Science.gov

Sample records for detector decoy quantum

  1. Detector decoy quantum key distribution

    NASA Astrophysics Data System (ADS)

    Moroder, Tobias; Curty, Marcos; Lütkenhaus, Norbert

    2009-04-01

    Photon number resolving detectors can enhance the performance of many practical quantum cryptographic setups. In this paper, we employ a simple method to estimate the statistics provided by such a photon number resolving detector using only a threshold detector together with a variable attenuator. This idea is similar in spirit to that of the decoy state technique, and is especially suited to those scenarios where only a few parameters of the photon number statistics of the incoming signals have to be estimated. As an illustration of the potential applicability of the method in quantum communication protocols, we use it to prove security of an entanglement-based quantum key distribution scheme with an untrusted source without the need for a squash model and by solely using this extra idea. In this sense, this detector decoy method can be seen as a different conceptual approach to adapt a single-photon security proof to its physical, full optical implementation. We show that in this scenario, the legitimate users can now even discard the double click events from the raw key data without compromising the security of the scheme, and we present simulations on the performance of the BB84 and the 6-state quantum key distribution protocols.

  2. Detector-decoy high-dimensional quantum key distribution.

    PubMed

    Bao, Haize; Bao, Wansu; Wang, Yang; Chen, Ruike; Zhou, Chun; Jiang, Musheng; Li, Hongwei

    2016-09-19

    The decoy-state high-dimensional quantum key distribution provides a practical secure way to share more private information with high photon-information efficiency. In this paper, based on detector-decoy method, we propose a detector-decoy high-dimensional quantum key distribution protocol. Employing threshold detectors and a variable attenuator, we can promise the security under Gsussian collective attacks with much simpler operations in practical implementation. By numerical evaluation, we show that without varying the source intensity, our protocol performs much better than one-decoy-state protocol and as well as the two-decoy-state protocol in the infinite-size regime. In the finite-size regime, our protocol can achieve better results. Specially, when the detector efficiency is lower, the advantage of the detector-decoy method becomes more prominent. PMID:27661950

  3. Practical attacks on decoy-state quantum-key-distribution systems with detector efficiency mismatch

    NASA Astrophysics Data System (ADS)

    Fei, Yangyang; Gao, Ming; Wang, Weilong; Li, Chaobo; Ma, Zhi

    2015-05-01

    To the active-basis-choice decoy-state quantum-key-distribution systems with detector efficiency mismatch, we present a modified attack strategy, which is based on the faked states attack, with quantum nondemolition measurement ability to restress the threat of detector efficiency mismatch. Considering that perfect quantum nondemolition measurement ability doesn't exist in real life, we also propose a practical attack strategy using photon number resolving detectors. Theoretical analysis and numerical simulation results show that, without changing the channel, our attack strategies are serious threats to decoy-state quantum-key-distribution systems. The eavesdropper may get some information about the secret key without causing any alarms. Besides, the lower bound of detector efficiency mismatch to run our modified faked states attack successfully with perfect quantum nondemolition measurement ability is also given out, which provides the producers of quantum-key-distribution systems with a reference and can be treated as the approximate secure bound of detector efficiency mismatch in decoy-state quantum-key-distribution systems.

  4. Decoy State Quantum Key Distribution

    NASA Astrophysics Data System (ADS)

    Lo, Hoi-Kwong

    2005-10-01

    Quantum key distribution (QKD) allows two parties to communicate in absolute security based on the fundamental laws of physics. Up till now, it is widely believed that unconditionally secure QKD based on standard Bennett-Brassard (BB84) protocol is limited in both key generation rate and distance because of imperfect devices. Here, we solve these two problems directly by presenting new protocols that are feasible with only current technology. Surprisingly, our new protocols can make fiber-based QKD unconditionally secure at distances over 100km (for some experiments, such as GYS) and increase the key generation rate from O(η2) in prior art to O(η) where η is the overall transmittance. Our method is to develop the decoy state idea (first proposed by W.-Y. Hwang in "Quantum Key Distribution with High Loss: Toward Global Secure Communication", Phys. Rev. Lett. 91, 057901 (2003)) and consider simple extensions of the BB84 protocol. This part of work is published in "Decoy State Quantum Key Distribution", . We present a general theory of the decoy state protocol and propose a decoy method based on only one signal state and two decoy states. We perform optimization on the choice of intensities of the signal state and the two decoy states. Our result shows that a decoy state protocol with only two types of decoy states--a vacuum and a weak decoy state--asymptotically approaches the theoretical limit of the most general type of decoy state protocols (with an infinite number of decoy states). We also present a one-decoy-state protocol as a special case of Vacuum+Weak decoy method. Moreover, we provide estimations on the effects of statistical fluctuations and suggest that, even for long distance (larger than 100km) QKD, our two-decoy-state protocol can be implemented with only a few hours of experimental data. In conclusion, decoy state quantum key distribution is highly practical. This part of work is

  5. Experimental comparison between one-decoy and two-decoy implementations of the Bennett-Brassard 1984 quantum cryptography protocol

    NASA Astrophysics Data System (ADS)

    Jeong, Youn-Chang; Kim, Yong-Su; Kim, Yoon-Ho

    2016-01-01

    The decoy-state method allows the use of weak coherent pulses in quantum cryptography, and to date, various strategies for the decoy state have been proposed. Here, we experimentally compare the secret key generation rates between the one-decoy and two-decoy implementations of the Bennett-Brassard 1984 (BB84) quantum key distribution protocol through a 3.1-km optical fiber at 780 nm. Once the parameters of the experimental setup are optimized for the maximal secret key generation rate for each implementation, it is found that the two-decoy implementation outperforms the one-decoy implementation.

  6. Decoy state quantum key distribution with modified coherent state

    SciTech Connect

    Yin Zhenqiang; Han Zhengfu; Sun Fangwen; Guo Guangcan

    2007-07-15

    To beat photon-number splitting attack, decoy state quantum key distribution (QKD) based on the coherent state has been studied widely. We present a decoy state QKD protocol with a modified coherent state (MCS). By destructive quantum interference, a MCS with fewer multiphoton events can be obtained, which may improve the key bit rate and security distance of QKD. Through numerical simulation, we show about a 2-dB increment on the security distance for Bennett-Brassard (1984) protocol.

  7. Numerical analysis of decoy state quantum key distribution protocols

    SciTech Connect

    Harrington, Jim W; Rice, Patrick R

    2008-01-01

    Decoy state protocols are a useful tool for many quantum key distribution systems implemented with weak coherent pulses, allowing significantly better secret bit rates and longer maximum distances. In this paper we present a method to numerically find optimal three-level protocols, and we examine how the secret bit rate and the optimized parameters are dependent on various system properties, such as session length, transmission loss, and visibility. Additionally, we show how to modify the decoy state analysis to handle partially distinguishable decoy states as well as uncertainty in the prepared intensities.

  8. Passive decoy-state quantum key distribution with practical light sources

    SciTech Connect

    Curty, Marcos; Ma, Xiongfeng; Qi, Bing; Moroder, Tobias

    2010-02-15

    Decoy states have been proven to be a very useful method for significantly enhancing the performance of quantum key distribution systems with practical light sources. Although active modulation of the intensity of the laser pulses is an effective way of preparing decoy states in principle, in practice passive preparation might be desirable in some scenarios. Typical passive schemes involve parametric down-conversion. More recently, it has been shown that phase-randomized weak coherent pulses (WCP) can also be used for the same purpose [M. Curty et al., Opt. Lett. 34, 3238 (2009).] This proposal requires only linear optics together with a simple threshold photon detector, which shows the practical feasibility of the method. Most importantly, the resulting secret key rate is comparable to the one delivered by an active decoy-state setup with an infinite number of decoy settings. In this article we extend these results, now showing specifically the analysis for other practical scenarios with different light sources and photodetectors. In particular, we consider sources emitting thermal states, phase-randomized WCP, and strong coherent light in combination with several types of photodetectors, like, for instance, threshold photon detectors, photon number resolving detectors, and classical photodetectors. Our analysis includes as well the effect that detection inefficiencies and noise in the form of dark counts shown by current threshold detectors might have on the final secret key rate. Moreover, we provide estimations on the effects that statistical fluctuations due to a finite data size can have in practical implementations.

  9. Decoy-state quantum key distribution using homodyne detection

    NASA Astrophysics Data System (ADS)

    Shams Mousavi, S. H.; Gallion, P.

    2009-07-01

    In this paper, we propose to use the decoy-state technique to improve the security of the quantum key distribution (QKD) systems based on homodyne detection against the photon number splitting attack. The decoy-state technique is a powerful tool that can significantly boost the secure transmission range of the QKD systems. However, it has not yet been applied to the systems that use homodyne detection. After adapting this theory to the systems based on homodyne detection, we quantify the secure performance and transmission range of the resulting system.

  10. Decoy-state quantum key distribution with biased basis choice

    PubMed Central

    Wei, Zhengchao; Wang, Weilong; Zhang, Zhen; Gao, Ming; Ma, Zhi; Ma, Xiongfeng

    2013-01-01

    We propose a quantum key distribution scheme that combines a biased basis choice with the decoy-state method. In this scheme, Alice sends all signal states in the Z basis and decoy states in the X and Z basis with certain probabilities, and Bob measures received pulses with optimal basis choice. This scheme simplifies the system and reduces the random number consumption. From the simulation result taking into account of statistical fluctuations, we find that in a typical experimental setup, the proposed scheme can increase the key rate by at least 45% comparing to the standard decoy-state scheme. In the postprocessing, we also apply a rigorous method to upper bound the phase error rate of the single-photon components of signal states. PMID:23948999

  11. Experimental demonstration of passive-decoy-state quantum key distribution with two independent lasers

    NASA Astrophysics Data System (ADS)

    Sun, Shi-Hai; Tang, Guang-Zhao; Li, Chun-Yan; Liang, Lin-Mei

    2016-09-01

    The decoy-state method could effectively enhance the performance of quantum key distribution (QKD) with a practical phase randomized weak coherent source. Although active modulation of the source intensity is effective and has been implemented in many experiments, passive preparation of decoy states is also an important addition to the family of decoy-state QKD protocols. In this paper, following the theory of Curty et al. [Phys. Rev. A 81, 022310 (2010), 10.1103/PhysRevA.81.022310], we experimentally demonstrate the phase-encoding passive-decoy-state QKD with only linear optical setups and threshold single-photon detectors. In our experiment, two homemade independent pulsed lasers, with visibility of Hong-Ou-Mandel interference 0.53 (±0.003 ) , have been implemented and used to passively generate the different decoy states. Finally, a secret key rate of 1.5 ×10-5 /pulse is obtained with 10-km commercial fiber between Alice and Bob.

  12. An improved scheme on decoy-state method for measurement-device-independent quantum key distribution

    PubMed Central

    Wang, Dong; Li, Mo; Guo, Guang-Can; Wang, Qin

    2015-01-01

    Quantum key distribution involving decoy-states is a significant application of quantum information. By using three-intensity decoy-states of single-photon-added coherent sources, we propose a practically realizable scheme on quantum key distribution which approaches very closely the ideal asymptotic case of an infinite number of decoy-states. We make a comparative study between this scheme and two other existing ones, i.e., two-intensity decoy-states with single-photon-added coherent sources, and three-intensity decoy-states with weak coherent sources. Through numerical analysis, we demonstrate the advantages of our scheme in secure transmission distance and the final key generation rate. PMID:26463580

  13. Implementation of decoy states in a subcarrier wave quantum key distribution system

    NASA Astrophysics Data System (ADS)

    Gaidash, A.; Kozubov, A.; Egorov, V.; Gleim, A.

    2016-08-01

    Subcarrier wave quantum key distribution systems demonstrate promising capabilities for secure quantum networking. However for this class of devices no implementation of secure decoy states protocol was developed. It leaves them potentially vulnerable to photon-number splitting attacks on quantum channel and limiting the key distribution distance. We propose a practical solution to this problem by calculating the required parameters of light source and modulation indices for signal and decoy states in a subcarrier wave system and describing the corresponding experimental scheme.

  14. The enhanced measurement-device-independent quantum key distribution with two-intensity decoy states

    NASA Astrophysics Data System (ADS)

    Zhu, Jian-Rong; Zhu, Feng; Zhou, Xing-Yu; Wang, Qin

    2016-09-01

    We put forward a new scheme for implementing the measurement-device-independent quantum key distribution (QKD) with weak coherent source, while using only two different intensities. In the new scheme, we insert a beam splitter and a local detector at both Alice's and Bob's side, and then all the triggering and non-triggering signals could be employed to process parameter estimations, resulting in very precise estimations for the two-single-photon contributions. Besides, we compare its behavior with two other often used methods, i.e., the conventional standard three-intensity decoy-state measurement-device-independent QKD and the passive measurement-device-independent QKD. Through numerical simulations, we demonstrate that our new approach can exhibit outstanding characteristics not only in the secure transmission distance, but also in the final key generation rate.

  15. An enhanced proposal on decoy-state measurement device-independent quantum key distribution

    NASA Astrophysics Data System (ADS)

    Wang, Qin; Zhang, Chun-Hui; Luo, Shunlong; Guo, Guang-Can

    2016-09-01

    By employing pulses involving three-intensity, we propose a scheme for the measurement device-independent quantum key distribution with heralded single-photon sources. We make a comparative study of this scheme with the standard three-intensity decoy-state scheme using weak coherent sources or heralded single-photon sources. The advantage of this scheme is illustrated through numerical simulations: It can approach very closely the asymptotic case of using an infinite number of decoy-states and exhibits excellent behavior in both the secure transmission distance and the final key generation rate.

  16. Quantum secure direct communication network with superdense coding and decoy photons

    NASA Astrophysics Data System (ADS)

    Deng, Fu-Guo; Li, Xi-Han; Li, Chun-Yan; Zhou, Ping; Zhou, Hong-Yu

    2007-07-01

    A quantum secure direct communication network scheme is proposed with quantum superdense coding and decoy photons. The servers on a passive optical network prepare and measure the quantum signal, i.e. a sequence of the d-dimensional Bell states. After confirming the security of the photons received from the receiver, the sender codes his secret message on them directly. For preventing a dishonest server from eavesdropping, some decoy photons prepared by measuring one photon in the Bell states are used to replace some original photons. One of the users on the network can communicate to any other one. This scheme has the advantage of high capacity, and it is more convenient than others as only a sequence of photons is transmitted in quantum line.

  17. Field test of a practical secure communication network with decoy-state quantum cryptography.

    PubMed

    Chen, Teng-Yun; Liang, Hao; Liu, Yang; Cai, Wen-Qi; Ju, Lei; Liu, Wei-Yue; Wang, Jian; Yin, Hao; Chen, Kai; Chen, Zeng-Bing; Peng, Cheng-Zhi; Pan, Jian-Wei

    2009-04-13

    We present a secure network communication system that operated with decoy-state quantum cryptography in a real-world application scenario. The full key exchange and application protocols were performed in real time among three nodes, in which two adjacent nodes were connected by approximate 20 km of commercial telecom optical fiber. The generated quantum keys were immediately employed and demonstrated for communication applications, including unbreakable real-time voice telephone between any two of the three communication nodes, or a broadcast from one node to the other two nodes by using one-time pad encryption.

  18. Field test of a practical secure communication network with decoy-state quantum cryptography.

    PubMed

    Chen, Teng-Yun; Liang, Hao; Liu, Yang; Cai, Wen-Qi; Ju, Lei; Liu, Wei-Yue; Wang, Jian; Yin, Hao; Chen, Kai; Chen, Zeng-Bing; Peng, Cheng-Zhi; Pan, Jian-Wei

    2009-04-13

    We present a secure network communication system that operated with decoy-state quantum cryptography in a real-world application scenario. The full key exchange and application protocols were performed in real time among three nodes, in which two adjacent nodes were connected by approximate 20 km of commercial telecom optical fiber. The generated quantum keys were immediately employed and demonstrated for communication applications, including unbreakable real-time voice telephone between any two of the three communication nodes, or a broadcast from one node to the other two nodes by using one-time pad encryption. PMID:19365479

  19. Quantum key distribution with dual detectors

    SciTech Connect

    Qi, Bing; Zhao, Yi; Ma, Xiongfeng; Lo, Hoi-Kwong; Qian, Li

    2007-05-15

    To improve the performance of a quantum-key-distribution (QKD) system, high speed, low dark count single photon detectors (or low-noise homodyne detectors) are required. However, in practice, a fast detector is usually noisy. Here, we propose a dual-detector method to improve the performance of a practical QKD system with realistic detectors: the legitimate receiver randomly uses either a fast (but noisy) detector or a quiet (but slow) detector to measure the incoming quantum signals. The measurement results from the quiet detector can be used to bound the eavesdropper's information, while the measurement results from the fast detector are used to generate a secure key. We apply this idea to various QKD protocols. Simulation results demonstrate significant improvements of the secure key rate in the lower loss regime in both Bennett-Brassard 1984 (BB84) protocol with ideal single photon source and Gaussian-modulated coherent states protocol; while for decoy-state BB84 protocol with weak coherent source, the improvement is moderate. We also discuss various practical issues in implementing the dual-detector scheme.

  20. Decoy-state quantum key distribution with a leaky source

    NASA Astrophysics Data System (ADS)

    Tamaki, Kiyoshi; Curty, Marcos; Lucamarini, Marco

    2016-06-01

    In recent years, there has been a great effort to prove the security of quantum key distribution (QKD) with a minimum number of assumptions. Besides its intrinsic theoretical interest, this would allow for larger tolerance against device imperfections in the actual implementations. However, even in this device-independent scenario, one assumption seems unavoidable, that is, the presence of a protected space devoid of any unwanted information leakage in which the legitimate parties can privately generate, process and store their classical data. In this paper we relax this unrealistic and hardly feasible assumption and introduce a general formalism to tackle the information leakage problem in most of existing QKD systems. More specifically, we prove the security of optical QKD systems using phase and intensity modulators in their transmitters, which leak the setting information in an arbitrary manner. We apply our security proof to cases of practical interest and show key rates similar to those obtained in a perfectly shielded environment. Our work constitutes a fundamental step forward in guaranteeing implementation security of quantum communication systems.

  1. Experimental Demonstration of Free-Space Decoy-State Quantum Key Distribution over 144km

    NASA Astrophysics Data System (ADS)

    Schmitt-Manderbach, Tobias; Weier, Henning; Fürst, Martin; Ursin, Rupert; Tiefenbacher, Felix; Scheidl, Thomas; Perdigues, Josep; Sodnik, Zoran; Kurtsiefer, Christian; Rarity, John G.; Zeilinger, Anton; Weinfurter, Harald

    2007-01-01

    We report on the experimental implementation of a Bennett-Brassard 1984 (BB84) protocol type quantum key distribution over a 144 km free-space link using weak coherent laser pulses. Optimization of the link transmission was achieved with bidirectional active telescope tracking, and the security was ensured by employing decoy-state analysis. This enabled us to distribute a secure key at a rate of 12.8bit/s at an attenuation of about 35 dB. Utilizing a simple transmitter setup and an optical ground station capable of tracking a spacecraft in low earth orbit, this outdoor experiment demonstrates the feasibility of global key distribution via satellites.

  2. Hacking on decoy-state quantum key distribution system with partial phase randomization.

    PubMed

    Sun, Shi-Hai; Jiang, Mu-Sheng; Ma, Xiang-Chun; Li, Chun-Yan; Liang, Lin-Mei

    2014-01-01

    Quantum key distribution (QKD) provides means for unconditional secure key transmission between two distant parties. However, in practical implementations, it suffers from quantum hacking due to device imperfections. Here we propose a hybrid measurement attack, with only linear optics, homodyne detection, and single photon detection, to the widely used vacuum + weak decoy state QKD system when the phase of source is partially randomized. Our analysis shows that, in some parameter regimes, the proposed attack would result in an entanglement breaking channel but still be able to trick the legitimate users to believe they have transmitted secure keys. That is, the eavesdropper is able to steal all the key information without discovered by the users. Thus, our proposal reveals that partial phase randomization is not sufficient to guarantee the security of phase-encoding QKD systems with weak coherent states. PMID:24755767

  3. Hacking on decoy-state quantum key distribution system with partial phase randomization.

    PubMed

    Sun, Shi-Hai; Jiang, Mu-Sheng; Ma, Xiang-Chun; Li, Chun-Yan; Liang, Lin-Mei

    2014-04-23

    Quantum key distribution (QKD) provides means for unconditional secure key transmission between two distant parties. However, in practical implementations, it suffers from quantum hacking due to device imperfections. Here we propose a hybrid measurement attack, with only linear optics, homodyne detection, and single photon detection, to the widely used vacuum + weak decoy state QKD system when the phase of source is partially randomized. Our analysis shows that, in some parameter regimes, the proposed attack would result in an entanglement breaking channel but still be able to trick the legitimate users to believe they have transmitted secure keys. That is, the eavesdropper is able to steal all the key information without discovered by the users. Thus, our proposal reveals that partial phase randomization is not sufficient to guarantee the security of phase-encoding QKD systems with weak coherent states.

  4. Hacking on decoy-state quantum key distribution system with partial phase randomization

    NASA Astrophysics Data System (ADS)

    Sun, Shi-Hai; Jiang, Mu-Sheng; Ma, Xiang-Chun; Li, Chun-Yan; Liang, Lin-Mei

    2014-04-01

    Quantum key distribution (QKD) provides means for unconditional secure key transmission between two distant parties. However, in practical implementations, it suffers from quantum hacking due to device imperfections. Here we propose a hybrid measurement attack, with only linear optics, homodyne detection, and single photon detection, to the widely used vacuum + weak decoy state QKD system when the phase of source is partially randomized. Our analysis shows that, in some parameter regimes, the proposed attack would result in an entanglement breaking channel but still be able to trick the legitimate users to believe they have transmitted secure keys. That is, the eavesdropper is able to steal all the key information without discovered by the users. Thus, our proposal reveals that partial phase randomization is not sufficient to guarantee the security of phase-encoding QKD systems with weak coherent states.

  5. Hacking on decoy-state quantum key distribution system with partial phase randomization

    PubMed Central

    Sun, Shi-Hai; Jiang, Mu-Sheng; Ma, Xiang-Chun; Li, Chun-Yan; Liang, Lin-Mei

    2014-01-01

    Quantum key distribution (QKD) provides means for unconditional secure key transmission between two distant parties. However, in practical implementations, it suffers from quantum hacking due to device imperfections. Here we propose a hybrid measurement attack, with only linear optics, homodyne detection, and single photon detection, to the widely used vacuum + weak decoy state QKD system when the phase of source is partially randomized. Our analysis shows that, in some parameter regimes, the proposed attack would result in an entanglement breaking channel but still be able to trick the legitimate users to believe they have transmitted secure keys. That is, the eavesdropper is able to steal all the key information without discovered by the users. Thus, our proposal reveals that partial phase randomization is not sufficient to guarantee the security of phase-encoding QKD systems with weak coherent states. PMID:24755767

  6. Experimental demonstration of free-space decoy-state quantum key distribution over 144 km.

    PubMed

    Schmitt-Manderbach, Tobias; Weier, Henning; Fürst, Martin; Ursin, Rupert; Tiefenbacher, Felix; Scheidl, Thomas; Perdigues, Josep; Sodnik, Zoran; Kurtsiefer, Christian; Rarity, John G; Zeilinger, Anton; Weinfurter, Harald

    2007-01-01

    We report on the experimental implementation of a Bennett-Brassard 1984 (BB84) protocol type quantum key distribution over a 144 km free-space link using weak coherent laser pulses. Optimization of the link transmission was achieved with bidirectional active telescope tracking, and the security was ensured by employing decoy-state analysis. This enabled us to distribute a secure key at a rate of 12.8 bit/s at an attenuation of about 35 dB. Utilizing a simple transmitter setup and an optical ground station capable of tracking a spacecraft in low earth orbit, this outdoor experiment demonstrates the feasibility of global key distribution via satellites. PMID:17358463

  7. Trustworthiness of detectors in quantum key distribution with untrusted detectors

    DOE PAGES

    Qi, Bing

    2015-02-25

    Measurement-device-independent quantum key distribution (MDI-QKD) protocol has been demonstrated as a viable solution to detector side-channel attacks. One of the main advantages of MDI-QKD is that the security can be proved without making any assumptions about how the measurement device works. The price to pay is the relatively low secure key rate comparing with conventional quantum key distribution (QKD), such as the decoy-state BB84 protocol. Recently a new QKD protocol, aiming at bridging the strong security of MDI-QKD with the high e ciency of conventional QKD, has been proposed. In this protocol, the legitimate receiver employs a trusted linear opticsmore » network to encode information on photons received from an insecure quantum channel, and then performs a Bell state measurement (BSM) using untrusted detectors. One crucial assumption made in most of these studies is that the untrusted BSM located inside the receiver's laboratory cannot send any unwanted information to the outside. Here in this paper, we show that if the BSM is completely untrusted, a simple scheme would allow the BSM to send information to the outside. Combined with Trojan horse attacks, this scheme could allow Eve to gain information of the quantum key without being detected. Ultimately, to prevent the above attack, either countermeasures to Trojan horse attacks or some trustworthiness to the "untrusted" BSM device is required.« less

  8. Trustworthiness of detectors in quantum key distribution with untrusted detectors

    SciTech Connect

    Qi, Bing

    2015-02-25

    Measurement-device-independent quantum key distribution (MDI-QKD) protocol has been demonstrated as a viable solution to detector side-channel attacks. One of the main advantages of MDI-QKD is that the security can be proved without making any assumptions about how the measurement device works. The price to pay is the relatively low secure key rate comparing with conventional quantum key distribution (QKD), such as the decoy-state BB84 protocol. Recently a new QKD protocol, aiming at bridging the strong security of MDI-QKD with the high e ciency of conventional QKD, has been proposed. In this protocol, the legitimate receiver employs a trusted linear optics network to encode information on photons received from an insecure quantum channel, and then performs a Bell state measurement (BSM) using untrusted detectors. One crucial assumption made in most of these studies is that the untrusted BSM located inside the receiver's laboratory cannot send any unwanted information to the outside. Here in this paper, we show that if the BSM is completely untrusted, a simple scheme would allow the BSM to send information to the outside. Combined with Trojan horse attacks, this scheme could allow Eve to gain information of the quantum key without being detected. Ultimately, to prevent the above attack, either countermeasures to Trojan horse attacks or some trustworthiness to the "untrusted" BSM device is required.

  9. Quantum Opportunities in Gravitational Wave Detectors

    SciTech Connect

    Mavalvala, Negris

    2012-03-14

    Direct observation of gravitational waves should open a new window into the Universe. Gravitational wave detectors are the most sensitive position meters ever constructed. The quantum limit in gravitational wave detectors opens up a whole new field of study. Quantum opportunities in gravitational wave detectors include applications of quantum optics techniques and new tools for quantum measurement on truly macroscopic (human) scales.

  10. Tunable quantum well infrared detector

    NASA Technical Reports Server (NTRS)

    Maserjian, Joseph (Inventor)

    1990-01-01

    A novel infrared detector (20, 20', 20), is provided, which is characterized by photon-assisted resonant tunneling between adjacent quantum wells (22a, 22b) separated by barrier layers (28) in an intrinsic semiconductor layer (24) formed on an n.sup.+ substrate (26), wherein the resonance is electrically tunable over a wide band of wavelengths in the near to long infrared region. An n.sup.+ contacting layer (34) is formed over the intrinsic layer and the substrate is n.sup.+ doped to provide contact to the quantum wells. The detector permits fabrication of arrays (30) (one-dimensional and two-dimensional) for use in imaging and spectroscopy applications.

  11. How to implement decoy-state quantum key distribution for a satellite uplink with 50-dB channel loss

    SciTech Connect

    Meyer-Scott, Evan; Yan, Zhizhong; MacDonald, Allison; Bourgoin, Jean-Philippe; Huebel, Hannes; Jennewein, Thomas

    2011-12-15

    Quantum key distribution (QKD) takes advantage of fundamental properties of quantum physics to allow two distant parties to share a secret key; however, QKD is hampered by a distance limitation of a few hundred kilometers on Earth. The most immediate solution for global coverage is to use a satellite, which can receive separate QKD transmissions from two or more ground stations and act as a trusted node to link these ground stations. In this article we report on a system capable of performing QKD in the high loss regime expected in an uplink to a satellite using weak coherent pulses and decoy states. Such a scenario profits from the simplicity of its receiver payload, but has so far been considered to be infeasible due to very high transmission losses (40-50 dB). The high loss is overcome by implementing an innovative photon source and advanced timing analysis. Our system handles up to 57 dB photon loss in the infinite key limit, confirming the viability of the satellite uplink scenario. We emphasize that while this system was designed with a satellite uplink in mind, it could just as easily overcome high losses on any free space QKD link.

  12. Free-space measurement-device-independent quantum-key-distribution protocol using decoy states with orbital angular momentum

    NASA Astrophysics Data System (ADS)

    Wang, Le; Zhao, Sheng-Mei; Gong, Long-Yan; Cheng, Wei-Wen

    2015-12-01

    In this paper, we propose a measurement-device-independent quantum-key-distribution (MDI-QKD) protocol using orbital angular momentum (OAM) in free space links, named the OAM-MDI-QKD protocol. In the proposed protocol, the OAM states of photons, instead of polarization states, are used as the information carriers to avoid the reference frame alignment, the decoy-state is adopted to overcome the security loophole caused by the weak coherent pulse source, and the high efficient OAM-sorter is adopted as the measurement tool for Charlie to obtain the output OAM state. Here, Charlie may be an untrusted third party. The results show that the authorized users, Alice and Bob, could distill a secret key with Charlie’s successful measurements, and the key generation performance is slightly better than that of the polarization-based MDI-QKD protocol in the two-dimensional OAM cases. Simultaneously, Alice and Bob can reduce the number of flipping the bits in the secure key distillation. It is indicated that a higher key generation rate performance could be obtained by a high dimensional OAM-MDI-QKD protocol because of the unlimited degree of freedom on OAM states. Moreover, the results show that the key generation rate and the transmission distance will decrease as the growth of the strength of atmospheric turbulence (AT) and the link attenuation. In addition, the decoy states used in the proposed protocol can get a considerable good performance without the need for an ideal source. Project supported by the National Natural Science Foundation of China (Grant Nos. 61271238 and 61475075), the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20123223110003), the Natural Science Research Foundation for Universities of Jiangsu Province of China (Grant No. 11KJA510002), the Open Research Fund of Key Laboratory of Broadband Wireless Communication and Sensor Network Technology, Ministry of Education, China (Grant No. NYKL2015011), and the

  13. Security issues of quantum cryptographic systems with imperfect detectors

    NASA Astrophysics Data System (ADS)

    Burenkov, Viacheslav

    The laws of quantum physics can be used to secure communications between two distant parties in a scheme called quantum key distribution (QKD), even against a technologically unlimited eavesdropper. While the theoretical security of QKD has been proved rigorously, current implementations of QKD are generally insecure. In particular, mathematical models of devices, such as detectors, do not accurately describe their real-life behaviour. Such seemingly insignificant discrepancies can compromise the security of the entire scheme, especially as novel detector technologies are being developed with little regard for potential vulnerabilities. In this thesis, we study how detector imperfections can impact the security of QKD and how to overcome such technological limitations. We first analyze the security of a high-speed QKD system with finite detector dead time tau. We show that the previously reported sifting approaches are not guaranteed to be secure in this regime. More specifically, Eve can induce a basis-dependent detection efficiency at the receiver's end. Modified key sifting schemes that are basis-independent, and thus secure in the presence of dead time and an active eavesdropper, are discussed and compared. It is shown that the maximum key generation rate is 1/(2tau) for passive basis selection, and 1/tau for active basis selection. The security analysis is also extended to the decoy state BB84 protocol. We then study a relatively new type of single-photon detector called the superconducting nanowire single-photon detector (SNSPD), and discover some unexpected behaviour. We report an afterpulsing effect present when the SNSPD is operated in the high bias current regime. In our standard set-up, the afterpulsing is most likely to occur at around 180 ns following a detection event, for both real counts and dark counts. We characterize the afterpulsing behaviour and speculate that it is not due to the SNSPD itself but rather the associated read-out circuit. We also

  14. Upper bounds of eavesdropper's performances in finite-length code with the decoy method

    SciTech Connect

    Hayashi, Masahito

    2007-07-15

    Security formulas of quantum key distribution (QKD) with imperfect resources are obtained for finite-length code when the decoy method is applied. This analysis is useful for guaranteeing the security of implemented QKD systems. Our formulas take into account the effect of the vacuum state and dark counts in the detector. We compare the asymptotic key generation rate in the presence of dark counts to that without the presence of dark counts.

  15. Superlinear threshold detectors in quantum cryptography

    NASA Astrophysics Data System (ADS)

    Lydersen, Lars; Jain, Nitin; Wittmann, Christoffer; Marøy, Øystein; Skaar, Johannes; Marquardt, Christoph; Makarov, Vadim; Leuchs, Gerd

    2011-09-01

    We introduce the concept of a superlinear threshold detector, a detector that has a higher probability to detect multiple photons if it receives them simultaneously rather than at separate times. Highly superlinear threshold detectors in quantum key distribution systems allow eavesdropping the full secret key without being revealed. Here, we generalize the detector control attack, and analyze how it performs against quantum key distribution systems with moderately superlinear detectors. We quantify the superlinearity in superconducting single-photon detectors based on earlier published data, and gated avalanche photodiode detectors based on our own measurements. The analysis shows that quantum key distribution systems using detector(s) of either type can be vulnerable to eavesdropping. The avalanche photodiode detector becomes superlinear toward the end of the gate. For systems expecting substantial loss, or for systems not monitoring loss, this would allow eavesdropping using trigger pulses containing less than 120 photons per pulse. Such an attack would be virtually impossible to catch with an optical power meter at the receiver entrance.

  16. Superlinear threshold detectors in quantum cryptography

    SciTech Connect

    Lydersen, Lars; Maroey, Oystein; Skaar, Johannes; Makarov, Vadim; Jain, Nitin; Wittmann, Christoffer; Marquardt, Christoph; Leuchs, Gerd

    2011-09-15

    We introduce the concept of a superlinear threshold detector, a detector that has a higher probability to detect multiple photons if it receives them simultaneously rather than at separate times. Highly superlinear threshold detectors in quantum key distribution systems allow eavesdropping the full secret key without being revealed. Here, we generalize the detector control attack, and analyze how it performs against quantum key distribution systems with moderately superlinear detectors. We quantify the superlinearity in superconducting single-photon detectors based on earlier published data, and gated avalanche photodiode detectors based on our own measurements. The analysis shows that quantum key distribution systems using detector(s) of either type can be vulnerable to eavesdropping. The avalanche photodiode detector becomes superlinear toward the end of the gate. For systems expecting substantial loss, or for systems not monitoring loss, this would allow eavesdropping using trigger pulses containing less than 120 photons per pulse. Such an attack would be virtually impossible to catch with an optical power meter at the receiver entrance.

  17. The Quantasyn, an improved quantum detector

    NASA Technical Reports Server (NTRS)

    Gorstein, M.; Mc Williams, I. G.; Seward, H. H.

    1969-01-01

    Quantasyn provides absolute measurement of radiation flux in the range 1000 A to 4500 A and into the vacuum ultraviolet. This radiation detector cimbines the high quantum efficiency and inherent linearity of the silicon solar cell with the constant quantum response of the fluorescent organic compound liumogen.

  18. Photonic crystal slab quantum cascade detector

    NASA Astrophysics Data System (ADS)

    Reininger, Peter; Schwarz, Benedikt; Harrer, Andreas; Zederbauer, Tobias; Detz, Hermann; Maxwell Andrews, Aaron; Gansch, Roman; Schrenk, Werner; Strasser, Gottfried

    2013-12-01

    In this Letter, we demonstrate the design, fabrication, and characterization of a photonic crystal slab quantum cascade detector (PCS-QCD). By employing a specifically designed resonant cavity, the performance of the photodetector is improved in three distinct ways. The PCS makes the QCD sensitive to surface normal incident light. It resonantly enhances the photon lifetime inside the active zone, thus increasing the photocurrent significantly. And, the construction form of the device inherently decreases the noise. Finally, we compare the characteristics of the PCS-QCD to a PCS - quantum well infrared photodetector and outline the advantages for certain fields of applications.

  19. Photonic crystal slab quantum cascade detector

    SciTech Connect

    Reininger, Peter Schwarz, Benedikt; Harrer, Andreas; Zederbauer, Tobias; Detz, Hermann; Maxwell Andrews, Aaron; Gansch, Roman; Schrenk, Werner; Strasser, Gottfried

    2013-12-09

    In this Letter, we demonstrate the design, fabrication, and characterization of a photonic crystal slab quantum cascade detector (PCS-QCD). By employing a specifically designed resonant cavity, the performance of the photodetector is improved in three distinct ways. The PCS makes the QCD sensitive to surface normal incident light. It resonantly enhances the photon lifetime inside the active zone, thus increasing the photocurrent significantly. And, the construction form of the device inherently decreases the noise. Finally, we compare the characteristics of the PCS-QCD to a PCS - quantum well infrared photodetector and outline the advantages for certain fields of applications.

  20. Quantum metrology with imperfect states and detectors

    SciTech Connect

    Datta, Animesh; Zhang Lijian; Thomas-Peter, Nicholas; Smith, Brian J.; Walmsley, Ian A.; Dorner, Uwe

    2011-06-15

    Quantum enhancements of precision in metrology can be compromised by system imperfections. These may be mitigated by appropriate optimization of the input state to render it robust, at the expense of making the state difficult to prepare. In this paper, we identify the major sources of imperfection of an optical sensor: input state preparation inefficiency, sensor losses, and detector inefficiency. The second of these has received much attention; we show that it is the least damaging to surpassing the standard quantum limit in a optical interferometric sensor. Further, we show that photonic states that can be prepared in the laboratory using feasible resources allow a measurement strategy using photon-number-resolving detectors that not only attain the Heisenberg limit for phase estimation in the absence of losses, but also deliver close to the maximum possible precision in realistic scenarios including losses and inefficiencies. In particular, we give bounds for the tradeoff between the three sources of imperfection that will allow true quantum-enhanced optical metrology

  1. Quantum Efficient Detectors for Use in Absolute Calibration

    NASA Technical Reports Server (NTRS)

    Faust, Jessica; Eastwood, Michael; Pavri, Betina; Raney, James

    1998-01-01

    The trap or quantum efficient detector has a quantum efficiency of greater than 0.98 for the region from 450 to 900 nm. The region of flattest response is from 600 to 900 nm. The QED consists of three windowless Hamamatsu silicon detectors. The QED was mounted below AVIRIS to monitor the Spectralon panel for changes in radiance during radiometric calibration. The next step is to permanently mount the detector to AVIRIS and monitor the overall radiance of scenes along with calibration.

  2. Using quantum filters as edge detectors in infrared images

    NASA Astrophysics Data System (ADS)

    Bolaños Marín, Daniela

    2014-06-01

    Some new filters inspired in quantum models are used as edge detectors in infrared images. In this case, Bessel, Hermite and Morse filters will be applied to detect edges and fibrillar structures in infrared images. The edge detectors will be built by the Laplacian of the mentioned quantum filters. Furthermore, using curvature operators, curvature detectors and amplifiers of contrast will be constructed to analyze infrared images. The quantum filter prototyping will be done using computer algebra software, specifically Maple and its package, ImageTools. The quantum filters will be applied to infrared images using the technique of convolutions and blurred derivatives. It is expected that designed quantum filters will be useful for analysis and processing of infrared images. As future investigations, we propose to design plugins with the quantum filters that can be incorporated into the program ImageJ, which will facilitate the use of the quantum filters for the infrared image processing.

  3. Integrated superconducting detectors on semiconductors for quantum optics applications

    NASA Astrophysics Data System (ADS)

    Kaniber, M.; Flassig, F.; Reithmaier, G.; Gross, R.; Finley, J. J.

    2016-05-01

    Semiconductor quantum photonic circuits can be used to efficiently generate, manipulate, route and exploit nonclassical states of light for distributed photon-based quantum information technologies. In this article, we review our recent achievements on the growth, nanofabrication and integration of high-quality, superconducting niobium nitride thin films on optically active, semiconducting GaAs substrates and their patterning to realize highly efficient and ultra-fast superconducting detectors on semiconductor nanomaterials containing quantum dots. Our state-of-the-art detectors reach external detection quantum efficiencies up to 20 % for ~4 nm thin films and single-photon timing resolutions <72 ps. We discuss the integration of such detectors into quantum dot-loaded, semiconductor ridge waveguides, resulting in the on-chip, time-resolved detection of quantum dot luminescence. Furthermore, a prototype quantum optical circuit is demonstrated that enabled the on-chip generation of resonance fluorescence from an individual InGaAs quantum dot, with a linewidth <15 μeV displaced by 1 mm from the superconducting detector on the very same semiconductor chip. Thus, all key components required for prototype quantum photonic circuits with sources, optical components and detectors on the same chip are reported.

  4. Rate equation modelling and investigation of quantum cascade detector characteristics

    NASA Astrophysics Data System (ADS)

    Saha, Sumit; Kumar, Jitendra

    2016-10-01

    A simple precise transport model has been proposed using rate equation approach for the characterization of a quantum cascade detector. The resonant tunneling transport is incorporated in the rate equation model through a resonant tunneling current density term. All the major scattering processes are included in the rate equation model. The effect of temperature on the quantum cascade detector characteristics has been examined considering the temperature dependent band parameters and the carrier scattering processes. Incorporation of the resonant tunneling process in the rate equation model improves the detector performance appreciably and reproduces the detector characteristics within experimental accuracy.

  5. Quantum Well and Quantum Dot Modeling for Advanced Infrared Detectors and Focal Plane Arrays

    NASA Technical Reports Server (NTRS)

    Ting, David; Gunapala, S. D.; Bandara, S. V.; Hill, C. J.

    2006-01-01

    This viewgraph presentation reviews the modeling of Quantum Well Infrared Detectors (QWIP) and Quantum Dot Infrared Detectors (QDIP) in the development of Focal Plane Arrays (FPA). The QWIP Detector being developed is a dual band detector. It is capable of running on two bands Long-Wave Infrared (LWIR) and Medium Wavelength Infrared (MWIR). The same large-format dual-band FPA technology can be applied to Quantum Dot Infrared Photodetector (QDIP) with no modification, once QDIP exceeds QWIP in single device performance. Details of the devices are reviewed.

  6. Determination of the Quantum Efficiency of a Light Detector

    ERIC Educational Resources Information Center

    Kraftmakher, Yaakov

    2008-01-01

    The "quantum efficiency" (QE) is an important property of a light detector. This quantity can be determined in the undergraduate physics laboratory. The experimentally determined QE of a silicon photodiode appeared to be in reasonable agreement with expected values. The experiment confirms the quantum properties of light and seems to be a useful…

  7. Quantum key distribution over 120 km using ultrahigh purity single-photon source and superconducting single-photon detectors.

    PubMed

    Takemoto, Kazuya; Nambu, Yoshihiro; Miyazawa, Toshiyuki; Sakuma, Yoshiki; Yamamoto, Tsuyoshi; Yorozu, Shinichi; Arakawa, Yasuhiko

    2015-09-25

    Advances in single-photon sources (SPSs) and single-photon detectors (SPDs) promise unique applications in the field of quantum information technology. In this paper, we report long-distance quantum key distribution (QKD) by using state-of-the-art devices: a quantum-dot SPS (QD SPS) emitting a photon in the telecom band of 1.5 μm and a superconducting nanowire SPD (SNSPD). At the distance of 100 km, we obtained the maximal secure key rate of 27.6 bps without using decoy states, which is at least threefold larger than the rate obtained in the previously reported 50-km-long QKD experiment. We also succeeded in transmitting secure keys at the rate of 0.307 bps over 120 km. This is the longest QKD distance yet reported by using known true SPSs. The ultralow multiphoton emissions of our SPS and ultralow dark count of the SNSPD contributed to this result. The experimental results demonstrate the potential applicability of QD SPSs to practical telecom QKD networks.

  8. Plasmonic lens enhanced mid-infrared quantum cascade detector

    SciTech Connect

    Harrer, Andreas Schwarz, Benedikt; Gansch, Roman; Reininger, Peter; Detz, Hermann; Zederbauer, Tobias; Andrews, Aaron Maxwell; Schrenk, Werner; Strasser, Gottfried

    2014-10-27

    We demonstrate monolithic integrated quantum cascade detectors enhanced by plasmonic lenses. Surface normal incident mid-infrared radiation is coupled to surface plasmon polaritons guided to and detected by the active region of the detector. The lens extends the optical effective active area of the device up to a 5 times larger area than for standard mesa detectors or pixel devices while the electrical active region stays the same. The extended optical area increases the absorption efficiency of the presented device as well as the room temperature performance while it offers a flexible platform for various detector geometries. A photocurrent response increase at room temperature up to a factor of 6 was observed.

  9. Thermal blinding of gated detectors in quantum cryptography.

    PubMed

    Lydersen, Lars; Wiechers, Carlos; Wittmann, Christoffer; Elser, Dominique; Skaar, Johannes; Makarov, Vadim

    2010-12-20

    It has previously been shown that the gated detectors of two commercially available quantum key distribution (QKD) systems are blindable and controllable by an eavesdropper using continuous-wave illumination and short bright trigger pulses, manipulating voltages in the circuit [Nat. Photonics 4, 686 (2010)]. This allows for an attack eavesdropping the full raw and secret key without increasing the quantum bit error rate (QBER). Here we show how thermal effects in detectors under bright illumination can lead to the same outcome. We demonstrate that the detectors in a commercial QKD system Clavis2 can be blinded by heating the avalanche photo diodes (APDs) using bright illumination, so-called thermal blinding. Further, the detectors can be triggered using short bright pulses once they are blind. For systems with pauses between packet transmission such as the plug-and-play systems, thermal inertia enables Eve to apply the bright blinding illumination before eavesdropping, making her more difficult to catch.

  10. Thermal blinding of gated detectors in quantum cryptography.

    PubMed

    Lydersen, Lars; Wiechers, Carlos; Wittmann, Christoffer; Elser, Dominique; Skaar, Johannes; Makarov, Vadim

    2010-12-20

    It has previously been shown that the gated detectors of two commercially available quantum key distribution (QKD) systems are blindable and controllable by an eavesdropper using continuous-wave illumination and short bright trigger pulses, manipulating voltages in the circuit [Nat. Photonics 4, 686 (2010)]. This allows for an attack eavesdropping the full raw and secret key without increasing the quantum bit error rate (QBER). Here we show how thermal effects in detectors under bright illumination can lead to the same outcome. We demonstrate that the detectors in a commercial QKD system Clavis2 can be blinded by heating the avalanche photo diodes (APDs) using bright illumination, so-called thermal blinding. Further, the detectors can be triggered using short bright pulses once they are blind. For systems with pauses between packet transmission such as the plug-and-play systems, thermal inertia enables Eve to apply the bright blinding illumination before eavesdropping, making her more difficult to catch. PMID:21197067

  11. Effects of detector efficiency mismatch on security of quantum cryptosystems

    SciTech Connect

    Makarov, Vadim; Anisimov, Andrey; Skaar, Johannes

    2006-08-15

    We suggest a type of attack on quantum cryptosystems that exploits variations in detector efficiency as a function of a control parameter accessible to an eavesdropper. With gated single-photon detectors, this control parameter can be the timing of the incoming pulse. When the eavesdropper sends short pulses using the appropriate timing so that the two gated detectors in Bob's setup have different efficiencies, the security of quantum key distribution can be compromised. Specifically, we show for the Bennett-Brassard 1984 (BB84) protocol that if the efficiency mismatch between 0 and 1 detectors for some value of the control parameter gets large enough (roughly 15:1 or larger), Eve can construct a successful faked-states attack causing a quantum bit error rate lower than 11%. We also derive a general security bound as a function of the detector sensitivity mismatch for the BB84 protocol. Experimental data for two different detectors are presented, and protection measures against this attack are discussed.

  12. Quantum efficiency of a double quantum dot microwave photon detector

    NASA Astrophysics Data System (ADS)

    Wong, Clement; Vavilov, Maxim

    Motivated by recent interest in implementing circuit quantum electrodynamics with semiconducting quantum dots, we study charge transfer through a double quantum dot (DQD) capacitively coupled to a superconducting cavity subject to a microwave field. We analyze the DQD current response using input-output theory and determine the optimal parameter regime for complete absorption of radiation and efficient conversion of microwave photons to electric current. For experimentally available DQD systems, we show that the cavity-coupled DQD operates as a photon-to-charge converter with quantum efficiencies up to 80% C.W. acknowledges support by the Intelligence Community Postdoctoral Research Fellowship Program.

  13. Terahertz hot electron bolometric detectors based on graphene quantum dots

    NASA Astrophysics Data System (ADS)

    El Fatimy, A.; Myers-Ward, R. L.; Boyd, A. K.; Daniels, K. M.; Gaskill, D. K.; Barbara, P.

    2015-03-01

    We study graphene quantum dots patterned from epitaxial graphene on SiC with a resistance strongly dependent on temperature. The combination of weak electron-phonon coupling and small electronic heat capacity in graphene makes these quantum dots ideal hot-electron bolometers. We measure and characterize the THz optical response of devices with different dot sizes, at operating temperatures from 2.5K to 80K. The high responsivity, the potential for operation above 80 K and the process scalability show great promise towards practical applications of graphene quantum dot THz detectors. This work was sponsored by the U.S. Office of Naval Research (Award Number N000141310865).

  14. Quantum Measurement Theory in Gravitational-Wave Detectors

    NASA Astrophysics Data System (ADS)

    Danilishin, Stefan L.; Khalili, Farid Ya.

    2012-04-01

    The fast progress in improving the sensitivity of the gravitational-wave detectors, we all have witnessed in the recent years, has propelled the scientific community to the point at which quantum behavior of such immense measurement devices as kilometer-long interferometers starts to matter. The time when their sensitivity will be mainly limited by the quantum noise of light is around the corner, and finding ways to reduce it will become a necessity. Therefore, the primary goal we pursued in this review was to familiarize a broad spectrum of readers with the theory of quantum measurements in the very form it finds application in the area of gravitational-wave detection. We focus on how quantum noise arises in gravitational-wave interferometers and what limitations it imposes on the achievable sensitivity. We start from the very basic concepts and gradually advance to the general linear quantum measurement theory and its application to the calculation of quantum noise in the contemporary and planned interferometric detectors of gravitational radiation of the first and second generation. Special attention is paid to the concept of the Standard Quantum Limit and the methods of its surmounting.

  15. A Voltage-Tunable Quantum Well Detector for Terahertz Radiation

    NASA Astrophysics Data System (ADS)

    Briceño, G.; Williams, J. B.; Sherwin, M. S.; Campman, K.; Gossard, A. C.

    1997-03-01

    Intersubband transitions in quantum wells have enabled the development of sensitive quantum well infrared photoconductors (QWIP) at wavelengths shorter than 20 microns. The potential of quantum well-based detectors at wavelengths of order 100 microns (3 Terahertz (THz)) has not been realized. We propose a novel antenna-coupled intersubband detector for THz frequencies. The detector is predicted to be sensitive only in a narrow band of frequencies which can be tuned by a factor of order two by applying dc voltages of order 1V. The speed of the detector is predicted to be limited by the intersubband relaxation rate (1 ns at T=10K)(J. N. Heyman et. al., Phys. Rev. Lett. 74), 2682 (1995). Prototype detectors have been constructed. The structure, dc transport characteristics and response of these devices to THz radiation will be discussed. Supported by the NSF Science and Technology Center for Quantized Electronic Structures DMR 91-20007, NSF DMR 9623874, AFOSR F-49620-94-1-0158, and the Ford Foundation (GB).

  16. InAs/AlAsSb based quantum cascade detector

    SciTech Connect

    Reininger, Peter Zederbauer, Tobias; Schwarz, Benedikt; MacFarland, Donald; Andrews, Aaron Maxwell; Schrenk, Werner; Strasser, Gottfried; Detz, Hermann

    2015-08-24

    In this letter, we introduce the InAs/AlAsSb material system for quantum cascade detectors (QCDs). InAs/AlAsSb can be grown lattice matched to InAs and exhibits a conduction band offset of approximately 2.1 eV, enabling the design of very short wavelength quantum cascade detectors. Another benefit using this material system is the low effective mass of the well material that improves the total absorption of the detector and decreases the intersubband scattering rates, which increases the device resistance and thus enhances the noise behavior. We have designed, grown, and measured a QCD that detects at a wavelength of λ = 4.84 μm and shows a peak specific detectivity of approximately 2.7 × 10{sup 7 }Jones at T = 300 K.

  17. Resonant infrared detector with substantially unit quantum efficiency

    NASA Technical Reports Server (NTRS)

    Farhoomand, Jam (Inventor); Mcmurray, Robert E., Jr. (Inventor)

    1994-01-01

    A resonant infrared detector includes an infrared-active layer which has first and second parallel faces and which absorbs radiation of a given wavelength. The detector also includes a first tuned reflective layer, disposed opposite the first face of the infrared-active layer, which reflects a specific portion of the radiation incident thereon and allows a specific portion of the incident radiation at the given wavelength to reach the infrared-active layer. A second reflective layer, disposed opposite the second face of the infrared-active layer, reflects back into the infrared-active layer substantially all of the radiation at the given wavelength which passes through the infrared-active layer. The reflective layers have the effect of increasing the quantum efficiency of the infrared detector relative to the quantum efficiency of the infrared-active layer alone.

  18. Quantum key distribution without detector vulnerabilities using optically seeded lasers

    NASA Astrophysics Data System (ADS)

    Comandar, L. C.; Lucamarini, M.; Fröhlich, B.; Dynes, J. F.; Sharpe, A. W.; Tam, S. W.-B.; Yuan, Z. L.; Penty, R. V.; Shields, A. J.

    2016-05-01

    Security in quantum cryptography is continuously challenged by inventive attacks targeting the real components of a cryptographic set-up, and duly restored by new countermeasures to foil them. Owing to their high sensitivity and complex design, detectors are the most frequently attacked components. It was recently shown that two-photon interference from independent light sources can be used to remove any vulnerability from detectors. This new form of detection-safe quantum key distribution (QKD), termed measurement-device-independent (MDI), has been experimentally demonstrated but with modest key rates. Here, we introduce a new pulsed laser seeding technique to obtain high-visibility interference from gain-switched lasers and thereby perform MDI-QKD with unprecedented key rates in excess of 1 megabit per second in the finite-size regime. This represents a two to six orders of magnitude improvement over existing implementations and supports the new scheme as a practical resource for secure quantum communications.

  19. Interferometric Quantum-Nondemolition Single-Photon Detectors

    NASA Technical Reports Server (NTRS)

    Kok, Peter; Lee, Hwang; Dowling, Jonathan

    2007-01-01

    Two interferometric quantum-nondemolition (QND) devices have been proposed: (1) a polarization-independent device and (2) a polarization-preserving device. The prolarization-independent device works on an input state of up to two photons, whereas the polarization-preserving device works on a superposition of vacuum and single- photon states. The overall function of the device would be to probabilistically generate a unique detector output only when its input electromagnetic mode was populated by a single photon, in which case its output mode would also be populated by a single photon. Like other QND devices, the proposed devices are potentially useful for a variety of applications, including such areas of NASA interest as quantum computing, quantum communication, detection of gravity waves, as well as pedagogical demonstrations of the quantum nature of light. Many protocols in quantum computation and quantum communication require the possibility of detecting a photon without destroying it. The only prior single- photon-detecting QND device is based on quantum electrodynamics in a resonant cavity and, as such, it depends on the photon frequency. Moreover, the prior device can distinguish only between one photon and no photon. The proposed interferometric QND devices would not depend on frequency and could distinguish between (a) one photon and (b) zero or two photons. The first proposed device is depicted schematically in Figure 1. The input electromagnetic mode would be a superposition of a zero-, a one-, and a two-photon quantum state. The overall function of the device would be to probabilistically generate a unique detector output only when its input electromagnetic mode was populated by a single photon, in which case its output mode also would be populated by a single photon.

  20. Resonant metamaterial detectors based on THz quantum-cascade structures

    NASA Astrophysics Data System (ADS)

    Benz, A.; Krall, M.; Schwarz, S.; Dietze, D.; Detz, H.; Andrews, A. M.; Schrenk, W.; Strasser, G.; Unterrainer, K.

    2014-03-01

    We present the design, fabrication and characterisation of an intersubband detector employing a resonant metamaterial coupling structure. The semiconductor heterostructure relies on a conventional THz quantum-cascade laser design and is operated at zero bias for the detector operation. The same active region can be used to generate or detect light depending on the bias conditions and the vertical confinement. The metamaterial is processed directly into the top metal contact and is used to couple normal incidence radiation resonantly to the intersubband transitions. The device is capable of detecting light below and above the reststrahlenband of gallium-arsenide corresponding to the mid-infrared and THz spectral region.

  1. Resonant metamaterial detectors based on THz quantum-cascade structures

    PubMed Central

    Benz, A.; Krall, M.; Schwarz, S.; Dietze, D.; Detz, H.; Andrews, A. M.; Schrenk, W.; Strasser, G.; Unterrainer, K.

    2014-01-01

    We present the design, fabrication and characterisation of an intersubband detector employing a resonant metamaterial coupling structure. The semiconductor heterostructure relies on a conventional THz quantum-cascade laser design and is operated at zero bias for the detector operation. The same active region can be used to generate or detect light depending on the bias conditions and the vertical confinement. The metamaterial is processed directly into the top metal contact and is used to couple normal incidence radiation resonantly to the intersubband transitions. The device is capable of detecting light below and above the reststrahlenband of gallium-arsenide corresponding to the mid-infrared and THz spectral region. PMID:24608677

  2. Quantum detector tomography of a single-photon frequency upconversion detection system.

    PubMed

    Ma, Jianhui; Chen, Xiuliang; Hu, Huiqin; Pan, Haifeng; Wu, E; Zeng, Heping

    2016-09-01

    We experimentally presented a full quantum detector tomography of a synchronously pumped infrared single-photon frequency upconversion detector. A maximum detection efficiency of 37.6% was achieved at the telecom wavelength of 1558 nm with a background noise about 1.0 × 10-3 counts/pulse. The corresponding internal quantum conversion efficiency reached as high as 84.4%. The detector was then systematically characterized at different pump powers to investigate the quantum decoherence behavior. Here the reconstructed positive operator valued measure elements were equivalently illustrated with the Wigner function formalism, where the quantum feature of the detector is manifested by the presence of negative values of the Wigner function. In our experiment, pronounced negativities were attained due to the high detection efficiency and low background noise, explicitly showing the quantum feature of the detector. Such quantum detector could be useful in optical quantum state engineering, quantum information processing and communication. PMID:27607700

  3. Quantum detector tomography of a single-photon frequency upconversion detection system.

    PubMed

    Ma, Jianhui; Chen, Xiuliang; Hu, Huiqin; Pan, Haifeng; Wu, E; Zeng, Heping

    2016-09-01

    We experimentally presented a full quantum detector tomography of a synchronously pumped infrared single-photon frequency upconversion detector. A maximum detection efficiency of 37.6% was achieved at the telecom wavelength of 1558 nm with a background noise about 1.0 × 10-3 counts/pulse. The corresponding internal quantum conversion efficiency reached as high as 84.4%. The detector was then systematically characterized at different pump powers to investigate the quantum decoherence behavior. Here the reconstructed positive operator valued measure elements were equivalently illustrated with the Wigner function formalism, where the quantum feature of the detector is manifested by the presence of negative values of the Wigner function. In our experiment, pronounced negativities were attained due to the high detection efficiency and low background noise, explicitly showing the quantum feature of the detector. Such quantum detector could be useful in optical quantum state engineering, quantum information processing and communication.

  4. An improved far-infrared microscope with quantum Hall detectors

    NASA Astrophysics Data System (ADS)

    Ikushima, Kenji; Sakuma, Hisato; Komiyama, Susumu

    2003-05-01

    A highly-sensitive scanning far-infrared (FIR) microscope is developed. The microscope consists of a silicon solid immersion lens that probes FIR and a condenser lens that focuses the FIR onto a small and highly-sensitive quantum Hall detector. The solid immersion lens is in contact with a sample, which is moved with a mechanical stage. The microscope is successfully applied to image extremely weak cyclotron emission from quantum Hall devices with a spatial resolution about 50 μm and a signal-to-noise ratio improved by a factor 18 compared to a previous system.

  5. Detector-device-independent quantum key distribution

    SciTech Connect

    Lim, Charles Ci Wen; Korzh, Boris; Martin, Anthony; Bussières, Félix; Thew, Rob; Zbinden, Hugo

    2014-12-01

    Recently, a quantum key distribution (QKD) scheme based on entanglement swapping, called measurement-device-independent QKD (mdiQKD), was proposed to bypass all measurement side-channel attacks. While mdiQKD is conceptually elegant and offers a supreme level of security, the experimental complexity is challenging for practical systems. For instance, it requires interference between two widely separated independent single-photon sources, and the secret key rates are dependent on detecting two photons—one from each source. Here, we demonstrate a proof-of-principle experiment of a QKD scheme that removes the need for a two-photon system and instead uses the idea of a two-qubit single-photon to significantly simplify the implementation and improve the efficiency of mdiQKD in several aspects.

  6. Investigation of the quantum efficiency of optical heterodyne detectors

    NASA Technical Reports Server (NTRS)

    Batchman, T. E.

    1984-01-01

    The frequency response and quantum efficiency of optical photodetectors for heterodyne receivers is investigated. The measurements utilized two spectral lines from the output of two lasers as input to the photodetectors. These lines are easily measurable in power and frequency and hence serve as known inputs. By measuring the output current of the photodetector the quantum efficiency is determined as a function of frequency separation between the two input signals. An investigation of the theoretical basis and accuracy of this type of measurement relative to similar measurements utilizing risetime is undertaken. A theoretical study of the heterodyne process in photodetectors based on semiconductor physics is included so that higher bandwidth detectors may be designed. All measurements are made on commercially available detectors and manufacturers' specifications for normal photodetector operation are compared to the measured heterodyne characteristics.

  7. Quantum key distribution over 120 km using ultrahigh purity single-photon source and superconducting single-photon detectors

    PubMed Central

    Takemoto, Kazuya; Nambu, Yoshihiro; Miyazawa, Toshiyuki; Sakuma, Yoshiki; Yamamoto, Tsuyoshi; Yorozu, Shinichi; Arakawa, Yasuhiko

    2015-01-01

    Advances in single-photon sources (SPSs) and single-photon detectors (SPDs) promise unique applications in the field of quantum information technology. In this paper, we report long-distance quantum key distribution (QKD) by using state-of-the-art devices: a quantum-dot SPS (QD SPS) emitting a photon in the telecom band of 1.5 μm and a superconducting nanowire SPD (SNSPD). At the distance of 100 km, we obtained the maximal secure key rate of 27.6 bps without using decoy states, which is at least threefold larger than the rate obtained in the previously reported 50-km-long QKD experiment. We also succeeded in transmitting secure keys at the rate of 0.307 bps over 120 km. This is the longest QKD distance yet reported by using known true SPSs. The ultralow multiphoton emissions of our SPS and ultralow dark count of the SNSPD contributed to this result. The experimental results demonstrate the potential applicability of QD SPSs to practical telecom QKD networks. PMID:26404010

  8. Quantum key distribution over 120 km using ultrahigh purity single-photon source and superconducting single-photon detectors

    NASA Astrophysics Data System (ADS)

    Takemoto, Kazuya; Nambu, Yoshihiro; Miyazawa, Toshiyuki; Sakuma, Yoshiki; Yamamoto, Tsuyoshi; Yorozu, Shinichi; Arakawa, Yasuhiko

    2015-09-01

    Advances in single-photon sources (SPSs) and single-photon detectors (SPDs) promise unique applications in the field of quantum information technology. In this paper, we report long-distance quantum key distribution (QKD) by using state-of-the-art devices: a quantum-dot SPS (QD SPS) emitting a photon in the telecom band of 1.5 μm and a superconducting nanowire SPD (SNSPD). At the distance of 100 km, we obtained the maximal secure key rate of 27.6 bps without using decoy states, which is at least threefold larger than the rate obtained in the previously reported 50-km-long QKD experiment. We also succeeded in transmitting secure keys at the rate of 0.307 bps over 120 km. This is the longest QKD distance yet reported by using known true SPSs. The ultralow multiphoton emissions of our SPS and ultralow dark count of the SNSPD contributed to this result. The experimental results demonstrate the potential applicability of QD SPSs to practical telecom QKD networks.

  9. Porous Silicon-Based Quantum Dot Broad Spectrum Radiation Detector.

    PubMed

    Urdaneta, M; Stepanov, P; Weinberg, I N; Pala, I R; Brock, S

    2011-01-11

    Silicon is a convenient and inexpensive platform for radiation detection, but has low stopping power for x-rays and gamma-rays with high energy (e.g., 100 keV, as used in computed tomography and digital radiography, or 1 MeV, as desired for detection of nuclear materials). We have effectively increased the stopping power of silicon detectors by producing a layer of porous or micro-machined silicon, and infusing this layer with semiconductor quantum dots made of electron-dense materials. Results of prototype detectors show sensitivity to infrared, visible light, and x-rays, with dark current of less than 1 nA/mm(2). PMID:24432047

  10. Limitation of decoy-state Scarani-Acin-Ribordy-Gisin quantum-key-distribution protocols with a heralded single-photon source

    SciTech Connect

    Zhang Shengli; Zou Xubo; Li Ke; Guo Guangcan; Jin Chenhui

    2007-10-15

    For the Bennett-Brassard 1984 (BB84) quantum key distribution, longer distance and higher key generating rate is shown with a heralded single-photon source (HSPS) [Phys. Rev. A. 73, 032331 (2006)]. In this paper, the performance of the Scarani-Acin-Ribordy-Gisim (SARG) protocol utilizing the HSPS sources is considered and the numerical simulation turns out that still a significant improvement in secret key generating rate can also be observed. It is shown that the security distance for HSPS+SARG is 120 km. However, compared with the HSPS+BB84 protocols, the HSPS+SARG protocol has a lower secret key rate and a shorter distance. Thus we show the HSPS+BB84 implementation is a preferable protocol for long distance transmittance.

  11. Optimised quantum hacking of superconducting nanowire single-photon detectors.

    PubMed

    Tanner, Michael G; Makarov, Vadim; Hadfield, Robert H

    2014-03-24

    We explore bright-light control of superconducting nanowire single-photon detectors (SNSPDs) in the shunted configuration (a practical measure to avoid latching). In an experiment, we simulate an illumination pattern the SNSPD would receive in a typical quantum key distribution system under hacking attack. We show that it effectively blinds and controls the SNSPD. The transient blinding illumination lasts for a fraction of a microsecond and produces several deterministic fake clicks during this time. This attack does not lead to elevated timing jitter in the spoofed output pulse, and hence does not introduce significant errors. Five different SNSPD chip designs were tested. We consider possible countermeasures to this attack. PMID:24664022

  12. Optimised quantum hacking of superconducting nanowire single-photon detectors.

    PubMed

    Tanner, Michael G; Makarov, Vadim; Hadfield, Robert H

    2014-03-24

    We explore bright-light control of superconducting nanowire single-photon detectors (SNSPDs) in the shunted configuration (a practical measure to avoid latching). In an experiment, we simulate an illumination pattern the SNSPD would receive in a typical quantum key distribution system under hacking attack. We show that it effectively blinds and controls the SNSPD. The transient blinding illumination lasts for a fraction of a microsecond and produces several deterministic fake clicks during this time. This attack does not lead to elevated timing jitter in the spoofed output pulse, and hence does not introduce significant errors. Five different SNSPD chip designs were tested. We consider possible countermeasures to this attack.

  13. Optimised quantum hacking of superconducting nanowire single-photon detectors

    NASA Astrophysics Data System (ADS)

    Tanner, Michael G.; Makarov, Vadim; Hadfield, Robert H.

    2014-03-01

    We explore bright-light control of superconducting nanowire single-photon detectors (SNSPDs) in the shunted configuration (a practical measure to avoid latching). In an experiment, we simulate an illumination pattern the SNSPD would receive in a typical quantum key distribution system under hacking attack. We show that it effectively blinds and controls the SNSPD. The transient blinding illumination lasts for a fraction of a microsecond and produces several deterministic fake clicks during this time. This attack does not lead to elevated timing jitter in the spoofed output pulse, and hence does not introduce significant errors. Five different SNSPD chip designs were tested. We consider possible countermeasures to this attack.

  14. Enhanced observability of quantum postexponential decay using distant detectors

    SciTech Connect

    Torrontegui, E.; Muga, J. G.; Martorell, J.; Sprung, D. W. L.

    2009-07-15

    We study the elusive transition from exponential to postexponential (algebraic) decay of the probability density of a quantum particle emitted by an exponentially decaying source in one dimension. The main finding is that the probability density at the transition time, and thus its observability, increases with the distance of the detector from the source up to a critical distance beyond which exponential decay is no longer observed. Solvable models provide explicit expressions for the dependence of the transition on resonance and observational parameters, facilitating the choice of optimal conditions.

  15. Quantum detector tomography of a time-multiplexed superconducting nanowire single-photon detector at telecom wavelengths.

    PubMed

    Natarajan, Chandra M; Zhang, Lijian; Coldenstrodt-Ronge, Hendrik; Donati, Gaia; Dorenbos, Sander N; Zwiller, Val; Walmsley, Ian A; Hadfield, Robert H

    2013-01-14

    Superconducting nanowire single-photon detectors (SNSPDs) are widely used in telecom wavelength optical quantum information science applications. Quantum detector tomography allows the positive-operator-valued measure (POVM) of a single-photon detector to be determined. We use an all-fiber telecom wavelength detector tomography test bed to measure detector characteristics with respect to photon flux and polarization, and hence determine the POVM. We study the SNSPD both as a binary detector and in an 8-bin, fiber based, Time-Multiplexed (TM) configuration at repetition rates up to 4 MHz. The corresponding POVMs provide an accurate picture of the photon number resolving capability of the TM-SNSPD. PMID:23388983

  16. III-V semiconductor quantum well and superlattice detectors

    NASA Astrophysics Data System (ADS)

    Walther, Martin; Fuchs, Frank; Schneider, Harald; Fleissner, Joachim; Schmitz, J.; Pletschen, Wilfried; Braunstein, Juergen; Ziegler, Johann; Cabanski, Wolfgang A.; Koidl, Peter; Weimann, Guenter

    1998-10-01

    The paper reviews the development of IR detectors for the 8 - 12 micrometer wavelength range based on GaAs/AlGaAs quantum well structures and InAs/(GaIn)Sb short-period superlattices (SPSLs) at the Fraunhofer-Institute IAF. Photoconductive GaAs/AlGaAs quantum well infrared photodetectors (QWIPs) are used for the fabrication of starring IR cameras for thermal imaging in the third atmospheric window. The long wavelength infrared (LWIR) camera, devleoped in cooperation with AEG Infrarot-Module (AIM), consists of a two-dimensional focal plane array (FPA) with 256 X 256 detector elements, flip- chip bonded to a read-out integrated circuit (ROIC). The technology for the fabrication of FPAs, electrical and optical properties of single detector elements in the two-dimensional arrangement and the properties of the LWIR camera system are reported. A noise equivalent temperature difference (NETD) below 10 mK has been measured at an operation temperature of T equals 65 K with an integration time of 20 ms. More than 99.8% of all pixels are working and no cluster defects are observed. InAs/(GaIn)Sb SPSLs with a broken gap type-II band alignment are well suited for the fabrication of IR detectors covering the 3 - 12 micrometer spectral range. Due to the lattice mismatch of the InAs/(GaIn)Sb SPSL with respect to GaSb, tight control of thickness and composition of the layers and a controlled formation of the chemical bonds across the interface in the SPSLs are used for strain compensation. Photodiodes with a cut-off wavelength (lambda) c equals 8 micrometer and a current responsivity R(lambda ) equals 2 A/W exhibit a dynamic impedance of R0A equals 1k(Omega) cm2 at T equals 77 K. This leads to a Johnson- noise limited detectivity in excess of D* equals 1 X 1012 cm(Hz)1/2/W for these type of detectors.

  17. Balanced homodyne readout for quantum limited gravitational wave detectors.

    PubMed

    Fritschel, Peter; Evans, Matthew; Frolov, Valery

    2014-02-24

    Balanced homodyne detection is typically used to measure quantum-noise-limited optical beams, including squeezed states of light, at audio-band frequencies. Current designs of advanced gravitational wave interferometers use some type of homodyne readout for signal detection, in part because of its compatibility with the use of squeezed light. The readout scheme used in Advanced LIGO, called DC readout, is however not a balanced detection scheme. Instead, the local oscillator field, generated from a dark fringe offset, co-propagates with the signal field at the anti-symmetric output of the beam splitter. This article examines the alternative of a true balanced homodyne detection for the readout of gravitational wave detectors such as Advanced LIGO. Several practical advantages of the balanced detection scheme are described. PMID:24663746

  18. Chlorine doped graphene quantum dots: Preparation, properties, and photovoltaic detectors

    SciTech Connect

    Zhao, Jianhong; Xiang, Jinzhong; Tang, Libin Ji, Rongbin Yuan, Jun; Zhao, Jun; Yu, Ruiyun; Tai, Yunjian; Song, Liyuan

    2014-09-15

    Graphene quantum dots (GQDs) are becoming one of the hottest advanced functional materials because of the opening of the bandgap due to quantum confinement effect, which shows unique optical and electrical properties. The chlorine doped GQDs (Cl-GQDs) have been fabricated by chemical exfoliation of HCl treated carbon fibers (CFs), which were prepared from degreasing cotton through an annealing process at 1000 °C for 30 min. Raman study shows that both G and 2D peaks of GQDs may be redshifted (softened) by chlorine doping, leading to an n-type doping. The first vertical (Cl)-GQDs based photovoltaic detectors have been demonstrated, both the light absorbing and electron-accepting roles for (Cl)-GQDs in photodetection have been found, resulting in an exceptionally big ratio of photocurrent to dark current as high as ∼10{sup 5} at room temperature using a 405 nm laser irradiation under the reverse bias voltage. The study expands the application of (Cl)-GQDs to the important optoelectronic detection devices.

  19. Chlorine doped graphene quantum dots: Preparation, properties, and photovoltaic detectors

    NASA Astrophysics Data System (ADS)

    Zhao, Jianhong; Tang, Libin; Xiang, Jinzhong; Ji, Rongbin; Yuan, Jun; Zhao, Jun; Yu, Ruiyun; Tai, Yunjian; Song, Liyuan

    2014-09-01

    Graphene quantum dots (GQDs) are becoming one of the hottest advanced functional materials because of the opening of the bandgap due to quantum confinement effect, which shows unique optical and electrical properties. The chlorine doped GQDs (Cl-GQDs) have been fabricated by chemical exfoliation of HCl treated carbon fibers (CFs), which were prepared from degreasing cotton through an annealing process at 1000 °C for 30 min. Raman study shows that both G and 2D peaks of GQDs may be redshifted (softened) by chlorine doping, leading to an n-type doping. The first vertical (Cl)-GQDs based photovoltaic detectors have been demonstrated, both the light absorbing and electron-accepting roles for (Cl)-GQDs in photodetection have been found, resulting in an exceptionally big ratio of photocurrent to dark current as high as ˜105 at room temperature using a 405 nm laser irradiation under the reverse bias voltage. The study expands the application of (Cl)-GQDs to the important optoelectronic detection devices.

  20. Complementary barrier infrared detector (CBIRD) with double tunnel junction contact and quantum dot barrier infrared detector (QD-BIRD)

    NASA Astrophysics Data System (ADS)

    Ting, David Z.-Y.; Soibel, Alexander; Khoshakhlagh, Arezou; Keo, Sam A.; Nguyen, Jean; Höglund, Linda; Mumolo, Jason M.; Liu, John K.; Rafol, B., , Sir; Hill, Cory J.; Gunapala, Sarath D.

    2013-07-01

    The InAs/GaSb type-II superlattice based complementary barrier infrared detector (CBIRD) has already demonstrated very good performance in long-wavelength infrared (LWIR) detection. In this work, we describe results on a modified CBIRD device that incorporates a double tunnel junction contact designed for robust device and focal plane array processing. The new device also exhibited reduced turn-on voltage. We also report results on the quantum dot barrier infrared detector (QD-BIRD). By incorporating self-assembled InSb quantum dots into the InAsSb absorber of the standard nBn detector structure, the QD-BIRD extend the detector cutoff wavelength from ˜4.2 μm to 6 μm, allowing the coverage of the mid-wavelength infrared (MWIR) transmission window. The device has been observed to show infrared response at 225 K.

  1. Complementary Barrier Infrared Detector (CBIRD) with Double Tunnel Junction Contact and Quantum Dot Barrier Infrared Detector (QD-BIRD)

    NASA Technical Reports Server (NTRS)

    Ting, David Z.-Y; Soibel, Alexander; Khoshakhlagh, Arezou; Keo, Sam A.; Nguyen, Jean; Hoglund, Linda; Mumolo, Jason M.; Liu, John K.; Rafol, Sir B.; Hill, Cory J.; Gunapala, Sarath D.

    2012-01-01

    The InAs/GaSb type-II superlattice based complementary barrier infrared detector (CBIRD) has already demonstrated very good performance in long-wavelength infrared (LWIR) detection. In this work, we describe results on a modified CBIRD device that incorporates a double tunnel junction contact designed for robust device and focal plane array processing. The new device also exhibited reduced turn-on voltage. We also report results on the quantum dot barrier infrared detector (QD-BIRD). By incorporating self-assembled InSb quantum dots into the InAsSb absorber of the standard nBn detector structure, the QD-BIRD extend the detector cutoff wavelength from approximately 4.2 micrometers to 6 micrometers, allowing the coverage of the mid-wavelength infrared (MWIR) transmission window. The device has been observed to show infrared response at 225 K.

  2. Baiting Inside Attackers Using Decoy Documents

    NASA Astrophysics Data System (ADS)

    Bowen, Brian M.; Hershkop, Shlomo; Keromytis, Angelos D.; Stolfo, Salvatore J.

    The insider threat remains one of the most vexing problems in computer security. A number of approaches have been proposed to detect nefarious insider actions including user modeling and profiling techniques, policy and access enforcement techniques, and misuse detection. In this work we propose trap-based defense mechanisms and a deployment platform for addressing the problem of insiders attempting to exfiltrate and use sensitive information. The goal is to confuse and confound an adversary requiring more effort to identify real information from bogus information and provide a means of detecting when an attempt to exploit sensitive information has occurred. “Decoy Documents” are automatically generated and stored on a file system by the D3 System with the aim of enticing a malicious user. We introduce and formalize a number of properties of decoys as a guide to design trap-based defenses to increase the likelihood of detecting an insider attack. The decoy documents contain several different types of bogus credentials that when used, trigger an alert. We also embed “stealthy beacons” inside the documents that cause a signal to be emitted to a server indicating when and where the particular decoy was opened. We evaluate decoy documents on honeypots penetrated by attackers demonstrating the feasibility of the method.

  3. Paired carriers as a way to reduce quantum noise of multicarrier gravitational-wave detectors

    NASA Astrophysics Data System (ADS)

    Korobko, Mikhail; Voronchev, Nikita; Miao, Haixing; Khalili, Farid Ya.

    2015-02-01

    We explore new regimes of laser interferometric gravitational-wave detectors with multiple optical carriers which allow us to reduce the quantum noise of these detectors. In particular, we show that using two carriers with the opposite detunings, homodyne angles, and squeezing angles, but identical other parameters (the antisymmetric carriers), one can suppress the quantum noise in such a way that its spectrum follows the Standard Quantum Limit (SQL) at low frequencies. Relaxing this antisymmetry condition, it is also possible to slightly overcome the SQL in broadband. Combining several such pairs in the xylophone configuration, it is possible to shape the quantum noise spectrum flexibly.

  4. Development of novel decoy oligonucleotides: advantages of circular dumb-bell decoy.

    PubMed

    Tomita, Naruya; Tomita, Tetsuya; Yuyama, Kazuhiko; Tougan, Takahiro; Tajima, Tsuyoshi; Ogihara, Toshio; Morishita, Ryuichi

    2003-04-01

    The inhibition of specific transcription regulatory proteins is a novel approach to regulate gene expression. The transcriptional activities of DNA binding proteins can be inhibited by the use of double-stranded oligonucleotides (ODNs) that compete for binding to their specific target sequences in promoters and enhancers. Transfection of this cis-element double-stranded ODN, referred to as decoy ODN, has been reported to be a powerful tool that provides a new class of anti-gene strategies to gene therapy and permits examination of specific gene regulation. We have demonstrated the usefulness of this decoy ODN strategy in animal models of restenosis, myocardial infarction, glomerulonephritis and rheumatoid arthritis. However, one of the major limitations of decoy ODN technology is the rapid degradation of phosphodiester ODNs by intracellular nucleases. To date, several different types of double-stranded decoy ODNs have been developed to overcome this issue. Circular dumb-bell (CD) double-stranded decoy ODNs that were developed to resolve this issue have attracted a high level of interest. In this review, the applications of decoy ODN strategy and the advantages of modified CD double-stranded decoy ODNs will be discussed. PMID:12772498

  5. Development of novel decoy oligonucleotides: advantages of circular dumb-bell decoy.

    PubMed

    Tomita, Naruya; Tomita, Tetsuya; Yuyama, Kazuhiko; Tougan, Takahiro; Tajima, Tsuyoshi; Ogihara, Toshio; Morishita, Ryuichi

    2003-04-01

    The inhibition of specific transcription regulatory proteins is a novel approach to regulate gene expression. The transcriptional activities of DNA binding proteins can be inhibited by the use of double-stranded oligonucleotides (ODNs) that compete for binding to their specific target sequences in promoters and enhancers. Transfection of this cis-element double-stranded ODN, referred to as decoy ODN, has been reported to be a powerful tool that provides a new class of anti-gene strategies to gene therapy and permits examination of specific gene regulation. We have demonstrated the usefulness of this decoy ODN strategy in animal models of restenosis, myocardial infarction, glomerulonephritis and rheumatoid arthritis. However, one of the major limitations of decoy ODN technology is the rapid degradation of phosphodiester ODNs by intracellular nucleases. To date, several different types of double-stranded decoy ODNs have been developed to overcome this issue. Circular dumb-bell (CD) double-stranded decoy ODNs that were developed to resolve this issue have attracted a high level of interest. In this review, the applications of decoy ODN strategy and the advantages of modified CD double-stranded decoy ODNs will be discussed.

  6. Fiber coupled single photon receivers based on superconducting detectors for quantum communications and quantum cryptography

    NASA Astrophysics Data System (ADS)

    Smirnov, K. V.; Vachtomin, Yu. B.; Ozhegov, R. V.; Pentin, I. V.; Slivinskaya, E. V.; Korneev, A. A.; Goltsman, G. N.

    2008-11-01

    At present superconducting detectors become increasingly attractive for various practical applications. In this paper we present results on the depelopment of fiber coupled receiver systems for the registration of IR single photons, optimized for telecommunication and quantum-cryptography. These receiver systems were developed on the basis of superconducting single photon detectors (SSPD) of VIS and IR wavelength ranges. The core of the SSPD is a narrow (~100 nm) and long (~0,5 mm) strip in the form of a meander which is patterned from a 4-nm-thick NbN film (TC=10-11 K, jC=~5-7•106 A/cm2); the sensitive area dimensions are 10×10 μm2. The main problem to be solved while the receiver system development was optical coupling of a single-mode fiber (9 microns in diameter) with the SSPD sensitive area. Characteristics of the developed system at the optical input are as follows: quantum efficiency >10 % (at 1.3 μm), >4 % (at 1.55 μm) dark counts rate <=1 s-1; duration of voltage pulse <=5 ns; jitter <=40 ps. The receiver systems have either one or two identical channels (for the case of carrying out correlation measurements) and are made as an insert in a helium storage Dewar.

  7. A bifunctional spin detector made of quantum anomalous Hall insulator

    NASA Astrophysics Data System (ADS)

    Shi, Zhangsheng; Wu, Jiansheng

    2016-10-01

    The spin selection of the topological boundary states (TBS) which are protected by the chiral-like symmetry in quantum anomalous Hall insulator (QAHI) can be used to construct a bifunctional spin detector (SD). Such device made of QAHIs in parallel with opposite chirality can divide an incoming spin-polarized current into two outgoing currents. The agreement between numerical and analytical calculation proves that the SD device functions as both spin filter and spin separator well in reflecting the spin polarization of source material from the ratio of two currents. The monotonic relation of spin polarization and current ratio suggests that using such kind of device, the spin polarization can be obtained directly. We also find that such device has a broad working energy region attributed by the TBS within the bulk gap. Combining with the result that the current ratio is barely dependent on the coupling between candidate materials and device, it is reasonable to apply this technique with a stable measuring accuracy. Furthermore, the features such as having simple geometry, being manipulated without external magnetic field, and the prospect of working at room temperature make this proposed device seem promising in developing future low-power-consumption spintronic device.

  8. DecoyPyrat: Fast Non-redundant Hybrid Decoy Sequence Generation for Large Scale Proteomics

    PubMed Central

    Wright, James C; Choudhary, Jyoti S

    2016-01-01

    Accurate statistical evaluation of sequence database peptide identifications from tandem mass spectra is essential in mass spectrometry based proteomics experiments. These statistics are dependent on accurately modelling random identifications. The target-decoy approach has risen to become the de facto approach to calculating FDR in proteomic datasets. The main principle of this approach is to search a set of decoy protein sequences that emulate the size and composition of the target protein sequences searched whilst not matching real proteins in the sample. To do this, it is commonplace to reverse or shuffle the proteins and peptides in the target database. However, these approaches have their drawbacks and limitations. A key confounding issue is the peptide redundancy between target and decoy databases leading to inaccurate FDR estimation. This inaccuracy is further amplified at the protein level and when searching large sequence databases such as those used for proteogenomics. Here, we present a unifying hybrid method to quickly and efficiently generate decoy sequences with minimal overlap between target and decoy peptides. We show that applying a reversed decoy approach can produce up to 5% peptide redundancy and many more additional peptides will have the exact same precursor mass as a target peptide. Our hybrid method addresses both these issues by first switching proteolytic cleavage sites with preceding amino acid, reversing the database and then shuffling any redundant sequences. This flexible hybrid method reduces the peptide overlap between target and decoy peptides to about 1% of peptides, making a more robust decoy model suitable for large search spaces. We also demonstrate the anti-conservative effect of redundant peptides on the calculation of q-values in mouse brain tissue data. PMID:27418748

  9. Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking

    PubMed Central

    2012-01-01

    A key metric to assess molecular docking remains ligand enrichment against challenging decoys. Whereas the directory of useful decoys (DUD) has been widely used, clear areas for optimization have emerged. Here we describe an improved benchmarking set that includes more diverse targets such as GPCRs and ion channels, totaling 102 proteins with 22886 clustered ligands drawn from ChEMBL, each with 50 property-matched decoys drawn from ZINC. To ensure chemotype diversity, we cluster each target’s ligands by their Bemis–Murcko atomic frameworks. We add net charge to the matched physicochemical properties and include only the most dissimilar decoys, by topology, from the ligands. An online automated tool (http://decoys.docking.org) generates these improved matched decoys for user-supplied ligands. We test this data set by docking all 102 targets, using the results to improve the balance between ligand desolvation and electrostatics in DOCK 3.6. The complete DUD-E benchmarking set is freely available at http://dude.docking.org. PMID:22716043

  10. A highly sensitive scanning far-infrared microscope with quantum Hall detectors

    NASA Astrophysics Data System (ADS)

    Ikushima, Kenji; Sakuma, Hisato; Komiyama, Susumu

    2003-09-01

    We develop a highly sensitive scanning far-infrared (FIR) microscope, which consists of a silicon solid immersion lens that probes FIR and a condenser lens that focuses the FIR onto a small quantum Hall detector (400 μm×400 μm). The solid immersion lens is in contact with the backside of a Hall bar sample, which is moved with a mechanical XY stage. The quantum Hall detector, which function as a narrow band FIR detector (bandwidth of about 2%), is a Hall bar with a large length-to-width ratio in integer quantum Hall effect regimes. The microscope is successfully applied to image extremely weak cyclotron emissions from quantum Hall devices with a spatial resolution of about 50 μm and a signal-to-noise ratio improved by a factor 18 compared to a previous system.

  11. Finite-key security analyses on passive decoy-state QKD protocols with different unstable sources.

    PubMed

    Song, Ting-Ting; Qin, Su-Juan; Wen, Qiao-Yan; Wang, Yu-Kun; Jia, Heng-Yue

    2015-01-01

    In quantum communication, passive decoy-state QKD protocols can eliminate many side channels, but the protocols without any finite-key analyses are not suitable for in practice. The finite-key securities of passive decoy-state (PDS) QKD protocols with two different unstable sources, type-II parametric down-convention (PDC) and phase randomized weak coherent pulses (WCPs), are analyzed in our paper. According to the PDS QKD protocols, we establish an optimizing programming respectively and obtain the lower bounds of finite-key rates. Under some reasonable values of quantum setup parameters, the lower bounds of finite-key rates are simulated. The simulation results show that at different transmission distances, the affections of different fluctuations on key rates are different. Moreover, the PDS QKD protocol with an unstable PDC source can resist more intensity fluctuations and more statistical fluctuation. PMID:26471947

  12. Finite-key security analyses on passive decoy-state QKD protocols with different unstable sources

    PubMed Central

    Song, Ting-Ting; Qin, Su-Juan; Wen, Qiao-Yan; Wang, Yu-Kun; Jia, Heng-Yue

    2015-01-01

    In quantum communication, passive decoy-state QKD protocols can eliminate many side channels, but the protocols without any finite-key analyses are not suitable for in practice. The finite-key securities of passive decoy-state (PDS) QKD protocols with two different unstable sources, type-II parametric down-convention (PDC) and phase randomized weak coherent pulses (WCPs), are analyzed in our paper. According to the PDS QKD protocols, we establish an optimizing programming respectively and obtain the lower bounds of finite-key rates. Under some reasonable values of quantum setup parameters, the lower bounds of finite-key rates are simulated. The simulation results show that at different transmission distances, the affections of different fluctuations on key rates are different. Moreover, the PDS QKD protocol with an unstable PDC source can resist more intensity fluctuations and more statistical fluctuation. PMID:26471947

  13. Finite-key security analyses on passive decoy-state QKD protocols with different unstable sources.

    PubMed

    Song, Ting-Ting; Qin, Su-Juan; Wen, Qiao-Yan; Wang, Yu-Kun; Jia, Heng-Yue

    2015-10-16

    In quantum communication, passive decoy-state QKD protocols can eliminate many side channels, but the protocols without any finite-key analyses are not suitable for in practice. The finite-key securities of passive decoy-state (PDS) QKD protocols with two different unstable sources, type-II parametric down-convention (PDC) and phase randomized weak coherent pulses (WCPs), are analyzed in our paper. According to the PDS QKD protocols, we establish an optimizing programming respectively and obtain the lower bounds of finite-key rates. Under some reasonable values of quantum setup parameters, the lower bounds of finite-key rates are simulated. The simulation results show that at different transmission distances, the affections of different fluctuations on key rates are different. Moreover, the PDS QKD protocol with an unstable PDC source can resist more intensity fluctuations and more statistical fluctuation.

  14. Calibration of single-photon detectors using quantum statistics

    SciTech Connect

    Mogilevtsev, D.

    2010-08-15

    I show that calibration of the single-photon detector can be performed without knowledge of the signal parameters. Only partial information about the state statistics is sufficient for that. If one knows that the state is the squeezed one or the squeezed one mixed with the incoherent radiation, one can infer both the parameters of the state and the efficiency of the detector. For that one needs only to measure on/off statistics of detector clicks for the number of known absorbers placed before the detector. Thus, I suggest a scheme that performs a tomography of the signal and the measuring apparatus simultaneously.

  15. A Novel Particle Detector: Quantum Dot Doped Liquid Scintillator

    NASA Astrophysics Data System (ADS)

    Winslow, Lindley; Conrad, Janet; Jerry, Ruel

    2010-02-01

    Quantum dots are semiconducting nanocrystals. When excited by light shorter then their characteristic wavelength, they re-emit in a narrow band around this wavelength. The size of the quantum is proportional to the characteristic wavelength so they can be tuned for many applications. CdS quantum dots are made in wavelengths from 360nm to 460nm, a perfect range for the sensitivity of photo-multiplier tubes. The synthesis of quantum dots automatically leaves them in toluene, a good organic scintillator and Cd is a particularly interesting material as it has one of the highest thermal neutron cross sections and has several neutrinoless double beta decay and double electron capture isotopes. The performance of quantum dot loaded scintillator compared to standard scintillators is measured and some unique properties presented. )

  16. Quantum efficiency test set up performances for NIR detector characterization at ESTEC

    NASA Astrophysics Data System (ADS)

    Crouzet, P.-E.; Duvet, L.; De Wit, F.; Beaufort, T.; Blommaert, S.; Butler, B.; Van Duinkerken, G.; ter Haar, J.; Heijnen, J.; van der Luijt, K.; Smit, H.; Viale, T.

    2014-07-01

    The Payload Technology Validation Section (Future mission preparation Office) at ESTEC is in charge of specific mission oriented validation activities, for science and robotic exploration missions, aiming at reducing development risks in the implementation phase. These activities take place during the early mission phases or during the implementation itself. In this framework, a test set up to characterize the quantum efficiency of near infrared detectors has been developed. The first detector to be tested will an HAWAII-2RG detector with a 2.5μm cut off, it will be used as commissioning device in preparation to the tests of prototypes European detectors developed under ESA funding. The capability to compare on the same setup detectors from different manufacturers will be a unique asset for the future mission preparation office. This publication presents the performances of the quantum efficiency test bench to prepare measurements on the HAWAII-2RG detector. A SOFRADIR Saturn detector has been used as a preliminary test vehicle for the bench. A test set up with a lamp, chopper, monochromator, pinhole and off axis mirrors allows to create a spot of 1mm diameter between 700nm and 2.5μm.The shape of the beam has been measured to match the rms voltage read by the Merlin Lock -in amplifier and the amplitude of the incoming signal. The reference detectors have been inter-calibrated with an uncertainty up to 3 %. For the measurement with HAWAII-2RG detector, the existing cryostat [1] has been modified to adapt cold black baffling, a cold filter wheel and a sapphire window. An statistic uncertainty of +/-2.6% on the quantum efficiency on the detector under test measurement is expected.

  17. Beyond Advanced Gravitational Wave Detectors: Beating the Quantum Limit with Squeezed States of Light

    NASA Astrophysics Data System (ADS)

    Barsotti, Lisa

    2013-04-01

    After two decades of technology development, the first direct observation of gravitational waves appears to be imminent. Ground-based interferometric gravitational wave detectors world-wide are about to come back on-line after a major upgrade aimed to significantly improve their sensitivity. As these advanced detectors become a reality, the gravitational wave community is looking at new ways of further expanding their astrophysical reach. The quantum nature of light imposes a fundamental limit to the sensitivity that gravitational wave detectors can achieve, due to statistical fluctuations in the arrival time of photons at the interferometer output (shot noise) and the recoil of the mirrors due to radiation pressure noise. In this talk I will show how mature technology can be used to push interferometric precision measurement beyond the standard quantum limit by means of squeezed states of light, and current ideas on how to integrate this technology into the Advanced detectors of the Laser Interferometer Gravitational wave Observatory (LIGO).

  18. Magnetotransport in very long wave infrared quantum cascade detectors: Analyzing the current with and without illumination

    SciTech Connect

    Jasnot, François-Régis; Maëro, Simon; Vaulchier, Louis-Anne de; Guldner, Yves; Carosella, Francesca; Ferreira, Robson; Delga, Alexandre; Doyennette, Laetitia; Berger, Vincent; Carras, Mathieu

    2013-12-04

    Current measurements of current have been performed on a very long wave infrared quantum cascade detector under magnetic field under both dark and light conditions. The analysis of dark current as a function of temperature highlights three regimes of transport. Under illumination, the model developed is in agreement with the oscillatory component of the experimental magnetophotocurrent. It allows to identify the key points controlling the electronic transport: crucial role of extraction, location of ionized impurities and scattering mechanisms involved in the structure. This work is valuable for the future conception of high-performance quantum cascade detectors in the infrared range.

  19. Performance of SEM scintillation detector evaluated by modulation transfer function and detective quantum efficiency function.

    PubMed

    Bok, Jan; Schauer, Petr

    2014-01-01

    In the paper, the SEM detector is evaluated by the modulation transfer function (MTF) which expresses the detector's influence on the SEM image contrast. This is a novel approach, since the MTF was used previously to describe only the area imaging detectors, or whole imaging systems. The measurement technique and calculation of the MTF for the SEM detector are presented. In addition, the measurement and calculation of the detective quantum efficiency (DQE) as a function of the spatial frequency for the SEM detector are described. In this technique, the time modulated e-beam is used in order to create well-defined input signal for the detector. The MTF and DQE measurements are demonstrated on the Everhart-Thornley scintillation detector. This detector was alternated using the YAG:Ce, YAP:Ce, and CRY18 single-crystal scintillators. The presented MTF and DQE characteristics show good imaging properties of the detectors with the YAP:Ce or CRY18 scintillator, especially for a specific type of the e-beam scan. The results demonstrate the great benefit of the description of SEM detectors using the MTF and DQE. In addition, point-by-point and continual-sweep e-beam scans in SEM were discussed and their influence on the image quality was revealed using the MTF. PMID:24323770

  20. Performance of SEM scintillation detector evaluated by modulation transfer function and detective quantum efficiency function.

    PubMed

    Bok, Jan; Schauer, Petr

    2014-01-01

    In the paper, the SEM detector is evaluated by the modulation transfer function (MTF) which expresses the detector's influence on the SEM image contrast. This is a novel approach, since the MTF was used previously to describe only the area imaging detectors, or whole imaging systems. The measurement technique and calculation of the MTF for the SEM detector are presented. In addition, the measurement and calculation of the detective quantum efficiency (DQE) as a function of the spatial frequency for the SEM detector are described. In this technique, the time modulated e-beam is used in order to create well-defined input signal for the detector. The MTF and DQE measurements are demonstrated on the Everhart-Thornley scintillation detector. This detector was alternated using the YAG:Ce, YAP:Ce, and CRY18 single-crystal scintillators. The presented MTF and DQE characteristics show good imaging properties of the detectors with the YAP:Ce or CRY18 scintillator, especially for a specific type of the e-beam scan. The results demonstrate the great benefit of the description of SEM detectors using the MTF and DQE. In addition, point-by-point and continual-sweep e-beam scans in SEM were discussed and their influence on the image quality was revealed using the MTF.

  1. Quantum efficiency performances of the NIR European Large Format Array detectors tested at ESTEC

    NASA Astrophysics Data System (ADS)

    Crouzet, P.-E.; Duvet, L.; de Wit, F.; Beaufort, T.; Blommaert, S.; Butler, B.; Van Duinkerken, G.; ter Haar, J.; Heijnen, J.; van der Luijt, K.; Smit, H.

    2015-10-01

    Publisher's Note: This paper, originally published on 10/12/2015, was replaced with a corrected/revised version on 10/23/2015. If you downloaded the original PDF but are unable to access the revision, please contact SPIE Digital Library Customer Service for assistance. The Payload Technology Validation Section (SRE-FV) at ESTEC has the goal to validate new technology for future or on-going mission. In this framework, a test set up to characterize the quantum efficiency of near-infrared (NIR) detectors has been created. In the context of the NIR European Large Format Array ("LFA"), 3 deliverables detectors coming from SELEX-UK/ATC (UK) on one side, and CEA/LETI- CEA/IRFU-SOFRADIR (FR) on the other side were characterized. The quantum efficiency of an HAWAII-2RG detector from Teledyne was as well measured. The capability to compare on the same setup detectors from different manufacturers is a unique asset for the future mission preparation office. This publication will present the quantum efficiency results of a HAWAII-2RG detector from Teledyne with a 2.5um cut off compared to the LFA European detectors prototypes developed independently by SELEX-UK/ATC (UK) on one side, and CEA/LETI- CEA/IRFU-SOFRADIR (FR) on the other side.

  2. Quantum parameter estimation in the Unruh-DeWitt detector model

    NASA Astrophysics Data System (ADS)

    Hao, Xiang; Wu, Yinzhong

    2016-09-01

    Relativistic effects on the precision of quantum metrology for particle detectors, such as two-level atoms are studied. The quantum Fisher information is used to estimate the phase sensitivity of atoms in non-inertial motions or in gravitational fields. The Unruh-DeWitt model is applicable to the investigation of the dynamics of a uniformly accelerated atom weakly coupled to a massless scalar vacuum field. When a measuring device is in the same relativistic motion as the atom, the dynamical behavior of quantum Fisher information as a function of Rindler proper time is obtained. It is found out that monotonic decrease in phase sensitivity is characteristic of dynamics of relativistic quantum estimation. The origin of the decay of quantum Fisher information is the thermal bath that the accelerated detector finds itself in due to the Unruh effect. To improve relativistic quantum metrology, we reasonably take into account two reflecting plane boundaries perpendicular to each other. The presence of the reflecting boundary can shield the detector from the thermal bath in some sense.

  3. Superconducting nanowire single-photon detectors integrated with waveguide circuits for quantum information science

    NASA Astrophysics Data System (ADS)

    Gaggero, A.; Sahin, D.; Mattioli, F.; Leoni, R.; Frucci, G.; Jahanmirinejad, S.; Sprengers, J. P.; Beetz, J.; Lermer, M.; Höfling, S.; Kamp, M.; Fiore, A.

    2013-05-01

    We present our progress in the development of an integrated technology suitable for the photonic quantum information processing, showing the first autocorrelator based on two separated detectors integrated on top of the same ridge waveguide. An efficiency of ~1% at 1300 nm for both detectors and independent of the polarization of the incoming photons, is reported. This ultracompact device enables the on-chip measurement of the second-order correlation function g(2)(τ) . We will further discuss ongoing work on the integration of detectors with single-photon sources.

  4. Room temperature single-photon detectors for high bit rate quantum key distribution

    SciTech Connect

    Comandar, L. C.; Patel, K. A.; Fröhlich, B. Lucamarini, M.; Sharpe, A. W.; Dynes, J. F.; Yuan, Z. L.; Shields, A. J.; Penty, R. V.

    2014-01-13

    We report room temperature operation of telecom wavelength single-photon detectors for high bit rate quantum key distribution (QKD). Room temperature operation is achieved using InGaAs avalanche photodiodes integrated with electronics based on the self-differencing technique that increases avalanche discrimination sensitivity. Despite using room temperature detectors, we demonstrate QKD with record secure bit rates over a range of fiber lengths (e.g., 1.26 Mbit/s over 50 km). Furthermore, our results indicate that operating the detectors at room temperature increases the secure bit rate for short distances.

  5. High operating temperature midwave quantum dot barrier infrared detector (QD-BIRD)

    NASA Astrophysics Data System (ADS)

    Ting, David Z.; Soibel, Alexander; Hill, Cory J.; Keo, Sam A.; Mumolo, Jason M.; Gunapala, Sarath D.

    2012-06-01

    The nBn or XBn barrier infrared detector has the advantage of reduced dark current resulting from suppressed Shockley-Read-Hall (SRH) recombination and surface leakage. High performance detectors and focal plane arrays (FPAs) based on InAsSb absorber lattice matched to GaSb substrate, with a matching AlAsSb unipolar electron barrier, have been demonstrated. The band gap of lattice-matched InAsSb yields a detector cutoff wavelength of approximately 4.2 μm when operating at ~150K. We report results on extending the cutoff wavelength of midwave barrier infrared detectors by incorporating self-assembled InSb quantum dots into the active area of the detector. Using this approach, we were able to extend the detector cutoff wavelength to ~6 μm, allowing the coverage of the full midwave infrared (MWIR) transmission window. The quantum dot barrier infrared detector (QD-BIRD) shows infrared response at temperatures up to 225 K.

  6. High Operating Temperature Midwave Quantum Dot Barrier Infrared Detector (QD-BIRD)

    NASA Technical Reports Server (NTRS)

    Ting, David Z.; Soibel, Alexander; Hill, Cory J.; Keo, Sam A.; Mumolo, Jason M.; Gunapala, Sarath D.

    2012-01-01

    The nBn or XBn barrier infrared detector has the advantage of reduced dark current resulting from suppressed Shockley-Read-Hall (SRH) recombination and surface leakage. High performance detectors and focal plane arrays (FPAs) based on InAsSb absorber lattice matched to GaSb substrate, with a matching AlAsSb unipolar electron barrier, have been demonstrated. The band gap of lattice-matched InAsSb yields a detector cutoff wavelength of approximately 4.2 ??m when operating at 150K. We report results on extending the cutoff wavelength of midwave barrier infrared detectors by incorporating self-assembled InSb quantum dots into the active area of the detector. Using this approach, we were able to extend the detector cutoff wavelength to 6 ?m, allowing the coverage of the full midwave infrared (MWIR) transmission window. The quantum dot barrier infrared detector (QD-BIRD) shows infrared response at temperatures up to 225 K.

  7. A detector combining quantum and thermal primary radiometric standards in the same artefact

    NASA Astrophysics Data System (ADS)

    White, M.; Gran, J.; Tomlin, N.; Lehman, J.

    2014-12-01

    We present the concept of a dual-mode primary standard cryogenic detector, utilizing a predictable quantum efficient silicon photodiode, and demonstrate the behaviour of the detector from room temperature down to 30 K. The detector absorbs visible radiation generating either heat or photocurrent, dependent on the selected mode of operation. In effect, this detector links optical power to fundamental constants through the two different routes of operation in the one artefact. Forward biasing of the photodiode is used in lieu of resistive heating to provide the electrical substitution power. The detector has a thermal time constant of 50 s and a sensitivity of 1.39 K mW-1. Using an LED source, we measure equivalence between the two modes of operation of 1.5% at 50 K, limited principally by our knowledge of the wavelength of the emitted radiation of the source.

  8. Quantum cryptography in real-life applications: Assumptions and security

    NASA Astrophysics Data System (ADS)

    Zhao, Yi

    Quantum cryptography, or quantum key distribution (QKD), provides a means of unconditionally secure communication. The security is in principle based on the fundamental laws of physics. Security proofs show that if quantum cryptography is appropriately implemented, even the most powerful eavesdropper cannot decrypt the message from a cipher. The implementations of quantum crypto-systems in real life may not fully comply with the assumptions made in the security proofs. Such discrepancy between the experiment and the theory can be fatal to the security of a QKD system. In this thesis we address a number of these discrepancies. A perfect single-photon source is often assumed in many security proofs. However, a weak coherent source is widely used in a real-life QKD implementation. Decoy state protocols have been proposed as a novel approach to dramatically improve the performance of a weak coherent source based QKD implementation without jeopardizing its security. Here, we present the first experimental demonstrations of decoy state protocols. Our experimental scheme was later adopted by most decoy state QKD implementations. In the security proof of decoy state protocols as well as many other QKD protocols, it is widely assumed that a sender generates a phase-randomized coherent state. This assumption has been enforced in few implementations. We close this gap in two steps: First, we implement and verify the phase randomization experimentally; second, we prove the security of a QKD implementation without the coherent state assumption. In many security proofs of QKD, it is assumed that all the detectors on the receiver's side have identical detection efficiencies. We show experimentally that this assumption may be violated in a commercial QKD implementation due to an eavesdropper's malicious manipulation. Moreover, we show that the eavesdropper can learn part of the final key shared by the legitimate users as a consequence of this violation of the assumptions.

  9. High-efficiency quantum-nondemolition single-photon-number-resolving detector

    SciTech Connect

    Munro, W.J.; Nemoto, Kae; Beausoleil, R.G.; Spiller, T.P.

    2005-03-01

    We discuss an approach to the problem of creating a photon-number-resolving detector using the giant Kerr nonlinearities available in electromagnetically induced transparency. Our scheme can implement a photon-number quantum-nondemolition measurement with high efficiency ({approx}99%) using fewer than 1600 atoms embedded in a dielectric waveguide.

  10. Qubit detection with a T-shaped double quantum dot detector

    NASA Astrophysics Data System (ADS)

    Luo, JunYan; Jiao, HuJun; Hu, Jing; He, Xiao-Ling; Lang, XiaoLi; Wang, Shi-Kuan

    2015-07-01

    We propose to continuously monitor a charge qubit by utilizing a T-shaped double quantum dot detector, in which the qubit and double dot are arranged in such a unique way that the detector turns out to be particularly susceptible to the charge states of the qubit. Special attention is paid to the regime where acquisition of qubit information and backaction upon the measured system exhibit nontrivial correlation. The intrinsic dynamics of the qubit gives rise to dynamical blockade of tunneling events through the detector, resulting in a super-Poissonian noise. However, such a pronounced enhancement of the detector's shot noise does not necessarily produce a rising dephasing rate. In contrast, an inhibition of dephasing is entailed by the reduction of information acquisition in the dynamically blockaded regimes. We further reveal the important impact of the charge fluctuations on the measurement characteristics. Noticeably, under the condition of symmetric junction capacitances the noise pedestal of the circuit current is completely suppressed, leading to a divergent signal-to-noise ratio, and eventually to a violation of the Korotkov-Averin bound in quantum measurement. Our study offers the possibility for a double dot detector to reach the quantum limited effectiveness in a transparent manner.

  11. Quantum-state preparation and macroscopic entanglement in gravitational-wave detectors

    NASA Astrophysics Data System (ADS)

    Müller-Ebhardt, Helge; Rehbein, Henning; Li, Chao; Mino, Yasushi; Somiya, Kentaro; Schnabel, Roman; Danzmann, Karsten; Chen, Yanbei

    2009-10-01

    Long-baseline laser-interferometer gravitational-wave (GW) detectors are operating at a factor of ˜10 (in amplitude) above the standard quantum limit (SQL) within a broad frequency band (in the sense that Δf˜f ). Such a low-noise budget has already allowed the creation of a controlled 2.7 kg macroscopic oscillator with an effective eigenfrequency of 150 Hz and an occupation number of ˜200 . This result, along with the prospect for further improvements, heralds the possibility of experimentally probing macroscopic quantum mechanics (MQM)—quantum mechanical behavior of objects in the realm of everyday experience—using GW detectors. In this paper, we provide the mathematical foundation for the first step of a MQM experiment: the preparation of a macroscopic test mass into a nearly minimum-Heisenberg-limited Gaussian quantum state, which is possible if the interferometer’s classical noise beats the SQL in a broad frequency band. Our formalism, based on Wiener filtering, allows a straightforward conversion from the noise budget of a laser interferometer, in terms of noise spectra, into the strategy for quantum-state preparation and the quality of the prepared state. Using this formalism, we consider how Gaussian entanglement can be built among two macroscopic test masses and the performance of the planned Advanced LIGO interferometers in quantum-state preparation.

  12. Quantum-state preparation and macroscopic entanglement in gravitational-wave detectors

    SciTech Connect

    Mueller-Ebhardt, Helge; Rehbein, Henning; Schnabel, Roman; Danzmann, Karsten; Li Chao; Mino, Yasushi; Chen Yanbei

    2009-10-15

    Long-baseline laser-interferometer gravitational-wave (GW) detectors are operating at a factor of {approx}10 (in amplitude) above the standard quantum limit (SQL) within a broad frequency band (in the sense that {delta}f{approx}f). Such a low-noise budget has already allowed the creation of a controlled 2.7 kg macroscopic oscillator with an effective eigenfrequency of 150 Hz and an occupation number of {approx}200. This result, along with the prospect for further improvements, heralds the possibility of experimentally probing macroscopic quantum mechanics (MQM) - quantum mechanical behavior of objects in the realm of everyday experience - using GW detectors. In this paper, we provide the mathematical foundation for the first step of a MQM experiment: the preparation of a macroscopic test mass into a nearly minimum-Heisenberg-limited Gaussian quantum state, which is possible if the interferometer's classical noise beats the SQL in a broad frequency band. Our formalism, based on Wiener filtering, allows a straightforward conversion from the noise budget of a laser interferometer, in terms of noise spectra, into the strategy for quantum-state preparation and the quality of the prepared state. Using this formalism, we consider how Gaussian entanglement can be built among two macroscopic test masses and the performance of the planned Advanced LIGO interferometers in quantum-state preparation.

  13. Delay discounting of hypothetical monetary rewards with decoys.

    PubMed

    Kowal, Benjamin P; Faulkner, Jennifer L

    2016-01-01

    The current research attempted to decrease individuals' rates of delay discounting by introducing decoys that are similar but inferior to delayed rewards. Two experiments in the current study compared patterns of delay discounting generated by repeated choices between two hypothetical monetary rewards in the absence or presence of a decoy. Binary questionnaires (i.e., decoy absent) included questions with two options: a smaller-sooner (SS) reward and a larger-later (LL) reward. Trinary questionnaires (i.e., decoy present) included questions with three options: an SS reward, an LL reward, and a decoy. If an option is at least as rewarding on every dimension of value as an alternative and the option is more rewarding than an alternative on at least one dimension, then the option is considered to dominate the alternative (Wedell, 1991). The first experiment assessed the influence of decoys dominated by LL rewards (LL(-) decoys), which were constructed to be similar (on the dimension of amount) but inferior (on the dimension of delay) to LL rewards. The second experiment examined the effects of counterbalancing the order of binary and trinary questionnaires. In the first experiment, participants discounted to a lesser degree when LL(-) decoys were present as compared to when they were absent. In the second experiment, participants only discounted to a lesser degree on trinary questionnaires with LL(-) decoys when they had not previously completed binary questionnaires. Patterns of discounting generated by binary questionnaires were similar to those generated by trinary questionnaires when decoys are present; however, the degree to which individuals discounted delayed rewards was affected by the number of and type of options that were available. The current results join previous evidence suggesting that rates of delay discounting are sensitive to a variety of contextual influences. PMID:26521171

  14. Delay discounting of hypothetical monetary rewards with decoys.

    PubMed

    Kowal, Benjamin P; Faulkner, Jennifer L

    2016-01-01

    The current research attempted to decrease individuals' rates of delay discounting by introducing decoys that are similar but inferior to delayed rewards. Two experiments in the current study compared patterns of delay discounting generated by repeated choices between two hypothetical monetary rewards in the absence or presence of a decoy. Binary questionnaires (i.e., decoy absent) included questions with two options: a smaller-sooner (SS) reward and a larger-later (LL) reward. Trinary questionnaires (i.e., decoy present) included questions with three options: an SS reward, an LL reward, and a decoy. If an option is at least as rewarding on every dimension of value as an alternative and the option is more rewarding than an alternative on at least one dimension, then the option is considered to dominate the alternative (Wedell, 1991). The first experiment assessed the influence of decoys dominated by LL rewards (LL(-) decoys), which were constructed to be similar (on the dimension of amount) but inferior (on the dimension of delay) to LL rewards. The second experiment examined the effects of counterbalancing the order of binary and trinary questionnaires. In the first experiment, participants discounted to a lesser degree when LL(-) decoys were present as compared to when they were absent. In the second experiment, participants only discounted to a lesser degree on trinary questionnaires with LL(-) decoys when they had not previously completed binary questionnaires. Patterns of discounting generated by binary questionnaires were similar to those generated by trinary questionnaires when decoys are present; however, the degree to which individuals discounted delayed rewards was affected by the number of and type of options that were available. The current results join previous evidence suggesting that rates of delay discounting are sensitive to a variety of contextual influences.

  15. The role of nanostructures and quantum dots in detectors and solar cells for radiation hardened space applications

    NASA Astrophysics Data System (ADS)

    Taylor, Edward W.

    2006-08-01

    Highly efficient IR detectors and photo-voltaic solar cells that incorporate nanotechnology composed of nanostructures and nanoparticles (including quantum dots) will play an important role in advanced photonic space applications. While the development of Si-based solar cells has successfully evolved into an efficient and economical technology these devices are predicted to soon reach their theoretical 29% limit efficiency. Alternative organic/polymer solar cells and IR detectors incorporating quantum dots and various nanoparticle or nanostructure materials are emerging which are expected to eventually outperform current state-of-the-art detectors and solar cell devices. By tailoring the QD design wavelength-optimized detectors and detector arrays operating over the UV-IR range can be realized. Specific examples for achieving near-IR photovoltaic and photoconductive detectors with high quantum efficiencies are presented along with brief examples of empirical data reported for assessing the radiation resistance of QD nanocrystalline devices for application in space environments.

  16. High-speed, room-temperature quantum cascade detectors at 4.3 μm

    NASA Astrophysics Data System (ADS)

    Zhou, Yuhong; Zhai, Shenqiang; Wang, Fengjiao; Liu, Junqi; Liu, Fengqi; Liu, Shuman; Zhang, Jinchuan; Zhuo, Ning; Wang, Lijun; Wang, ZhanGuo

    2016-03-01

    We present high-speed, room-temperature operated 4.3 μm quantum cascade detectors. The devices are processed as square mesas with 50 Ω coplanar access line and air-bridge connector. The high frequency features are explored using microwave rectification technique and a RLC circuit model. The -3 dB cutoff frequency is experimentally 9 GHz and 4 GHz for 20×20 μm2 and 50×50 μm2 detectors, respectively. The equivalent circuit analysis shows that a second order filter feature governs the devices. Higher cutoff frequency can be achieved by eliminate the parasitics further.

  17. Electronic-state-controlled reset operation in quantum dot resonant-tunneling single-photon detectors

    SciTech Connect

    Weng, Q. C.; Zhu, Z. Q.; An, Z. H.; Song, J. D.; Choi, W. J.

    2014-02-03

    The authors present a systematic study of an introduced reset operation on quantum dot (QD) single photon detectors operating at 77 K. The detectors are based on an AlAs/GaAs/AlAs double-barrier resonant tunneling diode with an adjacent layer of self-assembled InAs QDs. Sensitive single-photon detection in high (dI)/(dV) region with suppressed current fluctuations is achieved. The dynamic detection range is extended up to at least 10{sup 4} photons/s for sensitive imaging applications by keeping the device far from saturation by employing an appropriate reset frequency.

  18. Towards Quantum Experiments with Human Eye Detectors Based on Cloning via Stimulated Emission ?

    NASA Astrophysics Data System (ADS)

    De Martini, Francesco

    2010-05-01

    In a recent theoretical paper published in Physical Review Letters, Sekatsky, Brunner, Branciard, Gisin, Simon report an extended investigation on some properties of the human eye that affect its behavior as a quantum detector. We believe that the content of this work, albeit appealing at fist sight, is highly questionable simply because the human eye cannot be adopted as a sensing device within any quantum measurement apparatus. Furthermore, the criticism raised by these Authors against a real experiment on Micro—Macro entanglement recently published in Physical Review Letters (100, 253601, 2008) is found misleading and misses its target.

  19. Perfect entanglement concentration of an arbitrary four-photon polarization entangled state via quantum nondemolition detectors

    NASA Astrophysics Data System (ADS)

    Wang, Meiyu; Yan, Fengli; Xu, Jingzhou

    2016-08-01

    We show how to concentrate an arbitrary four-photon polarization entangled state into a maximally entangled state based on some quantum nondemolition detectors. The entanglement concentration protocol (ECP) resorts to an ancillary single-photon resource and the conventional projection measurement on photons to assist the concentration, which makes it more economical. Our ECP involves weak cross-Kerr nonlinearities, X homodyne measurement and basic linear-optical elements, which make it feasible in the current experimental technology. Moreover, the ECP considers cyclic utilization to enhance a higher success probability. Thus, our scheme is meaningful in practical applications in quantum communication.

  20. Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses

    PubMed Central

    Hendricks, Gabriel L.; Velazquez, Lourdes; Pham, Serena; Qaisar, Natasha; Delaney, James C.; Viswanathan, Karthik; Albers, Leila; Comolli, James C.; Shriver, Zachary; Knipe, David M.; Kurt-Jones, Evelyn A.; Fygenson, Deborah K.; Trevejo, Jose M.

    2016-01-01

    Heparan sulfate (HS) is a ubiquitous glycosaminoglycan that serves as a cellular attachment site for a number of significant human pathogens, including respiratory syncytial virus (RSV), human parainfluenza virus 3 (hPIV3), and herpes simplex virus (HSV). Decoy receptors can target pathogens by binding to the receptor pocket on viral attachment proteins, acting as ‘molecular sinks’ and preventing the pathogen from binding to susceptible host cells. Decoy receptors functionalized with HS could bind to pathogens and prevent infection, so we generated decoy liposomes displaying HS-octasaccharide (HS-octa). These decoy liposomes significantly inhibited RSV, hPIV3, and HSV infectivity in vitro to a greater degree than the original HS-octa building block. The degree of inhibition correlated with the density of HS-octa displayed on the liposome surface. Decoy liposomes with HS-octa inhibited infection of viruses to a greater extent than either full-length heparin or HS-octa alone. Decoy liposomes were effective when added prior to infection or following the initial infection of cells in vitro. By targeting the well-conserved receptor-binding sites of HS-binding viruses, decoy liposomes functionalized with HS-octa are a promising therapeutic antiviral agent and illustrate the utility of the liposome delivery platform. PMID:25637710

  1. Waveguide integrated superconducting single-photon detectors with high internal quantum efficiency at telecom wavelengths

    PubMed Central

    Kahl, Oliver; Ferrari, Simone; Kovalyuk, Vadim; Goltsman, Gregory N.; Korneev, Alexander; Pernice, Wolfram H. P.

    2015-01-01

    Superconducting nanowire single-photon detectors (SNSPDs) provide high efficiency for detecting individual photons while keeping dark counts and timing jitter minimal. Besides superior detection performance over a broad optical bandwidth, compatibility with an integrated optical platform is a crucial requirement for applications in emerging quantum photonic technologies. Here we present SNSPDs embedded in nanophotonic integrated circuits which achieve internal quantum efficiencies close to unity at 1550 nm wavelength. This allows for the SNSPDs to be operated at bias currents far below the critical current where unwanted dark count events reach milli-Hz levels while on-chip detection efficiencies above 70% are maintained. The measured dark count rates correspond to noise-equivalent powers in the 10−19 W/Hz−1/2 range and the timing jitter is as low as 35 ps. Our detectors are fully scalable and interface directly with waveguide-based optical platforms. PMID:26061283

  2. Security of six-state quantum key distribution protocol with threshold detectors

    NASA Astrophysics Data System (ADS)

    Kato, Go; Tamaki, Kiyoshi

    2016-07-01

    The security of quantum key distribution (QKD) is established by a security proof, and the security proof puts some assumptions on the devices consisting of a QKD system. Among such assumptions, security proofs of the six-state protocol assume the use of photon number resolving (PNR) detector, and as a result the bit error rate threshold for secure key generation for the six-state protocol is higher than that for the BB84 protocol. Unfortunately, however, this type of detector is demanding in terms of technological level compared to the standard threshold detector, and removing the necessity of such a detector enhances the feasibility of the implementation of the six-state protocol. Here, we develop the security proof for the six-state protocol and show that we can use the threshold detector for the six-state protocol. Importantly, the bit error rate threshold for the key generation for the six-state protocol (12.611%) remains almost the same as the one (12.619%) that is derived from the existing security proofs assuming the use of PNR detectors. This clearly demonstrates feasibility of the six-state protocol with practical devices.

  3. Security of six-state quantum key distribution protocol with threshold detectors.

    PubMed

    Kato, Go; Tamaki, Kiyoshi

    2016-01-01

    The security of quantum key distribution (QKD) is established by a security proof, and the security proof puts some assumptions on the devices consisting of a QKD system. Among such assumptions, security proofs of the six-state protocol assume the use of photon number resolving (PNR) detector, and as a result the bit error rate threshold for secure key generation for the six-state protocol is higher than that for the BB84 protocol. Unfortunately, however, this type of detector is demanding in terms of technological level compared to the standard threshold detector, and removing the necessity of such a detector enhances the feasibility of the implementation of the six-state protocol. Here, we develop the security proof for the six-state protocol and show that we can use the threshold detector for the six-state protocol. Importantly, the bit error rate threshold for the key generation for the six-state protocol (12.611%) remains almost the same as the one (12.619%) that is derived from the existing security proofs assuming the use of PNR detectors. This clearly demonstrates feasibility of the six-state protocol with practical devices. PMID:27443610

  4. Security of six-state quantum key distribution protocol with threshold detectors

    PubMed Central

    Kato, Go; Tamaki, Kiyoshi

    2016-01-01

    The security of quantum key distribution (QKD) is established by a security proof, and the security proof puts some assumptions on the devices consisting of a QKD system. Among such assumptions, security proofs of the six-state protocol assume the use of photon number resolving (PNR) detector, and as a result the bit error rate threshold for secure key generation for the six-state protocol is higher than that for the BB84 protocol. Unfortunately, however, this type of detector is demanding in terms of technological level compared to the standard threshold detector, and removing the necessity of such a detector enhances the feasibility of the implementation of the six-state protocol. Here, we develop the security proof for the six-state protocol and show that we can use the threshold detector for the six-state protocol. Importantly, the bit error rate threshold for the key generation for the six-state protocol (12.611%) remains almost the same as the one (12.619%) that is derived from the existing security proofs assuming the use of PNR detectors. This clearly demonstrates feasibility of the six-state protocol with practical devices. PMID:27443610

  5. Security of six-state quantum key distribution protocol with threshold detectors.

    PubMed

    Kato, Go; Tamaki, Kiyoshi

    2016-07-22

    The security of quantum key distribution (QKD) is established by a security proof, and the security proof puts some assumptions on the devices consisting of a QKD system. Among such assumptions, security proofs of the six-state protocol assume the use of photon number resolving (PNR) detector, and as a result the bit error rate threshold for secure key generation for the six-state protocol is higher than that for the BB84 protocol. Unfortunately, however, this type of detector is demanding in terms of technological level compared to the standard threshold detector, and removing the necessity of such a detector enhances the feasibility of the implementation of the six-state protocol. Here, we develop the security proof for the six-state protocol and show that we can use the threshold detector for the six-state protocol. Importantly, the bit error rate threshold for the key generation for the six-state protocol (12.611%) remains almost the same as the one (12.619%) that is derived from the existing security proofs assuming the use of PNR detectors. This clearly demonstrates feasibility of the six-state protocol with practical devices.

  6. 4.3 μm quantum cascade detector in pixel configuration.

    PubMed

    Harrer, A; Schwarz, B; Schuler, S; Reininger, P; Wirthmüller, A; Detz, H; MacFarland, D; Zederbauer, T; Andrews, A M; Rothermund, M; Oppermann, H; Schrenk, W; Strasser, G

    2016-07-25

    We present the design simulation and characterization of a quantum cascade detector operating at 4.3μm wavelength. Array integration and packaging processes were investigated. The device operates in the 4.3μm CO2 absorption region and consists of 64 pixels. The detector is designed fully compatible to standard processing and material growth methods for scalability to large pixel counts. The detector design is optimized for a high device resistance at elevated temperatures. A QCD simulation model was enhanced for resistance and responsivity optimization. The substrate illuminated pixels utilize a two dimensional Au diffraction grating to couple the light to the active region. A single pixel responsivity of 16mA/W at room temperature with a specific detectivity D* of 5⋅107 cmHz/W was measured. PMID:27464155

  7. High quantum-efficiency photon-number-resolving detector for photonic on-chip information processing.

    PubMed

    Calkins, Brice; Mennea, Paolo L; Lita, Adriana E; Metcalf, Benjamin J; Kolthammer, W Steven; Lamas-Linares, Antia; Spring, Justin B; Humphreys, Peter C; Mirin, Richard P; Gates, James C; Smith, Peter G R; Walmsley, Ian A; Gerrits, Thomas; Nam, Sae Woo

    2013-09-23

    The integrated optical circuit is a promising architecture for the realization of complex quantum optical states and information networks. One element that is required for many of these applications is a high-efficiency photon detector capable of photon-number discrimination. We present an integrated photonic system in the telecom band at 1550 nm based on UV-written silica-on-silicon waveguides and modified transition-edge sensors capable of number resolution and over 40 % efficiency. Exploiting the mode transmission failure of these devices, we multiplex three detectors in series to demonstrate a combined 79 % ± 2 % detection efficiency with a single pass, and 88 % ± 3 % at the operating wavelength of an on-chip terminal reflection grating. Furthermore, our optical measurements clearly demonstrate no significant unexplained loss in this system due to scattering or reflections. This waveguide and detector design therefore allows the placement of number-resolving single-photon detectors of predictable efficiency at arbitrary locations within a photonic circuit - a capability that offers great potential for many quantum optical applications. PMID:24104153

  8. Quantum variational measurement and the optical lever intracavity topology of gravitational-wave detectors

    SciTech Connect

    Khalili, F. Ya.

    2007-04-15

    The intracavity topologies of laser gravitational-wave detectors proposed several years ago are the promising way to obtain sensitivity of these devices significantly better than the Standard Quantum Limit (SQL). In essence, the intracavity detector is a two-stage device where the end mirrors displacement created by the gravitational wave is transferred to the displacement of an additional local mirror by means of the optical rigidity. The local mirror positions have to be monitored by an additional local meter. It is evident that the local meter precision defines the sensitivity of the detector. To overcome the SQL, the quantum variational measurement can be used in the local meter. In this method a frequency-dependent correlation between the meter backaction noise and measurement noise is introduced, which allows us to eliminate the backaction noise component from the meter output signal. This correlation is created by means of an additional filter cavity. In this article the sensitivity limitations of this scheme imposed by the optical losses both in the local meter itself and in the filter cavity are estimated. It is shown that the main sensitivity limitation stems from the filter cavity losses. In order to overcome it, it is necessary to increase the filter cavity length. In a preliminary prototype experiment, an approximate 10 m long filter cavity can be used to obtain sensitivity approximately 2-3 times better than the SQL. For future Quantum Non-Demolition (QND) gravitational-wave detectors with sensitivity about 10 times better than the SQL, the filter cavity length should be within kilometer range.

  9. Quantum variational measurement and the optical lever intracavity topology of gravitational-wave detectors

    NASA Astrophysics Data System (ADS)

    Khalili, F. Ya.

    2007-04-01

    The intracavity topologies of laser gravitational-wave detectors proposed several years ago are the promising way to obtain sensitivity of these devices significantly better than the Standard Quantum Limit (SQL). In essence, the intracavity detector is a two-stage device where the end mirrors displacement created by the gravitational wave is transferred to the displacement of an additional local mirror by means of the optical rigidity. The local mirror positions have to be monitored by an additional local meter. It is evident that the local meter precision defines the sensitivity of the detector. To overcome the SQL, the quantum variational measurement can be used in the local meter. In this method a frequency-dependent correlation between the meter backaction noise and measurement noise is introduced, which allows us to eliminate the backaction noise component from the meter output signal. This correlation is created by means of an additional filter cavity. In this article the sensitivity limitations of this scheme imposed by the optical losses both in the local meter itself and in the filter cavity are estimated. It is shown that the main sensitivity limitation stems from the filter cavity losses. In order to overcome it, it is necessary to increase the filter cavity length. In a preliminary prototype experiment, an approximate 10 m long filter cavity can be used to obtain sensitivity approximately 2 3 times better than the SQL. For future Quantum Non-Demolition (QND) gravitational-wave detectors with sensitivity about 10 times better than the SQL, the filter cavity length should be within kilometer range.

  10. Wavelength sensitive detector based on ICD in two coupled quantum wells

    NASA Astrophysics Data System (ADS)

    Goldzak, Tamar; Gilary, Ido; Moiseyev, Nimrod

    2014-05-01

    We design a wavelength sensitive detector based on inter coulombic decay (ICD) mechanism in a two-quantum well nano-structure. The two coupled quantum wells are designed to satisfy the specific conditions which allow the ICD to occur. In this setup, by absorbing light an electron in one well is excited. Its relaxation back to the ground state is a non-radiative process which transfers the excess energy to the ionization of the electron in the neighboring well into the continuum. Only radiation with a specific wavelength will be absorbed, when the wavelength matches the excitation energy in the quantum well. By applying a weak bias a current is obtained even when light with a very low intensity is absorbed. For the ICD to be dominant decay mechanism it must prevail over all other possible competitive decay processes. We have found that the lifetime of the ICD is on the timescale of picoseconds. Control over the ICD lifetime can be achieved by variation of different parameters in the two quantum well nano-structure. The most useful parameter is the distance between the two quantum wells. We show that as the distance decreases the decay rate of the ICD increases. Furthermore the distance can be tuned such that the emitted electron would be in a metastable state in the continuum (a resonance state); this causes the life time of the ICD to be an order of magnitude smaller, and improves the efficiency of the ICD.

  11. Development and application of InAsP/InP quantum well infrared detector

    NASA Astrophysics Data System (ADS)

    Geetanjali, Porwal, S.; Kumar, R.; Dixit, V. K.; Sharma, T. K.; Oak, S. M.

    2016-05-01

    InAsxP1-x/InP quantum wells grown using metal organic vapor phase epitaxy are investigated for infrared detector applications. The structural parameters of the QWs are evaluated from high resolution x-ray diffraction. The electronic transition energies measured from surface photo voltage and photoconductivity confirms that these QWs can be used for fabricating IR detectors in the wide wavelength range, i.e. 0.9-1.46 µm by inter-band transitions and 7-18 µm by inter-sub-band transitions. Subsequently the functionality of one such fabricated InAsxP1-x/InPQW detector is verified by measuring the photoluminescence of suitable semiconductor quantum well structure. At the request of all authors of the paper, and with the agreement of the Proceedings Editor, an updated version of this article was published on 24 June 2016. The original version supplied to AIP Publishing contained an error in the Figures 1 and 2 where the right side of the images were cutoff. The error has been corrected in the updated and re-published article.

  12. Assessment of semiempirical enthalpy of formation in solution as an effective energy function to discriminate native-like structures in protein decoy sets.

    PubMed

    Urquiza-Carvalho, Gabriel Aires; Fragoso, Wallace Duarte; Rocha, Gerd Bruno

    2016-08-01

    In this work, we tested the PM6, PM6-DH+, PM6-D3, and PM7 enthalpies of formation in aqueous solution as scoring functions across 33 decoy sets to discriminate native structures or good models in a decoy set. In each set these semiempirical quantum chemistry methods were compared according to enthalpic and geometric criteria. Enthalpically, we compared the methods according to how much lower was the enthalpy of each native, when compared with the mean enthalpy of its set. Geometrically, we compared the methods according to the fraction of native contacts (Q), which is a measure of geometric closeness between an arbitrary structure and the native. For each set and method, the Q of the best decoy was compared with the Q0 , which is the Q of the decoy closest to the native in the set. It was shown that the PM7 method is able to assign larger energy differences between the native structure and the decoys in a set, arguably because of a better description of dispersion interactions, however PM6-DH+ was slightly better than the rest at selecting geometrically good models in the absence of a native structure in the set. © 2016 Wiley Periodicals, Inc.

  13. Assessment of semiempirical enthalpy of formation in solution as an effective energy function to discriminate native-like structures in protein decoy sets.

    PubMed

    Urquiza-Carvalho, Gabriel Aires; Fragoso, Wallace Duarte; Rocha, Gerd Bruno

    2016-08-01

    In this work, we tested the PM6, PM6-DH+, PM6-D3, and PM7 enthalpies of formation in aqueous solution as scoring functions across 33 decoy sets to discriminate native structures or good models in a decoy set. In each set these semiempirical quantum chemistry methods were compared according to enthalpic and geometric criteria. Enthalpically, we compared the methods according to how much lower was the enthalpy of each native, when compared with the mean enthalpy of its set. Geometrically, we compared the methods according to the fraction of native contacts (Q), which is a measure of geometric closeness between an arbitrary structure and the native. For each set and method, the Q of the best decoy was compared with the Q0 , which is the Q of the decoy closest to the native in the set. It was shown that the PM7 method is able to assign larger energy differences between the native structure and the decoys in a set, arguably because of a better description of dispersion interactions, however PM6-DH+ was slightly better than the rest at selecting geometrically good models in the absence of a native structure in the set. © 2016 Wiley Periodicals, Inc. PMID:27249629

  14. Sagnac interferometer as a speed-meter-type, quantum-nondemolition gravitational-wave detector

    NASA Astrophysics Data System (ADS)

    Chen, Yanbei

    2003-06-01

    According to quantum measurement theory, “speed meters”—devices that measure the momentum, or speed, of free test masses—are immune to the standard quantum limit (SQL). It is shown that a Sagnac-interferometer gravitational-wave detector is a speed meter and therefore in principle it can beat the SQL by large amounts over a wide band of frequencies. It is shown, further, that, when one ignores optical losses, a signal-recycled Sagnac interferometer with Fabry-Perot arm cavities has precisely the same performance, for the same circulating light power, as the Michelson speed-meter interferometer recently invented and studied by Purdue and the author. The influence of optical losses is not studied, but it is plausible that they be fairly unimportant for the Sagnac interferometer, as for other speed meters. With squeezed vacuum (squeeze factor e-2R=0.1) injected into its dark port, the recycled Sagnac interferometer can beat the SQL by a factor (10)≃3 over the frequency band 10 Hz≲f≲150 Hz using the same circulating power Ic˜820 kW as is to be used by the (quantum limited) second-generation Advanced LIGO interferometers—if other noise sources are made sufficiently small. It is concluded that the Sagnac optical configuration, with signal recycling and squeezed-vacuum injection, is an attractive candidate for third-generation interferometric gravitational-wave detectors (LIGO-III and EURO).

  15. Detectors

    DOEpatents

    Orr, Christopher Henry; Luff, Craig Janson; Dockray, Thomas; Macarthur, Duncan Whittemore; Bounds, John Alan; Allander, Krag

    2002-01-01

    The apparatus and method provide techniques through which both alpha and beta emission determinations can be made simultaneously using a simple detector structure. The technique uses a beta detector covered in an electrically conducting material, the electrically conducting material discharging ions generated by alpha emissions, and as a consequence providing a measure of those alpha emissions. The technique also offers improved mountings for alpha detectors and other forms of detectors against vibration and the consequential effects vibration has on measurement accuracy.

  16. Detective quantum efficiency: a standard test to ensure optimal detector performance and low patient exposures

    NASA Astrophysics Data System (ADS)

    Escartin, Terenz R.; Nano, Tomi F.; Cunningham, Ian A.

    2016-03-01

    The detective quantum efficiency (DQE), expressed as a function of spatial frequency, describes the ability of an x-ray detector to produce high signal-to-noise ratio (SNR) images. While regulatory and scientific communities have used the DQE as a primary metric for optimizing detector design, the DQE is rarely used by end users to ensure high system performance is maintained. Of concern is that image quality varies across different systems for the same exposures with no current measures available to describe system performance. Therefore, here we conducted an initial DQE measurement survey of clinical x-ray systems using a DQE-testing instrument to identify their range of performance. Following laboratory validation, experiments revealed that the DQE of five different systems under the same exposure level (8.0 μGy) ranged from 0.36 to 0.75 at low spatial frequencies, and 0.02 to 0.4 at high spatial frequencies (3.5 cycles/mm). Furthermore, the DQE dropped substantially with decreasing detector exposure by a factor of up to 1.5x in the lowest spatial frequency, and a factor of 10x at 3.5 cycles/mm due to the effect of detector readout noise. It is concluded that DQE specifications in purchasing decisions, combined with periodic DQE testing, are important factors to ensure patients receive the health benefits of high-quality images for low x-ray exposures.

  17. A heuristic approach to the quantum measurement problem: How to distinguish particle detectors from ordinary objects

    NASA Astrophysics Data System (ADS)

    Merlin, R.

    2015-08-01

    Elementary particle detectors fall broadly into only two classes: phase-transformation devices, such as the bubble chamber, and charge-transfer devices like the Geiger-Müller tube. Quantum measurements are seen to involve transitions from a long-lived metastable state (e.g., superheated liquid or a gas of atoms between charged capacitor plates) to a thermodynamically stable condition. A detector is then a specially prepared object undergoing a metastable-to-stable transformation that is significantly enhanced by the presence of the measured particle, which behaves, in some sense, as the seed of a process of heterogeneous nucleation. Based on this understanding of the operation of a conventional detector, and using results of orthogonality-catastrophe theory, we argue that, in the thermodynamic limit, the pre-measurement Hamiltonian is not the same as that describing the detector during or after the interaction with a particle and, thus, that superpositions of pointer states (Schrödinger’s cats) are unphysical because their time evolution is ill defined. Examples of particle-induced changes in the Hamiltonian are also given for ordinary systems whose macroscopic parameters are susceptible to radiation damage, but are not modified by the interaction with a single particle.

  18. Mid/far-infrared photo-detectors based on graphene asymmetric quantum wells

    NASA Astrophysics Data System (ADS)

    Ben Salem, E.; Chaabani, R.; Jaziri, S.

    2016-09-01

    We conducted a theoretical study on the electronic properties of a single-layer graphene asymmetric quantum well. Quantification of energy levels is limited by electron–hole conversion at the barrier interfaces and free-electron continuum. Electron–hole conversion at the barrier interfaces can be controlled by introducing an asymmetry between barriers and taking into account the effect of the interactions of the graphene sheet with the substrate. The interaction with the substrate induces an effective mass to carriers, allowing observation of Fabry–Pérot resonances under normal incidence and extinction of Klein tunneling. The asymmetry, between barriers creates a transmission gap between confined states and free-electron continuum, allowing the large graphene asymmetric quantum well to be exploited as a photo-detector operating at mid- and far-infrared frequency regimes.

  19. Mid/far-infrared photo-detectors based on graphene asymmetric quantum wells

    NASA Astrophysics Data System (ADS)

    Ben Salem, E.; Chaabani, R.; Jaziri, S.

    2016-09-01

    We conducted a theoretical study on the electronic properties of a single-layer graphene asymmetric quantum well. Quantification of energy levels is limited by electron-hole conversion at the barrier interfaces and free-electron continuum. Electron-hole conversion at the barrier interfaces can be controlled by introducing an asymmetry between barriers and taking into account the effect of the interactions of the graphene sheet with the substrate. The interaction with the substrate induces an effective mass to carriers, allowing observation of Fabry-Pérot resonances under normal incidence and extinction of Klein tunneling. The asymmetry, between barriers creates a transmission gap between confined states and free-electron continuum, allowing the large graphene asymmetric quantum well to be exploited as a photo-detector operating at mid- and far-infrared frequency regimes.

  20. Detective quantum efficiency of photon-counting x-ray detectors

    SciTech Connect

    Tanguay, Jesse; Yun, Seungman; Kim, Ho Kyung; Cunningham, Ian A.

    2015-01-15

    Purpose: Single-photon-counting (SPC) x-ray imaging has the potential to improve image quality and enable novel energy-dependent imaging methods. Similar to conventional detectors, optimizing image SPC quality will require systems that produce the highest possible detective quantum efficiency (DQE). This paper builds on the cascaded-systems analysis (CSA) framework to develop a comprehensive description of the DQE of SPC detectors that implement adaptive binning. Methods: The DQE of SPC systems can be described using the CSA approach by propagating the probability density function (PDF) of the number of image-forming quanta through simple quantum processes. New relationships are developed to describe PDF transfer through serial and parallel cascades to accommodate scatter reabsorption. Results are applied to hypothetical silicon and selenium-based flat-panel SPC detectors including the effects of reabsorption of characteristic/scatter photons from photoelectric and Compton interactions, stochastic conversion of x-ray energy to secondary quanta, depth-dependent charge collection, and electronic noise. Results are compared with a Monte Carlo study. Results: Depth-dependent collection efficiency can result in substantial broadening of photopeaks that in turn may result in reduced DQE at lower x-ray energies (20–45 keV). Double-counting interaction events caused by reabsorption of characteristic/scatter photons may result in falsely inflated image signal-to-noise ratio and potential overestimation of the DQE. Conclusions: The CSA approach is extended to describe signal and noise propagation through photoelectric and Compton interactions in SPC detectors, including the effects of escape and reabsorption of emission/scatter photons. High-performance SPC systems can be achieved but only for certain combinations of secondary conversion gain, depth-dependent collection efficiency, electronic noise, and reabsorption characteristics.

  1. Nanowire superconducting single-photon detectors on GaAs for integrated quantum photonic applications

    NASA Astrophysics Data System (ADS)

    Gaggero, A.; Nejad, S. Jahanmiri; Marsili, F.; Mattioli, F.; Leoni, R.; Bitauld, D.; Sahin, D.; Hamhuis, G. J.; Nötzel, R.; Sanjines, R.; Fiore, A.

    2010-10-01

    We demonstrate efficient nanowire superconducting single photon detectors (SSPDs) based on NbN thin films grown on GaAs. NbN films ranging from 3 to 5 nm in thickness have been deposited by dc magnetron sputtering on GaAs substrates at 350 °C. These films show superconducting properties comparable to similar films grown on sapphire and MgO. In order to demonstrate the potential for monolithic integration, SSPDs were fabricated and measured on GaAs/AlAs Bragg mirrors, showing a clear cavity enhancement, with a peak quantum efficiency of 18.3% at λ =1300 nm and T=4.2 K.

  2. Dark current in GaAs/AlxGa1-xAs quantum well infrared detectors

    NASA Astrophysics Data System (ADS)

    Nathan, Vaidya

    2013-01-01

    It is not clear whether the tunneling current in QWIPs depends just on the energy corresponding to motion perpendicular to the plane of the quantum well or on the total energy. In order to get a quantitative assessment of the contribution of energy corresponding to motion in the plane of the quantum well to the dark current we use the following approach. We calculate the dark current in GaAs/AlxGa1-x s quantum well infrared detectors for both tunneling dependent only on Ez, and tunneling dependent on the total energy, and compare the results to experimental data. Comparison of theoretical results with experimental data at 40K shows that motion in the plane of the quantum well plays a significant role in determining the tunneling dark current. Corrections are made to Levine's original formula. Variation of the dark current with barrier width and doping density is systematically studied. It is shown that increasing the barrier width and/or decreasing the doping density in the well do not always reduce the dark current.

  3. Maximizing the quantum efficiency of microchannel plate detectors - The collection of photoelectrons from the interchannel web using an electric field

    NASA Technical Reports Server (NTRS)

    Taylor, R. C.; Hettrick, M. C.; Malina, R. F.

    1983-01-01

    High quantum efficiency and two-dimensional imaging capabilities make the microchannel plate (MCP) a suitable detector for a sky survey instrument. The Extreme Ultraviolet Explorer satellite, to be launched in 1987, will use MCP detectors. A feature which limits MCP efficiency is related to the walls of individual channels. The walls are of finite thickness and thus form an interchannel web. Under normal circumstances, this web does not contribute to the detector's quantum efficiency. Panitz and Foesch (1976) have found that in the case of a bombardment with ions, electrons were ejected from the electrode material coating the web. By applying a small electric field, the electrons were returned to the MCP surface where they were detected. The present investigation is concerned with the enhancement of quantum efficiencies in the case of extreme UV wavelengths. Attention is given to a model and a computer simulation which quantitatively reproduce the experimental results.

  4. Study of infrared point source simulator for generating the multi-decoy

    NASA Astrophysics Data System (ADS)

    Zeng, Chang-e.; Yang, Di; Su, Jian-gang; Huang, Yan-jun; Wang, Zhi-sheng

    2013-08-01

    The hardware-in-loop test system for infrared point-type guide missile was introduced;The decoy irradiation and motion characteristics were analyzed; multi-decoy generation mode and principle were studied.

  5. Quantum Zeno effect in cavity quantum electrodynamics: Experimental proposal with nonideal cavities and detectors

    NASA Astrophysics Data System (ADS)

    Rossi, R., Jr.; de Magalhães, A. R. Bosco; Nemes, M. C.

    2008-01-01

    We propose an experiment for the observation of the quantum Zeno effect (QZE) in a bipartite system. The setup involves two microwave cavities and a “tunneling” photon, which is observed by the passage of Rydberg atoms. Our proposal allows for the consideration of two types of measurements, namely, sequential observations of the atomic state and its inclusive measurement. In the present system the two processes are shown to lead to the same result in the ideal case. We consider realistic atom-field interaction times, cavity dissipation, and limited detection efficiency. Analytical expressions for the “tunneling” probability are obtained exhibiting a competition between the environment induced exponential decay and the characteristic t2 (for short times) dependence of the QZE. We show that for sufficiently small dissipation constants the effect can be observed with current experimental facilities.

  6. Effectiveness of spinning-wing decoys varies among dabbling duck species and locations

    USGS Publications Warehouse

    Ackerman, J.T.; Eadie, J.M.; Szymanski, M.L.; Caswell, J.H.; Vrtiska, Mark P.; Raedeke, Andrew H.; Checkett, J.M.; Afton, A.D.; Moore, T.G.; Caswell, F.D.; Walters, R.A.; Humburg, D.D.; Yee, J.L.

    2006-01-01

    Spinning-wing decoys are strong attractants to ducks and inc rease kill rates over traditional decoying methods. However, it is unknown whether all duck species are attracted similarly to spinning-wing decoys and whether the effectiveness of these decoys changes with latitude. We examined the effectiveness of spinning-wing decoys for 9 species of dabbling ducks during 545 experimental hunts in California (1999-2000), Minnesota (2002), Manitoba (2001-2002), Nebraska (2000-2002), Missouri (2000-2001), and Arkansas (2001-2003). During each experimental hunt, we systematically alternated between 2 paired decoy treatments every 15-30 min (depending on study site): traditional decoys only and traditional decoys with a spinning-wing decoy. Overall, 70.2% (n=1,925) of dabbling ducks were harvested (shot and retrieved) when spinning-wing decoys were turned on, ranging from 63.6% (n=187) in Missouri to 76.4% (n=356) in Minnesota. Effectiveness of spinning-wing decoys increased with latitude of study sites. Proportions of ducks shot when spinning-wing decoys were turned on differed among species, from a low of 50.0% (n=8) for cinnamon teal (Anas cyanoptera) to a high of 79.0% (n=119) for American wigeon (A. americana). The probability of being shot when spinning-wing decoys were turned on increased with annual survival rates among species; for example, spinning-wing decoys were more effective for American wigeon and mallard (A. platyrhynchos) than they were for cinnamon teal and American green-winged teal (A. crecca). Effectiveness of spinning-wing decoys did not differ consistently by age or sex of harvested ducks. Our results indicate that the effectiveness of spinning-wing decoys differs among duck species and changes with latitude; thus, consideration of these effects may be warranted when setting harvest regulations and methods of take.

  7. Up-conversion detectors at 1550 nm for quantum communication: review and recent advances

    NASA Astrophysics Data System (ADS)

    Tournier, M.; Alibart, O.; Doutre, F.; Tascu, S.; de Micheli, M. P.; Ostrowsky, D. B.; Thyagarajan, K.; Tanzilli, S.

    Up-conversion, or hybrid, detectors have been investigated in quantum communication experiments to replace Indium-Gallium-Arsenide avalanche photodiodes (InGaAs-APD) for the detection of infrared and telecom single photons. Those detectors are based on the supposedly noise-free process of frequency up-conversion, also called sum-frequency generation (SFG), using a second order (χ^2) non-linear crystal. Powered by an intense pump laser, this process permits transposing with a certain probability the single photons at telecom wavelengths to the visible range where silicon APDs (Si-APD) operate with a much better performance than InGaAs detectors. To date, the literature reports up-conversion detectors having efficiency and noise figures comparable to that of the best commercially available IngaAs-APDs. However, in all of these previous realizations, a pump-induced noise is always observed which was initially expected to be as low as the dark count level of the Si-APDs. Although this additional noise represents a problem for the detection, up-conversion detectors have advantageously replaced InGaAs-APDs in various long-distance quantum cryptography schemes since they offer a continuous regime operation mode instead of a gated mode necessary for InGaAs-APDs, and the possibility of much higher counting rates. Despite attempted explanations, no detailed nor conclusive study of this noise has been reported. The aim of this paper is to offer a definitive explanation for this noise. We first give a review of the state of the art by describing already demonstrated up-conversion detectors. We discuss these realizations especially regarding the choices made for the material, in bulk or guided configurations, the single photon wavelengths, and the pump scheme. Then we describe an original device made of waveguides integrated on periodically poled lithium niobate (PPLN)or on single-domain lithium niobate aimed at investigating the origin of the additional pump-induced noise

  8. Exact expressions for thermal contrast detected with thermal and quantum detectors

    NASA Astrophysics Data System (ADS)

    Stewart, Seán. M.; Johnson, R. Barry

    2014-10-01

    The detected thermal contrast is a recently defined figure of merit introduced to describe the overall performance of a detector detecting radiation from a thermal source. We examine the detected thermal contrast for the case where the target emissivity can be assumed to be a function of the temperature and independent of the wavelength within a narrow wavelength interval of interest. Exact expressions are developed to evaluate the thermal contrast detected by both thermal and quantum detectors for focal-plane radiation detecting instruments. Expressions for the thermal contrast of a blackbody, an intrinsic radiative quantity of a body independent of the detection process, and simplified expressions for the detected thermal contrast for target emissivities which are well approximated by the grey body approximation are also given. It is found the contribution in the detected thermal contrast consists of two terms. The first results from changes occurring in the emissivity of a target with temperature while the second results from purely radiative processes. The size of the detected thermal contrast is found to be similar for the two detector types within typical infrared wavelength intervals of interest, contradicting a result previously reported in the literature. The exact results are presented in terms of a polylogarithmic formulation of the problem and extend a number of approximation schemes that have been proposed and developed in the past.

  9. Detector-device-independent quantum key distribution: Security analysis and fast implementation

    NASA Astrophysics Data System (ADS)

    Boaron, Alberto; Korzh, Boris; Houlmann, Raphael; Boso, Gianluca; Lim, Charles Ci Wen; Martin, Anthony; Zbinden, Hugo

    2016-08-01

    One of the most pressing issues in quantum key distribution (QKD) is the problem of detector side-channel attacks. To overcome this problem, researchers proposed an elegant "time-reversal" QKD protocol called measurement-device-independent QKD (MDI-QKD), which is based on time-reversed entanglement swapping. However, MDI-QKD is more challenging to implement than standard point-to-point QKD. Recently, an intermediary QKD protocol called detector-device-independent QKD (DDI-QKD) has been proposed to overcome the drawbacks of MDI-QKD, with the hope that it would eventually lead to a more efficient detector side-channel-free QKD system. Here, we analyze the security of DDI-QKD and elucidate its security assumptions. We find that DDI-QKD is not equivalent to MDI-QKD, but its security can be demonstrated with reasonable assumptions. On the more practical side, we consider the feasibility of DDI-QKD and present a fast experimental demonstration (clocked at 625 MHz), capable of secret key exchange up to more than 90 km.

  10. Real-World Two-Photon Interference and Proof-of-Principle Quantum Key Distribution Immune to Detector Attacks

    NASA Astrophysics Data System (ADS)

    Rubenok, A.; Slater, J. A.; Chan, P.; Lucio-Martinez, I.; Tittel, W.

    2013-09-01

    Several vulnerabilities of single-photon detectors have recently been exploited to compromise the security of quantum-key-distribution (QKD) systems. In this Letter, we report the first proof-of-principle implementation of a new quantum-key-distribution protocol that is immune to any such attack. More precisely, we demonstrated this new approach to QKD in the laboratory over more than 80 km of spooled fiber, as well as across different locations within the city of Calgary. The robustness of our fiber-based implementation, together with the enhanced level of security offered by the protocol, confirms QKD as a realistic technology for safeguarding secrets in transmission. Furthermore, our demonstration establishes the feasibility of controlled two-photon interference in a real-world environment and thereby removes a remaining obstacle to realizing future applications of quantum communication, such as quantum repeaters and, more generally, quantum networks.

  11. High detectivity short-wavelength II-VI quantum cascade detector

    SciTech Connect

    Ravikumar, Arvind P. Gmachl, Claire F.; Garcia, Thor A.; Tamargo, Maria C.; Jesus, Joel De

    2014-08-11

    We report on the experimental demonstration of a ZnCdSe/ZnCdMgSe-based short-wavelength photovoltaic Quantum Cascade Detector (QCD). The QCD operates in two spectral bands centered around 2.6 μm and 3.6 μm. Calibrated blackbody measurements yield a peak responsivity of 0.1 mA/W or 2400 V/W at 80 K, and a corresponding 300 K background radiation limited infrared performance detectivity (BLIP) of ∼2.5 × 10{sup 10 }cm √Hz/W. Comparison of background illuminated and dark current-voltage measurements demonstrates a BLIP temperature of 200 K. The device differential resistance-area product, decreases from about 10{sup 6} Ω cm{sup 2} at 80 K to about 8000 Ω cm{sup 2} at 300 K, indicative of the ultra-low Johnson noise in the detectors.

  12. Integrated semiconductor quantum dot scintillation detector: Ultimate limit for speed and light yield

    DOE PAGES

    Oktyabrsky, Serge; Yakimov, Michael; Tokranov, Vadim; Murat, Pavel

    2016-03-30

    Here, a picosecond-range timing of charged particles and photons is a long-standing challenge for many high-energy physics, biophysics, medical and security applications. We present a design, technological pathway and challenges, and some properties important for realization of an ultrafast high-efficient room-temperature semiconductor scintillator based on self-assembled InAs quantum dots (QD) embedded in a GaAs matrix. Low QD density (<; 1015 cm-3), fast (~5 ps) electron capture, luminescence peak redshifted by 0.2-0.3 eV from GaAs absorption edge with fast decay time (0.5-1 ns) along with the efficient energy transfer in the GaAs matrix (4.2 eV/pair) allows for fabrication of a semiconductormore » scintillator with the unsurpassed performance parameters. The major technological challenge is fabrication of a large volume (> 1 cm3 ) of epitaxial QD medium. This requires multiple film separation and bonding, likely using separate epitaxial films as waveguides for improved light coupling. Compared to traditional inorganic scintillators, the semiconductor-QD based scintillators could have about 5x higher light yield and 20x faster decay time, opening a way to gamma detectors with the energy resolution better than 1% and sustaining counting rates MHz. Picosecond-scale timing requires segmented low-capacitance photodiodes integrated with the scintillator. For photons, the proposed detector inherently provides the depth-of-interaction information.« less

  13. The iQID Camera: An Ionizing-Radiation Quantum Imaging Detector

    DOE PAGES

    Miller, Brian W.; Gregory, Stephanie J.; Fuller, Erin S.; Barrett, Harrison H.; Barber, Bradford H.; Furenlid, Lars R.

    2014-06-11

    We have developed and tested a novel, ionizing-radiation Quantum Imaging Detector (iQID). This scintillation-based detector was originally developed as a high-resolution gamma-ray imager, called BazookaSPECT, for use in single-photon emission computed tomography (SPECT). Recently, we have investigated the detectors response and imaging potential with other forms of ionizing radiation including alpha, neutron, beta, and fission fragment particles. The detector’s response to a broad range of ionizing radiation has prompted its new title. The principle operation of the iQID camera involves coupling a scintillator to an image intensifier. The scintillation light generated particle interactions is optically amplified by the intensifier andmore » then re-imaged onto a CCD/CMOS camera sensor. The intensifier provides sufficient optical gain that practically any CCD/CMOS camera can be used to image ionizing radiation. Individual particles are identified and their spatial position (to sub-pixel accuracy) and energy are estimated on an event-by-event basis in real time using image analysis algorithms on high-performance graphics processing hardware. Distinguishing features of the iQID camera include portability, large active areas, high sensitivity, and high spatial resolution (tens of microns). Although modest, iQID has energy resolution that is sufficient to discrimate between particles. Additionally, spatial features of individual events can be used for particle discrimination. An important iQID imaging application that has recently been developed is single-particle, real-time digital autoradiography. In conclusion, we present the latest results and discuss potential applications.« less

  14. The iQID Camera: An Ionizing-Radiation Quantum Imaging Detector

    SciTech Connect

    Miller, Brian W.; Gregory, Stephanie J.; Fuller, Erin S.; Barrett, Harrison H.; Barber, Bradford H.; Furenlid, Lars R.

    2014-06-11

    We have developed and tested a novel, ionizing-radiation Quantum Imaging Detector (iQID). This scintillation-based detector was originally developed as a high-resolution gamma-ray imager, called BazookaSPECT, for use in single-photon emission computed tomography (SPECT). Recently, we have investigated the detectors response and imaging potential with other forms of ionizing radiation including alpha, neutron, beta, and fission fragment particles. The detector’s response to a broad range of ionizing radiation has prompted its new title. The principle operation of the iQID camera involves coupling a scintillator to an image intensifier. The scintillation light generated particle interactions is optically amplified by the intensifier and then re-imaged onto a CCD/CMOS camera sensor. The intensifier provides sufficient optical gain that practically any CCD/CMOS camera can be used to image ionizing radiation. Individual particles are identified and their spatial position (to sub-pixel accuracy) and energy are estimated on an event-by-event basis in real time using image analysis algorithms on high-performance graphics processing hardware. Distinguishing features of the iQID camera include portability, large active areas, high sensitivity, and high spatial resolution (tens of microns). Although modest, iQID has energy resolution that is sufficient to discrimate between particles. Additionally, spatial features of individual events can be used for particle discrimination. An important iQID imaging application that has recently been developed is single-particle, real-time digital autoradiography. In conclusion, we present the latest results and discuss potential applications.

  15. Quantum efficiency measurement of the Transiting Exoplanet Survey Satellite (TESS) CCD detectors

    NASA Astrophysics Data System (ADS)

    Krishnamurthy, A.; Villasenor, J.; Thayer, C.; Kissel, S.; Ricker, G.; Seager, S.; Lyle, R.; Deline, A.; Morgan, E.; Sauerwein, T.; Vanderspek, R.

    2016-07-01

    Very precise on-ground characterization and calibration of TESS CCD detectors will significantly assist in the analysis of the science data from the mission. An accurate optical test bench with very high photometric stability has been developed to perform precise measurements of the absolute quantum efficiency. The setup consists of a vacuum dewar with a single MIT Lincoln Lab CCID-80 device mounted on a cold plate with the calibrated reference photodiode mounted next to the CCD. A very stable laser-driven light source is integrated with a closed-loop intensity stabilization unit to control variations of the light source down to a few parts-per-million when averaged over 60 s. Light from the stabilization unit enters a 20 inch integrating sphere. The output light from the sphere produces near-uniform illumination on the cold CCD and on the calibrated reference photodiode inside the dewar. The ratio of the CCD and photodiode signals provides the absolute quantum efficiency measurement. The design, key features, error analysis, and results from the test campaign are presented.

  16. Realizing the measure-device-independent quantum-key-distribution with passive heralded-single photon sources

    PubMed Central

    Wang, Qin; Zhou, Xing-Yu; Guo, Guang-Can

    2016-01-01

    In this paper, we put forward a new approach towards realizing measurement-device-independent quantum key distribution with passive heralded single-photon sources. In this approach, both Alice and Bob prepare the parametric down-conversion source, where the heralding photons are labeled according to different types of clicks from the local detectors, and the heralded ones can correspondingly be marked with different tags at the receiver’s side. Then one can obtain four sets of data through using only one-intensity of pump light by observing different kinds of clicks of local detectors. By employing the newest formulae to do parameter estimation, we could achieve very precise prediction for the two-single-photon pulse contribution. Furthermore, by carrying out corresponding numerical simulations, we compare the new method with other practical schemes of measurement-device-independent quantum key distribution. We demonstrate that our new proposed passive scheme can exhibit remarkable improvement over the conventional three-intensity decoy-state measurement-device-independent quantum key distribution with either heralded single-photon sources or weak coherent sources. Besides, it does not need intensity modulation and can thus diminish source-error defects existing in several other active decoy-state methods. Therefore, if taking intensity modulating errors into account, our new method will show even more brilliant performance. PMID:27759085

  17. Experimental measurement-device-independent quantum key distribution.

    PubMed

    Liu, Yang; Chen, Teng-Yun; Wang, Liu-Jun; Liang, Hao; Shentu, Guo-Liang; Wang, Jian; Cui, Ke; Yin, Hua-Lei; Liu, Nai-Le; Li, Li; Ma, Xiongfeng; Pelc, Jason S; Fejer, M M; Peng, Cheng-Zhi; Zhang, Qiang; Pan, Jian-Wei

    2013-09-27

    Quantum key distribution is proven to offer unconditional security in communication between two remote users with ideal source and detection. Unfortunately, ideal devices never exist in practice and device imperfections have become the targets of various attacks. By developing up-conversion single-photon detectors with high efficiency and low noise, we faithfully demonstrate the measurement-device-independent quantum-key-distribution protocol, which is immune to all hacking strategies on detection. Meanwhile, we employ the decoy-state method to defend attacks on a nonideal source. By assuming a trusted source scenario, our practical system, which generates more than a 25 kbit secure key over a 50 km fiber link, serves as a stepping stone in the quest for unconditionally secure communications with realistic devices. PMID:24116758

  18. Experimental Measurement-Device-Independent Quantum Key Distribution

    NASA Astrophysics Data System (ADS)

    Liu, Yang; Chen, Teng-Yun; Wang, Liu-Jun; Liang, Hao; Shentu, Guo-Liang; Wang, Jian; Cui, Ke; Yin, Hua-Lei; Liu, Nai-Le; Li, Li; Ma, Xiongfeng; Pelc, Jason S.; Fejer, M. M.; Peng, Cheng-Zhi; Zhang, Qiang; Pan, Jian-Wei

    2013-09-01

    Quantum key distribution is proven to offer unconditional security in communication between two remote users with ideal source and detection. Unfortunately, ideal devices never exist in practice and device imperfections have become the targets of various attacks. By developing up-conversion single-photon detectors with high efficiency and low noise, we faithfully demonstrate the measurement-device-independent quantum-key-distribution protocol, which is immune to all hacking strategies on detection. Meanwhile, we employ the decoy-state method to defend attacks on a nonideal source. By assuming a trusted source scenario, our practical system, which generates more than a 25 kbit secure key over a 50 km fiber link, serves as a stepping stone in the quest for unconditionally secure communications with realistic devices.

  19. Development of a Quantum Cascade Laser-Based Detector for Ammonia and Nitric Acid

    SciTech Connect

    Zahniser, Mark S.; Nelson, David D.; McManus, J. Barry; Shorter, Joanne H.; Herndon, Scott C.; Jimenez, Rodrigo

    2005-12-31

    We have developed a compact, robust, atmospheric trace gas detector based on mid-infrared absorption spectroscopy using pulsed quantum cascade (QC) lasers. The spectrometer is suitable for airborne measurements of ammonia, nitric acid, formaldehyde, formic acid, methane, nitrous oxide, carbon monoxide, nitrogen dioxide and other gases that have line-resolved absorption spectra in the mid-infrared spectral region. The QC laser light source operates near room temperature with thermal electric cooling instead of liquid nitrogen which has been previously required for semiconductor lasers in the mid-infrared spectral region. The QC lasers have sufficient output power so that thermal electric cooled detectors may be used in many applications with lower precision requirements. The instrument developed in this program has been used in several field campaigns from both the Aerodyne Mobile Laboratory and from the NOAA WP3 aircraft. The Phase II program has resulted in more than 10 archival publications describing the technology and its applications. Over 12 instruments based on this design have been sold to research groups in Europe and the United States making the program both a commercial as well as a technological success. Anticipated Benefits The development of a sensitive, cryogen-free, mid-infrared absorption method for atmospheric trace gas detection will have wide benefits for atmospheric and environmental research and broader potential commercial applications in areas such as medical diagnostic and industrial process monitoring of gaseous compounds. Examples include air pollution monitoring, breath analysis, combustion exhaust diagnostics, and plasma diagnostics for semi-conductor fabrication. The substitution of near-room temperature QC lasers for cryogenic lead salt TDLs and the resulting simplifications in instrument design and operation will greatly expand the range of applications.

  20. The iQID camera: An ionizing-radiation quantum imaging detector

    PubMed Central

    Miller, Brian W.; Gregory, Stephanie J.; Fuller, Erin S.; Barrett, Harrison H.; Barber, H. Bradford; Furenlid, Lars R.

    2015-01-01

    We have developed and tested a novel, ionizing-radiation Quantum Imaging Detector (iQID). This scintillation-based detector was originally developed as a high-resolution gamma-ray imager, called BazookaSPECT, for use in single-photon emission computed tomography (SPECT). Recently, we have investigated the detector’s response and imaging potential with other forms of ionizing radiation including alpha, neutron, beta, and fission fragment particles. The confirmed response to this broad range of ionizing radiation has prompted its new title. The principle operation of the iQID camera involves coupling a scintillator to an image intensifier. The scintillation light generated by particle interactions is optically amplified by the intensifier and then re-imaged onto a CCD/CMOS camera sensor. The intensifier provides sufficient optical gain that practically any CCD/CMOS camera can be used to image ionizing radiation. The spatial location and energy of individual particles are estimated on an event-by-event basis in real time using image analysis algorithms on high-performance graphics processing hardware. Distinguishing features of the iQID camera include portability, large active areas, excellent detection efficiency for charged particles, and high spatial resolution (tens of microns). Although modest, iQID has energy resolution that is sufficient to discriminate between particles. Additionally, spatial features of individual events can be used for particle discrimination. An important iQID imaging application that has recently been developed is real-time, single-particle digital autoradiography. We present the latest results and discuss potential applications. PMID:26166921

  1. Decoy activity through microRNAs: the therapeutic implications

    PubMed Central

    Almeida, Maria Ines; Reis, Rui Manuel; Calin, George Adrian

    2013-01-01

    Introduction microRNAs (miRNAs), small noncoding RNAs, are deregulated in several diseases including cancer. miRNAs regulate gene expression at a post-transcriptional level by binding to 5′UTR, coding regions or 3′UTR of messenger RNAs (mRNA), inhibiting mRNA translation or causing mRNA degradation. The same miRNA can have multiple mRNA targets, and the same mRNA can be regulated by various miRNAs. Areas covered Recently, seminal contributions by several groups have implicated miRNAs as components of an RNA–RNA language that involves crosstalk between competing endogenous RNAs through a decoy mechanism. We review the studies that described miRNAs as players in a biological decoy activity. miRNAs can either be trapped by competing endogenous RNAs or interact with proteins that have binding sites for mRNAs. Expert opinion The miRNA decoy functions have implications for the design of therapeutic approaches in human diseases, including specific ways to overcome resistance to drug therapy and future miRNA-based clinical trials design. PMID:22650365

  2. Measurement device-independent quantum key distribution with heralded pair coherent state

    NASA Astrophysics Data System (ADS)

    Chen, Dong; Shang-Hong, Zhao; Lei, Shi

    2016-10-01

    The original measurement device-independent quantum key distribution is reviewed, and a modified protocol using heralded pair coherent state (HPCS) is proposed to overcome the quantum bit error rate associated with the dark count rate of the detectors in long-distance quantum key distribution. Our simulation indicates that the secure transmission distance can be improved evidently with HPCS owing to the lower probability of vacuum events when compared with weak coherent source scenario, while the secure key rate can be increased with HPCS due to the higher probability of single-photon events when compared with heralded single-photon source scenario. Furthermore, we apply the finite key analysis to the decoy state MDI-QKD with HPCS and obtain a practical key rate.

  3. Measurement device-independent quantum key distribution with heralded pair coherent state

    NASA Astrophysics Data System (ADS)

    Chen, Dong; Shang-Hong, Zhao; Lei, Shi

    2016-07-01

    The original measurement device-independent quantum key distribution is reviewed, and a modified protocol using heralded pair coherent state (HPCS) is proposed to overcome the quantum bit error rate associated with the dark count rate of the detectors in long-distance quantum key distribution. Our simulation indicates that the secure transmission distance can be improved evidently with HPCS owing to the lower probability of vacuum events when compared with weak coherent source scenario, while the secure key rate can be increased with HPCS due to the higher probability of single-photon events when compared with heralded single-photon source scenario. Furthermore, we apply the finite key analysis to the decoy state MDI-QKD with HPCS and obtain a practical key rate.

  4. Fiber-coupled quantum-communications receiver based on two NbN superconducting single-photon detectors

    NASA Astrophysics Data System (ADS)

    Slysz, W.; Wegrzecki, M.; Bar, J.; Grabiec, P.; Górska, M.; Latta, C.; Zwiller, V.; Pearlman, A.; Cross, A.; Korneev, A.; Kouminov, P.; Smirnov, K.; Voronov, B.; Gol'tsman, G.; Verevkin, A.; Currie, M.; Sobolewski, R.

    2005-09-01

    We present the design and performance of a novel, two-channel single-photon receiver, based on two fiber-coupled NbN superconducting single-photon detectors (SSPDs). The SSPDs are nanostructured superconducting meanders covering an area of 100 μm2 and are known for ultrafast and efficient counting of single, visible-to-infrared photons. Their operation has been explained within a phenomenological hot-electron photoresponse model. Our receiver is intended for fiber-based quantum cryptography and communication systems, operational at near-infrared (NIR) telecommunication wavelengths, λ = 1.3 μm and λ = 1.55 μm. Coupling between the NbN detector and a single-mode optical fiber was achieved using a specially designed, micromechanical photoresist ring, positioned directly over the SSPD active area. The positioning accuracy of the ring was below 1 μm. The receiver with SSPDs was placed (immersed) in a standard liquid-helium transport Dewar and kept without interruption for over two months at 4.2 K. At the same time, the optical fiber inputs and electrical outputs were kept at room temperature. Our best system reached a system quantum efficiency of up to 0.3 % in the NIR radiation range, with the detector coupling efficiency of about 30 %. The response time was measured to be about 250 ps and was limited by our read-out electronics. The measured jitter was close to 35 ps. The presented performance parameters show that our NIR single photon detectors are suitable for practical quantum cryptography and for applications in quantum-correlation experiments.

  5. Electron-phonon interaction in three-barrier nanosystems as active elements of quantum cascade detectors

    SciTech Connect

    Tkach, N. V. Seti, Ju. A.; Grynyshyn, Yu. B.

    2015-04-15

    The theory of electron tunneling through an open nanostructure as an active element of a quantum cascade detector is developed, which takes into account the interaction of electrons with confined and interface phonons. Using the method of finite-temperature Green’s functions and the electron-phonon Hamiltonian in the representation of second quantization over all system variables, the temperature shifts and electron-level widths are calculated and the contributions of different electron-phonon-interaction mechanisms to renormalization of the spectral parameters are analyzed depending on the geometrical configuration of the nanosystem. Due to weak electron-phonon coupling in a GaAs/Al{sub 0.34}Ga{sub 0.66}As-based resonant tunneling nanostructure, the temperature shift and rf field absorption peak width are not very sensitive to the electron-phonon interaction and result from a decrease in potential barrier heights caused by a difference in the temperature dependences of the well and barrier band gaps.

  6. A decoy trap for breeding-season mallards in North Dakota

    USGS Publications Warehouse

    Sharp, D.E.; Lokemoen, J.T.

    1987-01-01

    A modified decoy trap was effective for capturing wild adult male and female mallards (Anas platyrhynchos) during the 1980-81 breeding seasons in North Dakota. Key features contributing to the trap's success included a central decoy cylinder, large capture compartments with spring-door openings, an adjustable trigger mechanism with a balanced door attachment that was resistant to trap movement, and the use of F1, wild-stock or game-farm female decoys.

  7. Estimation of losses in a 300 m filter cavity and quantum noise reduction in the KAGRA gravitational-wave detector

    NASA Astrophysics Data System (ADS)

    Capocasa, Eleonora; Barsuglia, Matteo; Degallaix, Jérôme; Pinard, Laurent; Straniero, Nicolas; Schnabel, Roman; Somiya, Kentaro; Aso, Yoichi; Tatsumi, Daisuke; Flaminio, Raffaele

    2016-04-01

    The sensitivity of the gravitational-wave detector KAGRA, presently under construction, will be limited by quantum noise in a large fraction of its spectrum. The most promising technique to increase the detector sensitivity is the injection of squeezed states of light, where the squeezing angle is dynamically rotated by a Fabry-Pérot filter cavity. One of the main issues in the filter cavity design and realization is the optical losses due to the mirror surface imperfections. In this work we present a study of the specifications for the mirrors to be used in a 300 m filter cavity for the KAGRA detector. A prototype of the cavity will be constructed at the National Astronomical Observatory of Japan, inside the infrastructure of the former TAMA interferometer. We also discuss the potential improvement of the KAGRA sensitivity, based on a model of various realistic sources of losses and their influence on the squeezing amplitude.

  8. Spectrum-based method to generate good decoy libraries for spectral library searching in peptide identifications.

    PubMed

    Cheng, Chia-Ying; Tsai, Chia-Feng; Chen, Yu-Ju; Sung, Ting-Yi; Hsu, Wen-Lian

    2013-05-01

    As spectral library searching has received increasing attention for peptide identification, constructing good decoy spectra from the target spectra is the key to correctly estimating the false discovery rate in searching against the concatenated target-decoy spectral library. Several methods have been proposed to construct decoy spectral libraries. Most of them construct decoy peptide sequences and then generate theoretical spectra accordingly. In this paper, we propose a method, called precursor-swap, which directly constructs decoy spectral libraries directly at the "spectrum level" without generating decoy peptide sequences by swapping the precursors of two spectra selected according to a very simple rule. Our spectrum-based method does not require additional efforts to deal with ion types (e.g., a, b or c ions), fragment mechanism (e.g., CID, or ETD), or unannotated peaks, but preserves many spectral properties. The precursor-swap method is evaluated on different spectral libraries and the results of obtained decoy ratios show that it is comparable to other methods. Notably, it is efficient in time and memory usage for constructing decoy libraries. A software tool called Precursor-Swap-Decoy-Generation (PSDG) is publicly available for download at http://ms.iis.sinica.edu.tw/PSDG/.

  9. Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation.

    PubMed

    Bonecchi, Raffaella; Garlanda, Cecilia; Mantovani, Alberto; Riva, Federica

    2016-11-01

    IL-1R2 was the first decoy receptor to be described. Subsequently receptors which act as pure decoys or scavengers or trigger dampening of cytokine signaling have been described for cytokines and chemokines. Here we review the current understanding of the mode of action and significance in pathology of the chemokine atypical receptor ACKR2, the IL-1 decoy receptor IL-1R2 and the atypical IL-1 receptor family IL-1R8. Decoy and scavenger receptors with no or atypical signaling have emerged as a general strategy conserved in evolution to tune the action of cytokines, chemokines and growth factors. PMID:27498604

  10. Teleportation of a general two-mode coherent-state superposition via attenuated quantum channels with ideal and/or threshold detectors

    NASA Astrophysics Data System (ADS)

    An, Nguyen Ba

    2009-04-01

    Three novel probabilistic yet conclusive schemes are proposed to teleport a general two-mode coherent-state superposition via attenuated quantum channels with ideal and/or threshold detectors. The calculated total success probability is highest (lowest) when only ideal (threshold) detectors are used.

  11. High quantum efficiency megavoltage imaging with thick scintillator detectors for image guided radiation therapy

    NASA Astrophysics Data System (ADS)

    Gopal, Arun

    In image guided radiation therapy (IGRT), imaging devices serve as guidance systems to aid patient set-up and tumor volume localization. Traditionally, 2-D megavoltage x-ray imagers, referred to as electronic portal imaging devices (EPIDs), have been used for planar target localization, and have recently been extended to perform 3-D volumetric reconstruction via cone-beam computed tomography (CBCT). However, current EPIDs utilize thin and inefficient phosphor screen detectors and are subsequently limited by poor soft tissue visualization, which limits their use for CBCT. Therefore, the use of thick scintillation media as megavoltage x-ray detectors for greater x-ray sensitivity and enhanced image quality has recently been of significant interest. In this research, two candidates for thick scintillators: CsI(Tl) and terbium doped scintillation glass were investigated in separate imaging configurations. In the first configuration, a thick scintillation crystal (TSC) consisting of a thick, monolithic slab of CsI(Tl) was coupled to a mirror-lens-camera system. The second configuration is based on a fiber-optic scintillation glass array (FOSGA), wherein the scintillation glass is drawn into long fiber-optic conduits, inserted into a grid-type housing constructed out of polymer-tungsten alloy, and coupled to an array of photodiodes for digital read-out. The imaging prototypes were characterized using theoretical studies and imaging measurements to obtain fundamental metrics of imaging performance. Spatial resolution was measured based on a modulation transfer function (MTF), noise was evaluated in terms of a noise power spectrum (NPS), and overall contrast was characterized in the form of detective quantum efficiency (DQE). The imaging studies were used to optimize the TSC and FOSGA imagers and propose prototype configurations for order-of-magnitude improvements in overall image quality. In addition, a fast and simple technique was developed to measure the MTF, NPS, and

  12. Simulation and analysis of grating-integrated quantum dot infrared detectors for spectral response control and performance enhancement

    SciTech Connect

    Oh Kim, Jun; Ku, Zahyun; Urbas, Augustine E-mail: Augustine.Urbas@wpafb.af.mil; Krishna, Sanjay; Kang, Sang-Woo; Jun Lee, Sang; Chul Jun, Young E-mail: Augustine.Urbas@wpafb.af.mil

    2014-04-28

    We propose and analyze a novel detector structure for pixel-level multispectral infrared imaging. More specifically, we investigate the device performance of a grating-integrated quantum dots-in-a-well photodetector under backside illumination. Our design uses 1-dimensional grating patterns fabricated directly on a semiconductor contact layer and, thus, adds a minimal amount of additional effort to conventional detector fabrication flows. We show that we can gain wide-range control of spectral response as well as large overall detection enhancement by adjusting grating parameters. For small grating periods, the spectral responsivity gradually changes with parameters. We explain this spectral tuning using the Fabry–Perot resonance and effective medium theory. For larger grating periods, the responsivity spectra get complicated due to increased diffraction into the active region, but we find that we can obtain large enhancement of the overall detector performance. In our design, the spectral tuning range can be larger than 1 μm, and, compared to the unpatterned detector, the detection enhancement can be greater than 92% and 148% for parallel and perpendicular polarizations. Our work can pave the way for practical, easy-to-fabricate detectors, which are highly useful for many infrared imaging applications.

  13. The detective quantum efficiency of photon-counting x-ray detectors using cascaded-systems analyses

    SciTech Connect

    Tanguay, Jesse; Yun, Seungman; Kim, Ho Kyung; Cunningham, Ian A.

    2013-04-15

    Purpose: Single-photon counting (SPC) x-ray imaging has the potential to improve image quality and enable new advanced energy-dependent methods. The purpose of this study is to extend cascaded-systems analyses (CSA) to the description of image quality and the detective quantum efficiency (DQE) of SPC systems. Methods: Point-process theory is used to develop a method of propagating the mean signal and Wiener noise-power spectrum through a thresholding stage (required to identify x-ray interaction events). The new transfer relationships are used to describe the zero-frequency DQE of a hypothetical SPC detector including the effects of stochastic conversion of incident photons to secondary quanta, secondary quantum sinks, additive noise, and threshold level. Theoretical results are compared with Monte Carlo calculations assuming the same detector model. Results: Under certain conditions, the CSA approach can be applied to SPC systems with the additional requirement of propagating the probability density function describing the total number of image-forming quanta through each stage of a cascaded model. Theoretical results including DQE show excellent agreement with Monte Carlo calculations under all conditions considered. Conclusions: Application of the CSA method shows that false counts due to additive electronic noise results in both a nonlinear image signal and increased image noise. There is a window of allowable threshold values to achieve a high DQE that depends on conversion gain, secondary quantum sinks, and additive noise.

  14. Adaptation of Decoy Fusion Strategy for Existing Multi-Stage Search Workflows.

    PubMed

    Ivanov, Mark V; Levitsky, Lev I; Gorshkov, Mikhail V

    2016-09-01

    A number of proteomic database search engines implement multi-stage strategies aiming at increasing the sensitivity of proteome analysis. These approaches often employ a subset of the original database for the secondary stage of analysis. However, if target-decoy approach (TDA) is used for false discovery rate (FDR) estimation, the multi-stage strategies may violate the underlying assumption of TDA that false matches are distributed uniformly across the target and decoy databases. This violation occurs if the numbers of target and decoy proteins selected for the second search are not equal. Here, we propose a method of decoy database generation based on the previously reported decoy fusion strategy. This method allows unbiased TDA-based FDR estimation in multi-stage searches and can be easily integrated into existing workflows utilizing popular search engines and post-search algorithms. Graphical Abstract ᅟ. PMID:27349255

  15. Adaptation of Decoy Fusion Strategy for Existing Multi-Stage Search Workflows

    NASA Astrophysics Data System (ADS)

    Ivanov, Mark V.; Levitsky, Lev I.; Gorshkov, Mikhail V.

    2016-09-01

    A number of proteomic database search engines implement multi-stage strategies aiming at increasing the sensitivity of proteome analysis. These approaches often employ a subset of the original database for the secondary stage of analysis. However, if target-decoy approach (TDA) is used for false discovery rate (FDR) estimation, the multi-stage strategies may violate the underlying assumption of TDA that false matches are distributed uniformly across the target and decoy databases. This violation occurs if the numbers of target and decoy proteins selected for the second search are not equal. Here, we propose a method of decoy database generation based on the previously reported decoy fusion strategy. This method allows unbiased TDA-based FDR estimation in multi-stage searches and can be easily integrated into existing workflows utilizing popular search engines and post-search algorithms.

  16. Adaptation of Decoy Fusion Strategy for Existing Multi-Stage Search Workflows.

    PubMed

    Ivanov, Mark V; Levitsky, Lev I; Gorshkov, Mikhail V

    2016-09-01

    A number of proteomic database search engines implement multi-stage strategies aiming at increasing the sensitivity of proteome analysis. These approaches often employ a subset of the original database for the secondary stage of analysis. However, if target-decoy approach (TDA) is used for false discovery rate (FDR) estimation, the multi-stage strategies may violate the underlying assumption of TDA that false matches are distributed uniformly across the target and decoy databases. This violation occurs if the numbers of target and decoy proteins selected for the second search are not equal. Here, we propose a method of decoy database generation based on the previously reported decoy fusion strategy. This method allows unbiased TDA-based FDR estimation in multi-stage searches and can be easily integrated into existing workflows utilizing popular search engines and post-search algorithms. Graphical Abstract ᅟ.

  17. Development of a portable instrument for automated measurements of the detective quantum efficiency of x-ray detectors

    NASA Astrophysics Data System (ADS)

    Cunningham, I. A.; Lazarev, S.; Sattarivand, M.; Jankovic, N. D.

    2007-03-01

    The scientific community has generally adopted use of the modulation transfer function (MTF) and detective quantum efficiency (DQE) as primary measures of performance of radiographic detectors. However, measurement of these parameters is generally restricted to experts in laboratory environments due to the required x-ray physics knowledge, specialized instrumentation and computational analyses. We have developed a prototype instrument that automates both the physical measurement and subsequent image analysis to determine the MTF, noise power spectrum (NPS) and DQE of radiographic and mammographic systems. The instrument is placed in the x-ray path directly in front of the detector. A series of images are acquired, saved in "raw" DICOM format and then used to determine the MTF (using the slanted-edge method) and NPS. The number of incident quanta is calculated from measurements of the incident exposure including corrections for air temperature and pressure and ionization chamber spectral response. The primary sources of error are backscatter from the detector and scatter generated within the instrument. These have been minimized to achieve an incident exposure measurement within 2% of a calibrated electrometer and chamber in free space. The MTF and DQE of a commercial CsI-based flat-panel detector were measured over a range of incident exposures from 20 uR to 20 mR per image. Results agreed with both our own laboratory measurements and previously published measurements performed elsewhere with a similar detector within 2% for the MTF and 5% for the DQE. A complete DQE analysis of a clinical digital flat-panel detector is completed in 30 minutes and requires no system modifications.

  18. Continuous-variable quantum identity authentication based on quantum teleportation

    NASA Astrophysics Data System (ADS)

    Ma, Hongxin; Huang, Peng; Bao, Wansu; Zeng, Guihua

    2016-06-01

    A continuous-variable quantum identity authentication protocol, which is based on quantum teleportation, is presented by employing two-mode squeezed vacuum state and coherent state. The proposed protocol can verify user's identity efficiently with a new defined fidelity parameter. Update of authentication key can also be implemented in our protocol. Moreover, the analysis shows its feasibility and security under the general Gaussian-cloner attack on authentication key, which is guaranteed by quantum entanglement, insertion of decoy state and random displacement.

  19. Enhanced quantum efficiency of high-purity silicon imaging detectors by ultralow temperature surface modification using Sb doping

    NASA Technical Reports Server (NTRS)

    Blacksberg, Jordana; Hoenk, Michael E.; Elliott, S. Tom; Holland, Stephen E.; Nikzad, Shouleh

    2005-01-01

    A low temperature process for Sb doping of silicon has been developed as a backsurface treatment for high-purity n-type imaging detectors. Molecular beam epitaxy (MBE) is used to achieve very high dopant incorporation in a thin, surface-confined layer. The growth temperature is kept below 450 (deg)C for compatibility with Al-metallized devices. Imaging with MBE-modified 1kx1k charge coupled devices (CCDs) operated in full depletion has been demonstrated. Dark current is comparable to the state-of-the-art process, which requires a high temperature step. Quantum efficiency is improved, especially in the UV, for thin doped layers placed closer to the backsurface. Near 100% internal quantum efficiency has been demonstrated in the ultraviolet for a CCD with a 1.5 nm silicon cap layer.

  20. Design of monocrystalline Si/SiGe multi-quantum well microbolometer detector for infrared imaging systems

    NASA Astrophysics Data System (ADS)

    Shafique, Atia; Durmaz, Emre C.; Cetindogan, Barbaros; Yazici, Melik; Kaynak, Mehmet; Kaynak, Canan B.; Gurbuz, Yasar

    2016-05-01

    This paper presents the design, modelling and simulation results of silicon/silicon-germanium (Si/SiGe) multi-quantum well based bolometer detector for uncooled infrared imaging system. The microbolometer is designed to detect light in the long wave length infrared (LWIR) range from 8 to 14 μm with pixel size of 25 x 25 μm. The design optimization strategy leads to achieve the temperature coefficient of resistance (TCR) 4.5%/K with maximum germanium (Ge) concentration of 50%. The design of microbolometer entirely relies on standard CMOS and MEMS processes which makes it suitable candidate for commercial infrared imaging systems.

  1. Manipulating and understanding antibiotic production in Streptomyces coelicolor A3(2) with decoy oligonucleotides.

    PubMed

    McArthur, Michael; Bibb, Mervyn J

    2008-01-22

    We have adapted and extended the decoy oligonucleotide technique for use in prokaryotes. To identify cis-acting regulatory elements within a promoter, we developed a DNase I/T7 exonuclease footprinting technique and applied it to actII-orf4 from Streptomyces coelicolor A3(2), which encodes the pathway-specific activator for production of the antibiotic actinorhodin. Our in vivo mapping data allowed us to create decoy oligonucleotides incorporating the identified regulatory elements and to test whether their introduction into S. coelicolor affected antibiotic production. We mapped the promoter region when in a transcriptionally inactive state before the onset of actinorhodin production with the aim of designing decoy oligonucleotides capable of interfering with potential repressor binding and so stimulate actinorhodin production. Mapping identified five candidates for decoy oligonucleotides, and these were tested in a plate-based assay to rapidly validate their activity. A transfection protocol was developed for liquid cultures that enabled efficient uptake of decoys, and quantitative real-time PCR demonstrated decoy persistence for >70 h. Measurement of the effects on growth, expression of actII-orf4, and antibiotic production demonstrated that one of the decoys, in concordance with the plate assay, was more efficacious than the others in increasing actinorhodin production. Two of the identified regulatory elements occurred upstream of gene SCO5812, deletion of which reduced actinorhodin production, confirming that experimental analysis of regulatory motifs can provide new insights into factors influencing antibiotic production in streptomycetes.

  2. Three Temperature Regimes in Superconducting Photon Detectors: Quantum, Thermal and Multiple Phase-Slips as Generators of Dark Counts

    PubMed Central

    Murphy, Andrew; Semenov, Alexander; Korneev, Alexander; Korneeva, Yulia; Gol’tsman, Gregory; Bezryadin, Alexey

    2015-01-01

    We perform measurements of the switching current distributions of three w ≈ 120 nm wide, 4 nm thick NbN superconducting strips which are used for single-photon detectors. These strips are much wider than the diameter of the vortex cores, so they are classified as quasi-two-dimensional (quasi-2D). We discover evidence of macroscopic quantum tunneling by observing the saturation of the standard deviation of the switching distributions at temperatures around 2 K. We analyze our results using the Kurkijärvi-Garg model and find that the escape temperature also saturates at low temperatures, confirming that at sufficiently low temperatures, macroscopic quantum tunneling is possible in quasi-2D strips and can contribute to dark counts observed in single photon detectors. At the highest temperatures the system enters a multiple phase-slip regime. In this range single phase-slips are unable to produce dark counts and the fluctuations in the switching current are reduced. PMID:25988591

  3. Quantum efficiencies of imaging detectors with alkali halide photocathodes. I - Microchannel plates with separate and integral CsI photocathodes

    NASA Technical Reports Server (NTRS)

    Carruthers, George R.

    1987-01-01

    Measurements and comparisons have been made of the quantum efficiencies of microchannel plate (MCP) detectors in the far-UV (below 2000-A) wavelength range using CsI photocathodes (a) deposited on the front surfaces of microchannel plates and (b) deposited on solid substrates as opaque photocathodes with the resulting photoelectrons input to microchannel plates. The efficiences were measured in both pulse-counting and photodiode modes of operation. Typical efficiencies are about 15 percent at 1216 A for a CsI-coated MCP compared with 65 percent for an opaque CsI photocathode MCP detector. Special processing has yielded an efficiency as high as 20 percent for a CsI-coated MCP. This may possibly be further improved by optimization of the tilt angle of the MCP channels relative to the front face of the MCP and incident radiation. However, at present there still remains a factor of at least 3 quantum efficiency advantage in the separate opaque CsI photocathode configuration.

  4. Fine-scale features on bioreplicated decoys of the emerald ash borer provide necessary visual verisimilitude

    NASA Astrophysics Data System (ADS)

    Domingue, Michael J.; Pulsifer, Drew P.; Narkhede, Mahesh S.; Engel, Leland G.; Martín-Palma, Raúl J.; Kumar, Jayant; Baker, Thomas C.; Lakhtakia, Akhlesh

    2014-03-01

    The emerald ash borer (EAB), Agrilus planipennis, is an invasive tree-killing pest in North America. Like other buprestid beetles, it has an iridescent coloring, produced by a periodically layered cuticle whose reflectance peaks at 540 nm wavelength. The males perform a visually mediated ritualistic mating flight directly onto females poised on sunlit leaves. We attempted to evoke this behavior using artificial visual decoys of three types. To fabricate decoys of the first type, a polymer sheet coated with a Bragg-stack reflector was loosely stamped by a bioreplicating die. For decoys of the second type, a polymer sheet coated with a Bragg-stack reflector was heavily stamped by the same die and then painted green. Every decoy of these two types had an underlying black absorber layer. Decoys of the third type were produced by a rapid prototyping machine and painted green. Fine-scale features were absent on the third type. Experiments were performed in an American ash forest infested with EAB, and a European oak forest home to a similar pest, the two-spotted oak borer (TSOB), Agrilus biguttatus. When pinned to leaves, dead EAB females, dead TSOB females, and bioreplicated decoys of both types often evoked the complete ritualized flight behavior. Males also initiated approaches to the rapidly prototyped decoy, but would divert elsewhere without making contact. The attraction of the bioreplicated decoys was also demonstrated by providing a high dc voltage across the decoys that stunned and killed approaching beetles. Thus, true bioreplication with fine-scale features is necessary to fully evoke ritualized visual responses in insects, and provides an opportunity for developing insecttrapping technologies.

  5. Attacks exploiting deviation of mean photon number in quantum key distribution and coin tossing

    NASA Astrophysics Data System (ADS)

    Sajeed, Shihan; Radchenko, Igor; Kaiser, Sarah; Bourgoin, Jean-Philippe; Pappa, Anna; Monat, Laurent; Legré, Matthieu; Makarov, Vadim

    2015-03-01

    The security of quantum communication using a weak coherent source requires an accurate knowledge of the source's mean photon number. Finite calibration precision or an active manipulation by an attacker may cause the actual emitted photon number to deviate from the known value. We model effects of this deviation on the security of three quantum communication protocols: the Bennett-Brassard 1984 (BB84) quantum key distribution (QKD) protocol without decoy states, Scarani-Acín-Ribordy-Gisin 2004 (SARG04) QKD protocol, and a coin-tossing protocol. For QKD we model both a strong attack using technology possible in principle and a realistic attack bounded by today's technology. To maintain the mean photon number in two-way systems, such as plug-and-play and relativistic quantum cryptography schemes, bright pulse energy incoming from the communication channel must be monitored. Implementation of a monitoring detector has largely been ignored so far, except for ID Quantique's commercial QKD system Clavis2. We scrutinize this implementation for security problems and show that designing a hack-proof pulse-energy-measuring detector is far from trivial. Indeed, the first implementation has three serious flaws confirmed experimentally, each of which may be exploited in a cleverly constructed Trojan-horse attack. We discuss requirements for a loophole-free implementation of the monitoring detector.

  6. Gate Tuning of Förster Resonance Energy Transfer in a Graphene - Quantum Dot FET Photo-Detector

    PubMed Central

    Li, Ruifeng; Schneider, Lorenz Maximilian; Heimbrodt, Wolfram; Wu, Huizhen; Koch, Martin; Rahimi-Iman, Arash

    2016-01-01

    Graphene photo-detectors functionalized by colloidal quantum dots (cQDs) have been demonstrated to show effective photo-detection. Although the transfer of charge carriers or energy from the cQDs to graphene is not sufficiently understood, it is clear that the mechanism and efficiency of the transfer depends on the morphology of the interface between cQDs and graphene, which is determined by the shell of the cQDs in combination with its ligands. Here, we present a study of a graphene field-effect transistor (FET), which is functionalized by long-ligand CdSe/ZnS core/shell cQDs. Time-resolved photo-luminescence from the cQDs as a function of the applied gate voltage has been investigated in order to probe transfer dynamics in this system. Thereby, a clear modification of the photo-luminescence lifetime has been observed, indicating a change of the decay channels. Furthermore, we provide responsivities under a Förster-like energy transfer model as a function of the gate voltage in support of our findings. The model shows that by applying a back-gate voltage to the photo-detector, the absorption can be tuned with respect to the photo-luminescence of the cQDs. This leads to a tunable energy transfer rate across the interface of the photo-detector, which offers an opportunity to optimize the photo-detection. PMID:27320182

  7. Gate Tuning of Förster Resonance Energy Transfer in a Graphene - Quantum Dot FET Photo-Detector.

    PubMed

    Li, Ruifeng; Schneider, Lorenz Maximilian; Heimbrodt, Wolfram; Wu, Huizhen; Koch, Martin; Rahimi-Iman, Arash

    2016-01-01

    Graphene photo-detectors functionalized by colloidal quantum dots (cQDs) have been demonstrated to show effective photo-detection. Although the transfer of charge carriers or energy from the cQDs to graphene is not sufficiently understood, it is clear that the mechanism and efficiency of the transfer depends on the morphology of the interface between cQDs and graphene, which is determined by the shell of the cQDs in combination with its ligands. Here, we present a study of a graphene field-effect transistor (FET), which is functionalized by long-ligand CdSe/ZnS core/shell cQDs. Time-resolved photo-luminescence from the cQDs as a function of the applied gate voltage has been investigated in order to probe transfer dynamics in this system. Thereby, a clear modification of the photo-luminescence lifetime has been observed, indicating a change of the decay channels. Furthermore, we provide responsivities under a Förster-like energy transfer model as a function of the gate voltage in support of our findings. The model shows that by applying a back-gate voltage to the photo-detector, the absorption can be tuned with respect to the photo-luminescence of the cQDs. This leads to a tunable energy transfer rate across the interface of the photo-detector, which offers an opportunity to optimize the photo-detection.

  8. Gate Tuning of Förster Resonance Energy Transfer in a Graphene - Quantum Dot FET Photo-Detector

    NASA Astrophysics Data System (ADS)

    Li, Ruifeng; Schneider, Lorenz Maximilian; Heimbrodt, Wolfram; Wu, Huizhen; Koch, Martin; Rahimi-Iman, Arash

    2016-06-01

    Graphene photo-detectors functionalized by colloidal quantum dots (cQDs) have been demonstrated to show effective photo-detection. Although the transfer of charge carriers or energy from the cQDs to graphene is not sufficiently understood, it is clear that the mechanism and efficiency of the transfer depends on the morphology of the interface between cQDs and graphene, which is determined by the shell of the cQDs in combination with its ligands. Here, we present a study of a graphene field-effect transistor (FET), which is functionalized by long-ligand CdSe/ZnS core/shell cQDs. Time-resolved photo-luminescence from the cQDs as a function of the applied gate voltage has been investigated in order to probe transfer dynamics in this system. Thereby, a clear modification of the photo-luminescence lifetime has been observed, indicating a change of the decay channels. Furthermore, we provide responsivities under a Förster-like energy transfer model as a function of the gate voltage in support of our findings. The model shows that by applying a back-gate voltage to the photo-detector, the absorption can be tuned with respect to the photo-luminescence of the cQDs. This leads to a tunable energy transfer rate across the interface of the photo-detector, which offers an opportunity to optimize the photo-detection.

  9. Gate Tuning of Förster Resonance Energy Transfer in a Graphene - Quantum Dot FET Photo-Detector.

    PubMed

    Li, Ruifeng; Schneider, Lorenz Maximilian; Heimbrodt, Wolfram; Wu, Huizhen; Koch, Martin; Rahimi-Iman, Arash

    2016-01-01

    Graphene photo-detectors functionalized by colloidal quantum dots (cQDs) have been demonstrated to show effective photo-detection. Although the transfer of charge carriers or energy from the cQDs to graphene is not sufficiently understood, it is clear that the mechanism and efficiency of the transfer depends on the morphology of the interface between cQDs and graphene, which is determined by the shell of the cQDs in combination with its ligands. Here, we present a study of a graphene field-effect transistor (FET), which is functionalized by long-ligand CdSe/ZnS core/shell cQDs. Time-resolved photo-luminescence from the cQDs as a function of the applied gate voltage has been investigated in order to probe transfer dynamics in this system. Thereby, a clear modification of the photo-luminescence lifetime has been observed, indicating a change of the decay channels. Furthermore, we provide responsivities under a Förster-like energy transfer model as a function of the gate voltage in support of our findings. The model shows that by applying a back-gate voltage to the photo-detector, the absorption can be tuned with respect to the photo-luminescence of the cQDs. This leads to a tunable energy transfer rate across the interface of the photo-detector, which offers an opportunity to optimize the photo-detection. PMID:27320182

  10. Subversion of cytokine networks by virally encoded decoy receptors

    PubMed Central

    Epperson, Megan L.; Lee, Chung A.; Fremont, Daved H.

    2012-01-01

    Summary During the course of evolution, viruses have captured or created a diverse array of open reading frames that encode for proteins that serve to evade and sabotage the host innate and adaptive immune responses, which would otherwise lead to their elimination. These viral genomes are some of the best textbooks of immunology ever written. The established arsenal of immunomodulatory proteins encoded by viruses is large and growing and includes specificities for virtually all known inflammatory pathways and targets. The focus of this review is on herpes and poxvirus-encoded cytokine and chemokine binding proteins that serve to undermine the coordination of host immune surveillance. Structural and mechanistic studies of these decoy receptors have provided a wealth of information, not only about viral pathogenesis but also about the inner workings of cytokine signaling networks. PMID:23046131

  11. Towards Quantum Experiments with Human Eyes as Detectors Based on Cloning via Stimulated Emission

    NASA Astrophysics Data System (ADS)

    Sekatski, Pavel; Brunner, Nicolas; Branciard, Cyril; Gisin, Nicolas; Simon, Christoph

    2009-09-01

    We show theoretically that a large Bell inequality violation can be obtained with human eyes as detectors, in a “micro-macro” experiment where one photon from an entangled pair is greatly amplified via stimulated emission. The violation is robust under photon loss. This leads to an apparent paradox, which we resolve by noting that the violation proves the existence of entanglement before the amplification. The same is true for the micro-macro experiments performed so far with conventional detectors. However, we also prove that there is genuine micro-macro entanglement even for high loss.

  12. Nanostructured LaF{sub 3}:Ce Quantum Dot Nuclear Radiation Detector

    SciTech Connect

    Guss, P., Guise, R., Reed, M., Mukhopadhyay, S., Yuan, D.

    2010-11-01

    Many radioactive isotopes have low energy X-rays and high energy gamma rays of interest for detection. The goal of the work presented was to demonstrate the possibility of measuring both low-energy X-rays and relatively high-energy gamma rays simultaneously using the nano-structured lanthanum bromide, lanthanum fluoride, or cerium bromide. The key accomplishments of the project was the building and acquisition of the LaF3:Ce nanocomposite detectors. Nanocomposite detectors are sensitive to {gamma}’s as well as n’s and X-rays.

  13. The quantum limit for gravitational-wave detectors and methods of circumventing it

    NASA Technical Reports Server (NTRS)

    Thorne, K. S.; Caves, C. M.; Sandberg, V. D.; Zimmermann, M.; Drever, R. W. P.

    1979-01-01

    The Heisenberg uncertainty principle prevents the monitoring of the complex amplitude of a mechanical oscillator more accurately than a certain limit value. This 'quantum limit' is a serious obstacle to the achievement of a 10 to the -21st gravitational-wave detection sensitivity. This paper examines the principles of the back-action evasion technique and finds that this technique may be able to overcome the problem of the quantum limit. Back-action evasion does not solve, however, other problems of detection, such as weak coupling, large amplifier noise, and large Nyquist noise.

  14. NFkappaB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts.

    PubMed

    Shimizu, H; Nakagami, H; Tsukamoto, I; Morita, S; Kunugiza, Y; Tomita, T; Yoshikawa, H; Kaneda, Y; Ogihara, T; Morishita, R

    2006-06-01

    The transcription factor, nuclear factor-kappa B (NFkappaB), is believed to play a pivotal role in osteoclast formation. In this study, we focused on NFkappaB decoy oligodeoxynucleotides (ODN) as a new therapeutic strategy to attenuate osteoporosis. Tartrate-resistant acid phosphatase (TRAP)-positive multinuclear osteoclasts formed in mononuclear cells including osteoclast precursors from neonatal rabbit bone marrow were increased in the presence of 1,25-dihydroxyvitamin D3, whereas transfection of NFkappaB decoy ODN decreased the number of TRAP-positive cells and attenuated RANKL and M-CSF-induced osteoclast formation. NFkappaB decoy ODN also inhibited the activity of osteoclasts, as assessed by pit formation. In rat ovariectomized model of estrogen deficiency, continuous administration of NFkappaB decoy ODN attenuated the increase of TRAP activity, accompanied by a significant increase in calcium concentration in tibia and femur and decrease in urinary deoxypyridinoline. In additional osteoporosis model using vitamin C-deficient rat, inhibition of NFkappaB by decoy ODN dramatically improved the bone length, weight, density as assessed by dual-energy X-ray absorptiometry. Overall, inhibition of NFkappaB by decoy strategy prevented osteoporosis through the inhibition of bone resorption. Targeting of NFkappaB might be potential therapy in various bone metabolic diseases.

  15. The development of the asymmetrically dominated decoy effect in young children

    PubMed Central

    Zhen, Shanshan; Yu, Rongjun

    2016-01-01

    One classic example of context-independent violations is the asymmetrically dominated decoy effect, in which adding a decoy option (inferior option) to a set of original options often increases the individual’s preference for one option over the other original option. Despite the prevalence of this effect, little is known about its developmental origins. Moreover, it remains contentious whether the decoy effect is a result of biological evolution or is learned from social experience. Here, we investigated the decoy effect in 3- to 7-year-old children (n = 175) and young adults (n = 52) using a simple perceptual task. Results showed that older children (5-year-olds and 7-year-olds), but not younger children (3-year-olds), exhibited a decoy effect. Nevertheless, children as young as age 5 exhibited a decoy effect that was not significantly different from that shown by young adults. These findings suggest that humans start to appreciate the relative values of options at around age 5. PMID:26935899

  16. Artificial decoy spectral libraries for false discovery rate estimation in spectral library searching in proteomics.

    PubMed

    Lam, Henry; Deutsch, Eric W; Aebersold, Ruedi

    2010-01-01

    The challenge of estimating false discovery rates (FDR) in peptide identification from MS/MS spectra has received increased attention in proteomics. The simple approach of target-decoy searching has become popular with traditional sequence (database) searching methods, but has yet to be practiced in spectral (library) searching, an emerging alternative to sequence searching. We extended this target-decoy searching approach to spectral searching by developing and validating a robust method to generate realistic, but unnatural, decoy spectra. Our method involves randomly shuffling the peptide identification of each reference spectrum in the library, and repositioning each fragment ion peak along the m/z axis to match the fragment ions expected from the shuffled sequence. We show that this method produces decoy spectra that are sufficiently realistic, such that incorrect identifications are equally likely to match real and decoy spectra, a key assumption necessary for decoy counting. This approach has been implemented in the open-source library building software, SpectraST.

  17. Intrinsic imperfection of self-differencing single-photon detectors harms the security of high-speed quantum cryptography systems

    NASA Astrophysics Data System (ADS)

    Jiang, Mu-Sheng; Sun, Shi-Hai; Tang, Guang-Zhao; Ma, Xiang-Chun; Li, Chun-Yan; Liang, Lin-Mei

    2013-12-01

    Thanks to the high-speed self-differencing single-photon detector (SD-SPD), the secret key rate of quantum key distribution (QKD), which can, in principle, offer unconditionally secure private communications between two users (Alice and Bob), can exceed 1 Mbit/s. However, the SD-SPD may contain loopholes, which can be exploited by an eavesdropper (Eve) to hack into the unconditional security of the high-speed QKD systems. In this paper, we analyze the fact that the SD-SPD can be remotely controlled by Eve in order to spy on full information without being discovered, then proof-of-principle experiments are demonstrated. Here, we point out that this loophole is introduced directly by the operating principle of the SD-SPD, thus, it cannot be removed, except for the fact that some active countermeasures are applied by the legitimate parties.

  18. Photocurrent spectrum study of a quantum dot single-photon detector based on resonant tunneling effect with near-infrared response

    SciTech Connect

    Weng, Q. C.; An, Z. H. E-mail: luwei@mail.sitp.ac.cn; Xiong, D. Y.; Zhu, Z. Q.; Zhang, B.; Chen, P. P.; Li, T. X.; Lu, W. E-mail: luwei@mail.sitp.ac.cn

    2014-07-21

    We present the photocurrent spectrum study of a quantum dot (QD) single-photon detector using a reset technique which eliminates the QD's “memory effect.” By applying a proper reset frequency and keeping the detector in linear-response region, the detector's responses to different monochromatic light are resolved which reflects different detection efficiencies. We find the reset photocurrent tails up to 1.3 μm wavelength and near-infrared (∼1100 nm) single-photon sensitivity is demonstrated due to interband transition of electrons in QDs, indicating the device a promising candidate both in quantum information applications and highly sensitive imaging applications operating in relative high temperatures (>80 K).

  19. Decoy plasminogen receptor containing a selective Kunitz-inhibitory domain.

    PubMed

    Kumar, Yogesh; Vadivel, Kanagasabai; Schmidt, Amy E; Ogueli, Godwin I; Ponnuraj, Sathya M; Rannulu, Nalaka; Loo, Joseph A; Bajaj, Madhu S; Bajaj, S Paul

    2014-01-28

    Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in which P2' residue Leu17 (bovine pancreatic trypsin inhibitor numbering) is mutated to Arg selectively inhibits the active site of plasmin with ∼5-fold improved affinity. Thrombin cleavage (24 h extended incubation at a 1:50 enzyme-to-substrate ratio) of the KD1 mutant (Leu17Arg) yielded a smaller molecule containing the intact Kunitz domain with no detectable change in the active-site inhibitory function. The N-terminal sequencing and MALDI-TOF/ESI data revealed that the starting molecule has a C-terminal valine (KD1L17R-VT), whereas the smaller molecule has a C-terminal lysine (KD1L17R-KT). Because KD1L17R-KT has C-terminal lysine, we examined whether it could serve as a decoy receptor for plasminogen/plasmin. Such a molecule might inhibit plasminogen activation as well as the active site of generated plasmin. In surface plasmon resonance experiments, tissue plasminogen activator (tPA) and Glu-plasminogen bound to KD1L17R-KT (Kd ∼ 0.2 to 0.3 μM) but not to KD1L17R-VT. Furthermore, KD1L17R-KT inhibited tPA-induced plasma clot fibrinolysis more efficiently than KD1L17R-VT. Additionally, compared to ε-aminocaproic acid KD1L17R-KT was more effective in reducing blood loss in a mouse liver-laceration injury model, where the fibrinolytic system is activated. In further experiments, the micro(μ)-plasmin-KD1L17R-KT complex inhibited urokinase-induced plasminogen activation on phorbol-12-myristate-13-acetate-stimulated U937 monocyte-like cells, whereas the μ-plasmin-KD1L17R-VT complex failed to inhibit this process. In conclusion, KD1L17R-KT inhibits the active site of plasmin as well as acts as a decoy receptor for the kringle domain(s) of plasminogen/plasmin; hence, it limits both plasmin generation and activity. With its dual function, KD1L17R-KT could serve as a preferred agent for controlling plasminogen activation in pathological processes. PMID:24383758

  20. Using decoy effects to influence an online brand choice: the role of price-quality trade-offs.

    PubMed

    Hsu, Huei-Chen; Liu, Wen-Liang

    2011-04-01

    This research aims to investigate decoy effects on online brand choices. To assess the influence of decoys, we test decoy effects on three constructs-product involvement, judgment conditions, and decoy conditions-within an online experiment. A survey of 635 Internet users and a 2 × 2 × 3 ANOVA between-subjects experimental design is used to guide the research design and the systematic analysis procedure. A major finding of this study is that a standard decoy seems to have a significant effect on an advertised (target) brand for high-involvement products; from the survey, it is also apparent that competitors can also use inferior decoys to increase brand preference for low-involvement products.

  1. A Medipix quantum area detector allows rotation electron diffraction data collection from submicrometre three-dimensional protein crystals

    SciTech Connect

    Nederlof, Igor; Genderen, Eric van; Li, Yao-Wang; Abrahams, Jan Pieter

    2013-07-01

    An ultrasensitive Medipix2 detector allowed the collection of rotation electron-diffraction data from single three-dimensional protein nanocrystals for the first time. The data could be analysed using the standard X-ray crystallography programs MOSFLM and SCALA. When protein crystals are submicrometre-sized, X-ray radiation damage precludes conventional diffraction data collection. For crystals that are of the order of 100 nm in size, at best only single-shot diffraction patterns can be collected and rotation data collection has not been possible, irrespective of the diffraction technique used. Here, it is shown that at a very low electron dose (at most 0.1 e{sup −} Å{sup −2}), a Medipix2 quantum area detector is sufficiently sensitive to allow the collection of a 30-frame rotation series of 200 keV electron-diffraction data from a single ∼100 nm thick protein crystal. A highly parallel 200 keV electron beam (λ = 0.025 Å) allowed observation of the curvature of the Ewald sphere at low resolution, indicating a combined mosaic spread/beam divergence of at most 0.4°. This result shows that volumes of crystal with low mosaicity can be pinpointed in electron diffraction. It is also shown that strategies and data-analysis software (MOSFLM and SCALA) from X-ray protein crystallography can be used in principle for analysing electron-diffraction data from three-dimensional nanocrystals of proteins.

  2. High quantum efficiency and low dark count rate in multi-layer superconducting nanowire single-photon detectors

    SciTech Connect

    Jafari Salim, A. Eftekharian, A.; Hamed Majedi, A.

    2014-02-07

    In this paper, we theoretically show that a multi-layer superconducting nanowire single-photon detector (SNSPD) is capable of approaching characteristics of an ideal SNSPD in terms of the quantum efficiency, dark count, and band-width. A multi-layer structure improves the performance in two ways. First, the potential barrier for thermally activated vortex crossing, which is the major source of dark counts and the reduction of the critical current in SNSPDs is elevated. In a multi-layer SNSPD, a vortex is made of 2D-pancake vortices that form a stack. It will be shown that the stack of pancake vortices effectively experiences a larger potential barrier compared to a vortex in a single-layer SNSPD. This leads to an increase in the experimental critical current as well as significant decrease in the dark count rate. In consequence, an increase in the quantum efficiency for photons of the same energy or an increase in the sensitivity to photons of lower energy is achieved. Second, a multi-layer structure improves the efficiency of single-photon absorption by increasing the effective optical thickness without compromising the single-photon sensitivity.

  3. [Research on Spectrum Radiation Characteristics of a New Type Infrared/ Ultraviolet Dual Color Decoy].

    PubMed

    Chen, Chun-sheng; Dai, Meng-yan; Liu, Hai-feng; Xie, Chang-you; Zhang, Tong; Fang, Guo-feng

    2015-07-01

    The advantage of traditional MTV infrared decoys which are mainly consist of magnesium, Teflon and VITON is that it emits high radiant energy, so it is an effective countermeasure to traditional seekers which seek the target by heat source. The spectral radiant intensity which generated from high temperature combustion of MTV infrared decoys in near infrared region and ultraviolet band is very high, and that in Mid-IR region is relative lower, however the radiant intensity of real jet fighter in ultraviolet band is low and the infrared radiant intensity ratio of Mid-IR to near IR band is greater than 1. Thus, the traditional MTV infrared decoys are hardly able to counter the seekers equipped with dual color combined guidance system. Based on the spectral matching principle, we designed and prepared a new infrared/ultraviolet dual color decoy which is mainly consist of oxidant (wt% 45-75), fuel (wt% 10-25), energetic binder (wt% 25-50) and additives. We conducted theoretical calculations on combustion products of the reagent combinations using CEA (Chemic equilibrium & Application) software and initially determined the content of each component of the decoy formulation on the basis of the calculations results, then investigated the infrared radiation characteristics of decoys employing SR5000 spectrum radiometer and remote sensing interferometer spectrometer Tensor37 and analyzed the possible reasons for test results difference of the two systems separately from the test principle and calculation method, the testing environment, stability of testing results and other aspects. We studied the ultraviolet radiation characteristics of decoys using S2000 fiber optical spectrometer and the test results were consistent with the fighter ultraviolet radiant intensity which gained from theoretical calculation. We researched on the temperature characteristics of decoys by Imager IR 8325 mid-infrared thermal imager and it turned out that the dual color decoy is similar to the

  4. [Research on Spectrum Radiation Characteristics of a New Type Infrared/ Ultraviolet Dual Color Decoy].

    PubMed

    Chen, Chun-sheng; Dai, Meng-yan; Liu, Hai-feng; Xie, Chang-you; Zhang, Tong; Fang, Guo-feng

    2015-07-01

    The advantage of traditional MTV infrared decoys which are mainly consist of magnesium, Teflon and VITON is that it emits high radiant energy, so it is an effective countermeasure to traditional seekers which seek the target by heat source. The spectral radiant intensity which generated from high temperature combustion of MTV infrared decoys in near infrared region and ultraviolet band is very high, and that in Mid-IR region is relative lower, however the radiant intensity of real jet fighter in ultraviolet band is low and the infrared radiant intensity ratio of Mid-IR to near IR band is greater than 1. Thus, the traditional MTV infrared decoys are hardly able to counter the seekers equipped with dual color combined guidance system. Based on the spectral matching principle, we designed and prepared a new infrared/ultraviolet dual color decoy which is mainly consist of oxidant (wt% 45-75), fuel (wt% 10-25), energetic binder (wt% 25-50) and additives. We conducted theoretical calculations on combustion products of the reagent combinations using CEA (Chemic equilibrium & Application) software and initially determined the content of each component of the decoy formulation on the basis of the calculations results, then investigated the infrared radiation characteristics of decoys employing SR5000 spectrum radiometer and remote sensing interferometer spectrometer Tensor37 and analyzed the possible reasons for test results difference of the two systems separately from the test principle and calculation method, the testing environment, stability of testing results and other aspects. We studied the ultraviolet radiation characteristics of decoys using S2000 fiber optical spectrometer and the test results were consistent with the fighter ultraviolet radiant intensity which gained from theoretical calculation. We researched on the temperature characteristics of decoys by Imager IR 8325 mid-infrared thermal imager and it turned out that the dual color decoy is similar to the

  5. Fabrication of multi-layered absorption structure for high quantum efficiency photon detectors

    SciTech Connect

    Fujii, Go; Fukuda, Daiji; Numata, Takayuki; Yoshizawa, Akio; Tsuchida, Hidemi; Fujino, Hidetoshi; Ishii, Hiroyuki; Itatani, Taro; Zama, Tatsuya; Inoue, Shuichiro

    2009-12-16

    We report on some efforts to improve a quantum efficiency of titanium-based optical superconducting transition edge sensors using the multi-layered absorption structure for maximizing photon absorption in the Ti layer. Using complex refractive index values of each film measured by a Spectroscopic Ellipsometry, we designed and optimized by a simulation code. An absorption measurement of fabricated structure was in good agreement with the design and was higher than 99% at optimized wavelength of 1550 nm.

  6. MANPADS protection for civil aircraft using an expendable decoy

    NASA Astrophysics Data System (ADS)

    Walmsley, Roy H.; Friede, Johan; Millwood, Nicolas; Butters, Brian

    2009-09-01

    With the ever present threat of MANPADS throughout the world the protection of civil aircraft is a desirable capability that has special requirements in terms of certification, safety, logistics, affordability, environmental impact and exportability. The Civil Aircraft Missile Protection System (CAMPS), which includes the CIV-IR (infrared) leaf-based pyrophoric (not pyrotechnic) expendable countermeasure, is a system designed to meet these requirements. This paper presents the operating aspects of the decoy, including discussion of design features necessary to ensure safety both on the ground and in flight and assure successful deployment. The characteristics of the CIV-IR have been measured, both on static single leaves in the laboratory and on deployed packs in field tests and aircraft trials. These measured properties have been used in engagement modelling and simulation to assess the level of protection that can be afforded to commercial airliners against generation 1 and 2 MANPADS threats. Aircraft flight trials with ground based seekers have also been carried out to validate the modelling work. These combine to define the deployment patterns necessary for a successful seduction of the MANPAD.

  7. Scalable quantum information processing with photons and atoms

    NASA Astrophysics Data System (ADS)

    Pan, Jian-Wei

    Over the past three decades, the promises of super-fast quantum computing and secure quantum cryptography have spurred a world-wide interest in quantum information, generating fascinating quantum technologies for coherent manipulation of individual quantum systems. However, the distance of fiber-based quantum communications is limited due to intrinsic fiber loss and decreasing of entanglement quality. Moreover, probabilistic single-photon source and entanglement source demand exponentially increased overheads for scalable quantum information processing. To overcome these problems, we are taking two paths in parallel: quantum repeaters and through satellite. We used the decoy-state QKD protocol to close the loophole of imperfect photon source, and used the measurement-device-independent QKD protocol to close the loophole of imperfect photon detectors--two main loopholes in quantum cryptograph. Based on these techniques, we are now building world's biggest quantum secure communication backbone, from Beijing to Shanghai, with a distance exceeding 2000 km. Meanwhile, we are developing practically useful quantum repeaters that combine entanglement swapping, entanglement purification, and quantum memory for the ultra-long distance quantum communication. The second line is satellite-based global quantum communication, taking advantage of the negligible photon loss and decoherence in the atmosphere. We realized teleportation and entanglement distribution over 100 km, and later on a rapidly moving platform. We are also making efforts toward the generation of multiphoton entanglement and its use in teleportation of multiple properties of a single quantum particle, topological error correction, quantum algorithms for solving systems of linear equations and machine learning. Finally, I will talk about our recent experiments on quantum simulations on ultracold atoms. On the one hand, by applying an optical Raman lattice technique, we realized a two-dimensional spin-obit (SO

  8. Bioreplicated visual features of nanofabricated buprestid beetle decoys evoke stereotypical male mating flights.

    PubMed

    Domingue, Michael J; Lakhtakia, Akhlesh; Pulsifer, Drew P; Hall, Loyal P; Badding, John V; Bischof, Jesse L; Martín-Palma, Raúl J; Imrei, Zoltán; Janik, Gergely; Mastro, Victor C; Hazen, Missy; Baker, Thomas C

    2014-09-30

    Recent advances in nanoscale bioreplication processes present the potential for novel basic and applied research into organismal behavioral processes. Insect behavior potentially could be affected by physical features existing at the nanoscale level. We used nano-bioreplicated visual decoys of female emerald ash borer beetles (Agrilus planipennis) to evoke stereotypical mate-finding behavior, whereby males fly to and alight on the decoys as they would on real females. Using an industrially scalable nanomolding process, we replicated and evaluated the importance of two features of the outer cuticular surface of the beetle's wings: structural interference coloration of the elytra by multilayering of the epicuticle and fine-scale surface features consisting of spicules and spines that scatter light into intense strands. Two types of decoys that lacked one or both of these elements were fabricated, one type nano-bioreplicated and the other 3D-printed with no bioreplicated surface nanostructural elements. Both types were colored with green paint. The light-scattering properties of the nano-bioreplicated surfaces were verified by shining a white laser on the decoys in a dark room and projecting the scattering pattern onto a white surface. Regardless of the coloration mechanism, the nano-bioreplicated decoys evoked the complete attraction and landing sequence of Agrilus males. In contrast, males made brief flying approaches toward the decoys without nanostructured features, but diverted away before alighting on them. The nano-bioreplicated decoys were also electroconductive, a feature used on traps such that beetles alighting onto them were stunned, killed, and collected. PMID:25225359

  9. Bioreplicated visual features of nanofabricated buprestid beetle decoys evoke stereotypical male mating flights

    PubMed Central

    Domingue, Michael J.; Lakhtakia, Akhlesh; Pulsifer, Drew P.; Hall, Loyal P.; Badding, John V.; Bischof, Jesse L.; Martín-Palma, Raúl J.; Imrei, Zoltán; Janik, Gergely; Mastro, Victor C.; Hazen, Missy; Baker, Thomas C.

    2014-01-01

    Recent advances in nanoscale bioreplication processes present the potential for novel basic and applied research into organismal behavioral processes. Insect behavior potentially could be affected by physical features existing at the nanoscale level. We used nano-bioreplicated visual decoys of female emerald ash borer beetles (Agrilus planipennis) to evoke stereotypical mate-finding behavior, whereby males fly to and alight on the decoys as they would on real females. Using an industrially scalable nanomolding process, we replicated and evaluated the importance of two features of the outer cuticular surface of the beetle’s wings: structural interference coloration of the elytra by multilayering of the epicuticle and fine-scale surface features consisting of spicules and spines that scatter light into intense strands. Two types of decoys that lacked one or both of these elements were fabricated, one type nano-bioreplicated and the other 3D-printed with no bioreplicated surface nanostructural elements. Both types were colored with green paint. The light-scattering properties of the nano-bioreplicated surfaces were verified by shining a white laser on the decoys in a dark room and projecting the scattering pattern onto a white surface. Regardless of the coloration mechanism, the nano-bioreplicated decoys evoked the complete attraction and landing sequence of Agrilus males. In contrast, males made brief flying approaches toward the decoys without nanostructured features, but diverted away before alighting on them. The nano-bioreplicated decoys were also electroconductive, a feature used on traps such that beetles alighting onto them were stunned, killed, and collected. PMID:25225359

  10. Optical communication with two-photon coherent states. III - Quantum measurements realizable with photoemissive detectors

    NASA Technical Reports Server (NTRS)

    Yuen, H. P.; Shapiro, J. H.

    1980-01-01

    Homodyne detection is shown to achieve the same signal-to-noise ratio as the quantum field quadrature measurement, thus providing a receiver which realizes linear modulation TCS performance gain. The full equivalence of homodyne detection and single-quadrature field measurement is established. A heterodyne configuration which uses a TCS image-band oscillator in addition to the usual coherent state local oscillator is studied. Results are obtained by means of a representation theorem which shows that photoemissive detection realizes the photon flux density measurement.

  11. Triangular-barrier quantum rod photodiodes: Their fabrication and detector characteristics

    SciTech Connect

    Ohmori, M.; Kobayashi, Y.; Vitushinskiy, P.; Nakamura, S.; Kojima, T.; Sakaki, H.

    2014-02-24

    We have fabricated a GaAs-based triangular-barrier photodiode, in which self-assembled InGaAs quantum rods (Q-rods) are embedded in its barrier region. Transport study at 100 K has shown that electrons start to flow mainly through Q-rods when a bias is set above a threshold. Upon illumination, photo-generated holes are found to accumulate in the middle portion of Q-rods and efficiently lower the local barrier height, yielding the responsivity as high as 10{sup 5} A/W at the incident light of 1 fW.

  12. Optical logic using electrically connected quantum well PIN diode modulators and detectors.

    PubMed

    Lentine, A L; Miller, D A; Henry, J E; Cunningham, J E; Chirovsky, L M; D'Asaro, L A

    1990-05-10

    We present new optoelectronic logic devices or circuits consisting of electrically connected quantum well PIN diodes capable of implementing any boolean logic function. One class of circuits uses single beams to represent the logic levels and compares their intensities to a locally generated reference signal. A second class of circuits routes signals as differential pairs. The connections of diodes in these circuits resemble the transistor connections in NMOS and CMOS logic families. We demonstrate simple optical programmable logic arrays (e.g., E = AB + CD) using both of these classes of circuits. PMID:20563144

  13. Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction

    PubMed Central

    Klaus, Miriam; Prokoph, Nina; Girbig, Mathias; Wang, Xuecong; Huang, Yong-Heng; Srivastava, Yogesh; Hou, Linlin; Narasimhan, Kamesh; Kolatkar, Prasanna R.; Francois, Mathias; Jauch, Ralf

    2016-01-01

    The transcription factor (TF) SOX18 drives lymphatic vessel development in both embryogenesis and tumour-induced neo-lymphangiogenesis. Genetic disruption of Sox18 in a mouse model protects from tumour metastasis and established the SOX18 protein as a molecular target. Here, we report the crystal structure of the SOX18 DNA binding high-mobility group (HMG) box bound to a DNA element regulating Prox1 transcription. The crystals diffracted to 1.75Å presenting the highest resolution structure of a SOX/DNA complex presently available revealing water structure, structural adjustments at the DNA contact interface and non-canonical conformations of the DNA backbone. To explore alternatives to challenging small molecule approaches for targeting the DNA-binding activity of SOX18, we designed a set of five decoys based on modified Prox1-DNA. Four decoys potently inhibited DNA binding of SOX18 in vitro and did not interact with non-SOX TFs. Serum stability, nuclease resistance and thermal denaturation assays demonstrated that a decoy circularized with a hexaethylene glycol linker and terminal phosphorothioate modifications is most stable. This SOX decoy also interfered with the expression of a luciferase reporter under control of a SOX18-dependent VCAM1 promoter in COS7 cells. Collectively, we propose SOX decoys as potential strategy for inhibiting SOX18 activity to disrupt tumour-induced neo-lymphangiogenesis. PMID:26939885

  14. High Throughput, High Yield Fabrication of High Quantum Efficiency Back-Illuminated Photon Counting, Far UV, UV, and Visible Detector Arrays

    NASA Technical Reports Server (NTRS)

    Nikzad, Shouleh; Hoenk, M. E.; Carver, A. G.; Jones, T. J.; Greer, F.; Hamden, E.; Goodsall, T.

    2013-01-01

    In this paper we discuss the high throughput end-to-end post fabrication processing of high performance delta-doped and superlattice-doped silicon imagers for UV, visible, and NIR applications. As an example, we present our results on far ultraviolet and ultraviolet quantum efficiency (QE) in a photon counting, detector array. We have improved the QE by nearly an order of magnitude over microchannel plates (MCPs) that are the state-of-the-art UV detectors for many NASA space missions as well as defense applications. These achievements are made possible by precision interface band engineering of Molecular Beam Epitaxy (MBE) and Atomic Layer Deposition (ALD).

  15. Photon detectors with high quantum efficiency at NUV range using a confinement of wavelength-shifted signals and optical couplers

    NASA Astrophysics Data System (ADS)

    Takahashi, Y.; Hadaway, J.; Pakhomov, A.; Takizawa, Y.

    Near-UV wavelengths 300 - 400 nm have been in a death-valley for photon detectors due to very low quantum efficiencies QE in this range Conventional bi-alkali photocathodes of PMTs do not have QE better than 20-26 Much better photo-cathodes like GaAsP GaN and similar give better efficiencies but only at wavelengths 400nm and are severely plagued by very short lifetimes Avalanche Photo-diodes perform better at low temperatures but no better than 35 QE in the NUV region Silicon Photo-multipliers at Geiger mode SiPM with micro-pixels have high QEs 90 like CCD and CMOS as bare silicon but are severely plagued by very poor geometrical fill-factors 30 and their overallQMis limited to no better than 20 at NUV regime An optical interference-filter works as a half-mirror passing more than 90 of NUV lights 300-400 nm and reflect more than 90 of longer wavelength lights 400 nm UV photons after converted into blue-green lights by wavelength-shifter are reflected back and confined without much loss back into space A specific dichroic interference mirror with WLS was made by RIKEN Japan H Shimizu Y Takahashi Y Takizawa Patent pending 2000-399940 for this optical principle It also allows a better use of limited photo-sensitive micro-cells of SiPM overcoming the past serious problem of its very poor fill-factor As a result Half-mirror SiPM yields high final efficiency for NUV photons This new detector TRAPPER with optical couplers for SiPM or by GaAsP PMTs could be used for photon-hungry space experiments at NUV range TRAPPER

  16. Cascaded-systems analyses and the detective quantum efficiency of single-Z x-ray detectors including photoelectric, coherent and incoherent interactions

    SciTech Connect

    Yun, Seungman; Tanguay, Jesse; Cunningham, Ian A.; Kim, Ho Kyung

    2013-04-15

    Purpose: Theoretical models of the detective quantum efficiency (DQE) of x-ray detectors are an important step in new detector development by providing an understanding of performance limitations and benchmarks. Previous cascaded-systems analysis (CSA) models accounted for photoelectric interactions only. This paper describes an extension of the CSA approach to incorporate coherent and incoherent interactions, important for low-Z detectors such as silicon and selenium. Methods: A parallel-cascade approach is used to describe the three types of x-ray interactions. The description of incoherent scatter required developing expressions for signal and noise transfer through an 'energy-labeled reabsorption' process where the parameters describing reabsorption are random functions of the scatter photon energy. The description of coherent scatter requires the use of scatter form factors that may not be accurate for some crystalline detector materials. The model includes the effects of scatter reabsorption and escape, charge collection, secondary quantum sinks, noise aliasing, and additive noise. Model results are validated by Monte Carlo calculations for Si and Se detectors assuming free-atom atomic form factors. Results: The new signal and noise transfer expressions were validated by showing agreement with Monte Carlo results. Coherent and incoherent scatter can degrade the DQE of Si and sometimes Se detectors depending on detector thickness and incident-photon energy. Incoherent scatter can produce a substantial low-frequency drop in the modulation transfer function and DQE. Conclusions: A generally useful CSA model of the DQE is described that is believed valid for any single-Z material up to 10 cycles/mm at both mammographic and radiographic energies within the limitations of Fourier-based linear-systems models and the use of coherent-scatter form factors. The model describes a substantial low-frequency drop in the DQE of Si systems due to incoherent scatter above 20

  17. When target-decoy false discovery rate estimations are inaccurate and how to spot instances.

    PubMed

    Chalkley, Robert J

    2013-02-01

    To address problems with estimating the reliability of proteomic search engine results from mass spectrometry fragmentation data, the use of target-decoy database searching has become the de facto approach for estimating a false discovery rate. Several articles have been written about the effects of different ways of creating the decoy database, effects of the search engine scoring, or effects of search parameters on whether this approach provides an accurate estimate, not all agreeing with each other's conclusions. Hence, there may be some confusion about how effective this approach is and how broadly it can be applied. Although it is generally very effective, in this article I will try to emphasize some of the pitfalls and dangers of using the target-decoy approach and will indicate tell-tale signs that something may be amiss. This information will hopefully help researchers become more astute in their assessment of search results.

  18. An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

    SciTech Connect

    Kariolis, Mihalis S.; Miao, Yu Rebecca; Jones, Douglas S.; Kapur, Shiven; Mathews, Irimpan I.; Giaccia, Amato J.; Cochran, Jennifer R.

    2014-09-21

    Aberrant signaling through the Axl receptor tyrosine kinase has been associated with a myriad of human diseases, most notably metastatic cancer, identifying Axl and its ligand Gas6 as important therapeutic targets. Using rational and combinatorial approaches, we engineered an Axl ‘decoy receptor’ that binds Gas6 with high affinity and inhibits its function, offering an alternative approach from drug discovery efforts that directly target Axl. Four mutations within this high affinity Axl variant caused structural alterations in side chains across the Gas6/Axl binding interface, stabilizing a conformational change on Gas6. When reformatted as an Fc-fusion, the engineered decoy receptor bound to Gas6 with femtomolar affinity, an 80-fold improvement compared to the wild-type Axl receptor, allowing effective sequestration of Gas6 and specific abrogation of Axl signaling. Additionally, increased Gas6 binding affinity was critical and correlative with the ability of decoy receptors to potently inhibit metastasis and disease progression in vivo.

  19. A long-distance quantum key distribution scheme based on pre-detection of optical pulse with auxiliary state

    NASA Astrophysics Data System (ADS)

    Quan, Dong-Xiao; Zhu, Chang-Hua; Liu, Shi-Quan; Pei, Chang-Xing

    2015-05-01

    We construct a circuit based on PBS and CNOT gates, which can be used to determine whether the input pulse is empty or not according to the detection result of the auxiliary state, while the input state will not be changed. The circuit can be treated as a pre-detection device. Equipping the pre-detection device in the front of the receiver of the quantum key distribution (QKD) can reduce the influence of the dark count of the detector, hence increasing the secure communication distance significantly. Simulation results show that the secure communication distance can reach 516 km and 479 km for QKD with perfect single photon source and decoy-state QKD with weak coherent photon source, respectively. Project supported by the National Natural Science Foundation of China (Grant No. 61372076), the Programme of Introducing Talents of Discipline to Universities, China (Grant No. B08038), and the Fundamental Research Funds for the Central Universities, China (Grant No. K5051201021).

  20. The problem with peptide presumption and the downfall of target-decoy false discovery rates

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In proteomics, peptide-tandem mass spectrum match scores and target-decoy database derived false discovery rates (FDR) are confidence indicators describing the quality of individual and sets of tandem mass spectrum matches. A user can impose a standard by prescribing a limit to these values, equival...

  1. Genetic diversity and antimicrobial resistance of Campylobacter and Salmonella strains isolated from decoys and raptors.

    PubMed

    Jurado-Tarifa, E; Torralbo, A; Borge, C; Cerdà-Cuéllar, M; Ayats, T; Carbonero, A; García-Bocanegra, I

    2016-10-01

    Infections caused by thermotolerant Campylobacter spp. and Salmonella spp. are the leading causes of human gastroenteritis worldwide. Wild birds can act as reservoirs of both pathogens. A survey was carried out to determine the prevalence, genetic diversity and antimicrobial resistance of thermotolerant Campylobacter and Salmonella in waterfowl used as decoys and wild raptors in Andalusia (Southern Spain). The overall prevalence detected for Campylobacter was 5.9% (18/306; CI95%: 3.25-8.52) in decoys and 2.3% (9/387; CI95%: 0.82-3.83) in wild raptors. Isolates were identified as C. jejuni, C. coli and C. lari in both bird groups. Salmonella was isolated in 3.3% (10/306; CI95%: 2.3-4.3) and 4.6% (18/394; CI95%: 3.5-5.6) of the decoys and raptors, respectively. Salmonella Enteritidis and Typhimurium were the most frequently identified serovars, although Salmonella serovars Anatum, Bredeney, London and Mikawasima were also isolated. Pulsed-field gel electrophoresis analysis of isolates showed higher genetic diversity within Campylobacter species compared to Salmonella serovars. Campylobacter isolates showed resistance to gentamicin, ciprofloxacin and tetracycline, while resistance to erythromycin and tetracycline was found in Salmonella isolates. The results indicate that both decoys and raptors can act as natural carriers of Campylobacter and Salmonella in Spain, which may have important implications for public and animal health. PMID:27638115

  2. Refining similarity scoring to enable decoy-free validation in spectral library searching.

    PubMed

    Shao, Wenguang; Zhu, Kan; Lam, Henry

    2013-11-01

    Spectral library searching is a maturing approach for peptide identification from MS/MS, offering an alternative to traditional sequence database searching. Spectral library searching relies on direct spectrum-to-spectrum matching between the query data and the spectral library, which affords better discrimination of true and false matches, leading to improved sensitivity. However, due to the inherent diversity of the peak location and intensity profiles of real spectra, the resulting similarity score distributions often take on unpredictable shapes. This makes it difficult to model the scores of the false matches accurately, necessitating the use of decoy searching to sample the score distribution of the false matches. Here, we refined the similarity scoring in spectral library searching to enable the validation of spectral search results without the use of decoys. We rank-transformed the peak intensities to standardize all spectra, making it possible to fit a parametric distribution to the scores of the nontop-scoring spectral matches. The statistical significance of the top-scoring match can then be estimated in a rigorous manner according to Extreme Value Theory. The overall result is a more robust and interpretable measure of the quality of the spectral match, which can be obtained without decoys. We tested this refined similarity scoring function on real datasets and demonstrated its effectiveness. This approach reduces search time, increases sensitivity, and extends spectral library searching to situations where decoy spectra cannot be readily generated, such as in searching unidentified and nonpeptide spectral libraries.

  3. Decoy Methods for Assessing False Positives and False Discovery Rates in Shotgun Proteomics

    PubMed Central

    Wang, Guanghui; Wu, Wells W.; Zhang, Zheng; Masilamani, Shyama; Shen, Rong-Fong

    2008-01-01

    The potential of getting a significant number of false positives (FPs) in peptide-spectrum matches (PSMs) obtained by proteomic database search has been well-recognized. Among the attempts to assess FPs, the concomitant use of target and decoy databases is widely practiced. By adjusting filtering criteria, FPs and false discovery rate (FDR) can be controlled at a desired level. Although the target-decoy approach is gaining in popularity, subtle differences in decoy construction (e.g., reversing vs. stochastic methods), rate calculation (e.g., total vs. unique PSMs), or searching (separate vs. composite) do exist among various implementations. In the present study, we evaluated the effects of these differences on FP and FDR estimations using a rat kidney protein sample and the SEQUEST search engine as an example. On the effects of decoy construction, we found that, when a single scoring filter (XCorr) was used, stochastic methods generated a higher estimation of FPs and FDR than sequence reversing methods, likely due to an increase in unique peptides. This higher estimation could largely be attenuated by creating decoy databases similar in effective size, but not by a simple normalization with a unique-peptide coefficient. When multiple filters were applied, the differences seen between reversing and stochastic methods significantly diminished, suggesting multiple filterings reduce the dependency on how a decoy is constructed. For a fixed set of filtering criteria, FDR and FPs estimated by using unique PSMs were almost twice those using total PSMs. The higher estimation seemed to be dependent on data acquisition setup. As to the differences between performing separate or composite searches, in general, FDR estimated from separate search was about three times that from composite search. The degree of difference gradually decreased as the filtering criteria became more stringent. Paradoxically, the estimated true positives in separate search were higher when multiple

  4. Decoy methods for assessing false positives and false discovery rates in shotgun proteomics.

    PubMed

    Wang, Guanghui; Wu, Wells W; Zhang, Zheng; Masilamani, Shyama; Shen, Rong-Fong

    2009-01-01

    The potential of getting a significant number of false positives (FPs) in peptide-spectrum matches (PSMs) obtained by proteomic database search has been well-recognized. Among the attempts to assess FPs, the concomitant use of target and decoy databases is widely practiced. By adjusting filtering criteria, FPs and false discovery rate (FDR) can be controlled at a desired level. Although the target-decoy approach is gaining in popularity, subtle differences in decoy construction (e.g., reversing vs stochastic methods), rate calculation (e.g., total vs unique PSMs), or searching (separate vs composite) do exist among various implementations. In the present study, we evaluated the effects of these differences on FP and FDR estimations using a rat kidney protein sample and the SEQUEST search engine as an example. On the effects of decoy construction, we found that, when a single scoring filter (XCorr) was used, stochastic methods generated a higher estimation of FPs and FDR than sequence reversing methods, likely due to an increase in unique peptides. This higher estimation could largely be attenuated by creating decoy databases similar in effective size but not by a simple normalization with a unique-peptide coefficient. When multiple filters were applied, the differences seen between reversing and stochastic methods significantly diminished, suggesting multiple filterings reduce the dependency on how a decoy is constructed. For a fixed set of filtering criteria, FDR and FPs estimated by using unique PSMs were almost twice those using total PSMs. The higher estimation seemed to be dependent on data acquisition setup. As to the differences between performing separate or composite searches, in general, FDR estimated from the separate search was about three times that from the composite search. The degree of difference gradually decreased as the filtering criteria became more stringent. Paradoxically, the estimated true positives in separate search were higher when

  5. Practical round-robin differential phase-shift quantum key distribution.

    PubMed

    Zhang, Ying-Ying; Bao, Wan-Su; Zhou, Chun; Li, Hong-Wei; Wang, Yang; Jiang, Mu-Sheng

    2016-09-01

    Recently, a novel protocol named round-robin differential phase-shift (RRDPS) quantum key distribution [Nature 509, 475(2014)] has been proposed. It can estimate information leakage without monitoring bit error rate. In this paper, we study the performance of RRDPS using heralded single photon source (HSPS) without and with decoy-state method, then compare it with the performance of weak coherent pulses (WCPs). From numerical simulation, we can see that HSPS performs better especially for shorter packet and higher bit error rate. Moreover, we propose a general theory of decoy-state method for RRDPS protocol based on only three decoy states and one signal state. Taking WCPs as an example, the three-intensity decoy-state protocol can distribute secret keys over a distance of 128 km when the length of pulses packet is 32, which confirms great practical interest of our method. PMID:27607679

  6. Similarity Mapplet: Interactive Visualization of the Directory of Useful Decoys and ChEMBL in High Dimensional Chemical Spaces.

    PubMed

    Awale, Mahendra; Reymond, Jean-Louis

    2015-08-24

    An Internet portal accessible at www.gdb.unibe.ch has been set up to automatically generate color-coded similarity maps of the ChEMBL database in relation to up to two sets of active compounds taken from the enhanced Directory of Useful Decoys (eDUD), a random set of molecules, or up to two sets of user-defined reference molecules. These maps visualize the relationships between the selected compounds and ChEMBL in six different high dimensional chemical spaces, namely MQN (42-D molecular quantum numbers), SMIfp (34-D SMILES fingerprint), APfp (20-D shape fingerprint), Xfp (55-D pharmacophore fingerprint), Sfp (1024-bit substructure fingerprint), and ECfp4 (1024-bit extended connectivity fingerprint). The maps are supplied in form of Java based desktop applications called "similarity mapplets" allowing interactive content browsing and linked to a "Multifingerprint Browser for ChEMBL" (also accessible directly at www.gdb.unibe.ch ) to perform nearest neighbor searches. One can obtain six similarity mapplets of ChEMBL relative to random reference compounds, 606 similarity mapplets relative to single eDUD active sets, 30,300 similarity mapplets relative to pairs of eDUD active sets, and any number of similarity mapplets relative to user-defined reference sets to help visualize the structural diversity of compound series in drug optimization projects and their relationship to other known bioactive compounds. PMID:26207526

  7. Efficacy of an amphipathic oligopeptide to shuttle and release a cis-acting DNA decoy into human cells.

    PubMed

    Citti, L; Rovero, P; Colombo, M G; Mariani, L; Poliseno, L; Rainaldi, G

    2002-01-01

    We investigated the ability of an amphipathic oligopeptide to carry a synthetic dsDNA oligonucleotide inside human cells. The oligonucleotide was designed as a decoy binding site for the transcriptional activator of the methylguanine-DNA methyltransferase (MGMT) gene. The complex oligopeptide and decoy were administered to MCF10A exponentially growing cells, and the uptake was monitored by flow cytometry. After a 1-h exposure, almost all of the MCF10A cells were fluorescent, indicating that all of the cells had been transfected. By increasing the time, the fluorescence intensity per cell rapidly increased to a plateau at the 8-h time point. RT-PCR analysis of the MGMT gene was used as the molecular readout of the intracellular activity of the DNA decoy. MCF10A cells transfected with the oligopeptide/decoy complex showed a strong reduction in MGMT mRNA. Here, we discuss the advantages of using amphipathic oligopeptides as carriers of short DNA sequences.

  8. Experimental demonstration of counteracting imperfect sources in a practical one-way quantum-key-distribution system

    SciTech Connect

    Xu Fangxing; Zhang Yang; Zhou Zheng; Chen Wei; Han Zhengfu; Guo Guangcan

    2009-12-15

    In a practical quantum-key-distribution system, photon source and small operational errors cause intensity fluctuations inevitably, which cannot be ignored for a precise estimation on the single-photon fraction. In this paper, we demonstrated an efficient three-intensity decoy method scheme on top of the one-way Faraday-Michelson Interferometric system, combining an active monitoring with existing commercial apparatus to inspect fluctuations instantly. With this faithful detection for the upper bound of the fluctuation, the secure quantum key distribution is unconditionally realized with whatever type of intensity errors, which declares the utility and potential of decoy theory and active monitoring for quantum key distribution in practical use.

  9. Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor Growth

    PubMed Central

    Kopechek, Jonathan A.; Carson, Andrew R.; McTiernan, Charles F.; Chen, Xucai; Hasjim, Bima; Lavery, Linda; Sen, Malabika; Grandis, Jennifer R.; Villanueva, Flordeliza S.

    2015-01-01

    Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many cancers where it acts to promote tumor progression. A STAT3-specific transcription factor decoy has been developed to suppress STAT3 downstream signaling, but a delivery strategy is needed to improve clinical translation. Ultrasound-targeted microbubble destruction (UTMD) has been shown to enhance image-guided local delivery of molecular therapeutics to a target site. The objective of this study was to deliver STAT3 decoy to squamous cell carcinoma (SCC) tumors using UTMD to disrupt STAT3 signaling and inhibit tumor growth. Studies performed demonstrated that UTMD treatment with STAT3 decoy-loaded microbubbles inhibited STAT3 signaling in SCC cells in vitro. Studies performed in vivo demonstrated that UTMD treatment with STAT3 decoy-loaded microbubbles induced significant tumor growth inhibition (31-51% reduced tumor volume vs. controls, p < 0.05) in mice bearing SCC tumors. Furthermore, expression of STAT3 downstream target genes (Bcl-xL and cyclin D1) was significantly reduced (34-39%, p < 0.05) in tumors receiving UTMD treatment with STAT3 decoy-loaded microbubbles compared to controls. In addition, the quantity of radiolabeled STAT3 decoy detected in tumors eight hours after treatment was significantly higher with UTMD treatment compared to controls (70-150%, p < 0.05). This study demonstrates that UTMD can increase delivery of a transcription factor decoy to tumors in vivo and that the decoy can inhibit STAT3 signaling and tumor growth. These results suggest that UTMD treatment holds potential for clinical use to increase the concentration of a transcription factor signaling inhibitor in the tumor. PMID:26681983

  10. Bdellovibrio predation in the presence of decoys: Three-way bacterial interactions revealed by mathematical and experimental analyses.

    PubMed

    Hobley, Laura; King, John R; Sockett, R Elizabeth

    2006-10-01

    Bdellovibrio bacteriovorus is a small, gram-negative, motile bacterium that preys upon other gram-negative bacteria, including several known human pathogens. Its predation efficiency is usually studied in pure cultures containing solely B. bacteriovorus and a suitable prey. However, in natural environments, as well as in any possible biomedical uses as an antimicrobial, Bdellovibrio is predatory in the presence of diverse decoys, including live nonsusceptible bacteria, eukaryotic cells, and cell debris. Here we gathered and mathematically modeled data from three-member cultures containing predator, prey, and nonsusceptible bacterial decoys. Specifically, we studied the rate of predation of planktonic late-log-phase Escherichia coli S17-1 prey by B. bacteriovorus HD100, both in the presence and in the absence of Bacillus subtilis nonsporulating strain 671, which acted as a live bacterial decoy. Interestingly, we found that although addition of the live Bacillus decoy did decrease the rate of Bdellovibrio predation in liquid cultures, this addition also resulted in a partially compensatory enhancement of the availability of prey for predation. This effect resulted in a higher final yield of Bdellovibrio than would be predicted for a simple inert decoy. Our mathematical model accounts for both negative and positive effects of predator-prey-decoy interactions in the closed batch environment. In addition, it informs considerations for predator dosing in any future therapeutic applications and sheds some light on considerations for modeling the massively complex interactions of real mixed bacterial populations in nature.

  11. Integration of decoy domains derived from protein targets of pathogen effectors into plant immune receptors is widespread.

    PubMed

    Kroj, Thomas; Chanclud, Emilie; Michel-Romiti, Corinne; Grand, Xavier; Morel, Jean-Benoit

    2016-04-01

    Plant immune receptors of the class of nucleotide-binding and leucine-rich repeat domain (NLR) proteins can contain additional domains besides canonical NB-ARC (nucleotide-binding adaptor shared by APAF-1, R proteins, and CED-4 (NB-ARC)) and leucine-rich repeat (LRR) domains. Recent research suggests that these additional domains act as integrated decoys recognizing effectors from pathogens. Proteins homologous to integrated decoys are suspected to be effector targets and involved in disease or resistance. Here, we scrutinized 31 entire plant genomes to identify putative integrated decoy domains in NLR proteins using the Interpro search. The involvement of the Zinc Finger-BED type (ZBED) protein containing a putative decoy domain, called BED, in rice (Oryza sativa) resistance was investigated by evaluating susceptibility to the blast fungus Magnaporthe oryzae in rice over-expression and knock-out mutants. This analysis showed that all plants tested had integrated various atypical protein domains into their NLR proteins (on average 3.5% of all NLR proteins). We also demonstrated that modifying the expression of the ZBED gene modified disease susceptibility. This study suggests that integration of decoy domains in NLR immune receptors is widespread and frequent in plants. The integrated decoy model is therefore a powerful concept to identify new proteins involved in disease resistance. Further in-depth examination of additional domains in NLR proteins promises to unravel many new proteins of the plant immune system. PMID:26848538

  12. Monte Carlo simulation of a quantum noise limited Čerenkov detector based on air-spaced light guiding taper for megavoltage x-ray imaging

    SciTech Connect

    Teymurazyan, A.; Rowlands, J. A.; Pang, G.

    2014-04-15

    Purpose: Electronic Portal Imaging Devices (EPIDs) have been widely used in radiation therapy and are still needed on linear accelerators (Linacs) equipped with kilovoltage cone beam CT (kV-CBCT) or MRI systems. Our aim is to develop a new high quantum efficiency (QE) Čerenkov Portal Imaging Device (CPID) that is quantum noise limited at dose levels corresponding to a single Linac pulse. Methods: Recently a new concept of CPID for MV x-ray imaging in radiation therapy was introduced. It relies on Čerenkov effect for x-ray detection. The proposed design consisted of a matrix of optical fibers aligned with the incident x-rays and coupled to an active matrix flat panel imager (AMFPI) for image readout. A weakness of such design is that too few Čerenkov light photons reach the AMFPI for each incident x-ray and an AMFPI with an avalanche gain is required in order to overcome the readout noise for portal imaging application. In this work the authors propose to replace the optical fibers in the CPID with light guides without a cladding layer that are suspended in air. The air between the light guides takes on the role of the cladding layer found in a regular optical fiber. Since air has a significantly lower refractive index (∼1 versus 1.38 in a typical cladding layer), a much superior light collection efficiency is achieved. Results: A Monte Carlo simulation of the new design has been conducted to investigate its feasibility. Detector quantities such as quantum efficiency (QE), spatial resolution (MTF), and frequency dependent detective quantum efficiency (DQE) have been evaluated. The detector signal and the quantum noise have been compared to the readout noise. Conclusions: Our studies show that the modified new CPID has a QE and DQE more than an order of magnitude greater than that of current clinical systems and yet a spatial resolution similar to that of current low-QE flat-panel based EPIDs. Furthermore it was demonstrated that the new CPID does not require an

  13. Double-stranded RNA transcribed from vector-based oligodeoxynucleotide acts as transcription factor decoy.

    PubMed

    Xiao, Xiao; Gang, Yi; Wang, Honghong; Wang, Jiayin; Zhao, Lina; Xu, Li; Liu, Zhiguo

    2015-02-01

    In this study, we designed a short hairpin RNA vector-based oligodeoxynucleotide (VB-ODN) carrying transcription factor (TF) consensus sequence which could function as a decoy to block TF activity. Specifically, VB-ODN for Nuclear factor-κB (NF-κB) could inhibit cell viability and decrease downstream gene expression in HEK293 cells without affecting expression of NF-κB itself. The specific binding between VB-ODN produced double-stranded RNA and NF-κB was evidenced by electrophoretic mobility shift assay. Moreover, similar VB-ODNs designed for three other TFs also inhibit their downstream gene expression but not that of themselves. Our study provides a new design of decoy for blocking TF activity.

  14. Toward pest control via mass production of realistic decoys of insects

    NASA Astrophysics Data System (ADS)

    Pulsifer, Drew P.; Lakhtakia, Akhlesh; Kumar, Jayant; Baker, Thomas C.; Martín-Palma, Raúl J.

    2012-04-01

    The emerald ash borer (EAB), Agrilus planipennis, is an invasive species of beetles threatening the ash trees of North America. The species exhibits a mating behavior in which a flying male will first spot a stationary female at rest and then execute a pouncing maneuver to dive sharply onto her. The pouncing behavior appears to be cued by some visual signal from the top surface of the female's body. We have adopted bioreplication techniques to fabricate artificial visual decoys that could be used to detect, monitor, and slow the spread of EAB populations across North America. Using a negative die made of nickel and a positive die made of a hard polymer, we have stamped a polymer sheet to produce these decoys. Our bioreplication procedure is industrially scalable.

  15. Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor

    SciTech Connect

    Alexander-Brett, Jennifer M.; Fremont, Daved H.

    2008-09-23

    Viruses have evolved a myriad of evasion strategies focused on undermining chemokine-mediated immune surveillance, exemplified by the mouse {gamma}-herpesvirus 68 M3 decoy receptor. Crystal structures of M3 in complex with C chemokine ligand 1/lymphotactin and CC chemokine ligand 2/monocyte chemoattractant protein 1 reveal that invariant chemokine features associated with G protein-coupled receptor binding are primarily recognized by the decoy C-terminal domain, whereas the N-terminal domain (NTD) reconfigures to engage divergent basic residue clusters on the surface of chemokines. Favorable electrostatic forces dramatically enhance the association kinetics of chemokine binding by M3, with a primary role ascribed to acidic NTD regions that effectively mimic glycosaminoglycan interactions. Thus, M3 employs two distinct mechanisms of chemical imitation to potently sequester chemokines, thereby inhibiting chemokine receptor binding events as well as the formation of chemotactic gradients necessary for directed leukocyte trafficking.

  16. Surveillance of influenza viruses in waterfowl used as decoys in Andalusia, Spain.

    PubMed

    Jurado-Tarifa, Estefanía; Napp, Sebastian; Gómez-Pacheco, Juan Manuel; Fernández-Morente, Manuel; Jaén-Téllez, Juan Antonio; Arenas, Antonio; García-Bocanegra, Ignacio

    2014-01-01

    A longitudinal study was carried out to determine the seroprevalence of avian influenza viruses (AIVs) in waterfowl used as decoys in Andalusia, southern Spain. A total of 2319 aquatic birds from 193 flocks were analyzed before and after the hunting season 2011-2012. In the first sampling, 403 out of 2319 (18.0%, CI95%: 15.8-19.0) decoys showed antibodies against AIVs by ELISA. The AI seroprevalence was significantly higher in geese (21.0%) than in ducks (11.7%) (P<0.001). Besides, the spatial distribution of AIVs was not homogeneous as significant differences among regions were observed. The prevalence of antibodies against AIVs subtypes H5 and H7 were 1.1% and 0.3%, respectively, using hemagglutination inhibition test (HI). The overall and H5 seroprevalences slightly increased after the hunting period (to 19.2% and 1.4%, respectively), while the H7 seroprevalence remained at the same level (0.3%). The proportion of flocks infected by AIVs was 65.3%, while 11.2% and 4.9% of flocks were positive for H5 and H7, respectively. Viral shedding was not detected in any of the 47 samples positive by both ELISA and HI, tested by RRT-PCR. The individual incidence after the hunting season was 3.4%. The fact that 57 animals seroconverted, 15 of which were confirmed by HI (12 H5 and 3 H7), was indication of contact with AIVs during the hunting period. The results indicate that waterfowl used as decoys are frequently exposed to AIVs and may be potentially useful as sentinels for AIVs monitoring. The seroprevalence detected and the seropositivity against AIVs H5 and H7, suggest that decoys can act as reservoirs of AIVs, which may be of animal and public health concern.

  17. Surveillance of Influenza Viruses in Waterfowl Used As Decoys in Andalusia, Spain

    PubMed Central

    Jurado-Tarifa, Estefanía; Napp, Sebastian; Gómez-Pacheco, Juan Manuel; Fernández-Morente, Manuel; Jaén-Téllez, Juan Antonio; Arenas, Antonio; García-Bocanegra, Ignacio

    2014-01-01

    A longitudinal study was carried out to determine the seroprevalence of avian influenza viruses (AIVs) in waterfowl used as decoys in Andalusia, southern Spain. A total of 2319 aquatic birds from 193 flocks were analyzed before and after the hunting season 2011–2012. In the first sampling, 403 out of 2319 (18.0%, CI95%: 15.8–19.0) decoys showed antibodies against AIVs by ELISA. The AI seroprevalence was significantly higher in geese (21.0%) than in ducks (11.7%) (P<0.001). Besides, the spatial distribution of AIVs was not homogeneous as significant differences among regions were observed. The prevalence of antibodies against AIVs subtypes H5 and H7 were 1.1% and 0.3%, respectively, using hemagglutination inhibition test (HI). The overall and H5 seroprevalences slightly increased after the hunting period (to 19.2% and 1.4%, respectively), while the H7 seroprevalence remained at the same level (0.3%). The proportion of flocks infected by AIVs was 65.3%, while 11.2% and 4.9% of flocks were positive for H5 and H7, respectively. Viral shedding was not detected in any of the 47 samples positive by both ELISA and HI, tested by RRT-PCR. The individual incidence after the hunting season was 3.4%. The fact that 57 animals seroconverted, 15 of which were confirmed by HI (12 H5 and 3 H7), was indication of contact with AIVs during the hunting period. The results indicate that waterfowl used as decoys are frequently exposed to AIVs and may be potentially useful as sentinels for AIVs monitoring. The seroprevalence detected and the seropositivity against AIVs H5 and H7, suggest that decoys can act as reservoirs of AIVs, which may be of animal and public health concern. PMID:24901946

  18. Beating the photon-number-splitting attack in practical quantum cryptography.

    PubMed

    Wang, Xiang-Bin

    2005-06-17

    We propose an efficient method to verify the upper bound of the fraction of counts caused by multiphoton pulses in practical quantum key distribution using weak coherent light, given whatever type of Eve's action. The protocol simply uses two coherent states for the signal pulses and vacuum for the decoy pulse. Our verified upper bound is sufficiently tight for quantum key distribution with a very lossy channel, in both the asymptotic and nonasymptotic case. So far our protocol is the only decoy-state protocol that works efficiently for currently existing setups.

  19. Double-stranded RNA transcribed from vector-based oligodeoxynucleotide acts as transcription factor decoy

    SciTech Connect

    Xiao, Xiao; Gang, Yi; Wang, Honghong; Wang, Jiayin; Zhao, Lina; Xu, Li; Liu, Zhiguo

    2015-02-06

    Highlights: • A shRNA vector based transcription factor decoy, VB-ODN, was designed. • VB-ODN for NF-κB inhibited cell viability in HEK293 cells. • VB-ODN inhibited expression of downstream genes of target transcription factors. • VB-ODN may enhance nuclear entry ratio for its feasibility of virus production. - Abstract: In this study, we designed a short hairpin RNA vector-based oligodeoxynucleotide (VB-ODN) carrying transcription factor (TF) consensus sequence which could function as a decoy to block TF activity. Specifically, VB-ODN for Nuclear factor-κB (NF-κB) could inhibit cell viability and decrease downstream gene expression in HEK293 cells without affecting expression of NF-κB itself. The specific binding between VB-ODN produced double-stranded RNA and NF-κB was evidenced by electrophoretic mobility shift assay. Moreover, similar VB-ODNs designed for three other TFs also inhibit their downstream gene expression but not that of themselves. Our study provides a new design of decoy for blocking TF activity.

  20. Manipulating lek size and composition using decoys: an experimental investigation of lek evolution models.

    PubMed

    Jiguet, Frédéric; Bretagnolle, Vincent

    2006-12-01

    Four theoretical models have been proposed to account for the origin and maintenance of leks: hotspot, female preference, hotshot, and black hole models. Each has been validated in particular cases, and most are not mutually exclusive; therefore, it has been difficult to contrast and separate them, empirically and experimentally. By using decoys to mimic natural leks in the little bustard, artificial leks attracted wild birds. Then, by manipulating artificial lek size and structure (sex ratio, male phenotype), the study of responses of wild males and females allowed us to test specific predictions derived from the four classical models of lek evolution. The hotspot model was not supported because female decoys did not attract wild males. Conversely, hotshot males do exist in this species (attracting both wild females and males), as does a female preference for a particular lek size (four males). Finally, males aggressive toward decoys attracted fewer females, consistent with one of the mechanisms by which the black hole model may work. Therefore, three models of lek evolution were partly or fully supported by our experimental results: hotshot, female preference, and black hole models. We suggest that these models actually fit within each other, ensuring the evolution, functioning, and long-term maintenance of leks. PMID:17109318

  1. Enhanced Anti-tumor Reactivity of Cytotoxic T Lymphocytes Expressing PD-1 Decoy.

    PubMed

    Shin, Jae Hun; Park, Hyung Bae; Choi, Kyungho

    2016-04-01

    Programmed death-1 (PD-1) is a strong negative regulator of T lymphocytes in tumor-microenvironment. By engaging PD-1 ligand (PD-L1) on tumor cells, PD-1 on T cell surface inhibits anti-tumor reactivity of tumor-infiltrating T cells. Systemic blockade of PD-1 function using blocking antibodies has shown significant therapeutic efficacy in clinical trials. However, approximately 10 to 15% of treated patients exhibited serious autoimmune responses due to the activation of self-reactive lymphocytes. To achieve selective activation of tumor-specific T cells, we generated T cells expressing a dominant-negative deletion mutant of PD-1 (PD-1 decoy) via retroviral transduction. PD-1 decoy increased IFN-γ secretion of antigen-specific T cells in response to tumor cells expressing the cognate antigen. Adoptive transfer of PD-1 decoy-expressing T cells into tumor-bearing mice potentiated T cell-mediated tumor regression. Thus, T cell-specific blockade of PD-1 could be a useful strategy for enhancing both efficacy and safety of anti-tumor T cell therapy. PMID:27162530

  2. An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

    DOE PAGES

    Kariolis, Mihalis S.; Miao, Yu Rebecca; Jones, Douglas S.; Kapur, Shiven; Mathews, Irimpan I.; Giaccia, Amato J.; Cochran, Jennifer R.

    2014-09-21

    Aberrant signaling through the Axl receptor tyrosine kinase has been associated with a myriad of human diseases, most notably metastatic cancer, identifying Axl and its ligand Gas6 as important therapeutic targets. Using rational and combinatorial approaches, we engineered an Axl ‘decoy receptor’ that binds Gas6 with high affinity and inhibits its function, offering an alternative approach from drug discovery efforts that directly target Axl. Four mutations within this high affinity Axl variant caused structural alterations in side chains across the Gas6/Axl binding interface, stabilizing a conformational change on Gas6. When reformatted as an Fc-fusion, the engineered decoy receptor bound tomore » Gas6 with femtomolar affinity, an 80-fold improvement compared to the wild-type Axl receptor, allowing effective sequestration of Gas6 and specific abrogation of Axl signaling. Additionally, increased Gas6 binding affinity was critical and correlative with the ability of decoy receptors to potently inhibit metastasis and disease progression in vivo.« less

  3. EDITORIAL: Focus on Quantum Cryptography: Theory and Practice FOCUS ON QUANTUM CRYPTOGRAPHY: THEORY AND PRACTICE

    NASA Astrophysics Data System (ADS)

    Lütkenhaus, N.; Shields, A. J.

    2009-04-01

    superconducting single-photon detectors Lijun Ma, S Nam, Hai Xu, B Baek, Tiejun Chang, O Slattery, A Mink and Xiao Tang Practical gigahertz quantum key distribution based on avalanche photodiodes Z L Yuan, A R Dixon, J F Dynes, A W Sharpe and A J Shields Simple security proof of quantum key distribution based on complementarity M Koashi Feasibility of satellite quantum key distribution C Bonato, A Tomaello, V Da Deppo, G Naletto and P Villoresi Programmable instrumentation and gigahertz signaling for single-photon quantum communication systems Alan Mink, Joshua C Bienfang, Robert Carpenter, Lijun Ma, Barry Hershman, Alessandro Restelli and Xiao Tang Experimental polarization encoded quantum key distribution over optical fibres with real-time continuous birefringence compensation G B Xavier, N Walenta, G Vilela de Faria, G P Temporão, N Gisin, H Zbinden and J P von der Weid Feasibility of free space quantum key distribution with coherent polarization states D Elser, T Bartley, B Heim, Ch Wittmann, D Sych and G Leuchs A fully automated entanglement-based quantum cryptography system for telecom fiber networks Alexander Treiber, Andreas Poppe, Michael Hentschel, Daniele Ferrini, Thomas Lorünser, Edwin Querasser, Thomas Matyus, Hannes Hübel and Anton Zeilinger Dense wavelength multiplexing of 1550 nm QKD with strong classical channels in reconfigurable networking environments N A Peters, P Toliver, T E Chapuran, R J Runser, S R McNown, C G Peterson, D Rosenberg, N Dallmann, R J Hughes, K P McCabe, J E Nordholt and K T Tyagi Clock synchronization by remote detection of correlated photon pairs Caleb Ho, Antía Lamas-Linares and Christian Kurtsiefer Megabits secure key rate quantum key distribution Q Zhang, H Takesue, T Honjo, K Wen, T Hirohata, M Suyama, Y Takiguchi, H Kamada, Y Tokura, O Tadanaga, Y Nishida, M Asobe and Y Yamamoto Practical long-distance quantum key distribution system using decoy levels D Rosenberg, C G Peterson, J W Harrington, P R Rice, N Dallmann, K T Tyagi, K P

  4. Investigation of quantum efficiency in mid-wave infrared (MWIR) InAs/GaSb type-II strained layer superlattice (T2SL) detectors

    NASA Astrophysics Data System (ADS)

    Acosta, Lilian; Klein, Brianna; Tian, Zhao-Bing; Frantz, Eric; Myers, Stephen; Gautam, Nutan; Schuler-Sandy, Ted; Plis, Elena; Krishna, Sanjay

    2014-02-01

    The objective of this study is to optimize the absorption in the active region of InAs/GaSb T2SL photodetectors for the realization of high-performance MWIR devices. Two sets of MWIR (λ100% cut-off ~ 5.5μm at 77K) T2SL detectors were realized; one set with varied detector absorber thickness, the other set with varied T2SL period. The T2SL material quality was evaluated on the basis of room temperature photoluminescence (RTPL) and the high-resolution X-ray diffraction (HRXRD) data. Then the device performance was compared using spectral response, dark current and responsivity measurements. Finally, quantum efficiency was calculated and employed as a metric for the definition of the optimal T2SL period and active region thickness. For the first part of the study, a homojunction pin architecture based on 8 monolayers (MLs) InAs/8MLs GaSb T2SL was used. The thickness of the non-intentionally doped absorber layers were 1.5μm, 2.5μm, and 3.5μm. For the second part of the study, unipolar barrier (pBiBn) devices were grown. The thickness of the absorber region and the T2SL constituent InAs layer thicknesses were kept the same (1.5 μm and 8 MLs, respectively) whereas the T2SL constituent GaSb thickness was varied as 6 MLs, 8 MLs, and 10 MLs. We have found that the pin detector with 2.5 μm thick absorber and the pBiBn detector with 8 ML InAs/ 8 ML GaSb T2SL composition are, within the scope of this study, optimal for the realization of MWIR single-element devices and FPAs with corresponding architectures.

  5. A universal quantum key distribution method

    NASA Astrophysics Data System (ADS)

    Zhang, He-qing; Zhou, Yuan-yuan; Zhou, Xue-jun; Tian, Pei-gen

    2013-09-01

    Combining heralded pair coherent state (HPCS) with passive decoy-state idea, a new method is presented for quantum key distribution (QKD). The weak coherent source (WCS) and heralded single photon source (HSPS) are the most common photon sources for state-of-the-art QKD. However, there is a prominent crossover between the maximum secure distance and the secure key generation rate if these two sources are applied in a practical decoy-state QKD. The method in this paper does not prepare decoy states actively. Therefore, it uses the same experimental setup as the conventional protocol, and there is no need for a hardware change, so its implementation is very easy. Furthermore, the method can obtain a longer secure transmission distance, and its key generation rate is higher than that of the passive decoy-state method with WCS or HSPS in the whole secure transmission distance. Thus, the limitation of the mentioned photo sources for QKD is broken through. So the method is universal in performance and implementation.

  6. Quantum Erasure Cryptography

    NASA Astrophysics Data System (ADS)

    Salih, Hatim

    2016-05-01

    The phenomenon of quantum erasure has long intrigued physicists, but has surprisingly found limited practical application. Here, we propose a protocol for quantum key distribution (QKD) based on quantum erasure, promising inherent security against detector attacks. We particularly demonstrate its security against a powerful detector-blinding attack.

  7. Advanced UV Detectors and Detector Arrays

    NASA Technical Reports Server (NTRS)

    Pankove, Jacques I.; Torvik, John

    1998-01-01

    Gallium Nitride (GaN) with its wide energy bandgap of 3.4 eV holds excellent promise for solar blind UV detectors. We have successfully designed, fabricated and tested GaN p-i-n detectors and detector arrays. The detectors have a peak responsivity of 0.14A/W at 363 nm (3.42 eV) at room temperature. This corresponds to an internal quantum efficiency of 56%. The responsivity decreases by several orders of magnitude to 0.008 A/W at 400 nm (3.10 eV) giving the excellent visible rejection ratio needed for solar-blind applications.

  8. ZnCdMgSe as a Materials Platform for Advanced Photonic Devices: Broadband Quantum Cascade Detectors and Green Semiconductor Disk Lasers

    NASA Astrophysics Data System (ADS)

    De Jesus, Joel

    The ZnCdMgSe family of II-VI materials has unique and promising characteristics that may be useful in practical applications. For example they can be grown lattice matched to InP substrates with lattice matched bandgaps that span from 2.1 to 3.5 eV, they can be successfully doped n-type, have a large conduction band offset (CBO) with no intervalley scattering present when strained, they have lower average phonon energies, and the InP lattice constant lies in the middle of the ZnSe and CdSe binaries compounds giving room to experiment with tensile and compressive stress. However they have not been studied in detail for use in practical devices. Here we have identified two types of devices that are being currently developed that benefit from the ZnCdMgSe-based material properties. These are the intersubband (ISB) quantum cascade (QC) detectors and optically pumped semiconductor lasers that emit in the visible range. The paucity for semiconductor lasers operating in the green-orange portion of the visible spectrum can be easily overcome with the ZnCdMgSe materials system developed in our research. The non-strain limited, large CBO available allows to expand the operating wavelength of ISB devices providing shorter and longer wavelengths than the currently commercially available devices. This property can also be exploited to develop broadband room temperature operation ISB detectors. The work presented here focused first on using the ZnCdMgSe-based material properties and parameter to understand and predict the interband and intersubband transitions of its heterostructures. We did this by studying an active region of a QC device by contactless electroreflectance, photoluminescence, FTIR transmittance and correlating the measurements to the quantum well structure by transfer matrix modeling. Then we worked on optimizing the ZnCdMgSe material heterostructures quality by studying the effects of growth interruptions on their optical and optoelectronic properties of

  9. Photon detectors

    SciTech Connect

    Va`vra, J.

    1995-10-01

    J. Seguinot and T. Ypsilantis have recently described the theory and history of Ring Imaging Cherenkov (RICH) detectors. In this paper, I will expand on these excellent review papers, by covering the various photon detector designs in greater detail, and by including discussion of mistakes made, and detector problems encountered, along the way. Photon detectors are among the most difficult devices used in physics experiments, because they must achieve high efficiency for photon transport and for the detection of single photo-electrons. For gaseous devices, this requires the correct choice of gas gain in order to prevent breakdown and wire aging, together with the use of low noise electronics having the maximum possible amplification. In addition, the detector must be constructed of materials which resist corrosion due to photosensitive materials such as, the detector enclosure must be tightly sealed in order to prevent oxygen leaks, etc. The most critical step is the selection of the photocathode material. Typically, a choice must be made between a solid (CsI) or gaseous photocathode (TMAE, TEA). A conservative approach favors a gaseous photocathode, since it is continuously being replaced by flushing, and permits the photon detectors to be easily serviced (the air sensitive photocathode can be removed at any time). In addition, it can be argued that we now know how to handle TMAE, which, as is generally accepted, is the best photocathode material available as far as quantum efficiency is concerned. However, it is a very fragile molecule, and therefore its use may result in relatively fast wire aging. A possible alternative is TEA, which, in the early days, was rejected because it requires expensive CaF{sub 2} windows, which could be contaminated easily in the region of 8.3 eV and thus lose their UV transmission.

  10. Optimization of the configuration of a symmetric three-barrier resonant-tunneling structure as an active element of a quantum cascade detector

    SciTech Connect

    Tkach, N. V. Seti, Ju. A.

    2011-03-15

    On the basis of a model of rectangular potentials and different electron effective masses in wells and barriers of an open resonant-tunneling structure with identical outer barriers, a theory has been developed and the dynamic conductance caused by the interaction of the electromagnetic field with electrons passing through the structure has been calculated. Using the example of the three-barrier resonant-tunneling structure with In{sub 0.53}Ga{sub 0.47}As wells and In{sub 0.52}Al{sub 0.48}As barriers, it is shown that, independently of the geometrical sizes of potential wells and barriers, there exist three geometrical configurations (positions of the inner barrier with respect to outer ones) at which the nanosystem, as an active element, provides optimum operating conditions of the quantum cascade detector.

  11. A membrane-bound Fas decoy receptor expressed by human thymocytes.

    PubMed

    Jenkins, M; Keir, M; McCune, J M

    2000-03-17

    Human thymocytes at several stages of maturation express Fas, yet resist apoptosis induction through its ligation. A proximal step in apoptotic signaling through Fas is implicated in this resistance, as these cells undergo normal levels of apoptosis induction after exposure to tumor necrosis factor-alpha. We studied the Fas receptors expressed in human thymocytes to search for mechanisms of receptor-mediated inhibition of Fas signaling in these cells. We describe here a unique, membrane-bound form of Fas receptor that contained a complete extracellular domain of Fas but that lacked a death domain due to alternative splicing of exon 7. This Fas decoy receptor (FDR) was shown to have nearly wild-type ability to bind native human Fas ligand and was expressed predominantly at the plasma membrane. Unlike soluble forms of Fas receptor, FDR dominantly inhibited apoptosis induction by Fas ligand in transfected human embryonic kidney cells. Titration of FDR in Fas-expressing cells suggests that FDR may operate through the formation of mixed receptor complexes. FDR also dominantly inhibited Fas-induced apoptosis in Jurkat T cells. In mixing experiments with wild-type Fas, FDR was capable of inhibiting death signaling at molar ratios less than 0.5, and this relative level of FDR:wild type message was observed in at least some thymocytes tested. The data suggest that Fas signal pathways in primary human cells may be regulated by expression of a membrane-bound decoy receptor, analogous to the regulation of tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis by decoy receptors.

  12. Learning from decoys to improve the sensitivity and specificity of proteomics database search results.

    PubMed

    Yadav, Amit Kumar; Kumar, Dhirendra; Dash, Debasis

    2012-01-01

    The statistical validation of database search results is a complex issue in bottom-up proteomics. The correct and incorrect peptide spectrum match (PSM) scores overlap significantly, making an accurate assessment of true peptide matches challenging. Since the complete separation between the true and false hits is practically never achieved, there is need for better methods and rescoring algorithms to improve upon the primary database search results. Here we describe the calibration and False Discovery Rate (FDR) estimation of database search scores through a dynamic FDR calculation method, FlexiFDR, which increases both the sensitivity and specificity of search results. Modelling a simple linear regression on the decoy hits for different charge states, the method maximized the number of true positives and reduced the number of false negatives in several standard datasets of varying complexity (18-mix, 49-mix, 200-mix) and few complex datasets (E. coli and Yeast) obtained from a wide variety of MS platforms. The net positive gain for correct spectral and peptide identifications was up to 14.81% and 6.2% respectively. The approach is applicable to different search methodologies--separate as well as concatenated database search, high mass accuracy, and semi-tryptic and modification searches. FlexiFDR was also applied to Mascot results and showed better performance than before. We have shown that appropriate threshold learnt from decoys, can be very effective in improving the database search results. FlexiFDR adapts itself to different instruments, data types and MS platforms. It learns from the decoy hits and sets a flexible threshold that automatically aligns itself to the underlying variables of data quality and size.

  13. Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo

    PubMed Central

    Falsone, Angelika; Wabitsch, Veronica; Geretti, Elena; Potzinger, Heide; Gerlza, Tanja; Robinson, James; Adage, Tiziana; Teixeira, Mauro M.; Kungl, Andreas J.

    2013-01-01

    IL (interleukin)-8 [CXCL8 (CXC chemokine ligand 8)] exerts its role in inflammation by triggering neutrophils via its specific GPCRs (G-protein-coupled receptors), CXCR1 (CXC chemokine receptor 1) and CXCR2, for which additional binding to endothelial HS-GAGs (heparan sulphate-glycosaminoglycans) is required. We present here a novel approach for blocking the CXCL8-related inflammatory cascade by generating dominant-negative CXCL8 mutants with improved GAG-binding affinity and knocked-out CXCR1/CXCR2 activity. These non-signalling CXCL8 decoy proteins are able to displace WT (wild-type) CXCL8 and to prevent CXCR1/CXCR2 signalling thereby interfering with the inflammatory response. We have designed 14 CXCL8 mutants that we subdivided into three classes according to number and site of mutations. The decoys were characterized by IFTs (isothermal fluorescence titrations) and SPR (surface plasmon resonance) to determine GAG affinity. Protein stability and structural changes were evaluated by far-UV CD spectroscopy and knocked-out GPCR response was shown by Boyden chamber and Ca2+ release assays. From these experiments, CXCL8(Δ6F17KF21KE70KN71K) emerged with the most promising in vitro characteristics. This mutant was therefore further investigated in a murine model of mBSA (methylated BSA)-induced arthritis in mice where it showed strong anti-inflammatory activity. Based on these results, we propose that dominant-negative CXCL8 decoy proteins are a promising class of novel biopharmaceuticals with high therapeutic potential in inflammatory diseases. PMID:23919527

  14. Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer

    PubMed Central

    GE, ZHICHENG; SANDERS, ANDREW J.; YE, LIN; JIANG, WEN G.

    2011-01-01

    Death receptor-3 (DR3) and death decoy receptor-3 (DcR3) are both members of the tumour necrosis factor receptor (TNFR) superfamily. The TNFR superfamily contains eight death domain-containing receptors, including TNFR1 (also called DR1), Fas (also called DR2), DR3, DR4, DR5, DR6, NGFR and EDAR. Upon the binding of these receptors with their corresponding ligands, the death domain recruits various proteins that mediate both the death and proliferation of cells. Receptor function is negatively regulated by decoy receptors (DcR1, DcR2, DcR3 and OPG). DR3/DcR3 are a pair of positive and negative players with which vascular endothelial growth inhibitor (VEGI) interacts. VEGI has been suggested to be a potential tumour suppressor. The inhibitory effects of VEGI on cancer are manifested in three main areas: a direct effect on cancer cells, an anti-angiogenic effect on endothelial cells, and the stimulation of dendritic cell maturation. A recent study indicated that DR3 may be a new receptor for E-selectin, which has been reported to be associated with cancer metastasis. DcR3 is a soluble receptor, highly expressed in various tumours, which lacks an apparent transmembrane segment, prevents cytokine response through ligand binding and neutralization, and is an inhibitor of apoptosis. DcR3 serves as a decoy receptor for FasL, LIGHT and VEGI. The cytokine LIGHT activates various anti-tumour functions and is expected to be a promising candidate for cancer therapy. Certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing DcR3, which blocks FasL function. DR3/DcR3 play profound roles in regulating cell death and proliferation in cancer. The present review briefly discusses DR3/DcR3 and attempts to elucidate the role of these negative and positive players in cancer. PMID:22977485

  15. Approach jamming effectiveness evaluation for surface-type infrared decoy in network centric warship formation

    NASA Astrophysics Data System (ADS)

    Lv, Mingshan

    2015-10-01

    The passive and photoelectrical jamming to anti-ship missile in the condition of network centric warship formation is an important research issue of fleet EW operation. An approach jamming method of shipborne surface-type infrared decoy countering the infrared image guided anti-ship missile is put forward. By analyzing the countering process the jamming effectiveness evaluation model is constructed. By simulation the method is proved t reasonable and effective. This method breaks through the traditional restrict that the passive and photoelectricity jamming measure can only be used in the end self-defence and provides a new method for network centric worship formation to support each other.

  16. Aptamer-Mediated Codelivery of Doxorubicin and NF-κB Decoy Enhances Chemosensitivity of Pancreatic Tumor Cells

    PubMed Central

    Porciani, David; Tedeschi, Lorena; Marchetti, Laura; Citti, Lorenzo; Piazza, Vincenzo; Beltram, Fabio; Signore, Giovanni

    2015-01-01

    Aptamers able to bind efficiently cell-surface receptors differentially expressed in tumor and in healthy cells are emerging as powerful tools to perform targeted anticancer therapy. Here, we present a novel oligonucleotide chimera, composed by an RNA aptamer and a DNA decoy. Our assembly is able to (i) target tumor cells via an antitransferrin receptor RNA aptamer and (ii) perform selective codelivery of a chemotherapeutic drug (Doxorubicin) and of an inhibitor of a cell-survival factor, the nuclear factor κB decoy oligonucleotide. Both payloads are released under conditions found in endolysosomal compartments (low pH and reductive environment). Targeting and cytotoxicity of the oligonucleotidic chimera were assessed by confocal microscopy, cell viability, and Western blot analysis. These data indicated that the nuclear factor κB decoy does inhibit nuclear factor κB activity and ultimately leads to an increased therapeutic efficacy of Doxorubicin selectively in tumor cells. PMID:25919089

  17. Time-resolved measurement of pulse-to-pulse heating effects in a terahertz quantum cascade laser using an NbN superconducting detector

    NASA Astrophysics Data System (ADS)

    Valavanis, A.; Dean, P.; Scheuring, A.; Salih, M.; Stockhausen, A.; Wuensch, S.; Il'in, K.; Chowdhury, S.; Khanna, S. P.; Siegel, M.; Davies, A. G.; Linfield, E. H.

    2013-08-01

    Joule heating causes significant degradation in the power emitted from terahertz-frequency quantum-cascade lasers (THz QCLs). However, to date, it has not been possible to characterize the thermal equilibration time of these devices, since THz power degradation over sub-millisecond time-scales cannot be resolved using conventional bolometric or pyroelectric detectors. In this letter, we use a superconducting antenna-coupled niobium nitride detector to measure the emission from a THz QCL with a nanosecond-scale time-resolution. The emitted THz power is shown to decay more rapidly at higher heat-sink temperatures, and in steady-state the power reduces as the repetition rate of the driving pulses increases. The pulse-to-pulse variation in active-region temperature is inferred by comparing the THz signals with those obtained from low duty-cycle measurements. A thermal resistance of 8.2 ± 0.6 K/W is determined, which is in good agreement with earlier measurements, and we calculate a 370 ± 90-μs bulk heat-storage time, which corresponds to the simulated heat capacity of the device substrate.

  18. Oxidized ultrashort nanotubes as carbon scaffolds for the construction of cell-penetrating NF-kappaB decoy molecules.

    PubMed

    Crinelli, Rita; Carloni, Elisa; Menotta, Michele; Giacomini, Elisa; Bianchi, Marzia; Ambrosi, Gianluca; Giorgi, Luca; Magnani, Mauro

    2010-05-25

    Oligonucleotide (ODN) decoys are synthetic ODNs containing the DNA binding sequence of a transcription factor. When delivered to cells, these molecules can compete with endogenous sequences for binding the transcription factor, thus inhibiting its ability to activate the expression of target genes. Modulation of gene expression by decoy ODNs against nuclear factor-kappaB (NF-kappaB), a transcription factor regulating many genes involved in immunity, has been achieved in a variety of immune/inflammatory disorders. However, the successful use of transcription factor decoys depends on an efficient means to bring the synthetic DNA to target cells. It is known that single-walled carbon nanotubes (SWCNTs), under certain conditions, are able to cross the cell membrane. Thus, we have evaluated the possibility to functionalize SWCNTs with decoy ODNs against NF-kappaB in order to improve their intracellular delivery. To couple ODNs to CNTs, we have exploited the carbodiimide chemistry which allows covalent binding of amino-modified ODNs to carboxyl groups introduced onto SWCNTs through oxidation. The effective binding of ODNs to nanotubes has been demonstrated by a combination of microscopic, spectroscopic, and electrophoretic techniques. The uptake and subcellular distribution of ODN decoys bound to SWCNTs was analyzed by fluorescence microscopy. ODNs were internalized into macrophages and accumulated in the cytosol. Moreover, no cytotoxicity associated with SWCNT administration was observed. Finally, NF-kappaB-dependent gene expression was significantly reduced in cells receiving nanomolar concentrations of SWCNT-NF-kappaB decoys compared to cells receiving SWCNTs or SWCNTs functionalized with a nonspecific ODN sequence, demonstrating both efficacy and specificity of the approach. PMID:20411956

  19. Oxidized ultrashort nanotubes as carbon scaffolds for the construction of cell-penetrating NF-kappaB decoy molecules.

    PubMed

    Crinelli, Rita; Carloni, Elisa; Menotta, Michele; Giacomini, Elisa; Bianchi, Marzia; Ambrosi, Gianluca; Giorgi, Luca; Magnani, Mauro

    2010-05-25

    Oligonucleotide (ODN) decoys are synthetic ODNs containing the DNA binding sequence of a transcription factor. When delivered to cells, these molecules can compete with endogenous sequences for binding the transcription factor, thus inhibiting its ability to activate the expression of target genes. Modulation of gene expression by decoy ODNs against nuclear factor-kappaB (NF-kappaB), a transcription factor regulating many genes involved in immunity, has been achieved in a variety of immune/inflammatory disorders. However, the successful use of transcription factor decoys depends on an efficient means to bring the synthetic DNA to target cells. It is known that single-walled carbon nanotubes (SWCNTs), under certain conditions, are able to cross the cell membrane. Thus, we have evaluated the possibility to functionalize SWCNTs with decoy ODNs against NF-kappaB in order to improve their intracellular delivery. To couple ODNs to CNTs, we have exploited the carbodiimide chemistry which allows covalent binding of amino-modified ODNs to carboxyl groups introduced onto SWCNTs through oxidation. The effective binding of ODNs to nanotubes has been demonstrated by a combination of microscopic, spectroscopic, and electrophoretic techniques. The uptake and subcellular distribution of ODN decoys bound to SWCNTs was analyzed by fluorescence microscopy. ODNs were internalized into macrophages and accumulated in the cytosol. Moreover, no cytotoxicity associated with SWCNT administration was observed. Finally, NF-kappaB-dependent gene expression was significantly reduced in cells receiving nanomolar concentrations of SWCNT-NF-kappaB decoys compared to cells receiving SWCNTs or SWCNTs functionalized with a nonspecific ODN sequence, demonstrating both efficacy and specificity of the approach.

  20. DECOY: Documenting Experiences with Cigarettes and Other Tobacco in Young Adults

    PubMed Central

    Berg, Carla J.; Haardörfer, Regine; Lewis, Michael; Getachew, Betelihem; Lloyd, Steven A.; Thomas, Sarah Fretti; Lanier, Angela; Trepanier, Kelleigh; Johnston, Teresa; Grimsley, Linda; Foster, Bruce; Benson, Stephanie; Smith, Alicia; Barr, Dana Boyd; Windle, Michael

    2016-01-01

    Objectives We examined psychographic characteristics associated with tobacco use among Project DECOY participants. Methods Project DECOY is a 2-year longitudinal mixed-methods study examining risk for tobacco use among 3418 young adults across 7 Georgia colleges/universities. Baseline measures included sociodemographics, tobacco use, and psychographics using the Values, Attitudes, and Lifestyle Scale. Bivariate and multivariable analyses were conducted to identify correlates of tobacco use. Results Past 30-day use prevalence was: 13.3% cigarettes; 11.3% little cigars/cigarillos (LCCs); 3.6% smokeless tobacco; 10.9% e-cigarettes; and 12.2% hookah. Controlling for sociodemographics, correlates of cigarette use included greater novelty seeking (p < .001) and intellectual curiosity (p = .010) and less interest in tangible creation (p = .002) and social conservatism (p < .001). Correlates of LCC use included greater novelty seeking (p < .001) and greater fashion orientation (p = .007). Correlates of smokeless tobacco use included greater novelty seeking (p = .006) and less intellectual curiosity (p < .001). Correlates of e-cigarette use included greater novelty seeking (p < .001) and less social conservatism (p = .002). Correlates of hookah use included greater novelty seeking (p < .001), fashion orientation (p = .044), and self-focused thinking (p = .002), and less social conservatism (p < .001). Conclusions Psychographic characteristics distinguish users of different tobacco products. PMID:27103410

  1. Can a pairwise contact potential stabilize native protein folds against decoys obtained by threading?

    PubMed

    Vendruscolo, M; Najmanovich, R; Domany, E

    2000-02-01

    We present a method to derive contact energy parameters from large sets of proteins. The basic requirement on which our method is based is that for each protein in the database the native contact map has lower energy than all its decoy conformations that are obtained by threading. Only when this condition is satisfied one can use the proposed energy function for fold identification. Such a set of parameters can be found (by perceptron learning) if Mp, the number of proteins in the database, is not too large. Other aspects that influence the existence of such a solution are the exact definition of contact and the value of the critical distance Rc, below which two residues are considered to be in contact. Another important novel feature of our approach is its ability to determine whether an energy function of some suitable proposed form can or cannot be parameterized in a way that satisfies our basic requirement. As a demonstration of this, we determine the region in the (Rc, Mp) plane in which the problem is solvable, i.e., we can find a set of contact parameters that stabilize simultaneously all the native conformations. We show that for large enough databases the contact approximation to the energy cannot stabilize all the native folds even against the decoys obtained by gapless threading. PMID:10656261

  2. Diversity, decoys and the dilution effect: how ecological communities affect disease risk.

    PubMed

    Johnson, P T J; Thieltges, D W

    2010-03-15

    Growing interest in ecology has recently focused on the hypothesis that community diversity can mediate infection levels and disease ('dilution effect'). In turn, biodiversity loss--a widespread consequence of environmental change--can indirectly promote increases in disease, including those of medical and veterinary importance. While this work has focused primarily on correlational studies involving vector-borne microparasite diseases (e.g. Lyme disease, West Nile virus), we argue that parasites with complex life cycles (e.g. helminths, protists, myxosporeans and many fungi) offer an excellent additional model in which to experimentally address mechanistic questions underlying the dilution effect. Here, we unite recent ecological research on the dilution effect in microparasites with decades of parasitological research on the decoy effect in macroparasites to explore key questions surrounding the relationship between community structure and disease. We find consistent evidence that community diversity significantly alters parasite transmission and pathology under laboratory as well as natural conditions. Empirical examples and simple transmission models highlight the diversity of mechanisms through which such changes occur, typically involving predators, parasite decoys, low competency hosts or other parasites. However, the degree of transmission reduction varies among diluting species, parasite stage, and across spatial scales, challenging efforts to make quantitative, taxon-specific predictions about disease. Taken together, this synthesis highlights the broad link between community structure and disease while underscoring the importance of mitigating ongoing changes in biological communities owing to species introductions and extirpations.

  3. Managing MicroRNAs with Vector-Encoded Decoy-Type Inhibitors

    PubMed Central

    Bak, Rasmus O; Hollensen, Anne Kruse; Mikkelsen, Jacob Giehm

    2013-01-01

    A rapidly growing understanding of the complex circuitry of microRNA (miRNA)-mediated gene regulation is attracting attention to miRNAs as new drug targets. Targeted miRNA suppression is achieved in a sequence-specific manner by antisense RNA “decoy” molecules. Such synthetic miRNA inhibitors have reached the clinic with remarkable pace and may soon appear as new therapeutic modalities in several diseases. Shortcomings, however, include high production costs, the requirement for repeated administration, and difficulty achieving tissue-specific delivery. With the many recent landmark achievements in clinical gene therapy, new and refined vector-encoded miRNA suppression technologies are attractive for many applications, not least as tools in innumerable daily studies of miRNA biology in laboratories worldwide. Here, we provide an overview of the strategies that have been used to adapt vector-encoded inhibitors for miRNA suppression and discuss advantages related to spatiotemporal and long-term miRNA attenuation. With the remarkable new discovery of miRNA management by naturally occurring circular RNAs, RNA circles generated by trans-splicing mechanisms may prove to be well-suited carriers of decoy-type miRNA inhibitors. The community will aspire to combine circles with high-affinity miRNA decoy methodologies, and such “vectorized” RNA circles may represent new solid ways to deliver miRNA inhibitors, perhaps even with therapeutic applications. PMID:23752312

  4. Soluble Vascular Endothelial Growth Factor Decoy Receptor FP3 Exerts Potent Antiangiogenic Effects

    PubMed Central

    Yu, De-Chao; Lee, Jung-Sun; Yoo, Ji Young; Shin, Hyewon; Deng, Hongxin; Wei, Yuquan; Yun, Chae-Ok

    2012-01-01

    The binding of vascular endothelial growth factor (VEGF) to its receptors stimulates tumor growth; therefore, modulation of VEGF would be a viable approach for antiangiogenic therapy. We constructed a series of soluble decoy receptors containing different VEGF receptor 1 (FLT1) and VEGF receptor 2 (KDR) extracellular domains fused with the Fc region of human immunoglobulin (Ig) and evaluated their antiangiogenic effects and antitumor effects. Results of in vitro binding and cell proliferation assays revealed that decoy receptor FP3 had the highest affinity to VEGF-A and -B. Compared with bevacizumab, FP3 more effectively inhibited human umbilical vein endothelial cell (HUVEC) migration and vessel sprouting from rat aortic rings. FP3 significantly reduced phosphorylation of AKT and ERK1/2, critical proteins in the VEGF-mediated survival pathway in endothelial cells. Moreover, FP3 inhibited tumor growth in human hepatocellular carcinoma (HepG2), breast cancer (MCF-7), and colorectal cancer (LoVo) tumor models, and reduced microvessel density in tumor tissues. The FP3-mediated inhibition of tumor growth was significantly higher than that of bevacizumab at the same dose. FP3 also demonstrated synergistic antitumor effects when combined with 5-fluorouracil (5-FU). Taken together, FP3 shows a high affinity for VEGF and produced antiangiogenic effects, suggesting its potential for treating angiogenesis-related diseases such as cancer. PMID:22273580

  5. Long-distance measurement-device-independent multiparty quantum communication.

    PubMed

    Fu, Yao; Yin, Hua-Lei; Chen, Teng-Yun; Chen, Zeng-Bing

    2015-03-01

    The Greenberger-Horne-Zeilinger (GHZ) entanglement, originally introduced to uncover the extreme violation of local realism against quantum mechanics, is an important resource for multiparty quantum communication tasks. But the low intensity and fragility of the GHZ entanglement source in current conditions have made the practical applications of these multiparty tasks an experimental challenge. Here we propose a feasible scheme for practically distributing the postselected GHZ entanglement over a distance of more than 100 km for experimentally accessible parameter regimes. Combining the decoy-state and measurement-device-independent protocols for quantum key distribution, we anticipate that our proposal suggests an important avenue for practical multiparty quantum communication.

  6. Security proof of a three-state quantum-key-distribution protocol without rotational symmetry

    SciTech Connect

    Fung, C.-H.F.; Lo, H.-K.

    2006-10-15

    Standard security proofs of quantum-key-distribution (QKD) protocols often rely on symmetry arguments. In this paper, we prove the security of a three-state protocol that does not possess rotational symmetry. The three-state QKD protocol we consider involves three qubit states, where the first two states |0{sub z}> and |1{sub z}> can contribute to key generation, and the third state |+>=(|0{sub z}>+|1{sub z}>)/{radical}(2) is for channel estimation. This protocol has been proposed and implemented experimentally in some frequency-based QKD systems where the three states can be prepared easily. Thus, by founding on the security of this three-state protocol, we prove that these QKD schemes are, in fact, unconditionally secure against any attacks allowed by quantum mechanics. The main task in our proof is to upper bound the phase error rate of the qubits given the bit error rates observed. Unconditional security can then be proved not only for the ideal case of a single-photon source and perfect detectors, but also for the realistic case of a phase-randomized weak coherent light source and imperfect threshold detectors. Our result in the phase error rate upper bound is independent of the loss in the channel. Also, we compare the three-state protocol with the Bennett-Brassard 1984 (BB84) protocol. For the single-photon source case, our result proves that the BB84 protocol strictly tolerates a higher quantum bit error rate than the three-state protocol, while for the coherent-source case, the BB84 protocol achieves a higher key generation rate and secure distance than the three-state protocol when a decoy-state method is used.

  7. Position sensitive solid state detectors

    NASA Astrophysics Data System (ADS)

    Schnatterly, S. E.; Husk, D.

    1986-05-01

    Solid state detectors have been used for years as high quantum efficiency detectors for visible light. In this paper the use of PDA and CCD, solid state detectors, in the X-ray region will be discussed. In particular examples of data in the soft X-ray region are presented. Finally the use of phosphor coatings to enhance the sensitivity of solid state detectors is described.

  8. Discriminating of ATP competitive Src kinase inhibitors and decoys using self-organizing map and support vector machine.

    PubMed

    Yan, Aixia; Hu, Xiaoying; Wang, Kai; Sun, Jing

    2013-02-01

    A data set containing 686 Src kinase inhibitors and 1,941 Src kinase non-binding decoys was collected and used to build two classification models to distinguish inhibitors from decoys. The data set was randomly split into a training set (458 inhibitors and 972 decoys) and a test set (228 inhibitors and 969 decoys). Each molecule was represented by five global molecular descriptors and 18 2D property autocorrelation descriptors calculated using the program ADRIANA.Code. Two machine learning methods, a Kohonen's self-organizing map (SOM) and a support vector machine (SVM), were utilized for the training and classification. For the test set, classification accuracy (ACC) of 99.92% and Matthews correlation coefficient (MCC) of 0.98 were achieved for the SOM model; ACC of 99.33% and MCC of 0.98 were obtained for the SVM model. Some molecular properties, such as molecular weight, number of atoms in a molecule, hydrogen bond properties, polarizabilities, electronegativities, and hydrophobicities, were found to be important for the inhibition of Src kinase.

  9. Immunomodulation of cystic fibrosis epithelial cells via NF-κB decoy oligonucleotide-coated polysaccharide nanoparticles.

    PubMed

    Wardwell, Patricia R; Bader, Rebecca A

    2015-05-01

    Activation of the transcription factor nuclear factor-kappa B (NF-κB) signaling pathway is associated with enhanced secretion of pro-inflammatory mediators and is thought to play a critical role in diseases hallmarked by inflammation, including cystic fibrosis (CF). Small nucleic acids that interfere with gene expression have been proposed as promising therapeutics for a number of diseases. However, applications have been limited by low cellular penetration and a lack of stability. Nano-sized carrier systems have been suggested as a means of improving the effectiveness of nucleic acid-based treatments. In this study, we successfully coated polysialic acid-N-trimethyl chitosan (PSA-TMC) nanoparticles with NF-κΒ decoy oligonucleotides (ODNs). To demonstrate anti-inflammatory activity, the decoy ODN-coated PSA-TMC nanoparticles were administered to an in vitro model of CF generated via interleukin-1β or P. aeruginosa lipopolysaccharides stimulation of IB3-1 bronchial epithelial cells. While free ODN and PSA-TMC nanoparticles coated with scrambled ODNs did not have substantial impacts on the inflammatory response, the decoy ODN-coated PSA-TMC nanoparticles were able to reduce the secretion of interleukin-6 and interleukin-8, pro-inflammatory mediators of CF, by the epithelial cells, particularly at longer time points. In general, the results suggest that NF-κB decoy ODN-coated TMC-PSA nanoparticles may serve as an effective method of altering the pro-inflammatory environment associated with CF.

  10. Derivation of the sensitivity of a Geiger mode avalanche photodiode detector from a given efficiency for quantum key distribution experiments

    NASA Astrophysics Data System (ADS)

    Hammura, Kiyotaka; Williams, David

    2009-05-01

    The detection sensitivity (DS) of a commercial single-photon receiver based on an InGaAs gate-mode avalanche photodiode is estimated. The installation of a digital-blanking system (DBS) to reduce dark current differentiates between the DS, which is the efficiency of the detector during its open-gate/active state, and the total/overall detection efficiency (DE). Using numerical simulations it is found that the average number of light-pulses blanked by DBS following a registered pulse is 0.333. The DS is estimated at 0.216, which can be used for estimating the DE for an arbitrary photon arrival rate and gating frequency of the receiver.

  11. Wearable and sensitive heart-rate detectors based on PbS quantum dot and multiwalled carbon nanotube blend film

    NASA Astrophysics Data System (ADS)

    Gao, Liang; Dong, Dongdong; He, Jungang; Qiao, Keke; Cao, Furong; Li, Min; Liu, Huan; Cheng, Yibing; Tang, Jiang; Song, Haisheng

    2014-10-01

    Wearable and sensitive photodetectors (PDs) have been demonstrated based on a blend film of PbS quantum dots (QDs) and QDs modified multiwalled carbon nanotubes (MWCNTs). Owing to the synergetic effect from high light sensitivity of PbS QDs and excellent conductive and mechanical properties of MWCNTs, the blend PDs show high sensitivity and flexibility performance: device responsivity and detectivity reach 583 mA/W and 3.25 × 1012 Jones, respectively, and could stand large number (at least 10 000 cycles) and wide angle (up to 80°) bending. Furthermore, the wearable and sensitive PDs have been applied to measure the heart rate in both red and near infrared (NIR) ranges. The presented PDs are expected to work as sensor candidates in integrated electronic skin.

  12. Wearable and sensitive heart-rate detectors based on PbS quantum dot and multiwalled carbon nanotube blend film

    SciTech Connect

    Gao, Liang; Dong, Dongdong; Qiao, Keke; Cheng, Yibing; Tang, Jiang E-mail: songhs-wnlo@mail.hust.edu.cn; Song, Haisheng E-mail: songhs-wnlo@mail.hust.edu.cn; He, Jungang; Li, Min; Liu, Huan; Cao, Furong

    2014-10-13

    Wearable and sensitive photodetectors (PDs) have been demonstrated based on a blend film of PbS quantum dots (QDs) and QDs modified multiwalled carbon nanotubes (MWCNTs). Owing to the synergetic effect from high light sensitivity of PbS QDs and excellent conductive and mechanical properties of MWCNTs, the blend PDs show high sensitivity and flexibility performance: device responsivity and detectivity reach 583 mA/W and 3.25 × 10{sup 12 }Jones, respectively, and could stand large number (at least 10 000 cycles) and wide angle (up to 80°) bending. Furthermore, the wearable and sensitive PDs have been applied to measure the heart rate in both red and near infrared (NIR) ranges. The presented PDs are expected to work as sensor candidates in integrated electronic skin.

  13. Compact, rapid, and rugged detector of military and improvised explosives based on external grating cavity quantum cascade lasers

    NASA Astrophysics Data System (ADS)

    Tsekoun, Alexei; Dunayevskiy, Ilya; Maulini, Richard; Barron-Jimenez, Rodolfo; Lyakh, Arkadiy; Patel, C. Kumar N.

    2009-08-01

    Early detection of explosive substances is the first and most difficult step in defeating explosive devices. Many currently available methods suffer from fundamental failure modes limiting their realworld suitability. Infrared spectroscopy is ideal for reliable identification of explosives since it probes the chemical composition of molecules. Quantum cascade lasers rapidly became the light source of choice of IR spectroscopy due to their wavelength agility, relatively high output power, and small size and weight. Our compact, rapid, and rugged multi-explosives sensor based on external grating cavity QCLs simultaneously detects TNT, TATP, and acetone while being immune to ammonium nitrate interference. The instrument features low false alarm rate, and low probability of false negatives. Receiver operation characteristics curves are presented.

  14. New glycoproteomics software, GlycoPep Evaluator, generates decoy glycopeptides de novo and enables accurate false discovery rate analysis for small data sets.

    PubMed

    Zhu, Zhikai; Su, Xiaomeng; Go, Eden P; Desaire, Heather

    2014-09-16

    Glycoproteins are biologically significant large molecules that participate in numerous cellular activities. In order to obtain site-specific protein glycosylation information, intact glycopeptides, with the glycan attached to the peptide sequence, are characterized by tandem mass spectrometry (MS/MS) methods such as collision-induced dissociation (CID) and electron transfer dissociation (ETD). While several emerging automated tools are developed, no consensus is present in the field about the best way to determine the reliability of the tools and/or provide the false discovery rate (FDR). A common approach to calculate FDRs for glycopeptide analysis, adopted from the target-decoy strategy in proteomics, employs a decoy database that is created based on the target protein sequence database. Nonetheless, this approach is not optimal in measuring the confidence of N-linked glycopeptide matches, because the glycopeptide data set is considerably smaller compared to that of peptides, and the requirement of a consensus sequence for N-glycosylation further limits the number of possible decoy glycopeptides tested in a database search. To address the need to accurately determine FDRs for automated glycopeptide assignments, we developed GlycoPep Evaluator (GPE), a tool that helps to measure FDRs in identifying glycopeptides without using a decoy database. GPE generates decoy glycopeptides de novo for every target glycopeptide, in a 1:20 target-to-decoy ratio. The decoys, along with target glycopeptides, are scored against the ETD data, from which FDRs can be calculated accurately based on the number of decoy matches and the ratio of the number of targets to decoys, for small data sets. GPE is freely accessible for download and can work with any search engine that interprets ETD data of N-linked glycopeptides. The software is provided at https://desairegroup.ku.edu/research.

  15. Plant targets for Pseudomonas syringae type III effectors: virulence targets or guarded decoys?

    PubMed

    Block, Anna; Alfano, James R

    2011-02-01

    The phytopathogenic bacterium Pseudomonas syringae can suppress both pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) by the injection of type III effector (T3E) proteins into host cells. T3Es achieve immune suppression using a variety of strategies including interference with immune receptor signaling, blocking RNA pathways and vesicle trafficking, and altering organelle function. T3Es can be recognized indirectly by resistance proteins monitoring specific T3E targets resulting in ETI. It is presently unclear whether the monitored targets represent bona fide virulence targets or guarded decoys. Extensive overlap between PTI and ETI signaling suggests that T3Es may suppress both pathways through common targets and by possessing multiple activities. PMID:21227738

  16. Sharks shape the geometry of a selfish seal herd: experimental evidence from seal decoys.

    PubMed

    De Vos, Alta; O'Riain, M Justin

    2010-02-23

    Many animals respond to predation risk by forming groups. Evolutionary explanations for group formation in previously ungrouped, but loosely associated prey have typically evoked the selfish herd hypothesis. However, despite over 600 studies across a diverse array of taxa, the critical assumptions of this hypothesis have remained collectively untested, owing to several confounding problems in real predator-prey systems. To solve this, we manipulated the domains of danger of Cape fur seal (Arctocephalus pusillus pusillus) decoys to provide evidence that a selfish reduction in a seals' domain of danger results in a proportional reduction in its predation risk from ambush shark attacks. This behaviour confers a survival advantage to individual seals within a group and explains the evolution of selfish herds in a prey species. These findings empirically elevate Hamilton's selfish herd hypothesis to more than a 'theoretical curiosity'.

  17. Sharks shape the geometry of a selfish seal herd: experimental evidence from seal decoys

    PubMed Central

    De Vos, Alta; O'Riain, M. Justin

    2010-01-01

    Many animals respond to predation risk by forming groups. Evolutionary explanations for group formation in previously ungrouped, but loosely associated prey have typically evoked the selfish herd hypothesis. However, despite over 600 studies across a diverse array of taxa, the critical assumptions of this hypothesis have remained collectively untested, owing to several confounding problems in real predator–prey systems. To solve this, we manipulated the domains of danger of Cape fur seal (Arctocephalus pusillus pusillus) decoys to provide evidence that a selfish reduction in a seals' domain of danger results in a proportional reduction in its predation risk from ambush shark attacks. This behaviour confers a survival advantage to individual seals within a group and explains the evolution of selfish herds in a prey species. These findings empirically elevate Hamilton's selfish herd hypothesis to more than a ‘theoretical curiosity’. PMID:19793737

  18. Intrinsic quantum correlations of weak coherent states for quantum communication

    SciTech Connect

    Sua Yongmeng; Scanlon, Erin; Beaulieu, Travis; Bollen, Viktor; Lee, Kim Fook

    2011-03-15

    Intrinsic quantum correlations of weak coherent states are observed between two parties through a novel detection scheme, which can be used as a supplement to the existence decoy-state Bennett-Brassard 1984 protocol and the differential phase-shift quantum key distribution (DPS-QKD) protocol. In a proof-of-principle experiment, we generate bipartite correlations of weak coherent states using weak local oscillator fields in two spatially separated balanced homodyne detections. We employ a nonlinearity of postmeasurement method to obtain the bipartite correlations from two single-field interferences at individual homodyne measurements. This scheme is then used to demonstrate bits correlations between two parties over a distance of 10 km through a transmission fiber. We believe that the scheme can add another physical layer of security to these protocols for quantum key distribution.

  19. Investigations of quantum efficiency in type-II InAs/GaSb very long wavelength infrared superlattice detectors

    NASA Astrophysics Data System (ADS)

    Li, Xiaochao; Jiang, Dongwei; Zhang, Yong; Liu, Gang; Wang, Dongbo; Yu, Qingjiang; Zhao, Liancheng

    2016-04-01

    In this paper, we have investigated the quantum efficiency (QE) of InAs/GaSb T2SL very long wavelength Infrared (VLWIR) photodetectors with 50% cutoff of 12.7 μm. Due to the small depletion width and similar absorption coefficient in the T2SL material system, the minority-carrier diffusion length was determined as the key element to improve the QE of VLWIR T2SL photodetectors. The minority-carrier diffusion length was estimated by a comparison of the experimental data with the Hovel model. Our result suggest that the short hole diffusion length (Lh ∼ 520 nm) and the large its ratio to the width of this region (xn/Lh) are considered against the photo-excited carrier collection in the T2SL photodetectors. In addition, the influence of surface recombination velocity (Sh) on the QE of the T2SL photodetectors is also studied. The change of QE with Sh is not so significant due to the relatively low absorption coefficient and short hole diffusion length in our photodetector.

  20. Security of quantum key distribution using a simplified trusted relay

    NASA Astrophysics Data System (ADS)

    Stacey, William; Annabestani, Razieh; Ma, Xiongfeng; Lütkenhaus, Norbert

    2015-01-01

    We propose a QKD protocol for trusted node relays. Our protocol shifts the communication and computational weight of classical postprocessing to the end users by reassigning the roles of error correction and privacy amplification, while leaving the exchange of quantum signals untouched. We perform a security analysis for this protocol based on the Bennett-Brassard 1984 protocol on the level of infinite key formulas, taking into account weak coherent implementations involving decoy analysis.

  1. GENERAL: Efficient quantum secure communication with a publicly known key

    NASA Astrophysics Data System (ADS)

    Li, Chun-Yan; Li, Xi-Han; Deng, Fu-Guo; Zhou, Hong-Yu

    2008-07-01

    This paper presents a simple way for an eavesdropper to eavesdrop freely the secret message in the experimental realization of quantum communication protocol proposed by Beige et al (2002 Acta Phys. Pol. A 101 357). Moreover, it introduces an efficient quantum secure communication protocol based on a publicly known key with decoy photons and two biased bases by modifying the original protocol. The total efficiency of this new protocol is double that of the original one. With a low noise quantum channel, this protocol can be used for transmitting a secret message. At present, this protocol is good for generating a private key efficiently.

  2. Quantum memory Quantum memory

    NASA Astrophysics Data System (ADS)

    Le Gouët, Jean-Louis; Moiseev, Sergey

    2012-06-01

    quest for higher efficiency, better fidelity, broader bandwidth, multimode capacity and longer storage lifetime is pursued in all those approaches, as shown in this special issue. The improvement of quantum memory operation specifically requires in-depth study and control of numerous physical processes leading to atomic decoherence. The present issue reflects the development of rare earth ion doped matrices offering long lifetime superposition states, either as bulk crystals or as optical waveguides. The need for quantum sources and high efficiency detectors at the single photon level is also illustrated. Several papers address the networking of quantum memories either in long-haul cryptography or in the prospect of quantum processing. In this context, much attention has been paid recently to interfacing quantum light with superconducting qubits and with nitrogen-vacancy centers in diamond. Finally, the quantum interfacing of light with matter raises questions on entanglement. The last two papers are devoted to the generation of entanglement by dissipative processes. It is shown that long lifetime entanglement may be built in this way. We hope this special issue will help readers to become familiar with the exciting field of ensemble-based quantum memories and will stimulate them to bring deeper insights and new ideas to this area.

  3. Detective quantum efficiency for photon-counting hybrid pixel detectors in the tender X-ray domain: application to Medipix3RX.

    PubMed

    Rinkel, Jean; Magalhães, Debora; Wagner, Franz; Meneau, Florian; Cesar Vicentin, Flavio

    2016-01-01

    Synchrotron-radiation-based X-ray imaging techniques using tender X-rays are facing a growing demand, in particular to probe the K absorption edges of low-Z elements. Here, a mathematical model has been developed for estimating the detective quantum efficiency (DQE) at zero spatial frequency in the tender X-ray energy range for photon-counting detectors by taking into account the influence of electronic noise. The experiments were carried out with a Medipix3RX ASIC bump-bonded to a 300 µm silicon sensor at the Soft X-ray Spectroscopy beamline (D04A-SXS) of the Brazilian Synchrotron Light Laboratory (LNLS, Campinas, Brazil). The results show that Medipix3RX can be used to develop new imaging modalities in the tender X-ray range for energies down to 2 keV. The efficiency and optimal DQE depend on the energy and flux of the photons. The optimal DQE values were found in the 7.9-8.6 keV photon energy range. The DQE deterioration for higher energies due to the lower absorption efficiency of the sensor and for lower energies due to the electronic noise has been quantified. The DQE for 3 keV photons and 1 × 10(4) photons pixel(-1) s(-1) is similar to that obtained with 19 keV photons. Based on our model, the use of Medipix3RX could be extended down to 2 keV which is crucial for coming applications in imaging techniques at modern synchrotron sources. PMID:26698065

  4. Discriminating the native structure from decoys using scoring functions based on the residue packing in globular proteins

    PubMed Central

    2009-01-01

    Background Setting the rules for the identification of a stable conformation of a protein is of utmost importance for the efficient generation of structures in computer simulation. For structure prediction, a considerable number of possible models are generated from which the best model has to be selected. Results Two scoring functions, Rs and Rp, based on the consideration of packing of residues, which indicate if the conformation of an amino acid sequence is native-like, are presented. These are defined using the solvent accessible surface area (ASA) and the partner number (PN) (other residues that are within 4.5 Å) of a particular residue. The two functions evaluate the deviation from the average packing properties (ASA or PN) of all residues in a polypeptide chain corresponding to a model of its three-dimensional structure. While simple in concept and computationally less intensive, both the functions are at least as efficient as any other energy functions in discriminating the native structure from decoys in a large number of standard decoy sets, as well as on models submitted for the targets of CASP7. Rs appears to be slightly more effective than Rp, as determined by the number of times the native structure possesses the minimum value for the function and its separation from the average value for the decoys. Conclusion Two parameters, Rs and Rp, are discussed that can very efficiently recognize the native fold for a sequence from an ensemble of decoy structures. Unlike many other algorithms that rely on the use of composite scoring function, these are based on a single parameter, viz., the accessible surface area (or the number of residues in contact), but still able to capture the essential attribute of the native fold. PMID:20038291

  5. Entanglement-Based Quantum Cryptography and Quantum Communication

    NASA Astrophysics Data System (ADS)

    Zeilinger, Anton

    2007-03-01

    Quantum entanglement, to Erwin Schroedinger the essential feature of quantum mechanics, has become a central resource in various quantum communication protocols including quantum cryptography and quantum teleportation. From a fundamental point of view what is exploited in these experiments is the very fact which led Schroedinger to his statement namely that in entangled states joint properties of the entangled systems may be well defined while the individual subsystems may carry no information at all. In entanglement-based quantum cryptography it leads to the most elegant possible solution of the classic key distribution problem. It implies that the key comes into existence at spatially distant location at the same time and does not need to be transported. A number recent developments include for example highly efficient, robust and stable sources of entangled photons with a broad bandwidth of desired features. Also, entanglement-based quantum cryptography is successfully joining other methods in the work towards demonstrating quantum key distribution networks. Along that line recently decoy-state quantum cryptography over a distance of 144 km between two Canary Islands was demonstrated successfully. Such experiments also open up the possibility of quantum communication on a really large scale using LEO satellites. Another important possible future branch of quantum communication involves quantum repeaters in order to cover larger distances with entangled states. Recently the connection of two fully independent lasers in an entanglement swapping experiment did demonstrate that the timing control of such systems on a femtosecond time scale is possible. A related development includes recent demonstrations of all-optical one-way quantum computation schemes with the extremely short cycle time of only 100 nanoseconds.

  6. Search for quantum black hole production in high-invariant-mass lepton+jet final states using pp collisions at √s=8  TeV and the ATLAS detector.

    PubMed

    Aad, G; Abajyan, T; Abbott, B; Abdallah, J; Abdel Khalek, S; Abdinov, O; Aben, R; Abi, B; Abolins, M; Abouzeid, O S; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, B S; Adamczyk, L; Adams, D L; Addy, T N; Adelman, J; Adomeit, S; Adye, T; Aefsky, S; Agatonovic-Jovin, T; Aguilar-Saavedra, J A; Agustoni, M; Ahlen, S P; Ahmad, A; Ahmadov, F; Aielli, G; Akesson, T P A; Akimoto, G; Akimov, A V; Alam, M A; Albert, J; Albrand, S; Alconada Verzini, M J; Aleksa, M; Aleksandrov, I N; Alexa, C; Alexander, G; Alexandre, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Allbrooke, B M M; Allison, L J; Allport, P P; Allwood-Spiers, S E; Almond, J; Aloisio, A; Alon, R; Alonso, A; Alonso, F; Altheimer, A; Alvarez Gonzalez, B; Alviggi, M G; Amako, K; Amaral Coutinho, Y; Amelung, C; Ammosov, V V; Amor Dos Santos, S P; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, L S; Andari, N; Andeen, T; Anders, C F; Anders, G; Anderson, K J; Andreazza, A; Andrei, V; Anduaga, X S; Angelidakis, S; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, A V; Anjos, N; Annovi, A; Antonaki, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Aperio Bella, L; Apolle, R; Arabidze, G; Aracena, I; Arai, Y; Arce, A T H; Arguin, J-F; Argyropoulos, S; Arik, E; Arik, M; Armbruster, A J; Arnaez, O; Arnal, V; Arslan, O; Artamonov, A; Artoni, G; Asai, S; Asbah, N; Ask, S; Asman, B; Asquith, L; Assamagan, K; Astalos, R; Astbury, A; Atkinson, M; Atlay, N B; Auerbach, B; Auge, E; Augsten, K; Aurousseau, M; Avolio, G; Azuelos, G; Azuma, Y; Baak, M A; Bacci, C; Bach, A M; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Backus Mayes, J; Badescu, E; Bagiacchi, P; Bagnaia, P; Bai, Y; Bailey, D C; Bain, T; Baines, J T; Baker, O K; Baker, S; Balek, P; Balli, F; Banas, E; Banerjee, Sw; Banfi, D; Bangert, A; Bansal, V; Bansil, H S; Barak, L; Baranov, S P; Barber, T; Barberio, E L; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnett, B M; Barnett, R M; Baroncelli, A; Barone, G; Barr, A J; Barreiro, F; Barreiro Guimarães da Costa, J; Bartoldus, R; Barton, A E; Bartos, P; Bartsch, V; Bassalat, A; Basye, A; Bates, R L; Batkova, L; Batley, J R; Battistin, M; Bauer, F; Bawa, H S; Beau, T; Beauchemin, P H; Beccherle, R; Bechtle, P; Beck, H P; Becker, K; Becker, S; Beckingham, M; Beddall, A J; Beddall, A; Bedikian, S; Bednyakov, V A; Bee, C P; Beemster, L J; Beermann, T A; Begel, M; Behr, K; Belanger-Champagne, C; Bell, P J; Bell, W H; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belloni, A; Beloborodova, O L; Belotskiy, K; Beltramello, O; Benary, O; Benchekroun, D; Bendtz, K; Benekos, N; Benhammou, Y; Benhar Noccioli, E; Benitez Garcia, J A; Benjamin, D P; Bensinger, J R; Benslama, K; Bentvelsen, S; Berge, D; Bergeaas Kuutmann, E; Berger, N; Berghaus, F; Berglund, E; Beringer, J; Bernard, C; Bernat, P; Bernius, C; Bernlochner, F U; Berry, T; Berta, P; Bertella, C; Bertolucci, F; Besana, M I; Besjes, G J; Bessidskaia, O; Besson, N; Bethke, S; Bhimji, W; Bianchi, R M; Bianchini, L; Bianco, M; Biebel, O; Bieniek, S P; Bierwagen, K; Biesiada, J; Biglietti, M; Bilbao De Mendizabal, J; Bilokon, H; Bindi, M; Binet, S; Bingul, A; Bini, C; Bittner, B; Black, C W; Black, J E; Black, K M; Blackburn, D; Blair, R E; Blanchard, J-B; Blazek, T; Bloch, I; Blocker, C; Blum, W; Blumenschein, U; Bobbink, G J; Bobrovnikov, V S; Bocchetta, S S; Bocci, A; Boddy, C R; Boehler, M; Boek, J; Boek, T T; Bogaerts, J A; Bogdanchikov, A G; Bogouch, A; Bohm, C; Bohm, J; Boisvert, V; Bold, T; Boldea, V; Boldyrev, A S; Bolnet, N M; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Borri, M; Borroni, S; Bortfeldt, J; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Boterenbrood, H; Bouchami, J; Boudreau, J; Bouhova-Thacker, E V; Boumediene, D; Bourdarios, C; Bousson, N; Boutouil, S; Boveia, A; Boyd, J; Boyko, I R; Bozovic-Jelisavcic, I; Bracinik, J; Branchini, P; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, J E; Braun, H M; Brazzale, S F; Brelier, B; Brendlinger, K; Brennan, A J; Brenner, R; Bressler, S; Bristow, K; Bristow, T M; Britton, D; Brochu, F M; Brock, I; Brock, R; Bromberg, C; Bronner, J; Brooijmans, G; Brooks, T; Brooks, W K; Brosamer, J; Brost, E; Brown, G; Brown, J; Bruckman de Renstrom, P A; Bruncko, D; Bruneliere, R; Brunet, S; Bruni, A; Bruni, G; Bruschi, M; Bryngemark, L; Buanes, T; Buat, Q; Bucci, F; Buchholz, P; Buckingham, R M; Buckley, A G; Buda, S I; Budagov, I A; Budick, B; Buehrer, F; Bugge, L; Bugge, M K; Bulekov, O; Bundock, A C; Bunse, M; Burckhart, H; Burdin, S; Burghgrave, B; Burke, S; Burmeister, I; Busato, E; Büscher, V; Bussey, P; Buszello, C P; Butler, B; Butler, J M; Butt, A I; Buttar, C M; Butterworth, J M; Buttinger, W; Buzatu, A; Byszewski, M; Cabrera Urbán, S; Caforio, D; Cakir, O; Calafiura, P; Calderini, G; Calfayan, P

    2014-03-01

    This Letter presents a search for quantum black-hole production using 20.3 fb-1 of data collected with the ATLAS detector in pp collisions at the LHC at √s = 8 TeV. The quantum black holes are assumed to decay into a final state characterized by a lepton (electron or muon) and a jet. In either channel, no event with a lepton-jet invariant mass of 3.5 TeV or more is observed, consistent with the expected background. Limits are set on the product of cross sections and branching fractions for the lepton+jet final states of quantum black holes produced in a search region for invariant masses above 1 TeV. The combined 95% confidence level upper limit on this product for quantum black holes with threshold mass above 3.5 TeV is 0.18 fb. This limit constrains the threshold quantum black-hole mass to be above 5.3 TeV in the model considered. PMID:24655244

  7. Search for quantum black hole production in high-invariant-mass lepton+jet final states using pp collisions at √s=8  TeV and the ATLAS detector.

    PubMed

    Aad, G; Abajyan, T; Abbott, B; Abdallah, J; Abdel Khalek, S; Abdinov, O; Aben, R; Abi, B; Abolins, M; Abouzeid, O S; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, B S; Adamczyk, L; Adams, D L; Addy, T N; Adelman, J; Adomeit, S; Adye, T; Aefsky, S; Agatonovic-Jovin, T; Aguilar-Saavedra, J A; Agustoni, M; Ahlen, S P; Ahmad, A; Ahmadov, F; Aielli, G; Akesson, T P A; Akimoto, G; Akimov, A V; Alam, M A; Albert, J; Albrand, S; Alconada Verzini, M J; Aleksa, M; Aleksandrov, I N; Alexa, C; Alexander, G; Alexandre, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Allbrooke, B M M; Allison, L J; Allport, P P; Allwood-Spiers, S E; Almond, J; Aloisio, A; Alon, R; Alonso, A; Alonso, F; Altheimer, A; Alvarez Gonzalez, B; Alviggi, M G; Amako, K; Amaral Coutinho, Y; Amelung, C; Ammosov, V V; Amor Dos Santos, S P; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, L S; Andari, N; Andeen, T; Anders, C F; Anders, G; Anderson, K J; Andreazza, A; Andrei, V; Anduaga, X S; Angelidakis, S; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, A V; Anjos, N; Annovi, A; Antonaki, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Aperio Bella, L; Apolle, R; Arabidze, G; Aracena, I; Arai, Y; Arce, A T H; Arguin, J-F; Argyropoulos, S; Arik, E; Arik, M; Armbruster, A J; Arnaez, O; Arnal, V; Arslan, O; Artamonov, A; Artoni, G; Asai, S; Asbah, N; Ask, S; Asman, B; Asquith, L; Assamagan, K; Astalos, R; Astbury, A; Atkinson, M; Atlay, N B; Auerbach, B; Auge, E; Augsten, K; Aurousseau, M; Avolio, G; Azuelos, G; Azuma, Y; Baak, M A; Bacci, C; Bach, A M; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Backus Mayes, J; Badescu, E; Bagiacchi, P; Bagnaia, P; Bai, Y; Bailey, D C; Bain, T; Baines, J T; Baker, O K; Baker, S; Balek, P; Balli, F; Banas, E; Banerjee, Sw; Banfi, D; Bangert, A; Bansal, V; Bansil, H S; Barak, L; Baranov, S P; Barber, T; Barberio, E L; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnett, B M; Barnett, R M; Baroncelli, A; Barone, G; Barr, A J; Barreiro, F; Barreiro Guimarães da Costa, J; Bartoldus, R; Barton, A E; Bartos, P; Bartsch, V; Bassalat, A; Basye, A; Bates, R L; Batkova, L; Batley, J R; Battistin, M; Bauer, F; Bawa, H S; Beau, T; Beauchemin, P H; Beccherle, R; Bechtle, P; Beck, H P; Becker, K; Becker, S; Beckingham, M; Beddall, A J; Beddall, A; Bedikian, S; Bednyakov, V A; Bee, C P; Beemster, L J; Beermann, T A; Begel, M; Behr, K; Belanger-Champagne, C; Bell, P J; Bell, W H; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belloni, A; Beloborodova, O L; Belotskiy, K; Beltramello, O; Benary, O; Benchekroun, D; Bendtz, K; Benekos, N; Benhammou, Y; Benhar Noccioli, E; Benitez Garcia, J A; Benjamin, D P; Bensinger, J R; Benslama, K; Bentvelsen, S; Berge, D; Bergeaas Kuutmann, E; Berger, N; Berghaus, F; Berglund, E; Beringer, J; Bernard, C; Bernat, P; Bernius, C; Bernlochner, F U; Berry, T; Berta, P; Bertella, C; Bertolucci, F; Besana, M I; Besjes, G J; Bessidskaia, O; Besson, N; Bethke, S; Bhimji, W; Bianchi, R M; Bianchini, L; Bianco, M; Biebel, O; Bieniek, S P; Bierwagen, K; Biesiada, J; Biglietti, M; Bilbao De Mendizabal, J; Bilokon, H; Bindi, M; Binet, S; Bingul, A; Bini, C; Bittner, B; Black, C W; Black, J E; Black, K M; Blackburn, D; Blair, R E; Blanchard, J-B; Blazek, T; Bloch, I; Blocker, C; Blum, W; Blumenschein, U; Bobbink, G J; Bobrovnikov, V S; Bocchetta, S S; Bocci, A; Boddy, C R; Boehler, M; Boek, J; Boek, T T; Bogaerts, J A; Bogdanchikov, A G; Bogouch, A; Bohm, C; Bohm, J; Boisvert, V; Bold, T; Boldea, V; Boldyrev, A S; Bolnet, N M; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Borri, M; Borroni, S; Bortfeldt, J; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Boterenbrood, H; Bouchami, J; Boudreau, J; Bouhova-Thacker, E V; Boumediene, D; Bourdarios, C; Bousson, N; Boutouil, S; Boveia, A; Boyd, J; Boyko, I R; Bozovic-Jelisavcic, I; Bracinik, J; Branchini, P; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, J E; Braun, H M; Brazzale, S F; Brelier, B; Brendlinger, K; Brennan, A J; Brenner, R; Bressler, S; Bristow, K; Bristow, T M; Britton, D; Brochu, F M; Brock, I; Brock, R; Bromberg, C; Bronner, J; Brooijmans, G; Brooks, T; Brooks, W K; Brosamer, J; Brost, E; Brown, G; Brown, J; Bruckman de Renstrom, P A; Bruncko, D; Bruneliere, R; Brunet, S; Bruni, A; Bruni, G; Bruschi, M; Bryngemark, L; Buanes, T; Buat, Q; Bucci, F; Buchholz, P; Buckingham, R M; Buckley, A G; Buda, S I; Budagov, I A; Budick, B; Buehrer, F; Bugge, L; Bugge, M K; Bulekov, O; Bundock, A C; Bunse, M; Burckhart, H; Burdin, S; Burghgrave, B; Burke, S; Burmeister, I; Busato, E; Büscher, V; Bussey, P; Buszello, C P; Butler, B; Butler, J M; Butt, A I; Buttar, C M; Butterworth, J M; Buttinger, W; Buzatu, A; Byszewski, M; Cabrera Urbán, S; Caforio, D; Cakir, O; Calafiura, P; Calderini, G; Calfayan, P; Calkins, R; Caloba, L P; Caloi, R; Calvet, D; Calvet, S; Camacho Toro, R; Camarri, P; Cameron, D; Caminada, L M; Caminal Armadans, R; Campana, S; Campanelli, M; Campoverde, A; Canale, V; Canelli, F; Canepa, A; Cantero, J; Cantrill, R; Cao, T; Capeans Garrido, M D M; Caprini, I; Caprini, M; Capua, M; Caputo, R; Cardarelli, R; Carli, T; Carlino, G; Carminati, L; Caron, S; Carquin, E; Carrillo-Montoya, G D; Carter, A A; Carter, J R; Carvalho, J; Casadei, D; Casado, M P; Castaneda-Miranda, E; Castelli, A; Castillo Gimenez, V; Castro, N F; Catastini, P; Catinaccio, A; Catmore, J R; Cattai, A; Cattani, G; Caughron, S; Cavaliere, V; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Ceradini, F; Cerio, B; Cerny, K; Cerqueira, A S; Cerri, A; Cerrito, L; Cerutti, F; Cerv, M; Cervelli, A; Cetin, S A; Chafaq, A; Chakraborty, D; Chalupkova, I; Chan, K; Chang, P; Chapleau, B; Chapman, J D; Charfeddine, D; Charlton, D G; Chavda, V; Chavez Barajas, C A; Cheatham, S; Chekanov, S; Chekulaev, S V; Chelkov, G A; Chelstowska, M A; Chen, C; Chen, H; Chen, K; Chen, L; Chen, S; Chen, X; Chen, Y; Cheng, H C; Cheng, Y; Cheplakov, A; Cherkaoui El Moursli, R; Chernyatin, V; Cheu, E; Chevalier, L; Chiarella, V; Chiefari, G; Childers, J T; Chilingarov, A; Chiodini, G; Chisholm, A S; Chislett, R T; Chitan, A; Chizhov, M V; Chouridou, S; Chow, B K B; Christidi, I A; Chromek-Burckhart, D; Chu, M L; Chudoba, J; Ciapetti, G; Ciftci, A K; Ciftci, R; Cinca, D; Cindro, V; Ciocio, A; Cirkovic, P; Citron, Z H; Citterio, M; Ciubancan, M; Clark, A; Clark, P J; Clarke, R N; Cleland, W; Clemens, J C; Clement, B; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Coffey, L; Cogan, J G; Coggeshall, J; Cole, B; Cole, S; Colijn, A P; Collins-Tooth, C; Collot, J; Colombo, T; Colon, G; Compostella, G; Conde Muiño, P; Coniavitis, E; Conidi, M C; Connelly, I A; Consonni, S M; Consorti, V; Constantinescu, S; Conta, C; Conti, G; Conventi, F; Cooke, M; Cooper, B D; Cooper-Sarkar, A M; Cooper-Smith, N J; Copic, K; Cornelissen, T; Corradi, M; Corriveau, F; Corso-Radu, A; Cortes-Gonzalez, A; Cortiana, G; Costa, G; Costa, M J; Costa Batalha Pedro, R; Costanzo, D; Côté, D; Cottin, G; Cowan, G; Cox, B E; Cranmer, K; Cree, G; Crépé-Renaudin, S; Crescioli, F; Crispin Ortuzar, M; Cristinziani, M; Crosetti, G; Cuciuc, C-M; Cuenca Almenar, C; Cuhadar Donszelmann, T; Cummings, J; Curatolo, M; Cuthbert, C; Czirr, H; Czodrowski, P; Czyczula, Z; D'Auria, S; D'Onofrio, M; D'Orazio, A; Da Cunha Sargedas De Sousa, M J; Da Via, C; Dabrowski, W; Dafinca, A; Dai, T; Dallaire, F; Dallapiccola, C; Dam, M; Daniells, A C; Dano Hoffmann, M; Dao, V; Darbo, G; Darlea, G L; Darmora, S; Dassoulas, J A; Davey, W; David, C; Davidek, T; Davies, E; Davies, M; Davignon, O; Davison, A R; Davygora, Y; Dawe, E; Dawson, I; Daya-Ishmukhametova, R K; De, K; de Asmundis, R; De Castro, S; De Cecco, S; de Graat, J; De Groot, N; de Jong, P; De La Taille, C; De la Torre, H; De Lorenzi, F; De Nooij, L; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; De Vivie De Regie, J B; De Zorzi, G; Dearnaley, W J; Debbe, R; Debenedetti, C; Dechenaux, B; Dedovich, D V; Degenhardt, J; Deigaard, I; Del Peso, J; Del Prete, T; Delemontex, T; Deliot, F; Deliyergiyev, M; Dell'acqua, A; Dell'asta, L; Della Pietra, M; Della Volpe, D; Delmastro, M; Delsart, P A; Deluca, C; Demers, S; Demichev, M; Demilly, A; Demirkoz, B; Denisov, S P; Derendarz, D; Derkaoui, J E; Derue, F; Dervan, P; Desch, K; Deviveiros, P O; Dewhurst, A; Dhaliwal, S; Di Ciaccio, A; Di Ciaccio, L; Di Donato, C; Di Girolamo, A; Di Girolamo, B; Di Mattia, A; Di Micco, B; Di Nardo, R; Di Simone, A; Di Sipio, R; Di Valentino, D; Diaz, M A; Diehl, E B; Dietrich, J; Dietzsch, T A; Diglio, S; Dimitrievska, A; Dindar Yagci, K; Dingfelder, J; Dionisi, C; Dita, P; Dita, S; Dittus, F; Djama, F; Djobava, T; do Vale, M A B; Do Valle Wemans, A; Doan, T K O; Dobos, D; Dobson, E; Doglioni, C; Doherty, T; Dohmae, T; Dolejsi, J; Dolezal, Z; Dolgoshein, B A; Donadelli, M; Donati, S; Dondero, P; Donini, J; Dopke, J; Doria, A; Dos Anjos, A; Dotti, A; Dova, M T; Doyle, A T; Dris, M; Dubbert, J; Dube, S; Dubreuil, E; Duchovni, E; Duckeck, G; Ducu, O A; Duda, D; Dudarev, A; Dudziak, F; Duflot, L; Duguid, L; Dührssen, M; Dunford, M; Duran Yildiz, H; Düren, M; Dwuznik, M; Ebke, J; Edson, W; Edwards, C A; Edwards, N C; Ehrenfeld, W; Eifert, T; Eigen, G; Einsweiler, K; Ekelof, T; El Kacimi, M; Ellert, M; Elles, S; Ellinghaus, F; Ellis, K; Ellis, N; Elmsheuser, J; Elsing, M; Emeliyanov, D; Enari, Y; Endner, O C; Endo, M; Engelmann, R; Erdmann, J; Ereditato, A; Eriksson, D; Ernis, G; Ernst, J; Ernst, M; Ernwein, J; Errede, D; Errede, S; Ertel, E; Escalier, M; Esch, H; Escobar, C; Espinal Curull, X; Esposito, B; Etienne, F; Etienvre, A I; Etzion, E; Evangelakou, D; Evans, H; Fabbri, L; Facini, G; Fakhrutdinov, R M; Falciano, S; Fang, Y; Fanti, M; Farbin, A; Farilla, A; Farooque, T; Farrell, S; Farrington, S M; Farthouat, P; Fassi, F; Fassnacht, P; Fassouliotis, D; Fatholahzadeh, B; Favareto, A; Fayard, L; Federic, P; Fedin, O L; Fedorko, W; Fehling-Kaschek, M; Feigl, S; Feligioni, L; Feng, C; Feng, E J; Feng, H; Fenyuk, A B; Fernandez Perez, S; Fernando, W; Ferrag, S; Ferrando, J; Ferrara, V; Ferrari, A; Ferrari, P; Ferrari, R; Ferreira de Lima, D E; Ferrer, A; Ferrere, D; Ferretti, C; Ferretto Parodi, A; Fiascaris, M; Fiedler, F; Filipčič, A; Filipuzzi, M; Filthaut, F; Fincke-Keeler, M; Finelli, K D; Fiolhais, M C N; Fiorini, L; Firan, A; Fischer, J; Fisher, M J; Fitzgerald, E A; Flechl, M; Fleck, I; Fleischmann, P; Fleischmann, S; Fletcher, G T; Fletcher, G; Flick, T; Floderus, A; Flores Castillo, L R; Florez Bustos, A C; Flowerdew, M J; Formica, A; Forti, A; Fortin, D; Fournier, D; Fox, H; Francavilla, P; Franchini, M; Franchino, S; Francis, D; Franklin, M; Franz, S; Fraternali, M; Fratina, S; French, S T; Friedrich, C; Friedrich, F; Froidevaux, D; Frost, J A; Fukunaga, C; Fullana Torregrosa, E; Fulsom, B G; Fuster, J; Gabaldon, C; Gabizon, O; Gabrielli, A; Gabrielli, A; Gadatsch, S; Gadfort, T; Gadomski, S; Gagliardi, G; Gagnon, P; Galea, C; Galhardo, B; Gallas, E J; Gallo, V; Gallop, B J; Gallus, P; Galster, G; Gan, K K; Gandrajula, R P; Gao, J; Gao, Y S; Garay Walls, F M; Garberson, F; García, C; García Navarro, J E; Garcia-Sciveres, M; Gardner, R W; Garelli, N; Garonne, V; Gatti, C; Gaudio, G; Gaur, B; Gauthier, L; Gauzzi, P; Gavrilenko, I L; Gay, C; Gaycken, G; Gazis, E N; Ge, P; Gecse, Z; Gee, C N P; Geerts, D A A; Geich-Gimbel, Ch; Gellerstedt, K; Gemme, C; Gemmell, A; Genest, M H; Gentile, S; George, M; George, S; Gerbaudo, D; Gershon, A; Ghazlane, H; Ghodbane, N; Giacobbe, B; Giagu, S; Giangiobbe, V; Giannetti, P; Gianotti, F; Gibbard, B; Gibson, S M; Gilchriese, M; Gillam, T P S; Gillberg, D; Gillman, A R; Gingrich, D M; Giokaris, N; Giordani, M P; Giordano, R; Giorgi, F M; Giovannini, P; Giraud, P F; Giugni, D; Giuliani, C; Giunta, M; Gjelsten, B K; Gkialas, I; Gladilin, L K; Glasman, C; Glatzer, J; Glazov, A; Glonti, G L; Goblirsch-Kolb, M; Goddard, J R; Godfrey, J; Godlewski, J; Goeringer, C; Goldfarb, S; Golling, T; Golubkov, D; Gomes, A; Gomez Fajardo, L S; Gonçalo, R; Goncalves Pinto Firmino Da Costa, J; Gonella, L; González de la Hoz, S; Gonzalez Parra, G; Gonzalez Silva, M L; Gonzalez-Sevilla, S; Goossens, L; Gorbounov, P A; Gordon, H A; Gorelov, I; Gorfine, G; Gorini, B; Gorini, E; Gorišek, A; Gornicki, E; Goshaw, A T; Gössling, C; Gostkin, M I; Gouighri, M; Goujdami, D; Goulette, M P; Goussiou, A G; Goy, C; Gozpinar, S; Grabas, H M X; Graber, L; Grabowska-Bold, I; Grafström, P; Grahn, K-J; Gramling, J; Gramstad, E; Grancagnolo, F; Grancagnolo, S; Grassi, V; Gratchev, V; Gray, H M; Gray, J A; Graziani, E; Grebenyuk, O G; Greenwood, Z D; Gregersen, K; Gregor, I M; Grenier, P; Griffiths, J; Grigalashvili, N; Grillo, A A; Grimm, K; Grinstein, S; Gris, Ph; Grishkevich, Y V; Grivaz, J-F; Grohs, J P; Grohsjean, A; Gross, E; Grosse-Knetter, J; Grossi, G C; Groth-Jensen, J; Grout, Z J; Grybel, K; Guan, L; Guescini, F; Guest, D; Gueta, O; Guicheney, C; Guido, E; Guillemin, T; Guindon, S; Gul, U; Gumpert, C; Gunther, J; Guo, J; Gupta, S; Gutierrez, P; Gutierrez Ortiz, N G; Gutschow, C; Guttman, N; Guyot, C; Gwenlan, C; Gwilliam, C B; Haas, A; Haber, C; Hadavand, H K; Haefner, P; Hageboeck, S; Hajduk, Z; Hakobyan, H; Haleem, M; Hall, D; Halladjian, G; Hamacher, K; Hamal, P; Hamano, K; Hamer, M; Hamilton, A; Hamilton, S; Han, L; Hanagaki, K; Hanawa, K; Hance, M; Hanke, P; Hansen, J R; Hansen, J B; Hansen, J D; Hansen, P H; Hansson, P; Hara, K; Hard, A S; Harenberg, T; Harkusha, S; Harper, D; Harrington, R D; Harris, O M; Harrison, P F; Hartjes, F; Harvey, A; Hasegawa, S; Hasegawa, Y; Hassani, S; Haug, S; Hauschild, M; Hauser, R; Havranek, M; Hawkes, C M; Hawkings, R J; Hawkins, A D; Hayashi, T; Hayden, D; Hays, C P; Hayward, H S; Haywood, S J; Head, S J; Heck, T; Hedberg, V; Heelan, L; Heim, S; Heim, T; Heinemann, B; Heinrich, L; Heisterkamp, S; Hejbal, J; Helary, L; Heller, C; Heller, M; Hellman, S; Hellmich, D; Helsens, C; Henderson, J; Henderson, R C W; Hengler, C; Henrichs, A; Henriques Correia, A M; Henrot-Versille, S; Hensel, C; Herbert, G H; Hernández Jiménez, Y; Herrberg-Schubert, R; Herten, G; Hertenberger, R; Hervas, L; Hesketh, G G; Hessey, N P; Hickling, R; Higón-Rodriguez, E; Hill, J C; Hiller, K H; Hillert, S; Hillier, S J; Hinchliffe, I; Hines, E; Hirose, M; Hirschbuehl, D; Hobbs, J; Hod, N; Hodgkinson, M C; Hodgson, P; Hoecker, A; Hoeferkamp, M R; Hoffman, J; Hoffmann, D; Hofmann, J I; Hohlfeld, M; Holmes, T R; Hong, T M; Hooft van Huysduynen, L; Hostachy, J-Y; Hou, S; Hoummada, A; Howard, J; Howarth, J; Hrabovsky, M; Hristova, I; Hrivnac, J; Hryn'ova, T; Hsu, P J; Hsu, S-C; Hu, D; Hu, X; Huang, Y; Hubacek, Z; Hubaut, F; Huegging, F; Huettmann, A; Huffman, T B; Hughes, E W; Hughes, G; Huhtinen, M; Hülsing, T A; Hurwitz, M; Huseynov, N; Huston, J; Huth, J; Iacobucci, G; Iakovidis, G; Ibragimov, I; Iconomidou-Fayard, L; Idarraga, J; Ideal, E; Iengo, P; Igonkina, O; Iizawa, T; Ikegami, Y; Ikematsu, K; Ikeno, M; Iliadis, D; Ilic, N; Inamaru, Y; Ince, T; Ioannou, P; Iodice, M; Iordanidou, K; Ippolito, V; Irles Quiles, A; Isaksson, C; Ishino, M; Ishitsuka, M; Ishmukhametov, R; Issever, C; Istin, S; Iturbe Ponce, J M; Ivashin, A V; Iwanski, W; Iwasaki, H; Izen, J M; Izzo, V; Jackson, B; Jackson, J N; Jackson, M; Jackson, P; Jaekel, M R; Jain, V; Jakobs, K; Jakobsen, S; Jakoubek, T; Jakubek, J; Jamin, D O; Jana, D K; Jansen, E; Jansen, H; Janssen, J; Janus, M; Jarlskog, G; Jeanty, L; Jeng, G-Y; Jen-La Plante, I; Jennens, D; Jenni, P; Jentzsch, J; Jeske, C; Jézéquel, S; Jha, M K; Ji, H; Ji, W; Jia, J; Jiang, Y; Jimenez Belenguer, M; Jin, S; Jinaru, A; Jinnouchi, O; Joergensen, M D; Joffe, D; Johansson, K E; Johansson, P; Johns, K A; Jon-And, K; Jones, G; Jones, R W L; Jones, T J; Jorge, P M; Joshi, K D; Jovicevic, J; Ju, X; Jung, C A; Jungst, R M; Jussel, P; Juste Rozas, A; Kaci, M; Kaczmarska, A; Kado, M; Kagan, H; Kagan, M; Kajomovitz, E; Kama, S; Kanaya, N; Kaneda, M; Kaneti, S; Kanno, T; Kantserov, V A; Kanzaki, J; Kaplan, B; Kapliy, A; Kar, D; Karakostas, K; Karastathis, N; Karnevskiy, M; Karpov, S N; Karthik, K; Kartvelishvili, V; Karyukhin, A N; Kashif, L; Kasieczka, G; Kass, R D; Kastanas, A; Kataoka, Y; Katre, A; Katzy, J; Kaushik, V; Kawagoe, K; Kawamoto, T; Kawamura, G; Kazama, S; Kazanin, V F; Kazarinov, M Y; Keeler, R; Keener, P T; Kehoe, R; Keil, M; Keller, J S; Keoshkerian, H; Kepka, O; Kerševan, B P; Kersten, S; Kessoku, K; Keung, J; Khalil-Zada, F; Khandanyan, H; Khanov, A; Kharchenko, D; Khodinov, A; Khomich, A; Khoo, T J; Khoriauli, G; Khoroshilov, A; Khovanskiy, V; Khramov, E; Khubua, J; Kim, H; Kim, S H; Kimura, N; Kind, O; King, B T; King, M; King, R S B; King, S B; Kirk, J; Kiryunin, A E; Kishimoto, T; Kisielewska, D; Kitamura, T; Kittelmann, T; Kiuchi, K; Kladiva, E; Klein, M; Klein, U; Kleinknecht, K; Klimek, P; Klimentov, A; Klingenberg, R; Klinger, J A; Klinkby, E B; Klioutchnikova, T; Klok, P F; Kluge, E-E; Kluit, P; Kluth, S; Kneringer, E; Knoops, E B F G; Knue, A; Kobayashi, T; Kobel, M; Kocian, M; Kodys, P; Koenig, S; Koevesarki, P; Koffas, T; Koffeman, E; Kogan, L A; Kohlmann, S; Kohout, Z; Kohriki, T; Koi, T; Kolanoski, H; Koletsou, I; Koll, J; Komar, A A; Komori, Y; Kondo, T; Köneke, K; König, A C; Kono, T; Konoplich, R; Konstantinidis, N; Kopeliansky, R; Koperny, S; Köpke, L; Kopp, A K; Korcyl, K; Kordas, K; Korn, A; Korol, A A; Korolkov, I; Korolkova, E V; Korotkov, V A; Kortner, O; Kortner, S; Kostyukhin, V V; Kotov, S; Kotov, V M; Kotwal, A; Kourkoumelis, C; Kouskoura, V; Koutsman, A; Kowalewski, R; Kowalski, T Z; Kozanecki, W; Kozhin, A S; Kral, V; Kramarenko, V A; Kramberger, G; Krasnopevtsev, D; Krasny, M W; Krasznahorkay, A; Kraus, J K; Kravchenko, A; Kreiss, S; Kretzschmar, J; Kreutzfeldt, K; Krieger, N; Krieger, P; Kroeninger, K; Kroha, H; Kroll, J; Kroseberg, J; Krstic, J; Kruchonak, U; Krüger, H; Kruker, T; Krumnack, N; Krumshteyn, Z V; Kruse, A; Kruse, M C; Kruskal, M; Kubota, T; Kuday, S; Kuehn, S; Kugel, A; Kuhl, T; Kukhtin, V; Kulchitsky, Y; Kuleshov, S; Kuna, M; Kunkle, J; Kupco, A; Kurashige, H; Kurochkin, Y A; Kurumida, R; Kus, V; Kuwertz, E S; Kuze, M; Kvita, J; La Rosa, A; La Rotonda, L; Labarga, L; Lablak, S; Lacasta, C; Lacava, F; Lacey, J; Lacker, H; Lacour, D; Lacuesta, V R; Ladygin, E; Lafaye, R; Laforge, B; Lagouri, T; Lai, S; Laier, H; Laisne, E; Lambourne, L; Lampen, C L; Lampl, W; Lançon, E; Landgraf, U; Landon, M P J; Lang, V S; Lange, C; Lankford, A J; Lanni, F; Lantzsch, K; Lanza, A; Laplace, S; Lapoire, C; Laporte, J F; Lari, T; Larner, A; Lassnig, M; Laurelli, P; Lavorini, V; Lavrijsen, W; Laycock, P; Le, B T; Le Dortz, O; Le Guirriec, E; Le Menedeu, E; Lecompte, T; Ledroit-Guillon, F; Lee, C A; Lee, H; Lee, J S H; Lee, S C; Lee, L; Lefebvre, G; Lefebvre, M; Legger, F; Leggett, C; Lehan, A; Lehmacher, M; Lehmann Miotto, G; Lei, X; Leister, A G; Leite, M A L; Leitner, R; Lellouch, D; Lemmer, B; Leney, K J C; Lenz, T; Lenzen, G; Lenzi, B; Leone, R; Leonhardt, K; Leontsinis, S; Leroy, C; Lester, C G; Lester, C M; Levêque, J; Levin, D; Levinson, L J; Lewis, A; Lewis, G H; Leyko, A M; Leyton, M; Li, B; Li, B; Li, H; Li, H L; Li, S; Li, X; Liang, Z; Liao, H; Liberti, B; Lichard, P; Lie, K; Liebal, J; Liebig, W; Limbach, C; Limosani, A; Limper, M; Lin, S C; Linde, F; Lindquist, B E; Linnemann, J T; Lipeles, E; Lipniacka, A; Lisovyi, M; Liss, T M; Lissauer, D; Lister, A; Litke, A M; Liu, B; Liu, D; Liu, J B; Liu, K; Liu, L; Liu, M; Liu, M; Liu, Y; Livan, M; Livermore, S S A; Lleres, A; Llorente Merino, J; Lloyd, S L; Lo Sterzo, F; Lobodzinska, E; Loch, P; Lockman, W S; Loddenkoetter, T; Loebinger, F K; Loevschall-Jensen, A E; Loginov, A; Loh, C W; Lohse, T; Lohwasser, K; Lokajicek, M; Lombardo, V P; Long, J D; Long, R E; Lopes, L; Lopez Mateos, D; Lopez Paredes, B; Lorenz, J; Lorenzo Martinez, N; Losada, M; Loscutoff, P; Losty, M J; Lou, X; Lounis, A; Love, J; Love, P A; Lowe, A J; Lu, F; Lubatti, H J; Luci, C; Lucotte, A; Ludwig, D; Ludwig, I; Luehring, F; Lukas, W; Luminari, L; Lundberg, J; Lundberg, O; Lund-Jensen, B; Lungwitz, M; Lynn, D; Lysak, R; Lytken, E; Ma, H; Ma, L L; Maccarrone, G; Macchiolo, A; Maček, B; Machado Miguens, J; Macina, D; Mackeprang, R; Madar, R; Maddocks, H J; Mader, W F; Madsen, A; Maeno, M; Maeno, T; Magnoni, L; Magradze, E; Mahboubi, K; Mahlstedt, J; Mahmoud, S; Mahout, G; Maiani, C; Maidantchik, C; Maio, A; Majewski, S; Makida, Y; Makovec, N; Mal, P; Malaescu, B; Malecki, Pa; Maleev, V P; Malek, F; Mallik, U; Malon, D; Malone, C; Maltezos, S; Malyshev, V M; Malyukov, S; Mamuzic, J; Mandelli, B; Mandelli, L; Mandić, I; Mandrysch, R; Maneira, J; Manfredini, A; Manhaes de Andrade Filho, L; Manjarres Ramos, J A; Mann, A; Manning, P M; Manousakis-Katsikakis, A; Mansoulie, B; Mantifel, R; Mapelli, L; March, L; Marchand, J F; Marchese, F; Marchiori, G; Marcisovsky, M; Marino, C P; Marques, C N; Marroquim, F; Marshall, Z; Marti, L F; Marti-Garcia, S; Martin, B; Martin, B; Martin, J P; Martin, T A; Martin, V J; Martin Dit Latour, B; Martinez, H; Martinez, M; Martin-Haugh, S; Martyniuk, A C; Marx, M; Marzano, F; Marzin, A; Masetti, L; Mashimo, T; Mashinistov, R; Masik, J; Maslennikov, A L; Massa, I; Massol, N; Mastrandrea, P; Mastroberardino, A; Masubuchi, T; Matsunaga, H; Matsushita, T; Mättig, P; Mättig, S; Mattmann, J; Mattravers, C; Maurer, J; Maxfield, S J; Maximov, D A; Mazini, R; Mazzaferro, L; Mc Goldrick, G; Mc Kee, S P; McCarn, A; McCarthy, R L; McCarthy, T G; McCubbin, N A; McFarlane, K W; McFayden, J A; McHedlidze, G; McLaughlan, T; McMahon, S J; McPherson, R A; Meade, A; Mechnich, J; Mechtel, M; Medinnis, M; Meehan, S; Meera-Lebbai, R; Mehlhase, S; Mehta, A; Meier, K; Meineck, C; Meirose, B; Melachrinos, C; Mellado Garcia, B R; Meloni, F; Mendoza Navas, L; Mengarelli, A; Menke, S; Meoni, E; Mercurio, K M; Mergelmeyer, S; Meric, N; Mermod, P; Merola, L; Meroni, C; Merritt, F S; Merritt, H; Messina, A; Metcalfe, J; Mete, A S; Meyer, C; Meyer, C; Meyer, J-P; Meyer, J; Meyer, J; Middleton, R P; Migas, S; Mijović, L; Mikenberg, G; Mikestikova, M; Mikuž, M; Miller, D W; Mills, C; Milov, A; Milstead, D A; Milstein, D; Minaenko, A A; Miñano Moya, M; Minashvili, I A; Mincer, A I; Mindur, B; Mineev, M; Ming, Y; Mir, L M; Mirabelli, G; Mitani, T; Mitrevski, J; Mitsou, V A; Mitsui, S; Miucci, A; Miyagawa, P S; Mjörnmark, J U; Moa, T; Moeller, V; Mohapatra, S; Mohr, W; Molander, S; Moles-Valls, R; Mönig, K; Monini, C; Monk, J; Monnier, E; Montejo Berlingen, J; Monticelli, F; Monzani, S; Moore, R W; Mora Herrera, C; Moraes, A; Morange, N; Morel, J; Moreno, D; Moreno Llácer, M; Morettini, P; Morgenstern, M; Morii, M; Moritz, S; Morley, A K; Mornacchi, G; Morris, J D; Morvaj, L; Moser, H G; Mosidze, M; Moss, J; Mount, R; Mountricha, E; Mouraviev, S V; Moyse, E J W; Muanza, S G; Mudd, R D; Mueller, F; Mueller, J; Mueller, K; Mueller, T; Mueller, T; Muenstermann, D; Munwes, Y; Murillo Quijada, J A; Murray, W J; Mussche, I; Musto, E; Myagkov, A G; Myska, M; Nackenhorst, O; Nadal, J; Nagai, K; Nagai, R; Nagai, Y; Nagano, K; Nagarkar, A; Nagasaka, Y; Nagel, M; Nairz, A M; Nakahama, Y; Nakamura, K; Nakamura, T; Nakano, I; Namasivayam, H; Nanava, G; Napier, A; Narayan, R; Nash, M; Nattermann, T; Naumann, T; Navarro, G; Nayyar, R; Neal, H A; Nechaeva, P Yu; Neep, T J; Negri, A; Negri, G; Negrini, M; Nektarijevic, S; Nelson, A; Nelson, T K; Nemecek, S; Nemethy, P; Nepomuceno, A A; Nessi, M; Neubauer, M S; Neumann, M; Neusiedl, A; Neves, R M; Nevski, P; Newcomer, F M; Newman, P R; Nguyen, D H; Nguyen Thi Hong, V; Nickerson, R B; Nicolaidou, R; Nicquevert, B; Nielsen, J; Nikiforou, N; Nikiforov, A; Nikolaenko, V; Nikolic-Audit, I; Nikolics, K; Nikolopoulos, K; Nilsson, P; Ninomiya, Y; Nisati, A; Nisius, R; Nobe, T; Nodulman, L; Nomachi, M; Nomidis, I; Norberg, S; Nordberg, M; Novakova, J; Nozaki, M; Nozka, L; Ntekas, K; Nuncio-Quiroz, A-E; Nunes Hanninger, G; Nunnemann, T; Nurse, E; Nuti, F; O'Brien, B J; O'grady, F; O'Neil, D C; O'Shea, V; Oakham, F G; Oberlack, H; Ocariz, J; Ochi, A; Ochoa, M I; Oda, S; Odaka, S; Ogren, H; Oh, A; Oh, S H; Ohm, C C; Ohshima, T; Okamura, W; Okawa, H; Okumura, Y; Okuyama, T; Olariu, A; Olchevski, A G; Olivares Pino, S A; Oliveira Damazio, D; Oliver Garcia, E; Olivito, D; Olszewski, A; Olszowska, J; Onofre, A; Onyisi, P U E; Oram, C J; Oreglia, M J; Oren, Y; Orestano, D; Orlando, N; Oropeza Barrera, C; Orr, R S; Osculati, B; Ospanov, R; Otero Y Garzon, G; Otono, H; Ouchrif, M; Ouellette, E A; Ould-Saada, F; Ouraou, A; Oussoren, K P; Ouyang, Q; Ovcharova, A; Owen, M; Owen, S; Ozcan, V E; Ozturk, N; Pachal, K; Pacheco Pages, A; Padilla Aranda, C; Pagan Griso, S; Paganis, E; Pahl, C; Paige, F; Pais, P; Pajchel, K; Palacino, G; Palestini, S; Pallin, D; Palma, A; Palmer, J D; Pan, Y B; Panagiotopoulou, E; Panduro Vazquez, J G; Pani, P; Panikashvili, N; Panitkin, S; Pantea, D; Papadopoulou, Th D; Papageorgiou, K; Paramonov, A; Paredes Hernandez, D; Parker, M A; Parodi, F; Parsons, J A; Parzefall, U; Pasqualucci, E; Passaggio, S; Passeri, A; Pastore, F; Pastore, Fr; Pásztor, G; Pataraia, S; Patel, N D; Pater, J R; Patricelli, S; Pauly, T; Pearce, J; Pedersen, M; Pedraza Lopez, S; Peleganchuk, S V; Pelikan, D; Peng, H; Penning, B; Penwell, J; Perepelitsa, D V; Perez Codina, E; Pérez García-Estañ, M T; Perez Reale, V; Perini, L; Pernegger, H; Perrino, R; Peschke, R; Peshekhonov, V D; Peters, K; Peters, R F Y; Petersen, B A; Petersen, J; Petersen, T C; Petit, E; Petridis, A; Petridou, C; Petrolo, E; Petrucci, F; Petteni, M; Pezoa, R; Phillips, P W; Piacquadio, G; Pianori, E; Picazio, A; Piccaro, E; Piccinini, M; Piec, S M; Piegaia, R; Pignotti, D T; Pilcher, J E; Pilkington, A D; Pina, J; Pinamonti, M; Pinder, A; Pinfold, J L; Pingel, A; Pinto, B; Pizio, C; Pleier, M-A; Pleskot, V; Plotnikova, E; Plucinski, P; Poddar, S; Podlyski, F; Poettgen, R; Poggioli, L; Pohl, D; Pohl, M; Polesello, G; Policicchio, A; Polifka, R; Polini, A; Pollard, C S; Polychronakos, V; Pomeroy, D; Pommès, K; Pontecorvo, L; Pope, B G; Popeneciu, G A; Popovic, D S; Poppleton, A; Portell Bueso, X; Pospelov, G E; Pospisil, S; Potamianos, K; Potrap, I N; Potter, C J; Potter, C T; Poulard, G; Poveda, J; Pozdnyakov, V; Prabhu, R; Pralavorio, P; Pranko, A; Prasad, S; Pravahan, R; Prell, S; Price, D; Price, J; Price, L E; Prieur, D; Primavera, M; Proissl, M; Prokofiev, K; Prokoshin, F; Protopapadaki, E; Protopopescu, S; Proudfoot, J; Prudent, X; Przybycien, M; Przysiezniak, H; Psoroulas, S; Ptacek, E; Pueschel, E; Puldon, D; Purohit, M; Puzo, P; Pylypchenko, Y; Qian, J; Quadt, A; Quarrie, D R; Quayle, W B; Quilty, D; Radeka, V; Radescu, V; Radhakrishnan, S K; Radloff, P; Ragusa, F; Rahal, G; Rajagopalan, S; Rammensee, M; Rammes, M; Randle-Conde, A S; Rangel-Smith, C; Rao, K; Rauscher, F; Rave, T C; Ravenscroft, T; Raymond, M; Read, A L; Rebuzzi, D M; Redelbach, A; Redlinger, G; Reece, R; Reeves, K; Rehnisch, L; Reinsch, A; Reisin, H; Relich, M; Rembser, C; Ren, Z L; Renaud, A; Rescigno, M; Resconi, S; Resende, B; Reznicek, P; Rezvani, R; Richter, R; Ridel, M; Rieck, P; Rijssenbeek, M; Rimoldi, A; Rinaldi, L; Ritsch, E; Riu, I; Rizatdinova, F; Rizvi, E; Robertson, S H; Robichaud-Veronneau, A; Robinson, D; Robinson, J E M; Robson, A; Rocha de Lima, J G; Roda, C; Roda Dos Santos, D; Rodrigues, L; Roe, S; Røhne, O; Rolli, S; Romaniouk, A; Romano, M; Romeo, G; Romero Adam, E; Rompotis, N; Roos, L; Ros, E; Rosati, S; Rosbach, K; Rose, A; Rose, M; Rosendahl, P L; Rosenthal, O; Rossetti, V; Rossi, E; Rossi, L P; Rosten, R; Rotaru, M; Roth, I; Rothberg, J; Rousseau, D; Royon, C R; Rozanov, A; Rozen, Y; Ruan, X; Rubbo, F; Rubinskiy, I; Rud, V I; Rudolph, C; Rudolph, M S; Rühr, F; Ruiz-Martinez, A; Rurikova, Z; Rusakovich, N A; Ruschke, A; Rutherfoord, J P; Ruthmann, N; Ruzicka, P; Ryabov, Y F; Rybar, M; Rybkin, G; Ryder, N C; Saavedra, A F; Sacerdoti, S; Saddique, A; Sadeh, I; Sadrozinski, H F-W; Sadykov, R; Safai Tehrani, F; Sakamoto, H; Sakurai, Y; Salamanna, G; Salamon, A; Saleem, M; Salek, D; Sales De Bruin, P H; Salihagic, D; Salnikov, A; Salt, J; Salvachua Ferrando, B M; Salvatore, D; Salvatore, F; Salvucci, A; Salzburger, A; Sampsonidis, D; Sanchez, A; Sánchez, J; Sanchez Martinez, V; Sandaker, H; Sander, H G; Sanders, M P; Sandhoff, M; Sandoval, T; Sandoval, C; Sandstroem, R; Sankey, D P C; Sansoni, A; Santoni, C; Santonico, R; Santos, H; Santoyo Castillo, I; Sapp, K; Sapronov, A; Saraiva, J G; Sarkisyan-Grinbaum, E; Sarrazin, B; Sartisohn, G; Sasaki, O; Sasaki, Y; Satsounkevitch, I; Sauvage, G; Sauvan, E; Sauvan, J B; Savard, P; Savu, D O; Sawyer, C; Sawyer, L; Saxon, D H; Saxon, J; Sbarra, C; Sbrizzi, A; Scanlon, T; Scannicchio, D A; Scarcella, M; Schaarschmidt, J; Schacht, P; Schaefer, D; Schaelicke, A; Schaepe, S; Schaetzel, S; Schäfer, U; Schaffer, A C; Schaile, D; Schamberger, R D; Scharf, V; Schegelsky, V A; Scheirich, D; Schernau, M; Scherzer, M I; Schiavi, C; Schieck, J; Schillo, C; Schioppa, M; Schlenker, S; Schmidt, E; Schmieden, K; Schmitt, C; Schmitt, C; Schmitt, S; Schneider, B; Schnellbach, Y J; Schnoor, U; Schoeffel, L; Schoening, A; Schoenrock, B D; Schorlemmer, A L S; Schott, M; Schouten, D; Schovancova, J; Schram, M; Schramm, S; Schreyer, M; Schroeder, C; Schroer, N; Schuh, N; Schultens, M J; Schultz-Coulon, H-C; Schulz, H; Schumacher, M; Schumm, B A; Schune, Ph; Schwartzman, A; Schwegler, Ph; Schwemling, Ph; Schwienhorst, R; Schwindling, J; Schwindt, T; Schwoerer, M; Sciacca, F G; Scifo, E; Sciolla, G; Scott, W G; Scuri, F; Scutti, F; Searcy, J; Sedov, G; Sedykh, E; Seidel, S C; Seiden, A; Seifert, F; Seixas, J M; Sekhniaidze, G; Sekula, S J; Selbach, K E; Seliverstov, D M; Sellers, G; Seman, M; Semprini-Cesari, N; Serfon, C; Serin, L; Serkin, L; Serre, T; Seuster, R; Severini, H; Sforza, F; Sfyrla, A; Shabalina, E; Shamim, M; Shan, L Y; Shank, J T; Shao, Q T; Shapiro, M; Shatalov, P B; Shaw, K; Sherwood, P; Shimizu, S; Shimmin, C O; Shimojima, M; Shin, T; Shiyakova, M; Shmeleva, A; Shochet, M J; Short, D; Shrestha, S; Shulga, E; Shupe, M A; Shushkevich, S; Sicho, P; Sidorov, D; Sidoti, A; Siegert, F; Sijacki, Dj; Silbert, O; Silva, J; Silver, Y; Silverstein, D; Silverstein, S B; Simak, V; Simard, O; Simic, Lj; Simion, S; Simioni, E; Simmons, B; Simoniello, R; Simonyan, M; Sinervo, P; Sinev, N B; Sipica, V; Siragusa, G; Sircar, A; Sisakyan, A N; Sivoklokov, S Yu; Sjölin, J; Sjursen, T B; Skinnari, L A; Skottowe, H P; Skovpen, K Yu; Skubic, P; Slater, M; Slavicek, T; Sliwa, K; Smakhtin, V; Smart, B H; Smestad, L; Smirnov, S Yu; Smirnov, Y; Smirnova, L N; Smirnova, O; Smith, K M; Smizanska, M; Smolek, K; Snesarev, A A; Snidero, G; Snow, J; Snyder, S; Sobie, R; Socher, F; Sodomka, J; Soffer, A; Soh, D A; Solans, C A; Solar, M; Solc, J; Soldatov, E Yu; Soldevila, U; Solfaroli Camillocci, E; Solodkov, A A; Solovyanov, O V; Solovyev, V; Soni, N; Sood, A; Sopko, V; Sopko, B; Sosebee, M; Soualah, R; Soueid, P; Soukharev, A M; South, D; Spagnolo, S; Spanò, F; Spearman, W R; Spighi, R; Spigo, G; Spousta, M; Spreitzer, T; Spurlock, B; St Denis, R D; Stahlman, J; Stamen, R; Stanecka, E; Stanek, R W; Stanescu, C; Stanescu-Bellu, M; Stanitzki, M M; Stapnes, S; Starchenko, E A; Stark, J; Staroba, P; Starovoitov, P; Staszewski, R; Stavina, P; Steele, G; Steinbach, P; Steinberg, P; Stekl, I; Stelzer, B; Stelzer, H J; Stelzer-Chilton, O; Stenzel, H; Stern, S; Stewart, G A; Stillings, J A; Stockton, M C; Stoebe, M; Stoerig, K; Stoicea, G; Stonjek, S; Stradling, A R; Straessner, A; Strandberg, J; Strandberg, S; Strandlie, A; Strauss, E; Strauss, M; Strizenec, P; Ströhmer, R; Strom, D M; Stroynowski, R; Stucci, S A; Stugu, B; Stumer, I; Stupak, J; Styles, N A; Su, D; Su, J; Subramania, Hs; Subramaniam, R; Succurro, A; Sugaya, Y; Suhr, C; Suk, M; Sulin, V V; Sultansoy, S; Sumida, T; Sun, X; Sundermann, J E; Suruliz, K; Susinno, G; Sutton, M R; Suzuki, Y; Svatos, M; Swedish, S; Swiatlowski, M; Sykora, I; Sykora, T; Ta, D; Tackmann, K; Taenzer, J; Taffard, A; Tafirout, R; Taiblum, N; Takahashi, Y; Takai, H; Takashima, R; Takeda, H; Takeshita, T; Takubo, Y; Talby, M; Talyshev, A A; Tam, J Y C; Tamsett, M C; Tan, K G; Tanaka, J; Tanaka, R; Tanaka, S; Tanaka, S; Tanasijczuk, A J; Tani, K; Tannoury, N; Tapprogge, S; Tarem, S; Tarrade, F; Tartarelli, G F; Tas, P; Tasevsky, M; Tashiro, T; Tassi, E; Tavares Delgado, A; Tayalati, Y; Taylor, C; Taylor, F E; Taylor, G N; Taylor, W; Teischinger, F A; Teixeira Dias Castanheira, M; Teixeira-Dias, P; Temming, K K; Ten Kate, H; Teng, P K; Terada, S; Terashi, K; Terron, J; Terzo, S; Testa, M; Teuscher, R J; Therhaag, J; Theveneaux-Pelzer, T; Thoma, S; Thomas, J P; Thomas-Wilsker, J; Thompson, E N; Thompson, P D; Thompson, P D; Thompson, A S; Thomsen, L A; Thomson, E; Thomson, M; Thong, W M; Thun, R P; Tian, F; Tibbetts, M J; Tic, T; Tikhomirov, V O; Tikhonov, Yu A; Timoshenko, S; Tiouchichine, E; Tipton, P; Tisserant, S; Todorov, T; Todorova-Nova, S; Toggerson, B; Tojo, J; Tokár, S; Tokushuku, K; Tollefson, K; Tomlinson, L; Tomoto, M; Tompkins, L; Toms, K; Topilin, N D; Torrence, E; Torres, H; Torró Pastor, E; Toth, J; Touchard, F; Tovey, D R; Tran, H L; Trefzger, T; Tremblet, L; Tricoli, A; Trigger, I M; Trincaz-Duvoid, S; Tripiana, M F; Triplett, N; Trischuk, W; Trocmé, B; Troncon, C; Trottier-McDonald, M; Trovatelli, M; True, P; Trzebinski, M; Trzupek, A; Tsarouchas, C; Tseng, J C-L; Tsiareshka, P V; Tsionou, D; Tsipolitis, G; Tsirintanis, N; Tsiskaridze, S; Tsiskaridze, V; Tskhadadze, E G; Tsukerman, I I; Tsulaia, V; Tsung, J-W; Tsuno, S; Tsybychev, D; Tua, A; Tudorache, A; Tudorache, V; Tuna, A N; Tupputi, S A; Turchikhin, S; Turecek, D; Turk Cakir, I; Turra, R; Tuts, P M; Tykhonov, A; Tylmad, M; Tyndel, M; Uchida, K; Ueda, I; Ueno, R; Ughetto, M; Ugland, M; Uhlenbrock, M; Ukegawa, F; Unal, G; Undrus, A; Unel, G; Ungaro, F C; Unno, Y; Urbaniec, D; Urquijo, P; Usai, G; Usanova, A; Vacavant, L; Vacek, V; Vachon, B; Valencic, N; Valentinetti, S; Valero, A; Valery, L; Valkar, S; Valladolid Gallego, E; Vallecorsa, S; Valls Ferrer, J A; Van Berg, R; Van Der Deijl, P C; van der Geer, R; van der Graaf, H; Van Der Leeuw, R; van der Ster, D; van Eldik, N; van Gemmeren, P; Van Nieuwkoop, J; van Vulpen, I; van Woerden, M C; Vanadia, M; Vandelli, W; Vaniachine, A; Vankov, P; Vannucci, F; Vardanyan, G; Vari, R; Varnes, E W; Varol, T; Varouchas, D; Vartapetian, A; Varvell, K E; Vassilakopoulos, V I; Vazeille, F; Vazquez Schroeder, T; Veatch, J; Veloso, F; Veneziano, S; Ventura, A; Ventura, D; Venturi, M; Venturi, N; Venturini, A; Vercesi, V; Verducci, M; Verkerke, W; Vermeulen, J C; Vest, A; Vetterli, M C; Viazlo, O; Vichou, I; Vickey, T; Vickey Boeriu, O E; Viehhauser, G H A; Viel, S; Vigne, R; Villa, M; Villaplana Perez, M; Vilucchi, E; Vincter, M G; Vinogradov, V B; Virzi, J; Vitells, O; Vivarelli, I; Vives Vaque, F; Vlachos, S; Vladoiu, D; Vlasak, M; Vogel, A; Vokac, P; Volpi, G; Volpi, M; von der Schmitt, H; von Radziewski, H; von Toerne, E; Vorobel, V; Vos, M; Voss, R; Vossebeld, J H; Vranjes, N; Vranjes Milosavljevic, M; Vrba, V; Vreeswijk, M; Vu Anh, T; Vuillermet, R; Vukotic, I; Vykydal, Z; Wagner, W; Wagner, P; Wahrmund, S; Wakabayashi, J; Walder, J; Walker, R; Walkowiak, W; Wall, R; Waller, P; Walsh, B; Wang, C; Wang, C; Wang, H; Wang, H; Wang, J; Wang, J; Wang, K; Wang, R; Wang, S M; Wang, T; Wang, X; Warburton, A; Ward, C P; Wardrope, D R; Warsinsky, M; Washbrook, A; Wasicki, C; Watanabe, I; Watkins, P M; Watson, A T; Watson, I J; Watson, M F; Watts, G; Watts, S; Waugh, A T; Waugh, B M; Webb, S; Weber, M S; Weber, S W; Webster, J S; Weidberg, A R; Weigell, P; Weingarten, J; Weiser, C; Weits, H; Wells, P S; Wenaus, T; Wendland, D; Weng, Z; Wengler, T; Wenig, S; Wermes, N; Werner, M; Werner, P; Wessels, M; Wetter, J; Whalen, K; White, A; White, M J; White, R; White, S; Whiteson, D; Whittington, D; Wicke, D; Wickens, F J; Wiedenmann, W; Wielers, M; Wienemann, P; Wiglesworth, C; Wiik-Fuchs, L A M; Wijeratne, P A; Wildauer, A; Wildt, M A; Wilkens, H G; Will, J Z; Williams, H H; Williams, S; Willocq, S; Wilson, J A; Wilson, A; Wingerter-Seez, I; Winkelmann, S; Winklmeier, F; Wittgen, M; Wittig, T; Wittkowski, J; Wollstadt, S J; Wolter, M W; Wolters, H; Wosiek, B K; Wotschack, J; Woudstra, M J; Wozniak, K W; Wraight, K; Wright, M; Wu, S L; Wu, X; Wu, Y; Wulf, E; Wyatt, T R; Wynne, B M; Xella, S; Xiao, M; Xu, D; Xu, L; Yabsley, B; Yacoob, S; Yamada, M; Yamaguchi, H; Yamaguchi, Y; Yamamoto, A; Yamamoto, K; Yamamoto, S; Yamamura, T; Yamanaka, T; Yamauchi, K; Yamazaki, Y; Yan, Z; Yang, H; Yang, H; Yang, U K; Yang, Y; Yanush, S; Yao, L; Yasu, Y; Yatsenko, E; Yau Wong, K H; Ye, J; Ye, S; Yen, A L; Yildirim, E; Yilmaz, M; Yoosoofmiya, R; Yorita, K; Yoshida, R; Yoshihara, K; Young, C; Young, C J S; Youssef, S; Yu, D R; Yu, J; Yu, J M; Yu, J; Yuan, L; Yurkewicz, A; Zabinski, B; Zaidan, R; Zaitsev, A M; Zaman, A; Zambito, S; Zanello, L; Zanzi, D; Zaytsev, A; Zeitnitz, C; Zeman, M; Zemla, A; Zengel, K; Zenin, O; Zeniš, T; Zerwas, D; Zevi Della Porta, G; Zhang, D; Zhang, H; Zhang, J; Zhang, L; Zhang, X; Zhang, Z; Zhao, Z; Zhemchugov, A; Zhong, J; Zhou, B; Zhou, L; Zhou, N; Zhu, C G; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zibell, A; Zieminska, D; Zimin, N I; Zimmermann, C; Zimmermann, R; Zimmermann, S; Zimmermann, S; Zinonos, Z; Ziolkowski, M; Zitoun, R; Zivković, L; Zobernig, G; Zoccoli, A; Zur Nedden, M; Zurzolo, G; Zutshi, V; Zwalinski, L

    2014-03-01

    This Letter presents a search for quantum black-hole production using 20.3 fb-1 of data collected with the ATLAS detector in pp collisions at the LHC at √s = 8 TeV. The quantum black holes are assumed to decay into a final state characterized by a lepton (electron or muon) and a jet. In either channel, no event with a lepton-jet invariant mass of 3.5 TeV or more is observed, consistent with the expected background. Limits are set on the product of cross sections and branching fractions for the lepton+jet final states of quantum black holes produced in a search region for invariant masses above 1 TeV. The combined 95% confidence level upper limit on this product for quantum black holes with threshold mass above 3.5 TeV is 0.18 fb. This limit constrains the threshold quantum black-hole mass to be above 5.3 TeV in the model considered.

  8. G4-DNA Formation in the HRAS Promoter and Rational Design of Decoy Oligonucleotides for Cancer Therapy

    PubMed Central

    Membrino, Alexandro; Cogoi, Susanna; Pedersen, Erik B.; Xodo, Luigi E.

    2011-01-01

    HRAS is a proto-oncogene involved in the tumorigenesis of urinary bladder cancer. In the HRAS promoter we identified two G-rich elements, hras-1 and hras-2, that fold, respectively, into an antiparallel and a parallel quadruplex (qhras-1, qhras-2). When we introduced in sequence hras-1 or hras-2 two point mutations that block quadruplex formation, transcription increased 5-fold, but when we stabilized the G-quadruplexes by guanidinium phthalocyanines, transcription decreased to 20% of control. By ChIP we found that sequence hras-1 is bound only by MAZ, while hras-2 is bound by MAZ and Sp1: two transcription factors recognizing guanine boxes. We also discovered by EMSA that recombinant MAZ-GST binds to both HRAS quadruplexes, while Sp1-GST only binds to qhras-1. The over-expression of MAZ and Sp1 synergistically activates HRAS transcription, while silencing each gene by RNAi results in a strong down-regulation of transcription. All these data indicate that the HRAS G-quadruplexes behave as transcription repressors. Finally, we designed decoy oligonucleotides mimicking the HRAS quadruplexes, bearing (R)-1-O-[4-(1-Pyrenylethynyl) phenylmethyl] glycerol and LNA modifications to increase their stability and nuclease resistance (G4-decoys). The G4-decoys repressed HRAS transcription and caused a strong antiproliferative effect, mediated by apoptosis, in T24 bladder cancer cells where HRAS is mutated. PMID:21931711

  9. A myostatin and activin decoy receptor enhances bone formation in mice.

    PubMed

    Bialek, P; Parkington, J; Li, X; Gavin, D; Wallace, C; Zhang, J; Root, A; Yan, G; Warner, L; Seeherman, H J; Yaworsky, P J

    2014-03-01

    Myostatin is a member of the bone morphogenetic protein/transforming growth factor-β (BMP/TGFβ) super-family of secreted differentiation factors. Myostatin is a negative regulator of muscle mass as shown by increased muscle mass in myostatin deficient mice. Interestingly, these mice also exhibit increased bone mass suggesting that myostatin may also play a role in regulating bone mass. To investigate the role of myostatin in bone, young adult mice were administered with either a myostatin neutralizing antibody (Mstn-mAb), a soluble myostatin decoy receptor (ActRIIB-Fc) or vehicle. While both myostatin inhibitors increased muscle mass, only ActRIIB-Fc increased bone mass. Bone volume fraction (BV/TV), as determined by microCT, was increased by 132% and 27% in the distal femur and lumbar vertebrae, respectively. Histological evaluation demonstrated that increased BV/TV in both locations was attributed to increased trabecular thickness, trabecular number and bone formation rate. Increased BV/TV resulted in enhanced vertebral maximum compressive force compared to untreated animals. The fact that ActRIIB-Fc, but not Mstn-mAb, increased bone volume suggested that this soluble decoy receptor may be binding a ligand other than myostatin, that plays a role in regulating bone mass. This was confirmed by the significant increase in BV/TV in myostatin deficient mice treated with ActRIIB-Fc. Of the other known ActRIIB-Fc ligands, BMP3 has been identified as a negative regulator of bone mass. However, BMP3 deficient mice treated with ActRIIB-Fc showed similar increases in BV/TV as wild type (WT) littermates treated with ActRIIB-Fc. This result suggests that BMP3 neutralization is not the mechanism responsible for increased bone mass. The results of this study demonstrate that ActRIIB-Fc increases both muscle and bone mass in mice. Therefore, a therapeutic that has this dual activity represents a potential approach for the treatment of frailty. PMID:24333131

  10. Anomalous Polarization May Improve Infrared Detectors

    NASA Technical Reports Server (NTRS)

    Yang, Chan-Lon; Pan, Dee-Son

    1990-01-01

    New configurations proposed for quantum-well devices. Simplifies alignment, increases sensitivity, and opens up more possibilities in design of quantum-well detectors of infrared radiation. In detector made according to proposed concept, light incident broadside on front surface absorbed. No special waveguide structures required.

  11. Target-Decoy Approach and False Discovery Rate: When Things May Go Wrong

    NASA Astrophysics Data System (ADS)

    Gupta, Nitin; Bandeira, Nuno; Keich, Uri; Pevzner, Pavel A.

    2011-07-01

    The target-decoy approach (TDA) has done the field of proteomics a great service by filling in the need to estimate the false discovery rates (FDR) of peptide identifications. While TDA is often viewed as a universal solution to the problem of FDR evaluation, we argue that the time has come to critically re-examine TDA and to acknowledge not only its merits but also its demerits. We demonstrate that some popular MS/MS search tools are not TDA-compliant and that it is easy to develop a non-TDA compliant tool that outperforms all TDA-compliant tools. Since the distinction between TDA-compliant and non-TDA compliant tools remains elusive, we are concerned about a possible proliferation of non-TDA-compliant tools in the future (developed with the best intentions). We are also concerned that estimation of the FDR by TDA awkwardly depends on a virtual coin toss and argue that it is important to take the coin toss factor out of our estimation of the FDR. Since computing FDR via TDA suffers from various restrictions, we argue that TDA is not needed when accurate p-values of individual Peptide-Spectrum Matches are available.

  12. Comparative evaluation of tandem MS search algorithms using a target-decoy search strategy.

    PubMed

    Balgley, Brian M; Laudeman, Tom; Yang, Li; Song, Tao; Lee, Cheng S

    2007-09-01

    Peptide identification of tandem mass spectra by a variety of available search algorithms forms the foundation for much of modern day mass spectrometry-based proteomics. Despite the critical importance of proper evaluation and interpretation of the results generated by these algorithms there is still little consistency in their application or understanding of their similarities and differences. A survey was conducted of four tandem mass spectrometry peptide identification search algorithms, including Mascot, Open Mass Spectrometry Search Algorithm, Sequest, and X! Tandem. The same input data, search parameters, and sequence library were used for the searches. Comparisons were based on commonly used scoring methodologies for each algorithm and on the results of a target-decoy approach to sequence library searching. The results indicated that there is little difference in the output of the algorithms so long as consistent scoring procedures are applied. The results showed that some commonly used scoring procedures may lead to excessive false discovery rates. Finally an alternative method for the determination of an optimal cutoff threshold is proposed.

  13. Predictive value of decoy receptor 3 in postoperative nosocomial bacterial meningitis.

    PubMed

    Liu, Yong-Juan; Shao, Li-Hua; Wang, Qian; Zhang, Jian; Ma, Rui-Ping; Liu, Hai-Hong; Dong, Xiao-Meng; Ma, Li-Xian

    2014-11-03

    Nosocomial bacterial meningitis requires timely treatment, but what is difficult is the prompt and accurate diagnosis of this disease. The aim of this study was to assess the potential role of decoy receptor 3 (DcR3) levels in the differentiation of bacterial meningitis from non-bacterial meningitis. A total of 123 patients were recruited in this study, among them 80 patients being with bacterial meningitis and 43 patients with non-bacterial meningitis. Bacterial meningitis was confirmed by bacterial culture of cerebrospinal fluid (CSF) culture and enzyme-linked immunosorbent assay (ELISA) was used to detect the level of DcR3 in CSF. CSF levels of DcR3 were statistically significant between patients with bacterial meningitis and those with non-bacterial meningitis (p<0.001). A total of 48.75% of patients with bacterial meningitis received antibiotic>24 h before CSF sampling, which was much higher than that of non-bacterial meningitis. CSF leucocyte count yielded the highest diagnostic value, with an area under the receiver operating characteristic curve (ROC) of 0.928, followed by DcR3. At a critical value of 0.201 ng/mL for DcR3, the sensitivity and specificity were 78.75% and 81.40% respectively. DcR3 in CSF may be a valuable predictor for differentiating patients with bacterial meningitis from those with non-bacterial meningitis. Further studies are needed for the validation of this study.

  14. Expression of decoy receptor 3 in kidneys is associated with allograft survival after kidney transplant rejection

    PubMed Central

    Weng, Shuo-Chun; Shu, Kuo-Hsiung; Wu, Ming-Ju; Wen, Mei-Chin; Hsieh, Shie-Liang; Chen, Nien-Jung; Tarng, Der-Cherng

    2015-01-01

    Decoy receptor 3 (DcR3) expression in kidneys has been shown to predict progression of chronic kidney disease. We prospectively investigated a cohort comprising 96 renal transplant recipients (RTRs) undergoing graft kidney biopsies. Computer-assisted quantitative immunohistochemical staining value of DcR3 in renal tubular epithelial cells (RTECs) was used to determine the predictive role of DcR3 in kidney disease progression. The primary end point was doubling of serum creatinine and/or graft failure. A multivariate Cox proportional hazards model was used to assess the risk of DcR3 expression in rejected kidney grafts toward the renal end point. In total, RTRs with kidney allograft rejection were evaluated and the median follow-up was 30.9 months. The greater expression of DcR3 immunoreactivity in RTECs was correlated with a higher rate of the histopathological concordance of acute T cell-mediated rejection. Compared with 65 non-progressors, 31 progressors had higher DcR3 expression (HDE) regardless of the traditional risk factors. Cox regression analysis showed HDE was significantly associated with the risk of renal end point with a hazard ratio of 3.19 (95% confidence interval, 1.40 to 7.27; P = 0.006) after adjusting for other variables. In repetitive biopsies, HDE in tissue showed rapid kidney disease progression due to persistent inflammation. PMID:26335204

  15. A strategy to discover decoy chemokine ligands with an anti-inflammatory activity

    PubMed Central

    Abboud, Dayana; Daubeuf, François; Do, Quoc Tuan; Utard, Valérie; Villa, Pascal; Haiech, Jacques; Bonnet, Dominique; Hibert, Marcel; Bernard, Philippe; Galzi, Jean-Luc; Frossard, Nelly

    2015-01-01

    Excessive signaling by chemokines has been associated with chronic inflammation or cancer, thus attracting substantial attention as promising therapeutic targets. Inspired by chemokine-clearing molecules shaped by pathogens to escape the immune system, we designed a generic screening assay to discover chemokine neutralizing molecules (neutraligands) and unambiguously distinguish them from molecules that block the receptor (receptor antagonists). This assay, called TRIC-r, combines time-resolved intracellular calcium recordings with pre-incubation of bioactive compounds either with the chemokine or the receptor-expressing cells. We describe here the identification of high affinity neutraligands of CCL17 and CCL22, two chemokines involved in the Th2-type of lung inflammation. The decoy molecules inhibit in vitro CCL17- or CCL22-induced intracellular calcium responses, CCR4 endocytosis and human T cell migration. In vivo, they inhibit inflammation in a murine model of asthma, in particular the recruitment of eosinophils, dendritic cells and CD4+T cells. Altogether, we developed a successful strategy to discover as new class of pharmacological tools to potently control cell chemotaxis in vitro and in vivo. PMID:26442456

  16. Crosstalk-free operation of multielement superconducting nanowire single-photon detector array integrated with single-flux-quantum circuit in a 0.1 W Gifford-McMahon cryocooler.

    PubMed

    Yamashita, Taro; Miki, Shigehito; Terai, Hirotaka; Makise, Kazumasa; Wang, Zhen

    2012-07-15

    We demonstrate the successful operation of a multielement superconducting nanowire single-photon detector (SSPD) array integrated with a single-flux-quantum (SFQ) readout circuit in a compact 0.1 W Gifford-McMahon cryocooler. A time-resolved readout technique, where output signals from each element enter the SFQ readout circuit with finite time intervals, revealed crosstalk-free operation of the four-element SSPD array connected with the SFQ readout circuit. The timing jitter and the system detection efficiency were measured to be 50 ps and 11.4%, respectively, which were comparable to the performance of practical single-pixel SSPD systems.

  17. Direct Detectors for Electron Microscopy

    NASA Astrophysics Data System (ADS)

    Clough, R. N.; Moldovan, G.; Kirkland, A. I.

    2014-06-01

    There is interest in improving the detectors used to capture images in transmission electron microscopy. Detectors with an improved modulation transfer function at high spatial frequencies allow for higher resolution in images at lower magnification, which leads to an increased effective field of view. Detectors with improved detective quantum efficiency are important for low dose applications. One way in which these performance enhancements can be achieved is through direct detection, where primary electrons are converted directly into suitable electrical signals by the detector rather than relying on an indirect electron to photon conversion before detection. In this paper we present the characterisation of detector performance for a number of different direct detection technologies, and compare these technologies to traditional indirect detectors. Overall our results show that direct detection enables a significant improvement in all aspects of detector performance.

  18. The Presence of Conspecific Decoys Enhances the Attractiveness of an NaCl Resource to the Yellow-Spined Locust, Ceracris kiangsu

    PubMed Central

    Yu, Hai-Ping; Wang, Zhi-Tian; Xiao, Kai; Shao, Lin; Li, Guo-Qing

    2011-01-01

    Adults of the yellow-spined bamboo locust, Ceracris kiangsu Tsai (Orthoptera: Oedipodidae), aggregate and gnaw at human urine-contaminated materials, a phenomenon termed puddling. Several urine-borne chemicals, including NaCl, are known to stimulate adult C. kiangsu to consume filter paper. Because in nature C. kiangsu adults may use cues to locate puddling resources, we tested the influence of conspecific decoys (dried C. kiangsu) on foraging and consumption of 3% NaCl—treated filter paper. In a two—choice test experiment in the laboratory, female adults showed no preference for filter papers (not treated with NaCL) with or without decoys. In contrast, C. kiangsu females consumed significantly more NaCl—treated filter paper on which conspecific decoys were attached than those without decoys in both the laboratory and in a bamboo forest. When the bait was changed to 3% NaCl plus the insecticide bisultap, significantly more C. kiangsu were killed in the bamboo forest when decoys were present, however the results were not significant when the experiment was done in the laboratory. Hence, moving towards conspecifics seems to facilitate NaCl resource foraging in C. kiangsu, suggesting that the presence of conspecifics promotes feeding on puddling resources. PMID:21539416

  19. Infrared detectors for space applications

    NASA Astrophysics Data System (ADS)

    Cardimona, D. A.; Huang, D. H.; Cowan, V.; Morath, C.

    2011-05-01

    Two of the main requirements for space situational awareness are to locate and identify dim and/or distant objects. At the Air Force Research Laboratory's Space Vehicles Directorate, we are investigating how nanostructured metal surfaces can produce plasmon-enhanced fields to address the first function. We are also investigating quantum interference effects in semiconductor quantum dots inside photonic crystal cavities to address the amplification of weak signals. To address the second function of identification of space objects, we are investigating a wavelength-tunable detector scheme that involves a coupled double quantum well structure with a thin middle barrier between the two wells. The photocurrent from this structure will be swept out with a lateral bias. In order to eliminate the diffraction loss of incident photons by a surface grating structure for the z-polarization required in normal quantum well infrared photodetector structures, we will grow an array of self-organized quantum dots buried in one of the quantum wells of a symmetric double quantum well structure. In this paper, we will first describe the requirements for detectors in space, then we will describe our work in the above topics, and finally we will briefly mention our forays into other areas of quantum-structured detectors for use in space.

  20. Human Milk Contains Novel Glycans That Are Potential Decoy Receptors for Neonatal Rotaviruses*

    PubMed Central

    Yu, Ying; Lasanajak, Yi; Song, Xuezheng; Hu, Liya; Ramani, Sasirekha; Mickum, Megan L.; Ashline, David J.; Prasad, B. V. Venkataram; Estes, Mary K.; Reinhold, Vernon N.; Cummings, Richard D.; Smith, David F.

    2014-01-01

    Human milk contains a rich set of soluble, reducing glycans whose functions and bioactivities are not well understood. Because human milk glycans (HMGs) have been implicated as receptors for various pathogens, we explored the functional glycome of human milk using shotgun glycomics. The free glycans from pooled milk samples of donors with mixed Lewis and Secretor phenotypes were labeled with a fluorescent tag and separated via multidimensional HPLC to generate a tagged glycan library containing 247 HMG targets that were printed to generate the HMG shotgun glycan microarray (SGM). To investigate the potential role of HMGs as decoy receptors for rotavirus (RV), a leading cause of severe gastroenteritis in children, we interrogated the HMG SGM with recombinant forms of VP8* domains of the RV outer capsid spike protein VP4 from human neonatal strains N155(G10P[11]) and RV3(G3P[6]) and a bovine strain, B223(G10P[11]). Glycans that were bound by RV attachment proteins were selected for detailed structural analyses using metadata-assisted glycan sequencing, which compiles data on each glycan based on its binding by antibodies and lectins before and after exo- and endo-glycosidase digestion of the SGM, coupled with independent MSn analyses. These complementary structural approaches resulted in the identification of 32 glycans based on RV VP8* binding, many of which are novel HMGs, whose detailed structural assignments by MSn are described in a companion report. Although sialic acid has been thought to be important as a surface receptor for RVs, our studies indicated that sialic acid is not required for binding of glycans to individual VP8* domains. Remarkably, each VP8* recognized specific glycan determinants within a unique subset of related glycan structures where specificity differences arise from subtle differences in glycan structures. PMID:25048705

  1. Detectors for Tomorrow's Instruments

    NASA Technical Reports Server (NTRS)

    Moseley, Harvey

    2009-01-01

    Cryogenically cooled superconducting detectors have become essential tools for a wide range of measurement applications, ranging from quantum limited heterodyne detection in the millimeter range to direct searches for dark matter with superconducting phonon detectors operating at 20 mK. Superconducting detectors have several fundamental and practical advantages which have resulted in their rapid adoption by experimenters. Their excellent performance arises in part from reductions in noise resulting from their low operating temperatures, but unique superconducting properties provide a wide range of mechanisms for detection. For example, the steep dependence of resistance with temperature on the superconductor/normal transition provides a sensitive thermometer for calorimetric and bolometric applications. Parametric changes in the properties of superconducting resonators provides a mechanism for high sensitivity detection of submillimeter photons. From a practical point of view, the use of superconducting detectors has grown rapidly because many of these devices couple well to SQUID amplifiers, which are easily integrated with the detectors. These SQUID-based amplifiers and multiplexers have matured with the detectors; they are convenient to use, and have excellent noise performance. The first generation of fully integrated large scale superconducting detection systems are now being deployed. I will discuss the prospects for a new generation of instruments designed to take full advantage of the revolution in detector technology.

  2. Advanced Gravitational Wave Detectors

    NASA Astrophysics Data System (ADS)

    Blair, D. G.; Howell, E. J.; Ju, L.; Zhao, C.

    2012-02-01

    Part I. An Introduction to Gravitational Wave Astronomy and Detectors: 1. Gravitational waves D. G. Blair, L. Ju, C. Zhao and E. J. Howell; 2. Sources of gravitational waves D. G. Blair and E. J. Howell; 3. Gravitational wave detectors D. G. Blair, L. Ju, C. Zhao, H. Miao, E. J. Howell, and P. Barriga; 4. Gravitational wave data analysis B. S. Sathyaprakash and B. F. Schutz; 5. Network analysis L. Wen and B. F. Schutz; Part II. Current Laser Interferometer Detectors: Three Case Studies: 6. The Laser Interferometer Gravitational-Wave Observatory P. Fritschel; 7. The VIRGO detector S. Braccini; 8. GEO 600 H. Lück and H. Grote; Part III. Technology for Advanced Gravitational Wave Detectors: 9. Lasers for high optical power interferometers B. Willke and M. Frede; 10. Thermal noise, suspensions and test masses L. Ju, G. Harry and B. Lee; 11. Vibration isolation: Part 1. Seismic isolation for advanced LIGO B. Lantz; Part 2. Passive isolation J-C. Dumas; 12. Interferometer sensing and control P. Barriga; 13. Stabilizing interferometers against high optical power effects C. Zhao, L. Ju, S. Gras and D. G. Blair; Part IV. Technology for Third Generation Gravitational Wave Detectors: 14. Cryogenic interferometers J. Degallaix; 15. Quantum theory of laser-interferometer GW detectors H. Miao and Y. Chen; 16. ET. A third generation observatory M. Punturo and H. Lück; Index.

  3. Molecular stripping, targets and decoys as modulators of oscillations in the NF-κB/IκBα/DNA genetic network

    PubMed Central

    Wang, Zhipeng; Wolynes, Peter G.

    2016-01-01

    Eukaryotic transcription factors in the NF-κB family are central components of an extensive genetic network that activates cellular responses to inflammation and to a host of other external stressors. This network consists of feedback loops that involve the inhibitor IκBα, numerous downstream functional targets, and still more numerous binding sites that do not appear to be directly functional. Under steady stimulation, the regulatory network of NF-κB becomes oscillatory, and temporal patterns of NF-κB pulses appear to govern the patterns of downstream gene expression needed for immune response. Understanding how the information from external stress passes to oscillatory signals and is then ultimately relayed to gene expression is a general issue in systems biology. Recently, in vitro kinetic experiments as well as molecular simulations suggest that active stripping of NF-κB by IκBα from its binding sites can modify the traditional systems biology view of NF-κB/IκBα gene circuits. In this work, we revise the commonly adopted minimal model of the NF-κB regulatory network to account for the presence of the large number of binding sites for NF-κB along with dissociation from these sites that may proceed either by passive unbinding or by active molecular stripping. We identify regimes where the kinetics of target and decoy unbinding and molecular stripping enter a dynamic tug of war that may either compensate each other or amplify nuclear NF-κB activity, leading to distinct oscillatory patterns. Our finding that decoys and stripping play a key role in shaping the NF-κB oscillations suggests strategies to control NF-κB responses by introducing artificial decoys therapeutically. PMID:27683001

  4. Type I interferon mimetics bypass vaccinia virus decoy receptor virulence factor for protection of mice against lethal infection.

    PubMed

    Ahmed, Chulbul M; Johnson, Howard M

    2014-08-01

    The canonical model of interferon (IFN) signaling focuses solely on the activation of STAT transcription factors which, according to the model, are initiated by the singular event of cross-linkage of the receptor extracellular domain by the IFN. The IFN has no further function beyond this. The model thus provides no approach to circumventing poxviruses decoy receptors that compete with the IFN receptors for IFNs. This simple event has allowed smallpox virus to decimate human populations throughout the ages. We have developed a noncanonical model of IFN signaling that has resulted in the development of small peptide mimetics to both types I and II IFNs. In this report, we focus on a type I IFN mimetic at positions 152 to 189, IFN-α1(152-189), which corresponds to the C terminus of human IFN-α1. This mimetic functions intracellularly and is thus not recognized by the B18R vaccinia virus decoy receptor. Mimetic synthesized with an attached palmitate (lipo-) for cell penetration protects mice from a lethal dose of vaccinia virus, while the parent IFN-α1 is ineffective. Unlike IFN-α1, the mimetic does not bind to the B18R decoy receptor. It further differs from the parent IFN in that it lacks the toxicity of weight loss and bone marrow suppression in mice while at the same time possessing a strong adjuvant effect on the immune system. The mimetic is thus an innate and adaptive immune regulator that is evidence of the dynamic nature of the noncanonical model of IFN signaling, in stark contrast to the canonical or classical model of signaling.

  5. Heralded single-photon sources for quantum-key-distribution applications

    NASA Astrophysics Data System (ADS)

    Schiavon, Matteo; Vallone, Giuseppe; Ticozzi, Francesco; Villoresi, Paolo

    2016-01-01

    Single-photon sources (SPSs) are a fundamental building block for optical implementations of quantum information protocols. Among SPSs, multiple crystal heralded single-photon sources seem to give the best compromise between high pair production rate and low multiple photon events. In this work, we study their performance in a practical quantum-key-distribution experiment, by evaluating the achievable key rates. The analysis focuses on the two different schemes, symmetric and asymmetric, proposed for the practical implementation of heralded single-photon sources, with attention on the performance of their composing elements. The analysis is based on the protocol proposed by Bennett and Brassard in 1984 and on its improvement exploiting decoy state technique. Finally, a simple way of exploiting the postselection mechanism for a passive, one decoy state scheme is evaluated.

  6. Purification of noisy quantum measurements

    SciTech Connect

    Dall'Arno, Michele; D'Ariano, Giacomo Mauro; Sacchi, Massimiliano F.

    2010-10-15

    We consider the problem of improving noisy quantum measurements by suitable preprocessing strategies making many noisy detectors equivalent to a single ideal detector. For observables pertaining to finite-dimensional systems (e.g., qubits or spins) we consider preprocessing strategies that are reminiscent of quantum error correction procedures and allow one to perfectly measure an observable on a single quantum system for increasing number of inefficient detectors. For measurements of observables with an unbounded spectrum (e.g., photon number and homodyne and heterodyne detection), the purification of noisy quantum measurements can be achieved by preamplification as suggested by Yuen [Opt. Lett. 12, 789 (1987)].

  7. Transmutation detectors

    NASA Astrophysics Data System (ADS)

    Viererbl, L.; Lahodová, Z.; Klupák, V.; Sus, F.; Kučera, J.; Kůs, P.; Marek, M.

    2011-03-01

    We have designed a new type of detectors, called transmutation detectors, which can be used primarily for neutron fluence measurement. The transmutation detector method differs from the commonly used activation detector method in evaluation of detector response after irradiation. Instead of radionuclide activity measurement using radiometric methods, the concentration of stable non-gaseous nuclides generated by transmutation in the detector is measured using analytical methods like mass spectrometry. Prospective elements and nuclear reactions for transmutation detectors are listed and initial experimental results are given. The transmutation detector method could be used primarily for long-term measurement of neutron fluence in fission nuclear reactors, but in principle it could be used for any type of radiation that can cause transmutation of nuclides in detectors. This method could also be used for measurement in accelerators or fusion reactors.

  8. Revisiting Deng et al.'s Multiparty Quantum Secret Sharing Protocol

    NASA Astrophysics Data System (ADS)

    Hwang, Tzonelih; Hwang, Cheng-Chieh; Yang, Chun-Wei; Li, Chuan-Ming

    2011-09-01

    The multiparty quantum secret sharing protocol [Deng et al. in Chin. Phys. Lett. 23: 1084-1087, 2006] is revisited in this study. It is found that the performance of Deng et al.'s protocol can be much improved by using the techniques of block-transmission and decoy single photons. As a result, the qubit efficiency is improved 2.4 times and only one classical communication, a public discussion, and two quantum communications between each agent and the secret holder are needed rather than n classical communications, n public discussions, and 3n/2 quantum communications required in the original scheme.

  9. Efficient Three-Party Quantum Dialogue Protocol Based on the Continuous Variable GHZ States

    NASA Astrophysics Data System (ADS)

    Yu, Zhen-Bo; Gong, Li-Hua; Zhu, Qi-Biao; Cheng, Shan; Zhou, Nan-Run

    2016-07-01

    Based on the continuous variable GHZ entangled states, an efficient three-party quantum dialogue protocol is devised, where each legitimate communication party could simultaneously deduce the secret information of the other two parties with perfect efficiency. The security is guaranteed by the correlation of the continuous variable GHZ entangled states and the randomly selected decoy states. Furthermore, the three-party quantum dialogue protocol is directly generalized to an N-party quantum dialogue protocol by using the n-tuple continuous variable GHZ entangled states.

  10. Demonstration of First 9 Micron cutoff 640 x 486 GaAs Based Quantum Well Infrared PhotoDetector (QWIP) Snap-Shot Camera

    NASA Technical Reports Server (NTRS)

    Gunapala, S.; Bandara, S. V.; Liu, J. K.; Hong, W.; Sundaram, M.; Maker, P. D.; Muller, R. E.

    1997-01-01

    In this paper, we discuss the development of this very sensitive long waelength infrared (LWIR) camera based on a GaAs/AlGaAs QWIP focal plane array (FPA) and its performance in quantum efficiency, NEAT, uniformity, and operability.

  11. Comparison and analysis on test methods of infrared radiant intensity of infrared decoy

    NASA Astrophysics Data System (ADS)

    Chen, Chunsheng; Dai, Mengyan; Liu, Haifeng; Fang, Guofeng; Xie, Changyou; Zhang, Tong

    2014-11-01

    The research on infrared radiant characteristics of typical target is important for the detection and recognition of target, infrared simulation calculation and design of electro-optical countermeasures. Thus it is essential to select appropriate test method and optimal calculation method to improve the test accuracy and reliability of infrared radiant intensity. In this paper, three instruments including SR5000 spectroradiometer (CI, MigdalHaEmek, Israel), remote sensing interferometer spectrometer Tensor37 (Bruker, Germany) and Image IR8325 (InfraTec Ltd, Germany) mid-infrared thermal imager were applied to test the infrared radiant (1μm-3μm - 3μm-5μm) intensity of decoy samples. Three methods were designed based on two operational principles including direct test and indirect test. The SR5000 spectroradiometer which is able to obtain the value of radian intensity immediately is regard as direct test. The other two instruments which deduce and calculate infrared radiant intensity according to Planck's law and Lambert's cosine law with some preliminary tested parameters such as the response voltage - the distribution of infrared radiant temperature of flaming samples and calibrated data by blackbody, however, are regard as indirect test. Reasons for the diversity of experiment results were provided through analysis on the concrete measurement theory and detailed calculation methods. Moreover, some rules and suggestions were put forward to improve the test accuracy and reliability of infrared radiant intensity when different methods were adopted. It is shown from experiment results that the average mid-infrared radiant intensity obtained from SR5000 was about 903W/Sr in near-infrared band - whereas Tensor 37 and Image IR8325 was about 834W/Sr and 547 W/Sr respectively. It was proved that maximum relative of calculated results from remote sensing interferometer spectrometer Tensor37 and results measured with SR5000 spectroradiometer is below 13%, which meet the

  12. Effects of spinning-wing decoys on flock behavior and hunting vulnerability of mallards in Minnesota

    USGS Publications Warehouse

    Szymanski, M.L.; Afton, A.D.

    2005-01-01

    Waterfowl managers in Minnesota and other states are concerned that increased kill rates associated with the use of spinning-wing decoys (SWDs) may negatively affect local breeding populations of mallards (Anas platyrhynchos). Accordingly, we conducted 219 experimental hunts to evaluate hunting vulnerability of mallards to SWDs during the 2002 duck season in Minnesota. During each hunt, we tested 2 SWD treatments: 1) SWDs turned OFF (control), and 2) SWDs turned ON (experimental) during alternate 15-minute sampling periods that were separated by 5-minute buffer periods. We found that mallard flocks (???1 duck) were 2.91 times more likely to respond (i.e., approach within 40 m of hunters), and sizes of responding mallard flocks were 1.25 times larger, on average, when SWDs were turned ON than OFF. Mallards killed/hour/hunter/hunt averaged 4.71 times higher (P < 0.001) when SWDs were turned ON than OFF. More hatch-year (HY) and after-hatch-year (AHY) mallards were killed when SWDs were turned ON than OFF; however, AHYs were relatively less likely than were HYs to be killed with SWDs turned ON. We found no evidence that SWDs reduced crippling or allowed hunters to harvest relatively more drakes than hens. Using a worst-case scenario model, we predicted that if 47% and 79% of Minnesota hunters had used SWDs in 2000 and 2002, respectively, Minnesota mallard harvests would have increased by a factor of 2. However, increasing use of SWDs by northern hunters may result in a partial redistribution of annual mallard harvests if nai??ve ducks are harvested upon initial exposures to SWDs, and those ducks that survive become habituated to SWDs, as suggested by our results. Our study was confined to a single hunting season in Minnesota and thus did not assess whether vulnerability of mallards to hunters using SWDs varied among years or geographically. A multi-year, flyway-wide study is needed to make stronger and more rigorous inferences regarding potential changes in harvest

  13. CSAR Data Set Release 2012: Ligands, Affinities, Complexes, and Docking Decoys

    PubMed Central

    2013-01-01

    A major goal in drug design is the improvement of computational methods for docking and scoring. The Community Structure Activity Resource (CSAR) has collected several data sets from industry and added in-house data sets that may be used for this purpose (www.csardock.org). CSAR has currently obtained data from Abbott, GlaxoSmithKline, and Vertex and is working on obtaining data from several others. Combined with our in-house projects, we are providing a data set consisting of 6 protein targets, 647 compounds with biological affinities, and 82 crystal structures. Multiple congeneric series are available for several targets with a few representative crystal structures of each of the series. These series generally contain a few inactive compounds, usually not available in the literature, to provide an upper bound to the affinity range. The affinity ranges are typically 3–4 orders of magnitude per series. For our in-house projects, we have had compounds synthesized for biological testing. Affinities were measured by Thermofluor, Octet RED, and isothermal titration calorimetry for the most soluble. This allows the direct comparison of the biological affinities for those compounds, providing a measure of the variance in the experimental affinity. It appears that there can be considerable variance in the absolute value of the affinity, making the prediction of the absolute value ill-defined. However, the relative rankings within the methods are much better, and this fits with the observation that predicting relative ranking is a more tractable problem computationally. For those in-house compounds, we also have measured the following physical properties: logD, logP, thermodynamic solubility, and pKa. This data set also provides a substantial decoy set for each target consisting of diverse conformations covering the entire active site for all of the 58 CSAR-quality crystal structures. The CSAR data sets (CSAR-NRC HiQ and the 2012 release) provide substantial, publically

  14. TRAM-Derived Decoy Peptides inhibits the inflammatory response in mouse mammary epithelial cells and a mastitis model in mice.

    PubMed

    Hu, Xiaoyu; Tian, Yuan; Wang, Tiancheng; Zhang, Wenlong; Wang, Wei; Gao, Xuejiao; Qu, Shihui; Cao, Yongguo; Zhang, Naisheng

    2015-10-01

    It has been proved that TRAM-Derived Decoy peptides have anti-inflammatory properties. In this study, we synthesized a TRAM-Derived decoy peptide (TM6), belongs to TRAM TIR domain, of which sequence is "N"-RQIKIWFQNRRMKWK, KENFLRDTWCNFQFY-"C" and evaluated the effects of TM6 on lipopolysaccharide-induced mastitis in mice. In vivo, LPS-induced mice mastitis model was established by injection of LPS through the duct of mammary gland. TM6 was injected 1h before or after LPS treatment. In vitro, primary mouse mammary epithelial cells were used to investigate the effects of TM6 on LPS-induced inflammatory responses. The results showed that TM6 inhibited LPS-induced mammary gland histopathologic changes, MPO activity, and TNF-α, IL-1β and IL-6 production in mice. In vitro, TM6 significantly inhibited LPS-induced TNF-α and IL-6 production, as well as NF-κB and MAPKs activation. In conclusion, this study demonstrated that TM6 had protective effects on LPS-mastitis and may be a promising therapeutic reagent for mastitis treatment.

  15. A PCR-Based Method to Construct Lentiviral Vector Expressing Double Tough Decoy for miRNA Inhibition.

    PubMed

    Qiu, Huiling; Zhong, Jiasheng; Luo, Lan; Liu, Nian; Kang, Kang; Qu, Junle; Peng, Wenda; Gou, Deming

    2015-01-01

    DNA vector-encoded Tough Decoy (TuD) miRNA inhibitor is attracting increased attention due to its high efficiency in miRNA suppression. The current methods used to construct TuD vectors are based on synthesizing long oligonucleotides (~90 mer), which have been costly and problematic because of mutations during synthesis. In this study, we report a PCR-based method for the generation of double Tough Decoy (dTuD) vector in which only two sets of shorter oligonucleotides (< 60 mer) were used. Different approaches were employed to test the inhibitory potency of dTuDs. We demonstrated that dTuD is the most efficient method in miRNA inhibition in vitro and in vivo. Using this method, a mini dTuD library against 88 human miRNAs was constructed and used for a high-throughput screening (HTS) of AP-1 pathway-related miRNAs. Seven miRNAs (miR-18b-5p, -101-3p, -148b-3p, -130b-3p, -186-3p, -187-3p and -1324) were identified as candidates involved in AP-1 pathway regulation. This novel method allows for an accurate and cost-effective generation of dTuD miRNA inhibitor, providing a powerful tool for efficient miRNA suppression in vitro and in vivo. PMID:26624995

  16. A PCR-Based Method to Construct Lentiviral Vector Expressing Double Tough Decoy for miRNA Inhibition

    PubMed Central

    Luo, Lan; Liu, Nian; Kang, Kang; Qu, Junle; Peng, Wenda; Gou, Deming

    2015-01-01

    DNA vector-encoded Tough Decoy (TuD) miRNA inhibitor is attracting increased attention due to its high efficiency in miRNA suppression. The current methods used to construct TuD vectors are based on synthesizing long oligonucleotides (~90 mer), which have been costly and problematic because of mutations during synthesis. In this study, we report a PCR-based method for the generation of double Tough Decoy (dTuD) vector in which only two sets of shorter oligonucleotides (< 60 mer) were used. Different approaches were employed to test the inhibitory potency of dTuDs. We demonstrated that dTuD is the most efficient method in miRNA inhibition in vitro and in vivo. Using this method, a mini dTuD library against 88 human miRNAs was constructed and used for a high-throughput screening (HTS) of AP-1 pathway-related miRNAs. Seven miRNAs (miR-18b-5p, -101-3p, -148b-3p, -130b-3p, -186-3p, -187-3p and -1324) were identified as candidates involved in AP-1 pathway regulation. This novel method allows for an accurate and cost-effective generation of dTuD miRNA inhibitor, providing a powerful tool for efficient miRNA suppression in vitro and in vivo. PMID:26624995

  17. Barrier infrared detector research at the Jet Propulsion Laboratory

    NASA Astrophysics Data System (ADS)

    Ting, David Z.; Keo, Sam A.; Liu, John K.; Mumolo, Jason M.; Khoshakhlagh, Arezou; Soibel, Alexander; Nguyen, Jean; Höglund, Linda; Rafol, B., , Sir; Hill, Cory J.; Gunapala, Sarath D.

    2012-10-01

    The barrier infrared detector device architecture offers the advantage of reduced dark current resulting from suppressed Shockley-Read-Hall (SRH) recombination and surface leakage. The versatility of the antimonide material system, with the availability of three different types of band offsets for flexibility in device design, provides the ideal setting for implementing barrier infrared detectors. We describe the progress made at the NASA Jet Propulsion Laboratory in recent years in Barrier infrared detector research that resulted in high-performance quantum structure infrared detectors, including the type-II superlattice complementary barrier infrared detector (CBIRD), and the high operating quantum dot barrier infrared detector (HOT QD-BIRD).

  18. Detector requirements for space infrared astronomy

    NASA Technical Reports Server (NTRS)

    Wright, E. L.

    1986-01-01

    Requirements for background-limited (BLIP) detectors are discussed in terms of number of photons falling on each pixel, dark current, high detective quantum efficiencies, large numbers of pixels, and array size.

  19. Requirements on high resolution detectors

    SciTech Connect

    Koch, A.

    1997-02-01

    For a number of microtomography applications X-ray detectors with a spatial resolution of 1 {mu}m are required. This high spatial resolution will influence and degrade other parameters of secondary importance like detective quantum efficiency (DQE), dynamic range, linearity and frame rate. This note summarizes the most important arguments, for and against those detector systems which could be considered. This article discusses the mutual dependencies between the various figures which characterize a detector, and tries to give some ideas on how to proceed in order to improve present technology.

  20. TRAIL upregulates decoy receptor 1 and mediates resistance to apoptosis in insulin-secreting INS-1 cells.

    PubMed

    Kang, Soojeong; Park, So-Young; Lee, Hye-Jeong; Yoo, Young Hyun

    2010-06-01

    TRAIL/Apo2L (tumor necrosis factor-related apoptosis-inducing ligand) is a multifunctional protein regulating the homeostasis of the immune system, infection, autoimmune diseases, and apoptosis. In particular, the potential role of TRAIL in type 1 diabetes (T1D) has been studied by several research groups. A previous study found that TRAIL did not have significant cytotoxic effects on the insulin-secreting pancreatic beta cell line, INS-1. However, the mechanism was not clear. Here we demonstrate that INS-1 cells are resistant to TRAIL-induced apoptosis and show alteration in the expression of death and decoy receptors upon TRAIL treatment. To compare TRAIL-resistant INS-1 cells with TRAIL-sensitive cells, we utilized U87MG cells, which are known to be TRAIL-sensitive. TRAIL treatment showed NF-kappaB translocation to the nucleus in TRAIL-resistant INS-1 cells, and TRAIL-induced NF-kappaB activation was preceded by IkappaBalpha degradation. A pharmacological inhibitor of NF-kappaB, Bay 11-7082, blocked TRAIL-induced NF-kappaB translocation to the nucleus and IkappaBalpha degradation. Four related receptors bind TRAIL: two death receptors (DR4 and DR5) that promote apoptosis, and two decoy receptors (DcR1 and DcR2) that act as dominant-negative inhibitors of TRAIL-mediated apoptosis. In the present study, TRAIL treatment in INS-1 cells upregulated DcR1 and downregulated DR5 without altering the expression of DcR2 and DR4. The resistance to apoptosis in INS-1 cells might therefore, be a consequence of DcR1 upregulation and DR5 downregulation, and the transcription factor, NF-kappaB, could regulate the sensitivity of cells to TRAIL by controlling the ratio of decoy to death receptors. Thus, TRAIL may play an important role in the survival of pancreatic beta cells by regulating receptor expression in an NF-kappaB-dependent manner.

  1. Potential use of fucose-appended dendrimer/α-cyclodextrin conjugates as NF-κB decoy carriers for the treatment of lipopolysaccharide-induced fulminant hepatitis in mice.

    PubMed

    Akao, Chiho; Tanaka, Takahiro; Onodera, Risako; Ohyama, Ayumu; Sato, Nana; Motoyama, Keiichi; Higashi, Taishi; Arima, Hidetoshi

    2014-11-10

    The purpose of the present study is to treat lipopolysaccharide (LPS)-induced fulminant hepatitis by NF-κB decoy complex with fucose-appended dendrimer (generation 2; G2) conjugate with α-cyclodextrin (Fuc-S-α-CDE (G2)). Fuc-S-α-CDE (G2, average degree of substitution of fucose (DSF2))/NF-κB decoy complex significantly suppressed nitric oxide and tumor necrosis factor-α (TNF-α) production from LPS-stimulated NR8383 cells, a rat alveolar macrophage cell line, by adequate physicochemical properties and fucose receptor-mediated cellular uptake. Intravenous injection of Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex extended the survival of LPS-induced fulminant hepatitis model mice. In addition, Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex administered intravenously highly accumulated in the liver, compared to naked NF-κB decoy alone. Furthermore, the liver accumulation of Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex was inhibited by the pretreatment with GdCl3, a specific inhibitor of Kupffer cell uptake. Also, the serum aspartate aminotransferase, alanine aminotransferase and TNF-α levels in LPS-induced fulminant hepatitis model mice were significantly attenuated by the treatment with Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex, compared with naked NF-κB decoy alone. Taken together, these results suggest that Fuc-S-α-CDE (G2, DSF2) has the potential for a novel Kupffer cell-selective NF-κB decoy carrier for the treatment of LPS-induced fulminant hepatitis in mice. PMID:25020038

  2. Potential use of fucose-appended dendrimer/α-cyclodextrin conjugates as NF-κB decoy carriers for the treatment of lipopolysaccharide-induced fulminant hepatitis in mice.

    PubMed

    Akao, Chiho; Tanaka, Takahiro; Onodera, Risako; Ohyama, Ayumu; Sato, Nana; Motoyama, Keiichi; Higashi, Taishi; Arima, Hidetoshi

    2014-11-10

    The purpose of the present study is to treat lipopolysaccharide (LPS)-induced fulminant hepatitis by NF-κB decoy complex with fucose-appended dendrimer (generation 2; G2) conjugate with α-cyclodextrin (Fuc-S-α-CDE (G2)). Fuc-S-α-CDE (G2, average degree of substitution of fucose (DSF2))/NF-κB decoy complex significantly suppressed nitric oxide and tumor necrosis factor-α (TNF-α) production from LPS-stimulated NR8383 cells, a rat alveolar macrophage cell line, by adequate physicochemical properties and fucose receptor-mediated cellular uptake. Intravenous injection of Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex extended the survival of LPS-induced fulminant hepatitis model mice. In addition, Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex administered intravenously highly accumulated in the liver, compared to naked NF-κB decoy alone. Furthermore, the liver accumulation of Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex was inhibited by the pretreatment with GdCl3, a specific inhibitor of Kupffer cell uptake. Also, the serum aspartate aminotransferase, alanine aminotransferase and TNF-α levels in LPS-induced fulminant hepatitis model mice were significantly attenuated by the treatment with Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex, compared with naked NF-κB decoy alone. Taken together, these results suggest that Fuc-S-α-CDE (G2, DSF2) has the potential for a novel Kupffer cell-selective NF-κB decoy carrier for the treatment of LPS-induced fulminant hepatitis in mice.

  3. Inconclusive quantum measurements and decisions under uncertainty

    NASA Astrophysics Data System (ADS)

    Yukalov, Vyacheslav; Sornette, Didier

    2016-04-01

    We give a mathematical definition for the notion of inconclusive quantum measurements. In physics, such measurements occur at intermediate stages of a complex measurement procedure, with the final measurement result being operationally testable. Since the mathematical structure of Quantum Decision Theory has been developed in analogy with the theory of quantum measurements, the inconclusive quantum measurements correspond, in Quantum Decision Theory, to intermediate stages of decision making in the process of taking decisions under uncertainty. The general form of the quantum probability for a composite event is the sum of a utility factor, describing a rational evaluation of the considered prospect, and of an attraction factor, characterizing irrational, subconscious attitudes of the decision maker. Despite the involved irrationality, the probability of prospects can be evaluated. This is equivalent to the possibility of calculating quantum probabilities without specifying hidden variables. We formulate a general way of evaluation, based on the use of non-informative priors. As an example, we suggest the explanation of the decoy effect. Our quantitative predictions are in very good agreement with experimental data.

  4. A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB

    PubMed Central

    2011-01-01

    Background The transcription factor STAT3 (signal transducer and activator of transcription 3) is frequently activated in tumor cells. Activated STAT3 forms homodimers, or heterodimers with other TFs such as NF-κB, which becomes activated. Cytoplasmic STAT3 dimers are activated by tyrosine phosphorylation; they interact with importins via a nuclear localization signal (NLS) one of which is located within the DNA-binding domain formed by the dimer. In the nucleus, STAT3 regulates target gene expression by binding a consensus sequence within the promoter. STAT3-specific decoy oligonucleotides (STAT3-decoy ODN) that contain this consensus sequence inhibit the transcriptional activity of STAT3, leading to cell death; however, their mechanism of action is unclear. Results The mechanism of action of a STAT3-decoy ODN was analyzed in the colon carcinoma cell line SW 480. These cells' dependence on activated STAT3 was verified by showing that cell death is induced by STAT3-specific siRNAs or Stattic. STAT3-decoy ODN was shown to bind activated STAT3 within the cytoplasm, and to prevent its translocation to the nucleus, as well as that of STAT3-associated NF-κB, but it did not prevent the nuclear transfer of STAT3 with mutations in its DNA-binding domain. The complex formed by STAT3 and the STAT3-decoy ODN did not associate with importin, while STAT3 alone was found to co-immunoprecipitate with importin. Leptomycin B and vanadate both trap STAT3 in the nucleus. They were found here to oppose the cytoplasmic trapping of STAT3 by the STAT3-decoy ODN. Control decoys consisting of either a mutated STAT3-decoy ODN or a NF-κB-specific decoy ODN had no effect on STAT3 nuclear translocation. Finally, blockage of STAT3 nuclear transfer correlated with the induction of SW 480 cell death. Conclusions The inhibition of STAT3 by a STAT3-decoy ODN, leading to cell death, involves the entrapment of activated STAT3 dimers in the cytoplasm. A mechanism is suggested whereby this

  5. Smoke Detector

    NASA Technical Reports Server (NTRS)

    1979-01-01

    In the photo, Fire Chief Jay Stout of Safety Harbor, Florida, is explaining to young Richard Davis the workings of the Honeywell smoke and fire detector which probably saved Richard's life and that of his teen-age brother. Alerted by the detector's warning, the pair were able to escape their burning home. The detector in the Davis home was one of 1,500 installed in Safety Harbor residences in a cooperative program conducted by the city and Honeywell Inc.

  6. Human NgR-Fc Decoy Protein via Lumbar Intrathecal Bolus Administration Enhances Recovery from Rat Spinal Cord Contusion

    PubMed Central

    Wang, Xingxing; Yigitkanli, Kazim; Kim, Chang-Yeon; Sekine-Komo, Tomoko; Wirak, Dana; Frieden, Eric; Bhargava, Ajay; Maynard, George; Cafferty, William B.J.

    2014-01-01

    Abstract Axonal growth and neurological recovery after traumatic spinal cord injury (SCI) is limited by the presence of inhibitory proteins in myelin, several of which act via the NgR1 protein in neurons. A truncated soluble ligand-binding fragment of NgR1 serves as a decoy and promotes recovery in acute and chronic rodent SCI models. To develop the translational potential of these observations, we created a human sequence-derived NgR1(310)-Fc protein. This protein is active in vitro. When the human NgR1 decoy is administered by continuous intracerebroventricular infusion to rats with a spinal contusion injury at doses of 0.09–0.53 mg/kg/d, neurological recovery is improved. Effective doses double the percentage of rats able to bear weight on their hindlimbs. Next, we considered the half-life and distribution of NgR1(310)-Fc after bolus delivery to the lumbar intrathecal space. The protein is found throughout the neuraxis and has a tissue half-life of approximately 2 days in the rat, and 5 days in the nonhuman primate. At an intermittent, once every 4 day, lumbar bolus dosing schedule of 0.14 mg/kg/d, NgR1(310)-Fc promoted locomotor rat recovery from spinal cord contusion at least as effectively as continuous infusion in open field and grid walking tasks. Moreover, the intermittent lumbar NgR1(310)-Fc treatment increased the growth of raphespinal axons into the lumbar spinal cord after injury. Thus, human NgR1(310)-Fc provides effective treatment for recovery from traumatic SCI in this preclinical model with a simplified administration regimen that facilitates clinical testing. PMID:24964223

  7. Sorting quantum systems efficiently.

    PubMed

    Ionicioiu, Radu

    2016-01-01

    Measuring the state of a quantum system is a fundamental process in quantum mechanics and plays an essential role in quantum information and quantum technologies. One method to measure a quantum observable is to sort the system in different spatial modes according to the measured value, followed by single-particle detectors on each mode. Examples of quantum sorters are polarizing beam-splitters (PBS) - which direct photons according to their polarization - and Stern-Gerlach devices. Here we propose a general scheme to sort a quantum system according to the value of any d-dimensional degree of freedom, such as spin, orbital angular momentum (OAM), wavelength etc. Our scheme is universal, works at the single-particle level and has a theoretical efficiency of 100%. As an application we design an efficient OAM sorter consisting of a single multi-path interferometer which is suitable for a photonic chip implementation. PMID:27142705

  8. Sorting quantum systems efficiently

    NASA Astrophysics Data System (ADS)

    Ionicioiu, Radu

    2016-05-01

    Measuring the state of a quantum system is a fundamental process in quantum mechanics and plays an essential role in quantum information and quantum technologies. One method to measure a quantum observable is to sort the system in different spatial modes according to the measured value, followed by single-particle detectors on each mode. Examples of quantum sorters are polarizing beam-splitters (PBS) – which direct photons according to their polarization – and Stern-Gerlach devices. Here we propose a general scheme to sort a quantum system according to the value of any d-dimensional degree of freedom, such as spin, orbital angular momentum (OAM), wavelength etc. Our scheme is universal, works at the single-particle level and has a theoretical efficiency of 100%. As an application we design an efficient OAM sorter consisting of a single multi-path interferometer which is suitable for a photonic chip implementation.

  9. Sorting quantum systems efficiently

    PubMed Central

    Ionicioiu, Radu

    2016-01-01

    Measuring the state of a quantum system is a fundamental process in quantum mechanics and plays an essential role in quantum information and quantum technologies. One method to measure a quantum observable is to sort the system in different spatial modes according to the measured value, followed by single-particle detectors on each mode. Examples of quantum sorters are polarizing beam-splitters (PBS) – which direct photons according to their polarization – and Stern-Gerlach devices. Here we propose a general scheme to sort a quantum system according to the value of any d-dimensional degree of freedom, such as spin, orbital angular momentum (OAM), wavelength etc. Our scheme is universal, works at the single-particle level and has a theoretical efficiency of 100%. As an application we design an efficient OAM sorter consisting of a single multi-path interferometer which is suitable for a photonic chip implementation. PMID:27142705

  10. Comment on "Quantum oblivious set-member decision protocol"

    NASA Astrophysics Data System (ADS)

    Liu, Bin; Xiao, Di; Huang, Wei; Song, Ting-Ting

    2016-03-01

    In a recent paper [Phys. Rev. A 92, 022309 (2015), 10.1103/PhysRevA.92.022309], the authors proposed a quantum oblivious set-member decision protocol, which is designed to allow a server to check whether a private secret of a user is a member of his private set in an oblivious manner. Such protocols should protect the privacies of both the server and the user. However, we find that the user in their protocol can steal l -1 bits of information about the server's private set by sending the false decoy states.

  11. Optical Detectors

    NASA Astrophysics Data System (ADS)

    Goushcha, Alexander; Tabbert, Bernd

    Optical detectors are applied in all fields of human activities - from basic research to commercial applications in communication, automotive, medical imaging, homeland security, and other fields. The processes of light interaction with matter described in other chapters of this handbook form the basis for understanding the optical detectors physics and device properties.

  12. Optical Detectors

    NASA Astrophysics Data System (ADS)

    Tabbert, Bernd; Goushcha, Alexander

    Optical detectors are applied in all fields of human activities from basic research to commercial applications in communication, automotive, medical imaging, homeland security, and other fields. The processes of light interaction with matter described in other chapters of this handbook form the basis for understanding the optical detectors physics and device properties.

  13. Continuous-variable quantum-key-distribution protocols with a non-Gaussian modulation

    SciTech Connect

    Leverrier, Anthony; Grangier, Philippe

    2011-04-15

    In this paper, we consider continuous-variable quantum-key-distribution (QKD) protocols which use non-Gaussian modulations. These specific modulation schemes are compatible with very efficient error-correction procedures, hence allowing the protocols to outperform previous protocols in terms of achievable range. In their simplest implementation, these protocols are secure for any linear quantum channels (hence against Gaussian attacks). We also show how the use of decoy states makes the protocols secure against arbitrary collective attacks, which implies their unconditional security in the asymptotic limit.

  14. Gaseous Detectors

    NASA Astrophysics Data System (ADS)

    Titov, Maxim

    Since long time, the compelling scientific goals of future high-energy physics experiments were a driving factor in the development of advanced detector technologies. A true innovation in detector instrumentation concepts came in 1968, with the development of a fully parallel readout for a large array of sensing elements - the Multi-Wire Proportional Chamber (MWPC), which earned Georges Charpak a Nobel prize in physics in 1992. Since that time radiation detection and imaging with fast gaseous detectors, capable of economically covering large detection volumes with low mass budget, have been playing an important role in many fields of physics. Advances in photolithography and microprocessing techniques in the chip industry during the past decade triggered a major transition in the field of gas detectors from wire structures to Micro-Pattern Gas Detector (MPGD) concepts, revolutionizing cell-size limitations for many gas detector applications. The high radiation resistance and excellent spatial and time resolution make them an invaluable tool to confront future detector challenges at the next generation of colliders. The design of the new micro-pattern devices appears suitable for industrial production. Novel structures where MPGDs are directly coupled to the CMOS pixel readout represent an exciting field allowing timing and charge measurements as well as precise spatial information in 3D. Originally developed for the high-energy physics, MPGD applications have expanded to nuclear physics, photon detection, astroparticle and neutrino physics, neutron detection, and medical imaging.

  15. Moderate temperature detector development

    NASA Technical Reports Server (NTRS)

    Marciniec, J. W.; Briggs, R. J.; Sood, A. K.

    1981-01-01

    P-side backside reflecting constant, photodiode characterization, and photodiode diffusion and G-R currents were investigated in an effort to develop an 8 m to 12 m infrared quantum detector using mercury cadmium telluride. Anodization, phosphorus implantation, and the graded band gap concept were approaches considered for backside formation. Variable thickness diodes were fabricated with a back surface anodic oxide to investigate the effect of this surface preparation on the diffusion limited zero bias impedance. A modeling technique was refined to thoroughly model diode characteristics. Values for the surface recombination velocity in the depletion region were obtained. These values were improved by implementing better surface damage removal techniques.

  16. Ab initio structure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector

    PubMed Central

    van Genderen, E.; Clabbers, M. T. B.; Das, P. P.; Stewart, A.; Nederlof, I.; Barentsen, K. C.; Portillo, Q.; Pannu, N. S.; Nicolopoulos, S.; Gruene, T.; Abrahams, J. P.

    2016-01-01

    Until recently, structure determination by transmission electron microscopy of beam-sensitive three-dimensional nanocrystals required electron diffraction tomography data collection at liquid-nitrogen temperature, in order to reduce radiation damage. Here it is shown that the novel Timepix detector combines a high dynamic range with a very high signal-to-noise ratio and single-electron sensitivity, enabling ab initio phasing of beam-sensitive organic compounds. Low-dose electron diffraction data (∼0.013 e− Å−2 s−1) were collected at room temperature with the rotation method. It was ascertained that the data were of sufficient quality for structure solution using direct methods using software developed for X-ray crystallography (XDS, SHELX) and for electron crystallography (ADT3D/PETS, SIR2014). PMID:26919375

  17. Ab initio structure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector.

    PubMed

    van Genderen, E; Clabbers, M T B; Das, P P; Stewart, A; Nederlof, I; Barentsen, K C; Portillo, Q; Pannu, N S; Nicolopoulos, S; Gruene, T; Abrahams, J P

    2016-03-01

    Until recently, structure determination by transmission electron microscopy of beam-sensitive three-dimensional nanocrystals required electron diffraction tomography data collection at liquid-nitrogen temperature, in order to reduce radiation damage. Here it is shown that the novel Timepix detector combines a high dynamic range with a very high signal-to-noise ratio and single-electron sensitivity, enabling ab initio phasing of beam-sensitive organic compounds. Low-dose electron diffraction data (∼ 0.013 e(-) Å(-2) s(-1)) were collected at room temperature with the rotation method. It was ascertained that the data were of sufficient quality for structure solution using direct methods using software developed for X-ray crystallography (XDS, SHELX) and for electron crystallography (ADT3D/PETS, SIR2014). PMID:26919375

  18. MS Detectors

    SciTech Connect

    Koppenaal, David W.; Barinaga, Charles J.; Denton, M Bonner B.; Sperline, Roger P.; Hieftje, Gary M.; Schilling, G. D.; Andrade, Francisco J.; Barnes IV., James H.

    2005-11-01

    Good eyesight is often taken for granted, a situation that everyone appreciates once vision begins to fade with age. New eyeglasses or contact lenses are traditional ways to improve vision, but recent new technology, i.e. LASIK laser eye surgery, provides a new and exciting means for marked vision restoration and improvement. In mass spectrometry, detectors are the 'eyes' of the MS instrument. These 'eyes' have also been taken for granted. New detectors and new technologies are likewise needed to correct, improve, and extend ion detection and hence, our 'chemical vision'. The purpose of this report is to review and assess current MS detector technology and to provide a glimpse towards future detector technologies. It is hoped that the report will also serve to motivate interest, prompt ideas, and inspire new visions for ion detection research.

  19. Signal Peptide Cleavage from GP5 of PRRSV: A Minor Fraction of Molecules Retains the Decoy Epitope, a Presumed Molecular Cause for Viral Persistence

    PubMed Central

    Thaa, Bastian; Sinhadri, Balaji Chandrasekhar; Tielesch, Claudia; Krause, Eberhard; Veit, Michael

    2013-01-01

    Porcine reproductive and respiratory syndrome virus (PRRSV) is the major pathogen in the pig industry. Variability of the antigens and persistence are the biggest challenges for successful control and elimination of the disease. GP5, the major glycoprotein of PRRSV, is considered an important target of neutralizing antibodies, which however appear only late in infection. This was attributed to the presence of a “decoy epitope” located near a hypervariable region of GP5. This region also harbors the predicted signal peptide cleavage sites and (dependent on the virus strain) a variable number of potential N-glycosylation sites. Molecular processing of GP5 has not been addressed experimentally so far: whether and where the signal peptide is cleaved and (as a consequence) whether the “decoy epitope” is present in virus particles. We show that the signal peptide of GP5 from the American type 2 reference strain VR-2332 is cleaved, both during in vitro translation in the presence of microsomes and in transfected cells. This was found to be independent of neighboring glycosylation sites and occurred in a variety of porcine cells for GP5 sequences derived from various type 2 strains. The exact signal peptide cleavage site was elucidated by mass spectrometry of virus-derived and recombinant GP5. The results revealed that the signal peptide of GP5 is cleaved at two sites. As a result, a mixture of GP5 proteins exists in virus particles, some of which still contain the “decoy epitope” sequence. Heterogeneity was also observed for the use of glycosylation sites in the hypervariable region. Lastly, GP5 mutants were engineered where one of the signal peptide cleavage sites was blocked. Wildtype GP5 exhibited exactly the same SDS-PAGE mobility as the mutant that is cleavable at site 2 only. This indicates that the overwhelming majority of all GP5 molecules does not contain the “decoy epitope”. PMID:23755249

  20. Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

    PubMed

    O'Leary, L; van der Sloot, A M; Reis, C R; Deegan, S; Ryan, A E; Dhami, S P S; Murillo, L S; Cool, R H; Correa de Sampaio, P; Thompson, K; Murphy, G; Quax, W J; Serrano, L; Samali, A; Szegezdi, E

    2016-03-10

    Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a death ligand cytokine known for its cytotoxic activity against malignantly transformed cells. TRAIL induces cell death through binding to death receptors DR4 and DR5. The inhibitory decoy receptors (DcR1 and DcR2) co-expressed with death receptor 4 (DR4)/DR5 on the same cell can block the transmission of the apoptotic signal. Here, we show that DcRs also regulate TRAIL sensitivity at a supracellular level and thus represent a mechanism by which the microenvironment can diminish tumour TRAIL sensitivity. Mathematical modelling and layered or spheroid stroma-extracellular matrix-tumour cultures were used to model the tumour microenvironment. By engineering TRAIL to escape binding by DcRs, we found that DcRs do not only act in a cell-autonomous or cis-regulatory manner, but also exert trans-cellular regulation originating from stromal cells and affect tumour cells, highlighting the potent inhibitory effect of DcRs in the tumour tissue and the necessity of selective targeting of the two death-inducing TRAIL receptors to maximise efficacy. PMID:26050621

  1. Pyroelectric detectors

    NASA Technical Reports Server (NTRS)

    Haller, Eugene E.; Beeman, Jeffrey; Hansen, William L.; Hubbard, G. Scott; Mcmurray, Robert E., Jr.

    1990-01-01

    The multi-agency, long-term Global Change programs, and specifically NASA's Earth Observing system, will require some new and advanced photon detector technology which must be specifically tailored for long-term stability, broad spectral range, cooling constraints, and other parameters. Whereas MCT and GaAs alloy based photovoltaic detectors and detector arrays reach most impressive results to wavelengths as long as 12 microns when cooled to below 70 K, other materials, such as ferroelectrics and pyroelectrics, appear to offer special opportunities beyond 12 microns and above 70 K. These materials have found very broad use in a wide variety of room temperature applications. Little is known about these classes of materials at sub-room temperatures and no photon detector results have been reported. From the limited information available, researchers conclude that the room temperature values of D asterisk greater than or equal to 10(exp 9) cm Hz(exp 1/2)/W may be improved by one to two orders of magnitude upon cooling to temperatures around 70 K. Improvements of up to one order of magnitude appear feasible for temperatures achievable by passive cooling. The flat detector response over a wavelength range reaching from the visible to beyond 50 microns, which is an intrinsic advantage of bolometric devices, makes for easy calibration. The fact that these materials have been developed for reduced temperature applications makes ferro- and pyroelectric materials most attractive candidates for serious exploration.

  2. The theory and experiment of very-long-wavelength 256×1 GaAs/Al x Ga1- x As quantum well infrared detector linear arrays

    NASA Astrophysics Data System (ADS)

    Guo, Fangmin; Li, Ning; Xiong, Dayuan; Zhen, Honglou; Xu, Xiangyan; Hou, Ying; Ding, Ruijun; Lu, Wei; Huang, Qi; Zhou, Junming

    2008-07-01

    The 256×1 linear array of multiple quantum wells infrared photodetector (QWIP) is designed and fabricated for the peak response wavelength at λ P = 14.6 μm. The response spectral width is bigger than 2.2 μm. The two-dimensional (2D) diffractive coupling grating has been formed on the top QWIP photosensitive pixel for coupling the infrared radiation to the infrared detective layers. The performance of the device at V B = 3 V and T = 45 K has the responsibility 4.28×10-2 (A/W), the blackbody detectivity D b* = 5.14×109 (cm·Hz1/2/W), and the peak detectivity D λ * = 4.24× 1010 (cm·Hz1/2/W). The sensor pixels are connected with CMOS read out circuit (ROC) hybridization by indium bumps. When integral time is 100 μs, the linear array has the effective pixel of QWIP FPA N ef of 99.2%, the average responsibility overline R (V/W) of 3.48×106 (V/W), the average peak detectivity D λ * of 8.29×109 (cm·Hz1/2/W), and the non-uniformity UR of 5.83%. This device is ready for the thermal image application.

  3. PHASE DETECTOR

    DOEpatents

    Kippenhan, D.O.

    1959-09-01

    A phase detector circuit is described for use at very high frequencies of the order of 50 megacycles. The detector circuit includes a pair of rectifiers inverted relative to each other. One voltage to be compared is applied to the two rectifiers in phase opposition and the other voltage to be compared is commonly applied to the two rectifiers. The two result:ng d-c voltages derived from the rectifiers are combined in phase opposition to produce a single d-c voltage having amplitude and polarity characteristics dependent upon the phase relation between the signals to be compared. Principal novelty resides in the employment of a half-wave transmission line to derive the phase opposing signals from the first voltage to be compared for application to the two rectifiers in place of the transformer commonly utilized for such purpose in phase detector circuits for operation at lower frequency.

  4. Hydrogen detector

    DOEpatents

    Kanegae, Naomichi; Ikemoto, Ichiro

    1980-01-01

    A hydrogen detector of the type in which the interior of the detector is partitioned by a metal membrane into a fluid section and a vacuum section. Two units of the metal membrane are provided and vacuum pipes are provided independently in connection to the respective units of the metal membrane. One of the vacuum pipes is connected to a vacuum gauge for static equilibrium operation while the other vacuum pipe is connected to an ion pump or a set of an ion pump and a vacuum gauge both designed for dynamic equilibrium operation.

  5. Microwave detector

    DOEpatents

    Meldner, Heiner W.; Cusson, Ronald Y.; Johnson, Ray M.

    1986-01-01

    A microwave detector (10) is provided for measuring the envelope shape of a microwave pulse comprised of high-frequency oscillations. A biased ferrite (26, 28) produces a magnetization field flux that links a B-dot loop (16, 20). The magnetic field of the microwave pulse participates in the formation of the magnetization field flux. High-frequency insensitive means (18, 22) are provided for measuring electric voltage or current induced in the B-dot loop. The recorded output of the detector is proportional to the time derivative of the square of the envelope shape of the microwave pulse.

  6. Microwave detector

    DOEpatents

    Meldner, H.W.; Cusson, R.Y.; Johnson, R.M.

    1985-02-08

    A microwave detector is provided for measuring the envelope shape of a microwave pulse comprised of high-frequency oscillations. A biased ferrite produces a magnetization field flux that links a B-dot loop. The magnetic field of the microwave pulse participates in the formation of the magnetization field flux. High-frequency insensitive means are provided for measuring electric voltage or current induced in the B-dot loop. The recorded output of the detector is proportional to the time derivative of the square of the envelope shape of the microwave pulse.

  7. Silicon Detectors

    NASA Astrophysics Data System (ADS)

    Sadrozinski, Hartmut

    2014-03-01

    The use of silicon detectors has experienced an exponential growth in accelerator and space based experiments, similar to trends in the semiconductor industry as a whole, usually paraphrased as ``Moore's Law.'' Some of the essentials for this phenomenon will be presented, together with examples of the exciting science results which it enabled. With the establishment of a ``semiconductor culture'' in universities and laboratories around the world, an increased understanding of the sensors results in thinner, faster, more radiation-resistant detectors, spawning an amazing wealth of new technologies and applications, which will be the main subject of the presentation.

  8. Microwave detector

    SciTech Connect

    Meldner, H.W.; Cusson, R.Y.; Johnson, R.M.

    1986-12-02

    A detector is described for measuring the envelope shape of a microwave pulse comprised of high-frequency oscillations, the detector comprising: a B-dot loop linking the magnetic field of the microwave pulse; a biased ferrite, that produces a magnetization field flux that links the B-dot loop. The ferrite is positioned within the B-dot loop so that the magnetic field of the microwave pulse interacts with the ferrite and thereby participates in the formation of the magnetization field flux; and high-frequency insensitive means for measuring electric voltage or current induced in the B-dot loop.

  9. Ultra fast quantum key distribution over a 97 km installed telecom fiber with wavelength division multiplexing clock synchronization.

    PubMed

    Tanaka, Akihiro; Fujiwara, Mikio; Nam, Sae W; Nambu, Yoshihiro; Takahashi, Seigo; Maeda, Wakako; Yoshino, Ken-ichiro; Miki, Shigehito; Baek, Burm; Wang, Zhen; Tajima, Akio; Sasaki, Masahide; Tomita, Akihisa

    2008-07-21

    We demonstrated ultra fast BB84 quantum key distribution (QKD) transmission at 625 MHz clock rate through a 97 km field-installed fiber using practical clock synchronization based on wavelength-division multiplexing (WDM). We succeeded in over-one-hour stable key generation at a high sifted key rate of 2.4 kbps and a low quantum bit error rate (QBER) of 2.9%. The asymptotic secure key rate was estimated to be 0.78- 0.82 kbps from the transmission data with the decoy method of average photon numbers 0, 0.15, and 0.4 photons/pulse. PMID:18648454

  10. Coherent detectors

    NASA Astrophysics Data System (ADS)

    Lawrence, C. R.; Church, S.; Gaier, T.; Lai, R.; Ruf, C.; Wollack, E.

    2009-03-01

    Coherent systems offer significant advantages in simplicity, testability, control of systematics, and cost. Although quantum noise sets the fundamental limit to their performance at high frequencies, recent breakthroughs suggest that near-quantum-limited noise up to 150 or even 200 GHz could be realized within a few years. If the demands of component separation can be met with frequencies below 200 GHz, coherent systems will be strong competitors for a space CMB polarization mission. The rapid development of digital correlator capability now makes space interferometers with many hundreds of elements possible. Given the advantages of coherent interferometers in suppressing systematic effects, such systems deserve serious study.

  11. Vertex detectors

    SciTech Connect

    Lueth, V.

    1992-07-01

    The purpose of a vertex detector is to measure position and angles of charged particle tracks to sufficient precision so as to be able to separate tracks originating from decay vertices from those produced at the interaction vertex. Such measurements are interesting because they permit the detection of weakly decaying particles with lifetimes down to 10{sup {minus}13} s, among them the {tau} lepton and charm and beauty hadrons. These two lectures are intended to introduce the reader to the different techniques for the detection of secondary vertices that have been developed over the past decades. The first lecture includes a brief introduction to the methods used to detect secondary vertices and to estimate particle lifetimes. It describes the traditional technologies, based on photographic recording in emulsions and on film of bubble chambers, and introduces fast electronic registration of signals derived from scintillating fibers, drift chambers and gaseous micro-strip chambers. The second lecture is devoted to solid state detectors. It begins with a brief introduction into semiconductor devices, and then describes the application of large arrays of strip and pixel diodes for charged particle tracking. These lectures can only serve as an introduction the topic of vertex detectors. Time and space do not allow for an in-depth coverage of many of the interesting aspects of vertex detector design and operation.

  12. Nonlinearity in single photon detection: modeling and quantum tomography.

    PubMed

    Akhlaghi, Mohsen K; Majedi, A Hamed; Lundeen, Jeff S

    2011-10-24

    Single Photon Detectors are integral to quantum optics and quantum information. Superconducting Nanowire based detectors exhibit new levels of performance, but have no accepted quantum optical model that is valid for multiple input photons. By performing Detector Tomography, we improve the recently proposed model [M.K. Akhlaghi and A.H. Majedi, IEEE Trans. Appl. Supercond. 19, 361 (2009)] and also investigate the manner in which these detectors respond nonlinearly to light, a valuable feature for some applications. We develop a device independent model for Single Photon Detectors that incorporates this nonlinearity. PMID:22108981

  13. Photonic quantum technologies

    NASA Astrophysics Data System (ADS)

    O'Brien, Jeremy

    2013-03-01

    Of the approaches to quantum computing, photons are appealing for their low-noise properties and ease of manipulation, and relevance to other quantum technologies, including communication, metrology and measurement. We report an integrated waveguide approach to photonic quantum circuits for high performance, miniaturization and scalability [6-10]. We address the challenges of scaling up quantum circuits using new insights into how controlled operations can be efficiently realised, demonstrating Shor's algorithm with consecutive CNOT gates and the iterative phase estimation algorithm. We have shown how quantum circuits can be reconfigured, using thermo-optic phase shifters to realise a highly reconfigurable quantum circuit, and electro-optic phase shifters in lithium niobate to rapidly manipulate the path and polarisation of telecomm wavelength single photons. We have addressed miniaturisation using multimode interference architectures to directly implement NxN Hadamard operations, and by using high refractive index contrast materials such as SiOxNy, in which we have implemented quantum walks of correlated photons, and Si, in which we have demonstrated generation of orbital angular momentum states of light. We have incorporated microfluidic channels for the delivery of samples to measure the concentration of a blood protein with entangled states of light. We have begun to address the integration of superconducting single photon detectors and diamond and non-linear single photon sources. Finally, we give an overview of recent work on fundamental aspects of quantum measurement, including a quantum version of Wheeler's delayed choice experiment.

  14. Quantum state sharing against the controller's cheating

    NASA Astrophysics Data System (ADS)

    Shi, Run-hua; Zhong, Hong; Huang, Liu-sheng

    2013-08-01

    Most existing QSTS schemes are equivalent to the controlled teleportation, in which a designated agent (i.e., the recoverer) can recover the teleported state with the help of the controllers. However, the controller may attempt to cheat the recoverer during the phase of recovering the secret state. How can we detect this cheating? In this paper, we considered the problem of detecting the controller's cheating in Quantum State Sharing, and further proposed an effective Quantum State Sharing scheme against the controller's cheating. We cleverly use Quantum Secret Sharing, Multiple Quantum States Sharing and decoy-particle techniques. In our scheme, via a previously shared entanglement state Alice can teleport multiple arbitrary multi-qubit states to Bob with the help of Charlie. Furthermore, by the classical information shared previously, Alice and Bob can check whether there is any cheating of Charlie. In addition, our scheme only needs to perform Bell-state and single-particle measurements, and to apply C-NOT gate and other single-particle unitary operations. With the present techniques, it is feasible to implement these necessary measurements and operations.

  15. Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitidis.

    PubMed

    Saleem, Muhammad; Prince, Stephen M; Rigby, Stephen E J; Imran, Muhammad; Patel, Hema; Chan, Hannah; Sanders, Holly; Maiden, Martin C J; Feavers, Ian M; Derrick, Jeremy P

    2013-01-01

    FrpB is an outer membrane transporter from Neisseria meningitidis, the causative agent of meningococcal meningitis. It is a member of the TonB-dependent transporter (TBDT) family and is responsible for iron uptake into the periplasm. FrpB is subject to a high degree of antigenic variation, principally through a region of hypervariable sequence exposed at the cell surface. From the crystal structures of two FrpB antigenic variants, we identify a bound ferric ion within the structure which induces structural changes on binding which are consistent with it being the transported substrate. Binding experiments, followed by elemental analysis, verified that FrpB binds Fe(3+) with high affinity. EPR spectra of the bound Fe(3+) ion confirmed that its chemical environment was consistent with that observed in the crystal structure. Fe(3+) binding was reduced or abolished on mutation of the Fe(3+)-chelating residues. FrpB orthologs were identified in other Gram-negative bacteria which showed absolute conservation of the coordinating residues, suggesting the existence of a specific TBDT sub-family dedicated to the transport of Fe(3+). The region of antigenic hypervariability lies in a separate, external sub-domain, whose structure is conserved in both the F3-3 and F5-1 variants, despite their sequence divergence. We conclude that the antigenic sub-domain has arisen separately as a result of immune selection pressure to distract the immune response from the primary transport function. This would enable FrpB to function as a transporter independently of antibody binding, by using the antigenic sub-domain as a 'molecular decoy' to distract immune surveillance.

  16. Elevated Serum Levels of the Antiapoptotic Protein Decoy-Receptor 3 Are Associated with Advanced Liver Disease.

    PubMed

    Bamias, Giorgos; Gizis, Michalis; Delladetsima, Ioanna; Laoudi, Eyfrosyni; Siakavellas, Spyros I; Koutsounas, Ioannis; Kaltsa, Garyfallia; Vlachogiannakos, John; Vafiadis-Zouboulis, Irene; Daikos, George L; Papatheodoridis, George V; Ladas, Spiros D

    2016-01-01

    Background. Decoy-receptor 3 (DcR3) exerts antiapoptotic and immunomodulatory function and is overexpressed in neoplastic and inflammatory conditions. Serum DcR3 (sDcR3) levels during the chronic hepatitis/cirrhosis/hepatocellular carcinoma (HCC) sequence have not been explored. Objective. To assess the levels and significance of sDcR3 protein in various stages of chronic liver disease. Methods. We compared sDcR3 levels between healthy controls and patients with chronic viral hepatitis (CVH), decompensated cirrhosis (DC), and HCC. Correlations between sDcR3 levels and various patient- and disease-related factors were analyzed. Results. sDcR3 levels were significantly higher in patients with CVH than in controls (P < 0.01). sDcR3 levels were elevated in DC and HCC, being significantly higher compared not only to controls (P < 0.001 for both) but to CVH patients as well (P < 0.001 for both). In addition, DcR3 protein was detected in large quantities in the ascitic fluid of cirrhotics. In patients with CVH, sDcR3 significantly correlated to fibrosis severity, as estimated by Ishak score (P = 0.019) or by liver stiffness measured with elastography (Spearman r = 0.698, P < 0.001). In cirrhotic patients, significant positive correlations were observed between sDcR3 levels and markers of severity of hepatic impairment, including MELD score (r = 0.653, P < 0.001). Conclusions. Circulating levels of DcR3 are elevated during chronic liver disease and correlate with severity of liver damage. sDcR3 may serve as marker for liver fibrosis severity and progression to end-stage liver disease. PMID:27595094

  17. β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.

    PubMed

    Watts, Anne O; Verkaar, Folkert; van der Lee, Miranda M C; Timmerman, Claudia A W; Kuijer, Martien; van Offenbeek, Jody; van Lith, Lambertus H C J; Smit, Martine J; Leurs, Rob; Zaman, Guido J R; Vischer, Henry F

    2013-03-01

    Chemokine receptors form a large subfamily of G protein-coupled receptors that predominantly activate heterotrimeric Gi proteins and are involved in immune cell migration. CCX-CKR is an atypical chemokine receptor with high affinity for CCL19, CCL21, and CCL25 chemokines, but is not known to activate intracellular signaling pathways. However, CCX-CKR acts as decoy receptor and efficiently internalizes these chemokines, thereby preventing their interaction with other chemokine receptors, like CCR7 and CCR9. Internalization of fluorescently labeled CCL19 correlated with β-arrestin2-GFP translocation. Moreover, recruitment of β-arrestins to CCX-CKR in response to CCL19, CCL21, and CCL25 was demonstrated using enzyme-fragment complementation and bioluminescence resonance energy transfer methods. To unravel why CCX-CKR is unable to activate Gi signaling, CCX-CKR chimeras were constructed by substituting its intracellular loops with the corresponding CCR7 or CCR9 domains. The signaling properties of chimeric CCX-CKR receptors were characterized using a cAMP-responsive element (CRE)-driven reporter gene assay. Unexpectedly, wild type CCX-CKR and a subset of the chimeras induced an increase in CRE activity in response to CCL19, CCL21, and CCL25 in the presence of the Gi inhibitor pertussis toxin. CCX-CKR signaling to CRE required an intact DRY motif. These data suggest that inactive Gi proteins impair CCX-CKR signaling most likely by hindering the interaction of this receptor with pertussis toxin-insensitive G proteins that transduce signaling to CRE. On the other hand, recruitment of the putative signaling scaffold β-arrestin to CCX-CKR in response to chemokines might allow activation of yet to be identified signal transduction pathways.

  18. ZP2 peptide beads select human sperm in vitro, decoy mouse sperm in vivo, and provide reversible contraception.

    PubMed

    Avella, Matteo A; Baibakov, Boris A; Jimenez-Movilla, Maria; Sadusky, Anna Burkart; Dean, Jurrien

    2016-04-27

    Gamete recognition in the female reproductive tract occurs at the surface of the zona pellucida surrounding ovulated eggs. The acellular zona matrix is composed of three (mouse) or four (human) proteins (ZP1 to ZP4), and the amino terminus of ZP2 is the primary sperm-binding ligand. Mouse and human sperm bind, respectively, to recombinant moZP2(35-149) and huZP2(39-154) peptides attached to agarose beads. Mouse ZP2 peptide beads markedly inhibited fertilization of ovulated mouse eggs inseminated in vitro and incubated overnight. Similarly, human ZP2 peptide beads prevented sperm binding and penetration of transgenic ZP2(Rescue) zonae pellucidae, in which human ZP2 replaced mouse ZP2. When mouse ZP2 peptide beads were transcervically deposited into the uterus, there was no change in mating behavior and copulatory plugs were present, but bound sperm did not progress into the oviduct and female mice were infertile. On average, contraception lasted >10 estrus cycles but was reversible with no detectable pathology in the reproductive tract. Despite the long-term contraceptive effect, initial sperm binding to the peptide beads was reversible in vitro. We exploited this observation to select human sperm that were better able to penetrate the zonae of human ZP2(Rescue) eggs, and the approach holds promise for identifying superior sperm for human assisted reproductive technologies (ART). We conclude that the amino-terminal ZP2 peptide supports sperm binding, which is initially reversible but, with time, becomes irreversible. Short-term, reversible binding may be useful in selecting sperm for ART, and long-term binding decoys sperm and results in effective contraception in mice.

  19. Elevated Serum Levels of the Antiapoptotic Protein Decoy-Receptor 3 Are Associated with Advanced Liver Disease

    PubMed Central

    Gizis, Michalis; Delladetsima, Ioanna; Laoudi, Eyfrosyni; Siakavellas, Spyros I.; Kaltsa, Garyfallia; Vlachogiannakos, John; Vafiadis-Zouboulis, Irene; Daikos, George L.; Papatheodoridis, George V.

    2016-01-01

    Background. Decoy-receptor 3 (DcR3) exerts antiapoptotic and immunomodulatory function and is overexpressed in neoplastic and inflammatory conditions. Serum DcR3 (sDcR3) levels during the chronic hepatitis/cirrhosis/hepatocellular carcinoma (HCC) sequence have not been explored. Objective. To assess the levels and significance of sDcR3 protein in various stages of chronic liver disease. Methods. We compared sDcR3 levels between healthy controls and patients with chronic viral hepatitis (CVH), decompensated cirrhosis (DC), and HCC. Correlations between sDcR3 levels and various patient- and disease-related factors were analyzed. Results. sDcR3 levels were significantly higher in patients with CVH than in controls (P < 0.01). sDcR3 levels were elevated in DC and HCC, being significantly higher compared not only to controls (P < 0.001 for both) but to CVH patients as well (P < 0.001 for both). In addition, DcR3 protein was detected in large quantities in the ascitic fluid of cirrhotics. In patients with CVH, sDcR3 significantly correlated to fibrosis severity, as estimated by Ishak score (P = 0.019) or by liver stiffness measured with elastography (Spearman r = 0.698, P < 0.001). In cirrhotic patients, significant positive correlations were observed between sDcR3 levels and markers of severity of hepatic impairment, including MELD score (r = 0.653, P < 0.001). Conclusions. Circulating levels of DcR3 are elevated during chronic liver disease and correlate with severity of liver damage. sDcR3 may serve as marker for liver fibrosis severity and progression to end-stage liver disease. PMID:27595094

  20. Optical quantum computing.

    PubMed

    O'Brien, Jeremy L

    2007-12-01

    In 2001, all-optical quantum computing became feasible with the discovery that scalable quantum computing is possible using only single-photon sources, linear optical elements, and single-photon detectors. Although it was in principle scalable, the massive resource overhead made the scheme practically daunting. However, several simplifications were followed by proof-of-principle demonstrations, and recent approaches based on cluster states or error encoding have dramatically reduced this worrying resource overhead, making an all-optical architecture a serious contender for the ultimate goal of a large-scale quantum computer. Key challenges will be the realization of high-efficiency sources of indistinguishable single photons, low-loss, scalable optical circuits, high-efficiency single-photon detectors, and low-loss interfacing of these components.

  1. A Quantum-Based Similarity Method in Virtual Screening.

    PubMed

    Al-Dabbagh, Mohammed Mumtaz; Salim, Naomie; Himmat, Mubarak; Ahmed, Ali; Saeed, Faisal

    2015-10-02

    One of the most widely-used techniques for ligand-based virtual screening is similarity searching. This study adopted the concepts of quantum mechanics to present as state-of-the-art similarity method of molecules inspired from quantum theory. The representation of molecular compounds in mathematical quantum space plays a vital role in the development of quantum-based similarity approach. One of the key concepts of quantum theory is the use of complex numbers. Hence, this study proposed three various techniques to embed and to re-represent the molecular compounds to correspond with complex numbers format. The quantum-based similarity method that developed in this study depending on complex pure Hilbert space of molecules called Standard Quantum-Based (SQB). The recall of retrieved active molecules were at top 1% and top 5%, and significant test is used to evaluate our proposed methods. The MDL drug data report (MDDR), maximum unbiased validation (MUV) and Directory of Useful Decoys (DUD) data sets were used for experiments and were represented by 2D fingerprints. Simulated virtual screening experiment show that the effectiveness of SQB method was significantly increased due to the role of representational power of molecular compounds in complex numbers forms compared to Tanimoto benchmark similarity measure.

  2. SU-E-I-62: Assessing Radiation Dose Reduction and CT Image Optimization Through the Measurement and Analysis of the Detector Quantum Efficiency (DQE) of CT Images Using Different Beam Hardening Filters

    SciTech Connect

    Collier, J; Aldoohan, S; Gill, K

    2014-06-01

    Purpose: Reducing patient dose while maintaining (or even improving) image quality is one of the foremost goals in CT imaging. To this end, we consider the feasibility of optimizing CT scan protocols in conjunction with the application of different beam-hardening filtrations and assess this augmentation through noise-power spectrum (NPS) and detector quantum efficiency (DQE) analysis. Methods: American College of Radiology (ACR) and Catphan phantoms (The Phantom Laboratory) were scanned with a 64 slice CT scanner when additional filtration of thickness and composition (e.g., copper, nickel, tantalum, titanium, and tungsten) had been applied. A MATLAB-based code was employed to calculate the image of noise NPS. The Catphan Image Owl software suite was then used to compute the modulated transfer function (MTF) responses of the scanner. The DQE for each additional filter, including the inherent filtration, was then computed from these values. Finally, CT dose index (CTDIvol) values were obtained for each applied filtration through the use of a 100 mm pencil ionization chamber and CT dose phantom. Results: NPS, MTF, and DQE values were computed for each applied filtration and compared to the reference case of inherent beam-hardening filtration only. Results showed that the NPS values were reduced between 5 and 12% compared to inherent filtration case. Additionally, CTDIvol values were reduced between 15 and 27% depending on the composition of filtration applied. However, no noticeable changes in image contrast-to-noise ratios were noted. Conclusion: The reduction in the quanta noise section of the NPS profile found in this phantom-based study is encouraging. The reduction in both noise and dose through the application of beam-hardening filters is reflected in our phantom image quality. However, further investigation is needed to ascertain the applicability of this approach to reducing patient dose while maintaining diagnostically acceptable image qualities in a

  3. Neutron detector

    DOEpatents

    Stephan, Andrew C.; Jardret; Vincent D.

    2011-04-05

    A neutron detector has a volume of neutron moderating material and a plurality of individual neutron sensing elements dispersed at selected locations throughout the moderator, and particularly arranged so that some of the detecting elements are closer to the surface of the moderator assembly and others are more deeply embedded. The arrangement captures some thermalized neutrons that might otherwise be scattered away from a single, centrally located detector element. Different geometrical arrangements may be used while preserving its fundamental characteristics. Different types of neutron sensing elements may be used, which may operate on any of a number of physical principles to perform the function of sensing a neutron, either by a capture or a scattering reaction, and converting that reaction to a detectable signal. High detection efficiency, an ability to acquire spectral information, and directional sensitivity may be obtained.

  4. Neutron detector

    SciTech Connect

    Stephan, Andrew C; Jardret, Vincent D

    2009-04-07

    A neutron detector has a volume of neutron moderating material and a plurality of individual neutron sensing elements dispersed at selected locations throughout the moderator, and particularly arranged so that some of the detecting elements are closer to the surface of the moderator assembly and others are more deeply embedded. The arrangement captures some thermalized neutrons that might otherwise be scattered away from a single, centrally located detector element. Different geometrical arrangements may be used while preserving its fundamental characteristics. Different types of neutron sensing elements may be used, which may operate on any of a number of physical principles to perform the function of sensing a neutron, either by a capture or a scattering reaction, and converting that reaction to a detectable signal. High detection efficiency, an ability to acquire spectral information, and directional sensitivity may be obtained.

  5. Angle detector

    NASA Technical Reports Server (NTRS)

    Parra, G. T. (Inventor)

    1978-01-01

    An angle detector for determining a transducer's angular disposition to a capacitive pickup element is described. The transducer comprises a pendulum mounted inductive element moving past the capacitive pickup element. The capacitive pickup element divides the inductive element into two parts L sub 1 and L sub 2 which form the arms of one side of an a-c bridge. Two networks R sub 1 and R sub 2 having a plurality of binary weighted resistors and an equal number of digitally controlled switches for removing resistors from the networks form the arms of the other side of the a-c bridge. A binary counter, controlled by a phase detector, balances the bridge by adjusting the resistance of R sub 1 and R sub 2. The binary output of the counter is representative of the angle.

  6. Flame Detector

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Scientific Instruments, Inc. has now developed a second generation, commercially available instrument to detect flames in hazardous environments, typically refineries, chemical plants and offshore drilling platforms. The Model 74000 detector incorporates a sensing circuit that detects UV radiation in a 100 degree conical field of view extending as far as 250 feet from the instrument. It operates in a bandwidth that makes it virtually 'blind' to solar radiation while affording extremely high sensitivity to ultraviolet flame detection. A 'windowing' technique accurately discriminates between background UV radiation and ultraviolet emitted from an actual flame, hence the user is assured of no false alarms. Model 7410CP is a combination controller and annunciator panel designed to monitor and control as many as 24 flame detectors. *Model 74000 is no longer being manufactured.

  7. An arbitrated quantum signature scheme with fast signing and verifying

    NASA Astrophysics Data System (ADS)

    Liu, Feng; Qin, Su-Juan; Su, Qi

    2013-11-01

    Existing arbitrated quantum signature (AQS) schemes are almost all based on the Leung quantum one-time pad (L-QOTP) algorithm. In these schemes, the receiver can achieve an existential forgery of the sender's signatures under the known message attack, and the sender can successfully disavow any of her/his signatures by a simple attack. In this paper, a solution of solving the problems is given, through designing a new QOTP algorithm relying largely on inserting decoy states into fixed insertion positions. Furthermore, we present an AQS scheme with fast signing and verifying, which is based on the new QOTP algorithm. It is just using single particle states and is unconditional secure. To fulfill the functions of AQS schemes, our scheme needs a significantly lower computational costs than that required by other AQS schemes based on the L-QOTP algorithm.

  8. Neutrino Detectors

    NASA Astrophysics Data System (ADS)

    von Feilitzsch, Franz; Lanfranchi, Jean-Côme; Wurm, Michael

    The neutrino was postulated by Wolfgang Pauli in the early 1930s, but could only be detected for the first time in the 1950s. Ever since scientists all around the world have worked on the detection and understanding of this particle which so scarcely interacts with matter. Depending on the origin and nature of the neutrino, various types of experiments have been developed and operated. In this entry, we will review neutrino detectors in terms of neutrino energy and associated detection technique as well as the scientific outcome of some selected examples. After a brief historical introduction, the detection of low-energy neutrinos originating from nuclear reactors or from the Earth is used to illustrate the principles and difficulties which are encountered in detecting neutrinos. In the context of solar neutrino spectroscopy, where the neutrino is used as a probe for astrophysics, three different types of neutrino detectors are presented - water Čerenkov, radiochemical, and liquid-scintillator detectors. Moving to higher neutrino energies, we discuss neutrinos produced by astrophysical sources and from accelerators. The entry concludes with an overview of a selection of future neutrino experiments and their scientific goals.

  9. Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to its soluble decoy receptor IL-22BP.

    PubMed

    Watanabe, Leandra; de Moura, Patricia Ribeiro; Nascimento, Alessandro Silva; Colau, Didier; Dumoutier, Laure; Renauld, Jean Christophe; Polikarpov, Igor

    2009-02-01

    Interleukin-22 (IL-22) is a pleiotropic cytokine that is involved in inflammatory responses. Human IL-22 was incubated with its soluble decoy receptor IL-22BP (IL-22 binding protein) and the IL-22-IL-22BP complex was crystallized in hanging drops using the vapour-diffusion method. Suitable crystals were obtained from polyethylene glycol solutions and diffraction data were collected to 2.75 A resolution. The crystal belonged to the tetragonal space group P4(1), with unit-cell parameters a = b = 67.9, c = 172.5 A, and contained two IL-22-IL-22BP complexes per asymmetric unit.

  10. Deterministic Secure Quantum Communication and Authentication Protocol based on Extended GHZ-W State and Quantum One-time Pad

    NASA Astrophysics Data System (ADS)

    Li, Na; Li, Jian; Li, Lei-Lei; Wang, Zheng; Wang, Tao

    2016-08-01

    A deterministic secure quantum communication and authentication protocol based on extended GHZ-W state and quantum one-time pad is proposed. In the protocol, state | φ -> is used as the carrier. One photon of | φ -> state is sent to Alice, and Alice obtains a random key by measuring photons with bases determined by ID. The information of bases is secret to others except Alice and Bob. Extended GHZ-W states are used as decoy photons, the positions of which in information sequence are encoded with identity string ID of the legal user, and the eavesdropping detection rate reaches 81%. The eavesdropping detection based on extended GHZ-W state combines with authentication and the secret ID ensures the security of the protocol.

  11. MCP detector development for WSO-UV

    NASA Astrophysics Data System (ADS)

    Diebold, Sebastian; Barnstedt, Jürgen; Elsener, Hans-Rudolf; Ganz, Philipp; Hermanutz, Stephan; Kalkuhl, Christoph; Kappelmann, Norbert; Pfeifer, Marc; Schaadt, Daniel; Schanz, Thomas; Tanirah, Omar; Werner, Klaus

    2012-09-01

    The spectrographs of WSO-UV cover the wavelength range of 102 - 310 nm. The essential requirements for the associated detectors are high quantum effciency, solar blindness, and single photon detection. To achieve this, we develop a microchannel plate detector in a sealed tube. We plan to use cesium activated gallium nitride as semitransparent photocathode, a stack of two microchannel plates and a cross strip anode with advanced readout electronics. Challenges are the degradation of the photocathode under atmospheric conditions and the sealing process. We present the detector concept, details of the transfer and sealing processes under UHV, and the current status.

  12. Ghost imaging with a single detector

    SciTech Connect

    Bromberg, Yaron; Katz, Ori; Silberberg, Yaron

    2009-05-15

    We experimentally demonstrate pseudothermal ghost imaging and ghost diffraction using only a single detector. We achieve this by replacing the high-resolution detector of the reference beam with a computation of the propagating field, following a recent proposal by Shapiro [Phys. Rev. A 78, 061802(R) (2008)]. Since only a single detector is used, this provides experimental evidence that pseudothermal ghost imaging does not rely on nonlocal quantum correlations. In addition, we show the depth-resolving capability of this ghost imaging technique.

  13. Low light level detectors for astronomy.

    PubMed

    Boyce, P B

    1977-10-14

    There is an almost bewildering variety of detectors being used for ground-based astronomical observations. Many of the detectors have advantages for particular projects. One-dimensional detectors are simple, yet suitable for spectroscopy. Other detectors offer high photometric precision and dimensional stability. Some are designed for observing only faint objects and some for bright ones. Sometimes the necessity of having a high quantum efficiency at a particular wavelength dictates the choice of detector. In reality the situation is even more chaotic. This review has not covered some of the exotic detectors that have been developed for x-ray and far-ultraviolet imaging from spacecraft. These detectors use devices such as resistive plates, multianode or crossed-wire microchannel plates, and so on. These devices have not yet seen extensive use in ground-based applications, and their future as visible light detectors remains uncertain. The reasons for the development of such a wide variety of detectors are clear. Commercially available devices are simply not capable of meeting the low light level and photometric performance capabilities needed for astronomical observations. The driving forces are the commercial and military applications for detectors, and with few exceptions there has not been sufficient funding available to mount a detector development program for astronomy. Therefore, astronomers have sought to adapt existing commercial devices to the particular problem at hand. The large number of individual efforts summarized in this review is the result. In the future, I expect the variety to diminish as one or two really good detectors become capable of performing well under the wide variety of observational conditions encountered in astronomy. Many people have proclaimed the ultimate detector to be just around the corner. This is yet to happen. However, I venture to speculate that low-noise, high-performance CCD detectors with a format of 500 by 500 or larger

  14. Multiparty quantum sealed-bid auction using single photons as message carrier

    NASA Astrophysics Data System (ADS)

    Liu, Wen-Jie; Wang, Hai-Bin; Yuan, Gong-Lin; Xu, Yong; Chen, Zhen-Yu; An, Xing-Xing; Ji, Fu-Gao; Gnitou, Gnim Tchalim

    2016-02-01

    In this study, a novel multiparty quantum sealed-bid auction protocol using the single photons as the message carrier of bids is proposed, followed by an example of three-party auction. Compared with those protocols based on the entangled states (GHZ state, EPR pairs, etc.), the present protocol is more economic and feasible within present technology. In order to guarantee the security and the fairness of the auction, the decoy photon checking technique and an improved post-confirmation mechanism with EPR pairs are introduced, respectively.

  15. Quantum states prepared by realistic entanglement swapping

    SciTech Connect

    Scherer, Artur; Howard, Regina B.; Sanders, Barry C.; Tittel, Wolfgang

    2009-12-15

    Entanglement swapping between photon pairs is a fundamental building block in schemes using quantum relays or quantum repeaters to overcome the range limits of long-distance quantum key distribution. We develop a closed-form solution for the actual quantum states prepared by realistic entanglement swapping, which takes into account experimental deficiencies due to inefficient detectors, detector dark counts, and multiphoton-pair contributions of parametric down-conversion sources. We investigate how the entanglement present in the final state of the remaining modes is affected by the real-world imperfections. To test the predictions of our theory, comparison with previously published experimental entanglement swapping is provided.

  16. Electron gas grid semiconductor radiation detectors

    DOEpatents

    Lee, Edwin Y.; James, Ralph B.

    2002-01-01

    An electron gas grid semiconductor radiation detector (EGGSRAD) useful for gamma-ray and x-ray spectrometers and imaging systems is described. The radiation detector employs doping of the semiconductor and variation of the semiconductor detector material to form a two-dimensional electron gas, and to allow transistor action within the detector. This radiation detector provides superior energy resolution and radiation detection sensitivity over the conventional semiconductor radiation detector and the "electron-only" semiconductor radiation detectors which utilize a grid electrode near the anode. In a first embodiment, the EGGSRAD incorporates delta-doped layers adjacent the anode which produce an internal free electron grid well to which an external grid electrode can be attached. In a second embodiment, a quantum well is formed between two of the delta-doped layers, and the quantum well forms the internal free electron gas grid to which an external grid electrode can be attached. Two other embodiments which are similar to the first and second embodiment involve a graded bandgap formed by changing the composition of the semiconductor material near the first and last of the delta-doped layers to increase or decrease the conduction band energy adjacent to the delta-doped layers.

  17. Dust Detector

    NASA Technical Reports Server (NTRS)

    Kelley, M. C.

    2001-01-01

    We discuss a recent sounding rocket experiment which found charged dust in the Earth's tropical mesosphere. The dust detector was designed to measure small (5000 - 10000 amu.) charged dust particles, most likely of meteoric origin. A 5 km thick layer of positively charged dust was found at an altitude of 90 km, in the vicinity of an observed sporadic sodium layer and sporadic E layer. The observed dust was positively charged in the bulk of the dust layer, but was negatively charged near the bottom.

  18. Ion detector

    DOEpatents

    Tullis, Andrew M.

    1987-01-01

    An improved ion detector device of the ionization detection device chamber ype comprises an ionization chamber having a central electrode therein surrounded by a cylindrical electrode member within the chamber with a collar frictionally fitted around at least one of the electrodes. The collar has electrical contact means carried in an annular groove in an inner bore of the collar to contact the outer surface of the electrode to provide electrical contact between an external terminal and the electrode without the need to solder leads to the electrode.

  19. Quantum computing

    PubMed Central

    Li, Shu-Shen; Long, Gui-Lu; Bai, Feng-Shan; Feng, Song-Lin; Zheng, Hou-Zhi

    2001-01-01

    Quantum computing is a quickly growing research field. This article introduces the basic concepts of quantum computing, recent developments in quantum searching, and decoherence in a possible quantum dot realization. PMID:11562459

  20. The theory research of multi-user quantum access network with Measurement Device Independent quantum key distribution

    NASA Astrophysics Data System (ADS)

    Ji, Yi-Ming; Li, Yun-Xia; Shi, Lei; Meng, Wen; Cui, Shu-Min; Xu, Zhen-Yu

    2015-10-01

    Quantum access network can't guarantee the absolute security of multi-user detector and eavesdropper can get access to key information through time-shift attack and other ways. Measurement-device-independent quantum key distribution is immune from all the detection attacks, and accomplishes the safe sharing of quantum key. In this paper, that Measurement-device-independent quantum key distribution is used in the application of multi-user quantum access to the network is on the research. By adopting time-division multiplexing technology to achieve the sharing of multiuser detector, the system structure is simplified and the security of quantum key sharing is acquired.

  1. Decoy receptor 3 suppresses FasL-induced apoptosis via ERK1/2 activation in pancreatic cancer cells

    SciTech Connect

    Zhang, Yi; Li, Dechun; Zhao, Xin; Song, Shiduo; Zhang, Lifeng; Zhu, Dongming; Wang, Zhenxin; Chen, Xiaochen; Zhou, Jian

    2015-08-07

    Resistance to Fas Ligand (FasL) mediated apoptosis plays an important role in tumorigenesis. Decoy receptor 3 (DcR3) is reported to interact with FasL and is overexpressed in some malignant tumors. We sought to investigate the role of DcR3 in resistance to FasL in pancreatic cancer. We compared expression of apoptosis related genes between FasL-resistant SW1990 and FasL-sensitive Patu8988 pancreatic cell lines by microarray analysis. We explored the impact of siRNA knockdown of, or exogenous supplementation with, DcR3 on FasL-induced cell growth inhibition in pancreatic cancer cell lines and expression of proteins involved in apoptotic signaling. We assessed the level of DcR3 protein and ERK1/2 phosphorylation in tumor and non-tumor tissue samples of 66 patients with pancreatic carcinoma. RNAi knockdown of DcR3 expression in SW1990 cells reduced resistance to FasL-induced apoptosis, and supplementation of Patu8988 with rDcR3 had the opposite effect. RNAi knockdown of DcR3 in SW1990 cells elevated expression of caspase 3, 8 and 9, and reduced ERK1/2 phosphorylation (P < 0.05), but did not alter phosphorylated-Akt expression. 47 tumor tissue specimens, but only 15 matched non-tumor specimens stained for DcR3 (χ{sup 2} = 31.1447, P < 0.001). The proliferation index of DcR3 positive specimens (14.26  ±  2.67%) was significantly higher than that of DcR3 negative specimens (43.58  ±  7.88%, P < 0.01). DcR3 expression positively correlated with p-ERK1/2 expression in pancreatic cancer tissues (r = 0.607, P < 0.001). DcR3 enhances ERK1/2 phosphorylation and opposes FasL signaling in pancreatic cancer cells. - Highlights: • We investigated the role of DcR3 in FasL resistance in pancreatic cancer. • Knockdown of DcR3 in SW1990 cells reduced resistance to FasL-induced apoptosis. • DcR3 knockdown also elevated caspase expression, and reduced ERK1/2 phosphorylation. • Tumor and non-tumor tissues were collected from 66 pancreatic carcinoma patients

  2. Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia

    PubMed Central

    Zhang, Qifang; Hossain, Dewan Md Sakib; Duttagupta, Priyanka; Moreira, Dayson; Zhao, Xingli; Won, Haejung; Buettner, Ralf; Nechaev, Sergey; Majka, Marcin; Zhang, Bin; Cai, Qi; Swiderski, Piotr; Kuo, Ya-Huei; Forman, Stephen; Marcucci, Guido

    2016-01-01

    Targeting oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) in acute myeloid leukemia (AML) can reduce blast survival and tumor immune evasion. Decoy oligodeoxynucleotides (dODNs), which comprise STAT3-specific DNA sequences are competitive inhibition of STAT3 transcriptional activity. To deliver STAT3dODN specifically to myeloid cells, we linked STAT3dODN to the Toll-like receptor 9 (TLR9) ligand, cytosine guanine dinucleotide (CpG). The CpG-STAT3dODN conjugates are quickly internalized by human and mouse TLR9+ immune cells (dendritic cells, B cells) and the majority of patients’ derived AML blasts, including leukemia stem/progenitor cells. Following uptake, CpG-STAT3dODNs are released from endosomes, and bind and sequester cytoplasmic STAT3, thereby inhibiting downstream gene expression in target cells. STAT3 inhibition in patients’ AML cells limits their immunosuppressive potential by reduced arginase expression, thereby partly restoring T-cell proliferation. Partly chemically modified CpG-STAT3dODNs have >60 hours serum half-life which allows for IV administration to leukemia-bearing mice (50% effective dose ∼ 2.5 mg/kg). Repeated administration of CpG-STAT3dODN resulted in regression of human MV4-11 AML in mice. The antitumor efficacy of this strategy is further enhanced in immunocompetent mice by combining direct leukemia-specific cytotoxicity with immunogenic effects of STAT3 blocking/TLR9 triggering. CpG-STAT3dODN effectively reduced Cbfb/MYH11/Mpl AML burden in various organs and eliminated leukemia stem/progenitor cells, mainly through CD8/CD4 T-cell–mediated immune responses. In contrast, small-molecule Janus kinase 2/STAT3 inhibitor failed to reproduce therapeutic effects of cell-selective CpG-STAT3dODN strategy. These results demonstrate therapeutic potential of CpG-STAT3dODN inhibitors with broad implications for treatement of AML and potentially other hematologic malignancies. PMID:26796361

  3. Selection of Single-Stranded DNA Molecular Recognition Elements against Exotoxin A Using a Novel Decoy-SELEX Method and Sensitive Detection of Exotoxin A in Human Serum

    PubMed Central

    Hong, Ka Lok; Yancey, Kailey; Battistella, Luisa; Williams, Ryan M.; Hickey, Katherine M.; Bostick, Chris D.; Gannett, Peter M.; Sooter, Letha J.

    2015-01-01

    Exotoxin A is one of the virulence factors of Pseudomonas aeruginosa, a bacterium that can cause infections resulting in adverse health outcomes and increased burden to health care systems. Current methods of diagnosing P. aeruginosa infections are time consuming and can require significant preparation of patient samples. This study utilized a novel variation of the Systematic Evolution of Ligand by Exponential Enrichment, Decoy-SELEX, to identify an Exotoxin A specific single-stranded DNA (ssDNA) molecular recognition element (MRE). Its emphasis is on increasing stringency in directing binding toward free target of interest and at the same time decreasing binding toward negative targets. A ssDNA MRE with specificity and affinity was identified after fourteen rounds of Decoy-SELEX. Utilizing surface plasmon resonance measurements, the determined equilibrium dissociation constant (Kd) of the MRE is between 4.2 µM and 4.5 µM, and is highly selective for Exotoxin A over negative targets. A ssDNA MRE modified sandwich enzyme-linked immunosorbent assay (ELISA) has been developed and achieved sensitive detection of Exotoxin A at nanomolar concentrations in human serum. This study has demonstrated the proof-of-principle of using a ssDNA MRE as a clinical diagnostic tool. PMID:26636098

  4. Measurement-device-independent quantum key distribution.

    PubMed

    Lo, Hoi-Kwong; Curty, Marcos; Qi, Bing

    2012-03-30

    How to remove detector side channel attacks has been a notoriously hard problem in quantum cryptography. Here, we propose a simple solution to this problem--measurement-device-independent quantum key distribution (QKD). It not only removes all detector side channels, but also doubles the secure distance with conventional lasers. Our proposal can be implemented with standard optical components with low detection efficiency and highly lossy channels. In contrast to the previous solution of full device independent QKD, the realization of our idea does not require detectors of near unity detection efficiency in combination with a qubit amplifier (based on teleportation) or a quantum nondemolition measurement of the number of photons in a pulse. Furthermore, its key generation rate is many orders of magnitude higher than that based on full device independent QKD. The results show that long-distance quantum cryptography over say 200 km will remain secure even with seriously flawed detectors.

  5. Measurement-device-independent quantum key distribution.

    PubMed

    Lo, Hoi-Kwong; Curty, Marcos; Qi, Bing

    2012-03-30

    How to remove detector side channel attacks has been a notoriously hard problem in quantum cryptography. Here, we propose a simple solution to this problem--measurement-device-independent quantum key distribution (QKD). It not only removes all detector side channels, but also doubles the secure distance with conventional lasers. Our proposal can be implemented with standard optical components with low detection efficiency and highly lossy channels. In contrast to the previous solution of full device independent QKD, the realization of our idea does not require detectors of near unity detection efficiency in combination with a qubit amplifier (based on teleportation) or a quantum nondemolition measurement of the number of photons in a pulse. Furthermore, its key generation rate is many orders of magnitude higher than that based on full device independent QKD. The results show that long-distance quantum cryptography over say 200 km will remain secure even with seriously flawed detectors. PMID:22540686

  6. Practical quantum repeaters with parametric down-conversion sources

    NASA Astrophysics Data System (ADS)

    Krovi, Hari; Guha, Saikat; Dutton, Zachary; Slater, Joshua A.; Simon, Christoph; Tittel, Wolfgang

    2016-03-01

    Conventional wisdom suggests that realistic quantum repeaters will require quasi-deterministic sources of entangled photon pairs. In contrast, we here study a quantum repeater architecture that uses simple parametric down-conversion sources, as well as frequency-multiplexed multimode quantum memories and photon-number-resolving detectors. We show that this approach can significantly extend quantum communication distances compared to direct transmission. This shows that important trade-offs are possible between the different components of quantum repeater architectures.

  7. Quantum Mechanics

    NASA Astrophysics Data System (ADS)

    Auletta, Gennaro; Fortunato, Mauro; Parisi, Giorgio

    2014-01-01

    Introduction; Part I. Basic Features of Quantum Mechanics: 1. From classical mechanics to quantum mechanics; 2. Quantum observable and states; 3. Quantum dynamics; 4. Examples of quantum dynamics; 5. Density matrix; Part II. More Advanced Topics: 6. Angular momentum and spin; 7. Identical particles; 8. Symmetries and conservation laws; 9. The measurement problem; Part III. Matter and Light: 10. Perturbations and approximation methods; 11. Hydrogen and helium atoms; 12. Hydrogen molecular ion; 13. Quantum optics; Part IV. Quantum Information: State and Correlations: 14. Quantum theory of open systems; 15. State measurement in quantum mechanics; 16. Entanglement: non-separability; 17. Entanglement: quantum information; References; Index.

  8. Oscillator detector

    SciTech Connect

    Potter, B.M.

    1980-05-13

    An alien liquid detector employs a monitoring element and an oscillatory electronic circuit for maintaining the temperature of the monitoring element substantially above ambient temperature. The output wave form, eg., frequency of oscillation or wave shape, of the oscillatory circuit depends upon the temperaturedependent electrical characteristic of the monitoring element. A predetermined change in the output waveform allows water to be discriminated from another liquid, eg., oil. Features of the invention employing two thermistors in two oscillatory circuits include positioning one thermistor for contact with water and the other thermistor above the oil-water interface to detect a layer of oil if present. Unique oscillatory circuit arrangements are shown that achieve effective thermistor action with an economy of parts and energizing power. These include an operational amplifier employed in an astable multivibrator circuit, a discrete transistor-powered tank circuit, and use of an integrated circuit chip.

  9. Cs based photocathodes for gaseous detectors

    SciTech Connect

    Borovick-Romanov, A.; Peskov, V.

    1993-08-01

    We demonstrated that some standard photocathodes SbCs, GaAs(Cs), Au(Cs) can easily be manufactured for use inside gaseous detectors. When filed with clean quenched gases such detectors have a quantum efficiency of a few percent in the visible region of the spectra and can operate at a gain >10{sup 3}. We tried to make these photocathodes more air stable by protecting their surfaces with a thin layer of CsI or liquid TMAE. The most air stable were photocathodes with a CsI protective layer. A wavelengths {le}185 nm such photocathodes have the highest quantum efficiency among all known air stable photocathodes, including CsI. Gaseous detectors with such photocathodes can operate at a gain of 10{sup 5}. Results of first tests of doped CsI photocathode are also presented. Possible fields of application of new photocathodes are discussed.

  10. Long-distance measurement-device-independent quantum key distribution with coherent-state superpositions.

    PubMed

    Yin, H-L; Cao, W-F; Fu, Y; Tang, Y-L; Liu, Y; Chen, T-Y; Chen, Z-B

    2014-09-15

    Measurement-device-independent quantum key distribution (MDI-QKD) with decoy-state method is believed to be securely applied to defeat various hacking attacks in practical quantum key distribution systems. Recently, the coherent-state superpositions (CSS) have emerged as an alternative to single-photon qubits for quantum information processing and metrology. Here, in this Letter, CSS are exploited as the source in MDI-QKD. We present an analytical method that gives two tight formulas to estimate the lower bound of yield and the upper bound of bit error rate. We exploit the standard statistical analysis and Chernoff bound to perform the parameter estimation. Chernoff bound can provide good bounds in the long-distance MDI-QKD. Our results show that with CSS, both the security transmission distance and secure key rate are significantly improved compared with those of the weak coherent states in the finite-data case. PMID:26466295

  11. The Decoy Duck.

    ERIC Educational Resources Information Center

    Ryan, Anna

    1997-01-01

    Describes the development processes of an instructional video for use in a course offered through the Extended Learning Institute of Northern Virginia Community College entitled Women Writers II. Characterizes the process of transforming this English course from a print-based to a distance-learning course as time-consuming, creative, and…

  12. A Weak Value Based QKD Protocol Robust Against Detector Attacks

    NASA Astrophysics Data System (ADS)

    Troupe, James

    2015-03-01

    We propose a variation of the BB84 quantum key distribution protocol that utilizes the properties of weak values to insure the validity of the quantum bit error rate estimates used to detect an eavesdropper. The protocol is shown theoretically to be secure against recently demonstrated attacks utilizing detector blinding and control and should also be robust against all detector based hacking. Importantly, the new protocol promises to achieve this additional security without negatively impacting the secure key generation rate as compared to that originally promised by the standard BB84 scheme. Implementation of the weak measurements needed by the protocol should be very feasible using standard quantum optical techniques.

  13. The DUV Stability of Superlattice-Doped CMOS Detector Arrays

    NASA Technical Reports Server (NTRS)

    Hoenk, M. E.; Carver, A. G.; Jones, T.; Dickie, M.; Cheng, P.; Greer, H. F.; Nikzad, S.; Sgro, J.; Tsur, S.

    2013-01-01

    JPL and Alacron have recently developed a high performance, DUV camera with a superlattice doped CMOS imaging detector. Supperlattice doped detectors achieve nearly 100% internal quantum efficiency in the deep and far ultraviolet, and a single layer, Al2O3 antireflection coating enables 64% external quantum efficiency at 263nm. In lifetime tests performed at Applied Materials using 263 nm pulsed, solid state and 193 nm pulsed excimer laser, the quantum efficiency and dark current of the JPL/Alacron camera remained stable to better than 1% precision during long-term exposure to several billion laser pulses, with no measurable degradation, no blooming and no image memory at 1000 fps.

  14. Direct detector for terahertz radiation

    DOEpatents

    Wanke, Michael C.; Lee, Mark; Shaner, Eric A.; Allen, S. James

    2008-09-02

    A direct detector for terahertz radiation comprises a grating-gated field-effect transistor with one or more quantum wells that provide a two-dimensional electron gas in the channel region. The grating gate can be a split-grating gate having at least one finger that can be individually biased. Biasing an individual finger of the split-grating gate to near pinch-off greatly increases the detector's resonant response magnitude over prior QW FET detectors while maintaining frequency selectivity. The split-grating-gated QW FET shows a tunable resonant plasmon response to FIR radiation that makes possible an electrically sweepable spectrometer-on-a-chip with no moving mechanical optical parts. Further, the narrow spectral response and signal-to-noise are adequate for use of the split-grating-gated QW FET in a passive, multispectral terahertz imaging system. The detector can be operated in a photoconductive or a photovoltaic mode. Other embodiments include uniform front and back gates to independently vary the carrier densities in the channel region, a thinned substrate to increase bolometric responsivity, and a resistive shunt to connect the fingers of the grating gate in parallel and provide a uniform gate-channel voltage along the length of the channel to increase the responsivity and improve the spectral resolution.

  15. Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.

    PubMed

    Yano, Shuya; Takehara, Kiyoto; Zhao, Ming; Tan, Yuying; Han, Qinghong; Li, Shukuan; Bouvet, Michael; Fujiwara, Toshiyoshi; Hoffman, Robert M

    2016-07-01

    We previously reported real-time monitoring of cell cycle dynamics of cancer cells throughout a live tumor intravitally using a fluorescence ubiquitination cell cycle indicator (FUCCI). Approximately 90% of cancer cells in the center and 80% of total cells of an established tumor are in G0/G1 phase. Longitudinal real-time FUCCI imaging demonstrated that cytotoxic agents killed only proliferating cancer cells at the surface and, in contrast, and had little effect on the quiescent cancer cells. Resistant quiescent cancer cells restarted cycling after the cessation of chemotherapy. Thus cytotoxic chemotherapy which targets cells in S/G2/M, is mostly ineffective on solid tumors, but causes toxic side effects on tissues with high fractions of cycling cells, such as hair follicles, bone marrow and the intestinal lining. We have termed this phenomenon tumor intrinsic chemoresistance (TIC). We previously demonstrated that tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R) decoyed quiescent cancer cells in tumors to cycle from G0/G1 to S/G2/M demonstrated by FUCCI imaging. We have also previously shown that when cancer cells were treated with recombinant methioninase (rMETase), the cancer cells were selectively trapped in S/G2, shown by cell sorting as well as by FUCCI. In the present study, we show that sequential treatment of FUCCI-expressing stomach cancer MKN45 in vivo with S. typhimurium A1-R to decoy quiescent cancer cells to cycle, with subsequent rMETase to selectively trap the decoyed cancer cells in S/G2 phase, followed by cisplatinum (CDDP) or paclitaxel (PTX) chemotherapy to kill the decoyed and trapped cancer cells completely prevented or regressed tumor growth. These results demonstrate the effectiveness of the praradigm of "decoy, trap and shoot" chemotherapy. PMID:27152859

  16. Thermodynamics of Weakly Measured Quantum Systems.

    PubMed

    Alonso, Jose Joaquin; Lutz, Eric; Romito, Alessandro

    2016-02-26

    We consider continuously monitored quantum systems and introduce definitions of work and heat along individual quantum trajectories that are valid for coherent superposition of energy eigenstates. We use these quantities to extend the first and second laws of stochastic thermodynamics to the quantum domain. We illustrate our results with the case of a weakly measured driven two-level system and show how to distinguish between quantum work and heat contributions. We finally employ quantum feedback control to suppress detector backaction and determine the work statistics. PMID:26967399

  17. Thermodynamics of Weakly Measured Quantum Systems

    NASA Astrophysics Data System (ADS)

    Alonso, Jose Joaquin; Lutz, Eric; Romito, Alessandro

    2016-02-01

    We consider continuously monitored quantum systems and introduce definitions of work and heat along individual quantum trajectories that are valid for coherent superposition of energy eigenstates. We use these quantities to extend the first and second laws of stochastic thermodynamics to the quantum domain. We illustrate our results with the case of a weakly measured driven two-level system and show how to distinguish between quantum work and heat contributions. We finally employ quantum feedback control to suppress detector backaction and determine the work statistics.

  18. Thermodynamics of Weakly Measured Quantum Systems.

    PubMed

    Alonso, Jose Joaquin; Lutz, Eric; Romito, Alessandro

    2016-02-26

    We consider continuously monitored quantum systems and introduce definitions of work and heat along individual quantum trajectories that are valid for coherent superposition of energy eigenstates. We use these quantities to extend the first and second laws of stochastic thermodynamics to the quantum domain. We illustrate our results with the case of a weakly measured driven two-level system and show how to distinguish between quantum work and heat contributions. We finally employ quantum feedback control to suppress detector backaction and determine the work statistics.

  19. Playing a quantum game with a qutrit

    SciTech Connect

    Sinha, Urbasi; Kolenderski, Piotr; Youning, Li; Zhao, Tong; Volpini, Matthew; Laflamme, Raymond; Jennewein, Thomas; Cabello, Adan

    2014-12-04

    The Aharon Vaidman (AV) quantum game [1] demonstrates the advantage of using simple quantum systems to outperform classical strategies. We present an experimental test of this quantum advantage by using a three-state quantum system (qutrit) encoded in a spatial mode of a single photon passing through a system of three slits [2,3]. We prepare its states by controlling the photon propagation and the number of open and closed slits. We perform POVM measurements by placing detectors in the positions corresponding to near and far field. These tools allow us to perform tomographic reconstructions of qutrit states and play the AV game with compelling evidence of the quantum advantage.

  20. Debugging quantum processes using monitoring measurements

    NASA Astrophysics Data System (ADS)

    Li, Yangjia; Ying, Mingsheng

    2014-04-01

    Since observation on a quantum system may cause the system state collapse, it is usually hard to find a way to monitor a quantum process, which is a quantum system that continuously evolves. We propose a protocol that can debug a quantum process by monitoring, but not disturb the evolution of the system. This protocol consists of an error detector and a debugging strategy. The detector is a projection operator that is orthogonal to the anticipated system state at a sequence of time points, and the strategy is used to specify these time points. As an example, we show how to debug the computational process of quantum search using this protocol. By applying the Skolem-Mahler-Lech theorem in algebraic number theory, we find an algorithm to construct all of the debugging protocols for quantum processes of time-independent Hamiltonians.

  1. Improved Scintillator Materials for Compact Electron Antineutrino Detectors

    SciTech Connect

    Dijkstra, Peter; Wortche, Heinrich J.; Browne, Wesley R.

    2011-04-27

    Developments in the fields of chemistry and materials science provide new components that hold the potential to improve the performance of liquid scintillation electron antineutrino detectors used for the monitoring of nuclear reactors. New compounds can provide for more efficient, stable, and safer operation of these detectors. Current detectors and their detector materials raise issues regarding size, quantum efficiency, stability, and spatial resolution for the vertex detection. For compact detectors (1 m{sup 3} active volume) improvement of these issues with existing liquid scintillation cocktails can be obtained by means of developing stable and efficient neutron capture agents. These agents comprise of boron or lithium containing coordination compounds, in addition advances in fluorescence detection technologies and optimization of solvent characteristics can improve the overall efficiency. Focus points of the new detector material design are to enable a compact, robust, and direction sensitive electron antineutrino detector.

  2. Monolithic short wave infrared (SWIR) detector array

    NASA Technical Reports Server (NTRS)

    1983-01-01

    A monolithic self-scanned linear detector array was developed for remote sensing in the 1.1- 2.4-micron spectral region. A high-density IRCCD test chip was fabricated to verify new design approaches required for the detector array. The driving factors in the Schottky barrier IRCCD (Pdsub2Si) process development are the attainment of detector yield, uniformity, adequate quantum efficiency, and lowest possible dark current consistent with radiometric accuracy. A dual-band module was designed that consists of two linear detector arrays. The sensor architecture places the floating diffusion output structure in the middle of the chip, away from the butt edges. A focal plane package was conceptualized and includes a polycrystalline silicon substrate carrying a two-layer, thick-film interconnecting conductor pattern and five epoxy-mounted modules. A polycrystalline silicon cover encloses the modules and bond wires, and serves as a radiation and EMI shield, thermal conductor, and contamination seal.

  3. The data aggregation problem in quantum hypothesis testing

    NASA Astrophysics Data System (ADS)

    Cialdi, Simone; Paris, Matteo G. A.

    2015-01-01

    We discuss the implications of quantum-classical Yule-Simpson effect for quantum hypothesis testing in the presence of noise, and provide an experimental demonstration of its occurrence in the problem of discriminating which polarization quantum measurement has been actually performed by a detector box designed to measure linear polarization of single-photon states along a fixed but unknown direction.

  4. Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to its soluble decoy receptor IL-22BP

    PubMed Central

    Watanabe, Leandra; de Moura, Patricia Ribeiro; Nascimento, Alessandro Silva; Colau, Didier; Dumoutier, Laure; Renauld, Jean-Christophe; Polikarpov, Igor

    2009-01-01

    Interleukin-22 (IL-22) is a pleiotropic cytokine that is involved in inflammatory responses. Human IL-22 was incubated with its soluble decoy receptor IL-22BP (IL-22 binding protein) and the IL-22–IL-22BP complex was crystallized in hanging drops using the vapour-diffusion method. Suitable crystals were obtained from polyethylene glycol solutions and diffraction data were collected to 2.75 Å resolution. The crystal belonged to the tetragonal space group P41, with unit-cell parameters a = b = 67.9, c = 172.5 Å, and contained two IL-22–IL-­22BP complexes per asymmetric unit. PMID:19193995

  5. Importance of the pharmacological profile of the bound ligand in enrichment on nuclear receptors: toward the use of experimentally validated decoy ligands.

    PubMed

    Lagarde, Nathalie; Zagury, Jean-François; Montes, Matthieu

    2014-10-27

    The evaluation of virtual ligand screening methods is of major importance to ensure their reliability. Taking into account the agonist/antagonist pharmacological profile should improve the quality of the benchmarking data sets since ligand binding can induce conformational changes in the nuclear receptor structure and such changes may vary according to the agonist/antagonist ligand profile. We indeed found that splitting the agonist and antagonist ligands into two separate data sets for a given nuclear receptor target significantly enhances the quality of the evaluation. The pharmacological profile of the ligand bound in the binding site of the target structure was also found to be an additional critical parameter. We also illustrate that active compound data sets for a given pharmacological activity can be used as a set of experimentally validated decoy ligands for another pharmacological activity to ensure a reliable and challenging evaluation of virtual screening methods.

  6. Detector simulation needs for detector designers

    SciTech Connect

    Hanson, G.G.

    1987-11-01

    Computer simulation of the components of SSC detectors and of the complete detectors will be very important for the designs of the detectors. The ratio of events from interesting physics to events from background processes is very low, so detailed understanding of detector response to the backgrounds is needed. Any large detector for the SSC will be very complex and expensive and every effort must be made to design detectors which will have excellent performance and will not have to undergo major rebuilding. Some areas in which computer simulation is particularly needed are pattern recognition in tracking detectors and development of shower simulation code which can be trusted as an aid in the design and optimization of calorimeters, including their electron identification performance. Existing codes require too much computer time to be practical and need to be compared with test beam data at energies of several hundred GeV. Computer simulation of the processing of the data, including electronics response to the signals from the detector components, processing of the data by microprocessors on the detector, the trigger, and data acquisition will be required. In this report we discuss the detector simulation needs for detector designers.

  7. Quantum Communication

    NASA Astrophysics Data System (ADS)

    Weinfurter, Harald; Zeilinger, Anton

    Quantum entanglement lies at the heart of the new field of quantum communication and computation. For a long time, entanglement was seen just as one of those fancy features which make quantum mechanics so counterintuitive. But recently, quantum information theory has shown the tremendous importance of quantum correlations for the formulation of new methods of information transfer and for algorithms exploiting the capabilities of quantum computers.This chapter describes the first experimental realizations of quantum communication schemes using entangled photon pairs. We show how to make communication secure against eavesdropping using entanglement-based quantum cryptography, how to increase the information capacity of a quantum channel by quantum dense coding and, finally, how to communicate quantum information itself in the process of quantum teleportation.

  8. Type II superlattice technology for LWIR detectors

    NASA Astrophysics Data System (ADS)

    Klipstein, P. C.; Avnon, E.; Azulai, D.; Benny, Y.; Fraenkel, R.; Glozman, A.; Hojman, E.; Klin, O.; Krasovitsky, L.; Langof, L.; Lukomsky, I.; Nitzani, M.; Shtrichman, I.; Rappaport, N.; Snapi, N.; Weiss, E.; Tuito, A.

    2016-05-01

    SCD has developed a range of advanced infrared detectors based on III-V semiconductor heterostructures grown on GaSb. The XBn/XBp family of barrier detectors enables diffusion limited dark currents, comparable with MCT Rule-07, and high quantum efficiencies. This work describes some of the technical challenges that were overcome, and the ultimate performance that was finally achieved, for SCD's new 15 μm pitch "Pelican-D LW" type II superlattice (T2SL) XBp array detector. This detector is the first of SCD's line of high performance two dimensional arrays working in the LWIR spectral range, and was designed with a ~9.3 micron cut-off wavelength and a format of 640 x 512 pixels. It contains InAs/GaSb and InAs/AlSb T2SLs, engineered using k • p modeling of the energy bands and photo-response. The wafers are grown by molecular beam epitaxy and are fabricated into Focal Plane Array (FPA) detectors using standard FPA processes, including wet and dry etching, indium bump hybridization, under-fill, and back-side polishing. The FPA has a quantum efficiency of nearly 50%, and operates at 77 K and F/2.7 with background limited performance. The pixel operability of the FPA is above 99% and it exhibits a stable residual non uniformity (RNU) of better than 0.04% of the dynamic range. The FPA uses a new digital read-out integrated circuit (ROIC), and the complete detector closely follows the interfaces of SCD's MWIR Pelican-D detector. The Pelican- D LW detector is now in the final stages of qualification and transfer to production, with first prototypes already integrated into new electro-optical systems.

  9. Applications of quantum cloning

    NASA Astrophysics Data System (ADS)

    Pomarico, E.; Sanguinetti, B.; Sekatski, P.; Zbinden, H.; Gisin, N.

    2011-10-01

    Quantum Cloning Machines (QCMs) allow for the copying of information, within the limits imposed by quantum mechanics. These devices are particularly interesting in the high-gain regime, i.e., when one input qubit generates a state of many output qubits. In this regime, they allow for the study of certain aspects of the quantum to classical transition. The understanding of these aspects is the root of the two recent applications that we will review in this paper: the first one is the Quantum Cloning Radiometer, a device which is able to produce an absolute measure of spectral radiance. This device exploits the fact that in the quantum regime information can be copied with only finite fidelity, whereas when a state becomes macroscopic, this fidelity gradually increases to 1. Measuring the fidelity of the cloning operation then allows to precisely determine the absolute spectral radiance of the input optical source. We will then discuss whether a Quantum Cloning Machine could be used to produce a state visible by the naked human eye, and the possibility of a Bell Experiment with humans playing the role of detectors.

  10. Spiral silicon drift detectors

    SciTech Connect

    Rehak, P.; Gatti, E.; Longoni, A.; Sampietro, M.; Holl, P.; Lutz, G.; Kemmer, J.; Prechtel, U.; Ziemann, T.

    1988-01-01

    An advanced large area silicon photodiode (and x-ray detector), called Spiral Drift Detector, was designed, produced and tested. The Spiral Detector belongs to the family of silicon drift detectors and is an improvement of the well known Cylindrical Drift Detector. In both detectors, signal electrons created in silicon by fast charged particles or photons are drifting toward a practically point-like collection anode. The capacitance of the anode is therefore kept at the minimum (0.1pF). The concentric rings of the cylindrical detector are replaced by a continuous spiral in the new detector. The spiral geometry detector design leads to a decrease of the detector leakage current. In the spiral detector all electrons generated at the silicon-silicon oxide interface are collected on a guard sink rather than contributing to the detector leakage current. The decrease of the leakage current reduces the parallel noise of the detector. This decrease of the leakage current and the very small capacities of the detector anode with a capacitively matched preamplifier may improve the energy resolution of Spiral Drift Detectors operating at room temperature down to about 50 electrons rms. This resolution is in the range attainable at present only by cooled semiconductor detectors. 5 refs., 10 figs.

  11. Two-party quantum key agreement against collective noise

    NASA Astrophysics Data System (ADS)

    He, Ye-Feng; Ma, Wen-Ping

    2016-09-01

    In this paper, two two-party quantum key agreement protocols are proposed with logical χ -states and logical Bell states. These two protocols can be immune to the collective-dephasing noise and the collective-rotation noise, respectively. They make full use of the measurement correlation property of multi-particle entangled states and the delayed measurement technique. This ensures that two participants can exchange the secret keys of each other and fairly establishes a shared key. There is no information leakage problem when establishing a shared key. The use of the delayed measurement technique and the decoy state technology makes the two protocols resist against both participant and outsider attacks. Furthermore, the two protocols are congenitally free from the Trojan horse attacks and have high qubit efficiency.

  12. Quantum interference in plasmonic circuits

    NASA Astrophysics Data System (ADS)

    Heeres, Reinier W.; Kouwenhoven, Leo P.; Zwiller, Valery

    2013-10-01

    Surface plasmon polaritons (plasmons) are a combination of light and a collective oscillation of the free electron plasma at metal/dielectric interfaces. This interaction allows subwavelength confinement of light beyond the diffraction limit inherent to dielectric structures. As a result, the intensity of the electromagnetic field is enhanced, with the possibility to increase the strength of the optical interactions between waveguides, light sources and detectors. Plasmons maintain non-classical photon statistics and preserve entanglement upon transmission through thin, patterned metallic films or weakly confining waveguides. For quantum applications, it is essential that plasmons behave as indistinguishable quantum particles. Here we report on a quantum interference experiment in a nanoscale plasmonic circuit consisting of an on-chip plasmon beamsplitter with integrated superconducting single-photon detectors to allow efficient single plasmon detection. We demonstrate a quantum-mechanical interaction between pairs of indistinguishable surface plasmons by observing Hong-Ou-Mandel (HOM) interference, a hallmark non-classical interference effect that is the basis of linear optics-based quantum computation. Our work shows that it is feasible to shrink quantum optical experiments to the nanoscale and offers a promising route towards subwavelength quantum optical networks.

  13. POVM Receivers for Quantum Cryptography

    NASA Astrophysics Data System (ADS)

    Brandt, H. E.

    1997-04-01

    Positive operator valued measures (POVMs) are finding increasing use in quantum cryptography.(A. Peres, Quantum Theory: Concepts and Methods, Kluwer Academic Publishers, Boston (1993).) I present quantum circuit analyses of two recently proposed (H. E. Brandt, J. M. Myers, and S. J. Lomonaco Jr., "New Results in Entangled Translucent Eavesdropping in Quantum Cryptography," in Photonic Quantum Computing, S. P. Hotaling and A. R. Pirich, Editors, Proc. SPIE 3076 (1997)) all-optical designs for POVM receivers to be used in conjunction with Bennett's B92 protocol for key distribution based on two photon polarization states. Expectation values for the POVM operators are calculated and shown to be faithfully realized by the POVM detectors.

  14. Are cloned quantum states macroscopic?

    PubMed

    Fröwis, F; Dür, W

    2012-10-26

    We study quantum states produced by optimal phase covariant quantum cloners. We argue that cloned quantum superpositions are not macroscopic superpositions in the spirit of Schrödinger's cat, despite their large particle number. This is indicated by calculating several measures for macroscopic superpositions from the literature, as well as by investigating the distinguishability of the two superposed cloned states. The latter rapidly diminishes when considering imperfect detectors or noisy states and does not increase with the system size. In contrast, we find that cloned quantum states themselves are macroscopic, in the sense of both proposed measures and their usefulness in quantum metrology with an optimal scaling in system size. We investigate the applicability of cloned states for parameter estimation in the presence of different kinds of noise.

  15. Quantum simulation

    NASA Astrophysics Data System (ADS)

    Georgescu, I. M.; Ashhab, S.; Nori, Franco

    2014-01-01

    Simulating quantum mechanics is known to be a difficult computational problem, especially when dealing with large systems. However, this difficulty may be overcome by using some controllable quantum system to study another less controllable or accessible quantum system, i.e., quantum simulation. Quantum simulation promises to have applications in the study of many problems in, e.g., condensed-matter physics, high-energy physics, atomic physics, quantum chemistry, and cosmology. Quantum simulation could be implemented using quantum computers, but also with simpler, analog devices that would require less control, and therefore, would be easier to construct. A number of quantum systems such as neutral atoms, ions, polar molecules, electrons in semiconductors, superconducting circuits, nuclear spins, and photons have been proposed as quantum simulators. This review outlines the main theoretical and experimental aspects of quantum simulation and emphasizes some of the challenges and promises of this fast-growing field.

  16. Infrared Detectors Containing Stacked Si(1-x)Ge(x)/Si Layers

    NASA Technical Reports Server (NTRS)

    Park, Jin S.; Lin, True-Lon; Jones, Eric; Del Castillo, Hector; Gunapala, Sarath

    1996-01-01

    Long-wavelength-infrared detectors containing multiple layers of high-quality crystalline p(+) Si(1-x)Ge(x) alternating with layers of Si undergoing development. Each detector comprises stack of Si(1-x)Ge(x)/Si heterojunction internal photoemission (HIP) photodetectors. In comparison with older HIP detectors containing single Si(1-x)Ge(x)/Si heterojunctions, developmental detectors feature greater quantum efficiencies and stronger photoresponses.

  17. The SuperCDMS SNOLAB Detector Tower

    NASA Astrophysics Data System (ADS)

    Aramaki, Tsuguo

    2016-08-01

    The SuperCDMS collaboration is moving forward with the design and construction of SuperCDMS SNOLAB, where the initial deployment will include ˜ 30 kg of Ge and ˜ 5 kg of Si detectors. Here, we will discuss the associated cryogenic cold hardware required for the detector readout. The phonon signals will be read out with superconducting quantum interference device arrays and the ionization signals will use high electron mobility transistor amplifiers operating at 4 K. A number of design challenges exist regarding the required wiring complex impedance, noise pickup, vibration, and thermal isolation. Our progress to date will be presented.

  18. Advances in Detector Technology for Infrared Astronomy

    NASA Technical Reports Server (NTRS)

    McCreight, Craig; Cheng, P. L. (Technical Monitor)

    1995-01-01

    Progress in semiconductor materials and processing technology has allowed the development of infrared detector arrays with unprecedented sensitivity, for imaging and spectroscopic applications in astronomy. The earlier discrete-detector approach has been replaced by large-element (up to 1024 x 1024 pixel), multiplexed devices. Progress has been made against a number of key limiting factors, such as quantum efficiency, noise, spectral response, linearity, and dark current. Future developments will focus on the need for even larger arrays, which operate at higher temperatures.

  19. Irreversible degradation of quantum coherence under relativistic motion

    NASA Astrophysics Data System (ADS)

    Wang, Jieci; Tian, Zehua; Jing, Jiliang; Fan, Heng

    2016-06-01

    We study the dynamics of quantum coherence under Unruh thermal noise and seek under which condition the coherence can be frozen in a relativistic setting. We find that the frozen condition is either (i) the initial state is prepared as an incoherence state or (ii) the detectors have no interaction with the external field. That is to say, the decoherence of the detectors' quantum state is irreversible under the influence of thermal noise induced by Unruh radiation. It is shown that quantum coherence approaches zero only in the limit of an infinite acceleration, while quantum entanglement could reduce to zero for a finite acceleration. It is also demonstrated that the robustness of quantum coherence is better than entanglement under the influence of the atom-field interaction for an extremely large acceleration. Therefore, quantum coherence is more robust than entanglement in an accelerating system and the coherence-type quantum resources are more accessible for relativistic quantum information processing tasks.

  20. Secure satellite communication using multi-photon tolerant quantum communication protocol

    NASA Astrophysics Data System (ADS)

    Darunkar, Bhagyashri; Punekar, Nikhil; Verma, Pramode K.

    2015-09-01

    This paper proposes and analyzes the potential of a multi-photon tolerant quantum communication protocol to secure satellite communication. For securing satellite communication, quantum cryptography is the only known unconditionally secure method. A number of recent experiments have shown feasibility of satellite-aided global quantum key distribution (QKD) using different methods such as: Use of entangled photon pairs, decoy state methods, and entanglement swapping. The use of single photon in these methods restricts the distance and speed over which quantum cryptography can be applied. Contemporary quantum cryptography protocols like the BB84 and its variants suffer from the limitation of reaching the distances of only Low Earth Orbit (LEO) at the data rates of few kilobits per second. This makes it impossible to develop a general satellite-based secure global communication network using the existing protocols. The method proposed in this paper allows secure communication at the heights of the Medium Earth Orbit (MEO) and Geosynchronous Earth Orbit (GEO) satellites. The benefits of the proposed method are two-fold: First it enables the realization of a secure global communication network based on satellites and second it provides unconditional security for satellite networks at GEO heights. The multi-photon approach discussed in this paper ameliorates the distance and speed issues associated with quantum cryptography through the use of contemporary laser communication (lasercom) devices. This approach can be seen as a step ahead towards global quantum communication.

  1. A scheme for efficient quantum computation with linear optics

    NASA Astrophysics Data System (ADS)

    Knill, E.; Laflamme, R.; Milburn, G. J.

    2001-01-01

    Quantum computers promise to increase greatly the efficiency of solving problems such as factoring large integers, combinatorial optimization and quantum physics simulation. One of the greatest challenges now is to implement the basic quantum-computational elements in a physical system and to demonstrate that they can be reliably and scalably controlled. One of the earliest proposals for quantum computation is based on implementing a quantum bit with two optical modes containing one photon. The proposal is appealing because of the ease with which photon interference can be observed. Until now, it suffered from the requirement for non-linear couplings between optical modes containing few photons. Here we show that efficient quantum computation is possible using only beam splitters, phase shifters, single photon sources and photo-detectors. Our methods exploit feedback from photo-detectors and are robust against errors from photon loss and detector inefficiency. The basic elements are accessible to experimental investigation with current technology.

  2. Quantum ontologies

    SciTech Connect

    Stapp, H.P.

    1988-12-01

    Quantum ontologies are conceptions of the constitution of the universe that are compatible with quantum theory. The ontological orientation is contrasted to the pragmatic orientation of science, and reasons are given for considering quantum ontologies both within science, and in broader contexts. The principal quantum ontologies are described and evaluated. Invited paper at conference: Bell's Theorem, Quantum Theory, and Conceptions of the Universe, George Mason University, October 20-21, 1988. 16 refs.

  3. Controlled quantum secure direct communication by entanglement distillation or generalized measurement

    NASA Astrophysics Data System (ADS)

    Tan, Xiaoqing; Zhang, Xiaoqian

    2016-05-01

    We propose two controlled quantum secure communication schemes by entanglement distillation or generalized measurement. The sender Alice, the receiver Bob and the controllers David and Cliff take part in the whole schemes. The supervisors David and Cliff can control the information transmitted from Alice to Bob by adjusting the local measurement angles θ _4 and θ _3. Bob can verify his secret information by classical one-way function after communication. The average amount of information is analyzed and compared for these two methods by MATLAB. The generalized measurement is a better scheme. Our schemes are secure against some well-known attacks because classical encryption and decoy states are used to ensure the security of the classical channel and the quantum channel.

  4. Robust Anti-Collective Noise Quantum Secure Direct Dialogue Using Logical Bell States

    NASA Astrophysics Data System (ADS)

    Wu, Di; Lv, Hong-Jun; Xie, Guang-Jun

    2016-01-01

    In this paper we propose two quantum secure direct dialogue (QSDD) schemes with logical Bell states which can resist collective noise. The two users Alice and Bob encode their secret messages with the help of unitary operations. Compared with many quantum secure direct communication (QSDC), there is no strict information sender and receiver in these schemes, one logical Bell state can be operated twice by Alice and Bob based on what messages they prefer to encode. As a result, the two users are able to share their messages mutually, so the efficiency of communication is improved. By rearranging the order of particles and inserting decoy photons, our protocols are able to avoid the information leakage and detect eavesdropping, and they can be proved to have unconditional security.

  5. Quantum oblivion: A master key for many quantum riddles

    NASA Astrophysics Data System (ADS)

    Elitzur, Avshalom C.; Cohen, Eliahu

    2014-02-01

    A simple quantum interaction is analyzed, where the paths of two superposed particles asymmetrically cross, while a detector set to detect an interaction between them remains silent. Despite this negative result, the particles' states leave no doubt that a peculiar interaction has occurred: One particle's momentum is changed while the other's remains unaffected, in apparent violation of momentum conservation. Revisiting the foundations of the standard quantum measurement process offers the resolution. Prior to the macroscopic recording of no interaction, a brief critical interval (CI) prevails, during which the particles and the detector's pointer form a subtle entanglement which immediately dissolves. It is this self-cancellation, henceforth "quantum oblivion (QO)," that lies at the basis of some well-known intriguing quantum effects. Such is interaction-free measurement (IFM)1 and its more paradoxical variants like Hardy's Paradox2 and the quantum liar paradox.3 Even the Aharonov-Bohm (AB) effect4 and weak measurement (WM)5 turn out to belong to this group. We next study interventions within the CI that produce some other peculiar effects. Finally, we discuss some of the conceptual issues involved. Under a greater time-resolution of the CI, some non-local phenomena turn out to be local. Momentum is conserved due to the quantum uncertainties inflicted by the particle-pointer interaction, which sets the experiment's final boundary condition.

  6. The TALE Tower Detector

    NASA Astrophysics Data System (ADS)

    Bergman, D. R.

    The TA Low Energy Extension will include a Tower FluorescenceDetector. Extensive air showers at the lowest usful energies for fluorescence detectors will in general be close to the detector. This requires viewing all elevation angles to be able to reconstruct showers. The TALE Tower Detector, operating in conjunction with other TALE detectors will view elevation angles up to above 70 degrees, with an azimuthal coverage of about 90 degrees. Results from a prototype mirror operated in conjunction with the HiRes detector will also be presented.

  7. GADRAS Detector Response Function.

    SciTech Connect

    Mitchell, Dean J.; Harding, Lee; Thoreson, Gregory G; Horne, Steven M.

    2014-11-01

    The Gamma Detector Response and Analysis Software (GADRAS) applies a Detector Response Function (DRF) to compute the output of gamma-ray and neutron detectors when they are exposed to radiation sources. The DRF is fundamental to the ability to perform forward calculations (i.e., computation of the response of a detector to a known source), as well as the ability to analyze spectra to deduce the types and quantities of radioactive material to which the detectors are exposed. This document describes how gamma-ray spectra are computed and the significance of response function parameters that define characteristics of particular detectors.

  8. The upgraded DØ detector

    NASA Astrophysics Data System (ADS)

    Abazov, V. M.; Abbott, B.; Abolins, M.; Acharya, B. S.; Adams, D. L.; Adams, M.; Adams, T.; Agelou, M.; Agram, J.-L.; Ahmed, S. N.; Ahn, S. H.; Ahsan, M.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Alverson, G.; Alves, G. A.; Anastasoaie, M.; Andeen, T.; Anderson, J. T.; Anderson, S.; Andrieu, B.; Angstadt, R.; Anosov, V.; Arnoud, Y.; Arov, M.; Askew, A.; Åsman, B.; Assis Jesus, A. C. S.; Atramentov, O.; Autermann, C.; Avila, C.; Babukhadia, L.; Bacon, T. C.; Badaud, F.; Baden, A.; Baffioni, S.; Bagby, L.; Baldin, B.; Balm, P. W.; Banerjee, P.; Banerjee, S.; Barberis, E.; Bardon, O.; Barg, W.; Bargassa, P.; Baringer, P.; Barnes, C.; Barreto, J.; Bartlett, J. F.; Bassler, U.; Bhattacharjee, M.; Baturitsky, M. A.; Bauer, D.; Bean, A.; Baumbaugh, B.; Beauceron, S.; Begalli, M.; Beaudette, F.; Begel, M.; Bellavance, A.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Besson, A.; Beuselinck, R.; Beutel, D.; Bezzubov, V. A.; Bhat, P. C.; Bhatnagar, V.; Binder, M.; Biscarat, C.; Bishoff, A.; Black, K. M.; Blackler, I.; Blazey, G.; Blekman, F.; Blessing, S.; Bloch, D.; Blumenschein, U.; Bockenthien, E.; Bodyagin, V.; Boehnlein, A.; Boeriu, O.; Bolton, T. A.; Bonamy, P.; Bonifas, D.; Borcherding, F.; Borissov, G.; Bos, K.; Bose, T.; Boswell, C.; Bowden, M.; Brandt, A.; Briskin, G.; Brock, R.; Brooijmans, G.; Bross, A.; Buchanan, N. J.; Buchholz, D.; Buehler, M.; Buescher, V.; Burdin, S.; Burke, S.; Burnett, T. H.; Busato, E.; Buszello, C. P.; Butler, D.; Butler, J. M.; Cammin, J.; Caron, S.; Bystricky, J.; Canal, L.; Canelli, F.; Carvalho, W.; Casey, B. C. K.; Casey, D.; Cason, N. M.; Castilla-Valdez, H.; Chakrabarti, S.; Chakraborty, D.; Chan, K. M.; Chandra, A.; Chapin, D.; Charles, F.; Cheu, E.; Chevalier, L.; Chi, E.; Chiche, R.; Cho, D. K.; Choate, R.; Choi, S.; Choudhary, B.; Chopra, S.; Christenson, J. H.; Christiansen, T.; Christofek, L.; Churin, I.; Cisko, G.; Claes, D.; Clark, A. R.; Clément, B.; Clément, C.; Coadou, Y.; Colling, D. J.; Coney, L.; Connolly, B.; Cooke, M.; Cooper, W. E.; Coppage, D.; Corcoran, M.; Coss, J.; Cothenet, A.; Cousinou, M.-C.; Cox, B.; Crépé-Renaudin, S.; Cristetiu, M.; Cummings, M. A. C.; Cutts, D.; da Motta, H.; Das, M.; Davies, B.; Davies, G.; Davis, G. A.; Davis, W.; De, K.; de Jong, P.; de Jong, S. J.; De La Cruz-Burelo, E.; De La Taille, C.; De Oliveira Martins, C.; Dean, S.; Degenhardt, J. D.; Déliot, F.; Delsart, P. A.; Del Signore, K.; DeMaat, R.; Demarteau, M.; Demina, R.; Demine, P.; Denisov, D.; Denisov, S. P.; Desai, S.; Diehl, H. T.; Diesburg, M.; Doets, M.; Doidge, M.; Dong, H.; Doulas, S.; Dudko, L. V.; Duflot, L.; Dugad, S. R.; Duperrin, A.; Dvornikov, O.; Dyer, J.; Dyshkant, A.; Eads, M.; Edmunds, D.; Edwards, T.; Ellison, J.; Elmsheuser, J.; Eltzroth, J. T.; Elvira, V. D.; Eno, S.; Ermolov, P.; Eroshin, O. V.; Estrada, J.; Evans, D.; Evans, H.; Evdokimov, A.; Evdokimov, V. N.; Fagan, J.; Fast, J.; Fatakia, S. N.; Fein, D.; Feligioni, L.; Ferapontov, A. V.; Ferbel, T.; Ferreira, M. J.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fleck, I.; Fitzpatrick, T.; Flattum, E.; Fleuret, F.; Flores, R.; Foglesong, J.; Fortner, M.; Fox, H.; Franklin, C.; Freeman, W.; Fu, S.; Fuess, S.; Gadfort, T.; Galea, C. F.; Gallas, E.; Galyaev, E.; Gao, M.; Garcia, C.; Garcia-Bellido, A.; Gardner, J.; Gavrilov, V.; Gay, A.; Gay, P.; Gelé, D.; Gelhaus, R.; Genser, K.; Gerber, C. E.; Gershtein, Y.; Gillberg, D.; Geurkov, G.; Ginther, G.; Gobbi, B.; Goldmann, K.; Golling, T.; Gollub, N.; Golovtsov, V.; Gómez, B.; Gomez, G.; Gomez, R.; Goodwin, R.; Gornushkin, Y.; Gounder, K.; Goussiou, A.; Graham, D.; Graham, G.; Grannis, P. D.; Gray, K.; Greder, S.; Green, D. R.; Green, J.; Green, J. A.; Greenlee, H.; Greenwood, Z. D.; Gregores, E. M.; Grinstein, S.; Gris, Ph.; Grivaz, J.-F.; Groer, L.; Grünendahl, S.; Grünewald, M. W.; Gu, W.; Guglielmo, J.; Gupta, A.; Gurzhiev, S. N.; Gutierrez, G.; Gutierrez, P.; Haas, A.; Hadley, N. J.; Haggard, E.; Haggerty, H.; Hagopian, S.; Hall, I.; Hall, R. E.; Han, C.; Han, L.; Hance, R.; Hanagaki, K.; Hanlet, P.; Hansen, S.; Harder, K.; Harel, A.; Harrington, R.; Hauptman, J. M.; Hauser, R.; Hays, C.; Hays, J.; Hazen, E.; Hebbeker, T.; Hebert, C.; Hedin, D.; Heinmiller, J. M.; Heinson, A. P.; Heintz, U.; Hensel, C.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hobbs, J. D.; Hoeneisen, B.; Hohlfeld, M.; Hong, S. J.; Hooper, R.; Hou, S.; Houben, P.; Hu, Y.; Huang, J.; Huang, Y.; Hynek, V.; Huffman, D.; Iashvili, I.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jacquier, Y.; Jaffré, M.; Jain, S.; Jain, V.; Jakobs, K.; Jayanti, R.; Jenkins, A.; Jesik, R.; Jiang, Y.; Johns, K.; Johnson, M.; Johnson, P.; Jonckheere, A.; Jonsson, P.; Jöstlein, H.; Jouravlev, N.; Juarez, M.; Juste, A.; Kaan, A. P.; Kado, M. M.; Käfer, D.; Kahl, W.; Kahn, S.; Kajfasz, E.; Kalinin, A. M.; Kalk, J.; Kalmani, S. D.; Karmanov, D.; Kasper, J.; Katsanos, I.; Kau, D.; Kaur, R.; Ke, Z.; Kehoe, R.; Kermiche, S.; Kesisoglou, S.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. M.; Kim, H.; Kim, K. H.; Kim, T. J.; Kirsch, N.; Klima, B.; Klute, M.; Kohli, J. M.; Konrath, J.-P.; Komissarov, E. V.; Kopal, M.; Korablev, V. M.; Kostritski, A.; Kotcher, J.; Kothari, B.; Kotwal, A. V.; Koubarovsky, A.; Kozelov, A. V.; Kozminski, J.; Kryemadhi, A.; Kouznetsov, O.; Krane, J.; Kravchuk, N.; Krempetz, K.; Krider, J.; Krishnaswamy, M. R.; Krzywdzinski, S.; Kubantsev, M.; Kubinski, R.; Kuchinsky, N.; Kuleshov, S.; Kulik, Y.; Kumar, A.; Kunori, S.; Kupco, A.; Kurča, T.; Kvita, J.; Kuznetsov, V. E.; Kwarciany, R.; Lager, S.; Lahrichi, N.; Landsberg, G.; Larwill, M.; Laurens, P.; Lavigne, B.; Lazoflores, J.; Le Bihan, A.-C.; Le Meur, G.; Lebrun, P.; Lee, S. W.; Lee, W. M.; Leflat, A.; Leggett, C.; Lehner, F.; Leitner, R.; Leonidopoulos, C.; Leveque, J.; Lewis, P.; Li, J.; Li, Q. Z.; Li, X.; Lima, J. G. R.; Lincoln, D.; Lindenmeyer, C.; Linn, S. L.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Litmaath, M.; Lizarazo, J.; Lobo, L.; Lobodenko, A.; Lokajicek, M.; Lounis, A.; Love, P.; Lu, J.; Lubatti, H. J.; Lucotte, A.; Lueking, L.; Luo, C.; Lynker, M.; Lyon, A. L.; Machado, E.; Maciel, A. K. A.; Madaras, R. J.; Mättig, P.; Magass, C.; Magerkurth, A.; Magnan, A.-M.; Maity, M.; Makovec, N.; Mal, P. K.; Malbouisson, H. B.; Malik, S.; Malyshev, V. L.; Manakov, V.; Mao, H. S.; Maravin, Y.; Markley, D.; Markus, M.; Marshall, T.; Martens, M.; Martin, M.; Martin-Chassard, G.; Mattingly, S. E. K.; Matulik, M.; Mayorov, A. A.; McCarthy, R.; McCroskey, R.; McKenna, M.; McMahon, T.; Meder, D.; Melanson, H. L.; Melnitchouk, A.; Mendes, A.; Mendoza, D.; Mendoza, L.; Meng, X.; Merekov, Y. P.; Merkin, M.; Merritt, K. W.; Meyer, A.; Meyer, J.; Michaut, M.; Miao, C.; Miettinen, H.; Mihalcea, D.; Mikhailov, V.; Miller, D.; Mitrevski, J.; Mokhov, N.; Molina, J.; Mondal, N. K.; Montgomery, H. E.; Moore, R. W.; Moulik, T.; Muanza, G. S.; Mostafa, M.; Moua, S.; Mulders, M.; Mundim, L.; Mutaf, Y. D.; Nagaraj, P.; Nagy, E.; Naimuddin, M.; Nang, F.; Narain, M.; Narasimhan, V. S.; Narayanan, A.; Naumann, N. A.; Neal, H. A.; Negret, J. P.; Nelson, S.; Neuenschwander, R. T.; Neustroev, P.; Noeding, C.; Nomerotski, A.; Novaes, S. F.; Nozdrin, A.; Nunnemann, T.; Nurczyk, A.; Nurse, E.; O'Dell, V.; O'Neil, D. C.; Oguri, V.; Olis, D.; Oliveira, N.; Olivier, B.; Olsen, J.; Oshima, N.; Oshinowo, B. O.; Otero y Garzón, G. J.; Padley, P.; Papageorgiou, K.; Parashar, N.; Park, J.; Park, S. K.; Parsons, J.; Partridge, R.; Parua, N.; Patwa, A.; Pawloski, G.; Perea, P. M.; Perez, E.; Peters, O.; Pétroff, P.; Petteni, M.; Phaf, L.; Piegaia, R.; Pleier, M.-A.; Podesta-Lerma, P. L. M.; Podstavkov, V. M.; Pogorelov, Y.; Pol, M.-E.; Pompoš, A.; Polosov, P.; Pope, B. G.; Popkov, E.; Porokhovoy, S.; Prado da Silva, W. L.; Pritchard, W.; Prokhorov, I.; Prosper, H. B.; Protopopescu, S.; Przybycien, M. B.; Qian, J.; Quadt, A.; Quinn, B.; Ramberg, E.; Ramirez-Gomez, R.; Rani, K. J.; Ranjan, K.; Rao, M. V. S.; Rapidis, P. A.; Rapisarda, S.; Raskowski, J.; Ratoff, P. N.; Ray, R. E.; Reay, N. W.; Rechenmacher, R.; Reddy, L. V.; Regan, T.; Renardy, J.-F.; Reucroft, S.; Rha, J.; Ridel, M.; Rijssenbeek, M.; Ripp-Baudot, I.; Rizatdinova, F.; Robinson, S.; Rodrigues, R. F.; Roco, M.; Rotolo, C.; Royon, C.; Rubinov, P.; Ruchti, R.; Rucinski, R.; Rud, V. I.; Russakovich, N.; Russo, P.; Sabirov, B.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santoro, A.; Satyanarayana, B.; Savage, G.; Sawyer, L.; Scanlon, T.; Schaile, D.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schieferdecker, P.; Schmitt, C.; Schwanenberger, C.; Schukin, A. A.; Schwartzman, A.; Schwienhorst, R.; Sengupta, S.; Severini, H.; Shabalina, E.; Shamim, M.; Shankar, H. C.; Shary, V.; Shchukin, A. A.; Sheahan, P.; Shephard, W. D.; Shivpuri, R. K.; Shishkin, A. A.; Shpakov, D.; Shupe, M.; Sidwell, R. A.; Simak, V.; Sirotenko, V.; Skow, D.; Skubic, P.; Slattery, P.; Smith, D. E.; Smith, R. P.; Smolek, K.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Song, X.; Song, Y.; Sonnenschein, L.; Sopczak, A.; Sorín, V.; Sosebee, M.; Soustruznik, K.; Souza, M.; Spartana, N.; Spurlock, B.; Stanton, N. R.; Stark, J.; Steele, J.; Stefanik, A.; Steinberg, J.; Steinbrück, G.; Stevenson, K.; Stolin, V.; Stone, A.; Stoyanova, D. A.; Strandberg, J.; Strang, M. A.; Strauss, M.; Ströhmer, R.; Strom, D.; Strovink, M.; Stutte, L.; Sumowidagdo, S.; Sznajder, A.; Talby, M.; Tentindo-Repond, S.; Tamburello, P.; Taylor, W.; Telford, P.; Temple, J.; Terentyev, N.; Teterin, V.; Thomas, E.; Thompson, J.; Thooris, B.; Titov, M.; Toback, D.; Tokmenin, V. V.; Tolian, C.; Tomoto, M.; Tompkins, D.; Toole, T.; Torborg, J.; Touze, F.; Towers, S.; Trefzger, T.; Trincaz-Duvoid, S.; Trippe, T. G.; Tsybychev, D.; Tuchming, B.; Tully, C.; Turcot, A. S.; Tuts, P. M.; Utes, M.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Vachon, B.; van den Berg, P. J.; van Gemmeren, P.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vartapetian, A.; Vasilyev, I. A.; Vaupel, M.; Vaz, M.; Verdier, P.; Vertogradov, L. S.; Verzocchi, M.; Vigneault, M.; Villeneuve-Seguier, F.; Vishwanath, P. R.; Vlimant, J.-R.; Von Toerne, E.; Vorobyov, A.; Vreeswijk, M.; Vu Anh, T.; Vysotsky, V.; Wahl, H. D.; Walker, R.; Wallace, N.; Wang, L.; Wang, Z.-M.; Warchol, J.; Warsinsky, M.; Watts, G.; Wayne, M.; Weber, M.; Weerts, H.; Wegner, M.; Wermes, N.; Wetstein, M.; White, A.; White, V.; Whiteson, D.; Wicke, D.; Wijnen, T.; Wijngaarden, D. A.; Wilcer, N.; Willutzki, H.; Wilson, G. W.; Wimpenny, S. J.; Wittlin, J.; Wlodek, T.; Wobisch, M.; Womersley, J.; Wood, D. R.; Wyatt, T. R.; Wu, Z.; Xie, Y.; Xu, Q.; Xuan, N.; Yacoob, S.; Yamada, R.; Yan, M.; Yarema, R.; Yasuda, T.; Yatsunenko, Y. A.; Yen, Y.; Yip, K.; Yoo, H. D.; Yoffe, F.; Youn, S. W.; Yu, J.; Yurkewicz, A.; Zabi, A.; Zanabria, M.; Zatserklyaniy, A.; Zdrazil, M.; Zeitnitz, C.; Zhang, B.; Zhang, D.; Zhang, X.; Zhao, T.; Zhao, Z.; Zheng, H.; Zhou, B.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zieminski, A.; Zitoun, R.; Zmuda, T.; Zutshi, V.; Zviagintsev, S.; Zverev, E. G.; Zylberstejn, A.

    2006-09-01

    The DØ experiment enjoyed a very successful data-collection run at the Fermilab Tevatron collider between 1992 and 1996. Since then, the detector has been upgraded to take advantage of improvements to the Tevatron and to enhance its physics capabilities. We describe the new elements of the detector, including the silicon microstrip tracker, central fiber tracker, solenoidal magnet, preshower detectors, forward muon detector, and forward proton detector. The uranium/liquid-argon calorimeters and central muon detector, remaining from Run I, are discussed briefly. We also present the associated electronics, triggering, and data acquisition systems, along with the design and implementation of software specific to DØ.

  9. The MINOS detectors

    SciTech Connect

    Habig, A.; Grashorn, E.W.; /Minnesota U., Duluth

    2005-07-01

    The Main Injector Neutrino Oscillation Search (MINOS) experiment's primary goal is the precision measurement of the neutrino oscillation parameters in the atmospheric neutrino sector. This long-baseline experiment uses Fermilab's NuMI beam, measured with a Near Detector at Fermilab, and again 735 km later using a Far Detector in the Soudan Mine Underground Lab in northern Minnesota. The detectors are magnetized iron/scintillator calorimeters. The Far Detector has been operational for cosmic ray and atmospheric neutrino data from July of 2003, the Near Detector from September 2004, and the NuMI beam started in early 2005. This poster presents details of the two detectors.

  10. Terahertz detection using double quantum well devices

    NASA Astrophysics Data System (ADS)

    Khodier, Majid; Christodoulou, Christos G.; Simmons, Jerry A.

    2001-12-01

    This paper discusses the principle of operation of an electrically tunable THz detector, working around 2.54 THz, integrated with a bowtie antenna. The detection is based on the idea of photon-assisted tunneling (PAT) in a double quantum well (DQW) device. The bowtie antenna is used to collect the THz radiation and feed it to the detector for processing. The Bowtie antenna geometry is integrated with the DQW device to achieve broadband characteristic, easy design, and compatibility with the detector fabrication process. The principle of operation of the detector is introduced first. Then, results of different bowtie antenna layouts are presented and discussed.

  11. Copenhagen quantum mechanics

    NASA Astrophysics Data System (ADS)

    Hollowood, Timothy J.

    2016-07-01

    In our quantum mechanics courses, measurement is usually taught in passing, as an ad-hoc procedure involving the ugly collapse of the wave function. No wonder we search for more satisfying alternatives to the Copenhagen interpretation. But this overlooks the fact that the approach fits very well with modern measurement theory with its notions of the conditioned state and quantum trajectory. In addition, what we know of as the Copenhagen interpretation is a later 1950s development and some of the earlier pioneers like Bohr did not talk of wave function collapse. In fact, if one takes these earlier ideas and mixes them with later insights of decoherence, a much more satisfying version of Copenhagen quantum mechanics emerges, one for which the collapse of the wave function is seen to be a harmless book keeping device. Along the way, we explain why chaotic systems lead to wave functions that spread out quickly on macroscopic scales implying that Schrödinger cat states are the norm rather than curiosities generated in physicists' laboratories. We then describe how the conditioned state of a quantum system depends crucially on how the system is monitored illustrating this with the example of a decaying atom monitored with a time of arrival photon detector, leading to Bohr's quantum jumps. On the other hand, other kinds of detection lead to much smoother behaviour, providing yet another example of complementarity. Finally we explain how classical behaviour emerges, including classical mechanics but also thermodynamics.

  12. Quantum Computer Games: Quantum Minesweeper

    ERIC Educational Resources Information Center

    Gordon, Michal; Gordon, Goren

    2010-01-01

    The computer game of quantum minesweeper is introduced as a quantum extension of the well-known classical minesweeper. Its main objective is to teach the unique concepts of quantum mechanics in a fun way. Quantum minesweeper demonstrates the effects of superposition, entanglement and their non-local characteristics. While in the classical…

  13. Recent advances on integrated quantum communications

    NASA Astrophysics Data System (ADS)

    Orieux, Adeline; Diamanti, Eleni

    2016-08-01

    In recent years, the use of integrated technologies for applications in the field of quantum information processing and communications has made great progress. The resulting devices feature valuable characteristics such as scalability, reproducibility, low cost and interconnectivity, and have the potential to revolutionize our computation and communication practices in the future, much in the way that electronic integrated circuits have drastically transformed our information processing capacities since the last century. Among the multiple applications of integrated quantum technologies, this review will focus on typical components of quantum communication systems and on overall integrated system operation characteristics. We are interested in particular in the use of photonic integration platforms for developing devices necessary in quantum communications, including sources, detectors and both passive and active optical elements. We also illustrate the challenges associated with performing quantum communications on chip, by using the case study of quantum key distribution—the most advanced application of quantum information science. We conclude with promising perspectives in this field.

  14. Practical quantum key distribution protocol without monitoring signal disturbance.

    PubMed

    Sasaki, Toshihiko; Yamamoto, Yoshihisa; Koashi, Masato

    2014-05-22

    Quantum cryptography exploits the fundamental laws of quantum mechanics to provide a secure way to exchange private information. Such an exchange requires a common random bit sequence, called a key, to be shared secretly between the sender and the receiver. The basic idea behind quantum key distribution (QKD) has widely been understood as the property that any attempt to distinguish encoded quantum states causes a disturbance in the signal. As a result, implementation of a QKD protocol involves an estimation of the experimental parameters influenced by the eavesdropper's intervention, which is achieved by randomly sampling the signal. If the estimation of many parameters with high precision is required, the portion of the signal that is sacrificed increases, thus decreasing the efficiency of the protocol. Here we propose a QKD protocol based on an entirely different principle. The sender encodes a bit sequence onto non-orthogonal quantum states and the receiver randomly dictates how a single bit should be calculated from the sequence. The eavesdropper, who is unable to learn the whole of the sequence, cannot guess the bit value correctly. An achievable rate of secure key distribution is calculated by considering complementary choices between quantum measurements of two conjugate observables. We found that a practical implementation using a laser pulse train achieves a key rate comparable to a decoy-state QKD protocol, an often-used technique for lasers. It also has a better tolerance of bit errors and of finite-sized-key effects. We anticipate that this finding will give new insight into how the probabilistic nature of quantum mechanics can be related to secure communication, and will facilitate the simple and efficient use of conventional lasers for QKD.

  15. Practical quantum key distribution protocol without monitoring signal disturbance.

    PubMed

    Sasaki, Toshihiko; Yamamoto, Yoshihisa; Koashi, Masato

    2014-05-22

    Quantum cryptography exploits the fundamental laws of quantum mechanics to provide a secure way to exchange private information. Such an exchange requires a common random bit sequence, called a key, to be shared secretly between the sender and the receiver. The basic idea behind quantum key distribution (QKD) has widely been understood as the property that any attempt to distinguish encoded quantum states causes a disturbance in the signal. As a result, implementation of a QKD protocol involves an estimation of the experimental parameters influenced by the eavesdropper's intervention, which is achieved by randomly sampling the signal. If the estimation of many parameters with high precision is required, the portion of the signal that is sacrificed increases, thus decreasing the efficiency of the protocol. Here we propose a QKD protocol based on an entirely different principle. The sender encodes a bit sequence onto non-orthogonal quantum states and the receiver randomly dictates how a single bit should be calculated from the sequence. The eavesdropper, who is unable to learn the whole of the sequence, cannot guess the bit value correctly. An achievable rate of secure key distribution is calculated by considering complementary choices between quantum measurements of two conjugate observables. We found that a practical implementation using a laser pulse train achieves a key rate comparable to a decoy-state QKD protocol, an often-used technique for lasers. It also has a better tolerance of bit errors and of finite-sized-key effects. We anticipate that this finding will give new insight into how the probabilistic nature of quantum mechanics can be related to secure communication, and will facilitate the simple and efficient use of conventional lasers for QKD. PMID:24848060

  16. Tin Can Radiation Detector.

    ERIC Educational Resources Information Center

    Crull, John L.

    1986-01-01

    Provides instructions for making tin can radiation detectors from empty aluminum cans, aluminum foil, clear plastic, copper wire, silica gel, and fine, unwaxed dental floss put together with tape or glue. Also provides suggestions for activities using the detectors. (JN)

  17. Quantum memristors

    PubMed Central

    Pfeiffer, P.; Egusquiza, I. L.; Di Ventra, M.; Sanz, M.; Solano, E.

    2016-01-01

    Technology based on memristors, resistors with memory whose resistance depends on the history of the crossing charges, has lately enhanced the classical paradigm of computation with neuromorphic architectures. However, in contrast to the known quantized models of passive circuit elements, such as inductors, capacitors or resistors, the design and realization of a quantum memristor is still missing. Here, we introduce the concept of a quantum memristor as a quantum dissipative device, whose decoherence mechanism is controlled by a continuous-measurement feedback scheme, which accounts for the memory. Indeed, we provide numerical simulations showing that memory effects actually persist in the quantum regime. Our quantization method, specifically designed for superconducting circuits, may be extended to other quantum platforms, allowing for memristor-type constructions in different quantum technologies. The proposed quantum memristor is then a building block for neuromorphic quantum computation and quantum simulations of non-Markovian systems. PMID:27381511

  18. Quantum memristors.

    PubMed

    Pfeiffer, P; Egusquiza, I L; Di Ventra, M; Sanz, M; Solano, E

    2016-01-01

    Technology based on memristors, resistors with memory whose resistance depends on the history of the crossing charges, has lately enhanced the classical paradigm of computation with neuromorphic architectures. However, in contrast to the known quantized models of passive circuit elements, such as inductors, capacitors or resistors, the design and realization of a quantum memristor is still missing. Here, we introduce the concept of a quantum memristor as a quantum dissipative device, whose decoherence mechanism is controlled by a continuous-measurement feedback scheme, which accounts for the memory. Indeed, we provide numerical simulations showing that memory effects actually persist in the quantum regime. Our quantization method, specifically designed for superconducting circuits, may be extended to other quantum platforms, allowing for memristor-type constructions in different quantum technologies. The proposed quantum memristor is then a building block for neuromorphic quantum computation and quantum simulations of non-Markovian systems. PMID:27381511

  19. Quantum memristors.

    PubMed

    Pfeiffer, P; Egusquiza, I L; Di Ventra, M; Sanz, M; Solano, E

    2016-07-06

    Technology based on memristors, resistors with memory whose resistance depends on the history of the crossing charges, has lately enhanced the classical paradigm of computation with neuromorphic architectures. However, in contrast to the known quantized models of passive circuit elements, such as inductors, capacitors or resistors, the design and realization of a quantum memristor is still missing. Here, we introduce the concept of a quantum memristor as a quantum dissipative device, whose decoherence mechanism is controlled by a continuous-measurement feedback scheme, which accounts for the memory. Indeed, we provide numerical simulations showing that memory effects actually persist in the quantum regime. Our quantization method, specifically designed for superconducting circuits, may be extended to other quantum platforms, allowing for memristor-type constructions in different quantum technologies. The proposed quantum memristor is then a building block for neuromorphic quantum computation and quantum simulations of non-Markovian systems.

  20. Quantum memristors

    NASA Astrophysics Data System (ADS)

    Pfeiffer, P.; Egusquiza, I. L.; di Ventra, M.; Sanz, M.; Solano, E.

    2016-07-01

    Technology based on memristors, resistors with memory whose resistance depends on the history of the crossing charges, has lately enhanced the classical paradigm of computation with neuromorphic architectures. However, in contrast to the known quantized models of passive circuit elements, such as inductors, capacitors or resistors, the design and realization of a quantum memristor is still missing. Here, we introduce the concept of a quantum memristor as a quantum dissipative device, whose decoherence mechanism is controlled by a continuous-measurement feedback scheme, which accounts for the memory. Indeed, we provide numerical simulations showing that memory effects actually persist in the quantum regime. Our quantization method, specifically designed for superconducting circuits, may be extended to other quantum platforms, allowing for memristor-type constructions in different quantum technologies. The proposed quantum memristor is then a building block for neuromorphic quantum computation and quantum simulations of non-Markovian systems.

  1. Optical technologies for quantum information science

    NASA Astrophysics Data System (ADS)

    Kwiat, Paul G.; Altepeter, Joseph; Barreiro, Julio; Branning, David A.; Jeffrey, Evan R.; Peters, Nicholas; VanDevender, Aaron P.

    2004-02-01

    A number of optical technologies remain to be developed and optimized for various applications in quantum information processing, especially quantum communication. We will give an overview of our approach to some of these, including periodic heralded single-photon sources based on spontaneous parametric down-conversion, ultrabright sources of tunable entangled photons, near unit efficiency single- and multi-photon detectors based on an atomic vapor interaction, quantum state transducers based on high efficiency frequency up-conversion, and low-loss optical quantum memories.

  2. Segmented pyroelector detector

    DOEpatents

    Stotlar, S.C.; McLellan, E.J.

    1981-01-21

    A pyroelectric detector is described which has increased voltage output and improved responsivity over equivalent size detectors. The device comprises a plurality of edge-type pyroelectric detectors which have a length which is much greater than the width of the segments between the edge-type electrodes. External circuitry connects the pyroelectric detector segments in parallel to provide a single output which maintains 50 ohm impedance characteristics.

  3. Local Administration of NF-{kappa} B Decoy Oligonucleotides to Prevent Restenosis after Balloon Angioplasty: An Experimental Study in New Zealand White Rabbits

    SciTech Connect

    Kalinowski, Marc Viehofer, Kerstin; Hamann, Christine; Barry, James J.; Kleb, Beate; Klose, Klaus Jochen; Wagner, Hans-Joachim; Alfke, Heiko

    2005-04-15

    Purpose. To evaluate the efficacy of NF-{kappa} B oligonucleotides (ODN) administered by local administration with the channeled balloon catheter to prevent restenosis after balloon angioplasty in restenotic iliac arteries of New Zealand white rabbits. Materials and Methods. In vitro, 8000 rabbit vascular smooth muscle cells (rVSMC) where transfected with a liposomal carrier (TfX50) with 100 ng of decoy and scrambled ODN. Inhibition of proliferation was measured using a MTT assay after 24 hours in comparison to control. In vivo, 22 male New Zealand White rabbits were fed a 1% cholesterol diet and received denudation of both common iliac arteries with a 3 mm balloon catheter to induce an arterial stenosis. Four weeks after stenosis induction, local application of NF-{kappa} B in two different concentrations (1 {mu}g: n = 14; 10 {mu}g: n = 8) was performed randomly on one common iliac artery. Scrambled oligonucleotides without specific binding capacities were injected into the contralateral side. The channeled balloon catheter allows simultaneous balloon dilation (8 atm) of the stenosis and local application of a drug solution (2 atm). Four weeks after local drug delivery the animals were killed and the vessels were excised and computerized morphometric measurements were performed. Results. NF-{kappa} B decoy ODN but not scrambled ODN inhibited proliferation of rVSMC in vitro. Following local ODN application in the animals, no acute vascular complications were seen. NF-{kappa} B ODN resulted in a statistically non significant reduction of neointimal area compared to the control group. The neointimal area was 0.97 mm{sup 2} using 1 {mu}g NF-{kappa} B ODN compared to 0.98 mm{sup 2} in the control group. The higher dose resulted in a neointimal area of 0.97 mm{sup 2} compared to 1.07mm{sup 2} at the control side. Conclusions. Local drug delivery of NF-{kappa} B ODN using the 'channeled balloon' catheter could not reduce neointimal hyperplasia in stenostic rabbit iliac

  4. Extrinsic germanium Blocked Impurity Bank (BIB) detectors

    NASA Technical Reports Server (NTRS)

    Krabach, Timothy N.; Huffman, James E.; Watson, Dan M.

    1989-01-01

    Ge:Ga blocked-impurity-band (BIB) detectors with long wavelength thresholds greater than 190 microns and peak quantum efficiencies of 4 percent, at an operating temperature of 1.8 K, have been fabricated. These proof of concept devices consist of a high purity germanium blocking layer epitaxially grown on a Ga-doped Ge substrate. This demonstration of BIB behavior in germanium enables the development of far infrared detector arrays similar to the current silicon-based devices. Present efforts are focussed on improving the chemical vapor deposition process used to create the blocking layer and on the lithographic processing required to produce monolithic detector arrays in germanium. Approaches to test the impurity levels in both the blocking and active layers are considered.

  5. Gamma ray detector shield

    DOEpatents

    Ohlinger, R.D.; Humphrey, H.W.

    1985-08-26

    A gamma ray detector shield comprised of a rigid, lead, cylindrical-shaped vessel having upper and lower portions with an pneumatically driven, sliding top assembly. Disposed inside the lead shield is a gamma ray scintillation crystal detector. Access to the gamma detector is through the sliding top assembly.

  6. LGB neutron detector

    NASA Astrophysics Data System (ADS)

    Quist, Nicole

    2012-10-01

    The double pulse signature of the Gadolinium Lithium Borate Cerium doped plastic detector suggests its effectiveness for analyzing neutrons while providing gamma ray insensitivity. To better understand this detector, a californium gamma/neutron time of flight facility was constructed in our lab. Reported here are efforts to understand the properties and applications of the LGB detector with regards to neutron spectroscopy.

  7. Tevatron Detector Upgrades

    SciTech Connect

    Lipton, Ronald

    2005-03-22

    The D0 and CDF experiments are in the process of upgrading their detectors to cope with the high luminosities projected for the remainder of Tevatron Run II. We discuss the expected Tevatron environment through 2009, the detector challenges due to increasing luminosity in this period, and the solutions undertaken by the two experiments to mitigate detector problems and maximize physics results.

  8. Tevatron detector upgrades

    SciTech Connect

    Lipton, R.; /Fermilab

    2005-01-01

    The D0 and CDF experiments are in the process of upgrading their detectors to cope with the high luminosities projected for the remainder of Tevatron Run II. They discuss the expected Tevatron environment through 2009, the detector challenges due to increasing luminosity in this period, and the solutions undertaken by the two experiments to mitigate detector problems and maximize physics results.

  9. NUV Detector Dark Monitor

    NASA Astrophysics Data System (ADS)

    Zheng, Wei

    2010-09-01

    Perform routine monitoring of MAMA detector dark current. The main purpose isto look for evidence of a change in the dark rates, both to track on-orbit timedependence and to check for a detector problem developing. The spatial distribution of dark rates on the detector and the effect of SAA will also be studied.

  10. NUV Detector Dark Monitor

    NASA Astrophysics Data System (ADS)

    Ely, Justin

    2013-10-01

    Perform routine monitoring of MAMA detector dark current. The main purpose isto look for evidence of a change in the dark rates, both to track on-orbit timedependence and to check for a detector problem developing. The spatial distribution of dark rates on the detector and the effect of SAA will also be studied.

  11. NUV Detector Dark Monitor

    NASA Astrophysics Data System (ADS)

    Ely, Justin

    2012-10-01

    Perform routine monitoring of MAMA detector dark current. The main purpose isto look for evidence of a change in the dark rates, both to track on-orbit timedependence and to check for a detector problem developing. The spatial distribution of dark rates on the detector and the effect of SAA will also be studied.

  12. NUV Detector Dark Monitor

    NASA Astrophysics Data System (ADS)

    Cox, Colin

    2011-10-01

    Perform routine monitoring of MAMA detector dark current. The main purpose isto look for evidence of a change in the dark rates, both to track on-orbit timedependence and to check for a detector problem developing. The spatial distribution of dark rates on the detector and the effect of SAA will also be studied.

  13. Quantum Teardrops

    NASA Astrophysics Data System (ADS)

    Brzeziński, Tomasz; Fairfax, Simon A.

    2012-11-01

    Algebras of functions on quantum weighted projective spaces are introduced, and the structure of quantum weighted projective lines or quantum teardrops is described in detail. In particular the presentation of the coordinate algebra of the quantum teardrop in terms of generators and relations and classification of irreducible *-representations are derived. The algebras are then analysed from the point of view of Hopf-Galois theory or the theory of quantum principal bundles. Fredholm modules and associated traces are constructed. C*-algebras of continuous functions on quantum weighted projective lines are described and their K-groups computed.

  14. A Photon Counting Imaging Detector for NASA Exoplanet Mission

    NASA Astrophysics Data System (ADS)

    Figer, Donald

    The key objective of the proposed project is to advance the maturity of a 256x256 pixel single-photon optical imaging detector. The detector has zero read noise and is resilient against the harsh effects of radiation in space. We expect that the device will have state-of-the-art performance in other parameters, e.g., high quantum efficiency from UV to 1 #m, low dark current, etc.

  15. Robust quantum secure direct communication and authentication protocol against decoherence noise based on six-qubit DF state

    NASA Astrophysics Data System (ADS)

    Chang, Yan; Zhang, Shi-Bin; Yan, Li-Li; Han, Gui-Hua

    2015-05-01

    By using six-qubit decoherence-free (DF) states as quantum carriers and decoy states, a robust quantum secure direct communication and authentication (QSDCA) protocol against decoherence noise is proposed. Four six-qubit DF states are used in the process of secret transmission, however only the |0‧⟩ state is prepared. The other three six-qubit DF states can be obtained by permuting the outputs of the setup for |0‧⟩. By using the |0‧⟩ state as the decoy state, the detection rate and the qubit error rate reach 81.3%, and they will not change with the noise level. The stability and security are much higher than those of the ping-pong protocol both in an ideal scenario and a decoherence noise scenario. Even if the eavesdropper measures several qubits, exploiting the coherent relationship between these qubits, she can gain one bit of secret information with probability 0.042. Project supported by the National Natural Science Foundation of China (Grant No. 61402058), the Science and Technology Support Project of Sichuan Province of China (Grant No. 2013GZX0137), the Fund for Young Persons Project of Sichuan Province of China (Grant No. 12ZB017), and the Foundation of Cyberspace Security Key Laboratory of Sichuan Higher Education Institutions, China (Grant No. szjj2014-074).

  16. Graphene vertical hot-electron terahertz detectors

    SciTech Connect

    Ryzhii, V.; Satou, A.; Otsuji, T.; Ryzhii, M.; Mitin, V.; Shur, M. S.

    2014-09-21

    We propose and analyze the concept of the vertical hot-electron terahertz (THz) graphene-layer detectors (GLDs) based on the double-GL and multiple-GL structures with the barrier layers made of materials with a moderate conduction band off-set (such as tungsten disulfide and related materials). The operation of these detectors is enabled by the thermionic emissions from the GLs enhanced by the electrons heated by incoming THz radiation. Hence, these detectors are the hot-electron bolometric detectors. The electron heating is primarily associated with the intraband absorption (the Drude absorption). In the frame of the developed model, we calculate the responsivity and detectivity as functions of the photon energy, GL doping, and the applied voltage for the GLDs with different number of GLs. The detectors based on the cascade multiple-GL structures can exhibit a substantial photoelectric gain resulting in the elevated responsivity and detectivity. The advantages of the THz detectors under consideration are associated with their high sensitivity to the normal incident radiation and efficient operation at room temperature at the low end of the THz frequency range. Such GLDs with a metal grating, supporting the excitation of plasma oscillations in the GL-structures by the incident THz radiation, can exhibit a strong resonant response at the frequencies of several THz (in the range, where the operation of the conventional detectors based on A{sub 3}B{sub 5} materials, in particular, THz quantum-well detectors, is hindered due to a strong optical phonon radiation absorption in such materials). We also evaluate the characteristics of GLDs in the mid- and far-infrared ranges where the electron heating is due to the interband absorption in GLs.

  17. QUANTUM OPTICS. Universal linear optics.

    PubMed

    Carolan, Jacques; Harrold, Christopher; Sparrow, Chris; Martín-López, Enrique; Russell, Nicholas J; Silverstone, Joshua W; Shadbolt, Peter J; Matsuda, Nobuyuki; Oguma, Manabu; Itoh, Mikitaka; Marshall, Graham D; Thompson, Mark G; Matthews, Jonathan C F; Hashimoto, Toshikazu; O'Brien, Jeremy L; Laing, Anthony

    2015-08-14

    Linear optics underpins fundamental tests of quantum mechanics and quantum technologies. We demonstrate a single reprogrammable optical circuit that is sufficient to implement all possible linear optical protocols up to the size of that circuit. Our six-mode universal system consists of a cascade of 15 Mach-Zehnder interferometers with 30 thermo-optic phase shifters integrated into a single photonic chip that is electrically and optically interfaced for arbitrary setting of all phase shifters, input of up to six photons, and their measurement with a 12-single-photon detector system. We programmed this system to implement heralded quantum logic and entangling gates, boson sampling with verification tests, and six-dimensional complex Hadamards. We implemented 100 Haar random unitaries with an average fidelity of 0.999 ± 0.001. Our system can be rapidly reprogrammed to implement these and any other linear optical protocol, pointing the way to applications across fundamental science and quantum technologies. PMID:26160375

  18. Quantum Darwinism

    SciTech Connect

    Zurek, Wojciech H

    2008-01-01

    Quantum Darwinism - proliferation, in the environment, of multiple records of selected states of the system (its information-theoretic progeny) - explains how quantum fragility of individual state can lead to classical robustness of their multitude.

  19. Quantum memristors

    DOE PAGES

    Pfeiffer, P.; Egusquiza, I. L.; Di Ventra, M.; Sanz, M.; Solano, E.

    2016-07-06

    Technology based on memristors, resistors with memory whose resistance depends on the history of the crossing charges, has lately enhanced the classical paradigm of computation with neuromorphic architectures. However, in contrast to the known quantized models of passive circuit elements, such as inductors, capacitors or resistors, the design and realization of a quantum memristor is still missing. Here, we introduce the concept of a quantum memristor as a quantum dissipative device, whose decoherence mechanism is controlled by a continuous-measurement feedback scheme, which accounts for the memory. Indeed, we provide numerical simulations showing that memory effects actually persist in the quantummore » regime. Our quantization method, specifically designed for superconducting circuits, may be extended to other quantum platforms, allowing for memristor-type constructions in different quantum technologies. As a result, the proposed quantum memristor is then a building block for neuromorphic quantum computation and quantum simulations of non-Markovian systems.« less

  20. Stacked silicide/silicon mid- to long-wavelength infrared detector

    DOEpatents

    Maserjian, Joseph

    1990-03-13

    The use of stacked Schottky barriers (16) with epitaxially grown thin silicides (10) combined with selective doping (22) of the barriers provides high quantum efficiency infrared detectors (30) at longer wavelengths that is compatible with existing silicon VLSI technology.

  1. High-energy detector

    DOEpatents

    Bolotnikov, Aleksey E.; Camarda, Giuseppe; Cui, Yonggang; James, Ralph B.

    2011-11-22

    The preferred embodiments are directed to a high-energy detector that is electrically shielded using an anode, a cathode, and a conducting shield to substantially reduce or eliminate electrically unshielded area. The anode and the cathode are disposed at opposite ends of the detector and the conducting shield substantially surrounds at least a portion of the longitudinal surface of the detector. The conducting shield extends longitudinally to the anode end of the detector and substantially surrounds at least a portion of the detector. Signals read from one or more of the anode, cathode, and conducting shield can be used to determine the number of electrons that are liberated as a result of high-energy particles impinge on the detector. A correction technique can be implemented to correct for liberated electron that become trapped to improve the energy resolution of the high-energy detectors disclosed herein.

  2. Combinatorics and quantum nonlocality.

    PubMed

    Buhrman, Harry; Høyer, Peter; Massar, Serge; Röhrig, Hein

    2003-07-25

    We use techniques for lower bounds on communication to derive necessary conditions (in terms of detector efficiency or amount of superluminal communication) for being able to reproduce the quantum correlations occurring in Einstein-Podolsky-Rosen-type experiments with classical local hidden-variable theories. As an application, we consider n parties sharing a Greenberger-Horne-Zeilinger-type state and show that the amount of superluminal classical communication required to reproduce the correlations is at least n(log((2)n-3) bits and the maximum detector efficiency eta(*) for which the resulting correlations can still be reproduced by a local hidden-variable theory is upper bounded by eta(*)

  3. Discriminate protein decoys from native by using a scoring function based on ubiquitous Phi and Psi angles computed for all atom.

    PubMed

    Mishra, Avdesh; Iqbal, Sumaiya; Hoque, Md Tamjidul

    2016-06-01

    The success of solving the protein folding and structure prediction problems in molecular and structural biology relies on an accurate energy function. With the rapid advancement in the computational biology and bioinformatics fields, there is a growing need of solving unknown fold and structure faster and thus an accurate energy function is indispensable. To address this need, we develop a new potential function, namely 3DIGARS3.0, which is a linearly weighted combination of 3DIGARS, mined accessible surface area (ASA) and ubiquitously computed Phi (uPhi) and Psi (uPsi) energies - optimized by a Genetic Algorithm (GA). We use a dataset of 4332 protein-structures to generate uPhi and uPsi based score libraries to be used within the core 3DIGARS method. The optimized weight of each component is obtained by applying Genetic Algorithm based optimization on three challenging decoy sets. The improved 3DIGARS3.0 outperformed state-of-the-art methods significantly based on a set of independent test datasets.

  4. Adaptive spatial filtering for daytime satellite quantum key distribution

    NASA Astrophysics Data System (ADS)

    Gruneisen, Mark T.; Sickmiller, Brett A.; Flanagan, Michael B.; Black, James P.; Stoltenberg, Kurt E.; Duchane, Alexander W.

    2014-11-01

    The rate of secure key generation (SKG) in quantum key distribution (QKD) is adversely affected by optical noise and loss in the quantum channel. In a free-space atmospheric channel, the scattering of sunlight into the channel can lead to quantum bit error ratios (QBERs) sufficiently large to preclude SKG. Furthermore, atmospheric turbulence limits the degree to which spatial filtering can reduce sky noise without introducing signal losses. A system simulation quantifies the potential benefit of tracking and higher-order adaptive optics (AO) technologies to SKG rates in a daytime satellite engagement scenario. The simulations are performed assuming propagation from a low-Earth orbit (LEO) satellite to a terrestrial receiver that includes an AO system comprised of a Shack-Hartmann wave-front sensor (SHWFS) and a continuous-face-sheet deformable mirror (DM). The effects of atmospheric turbulence, tracking, and higher-order AO on the photon capture efficiency are simulated using statistical representations of turbulence and a time-domain waveoptics hardware emulator. Secure key generation rates are then calculated for the decoy state QKD protocol as a function of the receiver field of view (FOV) for various pointing angles. The results show that at FOVs smaller than previously considered, AO technologies can enhance SKG rates in daylight and even enable SKG where it would otherwise be prohibited as a consequence of either background optical noise or signal loss due to turbulence effects.

  5. Quantum displacement receiver for M-ary phase-shift-keyed coherent states

    SciTech Connect

    Izumi, Shuro; Takeoka, Masahiro; Fujiwara, Mikio; Sasaki, Masahide; Pozza, Nicola Dalla; Assalini, Antonio

    2014-12-04

    We propose quantum receivers for 3- and 4-ary phase-shift-keyed (PSK) coherent state signals to overcome the standard quantum limit (SQL). Our receiver, consisting of a displacement operation and on-off detectors with or without feedforward, provides an error probability performance beyond the SQL. We show feedforward operations can tolerate the requirement for the detector specifications.

  6. Quantum displacement receiver for M-ary phase-shift-keyed coherent states

    NASA Astrophysics Data System (ADS)

    Izumi, Shuro; Takeoka, Masahiro; Fujiwara, Mikio; Pozza, Nicola Dalla; Assalini, Antonio; Ema, Kazuhiro; Sasaki, Masahide

    2014-12-01

    We propose quantum receivers for 3- and 4-ary phase-shift-keyed (PSK) coherent state signals to overcome the standard quantum limit (SQL). Our receiver, consisting of a displacement operation and on-off detectors with or without feedforward, provides an error probability performance beyond the SQL. We show feedforward operations can tolerate the requirement for the detector specifications.

  7. The PHENIX Hadron Blind Detector

    SciTech Connect

    Durham, J. M.

    2009-03-10

    Dielectron measurements by the PHENIX Experiment at RHIC are limited by the combinatorial background from electrons and positrons which are not produced in the same pair. The Hadron Blind Detector will allow a substantial reduction of this background by correctly identifying dielectrons from photon conversions and pion Dalitz decays which dominate the signal in the low mass region of the spectrum. Triple GEM stacks, with a CsI photocathode deposited on the uppermost GEM, detect Cherenkov light produced by electrons in a CF{sub 4} radiator. The transparency of CF{sub 4}, high quantum efficiency of CsI in the UV, and absence of a window between the gas radiator and the GEMs allow a large photoelectron yield, while minimizing the hadron signal. Results from the HBD in RHIC's Run-7 and preparations for upcoming runs are discussed.

  8. Quantum criticality

    NASA Astrophysics Data System (ADS)

    Coleman, Piers; Schofield, Andrew J.

    2005-01-01

    As we mark the centenary of Albert Einstein's seminal contribution to both quantum mechanics and special relativity, we approach another anniversary - that of Einstein's foundation of the quantum theory of solids. But 100 years on, the same experimental measurement that puzzled Einstein and his contemporaries is forcing us to question our understanding of how quantum matter transforms at ultra-low temperatures.

  9. Practical quantum coin flipping

    NASA Astrophysics Data System (ADS)

    Pappa, Anna; Chailloux, André; Diamanti, Eleni; Kerenidis, Iordanis

    2011-11-01

    We show that in the unconditional security model, a single quantum strong coin flip with security guarantees that are strictly better than in any classical protocol is possible to implement with current technology. Our protocol takes into account all aspects of an experimental implementation, including losses, multiphoton pulses emitted by practical photon sources, channel noise, detector dark counts, and finite quantum efficiency. We calculate the abort probability when both players are honest, as well as the probability of one player forcing his desired outcome. For a channel length up to 21 km and commonly used parameter values, we can achieve honest abort and cheating probabilities that are better than in any classical protocol. Our protocol is, in principle, implementable using attenuated laser pulses, with no need for entangled photons or any other specific resources.

  10. Practical quantum coin flipping

    SciTech Connect

    Pappa, Anna; Diamanti, Eleni; Chailloux, Andre; Kerenidis, Iordanis

    2011-11-15

    We show that in the unconditional security model, a single quantum strong coin flip with security guarantees that are strictly better than in any classical protocol is possible to implement with current technology. Our protocol takes into account all aspects of an experimental implementation, including losses, multiphoton pulses emitted by practical photon sources, channel noise, detector dark counts, and finite quantum efficiency. We calculate the abort probability when both players are honest, as well as the probability of one player forcing his desired outcome. For a channel length up to 21 km and commonly used parameter values, we can achieve honest abort and cheating probabilities that are better than in any classical protocol. Our protocol is, in principle, implementable using attenuated laser pulses, with no need for entangled photons or any other specific resources.

  11. Photovoltaic Detector Based on Type II Heterostructure with Deep AlSb/InAsSb/AlSb Quantum Well in the Active Region for the Mid-Infrared Spectral Range

    NASA Astrophysics Data System (ADS)

    Konovalov, G. G.; Mikhailova, M. P.; Andreev, I. A.; Moiseev, K. D.; Ivanov, E. V.; Mikhailov, M. Yu; Yakovlev, Yu P.

    2013-08-01

    Photodetectors for the spectral range 2-4 μm, based on an asymmetric type-II heterostructure p-InAs/AlSb/InAsSb/AlSb/(p, n)-GaSb with a single deep quantum well (QW) or three deep QWs at the heterointerface, have been grown by metal-organic vapor phase epitaxy and analysed. The transport, luminescent, photoelectric, current-voltage, and capacitance-voltage characteristics of these structures have been examined. A high-intensity positive and negative luminescence was observed in the spectral range 3-4 μm at high temperatures (300-400 K). The photosensitivity spectra were in the range 1.2-3.6 μm (T = 77 K). Large values of quantum efficiency (η = 0.6-0.7), responsivity (Sλ = 0.9-1.4 A·W1), and detectivity D*λ 3.5·1011 to 1010 cm·Hz1/2·W-1) were obtained at T = 77-200 K. The small capacitance of the structures (C = 1.5 pF at V = -1 V and T = 300 K) enabled an estimate of the response time of the photodetector at τ = 75 ps, which corresponds to a bandwidth of about 6 GHz. Photodetectors of this kind are promising for heterodyne detection of the emission of quantum-cascade lasers and IR spectroscopy.

  12. New Generation of Superconducting Nanowire Single-Photon Detectors

    NASA Astrophysics Data System (ADS)

    Goltsman, G. N.

    2015-09-01

    We present an overview of recent results for new generation of infrared and optical superconducting nanowire single-photon detectors (SNSPDs) that has already demonstrated a performance that makes them devices-of-choice for many applications. SNSPDs provide high efficiency for detecting individual photons while keeping dark counts and timing jitter minimal. Besides superior detection performance over a broad optical bandwidth, SNSPDs are also compatible with an integrated optical platform as a crucial requirement for applications in emerging quantum photonic technologies. By embedding SNSPDs in nanophotonic circuits we realize waveguide integrated single photon detectors which unite all desirable detector properties in a single device.

  13. Optimal entanglement generation for efficient hybrid quantum repeaters

    SciTech Connect

    Azuma, Koji; Sota, Naoya; Yamamoto, Takashi; Koashi, Masato; Imoto, Nobuyuki; Namiki, Ryo; Oezdemir, Sahin Kaya

    2009-12-15

    We propose a realistic protocol to generate entanglement between quantum memories at neighboring nodes in hybrid quantum repeaters. Generated entanglement includes only one type of error, which enables efficient entanglement distillation. In contrast to the known protocols with such a property, our protocol with ideal detectors achieves the theoretical limit of the success probability and the fidelity to a Bell state, promising higher efficiencies in the repeaters. We also show that the advantage of our protocol remains even with realistic threshold detectors.

  14. Comparative Response of Microchannel Plate and Channel Electron Multiplier Detectors to Penetrating Radiation in Space

    SciTech Connect

    Funsten, Herbert O.; Harper, Ronnie W.; Dors, Eric E.; Janzen, Paul A.; Larsen, Brian A.; MacDonald, Elizabeth A.; Poston, David I.; Ritzau, Stephen M.; Skoug, Ruth M.; Zurbuchen, Thomas H.

    2015-10-02

    Channel electron multiplier (CEM) and microchannel plate (MCP) detectors are routinely used in space instrumentation for measurement of space plasmas. Here, our goal is to understand the relative sensitivities of these detectors to penetrating radiation in space, which can generate background counts and shorten detector lifetime. We use 662 keV γ-rays as a proxy for penetrating radiation such as γ-rays, cosmic rays, and high-energy electrons and protons that are ubiquitous in the space environment. We find that MCP detectors are ~20 times more sensitive to 662 keV γ-rays than CEM detectors. This is attributed to the larger total area of multiplication channels in an MCP detector that is sensitive to electronic excitation and ionization resulting from the interaction of penetrating radiation with the detector material. In contrast to the CEM detector, whose quantum efficiency εγ for 662 keVγ -rays is found to be 0.00175 and largely independent of detector bias, the quantum efficiency of the MCP detector is strongly dependent on the detector bias, with a power law index of 5.5. Lastly, background counts in MCP detectors from penetrating radiation can be reduced using MCP geometries with higher pitch and smaller channel diameter.

  15. Comparative Response of Microchannel Plate and Channel Electron Multiplier Detectors to Penetrating Radiation in Space

    DOE PAGES

    Funsten, Herbert O.; Harper, Ronnie W.; Dors, Eric E.; Janzen, Paul A.; Larsen, Brian A.; MacDonald, Elizabeth A.; Poston, David I.; Ritzau, Stephen M.; Skoug, Ruth M.; Zurbuchen, Thomas H.

    2015-10-02

    Channel electron multiplier (CEM) and microchannel plate (MCP) detectors are routinely used in space instrumentation for measurement of space plasmas. Here, our goal is to understand the relative sensitivities of these detectors to penetrating radiation in space, which can generate background counts and shorten detector lifetime. We use 662 keV γ-rays as a proxy for penetrating radiation such as γ-rays, cosmic rays, and high-energy electrons and protons that are ubiquitous in the space environment. We find that MCP detectors are ~20 times more sensitive to 662 keV γ-rays than CEM detectors. This is attributed to the larger total area ofmore » multiplication channels in an MCP detector that is sensitive to electronic excitation and ionization resulting from the interaction of penetrating radiation with the detector material. In contrast to the CEM detector, whose quantum efficiency εγ for 662 keVγ -rays is found to be 0.00175 and largely independent of detector bias, the quantum efficiency of the MCP detector is strongly dependent on the detector bias, with a power law index of 5.5. Lastly, background counts in MCP detectors from penetrating radiation can be reduced using MCP geometries with higher pitch and smaller channel diameter.« less

  16. Quantum frames

    NASA Astrophysics Data System (ADS)

    Brown, Matthew J.

    2014-02-01

    The framework of quantum frames can help unravel some of the interpretive difficulties i the foundation of quantum mechanics. In this paper, I begin by tracing the origins of this concept in Bohr's discussion of quantum theory and his theory of complementarity. Engaging with various interpreters and followers of Bohr, I argue that the correct account of quantum frames must be extended beyond literal space-time reference frames to frames defined by relations between a quantum system and the exosystem or external physical frame, of which measurement contexts are a particularly important example. This approach provides superior solutions to key EPR-type measurement and locality paradoxes.

  17. Quantum cheques

    NASA Astrophysics Data System (ADS)

    Moulick, Subhayan Roy; Panigrahi, Prasanta K.

    2016-06-01

    We propose the idea of a quantum cheque scheme, a cryptographic protocol in which any legitimate client of a trusted bank can issue a cheque, that cannot be counterfeited or altered in anyway, and can be verified by a bank or any of its branches. We formally define a quantum cheque and present the first unconditionally secure quantum cheque scheme and show it to be secure against any no-signalling adversary. The proposed quantum cheque scheme can been perceived as the quantum analog of Electronic Data Interchange, as an alternate for current e-Payment Gateways.

  18. Quantum Darwinism

    NASA Astrophysics Data System (ADS)

    Zurek, Wojciech Hubert

    2009-03-01

    Quantum Darwinism describes the proliferation, in the environment, of multiple records of selected states of a quantum system. It explains how the quantum fragility of a state of a single quantum system can lead to the classical robustness of states in their correlated multitude; shows how effective `wave-packet collapse' arises as a result of the proliferation throughout the environment of imprints of the state of the system; and provides a framework for the derivation of Born's rule, which relates the probabilities of detecting states to their amplitudes. Taken together, these three advances mark considerable progress towards settling the quantum measurement problem.

  19. Charged-coupled detector sky surveys.

    PubMed Central

    Schneider, D P

    1993-01-01

    Sky surveys have played a fundamental role in advancing our understanding of the cosmos. The current pictures of stellar evolution and structure and kinematics of our Galaxy were made possible by the extensive photographic and spectrographic programs performed in the early part of the 20th century. The Palomar Sky Survey, completed in the 1950s, is still the principal source for many investigations. In the past few decades surveys have been undertaken at radio, millimeter, infrared, and x-ray wavelengths; each has provided insights into new astronomical phenomena (e.g., quasars, pulsars, and the 3 degrees cosmic background radiation). The advent of high quantum efficiency, linear solid-state devices, in particular charged-coupled detectors, has brought about a revolution in optical astronomy. With the recent development of large-format charged-coupled detectors and the rapidly increasing capabilities of data acquisition and processing systems, it is now feasible to employ the full capabilities of electronic detectors in projects that cover an appreciable fraction of the sky. This talk reviews the first "large scale" charged-coupled detector survey. This program, designed to detect very distant quasars, reveals the powers and limitations of charged-coupled detector surveys. PMID:11607431

  20. Multispectral imaging with type II superlattice detectors

    NASA Astrophysics Data System (ADS)

    Ariyawansa, Gamini; Duran, Joshua M.; Grupen, Matt; Scheihing, John E.; Nelson, Thomas R.; Eismann, Michael T.

    2012-06-01

    Infrared (IR) focal plane arrays (FPAs) with multispectral detector elements promise significant advantages for airborne threat warning, surveillance, and targeting applications. At present, the use of type II superlattice (T2SL) structures based on the 6.1Å-family materials (InAs, GaSb, and AlSb) has become an area of interest for developing IR detectors and their FPAs. The ability to vary the bandgap in the IR range, suppression of Auger processes, prospective reduction of Shockley-Read-Hall centers by improved material growth capabilities, and the material stability are a few reasons for the predicted dominance of the T2SL technology over presently leading HgCdTe and quantum well technologies. The focus of the work reported here is on the development of T2SL based dual-band IR detectors and their applicability for multispectral imaging. A new NpBPN detector designed for the detection of IR in the 3-5 and 8-12 μm atmospheric windows is presented; comparing its advantages over other T2SL based approaches. One of the key challenges of the T2SL dual-band detectors is the spectral crosstalk associated with the LWIR band. The properties of the state-of-the-art T2SLs (i.e., absorption coefficient, minority carrier lifetime and mobility, etc.) and the present growth limitations that impact spectral crosstalk are discussed.

  1. Recent astronomical detector development at the University of Arizona

    NASA Astrophysics Data System (ADS)

    Lesser, Michael

    2012-07-01

    The University of Arizona Imaging Technology Laboratory (ITL) has been developing back illuminated detectors and detector technologies for several astronomical projects in recent years. These projects include the WIYN telescope One Degree Imager (ODI) mosaic of Orthogonal Transfer Array CCDs, the VIRUS detectors for the University of Texas' Hobby-Eberly Telescope Dark Energy Experiment (HETDEX), detector and packaging development for the Large Synoptic Survey Telescope (LSST), and 10kx10k and 4kx4k CCDs for several instruments. In this paper we discuss these projects with an emphasis on backside processing issues and detector characterization results which may be relevant to other groups. We will also focus packaging techniques and metrology for achieving very flat and stable focal planes. Results will include device flatness at cryogenic temperatures, process yield, photo-response non-uniformity and cosmetics, quantum efficiency, read noise, linearity, charge transfer efficiency, and photon transfer data.

  2. Advanced Si IR detectors using molecular beam epitaxy

    NASA Technical Reports Server (NTRS)

    Lin, T. L.; Jones, E. W.; George, T.; Ksendzov, A.; Huberman, M. L.

    1991-01-01

    SiGe/Si heterojunction internal photoemission (HIP) long wavelength infrared (LWIR) detectors have been fabricated by MBE. The SiGe/Si HIP detector offers a tailorable spectral response in the long wavelength infrared regime by varying the SiGe/Si heterojunction barrier. Degenerately doped p(+) SiGe layers were grown using elemental boron, as the dopant source allows a low growth temperature. Good crystalline quality was achieved for boron-doped SiGe due to the reduced growth temperature. The dark current density of the boron-doped HIP detectors was found to be thermionic emission limited. HIP detectors with a 0.066 eV were fabricated and characterized using activation energy analysis, corresponding to a 18 micron cutoff wavelength. Photoresponse of the detectors at wavelengths ranging from 2 to 12 microns has been characterized with corresponding quantum efficiencies of 5 - 0.1 percent.

  3. Neutrino Detectors: Challenges and Opportunities

    SciTech Connect

    Soler, F. J. P.

    2011-10-06

    This paper covers possible detector options suitable at future neutrino facilities, such as Neutrino Factories, Super Beams and Beta Beams. The Magnetised Iron Neutrino Detector (MIND), which is the baseline detector at a Neutrino Factory, will be described and a new analysis which improves the efficiency of this detector at low energies will be shown. Other detectors covered include the Totally Active Scintillating Detectors (TASD), particularly relevant for a low energy Neutrino Factory, emulsion detectors for tau detection, liquid argon detectors and megaton scale water Cherenkov detectors. Finally the requirements of near detectors for long-baseline neutrino experiments will be demonstrated.

  4. Quantum Cryptography

    NASA Astrophysics Data System (ADS)

    Fehr, Serge

    2010-05-01

    Quantum cryptography makes use of the quantum-mechanical behavior of nature for the design and analysis of cryptographic schemes. Optimally (but not always), quantum cryptography allows for the design of cryptographic schemes whose security is guaranteed solely by the laws of nature. This is in sharp contrast to standard cryptographic schemes, which can be broken in principle, i.e., when given sufficient computing power. From a theory point of view, quantum cryptography offers a beautiful interplay between the mathematics of adversarial behavior and quantum information theory. In this review article, we discuss the traditional application of quantum cryptography, quantum key distribution (QKD), from a modern perspective, and we discuss some recent developments in the context of quantum two-party cooperation (2PC). QKD allows two distant parties to communicate in a provably-secure way in the presence of an outside eavesdropper, whereas 2PC is concerned with protecting information against possibly malicious insiders. We show the basic idea of constructing quantum cryptographic schemes, but we also show some connections to quantum information theory as needed for the rigorous security analyses, and we discuss some of the relevant quantum-information-theoretic results.

  5. Two-dimensional Detector for High Resolution Soft X-ray Imaging

    SciTech Connect

    Ejima, Takeo; Ogasawara, Shodo; Hatano, Tadashi; Yanagihara, Mihiro; Yamamoto, Masaki

    2010-06-23

    A new two-dimensional (2D) detector for detecting soft X-ray (SX) images was developed. The detector has a scintillator plate to convert a SX image into a visible (VI) one, and a relay optics to magnify and detect the converted VI image. In advance of the fabrication of the detector, quantum efficiencies of scintillators were investigated. As a result, a Ce:LYSO single crystal on which Zr thin film was deposited was used as an image conversion plate. The spatial resolution of fabricated detector is 3.0 {mu}m, and the wavelength range which the detector has sensitivity is 30-6 nm region.

  6. Quantum Optics

    NASA Astrophysics Data System (ADS)

    Orvil Scully, Marlan; Zubairy, Muhammad Suhail

    1997-09-01

    Quantum optics has witnessed significant theoretical and experimental developments in recent years. This book provides an in-depth and wide-ranging introduction to the subject, emphasizing throughout the basic principles and their applications. The book begins by developing the basic tools of quantum optics, and goes on to show the application of these tools in a variety of quantum optical systems, including lasing without inversion, squeezed states, and atom optics. The final four chapters discuss quantum optical tests of the foundations of quantum mechanics, and particular aspects of measurement theory. Assuming only a background of standard quantum mechanics and electromagnetic theory, and containing many problems and references, this book will be invaluable to graduate students of quantum optics, as well as to researchers in this field.

  7. Quantum interference in heterogeneous superconducting-photonic circuits on a silicon chip

    PubMed Central

    Schuck, C.; Guo, X.; Fan, L.; Ma, X.; Poot, M.; Tang, H. X.

    2016-01-01

    Quantum information processing holds great promise for communicating and computing data efficiently. However, scaling current photonic implementation approaches to larger system size remains an outstanding challenge for realizing disruptive quantum technology. Two main ingredients of quantum information processors are quantum interference and single-photon detectors. Here we develop a hybrid superconducting-photonic circuit system to show how these elements can be combined in a scalable fashion on a silicon chip. We demonstrate the suitability of this approach for integrated quantum optics by interfering and detecting photon pairs directly on the chip with waveguide-coupled single-photon detectors. Using a directional coupler implemented with silicon nitride nanophotonic waveguides, we observe 97% interference visibility when measuring photon statistics with two monolithically integrated superconducting single-photon detectors. The photonic circuit and detector fabrication processes are compatible with standard semiconductor thin-film technology, making it possible to implement more complex and larger scale quantum photonic circuits on silicon chips. PMID:26792424

  8. Intelligent Detector Design

    SciTech Connect

    Graf, N.A.; /SLAC

    2012-06-11

    As the complexity and resolution of imaging detectors increases, the need for detailed simulation of the experimental setup also becomes more important. Designing the detectors requires efficient tools to simulate the detector response and reconstruct the events. We have developed efficient and flexible tools for detailed physics and detector response simulation as well as event reconstruction and analysis. The primary goal has been to develop a software toolkit and computing infrastructure to allow physicists from universities and labs to quickly and easily conduct physics analyses and contribute to detector research and development. The application harnesses the full power of the Geant4 toolkit without requiring the end user to have any experience with either Geant4 or C++, thereby allowing the user to concentrate on the physics of the detector system.

  9. Revealing of photon-number splitting attack on quantum key distribution system by photon-number resolving devices

    NASA Astrophysics Data System (ADS)

    Gaidash, A. A.; Egorov, V. I.; Gleim, A. V.

    2016-08-01

    Quantum cryptography allows distributing secure keys between two users so that any performed eavesdropping attempt would be immediately discovered. However, in practice an eavesdropper can obtain key information from multi-photon states when attenuated laser radiation is used as a source of quantum states. In order to prevent actions of an eavesdropper, it is generally suggested to implement special cryptographic protocols, like decoy states or SARG04. In this paper, we describe an alternative method based on monitoring photon number statistics after detection. We provide a useful rule of thumb to estimate approximate order of difference of expected distribution and distribution in case of attack. Formula for calculating a minimum value of total pulses or time-gaps to resolve attack is shown. Also formulas for actual fraction of raw key known to Eve were derived. This method can therefore be used with any system and even combining with mentioned special protocols.

  10. Germanium detector vacuum encapsulation

    NASA Technical Reports Server (NTRS)

    Madden, N. W.; Malone, D. F.; Pehl, R. H.; Cork, C. P.; Luke, P. N.; Landis, D. A.; Pollard, M. J.

    1991-01-01

    This paper describes an encapsulation technology that should significantly improve the viability of germanium gamma-ray detectors for a number of important applications. A specialized vacuum chamber has been constructed in which the detector and the encapsulating module are processed in high vacuum. Very high vacuum conductance is achieved within the valveless encapsulating module. The detector module is then sealed without breaking the chamber vacuum. The details of the vacuum chamber, valveless module, processing, and sealing method are presented.

  11. Detectors (4/5)

    ScienceCinema

    None

    2016-07-12

    This lecture will serve as an introduction to particle detectors and detection techniques. In the first lecture, a historic overview of particle detector development will be given. In the second lecture, some basic techniques and concepts for particle detection will be discussed. In the third lecture, the interaction of particles with matter, the basis of particle detection, will be presented. The fourth and fifth lectures will discuss different detector types used for particle tracking, energy measurement and particle identification.

  12. Detectors (5/5)

    ScienceCinema

    None

    2016-07-12

    This lecture will serve as an introduction to particle detectors and detection techniques. In the first lecture, a historic overview of particle detector development will be given. In the second lecture, some basic techniques and concepts for particle detection will be discussed. In the third lecture, the interaction of particles with matter, the basis of particle detection, will be presented. The fourth and fifth lectures will discuss different detector types used for particle tracking, energy measurement and particle identification.

  13. History of infrared detectors

    NASA Astrophysics Data System (ADS)

    Rogalski, A.

    2012-09-01

    This paper overviews the history of infrared detector materials starting with Herschel's experiment with thermometer on February 11th, 1800. Infrared detectors are in general used to detect, image, and measure patterns of the thermal heat radiation which all objects emit. At the beginning, their development was connected with thermal detectors, such as thermocouples and bolometers, which are still used today and which are generally sensitive to all infrared wavelengths and operate at room temperature. The second kind of detectors, called the photon detectors, was mainly developed during the 20th Century to improve sensitivity and response time. These detectors have been extensively developed since the 1940's. Lead sulphide (PbS) was the first practical IR detector with sensitivity to infrared wavelengths up to ˜3 μm. After World War II infrared detector technology development was and continues to be primarily driven by military applications. Discovery of variable band gap HgCdTe ternary alloy by Lawson and co-workers in 1959 opened a new area in IR detector technology and has provided an unprecedented degree of freedom in infrared detector design. Many of these advances were transferred to IR astronomy from Departments of Defence research. Later on civilian applications of infrared technology are frequently called "dual-use technology applications." One should point out the growing utilisation of IR technologies in the civilian sphere based on the use of new materials and technologies, as well as the noticeable price decrease in these high cost technologies. In the last four decades different types of detectors are combined with electronic readouts to make detector focal plane arrays (FPAs). Development in FPA technology has revolutionized infrared imaging. Progress in integrated circuit design and fabrication techniques has resulted in continued rapid growth in the size and performance of these solid state arrays.

  14. Photon Counting Detectors for the 1.0 - 2.0 Micron Wavelength Range

    NASA Technical Reports Server (NTRS)

    Krainak, Michael A.

    2004-01-01

    We describe results on the development of greater than 200 micron diameter, single-element photon-counting detectors for the 1-2 micron wavelength range. The technical goals include quantum efficiency in the range 10-70%; detector diameter greater than 200 microns; dark count rate below 100 kilo counts-per-second (cps), and maximum count rate above 10 Mcps.

  15. Adaptors for radiation detectors

    DOEpatents

    Livesay, Ronald Jason

    2015-07-28

    Described herein are adaptors and other devices for radiation detectors that can be used to make accurate spectral measurements of both small and large bulk sources of radioactivity, such as building structures, soils, vessels, large equipment, and liquid bodies. Some exemplary devices comprise an adaptor for a radiation detector, wherein the adaptor can be configured to collimate radiation passing through the adapter from an external radiation source to the radiation detector and the adaptor can be configured to enclose a radiation source within the adapter to allow the radiation detector to measure radiation emitted from the enclosed radiation source.

  16. Adaptors for radiation detectors

    DOEpatents

    Livesay, Ronald Jason

    2014-04-22

    Described herein are adaptors and other devices for radiation detectors that can be used to make accurate spectral measurements of both small and large bulk sources of radioactivity, such as building structures, soils, vessels, large equipment, and liquid bodies. Some exemplary devices comprise an adaptor for a radiation detector, wherein the adaptor can be configured to collimate radiation passing through the adapter from an external radiation source to the radiation detector and the adaptor can be configured to enclose a radiation source within the adapter to allow the radiation detector to measure radiation emitted from the enclosed radiation source.

  17. The CDFII Silicon Detector

    SciTech Connect

    Julia Thom

    2004-07-23

    The CDFII silicon detector consists of 8 layers of double-sided silicon micro-strip sensors totaling 722,432 readout channels, making it one of the largest silicon detectors in present use by an HEP experiment. After two years of data taking, we report on our experience operating the complex device. The performance of the CDFII silicon detector is presented and its impact on physics analyses is discussed. We have already observed measurable effects from radiation damage. These results and their impact on the expected lifetime of the detector are briefly reviewed.

  18. Quantum entanglement, quantum communication and the limits of quantum computing

    NASA Astrophysics Data System (ADS)

    Ambainis, Andris

    Quantum entanglement is a term describing the quantum correlations between different parts of a quantum system. Quantum information theory has developed sophisticated techniques to quantify and study quantum entanglement. In this thesis, we show how to apply those techniques to problems in quantum algorithms, complexity theory, communication and cryptography. The main results are: (1) quantum communication protocols that are exponentially more efficient that conventional (classical) communication protocols, (2) unconditionally secure quantum protocols for cryptographic problems, (3) a new "quantum adversary" method for proving lower bounds on quantum algorithms, (4) a study of "one clean qubit computation", a model related to the experimental implementation of quantum computers using NMR (nucleo-magnetic resonance) technology.

  19. Quantum volume

    NASA Astrophysics Data System (ADS)

    Ryabov, V. A.

    2015-08-01

    Quantum systems in a mechanical embedding, the breathing mode of a small particles, optomechanical system, etc. are far not the full list of examples in which the volume exhibits quantum behavior. Traditional consideration suggests strain in small systems as a result of a collective movement of particles, rather than the dynamics of the volume as an independent variable. The aim of this work is to show that some problem here might be essentially simplified by introducing periodic boundary conditions. At this case, the volume is considered as the independent dynamical variable driven by the internal pressure. For this purpose, the concept of quantum volume based on Schrödinger’s equation in 𝕋3 manifold is proposed. It is used to explore several 1D model systems: An ensemble of free particles under external pressure, quantum manometer and a quantum breathing mode. In particular, the influence of the pressure of free particle on quantum oscillator is determined. It is shown also that correction to the spectrum of the breathing mode due to internal degrees of freedom is determined by the off-diagonal matrix elements of the quantum stress. The new treatment not using the “force” theorem is proposed for the quantum stress tensor. In the general case of flexible quantum 3D dynamics, quantum deformations of different type might be introduced similarly to monopole mode.

  20. Infrared detectors: Advances, challenges and new technologies

    NASA Astrophysics Data System (ADS)

    Karim, Amir; Andersson, Jan Y.

    2013-12-01

    Human knowledge of infrared (IR) radiation is about 200 years old. However it was in the late 20th century that we developed a wide range of smart technologies for detection and started to take advantage for our benefit. Today IR detector technology is in its 3rd generation and comes with challenging demands. Based on the propagation of IR radiation through free space it is divided into different transmission windows. The most interesting for thermal imaging are the mid-wave IR (MWIR) and the long-wave IR (LW IR). Infrared detectors for thermal imaging have a number of applications in industry, security, search & rescue, surveillance, medicine, research, meteorology, climatology and astronomy. Currently high-performance IR imaging technology is mainly based on epitaxially grown structures of the small-bandgap bulk alloy mercury-cadmium-telluride (MCT), indium antimonide (InSb) and GaAs based quantum-well infrared photodetectors (QWIPs), depending on the application and wavelength range. However, they operate at low temperatures requiring costly and bulky cryogenic systems. In addition there is always a need for better performance, which generates possibilities for developing new technologies. Some emerging technologies are quantum dot infrared photodetectors (QDIPs), type-II strained layer super-lattice, and QDIPs with type-II band alignment. In this report a brief review of the current and new technologies for high performance IR detectors, will be presented.