assigned in detail with the help of total energy distribution analysis (TED). Optimized geometric bond lengths and bond angles were compared with experimental X-ray data. Using DPA, K2PtCl4, and Na2PdCl4, the synthesized complex structures were characterized by the combination of elemental analysis, FT-IR (mid and far IR) and Raman spectroscopy.

An implementation of the programming structural synthesis system (PROSSS)

NASA Technical Reports Server (NTRS)

Rogers, J. L., Jr.; Sobieszczanski-Sobieski, J.; Bhat, R. B.

1981-01-01

A particular implementation of the programming structural synthesis system (PROSSS) is described. This software system combines a state of the art optimization program, a production level structural analysis program, and user supplied, problem dependent interface programs. These programs are combined using standard command language features existing in modern computer operating systems. PROSSS is explained in general with respect to this implementation along with the steps for the preparation of the programs and input data. Each component of the system is described in detail with annotated listings for clarification. The components include options, procedures, programs and subroutines, and data files as they pertain to this implementation. An example exercising each option in this implementation to allow the user to anticipate the type of results that might be expected is presented.

The Structure and Kinematics of Little Blue Spheroid Galaxies

NASA Astrophysics Data System (ADS)

Moffett, Amanda J.; Phillipps, Steven; Robotham, Aaron; Driver, Simon; Bremer, Malcolm; GAMA survey team, SAMI survey team

2018-01-01

A population of blue, morphologically early-type galaxies, dubbed "Little Blue Spheroids" (LBSs), has been identified as a significant contributor to the low redshift galaxy population in the GAMA survey. Using deep, high-resolution optical imaging from KiDS and the new Bayesian, two-dimensional galaxy profile modelling code PROFIT, we examine the detailed structural characteristics of LBSs, including low surface brightness components not detected in previous SDSS imaging. We find that these LBS galaxies combine features typical of early-type and late-type populations, with structural properties similar to other low-mass early types and star formation rates similar to low-mass late types. We further consider the environments and SAMI-derived IFU kinematics of LBSs in order to investigate the conditions of their formation and the current state of their dynamical evolution.

Lunar apennine-hadley region: geological inplications of Earth-based radar and infrared measurements.

PubMed

Zisk, S H; Carr, M H; Masursky, H; Shorthill, R W; Thompson, T W

1971-08-27

Recently completed high-resolution radar maps of the moon contain information on the decimeter-scale structure of the surface. When this information is combined with eclipse thermal-enhancement data and with high-resolution Lunar Orbiter photography, the surface morphology is revealed in some detail. A geological history for certain features and subareas can be developed, which provides one possible framework for the interpretation of the findings from the Apollo 15 landing. Frequency of decimeter-and meter-size blocks in and around lunar craters, given by the remote-sensed data, supports a multilayer structure in the Palus Putredinis mare region, as well as a great age for the bordering Apennine Mountains scarp.

Lunar Apennine-Hadley region: Geological implications of earth-based radar and infrared measurements

USGS Publications Warehouse

Zisk, S.H.; Carr, M.H.; Masursky, H.; Shorthill, R.W.; Thompson, T.W.

1971-01-01

Recently completed high-resolution radar maps of the moon contain information on the decimeter-scale structure of the surface. When this information is combined with eclipse thermal-enhancement data and with high-resolution Lunar Orbiter photography, the surface morphology is revealed in some detail. A geological history for certain features and subareas can be developed, which provides one possible framework for the interpretation of the findings from the Apollo 15 landing. Frequency of decimeter- and meter-size blocks in and around lunar craters, given by the remote-sensed data, supports a multilayer structure in the Palus Putredinis mare region, as well as a great age for the bordering Apennins Mountains scarp.

Climbing with adhesion: from bioinspiration to biounderstanding

PubMed Central

Cutkosky, Mark R.

2015-01-01

Bioinspiration is an increasingly popular design paradigm, especially as robots venture out of the laboratory and into the world. Animals are adept at coping with the variability that the world imposes. With advances in scientific tools for understanding biological structures in detail, we are increasingly able to identify design features that account for animals' robust performance. In parallel, advances in fabrication methods and materials are allowing us to engineer artificial structures with similar properties. The resulting robots become useful platforms for testing hypotheses about which principles are most important. Taking gecko-inspired climbing as an example, we show that the process of extracting principles from animals and adapting them to robots provides insights for both robotics and biology. PMID:26464786

Gravity field of the Moon from the Gravity Recovery and Interior Laboratory (GRAIL) mission.

PubMed

Zuber, Maria T; Smith, David E; Watkins, Michael M; Asmar, Sami W; Konopliv, Alexander S; Lemoine, Frank G; Melosh, H Jay; Neumann, Gregory A; Phillips, Roger J; Solomon, Sean C; Wieczorek, Mark A; Williams, James G; Goossens, Sander J; Kruizinga, Gerhard; Mazarico, Erwan; Park, Ryan S; Yuan, Dah-Ning

2013-02-08

Spacecraft-to-spacecraft tracking observations from the Gravity Recovery and Interior Laboratory (GRAIL) have been used to construct a gravitational field of the Moon to spherical harmonic degree and order 420. The GRAIL field reveals features not previously resolved, including tectonic structures, volcanic landforms, basin rings, crater central peaks, and numerous simple craters. From degrees 80 through 300, over 98% of the gravitational signature is associated with topography, a result that reflects the preservation of crater relief in highly fractured crust. The remaining 2% represents fine details of subsurface structure not previously resolved. GRAIL elucidates the role of impact bombardment in homogenizing the distribution of shallow density anomalies on terrestrial planetary bodies.

Superconducting heavy ion injector linac

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shepard, K.W.

1985-01-01

A conceptual design for a very low velocity (.007 < v/c < .07) superconducting heavy-ion linac is reviewed. This type of linac may have significant cost and performance advantages over room-temperature linacs, at least for applications requiring modest beam currents. Some general features of the design of very-low velocity superconducting accelerating structures are discussed and a design for a 48.5 MHz, v/c = .009 structure, together with the status of a niobium prototype, is discussed in detail. Preliminary results of a beam dynamics study indicate that the low velocity linac may be able to produce heavy-ion beams with time-energy spreadsmore » of a few keV-nsec. 11 refs, 4 figs.« less

Morphological analysis of hummocks in debris avalanche deposits using UAS-derived high-definition topographic data

NASA Astrophysics Data System (ADS)

Hayakawa, Yuichi S.; Obanawa, Hiroyuki; Yoshida, Hidetsugu; Naruhashi, Ryutaro; Okumura, Koji; Zaiki, Masumi

2016-04-01

Debris avalanche caused by sector collapse of a volcanic mountain often forms depositional landforms with characteristic surface morphology comprising hummocks. Geomorphological and sedimentological analyses of debris avalanche deposits (DAD) at the northeastern face of Mt. Erciyes in central Turkey have been performed to investigate the mechanisms and processes of the debris avalanche. The morphometry of hummocks provides an opportunity to examine the volumetric and kinematic characteristics of the DAD. Although the exact age has been unknown, the sector collapse of this DAD was supposed to have occurred in the late Pleistocene (sometime during 90-20 ka), and subsequent sediment supply from the DAD could have affected ancient human activities in the downstream basin areas. In order to measure detailed surface morphology and depositional structures of the DAD, we apply structure-from-motion multi-view stereo (SfM-MVS) photogrammetry using unmanned aerial system (UAS) and a handheld camera. The UAS, including small unmanned aerial vehicle (sUAV) and a digital camera, provides low-altitude aerial photographs to capture surface morphology for an area of several square kilometers. A high-resolution topographic data, as well as an orthorectified image, of the hummocks were then obtained from the digital elevation model (DEM), and the geometric features of the hummocks were examined. A handheld camera is also used to obtain photographs of outcrop face of the DAD along a road to support the seimentological investigation. The three-dimensional topographic models of the outcrop, with a panoramic orthorectified image projected on a vertical plane, were obtained. This data enables to effectively describe sedimentological structure of the hummock in DAD. The detailed map of the DAD is also further examined with a regional geomorphological map to be compared with other geomorphological features including fluvial valleys, terraces, lakes and active faults.

A Feathered Dinosaur Tail with Primitive Plumage Trapped in Mid-Cretaceous Amber.

PubMed

Xing, Lida; McKellar, Ryan C; Xu, Xing; Li, Gang; Bai, Ming; Persons, W Scott; Miyashita, Tetsuto; Benton, Michael J; Zhang, Jianping; Wolfe, Alexander P; Yi, Qiru; Tseng, Kuowei; Ran, Hao; Currie, Philip J

2016-12-19

In the two decades since the discovery of feathered dinosaurs [1-3], the range of plumage known from non-avialan theropods has expanded significantly, confirming several features predicted by developmentally informed models of feather evolution [4-10]. However, three-dimensional feather morphology and evolutionary patterns remain difficult to interpret, due to compression in sedimentary rocks [9, 11]. Recent discoveries in Cretaceous amber from Canada, France, Japan, Lebanon, Myanmar, and the United States [12-18] reveal much finer levels of structural detail, but taxonomic placement is uncertain because plumage is rarely associated with identifiable skeletal material [14]. Here we describe the feathered tail of a non-avialan theropod preserved in mid-Cretaceous (∼99 Ma) amber from Kachin State, Myanmar [17], with plumage structure that directly informs the evolutionary developmental pathway of feathers. This specimen provides an opportunity to document pristine feathers in direct association with a putative juvenile coelurosaur, preserving fine morphological details, including the spatial arrangement of follicles and feathers on the body, and micrometer-scale features of the plumage. Many feathers exhibit a short, slender rachis with alternating barbs and a uniform series of contiguous barbules, supporting the developmental hypothesis that barbs already possessed barbules when they fused to form the rachis [19]. Beneath the feathers, carbonized soft tissues offer a glimpse of preservational potential and history for the inclusion; abundant Fe 2+ suggests that vestiges of primary hemoglobin and ferritin remain trapped within the tail. The new finding highlights the unique preservation potential of amber for understanding the morphology and evolution of coelurosaurian integumentary structures. Copyright © 2016 Elsevier Ltd. All rights reserved.

Reconstruction of biofilm images: combining local and global structural parameters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Resat, Haluk; Renslow, Ryan S.; Beyenal, Haluk

2014-10-20

Digitized images can be used for quantitative comparison of biofilms grown under different conditions. Using biofilm image reconstruction, it was previously found that biofilms with a completely different look can have nearly identical structural parameters and that the most commonly utilized global structural parameters were not sufficient to uniquely define these biofilms. Here, additional local and global parameters are introduced to show that these parameters considerably increase the reliability of the image reconstruction process. Assessment using human evaluators indicated that the correct identification rate of the reconstructed images increased from 50% to 72% with the introduction of the new parametersmore » into the reconstruction procedure. An expanded set of parameters especially improved the identification of biofilm structures with internal orientational features and of structures in which colony sizes and spatial locations varied. Hence, the newly introduced structural parameter sets helped to better classify the biofilms by incorporating finer local structural details into the reconstruction process.« less

Time to face the fats: what can mass spectrometry reveal about the structure of lipids and their interactions with proteins?

PubMed

Brown, Simon H J; Mitchell, Todd W; Oakley, Aaron J; Pham, Huong T; Blanksby, Stephen J

2012-09-01

Since the 1950s, X-ray crystallography has been the mainstay of structural biology, providing detailed atomic-level structures that continue to revolutionize our understanding of protein function. From recent advances in this discipline, a picture has emerged of intimate and specific interactions between lipids and proteins that has driven renewed interest in the structure of lipids themselves and raised intriguing questions as to the specificity and stoichiometry in lipid-protein complexes. Herein we demonstrate some of the limitations of crystallography in resolving critical structural features of ligated lipids and thus determining how these motifs impact protein binding. As a consequence, mass spectrometry must play an important and complementary role in unraveling the complexities of lipid-protein interactions. We evaluate recent advances and highlight ongoing challenges towards the twin goals of (1) complete structure elucidation of low, abundant, and structurally diverse lipids by mass spectrometry alone, and (2) assignment of stoichiometry and specificity of lipid interactions within protein complexes.

Time to Face the Fats: What Can Mass Spectrometry Reveal about the Structure of Lipids and Their Interactions with Proteins?

NASA Astrophysics Data System (ADS)

Brown, Simon H. J.; Mitchell, Todd W.; Oakley, Aaron J.; Pham, Huong T.; Blanksby, Stephen J.

2012-09-01

Since the 1950s, X-ray crystallography has been the mainstay of structural biology, providing detailed atomic-level structures that continue to revolutionize our understanding of protein function. From recent advances in this discipline, a picture has emerged of intimate and specific interactions between lipids and proteins that has driven renewed interest in the structure of lipids themselves and raised intriguing questions as to the specificity and stoichiometry in lipid-protein complexes. Herein we demonstrate some of the limitations of crystallography in resolving critical structural features of ligated lipids and thus determining how these motifs impact protein binding. As a consequence, mass spectrometry must play an important and complementary role in unraveling the complexities of lipid-protein interactions. We evaluate recent advances and highlight ongoing challenges towards the twin goals of (1) complete structure elucidation of low, abundant, and structurally diverse lipids by mass spectrometry alone, and (2) assignment of stoichiometry and specificity of lipid interactions within protein complexes.

Ultra-Widefield Steering-Based SD-OCT Imaging of the Retinal Periphery

PubMed Central

Choudhry, Netan; Golding, John; Manry, Matthew W.; Rao, Rajesh C.

2016-01-01

Objective To describe the spectral-domain optical coherence tomography (SD-OCT) features of peripheral retinal findings using an ultra-widefield (UWF) steering technique to image the retinal periphery. Design Observational study. Participants 68 patients (68 eyes) with 19 peripheral retinal features. Main Outcome Measures SD-OCT-based structural features. Methods Nineteen peripheral retinal features including: vortex vein, congenital hypertrophy of the retinal pigment epithelium (CHRPE), pars plana, ora serrata pearl, typical cystoid degeneration (TCD), cystic retinal tuft, meridional fold, lattice and cobblestone degeneration, retinal hole, retinal tear, rhegmatogenous retinal detachment (RRD), typical degenerative senile retinoschisis, peripheral laser coagulation scars, ora tooth, cryopexy scars (retinal tear and treated retinoblastoma scar), bone spicules, white without pressure, and peripheral drusen were identified by peripheral clinical examination. Near infrared (NIR) scanning laser ophthalmoscopy (SLO) images and SD-OCT of these entities were registered to UWF color photographs. Results SD-OCT resolved structural features of all peripheral findings. Dilated hyporeflective tubular structures within the choroid were observed in the vortex vein. Loss of retinal lamination, neural retinal attenuation, RPE loss or hypertrophy were seen in several entities including CHRPE, ora serrata pearl, TCD, cystic retinal tuft, meridional fold, lattice and cobblestone degenerations. Hyporeflective intraretinal spaces, indicating cystoid or schitic fluid, were seen in ora serrata pearl, ora tooth, TCD, cystic retinal tuft, meridional fold, retinal hole, and typical degenerative senile retinoschisis. The vitreoretinal interface, which often consisted of lamellae-like structures of the condensed cortical vitreous near or adherent to the neural retina, appeared clearly in most peripheral findings, confirming its association with many low-risk and vision-threatening pathologies such as lattice degeneration, meridional folds, retinal breaks, and RRDs. Conclusions UWF steering technique-based SD-OCT imaging of the retinal periphery is feasible with current commercially available devices, and provides detailed anatomical information of the peripheral retina, including benign and pathological entities, not previously imaged. This imaging technique may deepen our structural understanding of these entities, their potentially associated macular and systemic pathologies, and may influence decision-making in clinical practice, particularly in areas with teleretinal capabilities but poor access to retinal specialists. PMID:26992837

Morphologic interpretation of fertile structures in glossopterid gymnosperms

USGS Publications Warehouse

Schopf, J.M.

1976-01-01

The problem of determining affinity among glossopterid gymnosperms is beset by deficiencies in preservation, natural dissociation of parts, and scarcity of features assuredly critical for morphologic comprarison. The glossopterids probably are not a very heterogeneous group of plants, but this is difficult to prove. The Gondwana glacial "hiatus" has resulted in the omission of a critical chapter glossopterid evolution. As a consequence, morphologic features and phyletic probabilities must be evaluated on a much more hypothetical basis than would otherwise be justified. Confusion has arisen from the lack of morphologic terms that permit clear discussion of a newly evolved type of reproductive structure in glossopterids. The structure, here designated a "fertiliger", consists of a leafy bract, a partially adnate stalk, and a fertile head or capitulum. Seven types of fertile structures are discussed, all of which are bilaterally symmetrical and have different features on dorsiventral surfaces. I regard all fertiligers as ovulate but this interpretation may bot be acceptable to some workers; others may not accept dorsiventral organization of the capitulum as being fundamental. Among glossopterids, however, in spite of differences in preservation that may seem to support a variant interpretation, these ovulate fertiligers are the distinctive features that show general consistency. A single fertile bract bearing several capitula, as exemplified by Lidgettonia, is called a compound fertiliger. Staminate structures (microsporophylls) of glossopterids are separately classified as Eretmonia, Glossotheca, and possibly as other taxa. Only the manner of sporangial attachment is not entirely clear. It seems likely the staminate parts have previously been confused with scale leaves and are actually coextensive in distribution with the glossopterids. A tentative phyletic model suggests the distant derivation of glossopterids from middle Carboniferous cordaiteans. Many details must be speculative due to the lack of a pertinent fossil record, but this interpretation accounts for some features that have no counterpart in pteridosperms. Permineralized ovules from Antarctica provide general support for this working hypothesis, but specific evidence is lacking. Furthermore, it seems unlikely angiosperms originated from glossopterids; it is more reasonable to consider the glossopterids as possible distant ancestors of the Gnetales. ?? 1976.

The virtual dissecting room: Creating highly detailed anatomy models for educational purposes.

PubMed

Zilverschoon, Marijn; Vincken, Koen L; Bleys, Ronald L A W

2017-01-01

Virtual 3D models are powerful tools for teaching anatomy. At the present day, there are a lot of different digital anatomy models, most of these commercial applications are based on a 3D model of a human body reconstructed from images with a 1mm intervals. The use of even smaller intervals may result in more details and more realistic appearances of 3D anatomy models. The aim of this study was to create a realistic and highly detailed 3D model of the hand and wrist based on small interval cross-sectional images, suitable for undergraduate and postgraduate teaching purposes with the possibility to perform a virtual dissection in an educational application. In 115 transverse cross-sections from a human hand and wrist, segmentation was done by manually delineating 90 different structures. With the use of Amira the segments were imported and a surface model/polygon model was created, followed by smoothening of the surfaces in Mudbox. In 3D Coat software the smoothed polygon models were automatically retopologied into a quadrilaterals formation and a UV map was added. In Mudbox, the textures from 90 structures were depicted in a realistic way by using photos from real tissue and afterwards height maps, gloss and specular maps were created to add more level of detail and realistic lightning on every structure. Unity was used to build a new software program that would support all the extra map features together with a preferred user interface. A 3D hand model has been created, containing 100 structures (90 at start and 10 extra structures added along the way). The model can be used interactively by changing the transparency, manipulating single or grouped structures and thereby simulating a virtual dissection. This model can be used for a variety of teaching purposes, ranging from undergraduate medical students to residents of hand surgery. Studying the hand and wrist anatomy using this model is cost-effective and not hampered by the limited access to real dissecting facilities. Copyright © 2016 Elsevier Inc. All rights reserved.

HUBBLE CAPTURES DETAILED IMAGE OF URANUS' ATMOSPHERE

NASA Technical Reports Server (NTRS)

2002-01-01

Hubble Space Telescope has peered deep into Uranus' atmosphere to see clear and hazy layers created by a mixture of gases. Using infrared filters, Hubble captured detailed features of three layers of Uranus' atmosphere. Hubble's images are different from the ones taken by the Voyager 2 spacecraft, which flew by Uranus 10 years ago. Those images - not taken in infrared light - showed a greenish-blue disk with very little detail. The infrared image allows astronomers to probe the structure of Uranus' atmosphere, which consists of mostly hydrogen with traces of methane. The red around the planet's edge represents a very thin haze at a high altitude. The haze is so thin that it can only be seen by looking at the edges of the disk, and is similar to looking at the edge of a soap bubble. The yellow near the bottom of Uranus is another hazy layer. The deepest layer, the blue near the top of Uranus, shows a clearer atmosphere. Image processing has been used to brighten the rings around Uranus so that astronomers can study their structure. In reality, the rings are as dark as black lava or charcoal. This false color picture was assembled from several exposures taken July 3, 1995 by the Wide Field Planetary Camera-2. CREDIT: Erich Karkoschka (University of Arizona Lunar and Planetary Lab) and NASA

Intramolecular Hydrogen Bonding in Benzoxazines: When Structural Design Becomes Functional.

PubMed

Froimowicz, Pablo; Zhang, Kan; Ishida, Hatsuo

2016-02-18

The future evolution of benzoxazines and polybenzoxazines as advanced molecular, structural, functional, engineering, and newly commercial materials depends to a great extent on a deeper and more fundamental understanding at the molecular level. In this contribution, the field of benzoxazines is briefly introduced along with a more detailed review of ortho-amide-functional benzoxazines, which are the main subjects of this article. Provided in this article are the detailed and solid scientific evidences of intramolecular five-membered-ring hydrogen bonding, which is supposed to be responsible for the unique and characteristic features exhibited by this ever-growing family of ortho-functionalized benzoxazines. One-dimensional (1D) (1)H NMR spectroscopy was used to study various concentrations of benzoxazines in various solvents with different hydrogen-bonding capability and at various temperatures to investigate in detail the nature of hydrogen bonding in both ortho-amide-functionalized benzoxazine and its para counterpart. These materials were further investigated by two-dimensional (2D) (1)H-(1)H nuclear Overhauser effect spectroscopy (NOESY) to verify and support the conclusions derived during the 1D (1)H NMR experiments. Only highly purified single-crystal benzoxazine samples have been used for this study to avoid additional interactions caused by any impurities. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Multiscale infrared and visible image fusion using gradient domain guided image filtering

NASA Astrophysics Data System (ADS)

Zhu, Jin; Jin, Weiqi; Li, Li; Han, Zhenghao; Wang, Xia

2018-03-01

For better surveillance with infrared and visible imaging, a novel hybrid multiscale decomposition fusion method using gradient domain guided image filtering (HMSD-GDGF) is proposed in this study. In this method, hybrid multiscale decomposition with guided image filtering and gradient domain guided image filtering of source images are first applied before the weight maps of each scale are obtained using a saliency detection technology and filtering means with three different fusion rules at different scales. The three types of fusion rules are for small-scale detail level, large-scale detail level, and base level. Finally, the target becomes more salient and can be more easily detected in the fusion result, with the detail information of the scene being fully displayed. After analyzing the experimental comparisons with state-of-the-art fusion methods, the HMSD-GDGF method has obvious advantages in fidelity of salient information (including structural similarity, brightness, and contrast), preservation of edge features, and human visual perception. Therefore, visual effects can be improved by using the proposed HMSD-GDGF method.

Detailed proteomic analysis on DM: insight into its hypoallergenicity.

PubMed

Bertino, Enrico; Gastaldi, Daniela; Monti, Giovanna; Baro, Cristina; Fortunato, Donatella; Perono Garoffo, Lorenza; Coscia, Alessandra; Fabris, Claudio; Mussap, Michele; Conti, Amedeo

2010-01-01

Successful therapy in cow milk (CM) protein allergy rests upon completely eliminating CM proteins from the child's diet: it is thus necessary to provide a replacement food. Donkey milk (DM) has recently aroused scientific and clinical interest, above all among paediatric allergologists. A deeper knowledge of proteins in DM is necessary to evaluate the immunological and physiological properties of this natural substitute for cow's milk. The paper offers a detailed comparative analysis among the protein fractions of DM, CM and human milk, following an extensive proteomic study of the casein and whey proteins of DM performed by narrow pH range 2-DE. The detailed protein composition and structural features reported in this study provide insight into the molecular reasons for the hypoallergenicity of DM. Whole DM might constitute a valid substitute of CM in feeding children with CM protein allergy and it might also constitute the basis for formulas suitable for allergic subjects in the first year of life.

Bayes Forest: a data-intensive generator of morphological tree clones

PubMed Central

Järvenpää, Marko; Åkerblom, Markku; Raumonen, Pasi; Kaasalainen, Mikko

2017-01-01

Abstract Detailed and realistic tree form generators have numerous applications in ecology and forestry. For example, the varying morphology of trees contributes differently to formation of landscapes, natural habitats of species, and eco-physiological characteristics of the biosphere. Here, we present an algorithm for generating morphological tree “clones” based on the detailed reconstruction of the laser scanning data, statistical measure of similarity, and a plant growth model with simple stochastic rules. The algorithm is designed to produce tree forms, i.e., morphological clones, similar (and not identical) in respect to tree-level structure, but varying in fine-scale structural detail. Although we opted for certain choices in our algorithm, individual parts may vary depending on the application, making it a general adaptable pipeline. Namely, we showed that a specific multipurpose procedural stochastic growth model can be algorithmically adjusted to produce the morphological clones replicated from the target experimentally measured tree. For this, we developed a statistical measure of similarity (structural distance) between any given pair of trees, which allows for the comprehensive comparing of the tree morphologies by means of empirical distributions describing the geometrical and topological features of a tree. Finally, we developed a programmable interface to manipulate data required by the algorithm. Our algorithm can be used in a variety of applications for exploration of the morphological potential of the growth models (both theoretical and experimental), arising in all sectors of plant science research. PMID:29020742

Crustal insights from gravity and aeromagnetic analysis: Central North Slope, Alaska

USGS Publications Warehouse

Saltus, R.W.; Potter, C.J.; Phillips, J.D.

2006-01-01

Aeromagnetic and gravity data are processed and interpreted to reveal deep and shallow information about the crustal structure of the central North Slope, Alaska. Regional aeromagnetic anomalies primarily reflect deep crustal features. Regional gravity anomalies are more complex and require detailed analysis. We constrain our geophysical models with seismic data and interpretations along two transects including the Trans-Alaska Crustal Transect. Combined geophysical analysis reveals a remarkable heterogeneity of the pre-Mississippian basement. In the central North Slope, pre-Mississippian basement consists of two distinct geophysical domains. To the southwest, the basement is dense and highly magnetic; this basement is likely mafic and mechanically strong, possibly acting as a buttress to basement involvement in Brooks Range thrusting. To the northeast, the central North Slope basement consists of lower density, moderately magnetic rocks with several discrete regions (intrusions?) of more magnetic rocks. A conjugate set of geophysical trends, northwest-southeast and southwest-northeast, may be a factor in the crustal response to tectonic compression in this domain. High-resolution gravity and aeromagnetic data, where available, reflect details of shallow fault and fold structure. The maps and profile models in this report should provide useful guidelines and complementary information for regional structural studies, particularly in combination with detailed seismic reflection interpretations. Future challenges include collection of high-resolution gravity and aeromagnetic data for the entire North Slope as well as additional deep crustal information from seismic, drilling, and other complementary methods. Copyrights ?? 2006. The American Association of Petroleum Geologists. All rights reserved.

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).

PubMed

Thebault, Philippe; Chirgadze, Dimitri Y; Dou, Zhen; Blundell, Tom L; Elowe, Sabine; Bolanos-Garcia, Victor M

2012-12-15

The SAC (spindle assembly checkpoint) is a surveillance system that ensures the timely and accurate transmission of the genetic material to offspring. The process implies kinetochore targeting of the mitotic kinases Bub1 (budding uninhibited by benzamidine 1), BubR1 (Bub1 related) and Mps1 (monopolar spindle 1), which is mediated by the N-terminus of each kinase. In the present study we report the 1.8 Å (1 Å=0.1 nm) crystal structure of the TPR (tetratricopeptide repeat) domain in the N-terminal region of human Mps1. The structure reveals an overall high similarity to the TPR motif of the mitotic checkpoint kinases Bub1 and BubR1, and a number of unique features that include the absence of the binding site for the kinetochore structural component KNL1 (kinetochore-null 1; blinkin), and determinants of dimerization. Moreover, we show that a stretch of amino acids at the very N-terminus of Mps1 is required for dimer formation, and that interfering with dimerization results in mislocalization and misregulation of kinase activity. The results of the present study provide an important insight into the molecular details of the mitotic functions of Mps1 including features that dictate substrate selectivity and kinetochore docking.

Structure Of The Core Of The Southern Vortex On Venus: VMC And VIRTIS Observations From Venus Express

NASA Astrophysics Data System (ADS)

Limaye, Sanjay; Baines, K. H.; Markiewicz, W.; Piccione, G.; Titov, D.; VMC Team; VIRTIS Team

2007-10-01

In April 2007, a special observational campaign was conducted from Venus Express using the high data rate transmissions available through a NASA DSN to obtain a movie of the South pole region of Venus. Previously, the VIRTIS observations showed a remarkable view of the hemispheric vortex centered roughly over the South pole with a well defined "S” shape structure within the core region. Concurrent ultraviolet (cloud top) and near infrared observations ( 50 km level) available from Venus Express enable us to examine the vertical structure in greater detail than possible before. Tracking of cloud features in the ultraviolet and near infrared data have been used to determine the horizontal flow at two levels. These results suggest that the horizontal (still dominantly zonal) flow in polar regions does not have large meridional shear. The morphology of the features seen in ultraviolet and near infrared data suggests that the core region does not rotate as a rigid cylinder, but exhibits twisting in the vertical. These observations provide us an insight into the structure of the global vortex circulation in the atmosphere of Venus, first detected in 1974 from Mariner 10 images. This research was supported by NASA Grant NNG06GC68G.

FRB121102 Bursts Show Detailed Spectrotemporal Structure

NASA Astrophysics Data System (ADS)

Hessels, Jason; Seymour, Andrew; Spitler, Laura; Michilli, Daniele; Lynch, Ryan S.; Gajjar, Vishal; Gourdji, Kelly

2018-01-01

FRB121102 is a sporadic emitter of millisecond-duration radio bursts, and is associated with a compact, persistent radio source in the primary star-forming region of a dwarf galaxy at ~ 1 Gpc. Key to understanding FRB121102's physical nature is using the observed burst properties to elucidate the underlying emission mechanism and its local environment. Here we present a sample of high signal-to-noise bursts that reveal hitherto unseen spectrotemporal features. We find that the bursts are often composed of sub-bursts with finite bandwidths, and characteristic frequencies that drift downwards during the burst. While this behavior could be an intrinsic feature of the burst emission mechanism, we also discuss an interpretation in terms of plasma lensing in the source environment, similar to the pulse echoes sometimes seen from the Crab pulsar.

Functional Utrastructure of Genlisea (Lentibulariaceae) Digestive Hairs

PubMed Central

Płachno, Bartosz Jan; Kozieradzka-Kiszkurno, Małgorzata; Świątek, Piotr

2007-01-01

Background and Aims Digestive structures of carnivorous plants produce external digestive enzymes, and play the main role in absorption. In Lentibulariaceae, the ultrastructure of digestive hairs has been examined in some detail in Pinguicula and Utricularia, but the sessile digestive hairs of Genlisea have received very little attention so far. The aim of this study was to fill this gap by expanding their morphological, anatomical and histochemical characterization. Methods Several imaging techniques were used, including light, confocal and electron microscopy, to reveal the structure and function of the secretory hairs of Genlisea traps. This report demonstrates the application of cryo-SEM for fast imaging of whole, physically fixed plant secretory structures. Key Results and Conclusion The concentration of digestive hairs along vascular bundles in subgenus Genlisea is a primitive feature, indicating its basal position within the genus. Digestive hairs of Genlisea consist of three compartments with different ultrastructure and function. In subgenus Tayloria the terminal hair cells are transfer cells, but not in species of subgenus Genlisea. A digestive pool of viscous fluid occurs in Genlisea traps. In spite of their similar architecture, the digestive-absorptive hairs of Lentibulariaceae feature differences in morphology and ultrastructure. PMID:17550910

Model of community emergence in weighted social networks

NASA Astrophysics Data System (ADS)

Kumpula, J. M.; Onnela, J.-P.; Saramäki, J.; Kertész, J.; Kaski, K.

2009-04-01

Over the years network theory has proven to be rapidly expanding methodology to investigate various complex systems and it has turned out to give quite unparalleled insight to their structure, function, and response through data analysis, modeling, and simulation. For social systems in particular the network approach has empirically revealed a modular structure due to interplay between the network topology and link weights between network nodes or individuals. This inspired us to develop a simple network model that could catch some salient features of mesoscopic community and macroscopic topology formation during network evolution. Our model is based on two fundamental mechanisms of network sociology for individuals to find new friends, namely cyclic closure and focal closure, which are mimicked by local search-link-reinforcement and random global attachment mechanisms, respectively. In addition we included to the model a node deletion mechanism by removing all its links simultaneously, which corresponds for an individual to depart from the network. Here we describe in detail the implementation of our model algorithm, which was found to be computationally efficient and produce many empirically observed features of large-scale social networks. Thus this model opens a new perspective for studying such collective social phenomena as spreading, structure formation, and evolutionary processes.

On the scaling features of high-latitude geomagnetic field fluctuations during a large geomagnetic storm

NASA Astrophysics Data System (ADS)

De Michelis, Paola; Federica Marcucci, Maria; Consolini, Giuseppe

2015-04-01

Recently we have investigated the spatial distribution of the scaling features of short-time scale magnetic field fluctuations using measurements from several ground-based geomagnetic observatories distributed in the northern hemisphere. We have found that the scaling features of fluctuations of the horizontal magnetic field component at time scales below 100 minutes are correlated with the geomagnetic activity level and with changes in the currents flowing in the ionosphere. Here, we present a detailed analysis of the dynamical changes of the magnetic field scaling features as a function of the geomagnetic activity level during the well-known large geomagnetic storm occurred on July, 15, 2000 (the Bastille event). The observed dynamical changes are discussed in relationship with the changes of the overall ionospheric polar convection and potential structure as reconstructed using SuperDARN data. This work is supported by the Italian National Program for Antarctic Research (PNRA) - Research Project 2013/AC3.08 and by the European Community's Seventh Framework Programme ([FP7/2007-2013]) under Grant no. 313038/STORM and

Solvent-accessible surface area: How well can be applied to hot-spot detection?

PubMed

Martins, João M; Ramos, Rui M; Pimenta, António C; Moreira, Irina S

2014-03-01

A detailed comprehension of protein-based interfaces is essential for the rational drug development. One of the key features of these interfaces is their solvent accessible surface area profile. With that in mind, we tested a group of 12 SASA-based features for their ability to correlate and differentiate hot- and null-spots. These were tested in three different data sets, explicit water MD, implicit water MD, and static PDB structure. We found no discernible improvement with the use of more comprehensive data sets obtained from molecular dynamics. The features tested were shown to be capable of discerning between hot- and null-spots, while presenting low correlations. Residue standardization such as rel SASAi or rel/res SASAi , improved the features as a tool to predict ΔΔGbinding values. A new method using support machine learning algorithms was developed: SBHD (Sasa-Based Hot-spot Detection). This method presents a precision, recall, and F1 score of 0.72, 0.81, and 0.76 for the training set and 0.91, 0.73, and 0.81 for an independent test set. Copyright © 2013 Wiley Periodicals, Inc.

Different Trichoscopic Features of Tinea Capitis and Alopecia Areata in Pediatric Patients

PubMed Central

El-Taweel, Abd-Elaziz; El-Esawy, Fatma; Abdel-Salam, Osama

2014-01-01

Background. Diagnosis of patchy hair loss in pediatric patients is often a matter of considerable debate among dermatologists. Trichoscopy is a rapid and noninvasive tool to detect more details of patchy hair loss. Like clinical dermatology, trichoscopy works parallel to the skin surface and perpendicular to the histological plane; like the histopathology, it thus allows the viewing of structures not discovered by the naked eye. Objective. Aiming to compare the different trichoscopic features of tinea capitis and alopecia areata in pediatric patients. Patients and Methods. This study included 40 patients, 20 patients with tinea capitis and 20 patients with alopecia areata. They were exposed toclinical examination, laboratory investigations (10% KOH and fungal culture), and trichoscope examination. Results. Our obtained results reported that, in tinea capitis patients, comma shaped hairs, corkscrew hairs, and zigzag shaped hairs are the diagnostic trichoscopic features of tinea capitis. While in alopecia areata patients, the most trichoscopic specific features were yellow dots, exclamation mark, and short vellus hairs. Conclusion. Trichoscopy can be used as a noninvasive tool for rapid diagnosis of tinea capitis and alopecia areata in pediatric patients. PMID:25024698

Classification of a wetland area along the upper Mississippi River with aerial videography

USGS Publications Warehouse

Jennings, C.A.; Vohs, P.A.; Dewey, M.R.

1992-01-01

We evaluated the use of aerial videography for classifying wetland habitats along the upper Mississippi River and found the prompt availability of habitat feature maps to be the major advantage of the video imagery technique. We successfully produced feature maps from digitized video images that generally agreed with the known distribution and areal coverages of the major habitat types independently identified and quantified with photointerpretation techniques. However, video images were not sufficiently detailed to allow us to consistently discriminate among the classes of aquatic macrophytes present or to quantify their areal coverage. Our inability to consistently distinguish among emergent, floating, and submergent macrophytes from the feature maps may have been related to the structural complexity of the site, to our limited vegetation sampling, and to limitations in video imagery. We expect that careful site selection (i.e., the desired level of resolution is available from video imagery) and additional vegetation samples (e.g., along a transect) will allow improved assignment of spectral values to specific plant types and enhance plant classification from feature maps produced from video imagery.

From Black Hole to Hydrate Hole: Gas hydrates, authigenic carbonates and vent biota as indicators of fluid migration at pockmark sites of the Northern Congo Fan

NASA Astrophysics Data System (ADS)

Kasten, S.; Schneider, R.; Spiess, V.; Cruise Participants Of M56b

2003-04-01

A recent high-resolution seismic, echosounder and video survey combined with detailed geological and geochemical sampling of pockmark sites on the Northern Congo Fan was carried out with RV Meteor in November/December 2002 in the frame of the project "CONGO" (BMBF/BEO "Geotechnologien"). These investigations revealed the extensive occurrence of surface and sub-surface gas hydrates as well as characteristic features of fluid venting such as clams (Calyptogena), tube worms (Pogonophera) and huge amounts of authigenic carbonates. In a first approach the patchyness in the occurrence of these features was mapped in relation to pockmark structure and seismic reflectors. Detailed sampling of three pockmarks by gravity corer showed that gas hydrates are present at and close to the sediment surface and often occur as several distinct layers and/or veins intercalated with hemipelagic muds. The depth of the upper boundary of these hydrate-bearing sediments increases from the center towards the edge of the pockmark structures. Pore water concentration profiles of sulfate and methane document the process of anaerobic methane oxidation above the hydrate-bearing layers. For those cores which contained several gas hydrate layers preliminary pore water profiles suggest the occurrence of more than one zone of anaerobic methane oxidation. Authigenic carbonates are found in high abundance, irregularly distributed within the pockmarks close to the sediment surface. These carbonates occur in a wide variety with respect to size, shape, structure and mineralogy. Their formation is associated with high amounts of bicarbonate released by the process of anaerobic methane oxidation. In the gravity cores authigenic carbonates are always present above hydrate-bearing sections. However, the quantities and characteristics of these authigenic minerals in relation to venting and microbial activity as well as to gas hydrate dissociation are not clear yet. Unraveling this relationship will be a major target of further investigation. By means of detailed studies of the sedimentary solid-phase, authigenic carbonates, clam layers and molecular biomarkers we will also try to reconstruct the history of venting and the dynamics of gas hydrate formation and decomposition in the Northern Congo fan area.

Importing perceived features into false memories.

PubMed

Lyle, Keith B; Johnson, Marcia K

2006-02-01

False memories sometimes contain specific details, such as location or colour, about events that never occurred. Based on the source-monitoring framework, we investigated one process by which false memories acquire details: the reactivation and misattribution of feature information from memories of similar perceived events. In Experiments 1A and 1B, when imagined objects were falsely remembered as seen, participants often reported that the objects had appeared in locations where visually or conceptually similar objects, respectively, had actually appeared. Experiment 2 indicated that colour and shape features of seen objects were misattributed to false memories of imagined objects. Experiment 3 showed that perceived details were misattributed to false memories of objects that had not been explicitly imagined. False memories that imported perceived features, compared to those that presumably did not, were subjectively more like memories for perceived events. Thus, perception may be even more pernicious than imagination in contributing to false memories.

Elucidation of the conformational free energy landscape in H.pylori LuxS and its implications to catalysis.

PubMed

Bhattacharyya, Moitrayee; Vishveshwara, Saraswathi

2010-08-12

One of the major challenges in understanding enzyme catalysis is to identify the different conformations and their populations at detailed molecular level in response to ligand binding/environment. A detail description of the ligand induced conformational changes provides meaningful insights into the mechanism of action of enzymes and thus its function. In this study, we have explored the ligand induced conformational changes in H.pylori LuxS and the associated mechanistic features. LuxS, a dimeric protein, produces the precursor (4,5-dihydroxy-2,3-pentanedione) for autoinducer-2 production which is a signalling molecule for bacterial quorum sensing. We have performed molecular dynamics simulations on H.pylori LuxS in its various ligand bound forms and analyzed the simulation trajectories using various techniques including the structure network analysis, free energy evaluation and water dynamics at the active site. The results bring out the mechanistic details such as co-operativity and asymmetry between the two subunits, subtle changes in the conformation as a response to the binding of active and inactive forms of ligands and the population distribution of different conformations in equilibrium. These investigations have enabled us to probe the free energy landscape and identify the corresponding conformations in terms of network parameters. In addition, we have also elucidated the variations in the dynamics of water co-ordination to the Zn2+ ion in LuxS and its relation to the rigidity at the active sites. In this article, we provide details of a novel method for the identification of conformational changes in the different ligand bound states of the protein, evaluation of ligand-induced free energy changes and the biological relevance of our results in the context of LuxS structure-function. The methodology outlined here is highly generalized to illuminate the linkage between structure and function in any protein of known structure.

Robust Classification and Segmentation of Planar and Linear Features for Construction Site Progress Monitoring and Structural Dimension Compliance Control

NASA Astrophysics Data System (ADS)

Maalek, R.; Lichti, D. D.; Ruwanpura, J.

2015-08-01

The application of terrestrial laser scanners (TLSs) on construction sites for automating construction progress monitoring and controlling structural dimension compliance is growing markedly. However, current research in construction management relies on the planned building information model (BIM) to assign the accumulated point clouds to their corresponding structural elements, which may not be reliable in cases where the dimensions of the as-built structure differ from those of the planned model and/or the planned model is not available with sufficient detail. In addition outliers exist in construction site datasets due to data artefacts caused by moving objects, occlusions and dust. In order to overcome the aforementioned limitations, a novel method for robust classification and segmentation of planar and linear features is proposed to reduce the effects of outliers present in the LiDAR data collected from construction sites. First, coplanar and collinear points are classified through a robust principal components analysis procedure. The classified points are then grouped using a robust clustering method. A method is also proposed to robustly extract the points belonging to the flat-slab floors and/or ceilings without performing the aforementioned stages in order to preserve computational efficiency. The applicability of the proposed method is investigated in two scenarios, namely, a laboratory with 30 million points and an actual construction site with over 150 million points. The results obtained by the two experiments validate the suitability of the proposed method for robust segmentation of planar and linear features in contaminated datasets, such as those collected from construction sites.

Complex Spiral Structure in the HD 100546 Transitional Disk as Revealed by GPI and MagAO

DOE Office of Scientific and Technical Information (OSTI.GOV)

Follette, Katherine B.; Macintosh, Bruce; Mullen, Wyatt

We present optical and near-infrared high-contrast images of the transitional disk HD 100546 taken with the Magellan Adaptive Optics system (MagAO) and the Gemini Planet Imager (GPI). GPI data include both polarized intensity and total intensity imagery, and MagAO data are taken in Simultaneous Differential Imaging mode at H α . The new GPI H -band total intensity data represent a significant enhancement in sensitivity and field rotation compared to previous data sets and enable a detailed exploration of substructure in the disk. The data are processed with a variety of differential imaging techniques (polarized, angular, reference, and simultaneous differentialmore » imaging) in an attempt to identify the disk structures that are most consistent across wavelengths, processing techniques, and algorithmic parameters. The inner disk cavity at 15 au is clearly resolved in multiple data sets, as are a variety of spiral features. While the cavity and spiral structures are identified at levels significantly distinct from the neighboring regions of the disk under several algorithms and with a range of algorithmic parameters, emission at the location of HD 100546 “ c ” varies from point-like under aggressive algorithmic parameters to a smooth continuous structure with conservative parameters, and is consistent with disk emission. Features identified in the HD 100546 disk bear qualitative similarity to computational models of a moderately inclined two-armed spiral disk, where projection effects and wrapping of the spiral arms around the star result in a number of truncated spiral features in forward-modeled images.« less

Cultural Resources Reconnaissance Along the Cheyenne River Arm of Lake Oahe in Dewey, Haakon, Stanley, and Ziebach Counties, South Dakota. Volume 1. Main Report

DTIC Science & Technology

1988-03-01

of site 39ST282................................227 39 Plan of site 39ST283................................230 40 Detailed plans of Features 1 and 2...268 53 Plan of site 39DW64 .............................. 272 54 Plan of Feature 1, site 39DW64 ................... 273 55 Plan of site 39DW65...facing E ........................... 228 46 Site 39ST283, facing NE .......................... 232 47 Detail of Feature 1, site 39ST283, facing NW

Ceramic Nanocomposites from Tailor-Made Preceramic Polymers

PubMed Central

Mera, Gabriela; Gallei, Markus; Bernard, Samuel; Ionescu, Emanuel

2015-01-01

The present Review addresses current developments related to polymer-derived ceramic nanocomposites (PDC-NCs). Different classes of preceramic polymers are briefly introduced and their conversion into ceramic materials with adjustable phase compositions and microstructures is presented. Emphasis is set on discussing the intimate relationship between the chemistry and structural architecture of the precursor and the structural features and properties of the resulting ceramic nanocomposites. Various structural and functional properties of silicon-containing ceramic nanocomposites as well as different preparative strategies to achieve nano-scaled PDC-NC-based ordered structures are highlighted, based on selected ceramic nanocomposite systems. Furthermore, prospective applications of the PDC-NCs such as high-temperature stable materials for thermal protection systems, membranes for hot gas separation purposes, materials for heterogeneous catalysis, nano-confinement materials for hydrogen storage applications as well as anode materials for secondary ion batteries are introduced and discussed in detail. PMID:28347023

DOE Office of Scientific and Technical Information (OSTI.GOV)

Janjusic, Tommy; Kartsaklis, Christos

Application analysis is facilitated through a number of program profiling tools. The tools vary in their complexity, ease of deployment, design, and profiling detail. Specifically, understand- ing, analyzing, and optimizing is of particular importance for scientific applications where minor changes in code paths and data-structure layout can have profound effects. Understanding how intricate data-structures are accessed and how a given memory system responds is a complex task. In this paper we describe a trace profiling tool, Glprof, specifically aimed to lessen the burden of the programmer to pin-point heavily involved data-structures during an application's run-time, and understand data-structure run-time usage.more » Moreover, we showcase the tool's modularity using additional cache simulation components. We elaborate on the tool's design, and features. Finally we demonstrate the application of our tool in the context of Spec bench- marks using the Glprof profiler and two concurrently running cache simulators, PPC440 and AMD Interlagos.« less

Modelling of double air-bridged structured inductor implemented by a GaAs integrated passive device manufacturing process

NASA Astrophysics Data System (ADS)

Li, Yang; Yao, Zhao; Zhang, Chun-Wei; Fu, Xiao-Qian; Li, Zhi-Ming; Li, Nian-Qiang; Wang, Cong

2017-05-01

In order to provide excellent performance and show the development of a complicated structure in a module and system, this paper presents a double air-bridge-structured symmetrical differential inductor based on integrated passive device technology. Corresponding to the proposed complicated structure, a new manufacturing process fabricated on a high-resistivity GaAs substrate is described in detail. Frequency-independent physical models are presented with lump elements and the results of skin effect-based measurements. Finally, some key features of the inductor are compared; good agreement between the measurements and modeled circuit fully verifies the validity of the proposed modeling approach. Meanwhile, we also present a comparison of different coil turns for inductor performance. The proposed work can provide a good solution for the design, fabrication, modeling, and practical application of radio-frequency modules and systems.

Structure of the Rigor Actin-Tropomyosin-Myosin Complex

PubMed Central

Behrmann, Elmar; Müller, Mirco; Penczek, Pawel A.; Mannherz, Hans Georg; Manstein, Dietmar J.; Raunser, Stefan

2014-01-01

The interaction of myosin with actin filaments is the central feature of muscle contraction and cargo movement along actin filaments of the cytoskeleton. Myosin converts the chemical energy stored in ATP into force and movement along actin filaments. Myosin binding to actin induces conformational changes that are coupled to the nucleotide-binding pocket and amplified by a specialized region of the motor domain for efficient force generation. Tropomyosin plays a key role in regulating the productive interaction between myosins and actin. Here, we report the 8 Å resolution structure of the actin-tropomyosin-myosin complex determined by cryo electron microscopy. The pseudo-atomic model of the complex obtained from fitting crystal structures into the map defines the large actin-myosin-tropomyosin interface and the molecular interactions between the proteins in detail and allows us to propose a structural model for tropomyosin dependent myosin binding to actin and actin-induced nucleotide release from myosin. PMID:22817895

Synchrotron x-ray microdiffraction reveals intrinsic structural features of amyloid deposits in situ.

PubMed

Briki, Fatma; Vérine, Jérôme; Doucet, Jean; Bénas, Philippe; Fayard, Barbara; Delpech, Marc; Grateau, Gilles; Riès-Kautt, Madeleine

2011-07-20

Amyloidoses are increasingly recognized as a major public health concern in Western countries. All amyloidoses share common morphological, structural, and tinctorial properties. These consist of staining by specific dyes, a fibrillar aspect in electron microscopy and a typical cross-β folding in x-ray diffraction patterns. Most studies that aim at deciphering the amyloid structure rely on fibers generated in vitro or extracted from tissues using protocols that may modify their intrinsic structure. Therefore, the fine details of the in situ architecture of the deposits remain unknown. Here, we present to our knowledge the first data obtained on ex vivo human renal tissue sections using x-ray microdiffraction. The typical cross-β features from fixed paraffin-embedded samples are similar to those formed in vitro or extracted from tissues. Moreover, the fiber orientation maps obtained across glomerular sections reveal an intrinsic texture that is correlated with the glomerulus morphology. These results are of the highest importance to understanding the formation of amyloid deposits and are thus expected to trigger new incentives for tissue investigation. Moreover, the access to intrinsic structural parameters such as fiber size and orientation using synchrotron x-ray microdiffraction, could provide valuable information concerning in situ mechanisms and deposit formation with potential benefits for diagnostic and therapeutic purposes. Copyright © 2011 Biophysical Society. Published by Elsevier Inc. All rights reserved.

The Nares Strait problem: A re-evaluation of the geological evidence in terms of a diffuse oblique-slip plate boundary between Greenland and the Canadian Arctic Islands

NASA Astrophysics Data System (ADS)

Miall, Andrew D.

1983-12-01

Geophysical models of sea floor spreading in Baffin Bay-Labrador Sea require that Greenland was displaced sinistrally relative to the Canadian Arctic Islands by 200-300 km. It has usually been assumed that this movement took place along Nares Strait, but onshore geological evidence recently compiled by Dawes and Kerr appears to rule out any displacement in excess of 50 km. Twenty different structural and stratigraphic markers cross the strait without significant displacement. A new approach is suggested here, which spreads the displacement across a diffuse oblique-slip plate boundary: (1) South of Bache Peninsula displacement of up to about 150 km may have occurred along Nares Strait. Bache Peninsula Arch probably did not cross the strait but is a north-south feature extending south from Bache Peninsula. (2) Revisions of Proterozoic stratigraphy show that the arch cannot have marked the limit of Thule Basin, as formerly assumed. Thule Basin isopach data can readily be accommodated to a 150 km sinistral displacement. (3) Cambrian-Ordovician strata in Bache Peninsula area may have occupied a north-south embayment similar to others along the southern border of Franklinian Geosyncline. (4) North of Bache Peninsula most of the strike-slip displacement probably took place along strike faults within Central Ellesmere and North Greenland fold belts. Paleozoic stratigraphic markers which cross Nares Strait without strike-slip displacement would not be displaced by these faults either, because stratigraphic and structural trends are parallel within the fold belts. The structural style of the Ellesmere fold belt is probably one of transpressive oblique-slip with local counterclockwise block rotations. (5) Up to 50 km of displacement may have occurred along northern Nares Strait itself, probably as a late phase of movement. A detailed palinspastic reconstruction must await further detailed groundwork. This should include the following (which would also serve as independent tests of the hypothesis): Detailed basin analysis of Thule Basin and Cambro-Ordovician strata immediately to the north; analysis of small scale structural features (joints, cleavage, slickenside) and map patterns of faults within the Central Ellesmere and North Greenland fold belts; deep reflection seismic and paleomagnetic analysis of the fold belts.

RStrucFam: a web server to associate structure and cognate RNA for RNA-binding proteins from sequence information.

PubMed

Ghosh, Pritha; Mathew, Oommen K; Sowdhamini, Ramanathan

2016-10-07

RNA-binding proteins (RBPs) interact with their cognate RNA(s) to form large biomolecular assemblies. They are versatile in their functionality and are involved in a myriad of processes inside the cell. RBPs with similar structural features and common biological functions are grouped together into families and superfamilies. It will be useful to obtain an early understanding and association of RNA-binding property of sequences of gene products. Here, we report a web server, RStrucFam, to predict the structure, type of cognate RNA(s) and function(s) of proteins, where possible, from mere sequence information. The web server employs Hidden Markov Model scan (hmmscan) to enable association to a back-end database of structural and sequence families. The database (HMMRBP) comprises of 437 HMMs of RBP families of known structure that have been generated using structure-based sequence alignments and 746 sequence-centric RBP family HMMs. The input protein sequence is associated with structural or sequence domain families, if structure or sequence signatures exist. In case of association of the protein with a family of known structures, output features like, multiple structure-based sequence alignment (MSSA) of the query with all others members of that family is provided. Further, cognate RNA partner(s) for that protein, Gene Ontology (GO) annotations, if any and a homology model of the protein can be obtained. The users can also browse through the database for details pertaining to each family, protein or RNA and their related information based on keyword search or RNA motif search. RStrucFam is a web server that exploits structurally conserved features of RBPs, derived from known family members and imprinted in mathematical profiles, to predict putative RBPs from sequence information. Proteins that fail to associate with such structure-centric families are further queried against the sequence-centric RBP family HMMs in the HMMRBP database. Further, all other essential information pertaining to an RBP, like overall function annotations, are provided. The web server can be accessed at the following link: http://caps.ncbs.res.in/rstrucfam .

Shape Adaptive, Robust Iris Feature Extraction from Noisy Iris Images

PubMed Central

Ghodrati, Hamed; Dehghani, Mohammad Javad; Danyali, Habibolah

2013-01-01

In the current iris recognition systems, noise removing step is only used to detect noisy parts of the iris region and features extracted from there will be excluded in matching step. Whereas depending on the filter structure used in feature extraction, the noisy parts may influence relevant features. To the best of our knowledge, the effect of noise factors on feature extraction has not been considered in the previous works. This paper investigates the effect of shape adaptive wavelet transform and shape adaptive Gabor-wavelet for feature extraction on the iris recognition performance. In addition, an effective noise-removing approach is proposed in this paper. The contribution is to detect eyelashes and reflections by calculating appropriate thresholds by a procedure called statistical decision making. The eyelids are segmented by parabolic Hough transform in normalized iris image to decrease computational burden through omitting rotation term. The iris is localized by an accurate and fast algorithm based on coarse-to-fine strategy. The principle of mask code generation is to assign the noisy bits in an iris code in order to exclude them in matching step is presented in details. An experimental result shows that by using the shape adaptive Gabor-wavelet technique there is an improvement on the accuracy of recognition rate. PMID:24696801

Shape adaptive, robust iris feature extraction from noisy iris images.

PubMed

Ghodrati, Hamed; Dehghani, Mohammad Javad; Danyali, Habibolah

2013-10-01

In the current iris recognition systems, noise removing step is only used to detect noisy parts of the iris region and features extracted from there will be excluded in matching step. Whereas depending on the filter structure used in feature extraction, the noisy parts may influence relevant features. To the best of our knowledge, the effect of noise factors on feature extraction has not been considered in the previous works. This paper investigates the effect of shape adaptive wavelet transform and shape adaptive Gabor-wavelet for feature extraction on the iris recognition performance. In addition, an effective noise-removing approach is proposed in this paper. The contribution is to detect eyelashes and reflections by calculating appropriate thresholds by a procedure called statistical decision making. The eyelids are segmented by parabolic Hough transform in normalized iris image to decrease computational burden through omitting rotation term. The iris is localized by an accurate and fast algorithm based on coarse-to-fine strategy. The principle of mask code generation is to assign the noisy bits in an iris code in order to exclude them in matching step is presented in details. An experimental result shows that by using the shape adaptive Gabor-wavelet technique there is an improvement on the accuracy of recognition rate.

Thermal Protection System of the Space Shuttle

NASA Technical Reports Server (NTRS)

Cleland, John; Iannetti, Francesco

1989-01-01

The Thermal Protection System (TPS), introduced by NASA, continues to incorporate many of the advances in materials over the past two decades. A comprehensive, single-volume summary of the TPS, including system design rationales, key design features, and broad descriptions of the subsystems of TPS (E.g., reusable surface insulation, leading edge structural, and penetration subsystems) is provided. Details of all elements of TPS development and application are covered (materials properties, manufacturing, modeling, testing, installation, and inspection). Disclosures and inventions are listed and potential commercial application of TPS-related technology is discussed.

Project Prospector: Unmanned Exploration and Apollo Support Program

NASA Technical Reports Server (NTRS)

1969-01-01

Prior to the establishment of a manned lunar observatory or base, it is essential that a compendium of information be available on the environment, composition, structure, and topography of the moon. In an effort to satisfy this need for improved and detailed information, NASA has undertaken a lunar program which ranges from the utilization of circumlunar flight vehicles, equipped with automatic photographic and radiation measuring equipment which responds to commands from the earth, to actual determination of surface composition and features obtained from unmanned instrumented spacecraft which impact the moon.

Space Shuttle - Bringing cryohydrogen technology down to earth. [details of LH2 and LO2 technology and External Tank design

NASA Technical Reports Server (NTRS)

Odom, J. B.

1978-01-01

The External Tank must provide a safe storage container for both LH2 and LO2, a means of maintaining propellant quality in order to meet the engine pump net positive suction pressure requirements, and a structural strong-back for the Space Shuttle system, all at the minimum recurring cost and weight, while maintaining quality and reliability. The present paper summarizes External Tank design features and discusses the advantages of using LH2 and LO2 for the Space Shuttle system.

Earth observations taken by the Expedition Seven crew

NASA Image and Video Library

2003-10-11

ISS007-E-17038 (11 October 2003) --- This view featuring a close-up of the Salton Sea was taken by an Expedition 7 crewmember onboard the International Space Station (ISS). The image provides detail of the structure of the algal bloom. These blooms continue to be a problem for the Salton Sea. They are caused by high concentrations of nutrients, especially nitrogen and phosphorous, which drain into the basin from the agricultural run-off. As the algae die and decompose, oxygen levels in the sea drop, causing fish kills and hazardous condition for other wildlife.

Named Entity Recognition in a Hungarian NL Based QA System

NASA Astrophysics Data System (ADS)

Tikkl, Domonkos; Szidarovszky, P. Ferenc; Kardkovacs, Zsolt T.; Magyar, Gábor

In WoW project our purpose is to create a complex search interface with the following features: search in the deep web content of contracted partners' databases, processing Hungarian natural language (NL) questions and transforming them to SQL queries for database access, image search supported by a visual thesaurus that describes in a structural form the visual content of images (also in Hungarian). This paper primarily focuses on a particular problem of question processing task: the entity recognition. Before going into details we give a short overview of the project's aims.

Reflectance confocal microscopy of cutaneous melanoma. Correlation with dermoscopy and histopathology*

PubMed Central

Rstom, Silvia Arroyo; Libório, Lorena Silva; Paschoal, Francisco Macedo

2015-01-01

In vivo Confocal Microscopy is a method for non-invasive, real-time visualization of microscopic structures and cellular details of the epidermis and dermis, which has a degree of resolution similar to that obtained with histology. We present a case of cutaneous melanoma in which diagnosis was aided by confocal microscopy examination. We also correlate the observed features with the dermoscopic and histopathological findings. Confocal microscopy proved to be an useful adjunct to dermoscopy, playing an important role as a method 'between clinical evaluation and histopathology'. PMID:26131877

NASA-ARC 91.5-cm airborne infrared telescope. [tracking mechanism

NASA Technical Reports Server (NTRS)

Mobley, R. E.; Brown, T. M.

1979-01-01

A 91.5 cm aperture telescope installed aboard NASA-Lockheed C-141A aircraft for the performance of infrared astronomy is described. A unique feature of the telescope is that its entire structure is supported by a 41 cm spherical air bearing which effectively uncouples it from aircraft angular motion, and with inertial stabilization and star tracking, limits tracking errors to less than 1 arc second in most applications. A general description of the system, a summary of its performance, and a detailed description of an offset tracking mechanism is presented.

Exploration and discovery in Yellowstone Lake: Results from high-resolution sonar imaging, seismic reflection profiling, and submersible studies

USGS Publications Warehouse

Morgan, L.A.; Shanks, Wayne C.; Lovalvo, D.A.; Johnson, S.Y.; Stephenson, W.J.; Pierce, K.L.; Harlan, S.S.; Finn, C.A.; Lee, G.; Webring, M.; Schulze, B.; Duhn, J.; Sweeney, R.; Balistrieri, L.

2003-01-01

Discoveries from multi-beam sonar mapping and seismic reflection surveys of the northern, central, and West Thumb basins of Yellowstone Lake provide new insight into the extent of post-collapse volcanism and active hydrothermal processes occurring in a large lake environment above a large magma chamber. Yellowstone Lake has an irregular bottom covered with dozens of features directly related to hydrothermal, tectonic, volcanic, and sedimentary processes. Detailed bathymetric, seismic reflection, and magnetic evidence reveals that rhyolitic lava flows underlie much of Yellowstone Lake and exert fundamental control on lake bathymetry and localization of hydrothermal activity. Many previously unknown features have been identified and include over 250 hydrothermal vents, several very large (>500 m diameter) hydrothermal explosion craters, many small hydrothermal vent craters (???1-200 m diameter), domed lacustrine sediments related to hydrothermal activity, elongate fissures cutting post-glacial sediments, siliceous hydrothermal spire structures, sublacustrine landslide deposits, submerged former shorelines, and a recently active graben. Sampling and observations with a submersible remotely operated vehicle confirm and extend our understanding of the identified features. Faults, fissures, hydrothermally inflated domal structures, hydrothermal explosion craters, and sublacustrine landslides constitute potentially significant geologic hazards. Toxic elements derived from hydrothermal processes also may significantly affect the Yellowstone ecosystem. Published by Elsevier Science B.V.

[Fundamentals of plasma chemistry and its application to drug engineering].

PubMed

Kuzuya, M

1996-04-01

In this review, our novel research works in both low temperature plasma chemistry and solid state plasma chemistry were described. As for low temperature plasma, the ESR study on plasma-induced radicals of several selected conventional polymers was shown including the detailed analyses of the radical structure and the mechanism by which the radicals were formed on typical degradable methacrylic polymers and cross-linkable polystyrene. One of the pharmaceutical applications of the plasma processing for drug delivery system (DDS) was also described, which includes the preparations of double-compressed tablet consisting of drugs as a core material and various types of polymers as a wall material followed by plasma-irradiation on such a tablet. As for solid state plasma, the detailed reaction mechanism of solid state mechanochemical polymerization was shown including the solid state single electron transfer and the special feature of the resulting polymers. The structural criteria for polymerizable monomer derived from the quantum chemical considerations were also established. Based on the above findings, we synthesized various polymeric prodrugs by mechanochemical polymerization and studied the nature of hydrolyses (drug release).

Functional diversity of potassium channel voltage-sensing domains.

PubMed

Islas, León D

2016-01-01

Voltage-gated potassium channels or Kv's are membrane proteins with fundamental physiological roles. They are composed of 2 main functional protein domains, the pore domain, which regulates ion permeation, and the voltage-sensing domain, which is in charge of sensing voltage and undergoing a conformational change that is later transduced into pore opening. The voltage-sensing domain or VSD is a highly conserved structural motif found in all voltage-gated ion channels and can also exist as an independent feature, giving rise to voltage sensitive enzymes and also sustaining proton fluxes in proton-permeable channels. In spite of the structural conservation of VSDs in potassium channels, there are several differences in the details of VSD function found across variants of Kvs. These differences are mainly reflected in variations in the electrostatic energy needed to open different potassium channels. In turn, the differences in detailed VSD functioning among voltage-gated potassium channels might have physiological consequences that have not been explored and which might reflect evolutionary adaptations to the different roles played by Kv channels in cell physiology.

Functional diversity of potassium channel voltage-sensing domains

PubMed Central

Islas, León D.

2016-01-01

Abstract Voltage-gated potassium channels or Kv's are membrane proteins with fundamental physiological roles. They are composed of 2 main functional protein domains, the pore domain, which regulates ion permeation, and the voltage-sensing domain, which is in charge of sensing voltage and undergoing a conformational change that is later transduced into pore opening. The voltage-sensing domain or VSD is a highly conserved structural motif found in all voltage-gated ion channels and can also exist as an independent feature, giving rise to voltage sensitive enzymes and also sustaining proton fluxes in proton-permeable channels. In spite of the structural conservation of VSDs in potassium channels, there are several differences in the details of VSD function found across variants of Kvs. These differences are mainly reflected in variations in the electrostatic energy needed to open different potassium channels. In turn, the differences in detailed VSD functioning among voltage-gated potassium channels might have physiological consequences that have not been explored and which might reflect evolutionary adaptations to the different roles played by Kv channels in cell physiology. PMID:26794852

The F-15B Propulsion Flight Test Fixture: A New Flight Facility For Propulsion Research

NASA Technical Reports Server (NTRS)

Corda, Stephen; Vachon, M. Jake; Palumbo, Nathan; Diebler, Corey; Tseng, Ting; Ginn, Anthony; Richwine, David

2001-01-01

The design and development of the F-15B Propulsion Flight Test Fixture (PFTF), a new facility for propulsion flight research, is described. Mounted underneath an F-15B fuselage, the PFTF provides volume for experiment systems and attachment points for propulsion devices. A unique feature of the PFTF is the incorporation of a six-degree-of-freedom force balance. Three-axis forces and moments can be measured in flight for experiments mounted to the force balance. The NASA F-15B airplane is described, including its performance and capabilities as a research test bed aircraft. The detailed description of the PFTF includes the geometry, internal layout and volume, force-balance operation, available instrumentation, and allowable experiment size and weight. The aerodynamic, stability and control, and structural designs of the PFTF are discussed, including results from aerodynamic computational fluid dynamic calculations and structural analyses. Details of current and future propulsion flight experiments are discussed. Information about the integration of propulsion flight experiments is provided for the potential PFTF user.

Smart wing wind tunnel model design

NASA Astrophysics Data System (ADS)

Martin, Christopher A.; Jasmin, Larry; Flanagan, John S.; Appa, Kari; Kudva, Jayanth N.

1997-05-01

To verify the predicted benefits of the smart wing concept, two 16% scale wind tunnel models, one conventional and the other incorporating smart wing design features, were designed, fabricated and tested. Meticulous design of the two models was essential to: (1) ensure the required factor of safety of four for operation in the NASA Langley TDT wind tunnel, (2) efficiently integrate the smart actuation systems, (3) quantify the performance improvements, and (4) facilitate eventual scale-up to operational aircraft. Significant challenges were encountered in designing the attachment of the shape memory alloy control surfaces to the wing box, integration of the SMA torque tube in the wing structure, and development of control mechanisms to protect the model and the tunnel in the event of failure of the smart systems. In this paper, detailed design of the two models are presented. First, dynamic scaling of the models based on the geometry and structural details of the full- scale aircraft is presented. Next, results of the stress, divergence and flutter analyses are summarized. Finally some of the challenges of integrating the smart actuators with the model are highlighted.

Imaging the Buried Chicxulub Crater with Gravity Gradients and Cenotes

NASA Astrophysics Data System (ADS)

Hildebrand, A. R.; Pilkington, M.; Halpenny, J. F.; Ortiz-Aleman, C.; Chavez, R. E.; Urrutia-Fucugauchi, J.; Connors, M.; Graniel-Castro, E.; Camara-Zi, A.; Vasquez, J.

1995-09-01

Differing interpretations of the Bouguer gravity anomaly over the Chicxulub crater, Yucatan Peninsula, Mexico, have yielded diameter estimates of 170 to 320 km. Knowing the crater's size is necessary to quantify the lethal perturbations to the Cretaceous environment associated with its formation. The crater's size (and internal structure) is revealed by the horizontal gradient of the Bouguer gravity anomaly over the structure, and by mapping the karst features of the Yucatan region. To improve our resolution of the crater's gravity signature we collected additional gravity measurements primarily along radial profiles, but also to fill in previously unsurveyed areas. Horizontal gradient analysis of Bouguer gravity data objectively highlights the lateral density contrasts of the impact lithologies and suppresses regional anomalies which may obscure the gravity signature of the Chicxulub crater lithologies. This gradient technique yields a striking circular structure with at least 6 concentric gradient features between 25 and 85 km radius. These features are most distinct in the southwest probably because of denser sampling of the gravity field. Our detailed profiles detected an additional feature and steeper gradients (up to 5 mGal/km) than the original survey. We interpret the outer four gradient maxima to represent concentric faults in the crater's zone of slumping as is also revealed by seismic reflection data. The inner two probably represent the margin of the central uplift and the peak ring and or collapsed transient cavity. Radial gradients in the SW quadrant over the inferred ~40 km-diameter central uplift (4) may represent structural "puckering" as revealed at eroded terrestrial craters. Gradient features related to regional gravity highs and lows are visible outside the crater, but no concentric gradient features are apparent at distances > 90 km radius. The marginal gradient features may be modelled by slump faults as observed in large complex craters on the other terrestrial planets. A modeled fault of 1.5 km displacement (slightly slumped block exterior and impact breccia interior) reproduces the steepest gradient feature. This model is incompatible with models that place these gradient features inside the collapsed transient cavity. Locations of the karst features of the northern Yucatan region were digitized from 1:50,000 topographic maps, which show most but not all the water-filled sinkholes (locally known as cenotes). A prominent ring of cenotes is visible over the crater that is spatially correlated to the outer steep gravity gradient feature. The mapped cenotes constitute an unbiased sampling of the region's karst surface features of >50 m diameter. The gradient maximum and the cenote ring both meander with amplitudes of up to 2 km. The wiggles in the gradient feature and the cenote distribution probably correspond to the "scalloping" observed at the headwall of terraces in large complex craters. A second partial cenote ring exterior to the southwest side of the main ring corresponds to a less-prominent gravity gradient feature. No concentric structure is observable in the distribution of karst features at radii >90 km. The cenote ring is bounded by the outer peripheral steep gradient feature and must be related to it; the slump faults must have been reactivated sufficiently to create fracturing in the overlying and much younger sediment. Long term subsidence, as found at other terrestrial craters is a possible mechanism for the reactivation. Such long term subsidence may be caused by differential compaction or thermal relaxation. Elevations acquired during gravity surveys show that the cenote ring also corresponds to a topographic low along some of its length that probably reflects preferential erosion.

Development and Application of a Three-Dimensional Finite Element Vapor Intrusion Model

PubMed Central

Pennell, Kelly G.; Bozkurt, Ozgur; Suuberg, Eric M.

2010-01-01

Details of a three-dimensional finite element model of soil vapor intrusion, including the overall modeling process and the stepwise approach, are provided. The model is a quantitative modeling tool that can help guide vapor intrusion characterization efforts. It solves the soil gas continuity equation coupled with the chemical transport equation, allowing for both advective and diffusive transport. Three-dimensional pressure, velocity, and chemical concentration fields are produced from the model. Results from simulations involving common site features, such as impervious surfaces, porous foundation sub-base material, and adjacent structures are summarized herein. The results suggest that site-specific features are important to consider when characterizing vapor intrusion risks. More importantly, the results suggest that soil gas or subslab gas samples taken without proper regard for particular site features may not be suitable for evaluating vapor intrusion risks; rather, careful attention needs to be given to the many factors that affect chemical transport into and around buildings. PMID:19418819

The Narrow Cold-Frontal Rainband of 22/23 November 2013

NASA Technical Reports Server (NTRS)

Kidd, Christopher

2015-01-01

The recent paper in Weather by Young (2014) provided a detailed analysis of an intensive cold front as it passed over the UK on 2223 November 2013. This was an extremely good example of linear convection, as it is described in the paper, or a narrow cold-frontal rainband (NCFR; Hobbs and Biswas, 1979). These features are associated with a low-level jet that lies ahead and parallel to the surface cold front, generating a band of intense but relatively shallow convection (see Koch and Kocin, 1991). Although the structure associated with these systems is not uncommon (e.g. Gatzen, 2011), this case was notable for the (linear) length and the longevity of the feature. Critically, fine-scale radar observations using the 1km, 5min UK composite radar product, produced by the UK Met Office and supplied by the British Atmospheric Data Centre, enabled the timing and progression of the most intense band of this feature tobe examined (see Figure 1).

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities.

PubMed

Ferreira, Isabel C F R; Heleno, Sandrina A; Reis, Filipa S; Stojkovic, Dejan; Queiroz, Maria João R P; Vasconcelos, M Helena; Sokovic, Marina

2015-06-01

Ganoderma genus comprises one of the most commonly studied species worldwide, Ganoderma lucidum. However, other Ganoderma species have been also reported as important sources of bioactive compounds. Polysaccharides are important contributors to the medicinal properties reported for Ganoderma species, as demonstrated by the numerous publications, including reviews, on this matter. Yet, what are the chemical features of Ganoderma polysaccharides that have bioactivity? In the present manuscript, the chemical features of Ganoderma polysaccharides with reported antioxidant, antitumor and antimicrobial activities (the most studied worldwide) are analyzed in detail. The composition of sugars (homo- versus hetero-glucans and other polysaccharides), type of glycosidic linkages, branching patterns, and linkage to proteins are discussed. Methods for extraction, isolation and identification are evaluated and, finally, the bioactivity of polysaccharidic extracts and purified compounds are discussed. The integration of data allows deduction of structure-activity relationships and gives clues to the chemical aspects involved in Ganoderma bioactivity. Copyright © 2014 Elsevier Ltd. All rights reserved.

X-ray crystallography and its impact on understanding bacterial cell wall remodeling processes.

PubMed

Büttner, Felix Michael; Renner-Schneck, Michaela; Stehle, Thilo

2015-02-01

The molecular structure of matter defines its properties and function. This is especially true for biological macromolecules such as proteins, which participate in virtually all biochemical processes. A three dimensional structural model of a protein is thus essential for the detailed understanding of its physiological function and the characterization of essential properties such as ligand binding and reaction mechanism. X-ray crystallography is a well-established technique that has been used for many years, but it is still by far the most widely used method for structure determination. A particular strength of this technique is the elucidation of atomic details of molecular interactions, thus providing an invaluable tool for a multitude of scientific projects ranging from the structural classification of macromolecules over the validation of enzymatic mechanisms or the understanding of host-pathogen interactions to structure-guided drug design. In the first part of this review, we describe essential methodological and practical aspects of X-ray crystallography. We provide some pointers that should allow researchers without a background in structural biology to assess the overall quality and reliability of a crystal structure. To highlight its potential, we then survey the impact X-ray crystallography has had on advancing an understanding of a class of enzymes that modify the bacterial cell wall. A substantial number of different bacterial amidase structures have been solved, mostly by X-ray crystallography. Comparison of these structures highlights conserved as well as divergent features. In combination with functional analyses, structural information on these enzymes has therefore proven to be a valuable template not only for understanding their mechanism of catalysis, but also for targeted interference with substrate binding. Copyright © 2015 Elsevier GmbH. All rights reserved.

Structure of Saturn's Rings from Cassini Diametric Radio Occultations

NASA Astrophysics Data System (ADS)

Marouf, E.; French, R.; Rappaport, N.; Kliore, A.; Flasar, M.; Nagy, A.; McGhee, C.; Schinder, P.; Anabtawi, A.; Asmar, S.; Barbinis, E.; Fleischman, D.; Goltz, G.; Johnston, D.; Rochblatt, D.; Thomson, F.; Wong, K.

2005-08-01

Cassini orbits around Saturn were designed to provide eight optimized radio occultation observations of Saturn's rings during summer, 2005. Three monochromatic radio signals (0.94, 3.6, and 13 cm-wavelength) were transmitted by Cassini through the rings and observed at multiple stations of the NASA Deep Space Network. A rich data set has been collected. Detailed structure of Ring B is revealed for the first time, including multi-feature dense ''core'' ˜ 6,000 km wide of normal optical depth > 4.3, a ˜ 5,500 km region of oscillations in optical depth ( ˜ 1.7 to ˜ 3.4) over characteristic radial scales of few hundred kilometers interior to the core, and a ˜ 5,000 km region exterior to the core of similar nature but smaller optical depth fluctuation ( ˜ 2.2 to ˜ 3.3). The innermost ˜ 7,000 km region is the thinnest (mean optical depth ˜ 1.2), and includes two unusually uniform regions and a prominent density wave. With few exceptions, the structure is nearly identical for the three radio signals (when detectable), indicating that Ring B is relatively devoid of centimeters and smaller size particles. The structure is largely circularly symmetric, except for radius > ˜ 116,600 km. In Ring A, numerous (> 40) density waves are clearly observed at multiple longitudes, different average background optical depth is observed among different occultations suggesting that the azimuthal asymmetry extends over most Ring A, and strong dependence of the observed structure on wavelength implies increase in the abundance of centimeter and smaller size particles with increasing radius. Multiple longitude observations of Ring C and the Cassini Division structure reveal remarkable variability of gaps and their embedded narrow eccentric ringlets, and a wake/wave like feature interior to the gap at ˜ 118,200 km (embedded moonlet?). Wavelength dependent structure of Ring C implies abundance of centimeter size particles everywhere and sorting by size within dense embedded features.

Employing Eigenvalue Ratios to Generate Prior Fracture-like Features for Stochastic Hydrogeophysical Characterization of a Fractured Aquifer System

NASA Astrophysics Data System (ADS)

Brewster, J.; Oware, E. K.

2017-12-01

Groundwater hosted in fractured rocks constitutes almost 65% of the principal aquifers in the US. The exploitation and contaminant management of fractured aquifers require fracture flow and transport modeling, which in turn requires a detailed understanding of the structure of the aquifer. The widely used equivalent porous medium approach to modeling fractured aquifer systems is inadequate to accurately predict fracture transport processes due to the averaging of the sharp lithological contrast between the matrix and the fractures. The potential of geophysical imaging (GI) to estimate spatially continuous subsurface profiles in a minimally invasive fashion is well proven. Conventional deterministic GI strategies, however, produce geologically unrealistic, smoothed-out results due to commonly enforced smoothing constraints. Stochastic GI of fractured aquifers is becoming increasing appealing due to its ability to recover realistic fracture features while providing multiple likely realizations that enable uncertainty assessment. Generating prior spatial features consistent with the expected target structures is crucial in stochastic imaging. We propose to utilize eigenvalue ratios to resolve the elongated fracture features expected in a fractured aquifer system. Eigenvalues capture the major and minor directions of variability in a region, which can be employed to evaluate shape descriptors, such as eccentricity (elongation) and orientation of features in the region. Eccentricity ranges from zero to one, representing a circularly sharped to a line feature, respectively. Here, we apply eigenvalue ratios to define a joint objective parameter consisting of eccentricity (shape) and direction terms to guide the generation of prior fracture-like features in some predefined principal directions for stochastic GI. Preliminary unconditional, synthetic experiments reveal the potential of the algorithm to simulate prior fracture-like features. We illustrate the strategy with a 2D, cross-borehole electrical resistivity tomography (ERT) in a fractured aquifer at the UB Environmental Geophysics Imaging Site, with tomograms validated with gamma and caliper logs obtained from the two ERT wells.

Vessel Classification in Cosmo-Skymed SAR Data Using Hierarchical Feature Selection

NASA Astrophysics Data System (ADS)

Makedonas, A.; Theoharatos, C.; Tsagaris, V.; Anastasopoulos, V.; Costicoglou, S.

2015-04-01

SAR based ship detection and classification are important elements of maritime monitoring applications. Recently, high-resolution SAR data have opened new possibilities to researchers for achieving improved classification results. In this work, a hierarchical vessel classification procedure is presented based on a robust feature extraction and selection scheme that utilizes scale, shape and texture features in a hierarchical way. Initially, different types of feature extraction algorithms are implemented in order to form the utilized feature pool, able to represent the structure, material, orientation and other vessel type characteristics. A two-stage hierarchical feature selection algorithm is utilized next in order to be able to discriminate effectively civilian vessels into three distinct types, in COSMO-SkyMed SAR images: cargos, small ships and tankers. In our analysis, scale and shape features are utilized in order to discriminate smaller types of vessels present in the available SAR data, or shape specific vessels. Then, the most informative texture and intensity features are incorporated in order to be able to better distinguish the civilian types with high accuracy. A feature selection procedure that utilizes heuristic measures based on features' statistical characteristics, followed by an exhaustive research with feature sets formed by the most qualified features is carried out, in order to discriminate the most appropriate combination of features for the final classification. In our analysis, five COSMO-SkyMed SAR data with 2.2m x 2.2m resolution were used to analyse the detailed characteristics of these types of ships. A total of 111 ships with available AIS data were used in the classification process. The experimental results show that this method has good performance in ship classification, with an overall accuracy reaching 83%. Further investigation of additional features and proper feature selection is currently in progress.

Exactly Solvable Models for Topological Phases of Matter

NASA Astrophysics Data System (ADS)

Tarantino, Nicolas Alessandro

Topological systems are characterized by some collection of features which remain unchanged under deformations of the Hamiltonian which leave the band gap open. The earliest examples of these were free fermion systems, allowing us to study the band structure to determine if a candidate material supports topological features. However, we can also ask the reversed question, i.e. Given a band gap, what topological features can be engineered? This classification problem proved to have numerous answers depending on which extra assumptions we allow, producing many candidate phases. While free fermion topological features could be classified by their band structures (culminating in the 10-fold way), strongly interacting systems defied this approach, and so classification outstripped the construction of even the most elementary Hamiltonians, leaving us with a number of phases which could exist, but do not have a single strongly interacting representative. The purpose of this thesis is to resolve this in certain cases by constructing commuting projector models (CPM), a class of exactly solvable models, for two types of topological phases, known as symmetry enriched topological (SET) order and fermionic symmetry protected topological (SPT) phases respectively. After introducing the background and history of commuting projector models, we will move on to the details of how these Hamiltonians are built. In the first case, we construct a CPM for a SET, showing how to encode the necessary group cohomology data into a lattice model. In the second, we construct a CPM for a fermionic SPT, and find that we must include a combinatorial representation of a spin structure to make the model consistent. While these two projects were independent, they are linked thematically by a technique known as decoration, where extra data is encoded onto simple models to generate exotic phases.

LINKING LUNG AIRWAY STRUCTURE TO PULMONARY FUNCTION VIA COMPOSITE BRIDGE REGRESSION

PubMed Central

Chen, Kun; Hoffman, Eric A.; Seetharaman, Indu; Jiao, Feiran; Lin, Ching-Long; Chan, Kung-Sik

2017-01-01

The human lung airway is a complex inverted tree-like structure. Detailed airway measurements can be extracted from MDCT-scanned lung images, such as segmental wall thickness, airway diameter, parent-child branch angles, etc. The wealth of lung airway data provides a unique opportunity for advancing our understanding of the fundamental structure-function relationships within the lung. An important problem is to construct and identify important lung airway features in normal subjects and connect these to standardized pulmonary function test results such as FEV1%. Among other things, the problem is complicated by the fact that a particular airway feature may be an important (relevant) predictor only when it pertains to segments of certain generations. Thus, the key is an efficient, consistent method for simultaneously conducting group selection (lung airway feature types) and within-group variable selection (airway generations), i.e., bi-level selection. Here we streamline a comprehensive procedure to process the lung airway data via imputation, normalization, transformation and groupwise principal component analysis, and then adopt a new composite penalized regression approach for conducting bi-level feature selection. As a prototype of composite penalization, the proposed composite bridge regression method is shown to admit an efficient algorithm, enjoy bi-level oracle properties, and outperform several existing methods. We analyze the MDCT lung image data from a cohort of 132 subjects with normal lung function. Our results show that, lung function in terms of FEV1% is promoted by having a less dense and more homogeneous lung comprising an airway whose segments enjoy more heterogeneity in wall thicknesses, larger mean diameters, lumen areas and branch angles. These data hold the potential of defining more accurately the “normal” subject population with borderline atypical lung functions that are clearly influenced by many genetic and environmental factors. PMID:28280520

Towards automatic musical instrument timbre recognition

NASA Astrophysics Data System (ADS)

Park, Tae Hong

This dissertation is comprised of two parts---focus on issues concerning research and development of an artificial system for automatic musical instrument timbre recognition and musical compositions. The technical part of the essay includes a detailed record of developed and implemented algorithms for feature extraction and pattern recognition. A review of existing literature introducing historical aspects surrounding timbre research, problems associated with a number of timbre definitions, and highlights of selected research activities that have had significant impact in this field are also included. The developed timbre recognition system follows a bottom-up, data-driven model that includes a pre-processing module, feature extraction module, and a RBF/EBF (Radial/Elliptical Basis Function) neural network-based pattern recognition module. 829 monophonic samples from 12 instruments have been chosen from the Peter Siedlaczek library (Best Service) and other samples from the Internet and personal collections. Significant emphasis has been put on feature extraction development and testing to achieve robust and consistent feature vectors that are eventually passed to the neural network module. In order to avoid a garbage-in-garbage-out (GIGO) trap and improve generality, extra care was taken in designing and testing the developed algorithms using various dynamics, different playing techniques, and a variety of pitches for each instrument with inclusion of attack and steady-state portions of a signal. Most of the research and development was conducted in Matlab. The compositional part of the essay includes brief introductions to "A d'Ess Are ," "Aboji," "48 13 N, 16 20 O," and "pH-SQ." A general outline pertaining to the ideas and concepts behind the architectural designs of the pieces including formal structures, time structures, orchestration methods, and pitch structures are also presented.

22q11.2 microduplication syndrome with congenital aural atresia: a family report.

PubMed

Boudewyns, An; van den Ende, Jenneke; Boiy, Tine; Van de Heyning, Paul; Declau, Frank

2012-06-01

22q11.2 microduplication syndrome is characterized by a large phenotypic variability including facial dysmorphism, developmental delay, and hearing loss. We describe a family in whom 5 of 11 children were affected by a unilateral or bilateral congenital aural atresia. Four of these 5 carried a 22q11.2 microduplication and had typical dysmorphic features. Computed tomography with 3-D reconstructions allowed for a detailed examination of the middle ear structures and classification of the atresia type. Audiometry revealed a moderately severe conductive hearing loss in accordance with the clinical and computed tomography findings. Detailed examination of the ear is warranted in patients with a 22q11.2 microduplication. When outer ear abnormalities are encountered, an additional workup including audiometry and computed tomography with 3-D reconstructions is required.

Bioaccessibility of nutrients and micronutrients from dispersed food systems: impact of the multiscale bulk and interfacial structures.

PubMed

Marze, Sébastien

2013-01-01

Many food systems are dispersed systems, that is, they possess at least two immiscible phases. This is generally due to the coexistence of domains with different physicochemical properties separated by many interfaces which control the apparent thermodynamic equilibrium. This feature was and is still largely studied to design pharmaceutical delivery systems. In food science, the recent intensification of in vitro digestion tests to complement the in vivo ones holds promises in the identification of the key parameters controlling the bioaccessibility of nutrients and micronutrients. In this review, we present the developments of in vitro digestion tests for dispersed food systems (mainly emulsions, dispersions and gels). We especially highlight the evidences detailing the roles of the constituting multiscale structures. In a perspective section, we show the potential of structured interfaces to allow controlled bioaccessibility.

Integrated Composite Analyzer (ICAN): Users and programmers manual

NASA Technical Reports Server (NTRS)

Murthy, P. L. N.; Chamis, C. C.

1986-01-01

The use of and relevant equations programmed in a computer code designed to carry out a comprehensive linear analysis of multilayered fiber composites is described. The analysis contains the essential features required to effectively design structural components made from fiber composites. The inputs to the code are constituent material properties, factors reflecting the fabrication process, and composite geometry. The code performs micromechanics, macromechanics, and laminate analysis, including the hygrothermal response of fiber composites. The code outputs are the various ply and composite properties, composite structural response, and composite stress analysis results with details on failure. The code is in Fortran IV and can be used efficiently as a package in complex structural analysis programs. The input-output format is described extensively through the use of a sample problem. The program listing is also included. The code manual consists of two parts.

Mesoporous benzene-silica hybrid materials with a different degree of order in the wall structure: an IR comparative study.

PubMed

Onida, Barbara; Camarota, Beatrice; Ugliengo, Piero; Goto, Yasutomo; Inagaki, Shinji; Garrone, Edoardo

2005-11-24

Recent joint IR and computational work (Onida et al. J. Phys. Chem B 2005) has allowed a detailed characterization of the isolated silanols at the surface of highly ordered benzene-silica hybrid material. In the present paper, a similar characterization is provided for a less ordered sample. The comparison permits the assignment of IR features to the interaction of silanols either with one another or with benzene rings of the structure. The extent of structural imperfections appears to be limited, for example, no more than pairs of interacting silanols are found, readily healed by thermal treatment. Evidence is also provided that probe molecules with simultaneous H-acceptor and H-donor properties (benzene, methylacetylene) may interact with both the acidic proton in silanols and the electronic cloud in the framework aromatic rings.

Entanglement structures in qubit systems

NASA Astrophysics Data System (ADS)

Rangamani, Mukund; Rota, Massimiliano

2015-09-01

Using measures of entanglement such as negativity and tangles we provide a detailed analysis of entanglement structures in pure states of non-interacting qubits. The motivation for this exercise primarily comes from holographic considerations, where entanglement is inextricably linked with the emergence of geometry. We use the qubit systems as toy models to probe the internal structure, and introduce some useful measures involving entanglement negativity to quantify general features of entanglement. In particular, our analysis focuses on various constraints on the pattern of entanglement which are known to be satisfied by holographic sates, such as the saturation of Araki-Lieb inequality (in certain circumstances), and the monogamy of mutual information. We argue that even systems as simple as few non-interacting qubits can be useful laboratories to explore how the emergence of the bulk geometry may be related to quantum information principles.

Sedimentary structures and stratal geometries at the foothills of Mount Sharp: their role in paleoenvironmental interpretation

NASA Astrophysics Data System (ADS)

Gupta, S.; Rubin, D. M.; Sumner, D. Y.; Grotzinger, J. P.; Lewis, K. W.; Stack, K.; Kah, L. C.; Banham, S.; Edgett, K. S.

2015-12-01

The Mars Science Laboratory Curiosity rover has been exploring sedimentary rocks at the foothills of Mount Sharp since August 2014. Robust interpretation of the paleoenvironmental contexts requires detailed facies analysis of these rocks including analysis and interpretation of sedimentary structures and sediment body geometries. Here, we describe some of the detailed sedimentary structures and sedimentary geometries observed by Curiosity between the Pahrump_Hills field site and its current location at Marias Pass. The Pahrump Hills sedimentary section comprises a succession dominated by finely laminated mudstones of the Murray formation that are interpreted to have been deposited in an ancient lake within Gale crater. Toward the top of the Pahump Hills succession, we observe the appearance of coarser-grained sandstones that are interstratified within the lacustrine mudstones. These sandstones that include Whale Rock and Newspaper Rock show lenticular geometries, and are pervasively cross-stratified. These features indicate that currents eroded shallow scours in the lake beds that were then infilled by deposition from migrating subaqueous dunes. The paleoenvironmental setting may represent either a gullied delta front setting or one in which lake level fall caused fluvial erosion and infilling of the shallow scours. Since leaving Pahrump_Hills, Curiosity has imaged extensive exposures of strata that are partly correlative with and stratigraphically overlie the uppermost part of the Pahrump section. Isolated cross-bedded sandstones and possible interstratified conglomerates beds occur within Murray formation mudstones. Capping sandstones with a likely variety of environmental contexts overlie mudstones. Where imaged in detail, sedimentary structures, such as trough-cross bedding and possible eolian pinstriping, provide constraints on plausible sedimentary processes and bounds on depositional setting.

The Crystal Structure Analysis of Group B Streptococcus Sortase C1: A Model for the ;Lid; Movement upon Substrate Binding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khare, Baldeep; Fu, Zheng-Qing; Huang, I-Hsiu

2012-02-07

A unique feature of the class-C-type sortases, enzymes essential for Gram-positive pilus biogenesis, is the presence of a flexible 'lid' anchored in the active site. However, the mechanistic details of the 'lid' displacement, suggested to be a critical prelude for enzyme catalysis, are not yet known. This is partly due to the absence of enzyme-substrate and enzyme-inhibitor complex crystal structures. We have recently described the crystal structures of the Streptococcus agalactiae SAG2603 V/R sortase SrtC1 in two space groups (type II and type III) and that of its 'lid' mutant and proposed a role of the 'lid' as a protectormore » of the active-site hydrophobic environment. Here, we report the crystal structures of SAG2603 V/R sortase C1 in a different space group (type I) and that of its complex with a small-molecule cysteine protease inhibitor. We observe that the catalytic Cys residue is covalently linked to the small-molecule inhibitor without lid displacement. However, the type I structure provides a view of the sortase SrtC1 lid displacement while having structural elements similar to a substrate sorting motif suitably positioned in the active site. We propose that these major conformational changes seen in the presence of a substrate mimic in the active site may represent universal features of class C sortase substrate recognition and enzyme activation.« less

Discrimination of Isomers of Released N- and O-Glycans Using Diagnostic Product Ions in Negative Ion PGC-LC-ESI-MS/MS

NASA Astrophysics Data System (ADS)

Ashwood, Christopher; Lin, Chi-Hung; Thaysen-Andersen, Morten; Packer, Nicolle H.

2018-03-01

Profiling cellular protein glycosylation is challenging due to the presence of highly similar glycan structures that play diverse roles in cellular physiology. As the anomericity and the exact linkage type of a single glycosidic bond can influence glycan function, there is a demand for improved and automated methods to confirm detailed structural features and to discriminate between structurally similar isomers, overcoming a significant bottleneck in the analysis of data generated by glycomics experiments. We used porous graphitized carbon-LC-ESI-MS/MS to separate and detect released N- and O-glycan isomers from mammalian model glycoproteins using negative mode resonance activation CID-MS/MS. By interrogating similar fragment spectra from closely related glycan isomers that differ only in arm position and sialyl linkage, product fragment ions for discrimination between these features were discovered. Using the Skyline software, at least two diagnostic fragment ions of high specificity were validated for automated discrimination of sialylation and arm position in N-glycan structures, and sialylation in O-glycan structures, complementing existing structural diagnostic ions. These diagnostic ions were shown to be useful for isomer discrimination using both linear and 3D ion trap mass spectrometers when analyzing complex glycan mixtures from cell lysates. Skyline was found to serve as a useful tool for automated assessment of glycan isomer discrimination. This platform-independent workflow can potentially be extended to automate the characterization and quantitation of other challenging glycan isomers. [Figure not available: see fulltext.

Ultrasonic guided wave interpretation for structural health inspections

NASA Astrophysics Data System (ADS)

Bingham, Jill Paisley

Structural Health Management (SHM) combines the use of onboard sensors with artificial intelligence algorithms to automatically identify and monitor structural health issues. A fully integrated approach to SHM systems demands an understanding of the sensor output relative to the structure, along with sophisticated prognostic systems that automatically draw conclusions about structural integrity issues. Ultrasonic guided wave methods allow us to examine the interaction of multimode signals within key structural components. Since they propagate relatively long distances within plate- and shell-like structures, guided waves allow inspection of greater areas with fewer sensors, making this technique attractive for a variety of applications. This dissertation describes the experimental development of automatic guided wave interpretation for three real world applications. Using the guided wave theories for idealized plates we have systematically developed techniques for identifying the mass loading of underwater limpet mines on US Navy ship hulls, characterizing type and bonding of protective coatings on large diameter pipelines, and detecting the thinning effects of corrosion on aluminum aircraft structural stringers. In each of these circumstances the signals received are too complex for interpretation without knowledge of the guided wave physics. We employ a signal processing technique called the Dynamic Wavelet Fingerprint Technique (DFWT) in order to render the guided wave mode information in two-dimensional binary images. The use of wavelets allows us to keep track of both time and scale features from the original signals. With simple image processing we have developed automatic extraction algorithms for features that correspond to the arrival times of the guided wave modes of interest for each of the applications. Due to the dispersive nature of the guided wave modes, the mode arrival times give details of the structure in the propagation path. For further understanding of how the guided wave modes propagate through the real structures, we have developed parallel processing, 3D elastic wave simulations using the finite integration technique (EFIT). This full field, numeric simulation technique easily examines models too complex for analytical solutions. We have developed the algorithm to handle built up 3D structures as well as layers with different material properties and surface detail. The simulations produce informative visualizations of the guided wave modes in the structures as well as the output from sensors placed in the simulation space to mimic the placement from experiment. Using the previously developed mode extraction algorithms we were then able to compare our 3D EFIT data to their experimental counterparts with consistency.

Computerized fracture critical and specialized bridge inspection program with NDE applications

NASA Astrophysics Data System (ADS)

Fish, Philip E.

1998-03-01

Wisconsin Department of Transportation implemented a Fracture Critical & Specialized Inspection Program in 1987. The program has a strong emphasis on Nondestructive Testing (NDT). The program is also completely computerized, using laptop computers to gather field data, digital cameras for pictures, and testing equipment with download features. Final inspection reports with detailed information can be delivered within days of the inspection. The program requires an experienced inspection team and qualified personnel. Individuals performing testing must be licensed ASNT (American Society for Nondestructive Testing) Level III and must be licensed Certified Weld Inspectors (American Welding Society). Several critical steps have been developed to assure that each inspection identifies all possible deficiencies that may be possible on a Fracture Critical or Unique Bridge. They include; review of all existing plans and maintenance history; identification of fracture critical members, identification of critical connection details, welds, & fatigue prone details, development of visual and NDE inspection plan; field inspection procedures; and a detailed formal report. The program has found several bridges with critical fatigue conditions which have resulted in replacement or major rehabilitation. In addition, remote monitoring systems have been installed on structures with serious cracking to monitor for changing conditions.

Plasma Radiation Source Development Program

DTIC Science & Technology

2006-03-01

shell mass distributions perform belter than thin shells. The dual plenum, double shell load has unique diagnostic features that enhance our...as implosion time increases. 13. SUBJECT TERMS Zpinch x-ray diagnostics Rayleigh-Taylor instability pulsed-power x-ray spectroscopy supersonic...feature permits some very useful diagnostics that shed light on critical details of the implosion process. See Section 3 for details. We have

Energy efficient engine fan component detailed design report

NASA Technical Reports Server (NTRS)

Halle, J. E.; Michael, C. J.

1981-01-01

The fan component which was designed for the energy efficient engine is an advanced high performance, single stage system and is based on technology advancements in aerodynamics and structure mechanics. Two fan components were designed, both meeting the integrated core/low spool engine efficiency goal of 84.5%. The primary configuration, envisioned for a future flight propulsion system, features a shroudless, hollow blade and offers a predicted efficiency of 87.3%. A more conventional blade was designed, as a back up, for the integrated core/low spool demonstrator engine. The alternate blade configuration has a predicted efficiency of 86.3% for the future flight propulsion system. Both fan configurations meet goals established for efficiency surge margin, structural integrity and durability.

Olive Component Oleuropein Promotes β-Cell Insulin Secretion and Protects β-Cells from Amylin Amyloid-Induced Cytotoxicity.

PubMed

Wu, Ling; Velander, Paul; Liu, Dongmin; Xu, Bin

2017-09-26

Oleuropein, a natural product derived from olive leaves, has reported anti-diabetic functions. However, detailed molecular mechanisms for how it affects β-cell functions remain poorly understood. Here, we present evidence that oleuropein promotes glucose-stimulated insulin secretion (GSIS) in β-cells. The effect is dose-dependent and stimulates the ERK/MAPK signaling pathway. We further demonstrated that oleuropein inhibits the cytotoxicity induced by amylin amyloids, a hallmark feature of type 2 diabetes. We demonstrated that these dual functions are structure-specific: we identified the 3-hydroxytyrosol moiety of oleuropein as the main functional entity responsible for amyloid inhibition, but the novel GSIS function requires the entire structure scaffold of the molecule.

Recent Advances in the Structural Mechanisms of DNA Glycosylases

PubMed Central

Brooks, Sonja C.; Adhikary, Suraj; Rubinson, Emily H.; Eichman, Brandt F.

2012-01-01

DNA glycosylases safeguard the genome by locating and excising a diverse array of aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the discovery 28 years ago that these enzymes employ a base flipping mechanism to trap their substrates, six different protein architectures have been identified to perform the same basic task. Work over the past several years has unraveled details for how the various DNA glycosylases survey DNA, detect damage within the duplex, select for the correct modification, and catalyze base excision. Here, we provide a broad overview of these latest advances in glycosylase mechanisms gleaned from structural enzymology, highlighting features common to all glycosylases as well as key differences that define their particular substrate specificities. PMID:23076011

Structural manipulation of the graphene/metal interface with Ar+ irradiation

NASA Astrophysics Data System (ADS)

Åhlgren, E. H.; Hämäläinen, S. K.; Lehtinen, O.; Liljeroth, P.; Kotakoski, J.

2013-10-01

Controlled defect creation is a prerequisite for the detailed study of disorder effects in materials. Here, we irradiate a graphene/Ir(111) interface with low-energy Ar+ to study the induced structural changes. Combining computer simulations and scanning-probe microscopy, we show that the resulting disorder manifests mainly in the forms of intercalated metal adatoms and vacancy-type defects in graphene. One prominent feature at higher irradiation energies (from 1 keV up) is the formation of linelike depressions, which consist of sequential graphene defects created by the ion channeling within the interface, much like a stone skipping on water. Lower energies result in simpler defects, down to 100 eV, where more than one defect in every three is a graphene single vacancy.

Large Eddy Simulation of Gravitational Effects on Transitional and Turbulent Gas-Jet Diffusion Flames

NASA Technical Reports Server (NTRS)

Givi, Peyman; Jaberi, Farhad A.

2001-01-01

The basic objective of this work is to assess the influence of gravity on "the compositional and the spatial structures" of transitional and turbulent diffusion flames via large eddy simulation (LES), and direct numerical simulation (DNS). The DNS is conducted for appraisal of the various closures employed in LES, and to study the effect of buoyancy on the small scale flow features. The LES is based on our "filtered mass density function"' (FMDF) model. The novelty of the methodology is that it allows for reliable simulations with inclusion of "realistic physics." It also allows for detailed analysis of the unsteady large scale flow evolution and compositional flame structure which is not usually possible via Reynolds averaged simulations.

Observations of low-frequency inertia-gravity waves in the lower stratosphere over Arecibo

NASA Technical Reports Server (NTRS)

Cornish, C. R.; Larsen, M. F.

1989-01-01

Results are presented of a detailed analysis of the horizontal wind data in the subtropical upper troposphere and lower stratosphere, obtained with the 430-MHz radar at Arecibo (Puerto Rico) in May 1982 and April 1983. Both sets of observations displayed a slowly varying anticyclonically rotating persistent structure in the wind field just above the tropopause, of the type that would be expected if the oscillations were associated with quasi-inertial period waves. The quasi-inertial period structure in the Arecibo observations appears to be typical of the results of a number of other studies, indicating that quasi-inertial period waves are a ubiquitous feature in the lower stratosphere, similar to what is observed in the oceans.

Oral features of a family with benign familial neutropenia.

PubMed

Porter, S R; Luker, J; Scully, C; Oakhill, A

1994-05-01

The oral features of three members of a family with familial benign neutropenia (a mother and two children) are detailed. Prepubertal periodontitis, oral ulceration, and angular stomatitis were the principal features.

Towards an affordable deep learning system: automated intervertebral disc detection in x-ray images

NASA Astrophysics Data System (ADS)

Sa, Ruhan; Owens, William; Wiegand, Raymond; Chaudhary, Vipin

2017-03-01

Adult Spinal Deformity is a prominent medical issue with about 68% of the elderly population suffering from the disease.1 Detailed biomechanical assessment is needed both in the presurgical planning of structural spinal deformity as well as in early functional biomechanical compensation in ambulatory spinal pain patients. When considering automation of this process, we have to look at photographic intervertebral disc detection technique as a way to produce a detailed model of the spine with appropriate measurements required to make efficient and accurate decisions on patient care. Deep convolutional neural network (CNN) has given remarkable results in object recognition tasks in recent years. However, massive training data, computational resources and long training time is needed for both training a deep network from scratch or finetuning a network. Using pretrained model as feature extractor has shown promising result for moderate sized medical data.2 However, most work have extracted features from the last layer and little has been explored in terms of the number of convolutional layers needed for best performance. In this work we trained Support Vector Machine (SVM) classifiers on different layers of CaffeNet3 features to show that deeper the better concept does not hold for task such as intervertebral disc detection. Furthermore, our experimental results show the potential of using very small training data, such as 15 annotated medical images in our experiment, to yield satisfactory classification performance with accuracy up to 97.2%.

GIRAF: a method for fast search and flexible alignment of ligand binding interfaces in proteins at atomic resolution

PubMed Central

Kinjo, Akira R.; Nakamura, Haruki

2012-01-01

Comparison and classification of protein structures are fundamental means to understand protein functions. Due to the computational difficulty and the ever-increasing amount of structural data, however, it is in general not feasible to perform exhaustive all-against-all structure comparisons necessary for comprehensive classifications. To efficiently handle such situations, we have previously proposed a method, now called GIRAF. We herein describe further improvements in the GIRAF protein structure search and alignment method. The GIRAF method achieves extremely efficient search of similar structures of ligand binding sites of proteins by exploiting database indexing of structural features of local coordinate frames. In addition, it produces refined atom-wise alignments by iterative applications of the Hungarian method to the bipartite graph defined for a pair of superimposed structures. By combining the refined alignments based on different local coordinate frames, it is made possible to align structures involving domain movements. We provide detailed accounts for the database design, the search and alignment algorithms as well as some benchmark results. PMID:27493524

'I love my work, but ... ': the 'best' and the 'worst' in nurse educators' working life in Finland.

PubMed

Harri, M

1996-06-01

The aim of this study was to investigate nurse educators' perceptions of the quality of their working life. Questionnaires were sent to 706 Finnish nurse educators and their spouses or other adult living with them. The results concerning the structured part of the questionnaire have been described in detail in an earlier paper (Harri 1995). This paper describes the data collected by means of semi-structured questions from 477 (68%) educators and 409 (58%) spouses) and open-ended questions (309 nurse educators and 167 spouses), analysed using content analysis. The seven categories that were identified as the best features of work were, in descending order of prevalence: students, freedom, challenges, teaching, miscellaneous, colleagues, and physical environment. Among the worst features of work, workload ranked first, followed by inadequacy of personal resources, administrative issues, changes, interpersonal relationships, miscellaneous, and physical environment. In the open-ended comments the nurse educators used 400 expressions to describe positive features of their working life, while they used 597 expressions to describe negative features. The spouses made 90 positive comments about the working life of their teacher spouse, and 425 negative comments. The importance of this kind of study was remarked on quite frequently both by nurse educators (22%) and their spouses (12%). The study provides important clues to understanding the present reality of nurse educators' working life. It is hoped that the findings of the study will help focus attention on ways of developing the quality of nurse educators' working life.

Topography of closed depressions, scarps, and grabens in the north Tharsis region of Mars: Implications for shallow crustal discontinuities and Graben formation

NASA Technical Reports Server (NTRS)

Davis, P. A.; Tanaka, Kenneth L.; Golombek, M. P.

1995-01-01

Using Viking Orbiter images, detailed photoclinometric profiles were obtained across 10 irregular depressions, 32 fretted fractures, 40 troughs and pits, 124 solitary scarps, and 370 simple grabens in the north Tharsis region of Mars. These data allow inferences to be made on the shallow crustal structure of this region. The frequency modes of measured scarp heights correspond with previous general thickness estimates of the heavily cratered and rigded plains units. The depths of the flat-floored irregular depressions (55-175 m), fretted fractures (85-890 m), and troughs and pits (60-1620 m) are also similar to scarp heights (thicknesses) of the geologic units in which these depressions occur, which suggests that the depths of these flat-floored features were controlled by erosional base levels created by lithologic contacts. Although the features have a similar age, both their depths and their observed local structural control increase in the order listed above, which suggests that the more advanced stages of associated fracturing facilitated the development of these depressions by increasing permeability. If a ground-ice zone is a factor in development of these features, as has been suggested, our observation that the depths of these features decrease with increasing latitude suggests that either the thickness of the ground-ice zone does not increase poleward or the depths of the depressions were controlled by the top of the ground-ice zone whose depth may decrease with latitude.

Characteristics of large three-dimensional heaps of particles produced by ballistic deposition from extended sources

NASA Astrophysics Data System (ADS)

Topic, Nikola; Gallas, Jason A. C.; Pöschel, Thorsten

2013-11-01

This paper reports a detailed numerical investigation of the geometrical and structural properties of three-dimensional heaps of particles. Our goal is the characterization of very large heaps produced by ballistic deposition from extended circular dropping areas. First, we provide an in-depth study of the formation of monodisperse heaps of particles. We find very large heaps to contain three new geometrical characteristics: they may display two external angles of repose, one internal angle of repose, and four distinct packing fraction (density) regions. Such features are found to be directly connected with the size of the dropping zone. We derive a differential equation describing the boundary of an unexpected triangular packing fraction zone formed under the dropping area. We investigate the impact that noise during the deposition has on the final heap structure. In addition, we perform two complementary experiments designed to test the robustness of the novel features found. The first experiment considers changes due to polydispersity. The second checks what happens when letting the extended dropping zone to become a point-like source of particles, the more common type of source.

Evaluating molecular cobalt complexes for the conversion of N2 to NH3.

PubMed

Del Castillo, Trevor J; Thompson, Niklas B; Suess, Daniel L M; Ung, Gaël; Peters, Jonas C

2015-10-05

Well-defined molecular catalysts for the reduction of N2 to NH3 with protons and electrons remain very rare despite decades of interest and are currently limited to systems featuring molybdenum or iron. This report details the synthesis of a molecular cobalt complex that generates superstoichiometric yields of NH3 (>200% NH3 per Co-N2 precursor) via the direct reduction of N2 with protons and electrons. While the NH3 yields reported herein are modest by comparison to those of previously described iron and molybdenum systems, they intimate that other metals are likely to be viable as molecular N2 reduction catalysts. Additionally, a comparison of the featured tris(phosphine)borane Co-N2 complex with structurally related Co-N2 and Fe-N2 species shows how remarkably sensitive the N2 reduction performance of potential precatalysts is. These studies enable consideration of the structural and electronic effects that are likely relevant to N2 conversion activity, including the π basicity, charge state, and geometric flexibility.

Infrared Surveys of Hawaiian Volcanoes: Aerial surveys with infrared imaging radiometer depict volcanic thermal patterns and structural features.

PubMed

Fisher, W A; Moxham, R M; Polcyn, F; Landis, G H

1964-11-06

Aerial infrared-sensor surveys of Kilauea volcano have depicted the areal extent and the relative intensity of abnormal thermal features in the caldera area of the volcano and along its associated rift zones. Many of these anomalies show correlation with visible steaming and reflect convective transfer of heat to the surface from subterranean sources. Structural details of the volcano, some not evident from surface observation, are also delineated by their thermal abnormalities. Several changes were observed in the patterns of infrared emission during the period of study; two such changes show correlation in location with subsequent eruptions, but the cause-and-effect relationship is uncertain. Thermal anomalies were also observed on the southwest flank of Mauna Loa; images of other volcanoes on the island of Hawaii, and of Haleakala on the island of Maui, revealed no thermal abnormalities. Approximately 25 large springs issuing into the ocean around the periphery of Hawaii have been detected. Infrared emission varies widely with surface texture and composition, suggesting that similar observations may have value for estimating surface conditions on the moon or planets.

Divergent evolution in fluviokarst landscapes of central Kentucky

USGS Publications Warehouse

Phillips, J.D.; Martin, L.L.; Nordberg, V.G.; Andrews, W.A.

2004-01-01

Central Kentucky is characterized by a mixture of karst and fluvial features, typically manifested as mosaic of karst-rich/ channel-poor (KRCP) and channel-rich/karst-poor (CRKP) environments. At the regional scale the location and distribution of KRCP and CRKP areas are not always systematically related to structural, lithological, topographic, or other controls. This study examines the relationship of KRCP and CRKP zones along the Kentucky River gorge area, where rapid incision in the last 1??5 million years has lowered local base levels and modified slopes on the edge of the inner bluegrass plateau. At the scale of detailed field mapping on foot within a 4 km2 area, the development of karst and fluvial features is controlled by highly localized structural and topographic constraints, and can be related to slope changes associated with retreat of the Kentucky River gorge escarpment. A conceptual model of karst/fluvial transitions is presented, which suggests that minor, localized variations are sufficient to trigger a karst-fluvial or fluvial-karst switch when critical slope thresholds are crossed. ?? 2004 John Wiley and Sons, Ltd.

Distinction of Neurons, Glia and Endothelial Cells in the Cerebral Cortex: An Algorithm Based on Cytological Features

PubMed Central

García-Cabezas, Miguel Á.; John, Yohan J.; Barbas, Helen; Zikopoulos, Basilis

2016-01-01

The estimation of the number or density of neurons and types of glial cells and their relative proportions in different brain areas are at the core of rigorous quantitative neuroanatomical studies. Unfortunately, the lack of detailed, updated, systematic and well-illustrated descriptions of the cytology of neurons and glial cell types, especially in the primate brain, makes such studies especially demanding, often limiting their scope and broad use. Here, following an extensive analysis of histological materials and the review of current and classical literature, we compile a list of precise morphological criteria that can facilitate and standardize identification of cells in stained sections examined under the microscope. We describe systematically and in detail the cytological features of neurons and glial cell types in the cerebral cortex of the macaque monkey and the human using semithin and thick sections stained for Nissl. We used this classical staining technique because it labels all cells in the brain in distinct ways. In addition, we corroborate key distinguishing characteristics of different cell types in sections immunolabeled for specific markers counterstained for Nissl and in ultrathin sections processed for electron microscopy. Finally, we summarize the core features that distinguish each cell type in easy-to-use tables and sketches, and structure these key features in an algorithm that can be used to systematically distinguish cellular types in the cerebral cortex. Moreover, we report high inter-observer algorithm reliability, which is a crucial test for obtaining consistent and reproducible cell counts in unbiased stereological studies. This protocol establishes a consistent framework that can be used to reliably identify and quantify cells in the cerebral cortex of primates as well as other mammalian species in health and disease. PMID:27847469

Reporting of methodological features in observational studies of pre-harvest food safety.

PubMed

Sargeant, Jan M; O'Connor, Annette M; Renter, David G; Kelton, David F; Snedeker, Kate; Wisener, Lee V; Leonard, Erin K; Guthrie, Alessia D; Faires, Meredith

2011-02-01

Observational studies in pre-harvest food safety may be useful for identifying risk factors and for evaluating potential mitigation strategies to reduce foodborne pathogens. However, there are no structured reporting guidelines for these types of study designs in livestock species. Our objective was to evaluate the reporting of observational studies in the pre-harvest food safety literature using guidelines modified from the human healthcare literature. We identified 100 pre-harvest food safety studies published between 1999 and 2009. Each study was evaluated independently by two reviewers using a structured checklist. Of the 38 studies that explicitly stated the observational study design, 27 were described as cross-sectional studies, eight as case-control studies, and three as cohort studies. Study features reported in over 75% of the selected studies included: description of the geographic location of the studies, definitions and sources of data for outcomes, organizational level and source of data for independent variables, description of statistical methods and results, number of herds enrolled in the study and included in the analysis, and sources of study funding. However, other features were not consistently reported, including details related to eligibility criteria for groups (such as barn, room, or pen) and individuals, numbers of groups and individuals included in various stages of the study, identification of primary outcomes, the distinction between putative risk factors and confounding variables, the identification of a primary exposure variable, the referent level for evaluation of categorical variable associations, methods of controlling confounding variables and missing variables, model fit, details of subset analysis, demographic information at the sampling unit level, and generalizability of the study results. Improvement in reporting of observational studies of pre-harvest food safety will aid research readers and reviewers in interpreting and evaluating the results of such studies. Copyright © 2010 Elsevier B.V. All rights reserved.

PolySac3DB: an annotated data base of 3 dimensional structures of polysaccharides.

PubMed

Sarkar, Anita; Pérez, Serge

2012-11-14

Polysaccharides are ubiquitously present in the living world. Their structural versatility makes them important and interesting components in numerous biological and technological processes ranging from structural stabilization to a variety of immunologically important molecular recognition events. The knowledge of polysaccharide three-dimensional (3D) structure is important in studying carbohydrate-mediated host-pathogen interactions, interactions with other bio-macromolecules, drug design and vaccine development as well as material science applications or production of bio-ethanol. PolySac3DB is an annotated database that contains the 3D structural information of 157 polysaccharide entries that have been collected from an extensive screening of scientific literature. They have been systematically organized using standard names in the field of carbohydrate research into 18 categories representing polysaccharide families. Structure-related information includes the saccharides making up the repeat unit(s) and their glycosidic linkages, the expanded 3D representation of the repeat unit, unit cell dimensions and space group, helix type, diffraction diagram(s) (when applicable), experimental and/or simulation methods used for structure description, link to the abstract of the publication, reference and the atomic coordinate files for visualization and download. The database is accompanied by a user-friendly graphical user interface (GUI). It features interactive displays of polysaccharide structures and customized search options for beginners and experts, respectively. The site also serves as an information portal for polysaccharide structure determination techniques. The web-interface also references external links where other carbohydrate-related resources are available. PolySac3DB is established to maintain information on the detailed 3D structures of polysaccharides. All the data and features are available via the web-interface utilizing the search engine and can be accessed at http://polysac3db.cermav.cnrs.fr.

Structure-based classification and ontology in chemistry

PubMed Central

2012-01-01

Background Recent years have seen an explosion in the availability of data in the chemistry domain. With this information explosion, however, retrieving relevant results from the available information, and organising those results, become even harder problems. Computational processing is essential to filter and organise the available resources so as to better facilitate the work of scientists. Ontologies encode expert domain knowledge in a hierarchically organised machine-processable format. One such ontology for the chemical domain is ChEBI. ChEBI provides a classification of chemicals based on their structural features and a role or activity-based classification. An example of a structure-based class is 'pentacyclic compound' (compounds containing five-ring structures), while an example of a role-based class is 'analgesic', since many different chemicals can act as analgesics without sharing structural features. Structure-based classification in chemistry exploits elegant regularities and symmetries in the underlying chemical domain. As yet, there has been neither a systematic analysis of the types of structural classification in use in chemistry nor a comparison to the capabilities of available technologies. Results We analyze the different categories of structural classes in chemistry, presenting a list of patterns for features found in class definitions. We compare these patterns of class definition to tools which allow for automation of hierarchy construction within cheminformatics and within logic-based ontology technology, going into detail in the latter case with respect to the expressive capabilities of the Web Ontology Language and recent extensions for modelling structured objects. Finally we discuss the relationships and interactions between cheminformatics approaches and logic-based approaches. Conclusion Systems that perform intelligent reasoning tasks on chemistry data require a diverse set of underlying computational utilities including algorithmic, statistical and logic-based tools. For the task of automatic structure-based classification of chemical entities, essential to managing the vast swathes of chemical data being brought online, systems which are capable of hybrid reasoning combining several different approaches are crucial. We provide a thorough review of the available tools and methodologies, and identify areas of open research. PMID:22480202

RNA-TVcurve: a Web server for RNA secondary structure comparison based on a multi-scale similarity of its triple vector curve representation.

PubMed

Li, Ying; Shi, Xiaohu; Liang, Yanchun; Xie, Juan; Zhang, Yu; Ma, Qin

2017-01-21

RNAs have been found to carry diverse functionalities in nature. Inferring the similarity between two given RNAs is a fundamental step to understand and interpret their functional relationship. The majority of functional RNAs show conserved secondary structures, rather than sequence conservation. Those algorithms relying on sequence-based features usually have limitations in their prediction performance. Hence, integrating RNA structure features is very critical for RNA analysis. Existing algorithms mainly fall into two categories: alignment-based and alignment-free. The alignment-free algorithms of RNA comparison usually have lower time complexity than alignment-based algorithms. An alignment-free RNA comparison algorithm was proposed, in which novel numerical representations RNA-TVcurve (triple vector curve representation) of RNA sequence and corresponding secondary structure features are provided. Then a multi-scale similarity score of two given RNAs was designed based on wavelet decomposition of their numerical representation. In support of RNA mutation and phylogenetic analysis, a web server (RNA-TVcurve) was designed based on this alignment-free RNA comparison algorithm. It provides three functional modules: 1) visualization of numerical representation of RNA secondary structure; 2) detection of single-point mutation based on secondary structure; and 3) comparison of pairwise and multiple RNA secondary structures. The inputs of the web server require RNA primary sequences, while corresponding secondary structures are optional. For the primary sequences alone, the web server can compute the secondary structures using free energy minimization algorithm in terms of RNAfold tool from Vienna RNA package. RNA-TVcurve is the first integrated web server, based on an alignment-free method, to deliver a suite of RNA analysis functions, including visualization, mutation analysis and multiple RNAs structure comparison. The comparison results with two popular RNA comparison tools, RNApdist and RNAdistance, showcased that RNA-TVcurve can efficiently capture subtle relationships among RNAs for mutation detection and non-coding RNA classification. All the relevant results were shown in an intuitive graphical manner, and can be freely downloaded from this server. RNA-TVcurve, along with test examples and detailed documents, are available at: http://ml.jlu.edu.cn/tvcurve/ .

High-pressure crystal structures of an insensitive energetic crystal: 1,1-diamino-2,2-dinitroethene

DOE PAGES

Dreger, Zbigniew A.; Stash, Adam I.; Yu, Zhi -Gang; ...

2015-12-03

Understanding the insensitivity/stability of insensitive high explosive crystals requires detailed structural information at high pressures and high temperatures of interest. Synchrotron single crystal x-ray diffraction experiments were used to determine the high-pressure structures of 1,1-diamino-2,2-dinitroethene (FOX-7), a prototypical insensitive high explosive. The phase transition around 4.5 GPa was investigated and the structures were determined at 4.27 GPa (α’-phase) and 5.9 GPa (ε-phase). The α’-phase (monoclinic, P2 1/ n), structurally indistinguishable from the ambient α-phase, transforms to the new ε-phase (triclinic, P1). The most notable features of the ε-phase, compared to the α’-phase, are: formation of planar layers and flattening ofmore » molecules. Density functional theory (DFT-D2) calculations complemented the experimental results. Furthermore, the results presented here are important for understanding the molecular and crystalline attributes governing the high-pressure insensitivity/stability of insensitive high explosive crystals.« less

Structural Image Analysis of the Brain in Neuropsychology Using Magnetic Resonance Imaging (MRI) Techniques.

PubMed

Bigler, Erin D

2015-09-01

Magnetic resonance imaging (MRI) of the brain provides exceptional image quality for visualization and neuroanatomical classification of brain structure. A variety of image analysis techniques provide both qualitative as well as quantitative methods to relate brain structure with neuropsychological outcome and are reviewed herein. Of particular importance are more automated methods that permit analysis of a broad spectrum of anatomical measures including volume, thickness and shape. The challenge for neuropsychology is which metric to use, for which disorder and the timing of when image analysis methods are applied to assess brain structure and pathology. A basic overview is provided as to the anatomical and pathoanatomical relations of different MRI sequences in assessing normal and abnormal findings. Some interpretive guidelines are offered including factors related to similarity and symmetry of typical brain development along with size-normalcy features of brain anatomy related to function. The review concludes with a detailed example of various quantitative techniques applied to analyzing brain structure for neuropsychological outcome studies in traumatic brain injury.

High-pressure crystal structures of an insensitive energetic crystal: 1,1-diamino-2,2-dinitroethene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dreger, Zbigniew A.; Stash, Adam I.; Yu, Zhi -Gang

Understanding the insensitivity/stability of insensitive high explosive crystals requires detailed structural information at high pressures and high temperatures of interest. Synchrotron single crystal x-ray diffraction experiments were used to determine the high-pressure structures of 1,1-diamino-2,2-dinitroethene (FOX-7), a prototypical insensitive high explosive. The phase transition around 4.5 GPa was investigated and the structures were determined at 4.27 GPa (α’-phase) and 5.9 GPa (ε-phase). The α’-phase (monoclinic, P2 1/ n), structurally indistinguishable from the ambient α-phase, transforms to the new ε-phase (triclinic, P1). The most notable features of the ε-phase, compared to the α’-phase, are: formation of planar layers and flattening ofmore » molecules. Density functional theory (DFT-D2) calculations complemented the experimental results. Furthermore, the results presented here are important for understanding the molecular and crystalline attributes governing the high-pressure insensitivity/stability of insensitive high explosive crystals.« less

A Consensus Model of Human Apolipoprotein A-I in its Monomeric and Lipid-free State

PubMed Central

Melchior, John T.; Walker, Ryan G.; Cooke, Allison L.; Morris, Jamie; Castleberry, Mark; Thompson, Thomas B.; Jones, Martin K.; Song, Hyun D.; Rye, Kerry-Anne; Oda, Mike N.; Sorci-Thomas, Mary G.; Thomas, Michael J.; Heinecke, Jay W.; Mei, Xiaohu; Atkinson, David; Segrest, Jere P.; Lund-Katz, Sissel; Phillips, Michael C.; Davidson, W. Sean

2017-01-01

Apolipoprotein (apo)A-I is an organizing scaffold protein that is critical to high density lipoprotein (HDL) structure and metabolism, likely mediating many of its cardioprotective properties. However, HDL biogenesis is poorly understood as lipid-free apoA-I has been notoriously resistant to high resolution structural study. Published models from low resolution techniques share certain features but vary considerably in shape and secondary structure. To tackle this central issue in lipoprotein biology, we assembled an unprecedented team of lipoprotein structural biologists and set out to build a consensus model of monomeric lipid-free human apoA-I. Combining novel and published cross-link constraints, small angle X-ray scattering (SAXS), hydrogen-deuterium exchange (H-DX) and crystallography data, we propose a time averaged model consistent with much of the experimental data published over the last 40 years. The model provides a long sought platform for understanding and testing details of HDL biogenesis, structure and function. PMID:29131142

Linear structures on the small inner satellites of Saturn

NASA Technical Reports Server (NTRS)

Stooke, Philip J.

1993-01-01

Shape modelling methods developed for non-spherical worlds were applied to four satellites of Saturn: Prometheus, Pandora, Janus, and Epimetheus. This results in the first detailed shaded relief maps of their surfaces. Ridges and valleys are described with their implications for satellite history and asteroid 951 Gaspra. They probably result from fracturing during break-up of parent bodies and/or later large impacts. Prometheus and perhaps Gaspra may be coated with debris from parent body fragmentation as well as more recent regolith. These four satellites are covered by relatively few useful images, so the shapes are imperfectly known and positions of features on maps may be wrong by up to a few tens of degrees in some areas (worst where a feature is seen only near a limb). Nevertheless, these shape models are more useful than the previous triaxial ellipsoid models.

A High Resolution Spectroscopic Observation of CAL 83 with XMM-Newton/RGS

NASA Technical Reports Server (NTRS)

Paerels, Frits; Rasmussen, Andrew P.; Hartmann, H. W.; Heise, J.; Brinkman, A. C.; deVries, C. P.; denHerder, J.-W.

2000-01-01

We present the first high resolution photospheric X-ray spectrum of a Supersoft X-ray Source, the famous CAL 83 in the Large Magellanic Cloud. The spectrum was obtained with the Reflection Grating Spectrometer on XMM-Newton during the Calibration/Performance Verification phase of the observatory. The spectrum covers the range 20-40 A at an approximately constant resolution of 0.05 A, and shows very significant, intricate detail, that is very sensitive to the physical properties of the object. We present the results of an initial investigation of the spectrum, from which we draw the conclusion that the spectral structure is probably dominated by numerous absorption features due to transitions in the Gshells of the mid-2 elements and the M-shell of Fe, in addition to a few strong K-shell features due to CNO.

Gamble While You Gamble: Electronic Games in Ontario Charitable Gaming Centres.

PubMed

Harrigan, Kevin; Brown, Dan; MacLaren, Vance

Electronic Bingo games have recently appeared in Ontario Charitable Gaming Centres. Here we summarize the characteristics of this novel form of electronic gambling, and give a detailed characterization of one game. We contend that these games have structural characteristics that make them similar to modern Electronic Gaming Machines (EGMs) that feature multiline slots games. These features include a fast and continuous gaming experience, with player adjustable win size and reinforcement rate, a high frequency of losses disguised as wins, and highly salient near misses. Some of these games also have bonus rounds and provide players with a list of recent wins. We conclude that provincial and state gaming authorities should be aware that the placement of Bingo EGMs in existing Bingo facilities may increase problem gambling among an already well-established community of Bingo enthusiasts.

DIBS: a repository of disordered binding sites mediating interactions with ordered proteins.

PubMed

Schad, Eva; Fichó, Erzsébet; Pancsa, Rita; Simon, István; Dosztányi, Zsuzsanna; Mészáros, Bálint

2018-02-01

Intrinsically Disordered Proteins (IDPs) mediate crucial protein-protein interactions, most notably in signaling and regulation. As their importance is increasingly recognized, the detailed analyses of specific IDP interactions opened up new opportunities for therapeutic targeting. Yet, large scale information about IDP-mediated interactions in structural and functional details are lacking, hindering the understanding of the mechanisms underlying this distinct binding mode. Here, we present DIBS, the first comprehensive, curated collection of complexes between IDPs and ordered proteins. DIBS not only describes by far the highest number of cases, it also provides the dissociation constants of their interactions, as well as the description of potential post-translational modifications modulating the binding strength and linear motifs involved in the binding. Together with the wide range of structural and functional annotations, DIBS will provide the cornerstone for structural and functional studies of IDP complexes. DIBS is freely accessible at http://dibs.enzim.ttk.mta.hu/. The DIBS application is hosted by Apache web server and was implemented in PHP. To enrich querying features and to enhance backend performance a MySQL database was also created. dosztanyi@caesar.elte.hu or bmeszaros@caesar.elte.hu. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press.

BlastNeuron for Automated Comparison, Retrieval and Clustering of 3D Neuron Morphologies.

PubMed

Wan, Yinan; Long, Fuhui; Qu, Lei; Xiao, Hang; Hawrylycz, Michael; Myers, Eugene W; Peng, Hanchuan

2015-10-01

Characterizing the identity and types of neurons in the brain, as well as their associated function, requires a means of quantifying and comparing 3D neuron morphology. Presently, neuron comparison methods are based on statistics from neuronal morphology such as size and number of branches, which are not fully suitable for detecting local similarities and differences in the detailed structure. We developed BlastNeuron to compare neurons in terms of their global appearance, detailed arborization patterns, and topological similarity. BlastNeuron first compares and clusters 3D neuron reconstructions based on global morphology features and moment invariants, independent of their orientations, sizes, level of reconstruction and other variations. Subsequently, BlastNeuron performs local alignment between any pair of retrieved neurons via a tree-topology driven dynamic programming method. A 3D correspondence map can thus be generated at the resolution of single reconstruction nodes. We applied BlastNeuron to three datasets: (1) 10,000+ neuron reconstructions from a public morphology database, (2) 681 newly and manually reconstructed neurons, and (3) neurons reconstructions produced using several independent reconstruction methods. Our approach was able to accurately and efficiently retrieve morphologically and functionally similar neuron structures from large morphology database, identify the local common structures, and find clusters of neurons that share similarities in both morphology and molecular profiles.

Recovering Long-wavelength Velocity Models using Spectrogram Inversion with Single- and Multi-frequency Components

NASA Astrophysics Data System (ADS)

Ha, J.; Chung, W.; Shin, S.

2015-12-01

Many waveform inversion algorithms have been proposed in order to construct subsurface velocity structures from seismic data sets. These algorithms have suffered from computational burden, local minima problems, and the lack of low-frequency components. Computational efficiency can be improved by the application of back-propagation techniques and advances in computing hardware. In addition, waveform inversion algorithms, for obtaining long-wavelength velocity models, could avoid both the local minima problem and the effect of the lack of low-frequency components in seismic data. In this study, we proposed spectrogram inversion as a technique for recovering long-wavelength velocity models. In spectrogram inversion, decomposed frequency components from spectrograms of traces, in the observed and calculated data, are utilized to generate traces with reproduced low-frequency components. Moreover, since each decomposed component can reveal the different characteristics of a subsurface structure, several frequency components were utilized to analyze the velocity features in the subsurface. We performed the spectrogram inversion using a modified SEG/SEGE salt A-A' line. Numerical results demonstrate that spectrogram inversion could also recover the long-wavelength velocity features. However, inversion results varied according to the frequency components utilized. Based on the results of inversion using a decomposed single-frequency component, we noticed that robust inversion results are obtained when a dominant frequency component of the spectrogram was utilized. In addition, detailed information on recovered long-wavelength velocity models was obtained using a multi-frequency component combined with single-frequency components. Numerical examples indicate that various detailed analyses of long-wavelength velocity models can be carried out utilizing several frequency components.

Autobiographical Planning and the Brain: Activation and Its Modulation by Qualitative Features.

PubMed

Spreng, R Nathan; Gerlach, Kathy D; Turner, Gary R; Schacter, Daniel L

2015-11-01

To engage in purposeful behavior, it is important to make plans, which organize subsequent actions. Most studies of planning involve "look-ahead" puzzle tasks that are unrelated to personal goals. We developed a task to assess autobiographical planning, which involves the formulation of personal plans in response to real-world goals, and examined autobiographical planning in 63 adults during fMRI scanning. Autobiographical planning was found to engage the default network, including medial-temporal lobe and midline structures, and executive control regions in lateral pFC and parietal cortex and caudate. To examine how specific qualitative features of autobiographical plans modulate neural activity, we performed parametric modulation analyses. Ratings of plan detail, novelty, temporal distance, ease of plan formulation, difficulty in goal completion, and confidence in goal accomplishment were used as covariates in six hierarchical linear regression models. This modeling procedure removed shared variance among the ratings, allowing us to determine the independent relationship between ratings of interest and trial-wise BOLD signal. We found that specific autobiographical planning, describing a detailed, achievable, and actionable planning process for attaining a clearly envisioned future, recruited both default and frontoparietal brain regions. In contrast, abstract autobiographical planning, plans that were constructed from more generalized semantic or affective representations of a less tangible and distant future, involved interactions among default, sensory perceptual, and limbic brain structures. Specific qualities of autobiographical plans are important predictors of default and frontoparietal control network engagement during plan formation and reflect the contribution of mnemonic and executive control processes to autobiographical planning.

Hdr Imaging for Feature Detection on Detailed Architectural Scenes

NASA Astrophysics Data System (ADS)

Kontogianni, G.; Stathopoulou, E. K.; Georgopoulos, A.; Doulamis, A.

2015-02-01

3D reconstruction relies on accurate detection, extraction, description and matching of image features. This is even truer for complex architectural scenes that pose needs for 3D models of high quality, without any loss of detail in geometry or color. Illumination conditions influence the radiometric quality of images, as standard sensors cannot depict properly a wide range of intensities in the same scene. Indeed, overexposed or underexposed pixels cause irreplaceable information loss and degrade digital representation. Images taken under extreme lighting environments may be thus prohibitive for feature detection/extraction and consequently for matching and 3D reconstruction. High Dynamic Range (HDR) images could be helpful for these operators because they broaden the limits of illumination range that Standard or Low Dynamic Range (SDR/LDR) images can capture and increase in this way the amount of details contained in the image. Experimental results of this study prove this assumption as they examine state of the art feature detectors applied both on standard dynamic range and HDR images.

An edge-directed interpolation method for fetal spine MR images.

PubMed

Yu, Shaode; Zhang, Rui; Wu, Shibin; Hu, Jiani; Xie, Yaoqin

2013-10-10

Fetal spinal magnetic resonance imaging (MRI) is a prenatal routine for proper assessment of fetus development, especially when suspected spinal malformations occur while ultrasound fails to provide details. Limited by hardware, fetal spine MR images suffer from its low resolution.High-resolution MR images can directly enhance readability and improve diagnosis accuracy. Image interpolation for higher resolution is required in clinical situations, while many methods fail to preserve edge structures. Edge carries heavy structural messages of objects in visual scenes for doctors to detect suspicions, classify malformations and make correct diagnosis. Effective interpolation with well-preserved edge structures is still challenging. In this paper, we propose an edge-directed interpolation (EDI) method and apply it on a group of fetal spine MR images to evaluate its feasibility and performance. This method takes edge messages from Canny edge detector to guide further pixel modification. First, low-resolution (LR) images of fetal spine are interpolated into high-resolution (HR) images with targeted factor by bi-linear method. Then edge information from LR and HR images is put into a twofold strategy to sharpen or soften edge structures. Finally a HR image with well-preserved edge structures is generated. The HR images obtained from proposed method are validated and compared with that from other four EDI methods. Performances are evaluated from six metrics, and subjective analysis of visual quality is based on regions of interest (ROI). All these five EDI methods are able to generate HR images with enriched details. From quantitative analysis of six metrics, the proposed method outperforms the other four from signal-to-noise ratio (SNR), peak signal-to-noise ratio (PSNR), structure similarity index (SSIM), feature similarity index (FSIM) and mutual information (MI) with seconds-level time consumptions (TC). Visual analysis of ROI shows that the proposed method maintains better consistency in edge structures with the original images. The proposed method classifies edge orientations into four categories and well preserves structures. It generates convincing HR images with fine details and is suitable in real-time situations. Iterative curvature-based interpolation (ICBI) method may result in crisper edges, while the other three methods are sensitive to noise and artifacts.

DataRocket: Interactive Visualisation of Data Structures

NASA Astrophysics Data System (ADS)

Parkes, Steve; Ramsay, Craig

2010-08-01

CodeRocket is a software engineering tool that provides cognitive support to the software engineer for reasoning about a method or procedure and for documenting the resulting code [1]. DataRocket is a software engineering tool designed to support visualisation and reasoning about program data structures. DataRocket is part of the CodeRocket family of software tools developed by Rapid Quality Systems [2] a spin-out company from the Space Technology Centre at the University of Dundee. CodeRocket and DataRocket integrate seamlessly with existing architectural design and coding tools and provide extensive documentation with little or no effort on behalf of the software engineer. Comprehensive, abstract, detailed design documentation is available early on in a project so that it can be used for design reviews with project managers and non expert stakeholders. Code and documentation remain fully synchronised even when changes are implemented in the code without reference to the existing documentation. At the end of a project the press of a button suffices to produce the detailed design document. Existing legacy code can be easily imported into CodeRocket and DataRocket to reverse engineer detailed design documentation making legacy code more manageable and adding substantially to its value. This paper introduces CodeRocket. It then explains the rationale for DataRocket and describes the key features of this new tool. Finally the major benefits of DataRocket for different stakeholders are considered.

Neonatal Atlas Construction Using Sparse Representation

PubMed Central

Shi, Feng; Wang, Li; Wu, Guorong; Li, Gang; Gilmore, John H.; Lin, Weili; Shen, Dinggang

2014-01-01

Atlas construction generally includes first an image registration step to normalize all images into a common space and then an atlas building step to fuse the information from all the aligned images. Although numerous atlas construction studies have been performed to improve the accuracy of the image registration step, unweighted or simply weighted average is often used in the atlas building step. In this article, we propose a novel patch-based sparse representation method for atlas construction after all images have been registered into the common space. By taking advantage of local sparse representation, more anatomical details can be recovered in the built atlas. To make the anatomical structures spatially smooth in the atlas, the anatomical feature constraints on group structure of representations and also the overlapping of neighboring patches are imposed to ensure the anatomical consistency between neighboring patches. The proposed method has been applied to 73 neonatal MR images with poor spatial resolution and low tissue contrast, for constructing a neonatal brain atlas with sharp anatomical details. Experimental results demonstrate that the proposed method can significantly enhance the quality of the constructed atlas by discovering more anatomical details especially in the highly convoluted cortical regions. The resulting atlas demonstrates superior performance of our atlas when applied to spatially normalizing three different neonatal datasets, compared with other start-of-the-art neonatal brain atlases. PMID:24638883

Insights into DNA-mediated interparticle interactions from a coarse-grained model

NASA Astrophysics Data System (ADS)

Ding, Yajun; Mittal, Jeetain

2014-11-01

DNA-functionalized particles have great potential for the design of complex self-assembled materials. The major hurdle in realizing crystal structures from DNA-functionalized particles is expected to be kinetic barriers that trap the system in metastable amorphous states. Therefore, it is vital to explore the molecular details of particle assembly processes in order to understand the underlying mechanisms. Molecular simulations based on coarse-grained models can provide a convenient route to explore these details. Most of the currently available coarse-grained models of DNA-functionalized particles ignore key chemical and structural details of DNA behavior. These models therefore are limited in scope for studying experimental phenomena. In this paper, we present a new coarse-grained model of DNA-functionalized particles which incorporates some of the desired features of DNA behavior. The coarse-grained DNA model used here provides explicit DNA representation (at the nucleotide level) and complementary interactions between Watson-Crick base pairs, which lead to the formation of single-stranded hairpin and double-stranded DNA. Aggregation between multiple complementary strands is also prevented in our model. We study interactions between two DNA-functionalized particles as a function of DNA grafting density, lengths of the hybridizing and non-hybridizing parts of DNA, and temperature. The calculated free energies as a function of pair distance between particles qualitatively resemble experimental measurements of DNA-mediated pair interactions.

Fabrication of two-dimensional visible wavelength nanoscale plasmonic structures using hydrogen silsesquioxane based resist

NASA Astrophysics Data System (ADS)

Smith, Kyle Z.; Gadde, Akshitha; Kadiyala, Anand; Dawson, Jeremy M.

2016-03-01

In recent years, the global market for biosensors has continued to increase in combination with their expanding use in areas such as biodefense/detection, home diagnostics, biometric identification, etc. A constant necessity for inexpensive, portable bio-sensing methods, while still remaining simple to understand and operate, is the motivation behind novel concepts and designs. Labeled visible spectrum bio-sensing systems provide instant feedback that is both simple and easy to work with, but are limited by the light intensity thresholds required by the imaging systems. In comparison, label-free bio-sensing systems and other detection modalities like electrochemical, frequency resonance, thermal change, etc., can require additional technical processing steps to convey the final result, increasing the system's complexity and possibly the time required for analysis. Further decrease in the detection limit can be achieved through the addition of plasmonic structures into labeled bio-sensing systems. Nano-structures that operate in the visible spectrum have feature sizes typically in the order of the operating wavelength, calling for high aspect ratio nanoscale fabrication capabilities. In order to achieve these dimensions, electron beam lithography (EBL) is used due to its accurate feature production. Hydrogen silsesquioxane (HSQ) based electron beam resist is chosen for one of its benefits, which is after exposure to oxygen plasma, the patterned resist cures into silicon dioxide (SiO2). These cured features in conjunction with nanoscale gold particles help in producing a high electric field through dipole generation. In this work, a detailed process flow of the fabrication of square lattice of plasmonic structures comprising of gold coated silicon dioxide pillars designed to operate at 560 nm wavelength and produce an intensity increase of roughly 100 percent will be presented.

Structure of the 30 kDa HIV-1 RNA Dimerization Signal by a Hybrid Cryo-EM, NMR, and Molecular Dynamics Approach.

PubMed

Zhang, Kaiming; Keane, Sarah C; Su, Zhaoming; Irobalieva, Rossitza N; Chen, Muyuan; Van, Verna; Sciandra, Carly A; Marchant, Jan; Heng, Xiao; Schmid, Michael F; Case, David A; Ludtke, Steven J; Summers, Michael F; Chiu, Wah

2018-03-06

Cryoelectron microscopy (cryo-EM) and nuclear magnetic resonance (NMR) spectroscopy are routinely used to determine structures of macromolecules with molecular weights over 65 and under 25 kDa, respectively. We combined these techniques to study a 30 kDa HIV-1 dimer initiation site RNA ([DIS] 2 ; 47 nt/strand). A 9 Å cryo-EM map clearly shows major groove features of the double helix and a right-handed superhelical twist. Simulated cryo-EM maps generated from time-averaged molecular dynamics trajectories (10 ns) exhibited levels of detail similar to those in the experimental maps, suggesting internal structural flexibility limits the cryo-EM resolution. Simultaneous inclusion of the cryo-EM map and 2 H-edited NMR-derived distance restraints during structure refinement generates a structure consistent with both datasets and supporting a flipped-out base within a conserved purine-rich bulge. Our findings demonstrate the power of combining global and local structural information from these techniques for structure determination of modest-sized RNAs. Copyright © 2018 Elsevier Ltd. All rights reserved.

Methodologies for Verification and Validation of Space Launch System (SLS) Structural Dynamic Models

NASA Technical Reports Server (NTRS)

Coppolino, Robert N.

2018-01-01

Responses to challenges associated with verification and validation (V&V) of Space Launch System (SLS) structural dynamics models are presented in this paper. Four methodologies addressing specific requirements for V&V are discussed. (1) Residual Mode Augmentation (RMA), which has gained acceptance by various principals in the NASA community, defines efficient and accurate FEM modal sensitivity models that are useful in test-analysis correlation and reconciliation and parametric uncertainty studies. (2) Modified Guyan Reduction (MGR) and Harmonic Reduction (HR, introduced in 1976), developed to remedy difficulties encountered with the widely used Classical Guyan Reduction (CGR) method, are presented. MGR and HR are particularly relevant for estimation of "body dominant" target modes of shell-type SLS assemblies that have numerous "body", "breathing" and local component constituents. Realities associated with configuration features and "imperfections" cause "body" and "breathing" mode characteristics to mix resulting in a lack of clarity in the understanding and correlation of FEM- and test-derived modal data. (3) Mode Consolidation (MC) is a newly introduced procedure designed to effectively "de-feature" FEM and experimental modes of detailed structural shell assemblies for unambiguous estimation of "body" dominant target modes. Finally, (4) Experimental Mode Verification (EMV) is a procedure that addresses ambiguities associated with experimental modal analysis of complex structural systems. Specifically, EMV directly separates well-defined modal data from spurious and poorly excited modal data employing newly introduced graphical and coherence metrics.

A new measure based on degree distribution that links information theory and network graph analysis

PubMed Central

2012-01-01

Background Detailed connection maps of human and nonhuman brains are being generated with new technologies, and graph metrics have been instrumental in understanding the general organizational features of these structures. Neural networks appear to have small world properties: they have clustered regions, while maintaining integrative features such as short average pathlengths. Results We captured the structural characteristics of clustered networks with short average pathlengths through our own variable, System Difference (SD), which is computationally simple and calculable for larger graph systems. SD is a Jaccardian measure generated by averaging all of the differences in the connection patterns between any two nodes of a system. We calculated SD over large random samples of matrices and found that high SD matrices have a low average pathlength and a larger number of clustered structures. SD is a measure of degree distribution with high SD matrices maximizing entropic properties. Phi (Φ), an information theory metric that assesses a system’s capacity to integrate information, correlated well with SD - with SD explaining over 90% of the variance in systems above 11 nodes (tested for 4 to 13 nodes). However, newer versions of Φ do not correlate well with the SD metric. Conclusions The new network measure, SD, provides a link between high entropic structures and degree distributions as related to small world properties. PMID:22726594

Temporal and spatial adaptation of transient responses to local features

PubMed Central

O'Carroll, David C.; Barnett, Paul D.; Nordström, Karin

2012-01-01

Interpreting visual motion within the natural environment is a challenging task, particularly considering that natural scenes vary enormously in brightness, contrast and spatial structure. The performance of current models for the detection of self-generated optic flow depends critically on these very parameters, but despite this, animals manage to successfully navigate within a broad range of scenes. Within global scenes local areas with more salient features are common. Recent work has highlighted the influence that local, salient features have on the encoding of optic flow, but it has been difficult to quantify how local transient responses affect responses to subsequent features and thus contribute to the global neural response. To investigate this in more detail we used experimenter-designed stimuli and recorded intracellularly from motion-sensitive neurons. We limited the stimulus to a small vertically elongated strip, to investigate local and global neural responses to pairs of local “doublet” features that were designed to interact with each other in the temporal and spatial domain. We show that the passage of a high-contrast doublet feature produces a complex transient response from local motion detectors consistent with predictions of a simple computational model. In the neuron, the passage of a high-contrast feature induces a local reduction in responses to subsequent low-contrast features. However, this neural contrast gain reduction appears to be recruited only when features stretch vertically (i.e., orthogonal to the direction of motion) across at least several aligned neighboring ommatidia. Horizontal displacement of the components of elongated features abolishes the local adaptation effect. It is thus likely that features in natural scenes with vertically aligned edges, such as tree trunks, recruit the greatest amount of response suppression. This property could emphasize the local responses to such features vs. those in nearby texture within the scene. PMID:23087617

Newly Collected Multibeam Swath Bathymetry Data Herald a New Phase in Gas-hydrate Research on Lake Baikal

NASA Astrophysics Data System (ADS)

Naudts, L.; Khlystov, O.; Khabuev, A.; Seminskiy, I.; Casier, R.; Cuylaerts, M.; 'chenko, P., General; Synaeve, J.; Vlamynck, N.; de Batist, M. A.; Grachev, M. A.

2009-12-01

Lake Baikal is a large rift lake in Southern Siberia (Russian Federation). It occupies the three central depressions of the Baikal Rift Zone (BRZ): i.e. the Southern, Central and Northern Baikal Basins. Rifting started ca. 30 Ma ago and is still active with a present-day average extension rate of about 4 mm/yr. With a depth of 1637 m, Lake Baikal is the deepest lake in the World. It also holds 20 % of the world’s liquid surface fresh water, which makes it the largest lake in the World in terms of volume. Lake Baikal is also the only freshwater lake in the World with demonstrated occurrences of gas hydrates in its sedimentary infill. Methane hydrates are stable at water depths below 375 m. The presence of hydrates in the sedimentary infill is evidenced by a widespread BSR. Hydrates have also been encountered locally, in the near-bottom sediments of mud-volcano-like structures. In the summer of 2009, the lake floor has been mapped with multibeam swath bathymetry for the first time during a two-month-long survey with RV Titov. Swath bathymetry data were acquired with RCMG’s mobile 50 kHz SeaBeam 1050 multibeam system. In total 12600 km of echosounder tracks were sailed covering 15000 km2, including the Academician Ridge Accommodation Zone, the Central Baikal Basin, the Selenga Delta Accommodation Zone en the South Baikal Basin. In general, the lake floor was mapped starting from water depths of about -200 m to -1637 m, with an average survey depth of -1000 m. The new bathymetric data image the lake-floor morphology in unprecedented detail, revealing many small- and large-scall morphosedimentary, morphostructural and fluid-flow-related features, many of which were hitherto unknown. Known mud-volcano provinces in the Southern and Central Baikal Basins (i.e. the Posolsky Bank mud-volcano province, the Kukuy Canyon mud volcano province and the Olkhon Gate mud-volcano province) were mapped in detail, and several new, often isolated, mud-volcano-like structures were discovered. In addition, different possible fluid-flow features were identified in front of the Selenga Delta. Also the gas-hydrate-bearing areas around the oil seeps of Gorevoi Utes and the methane seeps of Goloustnoye have been mapped in detail, revealing that these hydrate occurrences are not associated with mud-volcano-like structures. The multibeam mapping survey coincided with the 2nd season of exploration of the lake floor by manned MIR submersibles (http://baikalfund.ru/eng/projects/expedition/index.wbp). Several of the MIR dives focused on features imaged by the new bathymetry data, such as gas-hydrate occurrences at methane seeps and oil seeps and in the mud-volcano-like structures, and gas seeps and fluid-flow phenomena along active fault scarps. The multibeam mapping survey was conducted in the framework of SBRAS project 17.8 and FWO Flanders project 1.5.198.09.

Numerical Simulations of a Jovian Ribbon-like Feature

NASA Astrophysics Data System (ADS)

Morales-Juberias, R.; Simon-Miller, A. A.; Dowling, T. E.; Sayanagi, K. M.; Choi, D. S.

2013-12-01

HST observations show the presence of a Ribbon like feature in Jupiter's atmosphere at ≈ 30 degrees North. The presence of this feature seems to correlate with periods when the jet amplitude velocities are highest. Studies of motions can help to determine the nature of the feature. Its detailed structure will be studied using Hubble data at multiple wavelengths and it may be possible to reprocess the long global movies of the Voyager era to study motions at this latitude. Preliminary model results without forcing show that the morphology of the produced instabilities is dependent on the conditions of the background flow and static stability of the atmosphere. Different forcing terms will be used to study the variable nature of this feature. We use numerical simulations to investigate the instabilities produced by different kinds of forcing on the westward jet centered at ≈ 30 degrees North in Jupiter's atmosphere as well as in its two flanking eastward jets to the north and south. Our goal is to understand how the background flow and static stability of the atmosphere affect the ability of the model to reproduce the Ribbon-like cloud pattern observed in Hubble Space Telescope (HST) images of that latitude taken in support of the 2007 New Horizons Jupiter flyby.

Structural controls on geothermal circulation in Surprise Valley, California: A re-evaluation of the Lake City fault zone

USGS Publications Warehouse

Anne E. Egger,; Glen, Jonathan; McPhee, Darcy K.

2014-01-01

Faults and fractures play an important role in the circulation of geothermal fluids in the crust, and the nature of that role varies according to structural setting and state of stress. As a result, detailed geologic and geophysical mapping that relates thermal springs to known structural features is essential to modeling geothermal systems. Published maps of Surprise Valley in northeastern California suggest that the “Lake City fault” or “Lake City fault zone” is a significant structural feature, cutting obliquely across the basin and connecting thermal springs across the valley. Newly acquired geophysical data (audio-magnetotelluric, gravity, and magnetic), combined with existing geochemical and geological data, suggest otherwise. We examine potential field profiles and resistivity models that cross the mapped Lake City fault zone. While there are numerous geophysical anomalies that suggest subsurface structures, they mostly do not coincide with the mapped traces of the Lake City fault zone, nor do they show a consistent signature in gravity, magnetics, or resistivities that would suggest a through-going fault that would promote connectivity through lateral fluid flow. Instead of a single, continuous fault, we propose the presence of a deformation zone associated with the growth of the range-front Surprise Valley fault. The implication for geothermal circulation is that this is a zone of enhanced porosity but lacks length-wise connectivity that could conduct fluids across the valley. Thermal fluid circulation is most likely controlled primarily by interactions between N-S–trending normal faults.

Ultra-Widefield Steering-Based Spectral-Domain Optical Coherence Tomography Imaging of the Retinal Periphery.

PubMed

Choudhry, Netan; Golding, John; Manry, Matthew W; Rao, Rajesh C

2016-06-01

To describe the spectral-domain optical coherence tomography (SD OCT) features of peripheral retinal findings using an ultra-widefield (UWF) steering technique to image the retinal periphery. Observational study. A total of 68 patients (68 eyes) with 19 peripheral retinal features. Spectral-domain OCT-based structural features. Nineteen peripheral retinal features, including vortex vein, congenital hypertrophy of the retinal pigment epithelium, pars plana, ora serrata pearl, typical cystoid degeneration (TCD), cystic retinal tuft, meridional fold, lattice and cobblestone degeneration, retinal hole, retinal tear, rhegmatogenous retinal detachment, typical degenerative senile retinoschisis, peripheral laser coagulation scars, ora tooth, cryopexy scars (retinal tear and treated retinoblastoma scar), bone spicules, white without pressure, and peripheral drusen, were identified by peripheral clinical examination. Near-infrared scanning laser ophthalmoscopy images and SD OCT of these entities were registered to UWF color photographs. Spectral-domain OCT resolved structural features of all peripheral findings. Dilated hyporeflective tubular structures within the choroid were observed in the vortex vein. Loss of retinal lamination, neural retinal attenuation, retinal pigment epithelium loss, or hypertrophy was seen in several entities, including congenital hypertrophy of the retinal pigment epithelium, ora serrata pearl, TCD, cystic retinal tuft, meridional fold, lattice, and cobblestone degenerations. Hyporeflective intraretinal spaces, indicating cystoid or schitic fluid, were seen in ora serrata pearl, ora tooth, TCD, cystic retinal tuft, meridional fold, retinal hole, and typical degenerative senile retinoschisis. The vitreoretinal interface, which often consisted of lamellae-like structures of the condensed cortical vitreous near or adherent to the neural retina, appeared clearly in most peripheral findings, confirming its association with many low-risk and vision-threatening pathologies, such as lattice degeneration, meridional folds, retinal breaks, and rhegmatogenous retinal detachments. Ultra-widefield steering-based SD OCT imaging of the retinal periphery is feasible with current commercially available devices and provides detailed anatomic information of the peripheral retina, including benign and pathologic entities, not previously imaged. This imaging technique may deepen our structural understanding of these entities and their potentially associated macular and systemic pathologies, and may influence decision-making in clinical practice, particularly in areas with teleretinal capabilities but poor access to retinal specialists. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

3-D Structure and Morphology of the S-reflector Detachment Fault, Offshore Galicia, Spain

NASA Astrophysics Data System (ADS)

Schuba, C. N.; Sawyer, D. S.; Gray, G. G.; Morgan, J.; Bull, J.; Shillington, D. J.; Jordan, B.; Reston, T. J.

2017-12-01

The crustal architecture of passive continental margins provides valuable clues for understanding rift initiation and evolution. The Galicia margin is an archetypal magma-poor margin displaying exhumed serpentinized mantle, and is an optimal setting in which to examine rift-related processes. A new 3-D seismic reflection volume images this margin in great detail. The S-reflector detachment fault, one of the most prominent structural features associated with the Galicia margin, is imaged as a continuous interface over an area of 600 km2. The top and base of the fault zone can be mapped independently, which enables seismic attribute analysis of this significant structure. RMS amplitude maps extracted from this interface show localized patches of high amplitude stripes that coincide with thickness variations of the fault zone and undulations in the bounding surfaces of the fault. These variations bear similarities to grooves on the fault surface such as slickensides, and appear to have developed as the fault zone evolved. These features thus represent good indicators of the kinematics of the fault system. In general, there is good correlation between S-reflector morphology and the overriding fault intersections; however this relationship does not appear to be present with the fault gouge thickness.

Space-time evolution of a growth fold (Betic Cordillera, Spain). Evidences from 3D geometrical modelling

NASA Astrophysics Data System (ADS)

Martin-Rojas, Ivan; Alfaro, Pedro; Estévez, Antonio

2014-05-01

We present a study that encompasses several software tools (iGIS©, ArcGIS©, Autocad©, etc.) and data (geological mapping, high resolution digital topographic data, high resolution aerial photographs, etc.) to create a detailed 3D geometric model of an active fault propagation growth fold. This 3D model clearly shows structural features of the analysed fold, as well as growth relationships and sedimentary patterns. The results obtained permit us to discuss the kinematics and structural evolution of the fold and the fault in time and space. The study fault propagation fold is the Crevillente syncline. This fold represents the northern limit of the Bajo Segura Basin, an intermontane basin in the Eastern Betic Cordillera (SE Spain) developed from upper Miocene on. 3D features of the Crevillente syncline, including growth pattern, indicate that limb rotation and, consequently, fault activity was higher during Messinian than during Tortonian; consequently, fault activity was also higher. From Pliocene on our data point that limb rotation and fault activity steadies or probably decreases. This in time evolution of the Crevillente syncline is not the same all along the structure; actually the 3D geometric model indicates that observed lateral heterogeneity is related to along strike variation of fault displacement.

Petrography of impact glasses and melt breccias from the El'gygytgyn impact structure, Russia

NASA Astrophysics Data System (ADS)

Pittarello, Lidia; Koeberl, Christian

2013-07-01

The El'gygytgyn impact structure, 18 km in diameter and 3.6 Ma old, in Arctic Siberia, Russia, is the only impact structure on Earth mostly excavated in acidic volcanic rocks. The Late Cretaceous volcanic target includes lavas, tuffs, and ignimbrites of rhyolitic, dacitic, and andesitic composition, and local occurrence of basalt. Although the ejecta blanket around the crater is nearly completely eroded, bomb-shaped impact glasses, redeposited after the impact event, occur in lacustrine terraces within the crater. Here we present detailed petrographic descriptions of newly collected impact glass-bearing samples. The observed features contribute to constrain the formation of the melt and its cooling history within the framework of the impact process. The collected samples can be grouped into two types, characterized by specific features: (1) "pure" glasses, containing very few clasts or new crystals and which were likely formed during the early stages of cratering and (2) a second type, which represents composite samples with impact melt breccia lenses embedded in silicate glass. These mixed samples probably resulted from inclusion of unmelted impact debris during ejection and deposition. After deposition the glassy portions continued to deform, whereas the impact melt breccia inclusions that probably had already cooled down behaved as rigid bodies in the flow.

Multiscale Processes in Magnetic Reconnection

NASA Astrophysics Data System (ADS)

Surjalal Sharma, A.; Jain, Neeraj

The characteristic scales of the plasma processes in magnetic reconnection range from the elec-tron skin-depth to the magnetohydrodynamic (MHD) scale, and cross-scale coupling among them play a key role. Modeling these processes requires different physical models, viz. kinetic, electron-magnetohydrodynamics (EMHD), Hall-MHD, and MHD. The shortest scale processes are at the electron scale and these are modeled using an EMHD code, which provides many features of the multiscale behavior. In simulations using initial conditions consisting of pertur-bations with many scale sizes the reconnection takes place at many sites and the plasma flows from these interact with each other. This leads to thin current sheets with length less than 10 electron skin depths. The plasma flows also generate current sheets with multiple peaks, as observed by Cluster. The quadrupole structure of the magnetic field during reconnection starts on the electron scale and the interaction of inflow to the secondary sites and outflow from the dominant site generates a nested structure. In the outflow regions, the interaction of the electron outflows generated at the neighboring sites lead to the development of electron vortices. A signature of the nested structure of the Hall field is seen in Cluster observations, and more details of these features are expected from MMS.

The structure of distractor-response bindings: Conditions for configural and elemental integration.

PubMed

Moeller, Birte; Frings, Christian; Pfister, Roland

2016-04-01

Human action control is influenced by bindings between perceived stimuli and responses carried out in their presence. Notably, responses given to a target stimulus can also be integrated with additional response-irrelevant distractor stimuli that accompany the target (distractor-response binding). Subsequently reencountering such a distractor then retrieves the associated response. Although a large body of evidence supports the existence of this effect, the specific structure of distractor-response bindings is still unclear. Here, we test the predictions derived from 2 possible assumptions about the structure of bindings between distractors and responses. According to a configural approach, the entire distractor object is integrated with a response, and only upon repetition of the entire distractor object the associated response would be retrieved. According to an elemental approach, one would predict integration of individual distractor features with the response and retrieval due to the repetition of an individual distractor feature. Four experiments indicate that both, configural and elemental bindings exist and specify boundary conditions for each type of binding. These findings provide detailed insights into the architecture of bindings between response-irrelevant stimuli and actions and thus allow for specifying how distractor stimuli influence human behavior. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Forced Folds and Craters of Elevation in the Afar

NASA Astrophysics Data System (ADS)

Hetherington, Rachel; Mussetti, Giulio; Hagos, Miruts; Deering, Chad; Corti, Giacomo; Magee, Craig; Ian, Bastow; van Wyk de Vries, Benjamin; Marques, Alvaro

2015-04-01

Uplifts caused by magma intrusion have been observed and mapped since the pioneering work of von Buch two hundred years ago. Von Buch's "Craters of elevation theory", developed in the Auvergne and Canaries, was, unfortunately, discredited and mostly forgotten until recent work has shown that the forced folds mapped in seismic sections in sedimentary basins are the same type of feature. Also, these magmatic bulges are being found on an increasing number of volcanoes. The Danakil region of Ethiopia contains a superb range of forced folds with craters of elevation, which we have mapped using Google Earth and other satellite imagery, and some ground truthing. This preliminary work provides a geological map that is inspired from the 1970 Barberi and Vallet map, and which sets out in detail the structure and lava flow units of this area. We describe the main structures of each uplift, and suggest a preliminary general structural evolutionary pattern that provides a model for future research. This work has been untertaken by a group from multiple universities sharing interpretations and data in an open format. We aim to continue this work to study these superb geological features. Their superb nature and preservation is such that we would also press for them to be made a geoheritage reserve of global importance: Either a Geopark or a World Heritage site.

Applying Gradient Descent in Convolutional Neural Networks

NASA Astrophysics Data System (ADS)

Cui, Nan

2018-04-01

With the development of the integrated circuit and computer science, people become caring more about solving practical issues via information technologies. Along with that, a new subject called Artificial Intelligent (AI) comes up. One popular research interest of AI is about recognition algorithm. In this paper, one of the most common algorithms, Convolutional Neural Networks (CNNs) will be introduced, for image recognition. Understanding its theory and structure is of great significance for every scholar who is interested in this field. Convolution Neural Network is an artificial neural network which combines the mathematical method of convolution and neural network. The hieratical structure of CNN provides it reliable computer speed and reasonable error rate. The most significant characteristics of CNNs are feature extraction, weight sharing and dimension reduction. Meanwhile, combining with the Back Propagation (BP) mechanism and the Gradient Descent (GD) method, CNNs has the ability to self-study and in-depth learning. Basically, BP provides an opportunity for backwardfeedback for enhancing reliability and GD is used for self-training process. This paper mainly discusses the CNN and the related BP and GD algorithms, including the basic structure and function of CNN, details of each layer, the principles and features of BP and GD, and some examples in practice with a summary in the end.

Proton channel models

PubMed Central

Pupo, Amaury; Baez-Nieto, David; Martínez, Agustín; Latorre, Ramón; González, Carlos

2014-01-01

Voltage-gated proton channels are integral membrane proteins with the capacity to permeate elementary particles in a voltage and pH dependent manner. These proteins have been found in several species and are involved in various physiological processes. Although their primary topology is known, lack of details regarding their structures in the open conformation has limited analyses toward a deeper understanding of the molecular determinants of their function and regulation. Consequently, the function-structure relationships have been inferred based on homology models. In the present work, we review the existing proton channel models, their assumptions, predictions and the experimental facts that support them. Modeling proton channels is not a trivial task due to the lack of a close homolog template. Hence, there are important differences between published models. This work attempts to critically review existing proton channel models toward the aim of contributing to a better understanding of the structural features of these proteins. PMID:24755912

Structural basis for precursor protein-directed ribosomal peptide macrocyclization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Kunhua; Condurso, Heather L.; Li, Gengnan

Macrocyclization is a common feature of natural product biosynthetic pathways including the diverse family of ribosomal peptides. Microviridins are architecturally complex cyanobacterial ribosomal peptides that target proteases with potent reversible inhibition. The product structure is constructed via three macrocyclizations catalyzed sequentially by two members of the ATP-grasp family, a unique strategy for ribosomal peptide macrocyclization. Here we describe in detail the structural basis for the enzyme-catalyzed macrocyclizations in the microviridin J pathway of Microcystis aeruginosa. The macrocyclases MdnC and MdnB interact with a conserved α-helix of the precursor peptide using a novel precursor-peptide recognition mechanism. The results provide insight intomore » the unique protein–protein interactions that are key to the chemistry, suggest an origin for the natural combinatorial synthesis of microviridin peptides, and provide a framework for future engineering efforts to generate designed compounds.« less

Tie2 and Eph Receptor Tyrosine Kinase Activation and Signaling

PubMed Central

Barton, William A.; Dalton, Annamarie C.; Seegar, Tom C.M.; Himanen, Juha P.

2014-01-01

The Eph and Tie cell surface receptors mediate a variety of signaling events during development and in the adult organism. As other receptor tyrosine kinases, they are activated on binding of extracellular ligands and their catalytic activity is tightly regulated on multiple levels. The Eph and Tie receptors display some unique characteristics, including the requirement of ligand-induced receptor clustering for efficient signaling. Interestingly, both Ephs and Ties can mediate different, even opposite, biological effects depending on the specific ligand eliciting the response and on the cellular context. Here we discuss the structural features of these receptors, their interactions with various ligands, as well as functional implications for downstream signaling initiation. The Eph/ephrin structures are already well reviewed and we only provide a brief overview on the initial binding events. We go into more detail discussing the Tie-angiopoietin structures and recognition. PMID:24478383

Gas flows in radial micro-nozzles with pseudo-shocks

NASA Astrophysics Data System (ADS)

Kiselev, S. P.; Kiselev, V. P.; Zaikovskii, V. N.

2018-07-01

In the present paper, results of an experimental and numerical study of supersonic gas flows in radial micro-nozzles are reported. A distinguishing feature of such flows is the fact that two factors, the nozzle divergence and the wall friction force, exert a substantial influence on the flow structure. Under the action of the wall friction force, in the micro-nozzle there forms a pseudo-shock that separates the supersonic from subsonic flow region. The position of the pseudo-shock can be evaluated from the condition of flow blockage in the nozzle exit section. A detailed qualitative and quantitative analysis of gas flows in radial micro-nozzles is given. It is shown that the gas flow in a micro-nozzle is defined by the complicated structure of the boundary layer in the micro-nozzle, this structure being dependent on the width-to-radius ratio of the nozzle and its inlet-to-outlet pressure ratio.

Recent research in flaxseed (oil seed) on molecular structure and metabolic characteristics of protein, heat processing-induced effect and nutrition with advanced synchrotron-based molecular techniques.

PubMed

Doiron, Kevin J; Yu, Peiqiang

2017-01-02

Advanced synchrotron radiation-based infrared microspectroscopy is able to reveal feed and food structure feature at cellular and molecular levels and simultaneously provides composition, structure, environment, and chemistry within intact tissue. However, to date, this advanced synchrotron-based technique is still seldom known to food and feed scientists. This article aims to provide detailed background for flaxseed (oil seed) protein research and then review recent progress and development in flaxseed research in ruminant nutrition in the areas of (1) dietary inclusion of flaxseed in rations; (2) heat processing effect; (3) assessing dietary protein; (4) synchrotron-based Fourier transform infrared microspectroscopy as a tool of nutritive evaluation within cellular and subcellular dimensions; (5) recent synchrotron applications in flaxseed research on a molecular basis. The information described in this paper gives better insight in flaxseed research progress and update.

RECEPTOR AFFINITY AND PHOSPHODIESTERASES 4B AND 10A ACTIVITY OF OCTAHYDRO- AND 6,7-DIMETHOXY-3,4-DIHYDRO- ISOQUINOLIN-2(1H)-YL-ALKYL DERIVATIVES OF IMIDAZO- AND PYRIMIDINO[2,1-f]PURINES.

PubMed

Zagórska, Agnieszka; Gryzło, Beata; Satała, Grzegorz; Bojarski, Andrzej J; Głuch-Lutwin, Monika; Mordyl, Barbara; Kazek, Grzegorz; Pawłowski, Maciej

2016-01-01

A series of octahydro- and 6,7-dimethoxy-3,4-dihydro- isoquinolin-2(1H)-yl-alkyl derivatives of imidazo- and pyrimidino[2,1-f]purines were synthesized and biologically evaluated in in vitro competition binding experiments for serotonin 5-HT(1A), 5-HT(6), 5-HT(7), and dopamine D2 receptors and inhibitory potencies for phosphodiesterases - PDE4B1 and PDE10A. The structure-activity relationships allowed to determine the structural features responsible for receptor and enzyme activity. Compound 5 (8-(4-(6,7-dimethoxy-3,4-dihydroiso- quinolin-2(1H)butyl)1,3-dimethyl-H-imidazo[2,1-f]purine-2,4(3H,8H)-dione) could be regarded as promising structure for further modification and detailed mechanistic study for obtained hybrid ligands.

Three-dimensional Organization of Layered Apical Cytoskeletal Networks Associated with Mouse Airway Tissue Development

NASA Astrophysics Data System (ADS)

Tateishi, Kazuhiro; Nishida, Tomoki; Inoue, Kanako; Tsukita, Sachiko

2017-03-01

The cytoskeleton is an essential cellular component that enables various sophisticated functions of epithelial cells by forming specialized subcellular compartments. However, the functional and structural roles of cytoskeletons in subcellular compartmentalization are still not fully understood. Here we identified a novel network structure consisting of actin filaments, intermediate filaments, and microtubules directly beneath the apical membrane in mouse airway multiciliated cells and in cultured epithelial cells. Three-dimensional imaging by ultra-high voltage electron microscopy and immunofluorescence revealed that the morphological features of each network depended on the cell type and were spatiotemporally integrated in association with tissue development. Detailed analyses using Odf2 mutant mice, which lack ciliary basal feet and apical microtubules, suggested a novel contribution of the intermediate filaments to coordinated ciliary beating. These findings provide a new perspective for viewing epithelial cell differentiation and tissue morphogenesis through the structure and function of apical cytoskeletal networks.

DFT based vibrational spectroscopic investigations and biological activity of toxic material monocrotophos

NASA Astrophysics Data System (ADS)

Nimmi, D. E.; Sam, S. P. Chandhini; Praveen, S. G.; Binoy, J.

2018-05-01

Many organophosphate compounds exhibiting toxicity are widely used as pesticides and insecticides whose structural features can be explained excellently using geometric simulation using density functional theory and vibrational spectrum. In this work, the molecular structural parameters and vibrational frequencies of the fundamental modes of Monocrotophoshave been obtained using Density functional theory (DFT), using B3LYP functional with 6-311++G(d, p) basis sets and the detailed vibrational analysis of FT-IR and FT-Ramanspectral bands have been carried out using potential energy distribution (PED). The deviation from the resonance structure of phosphate group due to `bridging of oxygen' and π-resonance of amides has been investigated based on the spectral and geometric data. The molecular docking simulation of Monocrotophos with BSA and DNA has been performed to find the mode of binding and the interactions with BSA has been investigated with UV-Visible spectroscopic method, to assess the strength of binding.

Temporal Structure of Volatility Fluctuations

NASA Astrophysics Data System (ADS)

Wang, Fengzhong; Yamasaki, Kazuko; Stanley, H. Eugene; Havlin, Shlomo

Volatility fluctuations are of great importance for the study of financial markets, and the temporal structure is an essential feature of fluctuations. To explore the temporal structure, we employ a new approach based on the return interval, which is defined as the time interval between two successive volatility values that are above a given threshold. We find that the distribution of the return intervals follows a scaling law over a wide range of thresholds, and over a broad range of sampling intervals. Moreover, this scaling law is universal for stocks of different countries, for commodities, for interest rates, and for currencies. However, further and more detailed analysis of the return intervals shows some systematic deviations from the scaling law. We also demonstrate a significant memory effect in the return intervals time organization. We find that the distribution of return intervals is strongly related to the correlations in the volatility.

Structural character of the Ghost Dance fault, Yucca Mountain, Nevada

USGS Publications Warehouse

Spengler, R.W.; Braun, C.A.; Linden, R.M.; Martin, L.G.; Ross-Brown, D. M.; Blackburn, R.L.

1993-01-01

Detailed structural mapping of an area that straddles the southern part of the Ghost Dance Fault has revealed the presence of several additional subparallel to anastomosing faults. These faults, mapped at a scale of 1:240, are: 1) dominantly north trending, 2) present on both the upthrown and downthrown sides of the surface trace of the Ghost Dance fault, 3) near-vertical features that commonly offset strata down to the west by 3 to 6 m (10 to 20 ft), and 4) commonly spaced 15 to 46 m (50 to 150 ft) apart. The zone also exhibits a structural fabric, containing an abundance of northwest-trending fractures. The width of the zone appears to be at least 213 m (700 ft) near the southernmost boundary of the study area but remains unknown near the northern extent of the study area, where the width of the study area is only 183 m (600 ft).

Measuring the impact of final demand on global production system based on Markov process

NASA Astrophysics Data System (ADS)

Xing, Lizhi; Guan, Jun; Wu, Shan

2018-07-01

Input-output table is a comprehensive and detailed in describing the national economic systems, consisting of supply and demand information among various industrial sectors. The complex network, a theory and method for measuring the structure of complex system, can depict the structural properties of social and economic systems, and reveal the complicated relationships between the inner hierarchies and the external macroeconomic functions. This paper tried to measure the globalization degree of industrial sectors on the global value chain. Firstly, it constructed inter-country input-output network models to reproduce the topological structure of global economic system. Secondly, it regarded the propagation of intermediate goods on the global value chain as Markov process and introduced counting first passage betweenness to quantify the added processing amount when globally final demand stimulates this production system. Thirdly, it analyzed the features of globalization at both global and country-sector level

Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products.

PubMed

Kjer, Julia; Debbab, Abdessamad; Aly, Amal H; Proksch, Peter

2010-03-01

Marine-derived fungi have been shown in recent years to produce a plethora of new bioactive secondary metabolites, some of them featuring new carbon frameworks hitherto unprecedented in nature. These compounds are of interest as new lead structures for medicine as well as for plant protection. The aim of this protocol is to give a detailed description of methods useful for the isolation and cultivation of fungi associated with various marine organisms (sponges, algae and mangrove plants) for the extraction, characterization and structure elucidation of biologically active secondary metabolites produced by these marine-derived endophytic fungi, and for the preliminary evaluation of their pharmacological properties based on rapid 'in house' screening systems. Some results exemplifying the positive outcomes of the protocol are given at the end. From sampling in marine environment to completion of the structure elucidation and bioactivity screening, a period of at least 3 months has to be scheduled.

On the Origin of Banded Structure in Dusty Protoplanetary Disks: HL Tau and TW Hya

NASA Astrophysics Data System (ADS)

Boley, A. C.

2017-11-01

Recent observations of HL Tau revealed remarkably detailed structure within the system’s circumstellar disk. A range of hypotheses have been proposed to explain the morphology, including, e.g., planet-disk interactions, condensation fronts, and secular gravitational instabilities. While embedded planets seem to be able to explain some of the major structure in the disk through interactions with gas and dust, the substructures, such as low-contrast rings and bands, are not so easily reproduced. Here, we show that dynamical interactions between three planets (only two of which are modeled) and an initial population of large planetesimals can potentially explain both the major and minor banded features within the system. In this context, the small grains, which are coupled to the gas and reveal the disk morphology, are produced by the collisional evolution of the newly formed planetesimals, which are ubiquitous in the system and are decoupled from the gas.

Spin texture of the surface state of three-dimensional Dirac material Ca3PbO

NASA Astrophysics Data System (ADS)

Kariyado, Toshikaze

2015-04-01

The bulk and surface electronic structures of a candidate three-dimensional Dirac material Ca3PbO and its family are discussed especially focusing on the spin texture on the surface states. We first explain the basic features of the bulk band structure of Ca3PbO, such as emergence of Dirac fermions near the Fermi energy, and compare it with the other known three-dimensional Dirac semimetals. Then, the surface bands and spin-texture on them are investigated in detail. It is shown that the surface bands exhibit strong momentum-spin locking, which may be useful in some application for spin manipulation, induced by a combination of the inversion symmetry breaking at the surface and the strong spin-orbit coupling of Pb atoms. The surface band structure and the spin-textures are sensitive to the surface types.

Factors Influencing Progressive Failure Analysis Predictions for Laminated Composite Structure

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.

2008-01-01

Progressive failure material modeling methods used for structural analysis including failure initiation and material degradation are presented. Different failure initiation criteria and material degradation models are described that define progressive failure formulations. These progressive failure formulations are implemented in a user-defined material model for use with a nonlinear finite element analysis tool. The failure initiation criteria include the maximum stress criteria, maximum strain criteria, the Tsai-Wu failure polynomial, and the Hashin criteria. The material degradation model is based on the ply-discounting approach where the local material constitutive coefficients are degraded. Applications and extensions of the progressive failure analysis material model address two-dimensional plate and shell finite elements and three-dimensional solid finite elements. Implementation details are described in the present paper. Parametric studies for laminated composite structures are discussed to illustrate the features of the progressive failure modeling methods that have been implemented and to demonstrate their influence on progressive failure analysis predictions.

Coarse-grained mechanics of viral shells

NASA Astrophysics Data System (ADS)

Klug, William S.; Gibbons, Melissa M.

2008-03-01

We present an approach for creating three-dimensional finite element models of viral capsids from atomic-level structural data (X-ray or cryo-EM). The models capture heterogeneous geometric features and are used in conjunction with three-dimensional nonlinear continuum elasticity to simulate nanoindentation experiments as performed using atomic force microscopy. The method is extremely flexible; able to capture varying levels of detail in the three-dimensional structure. Nanoindentation simulations are presented for several viruses: Hepatitis B, CCMV, HK97, and φ29. In addition to purely continuum elastic models a multiscale technique is developed that combines finite-element kinematics with MD energetics such that large-scale deformations are facilitated by a reduction in degrees of freedom. Simulations of these capsid deformation experiments provide a testing ground for the techniques, as well as insight into the strength-determining mechanisms of capsid deformation. These methods can be extended as a framework for modeling other proteins and macromolecular structures in cell biology.

Comparison and experimental validation of two potential resonant viscosity sensors in the kilohertz range

NASA Astrophysics Data System (ADS)

Lemaire, Etienne; Heinisch, Martin; Caillard, Benjamin; Jakoby, Bernhard; Dufour, Isabelle

2013-08-01

Oscillating microstructures are well established and find application in many fields. These include force sensors, e.g. AFM micro-cantilevers or accelerometers based on resonant suspended plates. This contribution presents two vibrating mechanical structures acting as force sensors in liquid media in order to measure hydrodynamic interactions. Rectangular cross section microcantilevers as well as circular cross section wires are investigated. Each structure features specific benefits, which are discussed in detail. Furthermore, their mechanical parameters and their deflection in liquids are characterized. Finally, an inverse analytical model is applied to calculate the complex viscosity near the resonant frequency for both types of structures. With this approach it is possible to determine rheological parameters in the kilohertz range in situ within a few seconds. The monitoring of the complex viscosity of yogurt during the fermentation process is used as a proof of concept to qualify at least one of the two sensors in opaque mixtures.

The Centre for Speech, Language and the Brain (CSLB) concept property norms.

PubMed

Devereux, Barry J; Tyler, Lorraine K; Geertzen, Jeroen; Randall, Billi

2014-12-01

Theories of the representation and processing of concepts have been greatly enhanced by models based on information available in semantic property norms. This information relates both to the identity of the features produced in the norms and to their statistical properties. In this article, we introduce a new and large set of property norms that are designed to be a more flexible tool to meet the demands of many different disciplines interested in conceptual knowledge representation, from cognitive psychology to computational linguistics. As well as providing all features listed by 2 or more participants, we also show the considerable linguistic variation that underlies each normalized feature label and the number of participants who generated each variant. Our norms are highly comparable with the largest extant set (McRae, Cree, Seidenberg, & McNorgan, 2005) in terms of the number and distribution of features. In addition, we show how the norms give rise to a coherent category structure. We provide these norms in the hope that the greater detail available in the Centre for Speech, Language and the Brain norms should further promote the development of models of conceptual knowledge. The norms can be downloaded at www.csl.psychol.cam.ac.uk/propertynorms.

Aryl-Aryl Interactions in Designed Peptide Folds: Spectroscopic Characteristics and Placement Issues for Optimal Structure Stabilization

PubMed Central

Anderson, Jordan M.; Kier, Brandon; Jurban, Brice; Byrne, Aimee; Shu, Irene; Eidenschink, Lisa A.; Shcherbakov, Alexander A.; Hudson, Mike; Fesinmeyer, R. M.; Andersen, Niels H.

2017-01-01

We have extended our studies of Trp/Trp to other Aryl/Aryl through-space interactions that stabilize hairpins and other small polypeptide folds. Herein we detail the NMR and CD spectroscopic features of these types of interactions. NMR data remains the best diagnostic for characterizing the common T-shape orientation. Designated as an edge-to-face (EtF or FtE) interaction, large ring current shifts are produced at the edge aryl ring hydrogens and, in most cases, large exciton couplets appear in the far UV circular dichroic (CD) spectrum. The preference for the face aryl in FtE clusters is W≫Y≥F (there are some exceptions in the Y/F order); this sequence corresponds to the order of fold stability enhancement and always predicts the amplitude of the lower energy feature of the exciton couplet in the CD spectrum. The CD spectra for FtE W/W, W/Y, Y/W, and Y/Y pairs all include an intense feature at 225–232 nm. An additional couplet feature seen for W/Y, W/F, Y/Y and F/Y clusters, is a negative feature at 197–200 nm. Tyr/Tyr (as well as F/Y and F/F) interactions produce much smaller exciton couplet amplitudes. The Trp-cage fold was employed to search for the CD effects of other Trp/Trp and Trp/Tyr cluster geometries: several were identified. In this account, we provide additional examples of the application of cross-strand aryl/aryl clusters for the design of stable β-sheet models and a scale of fold stability increments associated with all possible FtE Ar/Ar clusters in several structural contexts. PMID:26850220

Automated adaptive inference of phenomenological dynamical models.

PubMed

Daniels, Bryan C; Nemenman, Ilya

2015-08-21

Dynamics of complex systems is often driven by large and intricate networks of microscopic interactions, whose sheer size obfuscates understanding. With limited experimental data, many parameters of such dynamics are unknown, and thus detailed, mechanistic models risk overfitting and making faulty predictions. At the other extreme, simple ad hoc models often miss defining features of the underlying systems. Here we develop an approach that instead constructs phenomenological, coarse-grained models of network dynamics that automatically adapt their complexity to the available data. Such adaptive models produce accurate predictions even when microscopic details are unknown. The approach is computationally tractable, even for a relatively large number of dynamical variables. Using simulated data, it correctly infers the phase space structure for planetary motion, avoids overfitting in a biological signalling system and produces accurate predictions for yeast glycolysis with tens of data points and over half of the interacting species unobserved.

The radiation biology of the thyroid.

PubMed

Malone, J F

1975-10-01

The structure and function of the thyroid gland are described. A detailed analysis of population kinetics in the gland suggests a method of measuring cell survival after irradiation that has many features in common with methods used in other mammalian cell systems. This method is used to obtain survival curves for thyroid cells afer irradiation. The effects on survival of splitting the radiation dose into two or multiple fractions, radiation type, and radioprotective agents are also examined. In the light of these data the tolerance of thyroid tissue to radiation exposure under various conditions is discussed. The dosimetry and biological effects of 125I and 131I are described in detail, and compared with X-rays. Radioiodine treatment of thyrotoxicosis is presented in relation to the known biological effects of the isotopes on the gland. Carcinogenic action of ionizing radiations in the thyroid are reviewed with particular reference to the clinical consequences of observations in this field.

Summary statistics in auditory perception.

PubMed

McDermott, Josh H; Schemitsch, Michael; Simoncelli, Eero P

2013-04-01

Sensory signals are transduced at high resolution, but their structure must be stored in a more compact format. Here we provide evidence that the auditory system summarizes the temporal details of sounds using time-averaged statistics. We measured discrimination of 'sound textures' that were characterized by particular statistical properties, as normally result from the superposition of many acoustic features in auditory scenes. When listeners discriminated examples of different textures, performance improved with excerpt duration. In contrast, when listeners discriminated different examples of the same texture, performance declined with duration, a paradoxical result given that the information available for discrimination grows with duration. These results indicate that once these sounds are of moderate length, the brain's representation is limited to time-averaged statistics, which, for different examples of the same texture, converge to the same values with increasing duration. Such statistical representations produce good categorical discrimination, but limit the ability to discern temporal detail.

Idealized gas turbine combustor for performance research and validation of large eddy simulations.

PubMed

Williams, Timothy C; Schefer, Robert W; Oefelein, Joseph C; Shaddix, Christopher R

2007-03-01

This paper details the design of a premixed, swirl-stabilized combustor that was designed and built for the express purpose of obtaining validation-quality data for the development of large eddy simulations (LES) of gas turbine combustors. The combustor features nonambiguous boundary conditions, a geometrically simple design that retains the essential fluid dynamics and thermochemical processes that occur in actual gas turbine combustors, and unrestrictive access for laser and optical diagnostic measurements. After discussing the design detail, a preliminary investigation of the performance and operating envelope of the combustor is presented. With the combustor operating on premixed methane/air, both the equivalence ratio and the inlet velocity were systematically varied and the flame structure was recorded via digital photography. Interesting lean flame blowout and resonance characteristics were observed. In addition, the combustor exhibited a large region of stable, acoustically clean combustion that is suitable for preliminary validation of LES models.

Old and new ideas in ferroelectric liquid crystal technology

NASA Astrophysics Data System (ADS)

Lagerwall, Sven T.; Matuszczyk, M.; Matuszczyk, T.

1998-02-01

Ferroelectric liquid crystals (FLC) are to conventional liquid crystal what Gallium Arsenide is to Silicon in the semiconductor area. The first generation of FLC displays in now present on the market and has some outstanding features based on the symmetric bistability which may be achieved in these materials. One of the greatest challenges for the next generation is to achieve an analog grey scale out of an essentially digital principle. We will analyze in some detail which major problems had to be solved to reach the present state and show how the final steps could be taken toward a new state-of-the-art level in liquid crystal devices. In the last decade university research and industrial R and D have almost equally contributed to treat the very serious complications caused by the so-called chevron structures We will review this important topic in particular detail.

Automated adaptive inference of phenomenological dynamical models

PubMed Central

Daniels, Bryan C.; Nemenman, Ilya

2015-01-01

Dynamics of complex systems is often driven by large and intricate networks of microscopic interactions, whose sheer size obfuscates understanding. With limited experimental data, many parameters of such dynamics are unknown, and thus detailed, mechanistic models risk overfitting and making faulty predictions. At the other extreme, simple ad hoc models often miss defining features of the underlying systems. Here we develop an approach that instead constructs phenomenological, coarse-grained models of network dynamics that automatically adapt their complexity to the available data. Such adaptive models produce accurate predictions even when microscopic details are unknown. The approach is computationally tractable, even for a relatively large number of dynamical variables. Using simulated data, it correctly infers the phase space structure for planetary motion, avoids overfitting in a biological signalling system and produces accurate predictions for yeast glycolysis with tens of data points and over half of the interacting species unobserved. PMID:26293508

Modeling Line Emission from Structures Seen at High Resolution in the Nebulae m1 and M16

NASA Astrophysics Data System (ADS)

Sankrit, Ravi

1998-12-01

Narrow band images of the Crab Nebula supernova remnant and of the Eagle Nebula H II region taken with the Hubble Space Telescope (HST) show the ionization structure of the emitting gas in unprecedented detail because of the high spatial resolution. The physics of the emission processes-shock excited emission and photoionized emission-is well understood. Sophisticated numerical codes are used to model the ionization structure and emission observed in these images. It is found that the thin skin of material around the Crab synchrotron nebula visible in (O III) λ5007 emission is best explained as the cooling region behind a shock driven by the synchrotron nebula into a surrounding remnant of freely expanding ejecta. Shock models, with parameters derived from independently known properties of the Crab, explain the observed spectrum of the skin while photoionization models fail to explain the observed strength of high ionization lines such as C IV λ1549. This result is clear evidence that the synchrotron nebula is interacting with an extended remnant of ejecta, which in turn has significant implications for the structure and evolution of the Crab. At HST resolution, it is seen that low ionization emission, from lines such as (O I) λ6300, is concentrated in sharp structures while high ionization emission (from (O III) λ5007) is much more diffuse. Individual filaments are found to lie along a sequence of ionization structure ranging from features in which all lines are concentrated in the same compact volume through features with low ionization cores surrounded by high ionization envelopes. Photoionization models of cylindrically symmetrical filaments with varying 'core-halo' density profiles can match the observed variation in the filament structure in the Crab. A photoionization model of a uniform low density medium matches the extended diffuse component which dominates the high ionization emission. It is found that detailed knowledge of the filament structures present in an aperture is needed to correctly interpret ground-based spectra of the Crab. The images also show that many filament cores coincide with dust extinction features, which suggest that the dust to gas mass ratio may be up to an order of magnitude higher than is typical in the interstellar medium. Nebula show the interface between the ionized gas and the molecular cloud in tangency against the background of the ionized cavity which constitutes the H II region. A photoionization model using a density profile for the photoevaporative flow that is expected at such an interface is successful at explaining the observed emission profiles of Hα λ6563, (S II) λλ6716,6731, and (O III) λ5007. The ionizing flux is well constrained by the Hα emission and the sulphur abundance is constrained by the peak of the (S II) emission. A grid of models using the same density profiles shows how various emission properties depend on the ionizing continuum shape, ionizing flux and elemental abundances.

10 CFR 1045.17 - Classification levels.

Code of Federal Regulations, 2014 CFR

2014-01-01

... classification include detailed technical descriptions of critical features of a nuclear explosive design that... classification include designs for specific weapon components (not revealing critical features), key features of uranium enrichment technologies, or specifications of weapon materials. (3) Confidential. The Director of...

10 CFR 1045.17 - Classification levels.

Code of Federal Regulations, 2013 CFR

2013-01-01

... classification include detailed technical descriptions of critical features of a nuclear explosive design that... classification include designs for specific weapon components (not revealing critical features), key features of uranium enrichment technologies, or specifications of weapon materials. (3) Confidential. The Director of...

10 CFR 1045.17 - Classification levels.

Code of Federal Regulations, 2011 CFR

2011-01-01

... classification include detailed technical descriptions of critical features of a nuclear explosive design that... classification include designs for specific weapon components (not revealing critical features), key features of uranium enrichment technologies, or specifications of weapon materials. (3) Confidential. The Director of...

10 CFR 1045.17 - Classification levels.

Code of Federal Regulations, 2012 CFR

2012-01-01

... classification include detailed technical descriptions of critical features of a nuclear explosive design that... classification include designs for specific weapon components (not revealing critical features), key features of uranium enrichment technologies, or specifications of weapon materials. (3) Confidential. The Director of...

Morphology and shallow structure of seafloor mounds in the Canary Basin (Eastern Central Atlantic Ocean)

NASA Astrophysics Data System (ADS)

Sanchez-Guillamón, O.; Vázquez, J. T.; Palomino, D.; Medialdea, T.; Fernández-Salas, L. M.; León, R.; Somoza, L.

2018-07-01

The increasing volume of high-resolution multibeam bathymetry data collected along continental margins and adjacent deep seafloor regions is providing further opportunities to study new morphological seafloor features in deep water environments. In this paper, seafloor mounds have been imaged in detail with multibeam echosounders and parametric sub-bottom profilers in the deep central area of the Canary Basin ( 350-550 km west off El Hierro Island) between 4800 and 5200 mbsl. These features have circular to elongated shapes with heights of 10 to 250 m, diameters of 2-24 km and with flank slopes of 2-50°. Based on their morphological features and the subsurface structures these mounds have been classified into five different types of mounds that follow a linear correlation between height and slope but not between height and size. The first, second (Subgroup A), and third mound-types show heights lower than 80 m and maximum slopes of 35° with extension ranging from 2 to 400 km2 and correspond to domes formed at the surface created by intrusions located at depth that have not outcropped yet. The second (Subgroup B), fourth, and fifth mound-types show higher heights up to 250 m high, maximum slopes of 47° and sizes between 10 and 20 km2 and are related to the expulsion of hot and hydrothermal fluids and/or volcanics from extrusive deep-seated systems. Based on the constraints on their morphological and structural analyses, we suggest that morphostructural types of mounds are intimately linked to a specific origin that leaves its footprint in the morphology of the mounds. We propose a growth model for the five morphostructural types of mounds where different intrusive and extrusive phenomena represent the dominant mechanisms for mound growth evolution. These structures are also affected by tectonics (bulge-like structures clearly deformed by faulting) and mass movements (slide scars and mass transport deposits). In this work, we report how intrusive and extrusive processes may affect the seafloor morphology, identifying a new type of geomorphological feature as 'intrusive' domes that have, to date, only been reported in fossil environments but might extend to other oceanic areas.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fu, Li; Zhang, Yun; Wei, Zhehao

We report in this work detailed measurements on the chiral and achiral sum-frequency vibrational spectra in the C-H stretching vibration region (2800-3050cm-1) of the air/liquid interfaces of R-limonene and S-limonene, using the recently developed high-resolution broadband sum-frequency generation vibrational spectroscopy (HR-BB-SFG-VS). The achiral SFG spectra of R-limonene and S-limonene, as well as the equal amount (50/50) racemic mixture show that the enantiomers are with the same interfacial orientations. The interference chiral SFG spectra of the limonene enantiomers exhibit spectral signature from chiral response of the Cα-H stretching mode, and spectral signature from prochiral response of the CH2 asymmetric stretching mode,more » respectively. The chiral spectral feature of the Cα-H stretching mode changes sign from R-limonene to S-limonene, and disappears for the 50/50 racemic mixture. While the prochiral spectral feature of the CH2 asymmetric stretching mode is the same for R-limonene and S-limonene, and also surprisingly remains the same for the 50/50 racemic mixture. These results provided detail information in understanding the structure and chirality of molecular interfaces, and demonstrated the sensitivity and potential of SFG-VS as unique spectroscopic tool for chirality characterization and chiral recognition at the molecular interface.« less

Infrared Spectroscopy of Hydrogen in Fullerite and MOF-5 Hosts

NASA Astrophysics Data System (ADS)

Fitzgerald, Stephen; Churchill, Hugh; Korngut, Phil; Simmons, Christie; Strangas, Yorgos

2006-03-01

We present a novel use of diffuse reflectance infrared spectroscopy to study the quantum dynamics of hydrogen molecules trapped within a host material. This technique is particularly useful for the study of hydrogen storage materials since it provides detailed information about the intermolecular potential at the binding site. Because H2 has no intrinsic infrared activity any observed features arise solely through interaction with the host material and as such are very sensitive to the symmetry of the binding site. The drawback is that the induced spectra are quite weak. However, a technique based on diffuse reflectance has been shown to produce a sufficiently large signal [1]. We have now constructed a cryogenic system that allows spectra to be obtained in this manner at pressures as high as 100 atm. and at temperatures as low as 10 K. Data will be presented for H2 in both C60 and MOF-5 showing a series of absorption features arising from the quantized vibrational, rotational, and translational motion of the trapped H2. At the lowest temperature these peaks become quite sharp, FWHM less than 1 cm-1, with a detailed fine structure arising from the H2 host interactions. 1. S. A. FitzGerald et al., Phys. Rev. B 65, 140302. (2002)

Electron elastic scattering off endo-fullerenes

NASA Astrophysics Data System (ADS)

Dolmatov, Valeriy

2017-04-01

The given presentation highlights the physically transparent, relatively simple, and yet reasonably complete approximation to the problem of low-energy electron elastic scattering off endohedral fullerenes A@CN along with corresponding findings unraveled on its basis. It is believed that, as of today, the highlighted results provide the most complete information about features of e + A @CN elastic scattering brought about by the fullerene-cage-related, correlation-related, and polarization-related impacts of the individual and coupled members of the A@C60 target on the scattering process. Each of the impacts is shown to bring spectacular features into e + A @C60 scattering. A remarkable inherent quality of the developed approximation is its ability to account for mutual coupling between electronic excited configurations of CN with those of the encapsulated atom A without reference to complicated details of the electronic structure of CN itself. Spectacular effects in the scattering process, primarily associated with polarization of A@C60 by an incident electron, are thoughtfully detailed both quantitatively and qualitatively in a physically transparent manner for ease of understanding and convenience of the audience. This study was performed in collaboration with Professors M. Ya. Amusia, L. V. Chernysheva, and UNA undergraduate students. The past support by the NSF Grant PHY-1305085 is acknowledged.

Sulfur extended asphalt pavement evaluation in the State of Washington: SR 270 highway pavement performance report

NASA Astrophysics Data System (ADS)

Mahoney, J. P.; Terrel, R. L.; Cook, J. C.

1982-11-01

The placement and performance of sulfur extended asphalt (SEA) paving mixtures at a highway test site (SR 270) near Pullman, Washington is summarized. The mixture and structural designs and construction details are included. This is followed by a discussion of the data collection and analysis accomplished over a three year evaluation period (1979-1982). A major experimental feature of the study was the use of 0.100 (conventional asphalt concrete), 30/70 and 40/60 SEA binder ratios (sulfur/asphalt ratios are expressed as weight percents in the experimental paving mixtures.

Real-Time Multiprocessor Programming Language (RTMPL) user's manual

NASA Technical Reports Server (NTRS)

Arpasi, D. J.

1985-01-01

A real-time multiprocessor programming language (RTMPL) has been developed to provide for high-order programming of real-time simulations on systems of distributed computers. RTMPL is a structured, engineering-oriented language. The RTMPL utility supports a variety of multiprocessor configurations and types by generating assembly language programs according to user-specified targeting information. Many programming functions are assumed by the utility (e.g., data transfer and scaling) to reduce the programming chore. This manual describes RTMPL from a user's viewpoint. Source generation, applications, utility operation, and utility output are detailed. An example simulation is generated to illustrate many RTMPL features.

Artifacts in magnetic spirals retrieved by transport of intensity equation (TIE)

NASA Astrophysics Data System (ADS)

Cui, J.; Yao, Y.; Shen, X.; Wang, Y. G.; Yu, R. C.

2018-05-01

The artifacts in the magnetic structures reconstructed from Lorentz transmission electron microscopy (LTEM) images with TIE method have been analyzed in detail. The processing for the simulated images of Bloch and Neel spirals indicated that the improper parameters in TIE may overestimate the high frequency information and induce some false features in the retrieved images. The specimen tilting will further complicate the analysis of the images because the LTEM image contrast is not the result of the magnetization distribution within the specimen but the integral projection pattern of the magnetic induction filling the entire space including the specimen.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Livescu, Veronica; Bronkhorst, Curt Allan; Vander Wiel, Scott Alan

Many challenges exist with regard to understanding and representing complex physical processes involved with ductile damage and failure in polycrystalline metallic materials. Currently, the ability to accurately predict the macroscale ductile damage and failure response of metallic materials is lacking. Research at Los Alamos National Laboratory (LANL) is aimed at building a coupled experimental and computational methodology that supports the development of predictive damage capabilities by: capturing real distributions of microstructural features from real material and implementing them as digitally generated microstructures in damage model development; and, distilling structure-property information to link microstructural details to damage evolution under a multitudemore » of loading states.« less

The 13C nuclear magnetic resonance in graphite intercalation compounds

NASA Technical Reports Server (NTRS)

Tsang, T.; Resing, H. A.

1985-01-01

The (13)C NMR chemical shifts of graphite intercalation compounds were calculated. For acceptor types, the shifts come mainly from the paramagnetic (Ramsey) intra-atomic terms. They are related to the gross features of the two-dimensional band structures. The calculated anisotropy is about -140 ppm and is independent of the finer details such as charge transfer. For donor types, the carbon 2p pi orbitals are spin-polarized because of mixing with metal conduction electrons, thus there is an additional dipolar contribution which may be correlated with the electronic specific heat. The general agreement with experimental data is satisfactory.

Polyglutamine aggregation in Huntington and related diseases.

PubMed

Polling, Saskia; Hill, Andrew F; Hatters, Danny M

2012-01-01

Polyglutamine (polyQ)-expansions in different proteins cause nine neurodegenerative diseases. While polyQ aggregation is a key pathological hallmark of these diseases, how aggregation relates to pathogenesis remains contentious. In this chapter, we review what is known about the aggregation process and how cells respond and interact with the polyQ-expanded proteins. We cover detailed biophysical and structural studies to uncover the intrinsic features of polyQ aggregates and concomitant effects in the cellular environment. We also examine the functional consequences ofpolyQ aggregation and how cells may attempt to intervene and guide the aggregation process.